<110>   Batelle Energy Alliance, LLC
   	Thompson, Vicki S.
	Apel, William A
    	Reed, David W
	Lee, Brady D.
	Thompson, David N	
	Roberto, Francisco F.
	Lacey, Jeffrey A.

<120>   THERMOPHILIC AND THERMOACIDOPHILIC METABOLISM GENES AND 
	ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED 
	ORGANISMS, METHODS

<130>   2939-866PC (BA-293)

<150>  	US 61/032,339
<151>  	2008-02-28

<160>   1581

<170>	INL Custom Script Ver 1.0 (Author: Cody Permann)

<210>   1
<211>   649
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1
Met Thr Pro Asn Asp Leu Asp Ala Leu Leu Arg Glu Thr Arg Thr Phe 
                5                   10                  15      

Ala Pro Ser Glu Glu Phe Arg Arg Gln Ala Asn Tyr Lys Asp Glu Ser 
            20                  25                  30          

Ile Tyr Glu Glu Ala Ala Arg Asp Pro Glu Gly Tyr Trp Ala Lys Gln 
        35                  40                  45              

Ala Glu His Ile Thr Trp Phe His Glu Phe Glu Ser Val Cys Arg Trp 
    50                  55                  60                  

Asp Pro Pro His Ala Gln Trp Phe Ile Gly Gly Lys Leu Asn Ala Ala 
65                  70                  75                  80  

Tyr Asn Cys Val Asp Arg His Thr Leu Thr His Arg Lys Asn Lys Ala 
                85                  90                  95      

Ala Ile Ile Trp Glu Gly Glu Pro Gly Asp Ser Arg Val Leu Thr Tyr 
            100                 105                 110         

Asp Met Leu Arg Arg Glu Val Asp Lys Ala Ala His Met Leu Thr Gln 
        115                 120                 125             

Leu Gly Val Lys Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Val 
    130                 135                 140                 

Pro Glu Leu Pro Ile Ala Met Leu Ala Cys Ala Lys Ile Gly Ala Met 
145                 150                 155                 160 

His Ser Val Val Phe Gly Gly Phe Ser Ala Gln Ala Leu Lys Asp Arg 
                165                 170                 175     

Ile Leu Asp Ala Gly Ser Lys Leu Leu Ile Thr Ala Asp Gly Gly Trp 
            180                 185                 190         

Arg Arg Gly Lys Val Ile Pro Leu Lys Gln Asn Ala Asp Glu Ala Val 
        195                 200                 205             

Val Gly Thr Pro Ile Glu Lys Val Val Val Val Gln Arg Ile Gly Glu 
    210                 215                 220                 

Ala Ala Gln Ala Ala Met Asp Pro Ala Arg Asp Val Trp Trp His Glu 
225                 230                 235                 240 

Ala Met Gln Ser Ala Pro Thr Lys Pro Phe Pro Ala Glu Pro Met Asp 
                245                 250                 255     

Ala Glu Asp Tyr Leu Phe Leu Leu Tyr Thr Ser Gly Thr Thr Gly Lys 
            260                 265                 270         

Pro Lys Gly Ile Val His Ser Thr Gly Gly Tyr Leu Val Gly Val Asn 
        275                 280                 285             

Thr Ser Met Arg Thr Val Phe Asp Leu Lys Asp Glu Asp Val Phe Phe 
    290                 295                 300                 

Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Thr Tyr Ile Val Tyr 
305                 310                 315                 320 

Gly Pro Leu Ser Ala Gly Ala Thr Val Val Met Tyr Glu Gly Ser Pro 
                325                 330                 335     

Asp Tyr Pro Asp Arg Asp Arg Tyr Trp Ala Ile Val Glu Lys Tyr Gly 
            340                 345                 350         

Ala Thr Ile Leu Tyr Thr Ala Pro Thr Ser Ile Arg Met Phe Met Lys 
        355                 360                 365             

Trp Gly Pro Gln Tyr Val Glu Lys His Asp Leu Ser Thr Leu Arg Leu 
    370                 375                 380                 

Leu Gly Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Met Trp Tyr 
385                 390                 395                 400 

His Lys Tyr Val Gly Gln Glu Arg Cys Pro Ile Val Asp Thr Trp Trp 
                405                 410                 415     

Gln Thr Glu Thr Gly Cys Ala Met Ile Ala Pro Leu Pro Gly Ile Ile 
            420                 425                 430         

Thr Thr Lys Pro Gly Ser Ala Thr Lys Pro Val Pro Gly Ile Ser Val 
        435                 440                 445             

Asp Ile Leu Asp Asp Asp Gly Asn Pro Val Pro Pro Gly His Gly Gly 
    450                 455                 460                 

Asn Leu Val Ile Thr Lys Pro Trp Pro Ser Met Leu Arg Thr Val Trp 
465                 470                 475                 480 

Gly Asp Asp Glu Arg Phe Arg Lys Thr Tyr Phe Glu Lys Phe Glu Gly 
                485                 490                 495     

Ile Tyr Leu Pro Gly Asp Gly Ala Tyr Arg Asp Gln Asp Gly Tyr Tyr 
            500                 505                 510         

Trp Ile Val Gly Arg Leu Asp Asp Val Ile Asn Val Ser Gly His Arg 
        515                 520                 525             

Ile Gly Thr Ala Glu Val Glu Ser Ala Leu Val Ala His Pro Ala Val 
    530                 535                 540                 

Ala Glu Ala Ala Val Ile Gly Arg Ala His Glu Val Lys Gly Gln Ala 
545                 550                 555                 560 

Ile Thr Ala Phe Val Ile Leu Lys Glu Gly His Thr Gly Ser Asp Asp 
                565                 570                 575     

Leu Val Ser Glu Leu Lys Gln Phe Val Val Glu Gln Ile Gly Ala Met 
            580                 585                 590         

Ala Arg Pro Glu Glu Ile Ile Phe Thr Ala Asp Leu Pro Lys Thr Arg 
        595                 600                 605             

Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Ile Ala Glu Gly Arg 
    610                 615                 620                 

Val Val Gly Asp Thr Thr Thr Leu Ala Asp Pro Ala Val Val Glu Gln 
625                 630                 635                 640 

Leu Lys Ser Gln Tyr Lys Asp Gln Glu 
                645                 

<210>   2
<211>   1950
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   2
atgaccccga atgatctcga cgcactactc cgtgaaaccc gcacctttgc cccgtccgaa       60

gaatttcgcc gccaagcgaa ttacaaggat gaaagcattt acgaggaagc tgctcgtgat      120

ccagagggtt actgggcgaa acaagccgaa catattactt ggttccatga atttgaaagc      180

gtttgcaggt gggatccgcc gcacgcgcaa tggttcatcg gcggcaagct gaacgccgcg      240

tataactgcg tggaccgtca caccctcact caccgcaaga ataaggcggc catcatctgg      300

gaaggcgagc caggcgacag ccgcgtcctc acgtacgaca tgttgcgccg cgaagtcgat      360

aaggccgcac acatgctcac ccagcttggg gtcaaaaagg gcgatcgcgt caccatctac      420

ctgcccatgg tgcccgagct ccccattgcg atgctcgcgt gcgccaaaat cggcgccatg      480

cattccgtcg tgttcggcgg attttccgcg caggcgctga aggatcgcat cctggacgcc      540

ggcagcaagc tgctcatcac ggcggacgga ggctggcgcc gcggcaaggt cattccgctc      600

aagcagaacg cggacgaagc cgtcgtggga acgcccatcg agaaggttgt ggtcgtccag      660

cggatcggcg aagcggctca ggcagccatg gatccggcgc gagacgtctg gtggcacgaa      720

gccatgcaga gcgcgccgac caagcccttc ccggctgagc ccatggacgc ggaagactac      780

ctgttcctgc tctacacgtc tggcaccacg ggcaagccga agggcattgt ccacagcacg      840

ggcggatacc tggtgggcgt caacacgtcc atgcggaccg tgttcgatct gaaggacgaa      900

gacgtgttct tctgcacggc ggacatcggc tggatcaccg gccacacgta catcgtgtac      960

ggcccgctgt cggccggcgc gacggtcgtc atgtacgagg gatcgcccga ttatcccgat     1020

cgcgaccggt actgggccat cgtcgagaag tacggcgcga ccatcctgta caccgcgccg     1080

acatccatcc gcatgttcat gaaatggggt ccccagtacg tcgaaaagca cgatctcagc     1140

acgctccggc tgctcggatc tgtcggcgag cccattaacc cggaggcgtg gatgtggtac     1200

cacaagtacg tcggccagga gcggtgcccc atcgtggaca cctggtggca gacggaaacc     1260

ggttgcgcga tgatcgcgcc tctgccaggc attatcacca ccaagccggg ttctgccacc     1320

aagcccgtgc ccggcatctc cgtcgatatc cttgacgacg acggcaatcc ggtgccgccg     1380

gggcatggcg gaaatctcgt catcaccaag ccctggccgt ccatgctgcg cacggtgtgg     1440

ggcgatgacg agcgcttccg caagacgtac ttcgagaagt tcgagggcat ctacctgcct     1500

ggggacggcg cgtaccgaga tcaggatggc tactactgga ttgtcggacg gctggacgac     1560

gtgatcaacg tgtcgggcca ccgcattggc actgcggaag tggagagcgc gctggtggct     1620

catcccgctg tcgccgaggc ggccgtgatc gggcgcgccc acgaagtcaa ggggcaggcc     1680

atcaccgcgt ttgtcatcct caaagagggc cacaccggtt cggacgatct cgtctcggaa     1740

ctgaagcaat tcgtcgtcga gcaaatcggc gccatggcgc ggccggagga gatcatcttc     1800

acggccgatc tgcccaagac gcgcagcggc aagattatgc gccgcctgtt gcgcgacatc     1860

gcggaaggcc gtgtggtcgg cgacaccacc accctggccg atccggccgt cgtggagcaa     1920

ctgaaatcgc agtacaagga tcaggaatga                                      1950


<210>   3
<211>   652
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   3
Met Asp Ser Lys Gln Phe Ala Ala Leu Leu Asn Glu Asp Arg Arg Phe 
                5                   10                  15      

Pro Pro Pro Ala Glu Phe Ala Ala Arg Ala Asn Val Ala Asp Glu Ser 
            20                  25                  30          

Leu Tyr Glu Gln Ala Ala Arg Asp Arg Glu Gly Phe Trp Ala Ala Gln 
        35                  40                  45              

Ala Glu Arg Leu His Trp Phe Arg Arg Trp Asp Lys Val Leu Glu Trp 
    50                  55                  60                  

Asn Pro Pro Phe Ala Gln Trp Phe Leu Gly Gly Lys Leu Asn Val Ala 
65                  70                  75                  80  

Tyr Asn Cys Leu Asp Arg His Leu Gln Thr His Thr Arg Thr Lys Ala 
                85                  90                  95      

Ala Ile Ile Trp Glu Gly Glu Pro Gly Asp Glu Arg Val Leu Thr Tyr 
            100                 105                 110         

Leu Asp Leu His Arg Glu Val Cys Arg Phe Ala Asn Val Leu Arg Gln 
        115                 120                 125             

Met Gly Val Gly Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Ile 
    130                 135                 140                 

Pro Glu Ala Ala Val Ala Met Leu Ala Cys Thr Arg Ile Gly Ala Ile 
145                 150                 155                 160 

His Ser Val Val Phe Gly Gly Phe Ser Ala Glu Ser Leu Arg Asp Arg 
                165                 170                 175     

Ile Asn Asp Ser Arg Ser Lys Val Val Val Thr Ala Asp Gly Gly Trp 
            180                 185                 190         

Arg Arg Gly Asn Ile Ile Arg Met Lys Gln Ile Val Asn Glu Ala Val 
        195                 200                 205             

Val Asp Cys Ala Ser Val Glu Lys Val Ile Val Val Lys Arg Ile Gly 
    210                 215                 220                 

His Glu Ser Leu Val Glu His Gly Trp His Pro Gly Arg Asp His Trp 
225                 230                 235                 240 

Tyr His Thr Leu Met Arg Asn Ala Pro Val Thr Cys Pro Val Glu Glu 
                245                 250                 255     

Met Asp Ala Glu Asp Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr 
            260                 265                 270         

Gly Lys Pro Lys Gly Val Leu His Thr Thr Gly Gly Tyr Leu Thr Gln 
        275                 280                 285             

Val Ala Ala Thr Thr Lys Tyr Val Phe Asp Leu Lys Asp Glu Asp Val 
    290                 295                 300                 

Tyr Trp Cys Ser Ala Asp Ile Gly Trp Ile Thr Gly His Ser Tyr Val 
305                 310                 315                 320 

Ile Tyr Gly Pro Leu Ala Asn Gly Ala Thr Thr Leu Met Tyr Glu Gly 
                325                 330                 335     

Ala Pro Asp Tyr Pro Asp Arg Gly Arg Ile Trp Glu Ile Ile Gln Lys 
            340                 345                 350         

Tyr Arg Val Asn Ile Phe Tyr Thr Ala Pro Thr Leu Ile Arg Ser Phe 
        355                 360                 365             

Met Arg Trp Gly Glu Gly Trp Pro Ser Lys Tyr Asp Leu Ser Ser Leu 
    370                 375                 380                 

Arg Leu Leu Gly Thr Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Met 
385                 390                 395                 400 

Trp Tyr His Lys His Ile Gly Gly Glu Arg Cys Pro Ile Val Asp Thr 
                405                 410                 415     

Trp Trp Gln Thr Glu Thr Gly Ala Ile Met Ala Thr Pro Leu Pro Gly 
            420                 425                 430         

Val Val His Thr Lys Pro Gly Ser Thr Thr Arg Pro Phe Pro Gly Ile 
        435                 440                 445             

Glu Met Ala Val Val Asn Glu Glu Gly Gln Glu Val Pro Pro Gly Ala 
    450                 455                 460                 

Gly Gly Tyr Leu Val Val Lys Ser Pro Trp Pro Ser Met Leu Arg Thr 
465                 470                 475                 480 

Val Trp Gly Asp Pro Asp Arg Tyr Val Ser Thr Tyr Phe Gly Arg Phe 
                485                 490                 495     

Gly His Gln Val Tyr Phe Thr Gly Asp Gly Ala Lys Arg Asp Glu Asp 
            500                 505                 510         

Gly Tyr Tyr Trp Ile Ile Gly Arg Val Asp Asp Val Ile Asn Val Ser 
        515                 520                 525             

Gly His Arg Ile Gly Thr Met Glu Val Glu Ser Ala Leu Val Asp His 
    530                 535                 540                 

Pro Leu Val Ala Glu Ala Ala Val Ile Gly Arg Ser His Ala Val Lys 
545                 550                 555                 560 

Gly Gln Ala Ile Thr Ala Phe Val Thr Leu Lys Glu Gly Arg Arg Gly 
                565                 570                 575     

Thr Pro Asp Leu Val Asp Glu Leu Lys Gln His Val Val Thr Lys Ile 
            580                 585                 590         

Gly Ala Leu Ala Arg Pro Glu Glu Ile Tyr Phe Ala Ala Asp Leu Pro 
        595                 600                 605             

Lys Thr Arg Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Ile Ala 
    610                 615                 620                 

Glu Gly Arg Ala Leu Gly Asp Thr Thr Thr Leu Ala Asp Pro Asn Val 
625                 630                 635                 640 

Val Ala Gln Leu Arg Gln Gln Tyr Glu Ser Gln Glu 
                645                 650         

<210>   4
<211>   644
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   4
Asp Asn Phe Glu Ala Leu Leu Gln Glu Ser Arg Ile Phe Glu Pro Pro 
                5                   10                  15      

Ala Glu Phe Lys Glu Lys Ala Lys Val Ala Asp Leu Ser Leu Tyr Glu 
            20                  25                  30          

Trp Ala Glu Arg Asp Phe Leu Gly Phe Trp Ala Asp Ala Ala Lys Asp 
        35                  40                  45              

Ile Glu Trp Phe Leu Pro Phe Glu Lys Val Leu Asp Asp Ser Asp Ala 
    50                  55                  60                  

Pro Phe Tyr Arg Trp Tyr Thr Gly Gly Lys Leu Asn Val Ser Tyr Asn 
65                  70                  75                  80  

Cys Val Asp Arg His Thr Lys Ser Phe Arg Arg Asn Lys Ala Ala Leu 
                85                  90                  95      

Ile Phe Glu Gly Glu Pro Gly Asp Ser Lys Ile Leu Thr Tyr Gln Glu 
            100                 105                 110         

Leu Tyr Arg Glu Val Asn Lys Phe Ala Asn Val Leu Lys Lys Leu Gly 
        115                 120                 125             

Val Gln Lys Gly Asp Arg Val Thr Ile Tyr Met Pro Met Ile Pro Glu 
    130                 135                 140                 

Ala Val Ile Ala Met Leu Ala Cys Thr Arg Ile Gly Ala Pro His Ser 
145                 150                 155                 160 

Val Val Phe Gly Gly Phe Ser Ser Gln Ala Leu Lys Asp Arg Ile Asp 
                165                 170                 175     

Asp Ala Lys Ala Lys Leu Leu Ile Thr Ala Asp Gly Gly Tyr Arg Arg 
            180                 185                 190         

Gly Ser Ile Val Glu Leu Lys Lys Asn Ala Asp Ala Ala Leu Glu Gly 
        195                 200                 205             

Glu Thr Thr Ile Glu Lys Val Val Val Val Lys Arg Thr Gly Gln Glu 
    210                 215                 220                 

Val Pro Met Thr Glu Gly Arg Asp Tyr Trp Tyr His Glu Leu Met Ala 
225                 230                 235                 240 

Asp Ala Ala Leu Tyr Cys Glu Pro Glu Gln Cys Asp Ala Glu Asp Met 
                245                 250                 255     

Leu Phe Ile Leu Tyr Ser Ser Gly Thr Thr Gly Lys Pro Lys Gly Ile 
            260                 265                 270         

Gln His Thr Thr Gly Gly Tyr Leu Val Gly Val His Thr Thr Phe Lys 
        275                 280                 285             

Tyr Ile Phe Asp Tyr Arg Glu Glu Asp Ile Tyr Trp Cys Thr Ala Asp 
    290                 295                 300                 

Ile Gly Trp Ile Thr Gly His Ser Tyr Ile Val Tyr Gly Pro Leu Ser 
305                 310                 315                 320 

Asn Gly Ala Thr Val Val Leu Tyr Glu Gly Ala Pro Asp Trp Pro Gln 
                325                 330                 335     

Lys Asp Arg Phe Trp Glu Ile Ile Glu Lys Tyr Arg Val Asn Ile Leu 
            340                 345                 350         

Tyr Thr Ala Pro Thr Ala Ile Arg Thr Phe Met Arg Trp Gly Glu Lys 
        355                 360                 365             

Trp Pro Lys Gly Arg Asp Leu Ser Ser Leu Arg Leu Leu Gly Thr Val 
    370                 375                 380                 

Gly Glu Pro Ile Asn Pro Glu Ala Trp Ile Trp Tyr His Glu His Ile 
385                 390                 395                 400 

Gly Gly Gly Arg Cys Pro Ile Val Asp Thr Trp Trp Gln Thr Glu Thr 
                405                 410                 415     

Gly Met Ile Met Ile Thr Pro Leu Pro Gly Val Ile Pro Thr Lys Pro 
            420                 425                 430         

Gly Ser Ala Thr Lys Pro Phe Pro Gly Val Glu Ala Asp Val Val Asn 
        435                 440                 445             

Asp Lys Gly Glu Pro Val Pro Pro Gly Gln Gly Gly Tyr Leu Val Leu 
    450                 455                 460                 

Lys Lys Pro Trp Pro Ala Met Leu Arg Thr Leu Tyr Gly Asp Pro Glu 
465                 470                 475                 480 

Arg Tyr Lys Asn Thr Tyr Trp Ser Lys Phe Pro Gly Trp Tyr Phe Thr 
                485                 490                 495     

Gly Asp Gly Ala Lys Lys Asp Glu Asp Gly Tyr Phe Trp Ile Leu Gly 
            500                 505                 510         

Arg Val Asp Asp Val Ile Asn Val Ser Gly His Arg Ile Gly Thr Met 
        515                 520                 525             

Glu Val Glu Ser Ala Leu Val Glu His Pro Leu Val Ala Glu Ala Ala 
    530                 535                 540                 

Val Ile Gly Lys Ser His Glu Val Lys Gly Gln Ala Ile Ala Ala Phe 
545                 550                 555                 560 

Val Thr Leu Lys Glu Gly Val Glu Gly Thr Pro Glu Leu Val Gln Glu 
                565                 570                 575     

Leu Lys Gln Phe Val Ala Gln Lys Ile Gly Ala Leu Ala Arg Pro Asp 
            580                 585                 590         

Asp Ile Phe Phe Thr Ala Glu Leu Pro Lys Thr Arg Ser Gly Lys Ile 
        595                 600                 605             

Met Arg Arg Leu Leu Arg Asp Ile Ala Glu Gly Arg Ala Leu Gly Asp 
    610                 615                 620                 

Thr Thr Thr Leu Thr Asp Pro Ala Val Ile Asn Lys Ile Lys Glu Gln 
625                 630                 635                 640 

Tyr Lys Asp Glu 
                

<210>   5
<211>   643
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   5
Met Glu Glu Lys Asn Leu Glu Ala Leu Leu Glu Glu Asp Arg Gln Phe 
                5                   10                  15      

Ile Pro Ser Glu Glu Phe His Lys Asn Ala Leu Ile Gln Ser Ala Asp 
            20                  25                  30          

Ile Tyr Glu Gln Gly Gln Ser Leu Gly Phe Trp Glu Glu Gln Ala Lys 
        35                  40                  45              

Gln Leu Ser Trp Leu Ser Pro Trp Glu Lys Thr Leu Glu Trp Asn Pro 
    50                  55                  60                  

Pro Phe Ala Gln Trp Phe Val Gly Gly Lys Leu Asn Ala Ser Ala Asn 
65                  70                  75                  80  

Cys Leu Asp Arg His Leu Gln Asp Trp His Arg Asn Lys Ala Ala Ile 
                85                  90                  95      

Ile Phe Glu Gly Glu Asn Gly Asp Ser Gln Val Leu Thr Tyr Gln Asp 
            100                 105                 110         

Leu His Arg Glu Val Ser Lys Phe Ala Asn Val Leu Lys Ala Asn Gly 
        115                 120                 125             

Val Asn Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Ile Pro Glu 
    130                 135                 140                 

Ala Val Ile Ser Met Leu Ala Cys Ala Arg Ile Gly Ala Pro His Ser 
145                 150                 155                 160 

Val Val Phe Gly Gly Phe Ser Ser Glu Ala Leu Arg Asp Arg Val Ile 
                165                 170                 175     

Asp Ala Gln Ala Lys Ala Val Ile Thr Ser Asp Gly Ser Phe Arg Arg 
            180                 185                 190         

Gly Asn Thr Ile Pro Leu Lys Asp Asn Thr Asp Ile Ala Leu Asp Gly 
        195                 200                 205             

Val Asp Cys Val Glu His Val Phe Val Ile Gln Arg Thr Lys Gln Thr 
    210                 215                 220                 

Val Gln Met Lys Glu Glu Arg Asp Leu Trp Tyr His Glu Glu Met Ala 
225                 230                 235                 240 

Lys Ala Ser Pro Val Cys Pro Ala Glu Pro Met Asp Ala Glu Asp Met 
                245                 250                 255     

Leu Phe Ile Leu Tyr Thr Ser Gly Thr Thr Gly Lys Pro Lys Gly Val 
            260                 265                 270         

Val His Thr Thr Gly Gly Tyr Met Val Gly Val Ser Thr Thr His Arg 
        275                 280                 285             

Trp Val Phe Asp Leu Lys Glu Glu Asp Val Tyr Trp Cys Thr Ala Asp 
    290                 295                 300                 

Val Gly Trp Ile Thr Gly His Ser Tyr Ile Val Tyr Gly Pro Leu Ala 
305                 310                 315                 320 

Asn Gly Ala Thr Val Leu Met Tyr Glu Gly Ser Pro Asp Tyr Pro Asn 
                325                 330                 335     

Arg Asp Arg Phe Trp Glu Ile Val Glu Lys Tyr Lys Val Thr Ile Leu 
            340                 345                 350         

Tyr Thr Ala Pro Thr Ala Ile Arg Thr Phe Met Lys Trp Gly Pro Gln 
        355                 360                 365             

Tyr Pro Gln Ser Arg Asp Leu Ser Ser Leu Arg Leu Leu Gly Ser Val 
    370                 375                 380                 

Gly Glu Pro Ile Asn Pro Glu Ala Trp Met Trp Tyr Tyr Lys Tyr Ile 
385                 390                 395                 400 

Gly Gly Glu Arg Cys Pro Ile Val Asp Thr Trp Trp Gln Thr Glu Thr 
                405                 410                 415     

Gly Met Ile Met Met Thr Pro Leu Pro Gly Ile Thr Ser Leu Lys Pro 
            420                 425                 430         

Gly Ser Cys Thr Val Pro Phe Pro Gly Val Arg Ile Glu Val Val Asp 
        435                 440                 445             

Ser Ala Gly His Pro Val Pro Lys Gly Gly Gly Gly Tyr Leu Ala Ile 
    450                 455                 460                 

Lys Glu Pro Trp Pro Ala Met Leu Arg Asn Ile Tyr Gly Asp Pro Ala 
465                 470                 475                 480 

Arg Phe Glu Arg Thr Tyr Phe Gly Asn Trp Pro Gly Val Tyr Phe Pro 
                485                 490                 495     

Gly Asp Gly Ala Lys Trp Asp Lys Asp Gly Tyr Phe Trp Ile Leu Gly 
            500                 505                 510         

Arg Val Asp Asp Val Ile Asn Val Ser Gly His Arg Ile Gly Thr Met 
        515                 520                 525             

Glu Val Glu Ser Ala Leu Val Asp His Pro Ser Val Ala Glu Ala Ala 
    530                 535                 540                 

Val Ile Gly Lys Asn His Glu Val Lys Gly Gln Ala Leu Ala Cys Phe 
545                 550                 555                 560 

Val Thr Leu Lys Glu Gly Ile Glu Ile Thr Pro Asp Leu Glu Asp Glu 
                565                 570                 575     

Leu Lys Lys His Val Ala Lys Lys Ile Gly Ala Leu Ala Arg Pro Asp 
            580                 585                 590         

Asp Ile Phe Phe Thr Ala Glu Leu Pro Lys Thr Arg Ser Gly Lys Ile 
        595                 600                 605             

Met Arg Arg Leu Leu Arg Asp Ile Ala Glu Gly Arg Ala Ile Gly Asp 
    610                 615                 620                 

Thr Thr Thr Leu Ala Asp Ala Ser Val Val Asn Thr Leu Lys Ala Asn 
625                 630                 635                 640 

Tyr Gln Glu 
            

<210>   6
<211>   631
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   6
Arg Thr Tyr Asp Pro Pro Glu Glu Phe Ala Ser Arg Ala Asn Val Arg 
                5                   10                  15      

Asp Pro Gly Val Tyr Glu Glu Ala Ala Arg Asp Tyr Glu Gly Phe Trp 
            20                  25                  30          

Ala Glu Arg Ala Arg Lys Leu His Trp Phe Arg Glu Trp Asp Glu Val 
        35                  40                  45              

Leu Arg Trp Asp Pro Pro Glu Ala Gln Trp Phe Val Gly Gly Lys Ile 
    50                  55                  60                  

Asn Ala Ser Tyr Asn Cys Leu Asp Tyr Gln Val Gln Gln Gly Arg Gly 
65                  70                  75                  80  

Asp Lys Arg Ala Ile Ile Trp Glu Gly Asp Glu Pro Gly Glu Asn Arg 
                85                  90                  95      

Thr Leu Thr Tyr Ser Glu Leu Lys Ala Glu Val Glu Lys Phe Ala Asn 
            100                 105                 110         

Val Leu Lys Gly Leu Gly Val Arg Lys Gly Asp Ala Val Ser Ile Tyr 
        115                 120                 125             

Leu Pro Met Ile Pro Glu Leu Pro Ile Ala Met Leu Ala Cys Ala Arg 
    130                 135                 140                 

Ile Gly Ala Pro His Ser Val Val Phe Gly Ala Phe Ser Ala Gln Ser 
145                 150                 155                 160 

Leu Arg Asp Arg Ile Asn Asp Cys Glu Ala Lys Val Leu Val Thr Ala 
                165                 170                 175     

Asp Ser Gly Pro Arg Gly Gly Lys Arg Thr Pro Leu Lys Ala Asn Ala 
            180                 185                 190         

Asp Glu Ala Leu Glu Asp Thr Pro Ser Ile Glu Lys Val Val Val Val 
        195                 200                 205             

Arg Arg Thr Gly Asp Glu Val Asn Met Val Glu Gly Arg Asp Leu Trp 
    210                 215                 220                 

Trp His Glu Leu Met Arg Glu Ala Glu Pro Glu Cys Pro Ala Glu Glu 
225                 230                 235                 240 

Met Asp Ser Glu Asp Ile Leu Tyr Ile Leu Tyr Ser Ser Gly Ser Thr 
                245                 250                 255     

Gly Lys Pro Lys Gly Ile Val His Thr Thr Gly Gly Tyr Leu Thr His 
            260                 265                 270         

Val Asn Thr Thr Thr Asp Trp Val Phe Asp Leu Lys Glu Asp Asp Val 
        275                 280                 285             

Tyr Trp Cys Thr Ala Asp Ile Gly Trp Val Thr Gly His Ser Tyr Ile 
    290                 295                 300                 

Val Tyr Gly Pro Leu Ser Asn Gly Ala Thr Ala Leu Met Phe Glu Gly 
305                 310                 315                 320 

Thr Pro Ser Tyr Pro Ala Asn Asp Arg Trp Trp Asp Ile Ile Glu Arg 
                325                 330                 335     

His Gly Val Thr Ile Leu Tyr Thr Ala Pro Thr Ala Ile Arg Ala Phe 
            340                 345                 350         

Met Lys Gln Gly Pro Gly Pro Ile Glu Lys His Asp Leu Ser Ser Leu 
        355                 360                 365             

Arg Leu Leu Gly Ser Val Gly Glu Pro Ile Asn Pro Arg Ala Trp Glu 
    370                 375                 380                 

Trp Tyr His Glu His Val Gly Gly Gly Arg Cys Pro Val Val Asp Thr 
385                 390                 395                 400 

Trp Trp Gln Thr Glu Thr Gly Gly Ile Met Ile Ser Pro Leu Pro Gly 
                405                 410                 415     

Ile Thr Arg Thr Lys Pro Gly Ser Ala Thr Phe Pro Leu Pro Gly Ile 
            420                 425                 430         

Phe Ala Gly Ile Tyr Asp Glu Glu Gly Asn Glu Ile Glu Gly Pro Gly 
        435                 440                 445             

Val Gly Asn Leu Val Ile Lys Arg Pro Trp Pro Gly Met Leu Arg Thr 
    450                 455                 460                 

Leu Tyr Lys Asp Pro Glu Arg Phe Arg Glu Thr Tyr Trp Gln Lys Tyr 
465                 470                 475                 480 

Gly Asp Val Tyr Phe Ser Gly Asp Gly Ala Arg Arg Asp Glu Asp Gly 
                485                 490                 495     

Tyr Phe Trp Val Thr Gly Arg Val Asp Asp Val Ile Asn Val Ser Gly 
            500                 505                 510         

His Arg Ile Ser Thr Ala Glu Val Glu Ser Ala Leu Val Ala His Pro 
        515                 520                 525             

Ala Val Ala Glu Ala Ala Val Ile Gly Arg Tyr Asp Glu Asp Thr Gly 
    530                 535                 540                 

Gln Ala Ile Val Ala Tyr Val Ile Leu Glu Gly Gly Arg Glu Gly Asn 
545                 550                 555                 560 

Asp Glu Leu Ala Gln Glu Leu Arg Gln Gln Val Arg Lys Val Ile Gly 
                565                 570                 575     

Ala His Ala Arg Pro Gln Glu Ile Ile Phe Thr Pro Asp Leu Pro Lys 
            580                 585                 590         

Thr Arg Ser Gly Lys Ile Met Arg Arg Ile Leu Arg Ser Leu Ser Glu 
        595                 600                 605             

Gly Arg Asp Asp Leu Gly Asp Thr Thr Thr Leu Ala Asp Pro Gly Val 
    610                 615                 620                 

Val Glu Ser Leu Lys Glu Gln 
625                 630     

<210>   7
<211>   642
<212>   PRT
<213>   Thermus thermophilus HB8

<400>   7
Leu Glu Ser Val Leu Lys Glu Glu Arg Val Phe Tyr Pro Ser Glu Glu 
                5                   10                  15      

Phe Arg Lys Gln Ala His Ile Lys Ser Glu Glu Glu Tyr Gln Arg Leu 
            20                  25                  30          

Tyr Glu Glu Ser Val Arg Asp Pro Glu Gly Phe Trp Gly Arg Val Ala 
        35                  40                  45              

Ser Glu Leu His Trp Phe Glu Pro Trp Arg Lys Val Leu Glu Gly Asp 
    50                  55                  60                  

Leu Pro His Pro Lys Trp Phe Val Gly Gly Lys Thr Asn Leu Ser Tyr 
65                  70                  75                  80  

Asn Ala Leu Asp Arg His Val Lys Thr Trp Arg Arg Asn Lys Ala Ala 
                85                  90                  95      

Ile Val Trp Glu Gly Glu Pro Gly Glu Glu Arg Val Leu Thr Tyr His 
            100                 105                 110         

Asp Leu Trp Arg Glu Val Gln Arg Phe Ala Asn Val Leu Lys Arg Leu 
        115                 120                 125             

Gly Val Lys Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Ile Pro 
    130                 135                 140                 

Glu Ala Ala Ile Ala Met Leu Ala Cys Thr Arg Ile Gly Ala Val His 
145                 150                 155                 160 

Ser Val Val Phe Gly Gly Phe Ser Ala Gly Ala Leu Ala Asp Arg Ile 
                165                 170                 175     

Lys Asp Ala Glu Ala Lys Val Leu Ile Thr Ala Asp Gly Gly Phe Arg 
            180                 185                 190         

Arg Gly Gly Ile Val Pro Leu Lys Gln Asn Ala Asp Glu Ala Leu Lys 
        195                 200                 205             

Asp Ala Thr Ser Val Glu His Val Val Val Val Arg Arg Thr Gly Glu 
    210                 215                 220                 

Glu Val Pro Trp Thr Pro Gly Arg Asp His Trp Trp His Glu Leu Met 
225                 230                 235                 240 

Glu Ala Ala Pro Asp Arg Cys Asp Pro Glu Pro Met Glu Ala Glu Glu 
                245                 250                 255     

Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys Gly 
            260                 265                 270         

Val Leu His Thr Thr Gly Gly Tyr Met Thr Tyr Val Tyr Tyr Thr Thr 
        275                 280                 285             

Lys Leu Val Phe Asp Leu Lys Asp Glu Asp Val Tyr Trp Cys Thr Ala 
    290                 295                 300                 

Asp Val Gly Trp Ile Thr Gly His Ser Tyr Val Val Tyr Gly Pro Leu 
305                 310                 315                 320 

Leu Asn Gly Ala Thr Thr Val Met Tyr Glu Gly Ala Pro Asn Trp Pro 
                325                 330                 335     

Glu Pro Asp Arg Phe Trp Arg Ile Val Asp Lys Tyr Gly Val Thr Val 
            340                 345                 350         

Phe Tyr Thr Ala Pro Thr Ala Ile Arg Ser Phe Met Lys Trp Gly Glu 
        355                 360                 365             

Gly Trp Pro Gly Lys His Arg Leu Asp Ser Leu Arg Leu Leu Gly Thr 
    370                 375                 380                 

Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Leu Trp Tyr Tyr His Val 
385                 390                 395                 400 

Ile Gly Lys Gly Arg Cys Pro Ile Val Asp Thr Trp Trp Gln Thr Glu 
                405                 410                 415     

Thr Gly Gly Ile Met Ile Thr Thr Leu Pro Gly Ala His Ala Met Lys 
            420                 425                 430         

Pro Gly His Ala Gly Lys Pro Phe Phe Gly Val Val Pro Glu Ile Leu 
        435                 440                 445             

Asp Gly Glu His Arg Pro Val Glu Asn Pro Asp Glu Gly Gly His Leu 
    450                 455                 460                 

Cys Ile Thr Arg Pro Trp Pro Ser Met Leu Arg Thr Val Trp Gly Asp 
465                 470                 475                 480 

Pro Glu Arg Phe Leu Gln Gln Tyr Phe Ser Gln His Pro Gly Val Tyr 
                485                 490                 495     

Phe Ser Gly Asp Gly Ala Lys Arg Asp Lys Asp Gly Tyr Tyr Met Ile 
            500                 505                 510         

Leu Gly Arg Val Asp Asp Val Leu Asn Val Ala Gly His Arg Leu Gly 
        515                 520                 525             

Thr Met Glu Ile Glu Ser Ala Leu Val Ala His Pro Ala Val Ala Glu 
    530                 535                 540                 

Ala Ala Val Val Gly Arg Pro Asp Pro Val Lys Gly Glu Ala Ile Val 
545                 550                 555                 560 

Ala Phe Val Thr Leu Lys Glu Gly His Thr Pro Ser Asp Ala Leu Lys 
                565                 570                 575     

Glu Glu Leu Arg Ala His Val Ala Lys Val Ile Gly Pro Ile Ala Arg 
            580                 585                 590         

Pro Asp Glu Ile Arg Phe Thr Asp Ala Leu Pro Lys Thr Arg Ser Gly 
        595                 600                 605             

Lys Ile Met Arg Arg Leu Leu Arg Gln Ile Ala Ala Gly Glu Lys Glu 
    610                 615                 620                 

Ile Lys Gly Asp Thr Ser Thr Leu Glu Asp Arg Ser Val Val Glu Arg 
625                 630                 635                 640 

Leu Lys 
        

<210>   8
<211>   649
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   8
Met Thr Pro Asn Asp Leu Asp Ala Leu Leu Arg Glu Thr Arg Thr Phe 
                5                   10                  15      

Ala Pro Ser Glu Glu Phe Arg Arg Gln Ala Asn Tyr Lys Asp Glu Ser 
            20                  25                  30          

Ile Tyr Glu Glu Ala Ala Arg Asp Pro Glu Gly Tyr Trp Ala Lys Gln 
        35                  40                  45              

Ala Glu His Ile Thr Trp Phe His Glu Phe Glu Ser Val Cys Arg Trp 
    50                  55                  60                  

Asp Pro Pro His Ala Gln Trp Phe Ile Gly Gly Lys Leu Asn Ala Ala 
65                  70                  75                  80  

Tyr Asn Cys Val Asp Arg His Thr Leu Thr His Arg Lys Asn Lys Ala 
                85                  90                  95      

Ala Ile Ile Trp Glu Gly Glu Pro Gly Asp Ser Arg Val Leu Thr Tyr 
            100                 105                 110         

Asp Met Leu Arg Arg Glu Val Asp Lys Ala Ala His Met Leu Thr Gln 
        115                 120                 125             

Leu Gly Val Lys Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Val 
    130                 135                 140                 

Pro Glu Leu Pro Ile Ala Met Leu Ala Cys Ala Lys Ile Gly Ala Met 
145                 150                 155                 160 

His Ser Val Val Phe Gly Gly Phe Ser Ala Gln Ala Leu Lys Asp Arg 
                165                 170                 175     

Ile Leu Asp Ala Gly Ser Lys Leu Leu Ile Thr Ala Asp Gly Gly Trp 
            180                 185                 190         

Arg Arg Gly Lys Val Ile Pro Leu Lys Gln Asn Ala Asp Glu Ala Val 
        195                 200                 205             

Val Gly Thr Pro Ile Glu Lys Val Val Val Val Gln Arg Ile Gly Glu 
    210                 215                 220                 

Ala Ala Gln Ala Ala Met Asp Pro Ala Arg Asp Val Trp Trp His Glu 
225                 230                 235                 240 

Ala Met Gln Ser Ala Pro Thr Lys Pro Phe Pro Ala Glu Pro Met Asp 
                245                 250                 255     

Ala Glu Asp Tyr Leu Phe Leu Leu Tyr Thr Ser Gly Thr Thr Gly Lys 
            260                 265                 270         

Pro Lys Gly Ile Val His Ser Thr Gly Gly Tyr Leu Val Gly Val Asn 
        275                 280                 285             

Thr Ser Met Arg Thr Val Phe Asp Leu Lys Asp Glu Asp Val Phe Phe 
    290                 295                 300                 

Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Thr Tyr Ile Val Tyr 
305                 310                 315                 320 

Gly Pro Leu Ser Ala Gly Ala Thr Val Val Met Tyr Glu Gly Ser Pro 
                325                 330                 335     

Asp Tyr Pro Asp Arg Asp Arg Tyr Trp Ala Ile Val Glu Lys Tyr Gly 
            340                 345                 350         

Ala Thr Ile Leu Tyr Thr Ala Pro Thr Ser Ile Arg Met Phe Met Lys 
        355                 360                 365             

Trp Gly Pro Gln Tyr Val Glu Lys His Asp Leu Ser Thr Leu Arg Leu 
    370                 375                 380                 

Leu Gly Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Met Trp Tyr 
385                 390                 395                 400 

His Lys Tyr Val Gly Gln Glu Arg Cys Pro Ile Val Asp Thr Trp Trp 
                405                 410                 415     

Gln Thr Glu Thr Gly Cys Ala Met Ile Ala Pro Leu Pro Gly Ile Ile 
            420                 425                 430         

Thr Thr Lys Pro Gly Ser Ala Thr Lys Pro Val Pro Gly Ile Ser Val 
        435                 440                 445             

Asp Ile Ile Asp Asp Asp Gly Asn Pro Val Pro Pro Gly His Gly Gly 
    450                 455                 460                 

Asn Leu Val Ile Thr Lys Pro Trp Pro Ser Met Leu Arg Thr Val Trp 
465                 470                 475                 480 

Gly Asp Asp Glu Arg Phe Arg Lys Thr Tyr Phe Glu Lys Phe Glu Gly 
                485                 490                 495     

Ile Tyr Leu Pro Gly Asp Gly Ala Tyr Arg Asp Gln Asp Gly Tyr Tyr 
            500                 505                 510         

Trp Ile Val Gly Arg Leu Asp Asp Val Ile Asn Val Ser Gly His Arg 
        515                 520                 525             

Ile Gly Thr Ala Glu Val Glu Ser Ala Leu Val Ala His Pro Ala Val 
    530                 535                 540                 

Ala Glu Ala Ala Val Ile Gly Arg Ala His Glu Val Lys Gly Gln Ala 
545                 550                 555                 560 

Ile Thr Ala Phe Val Ile Leu Lys Glu Gly His Thr Gly Ser Asp Asp 
                565                 570                 575     

Leu Val Ser Glu Leu Lys Gln Phe Val Val Glu Gln Ile Gly Ala Met 
            580                 585                 590         

Ala Arg Pro Glu Glu Ile Ile Phe Thr Ala Asp Leu Pro Lys Thr Arg 
        595                 600                 605             

Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Ile Ala Glu Gly Arg 
    610                 615                 620                 

Val Val Gly Asp Thr Thr Thr Leu Ala Asp Pro Ala Val Val Glu Gln 
625                 630                 635                 640 

Leu Lys Ser Gln Tyr Lys Asp Gln Glu 
                645                 

<210>   9
<211>   649
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   9
Met Thr Pro Asn Asp Leu Asp Ala Leu Leu Arg Glu Thr Arg Thr Phe 
                5                   10                  15      

Ala Pro Ser Glu Glu Phe Arg Arg Gln Ala Asn Tyr Lys Asp Glu Ser 
            20                  25                  30          

Ile Tyr Glu Glu Ala Ala Arg Asp Pro Glu Gly Tyr Trp Ala Lys Gln 
        35                  40                  45              

Ala Glu His Ile Thr Trp Phe His Glu Phe Glu Ser Val Cys Arg Trp 
    50                  55                  60                  

Asp Pro Pro His Ala Gln Trp Phe Ile Gly Gly Lys Leu Asn Ala Ala 
65                  70                  75                  80  

Tyr Asn Cys Val Asp Arg His Thr Leu Thr His Arg Lys Asn Lys Ala 
                85                  90                  95      

Ala Ile Ile Trp Glu Gly Glu Pro Gly Asp Ser Arg Val Leu Thr Tyr 
            100                 105                 110         

Asp Met Leu Arg Arg Glu Val Asp Lys Ala Ala His Met Leu Thr Gln 
        115                 120                 125             

Leu Gly Val Lys Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Val 
    130                 135                 140                 

Pro Glu Leu Pro Ile Ala Met Leu Ala Cys Ala Lys Ile Gly Ala Met 
145                 150                 155                 160 

His Ser Val Val Phe Gly Gly Phe Ser Ala Gln Ala Leu Lys Asp Arg 
                165                 170                 175     

Ile Leu Asp Ala Gly Ser Lys Leu Leu Ile Thr Ala Asp Gly Gly Trp 
            180                 185                 190         

Arg Arg Gly Lys Val Ile Pro Leu Lys Gln Asn Ala Asp Glu Ala Val 
        195                 200                 205             

Val Gly Thr Pro Ile Glu Lys Val Val Val Val Gln Arg Ile Gly Glu 
    210                 215                 220                 

Ala Ala Gln Ala Ala Met Asp Pro Ala Arg Asp Val Trp Trp His Glu 
225                 230                 235                 240 

Ala Met Gln Ser Ala Pro Thr Lys Pro Phe Pro Ala Glu Pro Met Asp 
                245                 250                 255     

Ala Glu Asp Tyr Leu Phe Leu Leu Tyr Thr Ser Gly Thr Thr Gly Lys 
            260                 265                 270         

Pro Lys Gly Ile Val His Ser Thr Gly Gly Tyr Leu Val Gly Val Asn 
        275                 280                 285             

Thr Ser Met Arg Thr Val Phe Asp Leu Lys Asp Glu Asp Val Phe Phe 
    290                 295                 300                 

Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Thr Tyr Ile Val Tyr 
305                 310                 315                 320 

Gly Pro Leu Ser Ala Gly Ala Thr Val Val Met Tyr Glu Gly Ser Pro 
                325                 330                 335     

Asp Tyr Pro Asp Arg Asp Arg Tyr Trp Ala Ile Val Glu Lys Tyr Gly 
            340                 345                 350         

Ala Thr Ile Leu Tyr Thr Ala Pro Thr Ser Ile Arg Met Phe Met Lys 
        355                 360                 365             

Trp Gly Pro Gln Tyr Val Glu Lys His Asp Leu Ser Thr Leu Arg Leu 
    370                 375                 380                 

Leu Gly Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Met Trp Tyr 
385                 390                 395                 400 

His Lys Tyr Val Gly Gln Glu Arg Cys Pro Ile Val Asp Thr Trp Trp 
                405                 410                 415     

Gln Thr Glu Thr Gly Cys Ala Met Ile Ala Pro Leu Pro Gly Ile Ile 
            420                 425                 430         

Thr Thr Lys Pro Gly Ser Ala Thr Lys Pro Val Pro Gly Ile Ser Val 
        435                 440                 445             

Asp Ile Leu Asp Asp Asp Gly Asn Pro Val Pro Pro Gly His Gly Gly 
    450                 455                 460                 

Asn Leu Val Ile Thr Lys Pro Trp Pro Ser Met Leu Arg Thr Val Trp 
465                 470                 475                 480 

Gly Asp Asp Glu Arg Phe Arg Lys Thr Tyr Phe Glu Lys Phe Glu Gly 
                485                 490                 495     

Ile Tyr Leu Pro Gly Asp Gly Ala Tyr Arg Asp Gln Asp Gly Tyr Tyr 
            500                 505                 510         

Trp Ile Ile Gly Arg Leu Asp Asp Val Ile Asn Val Ser Gly His Arg 
        515                 520                 525             

Ile Gly Thr Ala Glu Val Glu Ser Ala Leu Val Ala His Pro Ala Val 
    530                 535                 540                 

Ala Glu Ala Ala Val Ile Gly Arg Ala His Glu Val Lys Gly Gln Ala 
545                 550                 555                 560 

Ile Thr Ala Phe Val Ile Leu Lys Glu Gly His Thr Gly Ser Asp Asp 
                565                 570                 575     

Leu Val Ser Glu Leu Lys Gln Phe Val Val Glu Gln Ile Gly Ala Met 
            580                 585                 590         

Ala Arg Pro Glu Glu Ile Ile Phe Thr Ala Asp Leu Pro Lys Thr Arg 
        595                 600                 605             

Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Ile Ala Glu Gly Arg 
    610                 615                 620                 

Val Val Gly Asp Thr Thr Thr Leu Ala Asp Pro Ala Val Val Glu Gln 
625                 630                 635                 640 

Leu Lys Ser Gln Tyr Lys Asp Gln Glu 
                645                 

<210>   10
<211>   649
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   10
Met Thr Pro Asn Asp Leu Asp Ala Leu Leu Arg Glu Thr Arg Thr Phe 
                5                   10                  15      

Ala Pro Ser Glu Glu Phe Arg Arg Gln Ala Asn Tyr Lys Asp Glu Ser 
            20                  25                  30          

Ile Tyr Glu Glu Ala Ala Arg Asp Pro Glu Gly Tyr Trp Ala Lys Gln 
        35                  40                  45              

Ala Glu His Ile Thr Trp Phe His Glu Phe Glu Ser Val Cys Arg Trp 
    50                  55                  60                  

Asp Pro Pro His Ala Gln Trp Phe Ile Gly Gly Lys Leu Asn Ala Ala 
65                  70                  75                  80  

Tyr Asn Cys Val Asp Arg His Thr Leu Thr His Arg Lys Asn Lys Ala 
                85                  90                  95      

Ala Ile Ile Trp Glu Gly Glu Pro Gly Asp Ser Arg Val Leu Thr Tyr 
            100                 105                 110         

Asp Met Leu Arg Arg Glu Val Asp Lys Ala Ala His Met Leu Thr Gln 
        115                 120                 125             

Leu Gly Val Lys Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Val 
    130                 135                 140                 

Pro Glu Leu Pro Ile Ala Met Leu Ala Cys Ala Lys Ile Gly Ala Met 
145                 150                 155                 160 

His Ser Val Val Phe Gly Gly Phe Ser Ala Gln Ala Leu Lys Asp Arg 
                165                 170                 175     

Ile Leu Asp Ala Gly Ser Lys Leu Leu Ile Thr Ala Asp Gly Gly Trp 
            180                 185                 190         

Arg Arg Gly Lys Val Ile Pro Leu Lys Gln Asn Ala Asp Glu Ala Val 
        195                 200                 205             

Val Gly Thr Pro Ile Glu Lys Val Val Val Val Gln Arg Ile Gly Glu 
    210                 215                 220                 

Ala Ala Gln Ala Ala Met Asp Pro Ala Arg Asp Val Trp Trp His Glu 
225                 230                 235                 240 

Ala Met Gln Ser Ala Pro Thr Lys Pro Phe Pro Ala Glu Pro Met Asp 
                245                 250                 255     

Ala Glu Asp Tyr Leu Phe Leu Leu Tyr Thr Ser Gly Thr Thr Gly Lys 
            260                 265                 270         

Pro Lys Gly Ile Val His Ser Thr Gly Gly Tyr Leu Val Gly Val Asn 
        275                 280                 285             

Thr Ser Met Arg Thr Val Phe Asp Leu Lys Asp Glu Asp Val Phe Phe 
    290                 295                 300                 

Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Thr Tyr Ile Val Tyr 
305                 310                 315                 320 

Gly Pro Leu Ser Ala Gly Ala Thr Val Val Met Tyr Glu Gly Ser Pro 
                325                 330                 335     

Asp Tyr Pro Asp Arg Asp Arg Tyr Trp Ala Ile Val Glu Lys Tyr Gly 
            340                 345                 350         

Ala Thr Ile Leu Tyr Thr Ala Pro Thr Ser Ile Arg Met Phe Met Lys 
        355                 360                 365             

Trp Gly Pro Gln Tyr Val Glu Lys His Glu Leu Ser Thr Leu Arg Leu 
    370                 375                 380                 

Leu Gly Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Met Trp Tyr 
385                 390                 395                 400 

His Lys Tyr Val Gly Gln Glu Arg Cys Pro Ile Val Asp Thr Trp Trp 
                405                 410                 415     

Gln Thr Glu Thr Gly Cys Ala Met Ile Ala Pro Leu Pro Gly Ile Ile 
            420                 425                 430         

Thr Thr Lys Pro Gly Ser Ala Thr Lys Pro Val Pro Gly Ile Ser Val 
        435                 440                 445             

Asp Ile Leu Asp Asp Asp Gly Asn Pro Val Pro Pro Gly His Gly Gly 
    450                 455                 460                 

Asn Leu Val Ile Thr Lys Pro Trp Pro Ser Met Leu Arg Thr Val Trp 
465                 470                 475                 480 

Gly Asp Asp Glu Arg Phe Arg Lys Thr Tyr Phe Glu Lys Phe Glu Gly 
                485                 490                 495     

Ile Tyr Leu Pro Gly Asp Gly Ala Tyr Arg Asp Gln Asp Gly Tyr Tyr 
            500                 505                 510         

Trp Ile Val Gly Arg Leu Asp Asp Val Ile Asn Val Ser Gly His Arg 
        515                 520                 525             

Ile Gly Thr Ala Glu Val Glu Ser Ala Leu Val Ala His Pro Ala Val 
    530                 535                 540                 

Ala Glu Ala Ala Val Ile Gly Arg Ala His Glu Val Lys Gly Gln Ala 
545                 550                 555                 560 

Ile Thr Ala Phe Val Ile Leu Lys Glu Gly His Thr Gly Ser Asp Asp 
                565                 570                 575     

Leu Val Ser Glu Leu Lys Gln Phe Val Val Glu Gln Ile Gly Ala Met 
            580                 585                 590         

Ala Arg Pro Glu Glu Ile Ile Phe Thr Ala Asp Leu Pro Lys Thr Arg 
        595                 600                 605             

Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Ile Ala Glu Gly Arg 
    610                 615                 620                 

Val Val Gly Asp Thr Thr Thr Leu Ala Asp Pro Ala Val Val Glu Gln 
625                 630                 635                 640 

Leu Lys Ser Gln Tyr Lys Asp Gln Glu 
                645                 

<210>   11
<211>   649
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   11
Met Thr Pro Asn Asp Leu Asp Ala Leu Leu Arg Glu Thr Arg Thr Phe 
                5                   10                  15      

Ala Pro Ser Glu Glu Phe Arg Arg Gln Ala Asn Tyr Lys Asp Glu Ser 
            20                  25                  30          

Ile Tyr Glu Glu Ala Ala Arg Asp Pro Glu Gly Tyr Trp Ala Lys Gln 
        35                  40                  45              

Ala Glu His Ile Thr Trp Phe His Glu Phe Glu Ser Val Cys Arg Trp 
    50                  55                  60                  

Asp Pro Pro His Ala Gln Trp Phe Ile Gly Gly Lys Leu Asn Ala Ala 
65                  70                  75                  80  

Tyr Asn Cys Val Asp Arg His Thr Leu Thr His Arg Lys Asn Lys Ala 
                85                  90                  95      

Ala Ile Ile Trp Glu Gly Glu Pro Gly Asp Ser Arg Val Leu Thr Tyr 
            100                 105                 110         

Asp Met Leu Arg Arg Glu Val Asp Lys Ala Ala His Met Leu Thr Gln 
        115                 120                 125             

Leu Gly Val Lys Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Val 
    130                 135                 140                 

Pro Glu Leu Pro Ile Ala Met Leu Ala Cys Ala Lys Ile Gly Ala Met 
145                 150                 155                 160 

His Ser Val Val Phe Gly Gly Phe Ser Ala Gln Ala Leu Lys Asp Arg 
                165                 170                 175     

Ile Leu Asp Ala Gly Ser Lys Leu Leu Ile Thr Ala Asp Gly Gly Trp 
            180                 185                 190         

Arg Arg Gly Lys Val Leu Pro Leu Lys Gln Asn Ala Asp Glu Ala Val 
        195                 200                 205             

Val Gly Thr Pro Ile Glu Lys Val Val Val Val Gln Arg Ile Gly Glu 
    210                 215                 220                 

Ala Ala Gln Ala Ala Met Asp Pro Ala Arg Asp Val Trp Trp His Glu 
225                 230                 235                 240 

Ala Met Gln Ser Ala Pro Thr Lys Pro Phe Pro Ala Glu Pro Met Asp 
                245                 250                 255     

Ala Glu Asp Tyr Leu Phe Leu Leu Tyr Thr Ser Gly Thr Thr Gly Lys 
            260                 265                 270         

Pro Lys Gly Ile Val His Ser Thr Gly Gly Tyr Leu Val Gly Val Asn 
        275                 280                 285             

Thr Ser Met Arg Thr Val Phe Asp Leu Lys Asp Glu Asp Val Phe Phe 
    290                 295                 300                 

Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Thr Tyr Ile Val Tyr 
305                 310                 315                 320 

Gly Pro Leu Ser Ala Gly Ala Thr Val Val Met Tyr Glu Gly Ser Pro 
                325                 330                 335     

Asp Tyr Pro Asp Arg Asp Arg Tyr Trp Ala Ile Val Glu Lys Tyr Gly 
            340                 345                 350         

Ala Thr Ile Leu Tyr Thr Ala Pro Thr Ser Ile Arg Met Phe Met Lys 
        355                 360                 365             

Trp Gly Pro Gln Tyr Val Glu Lys His Asp Leu Ser Thr Leu Arg Leu 
    370                 375                 380                 

Leu Gly Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Met Trp Tyr 
385                 390                 395                 400 

His Lys Tyr Val Gly Gln Glu Arg Cys Pro Ile Val Asp Thr Trp Trp 
                405                 410                 415     

Gln Thr Glu Thr Gly Cys Ala Met Ile Ala Pro Leu Pro Gly Ile Ile 
            420                 425                 430         

Thr Thr Lys Pro Gly Ser Ala Thr Lys Pro Val Pro Gly Ile Ser Val 
        435                 440                 445             

Asp Ile Leu Asp Asp Asp Gly Asn Pro Val Pro Pro Gly His Gly Gly 
    450                 455                 460                 

Asn Leu Val Ile Thr Lys Pro Trp Pro Ser Met Leu Arg Thr Val Trp 
465                 470                 475                 480 

Gly Asp Asp Glu Arg Phe Arg Lys Thr Tyr Phe Glu Lys Phe Glu Gly 
                485                 490                 495     

Ile Tyr Leu Pro Gly Asp Gly Ala Tyr Arg Asp Gln Asp Gly Tyr Tyr 
            500                 505                 510         

Trp Ile Val Gly Arg Leu Asp Asp Val Ile Asn Val Ser Gly His Arg 
        515                 520                 525             

Ile Gly Thr Ala Glu Val Glu Ser Ala Leu Val Ala His Pro Ala Val 
    530                 535                 540                 

Ala Glu Ala Ala Val Ile Gly Arg Ala His Glu Val Lys Gly Gln Ala 
545                 550                 555                 560 

Ile Thr Ala Phe Val Ile Leu Lys Glu Gly His Thr Gly Ser Asp Asp 
                565                 570                 575     

Leu Val Ser Glu Leu Lys Gln Phe Val Val Glu Gln Ile Gly Ala Met 
            580                 585                 590         

Ala Arg Pro Glu Glu Ile Ile Phe Thr Ala Asp Leu Pro Lys Thr Arg 
        595                 600                 605             

Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Ile Ala Glu Gly Arg 
    610                 615                 620                 

Val Val Gly Asp Thr Thr Thr Leu Ala Asp Pro Ala Val Val Glu Gln 
625                 630                 635                 640 

Leu Lys Ser Gln Tyr Lys Asp Gln Glu 
                645                 

<210>   12
<211>   649
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   12
Met Thr Pro Asn Asp Leu Asp Ala Leu Leu Arg Glu Thr Arg Thr Phe 
                5                   10                  15      

Ala Pro Ser Glu Glu Phe Arg Arg Gln Ala Asn Tyr Lys Asp Glu Ser 
            20                  25                  30          

Ile Tyr Glu Asp Ala Ala Arg Asp Pro Glu Gly Tyr Trp Ala Lys Gln 
        35                  40                  45              

Ala Glu His Ile Thr Trp Phe His Glu Phe Glu Ser Val Cys Arg Trp 
    50                  55                  60                  

Asp Pro Pro His Ala Gln Trp Phe Ile Gly Gly Lys Leu Asn Ala Ala 
65                  70                  75                  80  

Tyr Asn Cys Val Asp Arg His Thr Leu Thr His Arg Lys Asn Lys Ala 
                85                  90                  95      

Ala Ile Ile Trp Glu Gly Glu Pro Gly Asp Ser Arg Val Leu Thr Tyr 
            100                 105                 110         

Asp Met Leu Arg Arg Glu Val Asp Lys Ala Ala His Met Leu Thr Gln 
        115                 120                 125             

Leu Gly Val Lys Lys Gly Asp Arg Val Thr Ile Tyr Leu Pro Met Val 
    130                 135                 140                 

Pro Glu Leu Pro Ile Ala Met Leu Ala Cys Ala Lys Ile Gly Ala Met 
145                 150                 155                 160 

His Ser Val Val Phe Gly Gly Phe Ser Ala Gln Ala Leu Lys Asp Arg 
                165                 170                 175     

Ile Leu Asp Ala Gly Ser Lys Leu Leu Ile Thr Ala Asp Gly Gly Trp 
            180                 185                 190         

Arg Arg Gly Lys Val Ile Pro Leu Lys Gln Asn Ala Asp Glu Ala Val 
        195                 200                 205             

Val Gly Thr Pro Ile Glu Lys Val Val Val Val Gln Arg Ile Gly Glu 
    210                 215                 220                 

Ala Ala Gln Ala Ala Met Asp Pro Ala Arg Asp Val Trp Trp His Glu 
225                 230                 235                 240 

Ala Met Gln Ser Ala Pro Thr Lys Pro Phe Pro Ala Glu Pro Met Asp 
                245                 250                 255     

Ala Glu Asp Tyr Leu Phe Leu Leu Tyr Thr Ser Gly Thr Thr Gly Lys 
            260                 265                 270         

Pro Lys Gly Ile Val His Ser Thr Gly Gly Tyr Leu Val Gly Val Asn 
        275                 280                 285             

Thr Ser Met Arg Thr Val Phe Asp Leu Lys Asp Glu Asp Val Phe Phe 
    290                 295                 300                 

Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Thr Tyr Ile Val Tyr 
305                 310                 315                 320 

Gly Pro Leu Ser Ala Gly Ala Thr Val Val Met Tyr Glu Gly Ser Pro 
                325                 330                 335     

Asp Tyr Pro Asp Arg Asp Arg Tyr Trp Ala Ile Val Glu Lys Tyr Gly 
            340                 345                 350         

Ala Thr Ile Leu Tyr Thr Ala Pro Thr Ser Ile Arg Met Phe Met Lys 
        355                 360                 365             

Trp Gly Pro Gln Tyr Val Glu Lys His Asp Leu Ser Thr Leu Arg Leu 
    370                 375                 380                 

Leu Gly Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Met Trp Tyr 
385                 390                 395                 400 

His Lys Tyr Val Gly Gln Glu Arg Cys Pro Ile Val Asp Thr Trp Trp 
                405                 410                 415     

Gln Thr Glu Thr Gly Cys Ala Met Ile Ala Pro Leu Pro Gly Ile Ile 
            420                 425                 430         

Thr Thr Lys Pro Gly Ser Ala Thr Lys Pro Val Pro Gly Ile Ser Val 
        435                 440                 445             

Asp Ile Leu Asp Asp Asp Gly Asn Pro Val Pro Pro Gly His Gly Gly 
    450                 455                 460                 

Asn Leu Val Ile Thr Lys Pro Trp Pro Ser Met Leu Arg Thr Val Trp 
465                 470                 475                 480 

Gly Asp Asp Glu Arg Phe Arg Lys Thr Tyr Phe Glu Lys Phe Glu Gly 
                485                 490                 495     

Ile Tyr Leu Pro Gly Asp Gly Ala Tyr Arg Asp Gln Asp Gly Tyr Tyr 
            500                 505                 510         

Trp Ile Val Gly Arg Leu Asp Asp Val Ile Asn Val Ser Gly His Arg 
        515                 520                 525             

Ile Gly Thr Ala Glu Val Glu Ser Ala Leu Val Ala His Pro Ala Val 
    530                 535                 540                 

Ala Glu Ala Ala Val Ile Gly Arg Ala His Glu Val Lys Gly Gln Ala 
545                 550                 555                 560 

Ile Thr Ala Phe Val Ile Leu Lys Glu Gly His Thr Gly Ser Asp Asp 
                565                 570                 575     

Leu Val Ser Glu Leu Lys Gln Phe Val Val Glu Gln Ile Gly Ala Met 
            580                 585                 590         

Ala Arg Pro Glu Glu Ile Ile Phe Thr Ala Asp Leu Pro Lys Thr Arg 
        595                 600                 605             

Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Ile Ala Glu Gly Arg 
    610                 615                 620                 

Val Val Gly Asp Thr Thr Thr Leu Ala Asp Pro Ala Val Val Glu Gln 
625                 630                 635                 640 

Leu Lys Ser Gln Tyr Lys Asp Gln Glu 
                645                 

<210>   13
<211>   1950
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   13
atgaccccga atgatctcga cgcactactc cgtgaaaccc gcacctttgc cccgtccgaa       60

gaatttcgcc gccaagcgaa ttacaaggat gaaagcattt acgaggaagc tgctcgtgat      120

ccagagggtt actgggcgaa acaagccgaa catattactt ggttccatga atttgaaagc      180

gtttgcaggt gggatccgcc gcacgcgcaa tggttcatcg gcggcaagct gaacgccgcg      240

tataactgcg tggaccgtca caccctcact caccgcaaga ataaggcggc catcatctgg      300

gaaggcgagc caggcgacag ccgcgtcctc acgtacgaca tgttgcgccg cgaagtcgat      360

aaggccgcac acatgctcac ccagcttggg gtcaaaaagg gcgatcgcgt caccatctac      420

ctgcccatgg tgcccgagct ccccattgcg atgctcgcgt gcgccaaaat cggcgccatg      480

cattccgtcg tgttcggcgg attttccgcg caggcgctga aggatcgcat cctggacgcc      540

ggcagcaagc tgctcatcac ggcggacgga ggctggcgcc gcggcaaggt cattccgctc      600

aagcagaacg cggacgaagc cgtcgtggga acgcccatcg agaaggttgt ggtcgtccag      660

cggatcggcg aagcggctca ggcagccatg gatccggcgc gagacgtctg gtggcacgaa      720

gccatgcaga gcgcgccgac caagcccttc ccggctgagc ccatggacgc ggaagactac      780

ctgttcctgc tctacacgtc tggcaccacg ggcaagccga agggcattgt ccacagcacg      840

ggcggatacc tggtgggcgt caacacgtcc atgcggaccg tgttcgatct gaaggacgaa      900

gacgtgttct tctgcacggc ggacatcggc tggatcaccg gccacacgta catcgtgtac      960

ggcccgctgt cggccggcgc gacggtcgtc atgtacgagg gatcgcccga ttatcccgat     1020

cgcgaccggt actgggccat cgtcgagaag tacggcgcga ccatcctgta caccgcgccg     1080

acatccatcc gcatgttcat gaaatggggt ccccagtacg tcgaaaagca cgatctcagc     1140

acgctccggc tgctcggatc tgtcggcgag cccattaacc cggaggcgtg gatgtggtac     1200

cacaagtacg tcggccagga gcggtgcccc atcgtggaca cctggtggca gacggaaacc     1260

ggttgcgcga tgatcgcgcc tctgccaggc attatcacca ccaagccggg ttctgccacc     1320

aagcccgtgc ccggcatctc cgtcgatatc attgacgacg acggcaatcc ggtgccgccg     1380

gggcatggcg gaaatctcgt catcaccaag ccctggccgt ccatgctgcg cacggtgtgg     1440

ggcgatgacg agcgcttccg caagacgtac ttcgagaagt tcgagggcat ctacctgcct     1500

ggggacggcg cgtaccgaga tcaggatggc tactactgga ttgtcggacg gctggacgac     1560

gtgatcaacg tgtcgggcca ccgcattggc actgcggaag tggagagcgc gctggtggct     1620

catcccgctg tcgccgaggc ggccgtgatc gggcgcgccc acgaagtcaa ggggcaggcc     1680

atcaccgcgt ttgtcatcct caaagagggc cacaccggtt cggacgatct cgtctcggaa     1740

ctgaagcaat tcgtcgtcga gcaaatcggc gccatggcgc ggccggagga gatcatcttc     1800

acggccgatc tgcccaagac gcgcagcggc aagattatgc gccgcctgtt gcgcgacatc     1860

gcggaaggcc gtgtggtcgg cgacaccacc accctggccg atccggccgt cgtggagcaa     1920

ctgaaatcgc agtacaagga tcaggaatga                                      1950


<210>   14
<211>   1950
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   14
atgaccccga atgatctcga cgcactactc cgtgaaaccc gcacctttgc cccgtccgaa       60

gaatttcgcc gccaagcgaa ttacaaggat gaaagcattt acgaggaagc tgctcgtgat      120

ccagagggtt actgggcgaa acaagccgaa catattactt ggttccatga atttgaaagc      180

gtttgcaggt gggatccgcc gcacgcgcaa tggttcatcg gcggcaagct gaacgccgcg      240

tataactgcg tggaccgtca caccctcact caccgcaaga ataaggcggc catcatctgg      300

gaaggcgagc caggcgacag ccgcgtcctc acgtacgaca tgttgcgccg cgaagtcgat      360

aaggccgcac acatgctcac ccagcttggg gtcaaaaagg gcgatcgcgt caccatctac      420

ctgcccatgg tgcccgagct ccccattgcg atgctcgcgt gcgccaaaat cggcgccatg      480

cattccgtcg tgttcggcgg attttccgcg caggcgctga aggatcgcat cctggacgcc      540

ggcagcaagc tgctcatcac ggcggacgga ggctggcgcc gcggcaaggt cattccgctc      600

aagcagaacg cggacgaagc cgtcgtggga acgcccatcg agaaggttgt ggtcgtccag      660

cggatcggcg aagcggctca ggcagccatg gatccggcgc gagacgtctg gtggcacgaa      720

gccatgcaga gcgcgccgac caagcccttc ccggctgagc ccatggacgc ggaagactac      780

ctgttcctgc tctacacgtc tggcaccacg ggcaagccga agggcattgt ccacagcacg      840

ggcggatacc tggtgggcgt caacacgtcc atgcggaccg tgttcgatct gaaggacgaa      900

gacgtgttct tctgcacggc ggacatcggc tggatcaccg gccacacgta catcgtgtac      960

ggcccgctgt cggccggcgc gacggtcgtc atgtacgagg gatcgcccga ttatcccgat     1020

cgcgaccggt actgggccat cgtcgagaag tacggcgcga ccatcctgta caccgcgccg     1080

acatccatcc gcatgttcat gaaatggggt ccccagtacg tcgaaaagca cgatctcagc     1140

acgctccggc tgctcggatc tgtcggcgag cccattaacc cggaggcgtg gatgtggtac     1200

cacaagtacg tcggccagga gcggtgcccc atcgtggaca cctggtggca gacggaaacc     1260

ggttgcgcga tgatcgcgcc tctgccaggc attatcacca ccaagccggg ttctgccacc     1320

aagcccgtgc ccggcatctc cgtcgatatc cttgacgacg acggcaatcc ggtgccgccg     1380

gggcatggcg gaaatctcgt catcaccaag ccctggccgt ccatgctgcg cacggtgtgg     1440

ggcgatgacg agcgcttccg caagacgtac ttcgagaagt tcgagggcat ctacctgcct     1500

ggggacggcg cgtaccgaga tcaggatggc tactactgga ttattggacg gctggacgac     1560

gtgatcaacg tgtcgggcca ccgcattggc actgcggaag tggagagcgc gctggtggct     1620

catcccgctg tcgccgaggc ggccgtgatc gggcgcgccc acgaagtcaa ggggcaggcc     1680

atcaccgcgt ttgtcatcct caaagagggc cacaccggtt cggacgatct cgtctcggaa     1740

ctgaagcaat tcgtcgtcga gcaaatcggc gccatggcgc ggccggagga gatcatcttc     1800

acggccgatc tgcccaagac gcgcagcggc aagattatgc gccgcctgtt gcgcgacatc     1860

gcggaaggcc gtgtggtcgg cgacaccacc accctggccg atccggccgt cgtggagcaa     1920

ctgaaatcgc agtacaagga tcaggaatga                                      1950


<210>   15
<211>   1950
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   15
atgaccccga atgatctcga cgcactactc cgtgaaaccc gcacctttgc cccgtccgaa       60

gaatttcgcc gccaagcgaa ttacaaggat gaaagcattt acgaggaagc tgctcgtgat      120

ccagagggtt actgggcgaa acaagccgaa catattactt ggttccatga atttgaaagc      180

gtttgcaggt gggatccgcc gcacgcgcaa tggttcatcg gcggcaagct gaacgccgcg      240

tataactgcg tggaccgtca caccctcact caccgcaaga ataaggcggc catcatctgg      300

gaaggcgagc caggcgacag ccgcgtcctc acgtacgaca tgttgcgccg cgaagtcgat      360

aaggccgcac acatgctcac ccagcttggg gtcaaaaagg gcgatcgcgt caccatctac      420

ctgcccatgg tgcccgagct ccccattgcg atgctcgcgt gcgccaaaat cggcgccatg      480

cattccgtcg tgttcggcgg attttccgcg caggcgctga aggatcgcat cctggacgcc      540

ggcagcaagc tgctcatcac ggcggacgga ggctggcgcc gcggcaaggt cattccgctc      600

aagcagaacg cggacgaagc cgtcgtggga acgcccatcg agaaggttgt ggtcgtccag      660

cggatcggcg aagcggctca ggcagccatg gatccggcgc gagacgtctg gtggcacgaa      720

gccatgcaga gcgcgccgac caagcccttc ccggctgagc ccatggacgc ggaagactac      780

ctgttcctgc tctacacgtc tggcaccacg ggcaagccga agggcattgt ccacagcacg      840

ggcggatacc tggtgggcgt caacacgtcc atgcggaccg tgttcgatct gaaggacgaa      900

gacgtgttct tctgcacggc ggacatcggc tggatcaccg gccacacgta catcgtgtac      960

ggcccgctgt cggccggcgc gacggtcgtc atgtacgagg gatcgcccga ttatcccgat     1020

cgcgaccggt actgggccat cgtcgagaag tacggcgcga ccatcctgta caccgcgccg     1080

acatccatcc gcatgttcat gaaatggggt ccccagtacg tcgaaaagca cgaactcagc     1140

acgctccggc tgctcggatc tgtcggcgag cccattaacc cggaggcgtg gatgtggtac     1200

cacaagtacg tcggccagga gcggtgcccc atcgtggaca cctggtggca gacggaaacc     1260

ggttgcgcga tgatcgcgcc tctgccaggc attatcacca ccaagccggg ttctgccacc     1320

aagcccgtgc ccggcatctc cgtcgatatc cttgacgacg acggcaatcc ggtgccgccg     1380

gggcatggcg gaaatctcgt catcaccaag ccctggccgt ccatgctgcg cacggtgtgg     1440

ggcgatgacg agcgcttccg caagacgtac ttcgagaagt tcgagggcat ctacctgcct     1500

ggggacggcg cgtaccgaga tcaggatggc tactactgga ttgtcggacg gctggacgac     1560

gtgatcaacg tgtcgggcca ccgcattggc actgcggaag tggagagcgc gctggtggct     1620

catcccgctg tcgccgaggc ggccgtgatc gggcgcgccc acgaagtcaa ggggcaggcc     1680

atcaccgcgt ttgtcatcct caaagagggc cacaccggtt cggacgatct cgtctcggaa     1740

ctgaagcaat tcgtcgtcga gcaaatcggc gccatggcgc ggccggagga gatcatcttc     1800

acggccgatc tgcccaagac gcgcagcggc aagattatgc gccgcctgtt gcgcgacatc     1860

gcggaaggcc gtgtggtcgg cgacaccacc accctggccg atccggccgt cgtggagcaa     1920

ctgaaatcgc agtacaagga tcaggaatga                                      1950


<210>   16
<211>   1950
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   16
atgaccccga atgatctcga cgcactactc cgtgaaaccc gcacctttgc cccgtccgaa       60

gaatttcgcc gccaagcgaa ttacaaggat gaaagcattt acgaggaagc tgctcgtgat      120

ccagagggtt actgggcgaa acaagccgaa catattactt ggttccatga atttgaaagc      180

gtttgcaggt gggatccgcc gcacgcgcaa tggttcatcg gcggcaagct gaacgccgcg      240

tataactgcg tggaccgtca caccctcact caccgcaaga ataaggcggc catcatctgg      300

gaaggcgagc caggcgacag ccgcgtcctc acgtacgaca tgttgcgccg cgaagtcgat      360

aaggccgcac acatgctcac ccagcttggg gtcaaaaagg gcgatcgcgt caccatctac      420

ctgcccatgg tgcccgagct ccccattgcg atgctcgcgt gcgccaaaat cggcgccatg      480

cattccgtcg tgttcggcgg attttccgcg caggcgctga aggatcgcat cctggacgcc      540

ggcagcaagc tgctcatcac ggcggacgga ggctggcgcc gcggcaaggt cttaccgctc      600

aagcagaacg cggacgaagc cgtcgtggga acgcccatcg agaaggttgt ggtcgtccag      660

cggatcggcg aagcggctca ggcagccatg gatccggcgc gagacgtctg gtggcacgaa      720

gccatgcaga gcgcgccgac caagcccttc ccggctgagc ccatggacgc ggaagactac      780

ctgttcctgc tctacacgtc tggcaccacg ggcaagccga agggcattgt ccacagcacg      840

ggcggatacc tggtgggcgt caacacgtcc atgcggaccg tgttcgatct gaaggacgaa      900

gacgtgttct tctgcacggc ggacatcggc tggatcaccg gccacacgta catcgtgtac      960

ggcccgctgt cggccggcgc gacggtcgtc atgtacgagg gatcgcccga ttatcccgat     1020

cgcgaccggt actgggccat cgtcgagaag tacggcgcga ccatcctgta caccgcgccg     1080

acatccatcc gcatgttcat gaaatggggt ccccagtacg tcgaaaagca cgatctcagc     1140

acgctccggc tgctcggatc tgtcggcgag cccattaacc cggaggcgtg gatgtggtac     1200

cacaagtacg tcggccagga gcggtgcccc atcgtggaca cctggtggca gacggaaacc     1260

ggttgcgcga tgatcgcgcc tctgccaggc attatcacca ccaagccggg ttctgccacc     1320

aagcccgtgc ccggcatctc cgtcgatatc cttgacgacg acggcaatcc ggtgccgccg     1380

gggcatggcg gaaatctcgt catcaccaag ccctggccgt ccatgctgcg cacggtgtgg     1440

ggcgatgacg agcgcttccg caagacgtac ttcgagaagt tcgagggcat ctacctgcct     1500

ggggacggcg cgtaccgaga tcaggatggc tactactgga ttgtcggacg gctggacgac     1560

gtgatcaacg tgtcgggcca ccgcattggc actgcggaag tggagagcgc gctggtggct     1620

catcccgctg tcgccgaggc ggccgtgatc gggcgcgccc acgaagtcaa ggggcaggcc     1680

atcaccgcgt ttgtcatcct caaagagggc cacaccggtt cggacgatct cgtctcggaa     1740

ctgaagcaat tcgtcgtcga gcaaatcggc gccatggcgc ggccggagga gatcatcttc     1800

acggccgatc tgcccaagac gcgcagcggc aagattatgc gccgcctgtt gcgcgacatc     1860

gcggaaggcc gtgtggtcgg cgacaccacc accctggccg atccggccgt cgtggagcaa     1920

ctgaaatcgc agtacaagga tcaggaatga                                      1950


<210>   17
<211>   1950
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   17
atgaccccga atgatctcga cgcactactc cgtgaaaccc gcacctttgc cccgtccgaa       60

gaatttcgcc gccaagcgaa ttacaaggat gaaagcattt acgaggatgc tgctcgtgat      120

ccagagggtt actgggcgaa acaagccgaa catattactt ggttccatga atttgaaagc      180

gtttgcaggt gggatccgcc gcacgcgcaa tggttcatcg gcggcaagct gaacgccgcg      240

tataactgcg tggaccgtca caccctcact caccgcaaga ataaggcggc catcatctgg      300

gaaggcgagc caggcgacag ccgcgtcctc acgtacgaca tgttgcgccg cgaagtcgat      360

aaggccgcac acatgctcac ccagcttggg gtcaaaaagg gcgatcgcgt caccatctac      420

ctgcccatgg tgcccgagct ccccattgcg atgctcgcgt gcgccaaaat cggcgccatg      480

cattccgtcg tgttcggcgg attttccgcg caggcgctga aggatcgcat cctggacgcc      540

ggcagcaagc tgctcatcac ggcggacgga ggctggcgcc gcggcaaggt cattccgctc      600

aagcagaacg cggacgaagc cgtcgtggga acgcccatcg agaaggttgt ggtcgtccag      660

cggatcggcg aagcggctca ggcagccatg gatccggcgc gagacgtctg gtggcacgaa      720

gccatgcaga gcgcgccgac caagcccttc ccggctgagc ccatggacgc ggaagactac      780

ctgttcctgc tctacacgtc tggcaccacg ggcaagccga agggcattgt ccacagcacg      840

ggcggatacc tggtgggcgt caacacgtcc atgcggaccg tgttcgatct gaaggacgaa      900

gacgtgttct tctgcacggc ggacatcggc tggatcaccg gccacacgta catcgtgtac      960

ggcccgctgt cggccggcgc gacggtcgtc atgtacgagg gatcgcccga ttatcccgat     1020

cgcgaccggt actgggccat cgtcgagaag tacggcgcga ccatcctgta caccgcgccg     1080

acatccatcc gcatgttcat gaaatggggt ccccagtacg tcgaaaagca cgatctcagc     1140

acgctccggc tgctcggatc tgtcggcgag cccattaacc cggaggcgtg gatgtggtac     1200

cacaagtacg tcggccagga gcggtgcccc atcgtggaca cctggtggca gacggaaacc     1260

ggttgcgcga tgatcgcgcc tctgccaggc attatcacca ccaagccggg ttctgccacc     1320

aagcccgtgc ccggcatctc cgtcgatatc cttgacgacg acggcaatcc ggtgccgccg     1380

gggcatggcg gaaatctcgt catcaccaag ccctggccgt ccatgctgcg cacggtgtgg     1440

ggcgatgacg agcgcttccg caagacgtac ttcgagaagt tcgagggcat ctacctgcct     1500

ggggacggcg cgtaccgaga tcaggatggc tactactgga ttgtcggacg gctggacgac     1560

gtgatcaacg tgtcgggcca ccgcattggc actgcggaag tggagagcgc gctggtggct     1620

catcccgctg tcgccgaggc ggccgtgatc gggcgcgccc acgaagtcaa ggggcaggcc     1680

atcaccgcgt ttgtcatcct caaagagggc cacaccggtt cggacgatct cgtctcggaa     1740

ctgaagcaat tcgtcgtcga gcaaatcggc gccatggcgc ggccggagga gatcatcttc     1800

acggccgatc tgcccaagac gcgcagcggc aagattatgc gccgcctgtt gcgcgacatc     1860

gcggaaggcc gtgtggtcgg cgacaccacc accctggccg atccggccgt cgtggagcaa     1920

ctgaaatcgc agtacaagga tcaggaatga                                      1950


<210>   18
<211>   112
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   18
Met Arg Arg Thr Ala Ser Thr Asp Pro Arg Arg Pro Gln Gly Leu Ala 
                5                   10                  15      

Arg Thr Lys Phe Thr Ser Ile Asn Lys Arg Arg Asn Arg Leu Met Gln 
            20                  25                  30          

Leu Asp Met Val Lys Ala Ile Tyr Asp Ile Ala Val Ala Leu Leu Leu 
        35                  40                  45              

Gly Leu Ala Ala Val Gly Ser Gly Val Gly Asp Gly Met Val Met Ser 
    50                  55                  60                  

Lys Tyr Val Glu Gly Val Ala Arg Gln Pro Glu Ala Arg Gly Ser Ile 
65                  70                  75                  80  

Phe Gly Ser Ala Leu Leu Gly Val Ala Leu Val Glu Ala Phe Pro Val 
                85                  90                  95      

Ile Ala Leu Ala Phe Gly Ile Ile Ile Leu Phe Thr Lys Gly Ala Phe 
            100                 105                 110         

<210>   19
<211>   339
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   19
ttgaggcgga cagccagcac tgaccctcgg cgtccgcaag ggcttgcgcg aacgaagttt       60

acgtccatca acaaaaggag gaacagactg atgcaactcg acatggtcaa agcgatttac      120

gacattgcgg tggcgctcct gctcggcttg gcggccgtcg gttccggcgt cggcgacggc      180

atggtcatga gcaagtacgt cgaaggcgtc gctcgccagc ctgaagcgcg cggttccatc      240

ttcggcagcg cgctccttgg tgtcgcgttg gtcgaggcct tcccggtcat cgcgctggca      300

ttcggtatca tcatcctctt cacgaagggc gcgttctga                             339


<210>   20
<211>   47
<212>   PRT
<213>   Pasteuria ramosa

<400>   20
Arg Tyr Leu Ser Gly Ile Thr Arg Gln Pro Glu Ala Ala Ser Gln Leu 
                5                   10                  15      

Leu Thr Ser Met Phe Ile Gly Ile Ala Leu Val Glu Ala Leu Pro Ile 
            20                  25                  30          

Ile Ala Val Ala Leu Gly Ile Ile Lys Leu Phe Ser Ile Gly Ser 
        35                  40                  45          

<210>   21
<211>   42
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   21
Lys Thr Val Glu Gly Ile Ala Arg Gln Pro Glu Leu Arg Gly Ala Leu 
                5                   10                  15      

Gln Gly Thr Met Phe Ile Gly Val Ala Leu Val Glu Ala Ile Pro Ile 
            20                  25                  30          

Ile Ala Ala Val Ile Ala Phe Met Val Met 
        35                  40          

<210>   22
<211>   45
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   22
Lys Thr Val Glu Gly Ile Ala Arg Gln Pro Glu Ala Lys Gly Ala Leu 
                5                   10                  15      

Gln Ser Thr Met Phe Ile Gly Val Gly Leu Ile Glu Ala Leu Pro Leu 
            20                  25                  30          

Leu Thr Trp Val Leu Ala Leu Leu Leu Met Phe Thr Lys 
        35                  40                  45  

<210>   23
<211>   42
<212>   PRT
<213>   Bacillus sp. B14905

<400>   23
Lys Thr Val Glu Gly Ile Ala Arg Gln Pro Glu Ala Arg Gly Val Leu 
                5                   10                  15      

Gln Thr Thr Met Phe Ile Gly Val Ala Leu Val Glu Ala Leu Pro Ile 
            20                  25                  30          

Ile Ala Val Val Val Ala Phe Ile Val Met 
        35                  40          

<210>   24
<211>   43
<212>   PRT
<213>   Thermosinus carboxydivorans Nor1

<400>   24
Lys Ala Ile Glu Gly Met Ala Arg Gln Pro Glu Ala Lys Gly Thr Ile 
                5                   10                  15      

Leu Val Asn Met Leu Ile Ser Val Gly Leu Ile Glu Ser Ile Pro Ile 
            20                  25                  30          

Ile Ala Ala Val Ile Ala Ile Val Leu Val Phe 
        35                  40              

<210>   25
<211>   112
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   25
Met Arg Arg Thr Ala Ser Thr Asp Pro Arg Arg Pro Gln Gly Leu Ala 
                5                   10                  15      

Arg Thr Lys Phe Thr Ser Ile Asn Lys Lys Arg Asn Arg Leu Met Gln 
            20                  25                  30          

Leu Asp Met Val Lys Ala Ile Tyr Asp Ile Ala Val Ala Leu Leu Leu 
        35                  40                  45              

Gly Leu Ala Ala Val Gly Ser Gly Val Gly Asp Gly Met Val Met Ser 
    50                  55                  60                  

Lys Tyr Val Glu Gly Val Ala Arg Gln Pro Glu Ala Arg Gly Ser Ile 
65                  70                  75                  80  

Phe Gly Ser Ala Leu Leu Gly Val Ala Leu Val Glu Ala Phe Pro Val 
                85                  90                  95      

Ile Ala Leu Ala Phe Gly Ile Ile Ile Leu Phe Thr Lys Gly Ala Phe 
            100                 105                 110         

<210>   26
<211>   112
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   26
Met Arg Arg Thr Ala Ser Thr Asp Pro Arg Arg Pro Gln Gly Leu Ala 
                5                   10                  15      

Arg Thr Lys Phe Thr Ser Ile Asn Lys Arg Arg Asn Arg Leu Met Gln 
            20                  25                  30          

Leu Asp Met Val Lys Ala Ile Tyr Asp Ile Ala Val Ala Leu Leu Leu 
        35                  40                  45              

Gly Leu Ala Ala Ile Gly Ser Gly Val Gly Asp Gly Met Val Met Ser 
    50                  55                  60                  

Lys Tyr Val Glu Gly Val Ala Arg Gln Pro Glu Ala Arg Gly Ser Ile 
65                  70                  75                  80  

Phe Gly Ser Ala Leu Leu Gly Val Ala Leu Val Glu Ala Phe Pro Val 
                85                  90                  95      

Ile Ala Leu Ala Phe Gly Ile Ile Ile Leu Phe Thr Lys Gly Ala Phe 
            100                 105                 110         

<210>   27
<211>   112
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   27
Met Arg Arg Thr Ala Ser Thr Asp Pro Arg Arg Pro Gln Gly Leu Ala 
                5                   10                  15      

Arg Thr Lys Phe Thr Ser Ile Asn Lys Arg Arg Asn Arg Leu Met Gln 
            20                  25                  30          

Leu Asp Met Val Lys Ala Ile Tyr Asp Ile Ala Val Ala Leu Leu Leu 
        35                  40                  45              

Gly Leu Ala Ala Val Gly Ser Gly Val Gly Asp Gly Met Val Met Ser 
    50                  55                  60                  

Lys Tyr Val Glu Gly Val Ala Arg Gln Pro Glu Ala Arg Gly Ser Ile 
65                  70                  75                  80  

Phe Gly Ser Ala Leu Leu Gly Val Ala Leu Val Glu Ala Phe Pro Val 
                85                  90                  95      

Ile Ala Leu Ala Phe Gly Ile Ile Ile Leu Phe Thr Arg Gly Ala Phe 
            100                 105                 110         

<210>   28
<211>   112
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   28
Met Arg Lys Thr Ala Ser Thr Asp Pro Arg Arg Pro Gln Gly Leu Ala 
                5                   10                  15      

Arg Thr Lys Phe Thr Ser Ile Asn Lys Arg Arg Asn Arg Leu Met Gln 
            20                  25                  30          

Leu Asp Met Val Lys Ala Ile Tyr Asp Ile Ala Val Ala Leu Leu Leu 
        35                  40                  45              

Gly Leu Ala Ala Val Gly Ser Gly Val Gly Asp Gly Met Val Met Ser 
    50                  55                  60                  

Lys Tyr Val Glu Gly Val Ala Arg Gln Pro Glu Ala Arg Gly Ser Ile 
65                  70                  75                  80  

Phe Gly Ser Ala Leu Leu Gly Val Ala Leu Val Glu Ala Phe Pro Val 
                85                  90                  95      

Ile Ala Leu Ala Phe Gly Ile Ile Ile Leu Phe Thr Lys Gly Ala Phe 
            100                 105                 110         

<210>   29
<211>   112
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   29
Met Arg Arg Thr Ala Ser Thr Asp Pro Arg Arg Pro Gln Gly Leu Ala 
                5                   10                  15      

Arg Thr Lys Phe Thr Ser Ile Asn Lys Arg Arg Asn Arg Leu Met Gln 
            20                  25                  30          

Leu Glu Met Val Lys Ala Ile Tyr Asp Ile Ala Val Ala Leu Leu Leu 
        35                  40                  45              

Gly Leu Ala Ala Val Gly Ser Gly Val Gly Asp Gly Met Val Met Ser 
    50                  55                  60                  

Lys Tyr Val Glu Gly Val Ala Arg Gln Pro Glu Ala Arg Gly Ser Ile 
65                  70                  75                  80  

Phe Gly Ser Ala Leu Leu Gly Val Ala Leu Val Glu Ala Phe Pro Val 
                85                  90                  95      

Ile Ala Leu Ala Phe Gly Ile Ile Ile Leu Phe Thr Lys Gly Ala Phe 
            100                 105                 110         

<210>   30
<211>   339
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   30
ttgaggcgga cagccagcac tgaccctcgg cgtccgcaag ggcttgcgcg aacgaagttt       60

acgtccatca acaaaaaaag gaacagactg atgcaactcg acatggtcaa agcgatttac      120

gacattgcgg tggcgctcct gctcggcttg gcggccgtcg gttccggcgt cggcgacggc      180

atggtcatga gcaagtacgt cgaaggcgtc gctcgccagc ctgaagcgcg cggttccatc      240

ttcggcagcg cgctccttgg tgtcgcgttg gtcgaggcct tcccggtcat cgcgctggca      300

ttcggtatca tcatcctctt cacgaagggc gcgttctga                             339


<210>   31
<211>   339
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   31
ttgaggcgga cagccagcac tgaccctcgg cgtccgcaag ggcttgcgcg aacgaagttt       60

acgtccatca acaaaaggag gaacagactg atgcaactcg acatggtcaa agcgatttac      120

gacattgcgg tggcgctcct gctcggcttg gcggccattg gttccggcgt cggcgacggc      180

atggtcatga gcaagtacgt cgaaggcgtc gctcgccagc ctgaagcgcg cggttccatc      240

ttcggcagcg cgctccttgg tgtcgcgttg gtcgaggcct tcccggtcat cgcgctggca      300

ttcggtatca tcatcctctt cacgaagggc gcgttctga                             339


<210>   32
<211>   339
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   32
ttgaggcgga cagccagcac tgaccctcgg cgtccgcaag ggcttgcgcg aacgaagttt       60

acgtccatca acaaaaggag gaacagactg atgcaactcg acatggtcaa agcgatttac      120

gacattgcgg tggcgctcct gctcggcttg gcggccgtcg gttccggcgt cggcgacggc      180

atggtcatga gcaagtacgt cgaaggcgtc gctcgccagc ctgaagcgcg cggttccatc      240

ttcggcagcg cgctccttgg tgtcgcgttg gtcgaggcct tcccggtcat cgcgctggca      300

ttcggtatca tcatcctctt cacgcgtggc gcgttctga                             339


<210>   33
<211>   339
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   33
ttgaggaaaa cagccagcac tgaccctcgg cgtccgcaag ggcttgcgcg aacgaagttt       60

acgtccatca acaaaaggag gaacagactg atgcaactcg acatggtcaa agcgatttac      120

gacattgcgg tggcgctcct gctcggcttg gcggccgtcg gttccggcgt cggcgacggc      180

atggtcatga gcaagtacgt cgaaggcgtc gctcgccagc ctgaagcgcg cggttccatc      240

ttcggcagcg cgctccttgg tgtcgcgttg gtcgaggcct tcccggtcat cgcgctggca      300

ttcggtatca tcatcctctt cacgaagggc gcgttctga                             339


<210>   34
<211>   339
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   34
ttgaggcgga cagccagcac tgaccctcgg cgtccgcaag ggcttgcgcg aacgaagttt       60

acgtccatca acaaaaggag gaacagactg atgcaactcg aaatggtcaa agcgatttac      120

gacattgcgg tggcgctcct gctcggcttg gcggccgtcg gttccggcgt cggcgacggc      180

atggtcatga gcaagtacgt cgaaggcgtc gctcgccagc ctgaagcgcg cggttccatc      240

ttcggcagcg cgctccttgg tgtcgcgttg gtcgaggcct tcccggtcat cgcgctggca      300

ttcggtatca tcatcctctt cacgaagggc gcgttctga                             339


<210>   35
<211>   447
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   35
Met Cys Ala Pro Cys Ser Asn Arg Lys Met Asn Val Asn Arg Gly Val 
                5                   10                  15      

Leu Ser His Ala Ala Leu Asp Glu Arg Ser Cys Ala Gly Leu Thr Thr 
            20                  25                  30          

Leu Leu Gln Gln Val Asp Pro Asp Val Ala Ser Ala Met Gln Ala Glu 
        35                  40                  45              

Leu Arg Arg Gln Gln Arg Asn Ile Glu Leu Ile Ala Ser Glu Asn Phe 
    50                  55                  60                  

Val Ser Glu Ala Val Leu Glu Ala Leu Gly Ser Val Leu Thr Asn Lys 
65                  70                  75                  80  

Tyr Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr 
                85                  90                  95      

Val Asp Val Val Glu Arg Ile Ala Ile Asp Arg Val Lys Glu Leu Phe 
            100                 105                 110         

Gly Ala Glu Tyr Ala Asn Val Gln Pro His Ser Gly Ser Gln Ala Asn 
        115                 120                 125             

Met Thr Val Tyr Phe Ser Val Leu Lys Pro Gly Asp Thr Val Leu Gly 
    130                 135                 140                 

Met Asn Leu Ala His Gly Gly His Leu Thr His Gly Ser Pro Val Asn 
145                 150                 155                 160 

Phe Ser Gly Gln Leu Tyr Lys Phe Val Ser Tyr Gly Val His Pro Glu 
                165                 170                 175     

Thr His Leu Ile Asp Tyr Asp Glu Val Leu Lys Val Ala Lys Glu His 
            180                 185                 190         

Arg Pro Lys Met Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Val Ile 
        195                 200                 205             

Asp Phe Lys Arg Met Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu 
    210                 215                 220                 

Met Val Asp Met Ala His Ile Ala Gly Leu Ile Ala Ala Gly Leu His 
225                 230                 235                 240 

Pro Ser Pro Val Pro Tyr Ala His Phe Val Thr Ser Thr Thr His Lys 
                245                 250                 255     

Thr Leu Arg Gly Pro Arg Gly Gly Phe Ile Leu Cys Gln Lys Asp Val 
            260                 265                 270         

Ala Lys Leu Ile Asp Lys Thr Asn Phe Pro Gly Val Gln Gly Gly Pro 
        275                 280                 285             

Leu Met His Val Ile Ala Ala Lys Ala Val Ala Phe Gly Glu Ala Leu 
    290                 295                 300                 

Lys Pro Glu Phe Lys Ala Tyr Gln Glu Gln Ile Val Lys Asn Ala Lys 
305                 310                 315                 320 

Ala Leu Ala Glu Ala Leu Lys Gly Tyr Gly Phe Arg Leu Val Ser Gly 
                325                 330                 335     

Gly Thr Asp Asn His Leu Met Leu Ile Asp Val Arg Ser Ala Gly Leu 
            340                 345                 350         

Thr Gly Lys Glu Ala Glu Arg Arg Leu Asp Glu Ile Gly Ile Thr Val 
        355                 360                 365             

Asn Lys Asn Ala Ile Pro Phe Asp Pro Glu Ser Pro Met Val Thr Ser 
    370                 375                 380                 

Gly Ile Arg Val Gly Thr Pro Ala Ala Thr Ser Arg Gly Met Asp Glu 
385                 390                 395                 400 

Gly Ala Met Gln Glu Ile Ala Glu Ile Phe Lys Leu Val Leu Leu Gly 
                405                 410                 415     

Asp Phe Ser Asp Glu Val Lys Arg Glu Ala Arg Ala Arg Val Asp Ser 
            420                 425                 430         

Leu Thr Asp Arg Phe Pro Leu Tyr Pro Thr Leu Ser Tyr Val Glu 
        435                 440                 445         

<210>   36
<211>   1344
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   36
ttgtgcgccc cgtgttcgaa ccgtaagatg aatgtgaatc gcggcgtcct ctcgcatgcg       60

gcgctggatg aaaggagttg cgcaggattg accacccttc tgcagcaggt tgacccggat      120

gtcgcgtctg cgatgcaggc cgagctccgt cggcagcagc ggaacatcga actcatcgct      180

tcagaaaact ttgtcagcga ggccgttctc gaggcccttg gatccgtcct gacgaacaaa      240

tacgccgaag gctacccagg ccggcgctat tacggcggct gcgagtacgt cgacgtggtc      300

gagcgcattg ccatcgatcg cgtcaaggag ctgttcggcg ccgagtacgc gaacgtccag      360

ccgcacagtg gttcgcaggc gaacatgacg gtctacttca gcgtcctcaa gccgggcgac      420

acggtgctcg gcatgaatct ggcgcacggc ggccacttga cgcatgggag ccccgtgaac      480

ttctccgggc agctttacaa gttcgtctcg tacggcgtcc acccggagac ccatctcatc      540

gattacgacg aggtgctcaa ggtcgcgaag gaacatcggc cgaagatgat cgtcgccggc      600

gcgagcgcgt acccgcgcgt catcgacttc aaacgcatgc gggagattgc ggacgaggtc      660

ggcgcgtatc tgatggtgga catggcgcac attgcgggcc tcattgccgc ggggcttcac      720

ccgtcccccg tgccgtacgc gcacttcgtg acgtccacga cgcacaagac gcttcggggt      780

ccgcgcggcg ggttcatcct ctgtcagaag gacgtcgcca agctcatcga caagacgaat      840

ttccccggcg tccagggcgg tcccctcatg cacgtgattg cagcgaaggc cgtcgccttc      900

ggggaagctt tgaaacccga attcaaggcg taccaggagc agattgtgaa gaacgcgaag      960

gcgctcgccg aagcgctcaa agggtacggg ttccgcctcg tgtccggcgg caccgacaac     1020

cacctgatgc tcatcgacgt ccgcagcgcg gggctgaccg gcaaagaagc cgagcggagg     1080

ctggacgaga tcggcatcac ggtcaacaag aacgccatcc cattcgatcc ggagagcccg     1140

atggtgacga gcggcatccg cgtcggcacg cctgccgcga cttcgcgcgg catggacgag     1200

ggcgcgatgc aggagattgc cgagatcttc aagctcgtgc tcctcggcga cttcagcgac     1260

gaggtgaagc gcgaggctcg cgctcgcgtc gacagcttga cggaccggtt tccgctctat     1320

ccgactttgt cctacgtcga atga                                            1344


<210>   37
<211>   416
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   37
Leu Asn Leu Arg Leu Lys Asp Val Asp Pro Glu Ile Phe Glu Ala Met 
                5                   10                  15      

Glu Lys Glu Leu Ser Arg Gln Arg Glu Lys Ile Glu Leu Ile Ala Ser 
            20                  25                  30          

Glu Asn Phe Val Ser Arg Ala Val Met Glu Ala Met Gly Ser His Leu 
        35                  40                  45              

Thr Asn Lys Tyr Ala Glu Gly Leu Pro Gly Lys Arg Tyr Tyr Gly Gly 
    50                  55                  60                  

Cys Glu Tyr Val Asp Val Val Glu Asn Leu Ala Arg Glu Arg Ala Lys 
65                  70                  75                  80  

Lys Leu Phe Gly Ala Glu His Val Asn Val Gln Pro His Ser Gly Ala 
                85                  90                  95      

Gln Ala Asn Met Ala Ala Tyr Met Ala Phe Leu Glu Pro Gly Asp Thr 
            100                 105                 110         

Val Leu Gly Met Asn Leu Ala His Gly Gly His Leu Thr His Gly Ser 
        115                 120                 125             

Pro Val Asn Phe Ser Gly Lys Leu Tyr Asn Phe Val Ser Tyr Gly Val 
    130                 135                 140                 

Glu Pro Asp Thr Glu Lys Ile Asn Tyr Glu Lys Val Phe Glu Leu Ala 
145                 150                 155                 160 

Tyr Lys His Lys Pro Lys Met Ile Val Ala Gly Ala Ser Ala Tyr Pro 
                165                 170                 175     

Arg Val Ile Asp Phe Lys His Leu Lys Glu Ile Ala Asp Glu Val Gly 
            180                 185                 190         

Ala Tyr Leu Met Val Asp Met Ala His Ile Ala Gly Leu Val Ala Ala 
        195                 200                 205             

Gly Leu His Pro Ser Pro Ile Pro Tyr Ala Asp Val Val Thr Thr Thr 
    210                 215                 220                 

Thr His Lys Thr Leu Arg Gly Pro Arg Gly Gly Val Ile Phe Cys Lys 
225                 230                 235                 240 

Ala Glu His Ala Ala Lys Ile Asp Lys Thr Val Phe Pro Gly Val Gln 
                245                 250                 255     

Gly Gly Pro Leu Met His Val Ile Ala Ala Lys Ala Val Ala Phe Lys 
            260                 265                 270         

Glu Ala Leu Ser Pro Glu Phe Arg Glu Tyr Gln Gln Gln Val Val Asn 
        275                 280                 285             

Asn Ala Lys Ala Leu Ala Glu Glu Leu Lys Lys Gln Gly Leu Arg Leu 
    290                 295                 300                 

Val Ser Gly Gly Thr Asp Asn His Leu Met Leu Val Asp Val Arg Pro 
305                 310                 315                 320 

Val Gly Leu Thr Gly Lys Arg Ala Glu Gln Leu Leu Asp Glu Ile Gly 
                325                 330                 335     

Val Thr Val Asn Lys Asn Ala Ile Pro Tyr Asp Pro Glu Ser Pro Asn 
            340                 345                 350         

Val Thr Ser Gly Ile Arg Ile Gly Thr Pro Ala Val Thr Thr Arg Gly 
        355                 360                 365             

Met Lys Glu Gly Glu Met Ala Glu Ile Ala Glu Ile Ile Ala Leu Val 
    370                 375                 380                 

Leu Lys Asn Pro Glu Asn Glu Asp Lys His Arg Glu Ala Ala Arg Lys 
385                 390                 395                 400 

Val Arg Asp Leu Leu Asn Arg Phe Pro Leu Tyr Asp Lys Leu Pro Tyr 
                405                 410                 415     

<210>   38
<211>   410
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   38
Leu Gln Ser Lys Asp Pro Lys Val Phe Glu Ala Val Gln Gln Glu Leu 
                5                   10                  15      

Gly Arg Gln Arg Asp Lys Ile Glu Leu Ile Ala Ser Glu Asn Phe Val 
            20                  25                  30          

Ser Glu Ala Val Met Glu Ala Gln Ser Ser Val Leu Thr Asn Lys Tyr 
        35                  40                  45              

Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr Val 
    50                  55                  60                  

Asp Ile Val Glu Asp Leu Ala Arg Asp Arg Ala Lys Glu Ile Phe Gly 
65                  70                  75                  80  

Gly Glu His Val Asn Val Gln Pro His Ser Gly Ala Gln Ala Asn Met 
                85                  90                  95      

Ala Val Tyr Phe Thr Ile Leu Glu His Gly Asp Thr Val Leu Gly Met 
            100                 105                 110         

Asn Leu Ser His Gly Gly His Leu Thr His Gly Ser Pro Val Asn Phe 
        115                 120                 125             

Ser Gly Ile Gln Tyr Asn Phe Val Glu Tyr Gly Val Asp Lys Glu Ser 
    130                 135                 140                 

Gln Arg Ile Asp Tyr Glu Glu Val Arg Arg Leu Ala Lys Glu His Gln 
145                 150                 155                 160 

Pro Lys Met Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Glu Ile Asp 
                165                 170                 175     

Phe Ala Lys Phe Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu Met 
            180                 185                 190         

Val Asp Met Ala His Ile Ala Gly Leu Val Ala Ala Gly Leu His Gln 
        195                 200                 205             

Asn Pro Val Pro His Ser His Phe Val Thr Thr Thr Thr His Lys Thr 
    210                 215                 220                 

Leu Arg Gly Pro Arg Gly Gly Met Ile Ile Cys Asn Glu Glu Phe Ala 
225                 230                 235                 240 

Lys Gln Ile Asp Lys Ser Ile Phe Pro Gly Ile Gln Gly Gly Pro Leu 
                245                 250                 255     

Met His Val Ile Ala Ala Lys Ala Val Ala Phe Gly Glu Ala Leu Gln 
            260                 265                 270         

Pro Glu Phe Lys Ser Tyr Gly Glu Ala Ile Ile Arg Asn Ala Lys Arg 
        275                 280                 285             

Leu Gly Glu Lys Leu Thr Ser Glu Gly Ile Asp Leu Val Ser Gly Gly 
    290                 295                 300                 

Thr Asp Asn His Leu Leu Leu Leu Asp Leu Arg Ser Leu Gly Leu Thr 
305                 310                 315                 320 

Gly Lys Val Ala Glu Lys Ala Leu Asp Asp Val Gly Ile Thr Thr Asn 
                325                 330                 335     

Lys Asn Thr Ile Pro Phe Asp Pro Glu Ser Pro Phe Val Thr Ser Gly 
            340                 345                 350         

Ile Arg Ile Gly Thr Ala Ala Val Thr Ser Arg Gly Leu Asp Glu Glu 
        355                 360                 365             

Ala Met Asp Glu Ile Gly Ala Thr Ile Ala Leu Thr Leu Lys Asn Val 
    370                 375                 380                 

Asp Asn Glu Glu Lys Met Asn Glu Ala Arg Glu Arg Val Asp Ala Leu 
385                 390                 395                 400 

Thr Ala Lys Phe Pro Met Tyr Pro Asn Leu 
                405                 410 

<210>   39
<211>   410
<212>   PRT
<213>   Exiguobacterium sibiricum 255-15

<400>   39
Thr Tyr Leu Lys Gln Gln Asp Glu Glu Leu Phe Ser Ala Met Arg Lys 
                5                   10                  15      

Glu Leu Lys Arg Gln Arg Asp Asn Ile Glu Leu Ile Ala Ser Glu Asn 
            20                  25                  30          

Phe Val Ser Gln Ala Val Met Glu Ala Gln Gly Ser Val Leu Thr Asn 
        35                  40                  45              

Lys Tyr Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu 
    50                  55                  60                  

Phe Val Asp Leu Ala Glu Asn Leu Ala Arg Asp Arg Ala Lys Ala Ile 
65                  70                  75                  80  

Phe Gly Ala Glu His Val Asn Val Gln Pro His Ser Gly Ala Gln Ala 
                85                  90                  95      

Asn Met Ala Val Tyr Phe Thr Ile Leu Asn Gln Gly Asp Thr Val Leu 
            100                 105                 110         

Gly Met Asn Leu Ser His Gly Gly His Leu Thr His Gly Ser Pro Val 
        115                 120                 125             

Asn Phe Ser Gly Val Gln Tyr Asn Phe Val Glu Tyr Gly Val Asp Pro 
    130                 135                 140                 

Glu Thr Glu Met Ile Asp Tyr Asp Val Val Ala Lys Leu Ala Glu Glu 
145                 150                 155                 160 

His Lys Pro Lys Leu Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Val 
                165                 170                 175     

Ile Asp Phe Lys Arg Phe Arg Glu Ile Ala Asp Ser Val Gly Ala Tyr 
            180                 185                 190         

Leu Met Val Asp Met Ala His Ile Ala Gly Leu Val Ala Ala Gly Leu 
        195                 200                 205             

His Pro Asn Pro Val Glu His Ala His Phe Val Thr Thr Thr Thr His 
    210                 215                 220                 

Lys Thr Leu Arg Gly Pro Arg Gly Gly Met Ile Leu Cys Lys Glu Glu 
225                 230                 235                 240 

His Ala Lys Ala Ile Asp Lys Ser Ile Phe Pro Gly Ile Gln Gly Gly 
                245                 250                 255     

Pro Leu Met His Val Ile Ala Ala Lys Ala Val Ala Phe Ala Glu Ala 
            260                 265                 270         

Leu Ala Pro Glu Phe Lys Asp Tyr Ile Glu Gln Val Val Ala Asn Ala 
        275                 280                 285             

Lys Val Leu Gly Glu Glu Leu Thr Ala Arg Gly Leu Arg Ile Val Ser 
    290                 295                 300                 

Gly Gly Thr Asp Asn His Leu Leu Leu Val Asp Leu Gln Pro Leu Gly 
305                 310                 315                 320 

Ile Thr Gly Lys Leu Ala Glu His Ala Leu Asp Glu Ala Gly Ile Thr 
                325                 330                 335     

Val Asn Lys Asn Thr Ile Pro Phe Asp Pro Ala Ser Pro Phe Val Thr 
            340                 345                 350         

Ser Gly Ile Arg Ile Gly Thr Ala Ala Met Thr Ser Arg Gly Phe Lys 
        355                 360                 365             

Glu Ala Glu Met Lys Gln Ile Ala Glu Leu Ile Glu Leu Val Leu Lys 
    370                 375                 380                 

Asn Pro Glu Asp Gln Glu Thr Leu Thr Ser Ala His Lys Gln Val Leu 
385                 390                 395                 400 

Ala Leu Thr Gly Arg Phe Pro Leu Tyr Pro 
                405                 410 

<210>   40
<211>   407
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   40
Leu Pro Gln Gln Asp Pro Gln Val Phe Ala Thr Ile Glu Gln Glu Arg 
                5                   10                  15      

Lys Arg Gln His Ala Lys Ile Glu Leu Ile Ala Ser Glu Asn Phe Val 
            20                  25                  30          

Ser Arg Ala Val Met Glu Ala Gln Gly Ser Val Met Thr Asn Lys Tyr 
        35                  40                  45              

Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr Val 
    50                  55                  60                  

Asp Val Val Glu Asp Leu Ala Arg Glu Arg Ala Lys Gln Leu Phe Gly 
65                  70                  75                  80  

Ala Glu His Ala Asn Val Gln Pro His Ser Gly Ala Gln Ala Asn Met 
                85                  90                  95      

Ala Val Tyr Phe Thr Val Leu Lys Pro Gly Asp Thr Val Leu Gly Met 
            100                 105                 110         

Asn Leu Ser His Gly Gly His Leu Thr His Gly Ser Pro Val Asn Phe 
        115                 120                 125             

Ser Gly Val Gln Tyr Asn Phe Val Glu Tyr Gly Val Asp Pro Glu Thr 
    130                 135                 140                 

His Val Ile Asp Tyr Asp Asp Val Arg Glu Lys Ala Arg Leu His Arg 
145                 150                 155                 160 

Pro Lys Leu Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Val Ile Asp 
                165                 170                 175     

Phe Ala Lys Phe Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu Met 
            180                 185                 190         

Val Asp Met Ala His Ile Ala Gly Leu Val Ala Ala Gly Leu His Pro 
        195                 200                 205             

Asn Pro Val Pro Tyr Ala His Phe Val Thr Thr Thr Thr His Lys Thr 
    210                 215                 220                 

Leu Arg Gly Pro Arg Gly Gly Met Ile Leu Cys Gln Glu Gln Phe Ala 
225                 230                 235                 240 

Lys Gln Ile Asp Lys Ser Ile Phe Pro Gly Ile Gln Gly Gly Pro Leu 
                245                 250                 255     

Met His Val Ile Ala Ala Lys Ala Val Ala Leu Gly Glu Ala Leu Gln 
            260                 265                 270         

Asp Asp Phe Lys Val Tyr Ala Lys Arg Ile Ile Asp Asn Ala Gln Arg 
        275                 280                 285             

Leu Ala Ala Ala Leu Gln Lys Glu Gly Phe Thr Leu Val Ser Gly Gly 
    290                 295                 300                 

Thr Asp Asn His Leu Leu Leu Val Asp Leu Arg Pro Gln Gln Leu Thr 
305                 310                 315                 320 

Gly Lys Thr Ala Glu Lys Val Leu Asp Glu Val Gly Ile Thr Val Asn 
                325                 330                 335     

Lys Asn Thr Ile Pro Tyr Asp Pro Glu Ser Pro Phe Val Thr Ser Gly 
            340                 345                 350         

Ile Arg Ile Gly Thr Ala Ala Val Thr Thr Arg Gly Phe Gly Leu Glu 
        355                 360                 365             

Glu Met Asp Glu Ile Ala Ser Leu Ile Gly Leu Val Leu Lys Asn Ile 
    370                 375                 380                 

Asp Asn Glu Gln Ala Leu Glu Glu Ala Arg Gln Arg Val Val Ala Leu 
385                 390                 395                 400 

Thr Glu Lys Phe Pro Leu Tyr 
                405         

<210>   41
<211>   407
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   41
Leu Pro Gln Gln Asp Pro Gln Val Phe Ala Ala Ile Glu Gln Glu Arg 
                5                   10                  15      

Lys Arg Gln His Ala Lys Ile Glu Leu Ile Ala Ser Glu Asn Phe Val 
            20                  25                  30          

Ser Arg Ala Val Met Glu Ala Gln Gly Ser Val Leu Thr Asn Lys Tyr 
        35                  40                  45              

Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr Val 
    50                  55                  60                  

Asp Ile Val Glu Asp Leu Ala Arg Glu Arg Ala Lys Gln Leu Phe Gly 
65                  70                  75                  80  

Ala Glu His Val Asn Val Gln Pro His Ser Gly Ala Gln Ala Asn Met 
                85                  90                  95      

Ala Val Tyr Phe Thr Val Leu Glu His Gly Asp Thr Val Leu Gly Met 
            100                 105                 110         

Asn Leu Ser His Gly Gly His Leu Thr His Gly Ser Pro Val Asn Phe 
        115                 120                 125             

Ser Gly Ile Gln Tyr Asn Phe Val Glu Tyr Gly Val Asp Pro Glu Thr 
    130                 135                 140                 

His Val Ile Asp Tyr Asp Asp Val Arg Glu Lys Ala Arg Leu His Arg 
145                 150                 155                 160 

Pro Lys Leu Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Ile Ile Asp 
                165                 170                 175     

Phe Ala Lys Phe Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu Met 
            180                 185                 190         

Val Asp Met Ala His Ile Ala Gly Leu Val Ala Ala Gly Val His Pro 
        195                 200                 205             

Asn Pro Val Pro Tyr Ala His Phe Val Thr Thr Thr Thr His Lys Thr 
    210                 215                 220                 

Leu Arg Gly Pro Arg Gly Gly Met Ile Leu Cys Gln Glu Gln Phe Ala 
225                 230                 235                 240 

Lys Gln Ile Asp Lys Ala Ile Phe Pro Gly Ile Gln Gly Gly Pro Leu 
                245                 250                 255     

Met His Val Ile Ala Ala Lys Ala Val Ala Leu Gly Glu Ala Leu Gln 
            260                 265                 270         

Asp Asp Phe Lys Val Tyr Ala Lys Arg Val Val Glu Asn Ala Lys Arg 
        275                 280                 285             

Leu Ala Ala Ala Leu Gln Asn Glu Gly Phe Thr Leu Ile Ser Gly Gly 
    290                 295                 300                 

Thr Asp Asn His Leu Leu Leu Val Asp Leu Arg Pro Gln Gln Leu Thr 
305                 310                 315                 320 

Gly Lys Thr Ala Glu Lys Val Leu Asp Glu Val Gly Ile Thr Val Asn 
                325                 330                 335     

Lys Asn Thr Ile Pro Tyr Asp Pro Glu Ser Pro Phe Val Thr Ser Gly 
            340                 345                 350         

Ile Arg Ile Gly Thr Ala Ala Val Thr Thr Arg Gly Phe Gly Leu Glu 
        355                 360                 365             

Glu Met Asp Glu Ile Ala Ala Ile Ile Gly Leu Val Leu Lys Asn Val 
    370                 375                 380                 

Gly Ser Glu Gln Ala Leu Glu Glu Ala Arg Gln Arg Val Ala Ala Leu 
385                 390                 395                 400 

Thr Glu Lys Phe Pro Leu Tyr 
                405         

<210>   42
<211>   447
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   42
Met Cys Ala Pro Cys Ser Asn Arg Lys Met Asn Val Asn Arg Gly Val 
                5                   10                  15      

Leu Ser His Ala Ala Leu Asp Glu Arg Ser Cys Ala Gly Leu Thr Thr 
            20                  25                  30          

Leu Leu Gln Gln Val Asp Pro Asp Val Ala Ser Ala Met Gln Ala Glu 
        35                  40                  45              

Leu Arg Arg Gln Gln Arg Asn Ile Glu Leu Ile Ala Ser Glu Asn Phe 
    50                  55                  60                  

Val Ser Glu Ala Val Leu Glu Ala Leu Gly Ser Val Leu Thr Asn Lys 
65                  70                  75                  80  

Tyr Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr 
                85                  90                  95      

Val Asp Val Val Glu Arg Ile Ala Ile Asp Arg Val Lys Glu Leu Phe 
            100                 105                 110         

Gly Ala Glu Tyr Ala Asn Val Gln Pro His Ser Gly Ser Gln Ala Asn 
        115                 120                 125             

Met Thr Val Tyr Phe Ser Val Leu Lys Pro Gly Asp Thr Val Leu Gly 
    130                 135                 140                 

Met Asn Leu Ala His Gly Gly His Leu Thr His Gly Ser Pro Val Asn 
145                 150                 155                 160 

Phe Ser Gly Gln Leu Tyr Lys Phe Val Ser Tyr Gly Val His Pro Glu 
                165                 170                 175     

Thr His Leu Ile Asp Tyr Asp Glu Val Leu Lys Val Ala Lys Glu His 
            180                 185                 190         

Arg Pro Lys Met Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Val Ile 
        195                 200                 205             

Asp Phe Lys Arg Met Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu 
    210                 215                 220                 

Met Val Asp Met Ala His Ile Ala Gly Leu Ile Ala Ala Gly Leu His 
225                 230                 235                 240 

Pro Ser Pro Val Pro Tyr Ala His Phe Val Thr Ser Thr Thr His Lys 
                245                 250                 255     

Thr Leu Arg Gly Pro Arg Gly Gly Phe Ile Leu Cys Gln Lys Asp Val 
            260                 265                 270         

Ala Lys Ile Ile Asp Lys Thr Asn Phe Pro Gly Val Gln Gly Gly Pro 
        275                 280                 285             

Leu Met His Val Ile Ala Ala Lys Ala Val Ala Phe Gly Glu Ala Leu 
    290                 295                 300                 

Lys Pro Glu Phe Lys Ala Tyr Gln Glu Gln Ile Val Lys Asn Ala Lys 
305                 310                 315                 320 

Ala Leu Ala Glu Ala Leu Lys Gly Tyr Gly Phe Arg Leu Val Ser Gly 
                325                 330                 335     

Gly Thr Asp Asn His Leu Met Leu Ile Asp Val Arg Ser Ala Gly Leu 
            340                 345                 350         

Thr Gly Lys Glu Ala Glu Arg Arg Leu Asp Glu Ile Gly Ile Thr Val 
        355                 360                 365             

Asn Lys Asn Ala Ile Pro Phe Asp Pro Glu Ser Pro Met Val Thr Ser 
    370                 375                 380                 

Gly Ile Arg Val Gly Thr Pro Ala Ala Thr Ser Arg Gly Met Asp Glu 
385                 390                 395                 400 

Gly Ala Met Gln Glu Ile Ala Glu Ile Phe Lys Leu Val Leu Leu Gly 
                405                 410                 415     

Asp Phe Ser Asp Glu Val Lys Arg Glu Ala Arg Ala Arg Val Asp Ser 
            420                 425                 430         

Leu Thr Asp Arg Phe Pro Leu Tyr Pro Thr Leu Ser Tyr Val Glu 
        435                 440                 445         

<210>   43
<211>   447
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   43
Met Cys Ala Pro Cys Ser Asn Arg Arg Met Asn Val Asn Arg Gly Val 
                5                   10                  15      

Leu Ser His Ala Ala Leu Asp Glu Arg Ser Cys Ala Gly Leu Thr Thr 
            20                  25                  30          

Leu Leu Gln Gln Val Asp Pro Asp Val Ala Ser Ala Met Gln Ala Glu 
        35                  40                  45              

Leu Arg Arg Gln Gln Arg Asn Ile Glu Leu Ile Ala Ser Glu Asn Phe 
    50                  55                  60                  

Val Ser Glu Ala Val Leu Glu Ala Leu Gly Ser Val Leu Thr Asn Lys 
65                  70                  75                  80  

Tyr Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr 
                85                  90                  95      

Val Asp Val Val Glu Arg Ile Ala Ile Asp Arg Val Lys Glu Leu Phe 
            100                 105                 110         

Gly Ala Glu Tyr Ala Asn Val Gln Pro His Ser Gly Ser Gln Ala Asn 
        115                 120                 125             

Met Thr Val Tyr Phe Ser Val Leu Lys Pro Gly Asp Thr Val Leu Gly 
    130                 135                 140                 

Met Asn Leu Ala His Gly Gly His Leu Thr His Gly Ser Pro Val Asn 
145                 150                 155                 160 

Phe Ser Gly Gln Leu Tyr Lys Phe Val Ser Tyr Gly Val His Pro Glu 
                165                 170                 175     

Thr His Leu Ile Asp Tyr Asp Glu Val Leu Lys Val Ala Lys Glu His 
            180                 185                 190         

Arg Pro Lys Met Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Val Ile 
        195                 200                 205             

Asp Phe Lys Arg Met Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu 
    210                 215                 220                 

Met Val Asp Met Ala His Ile Ala Gly Leu Ile Ala Ala Gly Leu His 
225                 230                 235                 240 

Pro Ser Pro Val Pro Tyr Ala His Phe Val Thr Ser Thr Thr His Lys 
                245                 250                 255     

Thr Leu Arg Gly Pro Arg Gly Gly Phe Ile Leu Cys Gln Lys Asp Val 
            260                 265                 270         

Ala Lys Leu Ile Asp Lys Thr Asn Phe Pro Gly Val Gln Gly Gly Pro 
        275                 280                 285             

Leu Met His Val Ile Ala Ala Lys Ala Val Ala Phe Gly Glu Ala Leu 
    290                 295                 300                 

Lys Pro Glu Phe Lys Ala Tyr Gln Glu Gln Ile Val Lys Asn Ala Lys 
305                 310                 315                 320 

Ala Leu Ala Glu Ala Leu Lys Gly Tyr Gly Phe Arg Leu Val Ser Gly 
                325                 330                 335     

Gly Thr Asp Asn His Leu Met Leu Ile Asp Val Arg Ser Ala Gly Leu 
            340                 345                 350         

Thr Gly Lys Glu Ala Glu Arg Arg Leu Asp Glu Ile Gly Ile Thr Val 
        355                 360                 365             

Asn Lys Asn Ala Ile Pro Phe Asp Pro Glu Ser Pro Met Val Thr Ser 
    370                 375                 380                 

Gly Ile Arg Val Gly Thr Pro Ala Ala Thr Ser Arg Gly Met Asp Glu 
385                 390                 395                 400 

Gly Ala Met Gln Glu Ile Ala Glu Ile Phe Lys Leu Val Leu Leu Gly 
                405                 410                 415     

Asp Phe Ser Asp Glu Val Lys Arg Glu Ala Arg Ala Arg Val Asp Ser 
            420                 425                 430         

Leu Thr Asp Arg Phe Pro Leu Tyr Pro Thr Leu Ser Tyr Val Glu 
        435                 440                 445         

<210>   44
<211>   447
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   44
Met Cys Ala Pro Cys Ser Asn Arg Lys Met Asn Val Asn Arg Gly Val 
                5                   10                  15      

Leu Ser His Ala Ala Leu Asp Glu Arg Ser Cys Ala Gly Leu Thr Thr 
            20                  25                  30          

Leu Leu Gln Gln Val Asp Pro Asp Val Ala Ser Ala Met Gln Ala Glu 
        35                  40                  45              

Leu Arg Arg Gln Gln Arg Asn Ile Glu Leu Ile Ala Ser Glu Asn Phe 
    50                  55                  60                  

Val Ser Glu Ala Val Leu Glu Ala Leu Gly Ser Val Leu Thr Asn Lys 
65                  70                  75                  80  

Tyr Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr 
                85                  90                  95      

Val Asp Val Val Glu Arg Ile Ala Ile Asp Arg Val Lys Asp Leu Phe 
            100                 105                 110         

Gly Ala Glu Tyr Ala Asn Val Gln Pro His Ser Gly Ser Gln Ala Asn 
        115                 120                 125             

Met Thr Val Tyr Phe Ser Val Leu Lys Pro Gly Asp Thr Val Leu Gly 
    130                 135                 140                 

Met Asn Leu Ala His Gly Gly His Leu Thr His Gly Ser Pro Val Asn 
145                 150                 155                 160 

Phe Ser Gly Gln Leu Tyr Lys Phe Val Ser Tyr Gly Val His Pro Glu 
                165                 170                 175     

Thr His Leu Ile Asp Tyr Asp Glu Val Leu Lys Val Ala Lys Glu His 
            180                 185                 190         

Arg Pro Lys Met Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Val Ile 
        195                 200                 205             

Asp Phe Lys Arg Met Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu 
    210                 215                 220                 

Met Val Asp Met Ala His Ile Ala Gly Leu Ile Ala Ala Gly Leu His 
225                 230                 235                 240 

Pro Ser Pro Val Pro Tyr Ala His Phe Val Thr Ser Thr Thr His Lys 
                245                 250                 255     

Thr Leu Arg Gly Pro Arg Gly Gly Phe Ile Leu Cys Gln Lys Asp Val 
            260                 265                 270         

Ala Lys Leu Ile Asp Lys Thr Asn Phe Pro Gly Val Gln Gly Gly Pro 
        275                 280                 285             

Leu Met His Val Ile Ala Ala Lys Ala Val Ala Phe Gly Glu Ala Leu 
    290                 295                 300                 

Lys Pro Glu Phe Lys Ala Tyr Gln Glu Gln Ile Val Lys Asn Ala Lys 
305                 310                 315                 320 

Ala Leu Ala Glu Ala Leu Lys Gly Tyr Gly Phe Arg Leu Val Ser Gly 
                325                 330                 335     

Gly Thr Asp Asn His Leu Met Leu Ile Asp Val Arg Ser Ala Gly Leu 
            340                 345                 350         

Thr Gly Lys Glu Ala Glu Arg Arg Leu Asp Glu Ile Gly Ile Thr Val 
        355                 360                 365             

Asn Lys Asn Ala Ile Pro Phe Asp Pro Glu Ser Pro Met Val Thr Ser 
    370                 375                 380                 

Gly Ile Arg Val Gly Thr Pro Ala Ala Thr Ser Arg Gly Met Asp Glu 
385                 390                 395                 400 

Gly Ala Met Gln Glu Ile Ala Glu Ile Phe Lys Leu Val Leu Leu Gly 
                405                 410                 415     

Asp Phe Ser Asp Glu Val Lys Arg Glu Ala Arg Ala Arg Val Asp Ser 
            420                 425                 430         

Leu Thr Asp Arg Phe Pro Leu Tyr Pro Thr Leu Ser Tyr Val Glu 
        435                 440                 445         

<210>   45
<211>   447
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   45
Met Cys Ala Pro Cys Ser Asn Arg Lys Met Gln Val Asn Arg Gly Val 
                5                   10                  15      

Leu Ser His Ala Ala Leu Asp Glu Arg Ser Cys Ala Gly Leu Thr Thr 
            20                  25                  30          

Leu Leu Gln Gln Val Asp Pro Asp Val Ala Ser Ala Met Gln Ala Glu 
        35                  40                  45              

Leu Arg Arg Gln Gln Arg Asn Ile Glu Leu Ile Ala Ser Glu Asn Phe 
    50                  55                  60                  

Val Ser Glu Ala Val Leu Glu Ala Leu Gly Ser Val Leu Thr Asn Lys 
65                  70                  75                  80  

Tyr Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr 
                85                  90                  95      

Val Asp Val Val Glu Arg Ile Ala Ile Asp Arg Val Lys Glu Leu Phe 
            100                 105                 110         

Gly Ala Glu Tyr Ala Asn Val Gln Pro His Ser Gly Ser Gln Ala Asn 
        115                 120                 125             

Met Thr Val Tyr Phe Ser Val Leu Lys Pro Gly Asp Thr Val Leu Gly 
    130                 135                 140                 

Met Asn Leu Ala His Gly Gly His Leu Thr His Gly Ser Pro Val Asn 
145                 150                 155                 160 

Phe Ser Gly Gln Leu Tyr Lys Phe Val Ser Tyr Gly Val His Pro Glu 
                165                 170                 175     

Thr His Leu Ile Asp Tyr Asp Glu Val Leu Lys Val Ala Lys Glu His 
            180                 185                 190         

Arg Pro Lys Met Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Val Ile 
        195                 200                 205             

Asp Phe Lys Arg Met Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu 
    210                 215                 220                 

Met Val Asp Met Ala His Ile Ala Gly Leu Ile Ala Ala Gly Leu His 
225                 230                 235                 240 

Pro Ser Pro Val Pro Tyr Ala His Phe Val Thr Ser Thr Thr His Lys 
                245                 250                 255     

Thr Leu Arg Gly Pro Arg Gly Gly Phe Ile Leu Cys Gln Lys Asp Val 
            260                 265                 270         

Ala Lys Leu Ile Asp Lys Thr Asn Phe Pro Gly Val Gln Gly Gly Pro 
        275                 280                 285             

Leu Met His Val Ile Ala Ala Lys Ala Val Ala Phe Gly Glu Ala Leu 
    290                 295                 300                 

Lys Pro Glu Phe Lys Ala Tyr Gln Glu Gln Ile Val Lys Asn Ala Lys 
305                 310                 315                 320 

Ala Leu Ala Glu Ala Leu Lys Gly Tyr Gly Phe Arg Leu Val Ser Gly 
                325                 330                 335     

Gly Thr Asp Asn His Leu Met Leu Ile Asp Val Arg Ser Ala Gly Leu 
            340                 345                 350         

Thr Gly Lys Glu Ala Glu Arg Arg Leu Asp Glu Ile Gly Ile Thr Val 
        355                 360                 365             

Asn Lys Asn Ala Ile Pro Phe Asp Pro Glu Ser Pro Met Val Thr Ser 
    370                 375                 380                 

Gly Ile Arg Val Gly Thr Pro Ala Ala Thr Ser Arg Gly Met Asp Glu 
385                 390                 395                 400 

Gly Ala Met Gln Glu Ile Ala Glu Ile Phe Lys Leu Val Leu Leu Gly 
                405                 410                 415     

Asp Phe Ser Asp Glu Val Lys Arg Glu Ala Arg Ala Arg Val Asp Ser 
            420                 425                 430         

Leu Thr Asp Arg Phe Pro Leu Tyr Pro Thr Leu Ser Tyr Val Glu 
        435                 440                 445         

<210>   46
<211>   447
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   46
Met Cys Ala Pro Cys Ser Asn Arg Lys Met Asn Val Asn Arg Gly Val 
                5                   10                  15      

Leu Ser His Ala Ala Leu Glu Glu Arg Ser Cys Ala Gly Leu Thr Thr 
            20                  25                  30          

Leu Leu Gln Gln Val Asp Pro Asp Val Ala Ser Ala Met Gln Ala Glu 
        35                  40                  45              

Leu Arg Arg Gln Gln Arg Asn Ile Glu Leu Ile Ala Ser Glu Asn Phe 
    50                  55                  60                  

Val Ser Glu Ala Val Leu Glu Ala Leu Gly Ser Val Leu Thr Asn Lys 
65                  70                  75                  80  

Tyr Ala Glu Gly Tyr Pro Gly Arg Arg Tyr Tyr Gly Gly Cys Glu Tyr 
                85                  90                  95      

Val Asp Val Val Glu Arg Ile Ala Ile Asp Arg Val Lys Glu Leu Phe 
            100                 105                 110         

Gly Ala Glu Tyr Ala Asn Val Gln Pro His Ser Gly Ser Gln Ala Asn 
        115                 120                 125             

Met Thr Val Tyr Phe Ser Val Leu Lys Pro Gly Asp Thr Val Leu Gly 
    130                 135                 140                 

Met Asn Leu Ala His Gly Gly His Leu Thr His Gly Ser Pro Val Asn 
145                 150                 155                 160 

Phe Ser Gly Gln Leu Tyr Lys Phe Val Ser Tyr Gly Val His Pro Glu 
                165                 170                 175     

Thr His Leu Ile Asp Tyr Asp Glu Val Leu Lys Val Ala Lys Glu His 
            180                 185                 190         

Arg Pro Lys Met Ile Val Ala Gly Ala Ser Ala Tyr Pro Arg Val Ile 
        195                 200                 205             

Asp Phe Lys Arg Met Arg Glu Ile Ala Asp Glu Val Gly Ala Tyr Leu 
    210                 215                 220                 

Met Val Asp Met Ala His Ile Ala Gly Leu Ile Ala Ala Gly Leu His 
225                 230                 235                 240 

Pro Ser Pro Val Pro Tyr Ala His Phe Val Thr Ser Thr Thr His Lys 
                245                 250                 255     

Thr Leu Arg Gly Pro Arg Gly Gly Phe Ile Leu Cys Gln Lys Asp Val 
            260                 265                 270         

Ala Lys Leu Ile Asp Lys Thr Asn Phe Pro Gly Val Gln Gly Gly Pro 
        275                 280                 285             

Leu Met His Val Ile Ala Ala Lys Ala Val Ala Phe Gly Glu Ala Leu 
    290                 295                 300                 

Lys Pro Glu Phe Lys Ala Tyr Gln Glu Gln Ile Val Lys Asn Ala Lys 
305                 310                 315                 320 

Ala Leu Ala Glu Ala Leu Lys Gly Tyr Gly Phe Arg Leu Val Ser Gly 
                325                 330                 335     

Gly Thr Asp Asn His Leu Met Leu Ile Asp Val Arg Ser Ala Gly Leu 
            340                 345                 350         

Thr Gly Lys Glu Ala Glu Arg Arg Leu Asp Glu Ile Gly Ile Thr Val 
        355                 360                 365             

Asn Lys Asn Ala Ile Pro Phe Asp Pro Glu Ser Pro Met Val Thr Ser 
    370                 375                 380                 

Gly Ile Arg Val Gly Thr Pro Ala Ala Thr Ser Arg Gly Met Asp Glu 
385                 390                 395                 400 

Gly Ala Met Gln Glu Ile Ala Glu Ile Phe Lys Leu Val Leu Leu Gly 
                405                 410                 415     

Asp Phe Ser Asp Glu Val Lys Arg Glu Ala Arg Ala Arg Val Asp Ser 
            420                 425                 430         

Leu Thr Asp Arg Phe Pro Leu Tyr Pro Thr Leu Ser Tyr Val Glu 
        435                 440                 445         

<210>   47
<211>   1344
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   47
ttgtgcgccc cgtgttcgaa ccgtaagatg aatgtgaatc gcggcgtcct ctcgcatgcg       60

gcgctggatg aaaggagttg cgcaggattg accacccttc tgcagcaggt tgacccggat      120

gtcgcgtctg cgatgcaggc cgagctccgt cggcagcagc ggaacatcga actcatcgct      180

tcagaaaact ttgtcagcga ggccgttctc gaggcccttg gatccgtcct gacgaacaaa      240

tacgccgaag gctacccagg ccggcgctat tacggcggct gcgagtacgt cgacgtggtc      300

gagcgcattg ccatcgatcg cgtcaaggag ctgttcggcg ccgagtacgc gaacgtccag      360

ccgcacagtg gttcgcaggc gaacatgacg gtctacttca gcgtcctcaa gccgggcgac      420

acggtgctcg gcatgaatct ggcgcacggc ggccacttga cgcatgggag ccccgtgaac      480

ttctccgggc agctttacaa gttcgtctcg tacggcgtcc acccggagac ccatctcatc      540

gattacgacg aggtgctcaa ggtcgcgaag gaacatcggc cgaagatgat cgtcgccggc      600

gcgagcgcgt acccgcgcgt catcgacttc aaacgcatgc gggagattgc ggacgaggtc      660

ggcgcgtatc tgatggtgga catggcgcac attgcgggcc tcattgccgc ggggcttcac      720

ccgtcccccg tgccgtacgc gcacttcgtg acgtccacga cgcacaagac gcttcggggt      780

ccgcgcggcg ggttcatcct ctgtcagaag gacgtcgcca agattatcga caagacgaat      840

ttccccggcg tccagggcgg tcccctcatg cacgtgattg cagcgaaggc cgtcgccttc      900

ggggaagctt tgaaacccga attcaaggcg taccaggagc agattgtgaa gaacgcgaag      960

gcgctcgccg aagcgctcaa agggtacggg ttccgcctcg tgtccggcgg caccgacaac     1020

cacctgatgc tcatcgacgt ccgcagcgcg gggctgaccg gcaaagaagc cgagcggagg     1080

ctggacgaga tcggcatcac ggtcaacaag aacgccatcc cattcgatcc ggagagcccg     1140

atggtgacga gcggcatccg cgtcggcacg cctgccgcga cttcgcgcgg catggacgag     1200

ggcgcgatgc aggagattgc cgagatcttc aagctcgtgc tcctcggcga cttcagcgac     1260

gaggtgaagc gcgaggctcg cgctcgcgtc gacagcttga cggaccggtt tccgctctat     1320

ccgactttgt cctacgtcga atga                                            1344


<210>   48
<211>   1344
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   48
ttgtgcgccc cgtgttcgaa ccgtcgtatg aatgtgaatc gcggcgtcct ctcgcatgcg       60

gcgctggatg aaaggagttg cgcaggattg accacccttc tgcagcaggt tgacccggat      120

gtcgcgtctg cgatgcaggc cgagctccgt cggcagcagc ggaacatcga actcatcgct      180

tcagaaaact ttgtcagcga ggccgttctc gaggcccttg gatccgtcct gacgaacaaa      240

tacgccgaag gctacccagg ccggcgctat tacggcggct gcgagtacgt cgacgtggtc      300

gagcgcattg ccatcgatcg cgtcaaggag ctgttcggcg ccgagtacgc gaacgtccag      360

ccgcacagtg gttcgcaggc gaacatgacg gtctacttca gcgtcctcaa gccgggcgac      420

acggtgctcg gcatgaatct ggcgcacggc ggccacttga cgcatgggag ccccgtgaac      480

ttctccgggc agctttacaa gttcgtctcg tacggcgtcc acccggagac ccatctcatc      540

gattacgacg aggtgctcaa ggtcgcgaag gaacatcggc cgaagatgat cgtcgccggc      600

gcgagcgcgt acccgcgcgt catcgacttc aaacgcatgc gggagattgc ggacgaggtc      660

ggcgcgtatc tgatggtgga catggcgcac attgcgggcc tcattgccgc ggggcttcac      720

ccgtcccccg tgccgtacgc gcacttcgtg acgtccacga cgcacaagac gcttcggggt      780

ccgcgcggcg ggttcatcct ctgtcagaag gacgtcgcca agctcatcga caagacgaat      840

ttccccggcg tccagggcgg tcccctcatg cacgtgattg cagcgaaggc cgtcgccttc      900

ggggaagctt tgaaacccga attcaaggcg taccaggagc agattgtgaa gaacgcgaag      960

gcgctcgccg aagcgctcaa agggtacggg ttccgcctcg tgtccggcgg caccgacaac     1020

cacctgatgc tcatcgacgt ccgcagcgcg gggctgaccg gcaaagaagc cgagcggagg     1080

ctggacgaga tcggcatcac ggtcaacaag aacgccatcc cattcgatcc ggagagcccg     1140

atggtgacga gcggcatccg cgtcggcacg cctgccgcga cttcgcgcgg catggacgag     1200

ggcgcgatgc aggagattgc cgagatcttc aagctcgtgc tcctcggcga cttcagcgac     1260

gaggtgaagc gcgaggctcg cgctcgcgtc gacagcttga cggaccggtt tccgctctat     1320

ccgactttgt cctacgtcga atga                                            1344


<210>   49
<211>   1344
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   49
ttgtgcgccc cgtgttcgaa ccgtaagatg aatgtgaatc gcggcgtcct ctcgcatgcg       60

gcgctggatg aaaggagttg cgcaggattg accacccttc tgcagcaggt tgacccggat      120

gtcgcgtctg cgatgcaggc cgagctccgt cggcagcagc ggaacatcga actcatcgct      180

tcagaaaact ttgtcagcga ggccgttctc gaggcccttg gatccgtcct gacgaacaaa      240

tacgccgaag gctacccagg ccggcgctat tacggcggct gcgagtacgt cgacgtggtc      300

gagcgcattg ccatcgatcg cgtcaaggat ctgttcggcg ccgagtacgc gaacgtccag      360

ccgcacagtg gttcgcaggc gaacatgacg gtctacttca gcgtcctcaa gccgggcgac      420

acggtgctcg gcatgaatct ggcgcacggc ggccacttga cgcatgggag ccccgtgaac      480

ttctccgggc agctttacaa gttcgtctcg tacggcgtcc acccggagac ccatctcatc      540

gattacgacg aggtgctcaa ggtcgcgaag gaacatcggc cgaagatgat cgtcgccggc      600

gcgagcgcgt acccgcgcgt catcgacttc aaacgcatgc gggagattgc ggacgaggtc      660

ggcgcgtatc tgatggtgga catggcgcac attgcgggcc tcattgccgc ggggcttcac      720

ccgtcccccg tgccgtacgc gcacttcgtg acgtccacga cgcacaagac gcttcggggt      780

ccgcgcggcg ggttcatcct ctgtcagaag gacgtcgcca agctcatcga caagacgaat      840

ttccccggcg tccagggcgg tcccctcatg cacgtgattg cagcgaaggc cgtcgccttc      900

ggggaagctt tgaaacccga attcaaggcg taccaggagc agattgtgaa gaacgcgaag      960

gcgctcgccg aagcgctcaa agggtacggg ttccgcctcg tgtccggcgg caccgacaac     1020

cacctgatgc tcatcgacgt ccgcagcgcg gggctgaccg gcaaagaagc cgagcggagg     1080

ctggacgaga tcggcatcac ggtcaacaag aacgccatcc cattcgatcc ggagagcccg     1140

atggtgacga gcggcatccg cgtcggcacg cctgccgcga cttcgcgcgg catggacgag     1200

ggcgcgatgc aggagattgc cgagatcttc aagctcgtgc tcctcggcga cttcagcgac     1260

gaggtgaagc gcgaggctcg cgctcgcgtc gacagcttga cggaccggtt tccgctctat     1320

ccgactttgt cctacgtcga atga                                            1344


<210>   50
<211>   1344
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   50
ttgtgcgccc cgtgttcgaa ccgtaagatg caagtgaatc gcggcgtcct ctcgcatgcg       60

gcgctggatg aaaggagttg cgcaggattg accacccttc tgcagcaggt tgacccggat      120

gtcgcgtctg cgatgcaggc cgagctccgt cggcagcagc ggaacatcga actcatcgct      180

tcagaaaact ttgtcagcga ggccgttctc gaggcccttg gatccgtcct gacgaacaaa      240

tacgccgaag gctacccagg ccggcgctat tacggcggct gcgagtacgt cgacgtggtc      300

gagcgcattg ccatcgatcg cgtcaaggag ctgttcggcg ccgagtacgc gaacgtccag      360

ccgcacagtg gttcgcaggc gaacatgacg gtctacttca gcgtcctcaa gccgggcgac      420

acggtgctcg gcatgaatct ggcgcacggc ggccacttga cgcatgggag ccccgtgaac      480

ttctccgggc agctttacaa gttcgtctcg tacggcgtcc acccggagac ccatctcatc      540

gattacgacg aggtgctcaa ggtcgcgaag gaacatcggc cgaagatgat cgtcgccggc      600

gcgagcgcgt acccgcgcgt catcgacttc aaacgcatgc gggagattgc ggacgaggtc      660

ggcgcgtatc tgatggtgga catggcgcac attgcgggcc tcattgccgc ggggcttcac      720

ccgtcccccg tgccgtacgc gcacttcgtg acgtccacga cgcacaagac gcttcggggt      780

ccgcgcggcg ggttcatcct ctgtcagaag gacgtcgcca agctcatcga caagacgaat      840

ttccccggcg tccagggcgg tcccctcatg cacgtgattg cagcgaaggc cgtcgccttc      900

ggggaagctt tgaaacccga attcaaggcg taccaggagc agattgtgaa gaacgcgaag      960

gcgctcgccg aagcgctcaa agggtacggg ttccgcctcg tgtccggcgg caccgacaac     1020

cacctgatgc tcatcgacgt ccgcagcgcg gggctgaccg gcaaagaagc cgagcggagg     1080

ctggacgaga tcggcatcac ggtcaacaag aacgccatcc cattcgatcc ggagagcccg     1140

atggtgacga gcggcatccg cgtcggcacg cctgccgcga cttcgcgcgg catggacgag     1200

ggcgcgatgc aggagattgc cgagatcttc aagctcgtgc tcctcggcga cttcagcgac     1260

gaggtgaagc gcgaggctcg cgctcgcgtc gacagcttga cggaccggtt tccgctctat     1320

ccgactttgt cctacgtcga atga                                            1344


<210>   51
<211>   1344
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   51
ttgtgcgccc cgtgttcgaa ccgtaagatg aatgtgaatc gcggcgtcct ctcgcatgcg       60

gcgctggaag aaaggagttg cgcaggattg accacccttc tgcagcaggt tgacccggat      120

gtcgcgtctg cgatgcaggc cgagctccgt cggcagcagc ggaacatcga actcatcgct      180

tcagaaaact ttgtcagcga ggccgttctc gaggcccttg gatccgtcct gacgaacaaa      240

tacgccgaag gctacccagg ccggcgctat tacggcggct gcgagtacgt cgacgtggtc      300

gagcgcattg ccatcgatcg cgtcaaggag ctgttcggcg ccgagtacgc gaacgtccag      360

ccgcacagtg gttcgcaggc gaacatgacg gtctacttca gcgtcctcaa gccgggcgac      420

acggtgctcg gcatgaatct ggcgcacggc ggccacttga cgcatgggag ccccgtgaac      480

ttctccgggc agctttacaa gttcgtctcg tacggcgtcc acccggagac ccatctcatc      540

gattacgacg aggtgctcaa ggtcgcgaag gaacatcggc cgaagatgat cgtcgccggc      600

gcgagcgcgt acccgcgcgt catcgacttc aaacgcatgc gggagattgc ggacgaggtc      660

ggcgcgtatc tgatggtgga catggcgcac attgcgggcc tcattgccgc ggggcttcac      720

ccgtcccccg tgccgtacgc gcacttcgtg acgtccacga cgcacaagac gcttcggggt      780

ccgcgcggcg ggttcatcct ctgtcagaag gacgtcgcca agctcatcga caagacgaat      840

ttccccggcg tccagggcgg tcccctcatg cacgtgattg cagcgaaggc cgtcgccttc      900

ggggaagctt tgaaacccga attcaaggcg taccaggagc agattgtgaa gaacgcgaag      960

gcgctcgccg aagcgctcaa agggtacggg ttccgcctcg tgtccggcgg caccgacaac     1020

cacctgatgc tcatcgacgt ccgcagcgcg gggctgaccg gcaaagaagc cgagcggagg     1080

ctggacgaga tcggcatcac ggtcaacaag aacgccatcc cattcgatcc ggagagcccg     1140

atggtgacga gcggcatccg cgtcggcacg cctgccgcga cttcgcgcgg catggacgag     1200

ggcgcgatgc aggagattgc cgagatcttc aagctcgtgc tcctcggcga cttcagcgac     1260

gaggtgaagc gcgaggctcg cgctcgcgtc gacagcttga cggaccggtt tccgctctat     1320

ccgactttgt cctacgtcga atga                                            1344


<210>   52
<211>   261
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   52
Met Arg Asn Leu Thr Glu Thr Phe Thr Thr Tyr Arg Val Glu Asp His 
                5                   10                  15      

Val Ala Val Leu Thr Leu Asn Arg Pro Gln Ala Leu Asn Ala Leu Ser 
            20                  25                  30          

Arg Glu Val Leu Ser Glu Ile Gly Ala His Leu Ala Met Leu Asp Leu 
        35                  40                  45              

Lys Asp Val Arg Val Leu Val Ile Arg Gly Glu Gly Arg Val Phe Cys 
    50                  55                  60                  

Ala Gly Ala Asp Ile Gly Gln Met Gln His Met Ser Ala Val Glu Ala 
65                  70                  75                  80  

Glu Ser Met Ala Arg Leu Gly Gln Arg Val Phe Gln Ala Ile Glu Gln 
                85                  90                  95      

Leu Pro Ile Pro Val Ile Ala Leu Ile His Gly Gly Ala Phe Gly Gly 
            100                 105                 110         

Gly Leu Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Ala Ala Ala Gly 
        115                 120                 125             

Ala Val Val Gly Leu Pro Glu Val Thr Leu Gly Val Asn Pro Ser Phe 
    130                 135                 140                 

Gly Gly Thr Tyr Arg Leu Pro Arg Ala Ile Gly Phe Ala Arg Ala Leu 
145                 150                 155                 160 

Ser Met Met Leu Leu Gly Glu Arg Ile Pro Val Glu Lys Ala Leu Glu 
                165                 170                 175     

Tyr Gly Leu Val Asn Glu Val Val Ala Pro Asp Glu Leu Glu Ala Arg 
            180                 185                 190         

Gly Met Asp Leu Ala Arg Lys Leu Ala Ser Gln Ser Ser Ala Ala Met 
        195                 200                 205             

Ala Ala Ile Lys Arg Ser Ala His His Gly Phe Gly Gln Asp Pro Ala 
    210                 215                 220                 

Arg Ala Gln Ala Tyr Glu Ala Ala Gln Phe Gly Leu Cys Phe Ala Ser 
225                 230                 235                 240 

Gly Asp Ala His Glu Gly Met Ala Ala Phe Lys Glu Lys Arg Gln Ala 
                245                 250                 255     

Arg Phe His Glu Asp 
            260     

<210>   53
<211>   786
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   53
gtgaggaatt tgacagagac gttcaccacg taccgcgtgg aggatcatgt ggcggttttg       60

acgctcaatc gtccgcaggc tttgaacgcg ctttctcgag aagtgctgtc ggaaatcggt      120

gcgcatcttg cgatgttgga tctcaaggac gtccgcgttc tcgtcatccg cggcgagggc      180

cgggtgttct gcgcgggcgc ggacatcggc cagatgcagc acatgagcgc cgtggaggcc      240

gagagcatgg cgcgccttgg gcagcgcgtg ttccaggcca tcgaacagct gcccattccg      300

gtgattgcgc tgattcacgg cggggcgttt ggcggggggc ttgaactcgc gctcgcgtgc      360

gattttcgga ttgcggccgc aggcgccgtc gtcgggctgc ccgaggtgac gctgggggtc      420

aacccgagtt tcggcgggac gtaccggctc ccgcgcgcca tcgggttcgc gcgcgcgctc      480

tcgatgatgc ttctggggga gcggatcccg gtcgagaagg ccctggagta cgggctcgtg      540

aacgaggtgg tggcgcctga cgagctcgag gcgaggggca tggatctcgc gcgaaaactc      600

gcgagccagt cgagcgccgc gatggcggcc atcaagcggt cggcccacca cgggtttggg      660

caggatccag ctcgcgcgca ggcgtatgag gcggcgcagt tcggcctgtg ctttgcttct      720

ggggacgcgc acgagggcat ggcggccttc aaggagaagc gccaggcgag gtttcacgag      780

gactga                                                                 786


<210>   54
<211>   245
<212>   PRT
<213>   Porphyromonas gingivalis W83

<400>   54
Lys Asp Gly Ile Thr Thr Leu Thr Ile Asn Lys Pro Glu Thr Leu Asn 
                5                   10                  15      

Ala Leu Ser Ser Glu Val Leu Ser Glu Leu Lys Ser Ala Ile Ala Val 
            20                  25                  30          

Ile Ala Thr Glu Lys Pro Arg Val Leu Ile Ile Thr Gly Ser Gly Lys 
        35                  40                  45              

Ala Phe Val Ala Gly Ala Asp Ile Ala Glu Met Gln His Leu Ser Ala 
    50                  55                  60                  

Ala Glu Gly Lys Ala Phe Gly Gly Leu Gly Ala Glu Val Phe Arg Arg 
65                  70                  75                  80  

Ile Glu Glu Leu Pro Phe Pro Val Ile Ala Ala Ile Asn Gly Phe Ala 
                85                  90                  95      

Leu Gly Gly Gly Cys Glu Leu Ala Met Ala Cys Asp Ile Arg Ile Ala 
            100                 105                 110         

Ser Ala Lys Ala Lys Phe Gly Gln Pro Glu Val Gly Leu Gly Ile Thr 
        115                 120                 125             

Pro Gly Phe Ser Gly Thr Gln Arg Leu Pro Arg Leu Val Ala Pro Gly 
    130                 135                 140                 

Ile Ala Lys Glu Leu Ile Tyr Thr Gly Arg Ile Ile Asp Ala Glu Glu 
145                 150                 155                 160 

Ala Leu Arg Ile Gly Leu Val Asn Arg Val Thr Thr Pro Glu Glu Leu 
                165                 170                 175     

Leu Pro Ala Thr Met Glu Thr Ala Gln Leu Ile Ala Ser Arg Ser Ala 
            180                 185                 190         

Ser Ala Val Ser Ala Ser Lys Glu Ala Ile Asn Arg Gly Thr Glu Met 
        195                 200                 205             

His Ile Ala Glu Gly Ile Ala Leu Glu Gln Asn Leu Phe Gly Leu Cys 
    210                 215                 220                 

Phe Ala Thr Ala Asp Gln Lys Glu Gly Met Ala Ala Phe Leu Glu Lys 
225                 230                 235                 240 

Arg Lys Pro Ala Phe 
                245 

<210>   55
<211>   250
<212>   PRT
<213>   Thermosinus carboxydivorans Nor1

<400>   55
Tyr Glu Phe Asp Gly Gly Ile Gly Ile Ile Thr Ile Asn Arg Pro Lys 
                5                   10                  15      

Ala Leu Asn Ala Leu Asn Gly Ala Thr Met Arg Glu Leu Asn Glu Leu 
            20                  25                  30          

Leu Asp Val Ile Ala Gln Asp Pro Ser Val Lys Val Val Ile Ile Thr 
        35                  40                  45              

Gly Ser Gly Glu Lys Ala Phe Val Ala Gly Ala Asp Ile Thr Glu Met 
    50                  55                  60                  

Gln Ser Met Ser Ala Ile Glu Gly Arg Asn Trp Gly Lys Leu Gly Gln 
65                  70                  75                  80  

Ala Val Phe Asp Lys Leu Glu Asn Leu Pro Gln Pro Val Ile Ala Ala 
                85                  90                  95      

Val Asn Gly Phe Ala Leu Gly Gly Gly Cys Glu Leu Ala Met Ala Cys 
            100                 105                 110         

Asp Ile Arg Ile Ala Ser Asp Lys Ala Lys Phe Gly Gln Pro Glu Val 
        115                 120                 125             

Thr Leu Gly Ile Thr Pro Gly Phe Ala Gly Thr Gln Arg Leu Pro Arg 
    130                 135                 140                 

Leu Val Gly Lys Gly Arg Ala Lys Glu Leu Leu Phe Thr Gly Asp Met 
145                 150                 155                 160 

Ile Asp Ala Ala Glu Ala Tyr Arg Ile Gly Leu Val Asn Lys Val Val 
                165                 170                 175     

Pro Pro Glu Glu Leu Met Ala Ala Ala Lys Ala Met Ala Gln Lys Ile 
            180                 185                 190         

Met Ser Arg Ala Pro Met Ala Val Gln Leu Cys Lys Ala Ala Val Asn 
        195                 200                 205             

Glu Gly Met Asp Met Asp Leu Gln Ser Ala Val Ala Tyr Glu Ala Glu 
    210                 215                 220                 

Val Phe Gly Leu Cys Phe Ala Thr Ala Asp Gln Lys Glu Gly Met Ala 
225                 230                 235                 240 

Ala Phe Val Glu Lys Arg Lys Ala Asn Phe 
                245                 250 

<210>   56
<211>   250
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   56
Phe Glu Lys Lys Asp Gln Val Gly Ile Ile Thr Ile Asn Arg Pro Gln 
                5                   10                  15      

Val Leu Asn Ala Leu Asn Ser Glu Val Leu Glu Glu Leu Asp Ser Leu 
            20                  25                  30          

Leu Asp Lys Ile Ala Glu Asp Glu Ser Ile Thr Val Val Ile Leu Thr 
        35                  40                  45              

Gly Ala Gly Glu Lys Ser Phe Val Ala Gly Ala Asp Ile Ser Gln Met 
    50                  55                  60                  

Arg Asn Phe Thr Pro Arg Gln Ala Arg Tyr Phe Ala Lys Leu Gly Gln 
65                  70                  75                  80  

Lys Val Leu Ser Lys Leu Glu Arg Ile Pro Gln Pro Val Ile Ala Ala 
                85                  90                  95      

Val Asn Gly Phe Ala Leu Gly Gly Gly Cys Glu Ile Ala Met Ala Cys 
            100                 105                 110         

Asp Phe Arg Ile Ala Ser Thr Lys Ala Lys Phe Gly Gln Pro Glu Val 
        115                 120                 125             

Gly Leu Gly Val Thr Ala Gly Phe Gly Gly Thr Gln Arg Leu Pro Arg 
    130                 135                 140                 

Leu Val Gly Lys Gly Met Ala Ala Glu Leu Leu Tyr Thr Gly Glu Met 
145                 150                 155                 160 

Ile Asp Ala Gln Glu Ala Leu Arg Ile Gly Leu Val Asn Arg Val Val 
                165                 170                 175     

Glu Pro Glu Glu Leu Met Pro Thr Ala Leu Glu Ile Ala Gln Lys Ile 
            180                 185                 190         

Ala Ala Lys Ala Lys Leu Ala Val Phe Tyr Ser Lys Ala Ala Leu Asn 
        195                 200                 205             

Glu Gly Leu Asn Met Asp Leu Glu Arg Ala Leu Ala Tyr Glu Ala Glu 
    210                 215                 220                 

Met Phe Ala Leu Cys Phe Thr Thr Ser Asp Gln Lys Glu Gly Met Asp 
225                 230                 235                 240 

Ala Phe Leu Asn Lys Arg Lys Pro Glu Phe 
                245                 250 

<210>   57
<211>   247
<212>   PRT
<213>   Syntrophomonas wolfei subsp. wolfei str. Goettingen

<400>   57
Glu Glu Lys Leu Ala Val Leu Tyr Ile Asn Arg Pro Lys Ala Met Asn 
                5                   10                  15      

Ala Leu Asn Lys Asp Thr Leu Leu Glu Ile Lys Asp Ala Val Thr Ala 
            20                  25                  30          

Val Asn Asp Asp Pro Ala Val Glu Leu Leu Ile Ile Thr Gly Ser Gly 
        35                  40                  45              

Asp Lys Ser Phe Val Ala Gly Ala Asp Ile Ala Phe Met Gln Asn Leu 
    50                  55                  60                  

Ser Ala Met Glu Ala Arg Glu Phe Gly Ala Leu Gly Gln Lys Val Phe 
65                  70                  75                  80  

Arg Leu Ile Glu Ala Met Glu Lys Pro Val Ile Ala Ala Val Asn Gly 
                85                  90                  95      

Phe Ala Leu Gly Gly Gly Cys Glu Leu Ala Met Cys Cys Asp Phe Arg 
            100                 105                 110         

Ile Ala Ala Ser Asn Ala Lys Phe Gly Gln Pro Glu Val Gly Leu Gly 
        115                 120                 125             

Ile Thr Pro Gly Phe Gly Gly Thr Gln Arg Leu Pro Arg Leu Val Gly 
    130                 135                 140                 

Pro Gly Met Ala Lys Gln Leu Leu Tyr Thr Ala Asp Val Ile Asn Ala 
145                 150                 155                 160 

Asp Glu Ala Phe Arg Ile Gly Leu Val Asn Lys Val Val Gln Pro Glu 
                165                 170                 175     

Glu Leu Leu Pro Glu Val Lys Lys Ile Ala Gly Arg Ile Leu Ser Lys 
            180                 185                 190         

Gly Gln Leu Ala Val Arg Leu Ser Lys Ala Ala Ala Asn Glu Gly Met 
        195                 200                 205             

Gln Thr Asp Ile Asp Arg Ala Met Ser Ile Glu Ala Asp Ala Phe Gly 
    210                 215                 220                 

Leu Cys Phe Ala Thr Gln Asp Gln Lys Glu Gly Met Thr Ala Phe Leu 
225                 230                 235                 240 

Glu Lys Arg Lys Ala Asn Phe 
                245         

<210>   58
<211>   248
<212>   PRT
<213>   Geobacter metallireducens GS-15

<400>   58
Arg His Asp Asp Ala Ile Ala Val Val Ser Leu Ala Arg Pro Glu Ser 
                5                   10                  15      

Arg Asn Val Leu Ser Arg Asp Leu Val Leu Gly Leu Leu Ser Thr Phe 
            20                  25                  30          

Thr Ser Leu Lys Asp Asp Gly Arg Val Lys Gly Ile Val Val Thr Gly 
        35                  40                  45              

Glu Gly Lys Ser Phe Cys Ala Gly Ala Asp Ile Ser Glu Met Ala Arg 
    50                  55                  60                  

Met Ser Pro Ala Glu Ala Ser Ser Phe Ala Glu Leu Gly Gln Arg Leu 
65                  70                  75                  80  

Met Phe Ala Val Glu Arg Val Gly Lys Pro Val Val Ala Ala Val Asn 
                85                  90                  95      

Gly His Ala Phe Gly Gly Gly Leu Glu Leu Ala Leu Ala Cys Asp Phe 
            100                 105                 110         

Ile Val Ala Ala Glu Ser Ala Val Phe Ala Ala Pro Glu Val Leu Leu 
        115                 120                 125             

Gly Val Met Pro Gly Phe Gly Gly Thr Gln Arg Leu Pro Arg Leu Ile 
    130                 135                 140                 

Gly Lys Ser Arg Ala Lys Glu Met Ile Phe Thr Gly Glu Arg Ile Asn 
145                 150                 155                 160 

Ala Ala Lys Ala His Ser Ile Gly Leu Val Asn Arg Val Val Ser Asp 
                165                 170                 175     

Glu Arg Leu Leu Ala Glu Thr Val Ser Leu Val Lys Asn Ile Cys Asn 
            180                 185                 190         

Arg Gly Leu Leu Ser Leu Arg Val Ala Lys Glu Val Ile Asp Ala Gly 
        195                 200                 205             

Ala Gly Ile Asp Leu Ala Thr Ala Cys Leu Met Glu Arg Asp Ala Phe 
    210                 215                 220                 

Ala Leu Cys Phe Ser Thr Asp Asp Gln Lys Glu Gly Met Arg Ala Phe 
225                 230                 235                 240 

Met Glu Lys Arg Glu Pro Arg Phe 
                245             

<210>   59
<211>   261
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   59
Met Arg Asn Leu Thr Glu Thr Phe Thr Thr Tyr Arg Val Glu Asp His 
                5                   10                  15      

Val Ala Val Leu Thr Leu Asn Arg Pro Gln Ala Ile Asn Ala Leu Ser 
            20                  25                  30          

Arg Glu Val Leu Ser Glu Ile Gly Ala His Leu Ala Met Leu Asp Leu 
        35                  40                  45              

Lys Asp Val Arg Val Leu Val Ile Arg Gly Glu Gly Arg Val Phe Cys 
    50                  55                  60                  

Ala Gly Ala Asp Ile Gly Gln Met Gln His Met Ser Ala Val Glu Ala 
65                  70                  75                  80  

Glu Ser Met Ala Arg Leu Gly Gln Arg Val Phe Gln Ala Ile Glu Gln 
                85                  90                  95      

Leu Pro Ile Pro Val Ile Ala Leu Ile His Gly Gly Ala Phe Gly Gly 
            100                 105                 110         

Gly Leu Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Ala Ala Ala Gly 
        115                 120                 125             

Ala Val Val Gly Leu Pro Glu Val Thr Leu Gly Val Asn Pro Ser Phe 
    130                 135                 140                 

Gly Gly Thr Tyr Arg Leu Pro Arg Ala Ile Gly Phe Ala Arg Ala Leu 
145                 150                 155                 160 

Ser Met Met Leu Leu Gly Glu Arg Ile Pro Val Glu Lys Ala Leu Glu 
                165                 170                 175     

Tyr Gly Leu Val Asn Glu Val Val Ala Pro Asp Glu Leu Glu Ala Arg 
            180                 185                 190         

Gly Met Asp Leu Ala Arg Lys Leu Ala Ser Gln Ser Ser Ala Ala Met 
        195                 200                 205             

Ala Ala Ile Lys Arg Ser Ala His His Gly Phe Gly Gln Asp Pro Ala 
    210                 215                 220                 

Arg Ala Gln Ala Tyr Glu Ala Ala Gln Phe Gly Leu Cys Phe Ala Ser 
225                 230                 235                 240 

Gly Asp Ala His Glu Gly Met Ala Ala Phe Lys Glu Lys Arg Gln Ala 
                245                 250                 255     

Arg Phe His Glu Asp 
            260     

<210>   60
<211>   261
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   60
Met Arg Asn Leu Thr Glu Thr Phe Thr Thr Tyr Arg Val Glu Asp His 
                5                   10                  15      

Val Ala Val Leu Thr Leu Asn Arg Pro Gln Ala Leu Asn Ala Leu Ser 
            20                  25                  30          

Arg Glu Val Leu Ser Glu Ile Gly Ala His Leu Ala Met Leu Asp Leu 
        35                  40                  45              

Lys Asp Val Arg Val Leu Val Ile Arg Gly Glu Gly Arg Val Phe Cys 
    50                  55                  60                  

Ala Gly Ala Asp Ile Gly Gln Met Gln His Met Ser Ala Val Glu Ala 
65                  70                  75                  80  

Glu Ser Met Ala Arg Leu Gly Gln Arg Val Phe Gln Ala Ile Glu Gln 
                85                  90                  95      

Leu Pro Ile Pro Val Ile Ala Leu Ile His Gly Gly Ala Phe Gly Gly 
            100                 105                 110         

Gly Leu Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Ala Ala Ala Gly 
        115                 120                 125             

Ala Val Val Gly Leu Pro Glu Val Thr Leu Gly Val Asn Pro Ser Phe 
    130                 135                 140                 

Gly Gly Thr Tyr Arg Leu Pro Arg Ala Ile Gly Phe Ala Arg Ala Leu 
145                 150                 155                 160 

Ser Met Met Leu Leu Gly Glu Arg Ile Pro Val Asp Lys Ala Leu Glu 
                165                 170                 175     

Tyr Gly Leu Val Asn Glu Val Val Ala Pro Asp Glu Leu Glu Ala Arg 
            180                 185                 190         

Gly Met Asp Leu Ala Arg Lys Leu Ala Ser Gln Ser Ser Ala Ala Met 
        195                 200                 205             

Ala Ala Ile Lys Arg Ser Ala His His Gly Phe Gly Gln Asp Pro Ala 
    210                 215                 220                 

Arg Ala Gln Ala Tyr Glu Ala Ala Gln Phe Gly Leu Cys Phe Ala Ser 
225                 230                 235                 240 

Gly Asp Ala His Glu Gly Met Ala Ala Phe Lys Glu Lys Arg Gln Ala 
                245                 250                 255     

Arg Phe His Glu Asp 
            260     

<210>   61
<211>   261
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   61
Met Arg Asn Leu Thr Glu Thr Phe Thr Thr Tyr Arg Ile Glu Asp His 
                5                   10                  15      

Val Ala Val Leu Thr Leu Asn Arg Pro Gln Ala Leu Asn Ala Leu Ser 
            20                  25                  30          

Arg Glu Val Leu Ser Glu Ile Gly Ala His Leu Ala Met Leu Asp Leu 
        35                  40                  45              

Lys Asp Val Arg Val Leu Val Ile Arg Gly Glu Gly Arg Val Phe Cys 
    50                  55                  60                  

Ala Gly Ala Asp Ile Gly Gln Met Gln His Met Ser Ala Val Glu Ala 
65                  70                  75                  80  

Glu Ser Met Ala Arg Leu Gly Gln Arg Val Phe Gln Ala Ile Glu Gln 
                85                  90                  95      

Leu Pro Ile Pro Val Ile Ala Leu Ile His Gly Gly Ala Phe Gly Gly 
            100                 105                 110         

Gly Leu Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Ala Ala Ala Gly 
        115                 120                 125             

Ala Val Val Gly Leu Pro Glu Val Thr Leu Gly Val Asn Pro Ser Phe 
    130                 135                 140                 

Gly Gly Thr Tyr Arg Leu Pro Arg Ala Ile Gly Phe Ala Arg Ala Leu 
145                 150                 155                 160 

Ser Met Met Leu Leu Gly Glu Arg Ile Pro Val Glu Lys Ala Leu Glu 
                165                 170                 175     

Tyr Gly Leu Val Asn Glu Val Val Ala Pro Asp Glu Leu Glu Ala Arg 
            180                 185                 190         

Gly Met Asp Leu Ala Arg Lys Leu Ala Ser Gln Ser Ser Ala Ala Met 
        195                 200                 205             

Ala Ala Ile Lys Arg Ser Ala His His Gly Phe Gly Gln Asp Pro Ala 
    210                 215                 220                 

Arg Ala Gln Ala Tyr Glu Ala Ala Gln Phe Gly Leu Cys Phe Ala Ser 
225                 230                 235                 240 

Gly Asp Ala His Glu Gly Met Ala Ala Phe Lys Glu Lys Arg Gln Ala 
                245                 250                 255     

Arg Phe His Glu Asp 
            260     

<210>   62
<211>   261
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   62
Met Arg Asn Leu Thr Glu Thr Phe Thr Thr Tyr Arg Val Glu Asp His 
                5                   10                  15      

Val Ala Val Leu Thr Leu Asn Arg Pro Gln Ala Leu Asn Ala Leu Ser 
            20                  25                  30          

Arg Glu Val Leu Ser Glu Ile Gly Ala His Leu Ala Met Leu Asp Leu 
        35                  40                  45              

Lys Asp Val Arg Val Leu Val Ile Arg Gly Glu Gly Arg Val Phe Cys 
    50                  55                  60                  

Ala Gly Ala Asp Ile Gly Gln Met Gln His Met Ser Ala Val Glu Ala 
65                  70                  75                  80  

Glu Ser Met Ala Arg Leu Gly Gln Arg Val Phe Gln Ala Ile Glu Gln 
                85                  90                  95      

Leu Pro Ile Pro Val Ile Ala Leu Ile His Gly Gly Ala Phe Gly Gly 
            100                 105                 110         

Gly Leu Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Ala Ala Ala Gly 
        115                 120                 125             

Ala Val Val Gly Leu Pro Glu Val Thr Leu Gly Val Asn Pro Ser Phe 
    130                 135                 140                 

Gly Gly Thr Tyr Arg Leu Pro Arg Ala Ile Gly Phe Ala Arg Ala Leu 
145                 150                 155                 160 

Ser Met Met Leu Leu Gly Glu Arg Ile Pro Val Glu Lys Ala Leu Glu 
                165                 170                 175     

Tyr Gly Leu Val Asn Glu Val Val Ala Pro Asp Glu Leu Glu Ala Arg 
            180                 185                 190         

Gly Met Glu Leu Ala Arg Lys Leu Ala Ser Gln Ser Ser Ala Ala Met 
        195                 200                 205             

Ala Ala Ile Lys Arg Ser Ala His His Gly Phe Gly Gln Asp Pro Ala 
    210                 215                 220                 

Arg Ala Gln Ala Tyr Glu Ala Ala Gln Phe Gly Leu Cys Phe Ala Ser 
225                 230                 235                 240 

Gly Asp Ala His Glu Gly Met Ala Ala Phe Lys Glu Lys Arg Gln Ala 
                245                 250                 255     

Arg Phe His Glu Asp 
            260     

<210>   63
<211>   261
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   63
Met Arg Asn Leu Thr Glu Thr Phe Thr Thr Tyr Arg Val Glu Asp His 
                5                   10                  15      

Val Ala Val Leu Thr Leu Asn Arg Pro Gln Ala Leu Asn Ala Leu Ser 
            20                  25                  30          

Arg Glu Val Leu Ser Asp Ile Gly Ala His Leu Ala Met Leu Asp Leu 
        35                  40                  45              

Lys Asp Val Arg Val Leu Val Ile Arg Gly Glu Gly Arg Val Phe Cys 
    50                  55                  60                  

Ala Gly Ala Asp Ile Gly Gln Met Gln His Met Ser Ala Val Glu Ala 
65                  70                  75                  80  

Glu Ser Met Ala Arg Leu Gly Gln Arg Val Phe Gln Ala Ile Glu Gln 
                85                  90                  95      

Leu Pro Ile Pro Val Ile Ala Leu Ile His Gly Gly Ala Phe Gly Gly 
            100                 105                 110         

Gly Leu Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Ala Ala Ala Gly 
        115                 120                 125             

Ala Val Val Gly Leu Pro Glu Val Thr Leu Gly Val Asn Pro Ser Phe 
    130                 135                 140                 

Gly Gly Thr Tyr Arg Leu Pro Arg Ala Ile Gly Phe Ala Arg Ala Leu 
145                 150                 155                 160 

Ser Met Met Leu Leu Gly Glu Arg Ile Pro Val Glu Lys Ala Leu Glu 
                165                 170                 175     

Tyr Gly Leu Val Asn Glu Val Val Ala Pro Asp Glu Leu Glu Ala Arg 
            180                 185                 190         

Gly Met Asp Leu Ala Arg Lys Leu Ala Ser Gln Ser Ser Ala Ala Met 
        195                 200                 205             

Ala Ala Ile Lys Arg Ser Ala His His Gly Phe Gly Gln Asp Pro Ala 
    210                 215                 220                 

Arg Ala Gln Ala Tyr Glu Ala Ala Gln Phe Gly Leu Cys Phe Ala Ser 
225                 230                 235                 240 

Gly Asp Ala His Glu Gly Met Ala Ala Phe Lys Glu Lys Arg Gln Ala 
                245                 250                 255     

Arg Phe His Glu Asp 
            260     

<210>   64
<211>   786
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   64
gtgaggaatt tgacagagac gttcaccacg taccgcgtgg aggatcatgt ggcggttttg       60

acgctcaatc gtccgcaggc tattaacgcg ctttctcgag aagtgctgtc ggaaatcggt      120

gcgcatcttg cgatgttgga tctcaaggac gtccgcgttc tcgtcatccg cggcgagggc      180

cgggtgttct gcgcgggcgc ggacatcggc cagatgcagc acatgagcgc cgtggaggcc      240

gagagcatgg cgcgccttgg gcagcgcgtg ttccaggcca tcgaacagct gcccattccg      300

gtgattgcgc tgattcacgg cggggcgttt ggcggggggc ttgaactcgc gctcgcgtgc      360

gattttcgga ttgcggccgc aggcgccgtc gtcgggctgc ccgaggtgac gctgggggtc      420

aacccgagtt tcggcgggac gtaccggctc ccgcgcgcca tcgggttcgc gcgcgcgctc      480

tcgatgatgc ttctggggga gcggatcccg gtcgagaagg ccctggagta cgggctcgtg      540

aacgaggtgg tggcgcctga cgagctcgag gcgaggggca tggatctcgc gcgaaaactc      600

gcgagccagt cgagcgccgc gatggcggcc atcaagcggt cggcccacca cgggtttggg      660

caggatccag ctcgcgcgca ggcgtatgag gcggcgcagt tcggcctgtg ctttgcttct      720

ggggacgcgc acgagggcat ggcggccttc aaggagaagc gccaggcgag gtttcacgag      780

gactga                                                                 786


<210>   65
<211>   786
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   65
gtgaggaatt tgacagagac gttcaccacg taccgcgtgg aggatcatgt ggcggttttg       60

acgctcaatc gtccgcaggc tttgaacgcg ctttctcgag aagtgctgtc ggaaatcggt      120

gcgcatcttg cgatgttgga tctcaaggac gtccgcgttc tcgtcatccg cggcgagggc      180

cgggtgttct gcgcgggcgc ggacatcggc cagatgcagc acatgagcgc cgtggaggcc      240

gagagcatgg cgcgccttgg gcagcgcgtg ttccaggcca tcgaacagct gcccattccg      300

gtgattgcgc tgattcacgg cggggcgttt ggcggggggc ttgaactcgc gctcgcgtgc      360

gattttcgga ttgcggccgc aggcgccgtc gtcgggctgc ccgaggtgac gctgggggtc      420

aacccgagtt tcggcgggac gtaccggctc ccgcgcgcca tcgggttcgc gcgcgcgctc      480

tcgatgatgc ttctggggga gcggatcccg gtcgataagg ccctggagta cgggctcgtg      540

aacgaggtgg tggcgcctga cgagctcgag gcgaggggca tggatctcgc gcgaaaactc      600

gcgagccagt cgagcgccgc gatggcggcc atcaagcggt cggcccacca cgggtttggg      660

caggatccag ctcgcgcgca ggcgtatgag gcggcgcagt tcggcctgtg ctttgcttct      720

ggggacgcgc acgagggcat ggcggccttc aaggagaagc gccaggcgag gtttcacgag      780

gactga                                                                 786


<210>   66
<211>   786
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   66
gtgaggaatt tgacagagac gttcaccacg taccgcattg aggatcatgt ggcggttttg       60

acgctcaatc gtccgcaggc tttgaacgcg ctttctcgag aagtgctgtc ggaaatcggt      120

gcgcatcttg cgatgttgga tctcaaggac gtccgcgttc tcgtcatccg cggcgagggc      180

cgggtgttct gcgcgggcgc ggacatcggc cagatgcagc acatgagcgc cgtggaggcc      240

gagagcatgg cgcgccttgg gcagcgcgtg ttccaggcca tcgaacagct gcccattccg      300

gtgattgcgc tgattcacgg cggggcgttt ggcggggggc ttgaactcgc gctcgcgtgc      360

gattttcgga ttgcggccgc aggcgccgtc gtcgggctgc ccgaggtgac gctgggggtc      420

aacccgagtt tcggcgggac gtaccggctc ccgcgcgcca tcgggttcgc gcgcgcgctc      480

tcgatgatgc ttctggggga gcggatcccg gtcgagaagg ccctggagta cgggctcgtg      540

aacgaggtgg tggcgcctga cgagctcgag gcgaggggca tggatctcgc gcgaaaactc      600

gcgagccagt cgagcgccgc gatggcggcc atcaagcggt cggcccacca cgggtttggg      660

caggatccag ctcgcgcgca ggcgtatgag gcggcgcagt tcggcctgtg ctttgcttct      720

ggggacgcgc acgagggcat ggcggccttc aaggagaagc gccaggcgag gtttcacgag      780

gactga                                                                 786


<210>   67
<211>   786
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   67
gtgaggaatt tgacagagac gttcaccacg taccgcgtgg aggatcatgt ggcggttttg       60

acgctcaatc gtccgcaggc tttgaacgcg ctttctcgag aagtgctgtc ggaaatcggt      120

gcgcatcttg cgatgttgga tctcaaggac gtccgcgttc tcgtcatccg cggcgagggc      180

cgggtgttct gcgcgggcgc ggacatcggc cagatgcagc acatgagcgc cgtggaggcc      240

gagagcatgg cgcgccttgg gcagcgcgtg ttccaggcca tcgaacagct gcccattccg      300

gtgattgcgc tgattcacgg cggggcgttt ggcggggggc ttgaactcgc gctcgcgtgc      360

gattttcgga ttgcggccgc aggcgccgtc gtcgggctgc ccgaggtgac gctgggggtc      420

aacccgagtt tcggcgggac gtaccggctc ccgcgcgcca tcgggttcgc gcgcgcgctc      480

tcgatgatgc ttctggggga gcggatcccg gtcgagaagg ccctggagta cgggctcgtg      540

aacgaggtgg tggcgcctga cgagctcgag gcgaggggca tggaactcgc gcgaaaactc      600

gcgagccagt cgagcgccgc gatggcggcc atcaagcggt cggcccacca cgggtttggg      660

caggatccag ctcgcgcgca ggcgtatgag gcggcgcagt tcggcctgtg ctttgcttct      720

ggggacgcgc acgagggcat ggcggccttc aaggagaagc gccaggcgag gtttcacgag      780

gactga                                                                 786


<210>   68
<211>   786
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   68
gtgaggaatt tgacagagac gttcaccacg taccgcgtgg aggatcatgt ggcggttttg       60

acgctcaatc gtccgcaggc tttgaacgcg ctttctcgag aagtgctgtc ggatatcggt      120

gcgcatcttg cgatgttgga tctcaaggac gtccgcgttc tcgtcatccg cggcgagggc      180

cgggtgttct gcgcgggcgc ggacatcggc cagatgcagc acatgagcgc cgtggaggcc      240

gagagcatgg cgcgccttgg gcagcgcgtg ttccaggcca tcgaacagct gcccattccg      300

gtgattgcgc tgattcacgg cggggcgttt ggcggggggc ttgaactcgc gctcgcgtgc      360

gattttcgga ttgcggccgc aggcgccgtc gtcgggctgc ccgaggtgac gctgggggtc      420

aacccgagtt tcggcgggac gtaccggctc ccgcgcgcca tcgggttcgc gcgcgcgctc      480

tcgatgatgc ttctggggga gcggatcccg gtcgagaagg ccctggagta cgggctcgtg      540

aacgaggtgg tggcgcctga cgagctcgag gcgaggggca tggatctcgc gcgaaaactc      600

gcgagccagt cgagcgccgc gatggcggcc atcaagcggt cggcccacca cgggtttggg      660

caggatccag ctcgcgcgca ggcgtatgag gcggcgcagt tcggcctgtg ctttgcttct      720

ggggacgcgc acgagggcat ggcggccttc aaggagaagc gccaggcgag gtttcacgag      780

gactga                                                                 786


<210>   69
<211>   376
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   69
Met Met Glu Trp Asp Val Tyr Glu Ala Arg Arg Ala Leu His Gln Ile 
                5                   10                  15      

Pro Glu Pro Gly Phe Arg Glu Phe Glu Thr Gln Lys Leu Val Leu Ser 
            20                  25                  30          

Tyr Leu Gln Ala Leu Pro Gln Glu His Leu Glu Ile Arg Thr Trp Glu 
        35                  40                  45              

Thr Gly Val Ile Ala Leu Val Lys Gly His Ser Pro Lys Arg Arg Val 
    50                  55                  60                  

Gly Trp Arg Ala Asp Met Asp Gly Leu Pro Val Ala Glu Glu Thr Gly 
65                  70                  75                  80  

Val Pro Tyr Ala Ser Arg His Pro Gly Met Met His Ala Cys Gly His 
                85                  90                  95      

Asp Val His Met Ala Val Ala Leu Gly Leu Ala Gln His Phe Ala His 
            100                 105                 110         

Asn Pro Pro Pro Asp Asp Leu Val Leu Val Phe Gln Pro Ala Glu Glu 
        115                 120                 125             

Gly Pro Gly Gly Ala Gln Pro Met Leu Ala Ser Glu Ala Phe Gln Ala 
    130                 135                 140                 

Val Arg Pro Glu Met Ile Phe Ala Leu His Val Gln Pro Asp Met Ala 
145                 150                 155                 160 

Val Gly Glu Ile Gly Ile Arg Pro Gly Val Leu Phe Ala Asn Thr Ser 
                165                 170                 175     

Glu Leu Phe Ile His Leu Val Gly Gln Gly Gly His Ala Ala Tyr Pro 
            180                 185                 190         

His Arg Ala Asn Asp Met Val Val Ala Gly Ala His Leu Val Thr Ala 
        195                 200                 205             

Leu Gln Thr Ile Val Ala Arg Asn Val Asp Pro Leu Asp Ser Ala Val 
    210                 215                 220                 

Ile Thr Val Gly Arg Leu Glu Ser Gly Thr Lys Met Asn Ile Ile Ala 
225                 230                 235                 240 

Glu Arg Ala Arg Leu Glu Gly Thr Val Arg Ala Leu Asn Ala Ala Thr 
                245                 250                 255     

Met Pro Arg Leu Lys Asn Arg Ile Glu Ala Val Val Ala Gly Ile Glu 
            260                 265                 270         

Arg Met Phe Asn Cys Gln Ala Glu Ile Asp Tyr Gly Ala Asn Tyr Tyr 
        275                 280                 285             

Gln Val Tyr Asn Asp Glu Arg Leu Thr Arg Gly Phe Met Gln Phe Val 
    290                 295                 300                 

Glu Glu Ala Gly Leu Ala Asp Val His Glu Val Pro Pro Ala Met Thr 
305                 310                 315                 320 

Gly Glu Asp Phe Gly Tyr Phe Leu Arg Glu Ile Pro Gly Phe Leu Phe 
                325                 330                 335     

Trp Leu Gly Ala Ala Thr Pro Tyr Gly Leu His His Ala Lys Met Leu 
            340                 345                 350         

Pro Asp Glu Arg Cys Ile Asp Val Ala Leu Arg Val Leu Ile Pro Tyr 
        355                 360                 365             

Phe Ala Glu Arg Arg Tyr Glu Ala 
    370                 375     

<210>   70
<211>   1131
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   70
gtgatggagt gggatgtgta cgaagcgcgg cgcgccctgc accaaattcc agagcccgga       60

tttcgggagt ttgagacgca gaaactggtg ctctcgtatc tgcaggcgct cccacaggag      120

cacctggaga tccgcacgtg ggagacgggc gtgattgcgc tcgtgaaggg acacagtccg      180

aagcgacgcg tgggctggcg cgcggacatg gacgggctgc ccgtggcgga ggagacgggc      240

gtcccgtatg cgtcgcgcca tccgggcatg atgcacgcct gcgggcacga cgtgcacatg      300

gccgtcgcgc tcggcctcgc tcagcacttc gcccacaacc ctccgccgga cgatctcgtc      360

ctcgtctttc agcccgccga ggagggcccg ggcggcgcac agccgatgct cgcgagcgag      420

gcgtttcagg ccgtgcggcc tgagatgatc ttcgcactgc acgtgcagcc cgacatggct      480

gtaggcgaga ttggcatccg gcccggcgtg ctgtttgcga acacgtccga gctgttcatc      540

catctcgtcg gccaaggagg gcacgcggcc tatccgcacc gggccaacga catggtggtg      600

gcgggtgcac acctcgtgac ggcgctgcag accatcgtgg cgcgaaatgt ggatccgtta      660

gacagcgcgg tcatcaccgt ggggcggctg gagtcgggca cgaagatgaa tatcatcgcg      720

gagcgcgcgc gcctcgaggg cactgtccgg gcactcaacg cggccaccat gccccgcctc      780

aagaaccgaa ttgaggcggt ggtggcaggg attgagcgga tgttcaactg ccaggccgag      840

atcgactacg gcgcgaatta ctaccaggtg tacaacgacg agcgcctcac ccgcgggttc      900

atgcagtttg tcgaggaggc cgggctcgcc gacgtgcacg aggttccgcc cgccatgacg      960

ggcgaggatt tcggctactt tctgcgcgaa atcccgggtt ttctgttctg gctcggcgcg     1020

gccacgccgt acggcctgca ccacgccaag atgctcccgg acgagcgatg catcgacgtg     1080

gcgctgcgcg tgctcatccc gtacttcgcc gagcggcgat acgaggcttg a              1131


<210>   71
<211>   361
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   71
Arg Arg Asp Leu His Gln Ile Pro Glu Leu Gly Phe Gln Glu Phe Lys 
                5                   10                  15      

Thr Gln Gln Tyr Leu Leu Arg Tyr Ile Gln Ser Leu Pro Gln Glu Arg 
            20                  25                  30          

Leu Gln Val Arg Thr Trp Lys Thr Gly Ile Phe Val Lys Val Asn Gly 
        35                  40                  45              

Thr Ser Pro Arg Lys Thr Ile Gly Tyr Arg Ala Asp Met Asp Gly Leu 
    50                  55                  60                  

Pro Ile Arg Glu Glu Thr Gly Leu Pro Tyr Arg Ser Lys His Glu Gly 
65                  70                  75                  80  

Arg Met His Ala Cys Gly His Asp Val His Met Ser Ile Ala Leu Gly 
                85                  90                  95      

Val Leu Thr His Phe Ala His His Pro Leu Lys Asp Asp Leu Leu Phe 
            100                 105                 110         

Val Phe Gln Pro Ala Glu Glu Gly Pro Gly Gly Ala Lys Pro Met Leu 
        115                 120                 125             

Glu Ser Asp Ile Met Arg Glu Trp Lys Pro Asp Ile Ile Val Ala Leu 
    130                 135                 140                 

His Ile Ala Pro Glu Tyr Pro Val Gly Thr Ile Ala Thr Lys Glu Gly 
145                 150                 155                 160 

Leu Leu Phe Ala Asn Thr Ser Glu Leu Phe Ile Asp Leu Lys Gly Lys 
                165                 170                 175     

Gly Gly His Ala Ala Phe Pro His Leu Ala Asn Asp Met Val Val Ala 
            180                 185                 190         

Ala Cys Ala Leu Val Thr Gln Leu Gln Ser Ile Val Ala Arg Asn Val 
        195                 200                 205             

Asp Pro Leu Asp Ser Ala Val Ile Thr Ile Gly Lys Ile Ala Gly Gly 
    210                 215                 220                 

Thr Val Gln Asn Val Ile Ala Glu His Ala Arg Leu Glu Gly Thr Ile 
225                 230                 235                 240 

Arg Thr Leu Ser Thr Ala Ala Met Gln Lys Val Lys Arg Arg Ile Glu 
                245                 250                 255     

Ala Ile Val His Gly Ile Glu Val Ala Tyr Glu Cys Glu Ala Ser Ile 
            260                 265                 270         

Asp Tyr Gly Ala Met Tyr His Glu Val Tyr Asn Asp Pro Asp Leu Thr 
        275                 280                 285             

Ala Glu Phe Met Lys Phe Ala Lys Ala His Gly Gly Val Asn Val Ile 
    290                 295                 300                 

Arg Cys Lys Glu Ala Met Thr Gly Glu Asp Phe Gly Tyr Met Leu Ala 
305                 310                 315                 320 

Asp Ile Pro Gly Phe Met Phe Trp Leu Gly Val Ala Ser Pro Tyr Gly 
                325                 330                 335     

Leu His His Ala Lys Leu Ala Pro Asn Glu Glu Ala Ile Asp Arg Ala 
            340                 345                 350         

Ile Ala Phe Leu Ile Asp Tyr Phe Ser 
        355                 360     

<210>   72
<211>   361
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   72
Arg Arg Asp Leu His Lys Ile Pro Glu Leu Gly Phe Gln Glu Phe Lys 
                5                   10                  15      

Thr Gln Gln Tyr Leu Leu Asn Tyr Ile Gln Ser Leu Pro Gln Glu Arg 
            20                  25                  30          

Leu Asp Val Arg Thr Trp Lys Thr Gly Ile Phe Val Lys Val Ser Gly 
        35                  40                  45              

Thr Ala Pro Arg Lys Thr Ile Gly Tyr Arg Ala Asp Ile Asp Gly Leu 
    50                  55                  60                  

Pro Ile Ser Glu Glu Thr Gly Leu Pro Tyr Arg Ser Glu His Ala Gly 
65                  70                  75                  80  

Gln Met His Ala Cys Gly His Asp Val His Met Ser Ile Ala Leu Gly 
                85                  90                  95      

Val Leu Thr His Phe Ala His Asn Pro Ile Arg Asp Asp Leu Leu Phe 
            100                 105                 110         

Ile Phe Gln Pro Ala Glu Glu Gly Pro Gly Gly Ala Lys Pro Met Leu 
        115                 120                 125             

Glu Ser Asp Ile Met Arg Glu Trp Lys Pro Asp Met Ile Val Ala Leu 
    130                 135                 140                 

His Ile Ala Pro Glu Tyr Pro Val Gly Thr Ile Ala Thr Lys Glu Gly 
145                 150                 155                 160 

Leu Leu Phe Ala Asn Thr Ser Glu Leu Phe Ile Asp Leu Lys Gly Lys 
                165                 170                 175     

Gly Gly His Ala Ala Phe Pro His Leu Ala Asn Asp Met Val Val Ala 
            180                 185                 190         

Ala Cys Ala Leu Val Thr Gln Leu Gln Ser Ile Val Ala Arg Asn Val 
        195                 200                 205             

Asp Pro Leu Asp Ser Ala Val Ile Thr Ile Gly Lys Ile Thr Ser Gly 
    210                 215                 220                 

Thr Val Gln Asn Val Ile Ala Glu His Ala Arg Leu Glu Gly Thr Ile 
225                 230                 235                 240 

Arg Thr Leu Ser Ile Asp Ala Met Gln Ala Val Lys Arg Arg Ile Glu 
                245                 250                 255     

Ala Leu Val Arg Gly Val Glu Val Ala Tyr Glu Cys Glu Ala Val Ile 
            260                 265                 270         

Asp Tyr Gly Ala Met Tyr His Glu Val Tyr Asn Asn Pro Ala Leu Thr 
        275                 280                 285             

Thr Glu Phe Ile Gln Phe Ala Glu Thr His Thr Asp Met Asn Val Ile 
    290                 295                 300                 

Arg Cys Lys Glu Ala Met Thr Gly Glu Asp Phe Gly Tyr Met Leu Ala 
305                 310                 315                 320 

Glu Ile Pro Gly Phe Met Phe Trp Leu Gly Val Asp Ser Pro Tyr Gly 
                325                 330                 335     

Leu His His Ala Lys Leu Val Pro Asn Glu Ala Ala Ile Asp Arg Ala 
            340                 345                 350         

Ile Ala Phe Leu Ile Ser Tyr Phe Ser 
        355                 360     

<210>   73
<211>   361
<212>   PRT
<213>   Bacillus weihenstephanensis KBAB4

<400>   73
Gln Val Arg Arg Asp Leu His Lys Ile Pro Glu Ile Gly Phe Lys Glu 
                5                   10                  15      

Trp Lys Thr Gln Gln Tyr Ile Leu Asp Tyr Ile Gly Thr Leu Pro Asn 
            20                  25                  30          

Glu Tyr Leu Glu Val Lys Thr Trp Lys Thr Gly Val Ile Val Lys Val 
        35                  40                  45              

Asn Gly Lys Asn Pro Glu Lys Ile Ile Gly Tyr Arg Ala Asp Ile Asp 
    50                  55                  60                  

Gly Leu Pro Ile Thr Glu Glu Thr Gly Tyr Glu Tyr Ser Ser Val His 
65                  70                  75                  80  

Glu Gly Met Met His Ala Cys Gly His Asp Leu His Ala Thr Ile Gly 
                85                  90                  95      

Leu Gly Leu Leu Thr Ala Ala Val Ser Glu Arg Ile Asp Asp Asp Leu 
            100                 105                 110         

Val Phe Ile Phe Gln Pro Ala Glu Glu Gly Pro Gly Gly Ala Leu Pro 
        115                 120                 125             

Met Leu Glu Ser Asp Glu Leu Lys Glu Trp Lys Pro Asn Met Ile Leu 
    130                 135                 140                 

Gly Leu His Ile Ala Pro Glu Tyr Ser Val Gly Thr Ile Ala Thr Lys 
145                 150                 155                 160 

Glu Gly Leu Leu Phe Ala Asn Thr Ser Glu Leu Tyr Val Asp Leu Lys 
                165                 170                 175     

Gly Lys Gly Gly His Ala Ala Tyr Pro His Thr Ala Asn Asp Met Ile 
            180                 185                 190         

Val Ala Ala Ser His Leu Val Thr Gln Leu Gln Ser Val Ile Ser Arg 
        195                 200                 205             

Asn Val Asn Pro Leu Asp Ser Ala Val Ile Thr Ile Gly Lys Ile Thr 
    210                 215                 220                 

Gly Gly Thr Val Gln Asn Ile Ile Ala Glu Lys Ser Arg Leu Glu Gly 
225                 230                 235                 240 

Thr Ile Arg Thr Leu Ser Val Glu Ser Met Lys Arg Val Lys Ser Arg 
                245                 250                 255     

Ile Glu Ala Ile Val Ala Gly Ile Glu Ala Ser Phe Gln Cys Glu Ala 
            260                 265                 270         

Val Ile Asp Tyr Gly Ala Met Tyr His Gln Val Tyr Asn His Glu Glu 
        275                 280                 285             

Leu Thr Arg Glu Phe Met Gln Phe Thr Arg Glu Gln Thr Thr Met Asp 
    290                 295                 300                 

Val Ile Thr Cys Thr Glu Ala Met Thr Gly Glu Asp Phe Gly Tyr Met 
305                 310                 315                 320 

Leu Arg Glu Ile Pro Gly Phe Met Phe Trp Leu Gly Val Asn Ser Glu 
                325                 330                 335     

Tyr Gly Leu His His Ala Lys Leu Lys Pro Asp Glu Glu Val Ile Glu 
            340                 345                 350         

Lys Ala Ile Val Phe Leu Asn Gln Tyr 
        355                 360     

<210>   74
<211>   361
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   74
Gln Ile Arg Arg Asp Leu His Gln Ile Pro Glu Leu Gly Phe Gln Glu 
                5                   10                  15      

Trp Lys Thr Gln Gln Tyr Ile Leu Asn Tyr Ile Glu Thr Leu Pro Asn 
            20                  25                  30          

Glu His Ile Glu Val Lys Thr Trp Lys Thr Gly Val Ile Val Lys Val 
        35                  40                  45              

Lys Gly Lys Asn Pro Val Lys Thr Ile Gly Tyr Arg Ala Asp Met Asp 
    50                  55                  60                  

Gly Leu Pro Ile Val Glu Glu Thr Gly Tyr Glu Phe Ala Ser Thr His 
65                  70                  75                  80  

Glu Gly Met Met His Ala Cys Gly His Asp Phe His Thr Thr Ile Gly 
                85                  90                  95      

Leu Gly Leu Leu Thr Ala Thr Val Asn Asp Arg Ile Asp Asp Asp Leu 
            100                 105                 110         

Val Phe Leu Phe Gln Pro Ala Glu Glu Gly Pro Gly Gly Ala Leu Pro 
        115                 120                 125             

Met Leu Glu Ser Glu Glu Leu Lys Glu Trp Lys Pro Asn Met Ile Leu 
    130                 135                 140                 

Gly Leu His Ile Ala Pro Glu Tyr Pro Val Gly Thr Ile Ala Thr Lys 
145                 150                 155                 160 

Glu Gly Leu Leu Phe Ala Asn Thr Ser Glu Leu Tyr Ile Asp Leu Lys 
                165                 170                 175     

Gly Lys Gly Gly His Ala Ala Tyr Pro His Met Ala Asn Asp Met Ile 
            180                 185                 190         

Val Ala Ala Ser His Leu Val Thr Gln Leu Gln Ser Val Ile Ser Arg 
        195                 200                 205             

Asn Val Asn Pro Leu Asp Ser Ala Val Ile Thr Ile Gly Lys Ile Thr 
    210                 215                 220                 

Gly Gly Thr Val Gln Asn Ile Ile Ala Glu Lys Ser Arg Leu Glu Gly 
225                 230                 235                 240 

Thr Ile Arg Thr Leu Ser Val Glu Ser Met Lys Arg Val Lys Asp Arg 
                245                 250                 255     

Ile Glu Ala Ile Val Ala Gly Ile Glu Ala Ala Phe Gln Cys Glu Ala 
            260                 265                 270         

Val Ile Asp Tyr Gly Ala Met Tyr His Gln Val Tyr Asn His Glu Ala 
        275                 280                 285             

Leu Thr Lys Glu Phe Met Glu Phe Ala Ser Lys Asp Thr Asn Met Asn 
    290                 295                 300                 

Val Val Thr Cys Lys Glu Ala Met Thr Gly Glu Asp Phe Gly Tyr Met 
305                 310                 315                 320 

Leu Arg Asp Ile Pro Gly Phe Met Phe Trp Leu Gly Val Asp Ser Glu 
                325                 330                 335     

Tyr Gly Leu His His Ala Lys Leu Lys Pro Asn Glu Ala Ala Ile Asp 
            340                 345                 350         

Arg Ala Ile Glu Phe Leu Asn Gln Tyr 
        355                 360     

<210>   75
<211>   367
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   75
Met Glu Thr Asn Leu Ile Ala Ile Arg Arg Asp Leu His Arg Ile Pro 
                5                   10                  15      

Glu Leu Gly Tyr Lys Glu His Lys Thr Gln Arg Tyr Ile Leu Asp Phe 
            20                  25                  30          

Ile Ser Arg Leu Pro Lys Gly His Leu Glu Val Lys Thr Trp Lys Thr 
        35                  40                  45              

Gly Val Leu Val Lys Val Lys Gly Thr Cys Pro Glu Lys Lys Ile Gly 
    50                  55                  60                  

Tyr Arg Thr Asp Ile Asp Gly Leu Pro Ile Lys Glu Glu Thr Gly Phe 
65                  70                  75                  80  

Pro Phe Gln Ser Glu His Glu Gly Asn Met His Ala Cys Gly His Asp 
                85                  90                  95      

Phe His Met Thr Ile Ala Leu Gly Ile Leu Ser His Phe Ala Ser Arg 
            100                 105                 110         

Pro Val Lys Asp Asp Leu Ile Phe Ile Phe Gln Pro Ala Glu Glu Gly 
        115                 120                 125             

Pro Gly Gly Ala Lys Ala Met Leu Glu Glu Val Leu His Asp Glu Trp 
    130                 135                 140                 

Gln Pro Asp Leu Val Met Ala Leu His Val Ala Pro Glu Tyr Pro Ala 
145                 150                 155                 160 

Gly Thr Val Ala Val Lys Lys Gly Leu Leu Phe Ala Asn Thr Ser Glu 
                165                 170                 175     

Leu Tyr Ile Asp Leu Glu Gly Lys Gly Gly His Ala Ala Tyr Pro Gln 
            180                 185                 190         

His Thr Lys Asp Met Val Val Ala Ala Ala His Leu Val Thr Gln Leu 
        195                 200                 205             

Gln Ser Ile Ile Ser Arg Asn Ile Asp Pro Leu Asp Ser Ala Val Val 
    210                 215                 220                 

Thr Ile Gly Lys Ile Thr Gly Gly Thr Val Gln Asn Ala Ile Ala Glu 
225                 230                 235                 240 

His Ala Arg Leu Glu Gly Thr Ile Arg Thr Leu Ser Ser Glu Ala Met 
                245                 250                 255     

Glu Lys Val Lys His Arg Ile Glu Ala Leu Thr Asn Gly Leu Ser Ala 
            260                 265                 270         

Gly Phe Glu Cys Arg Ala Glu Ile Asp Tyr Gly Cys Asn Tyr Tyr Gln 
        275                 280                 285             

Val Phe Asn His Pro Glu Glu Thr Ala Arg Phe Met Asp Phe Val Arg 
    290                 295                 300                 

Ser Tyr Glu Gly Ala His Leu His Glu Cys Arg Glu Ala Leu Thr Gly 
305                 310                 315                 320 

Glu Asp Phe Gly Tyr Met Leu Lys Glu Ile Pro Gly Phe Met Phe Trp 
                325                 330                 335     

Leu Gly Val Gly Ser Pro Tyr Gly Leu His His Ala Lys Phe Ala Pro 
            340                 345                 350         

Asp Glu Arg Ala Leu Glu Thr Ala Ala Asp Leu Met Ile Ala Tyr 
        355                 360                 365         

<210>   76
<211>   376
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   76
Met Met Glu Trp Asp Val Tyr Glu Ala Arg Arg Ala Leu His Gln Ile 
                5                   10                  15      

Pro Glu Pro Gly Phe Arg Glu Phe Glu Thr Gln Lys Leu Val Leu Ser 
            20                  25                  30          

Tyr Leu Gln Ala Leu Pro Gln Glu His Leu Glu Ile Arg Thr Trp Glu 
        35                  40                  45              

Thr Gly Val Ile Ala Leu Val Lys Gly His Ser Pro Lys Arg Arg Val 
    50                  55                  60                  

Gly Trp Arg Ala Asp Met Asp Gly Leu Pro Val Ala Glu Glu Thr Gly 
65                  70                  75                  80  

Val Pro Tyr Ala Ser Arg His Pro Gly Met Met His Ala Cys Gly His 
                85                  90                  95      

Asp Val His Met Ala Val Ala Leu Gly Leu Ala Gln His Phe Ala His 
            100                 105                 110         

Asn Pro Pro Pro Asp Asp Leu Val Leu Val Phe Gln Pro Ala Glu Glu 
        115                 120                 125             

Gly Pro Gly Gly Ala Gln Pro Met Leu Ala Ser Glu Ala Phe Gln Ala 
    130                 135                 140                 

Val Arg Pro Glu Met Ile Phe Ala Leu His Val Gln Pro Asp Met Ala 
145                 150                 155                 160 

Val Gly Glu Ile Gly Ile Arg Pro Gly Val Leu Phe Ala Asn Thr Ser 
                165                 170                 175     

Glu Leu Phe Ile His Leu Val Gly Gln Gly Gly His Ala Ala Tyr Pro 
            180                 185                 190         

His Arg Ala Asn Asp Met Val Val Ala Gly Ala His Leu Val Thr Ala 
        195                 200                 205             

Leu Gln Thr Ile Val Ala Arg Asn Val Asp Pro Leu Asp Ser Ala Val 
    210                 215                 220                 

Ile Thr Val Gly Arg Leu Glu Ser Gly Thr Lys Met Asn Ile Ile Ala 
225                 230                 235                 240 

Glu Arg Ala Arg Leu Glu Gly Thr Val Arg Ala Leu Asn Ala Ala Thr 
                245                 250                 255     

Met Pro Arg Leu Lys Asn Arg Ile Glu Ala Val Val Ala Gly Ile Glu 
            260                 265                 270         

Arg Met Phe Asn Cys Gln Ala Glu Ile Asp Tyr Gly Ala Asn Tyr Tyr 
        275                 280                 285             

Gln Val Tyr Asn Asp Glu Arg Leu Thr Arg Gly Phe Met Gln Phe Val 
    290                 295                 300                 

Glu Glu Ala Gly Leu Ala Asp Val His Glu Val Pro Pro Ala Met Thr 
305                 310                 315                 320 

Gly Glu Asp Phe Gly Tyr Phe Leu Arg Glu Ile Pro Gly Phe Leu Phe 
                325                 330                 335     

Trp Leu Gly Ala Ala Thr Pro Tyr Gly Leu His His Ala Lys Met Leu 
            340                 345                 350         

Pro Asp Glu Arg Cys Ile Asp Ile Ala Leu Arg Val Leu Ile Pro Tyr 
        355                 360                 365             

Phe Ala Glu Arg Arg Tyr Glu Ala 
    370                 375     

<210>   77
<211>   376
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   77
Met Met Glu Trp Asp Val Tyr Glu Ala Arg Arg Ala Leu His Gln Ile 
                5                   10                  15      

Pro Glu Pro Gly Phe Arg Glu Phe Glu Thr Gln Lys Leu Val Leu Ser 
            20                  25                  30          

Tyr Leu Gln Ala Leu Pro Gln Glu His Leu Glu Ile Arg Thr Trp Glu 
        35                  40                  45              

Thr Gly Val Ile Ala Leu Val Lys Gly His Ser Pro Lys Arg Arg Val 
    50                  55                  60                  

Gly Trp Arg Ala Asp Met Asp Gly Leu Pro Val Ala Glu Glu Thr Gly 
65                  70                  75                  80  

Val Pro Tyr Ala Ser Arg His Pro Gly Met Met His Ala Cys Gly His 
                85                  90                  95      

Asp Val His Met Ala Val Ala Leu Gly Leu Ala Gln His Phe Ala His 
            100                 105                 110         

Asn Pro Pro Pro Asp Asp Leu Val Leu Val Phe Gln Pro Ala Glu Glu 
        115                 120                 125             

Gly Pro Gly Gly Ala Gln Pro Met Leu Ala Ser Glu Ala Phe Gln Ala 
    130                 135                 140                 

Val Arg Pro Glu Met Ile Phe Ala Leu His Val Gln Pro Asp Met Ala 
145                 150                 155                 160 

Val Gly Glu Ile Gly Ile Arg Pro Gly Val Leu Phe Ala Asn Thr Ser 
                165                 170                 175     

Glu Leu Phe Ile His Leu Val Gly Gln Gly Gly His Ala Ala Tyr Pro 
            180                 185                 190         

His Arg Ala Asn Asp Met Val Val Ala Gly Ala His Leu Val Thr Ala 
        195                 200                 205             

Leu Gln Thr Ile Val Ala Arg Asn Val Asp Pro Leu Asp Ser Ala Val 
    210                 215                 220                 

Ile Thr Val Gly Arg Leu Glu Ser Gly Thr Lys Met Asn Ile Ile Ala 
225                 230                 235                 240 

Glu Arg Ala Arg Leu Glu Gly Thr Val Arg Ala Leu Asn Ala Ala Thr 
                245                 250                 255     

Met Pro Arg Leu Lys Asn Arg Ile Glu Ala Val Val Ala Gly Ile Glu 
            260                 265                 270         

Arg Met Phe Asn Cys Gln Ala Glu Ile Asp Tyr Gly Ala Asn Tyr Tyr 
        275                 280                 285             

Gln Val Tyr Asn Asp Glu Lys Leu Thr Arg Gly Phe Met Gln Phe Val 
    290                 295                 300                 

Glu Glu Ala Gly Leu Ala Asp Val His Glu Val Pro Pro Ala Met Thr 
305                 310                 315                 320 

Gly Glu Asp Phe Gly Tyr Phe Leu Arg Glu Ile Pro Gly Phe Leu Phe 
                325                 330                 335     

Trp Leu Gly Ala Ala Thr Pro Tyr Gly Leu His His Ala Lys Met Leu 
            340                 345                 350         

Pro Asp Glu Arg Cys Ile Asp Val Ala Leu Arg Val Leu Ile Pro Tyr 
        355                 360                 365             

Phe Ala Glu Arg Arg Tyr Glu Ala 
    370                 375     

<210>   78
<211>   376
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   78
Met Met Glu Trp Asp Val Tyr Glu Ala Arg Arg Ala Leu His Gln Ile 
                5                   10                  15      

Pro Glu Pro Gly Phe Arg Glu Phe Glu Thr Gln Lys Leu Val Leu Ser 
            20                  25                  30          

Tyr Leu Gln Ala Leu Pro Gln Glu His Leu Glu Ile Arg Thr Trp Glu 
        35                  40                  45              

Thr Gly Val Ile Ala Leu Val Lys Gly His Ser Pro Lys Arg Arg Val 
    50                  55                  60                  

Gly Trp Arg Ala Asp Met Asp Gly Leu Pro Val Ala Glu Glu Thr Gly 
65                  70                  75                  80  

Val Pro Tyr Ala Ser Arg His Pro Gly Met Met His Ala Cys Gly His 
                85                  90                  95      

Asp Val His Met Ala Val Ala Leu Gly Leu Ala Gln His Phe Ala His 
            100                 105                 110         

Asn Pro Pro Pro Asp Asp Leu Val Leu Val Phe Gln Pro Ala Glu Glu 
        115                 120                 125             

Gly Pro Gly Gly Ala Gln Pro Met Leu Ala Ser Glu Ala Phe Gln Ala 
    130                 135                 140                 

Val Arg Pro Glu Met Ile Phe Ala Leu His Val Gln Pro Asp Met Ala 
145                 150                 155                 160 

Val Gly Glu Ile Gly Ile Arg Pro Gly Val Leu Phe Ala Asn Thr Ser 
                165                 170                 175     

Glu Leu Phe Ile His Leu Val Gly Gln Gly Gly His Ala Ala Tyr Pro 
            180                 185                 190         

His Arg Ala Asn Asp Met Val Val Ala Gly Ala His Leu Val Thr Ala 
        195                 200                 205             

Leu Gln Thr Ile Val Ala Arg Asn Val Asp Pro Leu Asp Ser Ala Val 
    210                 215                 220                 

Ile Thr Val Gly Arg Leu Glu Ser Gly Thr Lys Met Asn Ile Ile Ala 
225                 230                 235                 240 

Glu Arg Ala Arg Leu Glu Gly Thr Val Arg Ala Leu Asn Ala Ala Thr 
                245                 250                 255     

Met Pro Arg Leu Lys Asn Arg Ile Glu Ala Val Val Ala Gly Ile Glu 
            260                 265                 270         

Arg Met Phe Asn Cys Gln Ala Glu Ile Asp Tyr Gly Ala Asn Tyr Tyr 
        275                 280                 285             

Gln Val Tyr Asn Asp Glu Arg Leu Thr Arg Gly Phe Met Gln Phe Val 
    290                 295                 300                 

Glu Glu Ala Gly Leu Ala Asp Val His Glu Val Pro Pro Ala Met Thr 
305                 310                 315                 320 

Gly Glu Asp Phe Gly Tyr Phe Leu Arg Glu Ile Pro Gly Phe Leu Phe 
                325                 330                 335     

Trp Leu Gly Ala Ala Thr Pro Tyr Gly Leu His His Ala Lys Met Ile 
            340                 345                 350         

Pro Asp Glu Arg Cys Ile Asp Val Ala Leu Arg Val Leu Ile Pro Tyr 
        355                 360                 365             

Phe Ala Glu Arg Arg Tyr Glu Ala 
    370                 375     

<210>   79
<211>   376
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   79
Met Met Glu Trp Asp Val Tyr Glu Ala Arg Arg Ala Leu His Gln Ile 
                5                   10                  15      

Pro Glu Pro Gly Phe Arg Glu Phe Glu Thr Gln Lys Leu Val Leu Ser 
            20                  25                  30          

Tyr Leu Gln Ala Leu Pro Gln Glu His Leu Glu Ile Arg Thr Trp Glu 
        35                  40                  45              

Thr Gly Val Ile Ala Leu Val Lys Gly His Ser Pro Lys Arg Arg Val 
    50                  55                  60                  

Gly Trp Arg Ala Asp Met Asp Gly Leu Pro Val Ala Glu Glu Thr Gly 
65                  70                  75                  80  

Val Pro Tyr Ala Ser Arg His Pro Gly Met Met His Ala Cys Gly His 
                85                  90                  95      

Asp Val His Met Ala Val Ala Leu Gly Leu Ala Gln His Phe Ala His 
            100                 105                 110         

Asn Pro Pro Pro Asp Asp Leu Val Leu Val Phe Gln Pro Ala Glu Glu 
        115                 120                 125             

Gly Pro Gly Gly Ala Gln Pro Met Leu Ala Ser Glu Ala Phe Gln Ala 
    130                 135                 140                 

Val Arg Pro Glu Met Ile Phe Ala Leu His Val Gln Pro Asp Met Ala 
145                 150                 155                 160 

Val Gly Glu Ile Gly Ile Arg Pro Gly Val Leu Phe Ala Asn Thr Ser 
                165                 170                 175     

Glu Leu Phe Ile His Leu Val Gly Gln Gly Gly His Ala Ala Tyr Pro 
            180                 185                 190         

His Arg Ala Asn Asp Met Val Val Ala Gly Ala His Leu Val Thr Ala 
        195                 200                 205             

Leu Gln Thr Ile Val Ala Arg Asn Val Asp Pro Leu Asp Ser Ala Val 
    210                 215                 220                 

Ile Thr Val Gly Arg Leu Glu Ser Gly Thr Lys Met Asn Ile Ile Ala 
225                 230                 235                 240 

Glu Arg Ala Arg Leu Glu Gly Thr Val Arg Ala Leu Asn Ala Ala Thr 
                245                 250                 255     

Met Pro Arg Leu Lys Asn Arg Ile Glu Ala Val Val Ala Gly Ile Glu 
            260                 265                 270         

Arg Met Phe Asn Cys Gln Ala Glu Ile Asp Tyr Gly Ala Asn Tyr Tyr 
        275                 280                 285             

Gln Val Tyr Asn Asp Glu Arg Leu Thr Arg Gly Phe Met Gln Phe Val 
    290                 295                 300                 

Glu Glu Ala Gly Leu Ala Asp Val His Glu Val Pro Pro Ala Met Thr 
305                 310                 315                 320 

Gly Glu Asp Phe Gly Tyr Phe Leu Arg Glu Ile Pro Gly Phe Leu Phe 
                325                 330                 335     

Trp Leu Gly Ala Ala Thr Pro Tyr Gly Leu His His Ala Lys Met Leu 
            340                 345                 350         

Pro Asp Glu Arg Cys Ile Asp Val Ala Leu Arg Val Leu Ile Pro Tyr 
        355                 360                 365             

Phe Ala Glu Arg Lys Tyr Glu Ala 
    370                 375     

<210>   80
<211>   376
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   80
Met Met Glu Trp Asp Val Tyr Glu Ala Arg Arg Ala Leu His Gln Ile 
                5                   10                  15      

Pro Glu Pro Gly Phe Arg Glu Phe Glu Thr Gln Lys Leu Val Leu Ser 
            20                  25                  30          

Tyr Leu Gln Ala Leu Pro Gln Glu His Leu Glu Ile Arg Thr Trp Glu 
        35                  40                  45              

Thr Gly Val Ile Ala Leu Val Lys Gly His Ser Pro Lys Arg Arg Val 
    50                  55                  60                  

Gly Trp Arg Ala Asp Met Asp Gly Leu Pro Val Ala Glu Glu Thr Gly 
65                  70                  75                  80  

Val Pro Tyr Ala Ser Arg His Pro Gly Met Met His Ala Cys Gly His 
                85                  90                  95      

Asp Val His Met Ala Val Ala Leu Gly Leu Ala Gln His Phe Ala His 
            100                 105                 110         

Asn Pro Pro Pro Asp Asp Leu Val Leu Val Phe Gln Pro Ala Glu Glu 
        115                 120                 125             

Gly Pro Gly Gly Ala Gln Pro Met Leu Ala Ser Glu Ala Phe Gln Ala 
    130                 135                 140                 

Val Arg Pro Glu Met Ile Phe Ala Leu His Val Gln Pro Asp Met Ala 
145                 150                 155                 160 

Val Gly Glu Ile Gly Ile Arg Pro Gly Val Leu Phe Ala Asn Thr Ser 
                165                 170                 175     

Glu Leu Phe Ile His Leu Val Gly Gln Gly Gly His Ala Ala Tyr Pro 
            180                 185                 190         

His Arg Ala Asn Asp Met Val Val Ala Gly Ala His Leu Val Thr Ala 
        195                 200                 205             

Leu Gln Thr Ile Val Ala Arg Asn Val Asp Pro Leu Asp Ser Ala Val 
    210                 215                 220                 

Ile Thr Val Gly Arg Leu Glu Ser Gly Thr Lys Met Asn Ile Ile Ala 
225                 230                 235                 240 

Glu Arg Ala Arg Leu Glu Gly Thr Val Arg Ala Leu Asn Ala Ala Thr 
                245                 250                 255     

Met Pro Arg Leu Lys Asn Arg Ile Glu Ala Val Val Ala Gly Ile Glu 
            260                 265                 270         

Arg Met Phe Asn Cys Gln Ala Glu Ile Asp Tyr Gly Ala Asn Tyr Tyr 
        275                 280                 285             

Gln Val Tyr Asn Asp Glu Arg Leu Thr Arg Gly Phe Met Gln Phe Val 
    290                 295                 300                 

Asp Glu Ala Gly Leu Ala Asp Val His Glu Val Pro Pro Ala Met Thr 
305                 310                 315                 320 

Gly Glu Asp Phe Gly Tyr Phe Leu Arg Glu Ile Pro Gly Phe Leu Phe 
                325                 330                 335     

Trp Leu Gly Ala Ala Thr Pro Tyr Gly Leu His His Ala Lys Met Leu 
            340                 345                 350         

Pro Asp Glu Arg Cys Ile Asp Val Ala Leu Arg Val Leu Ile Pro Tyr 
        355                 360                 365             

Phe Ala Glu Arg Arg Tyr Glu Ala 
    370                 375     

<210>   81
<211>   1131
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   81
gtgatggagt gggatgtgta cgaagcgcgg cgcgccctgc accaaattcc agagcccgga       60

tttcgggagt ttgagacgca gaaactggtg ctctcgtatc tgcaggcgct cccacaggag      120

cacctggaga tccgcacgtg ggagacgggc gtgattgcgc tcgtgaaggg acacagtccg      180

aagcgacgcg tgggctggcg cgcggacatg gacgggctgc ccgtggcgga ggagacgggc      240

gtcccgtatg cgtcgcgcca tccgggcatg atgcacgcct gcgggcacga cgtgcacatg      300

gccgtcgcgc tcggcctcgc tcagcacttc gcccacaacc ctccgccgga cgatctcgtc      360

ctcgtctttc agcccgccga ggagggcccg ggcggcgcac agccgatgct cgcgagcgag      420

gcgtttcagg ccgtgcggcc tgagatgatc ttcgcactgc acgtgcagcc cgacatggct      480

gtaggcgaga ttggcatccg gcccggcgtg ctgtttgcga acacgtccga gctgttcatc      540

catctcgtcg gccaaggagg gcacgcggcc tatccgcacc gggccaacga catggtggtg      600

gcgggtgcac acctcgtgac ggcgctgcag accatcgtgg cgcgaaatgt ggatccgtta      660

gacagcgcgg tcatcaccgt ggggcggctg gagtcgggca cgaagatgaa tatcatcgcg      720

gagcgcgcgc gcctcgaggg cactgtccgg gcactcaacg cggccaccat gccccgcctc      780

aagaaccgaa ttgaggcggt ggtggcaggg attgagcgga tgttcaactg ccaggccgag      840

atcgactacg gcgcgaatta ctaccaggtg tacaacgacg agcgcctcac ccgcgggttc      900

atgcagtttg tcgaggaggc cgggctcgcc gacgtgcacg aggttccgcc cgccatgacg      960

ggcgaggatt tcggctactt tctgcgcgaa atcccgggtt ttctgttctg gctcggcgcg     1020

gccacgccgt acggcctgca ccacgccaag atgctcccgg acgagcgatg catcgacatt     1080

gcgctgcgcg tgctcatccc gtacttcgcc gagcggcgat acgaggcttg a              1131


<210>   82
<211>   1131
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   82
gtgatggagt gggatgtgta cgaagcgcgg cgcgccctgc accaaattcc agagcccgga       60

tttcgggagt ttgagacgca gaaactggtg ctctcgtatc tgcaggcgct cccacaggag      120

cacctggaga tccgcacgtg ggagacgggc gtgattgcgc tcgtgaaggg acacagtccg      180

aagcgacgcg tgggctggcg cgcggacatg gacgggctgc ccgtggcgga ggagacgggc      240

gtcccgtatg cgtcgcgcca tccgggcatg atgcacgcct gcgggcacga cgtgcacatg      300

gccgtcgcgc tcggcctcgc tcagcacttc gcccacaacc ctccgccgga cgatctcgtc      360

ctcgtctttc agcccgccga ggagggcccg ggcggcgcac agccgatgct cgcgagcgag      420

gcgtttcagg ccgtgcggcc tgagatgatc ttcgcactgc acgtgcagcc cgacatggct      480

gtaggcgaga ttggcatccg gcccggcgtg ctgtttgcga acacgtccga gctgttcatc      540

catctcgtcg gccaaggagg gcacgcggcc tatccgcacc gggccaacga catggtggtg      600

gcgggtgcac acctcgtgac ggcgctgcag accatcgtgg cgcgaaatgt ggatccgtta      660

gacagcgcgg tcatcaccgt ggggcggctg gagtcgggca cgaagatgaa tatcatcgcg      720

gagcgcgcgc gcctcgaggg cactgtccgg gcactcaacg cggccaccat gccccgcctc      780

aagaaccgaa ttgaggcggt ggtggcaggg attgagcgga tgttcaactg ccaggccgag      840

atcgactacg gcgcgaatta ctaccaggtg tacaacgacg agaaactcac ccgcgggttc      900

atgcagtttg tcgaggaggc cgggctcgcc gacgtgcacg aggttccgcc cgccatgacg      960

ggcgaggatt tcggctactt tctgcgcgaa atcccgggtt ttctgttctg gctcggcgcg     1020

gccacgccgt acggcctgca ccacgccaag atgctcccgg acgagcgatg catcgacgtg     1080

gcgctgcgcg tgctcatccc gtacttcgcc gagcggcgat acgaggcttg a              1131


<210>   83
<211>   1131
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   83
gtgatggagt gggatgtgta cgaagcgcgg cgcgccctgc accaaattcc agagcccgga       60

tttcgggagt ttgagacgca gaaactggtg ctctcgtatc tgcaggcgct cccacaggag      120

cacctggaga tccgcacgtg ggagacgggc gtgattgcgc tcgtgaaggg acacagtccg      180

aagcgacgcg tgggctggcg cgcggacatg gacgggctgc ccgtggcgga ggagacgggc      240

gtcccgtatg cgtcgcgcca tccgggcatg atgcacgcct gcgggcacga cgtgcacatg      300

gccgtcgcgc tcggcctcgc tcagcacttc gcccacaacc ctccgccgga cgatctcgtc      360

ctcgtctttc agcccgccga ggagggcccg ggcggcgcac agccgatgct cgcgagcgag      420

gcgtttcagg ccgtgcggcc tgagatgatc ttcgcactgc acgtgcagcc cgacatggct      480

gtaggcgaga ttggcatccg gcccggcgtg ctgtttgcga acacgtccga gctgttcatc      540

catctcgtcg gccaaggagg gcacgcggcc tatccgcacc gggccaacga catggtggtg      600

gcgggtgcac acctcgtgac ggcgctgcag accatcgtgg cgcgaaatgt ggatccgtta      660

gacagcgcgg tcatcaccgt ggggcggctg gagtcgggca cgaagatgaa tatcatcgcg      720

gagcgcgcgc gcctcgaggg cactgtccgg gcactcaacg cggccaccat gccccgcctc      780

aagaaccgaa ttgaggcggt ggtggcaggg attgagcgga tgttcaactg ccaggccgag      840

atcgactacg gcgcgaatta ctaccaggtg tacaacgacg agcgcctcac ccgcgggttc      900

atgcagtttg tcgaggaggc cgggctcgcc gacgtgcacg aggttccgcc cgccatgacg      960

ggcgaggatt tcggctactt tctgcgcgaa atcccgggtt ttctgttctg gctcggcgcg     1020

gccacgccgt acggcctgca ccacgccaag atgattccgg acgagcgatg catcgacgtg     1080

gcgctgcgcg tgctcatccc gtacttcgcc gagcggcgat acgaggcttg a              1131


<210>   84
<211>   1131
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   84
gtgatggagt gggatgtgta cgaagcgcgg cgcgccctgc accaaattcc agagcccgga       60

tttcgggagt ttgagacgca gaaactggtg ctctcgtatc tgcaggcgct cccacaggag      120

cacctggaga tccgcacgtg ggagacgggc gtgattgcgc tcgtgaaggg acacagtccg      180

aagcgacgcg tgggctggcg cgcggacatg gacgggctgc ccgtggcgga ggagacgggc      240

gtcccgtatg cgtcgcgcca tccgggcatg atgcacgcct gcgggcacga cgtgcacatg      300

gccgtcgcgc tcggcctcgc tcagcacttc gcccacaacc ctccgccgga cgatctcgtc      360

ctcgtctttc agcccgccga ggagggcccg ggcggcgcac agccgatgct cgcgagcgag      420

gcgtttcagg ccgtgcggcc tgagatgatc ttcgcactgc acgtgcagcc cgacatggct      480

gtaggcgaga ttggcatccg gcccggcgtg ctgtttgcga acacgtccga gctgttcatc      540

catctcgtcg gccaaggagg gcacgcggcc tatccgcacc gggccaacga catggtggtg      600

gcgggtgcac acctcgtgac ggcgctgcag accatcgtgg cgcgaaatgt ggatccgtta      660

gacagcgcgg tcatcaccgt ggggcggctg gagtcgggca cgaagatgaa tatcatcgcg      720

gagcgcgcgc gcctcgaggg cactgtccgg gcactcaacg cggccaccat gccccgcctc      780

aagaaccgaa ttgaggcggt ggtggcaggg attgagcgga tgttcaactg ccaggccgag      840

atcgactacg gcgcgaatta ctaccaggtg tacaacgacg agcgcctcac ccgcgggttc      900

atgcagtttg tcgaggaggc cgggctcgcc gacgtgcacg aggttccgcc cgccatgacg      960

ggcgaggatt tcggctactt tctgcgcgaa atcccgggtt ttctgttctg gctcggcgcg     1020

gccacgccgt acggcctgca ccacgccaag atgctcccgg acgagcgatg catcgacgtg     1080

gcgctgcgcg tgctcatccc gtacttcgcc gagcggaaat acgaggcttg a              1131


<210>   85
<211>   1131
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   85
gtgatggagt gggatgtgta cgaagcgcgg cgcgccctgc accaaattcc agagcccgga       60

tttcgggagt ttgagacgca gaaactggtg ctctcgtatc tgcaggcgct cccacaggag      120

cacctggaga tccgcacgtg ggagacgggc gtgattgcgc tcgtgaaggg acacagtccg      180

aagcgacgcg tgggctggcg cgcggacatg gacgggctgc ccgtggcgga ggagacgggc      240

gtcccgtatg cgtcgcgcca tccgggcatg atgcacgcct gcgggcacga cgtgcacatg      300

gccgtcgcgc tcggcctcgc tcagcacttc gcccacaacc ctccgccgga cgatctcgtc      360

ctcgtctttc agcccgccga ggagggcccg ggcggcgcac agccgatgct cgcgagcgag      420

gcgtttcagg ccgtgcggcc tgagatgatc ttcgcactgc acgtgcagcc cgacatggct      480

gtaggcgaga ttggcatccg gcccggcgtg ctgtttgcga acacgtccga gctgttcatc      540

catctcgtcg gccaaggagg gcacgcggcc tatccgcacc gggccaacga catggtggtg      600

gcgggtgcac acctcgtgac ggcgctgcag accatcgtgg cgcgaaatgt ggatccgtta      660

gacagcgcgg tcatcaccgt ggggcggctg gagtcgggca cgaagatgaa tatcatcgcg      720

gagcgcgcgc gcctcgaggg cactgtccgg gcactcaacg cggccaccat gccccgcctc      780

aagaaccgaa ttgaggcggt ggtggcaggg attgagcgga tgttcaactg ccaggccgag      840

atcgactacg gcgcgaatta ctaccaggtg tacaacgacg agcgcctcac ccgcgggttc      900

atgcagtttg tcgatgaggc cgggctcgcc gacgtgcacg aggttccgcc cgccatgacg      960

ggcgaggatt tcggctactt tctgcgcgaa atcccgggtt ttctgttctg gctcggcgcg     1020

gccacgccgt acggcctgca ccacgccaag atgctcccgg acgagcgatg catcgacgtg     1080

gcgctgcgcg tgctcatccc gtacttcgcc gagcggcgat acgaggcttg a              1131


<210>   86
<211>   339
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   86
Met His Glu Gly Ala Leu Thr Met Met Lys Ile Asp Tyr Gln Thr Asn 
                5                   10                  15      

Trp Ile Asp Leu Ala Arg Arg Val Leu Asp Gly Arg Gly Val Thr Arg 
            20                  25                  30          

Glu Glu Ala Leu Asp Ile Leu Arg Ser Ser Asp Asp Glu Leu Leu Asp 
        35                  40                  45              

Leu Leu Ala Ala Ala Phe Leu Ile Arg Arg Arg Tyr Phe Gly Lys Lys 
    50                  55                  60                  

Val Lys Leu Asn Met Ile Ile Asn Ala Lys Ser Lys Met Cys Pro Glu 
65                  70                  75                  80  

Asp Cys Ala Tyr Cys Ser Gln Ser Ala Ile Ser Lys Ala Pro Val Ser 
                85                  90                  95      

Lys Tyr Pro Leu Val Ser Lys Glu Glu Ile Ile Ala Gly Ala Arg Glu 
            100                 105                 110         

Ala Glu Arg Arg Lys Ala Gly Thr Tyr Cys Ile Val Ile Ser Gly Arg 
        115                 120                 125             

Arg Pro Ser Asp Arg Glu Ile Glu Arg Ile Ala Glu Ala Val Glu Glu 
    130                 135                 140                 

Ile Arg Ala Thr Thr Thr Leu Lys Ile Cys Cys Cys Leu Gly Leu Leu 
145                 150                 155                 160 

Thr Pro Ala Gln Ala Asp Arg Leu Ala Arg Ala Gly Val His Arg Tyr 
                165                 170                 175     

Asn His Asn Leu Asn Thr Ser Arg Asp Arg Tyr Gly Asp Ile Cys Thr 
            180                 185                 190         

Thr His Thr Tyr Asp Asp Arg Val Arg Thr Leu Glu His Val Lys Glu 
        195                 200                 205             

Ala Gly Ile Ser Pro Cys Ser Gly Val Ile Phe Gly Met Gly Glu Ser 
    210                 215                 220                 

Asp Glu Glu Ala Val Asp Met Ala Phe Ala Leu Lys Glu Met Asp Ala 
225                 230                 235                 240 

Asp Ser Ile Pro Cys Asn Phe Leu Asn Pro Ile Pro Gly Thr Pro Leu 
                245                 250                 255     

Glu Gly Met Glu Thr Leu Asn Pro Arg Arg Cys Leu Lys Leu Leu Cys 
            260                 265                 270         

Met Met Arg Phe Val Asn Pro Ser Lys Glu Ile Arg Ile Ala Gly Gly 
        275                 280                 285             

Arg Glu Arg Asn Leu Arg Ser Leu Gln Val Leu Gly Leu Tyr Pro Ala 
    290                 295                 300                 

Asn Ser Ile Phe Val Gly Asp Tyr Leu Thr Thr Pro Gly Gln Ala Pro 
305                 310                 315                 320 

Thr Glu Asp Trp Ala Met Ile Glu Asp Leu Gly Phe Glu Ile Glu Glu 
                325                 330                 335     

Cys Ala Leu 
            

<210>   87
<211>   1020
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   87
gtgcacgagg gggcattgac catgatgaaa atcgattatc agaccaattg gattgacctc       60

gcccgtcgcg tccttgatgg gcgcggcgtg actcgcgagg aagccctcga cattctgcgg      120

tcgagcgacg acgaactcct agatctcctc gccgccgcct tcttgattcg caggcgctac      180

ttcggtaaga aggtcaagct caacatgatc atcaacgcca agtcgaagat gtgccccgaa      240

gactgcgcgt actgctccca gtccgccatc tcaaaggccc cggtgtccaa gtatccgctg      300

gtctccaaag aggaaatcat cgccggcgcg cgcgaagccg agcgtcgcaa ggccggcacg      360

tattgcatcg tcatcagcgg aaggcggccg tcggatcggg agattgagcg catcgccgag      420

gccgtggagg aaatccgcgc caccacaacc ctcaagatct gctgctgcct cgggctcttg      480

acgcccgccc aggcggatcg gctcgcccgg gccggcgtgc accggtacaa tcacaacttg      540

aacacgagcc gagatcgata tggcgacatt tgcaccaccc acacctacga cgatcgcgtc      600

cggaccctgg agcacgtgaa agaggcgggc atctcgccgt gttcgggggt catcttcggc      660

atgggcgaat cggacgagga ggcggtggac atggcgtttg cgctgaagga gatggacgcc      720

gactccatcc cgtgcaactt tctgaatccc atcccaggca cgccgctcga aggcatggag      780

accttgaacc cgcggcggtg cctgaagctg ctctgcatga tgcgcttcgt gaatccgtcg      840

aaggagatcc gcatcgcagg cgggcgagag cgaaacctgc gcagcctgca ggtgctcggc      900

ctctacccgg ccaactccat cttcgtcggg gactacttga cgacgcccgg gcaggcgccg      960

acggaggact gggccatgat cgaagacctc gggtttgaga ttgaagaatg cgcgctgtga     1020


<210>   88
<211>   332
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   88
Met Lys Gln Ile Gln Thr Lys Val Asp Trp Lys Lys Ile Ala Phe Glu 
                5                   10                  15      

Gly Ile Glu Gly Lys Arg Ile Thr Lys Glu Asp Ala Leu Ala Ile Leu 
            20                  25                  30          

Glu Ala Asp Asp Thr Glu Val Leu Glu Ile Met Asn Ala Ala Tyr Met 
        35                  40                  45              

Ile Arg His His Tyr Phe Gly Lys Lys Val Lys Leu Asn Met Ile Ile 
    50                  55                  60                  

Asn Thr Lys Ser Gly Leu Cys Pro Glu Asp Cys Gly Tyr Cys Ser Gln 
65                  70                  75                  80  

Ser Ile Val Ser Glu Ala Pro Ile Asp Lys Tyr Ala Trp Leu Thr Gln 
                85                  90                  95      

Glu Lys Ile Val Glu Gly Ala His Glu Ala Val Arg Arg Lys Ala Gly 
            100                 105                 110         

Thr Tyr Cys Ile Val Ala Ser Gly Arg Arg Pro Thr Asp Lys Glu Val 
        115                 120                 125             

Asn His Val Ile Gly Ala Val Lys Glu Ile Lys Glu Thr Thr Asp Leu 
    130                 135                 140                 

Lys Ile Cys Cys Cys Leu Gly Phe Leu Asn Glu Asp Gln Ala Lys Arg 
145                 150                 155                 160 

Leu Ala Glu Ala Gly Val His Arg Tyr Asn His Asn Leu Asn Thr His 
                165                 170                 175     

Ala Asn His Tyr Asp Asn Ile Cys Ser Thr His Thr Tyr Asp Asp Arg 
            180                 185                 190         

Val Asp Thr Val Glu Lys Val Lys Gln Ala Gly Ile Ser Pro Cys Ser 
        195                 200                 205             

Gly Ala Ile Phe Gly Met Gly Glu Thr Lys Glu Glu Arg Val Glu Ile 
    210                 215                 220                 

Ala Phe Glu Leu Gln Arg Leu Asp Ala Asp Ser Ile Pro Cys Asn Phe 
225                 230                 235                 240 

Leu Val Ser Val Lys Gly Thr Pro Phe Glu Gly Arg Lys Glu Leu Thr 
                245                 250                 255     

Pro Val Glu Cys Leu Lys Ile Leu Ala Met Met Arg Phe Val Asn Pro 
            260                 265                 270         

Ser Lys Glu Ile Arg Ile Ser Gly Gly Arg Glu Leu Asn Leu Arg Ser 
        275                 280                 285             

Val Gln Pro Leu Gly Leu Phe Ala Ala Asn Ser Ile Phe Val Gly Asp 
    290                 295                 300                 

Tyr Leu Thr Thr Val Gly Gln Glu Ser Thr Ala Asp Trp Glu Met Ile 
305                 310                 315                 320 

Gln Asp Leu Gly Phe Glu Ile Glu Glu Cys Ala Leu 
                325                 330         

<210>   89
<211>   332
<212>   PRT
<213>   Kurthia sp. 538-KA26

<400>   89
Gly Leu Glu Thr Leu Val Lys Lys Asp Trp Lys Met Leu Ala Glu Asn 
                5                   10                  15      

Val Ile Lys Gly Tyr Lys Val Thr Ala Glu Glu Ala Leu Ala Ile Val 
            20                  25                  30          

Gln Ala Pro Asp Asn Glu Val Leu Glu Ile Leu Asn Ala Ala Phe Leu 
        35                  40                  45              

Ile Arg Gln His Tyr Tyr Gly Lys Lys Val Lys Leu Asn Met Ile Ile 
    50                  55                  60                  

Asn Thr Lys Ser Gly Leu Cys Pro Glu Asp Cys Gly Tyr Cys Ser Gln 
65                  70                  75                  80  

Ser Ile Val Ser Glu Ala Pro Ile Asp Lys Tyr Ala Trp Leu Thr Lys 
                85                  90                  95      

Glu Lys Ile Val Glu Gly Ala Gln Glu Ser Ile Arg Arg Lys Ala Gly 
            100                 105                 110         

Thr Tyr Cys Ile Val Ala Ser Gly Arg Arg Pro Thr Asn Arg Glu Ile 
        115                 120                 125             

Asp His Val Ile Glu Ala Val Lys Glu Ile Arg Glu Thr Thr Asp Leu 
    130                 135                 140                 

Lys Ile Cys Cys Cys Leu Gly Phe Leu Asn Glu Thr His Ala Ser Lys 
145                 150                 155                 160 

Leu Ala Glu Ala Gly Val His Arg Tyr Lys His Asn Leu Asn Thr Ser 
                165                 170                 175     

Gln Asp Asn Tyr Lys Asn Ile Thr Ser Thr His Thr Tyr Glu Asp Arg 
            180                 185                 190         

Val Asp Thr Val Glu Ala Val Lys Glu Ala Gly Met Ser Pro Cys Ser 
        195                 200                 205             

Gly Ala Ile Phe Gly Met Asn Glu Ser Asn Glu Glu Ala Val Glu Ile 
    210                 215                 220                 

Ala Leu Ser Leu Arg Ser Leu Asp Ala Asp Ser Ile Pro Cys Asn Phe 
225                 230                 235                 240 

Leu Asn Ala Ile Asp Gly Thr Pro Leu Glu Gly Thr Ser Glu Leu Thr 
                245                 250                 255     

Pro Thr Lys Cys Leu Lys Leu Ile Ser Met Met Arg Phe Val Asn Pro 
            260                 265                 270         

Ser Lys Glu Ile Arg Leu Ala Gly Gly Arg Glu Val Asn Leu Arg Ser 
        275                 280                 285             

Met Gln Pro Met Ala Leu Tyr Ala Ala Asn Ser Ile Phe Val Gly Asp 
    290                 295                 300                 

Tyr Leu Thr Thr Ala Gly Gln Glu Pro Thr Ala Asp Trp Gly Ile Ile 
305                 310                 315                 320 

Glu Asp Leu Gly Phe Glu Ile Glu Glu Cys Ala Leu 
                325                 330         

<210>   90
<211>   332
<212>   PRT
<213>   Bacillus anthracis str. Ames

<400>   90
Met Lys Gln Val Gln Thr Lys Arg Asp Trp Lys Lys Leu Ala Tyr Asp 
                5                   10                  15      

Val Val Glu Glu Lys Met Ile Thr Lys Glu Asp Ala Ile Ala Ile Leu 
            20                  25                  30          

Glu Ala Asp Asp Thr Glu Val Leu Glu Ile Met Asn Ala Ala Tyr Ile 
        35                  40                  45              

Ile Arg His His Tyr Phe Gly Lys Lys Val Lys Leu Asn Met Ile Ile 
    50                  55                  60                  

Asn Thr Lys Ser Gly Leu Cys Pro Glu Asp Cys Gly Tyr Cys Ser Gln 
65                  70                  75                  80  

Ser Ile Ile Ser Glu Ala Pro Ile Asp Lys Tyr Ala Trp Leu Thr Gln 
                85                  90                  95      

Glu Lys Ile Val Glu Gly Ala His Glu Ala Ile Arg Arg Lys Ala Gly 
            100                 105                 110         

Thr Tyr Cys Ile Val Ala Ser Gly Arg Arg Pro Thr Asp Lys Glu Val 
        115                 120                 125             

Asn His Val Ile Gly Ala Val Lys Glu Ile Arg Glu Thr Thr Asp Leu 
    130                 135                 140                 

Lys Ile Cys Cys Cys Leu Gly Phe Leu Asn Glu Asp Gln Ala Gly Arg 
145                 150                 155                 160 

Leu Ala Glu Ala Gly Val His Arg Tyr Asn His Asn Leu Asn Thr His 
                165                 170                 175     

Ala Asn Asn Tyr Glu Ser Ile Cys Ser Thr His Thr Tyr Asp Asp Arg 
            180                 185                 190         

Val Asp Thr Val Gln Lys Ala Lys Gln Ala Gly Ile Ser Pro Cys Ser 
        195                 200                 205             

Gly Ala Ile Phe Gly Met Gly Glu Thr Ile Glu Glu Arg Ala Glu Ile 
    210                 215                 220                 

Ala Phe Glu Leu Gln Arg Ile Asp Ala Asp Ser Ile Pro Cys Asn Phe 
225                 230                 235                 240 

Leu Val Ala Val Lys Gly Thr Pro Leu Glu Gly Gln Lys Glu Leu Thr 
                245                 250                 255     

Pro Val Glu Cys Leu Lys Val Leu Ala Met Met Arg Phe Val Asn Pro 
            260                 265                 270         

Thr Lys Glu Ile Arg Ile Ser Gly Gly Arg Glu Ile Asn Leu Arg Ser 
        275                 280                 285             

Val Gln Pro Ile Gly Leu Phe Ala Ala Asn Ser Ile Phe Val Gly Asp 
    290                 295                 300                 

Tyr Leu Thr Thr Ala Gly Gln Glu Pro Thr Ala Asp Trp Gly Met Ile 
305                 310                 315                 320 

Glu Asp Leu Gly Phe Glu Ile Glu Glu Cys Ala Leu 
                325                 330         

<210>   91
<211>   332
<212>   PRT
<213>   Bacillus thuringiensis str. Al Hakam

<400>   91
Met Lys Gln Val Gln Thr Lys Arg Asp Trp Lys Lys Leu Ala Tyr Asp 
                5                   10                  15      

Val Val Glu Glu Lys Met Ile Ala Lys Glu Asp Ala Ile Ala Ile Leu 
            20                  25                  30          

Glu Ala Glu Asp Thr Glu Val Leu Glu Ile Met Asn Ala Ala Tyr Ile 
        35                  40                  45              

Ile Arg His His Tyr Phe Gly Lys Lys Val Lys Leu Asn Met Ile Ile 
    50                  55                  60                  

Asn Thr Lys Ser Gly Leu Cys Pro Glu Asp Cys Gly Tyr Cys Ser Gln 
65                  70                  75                  80  

Ser Ile Ile Ser Glu Ala Pro Ile Asp Lys Tyr Ala Trp Leu Thr Gln 
                85                  90                  95      

Glu Lys Ile Val Glu Gly Ala His Glu Ala Ile Arg Arg Lys Ala Gly 
            100                 105                 110         

Thr Tyr Cys Ile Val Ala Ser Gly Arg Arg Pro Thr Asp Lys Glu Val 
        115                 120                 125             

Asn His Val Ile Gly Ala Val Lys Glu Ile Arg Glu Thr Thr Asp Leu 
    130                 135                 140                 

Lys Ile Cys Cys Cys Leu Gly Phe Leu Asn Glu Asp Gln Ala Gly Arg 
145                 150                 155                 160 

Leu Ala Glu Ala Gly Val His Arg Tyr Asn His Asn Leu Asn Thr His 
                165                 170                 175     

Ala Asn Asn Tyr Glu Asn Ile Cys Ser Thr His Thr Tyr Asp Asp Arg 
            180                 185                 190         

Val Asp Thr Val Gln Lys Ala Lys Gln Ala Gly Ile Ser Pro Cys Ser 
        195                 200                 205             

Gly Ala Ile Phe Gly Met Gly Glu Thr Ile Glu Glu Arg Ala Glu Ile 
    210                 215                 220                 

Ala Phe Glu Leu Gln Arg Ile Asp Ala Asp Ser Ile Pro Cys Asn Phe 
225                 230                 235                 240 

Leu Val Ala Val Lys Gly Thr Pro Leu Glu Gly Gln Lys Glu Leu Thr 
                245                 250                 255     

Pro Val Glu Cys Leu Lys Val Leu Ala Met Met Arg Phe Val Asn Pro 
            260                 265                 270         

Thr Lys Glu Ile Arg Ile Ser Gly Gly Arg Glu Ile Asn Leu Arg Ser 
        275                 280                 285             

Val Gln Pro Ile Gly Leu Phe Ala Ala Asn Ser Ile Phe Val Gly Asp 
    290                 295                 300                 

Tyr Leu Thr Thr Ala Gly Gln Glu Pro Thr Ala Asp Trp Gly Met Ile 
305                 310                 315                 320 

Glu Asp Leu Gly Phe Glu Ile Glu Glu Cys Ala Leu 
                325                 330         

<210>   92
<211>   332
<212>   PRT
<213>   Bacillus cereus G9241

<400>   92
Met Lys Gln Val Gln Thr Lys Arg Asp Trp Lys Lys Leu Ala Tyr Asp 
                5                   10                  15      

Val Val Glu Glu Lys Met Ile Thr Lys Glu Asp Ala Ile Ala Ile Leu 
            20                  25                  30          

Glu Ala Asp Glu Thr Glu Val Leu Glu Ile Met Asn Ala Ala Tyr Ile 
        35                  40                  45              

Ile Arg His His His Phe Gly Lys Lys Val Lys Leu Asn Met Ile Ile 
    50                  55                  60                  

Asn Thr Lys Ser Gly Leu Cys Pro Glu Asp Cys Gly Tyr Cys Ser Gln 
65                  70                  75                  80  

Ser Ile Ile Ser Glu Ala Pro Ile Asp Lys Tyr Ala Trp Leu Thr Gln 
                85                  90                  95      

Glu Lys Ile Val Glu Gly Ala His Glu Ala Ile Arg Arg Lys Ala Gly 
            100                 105                 110         

Thr Tyr Cys Ile Val Ala Ser Gly Arg Arg Pro Thr Asp Lys Glu Val 
        115                 120                 125             

Asn His Val Ile Gly Ala Val Lys Glu Ile Arg Glu Thr Thr Asp Leu 
    130                 135                 140                 

Lys Ile Cys Cys Cys Leu Gly Phe Leu Asn Glu Asp Gln Ala Gly Arg 
145                 150                 155                 160 

Leu Ala Glu Ala Gly Val His Arg Tyr Asn His Asn Leu Asn Thr His 
                165                 170                 175     

Ala Asn Asn Tyr Glu Ser Ile Cys Ser Thr His Thr Tyr Asp Asp Arg 
            180                 185                 190         

Val Asp Thr Val Gln Lys Ala Lys Gln Ala Gly Ile Ser Pro Cys Ser 
        195                 200                 205             

Gly Ala Ile Phe Gly Met Gly Glu Thr Ile Glu Glu Arg Ala Glu Ile 
    210                 215                 220                 

Ala Phe Glu Leu Gln Arg Ile Asp Ala Asp Ser Ile Pro Cys Asn Phe 
225                 230                 235                 240 

Leu Val Ala Val Lys Gly Thr Pro Leu Glu Gly Gln Lys Glu Leu Thr 
                245                 250                 255     

Pro Val Glu Cys Leu Lys Val Leu Ala Met Met Arg Phe Val Asn Pro 
            260                 265                 270         

Thr Lys Glu Ile Arg Ile Ser Gly Gly Arg Glu Ile Asn Leu Arg Ser 
        275                 280                 285             

Val Gln Pro Ile Gly Leu Phe Ala Ala Asn Ser Ile Phe Val Gly Asp 
    290                 295                 300                 

Tyr Leu Thr Thr Ala Gly Gln Glu Pro Thr Ala Asp Trp Gly Met Ile 
305                 310                 315                 320 

Glu Asp Leu Gly Phe Glu Ile Glu Glu Cys Ala Leu 
                325                 330         

<210>   93
<211>   339
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   93
Met His Glu Gly Ala Leu Thr Met Met Lys Ile Asp Tyr Gln Thr Asn 
                5                   10                  15      

Trp Ile Asp Leu Ala Lys Arg Val Leu Asp Gly Arg Gly Val Thr Arg 
            20                  25                  30          

Glu Glu Ala Leu Asp Ile Leu Arg Ser Ser Asp Asp Glu Leu Leu Asp 
        35                  40                  45              

Leu Leu Ala Ala Ala Phe Leu Ile Arg Arg Arg Tyr Phe Gly Lys Lys 
    50                  55                  60                  

Val Lys Leu Asn Met Ile Ile Asn Ala Lys Ser Lys Met Cys Pro Glu 
65                  70                  75                  80  

Asp Cys Ala Tyr Cys Ser Gln Ser Ala Ile Ser Lys Ala Pro Val Ser 
                85                  90                  95      

Lys Tyr Pro Leu Val Ser Lys Glu Glu Ile Ile Ala Gly Ala Arg Glu 
            100                 105                 110         

Ala Glu Arg Arg Lys Ala Gly Thr Tyr Cys Ile Val Ile Ser Gly Arg 
        115                 120                 125             

Arg Pro Ser Asp Arg Glu Ile Glu Arg Ile Ala Glu Ala Val Glu Glu 
    130                 135                 140                 

Ile Arg Ala Thr Thr Thr Leu Lys Ile Cys Cys Cys Leu Gly Leu Leu 
145                 150                 155                 160 

Thr Pro Ala Gln Ala Asp Arg Leu Ala Arg Ala Gly Val His Arg Tyr 
                165                 170                 175     

Asn His Asn Leu Asn Thr Ser Arg Asp Arg Tyr Gly Asp Ile Cys Thr 
            180                 185                 190         

Thr His Thr Tyr Asp Asp Arg Val Arg Thr Leu Glu His Val Lys Glu 
        195                 200                 205             

Ala Gly Ile Ser Pro Cys Ser Gly Val Ile Phe Gly Met Gly Glu Ser 
    210                 215                 220                 

Asp Glu Glu Ala Val Asp Met Ala Phe Ala Leu Lys Glu Met Asp Ala 
225                 230                 235                 240 

Asp Ser Ile Pro Cys Asn Phe Leu Asn Pro Ile Pro Gly Thr Pro Leu 
                245                 250                 255     

Glu Gly Met Glu Thr Leu Asn Pro Arg Arg Cys Leu Lys Leu Leu Cys 
            260                 265                 270         

Met Met Arg Phe Val Asn Pro Ser Lys Glu Ile Arg Ile Ala Gly Gly 
        275                 280                 285             

Arg Glu Arg Asn Leu Arg Ser Leu Gln Val Leu Gly Leu Tyr Pro Ala 
    290                 295                 300                 

Asn Ser Ile Phe Val Gly Asp Tyr Leu Thr Thr Pro Gly Gln Ala Pro 
305                 310                 315                 320 

Thr Glu Asp Trp Ala Met Ile Glu Asp Leu Gly Phe Glu Ile Glu Glu 
                325                 330                 335     

Cys Ala Leu 
            

<210>   94
<211>   339
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   94
Met His Glu Gly Ala Leu Thr Met Met Lys Ile Asp Tyr Gln Thr Asn 
                5                   10                  15      

Trp Ile Asp Leu Ala Arg Arg Val Leu Asp Gly Arg Gly Val Thr Arg 
            20                  25                  30          

Glu Glu Ala Leu Asp Ile Leu Arg Ser Ser Asp Asp Glu Leu Leu Asp 
        35                  40                  45              

Leu Leu Ala Ala Ala Phe Leu Ile Arg Arg Arg Tyr Phe Gly Lys Lys 
    50                  55                  60                  

Val Lys Leu Asn Met Ile Ile Asn Ala Lys Ser Lys Met Cys Pro Glu 
65                  70                  75                  80  

Asp Cys Ala Tyr Cys Ser Gln Ser Ala Ile Ser Lys Ala Pro Val Ser 
                85                  90                  95      

Lys Tyr Pro Leu Val Ser Lys Glu Glu Ile Ile Ala Gly Ala Arg Glu 
            100                 105                 110         

Ala Glu Arg Arg Lys Ala Gly Thr Tyr Cys Ile Val Ile Ser Gly Arg 
        115                 120                 125             

Arg Pro Ser Asp Arg Glu Ile Glu Arg Ile Ala Glu Ala Val Glu Glu 
    130                 135                 140                 

Ile Arg Ala Thr Thr Thr Leu Lys Ile Cys Cys Cys Leu Gly Leu Leu 
145                 150                 155                 160 

Thr Pro Ala Gln Ala Asp Arg Leu Ala Arg Ala Gly Val His Arg Tyr 
                165                 170                 175     

Asn His Asn Leu Asn Thr Ser Lys Asp Arg Tyr Gly Asp Ile Cys Thr 
            180                 185                 190         

Thr His Thr Tyr Asp Asp Arg Val Arg Thr Leu Glu His Val Lys Glu 
        195                 200                 205             

Ala Gly Ile Ser Pro Cys Ser Gly Val Ile Phe Gly Met Gly Glu Ser 
    210                 215                 220                 

Asp Glu Glu Ala Val Asp Met Ala Phe Ala Leu Lys Glu Met Asp Ala 
225                 230                 235                 240 

Asp Ser Ile Pro Cys Asn Phe Leu Asn Pro Ile Pro Gly Thr Pro Leu 
                245                 250                 255     

Glu Gly Met Glu Thr Leu Asn Pro Arg Arg Cys Leu Lys Leu Leu Cys 
            260                 265                 270         

Met Met Arg Phe Val Asn Pro Ser Lys Glu Ile Arg Ile Ala Gly Gly 
        275                 280                 285             

Arg Glu Arg Asn Leu Arg Ser Leu Gln Val Leu Gly Leu Tyr Pro Ala 
    290                 295                 300                 

Asn Ser Ile Phe Val Gly Asp Tyr Leu Thr Thr Pro Gly Gln Ala Pro 
305                 310                 315                 320 

Thr Glu Asp Trp Ala Met Ile Glu Asp Leu Gly Phe Glu Ile Glu Glu 
                325                 330                 335     

Cys Ala Leu 
            

<210>   95
<211>   339
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   95
Met His Glu Gly Ala Leu Thr Met Met Lys Ile Asp Tyr Gln Thr Asn 
                5                   10                  15      

Trp Ile Asp Leu Ala Arg Arg Val Leu Asp Gly Arg Gly Val Thr Arg 
            20                  25                  30          

Glu Glu Ala Leu Asp Ile Leu Arg Ser Ser Asp Asp Glu Leu Leu Asp 
        35                  40                  45              

Leu Leu Ala Ala Ala Phe Leu Ile Arg Arg Arg Tyr Phe Gly Lys Lys 
    50                  55                  60                  

Val Lys Leu Asn Met Ile Ile Asn Ala Lys Ser Lys Met Cys Pro Glu 
65                  70                  75                  80  

Asp Cys Ala Tyr Cys Ser Gln Ser Ala Ile Ser Lys Ala Pro Val Ser 
                85                  90                  95      

Lys Tyr Pro Leu Val Ser Lys Glu Glu Ile Ile Ala Gly Ala Arg Glu 
            100                 105                 110         

Ala Asp Arg Arg Lys Ala Gly Thr Tyr Cys Ile Val Ile Ser Gly Arg 
        115                 120                 125             

Arg Pro Ser Asp Arg Glu Ile Glu Arg Ile Ala Glu Ala Val Glu Glu 
    130                 135                 140                 

Ile Arg Ala Thr Thr Thr Leu Lys Ile Cys Cys Cys Leu Gly Leu Leu 
145                 150                 155                 160 

Thr Pro Ala Gln Ala Asp Arg Leu Ala Arg Ala Gly Val His Arg Tyr 
                165                 170                 175     

Asn His Asn Leu Asn Thr Ser Arg Asp Arg Tyr Gly Asp Ile Cys Thr 
            180                 185                 190         

Thr His Thr Tyr Asp Asp Arg Val Arg Thr Leu Glu His Val Lys Glu 
        195                 200                 205             

Ala Gly Ile Ser Pro Cys Ser Gly Val Ile Phe Gly Met Gly Glu Ser 
    210                 215                 220                 

Asp Glu Glu Ala Val Asp Met Ala Phe Ala Leu Lys Glu Met Asp Ala 
225                 230                 235                 240 

Asp Ser Ile Pro Cys Asn Phe Leu Asn Pro Ile Pro Gly Thr Pro Leu 
                245                 250                 255     

Glu Gly Met Glu Thr Leu Asn Pro Arg Arg Cys Leu Lys Leu Leu Cys 
            260                 265                 270         

Met Met Arg Phe Val Asn Pro Ser Lys Glu Ile Arg Ile Ala Gly Gly 
        275                 280                 285             

Arg Glu Arg Asn Leu Arg Ser Leu Gln Val Leu Gly Leu Tyr Pro Ala 
    290                 295                 300                 

Asn Ser Ile Phe Val Gly Asp Tyr Leu Thr Thr Pro Gly Gln Ala Pro 
305                 310                 315                 320 

Thr Glu Asp Trp Ala Met Ile Glu Asp Leu Gly Phe Glu Ile Glu Glu 
                325                 330                 335     

Cys Ala Leu 
            

<210>   96
<211>   339
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   96
Met His Glu Gly Ala Leu Thr Met Met Lys Ile Asp Tyr Gln Thr Asn 
                5                   10                  15      

Trp Ile Asp Leu Ala Arg Arg Val Leu Asp Gly Lys Gly Val Thr Arg 
            20                  25                  30          

Glu Glu Ala Leu Asp Ile Leu Arg Ser Ser Asp Asp Glu Leu Leu Asp 
        35                  40                  45              

Leu Leu Ala Ala Ala Phe Leu Ile Arg Arg Arg Tyr Phe Gly Lys Lys 
    50                  55                  60                  

Val Lys Leu Asn Met Ile Ile Asn Ala Lys Ser Lys Met Cys Pro Glu 
65                  70                  75                  80  

Asp Cys Ala Tyr Cys Ser Gln Ser Ala Ile Ser Lys Ala Pro Val Ser 
                85                  90                  95      

Lys Tyr Pro Leu Val Ser Lys Glu Glu Ile Ile Ala Gly Ala Arg Glu 
            100                 105                 110         

Ala Glu Arg Arg Lys Ala Gly Thr Tyr Cys Ile Val Ile Ser Gly Arg 
        115                 120                 125             

Arg Pro Ser Asp Arg Glu Ile Glu Arg Ile Ala Glu Ala Val Glu Glu 
    130                 135                 140                 

Ile Arg Ala Thr Thr Thr Leu Lys Ile Cys Cys Cys Leu Gly Leu Leu 
145                 150                 155                 160 

Thr Pro Ala Gln Ala Asp Arg Leu Ala Arg Ala Gly Val His Arg Tyr 
                165                 170                 175     

Asn His Asn Leu Asn Thr Ser Arg Asp Arg Tyr Gly Asp Ile Cys Thr 
            180                 185                 190         

Thr His Thr Tyr Asp Asp Arg Val Arg Thr Leu Glu His Val Lys Glu 
        195                 200                 205             

Ala Gly Ile Ser Pro Cys Ser Gly Val Ile Phe Gly Met Gly Glu Ser 
    210                 215                 220                 

Asp Glu Glu Ala Val Asp Met Ala Phe Ala Leu Lys Glu Met Asp Ala 
225                 230                 235                 240 

Asp Ser Ile Pro Cys Asn Phe Leu Asn Pro Ile Pro Gly Thr Pro Leu 
                245                 250                 255     

Glu Gly Met Glu Thr Leu Asn Pro Arg Arg Cys Leu Lys Leu Leu Cys 
            260                 265                 270         

Met Met Arg Phe Val Asn Pro Ser Lys Glu Ile Arg Ile Ala Gly Gly 
        275                 280                 285             

Arg Glu Arg Asn Leu Arg Ser Leu Gln Val Leu Gly Leu Tyr Pro Ala 
    290                 295                 300                 

Asn Ser Ile Phe Val Gly Asp Tyr Leu Thr Thr Pro Gly Gln Ala Pro 
305                 310                 315                 320 

Thr Glu Asp Trp Ala Met Ile Glu Asp Leu Gly Phe Glu Ile Glu Glu 
                325                 330                 335     

Cys Ala Leu 
            

<210>   97
<211>   339
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   97
Met His Glu Gly Ala Leu Thr Met Met Lys Ile Asp Tyr Gln Thr Asn 
                5                   10                  15      

Trp Ile Asp Leu Ala Arg Arg Val Leu Asp Gly Arg Gly Val Thr Arg 
            20                  25                  30          

Glu Glu Ala Leu Asp Ile Leu Arg Ser Ser Asp Asp Glu Leu Leu Asp 
        35                  40                  45              

Leu Leu Ala Ala Ala Phe Leu Ile Arg Arg Arg Tyr Phe Gly Lys Lys 
    50                  55                  60                  

Val Lys Leu Asn Met Ile Ile Asn Ala Lys Ser Lys Met Cys Pro Glu 
65                  70                  75                  80  

Asp Cys Ala Tyr Cys Ser Gln Ser Ala Ile Ser Lys Ala Pro Val Ser 
                85                  90                  95      

Lys Tyr Pro Leu Val Ser Lys Glu Glu Ile Ile Ala Gly Ala Arg Glu 
            100                 105                 110         

Ala Glu Arg Arg Lys Ala Gly Thr Tyr Cys Ile Val Ile Ser Gly Arg 
        115                 120                 125             

Arg Pro Ser Asp Arg Glu Ile Glu Arg Ile Ala Glu Ala Val Glu Glu 
    130                 135                 140                 

Ile Arg Ala Thr Thr Thr Leu Lys Ile Cys Cys Cys Leu Gly Leu Leu 
145                 150                 155                 160 

Thr Pro Ala Gln Ala Asp Arg Leu Ala Arg Ala Gly Val His Arg Tyr 
                165                 170                 175     

Asn His Asn Leu Asn Thr Ser Arg Asp Arg Tyr Gly Asp Ile Cys Thr 
            180                 185                 190         

Thr His Thr Tyr Asp Asp Arg Val Arg Thr Leu Glu His Val Lys Glu 
        195                 200                 205             

Ala Gly Ile Ser Pro Cys Ser Gly Val Ile Phe Gly Met Gly Glu Ser 
    210                 215                 220                 

Asp Glu Glu Ala Val Asp Met Ala Phe Ala Leu Lys Glu Met Asp Ala 
225                 230                 235                 240 

Asp Ser Ile Pro Cys Asn Phe Leu Asn Pro Ile Pro Gly Thr Pro Leu 
                245                 250                 255     

Glu Gly Met Glu Thr Leu Asn Pro Arg Arg Cys Leu Lys Leu Leu Cys 
            260                 265                 270         

Met Met Arg Phe Val Asn Pro Ser Lys Glu Ile Arg Ile Ala Gly Gly 
        275                 280                 285             

Arg Glu Lys Asn Leu Arg Ser Leu Gln Val Leu Gly Leu Tyr Pro Ala 
    290                 295                 300                 

Asn Ser Ile Phe Val Gly Asp Tyr Leu Thr Thr Pro Gly Gln Ala Pro 
305                 310                 315                 320 

Thr Glu Asp Trp Ala Met Ile Glu Asp Leu Gly Phe Glu Ile Glu Glu 
                325                 330                 335     

Cys Ala Leu 
            

<210>   98
<211>   1020
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   98
gtgcacgagg gggcattgac catgatgaaa atcgattatc agaccaattg gattgacctc       60

gccaaacgcg tccttgatgg gcgcggcgtg actcgcgagg aagccctcga cattctgcgg      120

tcgagcgacg acgaactcct agatctcctc gccgccgcct tcttgattcg caggcgctac      180

ttcggtaaga aggtcaagct caacatgatc atcaacgcca agtcgaagat gtgccccgaa      240

gactgcgcgt actgctccca gtccgccatc tcaaaggccc cggtgtccaa gtatccgctg      300

gtctccaaag aggaaatcat cgccggcgcg cgcgaagccg agcgtcgcaa ggccggcacg      360

tattgcatcg tcatcagcgg aaggcggccg tcggatcggg agattgagcg catcgccgag      420

gccgtggagg aaatccgcgc caccacaacc ctcaagatct gctgctgcct cgggctcttg      480

acgcccgccc aggcggatcg gctcgcccgg gccggcgtgc accggtacaa tcacaacttg      540

aacacgagcc gagatcgata tggcgacatt tgcaccaccc acacctacga cgatcgcgtc      600

cggaccctgg agcacgtgaa agaggcgggc atctcgccgt gttcgggggt catcttcggc      660

atgggcgaat cggacgagga ggcggtggac atggcgtttg cgctgaagga gatggacgcc      720

gactccatcc cgtgcaactt tctgaatccc atcccaggca cgccgctcga aggcatggag      780

accttgaacc cgcggcggtg cctgaagctg ctctgcatga tgcgcttcgt gaatccgtcg      840

aaggagatcc gcatcgcagg cgggcgagag cgaaacctgc gcagcctgca ggtgctcggc      900

ctctacccgg ccaactccat cttcgtcggg gactacttga cgacgcccgg gcaggcgccg      960

acggaggact gggccatgat cgaagacctc gggtttgaga ttgaagaatg cgcgctgtga     1020


<210>   99
<211>   1020
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   99
gtgcacgagg gggcattgac catgatgaaa atcgattatc agaccaattg gattgacctc       60

gcccgtcgcg tccttgatgg gcgcggcgtg actcgcgagg aagccctcga cattctgcgg      120

tcgagcgacg acgaactcct agatctcctc gccgccgcct tcttgattcg caggcgctac      180

ttcggtaaga aggtcaagct caacatgatc atcaacgcca agtcgaagat gtgccccgaa      240

gactgcgcgt actgctccca gtccgccatc tcaaaggccc cggtgtccaa gtatccgctg      300

gtctccaaag aggaaatcat cgccggcgcg cgcgaagccg agcgtcgcaa ggccggcacg      360

tattgcatcg tcatcagcgg aaggcggccg tcggatcggg agattgagcg catcgccgag      420

gccgtggagg aaatccgcgc caccacaacc ctcaagatct gctgctgcct cgggctcttg      480

acgcccgccc aggcggatcg gctcgcccgg gccggcgtgc accggtacaa tcacaacttg      540

aacacgagca aagatcgata tggcgacatt tgcaccaccc acacctacga cgatcgcgtc      600

cggaccctgg agcacgtgaa agaggcgggc atctcgccgt gttcgggggt catcttcggc      660

atgggcgaat cggacgagga ggcggtggac atggcgtttg cgctgaagga gatggacgcc      720

gactccatcc cgtgcaactt tctgaatccc atcccaggca cgccgctcga aggcatggag      780

accttgaacc cgcggcggtg cctgaagctg ctctgcatga tgcgcttcgt gaatccgtcg      840

aaggagatcc gcatcgcagg cgggcgagag cgaaacctgc gcagcctgca ggtgctcggc      900

ctctacccgg ccaactccat cttcgtcggg gactacttga cgacgcccgg gcaggcgccg      960

acggaggact gggccatgat cgaagacctc gggtttgaga ttgaagaatg cgcgctgtga     1020


<210>   100
<211>   1020
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   100
gtgcacgagg gggcattgac catgatgaaa atcgattatc agaccaattg gattgacctc       60

gcccgtcgcg tccttgatgg gcgcggcgtg actcgcgagg aagccctcga cattctgcgg      120

tcgagcgacg acgaactcct agatctcctc gccgccgcct tcttgattcg caggcgctac      180

ttcggtaaga aggtcaagct caacatgatc atcaacgcca agtcgaagat gtgccccgaa      240

gactgcgcgt actgctccca gtccgccatc tcaaaggccc cggtgtccaa gtatccgctg      300

gtctccaaag aggaaatcat cgccggcgcg cgcgaagccg atcgtcgcaa ggccggcacg      360

tattgcatcg tcatcagcgg aaggcggccg tcggatcggg agattgagcg catcgccgag      420

gccgtggagg aaatccgcgc caccacaacc ctcaagatct gctgctgcct cgggctcttg      480

acgcccgccc aggcggatcg gctcgcccgg gccggcgtgc accggtacaa tcacaacttg      540

aacacgagcc gagatcgata tggcgacatt tgcaccaccc acacctacga cgatcgcgtc      600

cggaccctgg agcacgtgaa agaggcgggc atctcgccgt gttcgggggt catcttcggc      660

atgggcgaat cggacgagga ggcggtggac atggcgtttg cgctgaagga gatggacgcc      720

gactccatcc cgtgcaactt tctgaatccc atcccaggca cgccgctcga aggcatggag      780

accttgaacc cgcggcggtg cctgaagctg ctctgcatga tgcgcttcgt gaatccgtcg      840

aaggagatcc gcatcgcagg cgggcgagag cgaaacctgc gcagcctgca ggtgctcggc      900

ctctacccgg ccaactccat cttcgtcggg gactacttga cgacgcccgg gcaggcgccg      960

acggaggact gggccatgat cgaagacctc gggtttgaga ttgaagaatg cgcgctgtga     1020


<210>   101
<211>   1020
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   101
gtgcacgagg gggcattgac catgatgaaa atcgattatc agaccaattg gattgacctc       60

gcccgtcgcg tccttgatgg gaaaggcgtg actcgcgagg aagccctcga cattctgcgg      120

tcgagcgacg acgaactcct agatctcctc gccgccgcct tcttgattcg caggcgctac      180

ttcggtaaga aggtcaagct caacatgatc atcaacgcca agtcgaagat gtgccccgaa      240

gactgcgcgt actgctccca gtccgccatc tcaaaggccc cggtgtccaa gtatccgctg      300

gtctccaaag aggaaatcat cgccggcgcg cgcgaagccg agcgtcgcaa ggccggcacg      360

tattgcatcg tcatcagcgg aaggcggccg tcggatcggg agattgagcg catcgccgag      420

gccgtggagg aaatccgcgc caccacaacc ctcaagatct gctgctgcct cgggctcttg      480

acgcccgccc aggcggatcg gctcgcccgg gccggcgtgc accggtacaa tcacaacttg      540

aacacgagcc gagatcgata tggcgacatt tgcaccaccc acacctacga cgatcgcgtc      600

cggaccctgg agcacgtgaa agaggcgggc atctcgccgt gttcgggggt catcttcggc      660

atgggcgaat cggacgagga ggcggtggac atggcgtttg cgctgaagga gatggacgcc      720

gactccatcc cgtgcaactt tctgaatccc atcccaggca cgccgctcga aggcatggag      780

accttgaacc cgcggcggtg cctgaagctg ctctgcatga tgcgcttcgt gaatccgtcg      840

aaggagatcc gcatcgcagg cgggcgagag cgaaacctgc gcagcctgca ggtgctcggc      900

ctctacccgg ccaactccat cttcgtcggg gactacttga cgacgcccgg gcaggcgccg      960

acggaggact gggccatgat cgaagacctc gggtttgaga ttgaagaatg cgcgctgtga     1020


<210>   102
<211>   1020
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   102
gtgcacgagg gggcattgac catgatgaaa atcgattatc agaccaattg gattgacctc       60

gcccgtcgcg tccttgatgg gcgcggcgtg actcgcgagg aagccctcga cattctgcgg      120

tcgagcgacg acgaactcct agatctcctc gccgccgcct tcttgattcg caggcgctac      180

ttcggtaaga aggtcaagct caacatgatc atcaacgcca agtcgaagat gtgccccgaa      240

gactgcgcgt actgctccca gtccgccatc tcaaaggccc cggtgtccaa gtatccgctg      300

gtctccaaag aggaaatcat cgccggcgcg cgcgaagccg agcgtcgcaa ggccggcacg      360

tattgcatcg tcatcagcgg aaggcggccg tcggatcggg agattgagcg catcgccgag      420

gccgtggagg aaatccgcgc caccacaacc ctcaagatct gctgctgcct cgggctcttg      480

acgcccgccc aggcggatcg gctcgcccgg gccggcgtgc accggtacaa tcacaacttg      540

aacacgagcc gagatcgata tggcgacatt tgcaccaccc acacctacga cgatcgcgtc      600

cggaccctgg agcacgtgaa agaggcgggc atctcgccgt gttcgggggt catcttcggc      660

atgggcgaat cggacgagga ggcggtggac atggcgtttg cgctgaagga gatggacgcc      720

gactccatcc cgtgcaactt tctgaatccc atcccaggca cgccgctcga aggcatggag      780

accttgaacc cgcggcggtg cctgaagctg ctctgcatga tgcgcttcgt gaatccgtcg      840

aaggagatcc gcatcgcagg cgggcgagag aaaaacctgc gcagcctgca ggtgctcggc      900

ctctacccgg ccaactccat cttcgtcggg gactacttga cgacgcccgg gcaggcgccg      960

acggaggact gggccatgat cgaagacctc gggtttgaga ttgaagaatg cgcgctgtga     1020


<210>   103
<211>   268
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   103
Met Glu Thr Ile Ser Val Ser Gly Arg Trp Arg Asn Leu Leu His Gly 
                5                   10                  15      

Arg Arg Thr Met Lys Gly Leu Phe Ile Thr Ala Thr Asp Thr Glu Val 
            20                  25                  30          

Gly Lys Thr Trp Val Thr Gly Val Leu Ala Cys Ala Leu Arg His Arg 
        35                  40                  45              

Gly Tyr Asp Val Gly Val Cys Lys Pro Ile Gln Ser Gly Asn His Leu 
    50                  55                  60                  

Asp Asp Pro Glu Gly Asp Ala Ala Lys Leu Lys Arg Leu Ala Gly Val 
65                  70                  75                  80  

Ser Asp Ser Val Ser Asp Ile Cys Leu Cys Ala Leu Pro His Pro Val 
                85                  90                  95      

Ala Pro Gln Leu Ala Leu Lys Leu Ser Gly Leu Asp Leu Phe Leu Asp 
            100                 105                 110         

His Val Leu Ser Phe Val Gly Gln Ala Ala Lys Arg His Glu Trp Val 
        115                 120                 125             

Phe Val Glu Gly Ala Gly Gly Val Ala Val Pro Tyr Leu Ser Asp Ala 
    130                 135                 140                 

Trp Leu Val Asp Val Ile Gln Ala Leu Asn Phe Pro Val Leu Leu Val 
145                 150                 155                 160 

Ala Arg Ala Gly Leu Gly Thr Ile Asn His Thr Ile Leu Ser Ile Glu 
                165                 170                 175     

Tyr Leu Asn Arg Arg Gly Ile Arg Val Leu Gly Val Val Leu Asn Arg 
            180                 185                 190         

Gly Ser Asp Thr Tyr Ala Asp Asp Ala Pro Asp Lys Gln Ile Ser Phe 
        195                 200                 205             

Leu Leu Glu Arg Thr Asn Ser Asp Tyr Ile Arg Glu Ala Thr Gly Val 
    210                 215                 220                 

Pro Val Phe Gly Val Leu Pro Asn Met Ser Ser Cys Thr Val Glu Leu 
225                 230                 235                 240 

Glu Ile Val Asn Ala Val Glu Gln Asn Ile Asp Val Leu Gly Ile Ala 
                245                 250                 255     

Lys Ser Met Asn Ala Ile Tyr Glu Arg Pro Asn Val 
            260                 265             

<210>   104
<211>   807
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   104
ttggaaacca tctcggtgag cgggagatgg aggaacctct tgcacgggag aagaacaatg       60

aaaggactct ttatcacagc aactgacaca gaagtaggaa aaacatgggt aactggcgtt      120

ttggcatgtg ccttgcgcca caggggttac gacgtcgggg tctgcaagcc cattcagagt      180

ggaaaccact tggacgaccc agagggcgat gctgcgaagc tgaagcgctt ggcaggtgta      240

tcggacagcg tctcggacat ctgtctatgt gccctacctc atccggttgc accacagcta      300

gccttaaagt tgtccggttt ggatctcttt cttgatcacg tactctcttt cgttggccag      360

gctgcgaagc ggcatgagtg ggtgtttgtg gagggggcag gtggggttgc cgttccctat      420

ttatccgatg cgtggcttgt agatgtcatt caagctctta attttccagt cctacttgtg      480

gcacgagctg ggctgggaac gataaatcac acgatattgt ccatcgaata cctgaaccgc      540

cgcggaattc gagttttggg cgtcgtcttg aacaggggca gcgatactta cgcggacgat      600

gctccggata aacagatcag ttttcttcta gaacggacga atagcgacta cattcgcgaa      660

gcgacaggtg ttccggtatt tggtgtgctg ccgaatatgt cgtcatgcac tgtcgaacta      720

gagattgtga acgctgtcga acaaaatatt gatgtgcttg ggatagctaa atccatgaat      780

gctatatatg aaagacccaa tgtgtag                                          807


<210>   105
<211>   221
<212>   PRT
<213>   Bacillus weihenstephanensis KBAB4

<400>   105
Met Ser Gly Phe Phe Ile Thr Ala Thr Asp Thr Glu Val Gly Lys Thr 
                5                   10                  15      

Val Val Thr Gly Ala Leu Ala Gly Ile Phe Arg Glu Arg Gly His Asn 
            20                  25                  30          

Val Gly Val Tyr Lys Pro Leu Gln Ser Gly His Val Ala Ser Asn Pro 
        35                  40                  45              

Glu Gly Asp Ala Ala Arg Leu Lys Ala Leu Ser Gly Val Pro Thr Lys 
    50                  55                  60                  

Glu Asp Glu Ile Cys Pro Tyr Ser Ile Glu Glu Pro Leu Ala Pro Arg 
65                  70                  75                  80  

Leu Ala Met Lys Arg Ala Gly Arg Thr Val Met Leu Lys Glu Ile Thr 
                85                  90                  95      

Ala His Tyr Asn Glu Leu Leu Lys Glu Phe Asn Ser Leu Leu Val Glu 
            100                 105                 110         

Gly Ala Gly Gly Leu Ala Val Pro Tyr Thr Glu Asp Ala Leu Val Ile 
        115                 120                 125             

Asp Phe Ala Lys Glu Leu Gln Leu Pro Leu Ile Val Val Ala Arg Pro 
    130                 135                 140                 

Thr Leu Gly Thr Val Asn His Thr Val Leu Thr Ile Ser Tyr Ala Lys 
145                 150                 155                 160 

Ala His Gly Leu Thr Val Ala Gly Val Ile Leu Ser Gly Cys Lys Glu 
                165                 170                 175     

Cys Glu Lys Glu Arg Val Gln Glu Asn Lys Glu Met Ile Glu Glu Leu 
            180                 185                 190         

Ser Gly Val Pro Val Leu Gly Leu Leu Pro Phe Leu Glu Gly Glu Phe 
        195                 200                 205             

Thr Lys Glu Glu Leu Leu Glu Ser Val Lys Glu His Ile 
    210                 215                 220     

<210>   106
<211>   223
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   106
Met Ser Gly Phe Phe Ile Thr Ala Thr Asp Thr Glu Val Gly Lys Thr 
                5                   10                  15      

Val Val Thr Gly Ala Ile Ala Gly Gly Leu Arg Lys Leu Gly His His 
            20                  25                  30          

Ile Gly Val Tyr Lys Pro Leu Gln Ser Gly His Ser Ala Ser His Pro 
        35                  40                  45              

Glu Gly Asp Ala Ala Arg Leu Lys Met Ala Ser Gly Val Glu Thr Ala 
    50                  55                  60                  

Val Asp Lys Ile Cys Pro Tyr Ser Val Glu Glu Pro Leu Ala Pro Arg 
65                  70                  75                  80  

Leu Ala Met Gln Arg Ala Gly Arg Thr Val Thr Leu Ala Asp Ile Thr 
                85                  90                  95      

Ser Tyr Tyr Asn Glu Leu Met Ala Glu Phe Asp Ser Leu Leu Val Glu 
            100                 105                 110         

Gly Ala Gly Gly Leu Ala Val Pro Tyr Thr Glu Asp Ala Leu Val Val 
        115                 120                 125             

Asp Phe Ala Lys Gln Leu Lys Leu Pro Leu Ile Ile Val Ala Arg Pro 
    130                 135                 140                 

Thr Leu Gly Thr Val Asn His Thr Val Leu Thr Ile Ser Tyr Ala Lys 
145                 150                 155                 160 

Ala Lys Gly Leu Gln Val Ala Gly Val Ile Leu Ser Gly Cys Lys Glu 
                165                 170                 175     

Asp Glu Lys Glu Arg Val Gln Glu Asn Lys Lys Met Ile Glu Glu Leu 
            180                 185                 190         

Ser Asp Val Pro Val Phe Gly Leu Phe Pro Lys Ile Arg Glu Glu Tyr 
        195                 200                 205             

Thr Arg Asp Glu Leu Ile Lys Ala Ala Glu Glu Ser Ile Gln Ile 
    210                 215                 220             

<210>   107
<211>   221
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   107
Met Ser Gly Phe Phe Ile Thr Ala Thr Asp Thr Glu Val Gly Lys Thr 
                5                   10                  15      

Val Val Ala Gly Ala Ile Ala Gly Val Phe Arg Glu Leu Gly Tyr Asn 
            20                  25                  30          

Val Gly Val Tyr Lys Pro Leu Gln Ser Gly His Val Ala Ser Asn Pro 
        35                  40                  45              

Glu Gly Asp Ala Ala Arg Leu Lys Ser Leu Ser Gly Val Pro Thr Gln 
    50                  55                  60                  

Glu Asn Glu Ile Cys Pro Tyr Ser Ile Glu Glu Pro Leu Ala Pro Arg 
65                  70                  75                  80  

Leu Ala Met Lys Arg Ala Gly Arg Val Val Lys Leu Lys Glu Ile Thr 
                85                  90                  95      

Asp Tyr Tyr Asn Gly Leu Leu Lys Glu Phe Asn Ser Leu Phe Val Glu 
            100                 105                 110         

Gly Ala Gly Gly Leu Ala Val Pro Tyr Thr Glu Asp Ala Leu Val Ile 
        115                 120                 125             

Asp Phe Ala Lys Glu Leu Gln Leu Pro Leu Ile Val Val Ala Arg Pro 
    130                 135                 140                 

Thr Leu Gly Thr Val Asn His Thr Val Leu Thr Ile Ala Tyr Ala Lys 
145                 150                 155                 160 

Ala His Gly Leu Thr Val Ala Gly Val Ile Leu Ser Gly Cys Lys Glu 
                165                 170                 175     

Cys Glu Met Glu Arg Val Gln Glu Asn Lys Glu Met Ile Glu Glu Leu 
            180                 185                 190         

Ser Gly Val Pro Val Leu Gly Leu Leu Pro Phe Phe Ala Gly Glu Phe 
        195                 200                 205             

Thr Lys Glu Glu Val Leu Glu Ser Ala Lys Glu His Ile 
    210                 215                 220     

<210>   108
<211>   221
<212>   PRT
<213>   Bacillus thuringiensis serovar israelensis ATCC 35646

<400>   108
Met Ser Gly Phe Phe Ile Thr Ala Thr Asp Thr Glu Val Gly Lys Thr 
                5                   10                  15      

Val Val Ala Gly Ala Ile Ala Gly Val Phe Arg Glu Leu Gly Tyr Asn 
            20                  25                  30          

Val Gly Val Tyr Lys Pro Leu Gln Ser Gly His Val Ala Ser Asn Pro 
        35                  40                  45              

Glu Gly Asp Ala Ala Arg Leu Lys Val Leu Ser Gly Val Pro Thr Gln 
    50                  55                  60                  

Glu Asn Glu Ile Cys Pro Tyr Ser Ile Glu Glu Pro Leu Ala Pro Arg 
65                  70                  75                  80  

Leu Ala Met Lys Arg Ala Gly Arg Val Val Lys Leu Lys Glu Ile Thr 
                85                  90                  95      

Asp Tyr Tyr Asn Glu Leu Leu Lys Glu Phe Asn Ser Leu Phe Val Glu 
            100                 105                 110         

Gly Ala Gly Gly Leu Ala Val Pro Tyr Thr Glu Asp Ala Leu Val Ile 
        115                 120                 125             

Asp Phe Ala Lys Glu Leu Gln Leu Pro Leu Ile Val Val Ala Arg Pro 
    130                 135                 140                 

Thr Leu Gly Thr Val Asn His Thr Val Leu Thr Ile Ala Tyr Ala Lys 
145                 150                 155                 160 

Ala His Gly Leu Thr Val Ala Gly Val Ile Leu Ser Gly Cys Lys Glu 
                165                 170                 175     

Cys Glu Met Glu Arg Val Gln Glu Asn Lys Glu Met Ile Glu Glu Leu 
            180                 185                 190         

Ser Gly Val Pro Val Leu Gly Leu Leu Pro Phe Phe Glu Gly Glu Phe 
        195                 200                 205             

Thr Lys Glu Glu Val Leu Glu Ser Ala Lys Glu Tyr Ile 
    210                 215                 220     

<210>   109
<211>   221
<212>   PRT
<213>   Bacillus cereus E33L

<400>   109
Met Ser Gly Phe Phe Ile Thr Ala Thr Asp Thr Glu Val Gly Lys Thr 
                5                   10                  15      

Val Val Ala Gly Ala Leu Ala Gly Val Phe Arg Glu Leu Gly Tyr Asn 
            20                  25                  30          

Ile Gly Val Tyr Lys Pro Leu Gln Ser Gly His Val Ala Ser Asn Pro 
        35                  40                  45              

Glu Gly Asp Ala Ala Arg Leu Lys Ala Leu Ser Gly Val Pro Thr Lys 
    50                  55                  60                  

Glu Asp Glu Ile Cys Pro Tyr Ser Ile Glu Glu Pro Leu Ala Pro Arg 
65                  70                  75                  80  

Leu Ala Met Lys Arg Ala Gly Arg Thr Val Thr Leu Lys Asp Ile Ile 
                85                  90                  95      

His His Tyr Asn Glu Arg Leu Lys Glu Phe Asn Ser Leu Phe Val Glu 
            100                 105                 110         

Gly Ala Gly Gly Leu Ala Val Pro Tyr Thr Glu Asp Ala Leu Val Ile 
        115                 120                 125             

Asp Phe Ala Lys Glu Leu Gln Leu Pro Leu Ile Val Val Ala Arg Pro 
    130                 135                 140                 

Thr Leu Gly Thr Val Asn His Thr Val Leu Thr Ile Ala Tyr Ala Lys 
145                 150                 155                 160 

Ala His Gly Leu Thr Val Ala Gly Val Ile Leu Ser Gly Cys Lys Glu 
                165                 170                 175     

Cys Glu Met Glu Arg Val Gln Glu Asn Lys Val Met Ile Glu Glu Leu 
            180                 185                 190         

Ser Gly Val Pro Val Leu Gly Leu Leu Pro Phe Phe Glu Gly Glu Phe 
        195                 200                 205             

Thr Lys Lys Glu Val Leu Glu Ser Ala Lys Glu Tyr Ile 
    210                 215                 220     

<210>   110
<211>   268
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   110
Met Glu Thr Ile Ser Val Ser Gly Arg Trp Arg Asn Leu Leu His Gly 
                5                   10                  15      

Arg Arg Thr Met Lys Gly Leu Phe Ile Thr Ala Thr Asp Thr Glu Val 
            20                  25                  30          

Gly Lys Thr Trp Val Thr Gly Val Leu Ala Cys Ala Leu Arg His Arg 
        35                  40                  45              

Gly Tyr Asp Val Gly Val Cys Lys Pro Ile Gln Ser Gly Asn His Leu 
    50                  55                  60                  

Asp Asp Pro Glu Gly Asp Ala Ala Lys Leu Lys Arg Leu Ala Gly Val 
65                  70                  75                  80  

Ser Asp Ser Val Ser Asp Ile Cys Leu Cys Ala Leu Pro His Pro Val 
                85                  90                  95      

Ala Pro Gln Leu Ala Leu Lys Leu Ser Gly Leu Asp Leu Phe Leu Glu 
            100                 105                 110         

His Val Leu Ser Phe Val Gly Gln Ala Ala Lys Arg His Glu Trp Val 
        115                 120                 125             

Phe Val Glu Gly Ala Gly Gly Val Ala Val Pro Tyr Leu Ser Asp Ala 
    130                 135                 140                 

Trp Leu Val Asp Val Ile Gln Ala Leu Asn Phe Pro Val Leu Leu Val 
145                 150                 155                 160 

Ala Arg Ala Gly Leu Gly Thr Ile Asn His Thr Ile Leu Ser Ile Glu 
                165                 170                 175     

Tyr Leu Asn Arg Arg Gly Ile Arg Val Leu Gly Val Val Leu Asn Arg 
            180                 185                 190         

Gly Ser Asp Thr Tyr Ala Asp Asp Ala Pro Asp Lys Gln Ile Ser Phe 
        195                 200                 205             

Leu Leu Glu Arg Thr Asn Ser Asp Tyr Ile Arg Glu Ala Thr Gly Val 
    210                 215                 220                 

Pro Val Phe Gly Val Leu Pro Asn Met Ser Ser Cys Thr Val Glu Leu 
225                 230                 235                 240 

Glu Ile Val Asn Ala Val Glu Gln Asn Ile Asp Val Leu Gly Ile Ala 
                245                 250                 255     

Lys Ser Met Asn Ala Ile Tyr Glu Arg Pro Asn Val 
            260                 265             

<210>   111
<211>   268
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   111
Met Glu Thr Ile Ser Val Ser Gly Arg Trp Arg Asn Leu Leu His Gly 
                5                   10                  15      

Arg Arg Thr Met Lys Gly Leu Phe Ile Thr Ala Thr Asp Thr Glu Val 
            20                  25                  30          

Gly Lys Thr Trp Val Thr Gly Val Leu Ala Cys Ala Leu Arg His Arg 
        35                  40                  45              

Gly Tyr Asp Val Gly Val Cys Lys Pro Ile Gln Ser Gly Asn His Ile 
    50                  55                  60                  

Asp Asp Pro Glu Gly Asp Ala Ala Lys Leu Lys Arg Leu Ala Gly Val 
65                  70                  75                  80  

Ser Asp Ser Val Ser Asp Ile Cys Leu Cys Ala Leu Pro His Pro Val 
                85                  90                  95      

Ala Pro Gln Leu Ala Leu Lys Leu Ser Gly Leu Asp Leu Phe Leu Asp 
            100                 105                 110         

His Val Leu Ser Phe Val Gly Gln Ala Ala Lys Arg His Glu Trp Val 
        115                 120                 125             

Phe Val Glu Gly Ala Gly Gly Val Ala Val Pro Tyr Leu Ser Asp Ala 
    130                 135                 140                 

Trp Leu Val Asp Val Ile Gln Ala Leu Asn Phe Pro Val Leu Leu Val 
145                 150                 155                 160 

Ala Arg Ala Gly Leu Gly Thr Ile Asn His Thr Ile Leu Ser Ile Glu 
                165                 170                 175     

Tyr Leu Asn Arg Arg Gly Ile Arg Val Leu Gly Val Val Leu Asn Arg 
            180                 185                 190         

Gly Ser Asp Thr Tyr Ala Asp Asp Ala Pro Asp Lys Gln Ile Ser Phe 
        195                 200                 205             

Leu Leu Glu Arg Thr Asn Ser Asp Tyr Ile Arg Glu Ala Thr Gly Val 
    210                 215                 220                 

Pro Val Phe Gly Val Leu Pro Asn Met Ser Ser Cys Thr Val Glu Leu 
225                 230                 235                 240 

Glu Ile Val Asn Ala Val Glu Gln Asn Ile Asp Val Leu Gly Ile Ala 
                245                 250                 255     

Lys Ser Met Asn Ala Ile Tyr Glu Arg Pro Asn Val 
            260                 265             

<210>   112
<211>   268
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   112
Met Glu Thr Ile Ser Val Ser Gly Arg Trp Arg Asn Leu Leu His Gly 
                5                   10                  15      

Arg Arg Thr Met Lys Gly Leu Phe Ile Thr Ala Thr Asp Thr Glu Val 
            20                  25                  30          

Gly Lys Thr Trp Val Thr Gly Val Leu Ala Cys Ala Leu Arg His Arg 
        35                  40                  45              

Gly Tyr Asp Val Gly Val Cys Lys Pro Ile Gln Ser Gly Asn His Leu 
    50                  55                  60                  

Asp Asp Pro Glu Gly Asp Ala Ala Lys Leu Lys Arg Leu Ala Gly Val 
65                  70                  75                  80  

Ser Asp Ser Val Ser Asp Ile Cys Leu Cys Ala Leu Pro His Pro Val 
                85                  90                  95      

Ala Pro Gln Leu Ala Leu Lys Leu Ser Gly Leu Asp Leu Phe Leu Asp 
            100                 105                 110         

His Val Leu Ser Phe Val Gly Gln Ala Ala Lys Arg His Glu Trp Val 
        115                 120                 125             

Phe Val Glu Gly Ala Gly Gly Val Ala Val Pro Tyr Leu Ser Asp Ala 
    130                 135                 140                 

Trp Leu Val Asp Val Ile Gln Ala Leu Asn Phe Pro Val Leu Leu Val 
145                 150                 155                 160 

Ala Arg Ala Gly Leu Gly Thr Ile Asn His Thr Ile Leu Ser Ile Glu 
                165                 170                 175     

Tyr Leu Asn Arg Arg Gly Ile Arg Val Leu Gly Val Val Leu Asn Arg 
            180                 185                 190         

Gly Ser Asp Thr Tyr Ala Asp Asp Ala Pro Asp Lys Asn Ile Ser Phe 
        195                 200                 205             

Leu Leu Glu Arg Thr Asn Ser Asp Tyr Ile Arg Glu Ala Thr Gly Val 
    210                 215                 220                 

Pro Val Phe Gly Val Leu Pro Asn Met Ser Ser Cys Thr Val Glu Leu 
225                 230                 235                 240 

Glu Ile Val Asn Ala Val Glu Gln Asn Ile Asp Val Leu Gly Ile Ala 
                245                 250                 255     

Lys Ser Met Asn Ala Ile Tyr Glu Arg Pro Asn Val 
            260                 265             

<210>   113
<211>   268
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   113
Met Glu Thr Ile Ser Val Ser Gly Arg Trp Arg Asn Leu Leu His Gly 
                5                   10                  15      

Arg Arg Thr Met Lys Gly Leu Phe Ile Thr Ala Thr Asp Thr Glu Val 
            20                  25                  30          

Gly Lys Thr Trp Val Thr Gly Val Leu Ala Cys Ala Leu Arg His Arg 
        35                  40                  45              

Gly Tyr Asp Val Gly Val Cys Lys Pro Ile Gln Ser Gly Asn His Leu 
    50                  55                  60                  

Asp Asp Pro Glu Gly Asp Ala Ala Lys Leu Lys Arg Leu Ala Gly Val 
65                  70                  75                  80  

Ser Asp Ser Val Ser Asp Ile Cys Leu Cys Ala Leu Pro His Pro Val 
                85                  90                  95      

Ala Pro Gln Leu Ala Leu Lys Leu Ser Gly Leu Asp Leu Phe Leu Asp 
            100                 105                 110         

His Val Leu Ser Phe Val Gly Gln Ala Ala Lys Arg His Glu Trp Val 
        115                 120                 125             

Phe Val Glu Gly Ala Gly Gly Val Ala Val Pro Tyr Leu Ser Asp Ala 
    130                 135                 140                 

Trp Leu Val Asp Val Ile Gln Ala Leu Asn Phe Pro Val Leu Leu Val 
145                 150                 155                 160 

Ala Arg Ala Gly Leu Gly Thr Ile Asn His Thr Ile Leu Ser Ile Glu 
                165                 170                 175     

Tyr Ile Asn Arg Arg Gly Ile Arg Val Leu Gly Val Val Leu Asn Arg 
            180                 185                 190         

Gly Ser Asp Thr Tyr Ala Asp Asp Ala Pro Asp Lys Gln Ile Ser Phe 
        195                 200                 205             

Leu Leu Glu Arg Thr Asn Ser Asp Tyr Ile Arg Glu Ala Thr Gly Val 
    210                 215                 220                 

Pro Val Phe Gly Val Leu Pro Asn Met Ser Ser Cys Thr Val Glu Leu 
225                 230                 235                 240 

Glu Ile Val Asn Ala Val Glu Gln Asn Ile Asp Val Leu Gly Ile Ala 
                245                 250                 255     

Lys Ser Met Asn Ala Ile Tyr Glu Arg Pro Asn Val 
            260                 265             

<210>   114
<211>   268
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   114
Met Glu Thr Ile Ser Val Ser Gly Arg Trp Arg Asn Leu Leu His Gly 
                5                   10                  15      

Arg Arg Thr Met Lys Gly Leu Phe Ile Thr Ala Thr Asp Thr Glu Val 
            20                  25                  30          

Gly Lys Thr Trp Val Thr Gly Val Leu Ala Cys Ala Leu Arg His Arg 
        35                  40                  45              

Gly Tyr Asp Val Gly Val Cys Lys Pro Ile Gln Ser Gly Asn His Leu 
    50                  55                  60                  

Asp Asp Pro Glu Gly Asp Ala Ala Lys Leu Lys Lys Leu Ala Gly Val 
65                  70                  75                  80  

Ser Asp Ser Val Ser Asp Ile Cys Leu Cys Ala Leu Pro His Pro Val 
                85                  90                  95      

Ala Pro Gln Leu Ala Leu Lys Leu Ser Gly Leu Asp Leu Phe Leu Asp 
            100                 105                 110         

His Val Leu Ser Phe Val Gly Gln Ala Ala Lys Arg His Glu Trp Val 
        115                 120                 125             

Phe Val Glu Gly Ala Gly Gly Val Ala Val Pro Tyr Leu Ser Asp Ala 
    130                 135                 140                 

Trp Leu Val Asp Val Ile Gln Ala Leu Asn Phe Pro Val Leu Leu Val 
145                 150                 155                 160 

Ala Arg Ala Gly Leu Gly Thr Ile Asn His Thr Ile Leu Ser Ile Glu 
                165                 170                 175     

Tyr Leu Asn Arg Arg Gly Ile Arg Val Leu Gly Val Val Leu Asn Arg 
            180                 185                 190         

Gly Ser Asp Thr Tyr Ala Asp Asp Ala Pro Asp Lys Gln Ile Ser Phe 
        195                 200                 205             

Leu Leu Glu Arg Thr Asn Ser Asp Tyr Ile Arg Glu Ala Thr Gly Val 
    210                 215                 220                 

Pro Val Phe Gly Val Leu Pro Asn Met Ser Ser Cys Thr Val Glu Leu 
225                 230                 235                 240 

Glu Ile Val Asn Ala Val Glu Gln Asn Ile Asp Val Leu Gly Ile Ala 
                245                 250                 255     

Lys Ser Met Asn Ala Ile Tyr Glu Arg Pro Asn Val 
            260                 265             

<210>   115
<211>   807
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   115
ttggaaacca tctcggtgag cgggagatgg aggaacctct tgcacgggag aagaacaatg       60

aaaggactct ttatcacagc aactgacaca gaagtaggaa aaacatgggt aactggcgtt      120

ttggcatgtg ccttgcgcca caggggttac gacgtcgggg tctgcaagcc cattcagagt      180

ggaaaccact tggacgaccc agagggcgat gctgcgaagc tgaagcgctt ggcaggtgta      240

tcggacagcg tctcggacat ctgtctatgt gccctacctc atccggttgc accacagcta      300

gccttaaagt tgtccggttt ggatctcttt cttgaacacg tactctcttt cgttggccag      360

gctgcgaagc ggcatgagtg ggtgtttgtg gagggggcag gtggggttgc cgttccctat      420

ttatccgatg cgtggcttgt agatgtcatt caagctctta attttccagt cctacttgtg      480

gcacgagctg ggctgggaac gataaatcac acgatattgt ccatcgaata cctgaaccgc      540

cgcggaattc gagttttggg cgtcgtcttg aacaggggca gcgatactta cgcggacgat      600

gctccggata aacagatcag ttttcttcta gaacggacga atagcgacta cattcgcgaa      660

gcgacaggtg ttccggtatt tggtgtgctg ccgaatatgt cgtcatgcac tgtcgaacta      720

gagattgtga acgctgtcga acaaaatatt gatgtgcttg ggatagctaa atccatgaat      780

gctatatatg aaagacccaa tgtgtag                                          807


<210>   116
<211>   807
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   116
ttggaaacca tctcggtgag cgggagatgg aggaacctct tgcacgggag aagaacaatg       60

aaaggactct ttatcacagc aactgacaca gaagtaggaa aaacatgggt aactggcgtt      120

ttggcatgtg ccttgcgcca caggggttac gacgtcgggg tctgcaagcc cattcagagt      180

ggaaaccaca ttgacgaccc agagggcgat gctgcgaagc tgaagcgctt ggcaggtgta      240

tcggacagcg tctcggacat ctgtctatgt gccctacctc atccggttgc accacagcta      300

gccttaaagt tgtccggttt ggatctcttt cttgatcacg tactctcttt cgttggccag      360

gctgcgaagc ggcatgagtg ggtgtttgtg gagggggcag gtggggttgc cgttccctat      420

ttatccgatg cgtggcttgt agatgtcatt caagctctta attttccagt cctacttgtg      480

gcacgagctg ggctgggaac gataaatcac acgatattgt ccatcgaata cctgaaccgc      540

cgcggaattc gagttttggg cgtcgtcttg aacaggggca gcgatactta cgcggacgat      600

gctccggata aacagatcag ttttcttcta gaacggacga atagcgacta cattcgcgaa      660

gcgacaggtg ttccggtatt tggtgtgctg ccgaatatgt cgtcatgcac tgtcgaacta      720

gagattgtga acgctgtcga acaaaatatt gatgtgcttg ggatagctaa atccatgaat      780

gctatatatg aaagacccaa tgtgtag                                          807


<210>   117
<211>   807
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   117
ttggaaacca tctcggtgag cgggagatgg aggaacctct tgcacgggag aagaacaatg       60

aaaggactct ttatcacagc aactgacaca gaagtaggaa aaacatgggt aactggcgtt      120

ttggcatgtg ccttgcgcca caggggttac gacgtcgggg tctgcaagcc cattcagagt      180

ggaaaccact tggacgaccc agagggcgat gctgcgaagc tgaagcgctt ggcaggtgta      240

tcggacagcg tctcggacat ctgtctatgt gccctacctc atccggttgc accacagcta      300

gccttaaagt tgtccggttt ggatctcttt cttgatcacg tactctcttt cgttggccag      360

gctgcgaagc ggcatgagtg ggtgtttgtg gagggggcag gtggggttgc cgttccctat      420

ttatccgatg cgtggcttgt agatgtcatt caagctctta attttccagt cctacttgtg      480

gcacgagctg ggctgggaac gataaatcac acgatattgt ccatcgaata cctgaaccgc      540

cgcggaattc gagttttggg cgtcgtcttg aacaggggca gcgatactta cgcggacgat      600

gctccggata aaaatatcag ttttcttcta gaacggacga atagcgacta cattcgcgaa      660

gcgacaggtg ttccggtatt tggtgtgctg ccgaatatgt cgtcatgcac tgtcgaacta      720

gagattgtga acgctgtcga acaaaatatt gatgtgcttg ggatagctaa atccatgaat      780

gctatatatg aaagacccaa tgtgtag                                          807


<210>   118
<211>   807
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   118
ttggaaacca tctcggtgag cgggagatgg aggaacctct tgcacgggag aagaacaatg       60

aaaggactct ttatcacagc aactgacaca gaagtaggaa aaacatgggt aactggcgtt      120

ttggcatgtg ccttgcgcca caggggttac gacgtcgggg tctgcaagcc cattcagagt      180

ggaaaccact tggacgaccc agagggcgat gctgcgaagc tgaagcgctt ggcaggtgta      240

tcggacagcg tctcggacat ctgtctatgt gccctacctc atccggttgc accacagcta      300

gccttaaagt tgtccggttt ggatctcttt cttgatcacg tactctcttt cgttggccag      360

gctgcgaagc ggcatgagtg ggtgtttgtg gagggggcag gtggggttgc cgttccctat      420

ttatccgatg cgtggcttgt agatgtcatt caagctctta attttccagt cctacttgtg      480

gcacgagctg ggctgggaac gataaatcac acgatattgt ccatcgaata cattaaccgc      540

cgcggaattc gagttttggg cgtcgtcttg aacaggggca gcgatactta cgcggacgat      600

gctccggata aacagatcag ttttcttcta gaacggacga atagcgacta cattcgcgaa      660

gcgacaggtg ttccggtatt tggtgtgctg ccgaatatgt cgtcatgcac tgtcgaacta      720

gagattgtga acgctgtcga acaaaatatt gatgtgcttg ggatagctaa atccatgaat      780

gctatatatg aaagacccaa tgtgtag                                          807


<210>   119
<211>   807
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   119
ttggaaacca tctcggtgag cgggagatgg aggaacctct tgcacgggag aagaacaatg       60

aaaggactct ttatcacagc aactgacaca gaagtaggaa aaacatgggt aactggcgtt      120

ttggcatgtg ccttgcgcca caggggttac gacgtcgggg tctgcaagcc cattcagagt      180

ggaaaccact tggacgaccc agagggcgat gctgcgaagc tgaagaaatt ggcaggtgta      240

tcggacagcg tctcggacat ctgtctatgt gccctacctc atccggttgc accacagcta      300

gccttaaagt tgtccggttt ggatctcttt cttgatcacg tactctcttt cgttggccag      360

gctgcgaagc ggcatgagtg ggtgtttgtg gagggggcag gtggggttgc cgttccctat      420

ttatccgatg cgtggcttgt agatgtcatt caagctctta attttccagt cctacttgtg      480

gcacgagctg ggctgggaac gataaatcac acgatattgt ccatcgaata cctgaaccgc      540

cgcggaattc gagttttggg cgtcgtcttg aacaggggca gcgatactta cgcggacgat      600

gctccggata aacagatcag ttttcttcta gaacggacga atagcgacta cattcgcgaa      660

gcgacaggtg ttccggtatt tggtgtgctg ccgaatatgt cgtcatgcac tgtcgaacta      720

gagattgtga acgctgtcga acaaaatatt gatgtgcttg ggatagctaa atccatgaat      780

gctatatatg aaagacccaa tgtgtag                                          807


<210>   120
<211>   390
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   120
Met Leu Lys Ser Leu Glu Ser Arg Ile Val Asn Glu Leu Phe Asp Leu 
                5                   10                  15      

Arg Glu Ala Gly Arg His Arg Ser Leu His Ser Thr Val Val Arg Gly 
            20                  25                  30          

Ala Arg Met Trp Leu Glu Ser Lys Glu Val Leu His Phe Ser Ser Asn 
        35                  40                  45              

Asp Tyr Leu Ala Leu Ser Phe Asp His Arg Val Arg Glu Ala Ala Gln 
    50                  55                  60                  

Ala Ala Ser His Glu Tyr Gly Ala Gly Ala Thr Gly Ser Arg Leu Ile 
65                  70                  75                  80  

Ser Gly Asn His Pro Glu Ile Glu Gly Leu Glu Ala Glu Leu Ala Ser 
                85                  90                  95      

Trp His Gly Ala Glu Ala Ser Leu Val Phe Ser Ser Gly Tyr Ala Ala 
            100                 105                 110         

Asn Val Gly Val Leu Ser Ala Leu Val Arg Ser Asp Asp Val Val Phe 
        115                 120                 125             

Ser Asp Glu Leu Asn His Ala Ser Leu Ile Asp Gly Cys Arg Met Thr 
    130                 135                 140                 

Arg Ala Arg Val Val Val Tyr Arg His Ala Asp Val Gln His Leu Glu 
145                 150                 155                 160 

Gln Leu Met Arg Glu Thr Pro Cys Arg Gly Gln Arg Phe Val Val Ser 
                165                 170                 175     

Asp Ala Val Phe Ser Met Asp Gly Asp Ile Ala Pro Ile Ala Glu Leu 
            180                 185                 190         

Ile Glu Ile Ala Arg Leu Phe Glu Ala Val Val Ile Leu Asp Asp Ala 
        195                 200                 205             

His Gly Val Gly Met Leu Gly Arg Arg Gly Ala Gly Thr Leu Glu Asn 
    210                 215                 220                 

Phe Gly Ile Val Asn Val Asp Asp Ile Val Tyr Ile Gly Thr Leu Ser 
225                 230                 235                 240 

Lys Ala Leu Gly Ala Glu Gly Gly Tyr Val Ala Gly Arg Lys Ile Leu 
                245                 250                 255     

Ile Glu Tyr Leu Val Asn Arg Ala Arg Ser Phe Ile Phe Ser Thr Gly 
            260                 265                 270         

Leu Ser Pro Met Val Ala Ser Ser Ala Arg Lys Ala Arg Ser Ile Ala 
        275                 280                 285             

Glu Leu Glu Asp Trp Arg Arg Gln Lys Val Leu Ser Leu Ser Ser Ala 
    290                 295                 300                 

Leu Arg Thr Ser Leu Gln Gln Leu Gly Tyr Val Val Arg Gly Gly Glu 
305                 310                 315                 320 

Thr Pro Ile Val Pro Val Ile Val Gly Asp Glu His Ser Ser Leu Thr 
                325                 330                 335     

Ile Ser Arg His Leu Met Ser Tyr Gly Ile Tyr Val Pro Ala Ile Arg 
            340                 345                 350         

Pro Pro Ser Val Pro Glu Gly Lys Cys Arg Leu Arg Phe Ser Leu Thr 
        355                 360                 365             

Ala Ala His Glu Met Thr Asp Val Arg Leu Val Ile Asp Val Leu Lys 
    370                 375                 380                 

Asp Trp Lys Pro Ser Arg 
385                 390 

<210>   121
<211>   1173
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   121
atgttgaaat ccttagagtc gaggatcgta aatgagctct ttgacttacg tgaggctgga       60

aggcatcgaa gcttgcattc aactgtcgta cgaggcgcac gcatgtggct ggaatcgaaa      120

gaagttttac atttttcctc aaatgattac ctcgccctga gttttgacca ccgcgtgcgc      180

gaggctgccc aagcagcttc ccatgaatat ggggcgggag ctactggatc tcgacttatc      240

tctggaaacc atcccgagat agaggggctg gaagcagaat tggcgtcttg gcatggtgcc      300

gaggcaagcc ttgtattttc ctcgggttat gcggccaatg tcggtgtcct ttctgctctc      360

gtgaggtccg atgatgtcgt gttttccgat gagctcaatc atgcgagcct aatcgatggg      420

tgtcgtatga cacgagcgag ggtcgttgtg tatcgacatg ctgatgtgca acacctggag      480

cagctgatgc gggagacacc atgtcgcggt cagcgcttcg tggtttcaga cgctgtcttt      540

tcgatggatg gggacattgc gcccattgcc gaattgattg aaatcgcgcg tctcttcgag      600

gcggtagtga ttttggatga cgcgcacggc gtgggaatgt tgggtagacg gggagcagga      660

acgcttgaaa actttggtat tgtgaacgtc gacgatattg tctacatcgg aacgctttct      720

aaggcccttg gggcagaagg gggttatgtg gccggaagaa agatattgat tgaatatctt      780

gttaatcgcg caaggtcgtt cattttctca acaggcttgt caccgatggt tgcgagttcg      840

gcccgaaagg ctcgaagcat tgcggagctc gaggattggc ggcggcaaaa agtgctttct      900

ctgagcagcg cactccgaac aagtcttcag cagttgggtt acgtcgtgcg aggtggggaa      960

acgccgattg tacccgtcat tgtaggtgac gaacatagct cactgaccat atccaggcat     1020

ctcatgagct atggaatcta tgtgcctgcg atccggcccc cgtctgttcc tgaaggaaag     1080

tgccgactac gtttcagcct cacggcagca catgagatga cggatgtaag acttgttatc     1140

gacgtcttaa aggattggaa accatctcgg tga                                  1173


<210>   122
<211>   379
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   122
Met Lys Thr Glu Leu Thr Val Lys Leu His Glu Trp Glu Gln Lys Ala 
                5                   10                  15      

Gln Lys Arg Gln Leu Arg Arg Ala Glu Ala Ser Gly Ala Thr Val Ile 
            20                  25                  30          

Leu Asn Gly Lys Pro Met Leu Asn Leu Ala Ser Asn Asn Tyr Leu Gly 
        35                  40                  45              

Leu Ala Asp Asp Arg Arg Leu Ile Glu Ala Gly Cys Glu Ala Met Arg 
    50                  55                  60                  

Ala Tyr Gly Ala Gly Ala Gly Ala Ser Arg Leu Val Val Gly Asn His 
65                  70                  75                  80  

Pro Leu Tyr Glu Arg Ala Glu Ala Ala Leu Lys Gln Trp Lys Lys Ala 
                85                  90                  95      

Glu Ala Ala Leu Ile Phe Asn Ser Gly Tyr Thr Ala Asn Ile Gly Val 
            100                 105                 110         

Leu Thr Ala Leu Ile Gly Arg Asp Asp Leu Val Phe Ser Asp Lys Leu 
        115                 120                 125             

Asn His Ala Ser Leu Ile Asp Gly Ile Arg Leu Ser Lys Ala Ala Cys 
    130                 135                 140                 

Phe Arg Tyr Arg His His Asp Ile Asp Gln Leu Glu Ser Leu Leu Lys 
145                 150                 155                 160 

Gln Ser Pro Pro Ala Lys Arg Lys Trp Ile Val Thr Asp Ala Val Phe 
                165                 170                 175     

Ser Met Asp Gly Asp Met Ala Pro Leu Glu Glu Leu Val Glu Leu Lys 
            180                 185                 190         

Arg Arg Tyr Arg Ala Val Leu Leu Val Asp Glu Ala His Ser Gly Gly 
        195                 200                 205             

Val Phe Gly Pro Asn Gly Glu Gly Leu Leu His His Phe Gly Leu Glu 
    210                 215                 220                 

Lys Glu Glu Asp Val Ile Ala Ile Gly Thr Phe Ser Lys Ala Leu Gly 
225                 230                 235                 240 

Ser Phe Gly Ala Tyr Val Thr Gly Glu Pro Trp Leu Val Asp Tyr Leu 
                245                 250                 255     

Ile Asn Ser Ala Arg Ser Leu Ile Phe Thr Thr Ala Leu Pro Pro Ser 
            260                 265                 270         

Val Leu Ala Ala Asn Glu Ala Ala Ile His Ile Val Gln Ala Glu Pro 
        275                 280                 285             

Lys Arg Arg Glu Arg Leu His Ala Leu Ser Glu Arg Phe Arg Thr Lys 
    290                 295                 300                 

Leu Lys Arg Leu Gly Phe Asp Thr Gly Gly Ser Glu Thr Pro Ile Val 
305                 310                 315                 320 

Pro Val Ile Val Gly Pro Asn Asp Arg Ala Val Ala Met Ser Glu Gln 
                325                 330                 335     

Leu Gln Glu Ala Gly Ile Ala Ala Val Ala Ile Arg Pro Pro Thr Val 
            340                 345                 350         

Pro Glu Gly Thr Ala Arg Ile Arg Phe Ser Ile Thr Ala Ala Met Thr 
        355                 360                 365             

Glu Glu Asp Ile Asp Met Ala Val Asp Cys Ile 
    370                 375                 

<210>   123
<211>   366
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   123
Leu Asn Glu Arg Leu Asp Arg Met Lys Glu Ala Gly Val His Arg Asn 
                5                   10                  15      

Leu Arg Ser Met Asp Gly Ala Pro Val Pro Glu Arg Asn Ile Asp Gly 
            20                  25                  30          

Glu Asn Gln Thr Val Trp Ser Ser Asn Asn Tyr Leu Gly Leu Ala Ser 
        35                  40                  45              

Asp Arg Arg Leu Ile Asp Ala Ala Gln Thr Ala Leu Gln Gln Phe Gly 
    50                  55                  60                  

Thr Gly Ser Ser Gly Ser Arg Leu Thr Thr Gly Asn Ser Val Trp His 
65                  70                  75                  80  

Glu Lys Leu Glu Lys Lys Ile Ala Ser Phe Lys Leu Thr Glu Ala Ala 
                85                  90                  95      

Leu Leu Phe Ser Ser Gly Tyr Leu Ala Asn Val Gly Val Leu Ser Ser 
            100                 105                 110         

Leu Pro Glu Lys Glu Asp Val Ile Leu Ser Asp Gln Leu Asn His Ala 
        115                 120                 125             

Ser Met Ile Asp Gly Cys Arg Leu Ser Lys Ala Asp Thr Val Val Tyr 
    130                 135                 140                 

Arg His Ile Asp Met Asn Asp Leu Glu Asn Lys Leu Asn Glu Thr Gln 
145                 150                 155                 160 

Arg Tyr Gln Arg Arg Phe Ile Val Thr Asp Gly Val Phe Ser Met Asp 
                165                 170                 175     

Gly Thr Ile Ala Pro Leu Asp Gln Ile Ile Ser Leu Ala Lys Arg Tyr 
            180                 185                 190         

His Ala Phe Val Val Val Asp Asp Ala His Ala Thr Gly Val Leu Gly 
        195                 200                 205             

Asp Ser Gly Gln Gly Thr Ser Glu Tyr Phe Gly Val Cys Pro Asp Ile 
    210                 215                 220                 

Val Ile Gly Thr Leu Ser Lys Ala Val Gly Ala Glu Gly Gly Phe Ala 
225                 230                 235                 240 

Ala Gly Ser Ala Val Phe Ile Asp Phe Leu Leu Asn His Ala Arg Thr 
                245                 250                 255     

Phe Ile Phe Gln Thr Ala Ile Pro Pro Ala Ser Cys Ala Ala Ala His 
            260                 265                 270         

Glu Ala Phe Asn Ile Ile Glu Ala Ser Arg Glu Lys Arg Gln Leu Leu 
        275                 280                 285             

Phe Ser Tyr Ile Ser Met Ile Arg Thr Ser Leu Lys Asn Met Gly Tyr 
    290                 295                 300                 

Val Val Lys Gly Asp His Thr Pro Ile Ile Pro Val Val Ile Gly Asp 
305                 310                 315                 320 

Ala His Lys Thr Val Leu Phe Ala Glu Lys Leu Gln Gly Lys Gly Ile 
                325                 330                 335     

Tyr Ala Pro Ala Ile Arg Pro Pro Thr Val Ala Pro Gly Glu Ser Arg 
            340                 345                 350         

Ile Arg Ile Thr Ile Thr Ser Asp His Ser Met Gly Asp Ile 
        355                 360                 365     

<210>   124
<211>   368
<212>   PRT
<213>   Thermosinus carboxydivorans Nor1

<400>   124
Val Thr Glu Ala Leu Ala Glu Ile Lys Arg His Gly Leu Tyr Arg Gln 
                5                   10                  15      

Ile Pro Asp Tyr Asp Pro Val Asp Ala Val His Val Val Glu Asp Gly 
            20                  25                  30          

Arg Arg Tyr Leu Met Leu Ala Ser Asn Asn Tyr Leu Gly Leu Thr His 
        35                  40                  45              

Asp Pro Ala Val Arg Glu Ala Ala Ala Ala Ala Ala Leu Arg Tyr Gly 
    50                  55                  60                  

Ala Gly Ser Gly Gly Ala Arg Leu Thr Thr Gly Ser His Pro Leu Phe 
65                  70                  75                  80  

Ala Glu Leu Glu Arg Glu Leu Ala Ala Phe Lys Gly Thr Glu Ala Ala 
                85                  90                  95      

Leu Val Phe Asn Thr Gly Tyr Met Ala Asn Val Gly Ile Ile Ser Ala 
            100                 105                 110         

Leu Ala Gly Pro Gly Asp Val Ile Phe Ser Asp Glu Leu Asn His Ala 
        115                 120                 125             

Ser Ile Ile Asp Gly Cys Arg Leu Ala Arg Ala Lys Val Val Val Tyr 
    130                 135                 140                 

Arg His Ala Asp Ala Gly His Leu Ala Glu Cys Leu Ala Thr Thr Pro 
145                 150                 155                 160 

Cys Ala Gly Arg Arg Leu Ile Val Thr Asp Gly Val Phe Ser Met Asp 
                165                 170                 175     

Gly Asp Ile Ala Pro Leu Asp Gln Ile Val Pro Leu Ala Glu Gln Tyr 
            180                 185                 190         

Asp Ala Leu Val Met Val Asp Asp Ala His Ala Thr Gly Val Ile Gly 
        195                 200                 205             

Pro Gly Gly Arg Gly Thr Thr Ala Tyr Phe Gly Leu Lys Gly Arg Val 
    210                 215                 220                 

His Ile Glu Met Gly Thr Leu Ser Lys Ala Leu Ala Ala Glu Gly Gly 
225                 230                 235                 240 

Tyr Val Ala Gly Arg Arg Glu Leu Ile Asp Tyr Leu Val Asn Lys Ala 
                245                 250                 255     

Arg Ser Phe Ile Phe Ser Thr Ala Leu Ala Pro Ala Thr Val Ala Ala 
            260                 265                 270         

Ala Thr Ala Ala Leu Arg Glu Leu Ala Ala Arg Pro Ala Leu Val Ala 
        275                 280                 285             

Thr Leu Gln Ala Asn Ala Arg Tyr Leu Arg Asp Arg Leu Asn Glu Ala 
    290                 295                 300                 

Gly Phe Asn Val Ala Ser Ser Val Thr Ala Ile Ile Pro Val Ile Val 
305                 310                 315                 320 

Gly Glu Ala Asp Ala Ala Val Ala Met Ala Arg Ser Leu Lys Glu Ala 
                325                 330                 335     

Gly Leu Ile Val Ser Ala Ile Arg Pro Pro Thr Val Pro Pro Gly Thr 
            340                 345                 350         

Cys Arg Leu Arg Leu Thr Val Ser Ala Ala His Ser Arg Glu Asp Leu 
        355                 360                 365             

<210>   125
<211>   380
<212>   PRT
<213>   Bacillus sphaericus

<400>   125
Met Asn Asp Arg Phe Arg Arg Glu Leu Gln Val Ile Glu Glu Gln Gly 
                5                   10                  15      

Leu Thr Arg Lys Leu Arg Leu Phe Ser Thr Gly Asn Glu Ser Glu Val 
            20                  25                  30          

Val Met Asn Gly Lys Lys Phe Leu Leu Phe Ser Ser Asn Asn Tyr Leu 
        35                  40                  45              

Gly Leu Ala Thr Asp Ser Arg Leu Lys Lys Lys Ala Thr Glu Gly Ile 
    50                  55                  60                  

Ser Lys Tyr Gly Thr Gly Ala Gly Gly Ser Arg Leu Thr Thr Gly Asn 
65                  70                  75                  80  

Phe Asp Ile His Glu Gln Leu Glu Ser Glu Ile Ala Asp Phe Lys Lys 
                85                  90                  95      

Thr Glu Ala Ala Ile Val Phe Ser Ser Gly Tyr Leu Ala Asn Val Gly 
            100                 105                 110         

Val Ile Ser Ser Val Met Lys Ala Gly Asp Thr Ile Phe Ser Asp Ala 
        115                 120                 125             

Trp Asn His Ala Ser Ile Ile Asp Gly Cys Arg Leu Ser Lys Ala Lys 
    130                 135                 140                 

Thr Ile Val Tyr Glu His Ala Asp Met Val Asp Leu Glu Arg Lys Leu 
145                 150                 155                 160 

Arg Gln Ser His Gly Asp Gly Leu Lys Phe Ile Val Thr Asp Gly Val 
                165                 170                 175     

Phe Ser Met Asp Gly Asp Ile Ala Pro Leu Pro Lys Ile Val Glu Leu 
            180                 185                 190         

Ala Lys Glu Tyr Lys Ala Tyr Ile Met Ile Asp Asp Ala His Ala Thr 
        195                 200                 205             

Gly Val Leu Gly Asn Asp Gly Cys Gly Thr Ala Asp Tyr Phe Gly Leu 
    210                 215                 220                 

Lys Asp Glu Ile Asp Phe Thr Val Gly Thr Leu Ser Lys Ala Ile Gly 
225                 230                 235                 240 

Ala Glu Gly Gly Phe Val Ser Thr Ser Ser Ile Ala Lys Asn Tyr Leu 
                245                 250                 255     

Leu Asn Asn Ala Arg Ser Phe Ile Phe Gln Thr Ala Leu Ser Pro Ser 
            260                 265                 270         

Ala Ile Glu Ala Ala Arg Glu Gly Ile Ser Ile Ile Gln Asn Glu Pro 
        275                 280                 285             

Glu Arg Arg Lys Gln Leu Leu Lys Asn Ala Gln Tyr Leu Arg Leu Lys 
    290                 295                 300                 

Leu Glu Glu Ser Gly Phe Val Met Lys Glu Gly Glu Thr Pro Ile Ile 
305                 310                 315                 320 

Ser Leu Ile Ile Gly Gly Ser His Glu Ala Met Gln Phe Ser Ala Lys 
                325                 330                 335     

Leu Leu Asp Glu Gly Val Phe Ile Pro Ala Ile Arg Pro Pro Thr Val 
            340                 345                 350         

Pro Lys Gly Ser Ser Arg Leu Arg Ile Thr Val Met Ala Thr His Thr 
        355                 360                 365             

Ile Glu Gln Leu Asp Met Val Ile Ser Lys Ile Lys 
    370                 375                 380 

<210>   126
<211>   374
<212>   PRT
<213>   Kurthia sp. 538-KA26

<400>   126
Glu Leu Glu Lys Ile Lys Glu Gly Gly Leu Tyr Arg Gln Leu Gln Thr 
                5                   10                  15      

Val Glu Thr Met Ser Asp Gln Gly Tyr Ala Met Val Asn Gly Lys Lys 
            20                  25                  30          

Met Met Met Phe Ala Ser Asn Asn Tyr Leu Gly Ile Ala Asn Asp Gln 
        35                  40                  45              

Arg Leu Ile Glu Ala Ser Val Gln Ala Thr Gln Arg Phe Gly Thr Gly 
    50                  55                  60                  

Ser Thr Gly Ser Arg Leu Thr Thr Gly Asn Thr Ile Val His Glu Lys 
65                  70                  75                  80  

Leu Glu Lys Arg Leu Ala Glu Phe Lys Gln Thr Asp Ala Ala Ile Val 
                85                  90                  95      

Leu Asn Thr Gly Tyr Met Ala Asn Ile Ala Ala Leu Thr Thr Leu Val 
            100                 105                 110         

Gly Ser Asp Asp Leu Ile Leu Ser Asp Glu Met Asn His Ala Ser Ile 
        115                 120                 125             

Ile Asp Gly Cys Arg Leu Ser Arg Ala Glu Thr Ile Ile Tyr Arg His 
    130                 135                 140                 

Ala Asp Leu Leu Asp Leu Glu Met Lys Leu Gln Ile Asn Thr Arg Tyr 
145                 150                 155                 160 

Arg Lys Arg Ile Ile Val Thr Asp Gly Val Phe Ser Met Asp Gly Asp 
                165                 170                 175     

Ile Ala Pro Leu Pro Gly Ile Val Glu Leu Ala Lys Arg Tyr Asp Ala 
            180                 185                 190         

Leu Val Met Val Asp Asp Ala His Ala Thr Gly Val Leu Gly Lys Asp 
        195                 200                 205             

Gly Arg Gly Thr Ser Glu His Phe Gly Leu Lys Gly Lys Ile Asp Ile 
    210                 215                 220                 

Glu Met Gly Thr Leu Ser Lys Ala Val Gly Ala Glu Gly Gly Tyr Ile 
225                 230                 235                 240 

Ala Gly Ser Arg Ser Leu Val Asp Tyr Val Leu Asn Arg Ala Arg Pro 
                245                 250                 255     

Phe Val Phe Ser Thr Ala Leu Ser Ala Gly Val Val Ala Ser Ala Leu 
            260                 265                 270         

Thr Ala Val Asp Ile Ile Gln Ser Glu Pro Glu Arg Arg Val Arg Ile 
        275                 280                 285             

Arg Ala Met Ser Gln Arg Leu Tyr Asn Glu Leu Thr Ser Leu Gly Tyr 
    290                 295                 300                 

Thr Val Ser Gly Gly Glu Thr Pro Ile Leu Ala Ile Ile Cys Gly Glu 
305                 310                 315                 320 

Pro Glu Gln Ala Met Phe Leu Ser Lys Glu Leu His Lys His Gly Ile 
                325                 330                 335     

Tyr Ala Pro Ala Ile Arg Ser Pro Thr Val Pro Leu Gly Thr Ser Arg 
            340                 345                 350         

Ile Arg Leu Thr Leu Met Ala Thr His Gln Glu Glu Gln Met Asn His 
        355                 360                 365             

Val Ile Asp Val Phe Arg 
    370                 

<210>   127
<211>   390
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   127
Met Leu Lys Ser Leu Glu Ser Arg Ile Val Asn Glu Leu Phe Asp Leu 
                5                   10                  15      

Arg Glu Ala Gly Arg His Arg Ser Leu His Ser Thr Val Val Lys Gly 
            20                  25                  30          

Ala Arg Met Trp Leu Glu Ser Lys Glu Val Leu His Phe Ser Ser Asn 
        35                  40                  45              

Asp Tyr Leu Ala Leu Ser Phe Asp His Arg Val Arg Glu Ala Ala Gln 
    50                  55                  60                  

Ala Ala Ser His Glu Tyr Gly Ala Gly Ala Thr Gly Ser Arg Leu Ile 
65                  70                  75                  80  

Ser Gly Asn His Pro Glu Ile Glu Gly Leu Glu Ala Glu Leu Ala Ser 
                85                  90                  95      

Trp His Gly Ala Glu Ala Ser Leu Val Phe Ser Ser Gly Tyr Ala Ala 
            100                 105                 110         

Asn Val Gly Val Leu Ser Ala Leu Val Arg Ser Asp Asp Val Val Phe 
        115                 120                 125             

Ser Asp Glu Leu Asn His Ala Ser Leu Ile Asp Gly Cys Arg Met Thr 
    130                 135                 140                 

Arg Ala Arg Val Val Val Tyr Arg His Ala Asp Val Gln His Leu Glu 
145                 150                 155                 160 

Gln Leu Met Arg Glu Thr Pro Cys Arg Gly Gln Arg Phe Val Val Ser 
                165                 170                 175     

Asp Ala Val Phe Ser Met Asp Gly Asp Ile Ala Pro Ile Ala Glu Leu 
            180                 185                 190         

Ile Glu Ile Ala Arg Leu Phe Glu Ala Val Val Ile Leu Asp Asp Ala 
        195                 200                 205             

His Gly Val Gly Met Leu Gly Arg Arg Gly Ala Gly Thr Leu Glu Asn 
    210                 215                 220                 

Phe Gly Ile Val Asn Val Asp Asp Ile Val Tyr Ile Gly Thr Leu Ser 
225                 230                 235                 240 

Lys Ala Leu Gly Ala Glu Gly Gly Tyr Val Ala Gly Arg Lys Ile Leu 
                245                 250                 255     

Ile Glu Tyr Leu Val Asn Arg Ala Arg Ser Phe Ile Phe Ser Thr Gly 
            260                 265                 270         

Leu Ser Pro Met Val Ala Ser Ser Ala Arg Lys Ala Arg Ser Ile Ala 
        275                 280                 285             

Glu Leu Glu Asp Trp Arg Arg Gln Lys Val Leu Ser Leu Ser Ser Ala 
    290                 295                 300                 

Leu Arg Thr Ser Leu Gln Gln Leu Gly Tyr Val Val Arg Gly Gly Glu 
305                 310                 315                 320 

Thr Pro Ile Val Pro Val Ile Val Gly Asp Glu His Ser Ser Leu Thr 
                325                 330                 335     

Ile Ser Arg His Leu Met Ser Tyr Gly Ile Tyr Val Pro Ala Ile Arg 
            340                 345                 350         

Pro Pro Ser Val Pro Glu Gly Lys Cys Arg Leu Arg Phe Ser Leu Thr 
        355                 360                 365             

Ala Ala His Glu Met Thr Asp Val Arg Leu Val Ile Asp Val Leu Lys 
    370                 375                 380                 

Asp Trp Lys Pro Ser Arg 
385                 390 

<210>   128
<211>   390
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   128
Met Leu Lys Ser Leu Glu Ser Arg Ile Val Asn Glu Leu Phe Asp Leu 
                5                   10                  15      

Arg Glu Ala Gly Arg His Arg Ser Leu His Ser Thr Val Val Arg Gly 
            20                  25                  30          

Ala Arg Met Trp Leu Glu Ser Lys Glu Val Leu His Phe Ser Ser Asn 
        35                  40                  45              

Asp Tyr Leu Ala Leu Ser Phe Asp His Arg Val Arg Glu Ala Ala Gln 
    50                  55                  60                  

Ala Ala Ser His Glu Tyr Gly Ala Gly Ala Thr Gly Ser Arg Leu Ile 
65                  70                  75                  80  

Ser Gly Asn His Pro Glu Ile Glu Gly Leu Glu Ala Glu Leu Ala Ser 
                85                  90                  95      

Trp His Gly Ala Glu Ala Ser Leu Val Phe Ser Ser Gly Tyr Ala Ala 
            100                 105                 110         

Asn Val Gly Val Leu Ser Ala Leu Val Arg Ser Asp Asp Val Val Phe 
        115                 120                 125             

Ser Asp Glu Leu Asn His Ala Ser Leu Ile Asp Gly Cys Arg Met Thr 
    130                 135                 140                 

Arg Ala Arg Val Val Val Tyr Arg His Ala Asp Val Gln His Leu Glu 
145                 150                 155                 160 

Gln Leu Met Arg Glu Thr Pro Cys Arg Gly Gln Arg Phe Val Val Ser 
                165                 170                 175     

Asp Ala Val Phe Ser Met Asp Gly Asp Ile Ala Pro Ile Ala Glu Leu 
            180                 185                 190         

Ile Glu Ile Ala Arg Leu Phe Glu Ala Val Val Ile Leu Asp Asp Ala 
        195                 200                 205             

His Gly Val Gly Met Leu Gly Arg Arg Gly Ala Gly Thr Leu Glu Asn 
    210                 215                 220                 

Phe Gly Ile Val Asn Val Asp Asp Ile Val Tyr Ile Gly Thr Leu Ser 
225                 230                 235                 240 

Lys Ala Leu Gly Ala Glu Gly Gly Tyr Val Ala Gly Arg Lys Ile Leu 
                245                 250                 255     

Ile Glu Tyr Leu Val Asn Arg Ala Arg Ser Phe Ile Phe Ser Thr Gly 
            260                 265                 270         

Leu Ser Pro Met Val Ala Ser Ser Ala Arg Lys Ala Arg Ser Ile Ala 
        275                 280                 285             

Glu Leu Glu Asp Trp Arg Arg Gln Lys Val Leu Ser Leu Ser Ser Ala 
    290                 295                 300                 

Leu Arg Thr Ser Leu Gln Gln Leu Gly Tyr Val Val Lys Gly Gly Glu 
305                 310                 315                 320 

Thr Pro Ile Val Pro Val Ile Val Gly Asp Glu His Ser Ser Leu Thr 
                325                 330                 335     

Ile Ser Arg His Leu Met Ser Tyr Gly Ile Tyr Val Pro Ala Ile Arg 
            340                 345                 350         

Pro Pro Ser Val Pro Glu Gly Lys Cys Arg Leu Arg Phe Ser Leu Thr 
        355                 360                 365             

Ala Ala His Glu Met Thr Asp Val Arg Leu Val Ile Asp Val Leu Lys 
    370                 375                 380                 

Asp Trp Lys Pro Ser Arg 
385                 390 

<210>   129
<211>   390
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   129
Met Leu Lys Ser Leu Glu Ser Arg Ile Val Asn Glu Leu Phe Asp Leu 
                5                   10                  15      

Arg Glu Ala Gly Arg His Arg Ser Leu His Ser Thr Val Val Arg Gly 
            20                  25                  30          

Ala Arg Met Trp Leu Glu Ser Lys Glu Val Leu His Phe Ser Ser Asn 
        35                  40                  45              

Asp Tyr Leu Ala Leu Ser Phe Asp His Arg Val Arg Glu Ala Ala Gln 
    50                  55                  60                  

Ala Ala Ser His Glu Tyr Gly Ala Gly Ala Thr Gly Ser Arg Leu Ile 
65                  70                  75                  80  

Ser Gly Asn His Pro Glu Ile Glu Gly Leu Glu Ala Glu Leu Ala Ser 
                85                  90                  95      

Trp His Gly Ala Glu Ala Ser Leu Val Phe Ser Ser Gly Tyr Ala Ala 
            100                 105                 110         

Asn Val Gly Val Leu Ser Ala Leu Val Arg Ser Asp Asp Val Val Phe 
        115                 120                 125             

Ser Asp Glu Leu Asn His Ala Ser Leu Ile Asp Gly Cys Arg Met Thr 
    130                 135                 140                 

Arg Ala Arg Val Val Val Tyr Arg His Ala Asp Val Gln His Leu Glu 
145                 150                 155                 160 

Gln Leu Met Arg Asp Thr Pro Cys Arg Gly Gln Arg Phe Val Val Ser 
                165                 170                 175     

Asp Ala Val Phe Ser Met Asp Gly Asp Ile Ala Pro Ile Ala Glu Leu 
            180                 185                 190         

Ile Glu Ile Ala Arg Leu Phe Glu Ala Val Val Ile Leu Asp Asp Ala 
        195                 200                 205             

His Gly Val Gly Met Leu Gly Arg Arg Gly Ala Gly Thr Leu Glu Asn 
    210                 215                 220                 

Phe Gly Ile Val Asn Val Asp Asp Ile Val Tyr Ile Gly Thr Leu Ser 
225                 230                 235                 240 

Lys Ala Leu Gly Ala Glu Gly Gly Tyr Val Ala Gly Arg Lys Ile Leu 
                245                 250                 255     

Ile Glu Tyr Leu Val Asn Arg Ala Arg Ser Phe Ile Phe Ser Thr Gly 
            260                 265                 270         

Leu Ser Pro Met Val Ala Ser Ser Ala Arg Lys Ala Arg Ser Ile Ala 
        275                 280                 285             

Glu Leu Glu Asp Trp Arg Arg Gln Lys Val Leu Ser Leu Ser Ser Ala 
    290                 295                 300                 

Leu Arg Thr Ser Leu Gln Gln Leu Gly Tyr Val Val Arg Gly Gly Glu 
305                 310                 315                 320 

Thr Pro Ile Val Pro Val Ile Val Gly Asp Glu His Ser Ser Leu Thr 
                325                 330                 335     

Ile Ser Arg His Leu Met Ser Tyr Gly Ile Tyr Val Pro Ala Ile Arg 
            340                 345                 350         

Pro Pro Ser Val Pro Glu Gly Lys Cys Arg Leu Arg Phe Ser Leu Thr 
        355                 360                 365             

Ala Ala His Glu Met Thr Asp Val Arg Leu Val Ile Asp Val Leu Lys 
    370                 375                 380                 

Asp Trp Lys Pro Ser Arg 
385                 390 

<210>   130
<211>   390
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   130
Met Leu Lys Ser Leu Glu Ser Arg Ile Val Asn Glu Leu Phe Asp Leu 
                5                   10                  15      

Arg Glu Ala Gly Arg His Arg Ser Leu His Ser Thr Val Val Arg Gly 
            20                  25                  30          

Ala Arg Met Trp Leu Glu Ser Lys Glu Val Leu His Phe Ser Ser Asn 
        35                  40                  45              

Asp Tyr Leu Ala Leu Ser Phe Asp His Arg Val Arg Glu Ala Ala Gln 
    50                  55                  60                  

Ala Ala Ser His Glu Tyr Gly Ala Gly Ala Thr Gly Ser Arg Leu Ile 
65                  70                  75                  80  

Ser Gly Asn His Pro Glu Ile Glu Gly Leu Glu Ala Glu Leu Ala Ser 
                85                  90                  95      

Trp His Gly Ala Glu Ala Ser Leu Val Phe Ser Ser Gly Tyr Ala Ala 
            100                 105                 110         

Asn Val Gly Val Leu Ser Ala Leu Val Arg Ser Asp Asp Val Val Phe 
        115                 120                 125             

Ser Asp Glu Leu Asn His Ala Ser Leu Ile Asp Gly Cys Arg Met Thr 
    130                 135                 140                 

Arg Ala Arg Val Val Val Tyr Arg His Ala Asp Val Gln His Leu Glu 
145                 150                 155                 160 

Gln Leu Met Arg Glu Thr Pro Cys Arg Gly Gln Arg Phe Val Val Ser 
                165                 170                 175     

Asp Ala Val Phe Ser Met Asp Gly Asp Ile Ala Pro Ile Ala Glu Leu 
            180                 185                 190         

Ile Glu Ile Ala Arg Leu Phe Glu Ala Val Val Ile Leu Asp Asp Ala 
        195                 200                 205             

His Gly Val Gly Met Leu Gly Arg Arg Gly Ala Gly Thr Leu Glu Asn 
    210                 215                 220                 

Phe Gly Ile Val Asn Val Asp Asp Ile Val Tyr Ile Gly Thr Leu Ser 
225                 230                 235                 240 

Lys Ala Leu Gly Ala Asp Gly Gly Tyr Val Ala Gly Arg Lys Ile Leu 
                245                 250                 255     

Ile Glu Tyr Leu Val Asn Arg Ala Arg Ser Phe Ile Phe Ser Thr Gly 
            260                 265                 270         

Leu Ser Pro Met Val Ala Ser Ser Ala Arg Lys Ala Arg Ser Ile Ala 
        275                 280                 285             

Glu Leu Glu Asp Trp Arg Arg Gln Lys Val Leu Ser Leu Ser Ser Ala 
    290                 295                 300                 

Leu Arg Thr Ser Leu Gln Gln Leu Gly Tyr Val Val Arg Gly Gly Glu 
305                 310                 315                 320 

Thr Pro Ile Val Pro Val Ile Val Gly Asp Glu His Ser Ser Leu Thr 
                325                 330                 335     

Ile Ser Arg His Leu Met Ser Tyr Gly Ile Tyr Val Pro Ala Ile Arg 
            340                 345                 350         

Pro Pro Ser Val Pro Glu Gly Lys Cys Arg Leu Arg Phe Ser Leu Thr 
        355                 360                 365             

Ala Ala His Glu Met Thr Asp Val Arg Leu Val Ile Asp Val Leu Lys 
    370                 375                 380                 

Asp Trp Lys Pro Ser Arg 
385                 390 

<210>   131
<211>   390
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   131
Met Leu Lys Ser Leu Glu Ser Arg Ile Val Asn Asp Leu Phe Asp Leu 
                5                   10                  15      

Arg Glu Ala Gly Arg His Arg Ser Leu His Ser Thr Val Val Arg Gly 
            20                  25                  30          

Ala Arg Met Trp Leu Glu Ser Lys Glu Val Leu His Phe Ser Ser Asn 
        35                  40                  45              

Asp Tyr Leu Ala Leu Ser Phe Asp His Arg Val Arg Glu Ala Ala Gln 
    50                  55                  60                  

Ala Ala Ser His Glu Tyr Gly Ala Gly Ala Thr Gly Ser Arg Leu Ile 
65                  70                  75                  80  

Ser Gly Asn His Pro Glu Ile Glu Gly Leu Glu Ala Glu Leu Ala Ser 
                85                  90                  95      

Trp His Gly Ala Glu Ala Ser Leu Val Phe Ser Ser Gly Tyr Ala Ala 
            100                 105                 110         

Asn Val Gly Val Leu Ser Ala Leu Val Arg Ser Asp Asp Val Val Phe 
        115                 120                 125             

Ser Asp Glu Leu Asn His Ala Ser Leu Ile Asp Gly Cys Arg Met Thr 
    130                 135                 140                 

Arg Ala Arg Val Val Val Tyr Arg His Ala Asp Val Gln His Leu Glu 
145                 150                 155                 160 

Gln Leu Met Arg Glu Thr Pro Cys Arg Gly Gln Arg Phe Val Val Ser 
                165                 170                 175     

Asp Ala Val Phe Ser Met Asp Gly Asp Ile Ala Pro Ile Ala Glu Leu 
            180                 185                 190         

Ile Glu Ile Ala Arg Leu Phe Glu Ala Val Val Ile Leu Asp Asp Ala 
        195                 200                 205             

His Gly Val Gly Met Leu Gly Arg Arg Gly Ala Gly Thr Leu Glu Asn 
    210                 215                 220                 

Phe Gly Ile Val Asn Val Asp Asp Ile Val Tyr Ile Gly Thr Leu Ser 
225                 230                 235                 240 

Lys Ala Leu Gly Ala Glu Gly Gly Tyr Val Ala Gly Arg Lys Ile Leu 
                245                 250                 255     

Ile Glu Tyr Leu Val Asn Arg Ala Arg Ser Phe Ile Phe Ser Thr Gly 
            260                 265                 270         

Leu Ser Pro Met Val Ala Ser Ser Ala Arg Lys Ala Arg Ser Ile Ala 
        275                 280                 285             

Glu Leu Glu Asp Trp Arg Arg Gln Lys Val Leu Ser Leu Ser Ser Ala 
    290                 295                 300                 

Leu Arg Thr Ser Leu Gln Gln Leu Gly Tyr Val Val Arg Gly Gly Glu 
305                 310                 315                 320 

Thr Pro Ile Val Pro Val Ile Val Gly Asp Glu His Ser Ser Leu Thr 
                325                 330                 335     

Ile Ser Arg His Leu Met Ser Tyr Gly Ile Tyr Val Pro Ala Ile Arg 
            340                 345                 350         

Pro Pro Ser Val Pro Glu Gly Lys Cys Arg Leu Arg Phe Ser Leu Thr 
        355                 360                 365             

Ala Ala His Glu Met Thr Asp Val Arg Leu Val Ile Asp Val Leu Lys 
    370                 375                 380                 

Asp Trp Lys Pro Ser Arg 
385                 390 

<210>   132
<211>   1173
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   132
atgttgaaat ccttagagtc gaggatcgta aatgagctct ttgacttacg tgaggctgga       60

aggcatcgaa gcttgcattc aactgtcgta aaaggcgcac gcatgtggct ggaatcgaaa      120

gaagttttac atttttcctc aaatgattac ctcgccctga gttttgacca ccgcgtgcgc      180

gaggctgccc aagcagcttc ccatgaatat ggggcgggag ctactggatc tcgacttatc      240

tctggaaacc atcccgagat agaggggctg gaagcagaat tggcgtcttg gcatggtgcc      300

gaggcaagcc ttgtattttc ctcgggttat gcggccaatg tcggtgtcct ttctgctctc      360

gtgaggtccg atgatgtcgt gttttccgat gagctcaatc atgcgagcct aatcgatggg      420

tgtcgtatga cacgagcgag ggtcgttgtg tatcgacatg ctgatgtgca acacctggag      480

cagctgatgc gggagacacc atgtcgcggt cagcgcttcg tggtttcaga cgctgtcttt      540

tcgatggatg gggacattgc gcccattgcc gaattgattg aaatcgcgcg tctcttcgag      600

gcggtagtga ttttggatga cgcgcacggc gtgggaatgt tgggtagacg gggagcagga      660

acgcttgaaa actttggtat tgtgaacgtc gacgatattg tctacatcgg aacgctttct      720

aaggcccttg gggcagaagg gggttatgtg gccggaagaa agatattgat tgaatatctt      780

gttaatcgcg caaggtcgtt cattttctca acaggcttgt caccgatggt tgcgagttcg      840

gcccgaaagg ctcgaagcat tgcggagctc gaggattggc ggcggcaaaa agtgctttct      900

ctgagcagcg cactccgaac aagtcttcag cagttgggtt acgtcgtgcg aggtggggaa      960

acgccgattg tacccgtcat tgtaggtgac gaacatagct cactgaccat atccaggcat     1020

ctcatgagct atggaatcta tgtgcctgcg atccggcccc cgtctgttcc tgaaggaaag     1080

tgccgactac gtttcagcct cacggcagca catgagatga cggatgtaag acttgttatc     1140

gacgtcttaa aggattggaa accatctcgg tga                                  1173


<210>   133
<211>   1173
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   133
atgttgaaat ccttagagtc gaggatcgta aatgagctct ttgacttacg tgaggctgga       60

aggcatcgaa gcttgcattc aactgtcgta cgaggcgcac gcatgtggct ggaatcgaaa      120

gaagttttac atttttcctc aaatgattac ctcgccctga gttttgacca ccgcgtgcgc      180

gaggctgccc aagcagcttc ccatgaatat ggggcgggag ctactggatc tcgacttatc      240

tctggaaacc atcccgagat agaggggctg gaagcagaat tggcgtcttg gcatggtgcc      300

gaggcaagcc ttgtattttc ctcgggttat gcggccaatg tcggtgtcct ttctgctctc      360

gtgaggtccg atgatgtcgt gttttccgat gagctcaatc atgcgagcct aatcgatggg      420

tgtcgtatga cacgagcgag ggtcgttgtg tatcgacatg ctgatgtgca acacctggag      480

cagctgatgc gggagacacc atgtcgcggt cagcgcttcg tggtttcaga cgctgtcttt      540

tcgatggatg gggacattgc gcccattgcc gaattgattg aaatcgcgcg tctcttcgag      600

gcggtagtga ttttggatga cgcgcacggc gtgggaatgt tgggtagacg gggagcagga      660

acgcttgaaa actttggtat tgtgaacgtc gacgatattg tctacatcgg aacgctttct      720

aaggcccttg gggcagaagg gggttatgtg gccggaagaa agatattgat tgaatatctt      780

gttaatcgcg caaggtcgtt cattttctca acaggcttgt caccgatggt tgcgagttcg      840

gcccgaaagg ctcgaagcat tgcggagctc gaggattggc ggcggcaaaa agtgctttct      900

ctgagcagcg cactccgaac aagtcttcag cagttgggtt acgtcgtgaa aggtggggaa      960

acgccgattg tacccgtcat tgtaggtgac gaacatagct cactgaccat atccaggcat     1020

ctcatgagct atggaatcta tgtgcctgcg atccggcccc cgtctgttcc tgaaggaaag     1080

tgccgactac gtttcagcct cacggcagca catgagatga cggatgtaag acttgttatc     1140

gacgtcttaa aggattggaa accatctcgg tga                                  1173


<210>   134
<211>   1173
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   134
atgttgaaat ccttagagtc gaggatcgta aatgagctct ttgacttacg tgaggctgga       60

aggcatcgaa gcttgcattc aactgtcgta cgaggcgcac gcatgtggct ggaatcgaaa      120

gaagttttac atttttcctc aaatgattac ctcgccctga gttttgacca ccgcgtgcgc      180

gaggctgccc aagcagcttc ccatgaatat ggggcgggag ctactggatc tcgacttatc      240

tctggaaacc atcccgagat agaggggctg gaagcagaat tggcgtcttg gcatggtgcc      300

gaggcaagcc ttgtattttc ctcgggttat gcggccaatg tcggtgtcct ttctgctctc      360

gtgaggtccg atgatgtcgt gttttccgat gagctcaatc atgcgagcct aatcgatggg      420

tgtcgtatga cacgagcgag ggtcgttgtg tatcgacatg ctgatgtgca acacctggag      480

cagctgatgc gggatacacc atgtcgcggt cagcgcttcg tggtttcaga cgctgtcttt      540

tcgatggatg gggacattgc gcccattgcc gaattgattg aaatcgcgcg tctcttcgag      600

gcggtagtga ttttggatga cgcgcacggc gtgggaatgt tgggtagacg gggagcagga      660

acgcttgaaa actttggtat tgtgaacgtc gacgatattg tctacatcgg aacgctttct      720

aaggcccttg gggcagaagg gggttatgtg gccggaagaa agatattgat tgaatatctt      780

gttaatcgcg caaggtcgtt cattttctca acaggcttgt caccgatggt tgcgagttcg      840

gcccgaaagg ctcgaagcat tgcggagctc gaggattggc ggcggcaaaa agtgctttct      900

ctgagcagcg cactccgaac aagtcttcag cagttgggtt acgtcgtgcg aggtggggaa      960

acgccgattg tacccgtcat tgtaggtgac gaacatagct cactgaccat atccaggcat     1020

ctcatgagct atggaatcta tgtgcctgcg atccggcccc cgtctgttcc tgaaggaaag     1080

tgccgactac gtttcagcct cacggcagca catgagatga cggatgtaag acttgttatc     1140

gacgtcttaa aggattggaa accatctcgg tga                                  1173


<210>   135
<211>   1173
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   135
atgttgaaat ccttagagtc gaggatcgta aatgagctct ttgacttacg tgaggctgga       60

aggcatcgaa gcttgcattc aactgtcgta cgaggcgcac gcatgtggct ggaatcgaaa      120

gaagttttac atttttcctc aaatgattac ctcgccctga gttttgacca ccgcgtgcgc      180

gaggctgccc aagcagcttc ccatgaatat ggggcgggag ctactggatc tcgacttatc      240

tctggaaacc atcccgagat agaggggctg gaagcagaat tggcgtcttg gcatggtgcc      300

gaggcaagcc ttgtattttc ctcgggttat gcggccaatg tcggtgtcct ttctgctctc      360

gtgaggtccg atgatgtcgt gttttccgat gagctcaatc atgcgagcct aatcgatggg      420

tgtcgtatga cacgagcgag ggtcgttgtg tatcgacatg ctgatgtgca acacctggag      480

cagctgatgc gggagacacc atgtcgcggt cagcgcttcg tggtttcaga cgctgtcttt      540

tcgatggatg gggacattgc gcccattgcc gaattgattg aaatcgcgcg tctcttcgag      600

gcggtagtga ttttggatga cgcgcacggc gtgggaatgt tgggtagacg gggagcagga      660

acgcttgaaa actttggtat tgtgaacgtc gacgatattg tctacatcgg aacgctttct      720

aaggcccttg gggcagatgg gggttatgtg gccggaagaa agatattgat tgaatatctt      780

gttaatcgcg caaggtcgtt cattttctca acaggcttgt caccgatggt tgcgagttcg      840

gcccgaaagg ctcgaagcat tgcggagctc gaggattggc ggcggcaaaa agtgctttct      900

ctgagcagcg cactccgaac aagtcttcag cagttgggtt acgtcgtgcg aggtggggaa      960

acgccgattg tacccgtcat tgtaggtgac gaacatagct cactgaccat atccaggcat     1020

ctcatgagct atggaatcta tgtgcctgcg atccggcccc cgtctgttcc tgaaggaaag     1080

tgccgactac gtttcagcct cacggcagca catgagatga cggatgtaag acttgttatc     1140

gacgtcttaa aggattggaa accatctcgg tga                                  1173


<210>   136
<211>   1173
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   136
atgttgaaat ccttagagtc gaggatcgta aatgatctct ttgacttacg tgaggctgga       60

aggcatcgaa gcttgcattc aactgtcgta cgaggcgcac gcatgtggct ggaatcgaaa      120

gaagttttac atttttcctc aaatgattac ctcgccctga gttttgacca ccgcgtgcgc      180

gaggctgccc aagcagcttc ccatgaatat ggggcgggag ctactggatc tcgacttatc      240

tctggaaacc atcccgagat agaggggctg gaagcagaat tggcgtcttg gcatggtgcc      300

gaggcaagcc ttgtattttc ctcgggttat gcggccaatg tcggtgtcct ttctgctctc      360

gtgaggtccg atgatgtcgt gttttccgat gagctcaatc atgcgagcct aatcgatggg      420

tgtcgtatga cacgagcgag ggtcgttgtg tatcgacatg ctgatgtgca acacctggag      480

cagctgatgc gggagacacc atgtcgcggt cagcgcttcg tggtttcaga cgctgtcttt      540

tcgatggatg gggacattgc gcccattgcc gaattgattg aaatcgcgcg tctcttcgag      600

gcggtagtga ttttggatga cgcgcacggc gtgggaatgt tgggtagacg gggagcagga      660

acgcttgaaa actttggtat tgtgaacgtc gacgatattg tctacatcgg aacgctttct      720

aaggcccttg gggcagaagg gggttatgtg gccggaagaa agatattgat tgaatatctt      780

gttaatcgcg caaggtcgtt cattttctca acaggcttgt caccgatggt tgcgagttcg      840

gcccgaaagg ctcgaagcat tgcggagctc gaggattggc ggcggcaaaa agtgctttct      900

ctgagcagcg cactccgaac aagtcttcag cagttgggtt acgtcgtgcg aggtggggaa      960

acgccgattg tacccgtcat tgtaggtgac gaacatagct cactgaccat atccaggcat     1020

ctcatgagct atggaatcta tgtgcctgcg atccggcccc cgtctgttcc tgaaggaaag     1080

tgccgactac gtttcagcct cacggcagca catgagatga cggatgtaag acttgttatc     1140

gacgtcttaa aggattggaa accatctcgg tga                                  1173


<210>   137
<211>   297
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   137
Met Asp Val Ala Ser Gln Val Phe Leu Asp Gly Glu Phe Val Ser Ser 
                5                   10                  15      

Asp Ala Ala Ser Val Ser Val Phe Asp His Gly Leu Leu Tyr Gly Asp 
            20                  25                  30          

Gly Val Phe Glu Gly Ile Arg Ala Tyr Asp Gly Asn Val Phe Arg Leu 
        35                  40                  45              

Lys Pro His Met Asp Arg Leu Tyr Arg Ser Ala Lys Ser Ile Leu Leu 
    50                  55                  60                  

Glu Ile Pro Tyr Thr Gln Asp Glu Leu Thr Glu Leu Val Cys Glu Thr 
65                  70                  75                  80  

Val Arg Arg Asn His Leu Ser Ser Ala Tyr Ile Arg Leu Val Val Thr 
                85                  90                  95      

Arg Gly Ser Gly Asp Leu Gly Leu Asn Pro Tyr Asn Cys Ala Lys Ala 
            100                 105                 110         

Arg Val Phe Ile Ile Ala Glu Gln Leu Ser Met Phe Pro Lys Ala Leu 
        115                 120                 125             

Tyr Glu Gln Gly Ile Arg Ala Ile Thr Ala Ala Thr Arg Arg Thr Arg 
    130                 135                 140                 

Gly Asp Val Leu Asn Pro Lys Ile Lys Ser Leu Asn Tyr Leu Asn Asn 
145                 150                 155                 160 

Ile Leu Ile Lys Met Glu Ala Ile His Ala Gly Ala Asn Glu Ala Ile 
                165                 170                 175     

Val Leu Asn His Glu Gly Tyr Val Val Glu Gly Ser Gly Glu Asn Ile 
            180                 185                 190         

Phe Leu Val Arg Asp Gly Val Leu Ile Thr Pro Pro Ala Tyr Leu Gly 
        195                 200                 205             

Ala Leu Glu Gly Ile Thr Arg Gln Ala Val Ile Asp Leu Ala Pro Ala 
    210                 215                 220                 

Leu Gly Leu Glu Val Arg Gln Glu Pro Phe Thr Gln His Asp Val Tyr 
225                 230                 235                 240 

Val Ala Asp Glu Val Phe Leu Thr Gly Thr Ala Ala Glu Ile Val Pro 
                245                 250                 255     

Val Val Glu Val Asp Arg Arg Ala Ile Gly His Gly Val Pro Gly Pro 
            260                 265                 270         

Val Thr Lys Arg Val His Ala Ala Phe Gln Glu Ile Val Arg Ala Asp 
        275                 280                 285             

Gly Val Arg Ile Glu Gly Ala Arg Val 
    290                 295         

<210>   138
<211>   894
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   138
ttggacgtgg catcacaggt ttttcttgac ggcgaatttg tctccagcga cgcagccagc       60

gtgtcagtgt tcgatcacgg cctcctgtac ggcgatggcg tcttcgaagg aatccgcgca      120

tatgacggga acgtattccg cctcaagccg cacatggacc gactttatcg ttcggccaag      180

tccattcttc tcgagattcc gtatacgcag gacgaattga cggaactcgt gtgcgagacc      240

gtccggcgca atcatctgtc ctcggcgtac atccgcctcg tggtcacgcg cggaagtggg      300

gacctggggc tgaatccata caactgcgcg aaggcccgcg tcttcatcat cgcggagcag      360

ctctcgatgt ttccaaaggc gctgtacgag cagggcattc gcgccatcac ggctgcaacg      420

cgccgcacgc ggggcgacgt gctcaatccg aagatcaagt ctctcaatta tctcaacaat      480

attctgatta aaatggaagc cattcatgca ggtgccaatg aagcgattgt gctcaaccac      540

gagggctatg tggtggaggg ttccggcgag aacatcttcc tcgtgcgcga tggcgtcctc      600

atcaccccgc cggcttatct cggggccctc gagggcatca cgcgccaggc ggtcatcgac      660

ttggctcctg cgctcggcct cgaggttcga caggaaccgt tcacccagca cgacgtgtac      720

gtggcggacg aggtgtttct cacaggcaca gccgcggaga ttgtcccggt ggtcgaggtg      780

gaccggcgcg ccattggtca cggcgttcca gggccggtga cgaagcgggt gcacgcggcg      840

ttccaggaaa tcgtgcgcgc ggacggcgtg cgcatcgaag gggctcgcgt ctga            894


<210>   139
<211>   286
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   139
Ile Phe Leu Asn Gly Glu Phe Val Thr Lys Glu Asn Ala Lys Ile Ser 
                5                   10                  15      

Val Tyr Asp His Gly Phe Leu Tyr Gly Asp Gly Val Phe Glu Gly Ile 
            20                  25                  30          

Arg Val Tyr Ser Gly Asn Val Phe Arg Leu Glu Glu His Ile Asp Arg 
        35                  40                  45              

Leu Tyr Asn Ser Ala Lys Ser Ile Met Leu Asn Ile Pro Tyr Thr Lys 
    50                  55                  60                  

Asp Glu Met Ile Asn His Val Leu Glu Thr Val Arg Arg Asn Gly Tyr 
65                  70                  75                  80  

Gln Asp Ala Tyr Ile Arg Leu Val Val Ser Arg Gly Val Gly Asp Leu 
                85                  90                  95      

Gly Leu Asp Pro Tyr Lys Cys Lys Ser Pro Gln Val Val Ile Ile Val 
            100                 105                 110         

Glu Pro Leu Ala Leu Phe Pro Lys His Leu Tyr Glu Thr Gly Ile Glu 
        115                 120                 125             

Val Val Thr Val Ala Thr Arg Arg Asn Arg Ser Asp Val Leu Ser Pro 
    130                 135                 140                 

Lys Val Lys Ser Leu Asn Tyr Leu Asn Asn Val Leu Val Lys Ile Glu 
145                 150                 155                 160 

Ala His Leu Ala Asn Val Ser Glu Ala Leu Ile Leu Asn Asp Gln Gly 
                165                 170                 175     

Tyr Val Ala Glu Gly Ser Gly Asp Asn Ile Phe Ile Val Lys Asn Gly 
            180                 185                 190         

Val Val Tyr Thr Pro Pro Gly Tyr Val Gly Ala Leu Glu Gly Ile Thr 
        195                 200                 205             

Arg Gln Ala Ile Ile Glu Ile Ala Glu Glu Leu Gly Tyr Thr Val Lys 
    210                 215                 220                 

Glu Glu Pro Phe Thr Arg His Asp Val Tyr Val Ala Asp Glu Val Phe 
225                 230                 235                 240 

Leu Thr Gly Thr Ala Ala Glu Val Ile Ser Val Ile Lys Val Asp Gly 
                245                 250                 255     

Arg Thr Ile Gly Asp Gly Thr Pro Gly Pro His Thr Lys Arg Leu Leu 
            260                 265                 270         

Glu Glu Phe Arg Arg Arg Val Ile Ala Glu Gly Val Lys Val 
        275                 280                 285     

<210>   140
<211>   286
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   140
Ile Phe Leu Asn Gly Glu Phe Val Thr Lys Glu Asn Ala Lys Ile Ser 
                5                   10                  15      

Val Tyr Asp His Gly Phe Leu Tyr Gly Asp Gly Val Phe Glu Gly Ile 
            20                  25                  30          

Arg Val Tyr Ser Gly Asn Val Phe Arg Leu Glu Glu His Ile Asp Arg 
        35                  40                  45              

Leu Tyr Asn Ser Ala Lys Ser Ile Leu Leu Asp Ile Pro Tyr Thr Lys 
    50                  55                  60                  

Glu Glu Met Ile Gly His Val Leu Glu Thr Ile Arg Arg Asn Gly Tyr 
65                  70                  75                  80  

Gln Asp Ala Tyr Ile Arg Leu Val Val Ser Arg Gly Val Gly Asp Leu 
                85                  90                  95      

Gly Leu Asp Pro Tyr Lys Cys Lys Thr Pro Gln Ile Val Ile Ile Val 
            100                 105                 110         

Glu Pro Leu Ala Leu Phe Pro Lys His Leu Tyr Glu Thr Gly Ile Glu 
        115                 120                 125             

Val Val Thr Val Ala Thr Arg Arg Asn Arg Ser Asp Val Leu Ser Pro 
    130                 135                 140                 

Lys Val Lys Ser Leu Asn Tyr Leu Asn Asn Val Leu Val Lys Ile Glu 
145                 150                 155                 160 

Ala His Leu Ala Asn Val Ser Glu Ala Leu Ile Leu Asn Asp Gln Gly 
                165                 170                 175     

Tyr Val Ala Glu Gly Ser Gly Asp Asn Val Phe Ile Ile Lys Asn Gly 
            180                 185                 190         

Val Ile Tyr Thr Pro Pro Gly Tyr Val Gly Ala Leu Glu Gly Ile Thr 
        195                 200                 205             

Arg Gln Ala Ile Ile Glu Ile Ala Glu Asp Leu Gly Tyr Thr Val Lys 
    210                 215                 220                 

Glu Glu Pro Phe Thr Arg His Asp Val Tyr Val Ala Asp Glu Val Phe 
225                 230                 235                 240 

Leu Thr Gly Thr Ala Ala Glu Val Ile Ser Val Ile Lys Val Asp Gly 
                245                 250                 255     

Arg Thr Ile Gly Asp Gly Thr Pro Gly Pro His Thr Lys Arg Leu Leu 
            260                 265                 270         

Glu Glu Phe Arg Arg Arg Val Val Val Glu Gly Val Lys Val 
        275                 280                 285     

<210>   141
<211>   286
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   141
Ile Phe Leu Asn Gly Glu Phe Val Thr Lys Glu Asn Ala Lys Ile Ser 
                5                   10                  15      

Val Tyr Asp His Gly Phe Leu Tyr Gly Asp Gly Ile Phe Glu Gly Ile 
            20                  25                  30          

Arg Val Tyr Ser Gly Asn Ile Phe Arg Met Lys Glu His Met Asp Arg 
        35                  40                  45              

Leu Tyr Arg Ser Ala Lys Ser Ile Leu Leu Thr Met Pro Tyr Thr Glu 
    50                  55                  60                  

Glu Glu Leu Thr Asp Ile Ile Val Ala Thr Val Glu Lys Asn Leu Tyr 
65                  70                  75                  80  

Glu Asp Ala Tyr Ile Arg Val Val Val Ser Arg Gly Val Gly Asp Leu 
                85                  90                  95      

Gly Leu Asp Pro Tyr Asn Cys Lys Lys Ala Asn Val Val Val Ile Val 
            100                 105                 110         

Glu Pro Leu Ser Ile Phe Pro Lys Glu Leu Tyr Glu Thr Gly Leu Glu 
        115                 120                 125             

Ile Val Thr Val Ala Thr Arg Arg Asn Arg Pro Asp Val Leu Ser Pro 
    130                 135                 140                 

Lys Val Lys Ser Leu Asn Tyr Leu Asn Asn Val Leu Val Arg Ile Glu 
145                 150                 155                 160 

Ala Arg Leu Ala Asn Val Ser Glu Ala Leu Met Leu Asn Asp Gln Gly 
                165                 170                 175     

Tyr Val Ala Glu Gly Ser Ala Asp Asn Val Phe Ile Ile Lys Asp Lys 
            180                 185                 190         

Cys Phe Tyr Thr Pro Pro Gly Tyr Val Gly Ala Leu Glu Gly Ile Thr 
        195                 200                 205             

Arg Asn Ala Val Met Glu Ile Ala Arg Glu Leu Gly Tyr Glu Val Lys 
    210                 215                 220                 

Glu Glu Pro Phe Thr Arg His Asp Val Tyr Thr Ala Asp Glu Val Phe 
225                 230                 235                 240 

Leu Thr Gly Thr Ala Ala Glu Val Ile Ala Val Val Lys Val Asp Gly 
                245                 250                 255     

Arg Thr Ile Gly Glu Gly Tyr Pro Gly Ala His Thr Lys Glu Leu Leu 
            260                 265                 270         

Val Lys Phe Arg Glu Arg Val Val Ser Glu Gly Val Lys Val 
        275                 280                 285     

<210>   142
<211>   288
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   142
Ile Tyr Met Asn Gly Glu Leu Val Glu Lys Glu Lys Ala Val Val Ser 
                5                   10                  15      

Val Tyr Asp His Gly Phe Leu Tyr Gly Asp Gly Val Phe Glu Gly Ile 
            20                  25                  30          

Arg Ser Tyr Gly Gly Asn Val Phe Cys Leu Lys Glu His Val Lys Arg 
        35                  40                  45              

Leu Tyr Glu Ser Ala Lys Ser Ile Leu Leu Thr Ile Pro Met Thr Val 
    50                  55                  60                  

Glu Glu Met Glu Lys Ala Val Val Gln Thr Leu Gln Lys Asn Gly Tyr 
65                  70                  75                  80  

Ala Asp Ala Tyr Ile Arg Leu Ile Val Ser Arg Gly Lys Gly Asp Leu 
                85                  90                  95      

Gly Leu Asp Pro Arg Ser Cys Glu Lys Pro Ser Val Ile Ile Ile Ala 
            100                 105                 110         

Glu Gln Leu Lys Leu Phe Pro Gln Glu Phe Tyr Asp Asn Gly Leu Ser 
        115                 120                 125             

Val Val Ser Val Ala Ser Arg Arg Asn Met Pro Asp Ala Leu Asp Pro 
    130                 135                 140                 

Arg Ile Lys Ser Met Asn Tyr Leu Asn Asn Val Leu Val Lys Ile Glu 
145                 150                 155                 160 

Ala Ala Gln Ala Gly Ala Leu Glu Ala Leu Met Leu Asn Gln Gln Gly 
                165                 170                 175     

Tyr Val Cys Glu Gly Ser Gly Asp Asn Val Phe Val Val Lys Asp Gly 
            180                 185                 190         

Lys Val Val Thr Pro Pro Ser Tyr Leu Gly Ala Leu Glu Gly Val Thr 
        195                 200                 205             

Arg Asn Ser Val Ile Glu Leu Cys Asp Lys Leu Gly Ile Pro Cys Glu 
    210                 215                 220                 

Glu Arg Pro Phe Thr Arg His Asp Val Tyr Val Ala Asp Glu Val Phe 
225                 230                 235                 240 

Leu Thr Gly Thr Ala Ala Glu Leu Ile Pro Val Val Lys Val Asp Ala 
                245                 250                 255     

Arg Glu Ile Gly Asp Gly Lys Pro Gly Glu Val Thr Lys Gln Leu Thr 
            260                 265                 270         

Glu Ala Phe Lys Arg Leu Thr Arg Glu Arg Gly Val Arg Val Pro Gly 
        275                 280                 285             

<210>   143
<211>   286
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   143
Ile Phe Leu Asn Asp Lys Leu Val Lys Lys Glu Asp Ala Lys Ile Ser 
                5                   10                  15      

Val Tyr Asp His Gly Phe Leu Tyr Gly Asp Gly Val Phe Glu Gly Ile 
            20                  25                  30          

Arg Val Tyr Asp Gly Asn Ile Phe Arg Met Gln Glu His Met Asp Arg 
        35                  40                  45              

Leu Tyr Asp Ser Ala Arg Ser Ile Met Leu Glu Ile Pro Tyr Pro Gln 
    50                  55                  60                  

Glu Glu Leu Thr Gln His Val Leu Lys Thr Val Glu Lys Asn Gly Leu 
65                  70                  75                  80  

Lys Asp Ala Tyr Ile Arg Leu Val Val Ser Arg Gly Ala Gly Asp Leu 
                85                  90                  95      

Gly Leu Asp Pro Asn Asn Cys Ser Asn Pro Ser Val Ile Ile Ile Val 
            100                 105                 110         

Glu Pro Leu Ala Ile Phe Pro Lys His Leu Tyr Glu Thr Gly Ile Asp 
        115                 120                 125             

Ile Val Thr Val Pro Thr Arg Arg Asn Arg Pro Asp Val Leu Ser Pro 
    130                 135                 140                 

Lys Val Lys Ser Leu Asn Tyr Leu Asn Asn Ile Leu Val Arg Ile Glu 
145                 150                 155                 160 

Ala His Met Ala Gly Val Thr Glu Ala Leu Met Leu Asn Asp Gln Gly 
                165                 170                 175     

Tyr Val Ala Glu Gly Ser Ala Asp Asn Val Phe Ile Tyr Lys Asn Gly 
            180                 185                 190         

Lys Leu Leu Thr Pro Pro Gly Tyr Ile Gly Ala Leu Glu Gly Ile Thr 
        195                 200                 205             

Arg Asn Ala Ile Ile Glu Ile Ala Arg Glu Leu Gly Tyr Glu Val Lys 
    210                 215                 220                 

Glu Glu Pro Phe Thr Arg His Asp Val Tyr Thr Ala Glu Glu Val Phe 
225                 230                 235                 240 

Leu Thr Gly Thr Ala Ala Glu Val Ile Ala Val Val Lys Val Asp Gly 
                245                 250                 255     

Arg Lys Ile Gly Asp Gly Lys Pro Gly Val His Thr Asn Arg Met Leu 
            260                 265                 270         

Glu Lys Phe Arg Glu Arg Val Val Arg Glu Gly Leu Lys Val 
        275                 280                 285     

<210>   144
<211>   297
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   144
Met Asp Val Ala Ser Gln Val Phe Leu Asp Gly Glu Phe Val Ser Ser 
                5                   10                  15      

Asp Ala Ala Ser Val Ser Val Phe Asp His Gly Leu Leu Tyr Gly Asp 
            20                  25                  30          

Gly Val Phe Glu Gly Ile Arg Ala Tyr Asp Gly Asn Val Phe Arg Leu 
        35                  40                  45              

Lys Pro His Met Asp Arg Leu Tyr Arg Ser Ala Lys Ser Ile Leu Leu 
    50                  55                  60                  

Glu Ile Pro Tyr Thr Asn Asp Glu Leu Thr Glu Leu Val Cys Glu Thr 
65                  70                  75                  80  

Val Arg Arg Asn His Leu Ser Ser Ala Tyr Ile Arg Leu Val Val Thr 
                85                  90                  95      

Arg Gly Ser Gly Asp Leu Gly Leu Asn Pro Tyr Asn Cys Ala Lys Ala 
            100                 105                 110         

Arg Val Phe Ile Ile Ala Glu Gln Leu Ser Met Phe Pro Lys Ala Leu 
        115                 120                 125             

Tyr Glu Gln Gly Ile Arg Ala Ile Thr Ala Ala Thr Arg Arg Thr Arg 
    130                 135                 140                 

Gly Asp Val Leu Asn Pro Lys Ile Lys Ser Leu Asn Tyr Leu Asn Asn 
145                 150                 155                 160 

Ile Leu Ile Lys Met Glu Ala Ile His Ala Gly Ala Asn Glu Ala Ile 
                165                 170                 175     

Val Leu Asn His Glu Gly Tyr Val Val Glu Gly Ser Gly Glu Asn Ile 
            180                 185                 190         

Phe Leu Val Arg Asp Gly Val Leu Ile Thr Pro Pro Ala Tyr Leu Gly 
        195                 200                 205             

Ala Leu Glu Gly Ile Thr Arg Gln Ala Val Ile Asp Leu Ala Pro Ala 
    210                 215                 220                 

Leu Gly Leu Glu Val Arg Gln Glu Pro Phe Thr Gln His Asp Val Tyr 
225                 230                 235                 240 

Val Ala Asp Glu Val Phe Leu Thr Gly Thr Ala Ala Glu Ile Val Pro 
                245                 250                 255     

Val Val Glu Val Asp Arg Arg Ala Ile Gly His Gly Val Pro Gly Pro 
            260                 265                 270         

Val Thr Lys Arg Val His Ala Ala Phe Gln Glu Ile Val Arg Ala Asp 
        275                 280                 285             

Gly Val Arg Ile Glu Gly Ala Arg Val 
    290                 295         

<210>   145
<211>   297
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   145
Met Asp Val Ala Ser Gln Val Phe Leu Asp Gly Glu Phe Val Ser Ser 
                5                   10                  15      

Asp Ala Ala Ser Val Ser Val Phe Asp His Gly Leu Leu Tyr Gly Asp 
            20                  25                  30          

Gly Val Phe Glu Gly Ile Arg Ala Tyr Asp Gly Asn Val Phe Arg Leu 
        35                  40                  45              

Lys Pro His Met Asp Arg Leu Tyr Lys Ser Ala Lys Ser Ile Leu Leu 
    50                  55                  60                  

Glu Ile Pro Tyr Thr Gln Asp Glu Leu Thr Glu Leu Val Cys Glu Thr 
65                  70                  75                  80  

Val Arg Arg Asn His Leu Ser Ser Ala Tyr Ile Arg Leu Val Val Thr 
                85                  90                  95      

Arg Gly Ser Gly Asp Leu Gly Leu Asn Pro Tyr Asn Cys Ala Lys Ala 
            100                 105                 110         

Arg Val Phe Ile Ile Ala Glu Gln Leu Ser Met Phe Pro Lys Ala Leu 
        115                 120                 125             

Tyr Glu Gln Gly Ile Arg Ala Ile Thr Ala Ala Thr Arg Arg Thr Arg 
    130                 135                 140                 

Gly Asp Val Leu Asn Pro Lys Ile Lys Ser Leu Asn Tyr Leu Asn Asn 
145                 150                 155                 160 

Ile Leu Ile Lys Met Glu Ala Ile His Ala Gly Ala Asn Glu Ala Ile 
                165                 170                 175     

Val Leu Asn His Glu Gly Tyr Val Val Glu Gly Ser Gly Glu Asn Ile 
            180                 185                 190         

Phe Leu Val Arg Asp Gly Val Leu Ile Thr Pro Pro Ala Tyr Leu Gly 
        195                 200                 205             

Ala Leu Glu Gly Ile Thr Arg Gln Ala Val Ile Asp Leu Ala Pro Ala 
    210                 215                 220                 

Leu Gly Leu Glu Val Arg Gln Glu Pro Phe Thr Gln His Asp Val Tyr 
225                 230                 235                 240 

Val Ala Asp Glu Val Phe Leu Thr Gly Thr Ala Ala Glu Ile Val Pro 
                245                 250                 255     

Val Val Glu Val Asp Arg Arg Ala Ile Gly His Gly Val Pro Gly Pro 
            260                 265                 270         

Val Thr Lys Arg Val His Ala Ala Phe Gln Glu Ile Val Arg Ala Asp 
        275                 280                 285             

Gly Val Arg Ile Glu Gly Ala Arg Val 
    290                 295         

<210>   146
<211>   297
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   146
Met Asp Val Ala Ser Gln Val Phe Leu Asp Gly Glu Phe Val Ser Ser 
                5                   10                  15      

Asp Ala Ala Ser Val Ser Val Phe Asp His Gly Leu Leu Tyr Gly Asp 
            20                  25                  30          

Gly Val Phe Glu Gly Ile Arg Ala Tyr Asp Gly Asn Val Phe Arg Leu 
        35                  40                  45              

Lys Pro His Met Asp Arg Leu Tyr Arg Ser Ala Lys Ser Ile Leu Leu 
    50                  55                  60                  

Glu Ile Pro Tyr Thr Gln Asp Glu Leu Thr Glu Leu Val Cys Glu Thr 
65                  70                  75                  80  

Val Arg Arg Asn His Leu Ser Ser Ala Tyr Ile Arg Leu Val Val Thr 
                85                  90                  95      

Arg Gly Ser Gly Asp Leu Gly Leu Asn Pro Tyr Asn Cys Ala Lys Ala 
            100                 105                 110         

Arg Val Phe Ile Ile Ala Glu Gln Leu Ser Met Phe Pro Lys Ala Leu 
        115                 120                 125             

Tyr Glu Gln Gly Ile Arg Ala Ile Thr Ala Ala Thr Arg Arg Thr Arg 
    130                 135                 140                 

Gly Asp Val Leu Asn Pro Lys Ile Lys Ser Leu Asn Tyr Leu Asn Asn 
145                 150                 155                 160 

Ile Leu Ile Lys Met Glu Ala Ile His Ala Gly Ala Asn Glu Ala Ile 
                165                 170                 175     

Val Leu Asn His Glu Gly Tyr Val Val Glu Gly Ser Gly Glu Asn Ile 
            180                 185                 190         

Phe Leu Val Arg Asp Gly Val Leu Ile Thr Pro Pro Ala Tyr Leu Gly 
        195                 200                 205             

Ala Leu Glu Gly Ile Thr Arg Gln Ala Val Ile Asp Leu Ala Pro Ala 
    210                 215                 220                 

Leu Gly Ile Glu Val Arg Gln Glu Pro Phe Thr Gln His Asp Val Tyr 
225                 230                 235                 240 

Val Ala Asp Glu Val Phe Leu Thr Gly Thr Ala Ala Glu Ile Val Pro 
                245                 250                 255     

Val Val Glu Val Asp Arg Arg Ala Ile Gly His Gly Val Pro Gly Pro 
            260                 265                 270         

Val Thr Lys Arg Val His Ala Ala Phe Gln Glu Ile Val Arg Ala Asp 
        275                 280                 285             

Gly Val Arg Ile Glu Gly Ala Arg Val 
    290                 295         

<210>   147
<211>   297
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   147
Met Asp Val Ala Ser Gln Val Phe Leu Asp Gly Glu Phe Val Ser Ser 
                5                   10                  15      

Asp Ala Ala Ser Val Ser Val Phe Asp His Gly Leu Leu Tyr Gly Asp 
            20                  25                  30          

Gly Val Phe Glu Gly Ile Arg Ala Tyr Asp Gly Asn Val Phe Arg Leu 
        35                  40                  45              

Lys Pro His Met Asp Arg Leu Tyr Arg Ser Ala Lys Ser Ile Leu Leu 
    50                  55                  60                  

Glu Ile Pro Tyr Thr Gln Asp Glu Leu Thr Glu Leu Val Cys Glu Thr 
65                  70                  75                  80  

Val Arg Arg Asn His Leu Ser Ser Ala Tyr Ile Arg Leu Val Val Thr 
                85                  90                  95      

Arg Gly Ser Gly Asp Leu Gly Leu Asn Pro Tyr Asn Cys Ala Lys Ala 
            100                 105                 110         

Arg Val Phe Ile Ile Ala Glu Gln Leu Ser Met Phe Pro Lys Ala Leu 
        115                 120                 125             

Tyr Glu Gln Gly Ile Arg Ala Ile Thr Ala Ala Thr Arg Arg Thr Arg 
    130                 135                 140                 

Gly Asp Val Leu Asn Pro Lys Ile Lys Ser Leu Asn Tyr Leu Asn Asn 
145                 150                 155                 160 

Ile Leu Ile Lys Met Glu Ala Ile His Ala Gly Ala Asn Glu Ala Ile 
                165                 170                 175     

Val Leu Asn His Glu Gly Tyr Val Val Glu Gly Ser Gly Glu Asn Ile 
            180                 185                 190         

Phe Leu Val Arg Asp Gly Val Leu Ile Thr Pro Pro Ala Tyr Leu Gly 
        195                 200                 205             

Ala Leu Glu Gly Ile Thr Arg Gln Ala Val Ile Asp Leu Ala Pro Ala 
    210                 215                 220                 

Leu Gly Leu Glu Val Arg Gln Glu Pro Phe Thr Gln His Asp Val Tyr 
225                 230                 235                 240 

Val Ala Asp Glu Val Phe Leu Thr Gly Thr Ala Ala Glu Ile Val Pro 
                245                 250                 255     

Val Val Glu Val Asp Arg Arg Ala Ile Gly His Gly Val Pro Gly Pro 
            260                 265                 270         

Val Thr Lys Arg Val His Ala Ala Phe Gln Glu Ile Val Arg Ala Asp 
        275                 280                 285             

Gly Val Arg Ile Glu Gly Ala Arg Ile 
    290                 295         

<210>   148
<211>   297
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   148
Met Asp Val Ala Ser Gln Val Phe Leu Asp Gly Glu Phe Val Ser Ser 
                5                   10                  15      

Asp Ala Ala Ser Val Ser Val Phe Asp His Gly Leu Leu Tyr Gly Asp 
            20                  25                  30          

Gly Val Phe Glu Gly Ile Arg Ala Tyr Asp Gly Asn Val Phe Arg Leu 
        35                  40                  45              

Lys Pro His Met Asp Arg Leu Tyr Arg Ser Ala Lys Ser Ile Leu Leu 
    50                  55                  60                  

Glu Ile Pro Tyr Thr Gln Asp Glu Leu Thr Glu Leu Val Cys Glu Thr 
65                  70                  75                  80  

Val Arg Arg Asn His Leu Ser Ser Ala Tyr Ile Arg Leu Val Val Thr 
                85                  90                  95      

Arg Gly Ser Gly Asp Leu Gly Leu Asn Pro Tyr Asn Cys Ala Lys Ala 
            100                 105                 110         

Arg Val Phe Ile Ile Ala Glu Gln Leu Ser Met Phe Pro Lys Ala Leu 
        115                 120                 125             

Tyr Glu Gln Gly Ile Arg Ala Ile Thr Ala Ala Thr Arg Arg Thr Arg 
    130                 135                 140                 

Gly Asp Val Leu Asn Pro Lys Ile Lys Ser Leu Asn Tyr Leu Asn Asn 
145                 150                 155                 160 

Ile Leu Ile Lys Met Glu Ala Ile His Ala Gly Ala Asn Glu Ala Ile 
                165                 170                 175     

Val Leu Asn His Glu Gly Tyr Val Val Glu Gly Ser Gly Glu Asn Ile 
            180                 185                 190         

Phe Leu Val Arg Asp Gly Val Leu Ile Thr Pro Pro Ala Tyr Leu Gly 
        195                 200                 205             

Ala Leu Glu Gly Ile Thr Arg Gln Ala Val Ile Asp Leu Ala Pro Ala 
    210                 215                 220                 

Leu Gly Leu Glu Val Arg Gln Glu Pro Phe Thr Gln His Asp Val Tyr 
225                 230                 235                 240 

Val Ala Asp Glu Val Phe Leu Thr Gly Thr Ala Ala Glu Ile Val Pro 
                245                 250                 255     

Val Val Glu Val Asp Arg Arg Ala Ile Gly His Gly Val Pro Gly Pro 
            260                 265                 270         

Val Thr Lys Arg Val His Ala Ala Phe Gln Glu Ile Val Arg Ala Glu 
        275                 280                 285             

Gly Val Arg Ile Glu Gly Ala Arg Val 
    290                 295         

<210>   149
<211>   894
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   149
ttggacgtgg catcacaggt ttttcttgac ggcgaatttg tctccagcga cgcagccagc       60

gtgtcagtgt tcgatcacgg cctcctgtac ggcgatggcg tcttcgaagg aatccgcgca      120

tatgacggga acgtattccg cctcaagccg cacatggacc gactttatcg ttcggccaag      180

tccattcttc tcgagattcc gtatacgaat gacgaattga cggaactcgt gtgcgagacc      240

gtccggcgca atcatctgtc ctcggcgtac atccgcctcg tggtcacgcg cggaagtggg      300

gacctggggc tgaatccata caactgcgcg aaggcccgcg tcttcatcat cgcggagcag      360

ctctcgatgt ttccaaaggc gctgtacgag cagggcattc gcgccatcac ggctgcaacg      420

cgccgcacgc ggggcgacgt gctcaatccg aagatcaagt ctctcaatta tctcaacaat      480

attctgatta aaatggaagc cattcatgca ggtgccaatg aagcgattgt gctcaaccac      540

gagggctatg tggtggaggg ttccggcgag aacatcttcc tcgtgcgcga tggcgtcctc      600

atcaccccgc cggcttatct cggggccctc gagggcatca cgcgccaggc ggtcatcgac      660

ttggctcctg cgctcggcct cgaggttcga caggaaccgt tcacccagca cgacgtgtac      720

gtggcggacg aggtgtttct cacaggcaca gccgcggaga ttgtcccggt ggtcgaggtg      780

gaccggcgcg ccattggtca cggcgttcca gggccggtga cgaagcgggt gcacgcggcg      840

ttccaggaaa tcgtgcgcgc ggacggcgtg cgcatcgaag gggctcgcgt ctga            894


<210>   150
<211>   894
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   150
ttggacgtgg catcacaggt ttttcttgac ggcgaatttg tctccagcga cgcagccagc       60

gtgtcagtgt tcgatcacgg cctcctgtac ggcgatggcg tcttcgaagg aatccgcgca      120

tatgacggga acgtattccg cctcaagccg cacatggacc gactttataa atcggccaag      180

tccattcttc tcgagattcc gtatacgcag gacgaattga cggaactcgt gtgcgagacc      240

gtccggcgca atcatctgtc ctcggcgtac atccgcctcg tggtcacgcg cggaagtggg      300

gacctggggc tgaatccata caactgcgcg aaggcccgcg tcttcatcat cgcggagcag      360

ctctcgatgt ttccaaaggc gctgtacgag cagggcattc gcgccatcac ggctgcaacg      420

cgccgcacgc ggggcgacgt gctcaatccg aagatcaagt ctctcaatta tctcaacaat      480

attctgatta aaatggaagc cattcatgca ggtgccaatg aagcgattgt gctcaaccac      540

gagggctatg tggtggaggg ttccggcgag aacatcttcc tcgtgcgcga tggcgtcctc      600

atcaccccgc cggcttatct cggggccctc gagggcatca cgcgccaggc ggtcatcgac      660

ttggctcctg cgctcggcct cgaggttcga caggaaccgt tcacccagca cgacgtgtac      720

gtggcggacg aggtgtttct cacaggcaca gccgcggaga ttgtcccggt ggtcgaggtg      780

gaccggcgcg ccattggtca cggcgttcca gggccggtga cgaagcgggt gcacgcggcg      840

ttccaggaaa tcgtgcgcgc ggacggcgtg cgcatcgaag gggctcgcgt ctga            894


<210>   151
<211>   894
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   151
ttggacgtgg catcacaggt ttttcttgac ggcgaatttg tctccagcga cgcagccagc       60

gtgtcagtgt tcgatcacgg cctcctgtac ggcgatggcg tcttcgaagg aatccgcgca      120

tatgacggga acgtattccg cctcaagccg cacatggacc gactttatcg ttcggccaag      180

tccattcttc tcgagattcc gtatacgcag gacgaattga cggaactcgt gtgcgagacc      240

gtccggcgca atcatctgtc ctcggcgtac atccgcctcg tggtcacgcg cggaagtggg      300

gacctggggc tgaatccata caactgcgcg aaggcccgcg tcttcatcat cgcggagcag      360

ctctcgatgt ttccaaaggc gctgtacgag cagggcattc gcgccatcac ggctgcaacg      420

cgccgcacgc ggggcgacgt gctcaatccg aagatcaagt ctctcaatta tctcaacaat      480

attctgatta aaatggaagc cattcatgca ggtgccaatg aagcgattgt gctcaaccac      540

gagggctatg tggtggaggg ttccggcgag aacatcttcc tcgtgcgcga tggcgtcctc      600

atcaccccgc cggcttatct cggggccctc gagggcatca cgcgccaggc ggtcatcgac      660

ttggctcctg cgctcggcat tgaggttcga caggaaccgt tcacccagca cgacgtgtac      720

gtggcggacg aggtgtttct cacaggcaca gccgcggaga ttgtcccggt ggtcgaggtg      780

gaccggcgcg ccattggtca cggcgttcca gggccggtga cgaagcgggt gcacgcggcg      840

ttccaggaaa tcgtgcgcgc ggacggcgtg cgcatcgaag gggctcgcgt ctga            894


<210>   152
<211>   894
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   152
ttggacgtgg catcacaggt ttttcttgac ggcgaatttg tctccagcga cgcagccagc       60

gtgtcagtgt tcgatcacgg cctcctgtac ggcgatggcg tcttcgaagg aatccgcgca      120

tatgacggga acgtattccg cctcaagccg cacatggacc gactttatcg ttcggccaag      180

tccattcttc tcgagattcc gtatacgcag gacgaattga cggaactcgt gtgcgagacc      240

gtccggcgca atcatctgtc ctcggcgtac atccgcctcg tggtcacgcg cggaagtggg      300

gacctggggc tgaatccata caactgcgcg aaggcccgcg tcttcatcat cgcggagcag      360

ctctcgatgt ttccaaaggc gctgtacgag cagggcattc gcgccatcac ggctgcaacg      420

cgccgcacgc ggggcgacgt gctcaatccg aagatcaagt ctctcaatta tctcaacaat      480

attctgatta aaatggaagc cattcatgca ggtgccaatg aagcgattgt gctcaaccac      540

gagggctatg tggtggaggg ttccggcgag aacatcttcc tcgtgcgcga tggcgtcctc      600

atcaccccgc cggcttatct cggggccctc gagggcatca cgcgccaggc ggtcatcgac      660

ttggctcctg cgctcggcct cgaggttcga caggaaccgt tcacccagca cgacgtgtac      720

gtggcggacg aggtgtttct cacaggcaca gccgcggaga ttgtcccggt ggtcgaggtg      780

gaccggcgcg ccattggtca cggcgttcca gggccggtga cgaagcgggt gcacgcggcg      840

ttccaggaaa tcgtgcgcgc ggacggcgtg cgcatcgaag gggctcgcat ttga            894


<210>   153
<211>   894
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   153
ttggacgtgg catcacaggt ttttcttgac ggcgaatttg tctccagcga cgcagccagc       60

gtgtcagtgt tcgatcacgg cctcctgtac ggcgatggcg tcttcgaagg aatccgcgca      120

tatgacggga acgtattccg cctcaagccg cacatggacc gactttatcg ttcggccaag      180

tccattcttc tcgagattcc gtatacgcag gacgaattga cggaactcgt gtgcgagacc      240

gtccggcgca atcatctgtc ctcggcgtac atccgcctcg tggtcacgcg cggaagtggg      300

gacctggggc tgaatccata caactgcgcg aaggcccgcg tcttcatcat cgcggagcag      360

ctctcgatgt ttccaaaggc gctgtacgag cagggcattc gcgccatcac ggctgcaacg      420

cgccgcacgc ggggcgacgt gctcaatccg aagatcaagt ctctcaatta tctcaacaat      480

attctgatta aaatggaagc cattcatgca ggtgccaatg aagcgattgt gctcaaccac      540

gagggctatg tggtggaggg ttccggcgag aacatcttcc tcgtgcgcga tggcgtcctc      600

atcaccccgc cggcttatct cggggccctc gagggcatca cgcgccaggc ggtcatcgac      660

ttggctcctg cgctcggcct cgaggttcga caggaaccgt tcacccagca cgacgtgtac      720

gtggcggacg aggtgtttct cacaggcaca gccgcggaga ttgtcccggt ggtcgaggtg      780

gaccggcgcg ccattggtca cggcgttcca gggccggtga cgaagcgggt gcacgcggcg      840

ttccaggaaa tcgtgcgcgc ggaaggcgtg cgcatcgaag gggctcgcgt ctga            894


<210>   154
<211>   557
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   154
Met Arg Ser Asp Met Ile Lys Lys Gly Val Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ala Leu Leu Tyr Ala Thr Gly Val Lys Pro Arg Asp Leu Ser Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Val Asp Ile Val Pro Gly His Val 
        35                  40                  45              

His Leu Arg Glu Phe Ala Glu Val Val Lys Asp Ala Ile Arg Gln Ala 
    50                  55                  60                  

Gly Gly Val Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Ala Ser Arg Glu Leu 
                85                  90                  95      

Ile Ala Asp Ser Ala Glu Thr Met Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Phe Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ala Val Arg Cys Asn Val Pro Ala Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Arg Ser Arg Thr Gly Arg Pro Leu Ser Leu Ser Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Gln Tyr Met Ser Gly Gln Ile Ser Glu Asp 
                165                 170                 175     

Asp Leu Leu Asp Leu Glu Arg Asn Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Ile Met Glu Met Leu 
        195                 200                 205             

Gly Ile Ala Leu Pro Gly Asn Gly Thr Leu Val Ala Thr Ser Lys Glu 
    210                 215                 220                 

Arg His Glu Leu Ile Tyr Glu Ala Ala Lys His Leu Ile Arg Met Val 
225                 230                 235                 240 

Glu Gln Asp Ile Arg Pro Arg Asp Ile Ile Thr Arg Glu Ala Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Leu Met Ala Ile Ala His Glu Ala Gly Ile Asp Tyr Ser Leu 
        275                 280                 285             

Ser Asp Ile Asn Glu Ile Ala Lys Arg Val Pro Tyr Leu Ala Lys Ile 
    290                 295                 300                 

Ser Pro Ala Ser Glu Tyr Ser Ile Gln Asp Val His Arg Ala Gly Gly 
305                 310                 315                 320 

Val Ser Ala Ile Ile Arg Glu Leu Cys Glu His Thr Asp Ala Val His 
                325                 330                 335     

Pro Asp Arg Ile Thr Val Thr Gly Lys Thr Leu Tyr Glu Gln Val Lys 
            340                 345                 350         

Asp Ala Lys Ile Leu Asp Glu Arg Val Ile Arg Pro Ala Ser Asn Pro 
        355                 360                 365             

Tyr Ser Arg Glu Gly Gly Leu Ser Ile Leu Phe Gly Asn Leu Ala Pro 
    370                 375                 380                 

Asp Gly Ala Val Leu Lys Val Gly Ala Val Asp Pro Asp Ile Gln Arg 
385                 390                 395                 400 

Phe Val Gly Arg Ala Ile Cys Phe Asn Ser Gln Asp Glu Ala Met Glu 
                405                 410                 415     

Gly Ile Asn Ser Gly Lys Val Gln Pro Gly His Val Val Val Ile Arg 
            420                 425                 430         

Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro 
        435                 440                 445             

Thr Ser Ser Ile Val Gly Arg Gly Leu Gly Arg Glu Val Ala Leu Ile 
    450                 455                 460                 

Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Ile Cys Val Gly His 
465                 470                 475                 480 

Ile Ser Pro Glu Ala Gly Val Gly Gly Pro Ile Ala Leu Val Glu Asp 
                485                 490                 495     

Gly Asp Glu Ile Glu Ile Asp Ile Pro Asn Arg Ala Ile Thr Leu Lys 
            500                 505                 510         

Val Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Arg Tyr Gln Pro Pro 
        515                 520                 525             

Ala Lys Glu Lys Leu Thr Gly Tyr Leu Ala Arg Tyr Gln Lys Leu Val 
    530                 535                 540                 

Thr Ser Ala Asn Thr Gly Ala Val Leu Thr Val Asp Ala 
545                 550                 555         

<210>   155
<211>   1674
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   155
atgagaagcg acatgatcaa aaagggcgtg gaccgggcgc cgcacagggc cctgctctat       60

gccacgggcg tcaaacccag ggatctgtcc aaaccgttta tcggcgtgtg caactcgtac      120

gtcgacatcg ttccgggcca cgttcatctc cgcgaattcg cggaagtcgt gaaagatgcc      180

atccgccagg caggtggcgt cccgttcgaa ttcaacacca tcggtgtgga cgacgggatc      240

gccatggggc acatcggcat gcggtattcg ctcgcgagcc gcgagctcat cgccgattcg      300

gccgagacga tgatcaacgc ccactggttc gacggcgtct ttttcatccc caactgtgac      360

aagatcacgc ccggcatgct catggcggcc gtgcgctgca acgtgccggc ggtcttcgtc      420

tccggcggcc cgatggaggc cgggaggtcg cgcacgggtc gtccgctttc cctcagctcg      480

gtcttcgaag gcgtgggcca gtacatgagc gggcaaatct ccgaagatga cctgctggat      540

ctggagcgga acgcgtgtcc cacgtgtggc tcgtgttctg gcatgttcac cgccaactcc      600

atgaactgca tcatggagat gctggggatt gcgctccccg gcaatggcac gctggtcgcc      660

acgtccaagg agcggcacga gctgatttat gaggccgcca aacacctcat tcgcatggtg      720

gagcaggaca ttcggccgcg cgacatcatc acccgcgaag ccattgatga cgcgttcgcg      780

ctggatatgg ccatgggcgg atcgaccaac acggttctgc acctgatggc catcgcgcat      840

gaggcgggca tcgactattc cctgagcgat atcaacgaaa ttgccaaaag agtgccgtat      900

ctcgcgaaga ttagtcccgc gtccgagtac agcatccagg acgtgcaccg cgcgggcggc      960

gtgtccgcca tcatccgcga gctgtgcgaa cacaccgacg cggttcaccc ggatcgcatc     1020

acggtgacgg gcaagacgct gtacgagcag gtcaaggacg cgaagatcct cgacgaacgc     1080

gtcatccgcc cggcttccaa cccgtacagc cgcgagggcg gtctgtccat cctgtttggc     1140

aatctcgcgc cggacggcgc ggtgctgaaa gtcggtgcgg tcgatcccga catccagcga     1200

ttcgtgggcc gcgccatctg cttcaattcg caggacgagg cgatggaggg catcaacagc     1260

ggcaaggtgc aaccgggtca cgtcgtggtc attcgctatg aagggccgaa gggcgggccg     1320

gggatgcccg agatgctggc gcccacgtcg tccatcgtgg gccggggcct cggccgcgag     1380

gtggccctta tcacggacgg ccggttttcg ggggccacgc gagggatttg cgtcggccat     1440

atctcgcccg aggccggcgt aggtgggccg attgcgctcg tcgaggatgg ggacgagatc     1500

gagatcgaca ttccgaatcg cgccatcacc ctgaaggtgt cggacgagga actggcagcg     1560

cgcagggcgc gatatcagcc gcccgcgaaa gaaaagctca cgggctacct cgctcgatat     1620

cagaagttgg tcacgtcggc gaacaccggt gctgttctga cggtggacgc atga           1674


<210>   156
<211>   555
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   156
Met Arg Ser Asp Met Ile Lys Lys Gly Ile Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ser Leu Leu Arg Ala Ala Gly Val Lys Glu Glu Glu Met Asp Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Ile Asp Ile Ile Pro Gly His Met 
        35                  40                  45              

His Leu Asn Lys Phe Ala Glu Val Ala Lys Glu Ala Ile Arg Glu Ala 
    50                  55                  60                  

Gly Gly Ile Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Pro Ser Arg Glu Ile 
                85                  90                  95      

Ile Cys Asp Ala Ala Glu Thr Val Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Phe Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ser Val Arg Thr Asn Val Pro Ser Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Arg Thr Lys Asp Gly Lys Asn Leu Ser Leu Ala Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Ala Phe Ser Ser Gly Lys Met Thr Arg Glu 
                165                 170                 175     

Glu Leu Leu Glu Ile Glu Gln Thr Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Ser Leu Met Glu Met Leu 
        195                 200                 205             

Gly Met Ala Leu Pro Gly Asn Gly Thr Ile Val Ala Thr Ser Glu Ala 
    210                 215                 220                 

Arg His Gln Leu Ile Lys Asp Ala Ala Lys His Leu Met Asn Leu Ile 
225                 230                 235                 240 

Glu Lys Asp Ile Arg Pro Arg Asp Ile Ile Thr Lys Glu Thr Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Thr Leu Ala Ile Ala Asn Glu Ala Glu Ile Glu Tyr Asp Leu 
        275                 280                 285             

Asn Arg Ile Asn Glu Val Ala Glu Arg Val Pro Tyr Leu Cys Lys Ile 
    290                 295                 300                 

Ser Pro Ala Ser Asp Tyr Ser Met Asp Asp Val His His Ala Gly Gly 
305                 310                 315                 320 

Val Ala Ala Ile Ile Lys Glu Leu Cys Glu Ile Asp Gly Ala Ile His 
                325                 330                 335     

Pro Asp Arg Ile Thr Ile Thr Gly Lys Ser Ile Tyr Glu Asn Val Lys 
            340                 345                 350         

Asp Ala Glu Ile Thr Asp Asp Val Val Ile Arg Arg Lys Asp Asn Pro 
        355                 360                 365             

Tyr Ser Pro Val Gly Gly Leu Ser Ile Leu Phe Gly Asn Leu Ala Pro 
    370                 375                 380                 

Asn Gly Ala Val Ile Lys Val Gly Ala Val Asp Pro Ser Ile Gln Ile 
385                 390                 395                 400 

Phe Glu Gly Glu Ala Ile Val Tyr Asn Ser Gln Glu Glu Ala Gln Gln 
                405                 410                 415     

Gly Ile Asn Asn Gly Asp Val Arg Glu Gly His Val Val Val Ile Arg 
            420                 425                 430         

Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro 
        435                 440                 445             

Thr Ser Ala Ile Ile Gly Arg Gly Leu Gly Thr Lys Val Ala Leu Ile 
    450                 455                 460                 

Thr Asp Gly Arg Phe Ser Gly Ala Ser Arg Gly Ile Ser Ile Gly His 
465                 470                 475                 480 

Ile Ser Pro Glu Ala Ala Glu Gly Gly Pro Ile Ala Phe Ile Glu Asn 
                485                 490                 495     

Gly Asp Lys Ile Arg Ile Asp Leu Pro Asn Arg Thr Ile Glu Trp Leu 
            500                 505                 510         

Val Ser Asp Glu Glu Ile Ala Lys Arg Gln Glu Gly Trp Thr Glu Pro 
        515                 520                 525             

Glu Pro Lys Val Lys Lys Gly Tyr Leu Ala Arg Tyr Ser Lys Leu Val 
    530                 535                 540                 

Thr Ser Ala Asn Thr Gly Gly Val Met Lys Ile 
545                 550                 555 

<210>   157
<211>   555
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   157
Met Arg Ser Asp Met Ile Lys Lys Gly Ile Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ser Leu Leu Tyr Ala Ala Gly Leu Lys Thr Glu Asp Phe Asp Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Ile Asp Ile Ile Pro Gly His Arg 
        35                  40                  45              

His Leu Asn Lys Phe Ala Glu Val Val Lys Glu Ala Ile Arg Glu Ala 
    50                  55                  60                  

Gly Gly Val Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Pro Ser Arg Glu Leu 
                85                  90                  95      

Ile Ala Asp Ser Ala Glu Thr Val Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Tyr Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ala Val Arg Thr Asn Val Pro Ala Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Met Ala Pro Asp Gly Lys Gln Leu Ser Leu Thr Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Ala His Lys Ser Gly Lys Ile Ser Tyr Glu 
                165                 170                 175     

Glu Leu Lys Met Leu Glu Thr Ser Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Ser Leu Met Glu Met Leu 
        195                 200                 205             

Gly Leu Thr Pro Pro Gly Asn Ala Thr Ile Val Ala Thr Ser Glu Glu 
    210                 215                 220                 

Arg His Arg Ile Ile Arg Glu Ala Val Gly His Leu Met Asn Cys Ile 
225                 230                 235                 240 

Lys Asn Asp Ile Arg Pro Arg Asp Ile Val Thr Glu Glu Ala Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Thr Leu Ala Ile Ala Arg Glu Ala Gly Ile Asp Tyr Asp Leu 
        275                 280                 285             

Glu Arg Ile Asn Lys Val Ala Glu Arg Val Pro Tyr Leu Ala Lys Ile 
    290                 295                 300                 

Met Pro Ala Ser Asp Tyr Ser Met His Asp Val His Leu Ala Gly Gly 
305                 310                 315                 320 

Ile Ser Ala Ile Val His Glu Leu Cys Lys Ile Glu Gly Ala Ile His 
                325                 330                 335     

Pro Gly Arg Leu Thr Ile Thr Gly Lys Ser Ile Tyr Glu Asn Val Lys 
            340                 345                 350         

Asp Ala Glu Ile Arg Asn Pro Glu Val Ile Arg Pro Lys Glu Asn Pro 
        355                 360                 365             

Tyr Ser Pro Val Gly Gly Leu Ser Ile Leu Tyr Gly Asn Ile Ala Pro 
    370                 375                 380                 

Asp Gly Ala Val Ile Lys Val Gly Ala Val Asp Pro Asp Ile His Thr 
385                 390                 395                 400 

Phe Thr Gly Glu Ala Ile Val Phe Glu Ser Gln Glu Glu Ala Gln Lys 
                405                 410                 415     

Gly Ile Asp Ser Gly Leu Val His Glu Gly His Val Val Val Ile Arg 
            420                 425                 430         

Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro 
        435                 440                 445             

Thr Ser Ser Ile Met Gly Arg Gly Leu Gly Lys Thr Val Ala Leu Ile 
    450                 455                 460                 

Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Ile Cys Val Gly His 
465                 470                 475                 480 

Ile Ser Pro Glu Ala Ala Glu Gly Gly Pro Ile Ala Leu Val Glu Asn 
                485                 490                 495     

Gly Asp Arg Ile Thr Ile Asp Leu Ile Asn Arg Arg Ile Glu Leu His 
            500                 505                 510         

Val Pro Asp Glu Glu Leu Gln Arg Arg Lys Gln Asn Trp Val Gln Pro 
        515                 520                 525             

Glu Pro Lys Ile Thr Ser Gly Tyr Leu Ala Arg Tyr Ser Ala Leu Val 
    530                 535                 540                 

Thr Ser Ala Asn Thr Gly Gly Val Leu Lys Ile 
545                 550                 555 

<210>   158
<211>   556
<212>   PRT
<213>   Bacillus sp. B14905

<400>   158
Met Arg Ser Asp Met Ile Lys Val Gly Val Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ser Leu Leu Tyr Ala Thr Gly Lys Val Lys Ala Lys Asp Leu Gly Lys 
            20                  25                  30          

Pro Phe Ile Gly Val Cys Asn Ser Tyr Ile Asp Ile Ile Pro Gly His 
        35                  40                  45              

Val His Leu Arg Thr Phe Ala Asp Val Val Lys Glu Ala Ile Ile Glu 
    50                  55                  60                  

Ala Gly Gly Ile Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly 
65                  70                  75                  80  

Ile Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Pro Ser Arg Glu 
                85                  90                  95      

Ile Ile Ala Asp Ser Ala Glu Thr Val Ile Asn Ala His Trp Phe Asp 
            100                 105                 110         

Gly Val Phe Tyr Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu 
        115                 120                 125             

Met Ala Ala Val Arg Thr Asn Val Pro Ser Ile Phe Val Ser Gly Gly 
    130                 135                 140                 

Pro Met Glu Ala Gly Thr Ser Ala Ser Gly Lys Gln Leu Ser Leu Thr 
145                 150                 155                 160 

Ser Val Phe Glu Gly Val Gly Ala His Lys Ser Gly Asn Met Ser Ala 
                165                 170                 175     

Glu Glu Leu Leu Asp Ile Glu Asn Asn Ala Cys Pro Thr Cys Gly Ser 
            180                 185                 190         

Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Leu Met Glu Met 
        195                 200                 205             

Leu Gly Val Ala Leu Pro Gly Asn Gly Thr Ile Val Ala Thr Ser Glu 
    210                 215                 220                 

Glu Arg His Lys Leu Ile Lys Glu Ala Ala Lys Gln Leu Ile Arg Met 
225                 230                 235                 240 

Val Lys Glu Asp Ile Lys Pro Arg Asp Ile Ile Thr Lys Glu Ala Ile 
                245                 250                 255     

Asp Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr 
            260                 265                 270         

Val Leu His Thr Leu Ala Ile Ala Asn Glu Ala Glu Ile Asp Tyr Asn 
        275                 280                 285             

Ile Glu Asp Ile Asn Lys Val Ala Glu Arg Val Pro Tyr Leu Ala Lys 
    290                 295                 300                 

Ile Met Pro Ala Ser Asp Ile Ser Met Asp Asp Ile Asn Lys Ala Gly 
305                 310                 315                 320 

Gly Val Ser Ala Ile Ile Asn Glu Leu Val Ser Ile Pro Gly Ala Ile 
                325                 330                 335     

His Pro Asn Arg Pro Thr Val Ala Gly Val Thr Met Gly Glu Leu Val 
            340                 345                 350         

Lys Asp His His Ile Thr Asn Asn Gln Val Ile Arg Thr Lys Glu Asn 
        355                 360                 365             

Pro Tyr Ser Ala Val Gly Gly Leu Ser Val Leu Phe Gly Asn Ile Ala 
    370                 375                 380                 

Pro Glu Gly Ser Val Ile Lys Val Gly Ala Val Asp Pro Ser Ile Gln 
385                 390                 395                 400 

Val Phe Lys Gly Gln Ala Ile Val Phe Asp Ser Gln Glu Ala Ala Gln 
                405                 410                 415     

Glu Asn Ile Asp Asn Gly Ile Val Lys Glu Gly His Val Val Val Ile 
            420                 425                 430         

Arg Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala 
        435                 440                 445             

Pro Thr Ser Ala Ile Gln Gly Arg Gly Leu Gly Thr Lys Val Ala Leu 
    450                 455                 460                 

Ile Thr Asp Gly Arg Phe Ser Gly Ala Ser Arg Gly Ile Ser Ile Gly 
465                 470                 475                 480 

His Ile Ser Pro Glu Ala Ala Glu Gly Gly Pro Ile Ala Leu Val Glu 
                485                 490                 495     

Asp Gly Asp Met Ile Glu Ile Asp Leu Pro Asn Arg Thr Ile Asn Leu 
            500                 505                 510         

Gln Val Ser Glu Glu Val Leu Ala Glu Arg Arg Ala Lys Leu Pro Val 
        515                 520                 525             

Phe Glu Pro Lys Ile Lys Arg Gly Trp Leu Ala Arg Tyr Ser Lys Leu 
    530                 535                 540                 

Val Thr Asn Ala Ser Thr Gly Gly Val Met Lys Ile 
545                 550                 555     

<210>   159
<211>   554
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   159
Met Arg Ser Asn Met Ile Lys Lys Gly Ile Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ser Leu Leu Arg Ala Ala Gly Val Lys Glu Glu Asp Met Asp Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Ile Asp Ile Ile Pro Gly His Met 
        35                  40                  45              

His Leu Asn Lys Phe Ala Glu Val Ala Lys Glu Ala Ile Ile Glu Ala 
    50                  55                  60                  

Gly Gly Ile Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Pro Ser Arg Glu Ile 
                85                  90                  95      

Ile Cys Asp Ala Ala Glu Thr Val Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Tyr Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ala Val Arg Thr Asn Val Pro Ala Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Arg Thr Lys Glu Gly Lys Ser Leu Ser Leu Val Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Ala Phe Ser Ser Gly Lys Met Thr Arg Glu 
                165                 170                 175     

Glu Leu Leu Glu Ile Glu Gln Leu Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Ser Leu Met Glu Met Leu 
        195                 200                 205             

Gly Leu Ala Leu Pro Gly Asn Gly Thr Leu Val Ala Thr Ser Thr Glu 
    210                 215                 220                 

Arg His Asn Leu Ile Lys Asp Ala Ala Lys His Leu Ile Asn Leu Ile 
225                 230                 235                 240 

Glu Lys Asp Ile Arg Pro Arg Asp Ile Val Thr Glu Glu Thr Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Thr Leu Ala Ile Ala Asn Glu Ala Glu Ile Asp Tyr Asp Leu 
        275                 280                 285             

Thr Arg Ile Asn Glu Val Ala Glu Arg Val Pro Tyr Leu Cys Lys Ile 
    290                 295                 300                 

Ser Pro Ala Ser Asp Tyr Ser Met Asp Asp Val His Lys Ala Gly Gly 
305                 310                 315                 320 

Val Ala Ala Ile Met Lys Glu Leu Ile Glu Met Gly Ala Val Lys Gly 
                325                 330                 335     

Asp Arg Ile Thr Ile Thr Gly Lys Ser Leu Tyr Glu Asn Val Ala His 
            340                 345                 350         

Ala Gln Ile Thr Asn Thr Asp Val Ile Arg Thr Lys Glu Thr Ala Tyr 
        355                 360                 365             

Ser Pro Val Gly Gly Leu Ser Ile Leu Tyr Gly Asn Leu Ala Pro Asp 
    370                 375                 380                 

Gly Ala Val Ile Lys Val Gly Ala Val Asp Pro Ser Ile Lys Thr Phe 
385                 390                 395                 400 

Thr Gly Glu Ala Ile Val Phe Asn Ser Gln Glu Glu Ala Gln Glu Gln 
                405                 410                 415     

Ile Asn Asn Gly Ala Val Lys Glu Gly Gln Val Val Val Ile Arg Tyr 
            420                 425                 430         

Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro Thr 
        435                 440                 445             

Ser Ala Ile Gln Gly Arg Gly Leu Gly Thr Lys Val Ala Leu Ile Thr 
    450                 455                 460                 

Asp Gly Arg Phe Ser Gly Ala Ser Arg Gly Ile Ser Ile Gly His Ile 
465                 470                 475                 480 

Ser Pro Glu Ala Ala Glu Gly Gly Pro Ile Ala Phe Val Glu Asn Gly 
                485                 490                 495     

Asp Met Ile Lys Ile Asp Leu Ile Glu Arg Thr Ile Glu Trp Glu Ile 
            500                 505                 510         

Ser Glu Glu Glu Leu Ala Lys Arg Arg Glu Gly Trp Thr Glu Pro Glu 
        515                 520                 525             

Pro Lys Val Lys Lys Gly Tyr Leu Ala Arg Tyr Ser Lys Leu Val Thr 
    530                 535                 540                 

Ser Ala Asn Thr Gly Gly Val Met Lys Ile 
545                 550                 

<210>   160
<211>   558
<212>   PRT
<213>   Listeria welshimeri serovar 6b str. SLCC5334

<400>   160
Met Arg Ser Asp Lys Ile Lys Lys Gly Val Glu Gln Ala Pro Ala Arg 
                5                   10                  15      

Ser Leu Leu His Ala Thr Gly Gln Ile Lys Ser Pro Gly Asp Met Asp 
            20                  25                  30          

Lys Pro Phe Ile Ala Ile Cys Asn Ser Tyr Ile Asp Ile Val Pro Gly 
        35                  40                  45              

His Val His Leu Arg Glu Leu Ala Asp Val Ala Lys Glu Ala Ile Arg 
    50                  55                  60                  

Glu Ala Gly Gly Ile Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp 
65                  70                  75                  80  

Gly Ile Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Pro Ser Arg 
                85                  90                  95      

Glu Val Ile Ala Asp Ala Ala Glu Thr Val Ile Asn Ala His Trp Phe 
            100                 105                 110         

Asp Gly Val Phe Tyr Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met 
        115                 120                 125             

Leu Leu Ala Ser Val Arg Thr Asn Val Pro Ala Ile Phe Cys Ser Gly 
    130                 135                 140                 

Gly Pro Met Lys Ala Gly Leu Ser Ala His Gly Lys Ala Leu Thr Leu 
145                 150                 155                 160 

Ser Ser Val Phe Glu Ala Val Gly Ala Phe Lys Asp Gly Ser Met Ser 
                165                 170                 175     

Gln Glu Asp Phe Leu Asp Met Glu Ala Asn Ala Cys Pro Thr Cys Gly 
            180                 185                 190         

Ser Cys Ala Gly Met Phe Thr Ala Asn Ser Met Asn Cys Leu Met Glu 
        195                 200                 205             

Ile Leu Gly Met Ala Val Pro Gly Asn Gly Thr Thr Leu Ala Val Ser 
    210                 215                 220                 

Asp Ala Arg Arg Glu Leu Ile Arg Glu Ser Ala Phe His Leu Met Asp 
225                 230                 235                 240 

Leu Val Lys Lys Asp Ile Arg Pro Arg Asp Ile Ile Thr Lys Asp Ala 
                245                 250                 255     

Ile Asp Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn 
            260                 265                 270         

Thr Val Leu His Thr Leu Ala Leu Ala Asn Glu Ala Gly Ile Glu Asp 
        275                 280                 285             

Tyr Asp Leu Glu Arg Ile Asn Asp Ile Ala Lys Arg Val Pro Tyr Leu 
    290                 295                 300                 

Ser Lys Ile Ala Pro Ser Ser Ser Tyr Ser Met His Asp Val His Glu 
305                 310                 315                 320 

Ala Gly Gly Val Ser Ala Ile Val Lys Glu Leu Val Asp Leu Gly Gly 
                325                 330                 335     

Ala Ile His Pro Asp Arg Ile Thr Val Thr Gly Lys Thr Ile Arg Glu 
            340                 345                 350         

Asn Val Ala Asp Ala Lys Ile Asn Asn Thr Asp Val Ile His Pro Lys 
        355                 360                 365             

Glu Asn Pro Tyr Ser Pro Val Gly Gly Leu Ser Met Leu Phe Gly Asn 
    370                 375                 380                 

Ile Ala Pro Lys Gly Ala Ala Ile Lys Val Gly Gly Val Asp Pro Ser 
385                 390                 395                 400 

Val Gln Val Phe Lys Gly Glu Ala Ile Cys Phe Ser Ser His Asp Glu 
                405                 410                 415     

Ala Val Glu Ala Ile Asp Asn His Thr Val Arg Glu Gly His Val Val 
            420                 425                 430         

Val Ile Arg Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met 
        435                 440                 445             

Leu Ala Pro Thr Ser Ser Ile Val Gly Arg Gly Leu Gly Lys Asp Val 
    450                 455                 460                 

Ala Leu Ile Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Ile Ala 
465                 470                 475                 480 

Val Gly His Ile Ser Pro Glu Ala Ala Ala Gly Gly Pro Ile Ala Leu 
                485                 490                 495     

Val His Asp Gly Asp Ile Ile Thr Ile Asp Leu Pro Asn Arg Thr Leu 
            500                 505                 510         

Asn Val Asp Val Ser Asp Glu Val Leu Glu Glu Arg Arg Lys Glu Leu 
        515                 520                 525             

Pro Lys Phe Lys Ala Lys Val Lys Thr Gly Tyr Leu Ala Arg Tyr Thr 
    530                 535                 540                 

Ala Leu Val Thr Ser Ala His Thr Gly Gly Ile Leu Gln Ile 
545                 550                 555             

<210>   161
<211>   557
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   161
Met Arg Ser Asp Met Ile Lys Lys Gly Val Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ala Leu Leu Tyr Ala Thr Gly Val Lys Pro Arg Asp Leu Ser Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Val Asp Ile Val Pro Gly His Val 
        35                  40                  45              

His Leu Arg Glu Phe Ala Glu Val Val Lys Asp Ala Ile Arg Gln Ala 
    50                  55                  60                  

Gly Gly Val Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Ala Ser Arg Glu Leu 
                85                  90                  95      

Ile Ala Asp Ser Ala Glu Thr Met Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Phe Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ala Val Arg Cys Asn Val Pro Ala Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Arg Ser Arg Thr Gly Arg Pro Leu Ser Leu Ser Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Gln Tyr Met Ser Gly Gln Ile Ser Glu Asp 
                165                 170                 175     

Asp Leu Leu Asp Leu Glu Arg Asn Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Ile Met Glu Met Leu 
        195                 200                 205             

Gly Ile Ala Leu Pro Gly Asn Gly Thr Leu Val Ala Thr Ser Lys Glu 
    210                 215                 220                 

Arg His Glu Leu Ile Tyr Glu Ala Ala Lys His Leu Ile Arg Met Val 
225                 230                 235                 240 

Glu Gln Asp Ile Arg Pro Arg Asp Ile Ile Thr Arg Glu Ala Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Leu Met Ala Ile Ala His Glu Ala Gly Ile Asp Tyr Ser Leu 
        275                 280                 285             

Ser Asp Ile Asn Glu Ile Ala Lys Arg Val Pro Tyr Leu Ala Lys Ile 
    290                 295                 300                 

Ser Pro Ala Ser Glu Tyr Ser Ile Gln Asp Val His Arg Ala Gly Gly 
305                 310                 315                 320 

Val Ser Ala Ile Ile Arg Glu Leu Cys Glu His Thr Asp Ala Val His 
                325                 330                 335     

Pro Asp Arg Ile Thr Val Thr Gly Lys Thr Leu Tyr Glu Gln Val Lys 
            340                 345                 350         

Asp Ala Lys Ile Leu Asp Glu Arg Val Ile Arg Pro Ala Ser Asn Pro 
        355                 360                 365             

Tyr Ser Arg Glu Gly Gly Leu Ser Ile Leu Phe Gly Asn Leu Ala Pro 
    370                 375                 380                 

Asp Gly Ala Val Leu Lys Val Gly Ala Val Asp Pro Asp Ile Gln Arg 
385                 390                 395                 400 

Phe Val Gly Arg Ala Ile Cys Phe Asn Ser Gln Asp Glu Ala Met Glu 
                405                 410                 415     

Gly Ile Asn Ser Gly Lys Val Gln Pro Gly His Val Val Val Ile Arg 
            420                 425                 430         

Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro 
        435                 440                 445             

Thr Ser Ser Ile Val Gly Arg Gly Leu Gly Arg Glu Val Ala Leu Ile 
    450                 455                 460                 

Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Ile Cys Val Gly His 
465                 470                 475                 480 

Ile Ser Pro Glu Ala Gly Val Gly Gly Pro Ile Ala Leu Val Glu Asp 
                485                 490                 495     

Gly Asp Asp Ile Glu Ile Asp Ile Pro Asn Arg Ala Ile Thr Leu Lys 
            500                 505                 510         

Val Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Arg Tyr Gln Pro Pro 
        515                 520                 525             

Ala Lys Glu Lys Leu Thr Gly Tyr Leu Ala Arg Tyr Gln Lys Leu Val 
    530                 535                 540                 

Thr Ser Ala Asn Thr Gly Ala Val Leu Thr Val Asp Ala 
545                 550                 555         

<210>   162
<211>   557
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   162
Met Arg Ser Asp Met Ile Lys Lys Gly Val Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ala Leu Leu Tyr Ala Thr Gly Val Lys Pro Arg Asp Leu Ser Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Val Asp Ile Val Pro Gly His Val 
        35                  40                  45              

His Leu Arg Glu Phe Ala Glu Val Val Lys Asp Ala Ile Arg Gln Ala 
    50                  55                  60                  

Gly Gly Val Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Ala Ser Arg Glu Leu 
                85                  90                  95      

Ile Ala Asp Ser Ala Glu Thr Met Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Phe Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ala Val Arg Cys Asn Val Pro Ala Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Arg Ser Arg Thr Gly Arg Pro Leu Ser Leu Ser Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Gln Tyr Met Ser Gly Gln Ile Ser Glu Asp 
                165                 170                 175     

Asp Leu Leu Asp Leu Glu Arg Asn Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Ile Met Glu Met Leu 
        195                 200                 205             

Gly Ile Ala Leu Pro Gly Asn Gly Thr Leu Val Ala Thr Ser Lys Glu 
    210                 215                 220                 

Arg His Glu Leu Ile Tyr Glu Ala Ala Lys His Leu Ile Arg Met Val 
225                 230                 235                 240 

Glu Gln Asp Ile Arg Pro Arg Asp Ile Ile Thr Arg Glu Ala Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Leu Met Ala Ile Ala His Glu Ala Gly Ile Asp Tyr Ser Leu 
        275                 280                 285             

Ser Asp Ile Asn Glu Ile Ala Lys Arg Val Pro Tyr Leu Ala Lys Ile 
    290                 295                 300                 

Ser Pro Ala Ser Glu Tyr Ser Ile Gln Asp Val His Arg Ala Gly Gly 
305                 310                 315                 320 

Val Ser Ala Ile Ile Arg Glu Leu Cys Glu His Thr Asp Ala Val His 
                325                 330                 335     

Pro Asp Arg Ile Thr Val Thr Gly Lys Thr Leu Tyr Glu Gln Val Lys 
            340                 345                 350         

Asp Ala Lys Ile Leu Asp Glu Arg Val Ile Arg Pro Ala Ser Asn Pro 
        355                 360                 365             

Tyr Ser Arg Glu Gly Gly Leu Ser Ile Leu Phe Gly Asn Leu Ala Pro 
    370                 375                 380                 

Asp Gly Ala Val Leu Lys Val Gly Ala Val Asp Pro Asp Ile Gln Arg 
385                 390                 395                 400 

Phe Val Gly Arg Ala Ile Cys Phe Asn Ser Gln Asp Glu Ala Met Glu 
                405                 410                 415     

Gly Ile Asn Ser Gly Lys Val Gln Pro Gly His Val Val Val Ile Arg 
            420                 425                 430         

Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro 
        435                 440                 445             

Thr Ser Ser Ile Val Gly Arg Gly Leu Gly Arg Glu Val Ala Leu Ile 
    450                 455                 460                 

Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Ile Cys Val Gly His 
465                 470                 475                 480 

Ile Ser Pro Glu Ala Gly Val Gly Gly Pro Ile Ala Leu Val Glu Asp 
                485                 490                 495     

Gly Asp Glu Ile Asp Ile Asp Ile Pro Asn Arg Ala Ile Thr Leu Lys 
            500                 505                 510         

Val Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Arg Tyr Gln Pro Pro 
        515                 520                 525             

Ala Lys Glu Lys Leu Thr Gly Tyr Leu Ala Arg Tyr Gln Lys Leu Val 
    530                 535                 540                 

Thr Ser Ala Asn Thr Gly Ala Val Leu Thr Val Asp Ala 
545                 550                 555         

<210>   163
<211>   557
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   163
Met Arg Ser Asp Met Ile Lys Lys Gly Val Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ala Leu Leu Tyr Ala Thr Gly Val Lys Pro Arg Asp Leu Ser Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Val Asp Ile Val Pro Gly His Val 
        35                  40                  45              

His Leu Arg Glu Phe Ala Glu Val Val Lys Asp Ala Ile Arg Gln Ala 
    50                  55                  60                  

Gly Gly Val Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Ala Ser Arg Glu Leu 
                85                  90                  95      

Ile Ala Asp Ser Ala Glu Thr Met Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Phe Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ala Val Arg Cys Asn Val Pro Ala Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Arg Ser Arg Thr Gly Arg Pro Leu Ser Leu Ser Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Gln Tyr Met Ser Gly Gln Ile Ser Glu Asp 
                165                 170                 175     

Asp Leu Leu Asp Leu Glu Arg Asn Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Ile Met Glu Met Leu 
        195                 200                 205             

Gly Ile Ala Leu Pro Gly Asn Gly Thr Leu Val Ala Thr Ser Lys Glu 
    210                 215                 220                 

Arg His Glu Leu Ile Tyr Glu Ala Ala Lys His Leu Ile Arg Met Val 
225                 230                 235                 240 

Glu Gln Asp Ile Arg Pro Arg Asp Ile Ile Thr Arg Glu Ala Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Leu Met Ala Ile Ala His Glu Ala Gly Ile Asp Tyr Ser Leu 
        275                 280                 285             

Ser Asp Ile Asn Glu Ile Ala Lys Arg Val Pro Tyr Leu Ala Lys Ile 
    290                 295                 300                 

Ser Pro Ala Ser Glu Tyr Ser Ile Gln Asp Val His Arg Ala Gly Gly 
305                 310                 315                 320 

Val Ser Ala Ile Ile Arg Glu Leu Cys Glu His Thr Asp Ala Val His 
                325                 330                 335     

Pro Asp Arg Ile Thr Val Thr Gly Lys Thr Leu Tyr Glu Gln Val Lys 
            340                 345                 350         

Asp Ala Lys Ile Leu Asp Glu Arg Val Ile Arg Pro Ala Ser Asn Pro 
        355                 360                 365             

Tyr Ser Arg Glu Gly Gly Leu Ser Ile Leu Phe Gly Asn Leu Ala Pro 
    370                 375                 380                 

Asp Gly Ala Val Leu Lys Val Gly Ala Val Asp Pro Asp Ile Gln Arg 
385                 390                 395                 400 

Phe Val Gly Arg Ala Ile Cys Phe Asn Ser Gln Asp Glu Ala Met Glu 
                405                 410                 415     

Gly Ile Asn Ser Gly Lys Val Gln Pro Gly His Val Val Val Ile Arg 
            420                 425                 430         

Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro 
        435                 440                 445             

Thr Ser Ser Ile Val Gly Arg Gly Leu Gly Lys Glu Val Ala Leu Ile 
    450                 455                 460                 

Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Ile Cys Val Gly His 
465                 470                 475                 480 

Ile Ser Pro Glu Ala Gly Val Gly Gly Pro Ile Ala Leu Val Glu Asp 
                485                 490                 495     

Gly Asp Glu Ile Glu Ile Asp Ile Pro Asn Arg Ala Ile Thr Leu Lys 
            500                 505                 510         

Val Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Arg Tyr Gln Pro Pro 
        515                 520                 525             

Ala Lys Glu Lys Leu Thr Gly Tyr Leu Ala Arg Tyr Gln Lys Leu Val 
    530                 535                 540                 

Thr Ser Ala Asn Thr Gly Ala Val Leu Thr Val Asp Ala 
545                 550                 555         

<210>   164
<211>   557
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   164
Met Arg Ser Asp Met Ile Lys Lys Gly Val Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ala Leu Leu Tyr Ala Thr Gly Val Lys Pro Arg Asp Leu Ser Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Val Asp Ile Val Pro Gly His Val 
        35                  40                  45              

His Leu Arg Glu Phe Ala Glu Val Val Lys Asp Ala Ile Arg Gln Ala 
    50                  55                  60                  

Gly Gly Val Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Ala Ser Arg Glu Leu 
                85                  90                  95      

Ile Ala Asp Ser Ala Glu Thr Met Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Phe Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ala Val Arg Cys Asn Val Pro Ala Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Arg Ser Arg Thr Gly Arg Pro Leu Ser Leu Ser Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Gln Tyr Met Ser Gly Gln Ile Ser Glu Asp 
                165                 170                 175     

Asp Leu Leu Asp Leu Glu Arg Asn Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Ile Met Glu Met Leu 
        195                 200                 205             

Gly Ile Ala Leu Pro Gly Asn Gly Thr Leu Val Ala Thr Ser Lys Glu 
    210                 215                 220                 

Arg His Glu Leu Ile Tyr Glu Ala Ala Lys His Leu Ile Arg Met Val 
225                 230                 235                 240 

Glu Gln Asp Ile Arg Pro Arg Asp Ile Ile Thr Arg Glu Ala Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Leu Met Ala Ile Ala His Glu Ala Gly Ile Asp Tyr Ser Leu 
        275                 280                 285             

Ser Asp Ile Asn Glu Ile Ala Lys Arg Val Pro Tyr Leu Ala Lys Ile 
    290                 295                 300                 

Ser Pro Ala Ser Glu Tyr Ser Ile Gln Asp Val His Arg Ala Gly Gly 
305                 310                 315                 320 

Val Ser Ala Ile Ile Arg Glu Leu Cys Glu His Thr Asp Ala Val His 
                325                 330                 335     

Pro Asp Arg Ile Thr Val Thr Gly Lys Thr Leu Tyr Glu Gln Val Lys 
            340                 345                 350         

Asp Ala Lys Ile Leu Asp Glu Arg Val Ile Arg Pro Ala Ser Asn Pro 
        355                 360                 365             

Tyr Ser Arg Glu Gly Gly Leu Ser Ile Leu Phe Gly Asn Leu Ala Pro 
    370                 375                 380                 

Asp Gly Ala Val Leu Lys Val Gly Ala Val Asp Pro Asp Ile Gln Arg 
385                 390                 395                 400 

Phe Val Gly Arg Ala Ile Cys Phe Asn Ser Gln Asp Glu Ala Met Glu 
                405                 410                 415     

Gly Ile Asn Ser Gly Lys Val Gln Pro Gly His Val Val Val Ile Arg 
            420                 425                 430         

Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro 
        435                 440                 445             

Thr Ser Ser Ile Val Gly Arg Gly Leu Gly Arg Glu Val Ala Leu Ile 
    450                 455                 460                 

Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Ile Cys Val Gly His 
465                 470                 475                 480 

Ile Ser Pro Glu Ala Gly Val Gly Gly Pro Ile Ala Leu Val Glu Asp 
                485                 490                 495     

Gly Asp Glu Ile Glu Ile Asp Ile Pro Asn Arg Ala Ile Thr Leu Lys 
            500                 505                 510         

Val Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Arg Tyr Gln Pro Pro 
        515                 520                 525             

Ala Lys Glu Lys Leu Thr Gly Tyr Leu Ala Arg Tyr Gln Lys Leu Val 
    530                 535                 540                 

Thr Ser Ala Asn Thr Gly Ala Val Leu Thr Val Glu Ala 
545                 550                 555         

<210>   165
<211>   557
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   165
Met Arg Ser Asp Met Ile Lys Lys Gly Val Asp Arg Ala Pro His Arg 
                5                   10                  15      

Ala Leu Leu Tyr Ala Thr Gly Val Lys Pro Arg Asp Leu Ser Lys Pro 
            20                  25                  30          

Phe Ile Gly Val Cys Asn Ser Tyr Val Asp Ile Val Pro Gly His Val 
        35                  40                  45              

His Leu Arg Glu Phe Ala Glu Val Val Lys Asp Ala Ile Arg Gln Ala 
    50                  55                  60                  

Gly Gly Val Pro Phe Glu Phe Asn Thr Ile Gly Val Asp Asp Gly Ile 
65                  70                  75                  80  

Ala Met Gly His Ile Gly Met Arg Tyr Ser Leu Ala Ser Arg Glu Leu 
                85                  90                  95      

Ile Ala Asp Ser Ala Glu Thr Met Ile Asn Ala His Trp Phe Asp Gly 
            100                 105                 110         

Val Phe Phe Ile Pro Asn Cys Asp Lys Ile Thr Pro Gly Met Leu Met 
        115                 120                 125             

Ala Ala Val Arg Cys Asn Val Pro Ala Val Phe Val Ser Gly Gly Pro 
    130                 135                 140                 

Met Glu Ala Gly Arg Ser Arg Thr Gly Arg Pro Leu Ser Leu Ser Ser 
145                 150                 155                 160 

Val Phe Glu Gly Val Gly Gln Tyr Met Ser Gly Gln Ile Ser Glu Asp 
                165                 170                 175     

Asp Leu Leu Asp Leu Glu Arg Asn Ala Cys Pro Thr Cys Gly Ser Cys 
            180                 185                 190         

Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Ile Met Glu Met Leu 
        195                 200                 205             

Gly Ile Ala Leu Pro Gly Asn Gly Thr Leu Val Ala Thr Ser Lys Glu 
    210                 215                 220                 

Arg His Glu Leu Ile Tyr Glu Ala Ala Lys His Leu Ile Arg Met Val 
225                 230                 235                 240 

Glu Gln Asp Ile Arg Pro Arg Asp Ile Ile Thr Arg Glu Ala Ile Asp 
                245                 250                 255     

Asp Ala Phe Ala Leu Asp Met Ala Met Gly Gly Ser Thr Asn Thr Val 
            260                 265                 270         

Leu His Leu Met Ala Ile Ala His Glu Ala Gly Ile Asp Tyr Ser Leu 
        275                 280                 285             

Ser Asp Ile Asn Glu Ile Ala Lys Arg Val Pro Tyr Leu Ala Lys Ile 
    290                 295                 300                 

Ser Pro Ala Ser Glu Tyr Ser Ile Gln Asp Val His Arg Ala Gly Gly 
305                 310                 315                 320 

Val Ser Ala Ile Ile Arg Glu Leu Cys Glu His Thr Asp Ala Val His 
                325                 330                 335     

Pro Asp Arg Ile Thr Val Thr Gly Lys Thr Leu Tyr Glu Gln Val Lys 
            340                 345                 350         

Asp Ala Lys Ile Leu Asp Glu Arg Val Ile Arg Pro Ala Ser Asn Pro 
        355                 360                 365             

Tyr Ser Arg Glu Gly Gly Leu Ser Ile Leu Phe Gly Asn Leu Ala Pro 
    370                 375                 380                 

Asp Gly Ala Val Leu Lys Val Gly Ala Val Asp Pro Asp Ile Gln Arg 
385                 390                 395                 400 

Phe Val Gly Arg Ala Ile Cys Phe Asn Ser Gln Asp Glu Ala Met Glu 
                405                 410                 415     

Gly Ile Asn Ser Gly Lys Val Gln Pro Gly His Val Val Val Ile Arg 
            420                 425                 430         

Tyr Glu Gly Pro Lys Gly Gly Pro Gly Met Pro Glu Met Leu Ala Pro 
        435                 440                 445             

Thr Ser Ser Ile Val Gly Arg Gly Leu Gly Arg Glu Val Ala Leu Ile 
    450                 455                 460                 

Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Ile Cys Val Gly His 
465                 470                 475                 480 

Ile Ser Pro Glu Ala Gly Val Gly Gly Pro Ile Ala Leu Val Glu Asp 
                485                 490                 495     

Gly Asp Glu Ile Glu Ile Asp Ile Pro Asn Arg Ala Ile Thr Leu Lys 
            500                 505                 510         

Val Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Arg Tyr Gln Pro Pro 
        515                 520                 525             

Ala Lys Glu Arg Leu Thr Gly Tyr Leu Ala Arg Tyr Gln Lys Leu Val 
    530                 535                 540                 

Thr Ser Ala Asn Thr Gly Ala Val Leu Thr Val Asp Ala 
545                 550                 555         

<210>   166
<211>   1674
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   166
atgagaagcg acatgatcaa aaagggcgtg gaccgggcgc cgcacagggc cctgctctat       60

gccacgggcg tcaaacccag ggatctgtcc aaaccgttta tcggcgtgtg caactcgtac      120

gtcgacatcg ttccgggcca cgttcatctc cgcgaattcg cggaagtcgt gaaagatgcc      180

atccgccagg caggtggcgt cccgttcgaa ttcaacacca tcggtgtgga cgacgggatc      240

gccatggggc acatcggcat gcggtattcg ctcgcgagcc gcgagctcat cgccgattcg      300

gccgagacga tgatcaacgc ccactggttc gacggcgtct ttttcatccc caactgtgac      360

aagatcacgc ccggcatgct catggcggcc gtgcgctgca acgtgccggc ggtcttcgtc      420

tccggcggcc cgatggaggc cgggaggtcg cgcacgggtc gtccgctttc cctcagctcg      480

gtcttcgaag gcgtgggcca gtacatgagc gggcaaatct ccgaagatga cctgctggat      540

ctggagcgga acgcgtgtcc cacgtgtggc tcgtgttctg gcatgttcac cgccaactcc      600

atgaactgca tcatggagat gctggggatt gcgctccccg gcaatggcac gctggtcgcc      660

acgtccaagg agcggcacga gctgatttat gaggccgcca aacacctcat tcgcatggtg      720

gagcaggaca ttcggccgcg cgacatcatc acccgcgaag ccattgatga cgcgttcgcg      780

ctggatatgg ccatgggcgg atcgaccaac acggttctgc acctgatggc catcgcgcat      840

gaggcgggca tcgactattc cctgagcgat atcaacgaaa ttgccaaaag agtgccgtat      900

ctcgcgaaga ttagtcccgc gtccgagtac agcatccagg acgtgcaccg cgcgggcggc      960

gtgtccgcca tcatccgcga gctgtgcgaa cacaccgacg cggttcaccc ggatcgcatc     1020

acggtgacgg gcaagacgct gtacgagcag gtcaaggacg cgaagatcct cgacgaacgc     1080

gtcatccgcc cggcttccaa cccgtacagc cgcgagggcg gtctgtccat cctgtttggc     1140

aatctcgcgc cggacggcgc ggtgctgaaa gtcggtgcgg tcgatcccga catccagcga     1200

ttcgtgggcc gcgccatctg cttcaattcg caggacgagg cgatggaggg catcaacagc     1260

ggcaaggtgc aaccgggtca cgtcgtggtc attcgctatg aagggccgaa gggcgggccg     1320

gggatgcccg agatgctggc gcccacgtcg tccatcgtgg gccggggcct cggccgcgag     1380

gtggccctta tcacggacgg ccggttttcg ggggccacgc gagggatttg cgtcggccat     1440

atctcgcccg aggccggcgt aggtgggccg attgcgctcg tcgaggatgg ggacgatatc     1500

gagatcgaca ttccgaatcg cgccatcacc ctgaaggtgt cggacgagga actggcagcg     1560

cgcagggcgc gatatcagcc gcccgcgaaa gaaaagctca cgggctacct cgctcgatat     1620

cagaagttgg tcacgtcggc gaacaccggt gctgttctga cggtggacgc atga           1674


<210>   167
<211>   1674
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   167
atgagaagcg acatgatcaa aaagggcgtg gaccgggcgc cgcacagggc cctgctctat       60

gccacgggcg tcaaacccag ggatctgtcc aaaccgttta tcggcgtgtg caactcgtac      120

gtcgacatcg ttccgggcca cgttcatctc cgcgaattcg cggaagtcgt gaaagatgcc      180

atccgccagg caggtggcgt cccgttcgaa ttcaacacca tcggtgtgga cgacgggatc      240

gccatggggc acatcggcat gcggtattcg ctcgcgagcc gcgagctcat cgccgattcg      300

gccgagacga tgatcaacgc ccactggttc gacggcgtct ttttcatccc caactgtgac      360

aagatcacgc ccggcatgct catggcggcc gtgcgctgca acgtgccggc ggtcttcgtc      420

tccggcggcc cgatggaggc cgggaggtcg cgcacgggtc gtccgctttc cctcagctcg      480

gtcttcgaag gcgtgggcca gtacatgagc gggcaaatct ccgaagatga cctgctggat      540

ctggagcgga acgcgtgtcc cacgtgtggc tcgtgttctg gcatgttcac cgccaactcc      600

atgaactgca tcatggagat gctggggatt gcgctccccg gcaatggcac gctggtcgcc      660

acgtccaagg agcggcacga gctgatttat gaggccgcca aacacctcat tcgcatggtg      720

gagcaggaca ttcggccgcg cgacatcatc acccgcgaag ccattgatga cgcgttcgcg      780

ctggatatgg ccatgggcgg atcgaccaac acggttctgc acctgatggc catcgcgcat      840

gaggcgggca tcgactattc cctgagcgat atcaacgaaa ttgccaaaag agtgccgtat      900

ctcgcgaaga ttagtcccgc gtccgagtac agcatccagg acgtgcaccg cgcgggcggc      960

gtgtccgcca tcatccgcga gctgtgcgaa cacaccgacg cggttcaccc ggatcgcatc     1020

acggtgacgg gcaagacgct gtacgagcag gtcaaggacg cgaagatcct cgacgaacgc     1080

gtcatccgcc cggcttccaa cccgtacagc cgcgagggcg gtctgtccat cctgtttggc     1140

aatctcgcgc cggacggcgc ggtgctgaaa gtcggtgcgg tcgatcccga catccagcga     1200

ttcgtgggcc gcgccatctg cttcaattcg caggacgagg cgatggaggg catcaacagc     1260

ggcaaggtgc aaccgggtca cgtcgtggtc attcgctatg aagggccgaa gggcgggccg     1320

gggatgcccg agatgctggc gcccacgtcg tccatcgtgg gccggggcct cggccgcgag     1380

gtggccctta tcacggacgg ccggttttcg ggggccacgc gagggatttg cgtcggccat     1440

atctcgcccg aggccggcgt aggtgggccg attgcgctcg tcgaggatgg ggacgagatc     1500

gatatcgaca ttccgaatcg cgccatcacc ctgaaggtgt cggacgagga actggcagcg     1560

cgcagggcgc gatatcagcc gcccgcgaaa gaaaagctca cgggctacct cgctcgatat     1620

cagaagttgg tcacgtcggc gaacaccggt gctgttctga cggtggacgc atga           1674


<210>   168
<211>   1674
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   168
atgagaagcg acatgatcaa aaagggcgtg gaccgggcgc cgcacagggc cctgctctat       60

gccacgggcg tcaaacccag ggatctgtcc aaaccgttta tcggcgtgtg caactcgtac      120

gtcgacatcg ttccgggcca cgttcatctc cgcgaattcg cggaagtcgt gaaagatgcc      180

atccgccagg caggtggcgt cccgttcgaa ttcaacacca tcggtgtgga cgacgggatc      240

gccatggggc acatcggcat gcggtattcg ctcgcgagcc gcgagctcat cgccgattcg      300

gccgagacga tgatcaacgc ccactggttc gacggcgtct ttttcatccc caactgtgac      360

aagatcacgc ccggcatgct catggcggcc gtgcgctgca acgtgccggc ggtcttcgtc      420

tccggcggcc cgatggaggc cgggaggtcg cgcacgggtc gtccgctttc cctcagctcg      480

gtcttcgaag gcgtgggcca gtacatgagc gggcaaatct ccgaagatga cctgctggat      540

ctggagcgga acgcgtgtcc cacgtgtggc tcgtgttctg gcatgttcac cgccaactcc      600

atgaactgca tcatggagat gctggggatt gcgctccccg gcaatggcac gctggtcgcc      660

acgtccaagg agcggcacga gctgatttat gaggccgcca aacacctcat tcgcatggtg      720

gagcaggaca ttcggccgcg cgacatcatc acccgcgaag ccattgatga cgcgttcgcg      780

ctggatatgg ccatgggcgg atcgaccaac acggttctgc acctgatggc catcgcgcat      840

gaggcgggca tcgactattc cctgagcgat atcaacgaaa ttgccaaaag agtgccgtat      900

ctcgcgaaga ttagtcccgc gtccgagtac agcatccagg acgtgcaccg cgcgggcggc      960

gtgtccgcca tcatccgcga gctgtgcgaa cacaccgacg cggttcaccc ggatcgcatc     1020

acggtgacgg gcaagacgct gtacgagcag gtcaaggacg cgaagatcct cgacgaacgc     1080

gtcatccgcc cggcttccaa cccgtacagc cgcgagggcg gtctgtccat cctgtttggc     1140

aatctcgcgc cggacggcgc ggtgctgaaa gtcggtgcgg tcgatcccga catccagcga     1200

ttcgtgggcc gcgccatctg cttcaattcg caggacgagg cgatggaggg catcaacagc     1260

ggcaaggtgc aaccgggtca cgtcgtggtc attcgctatg aagggccgaa gggcgggccg     1320

gggatgcccg agatgctggc gcccacgtcg tccatcgtgg gccggggcct cggcaaagag     1380

gtggccctta tcacggacgg ccggttttcg ggggccacgc gagggatttg cgtcggccat     1440

atctcgcccg aggccggcgt aggtgggccg attgcgctcg tcgaggatgg ggacgagatc     1500

gagatcgaca ttccgaatcg cgccatcacc ctgaaggtgt cggacgagga actggcagcg     1560

cgcagggcgc gatatcagcc gcccgcgaaa gaaaagctca cgggctacct cgctcgatat     1620

cagaagttgg tcacgtcggc gaacaccggt gctgttctga cggtggacgc atga           1674


<210>   169
<211>   1674
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   169
atgagaagcg acatgatcaa aaagggcgtg gaccgggcgc cgcacagggc cctgctctat       60

gccacgggcg tcaaacccag ggatctgtcc aaaccgttta tcggcgtgtg caactcgtac      120

gtcgacatcg ttccgggcca cgttcatctc cgcgaattcg cggaagtcgt gaaagatgcc      180

atccgccagg caggtggcgt cccgttcgaa ttcaacacca tcggtgtgga cgacgggatc      240

gccatggggc acatcggcat gcggtattcg ctcgcgagcc gcgagctcat cgccgattcg      300

gccgagacga tgatcaacgc ccactggttc gacggcgtct ttttcatccc caactgtgac      360

aagatcacgc ccggcatgct catggcggcc gtgcgctgca acgtgccggc ggtcttcgtc      420

tccggcggcc cgatggaggc cgggaggtcg cgcacgggtc gtccgctttc cctcagctcg      480

gtcttcgaag gcgtgggcca gtacatgagc gggcaaatct ccgaagatga cctgctggat      540

ctggagcgga acgcgtgtcc cacgtgtggc tcgtgttctg gcatgttcac cgccaactcc      600

atgaactgca tcatggagat gctggggatt gcgctccccg gcaatggcac gctggtcgcc      660

acgtccaagg agcggcacga gctgatttat gaggccgcca aacacctcat tcgcatggtg      720

gagcaggaca ttcggccgcg cgacatcatc acccgcgaag ccattgatga cgcgttcgcg      780

ctggatatgg ccatgggcgg atcgaccaac acggttctgc acctgatggc catcgcgcat      840

gaggcgggca tcgactattc cctgagcgat atcaacgaaa ttgccaaaag agtgccgtat      900

ctcgcgaaga ttagtcccgc gtccgagtac agcatccagg acgtgcaccg cgcgggcggc      960

gtgtccgcca tcatccgcga gctgtgcgaa cacaccgacg cggttcaccc ggatcgcatc     1020

acggtgacgg gcaagacgct gtacgagcag gtcaaggacg cgaagatcct cgacgaacgc     1080

gtcatccgcc cggcttccaa cccgtacagc cgcgagggcg gtctgtccat cctgtttggc     1140

aatctcgcgc cggacggcgc ggtgctgaaa gtcggtgcgg tcgatcccga catccagcga     1200

ttcgtgggcc gcgccatctg cttcaattcg caggacgagg cgatggaggg catcaacagc     1260

ggcaaggtgc aaccgggtca cgtcgtggtc attcgctatg aagggccgaa gggcgggccg     1320

gggatgcccg agatgctggc gcccacgtcg tccatcgtgg gccggggcct cggccgcgag     1380

gtggccctta tcacggacgg ccggttttcg ggggccacgc gagggatttg cgtcggccat     1440

atctcgcccg aggccggcgt aggtgggccg attgcgctcg tcgaggatgg ggacgagatc     1500

gagatcgaca ttccgaatcg cgccatcacc ctgaaggtgt cggacgagga actggcagcg     1560

cgcagggcgc gatatcagcc gcccgcgaaa gaaaagctca cgggctacct cgctcgatat     1620

cagaagttgg tcacgtcggc gaacaccggt gctgttctga cggtggaagc atga           1674


<210>   170
<211>   1674
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   170
atgagaagcg acatgatcaa aaagggcgtg gaccgggcgc cgcacagggc cctgctctat       60

gccacgggcg tcaaacccag ggatctgtcc aaaccgttta tcggcgtgtg caactcgtac      120

gtcgacatcg ttccgggcca cgttcatctc cgcgaattcg cggaagtcgt gaaagatgcc      180

atccgccagg caggtggcgt cccgttcgaa ttcaacacca tcggtgtgga cgacgggatc      240

gccatggggc acatcggcat gcggtattcg ctcgcgagcc gcgagctcat cgccgattcg      300

gccgagacga tgatcaacgc ccactggttc gacggcgtct ttttcatccc caactgtgac      360

aagatcacgc ccggcatgct catggcggcc gtgcgctgca acgtgccggc ggtcttcgtc      420

tccggcggcc cgatggaggc cgggaggtcg cgcacgggtc gtccgctttc cctcagctcg      480

gtcttcgaag gcgtgggcca gtacatgagc gggcaaatct ccgaagatga cctgctggat      540

ctggagcgga acgcgtgtcc cacgtgtggc tcgtgttctg gcatgttcac cgccaactcc      600

atgaactgca tcatggagat gctggggatt gcgctccccg gcaatggcac gctggtcgcc      660

acgtccaagg agcggcacga gctgatttat gaggccgcca aacacctcat tcgcatggtg      720

gagcaggaca ttcggccgcg cgacatcatc acccgcgaag ccattgatga cgcgttcgcg      780

ctggatatgg ccatgggcgg atcgaccaac acggttctgc acctgatggc catcgcgcat      840

gaggcgggca tcgactattc cctgagcgat atcaacgaaa ttgccaaaag agtgccgtat      900

ctcgcgaaga ttagtcccgc gtccgagtac agcatccagg acgtgcaccg cgcgggcggc      960

gtgtccgcca tcatccgcga gctgtgcgaa cacaccgacg cggttcaccc ggatcgcatc     1020

acggtgacgg gcaagacgct gtacgagcag gtcaaggacg cgaagatcct cgacgaacgc     1080

gtcatccgcc cggcttccaa cccgtacagc cgcgagggcg gtctgtccat cctgtttggc     1140

aatctcgcgc cggacggcgc ggtgctgaaa gtcggtgcgg tcgatcccga catccagcga     1200

ttcgtgggcc gcgccatctg cttcaattcg caggacgagg cgatggaggg catcaacagc     1260

ggcaaggtgc aaccgggtca cgtcgtggtc attcgctatg aagggccgaa gggcgggccg     1320

gggatgcccg agatgctggc gcccacgtcg tccatcgtgg gccggggcct cggccgcgag     1380

gtggccctta tcacggacgg ccggttttcg ggggccacgc gagggatttg cgtcggccat     1440

atctcgcccg aggccggcgt aggtgggccg attgcgctcg tcgaggatgg ggacgagatc     1500

gagatcgaca ttccgaatcg cgccatcacc ctgaaggtgt cggacgagga actggcagcg     1560

cgcagggcgc gatatcagcc gcccgcgaaa gaacgtctca cgggctacct cgctcgatat     1620

cagaagttgg tcacgtcggc gaacaccggt gctgttctga cggtggacgc atga           1674


<210>   171
<211>   586
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   171
Met Trp Arg Gly Gly Asn Ala Met Pro Gly Met Ser Lys Pro Ala Asp 
                5                   10                  15      

Asp Glu Thr Leu Thr Arg Ser Gly Glu Gly Gly Ala Met Trp Met Lys 
            20                  25                  30          

Gly Ala Asp Met Val Val Glu Ala Leu Arg Arg Glu Gln Val Glu Val 
        35                  40                  45              

Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Leu Tyr Asp Ala Leu 
    50                  55                  60                  

Tyr Gln Cys Gly Ile Arg His Val Leu Thr Arg His Glu Gln Gly Ala 
65                  70                  75                  80  

Ile His Ala Ala Glu Gly Tyr Ala Arg Val Thr Gly Lys Pro Gly Val 
                85                  90                  95      

Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val Thr Gly Leu 
            100                 105                 110         

Ala Asp Ala Met Met Asp Ser Ile Pro Leu Val Ala Ile Thr Gly Gln 
        115                 120                 125             

Val Ala Lys Thr Val Ile Gly Thr Asp Ala Phe Gln Glu Thr Ser Ile 
    130                 135                 140                 

Ile Gly Ile Ser Thr Pro Ile Thr Lys His Asn Tyr Gln Ile Arg His 
145                 150                 155                 160 

Ala Ser Glu Ile Pro Lys Val Phe Lys Glu Ala Phe His Ile Ala Asn 
                165                 170                 175     

Ser Gly Arg Lys Gly Pro Val Leu Ile Asp Ile Pro Lys Asp Val Ser 
            180                 185                 190         

Gly Glu Glu Ala Trp Phe Ala Tyr Asp Asp Pro Pro Gln Leu Pro Gly 
        195                 200                 205             

Tyr Gln Pro Thr Val Val Pro His His Met Gln Ile Arg Lys Leu Met 
    210                 215                 220                 

His Gly Leu Gln His Ala Lys Arg Pro Val Val Leu Ala Gly Ala Gly 
225                 230                 235                 240 

Val Leu His Ala Arg Ala Thr Glu Lys Leu Leu Ala Phe Val Glu Lys 
                245                 250                 255     

Tyr Gln Leu Pro Val Val Gln Thr Leu Leu Gly Leu Gly Ser Phe Pro 
            260                 265                 270         

Ala Ser His Pro Leu Cys Leu Gly Met Gly Gly Met His Gly Ser Ala 
        275                 280                 285             

Ala Ala Asn Lys Ala Leu Tyr Glu Thr Asp Phe Leu Ile Asn Leu Gly 
    290                 295                 300                 

Ala Arg Phe Asp Asp Arg Leu Thr Gly Lys Leu Glu His Phe Ala Pro 
305                 310                 315                 320 

His Ala Val Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys 
                325                 330                 335     

Asn Val Pro Thr Asp Ile Pro Val Val Gly Asp Val Gly Glu Ala Leu 
            340                 345                 350         

Ser Met Met Leu Ser Ile Asp Val Pro Ala Pro Asp Ala Glu Ala Trp 
        355                 360                 365             

Arg Glu Glu Leu Leu Arg Val Lys Arg Glu Leu Pro Phe Trp Trp Val 
    370                 375                 380                 

Gln Asp Gly Lys His Ile Lys Pro Gln Arg Leu Ile Ser Glu Ile Ala 
385                 390                 395                 400 

Arg Ile Thr Lys Gly Asp Val Val Val Thr Thr Asp Val Gly Gln His 
                405                 410                 415     

Gln Met Trp Ala Ala Gln Phe Phe Pro Leu Asn Gln Pro Asp Arg Trp 
            420                 425                 430         

Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu Pro Ala Ala 
        435                 440                 445             

Ile Gly Ala His Phe Gly Gln Pro Asp Lys Leu Val Val Ala Ile Leu 
    450                 455                 460                 

Gly Asp Ala Gly Phe Gln Met Thr Leu Gln Glu Leu Ala Val Ile Gly 
465                 470                 475                 480 

Glu His Gln Leu Pro Ile Lys Val Val Ile Val Asn Asn Ser Ala Leu 
                485                 490                 495     

Gly Met Val Arg Gln Trp Gln Glu Leu Phe His Gly Glu Arg Tyr Ser 
            500                 505                 510         

Glu Ser Leu Leu Pro Trp Gln Pro Asp Phe Val Lys Leu Gly Glu Ala 
        515                 520                 525             

Tyr Arg Ile Pro Ser Ala Arg Val Glu Arg Asp Glu Asp Leu Thr Ala 
    530                 535                 540                 

Ala Leu Glu Ala Phe Leu Ser Glu Pro Gly Pro Gly Leu Leu Glu Cys 
545                 550                 555                 560 

Val Val Asp Pro Asn Glu Asn Val Tyr Pro Met Val Ala Pro Gly Thr 
                565                 570                 575     

Gly Ile His Gln Met Val Gly Val Arg Pro 
            580                 585     

<210>   172
<211>   1761
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   172
ttgtggagag gaggaaacgc gatgcctgga atgtcaaaac cggcagatga cgagacgctg       60

acgcgctcgg gagaaggcgg agccatgtgg atgaaaggtg ccgacatggt cgtagaggcg      120

ctgcgccgcg agcaggtcga ggtcatcttc gggtatcccg gtggagcggt gctaccgctg      180

tacgacgcgc tctaccaatg tggcattcgc catgtgttga cacgccatga gcaaggcgcc      240

attcacgctg cggagggcta cgctcgcgta acgggaaagc cgggcgtcgt gatcgccaca      300

agtgggccag gtgccacgaa cctcgtcacc gggttggccg acgcgatgat ggacagcatt      360

ccgctcgtcg ccatcacggg acaggtggcg aagacggtga ttggcaccga tgcgtttcag      420

gagacgtcca tcattggcat ctcgacgccc atcacaaagc ataactatca gattcggcac      480

gcgtcggaga ttccgaaggt cttcaaagag gcgttccaca tcgccaactc gggccgtaaa      540

gggcctgtgc tgatcgatat tcccaaggac gtctcagggg aagaggcgtg gttcgcgtat      600

gacgatccgc cgcagctgcc ggggtatcag ccgactgtgg tgcctcacca catgcagatt      660

cggaagttga tgcacggctt gcaacacgcc aagcggcccg tggtgctggc aggagccggc      720

gtcctgcacg cgagggcgac cgagaagctc ctggcgttcg tcgaaaagta tcagcttccg      780

gtggtgcaga ccttgctcgg ccttggcagc tttccggcgt ctcacccgct ctgcctcggc      840

atgggcggta tgcacggaag cgcggcggcc aacaaggcgc tgtacgagac ggacttcctc      900

atcaatctcg gcgcccggtt tgacgatcgg ctgaccggca agttggagca cttcgcgccg      960

cacgccgtcg tggcgcacat cgacatcgat ccggccgaga tcggcaaaaa cgtcccgacc     1020

gacattccgg tggtgggcga cgtcggcgag gcgctctcca tgatgctcag catcgacgtc     1080

ccggcgccgg acgcggaggc gtggcgcgag gaactgctgc gggtgaaaag ggaacttccg     1140

ttttggtggg tccaggatgg gaagcacatc aagccgcagc ggctcatctc ggaaattgcg     1200

cggatcacaa agggggacgt cgtggtcaca acggacgtcg gccaacacca aatgtgggct     1260

gcgcaattct tcccgctgaa tcagccggat cggtgggtga cctccggtgg actgggcacc     1320

atgggttttg gcttaccagc ggccatcggt gcgcacttcg gacagccgga taagctcgtg     1380

gtggcgatcc tgggcgacgc ggggttccag atgacgctgc aggaactcgc cgtgattggc     1440

gagcaccagt tgcccatcaa ggtcgtgatc gtcaacaaca gcgcgctggg catggtgagg     1500

cagtggcagg agctgtttca cggcgagcgg tactcggaat cgctgcttcc gtggcagcct     1560

gacttcgtga agctgggcga ggcgtaccgc attccctcgg cgcgcgtgga gcgggacgag     1620

gatctgaccg cagcgctcga ggcgtttctc agtgaaccgg gtccaggtct cctggagtgc     1680

gtggtggatc cgaacgagaa cgtgtacccc atggtcgcgc cgggcaccgg gatccaccag     1740

atggtggggg tgaggccatg a                                               1761


<210>   173
<211>   555
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   173
Met Ser Gly Ser Leu Met Leu Ile Glu Ala Leu Lys Ala Glu Asn Val 
                5                   10                  15      

Glu Val Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Leu Tyr Asp 
            20                  25                  30          

Glu Leu Tyr Lys Ala Gly Val Phe His Val Leu Thr Arg His Glu Gln 
        35                  40                  45              

Gly Ala Ile His Ala Ala Glu Gly Tyr Ala Arg Ile Ser Gly Lys Pro 
    50                  55                  60                  

Gly Val Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Ile Val Thr 
65                  70                  75                  80  

Gly Leu Thr Asp Ala Met Met Asp Ser Leu Pro Leu Val Val Phe Thr 
                85                  90                  95      

Gly Gln Val Ala Thr Asn Val Ile Gly Ser Asp Ala Phe Gln Glu Ala 
            100                 105                 110         

Asp Val Val Gly Ile Thr Met Pro Ile Thr Lys His Asn Tyr Gln Val 
        115                 120                 125             

Arg Asp Ile Ser Glu Leu Pro Lys Ile Ile Lys Glu Ala Phe His Ile 
    130                 135                 140                 

Ala Thr Thr Gly Arg Pro Gly Pro Val Leu Ile Asp Ile Pro Lys Asp 
145                 150                 155                 160 

Val Thr Ile Ala Glu Gly Glu Phe Asp Tyr Asn Gln Asp Val His Leu 
                165                 170                 175     

Pro Gly Tyr Gln Pro Thr Thr Gln Pro Asn His Trp Gln Ile Arg Arg 
            180                 185                 190         

Leu Val Glu Ala Val Ser Gln Ser Lys Arg Pro Val Ile Leu Ala Gly 
        195                 200                 205             

Ala Gly Val Leu His Ala Asn Ala Ala Asp Glu Leu Gln Gln Tyr Ala 
    210                 215                 220                 

Glu Gln Gln Asn Ile Pro Val Ala His Thr Leu Leu Gly Leu Gly Gly 
225                 230                 235                 240 

Phe Pro Ala Asp His Pro Leu Phe Leu Gly Met Ala Gly Met His Gly 
                245                 250                 255     

Thr Tyr Ala Ala Asn Met Ala Leu Tyr Glu Cys Asp Leu Leu Ile Asn 
            260                 265                 270         

Ile Gly Ala Arg Phe Asp Asp Arg Val Thr Gly Asn Leu Lys Tyr Phe 
        275                 280                 285             

Ala Pro Lys Ala Thr Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile 
    290                 295                 300                 

Gly Lys Asn Val Pro Thr Lys Ile Pro Ile Val Ser Asp Ala Lys Ala 
305                 310                 315                 320 

Ala Leu Gln Glu Leu Ile Glu Gln Gln Gly Lys Pro Ala Asp Asn Ala 
                325                 330                 335     

Ala Trp Leu Ala Gln Leu Asn Glu Trp Lys Arg Arg Phe Pro Leu His 
            340                 345                 350         

Tyr Glu Pro Glu Ala Gly Ala Ile Lys Pro Gln Lys Leu Ile Glu Met 
        355                 360                 365             

Ile Tyr Glu Val Thr Gly Gly Glu Ala Ile Val Thr Thr Asp Val Gly 
    370                 375                 380                 

Gln His Gln Met Trp Ala Ala Gln Tyr Tyr Lys Phe Asn Arg Pro Asn 
385                 390                 395                 400 

Arg Trp Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu Pro 
                405                 410                 415     

Ala Ala Ile Gly Ala Gln Leu Ala Asp Gln Ser Ala Thr Val Val Ser 
            420                 425                 430         

Ile Val Gly Asp Gly Gly Phe Gln Met Thr Cys Gln Glu Leu Ser Val 
        435                 440                 445             

Ile Gln Glu Leu Gln Leu Pro Ile Lys Val Val Ile Val Asn Asn Gln 
    450                 455                 460                 

Ala Leu Gly Met Val Arg Gln Trp Gln Glu Leu Phe Tyr Asp Lys Arg 
465                 470                 475                 480 

Tyr Ser His Ser Leu Ile Pro Asn Gln Pro Asp Phe Val Lys Leu Ala 
                485                 490                 495     

Glu Ala Tyr Gly Met Pro Gly Leu Arg Ala Lys Thr Glu Ala Glu Ala 
            500                 505                 510         

Ala Glu Val Leu Lys Gln Ala Phe Ala Ile Asp Gly Pro Val Leu Leu 
        515                 520                 525             

Asp Phe His Val Cys Ala Asp Glu Asn Val Tyr Pro Met Val Ala Pro 
    530                 535                 540                 

Gly Lys Gly Leu His Glu Met Val Gly Val Lys 
545                 550                 555 

<210>   174
<211>   557
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   174
Met Asn Gly Ala Leu Met Leu Ile Glu Ala Leu Lys Arg Glu Lys Val 
                5                   10                  15      

Glu Val Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Ile Tyr Asp 
            20                  25                  30          

Lys Ile Tyr Asp Ser Gly Leu Phe His Val Leu Pro Arg His Glu Gln 
        35                  40                  45              

Gly Ala Ile His Ala Ala Glu Gly Tyr Ala Arg Val Ser Gly Lys Pro 
    50                  55                  60                  

Gly Val Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val Thr 
65                  70                  75                  80  

Gly Ile Ala Asp Ala Met Ile Asp Ser Leu Pro Leu Val Val Phe Thr 
                85                  90                  95      

Gly Gln Val Ala Thr Ser Val Ile Gly Ser Asp Ala Phe Gln Glu Ala 
            100                 105                 110         

Asp Val Leu Gly Ile Thr Met Pro Ile Thr Lys His Ser Tyr Gln Val 
        115                 120                 125             

Arg Asn Pro Glu Glu Leu Pro Gly Val Ile Lys Glu Ala Phe His Ile 
    130                 135                 140                 

Ala Thr Thr Gly Arg Pro Gly Pro Val Leu Ile Asp Ile Pro Lys Asp 
145                 150                 155                 160 

Val Ala Gly Ile Glu Gly Thr Phe Glu Tyr Asp Gln Pro Ile Asp Leu 
                165                 170                 175     

Pro Gly Tyr Gln Pro Lys Val Glu Pro Asn Tyr Leu Gln Ile Arg Lys 
            180                 185                 190         

Leu Val Glu Ala Val Ser Arg Ala Lys Lys Pro Val Ile Leu Ala Gly 
        195                 200                 205             

Ala Gly Val Leu His Gly Lys Ala Ser Glu Glu Leu Arg Gln Tyr Val 
    210                 215                 220                 

Glu Gln Gln Gln Ile Pro Val Ala His Thr Leu Leu Gly Leu Gly Gly 
225                 230                 235                 240 

Phe Pro Ala Lys His Pro Leu Phe Leu Gly Met Ala Gly Met His Gly 
                245                 250                 255     

Thr Tyr Ala Ala Asn Met Ala Leu His Gln Cys Asp Leu Leu Ile Ser 
            260                 265                 270         

Ile Gly Ala Arg Phe Asp Asp Arg Val Thr Gly Asn Leu Asn His Phe 
        275                 280                 285             

Ala Lys His Ala Lys Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile 
    290                 295                 300                 

Gly Lys Asn Ile His Thr His Ile Pro Val Val Gly Asp Ser Lys Leu 
305                 310                 315                 320 

Val Leu Gln Glu Leu Ile Lys Gln Asp Gly Lys Gln Gly Glu Ser Asp 
                325                 330                 335     

Glu Trp Lys Asn Gln Leu Asp Gln Trp Lys Glu Glu Tyr Pro Leu Trp 
            340                 345                 350         

Tyr Val Glu Asn Glu Ala Glu Gly Phe Lys Pro Gln Lys Leu Ile Glu 
        355                 360                 365             

Tyr Ile His Gln Phe Thr Lys Gly Glu Ala Ile Val Ala Thr Asp Val 
    370                 375                 380                 

Gly Gln His Gln Met Trp Ala Ala Gln Phe Tyr Pro Phe Glu Asn Ala 
385                 390                 395                 400 

Asp Lys Trp Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu 
                405                 410                 415     

Pro Ala Ala Ile Gly Ala Gln Leu Ala Asp Gln Glu Ala Thr Val Val 
            420                 425                 430         

Ala Ile Leu Gly Asp Gly Gly Phe Gln Met Thr Leu Gln Glu Leu Ala 
        435                 440                 445             

Val Ile Arg Glu Leu Asn Leu Pro Val Lys Val Ile Val Leu Asn Asn 
    450                 455                 460                 

His Ser Leu Gly Met Val Arg Gln Trp Gln Glu Ile Phe Tyr Glu Glu 
465                 470                 475                 480 

Arg Tyr Ser Tyr Ser Lys Phe Ser Glu Gln Pro Asp Phe Val Lys Leu 
                485                 490                 495     

Ser Glu Ala Tyr Gly Ile Lys Gly Ile Arg Ile Ser Ser Asp Glu Glu 
            500                 505                 510         

Ala Lys Glu Lys Leu Glu Glu Ala Leu Thr Ser Arg Glu Pro Val Phe 
        515                 520                 525             

Ile Asp Val Asn Val Ala Arg Asp Glu Lys Val Phe Pro Met Val Ala 
    530                 535                 540                 

Pro Gly Lys Gly Leu His Glu Met Val Gly Val Lys Pro 
545                 550                 555         

<210>   175
<211>   577
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   175
Gln Gly Gly Ser Thr Met Thr Lys Met Lys Val Glu Glu Gln Glu Lys 
                5                   10                  15      

Ala Arg Thr Lys Ala Arg Met Ser Gly Ser Leu Met Leu Ile Glu Ala 
            20                  25                  30          

Leu Lys Glu Glu Lys Val Glu Val Ile Phe Gly Tyr Pro Gly Gly Ala 
        35                  40                  45              

Val Leu Pro Leu Tyr Asp Glu Leu Tyr Lys Ala Gly Val Phe His Val 
    50                  55                  60                  

Leu Thr Arg His Glu Gln Gly Ala Ile His Ala Ala Glu Gly Tyr Ala 
65                  70                  75                  80  

Arg Ile Ser Gly Lys Pro Gly Val Val Ile Ala Thr Ser Gly Pro Gly 
                85                  90                  95      

Ala Thr Asn Ile Val Thr Gly Leu Thr Asp Ala Met Met Asp Ser Leu 
            100                 105                 110         

Pro Leu Val Val Phe Thr Gly Gln Val Ala Thr Ser Val Ile Gly Ser 
        115                 120                 125             

Asp Ala Phe Gln Glu Ala Asp Val Val Gly Ile Thr Met Pro Ile Thr 
    130                 135                 140                 

Lys His Asn Tyr Gln Val Arg Asp Ile Ser Glu Leu Pro Arg Ile Ile 
145                 150                 155                 160 

Lys Glu Ala Phe His Ile Ala Thr Thr Gly Arg Pro Gly Pro Val Leu 
                165                 170                 175     

Ile Asp Ile Pro Lys Asp Ile Thr Thr Ala Glu Gly Glu Phe Asp Tyr 
            180                 185                 190         

Asp Gln Asp Val His Leu Pro Gly Tyr Gln Pro Thr Thr Gln Pro Asn 
        195                 200                 205             

His Trp Gln Ile Arg Arg Leu Val Glu Ala Val Ser Gln Ser Lys Arg 
    210                 215                 220                 

Pro Val Ile Leu Ala Gly Ala Gly Ile Leu His Ala Asn Ala Ser Asn 
225                 230                 235                 240 

Glu Leu Arg Gln Tyr Ala Glu Gln Gln Asn Ile Pro Val Ile His Thr 
                245                 250                 255     

Leu Leu Gly Leu Gly Gly Phe Pro Ala Asp His Pro Leu Phe Leu Gly 
            260                 265                 270         

Met Ala Gly Met His Gly Thr Tyr Thr Ala Asn Met Ala Leu Cys Glu 
        275                 280                 285             

Cys Asp Leu Leu Ile Asn Ile Gly Ala Arg Phe Asp Asp Arg Val Thr 
    290                 295                 300                 

Gly Asn Leu Lys Tyr Phe Ala Pro Lys Ala Thr Val Ala His Ile Asp 
305                 310                 315                 320 

Ile Asp Pro Ala Glu Ile Gly Lys Asn Val Pro Thr Lys Ile Pro Ile 
                325                 330                 335     

Val Ser Asp Ala Lys Ala Ala Leu Gln Glu Leu Ile Ala Gln Gln Gly 
            340                 345                 350         

Lys Pro Ala Asp Thr Ala Ala Trp Leu Thr Gln Leu Asp Glu Trp Lys 
        355                 360                 365             

Arg Arg Phe Pro Leu His Tyr Glu Pro Glu Ala Gly Thr Ile Lys Pro 
    370                 375                 380                 

Gln Lys Leu Ile Glu Met Ile Tyr Glu Met Thr Asn Gly Glu Ala Ile 
385                 390                 395                 400 

Val Thr Thr Asp Val Gly Gln His Gln Met Trp Ala Ala Gln Tyr Tyr 
                405                 410                 415     

Lys Phe Asn Arg Pro His Arg Trp Val Thr Ser Gly Gly Leu Gly Thr 
            420                 425                 430         

Met Gly Phe Gly Leu Pro Ala Ala Ile Gly Ala Gln Leu Ala Asp Arg 
        435                 440                 445             

Ser Ala Thr Val Val Ser Ile Val Gly Asp Gly Gly Phe Gln Met Thr 
    450                 455                 460                 

Phe Gln Glu Leu Ser Val Ile Gln Glu Leu Arg Leu Pro Ile Lys Ile 
465                 470                 475                 480 

Val Ile Val Asn Asn Gln Ala Leu Gly Met Val Arg Gln Trp Gln Glu 
                485                 490                 495     

Leu Phe Tyr Asp Lys Arg Tyr Ser His Ser Leu Ile Pro Asn Gln Pro 
            500                 505                 510         

Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly Met Pro Gly Leu Arg Ala 
        515                 520                 525             

Lys Thr Glu Ala Glu Ala Ala Glu Val Leu Lys Gln Ala Phe Ala Met 
    530                 535                 540                 

Asp Gly Pro Val Leu Leu Asp Phe His Val Arg Ala Asp Glu Asn Val 
545                 550                 555                 560 

Tyr Pro Met Val Ala Pro Gly Lys Gly Leu His Glu Met Val Gly Val 
                565                 570                 575     

Lys 
    

<210>   176
<211>   555
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   176
Met Ser Gly Ser Met Met Leu Ile Glu Ala Leu Lys Ala Glu Gln Val 
                5                   10                  15      

Glu Val Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Leu Tyr Asp 
            20                  25                  30          

Glu Leu Tyr Lys Ala Gly Val Phe His Val Leu Thr Arg His Glu Gln 
        35                  40                  45              

Gly Ala Ile His Ala Ala Glu Gly Tyr Ala Arg Ile Ser Gly Lys Pro 
    50                  55                  60                  

Gly Phe Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Ile Val Thr 
65                  70                  75                  80  

Gly Leu Thr Asp Ala Met Met Asp Ser Leu Pro Leu Val Val Phe Thr 
                85                  90                  95      

Gly Gln Val Ala Thr Ser Val Ile Gly Ser Asp Ala Phe Gln Glu Ala 
            100                 105                 110         

Asp Val Val Gly Ile Thr Met Pro Ile Thr Lys His Asn Tyr Gln Val 
        115                 120                 125             

Arg Asp Ile Ser Glu Leu Pro Lys Ile Ile Lys Glu Ala Phe His Ile 
    130                 135                 140                 

Ala Thr Thr Gly Arg Pro Gly Pro Val Leu Ile Asp Ile Pro Lys Asp 
145                 150                 155                 160 

Ile Thr Thr Ala Glu Gly Glu Phe Asp Tyr Asp Glu Glu Val Cys Leu 
                165                 170                 175     

Pro Gly Tyr Gln Pro Thr Thr Gln Pro Asn His Trp Gln Ile Arg Arg 
            180                 185                 190         

Leu Val Glu Ala Val Ser Gln Ser Lys Arg Pro Val Ile Leu Ala Gly 
        195                 200                 205             

Ala Gly Val Leu His Ala Asp Ala Ala Asn Glu Leu Arg Gln Tyr Ala 
    210                 215                 220                 

Glu Gln Gln Asn Ile Pro Val Val His Thr Leu Leu Gly Leu Gly Gly 
225                 230                 235                 240 

Phe Pro Ala Asp His Pro Leu Phe Leu Gly Met Ala Gly Met His Gly 
                245                 250                 255     

Thr Tyr Thr Ala Asn Met Ala Leu Tyr Glu Cys Asp Leu Leu Ile Asn 
            260                 265                 270         

Ile Gly Ala Arg Phe Ala Asp Arg Val Thr Gly Asn Leu Lys Tyr Phe 
        275                 280                 285             

Ala Pro Lys Ala Thr Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile 
    290                 295                 300                 

Gly Lys Asn Val Pro Thr Lys Ile Pro Ile Val Ser Asp Ala Lys Ala 
305                 310                 315                 320 

Ala Leu Gln Glu Leu Ile Ala Gln Gln Gly Lys Pro Ala Asp Asn Ala 
                325                 330                 335     

Ala Trp Leu Glu Gln Leu Asn Glu Trp Lys Arg Arg Phe Pro Leu His 
            340                 345                 350         

Tyr Glu Pro Glu Ala Gly Thr Ile Lys Pro Gln Lys Leu Ile Glu Met 
        355                 360                 365             

Ile Tyr Glu Leu Thr Asn Gly Glu Ala Ile Val Thr Thr Asp Val Gly 
    370                 375                 380                 

Gln His Gln Met Trp Ala Ala Gln Tyr Tyr Lys Phe Asn Arg Pro Asn 
385                 390                 395                 400 

Arg Trp Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu Pro 
                405                 410                 415     

Ala Ala Ile Gly Ala Gln Leu Ala Asp Arg Ser Ala Thr Val Val Ser 
            420                 425                 430         

Ile Val Gly Asp Gly Gly Phe Gln Met Thr Leu Gln Glu Leu Ser Val 
        435                 440                 445             

Ile Arg Glu Leu Gly Leu Pro Ile Lys Ile Val Ile Val Asn Asn Gln 
    450                 455                 460                 

Ala Leu Gly Met Val Arg Gln Trp Gln Glu Leu Phe Tyr Glu Lys Arg 
465                 470                 475                 480 

Tyr Ser His Ser Leu Ile Pro Asn His Pro Asp Phe Val Lys Leu Ala 
                485                 490                 495     

Glu Pro Tyr Gly Ile Pro Gly Leu Arg Ala Lys Thr Glu Ala Glu Ser 
            500                 505                 510         

Ala Glu Val Leu Lys Gln Ala Phe Ala Met Asp Gly Pro Val Leu Leu 
        515                 520                 525             

Asp Phe His Val Arg Ala Asp Glu Asn Val Tyr Pro Met Val Ser Pro 
    530                 535                 540                 

Gly Lys Gly Leu His Glu Met Val Gly Val Lys 
545                 550                 555 

<210>   177
<211>   554
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   177
Gly Ser Glu Ile Leu Leu Lys Ala Leu Ala Ser Glu Gly Val Glu Val 
                5                   10                  15      

Ile Phe Gly Tyr Pro Gly Gly Ala Ile Leu Pro Thr Tyr Asp Glu Ile 
            20                  25                  30          

Tyr Lys Leu Gly Met Asn His Ile Leu Ala Arg His Glu Gln Gly Ala 
        35                  40                  45              

Ile His Ala Ala Glu Gly Tyr Ala Arg Ile Thr Gln Lys Pro Gly Val 
    50                  55                  60                  

Cys Ile Val Thr Ser Gly Pro Gly Ala Thr Asn Val Val Thr Gly Ile 
65                  70                  75                  80  

Ala Asp Ala Met Met Asp Ser Leu Pro Met Val Val Ile Thr Gly Gln 
                85                  90                  95      

Val Ala Thr Lys Val Ile Gly Thr Asp Ala Phe Gln Glu Ala Asp Met 
            100                 105                 110         

Leu Gly Ile Thr Met Pro Ile Thr Lys His Asn Phe Gln Ile Arg Ser 
        115                 120                 125             

Ile Glu Glu Leu Ala Gln Thr Val Lys Glu Ala Phe His Ile Ala Val 
    130                 135                 140                 

Ser Gly Arg Pro Gly Pro Val Leu Ile Asp Leu Pro Lys Asp Ile Ser 
145                 150                 155                 160 

Glu Lys Leu Gly Ile Phe Asp Tyr Glu Glu Pro Val His Leu Pro Gly 
                165                 170                 175     

Tyr Gln Pro Thr Val Lys Pro Asn Lys Gln Gln Ile Arg Lys Leu Leu 
            180                 185                 190         

Asp Lys Phe Lys Glu Ala Lys Arg Pro Val Leu Leu Val Gly Ala Gly 
        195                 200                 205             

Val Leu His Ala Gln Ala Ser Glu Glu Leu Thr Ala Phe Ala Arg Lys 
    210                 215                 220                 

Phe Gln Ile Pro Val Ala Gln Thr Leu Leu Gly Leu Gly Ala Phe Pro 
225                 230                 235                 240 

Gly Glu Glu Glu Leu His Leu Gly Met Ala Gly Met His Gly Thr Tyr 
                245                 250                 255     

Ala Ala Asn Met Ala Leu His Lys Ser Asp Phe Leu Ile Asn Ile Gly 
            260                 265                 270         

Ser Arg Phe Asp Asp Arg Leu Thr Gly Ala Leu Glu His Phe Ala Pro 
        275                 280                 285             

Glu Ala Cys Ile Ala His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys 
    290                 295                 300                 

Asn Val His Val Glu Ile Pro Val Val Gly Asp Ala Lys Glu Ala Leu 
305                 310                 315                 320 

Ala Met Leu Val Lys Gly Ser Gly Ala Ile Asp Glu His Asp Glu Trp 
                325                 330                 335     

Arg Lys Gln Val Ser Asp Trp Lys Arg Asp Tyr Pro Leu Trp Phe His 
            340                 345                 350         

Arg Asp Gly Glu Val Ile Lys Pro Gln Glu Leu Ile Gln Lys Leu Tyr 
        355                 360                 365             

Glu His Thr Lys Gly Glu Ala Ile Val Thr Thr Asp Val Gly Gln His 
    370                 375                 380                 

Gln Met Trp Thr Ala Gln His Phe Lys Phe Asn Lys Pro Asn Arg Trp 
385                 390                 395                 400 

Ile Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Phe Pro Ala Ala 
                405                 410                 415     

Ile Gly Ala Gln Ile Ala Glu Pro Glu Leu Pro Val Leu Ala Ile Thr 
            420                 425                 430         

Gly Asp Ala Gly Phe Gln Met Thr Leu Gln Glu Met Ser Ile Leu Gln 
        435                 440                 445             

Glu Leu Asp Leu Pro Val Lys Ile Val Ile Val Asn Asn Ala Ser Leu 
    450                 455                 460                 

Gly Met Val Arg Gln Trp Gln Gln Arg Phe His Gly Glu Arg Tyr Ser 
465                 470                 475                 480 

His Ser Leu Phe Pro Ile Gln Pro Asn Phe Ala Lys Leu Ala Glu Ala 
                485                 490                 495     

Tyr Asn Ile Lys Ala Val Lys Val Asp Lys Leu Ser Met Leu Asp Glu 
            500                 505                 510         

Ala Ile Ala Glu Thr Leu Ala His Pro Gly Pro Val Leu Leu Glu Val 
        515                 520                 525             

Cys Val Ala Lys Glu Glu Asn Val Tyr Pro Met Val Cys Pro Gly Thr 
    530                 535                 540                 

Gly His His Cys Met Glu Gly Val Glu Pro 
545                 550                 

<210>   178
<211>   586
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   178
Met Trp Arg Gly Gly Asn Ala Met Pro Gly Met Ser Lys Pro Ala Asp 
                5                   10                  15      

Asp Glu Thr Leu Thr Arg Ser Gly Glu Gly Gly Ala Met Trp Met Lys 
            20                  25                  30          

Gly Ala Asp Met Val Val Glu Ala Leu Arg Arg Glu Gln Val Glu Val 
        35                  40                  45              

Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Leu Tyr Asp Ala Leu 
    50                  55                  60                  

Tyr Gln Cys Gly Ile Arg His Val Leu Thr Arg His Glu Gln Gly Ala 
65                  70                  75                  80  

Ile His Ala Ala Glu Gly Tyr Ala Arg Val Thr Gly Lys Pro Gly Val 
                85                  90                  95      

Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val Thr Gly Leu 
            100                 105                 110         

Ala Asp Ala Met Met Asp Ser Ile Pro Leu Val Ala Ile Thr Gly Gln 
        115                 120                 125             

Val Ala Lys Thr Val Ile Gly Thr Asp Ala Phe Gln Glu Thr Ser Ile 
    130                 135                 140                 

Ile Gly Ile Ser Thr Pro Ile Thr Lys His Asn Tyr Gln Ile Arg His 
145                 150                 155                 160 

Ala Ser Glu Ile Pro Lys Val Phe Lys Glu Ala Phe His Ile Ala Asn 
                165                 170                 175     

Ser Gly Arg Lys Gly Pro Val Leu Ile Asp Ile Pro Lys Asp Val Ser 
            180                 185                 190         

Gly Glu Glu Ala Trp Phe Ala Tyr Asp Asp Pro Pro Gln Leu Pro Gly 
        195                 200                 205             

Tyr Gln Pro Thr Val Val Pro His His Met Gln Ile Arg Lys Leu Met 
    210                 215                 220                 

His Gly Leu Gln His Ala Lys Arg Pro Val Val Leu Ala Gly Ala Gly 
225                 230                 235                 240 

Val Leu His Ala Arg Ala Thr Glu Lys Leu Leu Ala Phe Val Glu Lys 
                245                 250                 255     

Tyr Gln Leu Pro Val Val Gln Thr Leu Leu Gly Leu Gly Ser Phe Pro 
            260                 265                 270         

Ala Ser His Pro Leu Cys Leu Gly Met Gly Gly Met His Gly Ser Ala 
        275                 280                 285             

Ala Ala Asn Lys Ala Leu Tyr Glu Thr Asp Phe Leu Ile Asn Leu Gly 
    290                 295                 300                 

Ala Arg Phe Asp Asp Arg Leu Thr Gly Lys Leu Glu His Phe Ala Pro 
305                 310                 315                 320 

His Ala Val Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys 
                325                 330                 335     

Asn Val Pro Thr Asp Ile Pro Val Val Gly Asp Val Gly Glu Ala Leu 
            340                 345                 350         

Ser Met Met Leu Ser Ile Asp Val Pro Ala Pro Asp Ala Glu Ala Trp 
        355                 360                 365             

Arg Glu Glu Leu Leu Arg Val Lys Arg Asp Leu Pro Phe Trp Trp Val 
    370                 375                 380                 

Gln Asp Gly Lys His Ile Lys Pro Gln Arg Leu Ile Ser Glu Ile Ala 
385                 390                 395                 400 

Arg Ile Thr Lys Gly Asp Val Val Val Thr Thr Asp Val Gly Gln His 
                405                 410                 415     

Gln Met Trp Ala Ala Gln Phe Phe Pro Leu Asn Gln Pro Asp Arg Trp 
            420                 425                 430         

Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu Pro Ala Ala 
        435                 440                 445             

Ile Gly Ala His Phe Gly Gln Pro Asp Lys Leu Val Val Ala Ile Leu 
    450                 455                 460                 

Gly Asp Ala Gly Phe Gln Met Thr Leu Gln Glu Leu Ala Val Ile Gly 
465                 470                 475                 480 

Glu His Gln Leu Pro Ile Lys Val Val Ile Val Asn Asn Ser Ala Leu 
                485                 490                 495     

Gly Met Val Arg Gln Trp Gln Glu Leu Phe His Gly Glu Arg Tyr Ser 
            500                 505                 510         

Glu Ser Leu Leu Pro Trp Gln Pro Asp Phe Val Lys Leu Gly Glu Ala 
        515                 520                 525             

Tyr Arg Ile Pro Ser Ala Arg Val Glu Arg Asp Glu Asp Leu Thr Ala 
    530                 535                 540                 

Ala Leu Glu Ala Phe Leu Ser Glu Pro Gly Pro Gly Leu Leu Glu Cys 
545                 550                 555                 560 

Val Val Asp Pro Asn Glu Asn Val Tyr Pro Met Val Ala Pro Gly Thr 
                565                 570                 575     

Gly Ile His Gln Met Val Gly Val Arg Pro 
            580                 585     

<210>   179
<211>   586
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   179
Met Trp Arg Gly Gly Asn Ala Met Pro Gly Met Ser Lys Pro Ala Asp 
                5                   10                  15      

Asp Glu Thr Leu Thr Arg Ser Gly Glu Gly Gly Ala Met Trp Met Lys 
            20                  25                  30          

Gly Ala Asp Met Val Val Glu Ala Leu Arg Arg Glu Gln Val Glu Val 
        35                  40                  45              

Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Leu Tyr Asp Ala Leu 
    50                  55                  60                  

Tyr Gln Cys Gly Ile Arg His Val Leu Thr Arg His Glu Gln Gly Ala 
65                  70                  75                  80  

Ile His Ala Ala Glu Gly Tyr Ala Arg Val Thr Gly Lys Pro Gly Val 
                85                  90                  95      

Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val Thr Gly Leu 
            100                 105                 110         

Ala Asp Ala Met Met Asp Ser Ile Pro Leu Val Ala Ile Thr Gly Gln 
        115                 120                 125             

Val Ala Lys Thr Val Ile Gly Thr Asp Ala Phe Gln Glu Thr Ser Ile 
    130                 135                 140                 

Ile Gly Ile Ser Thr Pro Ile Thr Lys His Asn Tyr Gln Ile Arg His 
145                 150                 155                 160 

Ala Ser Glu Ile Pro Lys Val Phe Lys Glu Ala Phe His Ile Ala Asn 
                165                 170                 175     

Ser Gly Arg Lys Gly Pro Val Leu Ile Asp Ile Pro Lys Asp Val Ser 
            180                 185                 190         

Gly Glu Glu Ala Trp Phe Ala Tyr Asp Asp Pro Pro Gln Leu Pro Gly 
        195                 200                 205             

Tyr Gln Pro Thr Val Val Pro His His Met Gln Ile Arg Lys Leu Met 
    210                 215                 220                 

His Gly Leu Gln His Ala Lys Arg Pro Val Val Leu Ala Gly Ala Gly 
225                 230                 235                 240 

Val Leu His Ala Arg Ala Thr Glu Lys Leu Leu Ala Phe Val Glu Lys 
                245                 250                 255     

Tyr Gln Leu Pro Val Val Gln Thr Leu Leu Gly Leu Gly Ser Phe Pro 
            260                 265                 270         

Ala Ser His Pro Leu Cys Leu Gly Met Gly Gly Met His Gly Ser Ala 
        275                 280                 285             

Ala Ala Asn Lys Ala Leu Tyr Glu Thr Asp Phe Leu Ile Asn Leu Gly 
    290                 295                 300                 

Ala Arg Phe Asp Asp Arg Leu Thr Gly Lys Leu Glu His Phe Ala Pro 
305                 310                 315                 320 

His Ala Val Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys 
                325                 330                 335     

Asn Val Pro Thr Asp Ile Pro Val Val Gly Asp Val Gly Asp Ala Leu 
            340                 345                 350         

Ser Met Met Leu Ser Ile Asp Val Pro Ala Pro Asp Ala Glu Ala Trp 
        355                 360                 365             

Arg Glu Glu Leu Leu Arg Val Lys Arg Glu Leu Pro Phe Trp Trp Val 
    370                 375                 380                 

Gln Asp Gly Lys His Ile Lys Pro Gln Arg Leu Ile Ser Glu Ile Ala 
385                 390                 395                 400 

Arg Ile Thr Lys Gly Asp Val Val Val Thr Thr Asp Val Gly Gln His 
                405                 410                 415     

Gln Met Trp Ala Ala Gln Phe Phe Pro Leu Asn Gln Pro Asp Arg Trp 
            420                 425                 430         

Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu Pro Ala Ala 
        435                 440                 445             

Ile Gly Ala His Phe Gly Gln Pro Asp Lys Leu Val Val Ala Ile Leu 
    450                 455                 460                 

Gly Asp Ala Gly Phe Gln Met Thr Leu Gln Glu Leu Ala Val Ile Gly 
465                 470                 475                 480 

Glu His Gln Leu Pro Ile Lys Val Val Ile Val Asn Asn Ser Ala Leu 
                485                 490                 495     

Gly Met Val Arg Gln Trp Gln Glu Leu Phe His Gly Glu Arg Tyr Ser 
            500                 505                 510         

Glu Ser Leu Leu Pro Trp Gln Pro Asp Phe Val Lys Leu Gly Glu Ala 
        515                 520                 525             

Tyr Arg Ile Pro Ser Ala Arg Val Glu Arg Asp Glu Asp Leu Thr Ala 
    530                 535                 540                 

Ala Leu Glu Ala Phe Leu Ser Glu Pro Gly Pro Gly Leu Leu Glu Cys 
545                 550                 555                 560 

Val Val Asp Pro Asn Glu Asn Val Tyr Pro Met Val Ala Pro Gly Thr 
                565                 570                 575     

Gly Ile His Gln Met Val Gly Val Arg Pro 
            580                 585     

<210>   180
<211>   586
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   180
Met Trp Arg Gly Gly Asn Ala Met Pro Gly Met Ser Lys Pro Ala Asp 
                5                   10                  15      

Asp Glu Thr Leu Thr Arg Ser Gly Glu Gly Gly Ala Met Trp Met Arg 
            20                  25                  30          

Gly Ala Asp Met Val Val Glu Ala Leu Arg Arg Glu Gln Val Glu Val 
        35                  40                  45              

Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Leu Tyr Asp Ala Leu 
    50                  55                  60                  

Tyr Gln Cys Gly Ile Arg His Val Leu Thr Arg His Glu Gln Gly Ala 
65                  70                  75                  80  

Ile His Ala Ala Glu Gly Tyr Ala Arg Val Thr Gly Lys Pro Gly Val 
                85                  90                  95      

Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val Thr Gly Leu 
            100                 105                 110         

Ala Asp Ala Met Met Asp Ser Ile Pro Leu Val Ala Ile Thr Gly Gln 
        115                 120                 125             

Val Ala Lys Thr Val Ile Gly Thr Asp Ala Phe Gln Glu Thr Ser Ile 
    130                 135                 140                 

Ile Gly Ile Ser Thr Pro Ile Thr Lys His Asn Tyr Gln Ile Arg His 
145                 150                 155                 160 

Ala Ser Glu Ile Pro Lys Val Phe Lys Glu Ala Phe His Ile Ala Asn 
                165                 170                 175     

Ser Gly Arg Lys Gly Pro Val Leu Ile Asp Ile Pro Lys Asp Val Ser 
            180                 185                 190         

Gly Glu Glu Ala Trp Phe Ala Tyr Asp Asp Pro Pro Gln Leu Pro Gly 
        195                 200                 205             

Tyr Gln Pro Thr Val Val Pro His His Met Gln Ile Arg Lys Leu Met 
    210                 215                 220                 

His Gly Leu Gln His Ala Lys Arg Pro Val Val Leu Ala Gly Ala Gly 
225                 230                 235                 240 

Val Leu His Ala Arg Ala Thr Glu Lys Leu Leu Ala Phe Val Glu Lys 
                245                 250                 255     

Tyr Gln Leu Pro Val Val Gln Thr Leu Leu Gly Leu Gly Ser Phe Pro 
            260                 265                 270         

Ala Ser His Pro Leu Cys Leu Gly Met Gly Gly Met His Gly Ser Ala 
        275                 280                 285             

Ala Ala Asn Lys Ala Leu Tyr Glu Thr Asp Phe Leu Ile Asn Leu Gly 
    290                 295                 300                 

Ala Arg Phe Asp Asp Arg Leu Thr Gly Lys Leu Glu His Phe Ala Pro 
305                 310                 315                 320 

His Ala Val Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys 
                325                 330                 335     

Asn Val Pro Thr Asp Ile Pro Val Val Gly Asp Val Gly Glu Ala Leu 
            340                 345                 350         

Ser Met Met Leu Ser Ile Asp Val Pro Ala Pro Asp Ala Glu Ala Trp 
        355                 360                 365             

Arg Glu Glu Leu Leu Arg Val Lys Arg Glu Leu Pro Phe Trp Trp Val 
    370                 375                 380                 

Gln Asp Gly Lys His Ile Lys Pro Gln Arg Leu Ile Ser Glu Ile Ala 
385                 390                 395                 400 

Arg Ile Thr Lys Gly Asp Val Val Val Thr Thr Asp Val Gly Gln His 
                405                 410                 415     

Gln Met Trp Ala Ala Gln Phe Phe Pro Leu Asn Gln Pro Asp Arg Trp 
            420                 425                 430         

Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu Pro Ala Ala 
        435                 440                 445             

Ile Gly Ala His Phe Gly Gln Pro Asp Lys Leu Val Val Ala Ile Leu 
    450                 455                 460                 

Gly Asp Ala Gly Phe Gln Met Thr Leu Gln Glu Leu Ala Val Ile Gly 
465                 470                 475                 480 

Glu His Gln Leu Pro Ile Lys Val Val Ile Val Asn Asn Ser Ala Leu 
                485                 490                 495     

Gly Met Val Arg Gln Trp Gln Glu Leu Phe His Gly Glu Arg Tyr Ser 
            500                 505                 510         

Glu Ser Leu Leu Pro Trp Gln Pro Asp Phe Val Lys Leu Gly Glu Ala 
        515                 520                 525             

Tyr Arg Ile Pro Ser Ala Arg Val Glu Arg Asp Glu Asp Leu Thr Ala 
    530                 535                 540                 

Ala Leu Glu Ala Phe Leu Ser Glu Pro Gly Pro Gly Leu Leu Glu Cys 
545                 550                 555                 560 

Val Val Asp Pro Asn Glu Asn Val Tyr Pro Met Val Ala Pro Gly Thr 
                565                 570                 575     

Gly Ile His Gln Met Val Gly Val Arg Pro 
            580                 585     

<210>   181
<211>   586
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   181
Met Trp Arg Gly Gly Asn Ala Met Pro Gly Met Ser Lys Pro Ala Asp 
                5                   10                  15      

Asp Glu Thr Leu Thr Arg Ser Gly Glu Gly Gly Ala Met Trp Met Lys 
            20                  25                  30          

Gly Ala Asp Met Val Val Glu Ala Leu Arg Arg Glu Gln Val Glu Val 
        35                  40                  45              

Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Leu Tyr Asp Ala Leu 
    50                  55                  60                  

Tyr Gln Cys Gly Ile Arg His Val Leu Thr Arg His Glu Gln Gly Ala 
65                  70                  75                  80  

Ile His Ala Ala Glu Gly Tyr Ala Arg Val Thr Gly Lys Pro Gly Val 
                85                  90                  95      

Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val Thr Gly Leu 
            100                 105                 110         

Ala Asp Ala Met Met Asp Ser Ile Pro Leu Val Ala Ile Thr Gly Gln 
        115                 120                 125             

Val Ala Lys Thr Val Ile Gly Thr Asp Ala Phe Gln Glu Thr Ser Ile 
    130                 135                 140                 

Ile Gly Ile Ser Thr Pro Ile Thr Lys His Asn Tyr Gln Ile Arg His 
145                 150                 155                 160 

Ala Ser Glu Ile Pro Lys Val Phe Lys Glu Ala Phe His Ile Ala Asn 
                165                 170                 175     

Ser Gly Arg Lys Gly Pro Val Leu Ile Asp Ile Pro Lys Asp Val Ser 
            180                 185                 190         

Gly Glu Glu Ala Trp Phe Ala Tyr Asp Asp Pro Pro Gln Leu Pro Gly 
        195                 200                 205             

Tyr Gln Pro Thr Val Val Pro His His Met Gln Ile Arg Lys Leu Met 
    210                 215                 220                 

His Gly Leu Gln His Ala Lys Arg Pro Val Val Leu Ala Gly Ala Gly 
225                 230                 235                 240 

Val Leu His Ala Arg Ala Thr Glu Lys Leu Leu Ala Phe Val Glu Lys 
                245                 250                 255     

Tyr Gln Leu Pro Val Ile Gln Thr Leu Leu Gly Leu Gly Ser Phe Pro 
            260                 265                 270         

Ala Ser His Pro Leu Cys Leu Gly Met Gly Gly Met His Gly Ser Ala 
        275                 280                 285             

Ala Ala Asn Lys Ala Leu Tyr Glu Thr Asp Phe Leu Ile Asn Leu Gly 
    290                 295                 300                 

Ala Arg Phe Asp Asp Arg Leu Thr Gly Lys Leu Glu His Phe Ala Pro 
305                 310                 315                 320 

His Ala Val Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys 
                325                 330                 335     

Asn Val Pro Thr Asp Ile Pro Val Val Gly Asp Val Gly Glu Ala Leu 
            340                 345                 350         

Ser Met Met Leu Ser Ile Asp Val Pro Ala Pro Asp Ala Glu Ala Trp 
        355                 360                 365             

Arg Glu Glu Leu Leu Arg Val Lys Arg Glu Leu Pro Phe Trp Trp Val 
    370                 375                 380                 

Gln Asp Gly Lys His Ile Lys Pro Gln Arg Leu Ile Ser Glu Ile Ala 
385                 390                 395                 400 

Arg Ile Thr Lys Gly Asp Val Val Val Thr Thr Asp Val Gly Gln His 
                405                 410                 415     

Gln Met Trp Ala Ala Gln Phe Phe Pro Leu Asn Gln Pro Asp Arg Trp 
            420                 425                 430         

Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu Pro Ala Ala 
        435                 440                 445             

Ile Gly Ala His Phe Gly Gln Pro Asp Lys Leu Val Val Ala Ile Leu 
    450                 455                 460                 

Gly Asp Ala Gly Phe Gln Met Thr Leu Gln Glu Leu Ala Val Ile Gly 
465                 470                 475                 480 

Glu His Gln Leu Pro Ile Lys Val Val Ile Val Asn Asn Ser Ala Leu 
                485                 490                 495     

Gly Met Val Arg Gln Trp Gln Glu Leu Phe His Gly Glu Arg Tyr Ser 
            500                 505                 510         

Glu Ser Leu Leu Pro Trp Gln Pro Asp Phe Val Lys Leu Gly Glu Ala 
        515                 520                 525             

Tyr Arg Ile Pro Ser Ala Arg Val Glu Arg Asp Glu Asp Leu Thr Ala 
    530                 535                 540                 

Ala Leu Glu Ala Phe Leu Ser Glu Pro Gly Pro Gly Leu Leu Glu Cys 
545                 550                 555                 560 

Val Val Asp Pro Asn Glu Asn Val Tyr Pro Met Val Ala Pro Gly Thr 
                565                 570                 575     

Gly Ile His Gln Met Val Gly Val Arg Pro 
            580                 585     

<210>   182
<211>   586
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   182
Met Trp Arg Gly Gly Asn Ala Met Pro Gly Met Ser Lys Pro Ala Asp 
                5                   10                  15      

Asp Glu Thr Leu Thr Arg Ser Gly Asp Gly Gly Ala Met Trp Met Lys 
            20                  25                  30          

Gly Ala Asp Met Val Val Glu Ala Leu Arg Arg Glu Gln Val Glu Val 
        35                  40                  45              

Ile Phe Gly Tyr Pro Gly Gly Ala Val Leu Pro Leu Tyr Asp Ala Leu 
    50                  55                  60                  

Tyr Gln Cys Gly Ile Arg His Val Leu Thr Arg His Glu Gln Gly Ala 
65                  70                  75                  80  

Ile His Ala Ala Glu Gly Tyr Ala Arg Val Thr Gly Lys Pro Gly Val 
                85                  90                  95      

Val Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val Thr Gly Leu 
            100                 105                 110         

Ala Asp Ala Met Met Asp Ser Ile Pro Leu Val Ala Ile Thr Gly Gln 
        115                 120                 125             

Val Ala Lys Thr Val Ile Gly Thr Asp Ala Phe Gln Glu Thr Ser Ile 
    130                 135                 140                 

Ile Gly Ile Ser Thr Pro Ile Thr Lys His Asn Tyr Gln Ile Arg His 
145                 150                 155                 160 

Ala Ser Glu Ile Pro Lys Val Phe Lys Glu Ala Phe His Ile Ala Asn 
                165                 170                 175     

Ser Gly Arg Lys Gly Pro Val Leu Ile Asp Ile Pro Lys Asp Val Ser 
            180                 185                 190         

Gly Glu Glu Ala Trp Phe Ala Tyr Asp Asp Pro Pro Gln Leu Pro Gly 
        195                 200                 205             

Tyr Gln Pro Thr Val Val Pro His His Met Gln Ile Arg Lys Leu Met 
    210                 215                 220                 

His Gly Leu Gln His Ala Lys Arg Pro Val Val Leu Ala Gly Ala Gly 
225                 230                 235                 240 

Val Leu His Ala Arg Ala Thr Glu Lys Leu Leu Ala Phe Val Glu Lys 
                245                 250                 255     

Tyr Gln Leu Pro Val Val Gln Thr Leu Leu Gly Leu Gly Ser Phe Pro 
            260                 265                 270         

Ala Ser His Pro Leu Cys Leu Gly Met Gly Gly Met His Gly Ser Ala 
        275                 280                 285             

Ala Ala Asn Lys Ala Leu Tyr Glu Thr Asp Phe Leu Ile Asn Leu Gly 
    290                 295                 300                 

Ala Arg Phe Asp Asp Arg Leu Thr Gly Lys Leu Glu His Phe Ala Pro 
305                 310                 315                 320 

His Ala Val Val Ala His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys 
                325                 330                 335     

Asn Val Pro Thr Asp Ile Pro Val Val Gly Asp Val Gly Glu Ala Leu 
            340                 345                 350         

Ser Met Met Leu Ser Ile Asp Val Pro Ala Pro Asp Ala Glu Ala Trp 
        355                 360                 365             

Arg Glu Glu Leu Leu Arg Val Lys Arg Glu Leu Pro Phe Trp Trp Val 
    370                 375                 380                 

Gln Asp Gly Lys His Ile Lys Pro Gln Arg Leu Ile Ser Glu Ile Ala 
385                 390                 395                 400 

Arg Ile Thr Lys Gly Asp Val Val Val Thr Thr Asp Val Gly Gln His 
                405                 410                 415     

Gln Met Trp Ala Ala Gln Phe Phe Pro Leu Asn Gln Pro Asp Arg Trp 
            420                 425                 430         

Val Thr Ser Gly Gly Leu Gly Thr Met Gly Phe Gly Leu Pro Ala Ala 
        435                 440                 445             

Ile Gly Ala His Phe Gly Gln Pro Asp Lys Leu Val Val Ala Ile Leu 
    450                 455                 460                 

Gly Asp Ala Gly Phe Gln Met Thr Leu Gln Glu Leu Ala Val Ile Gly 
465                 470                 475                 480 

Glu His Gln Leu Pro Ile Lys Val Val Ile Val Asn Asn Ser Ala Leu 
                485                 490                 495     

Gly Met Val Arg Gln Trp Gln Glu Leu Phe His Gly Glu Arg Tyr Ser 
            500                 505                 510         

Glu Ser Leu Leu Pro Trp Gln Pro Asp Phe Val Lys Leu Gly Glu Ala 
        515                 520                 525             

Tyr Arg Ile Pro Ser Ala Arg Val Glu Arg Asp Glu Asp Leu Thr Ala 
    530                 535                 540                 

Ala Leu Glu Ala Phe Leu Ser Glu Pro Gly Pro Gly Leu Leu Glu Cys 
545                 550                 555                 560 

Val Val Asp Pro Asn Glu Asn Val Tyr Pro Met Val Ala Pro Gly Thr 
                565                 570                 575     

Gly Ile His Gln Met Val Gly Val Arg Pro 
            580                 585     

<210>   183
<211>   1761
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   183
ttgtggagag gaggaaacgc gatgcctgga atgtcaaaac cggcagatga cgagacgctg       60

acgcgctcgg gagaaggcgg agccatgtgg atgaaaggtg ccgacatggt cgtagaggcg      120

ctgcgccgcg agcaggtcga ggtcatcttc gggtatcccg gtggagcggt gctaccgctg      180

tacgacgcgc tctaccaatg tggcattcgc catgtgttga cacgccatga gcaaggcgcc      240

attcacgctg cggagggcta cgctcgcgta acgggaaagc cgggcgtcgt gatcgccaca      300

agtgggccag gtgccacgaa cctcgtcacc gggttggccg acgcgatgat ggacagcatt      360

ccgctcgtcg ccatcacggg acaggtggcg aagacggtga ttggcaccga tgcgtttcag      420

gagacgtcca tcattggcat ctcgacgccc atcacaaagc ataactatca gattcggcac      480

gcgtcggaga ttccgaaggt cttcaaagag gcgttccaca tcgccaactc gggccgtaaa      540

gggcctgtgc tgatcgatat tcccaaggac gtctcagggg aagaggcgtg gttcgcgtat      600

gacgatccgc cgcagctgcc ggggtatcag ccgactgtgg tgcctcacca catgcagatt      660

cggaagttga tgcacggctt gcaacacgcc aagcggcccg tggtgctggc aggagccggc      720

gtcctgcacg cgagggcgac cgagaagctc ctggcgttcg tcgaaaagta tcagcttccg      780

gtggtgcaga ccttgctcgg ccttggcagc tttccggcgt ctcacccgct ctgcctcggc      840

atgggcggta tgcacggaag cgcggcggcc aacaaggcgc tgtacgagac ggacttcctc      900

atcaatctcg gcgcccggtt tgacgatcgg ctgaccggca agttggagca cttcgcgccg      960

cacgccgtcg tggcgcacat cgacatcgat ccggccgaga tcggcaaaaa cgtcccgacc     1020

gacattccgg tggtgggcga cgtcggcgag gcgctctcca tgatgctcag catcgacgtc     1080

ccggcgccgg acgcggaggc gtggcgcgag gaactgctgc gggtgaaaag ggatcttccg     1140

ttttggtggg tccaggatgg gaagcacatc aagccgcagc ggctcatctc ggaaattgcg     1200

cggatcacaa agggggacgt cgtggtcaca acggacgtcg gccaacacca aatgtgggct     1260

gcgcaattct tcccgctgaa tcagccggat cggtgggtga cctccggtgg actgggcacc     1320

atgggttttg gcttaccagc ggccatcggt gcgcacttcg gacagccgga taagctcgtg     1380

gtggcgatcc tgggcgacgc ggggttccag atgacgctgc aggaactcgc cgtgattggc     1440

gagcaccagt tgcccatcaa ggtcgtgatc gtcaacaaca gcgcgctggg catggtgagg     1500

cagtggcagg agctgtttca cggcgagcgg tactcggaat cgctgcttcc gtggcagcct     1560

gacttcgtga agctgggcga ggcgtaccgc attccctcgg cgcgcgtgga gcgggacgag     1620

gatctgaccg cagcgctcga ggcgtttctc agtgaaccgg gtccaggtct cctggagtgc     1680

gtggtggatc cgaacgagaa cgtgtacccc atggtcgcgc cgggcaccgg gatccaccag     1740

atggtggggg tgaggccatg a                                               1761


<210>   184
<211>   1761
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   184
ttgtggagag gaggaaacgc gatgcctgga atgtcaaaac cggcagatga cgagacgctg       60

acgcgctcgg gagaaggcgg agccatgtgg atgaaaggtg ccgacatggt cgtagaggcg      120

ctgcgccgcg agcaggtcga ggtcatcttc gggtatcccg gtggagcggt gctaccgctg      180

tacgacgcgc tctaccaatg tggcattcgc catgtgttga cacgccatga gcaaggcgcc      240

attcacgctg cggagggcta cgctcgcgta acgggaaagc cgggcgtcgt gatcgccaca      300

agtgggccag gtgccacgaa cctcgtcacc gggttggccg acgcgatgat ggacagcatt      360

ccgctcgtcg ccatcacggg acaggtggcg aagacggtga ttggcaccga tgcgtttcag      420

gagacgtcca tcattggcat ctcgacgccc atcacaaagc ataactatca gattcggcac      480

gcgtcggaga ttccgaaggt cttcaaagag gcgttccaca tcgccaactc gggccgtaaa      540

gggcctgtgc tgatcgatat tcccaaggac gtctcagggg aagaggcgtg gttcgcgtat      600

gacgatccgc cgcagctgcc ggggtatcag ccgactgtgg tgcctcacca catgcagatt      660

cggaagttga tgcacggctt gcaacacgcc aagcggcccg tggtgctggc aggagccggc      720

gtcctgcacg cgagggcgac cgagaagctc ctggcgttcg tcgaaaagta tcagcttccg      780

gtggtgcaga ccttgctcgg ccttggcagc tttccggcgt ctcacccgct ctgcctcggc      840

atgggcggta tgcacggaag cgcggcggcc aacaaggcgc tgtacgagac ggacttcctc      900

atcaatctcg gcgcccggtt tgacgatcgg ctgaccggca agttggagca cttcgcgccg      960

cacgccgtcg tggcgcacat cgacatcgat ccggccgaga tcggcaaaaa cgtcccgacc     1020

gacattccgg tggtgggcga cgtcggcgat gcgctctcca tgatgctcag catcgacgtc     1080

ccggcgccgg acgcggaggc gtggcgcgag gaactgctgc gggtgaaaag ggaacttccg     1140

ttttggtggg tccaggatgg gaagcacatc aagccgcagc ggctcatctc ggaaattgcg     1200

cggatcacaa agggggacgt cgtggtcaca acggacgtcg gccaacacca aatgtgggct     1260

gcgcaattct tcccgctgaa tcagccggat cggtgggtga cctccggtgg actgggcacc     1320

atgggttttg gcttaccagc ggccatcggt gcgcacttcg gacagccgga taagctcgtg     1380

gtggcgatcc tgggcgacgc ggggttccag atgacgctgc aggaactcgc cgtgattggc     1440

gagcaccagt tgcccatcaa ggtcgtgatc gtcaacaaca gcgcgctggg catggtgagg     1500

cagtggcagg agctgtttca cggcgagcgg tactcggaat cgctgcttcc gtggcagcct     1560

gacttcgtga agctgggcga ggcgtaccgc attccctcgg cgcgcgtgga gcgggacgag     1620

gatctgaccg cagcgctcga ggcgtttctc agtgaaccgg gtccaggtct cctggagtgc     1680

gtggtggatc cgaacgagaa cgtgtacccc atggtcgcgc cgggcaccgg gatccaccag     1740

atggtggggg tgaggccatg a                                               1761


<210>   185
<211>   1761
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   185
ttgtggagag gaggaaacgc gatgcctgga atgtcaaaac cggcagatga cgagacgctg       60

acgcgctcgg gagaaggcgg agccatgtgg atgcgtggtg ccgacatggt cgtagaggcg      120

ctgcgccgcg agcaggtcga ggtcatcttc gggtatcccg gtggagcggt gctaccgctg      180

tacgacgcgc tctaccaatg tggcattcgc catgtgttga cacgccatga gcaaggcgcc      240

attcacgctg cggagggcta cgctcgcgta acgggaaagc cgggcgtcgt gatcgccaca      300

agtgggccag gtgccacgaa cctcgtcacc gggttggccg acgcgatgat ggacagcatt      360

ccgctcgtcg ccatcacggg acaggtggcg aagacggtga ttggcaccga tgcgtttcag      420

gagacgtcca tcattggcat ctcgacgccc atcacaaagc ataactatca gattcggcac      480

gcgtcggaga ttccgaaggt cttcaaagag gcgttccaca tcgccaactc gggccgtaaa      540

gggcctgtgc tgatcgatat tcccaaggac gtctcagggg aagaggcgtg gttcgcgtat      600

gacgatccgc cgcagctgcc ggggtatcag ccgactgtgg tgcctcacca catgcagatt      660

cggaagttga tgcacggctt gcaacacgcc aagcggcccg tggtgctggc aggagccggc      720

gtcctgcacg cgagggcgac cgagaagctc ctggcgttcg tcgaaaagta tcagcttccg      780

gtggtgcaga ccttgctcgg ccttggcagc tttccggcgt ctcacccgct ctgcctcggc      840

atgggcggta tgcacggaag cgcggcggcc aacaaggcgc tgtacgagac ggacttcctc      900

atcaatctcg gcgcccggtt tgacgatcgg ctgaccggca agttggagca cttcgcgccg      960

cacgccgtcg tggcgcacat cgacatcgat ccggccgaga tcggcaaaaa cgtcccgacc     1020

gacattccgg tggtgggcga cgtcggcgag gcgctctcca tgatgctcag catcgacgtc     1080

ccggcgccgg acgcggaggc gtggcgcgag gaactgctgc gggtgaaaag ggaacttccg     1140

ttttggtggg tccaggatgg gaagcacatc aagccgcagc ggctcatctc ggaaattgcg     1200

cggatcacaa agggggacgt cgtggtcaca acggacgtcg gccaacacca aatgtgggct     1260

gcgcaattct tcccgctgaa tcagccggat cggtgggtga cctccggtgg actgggcacc     1320

atgggttttg gcttaccagc ggccatcggt gcgcacttcg gacagccgga taagctcgtg     1380

gtggcgatcc tgggcgacgc ggggttccag atgacgctgc aggaactcgc cgtgattggc     1440

gagcaccagt tgcccatcaa ggtcgtgatc gtcaacaaca gcgcgctggg catggtgagg     1500

cagtggcagg agctgtttca cggcgagcgg tactcggaat cgctgcttcc gtggcagcct     1560

gacttcgtga agctgggcga ggcgtaccgc attccctcgg cgcgcgtgga gcgggacgag     1620

gatctgaccg cagcgctcga ggcgtttctc agtgaaccgg gtccaggtct cctggagtgc     1680

gtggtggatc cgaacgagaa cgtgtacccc atggtcgcgc cgggcaccgg gatccaccag     1740

atggtggggg tgaggccatg a                                               1761


<210>   186
<211>   1761
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   186
ttgtggagag gaggaaacgc gatgcctgga atgtcaaaac cggcagatga cgagacgctg       60

acgcgctcgg gagaaggcgg agccatgtgg atgaaaggtg ccgacatggt cgtagaggcg      120

ctgcgccgcg agcaggtcga ggtcatcttc gggtatcccg gtggagcggt gctaccgctg      180

tacgacgcgc tctaccaatg tggcattcgc catgtgttga cacgccatga gcaaggcgcc      240

attcacgctg cggagggcta cgctcgcgta acgggaaagc cgggcgtcgt gatcgccaca      300

agtgggccag gtgccacgaa cctcgtcacc gggttggccg acgcgatgat ggacagcatt      360

ccgctcgtcg ccatcacggg acaggtggcg aagacggtga ttggcaccga tgcgtttcag      420

gagacgtcca tcattggcat ctcgacgccc atcacaaagc ataactatca gattcggcac      480

gcgtcggaga ttccgaaggt cttcaaagag gcgttccaca tcgccaactc gggccgtaaa      540

gggcctgtgc tgatcgatat tcccaaggac gtctcagggg aagaggcgtg gttcgcgtat      600

gacgatccgc cgcagctgcc ggggtatcag ccgactgtgg tgcctcacca catgcagatt      660

cggaagttga tgcacggctt gcaacacgcc aagcggcccg tggtgctggc aggagccggc      720

gtcctgcacg cgagggcgac cgagaagctc ctggcgttcg tcgaaaagta tcagcttccg      780

gtgattcaga ccttgctcgg ccttggcagc tttccggcgt ctcacccgct ctgcctcggc      840

atgggcggta tgcacggaag cgcggcggcc aacaaggcgc tgtacgagac ggacttcctc      900

atcaatctcg gcgcccggtt tgacgatcgg ctgaccggca agttggagca cttcgcgccg      960

cacgccgtcg tggcgcacat cgacatcgat ccggccgaga tcggcaaaaa cgtcccgacc     1020

gacattccgg tggtgggcga cgtcggcgag gcgctctcca tgatgctcag catcgacgtc     1080

ccggcgccgg acgcggaggc gtggcgcgag gaactgctgc gggtgaaaag ggaacttccg     1140

ttttggtggg tccaggatgg gaagcacatc aagccgcagc ggctcatctc ggaaattgcg     1200

cggatcacaa agggggacgt cgtggtcaca acggacgtcg gccaacacca aatgtgggct     1260

gcgcaattct tcccgctgaa tcagccggat cggtgggtga cctccggtgg actgggcacc     1320

atgggttttg gcttaccagc ggccatcggt gcgcacttcg gacagccgga taagctcgtg     1380

gtggcgatcc tgggcgacgc ggggttccag atgacgctgc aggaactcgc cgtgattggc     1440

gagcaccagt tgcccatcaa ggtcgtgatc gtcaacaaca gcgcgctggg catggtgagg     1500

cagtggcagg agctgtttca cggcgagcgg tactcggaat cgctgcttcc gtggcagcct     1560

gacttcgtga agctgggcga ggcgtaccgc attccctcgg cgcgcgtgga gcgggacgag     1620

gatctgaccg cagcgctcga ggcgtttctc agtgaaccgg gtccaggtct cctggagtgc     1680

gtggtggatc cgaacgagaa cgtgtacccc atggtcgcgc cgggcaccgg gatccaccag     1740

atggtggggg tgaggccatg a                                               1761


<210>   187
<211>   1761
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   187
ttgtggagag gaggaaacgc gatgcctgga atgtcaaaac cggcagatga cgagacgctg       60

acgcgctcgg gagatggcgg agccatgtgg atgaaaggtg ccgacatggt cgtagaggcg      120

ctgcgccgcg agcaggtcga ggtcatcttc gggtatcccg gtggagcggt gctaccgctg      180

tacgacgcgc tctaccaatg tggcattcgc catgtgttga cacgccatga gcaaggcgcc      240

attcacgctg cggagggcta cgctcgcgta acgggaaagc cgggcgtcgt gatcgccaca      300

agtgggccag gtgccacgaa cctcgtcacc gggttggccg acgcgatgat ggacagcatt      360

ccgctcgtcg ccatcacggg acaggtggcg aagacggtga ttggcaccga tgcgtttcag      420

gagacgtcca tcattggcat ctcgacgccc atcacaaagc ataactatca gattcggcac      480

gcgtcggaga ttccgaaggt cttcaaagag gcgttccaca tcgccaactc gggccgtaaa      540

gggcctgtgc tgatcgatat tcccaaggac gtctcagggg aagaggcgtg gttcgcgtat      600

gacgatccgc cgcagctgcc ggggtatcag ccgactgtgg tgcctcacca catgcagatt      660

cggaagttga tgcacggctt gcaacacgcc aagcggcccg tggtgctggc aggagccggc      720

gtcctgcacg cgagggcgac cgagaagctc ctggcgttcg tcgaaaagta tcagcttccg      780

gtggtgcaga ccttgctcgg ccttggcagc tttccggcgt ctcacccgct ctgcctcggc      840

atgggcggta tgcacggaag cgcggcggcc aacaaggcgc tgtacgagac ggacttcctc      900

atcaatctcg gcgcccggtt tgacgatcgg ctgaccggca agttggagca cttcgcgccg      960

cacgccgtcg tggcgcacat cgacatcgat ccggccgaga tcggcaaaaa cgtcccgacc     1020

gacattccgg tggtgggcga cgtcggcgag gcgctctcca tgatgctcag catcgacgtc     1080

ccggcgccgg acgcggaggc gtggcgcgag gaactgctgc gggtgaaaag ggaacttccg     1140

ttttggtggg tccaggatgg gaagcacatc aagccgcagc ggctcatctc ggaaattgcg     1200

cggatcacaa agggggacgt cgtggtcaca acggacgtcg gccaacacca aatgtgggct     1260

gcgcaattct tcccgctgaa tcagccggat cggtgggtga cctccggtgg actgggcacc     1320

atgggttttg gcttaccagc ggccatcggt gcgcacttcg gacagccgga taagctcgtg     1380

gtggcgatcc tgggcgacgc ggggttccag atgacgctgc aggaactcgc cgtgattggc     1440

gagcaccagt tgcccatcaa ggtcgtgatc gtcaacaaca gcgcgctggg catggtgagg     1500

cagtggcagg agctgtttca cggcgagcgg tactcggaat cgctgcttcc gtggcagcct     1560

gacttcgtga agctgggcga ggcgtaccgc attccctcgg cgcgcgtgga gcgggacgag     1620

gatctgaccg cagcgctcga ggcgtttctc agtgaaccgg gtccaggtct cctggagtgc     1680

gtggtggatc cgaacgagaa cgtgtacccc atggtcgcgc cgggcaccgg gatccaccag     1740

atggtggggg tgaggccatg a                                               1761


<210>   188
<211>   319
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   188
Met Asn Val Ala Phe Val Phe Pro Gly Gln Gly Ala Gln Tyr Val Gly 
                5                   10                  15      

Met Gly Arg Ala Ile Phe Asp Glu Tyr Pro Val Ala Arg Ala Leu Leu 
            20                  25                  30          

Glu Glu Ala Asp Glu Ala Leu Gly Met Lys Leu Ser Asp Ile Ile Phe 
        35                  40                  45              

Glu Gly Pro Glu Asp Thr Leu Arg Leu Thr Tyr Tyr Thr Gln Pro Ala 
    50                  55                  60                  

Leu Leu Thr Val Ser Val Ala Val Trp Arg Ala Leu Val Asp Arg Val 
65                  70                  75                  80  

Asp Ile Gln Pro Leu Ala Val Ala Gly His Ser Leu Gly Glu Tyr Ser 
                85                  90                  95      

Ala Leu Val Ala Ala Lys Ser Ile Ser Phe Ala Asp Ala Val Lys Leu 
            100                 105                 110         

Val Tyr Gln Arg Gly Lys Leu Met Asp Glu Ala Tyr Pro Ala Gly Gln 
        115                 120                 125             

Gly Thr Met Ala Ala Val Leu Gly Leu Asp Glu Glu Pro Leu Arg Glu 
    130                 135                 140                 

Val Cys Lys Arg Ala Ser Glu Glu Thr Gly Glu Ile Val Glu Leu Ala 
145                 150                 155                 160 

Asn Val Asn Cys Pro Gly Gln Ile Val Ile Ser Gly Ala Lys Ala Ala 
                165                 170                 175     

Val Glu Arg Ala Ser Leu Leu Ala Lys Glu Ala Gly Ala Arg Arg Val 
            180                 185                 190         

Met Pro Leu Asn Val Ser Gly Pro Phe His Ser Ser Leu Met Gln Pro 
        195                 200                 205             

Ala Ala Asp Arg Leu Gly Ala Leu Leu Asp Glu Ile Glu Phe Ala Asp 
    210                 215                 220                 

Ala Glu Thr Pro Val Val Ala Asn Val Asp Gly His Pro Arg Arg Met 
225                 230                 235                 240 

Ala Ser Asp Leu Arg Asp Ala Leu Lys Lys Gln Leu Val Met Pro Val 
                245                 250                 255     

Arg Phe Val Asp Cys Val Leu Ser Met Lys Arg Leu Gly Val Asp Cys 
            260                 265                 270         

Val Val Glu Leu Gly Pro Gly Thr Val Leu Ser Gly Leu Val Arg Lys 
        275                 280                 285             

Ile Asp Lys Ser Leu Glu Thr Ala His Ala Glu Asp Pro Ala Thr Leu 
    290                 295                 300                 

Asp Glu Val Cys Ala Leu Leu Thr Arg Gly Gly Glu Ser Gly Glu 
305                 310                 315                 

<210>   189
<211>   960
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   189
atgaacgtcg cattcgtgtt tccaggacaa ggcgcccagt acgtcggcat ggggcgagcc       60

atctttgacg agtatcccgt ggcgcgcgcg cttctcgagg aagccgacga ggcgctcggc      120

atgaaattgt cggacatcat cttcgagggt cccgaggaca cgcttcgcct cacctattac      180

acgcagcccg cccttctgac ggtcagtgtg gccgtgtggc gcgccctggt tgatcgcgtc      240

gatattcagc cgctcgcggt ggccggccac agcctcggcg aatactcggc gctcgtcgcg      300

gccaagagca tttccttcgc ggacgcggtg aaactcgtgt atcagcgcgg aaagctgatg      360

gacgaggcgt atccggcggg gcagggcacc atggcggcgg tcctggggct cgacgaggag      420

ccgcttcgag aggtgtgcaa gcgcgcgagc gaggaaacgg gcgagattgt cgagttggcg      480

aacgtgaact gccctgggca gattgtcatt tcgggggcca aggccgccgt ggaacgcgcc      540

tctcttctgg cgaaggaggc cggagctcgc cgagtgatgc ccctcaacgt cagcgggccg      600

tttcactcga gcctgatgca gccagccgcc gatcggctgg gggcgctcct cgacgagatc      660

gagtttgcgg acgccgagac gcccgtggtg gcgaacgtgg acgggcatcc gcggcggatg      720

gcgtccgatc tgcgcgatgc gctgaagaag caactcgtga tgccggtccg cttcgtggac      780

tgcgtgctgt cgatgaagcg attgggcgtg gattgcgtcg tggagttggg gcccgggacg      840

gtgctcagcg ggctggtgcg caaaatcgac aagtcgcttg agacggccca cgccgaggat      900

ccggcgacgc tggatgaggt gtgcgcgctg ttgacgcgtg gaggtgaaag cggtgagtga      960


<210>   190
<211>   307
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   190
Ile Ala Phe Leu Phe Pro Gly Gln Gly Ser Gln Lys Val Gly Met Gly 
                5                   10                  15      

Ala Thr Leu Phe Ala Glu Asp Ser Leu Ala Lys Glu Val Leu Glu Arg 
            20                  25                  30          

Ala Asp Lys Ala Leu Gly Phe Pro Leu Ser Glu Ile Ile Glu His Gly 
        35                  40                  45              

Pro Glu Glu Lys Leu Lys Gln Thr Ala Tyr Ala Gln Pro Ala Leu Val 
    50                  55                  60                  

Thr Met Ser Thr Ala Val Leu Gln Leu Phe Arg Asp Ala Gly Ile Gln 
65                  70                  75                  80  

Ala Asp Phe Val Ala Gly His Ser Leu Gly Glu Tyr Ser Ala Leu Val 
                85                  90                  95      

Ala Cys Lys Ser Leu Thr Phe Glu Asp Ala Val Thr Leu Val His Gln 
            100                 105                 110         

Arg Gly Thr Leu Met Glu Glu Ala Val Pro Gln Gly Gln Gly Ala Met 
        115                 120                 125             

Ala Ala Val Leu Gly Leu Asn Lys Glu Glu Leu Glu Glu Val Ala Ser 
    130                 135                 140                 

Glu Ile Ala Ala Asp Gly Glu Val Ala Glu Leu Ala Asn Leu Asn Cys 
145                 150                 155                 160 

Pro Gly Gln Ile Val Leu Ser Gly Thr Ala Lys Gly Ile Glu Gln Ala 
                165                 170                 175     

Ala Val Leu Ala Lys Gln Lys Gly Ala Lys Arg Val Leu Pro Leu Ala 
            180                 185                 190         

Val Ser Gly Pro Phe His Ser Ser Leu Met Lys Pro Ala Ala Asp Gln 
        195                 200                 205             

Phe Lys Gln Ala Leu Glu Gln Ala Pro Phe Ala Asn Pro Thr Val Pro 
    210                 215                 220                 

Leu Ile Ala Asn Val Thr Ala Glu Val Thr Asp Ala Pro Glu Val Ile 
225                 230                 235                 240 

Arg Glu Gln Leu Ala Glu Gln Ile Tyr Ser Pro Val Arg Phe Glu Glu 
                245                 250                 255     

Ser Val Arg Arg Met Ile Glu Leu Gly Val Asp Thr Phe Ile Glu Ile 
            260                 265                 270         

Gly Ala Gly Asn Val Leu Cys Gly Leu Val Arg Lys Ile Asp Arg Asn 
        275                 280                 285             

Leu Arg Thr Phe Ala Val Ser Asp Arg Glu Ser Phe Glu Lys Met Ala 
    290                 295                 300                 

Ala Ala Leu 
305         

<210>   191
<211>   300
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   191
Val Ala Phe Leu Phe Pro Gly Gln Gly Ser Gln Ser Val Gly Met Gly 
                5                   10                  15      

Ser Glu Leu Leu Ser Glu Glu Lys Ala Lys Glu Ile Phe Asp Glu Ala 
            20                  25                  30          

Asp Glu Arg Leu Gly Tyr Ser Leu Ser Ser Ile Met Phe Glu Gly Pro 
        35                  40                  45              

Glu Glu Lys Leu Arg Arg Thr Glu Asn Thr Gln Pro Ala Leu Leu Thr 
    50                  55                  60                  

Met Ser Thr Ala Val Leu Ser Leu Val Arg Glu Tyr Gly Ile Lys Pro 
65                  70                  75                  80  

Asp Tyr Thr Ala Gly His Ser Leu Gly Glu Tyr Ser Ala Leu Val Ala 
                85                  90                  95      

Ser Gly Ser Leu Thr Phe Ala Asp Ala Val Tyr Ala Val His His Arg 
            100                 105                 110         

Gly Leu Phe Met Glu Glu Ala Val Pro Phe Gly Glu Gly Ala Met Ala 
        115                 120                 125             

Ala Ile Leu Gly Met Glu Arg Asp Glu Leu Glu Gln Val Thr Lys Arg 
    130                 135                 140                 

Val Thr Glu Ala Gly Ala Val Val Glu Leu Ala Asn Leu Asn Cys Pro 
145                 150                 155                 160 

Gly Gln Ile Val Ile Ser Gly Ser Ala Glu Gly Val Glu Gln Ala Ser 
                165                 170                 175     

Glu Glu Ala Lys Glu Ala Gly Ala Lys Arg Val Ile Pro Leu Gln Val 
            180                 185                 190         

Ser Gly Pro Phe His Ser Ser Leu Met Lys Pro Ala Ala Glu Lys Leu 
        195                 200                 205             

Glu Ala Val Leu Ala Asp Leu Ala Ile Ala Asp Ala Ala Pro Pro Val 
    210                 215                 220                 

Ile Ala Asn Val Thr Ala Asp Leu Val Gln Lys Ala Ala Asp Ile Arg 
225                 230                 235                 240 

Ser Ser Leu Ile Glu Gln Val Tyr Ser Pro Val Arg Trp Glu Asp Thr 
                245                 250                 255     

Val Arg Arg Met Leu Glu Leu Gly Val Asp Thr Phe Val Glu Ile Gly 
            260                 265                 270         

Ser Gly Asn Val Leu Ser Gly Leu Val Arg Lys Val Gln Arg Arg Val 
        275                 280                 285             

Asn Val Phe Ser Val Ser Asp Arg Ala Ser Ile Glu 
    290                 295                 300 

<210>   192
<211>   301
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   192
Ile Ala Phe Leu Phe Pro Gly Gln Gly Ser Gln Phe Ile Gly Met Gly 
                5                   10                  15      

Lys Glu Leu Tyr Glu Gln Val Pro Ala Ala Lys Arg Leu Phe Asp Glu 
            20                  25                  30          

Ala Asp Glu Thr Leu Glu Thr Lys Leu Ser Ser Leu Ile Phe Glu Gly 
        35                  40                  45              

Asp Ala Glu Glu Leu Thr Leu Thr Tyr Asn Ala Gln Pro Ala Leu Leu 
    50                  55                  60                  

Thr Thr Ser Ile Ala Val Leu Glu Lys Phe Lys Glu Ser Gly Ile Thr 
65                  70                  75                  80  

Pro Asp Phe Thr Ala Gly His Ser Leu Gly Glu Tyr Ser Ala Leu Val 
                85                  90                  95      

Ala Ala Gly Ala Leu Ser Phe Lys Asp Ala Val Tyr Thr Val Arg Lys 
            100                 105                 110         

Arg Gly Glu Phe Met Asn Glu Ala Val Pro Ala Gly Glu Gly Ala Met 
        115                 120                 125             

Ala Ala Ile Leu Gly Met Asp Ala Glu Ala Leu Lys Gln Val Thr Asp 
    130                 135                 140                 

Lys Val Thr Glu Glu Gly Asn Leu Val Gln Leu Ala Asn Leu Asn Cys 
145                 150                 155                 160 

Pro Gly Gln Ile Val Ile Ser Gly Thr Ala Lys Gly Val Glu Leu Ala 
                165                 170                 175     

Ser Glu Leu Ala Lys Glu Asn Gly Ala Lys Arg Ala Ile Pro Leu Glu 
            180                 185                 190         

Val Ser Gly Pro Phe His Ser Glu Leu Met Lys Pro Ala Ala Glu Lys 
        195                 200                 205             

Leu Lys Glu Val Leu Asp Ala Cys Asp Ile Lys Asp Ala Asp Val Pro 
    210                 215                 220                 

Val Ile Ser Asn Val Ser Ala Asp Val Met Thr Glu Lys Ala Asp Ile 
225                 230                 235                 240 

Lys Glu Lys Leu Ile Glu Gln Leu Tyr Ser Pro Val Arg Phe Glu Glu 
                245                 250                 255     

Ser Ile Asn Lys Leu Ile Ala Glu Gly Val Thr Thr Phe Ile Glu Ile 
            260                 265                 270         

Gly Pro Gly Lys Val Leu Ser Gly Leu Val Lys Lys Val Asn Arg Arg 
        275                 280                 285             

Leu Lys Thr Ile Ala Val Ser Asp Pro Glu Thr Ile Glu 
    290                 295                 300     

<210>   193
<211>   296
<212>   PRT
<213>   Bacillus sp. SG-1

<400>   193
Ile Ala Phe Val Phe Pro Gly Gln Gly Ser Gln Lys Ala Gly Met Gly 
                5                   10                  15      

Lys Glu Leu Ser Glu Lys Phe Pro Gln Val Glu Glu Tyr Phe Lys Lys 
            20                  25                  30          

Ala Asp Gln Arg Leu Gly Phe Asp Leu Ser Thr Leu Ile Phe Glu Gly 
        35                  40                  45              

Pro Gln Asp Lys Leu Thr Leu Thr Glu Asn Ala Gln Pro Ala Leu Leu 
    50                  55                  60                  

Thr Thr Ser Ile Ala Phe Leu Gln Met Leu Glu Ser Glu Gly Val Lys 
65                  70                  75                  80  

Pro Asp Tyr Thr Ala Gly His Ser Leu Gly Glu Tyr Ser Ala Leu Val 
                85                  90                  95      

Ala Ala Gly Ala Ile Ser Phe Glu Asp Gly Val Tyr Ala Val Arg Lys 
            100                 105                 110         

Arg Gly Glu Tyr Met Glu Glu Ala Val Pro Ala Gly Glu Gly Thr Met 
        115                 120                 125             

Ala Ala Val Leu Gly Met Gly Arg Asp Gln Leu Ser Glu Ile Thr Glu 
    130                 135                 140                 

Arg Ile Ser Ala Glu Gly Asn His Val Gly Leu Ala Asn Leu Asn Cys 
145                 150                 155                 160 

Pro Gly Gln Ile Val Ile Ser Gly Ser Phe Arg Gly Val Glu Leu Ala 
                165                 170                 175     

Ser Asp Leu Ala Lys Glu Glu Gly Ala Lys Arg Val Leu Pro Leu Gln 
            180                 185                 190         

Val Ser Gly Pro Phe His Ser Ser Met Met Lys Pro Ala Ala Glu Asn 
        195                 200                 205             

Phe Ser Gly Val Leu Asp Glu Ile Ala Ile Arg Asp Ala Glu Val Pro 
    210                 215                 220                 

Val Ile Ala Asn Val Asn Ala Glu Pro Met Ile Ser Ala Ser Glu Ile 
225                 230                 235                 240 

Lys Glu Arg Leu Ile Gln Gln Leu Tyr Ser Pro Val Leu Trp Glu Asp 
                245                 250                 255     

Thr Val Val Lys Leu Leu Asp Ala Gly Val Asp Thr Phe Ile Glu Ile 
            260                 265                 270         

Gly Pro Gly Lys Val Leu Ser Gly Leu Ile Lys Lys Val Asn Arg Arg 
        275                 280                 285             

Val Asn Thr Phe Ser Ile Ser Asp 
    290                 295     

<210>   194
<211>   307
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   194
Ile Ala Phe Leu Phe Pro Gly Gln Gly Ser Gln Thr Val Gly Met Ala 
                5                   10                  15      

Lys Asp Ala Ala Glu His Asp Asp Arg Ala Arg Ala Val Ile Ala Glu 
            20                  25                  30          

Ala Asp Glu Arg Leu Gly Phe Ala Leu Ser Lys Leu Met Phe Asn Gly 
        35                  40                  45              

Pro Gln Glu Glu Leu Thr Leu Thr Tyr Asn Ala Gln Pro Ala Leu Leu 
    50                  55                  60                  

Thr Ala Ser Ile Ala Leu Leu Gln Leu Val Asp Gly Ala Gly Leu Lys 
65                  70                  75                  80  

Ala Asp Tyr Val Ala Gly His Ser Leu Gly Glu Tyr Thr Ala Leu Val 
                85                  90                  95      

Ala Ala Gly Ala Met Ser Phe Ala Asp Ala Val Tyr Ala Val Arg Arg 
            100                 105                 110         

Arg Gly Glu Leu Met Asp Glu Ala Val Pro Ala Gly Glu Gly Thr Met 
        115                 120                 125             

Ala Ala Val Leu Gly Met Asp Ala Asp Ala Leu Glu Ala Val Thr Asn 
    130                 135                 140                 

Glu Ile Ala Ala Gln Gly Asp Pro Val Glu Pro Ala Asn Phe Asn Cys 
145                 150                 155                 160 

Pro Gly Gln Ile Val Ile Ser Gly Ser Lys Ala Gly Val Glu Lys Ala 
                165                 170                 175     

Ala Gln Leu Leu Lys Glu Arg Gly Ala Lys Arg Val Ile Pro Leu Glu 
            180                 185                 190         

Val Ser Gly Pro Phe His Ser Ala Leu Met Lys Pro Ala Ala Glu Lys 
        195                 200                 205             

Leu Lys Ala Val Leu Asp Ser Leu Val Ile Arg Asp Ala Val Ile Pro 
    210                 215                 220                 

Val Val Ala Asn Val Thr Ala Glu Pro Val Thr Lys Lys Glu Asp Ile 
225                 230                 235                 240 

Ala Arg Leu Leu Ile Glu Gln Leu Tyr Ser Pro Val Arg Trp Glu Gln 
                245                 250                 255     

Ser Val Arg Thr Leu Leu Ser Leu Gly Val Asp Thr Phe Val Glu Ile 
            260                 265                 270         

Gly Pro Gly Lys Val Leu Ser Gly Leu Val Lys Lys Ile Asp Arg Asn 
        275                 280                 285             

Ala Arg Val Tyr Ala Val Asn Asp Leu Ala Ser Phe Glu Ala Thr Val 
    290                 295                 300                 

Ala Ala Leu 
305         

<210>   195
<211>   319
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   195
Met Asn Val Ala Phe Val Phe Pro Gly Gln Gly Ala Gln Tyr Val Gly 
                5                   10                  15      

Met Gly Arg Ala Ile Phe Asp Glu Tyr Pro Val Ala Arg Ala Leu Leu 
            20                  25                  30          

Glu Glu Ala Asp Glu Ala Leu Gly Met Lys Leu Ser Asp Ile Ile Phe 
        35                  40                  45              

Glu Gly Pro Glu Asp Thr Leu Arg Leu Thr Tyr Tyr Thr Gln Pro Ala 
    50                  55                  60                  

Leu Leu Thr Val Ser Val Ala Val Trp Arg Ala Leu Val Asp Arg Val 
65                  70                  75                  80  

Asp Ile Gln Pro Leu Ala Val Ala Gly His Ser Leu Gly Glu Tyr Ser 
                85                  90                  95      

Ala Leu Val Ala Ala Lys Ser Ile Ser Phe Ala Asp Ala Val Lys Leu 
            100                 105                 110         

Val Tyr Gln Arg Gly Lys Leu Met Asp Glu Ala Tyr Pro Ala Gly Gln 
        115                 120                 125             

Gly Thr Met Ala Ala Val Leu Gly Leu Asp Glu Glu Pro Leu Arg Glu 
    130                 135                 140                 

Val Cys Lys Arg Ala Ser Glu Glu Thr Gly Glu Ile Val Glu Leu Ala 
145                 150                 155                 160 

Asn Val Asn Cys Pro Gly Gln Ile Val Ile Ser Gly Ala Lys Ala Ala 
                165                 170                 175     

Val Glu Arg Ala Ser Leu Leu Ala Lys Glu Ala Gly Ala Arg Arg Val 
            180                 185                 190         

Met Pro Leu Asn Val Ser Gly Pro Phe His Ser Ser Leu Met Gln Pro 
        195                 200                 205             

Ala Ala Asp Arg Leu Gly Ala Leu Leu Asp Glu Ile Glu Phe Ala Asp 
    210                 215                 220                 

Ala Glu Thr Pro Val Val Ala Asn Val Asp Gly His Pro Arg Arg Met 
225                 230                 235                 240 

Ala Ser Asp Leu Arg Asp Ala Leu Lys Lys Gln Leu Val Met Pro Val 
                245                 250                 255     

Arg Phe Val Asp Cys Val Ile Ser Met Lys Arg Leu Gly Val Asp Cys 
            260                 265                 270         

Val Val Glu Leu Gly Pro Gly Thr Val Leu Ser Gly Leu Val Arg Lys 
        275                 280                 285             

Ile Asp Lys Ser Leu Glu Thr Ala His Ala Glu Asp Pro Ala Thr Leu 
    290                 295                 300                 

Asp Glu Val Cys Ala Leu Leu Thr Arg Gly Gly Glu Ser Gly Glu 
305                 310                 315                 

<210>   196
<211>   319
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   196
Met Asn Val Ala Phe Val Phe Pro Gly Gln Gly Ala Gln Tyr Val Gly 
                5                   10                  15      

Met Gly Arg Ala Ile Phe Asp Glu Tyr Pro Val Ala Arg Ala Leu Leu 
            20                  25                  30          

Glu Glu Ala Asp Glu Ala Leu Gly Met Lys Leu Ser Asp Ile Ile Phe 
        35                  40                  45              

Glu Gly Pro Glu Asp Thr Leu Arg Leu Thr Tyr Tyr Thr Gln Pro Ala 
    50                  55                  60                  

Leu Leu Thr Val Ser Val Ala Val Trp Arg Ala Leu Ile Asp Arg Val 
65                  70                  75                  80  

Asp Ile Gln Pro Leu Ala Val Ala Gly His Ser Leu Gly Glu Tyr Ser 
                85                  90                  95      

Ala Leu Val Ala Ala Lys Ser Ile Ser Phe Ala Asp Ala Val Lys Leu 
            100                 105                 110         

Val Tyr Gln Arg Gly Lys Leu Met Asp Glu Ala Tyr Pro Ala Gly Gln 
        115                 120                 125             

Gly Thr Met Ala Ala Val Leu Gly Leu Asp Glu Glu Pro Leu Arg Glu 
    130                 135                 140                 

Val Cys Lys Arg Ala Ser Glu Glu Thr Gly Glu Ile Val Glu Leu Ala 
145                 150                 155                 160 

Asn Val Asn Cys Pro Gly Gln Ile Val Ile Ser Gly Ala Lys Ala Ala 
                165                 170                 175     

Val Glu Arg Ala Ser Leu Leu Ala Lys Glu Ala Gly Ala Arg Arg Val 
            180                 185                 190         

Met Pro Leu Asn Val Ser Gly Pro Phe His Ser Ser Leu Met Gln Pro 
        195                 200                 205             

Ala Ala Asp Arg Leu Gly Ala Leu Leu Asp Glu Ile Glu Phe Ala Asp 
    210                 215                 220                 

Ala Glu Thr Pro Val Val Ala Asn Val Asp Gly His Pro Arg Arg Met 
225                 230                 235                 240 

Ala Ser Asp Leu Arg Asp Ala Leu Lys Lys Gln Leu Val Met Pro Val 
                245                 250                 255     

Arg Phe Val Asp Cys Val Leu Ser Met Lys Arg Leu Gly Val Asp Cys 
            260                 265                 270         

Val Val Glu Leu Gly Pro Gly Thr Val Leu Ser Gly Leu Val Arg Lys 
        275                 280                 285             

Ile Asp Lys Ser Leu Glu Thr Ala His Ala Glu Asp Pro Ala Thr Leu 
    290                 295                 300                 

Asp Glu Val Cys Ala Leu Leu Thr Arg Gly Gly Glu Ser Gly Glu 
305                 310                 315                 

<210>   197
<211>   319
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   197
Met Asn Val Ala Phe Val Phe Pro Gly Gln Gly Ala Gln Tyr Val Gly 
                5                   10                  15      

Met Gly Arg Ala Ile Phe Asp Glu Tyr Pro Val Ala Arg Ala Leu Leu 
            20                  25                  30          

Glu Glu Ala Asp Glu Ala Leu Gly Met Lys Leu Ser Asp Ile Ile Phe 
        35                  40                  45              

Glu Gly Pro Glu Asp Thr Leu Arg Leu Thr Tyr Tyr Thr Gln Pro Ala 
    50                  55                  60                  

Leu Leu Thr Val Ser Val Ala Val Trp Arg Ala Leu Val Asp Arg Val 
65                  70                  75                  80  

Asp Ile Gln Pro Leu Ala Val Ala Gly His Ser Leu Gly Glu Tyr Ser 
                85                  90                  95      

Ala Leu Val Ala Ala Lys Ser Ile Ser Phe Ala Asp Ala Val Lys Leu 
            100                 105                 110         

Val Tyr Gln Arg Gly Lys Leu Met Asp Glu Ala Tyr Pro Ala Gly Gln 
        115                 120                 125             

Gly Thr Met Ala Ala Val Leu Gly Leu Asp Glu Glu Pro Leu Arg Glu 
    130                 135                 140                 

Val Cys Lys Arg Ala Ser Glu Glu Thr Gly Glu Ile Val Glu Leu Ala 
145                 150                 155                 160 

Asn Val Asn Cys Pro Gly Gln Ile Val Ile Ser Gly Ala Lys Ala Ala 
                165                 170                 175     

Val Glu Arg Ala Ser Leu Leu Ala Lys Glu Ala Gly Ala Arg Arg Val 
            180                 185                 190         

Met Pro Leu Asn Val Ser Gly Pro Phe His Ser Ser Leu Met Gln Pro 
        195                 200                 205             

Ala Ala Asp Arg Leu Gly Ala Leu Leu Asp Glu Ile Glu Phe Ala Asp 
    210                 215                 220                 

Ala Glu Thr Pro Val Val Ala Asn Val Asp Gly His Pro Arg Arg Met 
225                 230                 235                 240 

Ala Ser Asp Leu Arg Asp Ala Leu Lys Lys Gln Leu Val Met Pro Val 
                245                 250                 255     

Arg Phe Val Asp Cys Val Leu Ser Met Arg Arg Leu Gly Val Asp Cys 
            260                 265                 270         

Val Val Glu Leu Gly Pro Gly Thr Val Leu Ser Gly Leu Val Arg Lys 
        275                 280                 285             

Ile Asp Lys Ser Leu Glu Thr Ala His Ala Glu Asp Pro Ala Thr Leu 
    290                 295                 300                 

Asp Glu Val Cys Ala Leu Leu Thr Arg Gly Gly Glu Ser Gly Glu 
305                 310                 315                 

<210>   198
<211>   319
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   198
Met Asn Val Ala Phe Val Phe Pro Gly Gln Gly Ala Gln Tyr Val Gly 
                5                   10                  15      

Met Gly Arg Ala Ile Phe Asp Glu Tyr Pro Val Ala Arg Ala Leu Leu 
            20                  25                  30          

Glu Glu Ala Asp Glu Ala Leu Gly Met Lys Leu Ser Asp Ile Ile Phe 
        35                  40                  45              

Glu Gly Pro Glu Asp Thr Leu Arg Leu Thr Tyr Tyr Thr Gln Pro Ala 
    50                  55                  60                  

Leu Leu Thr Val Ser Val Ala Val Trp Arg Ala Leu Val Asp Arg Val 
65                  70                  75                  80  

Asp Ile Gln Pro Leu Ala Val Ala Gly His Ser Leu Gly Glu Tyr Ser 
                85                  90                  95      

Ala Leu Val Ala Ala Lys Ser Ile Ser Phe Ala Asp Ala Val Lys Leu 
            100                 105                 110         

Val Tyr Gln Arg Gly Lys Leu Met Asp Glu Ala Tyr Pro Ala Gly Gln 
        115                 120                 125             

Gly Thr Met Ala Ala Val Leu Gly Leu Asp Glu Glu Pro Leu Lys Glu 
    130                 135                 140                 

Val Cys Lys Arg Ala Ser Glu Glu Thr Gly Glu Ile Val Glu Leu Ala 
145                 150                 155                 160 

Asn Val Asn Cys Pro Gly Gln Ile Val Ile Ser Gly Ala Lys Ala Ala 
                165                 170                 175     

Val Glu Arg Ala Ser Leu Leu Ala Lys Glu Ala Gly Ala Arg Arg Val 
            180                 185                 190         

Met Pro Leu Asn Val Ser Gly Pro Phe His Ser Ser Leu Met Gln Pro 
        195                 200                 205             

Ala Ala Asp Arg Leu Gly Ala Leu Leu Asp Glu Ile Glu Phe Ala Asp 
    210                 215                 220                 

Ala Glu Thr Pro Val Val Ala Asn Val Asp Gly His Pro Arg Arg Met 
225                 230                 235                 240 

Ala Ser Asp Leu Arg Asp Ala Leu Lys Lys Gln Leu Val Met Pro Val 
                245                 250                 255     

Arg Phe Val Asp Cys Val Leu Ser Met Lys Arg Leu Gly Val Asp Cys 
            260                 265                 270         

Val Val Glu Leu Gly Pro Gly Thr Val Leu Ser Gly Leu Val Arg Lys 
        275                 280                 285             

Ile Asp Lys Ser Leu Glu Thr Ala His Ala Glu Asp Pro Ala Thr Leu 
    290                 295                 300                 

Asp Glu Val Cys Ala Leu Leu Thr Arg Gly Gly Glu Ser Gly Glu 
305                 310                 315                 

<210>   199
<211>   319
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   199
Met Asn Val Ala Phe Val Phe Pro Gly Gln Gly Ala Gln Tyr Val Gly 
                5                   10                  15      

Met Gly Arg Ala Ile Phe Asp Glu Tyr Pro Val Ala Arg Ala Leu Leu 
            20                  25                  30          

Glu Glu Ala Asp Glu Ala Leu Gly Met Lys Leu Ser Asp Ile Ile Phe 
        35                  40                  45              

Glu Gly Pro Glu Asp Thr Leu Arg Leu Thr Tyr Tyr Thr Gln Pro Ala 
    50                  55                  60                  

Leu Leu Thr Val Ser Val Ala Val Trp Arg Ala Leu Val Asp Arg Val 
65                  70                  75                  80  

Asp Ile Gln Pro Leu Ala Val Ala Gly His Ser Leu Gly Glu Tyr Ser 
                85                  90                  95      

Ala Leu Val Ala Ala Lys Ser Ile Ser Phe Ala Asp Ala Val Lys Leu 
            100                 105                 110         

Val Tyr Gln Arg Gly Lys Leu Met Asp Glu Ala Tyr Pro Ala Gly Gln 
        115                 120                 125             

Gly Thr Met Ala Ala Val Leu Gly Leu Asp Glu Glu Pro Leu Arg Glu 
    130                 135                 140                 

Val Cys Lys Arg Ala Ser Glu Glu Thr Gly Glu Ile Val Glu Leu Ala 
145                 150                 155                 160 

Asn Val Asn Cys Pro Gly Gln Ile Val Ile Ser Gly Ala Lys Ala Ala 
                165                 170                 175     

Val Glu Arg Ala Ser Leu Leu Ala Lys Glu Ala Gly Ala Arg Arg Val 
            180                 185                 190         

Met Pro Leu Asn Val Ser Gly Pro Phe His Ser Ser Leu Met Gln Pro 
        195                 200                 205             

Ala Ala Asp Arg Leu Gly Ala Leu Leu Asp Glu Ile Glu Phe Ala Asp 
    210                 215                 220                 

Ala Glu Thr Pro Val Val Ala Asn Val Asp Gly His Pro Arg Arg Met 
225                 230                 235                 240 

Ala Ser Asp Leu Arg Asp Ala Leu Lys Lys Gln Leu Val Met Pro Val 
                245                 250                 255     

Arg Phe Val Asp Cys Val Leu Ser Met Lys Arg Leu Gly Val Asp Cys 
            260                 265                 270         

Val Val Glu Leu Gly Pro Gly Thr Val Leu Ser Gly Leu Val Arg Lys 
        275                 280                 285             

Ile Asp Lys Ser Leu Glu Thr Ala His Ala Glu Asp Pro Ala Thr Ile 
    290                 295                 300                 

Asp Glu Val Cys Ala Leu Leu Thr Arg Gly Gly Glu Ser Gly Glu 
305                 310                 315                 

<210>   200
<211>   960
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   200
atgaacgtcg cattcgtgtt tccaggacaa ggcgcccagt acgtcggcat ggggcgagcc       60

atctttgacg agtatcccgt ggcgcgcgcg cttctcgagg aagccgacga ggcgctcggc      120

atgaaattgt cggacatcat cttcgagggt cccgaggaca cgcttcgcct cacctattac      180

acgcagcccg cccttctgac ggtcagtgtg gccgtgtggc gcgccctggt tgatcgcgtc      240

gatattcagc cgctcgcggt ggccggccac agcctcggcg aatactcggc gctcgtcgcg      300

gccaagagca tttccttcgc ggacgcggtg aaactcgtgt atcagcgcgg aaagctgatg      360

gacgaggcgt atccggcggg gcagggcacc atggcggcgg tcctggggct cgacgaggag      420

ccgcttcgag aggtgtgcaa gcgcgcgagc gaggaaacgg gcgagattgt cgagttggcg      480

aacgtgaact gccctgggca gattgtcatt tcgggggcca aggccgccgt ggaacgcgcc      540

tctcttctgg cgaaggaggc cggagctcgc cgagtgatgc ccctcaacgt cagcgggccg      600

tttcactcga gcctgatgca gccagccgcc gatcggctgg gggcgctcct cgacgagatc      660

gagtttgcgg acgccgagac gcccgtggtg gcgaacgtgg acgggcatcc gcggcggatg      720

gcgtccgatc tgcgcgatgc gctgaagaag caactcgtga tgccggtccg cttcgtggac      780

tgcgtgattt cgatgaagcg attgggcgtg gattgcgtcg tggagttggg gcccgggacg      840

gtgctcagcg ggctggtgcg caaaatcgac aagtcgcttg agacggccca cgccgaggat      900

ccggcgacgc tggatgaggt gtgcgcgctg ttgacgcgtg gaggtgaaag cggtgagtga      960


<210>   201
<211>   960
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   201
atgaacgtcg cattcgtgtt tccaggacaa ggcgcccagt acgtcggcat ggggcgagcc       60

atctttgacg agtatcccgt ggcgcgcgcg cttctcgagg aagccgacga ggcgctcggc      120

atgaaattgt cggacatcat cttcgagggt cccgaggaca cgcttcgcct cacctattac      180

acgcagcccg cccttctgac ggtcagtgtg gccgtgtggc gcgccctgat tgatcgcgtc      240

gatattcagc cgctcgcggt ggccggccac agcctcggcg aatactcggc gctcgtcgcg      300

gccaagagca tttccttcgc ggacgcggtg aaactcgtgt atcagcgcgg aaagctgatg      360

gacgaggcgt atccggcggg gcagggcacc atggcggcgg tcctggggct cgacgaggag      420

ccgcttcgag aggtgtgcaa gcgcgcgagc gaggaaacgg gcgagattgt cgagttggcg      480

aacgtgaact gccctgggca gattgtcatt tcgggggcca aggccgccgt ggaacgcgcc      540

tctcttctgg cgaaggaggc cggagctcgc cgagtgatgc ccctcaacgt cagcgggccg      600

tttcactcga gcctgatgca gccagccgcc gatcggctgg gggcgctcct cgacgagatc      660

gagtttgcgg acgccgagac gcccgtggtg gcgaacgtgg acgggcatcc gcggcggatg      720

gcgtccgatc tgcgcgatgc gctgaagaag caactcgtga tgccggtccg cttcgtggac      780

tgcgtgctgt cgatgaagcg attgggcgtg gattgcgtcg tggagttggg gcccgggacg      840

gtgctcagcg ggctggtgcg caaaatcgac aagtcgcttg agacggccca cgccgaggat      900

ccggcgacgc tggatgaggt gtgcgcgctg ttgacgcgtg gaggtgaaag cggtgagtga      960


<210>   202
<211>   960
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   202
atgaacgtcg cattcgtgtt tccaggacaa ggcgcccagt acgtcggcat ggggcgagcc       60

atctttgacg agtatcccgt ggcgcgcgcg cttctcgagg aagccgacga ggcgctcggc      120

atgaaattgt cggacatcat cttcgagggt cccgaggaca cgcttcgcct cacctattac      180

acgcagcccg cccttctgac ggtcagtgtg gccgtgtggc gcgccctggt tgatcgcgtc      240

gatattcagc cgctcgcggt ggccggccac agcctcggcg aatactcggc gctcgtcgcg      300

gccaagagca tttccttcgc ggacgcggtg aaactcgtgt atcagcgcgg aaagctgatg      360

gacgaggcgt atccggcggg gcagggcacc atggcggcgg tcctggggct cgacgaggag      420

ccgcttcgag aggtgtgcaa gcgcgcgagc gaggaaacgg gcgagattgt cgagttggcg      480

aacgtgaact gccctgggca gattgtcatt tcgggggcca aggccgccgt ggaacgcgcc      540

tctcttctgg cgaaggaggc cggagctcgc cgagtgatgc ccctcaacgt cagcgggccg      600

tttcactcga gcctgatgca gccagccgcc gatcggctgg gggcgctcct cgacgagatc      660

gagtttgcgg acgccgagac gcccgtggtg gcgaacgtgg acgggcatcc gcggcggatg      720

gcgtccgatc tgcgcgatgc gctgaagaag caactcgtga tgccggtccg cttcgtggac      780

tgcgtgctgt cgatgcgtcg attgggcgtg gattgcgtcg tggagttggg gcccgggacg      840

gtgctcagcg ggctggtgcg caaaatcgac aagtcgcttg agacggccca cgccgaggat      900

ccggcgacgc tggatgaggt gtgcgcgctg ttgacgcgtg gaggtgaaag cggtgagtga      960


<210>   203
<211>   960
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   203
atgaacgtcg cattcgtgtt tccaggacaa ggcgcccagt acgtcggcat ggggcgagcc       60

atctttgacg agtatcccgt ggcgcgcgcg cttctcgagg aagccgacga ggcgctcggc      120

atgaaattgt cggacatcat cttcgagggt cccgaggaca cgcttcgcct cacctattac      180

acgcagcccg cccttctgac ggtcagtgtg gccgtgtggc gcgccctggt tgatcgcgtc      240

gatattcagc cgctcgcggt ggccggccac agcctcggcg aatactcggc gctcgtcgcg      300

gccaagagca tttccttcgc ggacgcggtg aaactcgtgt atcagcgcgg aaagctgatg      360

gacgaggcgt atccggcggg gcagggcacc atggcggcgg tcctggggct cgacgaggag      420

ccgcttaaag aggtgtgcaa gcgcgcgagc gaggaaacgg gcgagattgt cgagttggcg      480

aacgtgaact gccctgggca gattgtcatt tcgggggcca aggccgccgt ggaacgcgcc      540

tctcttctgg cgaaggaggc cggagctcgc cgagtgatgc ccctcaacgt cagcgggccg      600

tttcactcga gcctgatgca gccagccgcc gatcggctgg gggcgctcct cgacgagatc      660

gagtttgcgg acgccgagac gcccgtggtg gcgaacgtgg acgggcatcc gcggcggatg      720

gcgtccgatc tgcgcgatgc gctgaagaag caactcgtga tgccggtccg cttcgtggac      780

tgcgtgctgt cgatgaagcg attgggcgtg gattgcgtcg tggagttggg gcccgggacg      840

gtgctcagcg ggctggtgcg caaaatcgac aagtcgcttg agacggccca cgccgaggat      900

ccggcgacgc tggatgaggt gtgcgcgctg ttgacgcgtg gaggtgaaag cggtgagtga      960


<210>   204
<211>   960
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   204
atgaacgtcg cattcgtgtt tccaggacaa ggcgcccagt acgtcggcat ggggcgagcc       60

atctttgacg agtatcccgt ggcgcgcgcg cttctcgagg aagccgacga ggcgctcggc      120

atgaaattgt cggacatcat cttcgagggt cccgaggaca cgcttcgcct cacctattac      180

acgcagcccg cccttctgac ggtcagtgtg gccgtgtggc gcgccctggt tgatcgcgtc      240

gatattcagc cgctcgcggt ggccggccac agcctcggcg aatactcggc gctcgtcgcg      300

gccaagagca tttccttcgc ggacgcggtg aaactcgtgt atcagcgcgg aaagctgatg      360

gacgaggcgt atccggcggg gcagggcacc atggcggcgg tcctggggct cgacgaggag      420

ccgcttcgag aggtgtgcaa gcgcgcgagc gaggaaacgg gcgagattgt cgagttggcg      480

aacgtgaact gccctgggca gattgtcatt tcgggggcca aggccgccgt ggaacgcgcc      540

tctcttctgg cgaaggaggc cggagctcgc cgagtgatgc ccctcaacgt cagcgggccg      600

tttcactcga gcctgatgca gccagccgcc gatcggctgg gggcgctcct cgacgagatc      660

gagtttgcgg acgccgagac gcccgtggtg gcgaacgtgg acgggcatcc gcggcggatg      720

gcgtccgatc tgcgcgatgc gctgaagaag caactcgtga tgccggtccg cttcgtggac      780

tgcgtgctgt cgatgaagcg attgggcgtg gattgcgtcg tggagttggg gcccgggacg      840

gtgctcagcg ggctggtgcg caaaatcgac aagtcgcttg agacggccca cgccgaggat      900

ccggcgacga ttgatgaggt gtgcgcgctg ttgacgcgtg gaggtgaaag cggtgagtga      960


<210>   205
<211>   176
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   205
Met Thr Pro Val Leu Ser Val Leu Val His Asn Lys Pro Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Ala Leu Phe Met Arg Lys Gly Phe Asn Ile Gln Ser 
            20                  25                  30          

Leu Thr Val Cys Ile Thr Glu Asn Pro Glu Ile Ser Arg Met Thr Ile 
        35                  40                  45              

Val Met Ser Asp Met Asp Glu Ala Ala Leu Glu Gln Val Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Ile Asp Val Leu Lys Val Thr Asp Leu Thr Asp Gln 
65                  70                  75                  80  

Ala Met Val Ala Arg Glu Leu Ala Leu Ile Arg Val Ser Ser Pro Ile 
                85                  90                  95      

Ala Glu Arg Ala Val Ile His Ser Leu Ile Glu Pro Phe Arg Ala Asn 
            100                 105                 110         

Ile Val Asp Val Gly Arg Glu Thr Val Thr Val Gln Val Thr Gly Asp 
        115                 120                 125             

Ala Glu Lys Ile Asp Ala Leu Ile Ala Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Arg Glu Leu Ala Arg Thr Gly Leu Thr Ala Leu Pro Arg Glu Ala Ala 
145                 150                 155                 160 

Ser Ser Ala Asp Pro Lys Arg Ala Gly Glu Ala Gln Val Leu His Ile 
                165                 170                 175     

<210>   206
<211>   531
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   206
atgacgcctg tcctgtcggt gctcgtgcac aacaaacccg gggtcctcaa ccgcatcacc       60

gcgctcttca tgcgcaaggg attcaacatc cagagcctca ccgtctgcat cacggaaaat      120

ccggagattt cgcgcatgac gattgtcatg agcgacatgg acgaggctgc gctggagcag      180

gtgatcaagc agcttcacaa acagatcgac gtgctgaagg tgacggatct cacggatcag      240

gcgatggtcg cacgtgagct ggcgctcatc cgggtgtcga gccccatcgc cgagcgggcg      300

gtcatccatt cgctcatcga gccgttccgg gcgaacatcg tcgatgttgg gcgagagacg      360

gtgacggtgc aggtcacggg cgatgcggaa aagatcgacg cgctcatcgc gctgctcagg      420

ccgtatggca ttcgagaatt ggcgcgcacg gggttgacgg cgctgccgcg cgaggcggcg      480

tcctcggctg acccgaagcg cgccggagag gcccaggtcc tccacatcta a               531


<210>   207
<211>   159
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   207
Met Arg Arg Ile Ile Thr Met Thr Val Asn Asn Arg Pro Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Gly Leu Phe Thr Lys Arg His Tyr Asn Ile Glu Ser 
            20                  25                  30          

Ile Thr Val Gly His Thr Glu Ile Glu Gly Ile Ser Arg Met Thr Phe 
        35                  40                  45              

Val Val Asn Val Asp Asp Glu Arg Thr Ala Glu Gln Ile Ile Lys Gln 
    50                  55                  60                  

Leu Asn Lys Gln Ile Asp Val Leu Lys Val Asn Asp Ile Thr Asp Gln 
65                  70                  75                  80  

Ala Ile Val Ala Arg Glu Leu Ala Leu Ile Lys Val Ala Ala Pro Pro 
                85                  90                  95      

Ala Val Arg Gln Glu Ile Tyr Thr Leu Ile Glu Pro Phe Arg Ala Ser 
            100                 105                 110         

Ile Val Asp Val Ser Lys Asp Ser Leu Val Ile Gln Val Thr Gly Glu 
        115                 120                 125             

Pro Glu Lys Val Glu Ala Leu Ile Glu Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Lys Glu Val Ala Arg Thr Gly Thr Thr Ala Phe Thr Arg Gly Ala 
145                 150                 155                 

<210>   208
<211>   157
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   208
Met Lys Arg Thr Ile Thr Ala Leu Val Asn Asn Thr Ser Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Gly Leu Phe Ala Arg Arg His Phe Asn Ile Glu Ser 
            20                  25                  30          

Ile Thr Val Gly Val Thr Glu Asn Pro Thr Val Ser Arg Met Thr Phe 
        35                  40                  45              

Val Val Ile Val Asp Asn Gln Lys Asn Ile Glu Gln Val Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Val Asp Val Leu Lys Val Lys Asp Ile Thr Asp Glu 
65                  70                  75                  80  

Ala Ile Val Ala Arg Glu Leu Ala Leu Ile Lys Val Val Ala Ser Pro 
                85                  90                  95      

Gln Gln Arg Gly Glu Ile Ala Ala Val Val Asn Pro Phe Arg Ala Ser 
            100                 105                 110         

Ile Ile Asp Ile Gly Arg Glu Ser Met Thr Val Gln Ile Thr Gly Asp 
        115                 120                 125             

His Gln Lys Val Glu Thr Phe Ile Asp Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Lys Glu Leu Ala Arg Thr Gly Ile Thr Ala Phe Lys Arg 
145                 150                 155         

<210>   209
<211>   167
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   209
Met Arg Arg Ile Ile Thr Met Thr Val Asn Asn Arg Pro Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Gly Leu Phe Thr Lys Arg His Tyr Asn Ile Glu Ser 
            20                  25                  30          

Ile Thr Val Gly His Thr Glu Ile Asp Gly Val Ser Arg Met Thr Phe 
        35                  40                  45              

Val Val Asn Val Asp Asp Glu Arg Ile Ala Glu Gln Ile Ile Lys Gln 
    50                  55                  60                  

Leu Asn Lys Gln Ile Asp Val Leu Lys Val Ser Asp Ile Thr Asp Gln 
65                  70                  75                  80  

Ala Ile Val Ala Arg Glu Leu Ala Leu Val Lys Val Ala Ala Ala Pro 
                85                  90                  95      

Ala Thr Arg Gln Glu Ile Tyr Thr Leu Ile Glu Pro Phe Arg Ala Ser 
            100                 105                 110         

Ile Val Asp Val Ser Lys Asp Ser Leu Val Ile Gln Val Thr Gly Glu 
        115                 120                 125             

Pro Glu Lys Val Glu Ala Leu Ile Glu Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Lys Glu Val Ala Arg Thr Gly Thr Thr Ala Phe Thr Arg Gly Ala Gln 
145                 150                 155                 160 

Lys Ala Gly Ser Asn Gln Lys 
                165         

<210>   210
<211>   167
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   210
Met Lys Arg Thr Ile Thr Val Leu Val Asn Asn Lys Ser Gly Val Leu 
                5                   10                  15      

Asn Arg Met Thr Gly Leu Phe Ala Arg Arg Gln Tyr Asn Ile Asp Ser 
            20                  25                  30          

Ile Thr Val Gly Val Thr Glu Asn Pro Thr Ile Ser Arg Met Thr Phe 
        35                  40                  45              

Val Val Phe Val Asp Ser Met Glu Asn Val Glu Gln Met Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Val Asp Val Leu Lys Ile Lys Asp Ile Thr Asp Glu 
65                  70                  75                  80  

Ala Ile Val Glu Arg Glu Leu Ala Leu Val Arg Val Gly Ala Thr Pro 
                85                  90                  95      

Gln Gln Arg Gly Glu Ile Ala Ser Leu Ala Glu Thr Phe Arg Ala Gln 
            100                 105                 110         

Ala Val Asp Ile Gly Lys Glu Ser Met Thr Leu Gln Ile Thr Gly Asn 
        115                 120                 125             

Asn Glu Lys Ile Glu Ala Phe Ile Glu Leu Val Lys Pro Tyr Gly Ile 
    130                 135                 140                 

Gln Glu Leu Ala Arg Thr Gly Val Thr Ala Val Asn Arg Ser Ser Lys 
145                 150                 155                 160 

Val Ser Thr Asp Thr Ser Arg 
                165         

<210>   211
<211>   156
<212>   PRT
<213>   Bacillus anthracis str. Ames

<400>   211
Met Lys Arg Ile Val Thr Ala Thr Val Arg Asn Gln Ser Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Gly Val Met Thr Arg Arg His Phe Asn Ile Glu Ser 
            20                  25                  30          

Ile Ser Val Gly His Thr Glu Ser Ser Asp Ile Ser Arg Met Thr Ile 
        35                  40                  45              

Val Val His Val Glu Asn Glu Gln Gln Val Glu Gln Leu Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Ile Asp Val Leu Lys Val Ser Asp Ile Thr Glu Glu 
65                  70                  75                  80  

Ala Met Ile Ala Arg Glu Leu Ala Leu Ile Lys Val Ala Thr Ser Val 
                85                  90                  95      

Ala Arg Ala Glu Leu Tyr Ser Leu Ile Glu Pro Phe Arg Ala Ala Val 
            100                 105                 110         

Ile Asp Val Gly Lys Asp Ser Ile Val Val Gln Val Thr Gly Thr Gln 
        115                 120                 125             

Glu Lys Val Glu Ala Leu Ile Glu Leu Leu Arg Pro Tyr Gly Leu Lys 
    130                 135                 140                 

Glu Ile Ala Arg Thr Gly Val Thr Ala Phe Thr Arg 
145                 150                 155     

<210>   212
<211>   176
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   212
Met Thr Pro Val Leu Ser Val Leu Val His Asn Lys Pro Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Ala Leu Phe Met Arg Lys Gly Phe Asn Ile Gln Ser 
            20                  25                  30          

Leu Thr Val Cys Ile Thr Glu Asn Pro Glu Ile Ser Arg Met Thr Ile 
        35                  40                  45              

Val Met Ser Asp Met Asp Glu Ala Ala Leu Glu Gln Val Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Ile Asp Val Leu Lys Val Thr Asp Leu Thr Asp Gln 
65                  70                  75                  80  

Ala Met Val Ala Arg Glu Leu Ala Leu Ile Arg Val Ser Ser Pro Ile 
                85                  90                  95      

Ala Glu Arg Ala Val Ile His Ser Leu Ile Glu Pro Phe Arg Ala Asn 
            100                 105                 110         

Ile Val Asp Val Gly Arg Glu Thr Val Thr Val Gln Val Thr Gly Asp 
        115                 120                 125             

Ala Glu Lys Ile Asp Ala Leu Ile Ala Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Arg Glu Leu Ala Arg Thr Gly Leu Thr Ala Leu Pro Arg Glu Ala Ala 
145                 150                 155                 160 

Ser Ser Ala Asp Pro Lys Lys Ala Gly Glu Ala Gln Val Leu His Ile 
                165                 170                 175     

<210>   213
<211>   176
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   213
Met Thr Pro Val Leu Ser Val Leu Val His Asn Lys Pro Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Ala Leu Phe Met Arg Lys Gly Phe Asn Ile Gln Ser 
            20                  25                  30          

Leu Thr Val Cys Ile Thr Glu Asn Pro Glu Ile Ser Arg Met Thr Ile 
        35                  40                  45              

Val Met Ser Asp Met Asp Glu Ala Ala Leu Glu Gln Val Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Ile Asp Val Leu Lys Val Thr Asp Leu Thr Asp Gln 
65                  70                  75                  80  

Ala Met Val Ala Arg Glu Leu Ala Leu Ile Arg Val Ser Ser Pro Ile 
                85                  90                  95      

Ala Glu Arg Ala Val Ile His Ser Leu Ile Glu Pro Phe Arg Ala Asn 
            100                 105                 110         

Ile Val Asp Val Gly Arg Glu Thr Val Thr Val Gln Val Thr Gly Asp 
        115                 120                 125             

Ala Glu Lys Ile Asp Ala Leu Ile Ala Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Arg Glu Leu Ala Arg Thr Gly Leu Thr Ala Leu Pro Arg Glu Ala Ala 
145                 150                 155                 160 

Ser Ser Ala Asp Pro Lys Arg Ala Gly Glu Ala Gln Ile Leu His Ile 
                165                 170                 175     

<210>   214
<211>   176
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   214
Met Thr Pro Val Leu Ser Val Leu Val His Asn Lys Pro Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Ala Leu Phe Met Arg Lys Gly Phe Asn Ile Gln Ser 
            20                  25                  30          

Leu Thr Val Cys Ile Thr Glu Asn Pro Glu Ile Ser Arg Met Thr Ile 
        35                  40                  45              

Val Met Ser Asp Met Asp Glu Ala Ala Leu Glu Gln Val Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Ile Asp Val Leu Lys Val Thr Asp Leu Thr Asp Gln 
65                  70                  75                  80  

Ala Met Val Ala Arg Glu Leu Ala Leu Ile Arg Val Ser Ser Pro Ile 
                85                  90                  95      

Ala Glu Arg Ala Val Ile His Ser Leu Ile Glu Pro Phe Arg Ala Asn 
            100                 105                 110         

Ile Val Asp Val Gly Arg Glu Thr Val Thr Val Gln Val Thr Gly Glu 
        115                 120                 125             

Ala Glu Lys Ile Asp Ala Leu Ile Ala Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Arg Glu Leu Ala Arg Thr Gly Leu Thr Ala Leu Pro Arg Glu Ala Ala 
145                 150                 155                 160 

Ser Ser Ala Asp Pro Lys Arg Ala Gly Glu Ala Gln Val Leu His Ile 
                165                 170                 175     

<210>   215
<211>   176
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   215
Met Thr Pro Val Leu Ser Val Leu Val His Asn Lys Pro Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Ala Leu Phe Met Arg Lys Gly Phe Asn Ile Gln Ser 
            20                  25                  30          

Leu Thr Val Cys Ile Thr Glu Asn Pro Glu Ile Ser Arg Met Thr Ile 
        35                  40                  45              

Val Met Ser Asp Met Asp Glu Ala Ala Leu Glu Gln Val Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Ile Asp Val Leu Lys Val Thr Asp Leu Thr Asp Gln 
65                  70                  75                  80  

Ala Met Val Ala Arg Glu Leu Ala Leu Ile Arg Val Ser Ser Pro Ile 
                85                  90                  95      

Ala Glu Arg Ala Val Ile His Ser Leu Ile Glu Pro Phe Arg Ala Asn 
            100                 105                 110         

Ile Val Asp Val Gly Arg Glu Thr Val Thr Val Gln Val Thr Gly Asp 
        115                 120                 125             

Ala Glu Lys Ile Asp Ala Leu Ile Ala Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Arg Glu Leu Ala Arg Thr Gly Leu Thr Ala Leu Pro Arg Glu Ala Ala 
145                 150                 155                 160 

Ser Ser Ala Asp Pro Lys Arg Ala Gly Glu Ala Gln Val Leu His Leu 
                165                 170                 175     

<210>   216
<211>   176
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   216
Met Thr Pro Val Leu Ser Val Leu Val His Asn Lys Pro Gly Val Leu 
                5                   10                  15      

Asn Arg Ile Thr Ala Leu Phe Met Arg Lys Gly Phe Asn Ile Gln Ser 
            20                  25                  30          

Leu Thr Val Cys Ile Thr Glu Asn Pro Glu Ile Ser Arg Met Thr Ile 
        35                  40                  45              

Val Met Ser Asp Met Asp Glu Ala Ala Leu Glu Gln Val Ile Lys Gln 
    50                  55                  60                  

Leu His Lys Gln Ile Asp Val Leu Lys Val Thr Asp Leu Thr Asp Gln 
65                  70                  75                  80  

Ala Met Val Ala Arg Glu Leu Ala Leu Ile Arg Val Ser Ser Pro Ile 
                85                  90                  95      

Ala Glu Arg Ala Val Ile His Ser Leu Ile Glu Pro Phe Arg Ala Asn 
            100                 105                 110         

Ile Val Asp Val Gly Arg Glu Thr Val Thr Val Gln Val Thr Gly Asp 
        115                 120                 125             

Ala Glu Lys Ile Asp Ala Leu Ile Ala Leu Leu Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Arg Glu Leu Ala Arg Thr Gly Leu Thr Ala Leu Pro Arg Glu Ala Ala 
145                 150                 155                 160 

Ser Ser Ala Asp Pro Lys Arg Ala Gly Glu Ala Asn Val Leu His Ile 
                165                 170                 175     

<210>   217
<211>   531
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   217
atgacgcctg tcctgtcggt gctcgtgcac aacaaacccg gggtcctcaa ccgcatcacc       60

gcgctcttca tgcgcaaggg attcaacatc cagagcctca ccgtctgcat cacggaaaat      120

ccggagattt cgcgcatgac gattgtcatg agcgacatgg acgaggctgc gctggagcag      180

gtgatcaagc agcttcacaa acagatcgac gtgctgaagg tgacggatct cacggatcag      240

gcgatggtcg cacgtgagct ggcgctcatc cgggtgtcga gccccatcgc cgagcgggcg      300

gtcatccatt cgctcatcga gccgttccgg gcgaacatcg tcgatgttgg gcgagagacg      360

gtgacggtgc aggtcacggg cgatgcggaa aagatcgacg cgctcatcgc gctgctcagg      420

ccgtatggca ttcgagaatt ggcgcgcacg gggttgacgg cgctgccgcg cgaggcggcg      480

tcctcggctg acccgaagaa agccggagag gcccaggtcc tccacatcta a               531


<210>   218
<211>   531
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   218
atgacgcctg tcctgtcggt gctcgtgcac aacaaacccg gggtcctcaa ccgcatcacc       60

gcgctcttca tgcgcaaggg attcaacatc cagagcctca ccgtctgcat cacggaaaat      120

ccggagattt cgcgcatgac gattgtcatg agcgacatgg acgaggctgc gctggagcag      180

gtgatcaagc agcttcacaa acagatcgac gtgctgaagg tgacggatct cacggatcag      240

gcgatggtcg cacgtgagct ggcgctcatc cgggtgtcga gccccatcgc cgagcgggcg      300

gtcatccatt cgctcatcga gccgttccgg gcgaacatcg tcgatgttgg gcgagagacg      360

gtgacggtgc aggtcacggg cgatgcggaa aagatcgacg cgctcatcgc gctgctcagg      420

ccgtatggca ttcgagaatt ggcgcgcacg gggttgacgg cgctgccgcg cgaggcggcg      480

tcctcggctg acccgaagcg cgccggagag gcccagattc tccacatcta a               531


<210>   219
<211>   531
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   219
atgacgcctg tcctgtcggt gctcgtgcac aacaaacccg gggtcctcaa ccgcatcacc       60

gcgctcttca tgcgcaaggg attcaacatc cagagcctca ccgtctgcat cacggaaaat      120

ccggagattt cgcgcatgac gattgtcatg agcgacatgg acgaggctgc gctggagcag      180

gtgatcaagc agcttcacaa acagatcgac gtgctgaagg tgacggatct cacggatcag      240

gcgatggtcg cacgtgagct ggcgctcatc cgggtgtcga gccccatcgc cgagcgggcg      300

gtcatccatt cgctcatcga gccgttccgg gcgaacatcg tcgatgttgg gcgagagacg      360

gtgacggtgc aggtcacggg cgaagcggaa aagatcgacg cgctcatcgc gctgctcagg      420

ccgtatggca ttcgagaatt ggcgcgcacg gggttgacgg cgctgccgcg cgaggcggcg      480

tcctcggctg acccgaagcg cgccggagag gcccaggtcc tccacatcta a               531


<210>   220
<211>   531
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   220
atgacgcctg tcctgtcggt gctcgtgcac aacaaacccg gggtcctcaa ccgcatcacc       60

gcgctcttca tgcgcaaggg attcaacatc cagagcctca ccgtctgcat cacggaaaat      120

ccggagattt cgcgcatgac gattgtcatg agcgacatgg acgaggctgc gctggagcag      180

gtgatcaagc agcttcacaa acagatcgac gtgctgaagg tgacggatct cacggatcag      240

gcgatggtcg cacgtgagct ggcgctcatc cgggtgtcga gccccatcgc cgagcgggcg      300

gtcatccatt cgctcatcga gccgttccgg gcgaacatcg tcgatgttgg gcgagagacg      360

gtgacggtgc aggtcacggg cgatgcggaa aagatcgacg cgctcatcgc gctgctcagg      420

ccgtatggca ttcgagaatt ggcgcgcacg gggttgacgg cgctgccgcg cgaggcggcg      480

tcctcggctg acccgaagcg cgccggagag gcccaggtcc tccacttata a               531


<210>   221
<211>   531
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   221
atgacgcctg tcctgtcggt gctcgtgcac aacaaacccg gggtcctcaa ccgcatcacc       60

gcgctcttca tgcgcaaggg attcaacatc cagagcctca ccgtctgcat cacggaaaat      120

ccggagattt cgcgcatgac gattgtcatg agcgacatgg acgaggctgc gctggagcag      180

gtgatcaagc agcttcacaa acagatcgac gtgctgaagg tgacggatct cacggatcag      240

gcgatggtcg cacgtgagct ggcgctcatc cgggtgtcga gccccatcgc cgagcgggcg      300

gtcatccatt cgctcatcga gccgttccgg gcgaacatcg tcgatgttgg gcgagagacg      360

gtgacggtgc aggtcacggg cgatgcggaa aagatcgacg cgctcatcgc gctgctcagg      420

ccgtatggca ttcgagaatt ggcgcgcacg gggttgacgg cgctgccgcg cgaggcggcg      480

tcctcggctg acccgaagcg cgccggagag gccaatgtcc tccacatcta a               531


<210>   222
<211>   365
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   222
Met Lys Gly Thr Asp Gly Met Thr Lys Asn Ile Ala Ile Leu Pro Gly 
                5                   10                  15      

Asp Gly Ile Gly Arg Glu Val Thr Ala Glu Ala Val Lys Leu Ile Gln 
            20                  25                  30          

Val Val Ala Ala Ser Arg Gly Glu Thr Trp Asn Leu Glu Glu Gly Leu 
        35                  40                  45              

Ile Gly Gly Ser Ala Leu Asp Ala Thr Gly Ser Pro Leu Pro Glu Glu 
    50                  55                  60                  

Thr Val Arg Leu Cys Arg Ala Ala Asp Ala Val Leu Leu Gly Ala Val 
65                  70                  75                  80  

Gly Gly Pro Lys Trp Asp His Leu Pro Gly Asp Lys Arg Pro Glu Ala 
                85                  90                  95      

Gly Leu Leu Gly Ile Arg Lys Ala Leu Glu Val Tyr Ala Asn Leu Arg 
            100                 105                 110         

Pro Ile Arg Thr Trp Pro Gly Leu Leu Leu Ala Ser Pro Leu Lys Pro 
        115                 120                 125             

Glu Leu Val Glu Gly Val Asp Phe Ile Ile Val Arg Glu Leu Thr Gly 
    130                 135                 140                 

Gly Leu Tyr Phe Gly Gln Pro Lys Ala Arg Leu Asp Gly Gly Glu Ala 
145                 150                 155                 160 

Val Val Asp Thr Leu His Tyr Thr Arg Ala Glu Ile Arg Arg Val Val 
                165                 170                 175     

Lys Val Ala Phe Glu Leu Ala Lys Gly Arg Gln Gly Arg Leu Thr Ser 
            180                 185                 190         

Val Asp Lys Ala Asn Val Leu Glu Ser Ser Arg Val Trp Arg Glu Val 
        195                 200                 205             

Val Glu Glu Val Ala Ser Glu Tyr Pro Gly Val Leu Val Glu His Leu 
    210                 215                 220                 

Leu Val Asp Asn Ala Ala Met Gln Ile Ile Thr Arg Pro Lys Thr Phe 
225                 230                 235                 240 

Asp Val Ile Val Thr Glu Asn Met Phe Gly Asp Ile Leu Ser Asp Glu 
                245                 250                 255     

Ala Ala Val Ile Thr Gly Ser Ile Gly Met Leu Pro Ser Ala Ser Leu 
            260                 265                 270         

Gly Glu Ala Gly Pro Gly Leu Tyr Glu Pro Val His Gly Ser Ala Pro 
        275                 280                 285             

Asp Ile Ala Gly Gln Gly Leu Ala Asn Pro Leu Ala Thr Phe Leu Ser 
    290                 295                 300                 

Val Ala Leu Met Met Arg His Ser Leu His Leu Pro Glu Ala Ala Asp 
305                 310                 315                 320 

Ala Ile Glu Gln Ala Val His Gly Val Ile Glu Arg Gly Val Arg Thr 
                325                 330                 335     

Arg Asp Leu Ala Arg Ser Gly Glu Ala Phe Val Lys Thr Ala Asp Val 
            340                 345                 350         

Ser Ala Met Val Cys Glu Asp Val Lys Arg Arg Leu Gly 
        355                 360                 365 

<210>   223
<211>   1098
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   223
ttgaaaggga cggatggcat gacaaagaac attgcgatct tgccgggaga cggcatcggc       60

cgagaagtca cggcggaggc ggtcaagctg atccaggtcg tcgccgcgag tcggggggag      120

acgtggaacc tcgaggaagg tctcattggc ggcagcgcgc tggacgcgac aggctcgcca      180

ttgccggaag agacggtgcg gctctgccgc gctgcggacg ccgtgctgct cggcgcggtg      240

ggcggaccga agtgggacca tctccccggc gacaagcgcc ctgaggcagg actgctcggc      300

attcgcaagg cgcttgaggt ctacgcgaat cttcggccca tccggacctg gccagggctg      360

ttgctggcct cgccgctcaa gccggagctt gtcgagggcg tggatttcat catcgtgcgg      420

gagttgacgg gtgggcttta tttcggccag ccgaaggcgc gcctcgatgg cggcgaggcg      480

gtggtggaca cgcttcatta cacgcgcgcc gagattcgcc gcgtggtgaa ggtggccttt      540

gaactcgcga aaggccggca ggggcgcctg acgtcggtcg acaaggcgaa tgtgctcgag      600

tcgagccgcg tgtggcgcga ggtggtggag gaggttgcgt ccgaatatcc cggcgttttg      660

gtggagcatc tgctggtgga caacgccgcc atgcagatca tcacgcggcc gaagacgttc      720

gacgtgatcg tgacggagaa catgtttggc gacattttga gcgacgaggc ggccgtcatc      780

acgggatcca tcggcatgct gccttccgcg agcctcggcg aggcaggacc gggcctgtac      840

gagcccgtgc acggctccgc gccggacatc gccggacagg gcctcgccaa tccgctggcg      900

acgtttctgt ccgtggcgct catgatgcgg cattccctgc acctccccga ggctgcggac      960

gccatcgagc aggcggtgca cggcgtgatt gagcggggcg tccgcacgcg cgatctcgcc     1020

cgaagcggcg aggcgttcgt caagacggcg gacgtcagcg ccatggtttg cgaagacgtg     1080

aaaaggaggc tcggttga                                                   1098


<210>   224
<211>   357
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   224
Met Glu Lys Gln Ile Ala Val Leu Pro Gly Asp Gly Ile Gly Pro Glu 
                5                   10                  15      

Val Thr Asp Ala Ala Ile Glu Val Leu Gln Ala Val Ala Asp Arg Phe 
            20                  25                  30          

Gly His Thr Phe Ser Tyr Lys Lys Ala Leu Leu Gly Gly Cys Ala Ile 
        35                  40                  45              

Asp Glu Val Gly Thr Pro Leu Pro Glu Glu Thr Leu Asp Val Cys Arg 
    50                  55                  60                  

His Ala Asp Gly Ile Leu Leu Gly Ala Val Gly Gly Pro Lys Trp Asp 
65                  70                  75                  80  

Thr Leu Pro Gly His Leu Arg Pro Glu Lys Gly Leu Leu Gly Leu Arg 
                85                  90                  95      

Lys Gly Leu Asn Leu Phe Ala Asn Leu Arg Pro Val Thr Val Tyr Asp 
            100                 105                 110         

Ser Leu Ala Asp Ala Ser Thr Leu Lys Asn Asp Val Ile Asp Gly Val 
        115                 120                 125             

Asp Leu Leu Ile Val Arg Glu Leu Thr Gly Gly Leu Tyr Phe Gly Glu 
    130                 135                 140                 

Pro Arg Glu Arg Arg Gly Glu Gly Glu Thr Glu Glu Val Val Asp Thr 
145                 150                 155                 160 

Leu Leu Tyr Thr Arg Gly Glu Met Arg Arg Ile Ile Arg Lys Ala Phe 
                165                 170                 175     

Glu Leu Ala Met Val Arg Asn Lys His Val Thr Ser Val Asp Lys Ala 
            180                 185                 190         

Asn Val Leu Glu Ser Ser Arg Met Trp Arg Glu Val Ala Asn Glu Val 
        195                 200                 205             

Ala Gln Glu Phe Pro Glu Val Thr Leu Glu His Met Leu Val Asp Asn 
    210                 215                 220                 

Ala Ala Met Gln Leu Ile Arg Arg Pro Lys Gln Phe Asp Val Leu Val 
225                 230                 235                 240 

Thr Glu Asn Leu Phe Gly Asp Ile Leu Ser Asp Glu Ala Ser Met Val 
                245                 250                 255     

Thr Gly Ser Leu Gly Met Leu Pro Ser Ala Ser Leu Thr Ser Asp Gly 
            260                 265                 270         

Pro Gly Leu Tyr Glu Pro Ile His Gly Ser Ala Pro Asp Ile Ala Gly 
        275                 280                 285             

Lys Gly Val Ala Asn Pro Leu Ala Thr Ile Ala Ser Cys Ala Met Met 
    290                 295                 300                 

Leu Lys Tyr Ser Phe Gly Leu His Glu Glu Ala Lys Thr Ile Glu Asp 
305                 310                 315                 320 

Ala Ile Glu Ala Val Leu Lys Gln Gly Tyr Arg Thr Ala Asp Ile Ala 
                325                 330                 335     

Lys Pro Gly Glu Glu Ser Ser Ser Thr Lys Ala Ile Thr Asp Ala Val 
            340                 345                 350         

Val Glu Ala Ile Gln 
        355         

<210>   225
<211>   344
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   225
Ile Ala Val Leu Pro Gly Asp Gly Ile Gly Lys Glu Val Thr Ser Gly 
                5                   10                  15      

Ala Val Glu Val Leu Lys Ala Val Gly Ile Arg Phe Gly His Glu Phe 
            20                  25                  30          

Thr Phe Glu Tyr Gly Leu Ile Gly Gly Ala Ala Ile Asp Glu Ala Gly 
        35                  40                  45              

Thr Pro Leu Pro Glu Glu Thr Leu Arg Leu Cys Arg Glu Ser Asp Ala 
    50                  55                  60                  

Val Leu Leu Gly Ala Val Gly Gly Pro Lys Trp Asp Asp Asn Pro Pro 
65                  70                  75                  80  

His Leu Arg Pro Glu Lys Gly Leu Leu Ala Ile Arg Lys Gln Leu Asp 
                85                  90                  95      

Leu Tyr Ala Asn Leu Arg Pro Val Val Cys Tyr Asp Ser Leu Val Ser 
            100                 105                 110         

Ala Ser Pro Leu Lys Pro Asp Leu Val Gln Gly Val Asp Phe Val Ile 
        115                 120                 125             

Val Arg Glu Leu Thr Gly Gly Ile Tyr Phe Gly Gln Pro Ser Gly Arg 
    130                 135                 140                 

Val Val Glu Asn Gly Glu Glu Lys Ala Val Asp Thr Leu Leu Tyr Lys 
145                 150                 155                 160 

Lys Glu Glu Ile Glu Arg Ile Val Arg Met Ala Phe Ile Leu Ala Arg 
                165                 170                 175     

Gly Arg Lys Lys Lys Val Thr Ser Val Asp Lys Ala Asn Val Leu Ser 
            180                 185                 190         

Ser Ser Arg Leu Trp Arg Glu Val Ala Glu Glu Val Ala Lys Gln Phe 
        195                 200                 205             

Pro Asp Val Thr Leu Glu His Met Leu Val Asp Asn Ala Ala Met Gln 
    210                 215                 220                 

Leu Ile Arg Ala Pro Lys Gln Phe Asp Val Ile Val Thr Glu Asn Met 
225                 230                 235                 240 

Phe Gly Asp Ile Leu Ser Asp Glu Ala Ser Met Leu Ser Gly Ser Leu 
                245                 250                 255     

Gly Met Leu Pro Ser Ala Ser Leu Ser Ala Ser Gly Pro Ser Leu Tyr 
            260                 265                 270         

Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Met Asn Lys Ala 
        275                 280                 285             

Asn Pro Ile Ala Ala Ile Leu Ser Ala Ala Met Met Leu Arg Leu Ser 
    290                 295                 300                 

Phe Gly Leu Thr Ala Glu Ala Glu Ala Val Glu His Ala Val Arg Gln 
305                 310                 315                 320 

Ala Leu Asp Gln Gly Leu Arg Thr Ala Asp Leu Ala Pro Ser Gly Gly 
                325                 330                 335     

Arg Ile Val Ser Thr Asn Glu Met 
            340                 

<210>   226
<211>   358
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   226
Met Lys Lys Arg Ile Ala Val Leu Pro Gly Asp Gly Ile Gly Lys Glu 
                5                   10                  15      

Val Ala Ala Gly Ala Val Glu Val Leu Gln Ala Ala Gly Glu Arg Phe 
            20                  25                  30          

Gly His Thr Phe Glu Phe Ser Tyr Gly Lys Ile Gly Gly Thr Ala Ile 
        35                  40                  45              

Asp Ser Thr Gly Val Pro Leu Pro Asp Glu Thr Val Glu Leu Cys Lys 
    50                  55                  60                  

Ser Ser Asp Ala Ile Leu Leu Gly Ala Val Gly Gly Pro Arg Trp Glu 
65                  70                  75                  80  

Lys Leu His Pro Ser Leu Arg Pro Glu Arg Gly Leu Leu Lys Ile Arg 
                85                  90                  95      

Lys Asp Leu Asn Leu Tyr Ala Asn Leu Arg Pro Thr Ser Tyr Phe Ala 
            100                 105                 110         

Ser Val Ala Asp Ser Ser Pro Leu Arg Lys Glu Val Ile Glu Gly Thr 
        115                 120                 125             

Asp Phe Leu Met Val Arg Glu Leu Thr Gly Gly Leu Tyr Phe Gly Lys 
    130                 135                 140                 

Pro Ser Glu Arg Ala Gly Asn Gly Ser Glu Glu Thr Ala Val Asp Thr 
145                 150                 155                 160 

Leu Phe Tyr Lys Lys Glu Glu Val Gln Arg Val Val Arg Leu Ala Phe 
                165                 170                 175     

Glu Leu Ala Arg Gly Arg Asp Gly Lys Val Thr Ser Val Asp Lys Ala 
            180                 185                 190         

Asn Val Leu Glu Ser Ser Arg Met Trp Arg Glu Thr Ala Glu Glu Ile 
        195                 200                 205             

Ala Ala Gln Tyr Pro Asp Ile Gln Leu Glu His Met Leu Val Asp Asn 
    210                 215                 220                 

Ala Ala Met Gln Ile Ile Lys Asn Pro Lys Gln Phe Asp Val Ile Val 
225                 230                 235                 240 

Thr Glu Asn Met Phe Gly Asp Ile Leu Ser Asp Glu Ala Ser Val Leu 
                245                 250                 255     

Thr Gly Ser Leu Gly Met Leu Pro Ser Ala Ser Leu Ser Glu Gly Gly 
            260                 265                 270         

Pro Tyr Leu Tyr Glu Pro Ile His Gly Ser Ala Pro Asp Ile Glu Gly 
        275                 280                 285             

Lys Gly Ile Ala Asn Pro Val Gly Met Ile Leu Ser Ala Ala Met Met 
    290                 295                 300                 

Leu Arg Leu Ser Phe Gly Met Glu Glu Glu Ala Ala Ala Ile Glu Lys 
305                 310                 315                 320 

Ala Val Ser Asp Val Leu Glu Ser Gly Ile Arg Thr Ala Asp Leu Ala 
                325                 330                 335     

Ser Gly Gly Lys Ala Ala Ser Thr Lys Val Met Thr Glu Glu Ile Lys 
            340                 345                 350         

Ala Ala Leu Leu Asp Asn 
        355             

<210>   227
<211>   344
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   227
Ile Ala Val Leu Pro Gly Asp Gly Ile Gly Lys Glu Val Thr Ser Gly 
                5                   10                  15      

Ala Val Glu Val Leu Lys Ala Val Gly Ile Arg Phe Gly His Glu Phe 
            20                  25                  30          

Thr Phe Glu Tyr Gly Leu Ile Gly Gly Ala Ala Ile Asp Glu Val Gly 
        35                  40                  45              

Thr Pro Leu Pro Glu Glu Thr Leu Arg Leu Cys Gln Gln Ser Asp Ala 
    50                  55                  60                  

Val Leu Leu Gly Ala Val Gly Gly Pro Lys Trp Asp Gln Asn Pro Pro 
65                  70                  75                  80  

His Leu Arg Pro Glu Lys Gly Leu Leu Ala Ile Arg Gln Gln Leu Gly 
                85                  90                  95      

Leu Tyr Ala Asn Leu Arg Pro Val Val Cys Tyr Asp Ser Leu Asp Ser 
            100                 105                 110         

Ala Ser Pro Leu Lys Ser Asp Leu Val Gln Gly Val Asp Phe Ile Ile 
        115                 120                 125             

Val Arg Glu Leu Thr Gly Gly Ile Tyr Phe Gly Gln Pro Ser Gly Arg 
    130                 135                 140                 

Val Val Glu Asn Gly Glu Glu Lys Ala Val Asp Thr Leu Leu Tyr Lys 
145                 150                 155                 160 

Lys Glu Glu Ile Glu Arg Ile Val Arg Met Ala Phe Thr Leu Ala Arg 
                165                 170                 175     

Gly Arg Lys Lys Lys Val Thr Ser Val Asp Lys Ala Asn Val Leu Ser 
            180                 185                 190         

Ser Ser Arg Leu Trp Arg Glu Val Ala Glu Glu Val Ala Lys Gln Phe 
        195                 200                 205             

Pro Asp Val Glu Leu Glu His Met Leu Val Asp Asn Ala Ala Met Gln 
    210                 215                 220                 

Leu Ile Arg Ala Pro Lys Gln Phe Asp Val Ile Val Thr Glu Asn Met 
225                 230                 235                 240 

Phe Gly Asp Ile Leu Ser Asp Glu Ala Ser Met Leu Ser Gly Ser Leu 
                245                 250                 255     

Gly Met Leu Pro Ser Ala Ser Leu Ser Ala Ser Gly Pro Ser Leu Tyr 
            260                 265                 270         

Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Met Arg Lys Ala 
        275                 280                 285             

Asn Pro Ile Ala Ala Ile Leu Ser Ala Ala Met Met Leu Arg Leu Ser 
    290                 295                 300                 

Phe Gly Leu Thr Ala Glu Ala Glu Ala Ile Glu His Ala Val Gln Gln 
305                 310                 315                 320 

Ala Leu Thr Ala Gly Leu Arg Thr Ala Asp Leu Ala Gln Ser Asn Gly 
                325                 330                 335     

Arg Val Val Ser Thr Asp Glu Met 
            340                 

<210>   228
<211>   340
<212>   PRT
<213>   Gloeobacter violaceus PCC 7421

<400>   228
Ile Ala Val Leu Pro Gly Asp Gly Ile Gly Thr Glu Ile Val Gln Val 
                5                   10                  15      

Gly Val Ala Met Leu Glu Ala Ala Ala Arg Arg Phe Asp Phe Ala Phe 
            20                  25                  30          

Asp Phe Glu Glu Ala Pro Ile Gly Gly Ala Ala Ile Asp Ala Thr Gly 
        35                  40                  45              

Glu Pro Leu Pro Ala Ala Thr Leu Glu Leu Cys Lys Ala Ser Asp Ala 
    50                  55                  60                  

Val Phe Leu Gly Ala Val Gly Gly Pro Gln Trp Asp Thr Leu Pro Ser 
65                  70                  75                  80  

Asp Lys Arg Pro Glu Lys Ala Leu Leu Gly Leu Arg Ala Gly Leu Gly 
                85                  90                  95      

Leu Phe Ala Asn Leu Arg Pro Ala Arg Ile Leu Pro Gln Leu Val Ala 
            100                 105                 110         

Ala Ser Ala Leu Lys Pro Glu Val Val Glu Gly Val Asp Ile Leu Val 
        115                 120                 125             

Val Arg Glu Leu Thr Gly Gly Leu Tyr Phe Gly Ile Pro Lys Gly Ile 
    130                 135                 140                 

Phe Pro Glu Lys Lys Gly Gly Arg Arg Gly Val Asn Thr Met Ser Tyr 
145                 150                 155                 160 

Ser Ala Phe Glu Ile Glu Arg Ile Gly Arg Val Ala Phe Glu Ala Ala 
                165                 170                 175     

Arg Glu Arg Arg Gly Lys Leu Cys Ser Val Asp Lys Ala Asn Val Leu 
            180                 185                 190         

Glu Val Ser Gln Leu Trp Arg Glu Val Leu Val Gly Leu Ala Pro Glu 
        195                 200                 205             

Tyr Pro Asp Val Glu Leu Thr His Met Tyr Val Asp Asn Cys Ala Met 
    210                 215                 220                 

Gln Leu Val Arg Arg Pro Arg Gln Phe Asp Thr Ile Val Thr Glu Asn 
225                 230                 235                 240 

Met Phe Gly Asp Ile Leu Ser Asp Glu Ala Ala Met Leu Thr Gly Ser 
                245                 250                 255     

Ile Gly Met Leu Pro Ser Ala Ser Leu Gly Ser Gly Gly Pro Gly Leu 
            260                 265                 270         

Tyr Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Gln Asp Lys 
        275                 280                 285             

Ala Asn Pro Leu Ala Gln Val Leu Ser Gly Ala Met Leu Leu Arg His 
    290                 295                 300                 

Ser Leu Arg Gln Pro Glu Ala Ala Gln Ala Val Glu Arg Ala Val Gln 
305                 310                 315                 320 

Thr Val Leu Glu Gln Gly Tyr Arg Thr Gly Asp Ile Ala Ala Pro Gly 
                325                 330                 335     

Ala Gln Ile Val 
            340 

<210>   229
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   229
Met Lys Gly Thr Asp Gly Met Thr Lys Asn Ile Ala Ile Leu Pro Gly 
                5                   10                  15      

Asp Gly Ile Gly Arg Glu Val Thr Ala Glu Ala Val Lys Leu Ile Gln 
            20                  25                  30          

Val Val Ala Ala Ser Arg Gly Glu Thr Trp Asn Leu Glu Glu Gly Leu 
        35                  40                  45              

Ile Gly Gly Ser Ala Leu Asp Ala Thr Gly Ser Pro Leu Pro Glu Glu 
    50                  55                  60                  

Thr Val Lys Leu Cys Arg Ala Ala Asp Ala Val Leu Leu Gly Ala Val 
65                  70                  75                  80  

Gly Gly Pro Lys Trp Asp His Leu Pro Gly Asp Lys Arg Pro Glu Ala 
                85                  90                  95      

Gly Leu Leu Gly Ile Arg Lys Ala Leu Glu Val Tyr Ala Asn Leu Arg 
            100                 105                 110         

Pro Ile Arg Thr Trp Pro Gly Leu Leu Leu Ala Ser Pro Leu Lys Pro 
        115                 120                 125             

Glu Leu Val Glu Gly Val Asp Phe Ile Ile Val Arg Glu Leu Thr Gly 
    130                 135                 140                 

Gly Leu Tyr Phe Gly Gln Pro Lys Ala Arg Leu Asp Gly Gly Glu Ala 
145                 150                 155                 160 

Val Val Asp Thr Leu His Tyr Thr Arg Ala Glu Ile Arg Arg Val Val 
                165                 170                 175     

Lys Val Ala Phe Glu Leu Ala Lys Gly Arg Gln Gly Arg Leu Thr Ser 
            180                 185                 190         

Val Asp Lys Ala Asn Val Leu Glu Ser Ser Arg Val Trp Arg Glu Val 
        195                 200                 205             

Val Glu Glu Val Ala Ser Glu Tyr Pro Gly Val Leu Val Glu His Leu 
    210                 215                 220                 

Leu Val Asp Asn Ala Ala Met Gln Ile Ile Thr Arg Pro Lys Thr Phe 
225                 230                 235                 240 

Asp Val Ile Val Thr Glu Asn Met Phe Gly Asp Ile Leu Ser Asp Glu 
                245                 250                 255     

Ala Ala Val Ile Thr Gly Ser Ile Gly Met Leu Pro Ser Ala Ser Leu 
            260                 265                 270         

Gly Glu Ala Gly Pro Gly Leu Tyr Glu Pro Val His Gly Ser Ala Pro 
        275                 280                 285             

Asp Ile Ala Gly Gln Gly Leu Ala Asn Pro Leu Ala Thr Phe Leu Ser 
    290                 295                 300                 

Val Ala Leu Met Met Arg His Ser Leu His Leu Pro Glu Ala Ala Asp 
305                 310                 315                 320 

Ala Ile Glu Gln Ala Val His Gly Val Ile Glu Arg Gly Val Arg Thr 
                325                 330                 335     

Arg Asp Leu Ala Arg Ser Gly Glu Ala Phe Val Lys Thr Ala Asp Val 
            340                 345                 350         

Ser Ala Met Val Cys Glu Asp Val Lys Arg Arg Leu Gly 
        355                 360                 365 

<210>   230
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   230
Met Lys Gly Thr Asp Gly Met Thr Lys Asn Ile Ala Ile Leu Pro Gly 
                5                   10                  15      

Asp Gly Ile Gly Arg Glu Val Thr Ala Glu Ala Val Lys Leu Ile Gln 
            20                  25                  30          

Val Val Ala Ala Ser Arg Gly Glu Thr Trp Asn Leu Glu Glu Gly Leu 
        35                  40                  45              

Ile Gly Gly Ser Ala Leu Asp Ala Thr Gly Ser Pro Leu Pro Glu Glu 
    50                  55                  60                  

Thr Val Arg Leu Cys Arg Ala Ala Asp Ala Val Leu Leu Gly Ala Val 
65                  70                  75                  80  

Gly Gly Pro Lys Trp Asp His Leu Pro Gly Asp Lys Arg Pro Glu Ala 
                85                  90                  95      

Gly Leu Leu Gly Ile Arg Lys Ala Leu Glu Val Tyr Ala Asn Leu Arg 
            100                 105                 110         

Pro Ile Arg Thr Trp Pro Gly Leu Leu Leu Ala Ser Pro Leu Lys Pro 
        115                 120                 125             

Glu Leu Val Glu Gly Val Asp Phe Ile Ile Val Arg Glu Leu Thr Gly 
    130                 135                 140                 

Gly Leu Tyr Phe Gly Gln Pro Lys Ala Arg Leu Asp Gly Gly Glu Ala 
145                 150                 155                 160 

Val Val Asp Thr Leu His Tyr Thr Arg Ala Glu Ile Arg Arg Val Val 
                165                 170                 175     

Lys Val Ala Phe Glu Leu Ala Lys Gly Arg Gln Gly Arg Leu Thr Ser 
            180                 185                 190         

Val Asp Lys Ala Asn Val Leu Glu Ser Ser Arg Val Trp Arg Glu Val 
        195                 200                 205             

Val Glu Glu Val Ala Ser Glu Tyr Pro Gly Val Leu Val Glu His Leu 
    210                 215                 220                 

Leu Val Asp Asn Ala Ala Met Gln Ile Ile Thr Arg Pro Lys Thr Phe 
225                 230                 235                 240 

Asp Val Ile Val Thr Glu Asn Met Phe Gly Asp Ile Leu Ser Asp Glu 
                245                 250                 255     

Ala Ala Val Ile Thr Gly Ser Ile Gly Met Leu Pro Ser Ala Ser Leu 
            260                 265                 270         

Gly Glu Ala Gly Pro Gly Leu Tyr Glu Pro Val His Gly Ser Ala Pro 
        275                 280                 285             

Asp Ile Ala Gly Gln Gly Leu Ala Asn Pro Leu Ala Thr Phe Leu Ser 
    290                 295                 300                 

Val Ala Leu Met Met Arg His Ser Leu His Leu Pro Glu Ala Ala Asp 
305                 310                 315                 320 

Ala Ile Glu Gln Ala Val His Gly Val Ile Glu Arg Gly Val Arg Thr 
                325                 330                 335     

Arg Asp Leu Ala Arg Ser Gly Glu Ala Phe Val Lys Thr Ala Asp Val 
            340                 345                 350         

Ser Ala Met Val Cys Glu Asp Val Lys Arg Arg Ile Gly 
        355                 360                 365 

<210>   231
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   231
Met Lys Gly Thr Asp Gly Met Thr Lys Asn Ile Ala Ile Leu Pro Gly 
                5                   10                  15      

Asp Gly Ile Gly Arg Glu Val Thr Ala Glu Ala Val Lys Leu Ile Gln 
            20                  25                  30          

Val Val Ala Ala Ser Arg Gly Glu Thr Trp Asn Leu Glu Glu Gly Leu 
        35                  40                  45              

Ile Gly Gly Ser Ala Leu Asp Ala Thr Gly Ser Pro Leu Pro Glu Glu 
    50                  55                  60                  

Thr Val Arg Leu Cys Arg Ala Ala Asp Ala Val Leu Leu Gly Ala Val 
65                  70                  75                  80  

Gly Gly Pro Lys Trp Asp His Leu Pro Gly Asp Lys Arg Pro Glu Ala 
                85                  90                  95      

Gly Leu Leu Gly Ile Arg Lys Ala Leu Glu Val Tyr Ala Asn Leu Arg 
            100                 105                 110         

Pro Ile Arg Thr Trp Pro Gly Leu Leu Leu Ala Ser Pro Leu Lys Pro 
        115                 120                 125             

Glu Leu Val Glu Gly Val Asp Phe Ile Ile Val Arg Glu Leu Thr Gly 
    130                 135                 140                 

Gly Leu Tyr Phe Gly Gln Pro Lys Ala Arg Leu Asp Gly Gly Glu Ala 
145                 150                 155                 160 

Val Val Asp Thr Leu His Tyr Thr Arg Ala Glu Ile Arg Arg Val Val 
                165                 170                 175     

Lys Val Ala Phe Glu Leu Ala Lys Gly Arg Gln Gly Arg Leu Thr Ser 
            180                 185                 190         

Val Asp Lys Ala Asn Val Leu Glu Ser Ser Arg Val Trp Arg Glu Val 
        195                 200                 205             

Val Glu Glu Val Ala Ser Glu Tyr Pro Gly Val Leu Val Glu His Leu 
    210                 215                 220                 

Leu Val Asp Asn Ala Ala Met Gln Ile Ile Thr Arg Pro Lys Thr Phe 
225                 230                 235                 240 

Asp Val Ile Val Thr Glu Asn Met Phe Gly Asp Ile Leu Ser Asp Glu 
                245                 250                 255     

Ala Ala Val Ile Thr Gly Ser Ile Gly Met Leu Pro Ser Ala Ser Leu 
            260                 265                 270         

Gly Asp Ala Gly Pro Gly Leu Tyr Glu Pro Val His Gly Ser Ala Pro 
        275                 280                 285             

Asp Ile Ala Gly Gln Gly Leu Ala Asn Pro Leu Ala Thr Phe Leu Ser 
    290                 295                 300                 

Val Ala Leu Met Met Arg His Ser Leu His Leu Pro Glu Ala Ala Asp 
305                 310                 315                 320 

Ala Ile Glu Gln Ala Val His Gly Val Ile Glu Arg Gly Val Arg Thr 
                325                 330                 335     

Arg Asp Leu Ala Arg Ser Gly Glu Ala Phe Val Lys Thr Ala Asp Val 
            340                 345                 350         

Ser Ala Met Val Cys Glu Asp Val Lys Arg Arg Leu Gly 
        355                 360                 365 

<210>   232
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   232
Met Lys Gly Thr Asp Gly Met Thr Lys Asn Ile Ala Ile Leu Pro Gly 
                5                   10                  15      

Asp Gly Ile Gly Arg Glu Val Thr Ala Glu Ala Val Lys Leu Ile Gln 
            20                  25                  30          

Val Val Ala Ala Ser Arg Gly Glu Thr Trp Asn Leu Glu Glu Gly Leu 
        35                  40                  45              

Ile Gly Gly Ser Ala Leu Asp Ala Thr Gly Ser Pro Leu Pro Glu Glu 
    50                  55                  60                  

Thr Val Arg Leu Cys Arg Ala Ala Asp Ala Val Leu Leu Gly Ala Val 
65                  70                  75                  80  

Gly Gly Pro Lys Trp Asp His Leu Pro Gly Asp Lys Arg Pro Glu Ala 
                85                  90                  95      

Gly Leu Leu Gly Ile Arg Lys Ala Leu Glu Val Tyr Ala Asn Leu Arg 
            100                 105                 110         

Pro Ile Arg Thr Trp Pro Gly Leu Leu Leu Ala Ser Pro Leu Lys Pro 
        115                 120                 125             

Glu Leu Val Glu Gly Val Asp Phe Ile Ile Val Arg Glu Leu Thr Gly 
    130                 135                 140                 

Gly Leu Tyr Phe Gly Gln Pro Lys Ala Arg Leu Asp Gly Gly Glu Ala 
145                 150                 155                 160 

Val Val Asp Thr Leu His Tyr Thr Arg Ala Glu Ile Arg Arg Val Val 
                165                 170                 175     

Lys Val Ala Phe Glu Leu Ala Lys Gly Arg Gln Gly Arg Leu Thr Ser 
            180                 185                 190         

Val Asp Lys Ala Asn Val Leu Glu Ser Ser Arg Val Trp Arg Glu Val 
        195                 200                 205             

Val Glu Glu Val Ala Ser Glu Tyr Pro Gly Val Leu Val Glu His Leu 
    210                 215                 220                 

Leu Val Asp Asn Ala Ala Met Gln Ile Ile Thr Arg Pro Lys Thr Phe 
225                 230                 235                 240 

Asp Val Ile Val Thr Glu Asn Met Phe Gly Asp Ile Leu Ser Asp Glu 
                245                 250                 255     

Ala Ala Val Ile Thr Gly Ser Ile Gly Met Leu Pro Ser Ala Ser Leu 
            260                 265                 270         

Gly Glu Ala Gly Pro Gly Leu Tyr Glu Pro Val His Gly Ser Ala Pro 
        275                 280                 285             

Asp Ile Ala Gly Gln Gly Leu Ala Asn Pro Leu Ala Thr Phe Leu Ser 
    290                 295                 300                 

Val Ala Leu Met Met Arg His Ser Leu His Leu Pro Glu Ala Ala Asp 
305                 310                 315                 320 

Ala Ile Glu Gln Ala Val His Gly Val Ile Glu Lys Gly Val Arg Thr 
                325                 330                 335     

Arg Asp Leu Ala Arg Ser Gly Glu Ala Phe Val Lys Thr Ala Asp Val 
            340                 345                 350         

Ser Ala Met Val Cys Glu Asp Val Lys Arg Arg Leu Gly 
        355                 360                 365 

<210>   233
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   233
Met Lys Gly Thr Asp Gly Met Thr Lys Asn Ile Ala Ile Leu Pro Gly 
                5                   10                  15      

Asp Gly Ile Gly Arg Glu Val Thr Ala Glu Ala Val Lys Leu Ile Gln 
            20                  25                  30          

Val Val Ala Ala Ser Arg Gly Glu Thr Trp Asn Leu Glu Glu Gly Leu 
        35                  40                  45              

Ile Gly Gly Ser Ala Leu Asp Ala Thr Gly Ser Pro Leu Pro Glu Glu 
    50                  55                  60                  

Thr Val Arg Leu Cys Arg Ala Ala Asp Ala Val Leu Leu Gly Ala Val 
65                  70                  75                  80  

Gly Gly Pro Lys Trp Asp His Leu Pro Gly Asp Lys Arg Pro Glu Ala 
                85                  90                  95      

Gly Leu Leu Gly Ile Arg Lys Ala Leu Glu Val Tyr Ala Asn Leu Arg 
            100                 105                 110         

Pro Ile Arg Thr Trp Pro Gly Leu Leu Leu Ala Ser Pro Leu Lys Pro 
        115                 120                 125             

Glu Leu Val Glu Gly Val Asp Phe Ile Ile Val Arg Glu Leu Thr Gly 
    130                 135                 140                 

Gly Leu Tyr Phe Gly Gln Pro Lys Ala Arg Leu Asp Gly Gly Glu Ala 
145                 150                 155                 160 

Val Val Asp Thr Leu His Tyr Thr Arg Ala Glu Ile Arg Arg Val Val 
                165                 170                 175     

Lys Val Ala Phe Glu Leu Ala Lys Gly Arg Gln Gly Arg Leu Thr Ser 
            180                 185                 190         

Val Asp Lys Ala Asn Val Leu Glu Ser Ser Arg Val Trp Arg Glu Val 
        195                 200                 205             

Val Glu Glu Val Ala Ser Glu Tyr Pro Gly Val Leu Val Asp His Leu 
    210                 215                 220                 

Leu Val Asp Asn Ala Ala Met Gln Ile Ile Thr Arg Pro Lys Thr Phe 
225                 230                 235                 240 

Asp Val Ile Val Thr Glu Asn Met Phe Gly Asp Ile Leu Ser Asp Glu 
                245                 250                 255     

Ala Ala Val Ile Thr Gly Ser Ile Gly Met Leu Pro Ser Ala Ser Leu 
            260                 265                 270         

Gly Glu Ala Gly Pro Gly Leu Tyr Glu Pro Val His Gly Ser Ala Pro 
        275                 280                 285             

Asp Ile Ala Gly Gln Gly Leu Ala Asn Pro Leu Ala Thr Phe Leu Ser 
    290                 295                 300                 

Val Ala Leu Met Met Arg His Ser Leu His Leu Pro Glu Ala Ala Asp 
305                 310                 315                 320 

Ala Ile Glu Gln Ala Val His Gly Val Ile Glu Arg Gly Val Arg Thr 
                325                 330                 335     

Arg Asp Leu Ala Arg Ser Gly Glu Ala Phe Val Lys Thr Ala Asp Val 
            340                 345                 350         

Ser Ala Met Val Cys Glu Asp Val Lys Arg Arg Leu Gly 
        355                 360                 365 

<210>   234
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   234
ttgaaaggga cggatggcat gacaaagaac attgcgatct tgccgggaga cggcatcggc       60

cgagaagtca cggcggaggc ggtcaagctg atccaggtcg tcgccgcgag tcggggggag      120

acgtggaacc tcgaggaagg tctcattggc ggcagcgcgc tggacgcgac aggctcgcca      180

ttgccggaag agacggtgaa actctgccgc gctgcggacg ccgtgctgct cggcgcggtg      240

ggcggaccga agtgggacca tctccccggc gacaagcgcc ctgaggcagg actgctcggc      300

attcgcaagg cgcttgaggt ctacgcgaat cttcggccca tccggacctg gccagggctg      360

ttgctggcct cgccgctcaa gccggagctt gtcgagggcg tggatttcat catcgtgcgg      420

gagttgacgg gtgggcttta tttcggccag ccgaaggcgc gcctcgatgg cggcgaggcg      480

gtggtggaca cgcttcatta cacgcgcgcc gagattcgcc gcgtggtgaa ggtggccttt      540

gaactcgcga aaggccggca ggggcgcctg acgtcggtcg acaaggcgaa tgtgctcgag      600

tcgagccgcg tgtggcgcga ggtggtggag gaggttgcgt ccgaatatcc cggcgttttg      660

gtggagcatc tgctggtgga caacgccgcc atgcagatca tcacgcggcc gaagacgttc      720

gacgtgatcg tgacggagaa catgtttggc gacattttga gcgacgaggc ggccgtcatc      780

acgggatcca tcggcatgct gccttccgcg agcctcggcg aggcaggacc gggcctgtac      840

gagcccgtgc acggctccgc gccggacatc gccggacagg gcctcgccaa tccgctggcg      900

acgtttctgt ccgtggcgct catgatgcgg cattccctgc acctccccga ggctgcggac      960

gccatcgagc aggcggtgca cggcgtgatt gagcggggcg tccgcacgcg cgatctcgcc     1020

cgaagcggcg aggcgttcgt caagacggcg gacgtcagcg ccatggtttg cgaagacgtg     1080

aaaaggaggc tcggttga                                                   1098


<210>   235
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   235
ttgaaaggga cggatggcat gacaaagaac attgcgatct tgccgggaga cggcatcggc       60

cgagaagtca cggcggaggc ggtcaagctg atccaggtcg tcgccgcgag tcggggggag      120

acgtggaacc tcgaggaagg tctcattggc ggcagcgcgc tggacgcgac aggctcgcca      180

ttgccggaag agacggtgcg gctctgccgc gctgcggacg ccgtgctgct cggcgcggtg      240

ggcggaccga agtgggacca tctccccggc gacaagcgcc ctgaggcagg actgctcggc      300

attcgcaagg cgcttgaggt ctacgcgaat cttcggccca tccggacctg gccagggctg      360

ttgctggcct cgccgctcaa gccggagctt gtcgagggcg tggatttcat catcgtgcgg      420

gagttgacgg gtgggcttta tttcggccag ccgaaggcgc gcctcgatgg cggcgaggcg      480

gtggtggaca cgcttcatta cacgcgcgcc gagattcgcc gcgtggtgaa ggtggccttt      540

gaactcgcga aaggccggca ggggcgcctg acgtcggtcg acaaggcgaa tgtgctcgag      600

tcgagccgcg tgtggcgcga ggtggtggag gaggttgcgt ccgaatatcc cggcgttttg      660

gtggagcatc tgctggtgga caacgccgcc atgcagatca tcacgcggcc gaagacgttc      720

gacgtgatcg tgacggagaa catgtttggc gacattttga gcgacgaggc ggccgtcatc      780

acgggatcca tcggcatgct gccttccgcg agcctcggcg aggcaggacc gggcctgtac      840

gagcccgtgc acggctccgc gccggacatc gccggacagg gcctcgccaa tccgctggcg      900

acgtttctgt ccgtggcgct catgatgcgg cattccctgc acctccccga ggctgcggac      960

gccatcgagc aggcggtgca cggcgtgatt gagcggggcg tccgcacgcg cgatctcgcc     1020

cgaagcggcg aggcgttcgt caagacggcg gacgtcagcg ccatggtttg cgaagacgtg     1080

aaaaggagga ttggttga                                                   1098


<210>   236
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   236
ttgaaaggga cggatggcat gacaaagaac attgcgatct tgccgggaga cggcatcggc       60

cgagaagtca cggcggaggc ggtcaagctg atccaggtcg tcgccgcgag tcggggggag      120

acgtggaacc tcgaggaagg tctcattggc ggcagcgcgc tggacgcgac aggctcgcca      180

ttgccggaag agacggtgcg gctctgccgc gctgcggacg ccgtgctgct cggcgcggtg      240

ggcggaccga agtgggacca tctccccggc gacaagcgcc ctgaggcagg actgctcggc      300

attcgcaagg cgcttgaggt ctacgcgaat cttcggccca tccggacctg gccagggctg      360

ttgctggcct cgccgctcaa gccggagctt gtcgagggcg tggatttcat catcgtgcgg      420

gagttgacgg gtgggcttta tttcggccag ccgaaggcgc gcctcgatgg cggcgaggcg      480

gtggtggaca cgcttcatta cacgcgcgcc gagattcgcc gcgtggtgaa ggtggccttt      540

gaactcgcga aaggccggca ggggcgcctg acgtcggtcg acaaggcgaa tgtgctcgag      600

tcgagccgcg tgtggcgcga ggtggtggag gaggttgcgt ccgaatatcc cggcgttttg      660

gtggagcatc tgctggtgga caacgccgcc atgcagatca tcacgcggcc gaagacgttc      720

gacgtgatcg tgacggagaa catgtttggc gacattttga gcgacgaggc ggccgtcatc      780

acgggatcca tcggcatgct gccttccgcg agcctcggcg atgcaggacc gggcctgtac      840

gagcccgtgc acggctccgc gccggacatc gccggacagg gcctcgccaa tccgctggcg      900

acgtttctgt ccgtggcgct catgatgcgg cattccctgc acctccccga ggctgcggac      960

gccatcgagc aggcggtgca cggcgtgatt gagcggggcg tccgcacgcg cgatctcgcc     1020

cgaagcggcg aggcgttcgt caagacggcg gacgtcagcg ccatggtttg cgaagacgtg     1080

aaaaggaggc tcggttga                                                   1098


<210>   237
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   237
ttgaaaggga cggatggcat gacaaagaac attgcgatct tgccgggaga cggcatcggc       60

cgagaagtca cggcggaggc ggtcaagctg atccaggtcg tcgccgcgag tcggggggag      120

acgtggaacc tcgaggaagg tctcattggc ggcagcgcgc tggacgcgac aggctcgcca      180

ttgccggaag agacggtgcg gctctgccgc gctgcggacg ccgtgctgct cggcgcggtg      240

ggcggaccga agtgggacca tctccccggc gacaagcgcc ctgaggcagg actgctcggc      300

attcgcaagg cgcttgaggt ctacgcgaat cttcggccca tccggacctg gccagggctg      360

ttgctggcct cgccgctcaa gccggagctt gtcgagggcg tggatttcat catcgtgcgg      420

gagttgacgg gtgggcttta tttcggccag ccgaaggcgc gcctcgatgg cggcgaggcg      480

gtggtggaca cgcttcatta cacgcgcgcc gagattcgcc gcgtggtgaa ggtggccttt      540

gaactcgcga aaggccggca ggggcgcctg acgtcggtcg acaaggcgaa tgtgctcgag      600

tcgagccgcg tgtggcgcga ggtggtggag gaggttgcgt ccgaatatcc cggcgttttg      660

gtggagcatc tgctggtgga caacgccgcc atgcagatca tcacgcggcc gaagacgttc      720

gacgtgatcg tgacggagaa catgtttggc gacattttga gcgacgaggc ggccgtcatc      780

acgggatcca tcggcatgct gccttccgcg agcctcggcg aggcaggacc gggcctgtac      840

gagcccgtgc acggctccgc gccggacatc gccggacagg gcctcgccaa tccgctggcg      900

acgtttctgt ccgtggcgct catgatgcgg cattccctgc acctccccga ggctgcggac      960

gccatcgagc aggcggtgca cggcgtgatt gagaaaggcg tccgcacgcg cgatctcgcc     1020

cgaagcggcg aggcgttcgt caagacggcg gacgtcagcg ccatggtttg cgaagacgtg     1080

aaaaggaggc tcggttga                                                   1098


<210>   238
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   238
ttgaaaggga cggatggcat gacaaagaac attgcgatct tgccgggaga cggcatcggc       60

cgagaagtca cggcggaggc ggtcaagctg atccaggtcg tcgccgcgag tcggggggag      120

acgtggaacc tcgaggaagg tctcattggc ggcagcgcgc tggacgcgac aggctcgcca      180

ttgccggaag agacggtgcg gctctgccgc gctgcggacg ccgtgctgct cggcgcggtg      240

ggcggaccga agtgggacca tctccccggc gacaagcgcc ctgaggcagg actgctcggc      300

attcgcaagg cgcttgaggt ctacgcgaat cttcggccca tccggacctg gccagggctg      360

ttgctggcct cgccgctcaa gccggagctt gtcgagggcg tggatttcat catcgtgcgg      420

gagttgacgg gtgggcttta tttcggccag ccgaaggcgc gcctcgatgg cggcgaggcg      480

gtggtggaca cgcttcatta cacgcgcgcc gagattcgcc gcgtggtgaa ggtggccttt      540

gaactcgcga aaggccggca ggggcgcctg acgtcggtcg acaaggcgaa tgtgctcgag      600

tcgagccgcg tgtggcgcga ggtggtggag gaggttgcgt ccgaatatcc cggcgttttg      660

gtggatcatc tgctggtgga caacgccgcc atgcagatca tcacgcggcc gaagacgttc      720

gacgtgatcg tgacggagaa catgtttggc gacattttga gcgacgaggc ggccgtcatc      780

acgggatcca tcggcatgct gccttccgcg agcctcggcg aggcaggacc gggcctgtac      840

gagcccgtgc acggctccgc gccggacatc gccggacagg gcctcgccaa tccgctggcg      900

acgtttctgt ccgtggcgct catgatgcgg cattccctgc acctccccga ggctgcggac      960

gccatcgagc aggcggtgca cggcgtgatt gagcggggcg tccgcacgcg cgatctcgcc     1020

cgaagcggcg aggcgttcgt caagacggcg gacgtcagcg ccatggtttg cgaagacgtg     1080

aaaaggaggc tcggttga                                                   1098


<210>   239
<211>   481
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   239
Met Arg Arg Arg Glu Lys Glu Ala Arg Leu Met Gly Arg Thr Leu Phe 
                5                   10                  15      

Glu Lys Val Trp Asp Ala His Val Val Lys Glu Leu Pro Asp Gly Gln 
            20                  25                  30          

Thr Leu Leu Tyr Ile Asp Leu His Leu Val His Glu Val Thr Ser Pro 
        35                  40                  45              

Gln Ala Phe Ala Gly Leu Arg Phe Ala Gly Arg Lys Val Arg Arg Pro 
    50                  55                  60                  

Glu Leu Thr Phe Ala Thr Met Asp His Asn Val Pro Thr Val Asn Pro 
65                  70                  75                  80  

Lys Asp Val Arg Asp Ala Ile Ala Arg Lys Gln Ile Glu Thr Leu Glu 
                85                  90                  95      

Gln Asn Cys Arg Glu Phe Gly Val Gln Leu Ala Gly Leu Asp Ser Pro 
            100                 105                 110         

Phe Gln Gly Ile Val His Val Ile Gly Pro Glu Leu Gly Leu Thr Met 
        115                 120                 125             

Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr Ser Thr His Gly 
    130                 135                 140                 

Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser Glu Val Glu His 
145                 150                 155                 160 

Val Leu Ala Thr Gln Cys Leu Trp Gln Ser Arg Pro Lys Thr Met Arg 
                165                 170                 175     

Ile Gln Leu Asn Gly Thr Leu Gln Pro Gly Val Thr Ala Lys Asp Val 
            180                 185                 190         

Ile Leu Gly Leu Ile Ala Lys Tyr Gly Val Asn Phe Gly Thr Gly His 
        195                 200                 205             

Val Val Glu Tyr Ala Gly Ser Leu Ile Pro Glu Leu Ser Met Glu Gln 
    210                 215                 220                 

Arg Met Thr Ile Cys Asn Met Ser Ile Glu Phe Gly Ala Arg Ala Gly 
225                 230                 235                 240 

Met Met Ala Pro Asp Glu Thr Thr Ile Ala Tyr Val Gln Gly Arg Arg 
                245                 250                 255     

Tyr Ala Pro Lys Gly Ala Asp Trp Glu Ala Cys Val Ala Ala Trp Arg 
            260                 265                 270         

Glu Leu Lys Ser Asp Pro Asp Ala Val Phe Asp Val Asp Val Val Phe 
        275                 280                 285             

Asp Val Asn Asp Leu Glu Pro Gln Val Thr Trp Gly Thr Asn Pro Gly 
    290                 295                 300                 

Gln Gly Thr Gly Ile Ser Gly Val Val Pro Asp Pro Lys Asp Ala Lys 
305                 310                 315                 320 

Ser Glu Glu Glu Ala Leu Ala Ile Arg Gln Ala Leu Glu Tyr Met Asp 
                325                 330                 335     

Leu Lys Pro Gly Thr Lys Ile Ser Glu Ile Pro Ile Gln His Val Phe 
            340                 345                 350         

Ile Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu Arg Leu Ala Ala 
        355                 360                 365             

Ser Ile Val Lys Gly Arg Arg Val Ala Asp Gly Val Arg Ala Val Val 
    370                 375                 380                 

Val Pro Gly Ser Lys Gln Val Lys Gln Gln Ala Glu Ala Glu Gly Leu 
385                 390                 395                 400 

His Glu Ile Phe Leu Glu Ala Gly Phe Glu Trp Arg Glu Pro Gly Cys 
                405                 410                 415     

Ser Ala Cys Leu Gly Met Asn Pro Asp Ile Ile Pro Ala Gly Glu Arg 
            420                 425                 430         

Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg Gln Gly Lys Gly 
        435                 440                 445             

Ala Arg Thr His Leu Val Ser Pro Ala Met Ala Ala Ala Ala Ala Ile 
    450                 455                 460                 

Ala Gly His Phe Val Asp Val Arg Glu Leu Thr Ser Glu Gly Val Thr 
465                 470                 475                 480 

Ala 
    

<210>   240
<211>   1446
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   240
ttgcgaagac gtgaaaagga ggctcggttg atggggagga ccctgttcga aaaagtctgg       60

gacgcgcacg tggtcaagga actgccggat ggacagacgc ttctctacat tgacttgcac      120

ctcgtccacg aggtgacgtc gcctcaggcg tttgccggac ttcgtttcgc ggggcgcaag      180

gttcgccggc ccgagctgac gtttgcgacc atggatcaca acgtgccgac ggtcaatccg      240

aaggatgtcc gggacgccat tgcgcgcaag cagatcgaga cgctggagca gaactgccgc      300

gagttcggcg tccaactggc ggggctcgac agccccttcc agggcattgt gcatgtcatc      360

ggcccggagc ttgggctgac catgccgggg aagacgattg tctgcggcga cagccacacg      420

tcgacgcacg gcgcgttcgg cgcgctcgcc tttggcatcg gcacgagcga ggtggaacac      480

gttctcgcca cgcagtgcct ctggcagagc cgaccgaaga ccatgcgcat tcagctgaat      540

ggcacgcttc aaccgggcgt caccgccaag gacgtgatct tgggcctgat tgcgaaatac      600

ggcgtgaatt ttggcacggg ccacgtcgtg gagtacgcgg gcagcctgat cccagagctc      660

agcatggagc agcggatgac catctgcaac atgtccatcg agttcggcgc ccgggcgggc      720

atgatggcgc cggacgagac gaccatcgcc tacgtccagg gccggcgcta tgcgccgaag      780

ggcgcggatt gggaggcgtg cgtcgccgca tggcgcgaac tgaagtccga tcccgacgcc      840

gtcttcgacg tcgacgtggt cttcgatgtg aatgacctcg agccgcaggt gacgtggggc      900

accaatccgg ggcaggggac cggcatcagc ggcgtcgtgc cggatccgaa ggacgcgaag      960

tccgaggagg aggcgctggc cattcgacag gcgcttgagt acatggacct gaagccggga     1020

accaaaatct ccgagatccc catccagcac gtgttcatcg gatcgtgcac caacgcccgc     1080

atcgaggatc tgcgcttggc cgcgagcatc gtcaagggcc ggcgcgtcgc ggatggcgtg     1140

cgcgcggtgg tcgtgccggg atcgaaacag gtgaagcagc aggcggaggc cgaggggctt     1200

cacgagatct tcctcgaagc gggcttcgag tggcgcgagc ccggctgcag cgcgtgtctc     1260

ggcatgaatc ccgacatcat cccggctggg gagcggtgcg catcgacgtc caaccgcaac     1320

ttcgaaggcc ggcagggcaa aggggcccgc acgcacctcg tcagcccggc catggcggcc     1380

gccgcggcca tcgcggggca cttcgtcgac gtgcgcgaac tgacctcgga aggagtgacg     1440

gcgtga                                                                1446


<210>   241
<211>   468
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   241
Lys Thr Ile Ile Glu Lys Ile Trp Asp Ala His Thr Val Ile Gly Glu 
                5                   10                  15      

Glu Gly Lys Pro Ser Leu Leu Tyr Ile Asp Leu His Met Val His Glu 
            20                  25                  30          

Val Thr Ser Pro Gln Ala Phe Glu Gly Leu Arg Leu Ala Gly Arg Pro 
        35                  40                  45              

Val Arg Arg Pro Asp Leu Thr Phe Ala Thr Met Asp His Asn Val Pro 
    50                  55                  60                  

Thr Val Asp Arg Phe Asn Ile Gln Asp Gln Ile Ala Arg Lys Gln Ile 
65                  70                  75                  80  

Glu Thr Leu Glu Ala Asn Cys Lys Glu Phe Gly Ile Glu Ile Ala Gly 
                85                  90                  95      

Leu Asp Ser Pro Asn Asn Gly Ile Val His Val Ile Gly Pro Glu Leu 
            100                 105                 110         

Gly Leu Thr Gln Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr 
        115                 120                 125             

Ser Thr His Gly Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser 
    130                 135                 140                 

Glu Val Glu His Val Leu Ala Thr Gln Thr Leu Trp Gln Ser Lys Pro 
145                 150                 155                 160 

Lys Thr Met Glu Val Arg Val Thr Gly Glu Leu Ala Pro Ser Val Ser 
                165                 170                 175     

Ala Lys Asp Ile Ile Leu Ala Val Ile Ala Lys Tyr Gly Val Asp Phe 
            180                 185                 190         

Gly Thr Gly His Val Ile Glu Phe Thr Gly Glu Ala Ile Arg Ser Leu 
        195                 200                 205             

Ser Met Glu Glu Arg Met Thr Ile Cys Asn Met Ser Ile Glu Ala Gly 
    210                 215                 220                 

Ala Lys Ala Gly Leu Ile Ser Pro Asp Ser Val Thr Phe Glu Tyr Leu 
225                 230                 235                 240 

Arg Gly Arg Pro Asn Ala Pro Lys Gly Glu Ala Phe Asp Val Ala Ile 
                245                 250                 255     

Gln Gln Trp Glu Ala Leu Ala Thr Asp Ala Gly Ala Val Tyr Asp Arg 
            260                 265                 270         

Val Leu Thr Met Asn Ala Ser Glu Ile Glu Pro Met Val Thr Trp Gly 
        275                 280                 285             

Thr Asn Pro Ala Gln Gly Thr Gly Val Ser Gln Val Val Pro Ser Pro 
    290                 295                 300                 

Asp Asp Ala Lys Asp Glu Asn Glu Arg Arg Ala Ile Lys Gln Ser Leu 
305                 310                 315                 320 

Ala Tyr Met Gly Leu Glu Pro Gly Thr Pro Ile Thr Glu Ile Ala Ile 
                325                 330                 335     

Gln His Val Phe Ile Gly Ser Cys Thr Asn Ser Arg Leu Ser Asp Leu 
            340                 345                 350         

Arg Thr Ala Ala Glu Leu Ile Lys Gly Arg Lys Val Ala Asp Gly Val 
        355                 360                 365             

Arg Ala Leu Val Val Pro Gly Ser Gln Gln Val Lys Arg Ala Ala Glu 
    370                 375                 380                 

Lys Glu Gly Leu Asp Glu Ile Phe Lys Glu Ala Gly Phe Glu Trp Arg 
385                 390                 395                 400 

Asp Ser Gly Cys Ser Met Cys Leu Gly Met Asn Pro Asp Thr Val Pro 
                405                 410                 415     

Glu Gly Glu Arg Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg 
            420                 425                 430         

Gln Gly Lys Gly Ala Arg Thr His Leu Val Ser Pro Gln Met Ala Ala 
        435                 440                 445             

Ala Ala Ala Ile Ala Gly His Phe Val Asp Val Arg Thr Phe Gln Ser 
    450                 455                 460                 

Glu Pro Gln Thr 
465             

<210>   242
<211>   467
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   242
Lys Thr Ile Ile Asp Lys Ile Trp Glu Asn His Val Val Tyr Arg Glu 
                5                   10                  15      

Glu Gly Lys Pro Asp Leu Leu Tyr Ile Asp Leu His Leu Val His Glu 
            20                  25                  30          

Val Thr Ser Pro Gln Ala Phe Glu Gly Leu Arg Gln Lys Gly Arg Lys 
        35                  40                  45              

Val Arg Arg Pro Asp Leu Thr Phe Ala Thr Met Asp His Asn Val Pro 
    50                  55                  60                  

Thr Val Asn Arg Phe Val Ile Thr Asp Glu Val Ala Arg Asn Gln Ile 
65                  70                  75                  80  

Ala Ala Leu Glu Arg Asn Cys Arg Glu Phe Gly Ile Pro Leu Ala Asp 
                85                  90                  95      

Leu His Ser Glu Glu Gln Gly Ile Val His Val Ile Gly Pro Glu Leu 
            100                 105                 110         

Gly Leu Thr Gln Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr 
        115                 120                 125             

Ser Thr His Gly Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser 
    130                 135                 140                 

Glu Val Glu His Val Leu Ala Thr Gln Thr Leu Trp Gln His Lys Pro 
145                 150                 155                 160 

Lys Thr Leu Gln Ile Cys Ile Asn Gly Arg Leu Gly Lys Gly Val Thr 
                165                 170                 175     

Ala Lys Asp Val Ile Leu Ala Ile Ile Gly Arg Tyr Gly Val Gly Val 
            180                 185                 190         

Gly Thr Gly Tyr Ile Ile Glu Phe Thr Gly Glu Ala Ile Arg Arg Met 
        195                 200                 205             

Ser Met Glu Glu Arg Met Thr Ile Cys Asn Met Ser Ile Glu Ala Gly 
    210                 215                 220                 

Ala Arg Ala Gly Leu Ile Ser Pro Asp Glu Thr Thr Phe Ala Tyr Leu 
225                 230                 235                 240 

Arg Gly Arg Lys Tyr Ala Pro Lys Gly Glu Glu Phe Asp Lys Ala Val 
                245                 250                 255     

Glu Arg Trp Arg Ala Leu Ala Ser Asp Glu Gly Ala Lys Tyr Asp Lys 
            260                 265                 270         

Thr Ile Glu Ile Asp Ala Ser Thr Ile Ala Pro Met Val Thr Trp Gly 
        275                 280                 285             

Thr Asn Pro Ala Met Ser Thr Ser Val Asp Gly Val Val Pro His Pro 
    290                 295                 300                 

Glu Gln Phe Glu Ser Lys Thr Glu Gln Asn Ala Val Arg Arg Ala Leu 
305                 310                 315                 320 

Glu Tyr Met Gly Leu Lys Pro Gly Thr Pro Ile Thr Asp Ile Pro Val 
                325                 330                 335     

Gln His Val Phe Ile Gly Ser Cys Thr Asn Ser Arg Leu Ser Asp Leu 
            340                 345                 350         

Arg Ala Ala Ala Ser Ile Val Lys Gly Lys Lys Val Ala Pro Gly Val 
        355                 360                 365             

Arg Ala Leu Val Val Pro Gly Ser Gln Gln Val Lys Lys Gln Ala Glu 
    370                 375                 380                 

Ala Glu Gly Leu Ala Gln Ile Phe Ile Asp Ala Gly Phe Glu Trp Arg 
385                 390                 395                 400 

Asp Ser Gly Cys Ser Ala Cys Leu Gly Met Asn Pro Asp Ile Ile Pro 
                405                 410                 415     

Glu Gly Glu His Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg 
            420                 425                 430         

Gln Gly Lys Gly Ala Arg Thr His Leu Val Ser Pro Val Met Ala Ala 
        435                 440                 445             

Ala Ala Ala Ile Tyr Gly His Phe Val Asp Val Arg Gln Leu Glu Ala 
    450                 455                 460                 

Glu Pro Val 
465         

<210>   243
<211>   467
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   243
Lys Thr Ile Ile Glu Lys Ile Trp Glu Asn His Val Val Tyr Arg Glu 
                5                   10                  15      

Glu Gly Lys Pro Asp Leu Leu Tyr Ile Asp Leu His Leu Val His Glu 
            20                  25                  30          

Val Thr Ser Pro Gln Ala Phe Glu Gly Leu Arg Gln Asn Gly Arg Lys 
        35                  40                  45              

Val Arg Arg Pro Asp Leu Thr Phe Ala Thr Met Asp His Asn Val Pro 
    50                  55                  60                  

Thr Val Asn Arg Phe Val Ile Thr Asp Glu Val Ala Arg Asn Gln Ile 
65                  70                  75                  80  

Ala Ala Leu Glu Arg Asn Cys Arg Glu Phe Gly Ile Pro Leu Ala Asp 
                85                  90                  95      

Leu His Ser Glu Glu Gln Gly Ile Val His Val Ile Gly Pro Glu Leu 
            100                 105                 110         

Gly Leu Thr Gln Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr 
        115                 120                 125             

Ser Thr His Gly Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser 
    130                 135                 140                 

Glu Val Glu His Val Leu Ala Thr Gln Thr Leu Trp Gln His Lys Pro 
145                 150                 155                 160 

Lys Thr Leu Gln Ile Arg Ile Asn Gly Gln Leu Gly Lys Gly Val Thr 
                165                 170                 175     

Ala Lys Asp Val Ile Leu Ala Ile Ile Gly Arg Tyr Gly Val Gly Val 
            180                 185                 190         

Gly Thr Gly Tyr Ile Ile Glu Phe Thr Gly Glu Ala Ile Arg Arg Met 
        195                 200                 205             

Ser Met Glu Glu Arg Met Thr Ile Cys Asn Met Ser Ile Glu Ala Gly 
    210                 215                 220                 

Ala Arg Ala Gly Leu Ile Ser Pro Asp Glu Thr Thr Phe Ala Tyr Leu 
225                 230                 235                 240 

Arg Gly Arg Lys Tyr Ala Pro Lys Gly Glu Glu Phe Asp Gln Ala Val 
                245                 250                 255     

Glu Arg Trp Arg Ala Leu Ala Ser Asp Glu Gly Ala Glu Tyr Asp Lys 
            260                 265                 270         

Thr Ile Glu Ile Asp Ala Ser Thr Ile Ala Pro Met Val Thr Trp Gly 
        275                 280                 285             

Thr Asn Pro Ser Met Ser Thr Ser Val Asp Gly Thr Val Pro Asp Pro 
    290                 295                 300                 

Glu Gln Phe Glu Ser Glu Thr Glu Arg Asn Ala Val Arg Arg Ala Leu 
305                 310                 315                 320 

Glu Tyr Met Gly Leu Lys Pro Gly Met Ser Ile Thr Glu Ile Pro Val 
                325                 330                 335     

Gln His Val Phe Ile Gly Ser Cys Thr Asn Ser Arg Ile Ser Asp Leu 
            340                 345                 350         

Arg Glu Ala Ala Lys Ile Val Lys Gly Gln Lys Val Ala Pro Gly Val 
        355                 360                 365             

Arg Ala Leu Val Val Pro Gly Ser Gln Gln Val Lys Lys Gln Ala Glu 
    370                 375                 380                 

Glu Glu Gly Leu Ala Gln Ile Phe Leu Asp Ala Gly Phe Glu Trp Arg 
385                 390                 395                 400 

Asp Ala Gly Cys Ser Ala Cys Leu Gly Met Asn Pro Asp Ile Ile Pro 
                405                 410                 415     

Glu Gly Glu His Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg 
            420                 425                 430         

Gln Gly Lys Gly Ala Arg Thr His Leu Val Ser Pro Ala Met Ala Ala 
        435                 440                 445             

Ala Ala Ala Ile Tyr Gly Arg Phe Val Asp Val Arg Gln Leu Glu Ala 
    450                 455                 460                 

Glu Pro Val 
465         

<210>   244
<211>   471
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   244
Met Gly Lys Ser Ile Val Glu Lys Ile Trp Asp Arg His Ile Val His 
                5                   10                  15      

Thr Glu Thr Asp Lys Pro Asp Leu Leu Tyr Ile Asp Leu His Leu Val 
            20                  25                  30          

His Glu Val Thr Ser Pro Gln Ala Phe Ser Gly Leu Arg Met Lys Asn 
        35                  40                  45              

Arg Lys Val Arg Arg Pro Asp Lys Thr Phe Ala Thr Met Asp His Asn 
    50                  55                  60                  

Val Pro Thr Ile Asn Arg Gly Gln Ile Asp Asp Pro Val Ala Lys Lys 
65                  70                  75                  80  

Gln Met Thr Thr Leu Glu Lys Asn Cys Arg Glu Phe Gly Val Pro Leu 
                85                  90                  95      

Ala Gly Met Asp Ser Pro Asp Gln Gly Ile Val His Val Ile Gly Pro 
            100                 105                 110         

Glu Leu Gly Leu Thr Arg Pro Gly Met Thr Ile Val Cys Gly Asp Ser 
        115                 120                 125             

His Thr Ser Thr His Gly Ala Phe Gly Ser Leu Ala Phe Gly Ile Gly 
    130                 135                 140                 

Thr Ser Glu Val Glu His Val Leu Ala Thr Gln Thr Leu Trp Gln Ser 
145                 150                 155                 160 

Arg Pro Lys Thr Leu Lys Leu Gln Ile Asp Gly Arg Leu Glu Ser Gly 
                165                 170                 175     

Val Thr Ala Lys Asp Val Ile Leu Tyr Ile Ile Ser Arg Phe Gly Ile 
            180                 185                 190         

Gly Phe Gly Thr Gly His Val Ile Glu Tyr Cys Gly Glu Ala Val Arg 
        195                 200                 205             

Ser Met Ser Met Glu Glu Arg Met Thr Ile Cys Asn Met Ser Ile Glu 
    210                 215                 220                 

Gly Gly Ala Arg Ala Gly Leu Val Ser Pro Asp Glu Thr Thr Phe Ser 
225                 230                 235                 240 

Tyr Ile Lys Gly Arg Lys Tyr Ala Pro Lys Asp Asn Glu Trp Asp Thr 
                245                 250                 255     

Ser Leu Ala His Trp Gln Ala Leu Ala Ser Asp Pro Asp Ala Asn Tyr 
            260                 265                 270         

Asp Lys Glu Ile Thr Leu Asp Ala Gly Glu Ile Pro Pro Met Val Ser 
        275                 280                 285             

Trp Gly Thr Asn Pro Ser Met Ala Ala Gly Val Asp Glu Arg Ile Pro 
    290                 295                 300                 

Ser Glu Ala Asp Cys Lys Thr Glu Thr Glu Arg Thr Ser Leu Glu Arg 
305                 310                 315                 320 

Ala Leu Arg Tyr Met Gly Leu Ser Glu Gly Gln Glu Ile Ser Asp Ile 
                325                 330                 335     

Ser Ile Gln His Val Phe Ile Gly Ser Cys Thr Asn Ser Arg Ile Glu 
            340                 345                 350         

Asp Leu Arg Gln Ala Ala Glu Phe Ala Ala Gly Lys Lys Val His Pro 
        355                 360                 365             

Gly Val Arg Ala Leu Val Val Pro Gly Ser Gln Ala Val Lys Glu Gln 
    370                 375                 380                 

Ala Glu Lys Glu Gly Leu His His Ile Phe Ile Glu Ser Gly Phe Glu 
385                 390                 395                 400 

Trp Arg Glu Ser Gly Cys Ser Met Cys Leu Ser Met Asn Asn Asp Ile 
                405                 410                 415     

Val Pro Pro Gly Glu His Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu 
            420                 425                 430         

Gly Arg Gln Gly Ser Gly Ala Arg Thr His Leu Val Ser Pro Leu Met 
        435                 440                 445             

Ala Ala Ala Ala Ala Val Asn Gly Lys Phe Val Asp Val Arg Lys Thr 
    450                 455                 460                 

Leu Met Glu Glu Ser Ile Thr 
465                 470     

<210>   245
<211>   473
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   245
Met Ser Gly Arg Thr Leu Leu Asp Lys Ile Trp Glu Arg His Val Val 
                5                   10                  15      

Arg Arg Glu Pro Gly Lys Pro Asp Leu Leu Tyr Ile Asp Leu His Leu 
            20                  25                  30          

Val His Glu Val Thr Ser Pro Gln Ala Phe Glu Gly Leu Arg Met Ala 
        35                  40                  45              

Gly Arg Arg Val Arg Arg Pro Asp Leu Thr Ile Ala Thr Met Asp His 
    50                  55                  60                  

Asn Val Pro Thr Thr Asp Arg Ser Leu Pro Leu Thr Asp Glu Ile Ala 
65                  70                  75                  80  

Ala Arg Gln Met Ala Ala Leu Glu Arg Asn Cys Ser Glu Phe Gly Val 
                85                  90                  95      

Arg Leu Phe Asp Leu Tyr Ser Pro Phe Gln Gly Ile Val His Val Ile 
            100                 105                 110         

Gly Pro Glu Leu Gly Leu Thr Gln Pro Gly Leu Thr Ile Val Cys Gly 
        115                 120                 125             

Asp Ser His Thr Ala Thr His Gly Ala Phe Gly Ala Leu Ala Phe Gly 
    130                 135                 140                 

Ile Gly Thr Ser Glu Val Glu His Val Leu Ala Thr Gln Cys Leu Trp 
145                 150                 155                 160 

Gln His Lys Pro Lys Val Met Glu Ile Arg Val Asn Gly Lys Leu Pro 
                165                 170                 175     

Pro Gly Thr Thr Ala Lys Asp Leu Ile Leu Gly Ile Ile Gly Gln Ile 
            180                 185                 190         

Gly Thr Asp Gly Ala Thr Gly Tyr Val Ile Glu Tyr Thr Gly Glu Ala 
        195                 200                 205             

Ile Arg Ser Leu Ser Met Glu Gly Arg Met Thr Val Cys Asn Met Ser 
    210                 215                 220                 

Ile Glu Ala Gly Ala Arg Ala Gly Met Ile Ala Pro Asp Glu Thr Thr 
225                 230                 235                 240 

Phe Ala Tyr Leu Lys Gly Arg Pro His Ala Pro Gln Gly Glu Leu Trp 
                245                 250                 255     

Glu Ala Ala Val Ala Asp Trp Arg Thr Leu Ala Ser Asp Pro Asp Ala 
            260                 265                 270         

Val Tyr Asp Arg Val Val Glu Phe Asp Ala Gly Gln Leu Ala Pro Val 
        275                 280                 285             

Val Ser Trp Gly Thr Asn Pro Gly Gln Val Val Pro Val Thr Gly Arg 
    290                 295                 300                 

Ile Pro Asp Pro Arg Asp Phe Ala Asp Pro Ala Gln Arg Lys Ala Ala 
305                 310                 315                 320 

Glu Ala Ala Leu Ala Tyr Met Asp Leu Glu Pro Gly Thr Pro Ile Gln 
                325                 330                 335     

Asp Ile Arg Ile Asp Arg Val Phe Ile Gly Ser Cys Thr Asn Gly Arg 
            340                 345                 350         

Ile Glu Asp Leu Arg Ala Ala Ala Ala Val Val Lys Gly Arg Lys Val 
        355                 360                 365             

Ala Pro Gly Val Arg Ala Met Val Val Pro Gly Ser Gly Gln Val Lys 
    370                 375                 380                 

Ala Gln Ala Glu Ala Glu Gly Leu Asp Gln Ile Phe Arg Glu Ala Gly 
385                 390                 395                 400 

Phe Glu Trp Arg Glu Ala Gly Cys Ser Met Cys Leu Gly Met Asn Pro 
                405                 410                 415     

Asp Ile Leu Ala Pro Gly Glu Arg Cys Ala Ser Thr Ser Asn Arg Asn 
            420                 425                 430         

Phe Glu Gly Arg Gln Gly Lys Gly Gly Arg Thr His Leu Val Ser Pro 
        435                 440                 445             

Ala Met Ala Ala Ala Ala Ala Ile Ala Gly His Phe Val Asp Val Arg 
    450                 455                 460                 

Glu Leu Leu Ala Glu Gly Gly Ala Ala 
465                 470             

<210>   246
<211>   481
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   246
Met Arg Arg Arg Glu Lys Glu Ala Arg Leu Met Gly Arg Thr Leu Phe 
                5                   10                  15      

Glu Lys Val Trp Asp Ala His Val Val Lys Glu Leu Pro Asp Gly Gln 
            20                  25                  30          

Thr Leu Leu Tyr Ile Asp Leu His Leu Val His Glu Val Thr Ser Pro 
        35                  40                  45              

Gln Ala Phe Ala Gly Leu Arg Phe Ala Gly Arg Lys Val Arg Arg Pro 
    50                  55                  60                  

Glu Leu Thr Phe Ala Thr Met Asp His Asn Val Pro Thr Val Asn Pro 
65                  70                  75                  80  

Lys Asp Val Arg Asp Ala Ile Ala Arg Lys Gln Ile Glu Thr Leu Glu 
                85                  90                  95      

Gln Asn Cys Arg Glu Phe Gly Val Gln Leu Ala Gly Leu Asp Ser Pro 
            100                 105                 110         

Phe Gln Gly Ile Val His Val Ile Gly Pro Glu Leu Gly Leu Thr Met 
        115                 120                 125             

Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr Ser Thr His Gly 
    130                 135                 140                 

Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser Glu Val Glu His 
145                 150                 155                 160 

Val Leu Ala Thr Gln Cys Leu Trp Gln Ser Arg Pro Lys Thr Met Arg 
                165                 170                 175     

Ile Gln Leu Asn Gly Thr Leu Gln Pro Gly Val Thr Ala Lys Asp Val 
            180                 185                 190         

Ile Leu Gly Leu Ile Ala Lys Tyr Gly Val Asn Phe Gly Thr Gly His 
        195                 200                 205             

Val Val Glu Tyr Ala Gly Ser Leu Ile Pro Glu Leu Ser Met Glu Gln 
    210                 215                 220                 

Arg Met Thr Ile Cys Asn Met Ser Ile Glu Phe Gly Ala Arg Ala Gly 
225                 230                 235                 240 

Met Met Ala Pro Asp Glu Thr Thr Ile Ala Tyr Val Gln Gly Arg Arg 
                245                 250                 255     

Tyr Ala Pro Lys Gly Ala Asp Trp Glu Ala Cys Val Ala Ala Trp Arg 
            260                 265                 270         

Glu Leu Lys Ser Asp Pro Asp Ala Val Phe Asp Val Asp Val Val Phe 
        275                 280                 285             

Asp Val Asn Asp Leu Glu Pro Gln Val Thr Trp Gly Thr Asn Pro Gly 
    290                 295                 300                 

Gln Gly Thr Gly Ile Ser Gly Val Val Pro Asp Pro Arg Asp Ala Lys 
305                 310                 315                 320 

Ser Glu Glu Glu Ala Leu Ala Ile Arg Gln Ala Leu Glu Tyr Met Asp 
                325                 330                 335     

Leu Lys Pro Gly Thr Lys Ile Ser Glu Ile Pro Ile Gln His Val Phe 
            340                 345                 350         

Ile Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu Arg Leu Ala Ala 
        355                 360                 365             

Ser Ile Val Lys Gly Arg Arg Val Ala Asp Gly Val Arg Ala Val Val 
    370                 375                 380                 

Val Pro Gly Ser Lys Gln Val Lys Gln Gln Ala Glu Ala Glu Gly Leu 
385                 390                 395                 400 

His Glu Ile Phe Leu Glu Ala Gly Phe Glu Trp Arg Glu Pro Gly Cys 
                405                 410                 415     

Ser Ala Cys Leu Gly Met Asn Pro Asp Ile Ile Pro Ala Gly Glu Arg 
            420                 425                 430         

Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg Gln Gly Lys Gly 
        435                 440                 445             

Ala Arg Thr His Leu Val Ser Pro Ala Met Ala Ala Ala Ala Ala Ile 
    450                 455                 460                 

Ala Gly His Phe Val Asp Val Arg Glu Leu Thr Ser Glu Gly Val Thr 
465                 470                 475                 480 

Ala 
    

<210>   247
<211>   481
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   247
Met Arg Arg Arg Glu Lys Glu Ala Arg Leu Met Gly Arg Thr Leu Phe 
                5                   10                  15      

Glu Lys Val Trp Asp Ala His Ile Val Lys Glu Leu Pro Asp Gly Gln 
            20                  25                  30          

Thr Leu Leu Tyr Ile Asp Leu His Leu Val His Glu Val Thr Ser Pro 
        35                  40                  45              

Gln Ala Phe Ala Gly Leu Arg Phe Ala Gly Arg Lys Val Arg Arg Pro 
    50                  55                  60                  

Glu Leu Thr Phe Ala Thr Met Asp His Asn Val Pro Thr Val Asn Pro 
65                  70                  75                  80  

Lys Asp Val Arg Asp Ala Ile Ala Arg Lys Gln Ile Glu Thr Leu Glu 
                85                  90                  95      

Gln Asn Cys Arg Glu Phe Gly Val Gln Leu Ala Gly Leu Asp Ser Pro 
            100                 105                 110         

Phe Gln Gly Ile Val His Val Ile Gly Pro Glu Leu Gly Leu Thr Met 
        115                 120                 125             

Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr Ser Thr His Gly 
    130                 135                 140                 

Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser Glu Val Glu His 
145                 150                 155                 160 

Val Leu Ala Thr Gln Cys Leu Trp Gln Ser Arg Pro Lys Thr Met Arg 
                165                 170                 175     

Ile Gln Leu Asn Gly Thr Leu Gln Pro Gly Val Thr Ala Lys Asp Val 
            180                 185                 190         

Ile Leu Gly Leu Ile Ala Lys Tyr Gly Val Asn Phe Gly Thr Gly His 
        195                 200                 205             

Val Val Glu Tyr Ala Gly Ser Leu Ile Pro Glu Leu Ser Met Glu Gln 
    210                 215                 220                 

Arg Met Thr Ile Cys Asn Met Ser Ile Glu Phe Gly Ala Arg Ala Gly 
225                 230                 235                 240 

Met Met Ala Pro Asp Glu Thr Thr Ile Ala Tyr Val Gln Gly Arg Arg 
                245                 250                 255     

Tyr Ala Pro Lys Gly Ala Asp Trp Glu Ala Cys Val Ala Ala Trp Arg 
            260                 265                 270         

Glu Leu Lys Ser Asp Pro Asp Ala Val Phe Asp Val Asp Val Val Phe 
        275                 280                 285             

Asp Val Asn Asp Leu Glu Pro Gln Val Thr Trp Gly Thr Asn Pro Gly 
    290                 295                 300                 

Gln Gly Thr Gly Ile Ser Gly Val Val Pro Asp Pro Lys Asp Ala Lys 
305                 310                 315                 320 

Ser Glu Glu Glu Ala Leu Ala Ile Arg Gln Ala Leu Glu Tyr Met Asp 
                325                 330                 335     

Leu Lys Pro Gly Thr Lys Ile Ser Glu Ile Pro Ile Gln His Val Phe 
            340                 345                 350         

Ile Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu Arg Leu Ala Ala 
        355                 360                 365             

Ser Ile Val Lys Gly Arg Arg Val Ala Asp Gly Val Arg Ala Val Val 
    370                 375                 380                 

Val Pro Gly Ser Lys Gln Val Lys Gln Gln Ala Glu Ala Glu Gly Leu 
385                 390                 395                 400 

His Glu Ile Phe Leu Glu Ala Gly Phe Glu Trp Arg Glu Pro Gly Cys 
                405                 410                 415     

Ser Ala Cys Leu Gly Met Asn Pro Asp Ile Ile Pro Ala Gly Glu Arg 
            420                 425                 430         

Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg Gln Gly Lys Gly 
        435                 440                 445             

Ala Arg Thr His Leu Val Ser Pro Ala Met Ala Ala Ala Ala Ala Ile 
    450                 455                 460                 

Ala Gly His Phe Val Asp Val Arg Glu Leu Thr Ser Glu Gly Val Thr 
465                 470                 475                 480 

Ala 
    

<210>   248
<211>   481
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   248
Met Arg Arg Arg Glu Lys Glu Ala Arg Leu Met Gly Arg Thr Leu Phe 
                5                   10                  15      

Glu Lys Val Trp Asp Ala His Val Val Lys Glu Leu Pro Asp Gly Gln 
            20                  25                  30          

Thr Leu Leu Tyr Ile Asp Leu His Leu Val His Glu Val Thr Ser Pro 
        35                  40                  45              

Gln Ala Phe Ala Gly Leu Arg Phe Ala Gly Arg Lys Val Arg Arg Pro 
    50                  55                  60                  

Glu Leu Thr Phe Ala Thr Met Asp His Asn Val Pro Thr Val Asn Pro 
65                  70                  75                  80  

Lys Asp Val Arg Asp Ala Ile Ala Arg Lys Gln Ile Glu Thr Leu Glu 
                85                  90                  95      

Gln Asn Cys Arg Glu Phe Gly Val Gln Leu Ala Gly Leu Asp Ser Pro 
            100                 105                 110         

Phe Gln Gly Ile Val His Val Ile Gly Pro Glu Leu Gly Leu Thr Met 
        115                 120                 125             

Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr Ser Thr His Gly 
    130                 135                 140                 

Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser Glu Val Glu His 
145                 150                 155                 160 

Val Leu Ala Thr Gln Cys Leu Trp Gln Ser Arg Pro Lys Thr Met Arg 
                165                 170                 175     

Ile Gln Leu Asn Gly Thr Leu Gln Pro Gly Val Thr Ala Lys Asp Val 
            180                 185                 190         

Ile Leu Gly Leu Ile Ala Lys Tyr Gly Val Asn Phe Gly Thr Gly His 
        195                 200                 205             

Val Val Glu Tyr Ala Gly Ser Leu Ile Pro Glu Leu Ser Met Glu Gln 
    210                 215                 220                 

Arg Met Thr Ile Cys Asn Met Ser Ile Glu Phe Gly Ala Arg Ala Gly 
225                 230                 235                 240 

Met Met Ala Pro Asp Glu Thr Thr Ile Ala Tyr Val Gln Gly Arg Arg 
                245                 250                 255     

Tyr Ala Pro Lys Gly Ala Asp Trp Glu Ala Cys Val Ala Ala Trp Arg 
            260                 265                 270         

Glu Leu Lys Ser Asp Pro Asp Ala Val Phe Asp Val Asp Val Val Phe 
        275                 280                 285             

Asp Val Asn Asp Leu Glu Pro Gln Val Thr Trp Gly Thr Asn Pro Gly 
    290                 295                 300                 

Gln Gly Thr Gly Ile Ser Gly Val Val Pro Asp Pro Lys Asp Ala Lys 
305                 310                 315                 320 

Ser Glu Glu Glu Ala Leu Ala Ile Arg Gln Ala Leu Glu Tyr Met Asp 
                325                 330                 335     

Leu Lys Pro Gly Thr Lys Ile Ser Glu Ile Pro Ile Gln His Val Phe 
            340                 345                 350         

Ile Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu Arg Leu Ala Ala 
        355                 360                 365             

Ser Ile Val Lys Gly Arg Arg Val Ala Asp Gly Val Arg Ala Val Val 
    370                 375                 380                 

Val Pro Gly Ser Arg Gln Val Lys Gln Gln Ala Glu Ala Glu Gly Leu 
385                 390                 395                 400 

His Glu Ile Phe Leu Glu Ala Gly Phe Glu Trp Arg Glu Pro Gly Cys 
                405                 410                 415     

Ser Ala Cys Leu Gly Met Asn Pro Asp Ile Ile Pro Ala Gly Glu Arg 
            420                 425                 430         

Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg Gln Gly Lys Gly 
        435                 440                 445             

Ala Arg Thr His Leu Val Ser Pro Ala Met Ala Ala Ala Ala Ala Ile 
    450                 455                 460                 

Ala Gly His Phe Val Asp Val Arg Glu Leu Thr Ser Glu Gly Val Thr 
465                 470                 475                 480 

Ala 
    

<210>   249
<211>   481
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   249
Met Arg Arg Arg Glu Lys Glu Ala Arg Leu Met Gly Arg Thr Leu Phe 
                5                   10                  15      

Glu Lys Val Trp Asp Ala His Val Val Arg Glu Leu Pro Asp Gly Gln 
            20                  25                  30          

Thr Leu Leu Tyr Ile Asp Leu His Leu Val His Glu Val Thr Ser Pro 
        35                  40                  45              

Gln Ala Phe Ala Gly Leu Arg Phe Ala Gly Arg Lys Val Arg Arg Pro 
    50                  55                  60                  

Glu Leu Thr Phe Ala Thr Met Asp His Asn Val Pro Thr Val Asn Pro 
65                  70                  75                  80  

Lys Asp Val Arg Asp Ala Ile Ala Arg Lys Gln Ile Glu Thr Leu Glu 
                85                  90                  95      

Gln Asn Cys Arg Glu Phe Gly Val Gln Leu Ala Gly Leu Asp Ser Pro 
            100                 105                 110         

Phe Gln Gly Ile Val His Val Ile Gly Pro Glu Leu Gly Leu Thr Met 
        115                 120                 125             

Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr Ser Thr His Gly 
    130                 135                 140                 

Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser Glu Val Glu His 
145                 150                 155                 160 

Val Leu Ala Thr Gln Cys Leu Trp Gln Ser Arg Pro Lys Thr Met Arg 
                165                 170                 175     

Ile Gln Leu Asn Gly Thr Leu Gln Pro Gly Val Thr Ala Lys Asp Val 
            180                 185                 190         

Ile Leu Gly Leu Ile Ala Lys Tyr Gly Val Asn Phe Gly Thr Gly His 
        195                 200                 205             

Val Val Glu Tyr Ala Gly Ser Leu Ile Pro Glu Leu Ser Met Glu Gln 
    210                 215                 220                 

Arg Met Thr Ile Cys Asn Met Ser Ile Glu Phe Gly Ala Arg Ala Gly 
225                 230                 235                 240 

Met Met Ala Pro Asp Glu Thr Thr Ile Ala Tyr Val Gln Gly Arg Arg 
                245                 250                 255     

Tyr Ala Pro Lys Gly Ala Asp Trp Glu Ala Cys Val Ala Ala Trp Arg 
            260                 265                 270         

Glu Leu Lys Ser Asp Pro Asp Ala Val Phe Asp Val Asp Val Val Phe 
        275                 280                 285             

Asp Val Asn Asp Leu Glu Pro Gln Val Thr Trp Gly Thr Asn Pro Gly 
    290                 295                 300                 

Gln Gly Thr Gly Ile Ser Gly Val Val Pro Asp Pro Lys Asp Ala Lys 
305                 310                 315                 320 

Ser Glu Glu Glu Ala Leu Ala Ile Arg Gln Ala Leu Glu Tyr Met Asp 
                325                 330                 335     

Leu Lys Pro Gly Thr Lys Ile Ser Glu Ile Pro Ile Gln His Val Phe 
            340                 345                 350         

Ile Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu Arg Leu Ala Ala 
        355                 360                 365             

Ser Ile Val Lys Gly Arg Arg Val Ala Asp Gly Val Arg Ala Val Val 
    370                 375                 380                 

Val Pro Gly Ser Lys Gln Val Lys Gln Gln Ala Glu Ala Glu Gly Leu 
385                 390                 395                 400 

His Glu Ile Phe Leu Glu Ala Gly Phe Glu Trp Arg Glu Pro Gly Cys 
                405                 410                 415     

Ser Ala Cys Leu Gly Met Asn Pro Asp Ile Ile Pro Ala Gly Glu Arg 
            420                 425                 430         

Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg Gln Gly Lys Gly 
        435                 440                 445             

Ala Arg Thr His Leu Val Ser Pro Ala Met Ala Ala Ala Ala Ala Ile 
    450                 455                 460                 

Ala Gly His Phe Val Asp Val Arg Glu Leu Thr Ser Glu Gly Val Thr 
465                 470                 475                 480 

Ala 
    

<210>   250
<211>   481
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   250
Met Arg Arg Arg Glu Lys Glu Ala Arg Leu Met Gly Arg Thr Leu Phe 
                5                   10                  15      

Glu Lys Val Trp Asp Ala His Val Val Lys Glu Leu Pro Asp Gly Gln 
            20                  25                  30          

Thr Leu Leu Tyr Ile Asp Leu His Leu Val His Glu Val Thr Ser Pro 
        35                  40                  45              

Gln Ala Phe Ala Gly Leu Arg Phe Ala Gly Arg Lys Val Arg Arg Pro 
    50                  55                  60                  

Glu Leu Thr Phe Ala Thr Met Asp His Asn Val Pro Thr Val Asn Pro 
65                  70                  75                  80  

Lys Asp Val Arg Asp Ala Ile Ala Arg Lys Gln Ile Glu Thr Leu Glu 
                85                  90                  95      

Gln Asn Cys Arg Glu Phe Gly Val Gln Leu Ala Gly Leu Asp Ser Pro 
            100                 105                 110         

Phe Gln Gly Ile Val His Val Ile Gly Pro Glu Leu Gly Leu Thr Met 
        115                 120                 125             

Pro Gly Lys Thr Ile Val Cys Gly Asp Ser His Thr Ser Thr His Gly 
    130                 135                 140                 

Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser Glu Val Glu His 
145                 150                 155                 160 

Val Leu Ala Thr Gln Cys Leu Trp Gln Ser Arg Pro Lys Thr Met Arg 
                165                 170                 175     

Ile Gln Leu Asn Gly Thr Leu Gln Pro Gly Val Thr Ala Lys Asp Val 
            180                 185                 190         

Ile Leu Gly Leu Ile Ala Lys Tyr Gly Val Asn Phe Gly Thr Gly His 
        195                 200                 205             

Val Val Glu Tyr Ala Gly Ser Leu Ile Pro Glu Leu Ser Met Glu Gln 
    210                 215                 220                 

Arg Met Thr Ile Cys Asn Met Ser Ile Glu Phe Gly Ala Arg Ala Gly 
225                 230                 235                 240 

Met Met Ala Pro Asp Glu Thr Thr Ile Ala Tyr Val Gln Gly Arg Arg 
                245                 250                 255     

Tyr Ala Pro Lys Gly Ala Asp Trp Glu Ala Cys Val Ala Ala Trp Arg 
            260                 265                 270         

Glu Leu Lys Ser Asp Pro Asp Ala Val Phe Asp Val Asp Val Val Phe 
        275                 280                 285             

Asp Val Asn Asp Leu Glu Pro Gln Val Thr Trp Gly Thr Asn Pro Gly 
    290                 295                 300                 

Gln Gly Thr Gly Ile Ser Gly Val Val Pro Asp Pro Lys Asp Ala Lys 
305                 310                 315                 320 

Ser Asp Glu Glu Ala Leu Ala Ile Arg Gln Ala Leu Glu Tyr Met Asp 
                325                 330                 335     

Leu Lys Pro Gly Thr Lys Ile Ser Glu Ile Pro Ile Gln His Val Phe 
            340                 345                 350         

Ile Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp Leu Arg Leu Ala Ala 
        355                 360                 365             

Ser Ile Val Lys Gly Arg Arg Val Ala Asp Gly Val Arg Ala Val Val 
    370                 375                 380                 

Val Pro Gly Ser Lys Gln Val Lys Gln Gln Ala Glu Ala Glu Gly Leu 
385                 390                 395                 400 

His Glu Ile Phe Leu Glu Ala Gly Phe Glu Trp Arg Glu Pro Gly Cys 
                405                 410                 415     

Ser Ala Cys Leu Gly Met Asn Pro Asp Ile Ile Pro Ala Gly Glu Arg 
            420                 425                 430         

Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly Arg Gln Gly Lys Gly 
        435                 440                 445             

Ala Arg Thr His Leu Val Ser Pro Ala Met Ala Ala Ala Ala Ala Ile 
    450                 455                 460                 

Ala Gly His Phe Val Asp Val Arg Glu Leu Thr Ser Glu Gly Val Thr 
465                 470                 475                 480 

Ala 
    

<210>   251
<211>   1446
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   251
ttgcgaagac gtgaaaagga ggctcggttg atggggagga ccctgttcga aaaagtctgg       60

gacgcgcacg tggtcaagga actgccggat ggacagacgc ttctctacat tgacttgcac      120

ctcgtccacg aggtgacgtc gcctcaggcg tttgccggac ttcgtttcgc ggggcgcaag      180

gttcgccggc ccgagctgac gtttgcgacc atggatcaca acgtgccgac ggtcaatccg      240

aaggatgtcc gggacgccat tgcgcgcaag cagatcgaga cgctggagca gaactgccgc      300

gagttcggcg tccaactggc ggggctcgac agccccttcc agggcattgt gcatgtcatc      360

ggcccggagc ttgggctgac catgccgggg aagacgattg tctgcggcga cagccacacg      420

tcgacgcacg gcgcgttcgg cgcgctcgcc tttggcatcg gcacgagcga ggtggaacac      480

gttctcgcca cgcagtgcct ctggcagagc cgaccgaaga ccatgcgcat tcagctgaat      540

ggcacgcttc aaccgggcgt caccgccaag gacgtgatct tgggcctgat tgcgaaatac      600

ggcgtgaatt ttggcacggg ccacgtcgtg gagtacgcgg gcagcctgat cccagagctc      660

agcatggagc agcggatgac catctgcaac atgtccatcg agttcggcgc ccgggcgggc      720

atgatggcgc cggacgagac gaccatcgcc tacgtccagg gccggcgcta tgcgccgaag      780

ggcgcggatt gggaggcgtg cgtcgccgca tggcgcgaac tgaagtccga tcccgacgcc      840

gtcttcgacg tcgacgtggt cttcgatgtg aatgacctcg agccgcaggt gacgtggggc      900

accaatccgg ggcaggggac cggcatcagc ggcgtcgtgc cggatccgcg tgacgcgaag      960

tccgaggagg aggcgctggc cattcgacag gcgcttgagt acatggacct gaagccggga     1020

accaaaatct ccgagatccc catccagcac gtgttcatcg gatcgtgcac caacgcccgc     1080

atcgaggatc tgcgcttggc cgcgagcatc gtcaagggcc ggcgcgtcgc ggatggcgtg     1140

cgcgcggtgg tcgtgccggg atcgaaacag gtgaagcagc aggcggaggc cgaggggctt     1200

cacgagatct tcctcgaagc gggcttcgag tggcgcgagc ccggctgcag cgcgtgtctc     1260

ggcatgaatc ccgacatcat cccggctggg gagcggtgcg catcgacgtc caaccgcaac     1320

ttcgaaggcc ggcagggcaa aggggcccgc acgcacctcg tcagcccggc catggcggcc     1380

gccgcggcca tcgcggggca cttcgtcgac gtgcgcgaac tgacctcgga aggagtgacg     1440

gcgtga                                                                1446


<210>   252
<211>   1446
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   252
ttgcgaagac gtgaaaagga ggctcggttg atggggagga ccctgttcga aaaagtctgg       60

gacgcgcaca ttgtcaagga actgccggat ggacagacgc ttctctacat tgacttgcac      120

ctcgtccacg aggtgacgtc gcctcaggcg tttgccggac ttcgtttcgc ggggcgcaag      180

gttcgccggc ccgagctgac gtttgcgacc atggatcaca acgtgccgac ggtcaatccg      240

aaggatgtcc gggacgccat tgcgcgcaag cagatcgaga cgctggagca gaactgccgc      300

gagttcggcg tccaactggc ggggctcgac agccccttcc agggcattgt gcatgtcatc      360

ggcccggagc ttgggctgac catgccgggg aagacgattg tctgcggcga cagccacacg      420

tcgacgcacg gcgcgttcgg cgcgctcgcc tttggcatcg gcacgagcga ggtggaacac      480

gttctcgcca cgcagtgcct ctggcagagc cgaccgaaga ccatgcgcat tcagctgaat      540

ggcacgcttc aaccgggcgt caccgccaag gacgtgatct tgggcctgat tgcgaaatac      600

ggcgtgaatt ttggcacggg ccacgtcgtg gagtacgcgg gcagcctgat cccagagctc      660

agcatggagc agcggatgac catctgcaac atgtccatcg agttcggcgc ccgggcgggc      720

atgatggcgc cggacgagac gaccatcgcc tacgtccagg gccggcgcta tgcgccgaag      780

ggcgcggatt gggaggcgtg cgtcgccgca tggcgcgaac tgaagtccga tcccgacgcc      840

gtcttcgacg tcgacgtggt cttcgatgtg aatgacctcg agccgcaggt gacgtggggc      900

accaatccgg ggcaggggac cggcatcagc ggcgtcgtgc cggatccgaa ggacgcgaag      960

tccgaggagg aggcgctggc cattcgacag gcgcttgagt acatggacct gaagccggga     1020

accaaaatct ccgagatccc catccagcac gtgttcatcg gatcgtgcac caacgcccgc     1080

atcgaggatc tgcgcttggc cgcgagcatc gtcaagggcc ggcgcgtcgc ggatggcgtg     1140

cgcgcggtgg tcgtgccggg atcgaaacag gtgaagcagc aggcggaggc cgaggggctt     1200

cacgagatct tcctcgaagc gggcttcgag tggcgcgagc ccggctgcag cgcgtgtctc     1260

ggcatgaatc ccgacatcat cccggctggg gagcggtgcg catcgacgtc caaccgcaac     1320

ttcgaaggcc ggcagggcaa aggggcccgc acgcacctcg tcagcccggc catggcggcc     1380

gccgcggcca tcgcggggca cttcgtcgac gtgcgcgaac tgacctcgga aggagtgacg     1440

gcgtga                                                                1446


<210>   253
<211>   1446
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   253
ttgcgaagac gtgaaaagga ggctcggttg atggggagga ccctgttcga aaaagtctgg       60

gacgcgcacg tggtcaagga actgccggat ggacagacgc ttctctacat tgacttgcac      120

ctcgtccacg aggtgacgtc gcctcaggcg tttgccggac ttcgtttcgc ggggcgcaag      180

gttcgccggc ccgagctgac gtttgcgacc atggatcaca acgtgccgac ggtcaatccg      240

aaggatgtcc gggacgccat tgcgcgcaag cagatcgaga cgctggagca gaactgccgc      300

gagttcggcg tccaactggc ggggctcgac agccccttcc agggcattgt gcatgtcatc      360

ggcccggagc ttgggctgac catgccgggg aagacgattg tctgcggcga cagccacacg      420

tcgacgcacg gcgcgttcgg cgcgctcgcc tttggcatcg gcacgagcga ggtggaacac      480

gttctcgcca cgcagtgcct ctggcagagc cgaccgaaga ccatgcgcat tcagctgaat      540

ggcacgcttc aaccgggcgt caccgccaag gacgtgatct tgggcctgat tgcgaaatac      600

ggcgtgaatt ttggcacggg ccacgtcgtg gagtacgcgg gcagcctgat cccagagctc      660

agcatggagc agcggatgac catctgcaac atgtccatcg agttcggcgc ccgggcgggc      720

atgatggcgc cggacgagac gaccatcgcc tacgtccagg gccggcgcta tgcgccgaag      780

ggcgcggatt gggaggcgtg cgtcgccgca tggcgcgaac tgaagtccga tcccgacgcc      840

gtcttcgacg tcgacgtggt cttcgatgtg aatgacctcg agccgcaggt gacgtggggc      900

accaatccgg ggcaggggac cggcatcagc ggcgtcgtgc cggatccgaa ggacgcgaag      960

tccgaggagg aggcgctggc cattcgacag gcgcttgagt acatggacct gaagccggga     1020

accaaaatct ccgagatccc catccagcac gtgttcatcg gatcgtgcac caacgcccgc     1080

atcgaggatc tgcgcttggc cgcgagcatc gtcaagggcc ggcgcgtcgc ggatggcgtg     1140

cgcgcggtgg tcgtgccggg atcgcgtcag gtgaagcagc aggcggaggc cgaggggctt     1200

cacgagatct tcctcgaagc gggcttcgag tggcgcgagc ccggctgcag cgcgtgtctc     1260

ggcatgaatc ccgacatcat cccggctggg gagcggtgcg catcgacgtc caaccgcaac     1320

ttcgaaggcc ggcagggcaa aggggcccgc acgcacctcg tcagcccggc catggcggcc     1380

gccgcggcca tcgcggggca cttcgtcgac gtgcgcgaac tgacctcgga aggagtgacg     1440

gcgtga                                                                1446


<210>   254
<211>   1446
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   254
ttgcgaagac gtgaaaagga ggctcggttg atggggagga ccctgttcga aaaagtctgg       60

gacgcgcacg tggtccgtga actgccggat ggacagacgc ttctctacat tgacttgcac      120

ctcgtccacg aggtgacgtc gcctcaggcg tttgccggac ttcgtttcgc ggggcgcaag      180

gttcgccggc ccgagctgac gtttgcgacc atggatcaca acgtgccgac ggtcaatccg      240

aaggatgtcc gggacgccat tgcgcgcaag cagatcgaga cgctggagca gaactgccgc      300

gagttcggcg tccaactggc ggggctcgac agccccttcc agggcattgt gcatgtcatc      360

ggcccggagc ttgggctgac catgccgggg aagacgattg tctgcggcga cagccacacg      420

tcgacgcacg gcgcgttcgg cgcgctcgcc tttggcatcg gcacgagcga ggtggaacac      480

gttctcgcca cgcagtgcct ctggcagagc cgaccgaaga ccatgcgcat tcagctgaat      540

ggcacgcttc aaccgggcgt caccgccaag gacgtgatct tgggcctgat tgcgaaatac      600

ggcgtgaatt ttggcacggg ccacgtcgtg gagtacgcgg gcagcctgat cccagagctc      660

agcatggagc agcggatgac catctgcaac atgtccatcg agttcggcgc ccgggcgggc      720

atgatggcgc cggacgagac gaccatcgcc tacgtccagg gccggcgcta tgcgccgaag      780

ggcgcggatt gggaggcgtg cgtcgccgca tggcgcgaac tgaagtccga tcccgacgcc      840

gtcttcgacg tcgacgtggt cttcgatgtg aatgacctcg agccgcaggt gacgtggggc      900

accaatccgg ggcaggggac cggcatcagc ggcgtcgtgc cggatccgaa ggacgcgaag      960

tccgaggagg aggcgctggc cattcgacag gcgcttgagt acatggacct gaagccggga     1020

accaaaatct ccgagatccc catccagcac gtgttcatcg gatcgtgcac caacgcccgc     1080

atcgaggatc tgcgcttggc cgcgagcatc gtcaagggcc ggcgcgtcgc ggatggcgtg     1140

cgcgcggtgg tcgtgccggg atcgaaacag gtgaagcagc aggcggaggc cgaggggctt     1200

cacgagatct tcctcgaagc gggcttcgag tggcgcgagc ccggctgcag cgcgtgtctc     1260

ggcatgaatc ccgacatcat cccggctggg gagcggtgcg catcgacgtc caaccgcaac     1320

ttcgaaggcc ggcagggcaa aggggcccgc acgcacctcg tcagcccggc catggcggcc     1380

gccgcggcca tcgcggggca cttcgtcgac gtgcgcgaac tgacctcgga aggagtgacg     1440

gcgtga                                                                1446


<210>   255
<211>   1446
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   255
ttgcgaagac gtgaaaagga ggctcggttg atggggagga ccctgttcga aaaagtctgg       60

gacgcgcacg tggtcaagga actgccggat ggacagacgc ttctctacat tgacttgcac      120

ctcgtccacg aggtgacgtc gcctcaggcg tttgccggac ttcgtttcgc ggggcgcaag      180

gttcgccggc ccgagctgac gtttgcgacc atggatcaca acgtgccgac ggtcaatccg      240

aaggatgtcc gggacgccat tgcgcgcaag cagatcgaga cgctggagca gaactgccgc      300

gagttcggcg tccaactggc ggggctcgac agccccttcc agggcattgt gcatgtcatc      360

ggcccggagc ttgggctgac catgccgggg aagacgattg tctgcggcga cagccacacg      420

tcgacgcacg gcgcgttcgg cgcgctcgcc tttggcatcg gcacgagcga ggtggaacac      480

gttctcgcca cgcagtgcct ctggcagagc cgaccgaaga ccatgcgcat tcagctgaat      540

ggcacgcttc aaccgggcgt caccgccaag gacgtgatct tgggcctgat tgcgaaatac      600

ggcgtgaatt ttggcacggg ccacgtcgtg gagtacgcgg gcagcctgat cccagagctc      660

agcatggagc agcggatgac catctgcaac atgtccatcg agttcggcgc ccgggcgggc      720

atgatggcgc cggacgagac gaccatcgcc tacgtccagg gccggcgcta tgcgccgaag      780

ggcgcggatt gggaggcgtg cgtcgccgca tggcgcgaac tgaagtccga tcccgacgcc      840

gtcttcgacg tcgacgtggt cttcgatgtg aatgacctcg agccgcaggt gacgtggggc      900

accaatccgg ggcaggggac cggcatcagc ggcgtcgtgc cggatccgaa ggacgcgaag      960

tccgatgagg aggcgctggc cattcgacag gcgcttgagt acatggacct gaagccggga     1020

accaaaatct ccgagatccc catccagcac gtgttcatcg gatcgtgcac caacgcccgc     1080

atcgaggatc tgcgcttggc cgcgagcatc gtcaagggcc ggcgcgtcgc ggatggcgtg     1140

cgcgcggtgg tcgtgccggg atcgaaacag gtgaagcagc aggcggaggc cgaggggctt     1200

cacgagatct tcctcgaagc gggcttcgag tggcgcgagc ccggctgcag cgcgtgtctc     1260

ggcatgaatc ccgacatcat cccggctggg gagcggtgcg catcgacgtc caaccgcaac     1320

ttcgaaggcc ggcagggcaa aggggcccgc acgcacctcg tcagcccggc catggcggcc     1380

gccgcggcca tcgcggggca cttcgtcgac gtgcgcgaac tgacctcgga aggagtgacg     1440

gcgtga                                                                1446


<210>   256
<211>   203
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   256
Met Met Glu Pro Met Val Arg His Glu Gly Leu Val Val Cys Met Asn 
                5                   10                  15      

Arg Val Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys 
            20                  25                  30          

Arg Ile Glu Arg Asp Gly Phe Gly Glu Phe Leu Phe Phe Asp Trp Arg 
        35                  40                  45              

Tyr Leu Pro Asp Gly Ser Pro Asn Pro Asp Phe Glu Leu Asn Gln Pro 
    50                  55                  60                  

Glu Ala Gln Gly Ala Thr Ile Leu Leu Val Asp Asp Asn Phe Gly Cys 
65                  70                  75                  80  

Gly Ser Ser Arg Glu His Ala Val Trp Ala Leu Arg Asp Tyr Gly Phe 
                85                  90                  95      

Arg Val Ile Leu Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys 
            100                 105                 110         

Phe Lys Asn Gly Leu Leu Pro Ile Arg Ile Pro Arg Glu Leu Tyr Lys 
        115                 120                 125             

Gln Leu Ser Glu Ser His Ala Arg Gly Glu Trp Arg Arg Met Thr Val 
    130                 135                 140                 

Asp Leu Glu Gln Gln Met Ala Ala Thr Asp His Gly Val Thr Phe Ser 
145                 150                 155                 160 

Phe Glu Ile Asp Pro His Lys Arg His Met Leu Leu Arg Gly Leu Asp 
                165                 170                 175     

Asp Ile Gly Ile Thr Leu Gln Tyr Glu Ala Asp Ile Ala Ala Tyr Glu 
            180                 185                 190         

Ala Ser Arg Arg Pro Tyr Gln Phe Val Tyr Ala 
        195                 200             

<210>   257
<211>   612
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   257
gtgatggagc ccatggtcag gcacgaaggc ctcgtggtct gcatgaaccg cgtgaacgtg       60

gacacggatc aaatcatccc gaaacaattt ctcaagcgga tcgagcgcga tggattcggc      120

gagttcctgt tcttcgactg gcggtacctg ccggacggat cgcccaaccc cgacttcgag      180

ctgaatcagc cggaggccca aggcgcgacc atcttgctcg tcgacgacaa cttcggctgc      240

ggatcgtccc gcgaacacgc ggtctgggcg cttcgcgact acgggtttcg ggtcatcctc      300

gccccgtcgt tcgccgacat cttctacaac aactgcttca aaaacggcct tctgcccatt      360

cgcatcccgc gcgagctcta caagcaactc tcggagtcgc acgcgcgcgg cgaatggcgg      420

cgcatgacgg tggatctcga gcagcagatg gccgcgaccg atcacggcgt gaccttttcc      480

ttcgagatcg atccgcacaa gcggcacatg ctgctccgtg ggctcgacga catcggcatc      540

acgctccaat acgaggccga tatcgccgcg tacgaggcct cgcgccgccc gtatcagttc      600

gtctacgcgt aa                                                          612


<210>   258
<211>   194
<212>   PRT
<213>   3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Score: 257 Significance: 3e-67 Identities: 128/196 Positives: 148/196 Gaps: 2/196

<400>   258
Met Arg Pro Phe Thr Arg Glu Thr Gly Leu Ala Val Pro Leu Asp Arg 
                5                   10                  15      

Val Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys Arg 
            20                  25                  30          

Ile Glu Arg Thr Gly Phe Gly Gln Phe Leu Phe His Asp Trp Arg Tyr 
        35                  40                  45              

Leu Pro Asp Gly Ser Pro Asn Pro Glu Phe Val Leu Asn Arg Pro Gln 
    50                  55                  60                  

Tyr Ala Gly Ala Thr Ile Leu Ile Ala Gly Arg Asn Phe Gly Ser Gly 
65                  70                  75                  80  

Ser Ser Arg Glu His Ala Pro Trp Ala Leu Ser Asp Tyr Gly Phe Arg 
                85                  90                  95      

Ala Ile Ile Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys Phe 
            100                 105                 110         

Gln Asn Gly Leu Leu Pro Val Val Leu Pro Glu Glu Ala Val Ala Glu 
        115                 120                 125             

Leu Met Arg Arg Ala Gln Glu Pro Gly Tyr Arg Leu Thr Val Asp Leu 
    130                 135                 140                 

Glu Arg Cys Val Val Glu Asp Asp Ala Gly Phe Arg Val Asp Phe Ala 
145                 150                 155                 160 

Ile Asp Ala Phe Arg Arg His Arg Met Leu His Gly Leu Asp Asp Ile 
                165                 170                 175     

Gly Leu Thr Leu Gln Tyr Glu Asp Glu Ile Ala Ala Tyr Glu Ala Arg 
            180                 185                 190         

Arg Pro 
        

<210>   259
<211>   195
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   259
Met Lys Pro Phe Thr Ile His Arg Gly Lys Thr Ala Gly Ile Asp Arg 
                5                   10                  15      

Ala Asn Ile Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys Arg 
            20                  25                  30          

Ile Glu Arg Thr Gly Phe Gly Gln Phe Leu Phe Tyr Asp Trp Arg Tyr 
        35                  40                  45              

Leu Ser Asp Gly Thr Pro Asn Pro Glu Phe Glu Leu Asn Arg Pro Glu 
    50                  55                  60                  

Asn Glu Gly Ala Thr Ile Leu Val Ala Asp Glu Asn Phe Gly Cys Gly 
65                  70                  75                  80  

Ser Ser Arg Glu His Ala Pro Trp Ala Leu Gln Asp Tyr Gly Phe Arg 
                85                  90                  95      

Val Ile Ile Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys Leu 
            100                 105                 110         

Lys Asn Gly Leu Leu Pro Ile Arg Leu Asp Lys Glu Asp Val Arg Tyr 
        115                 120                 125             

Leu Leu Arg Gln Ser Glu Arg Ala Asp Tyr Glu Leu Thr Val Ser Leu 
    130                 135                 140                 

Glu Glu Gln Arg Val Phe Asp Asp Glu Gly Phe Ser Arg Pro Phe Asp 
145                 150                 155                 160 

Ile Asp Pro Tyr Arg Lys Gln Leu Leu Leu Lys Gly Trp Asp Glu Ile 
                165                 170                 175     

Asp Leu Thr Phe Val Tyr Glu Ala His Ile Ala Ala Tyr Glu Arg Arg 
            180                 185                 190         

His Cys Pro 
        195 

<210>   260
<211>   195
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   260
Met Lys Pro Phe Thr Ile His Arg Gly Lys Thr Ala Gly Ile Asp Arg 
                5                   10                  15      

Val Asn Ile Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys Arg 
            20                  25                  30          

Ile Glu Arg Thr Gly Phe Gly Gln Phe Leu Phe Tyr Asp Trp Arg Tyr 
        35                  40                  45              

Leu Ser Asp Gly Thr Pro Asn Pro Glu Phe Glu Leu Asn Arg Pro Glu 
    50                  55                  60                  

Asn Glu Gly Ala Thr Ile Leu Val Ala Gly Asp Asn Phe Gly Cys Gly 
65                  70                  75                  80  

Ser Ser Arg Glu His Ala Pro Trp Ala Leu Gln Asp Tyr Gly Phe Arg 
                85                  90                  95      

Ala Ile Ile Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys Leu 
            100                 105                 110         

Lys Asn Gly Leu Leu Pro Ile Arg Leu Asp Gln Glu Asp Val Arg Tyr 
        115                 120                 125             

Leu Leu Gln Gln Ser Glu Arg Ala Asp Tyr Glu Leu Thr Val Ser Leu 
    130                 135                 140                 

Glu Glu Gln Arg Val Phe Asp Asp Glu Gly Phe Ser Arg Pro Phe Asp 
145                 150                 155                 160 

Ile Asp Pro Tyr Arg Lys Lys Leu Leu Leu Lys Gly Trp Asp Glu Ile 
                165                 170                 175     

Asp Leu Thr Phe Val Tyr Glu Ser His Ile Ala Ala Tyr Glu Gln Lys 
            180                 185                 190         

His Cys Pro 
        195 

<210>   261
<211>   193
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   261
Met Glu Pro Leu Lys Thr His Asn Gly Ile Ala Ala Val Leu Asn Arg 
                5                   10                  15      

Ile Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys Arg 
            20                  25                  30          

Ile Glu Arg Thr Gly Tyr Gly Arg Phe Ala Phe Phe Asp Trp Arg Tyr 
        35                  40                  45              

Leu Asp Asn Gly Asp Pro Asn Pro Asp Phe Glu Leu Asn Arg Pro Glu 
    50                  55                  60                  

Tyr Lys Gly Ala Ser Ile Leu Ile Ala Gly Glu Asn Phe Gly Cys Gly 
65                  70                  75                  80  

Ser Ser Arg Glu His Ala Pro Trp Ala Leu Asp Asp Tyr Gly Phe Lys 
                85                  90                  95      

Ile Ile Ile Ala Pro Ser Phe Ala Asp Ile Phe His Gln Asn Cys Phe 
            100                 105                 110         

Lys Asn Gly Met Leu Pro Ile Arg Leu Pro Tyr Glu Ala Trp Lys Glu 
        115                 120                 125             

Leu Ala Glu Gln Tyr Glu Tyr Gln Ser Leu Thr Met Thr Val Asp Leu 
    130                 135                 140                 

Glu Lys Gln Thr Ile Thr Asp His Ala Gly Arg Gln Ile Ala Phe Glu 
145                 150                 155                 160 

Val Asp Pro His Trp Lys Glu Met Leu Leu Asn Gly Tyr Asp Glu Ile 
                165                 170                 175     

Ser Leu Thr Leu Leu Leu Glu Glu Glu Ile Glu Gln Phe Glu Lys Gln 
            180                 185                 190         

Arg 
    

<210>   262
<211>   193
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   262
Met Glu Pro Leu Val Thr His Lys Gly Lys Ala Ala Val Leu Asn Arg 
                5                   10                  15      

Ile Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys Arg 
            20                  25                  30          

Ile Glu Arg Thr Gly Tyr Gly Arg Phe Ala Phe Phe Asp Trp Arg Tyr 
        35                  40                  45              

Leu Ala Asp Gly Ser Pro Asn Pro Asp Phe Glu Leu Asn Gln Pro Ile 
    50                  55                  60                  

Tyr Glu Gly Ser Ser Ile Leu Ile Ala Gly Glu Asn Phe Gly Cys Gly 
65                  70                  75                  80  

Ser Ser Arg Glu His Ala Pro Trp Ala Leu Asp Asp Tyr Gly Phe Lys 
                85                  90                  95      

Ile Val Ile Ala Pro Ser Phe Ala Asp Ile Phe His Gln Asn Cys Phe 
            100                 105                 110         

Lys Asn Gly Met Leu Pro Ile Arg Leu Asp Tyr Asp Val Trp Lys Thr 
        115                 120                 125             

Phe Ala Ala Ser Tyr Glu Asn Lys Gly Tyr Glu Met Thr Val Asp Leu 
    130                 135                 140                 

Glu Lys Gln Gln Ile Glu Asp His Glu Gly Asn Ile Thr Pro Phe Asp 
145                 150                 155                 160 

Val Asp Pro His Trp Arg Glu Met Leu Leu Asn Gly Tyr Asp Glu Ile 
                165                 170                 175     

Ser Leu Thr Leu Leu Leu Glu Asp Asp Ile Gln Ala Phe Glu Asp Lys 
            180                 185                 190         

Arg 
    

<210>   263
<211>   203
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   263
Met Met Glu Pro Met Val Arg His Glu Gly Leu Val Val Cys Met Asn 
                5                   10                  15      

Arg Val Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys 
            20                  25                  30          

Arg Ile Glu Arg Asp Gly Phe Gly Glu Phe Leu Phe Phe Asp Trp Arg 
        35                  40                  45              

Tyr Leu Pro Asp Gly Ser Pro Asn Pro Asp Phe Glu Leu Asn Gln Pro 
    50                  55                  60                  

Glu Ala Gln Gly Ala Thr Ile Leu Leu Val Asp Asp Asn Phe Gly Cys 
65                  70                  75                  80  

Gly Ser Ser Arg Glu His Ala Val Trp Ala Leu Arg Asp Tyr Gly Phe 
                85                  90                  95      

Arg Val Ile Leu Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys 
            100                 105                 110         

Phe Lys Asn Gly Leu Leu Pro Ile Arg Ile Pro Arg Glu Leu Tyr Lys 
        115                 120                 125             

Asn Leu Ser Glu Ser His Ala Arg Gly Glu Trp Arg Arg Met Thr Val 
    130                 135                 140                 

Asp Leu Glu Gln Gln Met Ala Ala Thr Asp His Gly Val Thr Phe Ser 
145                 150                 155                 160 

Phe Glu Ile Asp Pro His Lys Arg His Met Leu Leu Arg Gly Leu Asp 
                165                 170                 175     

Asp Ile Gly Ile Thr Leu Gln Tyr Glu Ala Asp Ile Ala Ala Tyr Glu 
            180                 185                 190         

Ala Ser Arg Arg Pro Tyr Gln Phe Val Tyr Ala 
        195                 200             

<210>   264
<211>   203
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   264
Met Met Glu Pro Met Val Arg His Glu Gly Leu Val Val Cys Met Asn 
                5                   10                  15      

Arg Val Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys 
            20                  25                  30          

Arg Ile Glu Arg Asp Gly Phe Gly Glu Phe Ile Phe Phe Asp Trp Arg 
        35                  40                  45              

Tyr Leu Pro Asp Gly Ser Pro Asn Pro Asp Phe Glu Leu Asn Gln Pro 
    50                  55                  60                  

Glu Ala Gln Gly Ala Thr Ile Leu Leu Val Asp Asp Asn Phe Gly Cys 
65                  70                  75                  80  

Gly Ser Ser Arg Glu His Ala Val Trp Ala Leu Arg Asp Tyr Gly Phe 
                85                  90                  95      

Arg Val Ile Leu Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys 
            100                 105                 110         

Phe Lys Asn Gly Leu Leu Pro Ile Arg Ile Pro Arg Glu Leu Tyr Lys 
        115                 120                 125             

Gln Leu Ser Glu Ser His Ala Arg Gly Glu Trp Arg Arg Met Thr Val 
    130                 135                 140                 

Asp Leu Glu Gln Gln Met Ala Ala Thr Asp His Gly Val Thr Phe Ser 
145                 150                 155                 160 

Phe Glu Ile Asp Pro His Lys Arg His Met Leu Leu Arg Gly Leu Asp 
                165                 170                 175     

Asp Ile Gly Ile Thr Leu Gln Tyr Glu Ala Asp Ile Ala Ala Tyr Glu 
            180                 185                 190         

Ala Ser Arg Arg Pro Tyr Gln Phe Val Tyr Ala 
        195                 200             

<210>   265
<211>   203
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   265
Met Met Glu Pro Met Val Arg His Glu Gly Leu Val Val Cys Met Asn 
                5                   10                  15      

Arg Val Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys 
            20                  25                  30          

Arg Ile Glu Arg Asp Gly Phe Gly Glu Phe Leu Phe Phe Asp Trp Arg 
        35                  40                  45              

Tyr Leu Pro Asp Gly Ser Pro Asn Pro Asp Phe Glu Leu Asn Gln Pro 
    50                  55                  60                  

Glu Ala Gln Gly Ala Thr Ile Leu Leu Val Asp Asp Asn Phe Gly Cys 
65                  70                  75                  80  

Gly Ser Ser Arg Glu His Ala Val Trp Ala Leu Arg Asp Tyr Gly Phe 
                85                  90                  95      

Arg Val Ile Leu Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys 
            100                 105                 110         

Phe Lys Asn Gly Leu Leu Pro Ile Arg Ile Pro Arg Glu Leu Tyr Lys 
        115                 120                 125             

Gln Leu Ser Glu Ser His Ala Arg Gly Glu Trp Arg Lys Met Thr Val 
    130                 135                 140                 

Asp Leu Glu Gln Gln Met Ala Ala Thr Asp His Gly Val Thr Phe Ser 
145                 150                 155                 160 

Phe Glu Ile Asp Pro His Lys Arg His Met Leu Leu Arg Gly Leu Asp 
                165                 170                 175     

Asp Ile Gly Ile Thr Leu Gln Tyr Glu Ala Asp Ile Ala Ala Tyr Glu 
            180                 185                 190         

Ala Ser Arg Arg Pro Tyr Gln Phe Val Tyr Ala 
        195                 200             

<210>   266
<211>   203
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   266
Met Met Glu Pro Met Val Arg His Glu Gly Leu Val Val Cys Met Asn 
                5                   10                  15      

Arg Val Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys 
            20                  25                  30          

Arg Ile Glu Arg Asp Gly Phe Gly Glu Phe Leu Phe Phe Asp Trp Arg 
        35                  40                  45              

Tyr Leu Pro Asp Gly Ser Pro Asn Pro Asp Phe Glu Leu Asn Gln Pro 
    50                  55                  60                  

Glu Ala Asn Gly Ala Thr Ile Leu Leu Val Asp Asp Asn Phe Gly Cys 
65                  70                  75                  80  

Gly Ser Ser Arg Glu His Ala Val Trp Ala Leu Arg Asp Tyr Gly Phe 
                85                  90                  95      

Arg Val Ile Leu Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys 
            100                 105                 110         

Phe Lys Asn Gly Leu Leu Pro Ile Arg Ile Pro Arg Glu Leu Tyr Lys 
        115                 120                 125             

Gln Leu Ser Glu Ser His Ala Arg Gly Glu Trp Arg Arg Met Thr Val 
    130                 135                 140                 

Asp Leu Glu Gln Gln Met Ala Ala Thr Asp His Gly Val Thr Phe Ser 
145                 150                 155                 160 

Phe Glu Ile Asp Pro His Lys Arg His Met Leu Leu Arg Gly Leu Asp 
                165                 170                 175     

Asp Ile Gly Ile Thr Leu Gln Tyr Glu Ala Asp Ile Ala Ala Tyr Glu 
            180                 185                 190         

Ala Ser Arg Arg Pro Tyr Gln Phe Val Tyr Ala 
        195                 200             

<210>   267
<211>   203
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   267
Met Met Glu Pro Met Val Arg His Glu Gly Leu Val Val Cys Met Asn 
                5                   10                  15      

Arg Val Asn Val Asp Thr Asp Gln Ile Ile Pro Lys Gln Phe Leu Lys 
            20                  25                  30          

Arg Ile Glu Arg Asp Gly Phe Gly Glu Phe Leu Phe Phe Asp Trp Arg 
        35                  40                  45              

Tyr Leu Pro Asp Gly Ser Pro Asn Pro Asp Phe Glu Leu Asn Gln Pro 
    50                  55                  60                  

Asp Ala Gln Gly Ala Thr Ile Leu Leu Val Asp Asp Asn Phe Gly Cys 
65                  70                  75                  80  

Gly Ser Ser Arg Glu His Ala Val Trp Ala Leu Arg Asp Tyr Gly Phe 
                85                  90                  95      

Arg Val Ile Leu Ala Pro Ser Phe Ala Asp Ile Phe Tyr Asn Asn Cys 
            100                 105                 110         

Phe Lys Asn Gly Leu Leu Pro Ile Arg Ile Pro Arg Glu Leu Tyr Lys 
        115                 120                 125             

Gln Leu Ser Glu Ser His Ala Arg Gly Glu Trp Arg Arg Met Thr Val 
    130                 135                 140                 

Asp Leu Glu Gln Gln Met Ala Ala Thr Asp His Gly Val Thr Phe Ser 
145                 150                 155                 160 

Phe Glu Ile Asp Pro His Lys Arg His Met Leu Leu Arg Gly Leu Asp 
                165                 170                 175     

Asp Ile Gly Ile Thr Leu Gln Tyr Glu Ala Asp Ile Ala Ala Tyr Glu 
            180                 185                 190         

Ala Ser Arg Arg Pro Tyr Gln Phe Val Tyr Ala 
        195                 200             

<210>   268
<211>   612
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   268
gtgatggagc ccatggtcag gcacgaaggc ctcgtggtct gcatgaaccg cgtgaacgtg       60

gacacggatc aaatcatccc gaaacaattt ctcaagcgga tcgagcgcga tggattcggc      120

gagttcctgt tcttcgactg gcggtacctg ccggacggat cgcccaaccc cgacttcgag      180

ctgaatcagc cggaggccca aggcgcgacc atcttgctcg tcgacgacaa cttcggctgc      240

ggatcgtccc gcgaacacgc ggtctgggcg cttcgcgact acgggtttcg ggtcatcctc      300

gccccgtcgt tcgccgacat cttctacaac aactgcttca aaaacggcct tctgcccatt      360

cgcatcccgc gcgagctcta caagaatctc tcggagtcgc acgcgcgcgg cgaatggcgg      420

cgcatgacgg tggatctcga gcagcagatg gccgcgaccg atcacggcgt gaccttttcc      480

ttcgagatcg atccgcacaa gcggcacatg ctgctccgtg ggctcgacga catcggcatc      540

acgctccaat acgaggccga tatcgccgcg tacgaggcct cgcgccgccc gtatcagttc      600

gtctacgcgt aa                                                          612


<210>   269
<211>   612
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   269
gtgatggagc ccatggtcag gcacgaaggc ctcgtggtct gcatgaaccg cgtgaacgtg       60

gacacggatc aaatcatccc gaaacaattt ctcaagcgga tcgagcgcga tggattcggc      120

gagttcattt tcttcgactg gcggtacctg ccggacggat cgcccaaccc cgacttcgag      180

ctgaatcagc cggaggccca aggcgcgacc atcttgctcg tcgacgacaa cttcggctgc      240

ggatcgtccc gcgaacacgc ggtctgggcg cttcgcgact acgggtttcg ggtcatcctc      300

gccccgtcgt tcgccgacat cttctacaac aactgcttca aaaacggcct tctgcccatt      360

cgcatcccgc gcgagctcta caagcaactc tcggagtcgc acgcgcgcgg cgaatggcgg      420

cgcatgacgg tggatctcga gcagcagatg gccgcgaccg atcacggcgt gaccttttcc      480

ttcgagatcg atccgcacaa gcggcacatg ctgctccgtg ggctcgacga catcggcatc      540

acgctccaat acgaggccga tatcgccgcg tacgaggcct cgcgccgccc gtatcagttc      600

gtctacgcgt aa                                                          612


<210>   270
<211>   612
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   270
gtgatggagc ccatggtcag gcacgaaggc ctcgtggtct gcatgaaccg cgtgaacgtg       60

gacacggatc aaatcatccc gaaacaattt ctcaagcgga tcgagcgcga tggattcggc      120

gagttcctgt tcttcgactg gcggtacctg ccggacggat cgcccaaccc cgacttcgag      180

ctgaatcagc cggaggccca aggcgcgacc atcttgctcg tcgacgacaa cttcggctgc      240

ggatcgtccc gcgaacacgc ggtctgggcg cttcgcgact acgggtttcg ggtcatcctc      300

gccccgtcgt tcgccgacat cttctacaac aactgcttca aaaacggcct tctgcccatt      360

cgcatcccgc gcgagctcta caagcaactc tcggagtcgc acgcgcgcgg cgaatggcgg      420

aaaatgacgg tggatctcga gcagcagatg gccgcgaccg atcacggcgt gaccttttcc      480

ttcgagatcg atccgcacaa gcggcacatg ctgctccgtg ggctcgacga catcggcatc      540

acgctccaat acgaggccga tatcgccgcg tacgaggcct cgcgccgccc gtatcagttc      600

gtctacgcgt aa                                                          612


<210>   271
<211>   612
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   271
gtgatggagc ccatggtcag gcacgaaggc ctcgtggtct gcatgaaccg cgtgaacgtg       60

gacacggatc aaatcatccc gaaacaattt ctcaagcgga tcgagcgcga tggattcggc      120

gagttcctgt tcttcgactg gcggtacctg ccggacggat cgcccaaccc cgacttcgag      180

ctgaatcagc cggaggccaa tggcgcgacc atcttgctcg tcgacgacaa cttcggctgc      240

ggatcgtccc gcgaacacgc ggtctgggcg cttcgcgact acgggtttcg ggtcatcctc      300

gccccgtcgt tcgccgacat cttctacaac aactgcttca aaaacggcct tctgcccatt      360

cgcatcccgc gcgagctcta caagcaactc tcggagtcgc acgcgcgcgg cgaatggcgg      420

cgcatgacgg tggatctcga gcagcagatg gccgcgaccg atcacggcgt gaccttttcc      480

ttcgagatcg atccgcacaa gcggcacatg ctgctccgtg ggctcgacga catcggcatc      540

acgctccaat acgaggccga tatcgccgcg tacgaggcct cgcgccgccc gtatcagttc      600

gtctacgcgt aa                                                          612


<210>   272
<211>   612
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   272
gtgatggagc ccatggtcag gcacgaaggc ctcgtggtct gcatgaaccg cgtgaacgtg       60

gacacggatc aaatcatccc gaaacaattt ctcaagcgga tcgagcgcga tggattcggc      120

gagttcctgt tcttcgactg gcggtacctg ccggacggat cgcccaaccc cgacttcgag      180

ctgaatcagc cggatgccca aggcgcgacc atcttgctcg tcgacgacaa cttcggctgc      240

ggatcgtccc gcgaacacgc ggtctgggcg cttcgcgact acgggtttcg ggtcatcctc      300

gccccgtcgt tcgccgacat cttctacaac aactgcttca aaaacggcct tctgcccatt      360

cgcatcccgc gcgagctcta caagcaactc tcggagtcgc acgcgcgcgg cgaatggcgg      420

cgcatgacgg tggatctcga gcagcagatg gccgcgaccg atcacggcgt gaccttttcc      480

ttcgagatcg atccgcacaa gcggcacatg ctgctccgtg ggctcgacga catcggcatc      540

acgctccaat acgaggccga tatcgccgcg tacgaggcct cgcgccgccc gtatcagttc      600

gtctacgcgt aa                                                          612


<210>   273
<211>   377
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   273
Met Ala Ala Glu Thr Thr Phe Lys Ala Gly Leu Glu Asp Val Val Ser 
                5                   10                  15      

Asn Thr Ser Glu Ile Cys Phe Leu Asp Gly Lys Gln Gly Arg Leu Leu 
            20                  25                  30          

Tyr Tyr Gly Tyr Asp Ile His Asp Leu Val Asp Gly Gly Ala Ser Phe 
        35                  40                  45              

Glu Glu Val Val Tyr Leu Leu Trp His Gly Glu Leu Pro Asn Gln Ser 
    50                  55                  60                  

Glu Leu Lys Ala Phe Thr Glu Glu Leu Ala Ser Glu Arg Ala Leu Ala 
65                  70                  75                  80  

Glu Pro Val Leu Asp Leu Leu Lys Arg Leu Pro Lys Asp Ala Asn Ala 
                85                  90                  95      

Met Ala Val Leu Arg Thr Ala Val Ser Phe Leu Gly Leu Tyr Asp Pro 
            100                 105                 110         

Asp Asp Gly Asp Glu Ser Leu Glu Ala Asn Tyr Arg Lys Ala Ala Arg 
        115                 120                 125             

Leu Val Ala Lys Ile Pro Thr Ile Val Thr Ser Tyr Glu Arg Ile Arg 
    130                 135                 140                 

Gln Gly Leu Asp Pro Val Gln Pro Asp Pro Ser Leu Ser Ala Ala Ala 
145                 150                 155                 160 

Asn Phe Phe Tyr Leu Leu Arg Gly Thr Lys Pro Ser Glu Phe Glu Glu 
                165                 170                 175     

Lys Ala Phe Asn Thr Ala Leu Ile Leu His Ala Asp His Glu Leu Asn 
            180                 185                 190         

Ala Ser Thr Phe Ser Ala Arg Val Thr Ala Gly Thr Leu Ser Asp Met 
        195                 200                 205             

Tyr Ser Ala Ile Thr Ser Ala Ile Gly Thr Leu Lys Gly Pro Leu His 
    210                 215                 220                 

Gly Gly Ala Asn Glu Gln Val Met Arg Met Leu Leu Glu Ile Gly Asp 
225                 230                 235                 240 

Pro Ser Lys Ala Ile Thr Trp Ile Asp Glu Ala Leu Ala Gln Lys Lys 
                245                 250                 255     

Lys Ile Met Gly Phe Gly His Arg Val Tyr Arg Thr Glu Asp Pro Arg 
            260                 265                 270         

Ala Thr His Leu Arg Glu Leu Ser Lys Gln Ala Gly Glu Leu Lys Gly 
        275                 280                 285             

Glu Thr Lys Trp Phe Glu Met Ser Gln Ala Ile Glu Lys His Met Leu 
    290                 295                 300                 

Glu Val Lys Gly Leu His Ala Asn Val Asp Phe Tyr Ser Ala Ser Leu 
305                 310                 315                 320 

Tyr Tyr Ser Leu Gly Ile Pro Thr His Leu Tyr Thr Pro Ile Phe Ala 
                325                 330                 335     

Cys Ser Arg Ile Ser Gly Trp Thr Ala His Val Leu Glu Gln Tyr Lys 
            340                 345                 350         

Asn Asn Arg Leu Ile Arg Pro Arg Ala Glu Tyr Val Gly Pro Thr Asp 
        355                 360                 365             

Arg Lys Phe Val Pro Leu Ser Glu Arg 
    370                 375         

<210>   274
<211>   1134
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   274
atggcagcgg aaacgacatt caaagccggg ctggaagacg tggtctccaa cacgtctgaa       60

atctgcttct tggatgggaa acagggtcgc cttctgtact acggatatga tatccacgat      120

ctcgtcgatg gcggcgcctc gtttgaggag gtcgtgtacc ttctgtggca cggcgagctg      180

ccgaatcagt cggagctgaa agcgttcacc gaggaactcg ccagcgagcg ggcattggct      240

gaacccgtgc tcgatctctt gaaacgcctc ccgaaggacg cgaatgcgat ggccgtactt      300

cgcacggcgg tctccttcct cggtctgtat gatcccgatg acggcgatga gagcctggag      360

gcaaactacc gcaaagccgc gcgcctcgtc gcgaagattc caaccatcgt gacctcctac      420

gagcgcatcc gccaaggact ggaccccgta caaccggatc cttcgctgag cgccgctgcg      480

aacttcttct atctcctccg tggcacgaag ccttccgaat tcgaggagaa ggcattcaac      540

accgcactca ttctgcacgc agatcacgaa ttgaacgctt cgacgttctc ggcgcgcgtc      600

acggcgggca cgctgtcgga catgtattcc gccatcacgt cggccatcgg cacgcttaaa      660

ggtcctctgc acggcggcgc caatgagcag gtgatgcgca tgctgctcga aattggcgat      720

cccagcaagg ccatcacgtg gatcgacgag gcgctcgcgc agaagaagaa gatcatgggc      780

ttcggccatc gcgtgtatcg gaccgaggat ccgcgcgcga cgcaccttcg cgagctcagc      840

aagcaggcgg gcgagctgaa gggcgaaacg aaatggttcg agatgtccca ggccattgaa      900

aagcacatgc tcgaggtcaa gggcctgcac gcgaacgtgg acttctattc ggcgtcgctc      960

tactattcgc tcggcattcc gacgcacctg tacacgccca tcttcgcgtg cagccgcatc     1020

tccgggtgga cggcgcacgt gctcgagcag tacaagaaca atcgcctcat ccgcccgcgg     1080

gccgagtacg tcggaccgac ggatcgcaag tttgtcccgc tcagcgagcg ctga           1134


<210>   275
<211>   371
<212>   PRT
<213>   Solibacter usitatus Ellin6076

<400>   275
Thr Thr Thr Ala Gly Leu Glu Gly Ile Ile Ala Gly Glu Ser Glu Ile 
                5                   10                  15      

Cys Tyr Ile Asp Gly Tyr Leu Gly Ile Leu Ser Tyr Arg Gly Phe Asn 
            20                  25                  30          

Ile His Thr Leu Ala Asp Asn Ala Lys Phe Glu Glu Val Ile Phe Leu 
        35                  40                  45              

Leu Trp Asn Gly Trp Leu Pro Arg Gln Ala Glu Leu Asp Ala Leu Lys 
    50                  55                  60                  

Ala Ala Leu Val Ala Glu Arg Glu Leu Pro Gly Ala Ile Val Asp Phe 
65                  70                  75                  80  

Leu Lys Ser Ala Pro Lys Val Asn Thr Met Asp Leu Leu Arg Thr Ala 
                85                  90                  95      

Val Ser Met Leu Ser Leu His Asp Ala Glu Ala Gln Asp Met Ser Ala 
            100                 105                 110         

Glu Ala Asn His Arg Lys Ala Ile Arg Leu Met Ser Lys Thr Ala Thr 
        115                 120                 125             

Leu Val Thr Thr Tyr Asp Arg Leu Arg Asn Gly Lys Glu Val Ile Pro 
    130                 135                 140                 

Gly Asp Pro Lys Leu Ser Phe Ala Ala Asn Phe Leu Tyr Thr Leu Thr 
145                 150                 155                 160 

Gly Asn Arg Pro Asp Glu Ile Met Glu Arg Ala Phe Asp Val Ala Met 
                165                 170                 175     

Thr Leu His Ala Asp His Glu Leu Asn Ala Ser Thr Phe Ala Ala Arg 
            180                 185                 190         

Val Val Ala Ala Thr Leu Ser Asp Ile Tyr Ser Ala Ile Thr Ala Gly 
        195                 200                 205             

Ile Gly Ala Leu Lys Gly Pro Leu His Gly Gly Ala Asn Gln Asp Val 
    210                 215                 220                 

Ile Lys Trp Leu Leu Ser Leu Gly Asp Glu Glu Glu Ala Val Lys Ala 
225                 230                 235                 240 

Val Glu Asn Thr Leu Ala Arg Lys Val Lys Ile Pro Gly Phe Gly His 
                245                 250                 255     

Arg Val Tyr Arg Thr Asp Asp Pro Arg Ala Thr His Leu Arg Val Leu 
            260                 265                 270         

Ser Glu Glu Leu Gly Lys Arg Thr Gly His Glu Lys Leu Tyr Arg Leu 
        275                 280                 285             

Ser Gln Arg Met Glu Ala Thr Val Lys Gly Ile Lys Gly Leu Asn Pro 
    290                 295                 300                 

Asn Val Asp Phe Tyr Ser Ala Ser Ala Tyr Tyr Ser Leu Gly Ile Pro 
305                 310                 315                 320 

Ile Asp Leu Tyr Thr Pro Ile Phe Ala Val Ser Arg Met Ser Gly Trp 
                325                 330                 335     

Thr Ala His Val Leu Glu Gln Tyr Arg Asn Asn Arg Leu Ile Arg Pro 
            340                 345                 350         

Arg Ala Glu Tyr Lys Gly Asn Pro Asp Gly Gln Thr Trp Ile Pro Ile 
        355                 360                 365             

Asp Lys Arg 
    370     

<210>   276
<211>   370
<212>   PRT
<213>   Candidatus Chloracidobacterium thermophilum

<400>   276
Phe Val Lys Gly Leu Glu Gly Val Leu Ala Ala Gln Ser Ser Ile Cys 
                5                   10                  15      

Phe Ile Asp Gly Ala Ala Gly Arg Leu Thr Tyr Arg Gly Ile Asp Ile 
            20                  25                  30          

His Val Leu Ala Glu His Ser Thr Phe Glu Glu Thr Ala Tyr Phe Leu 
        35                  40                  45              

Leu Phe Gly His Leu Pro Lys Gln Ala Glu Leu Asp Ala Phe Thr Lys 
    50                  55                  60                  

Gln Leu Gln Ala Glu Arg Glu Val Pro Thr Glu Ile Tyr Thr Leu Leu 
65                  70                  75                  80  

Arg Thr Leu Pro Pro Thr Ala Thr Pro Met Glu Val Leu Arg Thr Ala 
                85                  90                  95      

Thr Ser Ala Leu Ser Ala Tyr Asp Pro Asp Gly Pro Asp Asn Ser Asp 
            100                 105                 110         

Glu Ala Asn Val Arg Lys Gly Ile Arg Leu Ile Ala Arg Met Thr Thr 
        115                 120                 125             

Leu Thr Thr Ala Tyr Asp Arg Ile Arg Arg Gly Leu Glu Pro Val Lys 
    130                 135                 140                 

Pro Asp Pro Ser Leu Ser Met Ala Glu Ser Phe Leu Tyr Gly Leu Thr 
145                 150                 155                 160 

Gly Glu Lys Pro His Pro Ser Ser Ala Arg Val Phe Asp Val Cys Leu 
                165                 170                 175     

Ile Leu His Ala Asp His Glu Leu Asn Ala Ser Thr Phe Ala Ala Arg 
            180                 185                 190         

Val Ile Ala Ser Thr Leu Ser Asp Met Tyr Ala Ala Ile Thr Gly Ala 
        195                 200                 205             

Ile Gly Ala Leu Ala Gly Ser Leu His Gly Gly Ala Asn Gln Arg Val 
    210                 215                 220                 

Leu Glu Met Leu Leu Glu Ile Gly Glu Leu Asp Lys Val Glu Ala Tyr 
225                 230                 235                 240 

Val Asp Asn Leu Phe Ala Asn Lys Lys Lys Ile Met Gly Phe Gly His 
                245                 250                 255     

Arg Val Tyr Arg Thr Met Asp Pro Arg Ala Thr Val Leu Arg Lys Phe 
            260                 265                 270         

Ala Lys Gln Leu Gly Glu Asp Val Gly Asn Thr Lys Trp Tyr Glu Met 
        275                 280                 285             

Ala Glu Arg Ile Glu Gln Leu Ala Phe Ala Arg Lys Lys Leu Tyr Pro 
    290                 295                 300                 

Asn Val Asp Phe Phe Ser Ala Pro Val Phe Tyr Thr Leu Asn Ile Pro 
305                 310                 315                 320 

Val Asp Leu Phe Thr Pro Ile Phe Ala Cys Ser Arg Ile Ser Gly Trp 
                325                 330                 335     

Val Ala His Thr Leu Glu Gln Leu Arg Asp Asn Arg Leu Ile Arg Pro 
            340                 345                 350         

Leu Ala Leu Tyr Thr Gly Pro Glu Gln Ala Glu Tyr Ile Pro Ile Ser 
        355                 360                 365             

Glu Arg 
    370 

<210>   277
<211>   370
<212>   PRT
<213>   Bacillus methanolicus

<400>   277
Thr Val Thr Arg Gly Leu Glu Gly Val Val Ala Thr Thr Ser Ser Ile 
                5                   10                  15      

Ser Ser Ile Ile Asp Asp Thr Leu Thr Tyr Val Gly Tyr Asn Ile Asp 
            20                  25                  30          

Asp Leu Ala Asp Asn Ala Ser Phe Glu Glu Val Ile Phe Leu Leu Trp 
        35                  40                  45              

His Arg Lys Leu Pro Thr Lys Ser Glu Leu Glu Glu Leu Lys Ile Leu 
    50                  55                  60                  

Leu Ala Glu Asn Ala Glu Leu Pro Lys Glu Ile Leu Asp His Phe Lys 
65                  70                  75                  80  

Met Tyr Pro Ile Asp Lys Val His Pro Met Ala Ala Leu Arg Ser Ala 
                85                  90                  95      

Val Ser Leu Leu Gly Leu Tyr Asp Glu Glu Ala Asp Leu Met Asp Glu 
            100                 105                 110         

Glu Ala Asn Tyr Arg Lys Ala Ile Arg Leu Gln Ala Lys Ile Pro Ser 
        115                 120                 125             

Ile Val Ala Ala Phe Ala Arg Val Arg Lys Gly Leu Glu Pro Val Ala 
    130                 135                 140                 

Pro Arg Lys Asp Leu Ser Phe Ala Ala Asn Phe Leu Tyr Met Leu Lys 
145                 150                 155                 160 

Gly Lys Glu Pro Glu Asp Ile Ala Val Glu Ala Phe Asn Lys Val Leu 
                165                 170                 175     

Val Leu His Ala Asp His Glu Leu Asn Ala Ser Thr Phe Thr Ala Arg 
            180                 185                 190         

Val Cys Val Ala Thr Leu Ser Asp Ile Tyr Ser Gly Val Thr Ala Ala 
        195                 200                 205             

Ile Gly Ala Leu Lys Gly Pro Leu His Gly Gly Ala Asn Glu Ala Val 
    210                 215                 220                 

Met Lys Met Leu Thr Glu Ile Gly Ser Leu Glu Asn Val Glu Pro Tyr 
225                 230                 235                 240 

Ile Arg Glu Lys Leu Ala Lys Lys Glu Lys Ile Met Gly Phe Gly His 
                245                 250                 255     

Arg Val Tyr Arg Lys Gly Asp Pro Arg Ala Lys His Leu Arg Glu Met 
            260                 265                 270         

Ser Lys Lys Leu Thr Glu Leu Thr Gly Glu Pro His Trp Tyr Glu Met 
        275                 280                 285             

Ser Thr Lys Ile Glu Ala Ile Val Thr Gly Glu Lys Gly Leu Pro Pro 
    290                 295                 300                 

Asn Val Asp Phe Tyr Ser Ala Ser Ile Tyr His Ser Leu Gly Ile Asp 
305                 310                 315                 320 

His Asp Leu Phe Thr Pro Ile Phe Ala Val Ser Arg Ile Ser Gly Trp 
                325                 330                 335     

Leu Ala His Ile Leu Glu Gln Tyr Glu Asn Asn Arg Leu Ile Arg Pro 
            340                 345                 350         

Arg Ala Asp Tyr Ile Gly Pro Gly Met Gln Lys Phe Ile Pro Ile Glu 
        355                 360                 365             

Gln Arg 
    370 

<210>   278
<211>   370
<212>   PRT
<213>   Bacillus sp. SG-1

<400>   278
Thr Ala Thr Arg Gly Leu Glu Gly Val Val Ala Thr Thr Ser Ser Ile 
                5                   10                  15      

Ser Ser Ile Ile Asp Asp Thr Leu Thr Tyr Val Gly Tyr Asn Ile Asp 
            20                  25                  30          

Asp Leu Thr Asn Asn Ala Ser Phe Glu Glu Ile Ile Tyr Leu Leu Trp 
        35                  40                  45              

Asn Leu Lys Leu Pro Thr Ala Ser Glu Leu Asp Ala Leu Lys Lys Asp 
    50                  55                  60                  

Leu Ala Glu Asn Ala Ala Leu Pro Lys Glu Val Ile Glu His Phe Lys 
65                  70                  75                  80  

Met Tyr Pro Ile Lys Asp Val His Pro Met Ala Ala Leu Arg Ser Ala 
                85                  90                  95      

Val Ser Leu Leu Gly Leu Tyr Asp Glu Glu Ala Asp Val Met Glu Glu 
            100                 105                 110         

Gly Ala Asn Phe Arg Lys Ala Val Arg Leu Gln Ala Lys Ile Pro Thr 
        115                 120                 125             

Ile Val Thr Ser Phe Ala Arg Ile Arg Ser Gly Lys Glu Pro Ile Ala 
    130                 135                 140                 

Pro Arg Thr Asp Leu Gly Phe Ala Ala Asn Phe Leu Tyr Met Leu Thr 
145                 150                 155                 160 

Gly Asn Glu Pro Ala Asp Ile Glu Val Glu Ala Phe Asn Lys Ala Leu 
                165                 170                 175     

Val Leu His Ala Asp His Glu Leu Asn Ala Ser Thr Phe Thr Ala Arg 
            180                 185                 190         

Val Cys Val Ala Thr Leu Ser Asp Val Tyr Ser Gly Val Thr Ala Ala 
        195                 200                 205             

Ile Gly Ala Leu Lys Gly Pro Leu His Gly Gly Ala Asn Glu Gln Val 
    210                 215                 220                 

Met Lys Met Leu Thr Glu Ile Asp Ser Val Asp Asn Val Glu Ser Val 
225                 230                 235                 240 

Ile Arg Glu Lys Leu Ala Asn Lys Glu Lys Ile Met Gly Phe Gly His 
                245                 250                 255     

Arg Val Tyr Gln Gln Gly Asp Pro Arg Ala Lys His Leu Lys Glu Met 
            260                 265                 270         

Ser Lys Lys Leu Thr Glu Leu Arg Gly Glu Ser Lys Tyr Tyr Glu Met 
        275                 280                 285             

Ser Thr Lys Ile Glu Glu Ile Val Thr Ser Glu Lys Gly Leu Pro Pro 
    290                 295                 300                 

Asn Val Asp Phe Tyr Ser Ala Ser Val Tyr His Ser Leu Gly Ile Asp 
305                 310                 315                 320 

His Asp Leu Phe Thr Pro Ile Phe Ala Val Ser Arg Val Ser Gly Trp 
                325                 330                 335     

Leu Ala His Ile Leu Glu Gln Tyr Ser Asn Asn Arg Leu Ile Arg Pro 
            340                 345                 350         

Arg Ala Asp Tyr Ile Gly Pro Gly Lys Gln Ala Tyr Val Pro Val Glu 
        355                 360                 365             

Gln Arg 
    370 

<210>   279
<211>   366
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   279
Gly Leu Glu Gly Val Val Ala Thr Thr Ser Ser Val Ser Ser Ile Ile 
                5                   10                  15      

Glu Ser Val Leu Thr Tyr Gln Gly Tyr Asp Ile Asp Glu Leu Ala Glu 
            20                  25                  30          

His Ala Ser Phe Glu Glu Val Ile Tyr Leu Leu Trp Asn Gly Lys Leu 
        35                  40                  45              

Pro Asn Lys Val Glu Leu Lys Glu Leu Ala Asp Glu Leu Ala Asn Asn 
    50                  55                  60                  

Ala Glu Ile Pro Gln Glu Val Ile Glu Gln Met Lys Ala Tyr Pro Leu 
65                  70                  75                  80  

Asp Arg Val His Pro Met Gly Ala Leu Arg Thr Ala Ile Ser Ser Leu 
                85                  90                  95      

Gly Leu Tyr Asp Glu Glu Ala Asp Leu Met Asp Glu Ala Ala Asn Lys 
            100                 105                 110         

Arg Lys Ala Leu Lys Leu Gln Ala Gln Val Ser Thr Val Val Thr Ala 
        115                 120                 125             

Phe Ser Arg Ile Arg Glu Gly Lys Glu Pro Val Ala Pro Arg Thr Asp 
    130                 135                 140                 

Leu Ser Phe Ala Ala Asn Phe Leu Tyr Met Leu Thr Gly Glu Glu Pro 
145                 150                 155                 160 

Asp Glu Ile Ala Val Asp Ala Phe Asn Lys Ala Leu Val Leu His Ala 
                165                 170                 175     

Asp His Glu Leu Asn Ala Ser Thr Phe Thr Ala Arg Val Cys Val Ala 
            180                 185                 190         

Thr Leu Ser Asp Val Tyr Ser Gly Ile Thr Ala Ala Ile Gly Ala Leu 
        195                 200                 205             

Lys Gly Pro Leu His Gly Gly Ala Asn Glu Gln Val Met Ala Met Leu 
    210                 215                 220                 

Thr Glu Ile Gly Asp Val Glu Asn Val Glu Pro Tyr Ile Arg Lys Ala 
225                 230                 235                 240 

Leu Asp Asn Lys Gln Lys Ile Met Gly Phe Gly His Arg Val Tyr Lys 
                245                 250                 255     

Asn Gly Asp Pro Arg Ala Lys His Leu Arg Glu Met Ser Lys Lys Leu 
            260                 265                 270         

Thr Ser Ile Thr Gly Glu Ser Lys Trp Tyr Glu Met Ser Val Lys Ile 
        275                 280                 285             

Glu Glu Ile Val Thr Asn Glu Lys Gly Leu Leu Pro Asn Val Asp Phe 
    290                 295                 300                 

Tyr Ser Ala Ser Val Tyr His Ser Leu Gly Ile Lys His Asp Leu Phe 
305                 310                 315                 320 

Thr Pro Ile Phe Ala Val Ser Arg Met Ser Gly Trp Leu Ala His Ile 
                325                 330                 335     

Leu Glu Gln Tyr Ser Asn Asn Arg Leu Ile Arg Pro Arg Ala Glu Tyr 
            340                 345                 350         

Val Gly Pro Asn Lys Arg Gln Tyr Val Arg Leu Glu Glu Arg 
        355                 360                 365     

<210>   280
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   280
Met Ala Ala Glu Thr Thr Phe Lys Ala Gly Leu Glu Asp Val Val Ser 
                5                   10                  15      

Asn Thr Ser Glu Ile Cys Phe Leu Asp Gly Lys Gln Gly Arg Leu Leu 
            20                  25                  30          

Tyr Tyr Gly Tyr Asp Ile His Asp Leu Val Asp Gly Gly Ala Ser Phe 
        35                  40                  45              

Glu Glu Val Val Tyr Leu Leu Trp His Gly Glu Leu Pro Asn Gln Ser 
    50                  55                  60                  

Glu Leu Lys Ala Phe Thr Glu Glu Leu Ala Ser Glu Arg Ala Leu Ala 
65                  70                  75                  80  

Glu Pro Val Leu Asp Leu Leu Lys Arg Leu Pro Lys Asp Ala Asn Ala 
                85                  90                  95      

Met Ala Val Leu Arg Thr Ala Val Ser Phe Leu Gly Leu Tyr Asp Pro 
            100                 105                 110         

Asp Asp Gly Asp Glu Ser Leu Glu Ala Asn Tyr Arg Lys Ala Ala Arg 
        115                 120                 125             

Leu Val Ala Lys Ile Pro Thr Ile Val Thr Ser Tyr Glu Arg Ile Arg 
    130                 135                 140                 

Gln Gly Leu Asp Pro Val Gln Pro Asp Pro Ser Leu Ser Ala Ala Ala 
145                 150                 155                 160 

Asn Phe Phe Tyr Leu Leu Arg Gly Thr Lys Pro Ser Glu Phe Glu Glu 
                165                 170                 175     

Lys Ala Phe Asn Thr Ala Leu Ile Leu His Ala Asp His Glu Leu Asn 
            180                 185                 190         

Ala Ser Thr Phe Ser Ala Arg Val Thr Ala Gly Thr Leu Ser Asp Met 
        195                 200                 205             

Tyr Ser Ala Ile Thr Ser Ala Ile Gly Thr Leu Lys Gly Pro Leu His 
    210                 215                 220                 

Gly Gly Ala Asn Glu Gln Val Met Arg Met Leu Leu Glu Ile Gly Asp 
225                 230                 235                 240 

Pro Ser Lys Ala Ile Thr Trp Ile Asp Glu Ala Leu Ala Gln Lys Lys 
                245                 250                 255     

Lys Ile Met Gly Phe Gly His Arg Val Tyr Arg Thr Glu Asp Pro Arg 
            260                 265                 270         

Ala Thr His Leu Arg Glu Leu Ser Lys Gln Ala Gly Glu Leu Lys Gly 
        275                 280                 285             

Glu Thr Lys Trp Phe Glu Met Ser Gln Ala Ile Glu Lys His Met Leu 
    290                 295                 300                 

Glu Val Lys Gly Leu His Ala Asn Val Asp Phe Tyr Ser Ala Ser Leu 
305                 310                 315                 320 

Tyr Tyr Ser Leu Gly Ile Pro Thr His Leu Tyr Thr Pro Ile Phe Ala 
                325                 330                 335     

Cys Ser Arg Ile Ser Gly Trp Thr Ala His Val Leu Glu Gln Tyr Lys 
            340                 345                 350         

Asn Asn Arg Leu Ile Arg Pro Arg Ala Asp Tyr Val Gly Pro Thr Asp 
        355                 360                 365             

Arg Lys Phe Val Pro Leu Ser Glu Arg 
    370                 375         

<210>   281
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   281
Met Ala Ala Glu Thr Thr Phe Lys Ala Gly Leu Glu Asp Val Val Ser 
                5                   10                  15      

Asn Thr Ser Glu Ile Cys Phe Leu Asp Gly Lys Gln Gly Arg Leu Leu 
            20                  25                  30          

Tyr Tyr Gly Tyr Asp Ile His Asp Leu Val Asp Gly Gly Ala Ser Phe 
        35                  40                  45              

Glu Glu Val Val Tyr Leu Leu Trp His Gly Glu Leu Pro Asn Gln Ser 
    50                  55                  60                  

Glu Leu Lys Ala Phe Thr Glu Glu Leu Ala Ser Glu Arg Ala Leu Ala 
65                  70                  75                  80  

Glu Pro Val Leu Asp Leu Leu Lys Arg Leu Pro Lys Asp Ala Asn Ala 
                85                  90                  95      

Met Ala Val Leu Arg Thr Ala Val Ser Phe Leu Gly Leu Tyr Asp Pro 
            100                 105                 110         

Asp Asp Gly Asp Glu Ser Leu Glu Ala Asn Tyr Arg Lys Ala Ala Arg 
        115                 120                 125             

Leu Val Ala Lys Ile Pro Thr Ile Val Thr Ser Tyr Glu Arg Ile Arg 
    130                 135                 140                 

Gln Gly Leu Asp Pro Val Gln Pro Asp Pro Ser Leu Ser Ala Ala Ala 
145                 150                 155                 160 

Asn Phe Phe Tyr Leu Leu Arg Gly Thr Lys Pro Ser Glu Phe Glu Glu 
                165                 170                 175     

Lys Ala Phe Asn Thr Ala Leu Ile Leu His Ala Asp His Glu Leu Asn 
            180                 185                 190         

Ala Ser Thr Phe Ser Ala Arg Val Thr Ala Gly Thr Leu Ser Asp Met 
        195                 200                 205             

Tyr Ser Ala Ile Thr Ser Ala Ile Gly Thr Leu Lys Gly Pro Leu His 
    210                 215                 220                 

Gly Gly Ala Asn Glu Gln Val Met Arg Met Leu Leu Glu Ile Gly Asp 
225                 230                 235                 240 

Pro Ser Lys Ala Ile Thr Trp Ile Asp Glu Ala Leu Ala Gln Lys Lys 
                245                 250                 255     

Lys Ile Met Gly Phe Gly His Arg Val Tyr Arg Thr Glu Asp Pro Arg 
            260                 265                 270         

Ala Thr His Leu Arg Glu Leu Ser Lys Gln Ala Gly Glu Leu Lys Gly 
        275                 280                 285             

Glu Thr Lys Trp Phe Glu Met Ser Gln Ala Ile Glu Lys His Met Leu 
    290                 295                 300                 

Glu Val Lys Gly Leu His Ala Asn Val Asp Phe Tyr Ser Ala Ser Leu 
305                 310                 315                 320 

Tyr Tyr Ser Leu Gly Ile Pro Thr His Leu Tyr Thr Pro Ile Phe Ala 
                325                 330                 335     

Cys Ser Arg Ile Ser Gly Trp Thr Ala His Val Leu Glu Gln Tyr Lys 
            340                 345                 350         

Asn Asn Arg Leu Ile Arg Pro Arg Ala Glu Tyr Val Gly Pro Thr Asp 
        355                 360                 365             

Arg Arg Phe Val Pro Leu Ser Glu Arg 
    370                 375         

<210>   282
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   282
Met Ala Ala Glu Thr Thr Phe Lys Ala Gly Leu Glu Asp Val Val Ser 
                5                   10                  15      

Asn Thr Ser Glu Ile Cys Phe Leu Asp Gly Lys Gln Gly Arg Leu Leu 
            20                  25                  30          

Tyr Tyr Gly Tyr Asp Ile His Asp Leu Val Asp Gly Gly Ala Ser Phe 
        35                  40                  45              

Glu Glu Val Val Tyr Leu Leu Trp His Gly Glu Leu Pro Asn Gln Ser 
    50                  55                  60                  

Glu Leu Lys Ala Phe Thr Glu Glu Leu Ala Ser Glu Arg Ala Leu Ala 
65                  70                  75                  80  

Glu Pro Val Leu Asp Leu Leu Lys Arg Leu Pro Lys Asp Ala Asn Ala 
                85                  90                  95      

Met Ala Val Leu Arg Thr Ala Val Ser Phe Leu Gly Leu Tyr Asp Pro 
            100                 105                 110         

Asp Asp Gly Asp Glu Ser Leu Glu Ala Asn Tyr Arg Lys Ala Ala Arg 
        115                 120                 125             

Leu Val Ala Lys Ile Pro Thr Ile Val Thr Ser Tyr Glu Arg Ile Arg 
    130                 135                 140                 

Gln Gly Leu Asp Pro Val Gln Pro Asp Pro Ser Leu Ser Ala Ala Ala 
145                 150                 155                 160 

Asn Phe Phe Tyr Leu Leu Arg Gly Thr Lys Pro Ser Glu Phe Glu Glu 
                165                 170                 175     

Lys Ala Phe Asn Thr Ala Leu Ile Leu His Ala Asp His Glu Leu Asn 
            180                 185                 190         

Ala Ser Thr Phe Ser Ala Arg Val Thr Ala Gly Thr Leu Ser Asp Met 
        195                 200                 205             

Tyr Ser Ala Ile Thr Ser Ala Ile Gly Thr Leu Lys Gly Pro Leu His 
    210                 215                 220                 

Gly Gly Ala Asn Glu Gln Val Met Arg Met Leu Leu Glu Ile Gly Asp 
225                 230                 235                 240 

Pro Ser Lys Ala Ile Thr Trp Ile Asp Glu Ala Leu Ala Gln Lys Lys 
                245                 250                 255     

Lys Ile Met Gly Phe Gly His Arg Val Tyr Arg Thr Glu Asp Pro Arg 
            260                 265                 270         

Ala Thr His Leu Arg Glu Leu Ser Lys Gln Ala Gly Glu Leu Lys Gly 
        275                 280                 285             

Glu Thr Lys Trp Phe Glu Met Ser Gln Ala Ile Glu Lys His Met Leu 
    290                 295                 300                 

Glu Val Lys Gly Leu His Ala Asn Val Asp Phe Tyr Ser Ala Ser Leu 
305                 310                 315                 320 

Tyr Tyr Ser Leu Gly Ile Pro Thr His Leu Tyr Thr Pro Ile Phe Ala 
                325                 330                 335     

Cys Ser Arg Ile Ser Gly Trp Thr Ala His Val Leu Glu Gln Tyr Lys 
            340                 345                 350         

Asn Asn Arg Leu Ile Arg Pro Arg Ala Glu Tyr Val Gly Pro Thr Asp 
        355                 360                 365             

Lys Lys Phe Val Pro Leu Ser Glu Arg 
    370                 375         

<210>   283
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   283
Met Ala Ala Glu Thr Thr Phe Lys Ala Gly Leu Glu Asp Val Val Ser 
                5                   10                  15      

Asn Thr Ser Glu Ile Cys Phe Leu Asp Gly Lys Gln Gly Lys Leu Leu 
            20                  25                  30          

Tyr Tyr Gly Tyr Asp Ile His Asp Leu Val Asp Gly Gly Ala Ser Phe 
        35                  40                  45              

Glu Glu Val Val Tyr Leu Leu Trp His Gly Glu Leu Pro Asn Gln Ser 
    50                  55                  60                  

Glu Leu Lys Ala Phe Thr Glu Glu Leu Ala Ser Glu Arg Ala Leu Ala 
65                  70                  75                  80  

Glu Pro Val Leu Asp Leu Leu Lys Arg Leu Pro Lys Asp Ala Asn Ala 
                85                  90                  95      

Met Ala Val Leu Arg Thr Ala Val Ser Phe Leu Gly Leu Tyr Asp Pro 
            100                 105                 110         

Asp Asp Gly Asp Glu Ser Leu Glu Ala Asn Tyr Arg Lys Ala Ala Arg 
        115                 120                 125             

Leu Val Ala Lys Ile Pro Thr Ile Val Thr Ser Tyr Glu Arg Ile Arg 
    130                 135                 140                 

Gln Gly Leu Asp Pro Val Gln Pro Asp Pro Ser Leu Ser Ala Ala Ala 
145                 150                 155                 160 

Asn Phe Phe Tyr Leu Leu Arg Gly Thr Lys Pro Ser Glu Phe Glu Glu 
                165                 170                 175     

Lys Ala Phe Asn Thr Ala Leu Ile Leu His Ala Asp His Glu Leu Asn 
            180                 185                 190         

Ala Ser Thr Phe Ser Ala Arg Val Thr Ala Gly Thr Leu Ser Asp Met 
        195                 200                 205             

Tyr Ser Ala Ile Thr Ser Ala Ile Gly Thr Leu Lys Gly Pro Leu His 
    210                 215                 220                 

Gly Gly Ala Asn Glu Gln Val Met Arg Met Leu Leu Glu Ile Gly Asp 
225                 230                 235                 240 

Pro Ser Lys Ala Ile Thr Trp Ile Asp Glu Ala Leu Ala Gln Lys Lys 
                245                 250                 255     

Lys Ile Met Gly Phe Gly His Arg Val Tyr Arg Thr Glu Asp Pro Arg 
            260                 265                 270         

Ala Thr His Leu Arg Glu Leu Ser Lys Gln Ala Gly Glu Leu Lys Gly 
        275                 280                 285             

Glu Thr Lys Trp Phe Glu Met Ser Gln Ala Ile Glu Lys His Met Leu 
    290                 295                 300                 

Glu Val Lys Gly Leu His Ala Asn Val Asp Phe Tyr Ser Ala Ser Leu 
305                 310                 315                 320 

Tyr Tyr Ser Leu Gly Ile Pro Thr His Leu Tyr Thr Pro Ile Phe Ala 
                325                 330                 335     

Cys Ser Arg Ile Ser Gly Trp Thr Ala His Val Leu Glu Gln Tyr Lys 
            340                 345                 350         

Asn Asn Arg Leu Ile Arg Pro Arg Ala Glu Tyr Val Gly Pro Thr Asp 
        355                 360                 365             

Arg Lys Phe Val Pro Leu Ser Glu Arg 
    370                 375         

<210>   284
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   284
Met Ala Ala Glu Thr Thr Phe Lys Ala Gly Leu Glu Asp Val Val Ser 
                5                   10                  15      

Asn Thr Ser Glu Ile Cys Phe Leu Asp Gly Lys Gln Gly Arg Leu Leu 
            20                  25                  30          

Tyr Tyr Gly Tyr Asp Ile His Asp Leu Val Asp Gly Gly Ala Ser Phe 
        35                  40                  45              

Glu Glu Val Val Tyr Leu Leu Trp His Gly Glu Leu Pro Asn Gln Ser 
    50                  55                  60                  

Glu Leu Lys Ala Phe Thr Glu Glu Leu Ala Ser Glu Arg Ala Leu Ala 
65                  70                  75                  80  

Glu Pro Val Leu Asp Leu Leu Lys Arg Leu Pro Lys Asp Ala Asn Ala 
                85                  90                  95      

Met Ala Val Leu Arg Thr Ala Val Ser Phe Leu Gly Leu Tyr Asp Pro 
            100                 105                 110         

Asp Asp Gly Asp Glu Ser Leu Glu Ala Asn Tyr Arg Lys Ala Ala Arg 
        115                 120                 125             

Leu Val Ala Lys Ile Pro Thr Ile Val Thr Ser Tyr Glu Arg Ile Arg 
    130                 135                 140                 

Asn Gly Leu Asp Pro Val Gln Pro Asp Pro Ser Leu Ser Ala Ala Ala 
145                 150                 155                 160 

Asn Phe Phe Tyr Leu Leu Arg Gly Thr Lys Pro Ser Glu Phe Glu Glu 
                165                 170                 175     

Lys Ala Phe Asn Thr Ala Leu Ile Leu His Ala Asp His Glu Leu Asn 
            180                 185                 190         

Ala Ser Thr Phe Ser Ala Arg Val Thr Ala Gly Thr Leu Ser Asp Met 
        195                 200                 205             

Tyr Ser Ala Ile Thr Ser Ala Ile Gly Thr Leu Lys Gly Pro Leu His 
    210                 215                 220                 

Gly Gly Ala Asn Glu Gln Val Met Arg Met Leu Leu Glu Ile Gly Asp 
225                 230                 235                 240 

Pro Ser Lys Ala Ile Thr Trp Ile Asp Glu Ala Leu Ala Gln Lys Lys 
                245                 250                 255     

Lys Ile Met Gly Phe Gly His Arg Val Tyr Arg Thr Glu Asp Pro Arg 
            260                 265                 270         

Ala Thr His Leu Arg Glu Leu Ser Lys Gln Ala Gly Glu Leu Lys Gly 
        275                 280                 285             

Glu Thr Lys Trp Phe Glu Met Ser Gln Ala Ile Glu Lys His Met Leu 
    290                 295                 300                 

Glu Val Lys Gly Leu His Ala Asn Val Asp Phe Tyr Ser Ala Ser Leu 
305                 310                 315                 320 

Tyr Tyr Ser Leu Gly Ile Pro Thr His Leu Tyr Thr Pro Ile Phe Ala 
                325                 330                 335     

Cys Ser Arg Ile Ser Gly Trp Thr Ala His Val Leu Glu Gln Tyr Lys 
            340                 345                 350         

Asn Asn Arg Leu Ile Arg Pro Arg Ala Glu Tyr Val Gly Pro Thr Asp 
        355                 360                 365             

Arg Lys Phe Val Pro Leu Ser Glu Arg 
    370                 375         

<210>   285
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   285
atggcagcgg aaacgacatt caaagccggg ctggaagacg tggtctccaa cacgtctgaa       60

atctgcttct tggatgggaa acagggtcgc cttctgtact acggatatga tatccacgat      120

ctcgtcgatg gcggcgcctc gtttgaggag gtcgtgtacc ttctgtggca cggcgagctg      180

ccgaatcagt cggagctgaa agcgttcacc gaggaactcg ccagcgagcg ggcattggct      240

gaacccgtgc tcgatctctt gaaacgcctc ccgaaggacg cgaatgcgat ggccgtactt      300

cgcacggcgg tctccttcct cggtctgtat gatcccgatg acggcgatga gagcctggag      360

gcaaactacc gcaaagccgc gcgcctcgtc gcgaagattc caaccatcgt gacctcctac      420

gagcgcatcc gccaaggact ggaccccgta caaccggatc cttcgctgag cgccgctgcg      480

aacttcttct atctcctccg tggcacgaag ccttccgaat tcgaggagaa ggcattcaac      540

accgcactca ttctgcacgc agatcacgaa ttgaacgctt cgacgttctc ggcgcgcgtc      600

acggcgggca cgctgtcgga catgtattcc gccatcacgt cggccatcgg cacgcttaaa      660

ggtcctctgc acggcggcgc caatgagcag gtgatgcgca tgctgctcga aattggcgat      720

cccagcaagg ccatcacgtg gatcgacgag gcgctcgcgc agaagaagaa gatcatgggc      780

ttcggccatc gcgtgtatcg gaccgaggat ccgcgcgcga cgcaccttcg cgagctcagc      840

aagcaggcgg gcgagctgaa gggcgaaacg aaatggttcg agatgtccca ggccattgaa      900

aagcacatgc tcgaggtcaa gggcctgcac gcgaacgtgg acttctattc ggcgtcgctc      960

tactattcgc tcggcattcc gacgcacctg tacacgccca tcttcgcgtg cagccgcatc     1020

tccgggtgga cggcgcacgt gctcgagcag tacaagaaca atcgcctcat ccgcccgcgg     1080

gccgattacg tcggaccgac ggatcgcaag tttgtcccgc tcagcgagcg ctga           1134


<210>   286
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   286
atggcagcgg aaacgacatt caaagccggg ctggaagacg tggtctccaa cacgtctgaa       60

atctgcttct tggatgggaa acagggtcgc cttctgtact acggatatga tatccacgat      120

ctcgtcgatg gcggcgcctc gtttgaggag gtcgtgtacc ttctgtggca cggcgagctg      180

ccgaatcagt cggagctgaa agcgttcacc gaggaactcg ccagcgagcg ggcattggct      240

gaacccgtgc tcgatctctt gaaacgcctc ccgaaggacg cgaatgcgat ggccgtactt      300

cgcacggcgg tctccttcct cggtctgtat gatcccgatg acggcgatga gagcctggag      360

gcaaactacc gcaaagccgc gcgcctcgtc gcgaagattc caaccatcgt gacctcctac      420

gagcgcatcc gccaaggact ggaccccgta caaccggatc cttcgctgag cgccgctgcg      480

aacttcttct atctcctccg tggcacgaag ccttccgaat tcgaggagaa ggcattcaac      540

accgcactca ttctgcacgc agatcacgaa ttgaacgctt cgacgttctc ggcgcgcgtc      600

acggcgggca cgctgtcgga catgtattcc gccatcacgt cggccatcgg cacgcttaaa      660

ggtcctctgc acggcggcgc caatgagcag gtgatgcgca tgctgctcga aattggcgat      720

cccagcaagg ccatcacgtg gatcgacgag gcgctcgcgc agaagaagaa gatcatgggc      780

ttcggccatc gcgtgtatcg gaccgaggat ccgcgcgcga cgcaccttcg cgagctcagc      840

aagcaggcgg gcgagctgaa gggcgaaacg aaatggttcg agatgtccca ggccattgaa      900

aagcacatgc tcgaggtcaa gggcctgcac gcgaacgtgg acttctattc ggcgtcgctc      960

tactattcgc tcggcattcc gacgcacctg tacacgccca tcttcgcgtg cagccgcatc     1020

tccgggtgga cggcgcacgt gctcgagcag tacaagaaca atcgcctcat ccgcccgcgg     1080

gccgagtacg tcggaccgac ggatcgccgt tttgtcccgc tcagcgagcg ctga           1134


<210>   287
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   287
atggcagcgg aaacgacatt caaagccggg ctggaagacg tggtctccaa cacgtctgaa       60

atctgcttct tggatgggaa acagggtcgc cttctgtact acggatatga tatccacgat      120

ctcgtcgatg gcggcgcctc gtttgaggag gtcgtgtacc ttctgtggca cggcgagctg      180

ccgaatcagt cggagctgaa agcgttcacc gaggaactcg ccagcgagcg ggcattggct      240

gaacccgtgc tcgatctctt gaaacgcctc ccgaaggacg cgaatgcgat ggccgtactt      300

cgcacggcgg tctccttcct cggtctgtat gatcccgatg acggcgatga gagcctggag      360

gcaaactacc gcaaagccgc gcgcctcgtc gcgaagattc caaccatcgt gacctcctac      420

gagcgcatcc gccaaggact ggaccccgta caaccggatc cttcgctgag cgccgctgcg      480

aacttcttct atctcctccg tggcacgaag ccttccgaat tcgaggagaa ggcattcaac      540

accgcactca ttctgcacgc agatcacgaa ttgaacgctt cgacgttctc ggcgcgcgtc      600

acggcgggca cgctgtcgga catgtattcc gccatcacgt cggccatcgg cacgcttaaa      660

ggtcctctgc acggcggcgc caatgagcag gtgatgcgca tgctgctcga aattggcgat      720

cccagcaagg ccatcacgtg gatcgacgag gcgctcgcgc agaagaagaa gatcatgggc      780

ttcggccatc gcgtgtatcg gaccgaggat ccgcgcgcga cgcaccttcg cgagctcagc      840

aagcaggcgg gcgagctgaa gggcgaaacg aaatggttcg agatgtccca ggccattgaa      900

aagcacatgc tcgaggtcaa gggcctgcac gcgaacgtgg acttctattc ggcgtcgctc      960

tactattcgc tcggcattcc gacgcacctg tacacgccca tcttcgcgtg cagccgcatc     1020

tccgggtgga cggcgcacgt gctcgagcag tacaagaaca atcgcctcat ccgcccgcgg     1080

gccgagtacg tcggaccgac ggataaaaag tttgtcccgc tcagcgagcg ctga           1134


<210>   288
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   288
atggcagcgg aaacgacatt caaagccggg ctggaagacg tggtctccaa cacgtctgaa       60

atctgcttct tggatgggaa acagggtaaa cttctgtact acggatatga tatccacgat      120

ctcgtcgatg gcggcgcctc gtttgaggag gtcgtgtacc ttctgtggca cggcgagctg      180

ccgaatcagt cggagctgaa agcgttcacc gaggaactcg ccagcgagcg ggcattggct      240

gaacccgtgc tcgatctctt gaaacgcctc ccgaaggacg cgaatgcgat ggccgtactt      300

cgcacggcgg tctccttcct cggtctgtat gatcccgatg acggcgatga gagcctggag      360

gcaaactacc gcaaagccgc gcgcctcgtc gcgaagattc caaccatcgt gacctcctac      420

gagcgcatcc gccaaggact ggaccccgta caaccggatc cttcgctgag cgccgctgcg      480

aacttcttct atctcctccg tggcacgaag ccttccgaat tcgaggagaa ggcattcaac      540

accgcactca ttctgcacgc agatcacgaa ttgaacgctt cgacgttctc ggcgcgcgtc      600

acggcgggca cgctgtcgga catgtattcc gccatcacgt cggccatcgg cacgcttaaa      660

ggtcctctgc acggcggcgc caatgagcag gtgatgcgca tgctgctcga aattggcgat      720

cccagcaagg ccatcacgtg gatcgacgag gcgctcgcgc agaagaagaa gatcatgggc      780

ttcggccatc gcgtgtatcg gaccgaggat ccgcgcgcga cgcaccttcg cgagctcagc      840

aagcaggcgg gcgagctgaa gggcgaaacg aaatggttcg agatgtccca ggccattgaa      900

aagcacatgc tcgaggtcaa gggcctgcac gcgaacgtgg acttctattc ggcgtcgctc      960

tactattcgc tcggcattcc gacgcacctg tacacgccca tcttcgcgtg cagccgcatc     1020

tccgggtgga cggcgcacgt gctcgagcag tacaagaaca atcgcctcat ccgcccgcgg     1080

gccgagtacg tcggaccgac ggatcgcaag tttgtcccgc tcagcgagcg ctga           1134


<210>   289
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   289
atggcagcgg aaacgacatt caaagccggg ctggaagacg tggtctccaa cacgtctgaa       60

atctgcttct tggatgggaa acagggtcgc cttctgtact acggatatga tatccacgat      120

ctcgtcgatg gcggcgcctc gtttgaggag gtcgtgtacc ttctgtggca cggcgagctg      180

ccgaatcagt cggagctgaa agcgttcacc gaggaactcg ccagcgagcg ggcattggct      240

gaacccgtgc tcgatctctt gaaacgcctc ccgaaggacg cgaatgcgat ggccgtactt      300

cgcacggcgg tctccttcct cggtctgtat gatcccgatg acggcgatga gagcctggag      360

gcaaactacc gcaaagccgc gcgcctcgtc gcgaagattc caaccatcgt gacctcctac      420

gagcgcatcc gcaatggact ggaccccgta caaccggatc cttcgctgag cgccgctgcg      480

aacttcttct atctcctccg tggcacgaag ccttccgaat tcgaggagaa ggcattcaac      540

accgcactca ttctgcacgc agatcacgaa ttgaacgctt cgacgttctc ggcgcgcgtc      600

acggcgggca cgctgtcgga catgtattcc gccatcacgt cggccatcgg cacgcttaaa      660

ggtcctctgc acggcggcgc caatgagcag gtgatgcgca tgctgctcga aattggcgat      720

cccagcaagg ccatcacgtg gatcgacgag gcgctcgcgc agaagaagaa gatcatgggc      780

ttcggccatc gcgtgtatcg gaccgaggat ccgcgcgcga cgcaccttcg cgagctcagc      840

aagcaggcgg gcgagctgaa gggcgaaacg aaatggttcg agatgtccca ggccattgaa      900

aagcacatgc tcgaggtcaa gggcctgcac gcgaacgtgg acttctattc ggcgtcgctc      960

tactattcgc tcggcattcc gacgcacctg tacacgccca tcttcgcgtg cagccgcatc     1020

tccgggtgga cggcgcacgt gctcgagcag tacaagaaca atcgcctcat ccgcccgcgg     1080

gccgagtacg tcggaccgac ggatcgcaag tttgtcccgc tcagcgagcg ctga           1134


<210>   290
<211>   1007
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   290
Met Cys Phe Ala Arg Glu Val Leu Arg Gly Asn Ser Asp Cys Gly Ile 
                5                   10                  15      

His Arg Asn Arg Lys Arg Ile Gly Phe Val Leu Pro Val Tyr Ser Phe 
            20                  25                  30          

Ser Asp Thr Arg Pro Glu Phe Leu Leu Gly Ile Pro Gly Cys Pro Lys 
        35                  40                  45              

Ala Pro Gln Ala Gly Ala Pro Ser Cys Pro Val Arg Val Glu Glu Gly 
    50                  55                  60                  

Phe Thr Met Ala Asn Glu Gln Pro Gly Ser Val Gln Thr Phe Trp His 
65                  70                  75                  80  

Gln Phe Ser Gly Pro Asn Leu Ala Tyr Leu Leu Glu Gln Tyr Glu Gln 
                85                  90                  95      

Tyr Leu Ala Asp Pro Asn Ala Val Pro Glu Asp Val Arg Ser Leu Phe 
            100                 105                 110         

Ala Gln Tyr Gly Asp Pro Ala Gln Ala Val Ser Ala Ser Pro Ile Glu 
        115                 120                 125             

Thr Gln Pro Val Phe Gly Pro Gln Val Ser Ala Leu Ser Pro Arg Thr 
    130                 135                 140                 

Leu Glu Ala Ala Ala Lys Ala His Gln Leu Ala Gln Ala Ile Arg Ala 
145                 150                 155                 160 

Asn Gly His Leu Ala Ala Asp Thr Asp Pro Leu Phe Ala Pro Glu Gly 
                165                 170                 175     

Ser Pro Glu Leu Glu Ala Ser Thr Tyr Gly Leu Val Glu Ala Asp Leu 
            180                 185                 190         

Ala Ser Leu Pro Ala Ser Val Val Gly Gly Pro Ile Ala Gln Thr Ala 
        195                 200                 205             

Pro Thr Ala Leu Ala Ala Ile Glu Ala Leu Arg Lys Ala Tyr Cys Ser 
    210                 215                 220                 

Asp Leu Gly Tyr Glu Phe Ala His Leu Ser Ser Arg Glu Glu Arg Ala 
225                 230                 235                 240 

Trp Phe Glu Asp Gln Ile Glu Asn Arg Arg Phe His Gln Pro Leu Thr 
                245                 250                 255     

Leu Asp Glu Ala Lys Ala Leu Tyr Glu Leu Leu Ala Arg Ala Gln Leu 
            260                 265                 270         

Phe Glu Arg Phe Met His Lys Arg Phe Val Gly Gln Lys Arg Phe Ser 
        275                 280                 285             

Val Glu Gly Val Asp Ala Leu Val Pro Met Val Asp Ala Leu Ala Lys 
    290                 295                 300                 

Met Ala Val Asp Ala Gly Phe Asp His Val Phe Ile Gly Met Ala His 
305                 310                 315                 320 

Arg Gly Arg Leu Asn Ile Leu Ala His Val Leu Lys Lys Pro Tyr Glu 
                325                 330                 335     

Arg Ile Phe Ser Glu Phe His Ala Gly Asn Gly Met Ala Ser Asp Glu 
            340                 345                 350         

Glu Leu Ala Glu Tyr Met Leu Gly Trp Gly Gly Asp Val Lys Tyr His 
        355                 360                 365             

Met Gly Trp Thr Arg Thr Phe Glu Thr Pro Asn Gly His Lys Ala Arg 
    370                 375                 380                 

Tyr Val Leu Ser Asn Asn Pro Ser His Leu Glu Phe Val Asp Pro Val 
385                 390                 395                 400 

Val Glu Gly Met Thr Arg Ala Ala Gln Asp Asp Arg Thr Arg Pro Gly 
                405                 410                 415     

Gln Pro Ile Gln Asp Val His Lys Ala Phe Pro Ile Leu Val His Gly 
            420                 425                 430         

Asp Ala Ala Phe Thr Gly Glu Gly Val Val Ala Glu Thr Leu Asn Phe 
        435                 440                 445             

Ser Lys Ile Pro Gly Tyr Tyr Thr Gly Gly Thr Val His Ile Ile Ala 
    450                 455                 460                 

Asn Asn His Leu Gly Phe Thr Ala Asp Pro Glu Gln Gly Arg Ser Thr 
465                 470                 475                 480 

Arg Tyr Ala Ser Asp Ile Ala Lys Gly Tyr Asp Leu Pro Val Val His 
                485                 490                 495     

Val Ser Ala Asp Asn Pro Glu Ala Cys Leu Arg Ala Val Arg Leu Ala 
            500                 505                 510         

Phe Leu Tyr Arg Glu Thr Phe Gln Lys Asp Ile Val Ile Asp Leu Val 
        515                 520                 525             

Gly Tyr Arg Arg Trp Gly His Asn Glu Ser Asp Asp Pro Ala Met Thr 
    530                 535                 540                 

Gln Pro Val Met Tyr Ala Lys Ile Ala Ser His Pro Thr Val Met Glu 
545                 550                 555                 560 

Ile Tyr Ala Asn Glu Leu Val Ala Arg Gly Ala Phe Thr Ala Ala Asp 
                565                 570                 575     

Leu Gln Lys Ile Asp Gln Ala Ile Asp Glu Glu Leu Leu Gln Ala Tyr 
            580                 585                 590         

Lys Lys Tyr Pro Glu Ile His Thr Pro Ala Ala Ile Thr Asp Phe Ser 
        595                 600                 605             

Glu Pro Thr Glu Asp Ala Lys Pro Val Pro Leu Glu Glu Leu Lys Glu 
    610                 615                 620                 

Ile Asn Arg Ala Leu Leu Glu Thr Pro Pro Asp Phe Thr Val Tyr Pro 
625                 630                 635                 640 

Lys Leu Lys Arg Ile Leu Glu Arg Arg Arg Asp Ala Leu Asp Gly Gly 
                645                 650                 655     

Asp Ile Asp Trp Ala His Ala Glu Ala Leu Ala Phe Gly Thr Ile Leu 
            660                 665                 670         

Arg Ser Gly Thr Pro Ile Arg Met Ser Gly Gln Asp Ser Glu Arg Gly 
        675                 680                 685             

Thr Phe Gly Gln Arg His Leu Val Leu His Asp Ala Asn Thr Asn Ala 
    690                 695                 700                 

Arg Tyr Ala Pro Leu Gln His Leu Pro Gly Ala Lys Ala Ser Phe Val 
705                 710                 715                 720 

Val Tyr Asn Ser Pro Leu Ser Glu Thr Ala Val Ile Gly Phe Glu Tyr 
                725                 730                 735     

Gly Tyr Ser Val Glu Ala Lys Asp Ala Leu Val Leu Trp Glu Ala Gln 
            740                 745                 750         

Tyr Gly Asp Phe Ala Asn Val Gly Gln Pro Leu Phe Asp Asn Phe Ile 
        755                 760                 765             

Val Ala Ala Arg Ser Lys Trp Gly Glu Thr Ser Gly Leu Val Leu Leu 
    770                 775                 780                 

Leu Pro His Gly Phe Glu Gly Gln Ala His Glu His Ser Ser Gly Arg 
785                 790                 795                 800 

Val Glu Arg Phe Leu Gln Leu Ala Ala Arg Asn Asn Ile Val Val Ala 
                805                 810                 815     

Asn Val Thr Thr Ser Ala Gln Tyr Phe His Leu Leu Arg Arg Gln Ala 
            820                 825                 830         

Ala Arg Leu Lys Asn Pro Arg Pro Leu Val Ile Met Thr Pro Lys Ser 
        835                 840                 845             

Leu Leu Arg Asn Pro Leu Ala Ala Ser Lys Pro Glu Asp Leu Thr Asn 
    850                 855                 860                 

Gly Arg Phe Gln Pro Val Leu His Phe Ala Lys Thr Gly Glu Gly Ala 
865                 870                 875                 880 

Gln Ala Val Arg Arg Leu Ile Leu Ser Ser Gly Lys Val Gly Val Asp 
                885                 890                 895     

Leu Ala Ala Glu Met Ser Lys Arg Gly Glu Glu Ala Cys Ala His Val 
            900                 905                 910         

Ala Thr Ala Arg Val Glu Gln Leu Tyr Pro Phe Pro Ala Asp Arg Val 
        915                 920                 925             

Lys Asp Val Ile Ala Ser Tyr Pro Asn Leu Gln Glu Val Val Trp Leu 
    930                 935                 940                 

Gln Glu Glu Pro Glu Asn Gln Gly Pro Trp Asn Phe Met Arg Pro Arg 
945                 950                 955                 960 

Leu Gln Glu Leu Leu Pro Ala Ser Val Lys Leu Arg Tyr Ile Gly Arg 
                965                 970                 975     

Pro Glu Gln Gly Phe Val Ala Glu Gly Ser Pro Asp Val His Asn Arg 
            980                 985                 990         

Val Gln Ala Glu Ile Leu Ala Gln Ala Leu Ala Asn Asp Asn His 
        995                 1000                1005        

<210>   291
<211>   3024
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   291
gtgtgctttg cgcgcgaagt tttgcgcggg aattccgact gtggtataca tagaaatcgg       60

aaaaggatag ggtttgtcct acccgtctat tcattctctg acaccaggcc ggaattcctg      120

cttgggatcc ccgggtgtcc caaggcgccc caagcgggtg ctccgtcatg cccagtgcgc      180

gtggaagagg ggttcacaat ggcgaacgaa caacctggat cagtgcagac gttctggcat      240

cagttctcag ggccgaactt ggcctacctg ctcgagcagt atgagcagta tctcgcggat      300

cccaacgccg tgccggagga cgtgcgcagc ttattcgcgc aatacgggga tccggctcag      360

gcggtatctg cttcaccgat agagacacaa ccggtgttcg gacctcaggt ttccgctttg      420

tcgcctcgca cgctggaggc cgcggcgaag gcccaccaat tggctcaagc catccgcgcg      480

aacggccatc tcgcggcgga taccgatccg ctgtttgctc ccgaaggttc tcccgaactg      540

gaagcgtcga cgtacggcct tgtggaagcc gatctcgcct cattgcccgc ctcggtggtg      600

ggaggcccca tcgcgcagac tgcgccgacc gcactcgcgg ccatcgaggc gctgcggaag      660

gcgtactgca gcgacctggg ctacgagttt gcccatcttt cgagccgcga agagcgggcg      720

tggttcgagg atcagatcga aaaccgacgg ttccatcagc cgctcacctt ggacgaggcg      780

aaggcgcttt acgagctgct ggcgcgcgcg cagttgttcg agcggttcat gcacaagcgc      840

ttcgtcggcc agaagcggtt ttccgtcgaa ggtgtcgacg cgctcgttcc catggtggat      900

gcgcttgcga agatggcggt ggacgccggt ttcgatcacg tcttcatcgg catggcgcac      960

cgcggccgcc tgaatatcct cgcgcacgtg ctgaagaagc cctacgagcg catcttctcc     1020

gagttccacg ccggcaacgg catggcctcg gacgaggaac tcgcggaata catgctcggc     1080

tggggcggcg acgtaaagta ccacatgggc tggacgcgca ccttcgagac gccgaacggc     1140

cataaggcgc gctatgtgct gtccaacaac ccgagccatt tggaattcgt ggatcccgtc     1200

gtcgaaggca tgacgcgcgc ggcgcaggac gaccgcacgc ggcccgggca gcccattcag     1260

gacgtgcaca aggcgttccc cattctggtt cacggcgacg ccgcgttcac cggcgagggt     1320

gtggtcgctg agacgctcaa cttctcgaag atccccggct attacaccgg cggaacggtg     1380

cacatcatcg ccaataacca cctcggcttc accgctgacc cggagcaggg ccggtcgacg     1440

cgttacgcga gcgacattgc caagggctac gatctgccgg tcgtccacgt ttccgcggac     1500

aatccggaag cgtgtctgcg cgcggtgcgc ctcgccttcc tgtatcgcga gacgttccag     1560

aaggacatcg tgatcgatct cgtcgggtat cgccgttggg gccacaacga gtcggacgat     1620

cccgccatga cgcagccggt gatgtacgcg aagatcgcct cccatccgac cgtgatggag     1680

atctacgcaa acgagctcgt cgcgcggggc gcgttcacgg cggcggacct gcagaagatc     1740

gatcaggcca tcgacgagga actgctgcag gcgtacaaga agtacccgga gattcacacg     1800

cctgcggcca tcacggactt ctcggagccc acggaggacg caaagcccgt acccctggag     1860

gaactgaaag agatcaaccg ggcgctcttg gagacgccgc ccgacttcac ggtgtacccg     1920

aagctgaagc gcatcctgga gcggcgccgg gacgcgctcg acggaggcga catcgactgg     1980

gcgcatgccg aggccctggc gtttggaacc atcctgcgat ccggcacgcc catccgcatg     2040

tccggccagg actcggagcg cgggacgttc ggccagcgcc acctcgtgct ccacgacgcg     2100

aacaccaacg cgcgctacgc tccgctccag cacctgccgg gagccaaggc gagctttgtg     2160

gtgtacaata gcccgctttc ggagacggcc gtgatcgggt tcgaatacgg ctattcggtc     2220

gaagcgaagg acgcgctcgt tctgtgggaa gcgcagtacg gcgacttcgc caacgtcggt     2280

cagcccctgt ttgacaactt catcgtggcc gcgcgatcga agtgggggga gacctccggg     2340

ctggtgttgc ttttgccgca cgggttcgag gggcaggcgc acgagcactc gagtggccgc     2400

gtggagcgat tcctgcagct cgccgctcgc aacaacatcg tggtggcgaa cgtgacgacc     2460

tccgcgcagt acttccatct gctgcggcgc caggcggcac ggctcaaaaa cccgcgtccg     2520

ctcgtcatca tgacgccgaa gagcttgctc aggaacccgc ttgcggcctc gaagccggaa     2580

gatctgacca acggccgatt tcagccggtt ctgcacttcg ccaagacggg ggagggcgcg     2640

caggcggttc gccgcctgat tctctcgagt ggcaaggtgg gcgtcgatct cgccgcggag     2700

atgtcgaagc ggggcgagga ggcgtgcgcg cacgtcgcca ccgcgcgcgt cgagcagctg     2760

tacccgttcc cggcggatcg cgtgaaggac gtcatcgcgt cgtatcccaa cctgcaagag     2820

gtggtgtggc tccaggagga gcccgagaac caggggccgt ggaacttcat gcggccgagg     2880

ttgcaggaac ttcttccggc gtcggtgaaa ctccgttata tcggccgtcc cgagcagggc     2940

tttgtcgcgg aaggatcgcc ggacgtgcac aaccgcgtgc aggctgaaat tttggcgcag     3000

gcgttggcca acgataacca ttaa                                            3024


<210>   292
<211>   920
<212>   PRT
<213>   Chloroflexus aurantiacus J-10-fl

<400>   292
Trp Asn Gly Phe Tyr Gly Pro Asn Ala Gly Tyr Leu Ile Glu Leu Tyr 
                5                   10                  15      

Glu Arg Tyr Cys Ala Asp Pro Asn Ser Val Asp Glu Ala Thr Arg Ala 
            20                  25                  30          

Phe Phe Ala Gln Trp Ala Pro Pro Ser Asp Ser Ala Ala Pro Ala Gly 
        35                  40                  45              

Glu Ala Gly Gln Pro Pro Leu Asp Val Thr Arg Ile Val Gly Ala Ala 
    50                  55                  60                  

Arg Leu Ile Arg Tyr Ile Arg Glu Leu Gly His Leu Ala Ala Arg Ile 
65                  70                  75                  80  

Asp Pro Leu Gly Ser Asp Pro Pro Gly Asp Pro Gly Leu Glu Leu Ala 
                85                  90                  95      

Thr His Gly Val Thr Gln Ala Asp Leu Ala Ala Leu Pro Ala His Ile 
            100                 105                 110         

Val Arg Gly Pro Ile Ala Thr Gln Val Arg Asn Ala Ala Glu Gly Val 
        115                 120                 125             

Glu Arg Leu Arg Gln Ala Tyr Ser Gly Ser Ile Gly Tyr Glu Thr Asp 
    130                 135                 140                 

Gln Ile Gln Asp Tyr Leu Glu Arg Ala Trp Ile Arg Glu Ala Ala Glu 
145                 150                 155                 160 

Asp Arg Arg Phe Phe Gly Gly Leu Asp Ala Asp Arg Gln Arg Glu Leu 
                165                 170                 175     

Leu Asp Arg Leu Thr Glu Val Glu Cys Phe Glu Arg Phe Leu His Lys 
            180                 185                 190         

Thr Phe Pro Gly Gln Lys Arg Phe Ser Ile Glu Gly Cys Asp Met Leu 
        195                 200                 205             

Ile Pro Met Ile Asp Ala Ile Ile Arg Asn Ala Ala Val Asn Gly Thr 
    210                 215                 220                 

Lys Glu Val Val Ile Gly Met Ala His Arg Gly Arg Leu Asn Val Leu 
225                 230                 235                 240 

Ala His Ile Leu Gly Lys Pro Tyr Ser Met Ile Leu Thr Glu Phe His 
                245                 250                 255     

Ser Pro Asp Tyr Thr Lys Asp Thr Tyr Glu Gly Trp Thr Gly Asp Val 
            260                 265                 270         

Lys Tyr His Leu Gly Ala Arg Lys Ala Tyr Arg Glu Ser Gly Ile Ala 
        275                 280                 285             

Glu Met Pro Ile Thr Leu Ala Pro Asn Pro Ser His Leu Glu Phe Ile 
    290                 295                 300                 

Asn Pro Val Val Glu Gly Arg Ala Arg Ala Ala Gln Glu His Arg Asn 
305                 310                 315                 320 

Arg Pro Gly Phe Pro Glu Glu Asp Glu Lys Glu Ser Leu Ala Ile Leu 
                325                 330                 335     

Ile His Gly Asp Ala Ala Phe Pro Gly Gln Gly Ile Val Ala Glu Thr 
            340                 345                 350         

Leu Asn Leu Ser Arg Leu Lys Gly Tyr His Thr Gly Gly Thr Ile His 
        355                 360                 365             

Ile Ile Ile Asn Asn Gln Ile Gly Phe Thr Thr Asp Ser Asn Asp Ser 
    370                 375                 380                 

Arg Ser Thr Leu Tyr Ala Ser Asp Leu Ala Arg Gly Leu Glu Ile Pro 
385                 390                 395                 400 

Val Val His Val Asn Ala Asp Asp Val Glu Ala Cys Ile Ala Ala Ala 
                405                 410                 415     

Arg Met Ala Ser Ala Tyr Arg Glu Lys Phe Gln Lys Asp Phe Leu Ile 
            420                 425                 430         

Asp Leu Val Gly Tyr Arg Arg Trp Gly His Asn Glu Gly Asp Glu Pro 
        435                 440                 445             

Glu Phe Thr Gln Pro Lys Met Tyr Glu Arg Ile Arg Asn His Pro Thr 
    450                 455                 460                 

Val Arg Glu Ile Trp Ala Arg Glu Leu Glu Arg Arg Gly Ile Ile Thr 
465                 470                 475                 480 

Arg Glu Glu Ala Gln Ala Arg Val Asp Ala Val Met Asn Arg Leu Gln 
                485                 490                 495     

Gln Ala Phe Glu Lys Val Arg Glu Arg Gln Arg Leu Ala Ala Ser Leu 
            500                 505                 510         

Pro Pro Ala Pro Pro Pro Pro Val Gln Pro Leu Arg Arg Pro Pro Ile 
        515                 520                 525             

Phe Ala Arg Pro Val Ser Ala Lys Thr Leu Ile Glu Leu Asn Glu Ala 
    530                 535                 540                 

Leu Leu Asp Arg Pro Glu Gly Phe Thr Val His Pro Lys Leu Glu Arg 
545                 550                 555                 560 

Thr Leu Gln Arg Arg Arg Gln Ala Ile Phe Glu Glu Ser Gly Ile Asp 
                565                 570                 575     

Trp Gly His Ala Glu Ala Leu Ala Phe Ala Ser Ile Leu Ala Asp Gly 
            580                 585                 590         

Thr Pro Ile Arg Leu Thr Gly Gln Asp Ser Glu Arg Gly Thr Phe Ser 
        595                 600                 605             

His Arg His Ala Val Leu His Asp Val Val Thr Gly Glu Arg Phe Ile 
    610                 615                 620                 

Pro Leu His His Ile Pro Gln Ala Arg Ala Ser Phe Ala Val Tyr Asn 
625                 630                 635                 640 

Ser Pro Leu Ser Glu Ala Ser Val Leu Gly Phe Glu Tyr Gly Tyr Ser 
                645                 650                 655     

Cys His Ala Pro Asp Thr Leu Val Leu Trp Glu Ala Gln Phe Gly Asp 
            660                 665                 670         

Phe Ala Asn Gly Ala Gln Val Ile Ile Asp Gln Phe Ile Val Ser Gly 
        675                 680                 685             

His Ala Lys Trp Gly Gln Asn Pro Ser Leu Val Met Leu Leu Pro His 
    690                 695                 700                 

Gly Tyr Glu Gly Gln Gly Pro Glu His Ser Ser Ala Arg Leu Glu Arg 
705                 710                 715                 720 

Phe Leu Gln Leu Ala Ala Asn Asp Asn Ile Arg Val Ala Asn Cys Thr 
                725                 730                 735     

Thr Ala Ala Gln Tyr Phe His Leu Leu Arg Tyr Gln Ala Ala Ser Leu 
            740                 745                 750         

Tyr Ala Asp Pro Lys Pro Leu Ile Ile Leu Thr Pro Lys Ser Leu Leu 
        755                 760                 765             

Arg His Pro Arg Ser Ser Ser Ser Leu Arg Asp Leu Thr Asp His Arg 
    770                 775                 780                 

Phe Gln Pro Val Leu Gly Leu Gly Ala Glu Ala Pro Ala Pro Glu Gly 
785                 790                 795                 800 

Val Thr Arg Leu Ile Leu Cys Ser Gly Lys Val Ala Ile Asp Leu Leu 
                805                 810                 815     

Ser Ser Ala Glu Trp Glu Lys Thr Ala Gly Arg Val Asp Val Leu Arg 
            820                 825                 830         

Leu Glu Leu Leu Tyr Pro Phe Pro Ala Glu Glu Leu Arg Met Ala Met 
        835                 840                 845             

Gln Arg Tyr Pro Asn Leu Gln Glu Val Val Trp Leu Gln Glu Glu Pro 
    850                 855                 860                 

Gln Asn Met Gly Ala Trp Ser Phe Val Trp Pro Arg Leu Gln Gln Leu 
865                 870                 875                 880 

Leu Pro Glu Gly Val Thr Leu Arg Tyr Val Gly Arg Ala Glu Ser Ala 
                885                 890                 895     

Ser Pro Ala Glu Gly Leu His Ser Ile His Val Arg Glu Gln Ala Arg 
            900                 905                 910         

Ile Leu Arg Glu Ala Val Ala Asp 
        915                 920 

<210>   293
<211>   921
<212>   PRT
<213>   Chloroflexus aggregans DSM 9485

<400>   293
Trp Asn Gly Phe Tyr Gly Pro Asn Ala Gly Tyr Leu Leu Glu Leu Tyr 
                5                   10                  15      

Glu Arg Tyr Cys Ala Asp Pro Asn Ser Val Asp Glu Ala Thr Arg Ala 
            20                  25                  30          

Phe Phe Ala Gln Trp Thr Pro Pro Asp Glu Ile Thr Ser Ser Glu Thr 
        35                  40                  45              

Arg Asp Gly Gln Pro Pro Leu Asp Val Thr Arg Ile Val Gly Ala Ala 
    50                  55                  60                  

Arg Leu Ile Arg Tyr Ile Arg Glu Leu Gly His Leu Ala Ala Arg Ile 
65                  70                  75                  80  

Asp Pro Leu Gly Ser Asp Pro Pro Gly Asp Pro Gly Leu Glu Leu Ala 
                85                  90                  95      

Thr His Gly Val Thr Gln Ala Asp Leu Ala Ala Leu Pro Ala His Ile 
            100                 105                 110         

Val Arg Gly Pro Ile Ala Ser Gln Val Arg Asn Ala Ala Glu Gly Val 
        115                 120                 125             

Glu Arg Leu Arg Gln Ala Tyr Ser Gly Ser Ile Gly Tyr Glu Thr Asp 
    130                 135                 140                 

Gln Ile Gln Asp Tyr Arg Glu Arg Ala Trp Ile Arg Glu Ala Ala Glu 
145                 150                 155                 160 

Asp Arg Arg Phe Phe Gly Gly Leu Asp Ala Asp Arg Gln Arg Glu Leu 
                165                 170                 175     

Leu Asp Arg Leu Thr Glu Val Glu Thr Phe Glu Arg Phe Leu His Lys 
            180                 185                 190         

Thr Phe Pro Gly Gln Lys Arg Phe Ser Ile Glu Gly Cys Asp Met Leu 
        195                 200                 205             

Ile Pro Met Ile Asp Ala Ile Ile Arg Asn Ala Ala Ala Ser Gly Thr 
    210                 215                 220                 

Lys Glu Val Val Ile Gly Met Ala His Arg Gly Arg Leu Asn Val Leu 
225                 230                 235                 240 

Ala His Ile Leu Gly Lys Pro Tyr Ser Leu Ile Leu Thr Glu Phe His 
                245                 250                 255     

Ser Pro Asp Tyr Thr Lys Asp Thr Tyr Glu Gly Trp Ser Gly Asp Val 
            260                 265                 270         

Lys Tyr His Leu Gly Ala Arg Lys Ala Tyr Arg Glu Ser Gly Ile Ala 
        275                 280                 285             

Glu Met Pro Ile Thr Leu Ala Pro Asn Pro Ser His Leu Glu Phe Ile 
    290                 295                 300                 

Asn Pro Val Val Glu Gly Arg Ala Arg Ala Ala Gln Glu Arg Arg Asn 
305                 310                 315                 320 

Arg Pro Gly Phe Pro Glu Glu Asp Glu Lys Glu Ser Leu Ala Ile Leu 
                325                 330                 335     

Ile His Gly Asp Ala Ala Phe Pro Gly Gln Gly Ile Val Ala Glu Thr 
            340                 345                 350         

Leu Asn Leu Ser Arg Leu Lys Gly Tyr His Ile Gly Gly Thr Ile His 
        355                 360                 365             

Ile Ile Ile Asn Asn Gln Ile Gly Phe Thr Thr Asp Ser Ser Asp Ser 
    370                 375                 380                 

Arg Ser Thr Leu Tyr Ala Ser Asp Leu Ala Arg Gly Leu Glu Ile Pro 
385                 390                 395                 400 

Val Val His Val Asn Ala Asp Asp Val Glu Ala Cys Ile Ala Ala Ala 
                405                 410                 415     

Arg Met Ala Ser Ala Tyr Arg Glu Lys Phe Gln Lys Asp Phe Leu Ile 
            420                 425                 430         

Asp Leu Val Gly Tyr Arg Arg Trp Gly His Asn Glu Gly Asp Glu Pro 
        435                 440                 445             

Glu Phe Thr Gln Pro Lys Met Tyr Glu Arg Ile Arg Asn His Pro Thr 
    450                 455                 460                 

Val Arg Glu Ile Trp Ala Arg Glu Leu Glu Arg Arg Gly Ile Ile Thr 
465                 470                 475                 480 

Arg Glu Glu Ala Gln Ala Arg Val Asn Ala Val Met Asn Lys Leu Gln 
                485                 490                 495     

Gln Ala Phe Asp Lys Val Arg Glu Arg Gln Arg Leu Ala Ala Glu Leu 
            500                 505                 510         

Pro Pro Ala Pro Ala Pro Ala Pro Ser Leu Pro Pro Arg Arg Pro Pro 
        515                 520                 525             

Ile Phe Ala Arg Pro Val Ser Ala Lys Thr Leu Ile Glu Leu Asn Glu 
    530                 535                 540                 

Ala Leu Leu Asp Arg Pro Glu Gly Phe Thr Val His Pro Lys Leu Glu 
545                 550                 555                 560 

Arg Met Leu Gln Arg Arg Arg Gln Ala Ile Tyr Glu Glu Asn Gly Ile 
                565                 570                 575     

Asp Trp Gly His Ala Glu Ala Leu Ala Phe Ala Ser Ile Leu Ala Asp 
            580                 585                 590         

Gly Thr Pro Ile Arg Leu Thr Gly Gln Asp Ser Glu Arg Gly Thr Phe 
        595                 600                 605             

Ser His Arg His Ala Val Leu His Asp Val Val Thr Gly Glu Arg Phe 
    610                 615                 620                 

Ile Pro Leu His Ala Ile Pro Gln Ala Arg Ala Ser Phe Ala Val Tyr 
625                 630                 635                 640 

Asn Ser Pro Leu Ser Glu Ala Ser Val Leu Gly Phe Glu Tyr Gly Tyr 
                645                 650                 655     

Ser Cys His Ala Pro Asp Thr Leu Val Leu Trp Glu Ala Gln Phe Gly 
            660                 665                 670         

Asp Phe Ala Asn Gly Ala Gln Val Ile Ile Asp Gln Phe Ile Val Ser 
        675                 680                 685             

Gly His Ala Lys Trp Gly Gln Asn Pro Ser Leu Val Met Leu Leu Pro 
    690                 695                 700                 

His Gly Tyr Glu Gly Gln Gly Pro Glu His Ser Ser Ala Arg Leu Glu 
705                 710                 715                 720 

Arg Phe Leu Gln Leu Ala Ala Asn Asp Asn Ile Arg Ile Ala Asn Cys 
                725                 730                 735     

Thr Thr Ala Ala Gln Tyr Phe His Leu Leu Arg Tyr Gln Ala Thr Ser 
            740                 745                 750         

Leu Tyr Ala Asp Pro Lys Pro Leu Ile Ile Leu Thr Pro Lys Ser Leu 
        755                 760                 765             

Leu Arg His Pro Arg Ser Ser Ser Ser Leu Arg Asp Leu Thr Asp Leu 
    770                 775                 780                 

Arg Phe Gln Pro Val Leu Gly Leu Gly Ala Glu Ala Pro Leu Pro Glu 
785                 790                 795                 800 

Gly Val Thr Arg Leu Ile Leu Cys Ser Gly Lys Val Ala Ile Asp Leu 
                805                 810                 815     

Ile Ser Ser Ala Glu Trp Glu Lys Thr Ala Gly Arg Ala Asp Leu Leu 
            820                 825                 830         

Arg Leu Glu Leu Leu Tyr Pro Phe Pro Ala Glu Glu Val Gln Ala Ala 
        835                 840                 845             

Ile Arg Arg Tyr Pro Asn Leu Arg Glu Val Val Trp Leu Gln Glu Glu 
    850                 855                 860                 

Pro Gln Asn Met Gly Ala Trp Thr Phe Val Trp Pro Arg Leu Gln Thr 
865                 870                 875                 880 

Leu Leu Pro Thr Gly Val Thr Leu Arg Tyr Val Gly Arg Ala Glu Ser 
                885                 890                 895     

Ser Ser Pro Ala Glu Gly Leu His Ser Ile His Val Arg Glu Gln Ala 
            900                 905                 910         

Arg Ile Leu Arg Glu Ala Val Ala Asn 
        915                 920     

<210>   294
<211>   917
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   294
Gln Phe Tyr Gly Pro Asn Leu Gly Tyr Val Leu Glu Leu Tyr Glu Arg 
                5                   10                  15      

Tyr Arg Glu Asp Pro Gly Ser Val Asp Glu Glu Thr Arg Arg Phe Phe 
            20                  25                  30          

Glu Arg Trp Ser Pro Pro Arg Ile Glu Val Asp Gly Arg Val Ala Gly 
        35                  40                  45              

Ala Ala Leu Glu Ala Glu Lys Tyr Val Gly Ala Ala Lys Tyr Ile Arg 
    50                  55                  60                  

Ser Ile Arg Asp Phe Gly His Ser Ala Ala Arg Leu Asp Pro Leu Gly 
65                  70                  75                  80  

Gly Glu Pro Pro Gly Asp Pro Ala Leu Asp Pro Ala Phe His Gly Ile 
                85                  90                  95      

Thr Glu Glu Asp Leu Glu Arg Met Pro Ser Ser Ile Val Gly Gly Pro 
            100                 105                 110         

Ile Ala Glu Arg Thr Ser Asn Ala Arg Glu Ala Val Glu Glu Leu Lys 
        115                 120                 125             

Arg Ile Tyr Cys Lys Thr Thr Gly Tyr Asp Phe Gly His Ile Ala His 
    130                 135                 140                 

Leu Pro Glu Glu Arg Phe Trp Leu Arg Asp Ala Val Glu Ser Glu Gln 
145                 150                 155                 160 

Phe Tyr Gln Arg Leu Glu Gly Glu Ala Ala Arg Arg Leu Leu Arg Arg 
                165                 170                 175     

Leu Thr Arg Val Asp Thr Phe Glu Lys Phe Leu His Arg Thr Phe Leu 
            180                 185                 190         

Gly Gln Lys Arg Phe Ser Val Glu Gly Asn Asp Met Val Val Pro Met 
        195                 200                 205             

Leu Asp Arg Leu Ile Arg His Ala Ala Asp Ala Gly Thr Pro Glu Val 
    210                 215                 220                 

Val Met Gly Met Ala His Arg Gly Arg Leu Asn Val Leu Ala His Val 
225                 230                 235                 240 

Leu Asn Lys Pro Tyr Ala Lys Ile Phe Gly Glu Phe Gln Gln Pro Glu 
                245                 250                 255     

Arg Gly Glu Gln Ser Ser Val Ser Glu Met Ser Gly Glu Gly Trp Val 
            260                 265                 270         

Gly Asp Val Lys Tyr His Leu Gly Val Arg Asn Phe His Leu Glu Glu 
        275                 280                 285             

Gly Gln Glu Asp Ala Lys Val Leu Ile Asn Leu Ala Pro Asn Pro Ser 
    290                 295                 300                 

His Leu Glu His Val Asn Pro Val Val Ser Gly Met Thr Arg Ala Ala 
305                 310                 315                 320 

Gln Glu Arg Arg Asp Glu Ala Gly Pro Pro Arg Gln Asp Val Asp Ala 
                325                 330                 335     

Ala Leu Ser Ile Val Leu His Gly Asp Ala Ala Phe Pro Gly Glu Gly 
            340                 345                 350         

Val Ala Ala Glu Thr Leu Asn Leu Tyr Arg Leu Pro Gly Tyr Arg Val 
        355                 360                 365             

Gly Gly Thr Ile His Ile Ile Thr Asn Asn Gln Leu Gly Phe Thr Thr 
    370                 375                 380                 

Glu Lys Glu Asp Ala Arg Ser Thr Thr Tyr Ala Ser Asp Leu Ala Lys 
385                 390                 395                 400 

Gly Tyr Glu Ile Pro Val Val His Val Asn Ala Asp Asp Pro Glu Ala 
                405                 410                 415     

Cys Leu Ala Ala Val Ser Leu Ala Tyr Ala Tyr Arg Gln Arg Phe His 
            420                 425                 430         

Lys Asp Phe Met Ile Asp Leu Ile Gly Tyr Arg Arg Tyr Gly His Asn 
        435                 440                 445             

Glu Gly Asp Glu Pro Val Tyr Thr Gln Pro Val Met Tyr Glu Lys Ile 
    450                 455                 460                 

Arg Asn His Pro Thr Val Arg Glu Ile Trp Ala Arg Thr Leu Glu Glu 
465                 470                 475                 480 

Arg Gly Val Ile Ser Glu Gly Glu Ala Glu Lys Met Ala Glu Glu Met 
                485                 490                 495     

Phe Ala Arg Met Gln Glu Ile His Lys Asn Pro Ser Glu Gln Leu Thr 
            500                 505                 510         

Glu Glu Asp Phe Asp Thr Glu Glu Pro His Thr Pro Leu Val Asp Ile 
        515                 520                 525             

Pro Glu Thr Ala Val Glu Ala Ser Arg Leu Glu Ala Leu Asn Arg Ala 
    530                 535                 540                 

Met Leu Glu Arg Pro Glu Gly Phe Ser Pro Asn Arg Lys Leu Glu Arg 
545                 550                 555                 560 

Leu Phe Gln Lys Asn Arg Gly Ser Leu Glu Arg Ile Asp Trp Ala His 
                565                 570                 575     

Ala Glu Ala Leu Ala Phe Ala Ser Leu Leu Glu Asp Gly Ile Pro Ile 
            580                 585                 590         

Arg Leu Thr Gly Gln Asp Ser Glu Arg Gly Thr Phe Ser Gln Arg His 
        595                 600                 605             

Ala Val Leu His Asp Glu Lys Thr Gly Glu Glu Tyr Val Pro Leu Gln 
    610                 615                 620                 

Asn Ile Pro Gln Ala Arg Ala Ser Phe Asp Ile His Asn Ser Pro Leu 
625                 630                 635                 640 

Ser Glu Met Ala Val Met Gly Phe Glu Tyr Gly Tyr Ser Val Asn Ala 
                645                 650                 655     

Pro Asp Ala Leu Thr Leu Trp Glu Ala Gln Tyr Gly Asp Phe Ala Asn 
            660                 665                 670         

Val Gly Gln Pro Ile Ile Asp Gln Phe Ile Val Ser Gly Gln Ala Lys 
        675                 680                 685             

Trp Gly Gln Val Ser Asn Leu Val Leu Leu Leu Pro His Gly Tyr Glu 
    690                 695                 700                 

Gly Gln Gly Pro Glu His Ser Ser Ala Arg Leu Glu Arg Phe Leu Gln 
705                 710                 715                 720 

Leu Ala Ala Gly Glu Asn Ile Arg Val Ala Asn Pro Thr Thr Ala Ala 
                725                 730                 735     

Gln Tyr Phe His Leu Leu Arg Ala Gln Ala Ile Leu Lys Asp His Lys 
            740                 745                 750         

Arg Pro Leu Val Leu Met Thr Pro Lys Ser Leu Leu Arg His Pro Met 
        755                 760                 765             

Ala Ala Ser Gly Leu Gln Glu Leu Ala Glu Gly Arg Phe His Pro Val 
    770                 775                 780                 

Leu Asp Asp Glu Glu Ala Arg Glu Arg Ala Gly Ser Val Glu Arg Leu 
785                 790                 795                 800 

Ile Leu Cys Ser Gly Lys Ile Tyr Thr Glu Leu Val Gly Ser Asp Phe 
                805                 810                 815     

Arg Glu Glu Ala Glu Glu Val Ala Ile Ala Arg Val Glu Leu Leu Tyr 
            820                 825                 830         

Pro Phe Pro Glu Gly Gln Ile Arg Glu Val Ile Ala Gly Tyr Pro Asn 
        835                 840                 845             

Leu Arg Glu Leu Val Trp Val Gln Glu Glu Pro Lys Asn Met Gly Ala 
    850                 855                 860                 

Trp Phe Phe Met Glu Pro Arg Leu Arg Glu Ile Thr Gly Gly Glu Leu 
865                 870                 875                 880 

Pro Ile Arg Tyr Val Gly Lys Pro Ala Arg Pro Ser Pro Ala Gln Gly 
                885                 890                 895     

Ser Val Ser Phe His Arg Arg Glu His Ala Gln Ile Val Arg Glu Ala 
            900                 905                 910         

Phe Arg Arg Asp Ser 
        915         

<210>   295
<211>   936
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   295
Trp Ser Gln Phe Tyr Gly Pro Asn Leu Gly Tyr Val Ile Glu Met Tyr 
                5                   10                  15      

Glu Gln Tyr Leu Asp Asp Pro Asn Ser Ile Asp Pro Glu Leu Lys Gln 
            20                  25                  30          

Leu Phe Glu Gln Trp Gly Ala Pro Val Leu Glu Glu Pro Val Ser Pro 
        35                  40                  45              

Ala Asp Asp Glu Thr Ala Lys Thr His Gln Thr Phe Arg Leu Pro Glu 
    50                  55                  60                  

Thr Pro Thr Ile Phe Ser Lys Leu Val Ala Ala Val Lys Leu Ala Asp 
65                  70                  75                  80  

Ser Ile Arg His Tyr Gly His Leu Val Ala Asp Thr Asn Pro Leu Val 
                85                  90                  95      

Lys Lys Glu Lys Lys Leu Arg Arg Leu Glu Leu Asp Glu Tyr Asp Leu 
            100                 105                 110         

Thr Glu Glu Asp Leu Lys Arg Ile Pro Val Ala Phe Leu Cys Pro His 
        115                 120                 125             

Ala Pro Ala His Val Lys Asn Gly Trp Asp Ala Ile Leu His Leu Arg 
    130                 135                 140                 

Lys Ile Tyr Thr Asp Lys Ile Ala Phe Glu Phe Ser Gln Val His Asn 
145                 150                 155                 160 

Leu Glu Glu Arg Asn Trp Leu Ile Gln Gln Ile Glu Ser Gly Ala Tyr 
                165                 170                 175     

Tyr Pro Ser Leu Ala Asn Lys Glu Arg Val Ala Leu Leu Arg Arg Leu 
            180                 185                 190         

Thr Glu Val Glu Gly Phe Glu Lys Phe Ile His Arg Thr Tyr Val Gly 
        195                 200                 205             

Gln Lys Arg Phe Ser Ile Glu Gly Leu Asp Ser Met Val Pro Leu Leu 
    210                 215                 220                 

Asp Glu Leu Val Arg Gln Ala Ile Glu His Glu Ile Asp Ala Val Asn 
225                 230                 235                 240 

Ile Gly Met Ala His Arg Gly Arg Leu Asn Val Leu Ala His Val Leu 
                245                 250                 255     

Gly Lys Pro Tyr Glu Met Ile Phe Ala Glu Phe Gln His Ala Glu Ser 
            260                 265                 270         

Lys Asn Phe Ile Pro Ser Glu Gly Ser Val Ala Ile Thr Tyr Gly Trp 
        275                 280                 285             

Thr Gly Asp Val Lys Tyr His Leu Gly Ala Ala Arg Arg Leu Arg Asn 
    290                 295                 300                 

Gln Ser Ala His Thr Met Arg Ile Thr Leu Ala Asn Asn Pro Ser His 
305                 310                 315                 320 

Leu Glu Val Val Asn Pro Val Val Leu Gly Tyr Thr Arg Ala Ala Gln 
                325                 330                 335     

Glu Asp Arg Thr Lys Pro Gly Val Pro Val Gln Asn Thr Asp Ala Ser 
            340                 345                 350         

Phe Ala Ile Leu Ile His Gly Asp Ala Ala Phe Pro Gly Gln Gly Ile 
        355                 360                 365             

Val Ala Glu Thr Leu Asn Leu Ser Gln Leu Arg Gly Tyr Thr Thr Gly 
    370                 375                 380                 

Gly Thr Ile His Ile Ile Ala Asn Asn Met Ile Gly Phe Thr Thr Glu 
385                 390                 395                 400 

Ser Tyr Asp Ser Arg Ser Thr Thr Tyr Ala Ser Asp Met Ala Lys Gly 
                405                 410                 415     

Phe Glu Val Pro Ile Val His Val Asn Ala Asp Asp Pro Glu Ala Cys 
            420                 425                 430         

Leu Ala Ala Ala Cys Leu Ala Phe Ala Tyr Arg Gln Arg Phe Lys Lys 
        435                 440                 445             

Asp Phe Val Ile Asp Leu Ile Gly Tyr Arg Arg Phe Gly His Asn Glu 
    450                 455                 460                 

Met Asp Glu Pro Met Ala Thr Asn Pro Thr Met Tyr Ala Ile Ile Asn 
465                 470                 475                 480 

Gln His Pro Thr Val Arg Lys Leu Tyr Ala Gln Lys Leu Met Glu Lys 
                485                 490                 495     

Gly Ile Ile Thr Glu Arg Glu Val Asp Glu Met Glu Gln Glu Val Ala 
            500                 505                 510         

Glu Arg Leu Lys Ile Ala Tyr Glu Arg Val Pro Lys Asn Glu Asp Glu 
        515                 520                 525             

Leu Asp Phe Ile Met Asp Pro Pro Lys Pro Val Val Asp Arg Leu Pro 
    530                 535                 540                 

Glu Val Lys Thr Ser Val Ala Lys Asp Val Leu His Arg Val Asn Glu 
545                 550                 555                 560 

Glu Leu Leu Gln Phe Pro Asp Gly Phe Asn Val Phe Asn Lys Leu Glu 
                565                 570                 575     

Arg Ile Leu Lys Arg Arg Ser Gly Val Phe Ala Gln Asn Gly Lys Val 
            580                 585                 590         

Asp Trp Ala His Ala Glu Ile Leu Ala Phe Ala Thr Ile Leu Gln Asp 
        595                 600                 605             

Gly Val Pro Ile Arg Leu Thr Gly Gln Asp Ser Gln Arg Gly Thr Phe 
    610                 615                 620                 

Ala Gln Arg His Leu Val Leu His Asp Val Lys Thr Gly Glu Glu Tyr 
625                 630                 635                 640 

Val Pro Leu His His Ile Ser Gly Ala Lys Ala Ser Phe Val Val Tyr 
                645                 650                 655     

Asn Ser Pro Leu Thr Glu Ala Ala Val Leu Gly Tyr Glu Tyr Gly Tyr 
            660                 665                 670         

Asn Val Tyr Ala Pro Glu Thr Leu Val Leu Trp Glu Ala Gln Phe Gly 
        675                 680                 685             

Asp Phe Ala Asn Met Ala Gln Val Met Phe Asp Gln Phe Ile Ser Ser 
    690                 695                 700                 

Gly Arg Ala Lys Trp Gly Gln Lys Ser Gly Leu Val Met Leu Leu Pro 
705                 710                 715                 720 

His Gly Tyr Glu Gly Gln Gly Pro Glu His Ser Ser Gly Arg Val Glu 
                725                 730                 735     

Arg Phe Leu Gln Leu Ala Ala Glu Asn Asn Trp Thr Val Ala Asn Leu 
            740                 745                 750         

Ser Thr Ala Ala Gln Tyr Phe His Ile Leu Arg Arg Gln Ala Ala Leu 
        755                 760                 765             

Leu Thr Arg Glu Glu Val Arg Pro Leu Ile Ile Met Thr Pro Lys Ser 
    770                 775                 780                 

Leu Leu Arg His Pro Leu Ala Ala Ser Asp Ala Glu Val Phe Val Asp 
785                 790                 795                 800 

Gly Ala Phe Ser Pro Val Leu Glu Gln Pro Gly Leu Gly Ala Asp Ala 
                805                 810                 815     

Gly Lys Val Glu Arg Ile Val Phe Gly Thr Gly Lys Leu Met Ile Asp 
            820                 825                 830         

Leu Ala Glu Gln Ile Gly Lys Met Glu Ser Leu Asp Trp Leu His Ile 
        835                 840                 845             

Val Arg Ile Glu Glu Leu Tyr Pro Phe Pro Glu Glu Ala Val Lys Asp 
    850                 855                 860                 

Ile Ile Ala Arg Tyr Pro Asn Val Lys Glu Leu Val Trp Val Gln Glu 
865                 870                 875                 880 

Glu Pro Lys Asn Met Gly Ala Trp Leu Tyr Met Glu Pro Arg Leu Arg 
                885                 890                 895     

Ala Leu Ala Pro Glu Gly Val Asp Val Ser Tyr Ile Gly Arg Arg Arg 
            900                 905                 910         

Arg Ala Ser Pro Ala Glu Gly Asp Pro Val Val His Arg Lys Glu Gln 
        915                 920                 925             

Glu Arg Ile Ile Arg Cys Ala Leu 
    930                 935     

<210>   296
<211>   915
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   296
Asp Pro Asp Ser Val Asp Pro Glu Leu Lys Gln Leu Phe Glu Gln Trp 
                5                   10                  15      

Gly Ala Pro Val Val Glu Glu Pro Val Ser Pro Ala Asp Pro Glu Ala 
            20                  25                  30          

Thr Gln Thr His Gln Thr Phe Arg Leu Pro Glu Thr Pro Thr Val Phe 
        35                  40                  45              

Ser Lys Leu Val Ala Ala Val Lys Leu Ala Asp Ser Ile Arg His Tyr 
    50                  55                  60                  

Gly His Leu Ala Ala Asp Thr Asn Pro Ile Val Lys Lys Glu Lys Lys 
65                  70                  75                  80  

Leu Arg Arg Leu Glu Leu Asp Glu Tyr Asp Leu Thr Glu Glu Asp Leu 
                85                  90                  95      

Lys Arg Ile Pro Val Ala Phe Leu Cys Pro His Ala Pro Ala His Val 
            100                 105                 110         

Lys Asn Gly Trp Asp Ala Ile Leu His Leu Arg Lys Ile Tyr Thr Asp 
        115                 120                 125             

Lys Ile Ala Phe Glu Phe Ser Gln Val His Asn Leu Glu Glu Arg Asn 
    130                 135                 140                 

Trp Leu Ile Gln Gln Ile Glu Ser Gly Ala Tyr Tyr Pro Ser Leu Ala 
145                 150                 155                 160 

Asn Lys Glu Arg Val Ala Leu Leu Arg Arg Leu Thr Glu Val Glu Gly 
                165                 170                 175     

Phe Glu Lys Phe Ile His Arg Thr Tyr Val Gly Gln Lys Arg Phe Ser 
            180                 185                 190         

Ile Glu Gly Leu Asp Ser Met Val Pro Leu Leu Asp Glu Leu Val Arg 
        195                 200                 205             

Gln Ala Ile Glu His Glu Ile Asp Ala Val Asn Ile Gly Met Ala His 
    210                 215                 220                 

Arg Gly Arg Leu Asn Val Leu Ala His Val Leu Gly Lys Pro Tyr Glu 
225                 230                 235                 240 

Met Ile Phe Ala Glu Phe Gln His Ala Glu Ser Lys Asn Phe Ile Pro 
                245                 250                 255     

Ser Glu Gly Ala Val Ala Ile Thr Tyr Gly Trp Thr Gly Asp Val Lys 
            260                 265                 270         

Tyr His Leu Gly Ala Ala Arg Arg Leu Arg Asn Lys Ser Ala His Thr 
        275                 280                 285             

Met Arg Ile Thr Leu Ala Asn Asn Pro Ser His Leu Glu Val Val Asn 
    290                 295                 300                 

Pro Val Val Leu Gly Tyr Thr Arg Ala Ala Gln Glu Asp Arg Thr Lys 
305                 310                 315                 320 

Pro Gly Val Pro Glu Gln Lys Val Asp Ala Ser Phe Ala Ile Leu Ile 
                325                 330                 335     

His Gly Asp Ala Ala Phe Pro Gly Gln Gly Val Val Ala Glu Thr Leu 
            340                 345                 350         

Asn Leu Ser Gln Leu Arg Gly Tyr Thr Thr Gly Gly Ala Ile His Ile 
        355                 360                 365             

Ile Ala Asn Asn Met Ile Gly Phe Thr Thr Glu Ser Tyr Asp Ser Arg 
    370                 375                 380                 

Ser Thr Thr Tyr Ala Ser Asp Met Ala Lys Gly Phe Glu Val Pro Ile 
385                 390                 395                 400 

Val His Val Asn Ala Asp Asp Pro Glu Ala Cys Leu Ala Ala Ala Ser 
                405                 410                 415     

Leu Ala Phe Ala Tyr Arg Gln Arg Phe Lys Lys Asp Phe Val Ile Asp 
            420                 425                 430         

Leu Ile Gly Tyr Arg Arg Phe Gly His Asn Glu Met Asp Glu Pro Met 
        435                 440                 445             

Ala Thr Asn Pro Leu Met Tyr Ser Ile Ile His Gln His Pro Thr Val 
    450                 455                 460                 

Arg Gln Leu Tyr Ala Gln Lys Leu Ile Asp Lys Gly Ile Ile Ala Glu 
465                 470                 475                 480 

Arg Glu Val Glu Glu Met Glu Gln Glu Val Ala Glu Arg Leu Lys Ile 
                485                 490                 495     

Ala Tyr Glu Arg Val Pro Lys Asn Glu Glu Glu Leu Asp Phe Ile Met 
            500                 505                 510         

Asp Pro Pro Lys Pro Val Val Asp Arg Leu Pro Glu Val Lys Thr Gly 
        515                 520                 525             

Val Ala Lys Asp Val Leu His Arg Ile Asn Glu Glu Leu Leu Glu Phe 
    530                 535                 540                 

Pro Ala Asp Phe His Val Phe Asn Lys Leu Glu Arg Ile Leu Lys Arg 
545                 550                 555                 560 

Arg Ser Asn Val Phe Ala Gln Asn Gly Lys Ile Asp Trp Ala His Ala 
                565                 570                 575     

Glu Thr Leu Ala Phe Ala Thr Ile Leu Gln Asp Gly Val Pro Ile Arg 
            580                 585                 590         

Leu Thr Gly Gln Asp Ser Gln Arg Gly Thr Phe Ala Gln Arg His Leu 
        595                 600                 605             

Val Leu His Asp Val Lys Thr Gly Lys Glu Tyr Val Pro Leu His His 
    610                 615                 620                 

Ile Ser Gly Ala Lys Ala Ser Phe Val Val Tyr Asn Ser Pro Leu Thr 
625                 630                 635                 640 

Glu Ala Ala Val Leu Gly Tyr Glu Tyr Gly Tyr Asn Val Tyr Ala Pro 
                645                 650                 655     

Glu Thr Leu Val Leu Trp Glu Ala Gln Phe Gly Asp Phe Ala Asn Met 
            660                 665                 670         

Ala Gln Val Met Phe Asp Gln Phe Ile Ser Ser Gly Arg Ala Lys Trp 
        675                 680                 685             

Gly Gln Lys Ser Gly Leu Val Met Leu Leu Pro His Gly Tyr Glu Gly 
    690                 695                 700                 

Gln Gly Pro Glu His Ser Ser Gly Arg Ile Glu Arg Phe Leu Gln Leu 
705                 710                 715                 720 

Ala Ala Glu Asn Asn Trp Thr Val Ala Asn Leu Ser Thr Ala Ala Gln 
                725                 730                 735     

Tyr Phe His Ile Leu Arg Arg Gln Ala Ala Leu Leu Lys Lys Glu Glu 
            740                 745                 750         

Val Arg Pro Leu Val Leu Met Thr Pro Lys Ser Leu Leu Arg His Pro 
        755                 760                 765             

Leu Ala Ser Ser Glu Ala Glu Ala Leu Val Gln Gly Ala Phe Ser Pro 
    770                 775                 780                 

Val Leu Glu Gln Pro Gly Leu Gly Val Asp Ala Ser Lys Val Glu Arg 
785                 790                 795                 800 

Ile Val Phe Gly Thr Gly Lys Leu Met Ile Asp Leu Ala Glu Gln Ile 
                805                 810                 815     

Gly Lys Met Asp Gly Leu Asp Trp Leu His Val Val Arg Val Glu Glu 
            820                 825                 830         

Leu Tyr Pro Phe Pro Glu Glu Ala Val Gln Ala Ile Ile Ala Arg Tyr 
        835                 840                 845             

Pro Asn Val Lys Glu Leu Val Trp Val Gln Glu Glu Pro Lys Asn Met 
    850                 855                 860                 

Gly Ala Trp Met Tyr Met Glu Pro Arg Leu Arg Ala Ile Ala Pro Glu 
865                 870                 875                 880 

Gly Val Asp Val Ser Tyr Ile Gly Arg Arg Arg Arg Ala Ser Pro Ala 
                885                 890                 895     

Glu Gly Asp Pro Val Val His Arg Lys Glu Gln Glu Arg Ile Ile Arg 
            900                 905                 910         

Cys Ala Leu 
        915 

<210>   297
<211>   1007
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   297
Met Cys Phe Ala Arg Glu Val Leu Arg Gly Asn Ser Asp Cys Gly Ile 
                5                   10                  15      

His Arg Asn Arg Lys Arg Ile Gly Phe Val Leu Pro Val Tyr Ser Phe 
            20                  25                  30          

Ser Asp Thr Arg Pro Glu Phe Leu Leu Gly Ile Pro Gly Cys Pro Lys 
        35                  40                  45              

Ala Pro Gln Ala Gly Ala Pro Ser Cys Pro Val Arg Val Glu Glu Gly 
    50                  55                  60                  

Phe Thr Met Ala Asn Glu Gln Pro Gly Ser Val Gln Thr Phe Trp His 
65                  70                  75                  80  

Gln Phe Ser Gly Pro Asn Leu Ala Tyr Leu Leu Glu Gln Tyr Glu Gln 
                85                  90                  95      

Tyr Leu Ala Asp Pro Asn Ala Val Pro Glu Asp Val Arg Ser Leu Phe 
            100                 105                 110         

Ala Gln Tyr Gly Asp Pro Ala Gln Ala Val Ser Ala Ser Pro Ile Glu 
        115                 120                 125             

Thr Gln Pro Val Phe Gly Pro Gln Val Ser Ala Leu Ser Pro Arg Thr 
    130                 135                 140                 

Leu Asp Ala Ala Ala Lys Ala His Gln Leu Ala Gln Ala Ile Arg Ala 
145                 150                 155                 160 

Asn Gly His Leu Ala Ala Asp Thr Asp Pro Leu Phe Ala Pro Glu Gly 
                165                 170                 175     

Ser Pro Glu Leu Glu Ala Ser Thr Tyr Gly Leu Val Glu Ala Asp Leu 
            180                 185                 190         

Ala Ser Leu Pro Ala Ser Val Val Gly Gly Pro Ile Ala Gln Thr Ala 
        195                 200                 205             

Pro Thr Ala Leu Ala Ala Ile Glu Ala Leu Arg Lys Ala Tyr Cys Ser 
    210                 215                 220                 

Asp Leu Gly Tyr Glu Phe Ala His Leu Ser Ser Arg Glu Glu Arg Ala 
225                 230                 235                 240 

Trp Phe Glu Asp Gln Ile Glu Asn Arg Arg Phe His Gln Pro Leu Thr 
                245                 250                 255     

Leu Asp Glu Ala Lys Ala Leu Tyr Glu Leu Leu Ala Arg Ala Gln Leu 
            260                 265                 270         

Phe Glu Arg Phe Met His Lys Arg Phe Val Gly Gln Lys Arg Phe Ser 
        275                 280                 285             

Val Glu Gly Val Asp Ala Leu Val Pro Met Val Asp Ala Leu Ala Lys 
    290                 295                 300                 

Met Ala Val Asp Ala Gly Phe Asp His Val Phe Ile Gly Met Ala His 
305                 310                 315                 320 

Arg Gly Arg Leu Asn Ile Leu Ala His Val Leu Lys Lys Pro Tyr Glu 
                325                 330                 335     

Arg Ile Phe Ser Glu Phe His Ala Gly Asn Gly Met Ala Ser Asp Glu 
            340                 345                 350         

Glu Leu Ala Glu Tyr Met Leu Gly Trp Gly Gly Asp Val Lys Tyr His 
        355                 360                 365             

Met Gly Trp Thr Arg Thr Phe Glu Thr Pro Asn Gly His Lys Ala Arg 
    370                 375                 380                 

Tyr Val Leu Ser Asn Asn Pro Ser His Leu Glu Phe Val Asp Pro Val 
385                 390                 395                 400 

Val Glu Gly Met Thr Arg Ala Ala Gln Asp Asp Arg Thr Arg Pro Gly 
                405                 410                 415     

Gln Pro Ile Gln Asp Val His Lys Ala Phe Pro Ile Leu Val His Gly 
            420                 425                 430         

Asp Ala Ala Phe Thr Gly Glu Gly Val Val Ala Glu Thr Leu Asn Phe 
        435                 440                 445             

Ser Lys Ile Pro Gly Tyr Tyr Thr Gly Gly Thr Val His Ile Ile Ala 
    450                 455                 460                 

Asn Asn His Leu Gly Phe Thr Ala Asp Pro Glu Gln Gly Arg Ser Thr 
465                 470                 475                 480 

Arg Tyr Ala Ser Asp Ile Ala Lys Gly Tyr Asp Leu Pro Val Val His 
                485                 490                 495     

Val Ser Ala Asp Asn Pro Glu Ala Cys Leu Arg Ala Val Arg Leu Ala 
            500                 505                 510         

Phe Leu Tyr Arg Glu Thr Phe Gln Lys Asp Ile Val Ile Asp Leu Val 
        515                 520                 525             

Gly Tyr Arg Arg Trp Gly His Asn Glu Ser Asp Asp Pro Ala Met Thr 
    530                 535                 540                 

Gln Pro Val Met Tyr Ala Lys Ile Ala Ser His Pro Thr Val Met Glu 
545                 550                 555                 560 

Ile Tyr Ala Asn Glu Leu Val Ala Arg Gly Ala Phe Thr Ala Ala Asp 
                565                 570                 575     

Leu Gln Lys Ile Asp Gln Ala Ile Asp Glu Glu Leu Leu Gln Ala Tyr 
            580                 585                 590         

Lys Lys Tyr Pro Glu Ile His Thr Pro Ala Ala Ile Thr Asp Phe Ser 
        595                 600                 605             

Glu Pro Thr Glu Asp Ala Lys Pro Val Pro Leu Glu Glu Leu Lys Glu 
    610                 615                 620                 

Ile Asn Arg Ala Leu Leu Glu Thr Pro Pro Asp Phe Thr Val Tyr Pro 
625                 630                 635                 640 

Lys Leu Lys Arg Ile Leu Glu Arg Arg Arg Asp Ala Leu Asp Gly Gly 
                645                 650                 655     

Asp Ile Asp Trp Ala His Ala Glu Ala Leu Ala Phe Gly Thr Ile Leu 
            660                 665                 670         

Arg Ser Gly Thr Pro Ile Arg Met Ser Gly Gln Asp Ser Glu Arg Gly 
        675                 680                 685             

Thr Phe Gly Gln Arg His Leu Val Leu His Asp Ala Asn Thr Asn Ala 
    690                 695                 700                 

Arg Tyr Ala Pro Leu Gln His Leu Pro Gly Ala Lys Ala Ser Phe Val 
705                 710                 715                 720 

Val Tyr Asn Ser Pro Leu Ser Glu Thr Ala Val Ile Gly Phe Glu Tyr 
                725                 730                 735     

Gly Tyr Ser Val Glu Ala Lys Asp Ala Leu Val Leu Trp Glu Ala Gln 
            740                 745                 750         

Tyr Gly Asp Phe Ala Asn Val Gly Gln Pro Leu Phe Asp Asn Phe Ile 
        755                 760                 765             

Val Ala Ala Arg Ser Lys Trp Gly Glu Thr Ser Gly Leu Val Leu Leu 
    770                 775                 780                 

Leu Pro His Gly Phe Glu Gly Gln Ala His Glu His Ser Ser Gly Arg 
785                 790                 795                 800 

Val Glu Arg Phe Leu Gln Leu Ala Ala Arg Asn Asn Ile Val Val Ala 
                805                 810                 815     

Asn Val Thr Thr Ser Ala Gln Tyr Phe His Leu Leu Arg Arg Gln Ala 
            820                 825                 830         

Ala Arg Leu Lys Asn Pro Arg Pro Leu Val Ile Met Thr Pro Lys Ser 
        835                 840                 845             

Leu Leu Arg Asn Pro Leu Ala Ala Ser Lys Pro Glu Asp Leu Thr Asn 
    850                 855                 860                 

Gly Arg Phe Gln Pro Val Leu His Phe Ala Lys Thr Gly Glu Gly Ala 
865                 870                 875                 880 

Gln Ala Val Arg Arg Leu Ile Leu Ser Ser Gly Lys Val Gly Val Asp 
                885                 890                 895     

Leu Ala Ala Glu Met Ser Lys Arg Gly Glu Glu Ala Cys Ala His Val 
            900                 905                 910         

Ala Thr Ala Arg Val Glu Gln Leu Tyr Pro Phe Pro Ala Asp Arg Val 
        915                 920                 925             

Lys Asp Val Ile Ala Ser Tyr Pro Asn Leu Gln Glu Val Val Trp Leu 
    930                 935                 940                 

Gln Glu Glu Pro Glu Asn Gln Gly Pro Trp Asn Phe Met Arg Pro Arg 
945                 950                 955                 960 

Leu Gln Glu Leu Leu Pro Ala Ser Val Lys Leu Arg Tyr Ile Gly Arg 
                965                 970                 975     

Pro Glu Gln Gly Phe Val Ala Glu Gly Ser Pro Asp Val His Asn Arg 
            980                 985                 990         

Val Gln Ala Glu Ile Leu Ala Gln Ala Leu Ala Asn Asp Asn His 
        995                 1000                1005        

<210>   298
<211>   1007
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   298
Met Cys Phe Ala Arg Glu Val Leu Arg Gly Asn Ser Asp Cys Gly Ile 
                5                   10                  15      

His Arg Asn Arg Lys Arg Ile Gly Phe Val Leu Pro Val Tyr Ser Phe 
            20                  25                  30          

Ser Asp Thr Arg Pro Glu Phe Leu Leu Gly Ile Pro Gly Cys Pro Lys 
        35                  40                  45              

Ala Pro Gln Ala Gly Ala Pro Ser Cys Pro Val Arg Val Glu Glu Gly 
    50                  55                  60                  

Phe Thr Met Ala Asn Glu Gln Pro Gly Ser Val Gln Thr Phe Trp His 
65                  70                  75                  80  

Gln Phe Ser Gly Pro Asn Leu Ala Tyr Leu Leu Glu Gln Tyr Glu Gln 
                85                  90                  95      

Tyr Leu Ala Asp Pro Asn Ala Val Pro Glu Asp Val Arg Ser Leu Phe 
            100                 105                 110         

Ala Gln Tyr Gly Asp Pro Ala Gln Ala Val Ser Ala Ser Pro Ile Glu 
        115                 120                 125             

Thr Gln Pro Val Phe Gly Pro Gln Val Ser Ala Leu Ser Pro Arg Thr 
    130                 135                 140                 

Leu Glu Ala Ala Ala Lys Ala His Gln Leu Ala Gln Ala Ile Arg Ala 
145                 150                 155                 160 

Asn Gly His Leu Ala Ala Asp Thr Asp Pro Leu Phe Ala Pro Glu Gly 
                165                 170                 175     

Ser Pro Glu Leu Glu Ala Ser Thr Tyr Gly Leu Val Glu Ala Asp Leu 
            180                 185                 190         

Ala Ser Leu Pro Ala Ser Val Val Gly Gly Pro Ile Ala Gln Thr Ala 
        195                 200                 205             

Pro Thr Ala Leu Ala Ala Ile Glu Ala Leu Arg Lys Ala Tyr Cys Ser 
    210                 215                 220                 

Asp Leu Gly Tyr Glu Phe Ala His Leu Ser Ser Arg Glu Glu Arg Ala 
225                 230                 235                 240 

Trp Phe Glu Asp Gln Ile Glu Asn Arg Arg Phe His Gln Pro Leu Thr 
                245                 250                 255     

Leu Asp Glu Ala Lys Ala Leu Tyr Glu Leu Leu Ala Arg Ala Gln Leu 
            260                 265                 270         

Phe Glu Arg Phe Met His Lys Arg Phe Val Gly Gln Lys Arg Phe Ser 
        275                 280                 285             

Val Glu Gly Val Asp Ala Leu Val Pro Met Val Asp Ala Leu Ala Lys 
    290                 295                 300                 

Met Ala Val Asp Ala Gly Phe Asp His Val Phe Ile Gly Met Ala His 
305                 310                 315                 320 

Arg Gly Arg Leu Asn Ile Leu Ala His Val Leu Lys Lys Pro Tyr Glu 
                325                 330                 335     

Arg Ile Phe Ser Glu Phe His Ala Gly Asn Gly Met Ala Ser Asp Glu 
            340                 345                 350         

Glu Leu Ala Glu Tyr Met Leu Gly Trp Gly Gly Asp Val Lys Tyr His 
        355                 360                 365             

Met Gly Trp Thr Arg Thr Phe Glu Thr Pro Asn Gly His Lys Ala Arg 
    370                 375                 380                 

Tyr Val Leu Ser Asn Asn Pro Ser His Leu Glu Phe Val Asp Pro Val 
385                 390                 395                 400 

Val Glu Gly Met Thr Arg Ala Ala Gln Asp Asp Arg Thr Arg Pro Gly 
                405                 410                 415     

Gln Pro Ile Gln Asp Val His Lys Ala Phe Pro Ile Leu Val His Gly 
            420                 425                 430         

Asp Ala Ala Phe Thr Gly Glu Gly Val Val Ala Glu Thr Leu Asn Phe 
        435                 440                 445             

Ser Lys Ile Pro Gly Tyr Tyr Thr Gly Gly Thr Val His Ile Ile Ala 
    450                 455                 460                 

Asn Asn His Leu Gly Phe Thr Ala Asp Pro Glu Gln Gly Arg Ser Thr 
465                 470                 475                 480 

Arg Tyr Ala Ser Asp Ile Ala Lys Gly Tyr Asp Leu Pro Val Val His 
                485                 490                 495     

Val Ser Ala Asp Asn Pro Glu Ala Cys Leu Arg Ala Val Arg Leu Ala 
            500                 505                 510         

Phe Leu Tyr Arg Glu Thr Phe Gln Lys Asp Ile Val Ile Asp Leu Val 
        515                 520                 525             

Gly Tyr Arg Arg Trp Gly His Asn Glu Ser Asp Asp Pro Ala Met Thr 
    530                 535                 540                 

Gln Pro Val Met Tyr Ala Lys Ile Ala Ser His Pro Thr Val Met Glu 
545                 550                 555                 560 

Ile Tyr Ala Asn Glu Leu Val Ala Arg Gly Ala Phe Thr Ala Ala Asp 
                565                 570                 575     

Leu Gln Lys Ile Asp Gln Ala Ile Asp Glu Glu Leu Leu Gln Ala Tyr 
            580                 585                 590         

Lys Lys Tyr Pro Glu Ile His Thr Pro Ala Ala Ile Thr Asp Phe Ser 
        595                 600                 605             

Glu Pro Thr Glu Asp Ala Lys Pro Val Pro Leu Glu Glu Leu Lys Glu 
    610                 615                 620                 

Ile Asn Arg Ala Leu Leu Glu Thr Pro Pro Asp Phe Thr Val Tyr Pro 
625                 630                 635                 640 

Lys Leu Lys Arg Ile Leu Glu Arg Arg Arg Asp Ala Leu Asp Gly Gly 
                645                 650                 655     

Asp Ile Asp Trp Ala His Ala Glu Ala Leu Ala Phe Gly Thr Ile Leu 
            660                 665                 670         

Arg Ser Gly Thr Pro Ile Arg Met Ser Gly Gln Asp Ser Glu Arg Gly 
        675                 680                 685             

Thr Phe Gly Gln Arg His Leu Val Leu His Asp Ala Asn Thr Asn Ala 
    690                 695                 700                 

Arg Tyr Ala Pro Leu Gln His Leu Pro Gly Ala Lys Ala Ser Phe Val 
705                 710                 715                 720 

Val Tyr Asn Ser Pro Leu Ser Glu Thr Ala Val Ile Gly Phe Glu Tyr 
                725                 730                 735     

Gly Tyr Ser Val Glu Ala Lys Asp Ala Leu Val Leu Trp Glu Ala Gln 
            740                 745                 750         

Tyr Gly Asp Phe Ala Asn Val Gly Gln Pro Leu Phe Asp Asn Phe Ile 
        755                 760                 765             

Val Ala Ala Arg Ser Lys Trp Gly Glu Thr Ser Gly Leu Val Leu Leu 
    770                 775                 780                 

Leu Pro His Gly Phe Glu Gly Gln Ala His Glu His Ser Ser Gly Arg 
785                 790                 795                 800 

Val Glu Arg Phe Leu Gln Leu Ala Ala Arg Asn Asn Ile Val Val Ala 
                805                 810                 815     

Asn Val Thr Thr Ser Ala Gln Tyr Phe His Leu Leu Arg Arg Gln Ala 
            820                 825                 830         

Ala Arg Leu Lys Asn Pro Arg Pro Leu Val Ile Met Thr Pro Lys Ser 
        835                 840                 845             

Leu Leu Arg Asn Pro Leu Ala Ala Ser Lys Pro Glu Asp Leu Thr Asn 
    850                 855                 860                 

Gly Arg Phe Gln Pro Val Leu His Phe Ala Arg Thr Gly Glu Gly Ala 
865                 870                 875                 880 

Gln Ala Val Arg Arg Leu Ile Leu Ser Ser Gly Lys Val Gly Val Asp 
                885                 890                 895     

Leu Ala Ala Glu Met Ser Lys Arg Gly Glu Glu Ala Cys Ala His Val 
            900                 905                 910         

Ala Thr Ala Arg Val Glu Gln Leu Tyr Pro Phe Pro Ala Asp Arg Val 
        915                 920                 925             

Lys Asp Val Ile Ala Ser Tyr Pro Asn Leu Gln Glu Val Val Trp Leu 
    930                 935                 940                 

Gln Glu Glu Pro Glu Asn Gln Gly Pro Trp Asn Phe Met Arg Pro Arg 
945                 950                 955                 960 

Leu Gln Glu Leu Leu Pro Ala Ser Val Lys Leu Arg Tyr Ile Gly Arg 
                965                 970                 975     

Pro Glu Gln Gly Phe Val Ala Glu Gly Ser Pro Asp Val His Asn Arg 
            980                 985                 990         

Val Gln Ala Glu Ile Leu Ala Gln Ala Leu Ala Asn Asp Asn His 
        995                 1000                1005        

<210>   299
<211>   1007
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   299
Met Cys Phe Ala Arg Glu Val Leu Arg Gly Asn Ser Asp Cys Gly Ile 
                5                   10                  15      

His Arg Asn Arg Lys Arg Ile Gly Phe Val Leu Pro Val Tyr Ser Phe 
            20                  25                  30          

Ser Asp Thr Arg Pro Glu Phe Leu Leu Gly Ile Pro Gly Cys Pro Lys 
        35                  40                  45              

Ala Pro Gln Ala Gly Ala Pro Ser Cys Pro Val Arg Val Glu Glu Gly 
    50                  55                  60                  

Phe Thr Met Ala Asn Glu Gln Pro Gly Ser Val Gln Thr Phe Trp His 
65                  70                  75                  80  

Gln Phe Ser Gly Pro Asn Leu Ala Tyr Leu Leu Glu Gln Tyr Glu Gln 
                85                  90                  95      

Tyr Leu Ala Asp Pro Asn Ala Val Pro Glu Asp Val Arg Ser Leu Phe 
            100                 105                 110         

Ala Gln Tyr Gly Glu Pro Ala Gln Ala Val Ser Ala Ser Pro Ile Glu 
        115                 120                 125             

Thr Gln Pro Val Phe Gly Pro Gln Val Ser Ala Leu Ser Pro Arg Thr 
    130                 135                 140                 

Leu Glu Ala Ala Ala Lys Ala His Gln Leu Ala Gln Ala Ile Arg Ala 
145                 150                 155                 160 

Asn Gly His Leu Ala Ala Asp Thr Asp Pro Leu Phe Ala Pro Glu Gly 
                165                 170                 175     

Ser Pro Glu Leu Glu Ala Ser Thr Tyr Gly Leu Val Glu Ala Asp Leu 
            180                 185                 190         

Ala Ser Leu Pro Ala Ser Val Val Gly Gly Pro Ile Ala Gln Thr Ala 
        195                 200                 205             

Pro Thr Ala Leu Ala Ala Ile Glu Ala Leu Arg Lys Ala Tyr Cys Ser 
    210                 215                 220                 

Asp Leu Gly Tyr Glu Phe Ala His Leu Ser Ser Arg Glu Glu Arg Ala 
225                 230                 235                 240 

Trp Phe Glu Asp Gln Ile Glu Asn Arg Arg Phe His Gln Pro Leu Thr 
                245                 250                 255     

Leu Asp Glu Ala Lys Ala Leu Tyr Glu Leu Leu Ala Arg Ala Gln Leu 
            260                 265                 270         

Phe Glu Arg Phe Met His Lys Arg Phe Val Gly Gln Lys Arg Phe Ser 
        275                 280                 285             

Val Glu Gly Val Asp Ala Leu Val Pro Met Val Asp Ala Leu Ala Lys 
    290                 295                 300                 

Met Ala Val Asp Ala Gly Phe Asp His Val Phe Ile Gly Met Ala His 
305                 310                 315                 320 

Arg Gly Arg Leu Asn Ile Leu Ala His Val Leu Lys Lys Pro Tyr Glu 
                325                 330                 335     

Arg Ile Phe Ser Glu Phe His Ala Gly Asn Gly Met Ala Ser Asp Glu 
            340                 345                 350         

Glu Leu Ala Glu Tyr Met Leu Gly Trp Gly Gly Asp Val Lys Tyr His 
        355                 360                 365             

Met Gly Trp Thr Arg Thr Phe Glu Thr Pro Asn Gly His Lys Ala Arg 
    370                 375                 380                 

Tyr Val Leu Ser Asn Asn Pro Ser His Leu Glu Phe Val Asp Pro Val 
385                 390                 395                 400 

Val Glu Gly Met Thr Arg Ala Ala Gln Asp Asp Arg Thr Arg Pro Gly 
                405                 410                 415     

Gln Pro Ile Gln Asp Val His Lys Ala Phe Pro Ile Leu Val His Gly 
            420                 425                 430         

Asp Ala Ala Phe Thr Gly Glu Gly Val Val Ala Glu Thr Leu Asn Phe 
        435                 440                 445             

Ser Lys Ile Pro Gly Tyr Tyr Thr Gly Gly Thr Val His Ile Ile Ala 
    450                 455                 460                 

Asn Asn His Leu Gly Phe Thr Ala Asp Pro Glu Gln Gly Arg Ser Thr 
465                 470                 475                 480 

Arg Tyr Ala Ser Asp Ile Ala Lys Gly Tyr Asp Leu Pro Val Val His 
                485                 490                 495     

Val Ser Ala Asp Asn Pro Glu Ala Cys Leu Arg Ala Val Arg Leu Ala 
            500                 505                 510         

Phe Leu Tyr Arg Glu Thr Phe Gln Lys Asp Ile Val Ile Asp Leu Val 
        515                 520                 525             

Gly Tyr Arg Arg Trp Gly His Asn Glu Ser Asp Asp Pro Ala Met Thr 
    530                 535                 540                 

Gln Pro Val Met Tyr Ala Lys Ile Ala Ser His Pro Thr Val Met Glu 
545                 550                 555                 560 

Ile Tyr Ala Asn Glu Leu Val Ala Arg Gly Ala Phe Thr Ala Ala Asp 
                565                 570                 575     

Leu Gln Lys Ile Asp Gln Ala Ile Asp Glu Glu Leu Leu Gln Ala Tyr 
            580                 585                 590         

Lys Lys Tyr Pro Glu Ile His Thr Pro Ala Ala Ile Thr Asp Phe Ser 
        595                 600                 605             

Glu Pro Thr Glu Asp Ala Lys Pro Val Pro Leu Glu Glu Leu Lys Glu 
    610                 615                 620                 

Ile Asn Arg Ala Leu Leu Glu Thr Pro Pro Asp Phe Thr Val Tyr Pro 
625                 630                 635                 640 

Lys Leu Lys Arg Ile Leu Glu Arg Arg Arg Asp Ala Leu Asp Gly Gly 
                645                 650                 655     

Asp Ile Asp Trp Ala His Ala Glu Ala Leu Ala Phe Gly Thr Ile Leu 
            660                 665                 670         

Arg Ser Gly Thr Pro Ile Arg Met Ser Gly Gln Asp Ser Glu Arg Gly 
        675                 680                 685             

Thr Phe Gly Gln Arg His Leu Val Leu His Asp Ala Asn Thr Asn Ala 
    690                 695                 700                 

Arg Tyr Ala Pro Leu Gln His Leu Pro Gly Ala Lys Ala Ser Phe Val 
705                 710                 715                 720 

Val Tyr Asn Ser Pro Leu Ser Glu Thr Ala Val Ile Gly Phe Glu Tyr 
                725                 730                 735     

Gly Tyr Ser Val Glu Ala Lys Asp Ala Leu Val Leu Trp Glu Ala Gln 
            740                 745                 750         

Tyr Gly Asp Phe Ala Asn Val Gly Gln Pro Leu Phe Asp Asn Phe Ile 
        755                 760                 765             

Val Ala Ala Arg Ser Lys Trp Gly Glu Thr Ser Gly Leu Val Leu Leu 
    770                 775                 780                 

Leu Pro His Gly Phe Glu Gly Gln Ala His Glu His Ser Ser Gly Arg 
785                 790                 795                 800 

Val Glu Arg Phe Leu Gln Leu Ala Ala Arg Asn Asn Ile Val Val Ala 
                805                 810                 815     

Asn Val Thr Thr Ser Ala Gln Tyr Phe His Leu Leu Arg Arg Gln Ala 
            820                 825                 830         

Ala Arg Leu Lys Asn Pro Arg Pro Leu Val Ile Met Thr Pro Lys Ser 
        835                 840                 845             

Leu Leu Arg Asn Pro Leu Ala Ala Ser Lys Pro Glu Asp Leu Thr Asn 
    850                 855                 860                 

Gly Arg Phe Gln Pro Val Leu His Phe Ala Lys Thr Gly Glu Gly Ala 
865                 870                 875                 880 

Gln Ala Val Arg Arg Leu Ile Leu Ser Ser Gly Lys Val Gly Val Asp 
                885                 890                 895     

Leu Ala Ala Glu Met Ser Lys Arg Gly Glu Glu Ala Cys Ala His Val 
            900                 905                 910         

Ala Thr Ala Arg Val Glu Gln Leu Tyr Pro Phe Pro Ala Asp Arg Val 
        915                 920                 925             

Lys Asp Val Ile Ala Ser Tyr Pro Asn Leu Gln Glu Val Val Trp Leu 
    930                 935                 940                 

Gln Glu Glu Pro Glu Asn Gln Gly Pro Trp Asn Phe Met Arg Pro Arg 
945                 950                 955                 960 

Leu Gln Glu Leu Leu Pro Ala Ser Val Lys Leu Arg Tyr Ile Gly Arg 
                965                 970                 975     

Pro Glu Gln Gly Phe Val Ala Glu Gly Ser Pro Asp Val His Asn Arg 
            980                 985                 990         

Val Gln Ala Glu Ile Leu Ala Gln Ala Leu Ala Asn Asp Asn His 
        995                 1000                1005        

<210>   300
<211>   1007
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   300
Met Cys Phe Ala Arg Glu Val Leu Arg Gly Asn Ser Asp Cys Gly Ile 
                5                   10                  15      

His Arg Asn Arg Lys Arg Ile Gly Phe Val Leu Pro Val Tyr Ser Phe 
            20                  25                  30          

Ser Asp Thr Arg Pro Glu Phe Leu Leu Gly Ile Pro Gly Cys Pro Lys 
        35                  40                  45              

Ala Pro Gln Ala Gly Ala Pro Ser Cys Pro Val Arg Val Glu Glu Gly 
    50                  55                  60                  

Phe Thr Met Ala Asn Glu Gln Pro Gly Ser Val Gln Thr Phe Trp His 
65                  70                  75                  80  

Gln Phe Ser Gly Pro Asn Leu Ala Tyr Leu Leu Glu Gln Tyr Glu Gln 
                85                  90                  95      

Tyr Leu Ala Asp Pro Asn Ala Val Pro Glu Asp Val Arg Ser Leu Phe 
            100                 105                 110         

Ala Gln Tyr Gly Asp Pro Ala Gln Ala Val Ser Ala Ser Pro Ile Glu 
        115                 120                 125             

Thr Gln Pro Val Phe Gly Pro Gln Val Ser Ala Leu Ser Pro Arg Thr 
    130                 135                 140                 

Leu Glu Ala Ala Ala Lys Ala His Gln Leu Ala Gln Ala Ile Arg Ala 
145                 150                 155                 160 

Asn Gly His Leu Ala Ala Asp Thr Asp Pro Leu Phe Ala Pro Glu Gly 
                165                 170                 175     

Ser Pro Glu Leu Glu Ala Ser Thr Tyr Gly Leu Val Glu Ala Asp Leu 
            180                 185                 190         

Ala Ser Leu Pro Ala Ser Val Val Gly Gly Pro Ile Ala Gln Thr Ala 
        195                 200                 205             

Pro Thr Ala Leu Ala Ala Ile Glu Ala Leu Arg Lys Ala Tyr Cys Ser 
    210                 215                 220                 

Glu Leu Gly Tyr Glu Phe Ala His Leu Ser Ser Arg Glu Glu Arg Ala 
225                 230                 235                 240 

Trp Phe Glu Asp Gln Ile Glu Asn Arg Arg Phe His Gln Pro Leu Thr 
                245                 250                 255     

Leu Asp Glu Ala Lys Ala Leu Tyr Glu Leu Leu Ala Arg Ala Gln Leu 
            260                 265                 270         

Phe Glu Arg Phe Met His Lys Arg Phe Val Gly Gln Lys Arg Phe Ser 
        275                 280                 285             

Val Glu Gly Val Asp Ala Leu Val Pro Met Val Asp Ala Leu Ala Lys 
    290                 295                 300                 

Met Ala Val Asp Ala Gly Phe Asp His Val Phe Ile Gly Met Ala His 
305                 310                 315                 320 

Arg Gly Arg Leu Asn Ile Leu Ala His Val Leu Lys Lys Pro Tyr Glu 
                325                 330                 335     

Arg Ile Phe Ser Glu Phe His Ala Gly Asn Gly Met Ala Ser Asp Glu 
            340                 345                 350         

Glu Leu Ala Glu Tyr Met Leu Gly Trp Gly Gly Asp Val Lys Tyr His 
        355                 360                 365             

Met Gly Trp Thr Arg Thr Phe Glu Thr Pro Asn Gly His Lys Ala Arg 
    370                 375                 380                 

Tyr Val Leu Ser Asn Asn Pro Ser His Leu Glu Phe Val Asp Pro Val 
385                 390                 395                 400 

Val Glu Gly Met Thr Arg Ala Ala Gln Asp Asp Arg Thr Arg Pro Gly 
                405                 410                 415     

Gln Pro Ile Gln Asp Val His Lys Ala Phe Pro Ile Leu Val His Gly 
            420                 425                 430         

Asp Ala Ala Phe Thr Gly Glu Gly Val Val Ala Glu Thr Leu Asn Phe 
        435                 440                 445             

Ser Lys Ile Pro Gly Tyr Tyr Thr Gly Gly Thr Val His Ile Ile Ala 
    450                 455                 460                 

Asn Asn His Leu Gly Phe Thr Ala Asp Pro Glu Gln Gly Arg Ser Thr 
465                 470                 475                 480 

Arg Tyr Ala Ser Asp Ile Ala Lys Gly Tyr Asp Leu Pro Val Val His 
                485                 490                 495     

Val Ser Ala Asp Asn Pro Glu Ala Cys Leu Arg Ala Val Arg Leu Ala 
            500                 505                 510         

Phe Leu Tyr Arg Glu Thr Phe Gln Lys Asp Ile Val Ile Asp Leu Val 
        515                 520                 525             

Gly Tyr Arg Arg Trp Gly His Asn Glu Ser Asp Asp Pro Ala Met Thr 
    530                 535                 540                 

Gln Pro Val Met Tyr Ala Lys Ile Ala Ser His Pro Thr Val Met Glu 
545                 550                 555                 560 

Ile Tyr Ala Asn Glu Leu Val Ala Arg Gly Ala Phe Thr Ala Ala Asp 
                565                 570                 575     

Leu Gln Lys Ile Asp Gln Ala Ile Asp Glu Glu Leu Leu Gln Ala Tyr 
            580                 585                 590         

Lys Lys Tyr Pro Glu Ile His Thr Pro Ala Ala Ile Thr Asp Phe Ser 
        595                 600                 605             

Glu Pro Thr Glu Asp Ala Lys Pro Val Pro Leu Glu Glu Leu Lys Glu 
    610                 615                 620                 

Ile Asn Arg Ala Leu Leu Glu Thr Pro Pro Asp Phe Thr Val Tyr Pro 
625                 630                 635                 640 

Lys Leu Lys Arg Ile Leu Glu Arg Arg Arg Asp Ala Leu Asp Gly Gly 
                645                 650                 655     

Asp Ile Asp Trp Ala His Ala Glu Ala Leu Ala Phe Gly Thr Ile Leu 
            660                 665                 670         

Arg Ser Gly Thr Pro Ile Arg Met Ser Gly Gln Asp Ser Glu Arg Gly 
        675                 680                 685             

Thr Phe Gly Gln Arg His Leu Val Leu His Asp Ala Asn Thr Asn Ala 
    690                 695                 700                 

Arg Tyr Ala Pro Leu Gln His Leu Pro Gly Ala Lys Ala Ser Phe Val 
705                 710                 715                 720 

Val Tyr Asn Ser Pro Leu Ser Glu Thr Ala Val Ile Gly Phe Glu Tyr 
                725                 730                 735     

Gly Tyr Ser Val Glu Ala Lys Asp Ala Leu Val Leu Trp Glu Ala Gln 
            740                 745                 750         

Tyr Gly Asp Phe Ala Asn Val Gly Gln Pro Leu Phe Asp Asn Phe Ile 
        755                 760                 765             

Val Ala Ala Arg Ser Lys Trp Gly Glu Thr Ser Gly Leu Val Leu Leu 
    770                 775                 780                 

Leu Pro His Gly Phe Glu Gly Gln Ala His Glu His Ser Ser Gly Arg 
785                 790                 795                 800 

Val Glu Arg Phe Leu Gln Leu Ala Ala Arg Asn Asn Ile Val Val Ala 
                805                 810                 815     

Asn Val Thr Thr Ser Ala Gln Tyr Phe His Leu Leu Arg Arg Gln Ala 
            820                 825                 830         

Ala Arg Leu Lys Asn Pro Arg Pro Leu Val Ile Met Thr Pro Lys Ser 
        835                 840                 845             

Leu Leu Arg Asn Pro Leu Ala Ala Ser Lys Pro Glu Asp Leu Thr Asn 
    850                 855                 860                 

Gly Arg Phe Gln Pro Val Leu His Phe Ala Lys Thr Gly Glu Gly Ala 
865                 870                 875                 880 

Gln Ala Val Arg Arg Leu Ile Leu Ser Ser Gly Lys Val Gly Val Asp 
                885                 890                 895     

Leu Ala Ala Glu Met Ser Lys Arg Gly Glu Glu Ala Cys Ala His Val 
            900                 905                 910         

Ala Thr Ala Arg Val Glu Gln Leu Tyr Pro Phe Pro Ala Asp Arg Val 
        915                 920                 925             

Lys Asp Val Ile Ala Ser Tyr Pro Asn Leu Gln Glu Val Val Trp Leu 
    930                 935                 940                 

Gln Glu Glu Pro Glu Asn Gln Gly Pro Trp Asn Phe Met Arg Pro Arg 
945                 950                 955                 960 

Leu Gln Glu Leu Leu Pro Ala Ser Val Lys Leu Arg Tyr Ile Gly Arg 
                965                 970                 975     

Pro Glu Gln Gly Phe Val Ala Glu Gly Ser Pro Asp Val His Asn Arg 
            980                 985                 990         

Val Gln Ala Glu Ile Leu Ala Gln Ala Leu Ala Asn Asp Asn His 
        995                 1000                1005        

<210>   301
<211>   1007
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   301
Met Cys Phe Ala Arg Glu Val Leu Arg Gly Asn Ser Asp Cys Gly Ile 
                5                   10                  15      

His Arg Asn Arg Lys Arg Ile Gly Phe Val Leu Pro Val Tyr Ser Phe 
            20                  25                  30          

Ser Asp Thr Arg Pro Glu Phe Leu Leu Gly Ile Pro Gly Cys Pro Lys 
        35                  40                  45              

Ala Pro Gln Ala Gly Ala Pro Ser Cys Pro Val Arg Val Glu Glu Gly 
    50                  55                  60                  

Phe Thr Met Ala Asn Glu Gln Pro Gly Ser Val Gln Thr Phe Trp His 
65                  70                  75                  80  

Gln Phe Ser Gly Pro Asn Leu Ala Tyr Leu Leu Glu Gln Tyr Glu Gln 
                85                  90                  95      

Tyr Leu Ala Asp Pro Asn Ala Val Pro Glu Asp Val Arg Ser Leu Phe 
            100                 105                 110         

Ala Gln Tyr Gly Asp Pro Ala Gln Ala Val Ser Ala Ser Pro Ile Glu 
        115                 120                 125             

Thr Gln Pro Val Phe Gly Pro Gln Val Ser Ala Leu Ser Pro Arg Thr 
    130                 135                 140                 

Leu Glu Ala Ala Ala Lys Ala His Gln Leu Ala Gln Ala Ile Arg Ala 
145                 150                 155                 160 

Asn Gly His Leu Ala Ala Asp Thr Asp Pro Leu Phe Ala Pro Glu Gly 
                165                 170                 175     

Ser Pro Glu Leu Glu Ala Ser Thr Tyr Gly Leu Val Glu Ala Asp Leu 
            180                 185                 190         

Ala Ser Leu Pro Ala Ser Val Val Gly Gly Pro Ile Ala Gln Thr Ala 
        195                 200                 205             

Pro Thr Ala Leu Ala Ala Ile Glu Ala Leu Arg Lys Ala Tyr Cys Ser 
    210                 215                 220                 

Asp Leu Gly Tyr Glu Phe Ala His Leu Ser Ser Arg Glu Glu Arg Ala 
225                 230                 235                 240 

Trp Phe Glu Asp Gln Ile Glu Asn Arg Arg Phe His Gln Pro Leu Thr 
                245                 250                 255     

Leu Asp Asp Ala Lys Ala Leu Tyr Glu Leu Leu Ala Arg Ala Gln Leu 
            260                 265                 270         

Phe Glu Arg Phe Met His Lys Arg Phe Val Gly Gln Lys Arg Phe Ser 
        275                 280                 285             

Val Glu Gly Val Asp Ala Leu Val Pro Met Val Asp Ala Leu Ala Lys 
    290                 295                 300                 

Met Ala Val Asp Ala Gly Phe Asp His Val Phe Ile Gly Met Ala His 
305                 310                 315                 320 

Arg Gly Arg Leu Asn Ile Leu Ala His Val Leu Lys Lys Pro Tyr Glu 
                325                 330                 335     

Arg Ile Phe Ser Glu Phe His Ala Gly Asn Gly Met Ala Ser Asp Glu 
            340                 345                 350         

Glu Leu Ala Glu Tyr Met Leu Gly Trp Gly Gly Asp Val Lys Tyr His 
        355                 360                 365             

Met Gly Trp Thr Arg Thr Phe Glu Thr Pro Asn Gly His Lys Ala Arg 
    370                 375                 380                 

Tyr Val Leu Ser Asn Asn Pro Ser His Leu Glu Phe Val Asp Pro Val 
385                 390                 395                 400 

Val Glu Gly Met Thr Arg Ala Ala Gln Asp Asp Arg Thr Arg Pro Gly 
                405                 410                 415     

Gln Pro Ile Gln Asp Val His Lys Ala Phe Pro Ile Leu Val His Gly 
            420                 425                 430         

Asp Ala Ala Phe Thr Gly Glu Gly Val Val Ala Glu Thr Leu Asn Phe 
        435                 440                 445             

Ser Lys Ile Pro Gly Tyr Tyr Thr Gly Gly Thr Val His Ile Ile Ala 
    450                 455                 460                 

Asn Asn His Leu Gly Phe Thr Ala Asp Pro Glu Gln Gly Arg Ser Thr 
465                 470                 475                 480 

Arg Tyr Ala Ser Asp Ile Ala Lys Gly Tyr Asp Leu Pro Val Val His 
                485                 490                 495     

Val Ser Ala Asp Asn Pro Glu Ala Cys Leu Arg Ala Val Arg Leu Ala 
            500                 505                 510         

Phe Leu Tyr Arg Glu Thr Phe Gln Lys Asp Ile Val Ile Asp Leu Val 
        515                 520                 525             

Gly Tyr Arg Arg Trp Gly His Asn Glu Ser Asp Asp Pro Ala Met Thr 
    530                 535                 540                 

Gln Pro Val Met Tyr Ala Lys Ile Ala Ser His Pro Thr Val Met Glu 
545                 550                 555                 560 

Ile Tyr Ala Asn Glu Leu Val Ala Arg Gly Ala Phe Thr Ala Ala Asp 
                565                 570                 575     

Leu Gln Lys Ile Asp Gln Ala Ile Asp Glu Glu Leu Leu Gln Ala Tyr 
            580                 585                 590         

Lys Lys Tyr Pro Glu Ile His Thr Pro Ala Ala Ile Thr Asp Phe Ser 
        595                 600                 605             

Glu Pro Thr Glu Asp Ala Lys Pro Val Pro Leu Glu Glu Leu Lys Glu 
    610                 615                 620                 

Ile Asn Arg Ala Leu Leu Glu Thr Pro Pro Asp Phe Thr Val Tyr Pro 
625                 630                 635                 640 

Lys Leu Lys Arg Ile Leu Glu Arg Arg Arg Asp Ala Leu Asp Gly Gly 
                645                 650                 655     

Asp Ile Asp Trp Ala His Ala Glu Ala Leu Ala Phe Gly Thr Ile Leu 
            660                 665                 670         

Arg Ser Gly Thr Pro Ile Arg Met Ser Gly Gln Asp Ser Glu Arg Gly 
        675                 680                 685             

Thr Phe Gly Gln Arg His Leu Val Leu His Asp Ala Asn Thr Asn Ala 
    690                 695                 700                 

Arg Tyr Ala Pro Leu Gln His Leu Pro Gly Ala Lys Ala Ser Phe Val 
705                 710                 715                 720 

Val Tyr Asn Ser Pro Leu Ser Glu Thr Ala Val Ile Gly Phe Glu Tyr 
                725                 730                 735     

Gly Tyr Ser Val Glu Ala Lys Asp Ala Leu Val Leu Trp Glu Ala Gln 
            740                 745                 750         

Tyr Gly Asp Phe Ala Asn Val Gly Gln Pro Leu Phe Asp Asn Phe Ile 
        755                 760                 765             

Val Ala Ala Arg Ser Lys Trp Gly Glu Thr Ser Gly Leu Val Leu Leu 
    770                 775                 780                 

Leu Pro His Gly Phe Glu Gly Gln Ala His Glu His Ser Ser Gly Arg 
785                 790                 795                 800 

Val Glu Arg Phe Leu Gln Leu Ala Ala Arg Asn Asn Ile Val Val Ala 
                805                 810                 815     

Asn Val Thr Thr Ser Ala Gln Tyr Phe His Leu Leu Arg Arg Gln Ala 
            820                 825                 830         

Ala Arg Leu Lys Asn Pro Arg Pro Leu Val Ile Met Thr Pro Lys Ser 
        835                 840                 845             

Leu Leu Arg Asn Pro Leu Ala Ala Ser Lys Pro Glu Asp Leu Thr Asn 
    850                 855                 860                 

Gly Arg Phe Gln Pro Val Leu His Phe Ala Lys Thr Gly Glu Gly Ala 
865                 870                 875                 880 

Gln Ala Val Arg Arg Leu Ile Leu Ser Ser Gly Lys Val Gly Val Asp 
                885                 890                 895     

Leu Ala Ala Glu Met Ser Lys Arg Gly Glu Glu Ala Cys Ala His Val 
            900                 905                 910         

Ala Thr Ala Arg Val Glu Gln Leu Tyr Pro Phe Pro Ala Asp Arg Val 
        915                 920                 925             

Lys Asp Val Ile Ala Ser Tyr Pro Asn Leu Gln Glu Val Val Trp Leu 
    930                 935                 940                 

Gln Glu Glu Pro Glu Asn Gln Gly Pro Trp Asn Phe Met Arg Pro Arg 
945                 950                 955                 960 

Leu Gln Glu Leu Leu Pro Ala Ser Val Lys Leu Arg Tyr Ile Gly Arg 
                965                 970                 975     

Pro Glu Gln Gly Phe Val Ala Glu Gly Ser Pro Asp Val His Asn Arg 
            980                 985                 990         

Val Gln Ala Glu Ile Leu Ala Gln Ala Leu Ala Asn Asp Asn His 
        995                 1000                1005        

<210>   302
<211>   3024
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   302
gtgtgctttg cgcgcgaagt tttgcgcggg aattccgact gtggtataca tagaaatcgg       60

aaaaggatag ggtttgtcct acccgtctat tcattctctg acaccaggcc ggaattcctg      120

cttgggatcc ccgggtgtcc caaggcgccc caagcgggtg ctccgtcatg cccagtgcgc      180

gtggaagagg ggttcacaat ggcgaacgaa caacctggat cagtgcagac gttctggcat      240

cagttctcag ggccgaactt ggcctacctg ctcgagcagt atgagcagta tctcgcggat      300

cccaacgccg tgccggagga cgtgcgcagc ttattcgcgc aatacgggga tccggctcag      360

gcggtatctg cttcaccgat agagacacaa ccggtgttcg gacctcaggt ttccgctttg      420

tcgcctcgca cgctggatgc cgcggcgaag gcccaccaat tggctcaagc catccgcgcg      480

aacggccatc tcgcggcgga taccgatccg ctgtttgctc ccgaaggttc tcccgaactg      540

gaagcgtcga cgtacggcct tgtggaagcc gatctcgcct cattgcccgc ctcggtggtg      600

ggaggcccca tcgcgcagac tgcgccgacc gcactcgcgg ccatcgaggc gctgcggaag      660

gcgtactgca gcgacctggg ctacgagttt gcccatcttt cgagccgcga agagcgggcg      720

tggttcgagg atcagatcga aaaccgacgg ttccatcagc cgctcacctt ggacgaggcg      780

aaggcgcttt acgagctgct ggcgcgcgcg cagttgttcg agcggttcat gcacaagcgc      840

ttcgtcggcc agaagcggtt ttccgtcgaa ggtgtcgacg cgctcgttcc catggtggat      900

gcgcttgcga agatggcggt ggacgccggt ttcgatcacg tcttcatcgg catggcgcac      960

cgcggccgcc tgaatatcct cgcgcacgtg ctgaagaagc cctacgagcg catcttctcc     1020

gagttccacg ccggcaacgg catggcctcg gacgaggaac tcgcggaata catgctcggc     1080

tggggcggcg acgtaaagta ccacatgggc tggacgcgca ccttcgagac gccgaacggc     1140

cataaggcgc gctatgtgct gtccaacaac ccgagccatt tggaattcgt ggatcccgtc     1200

gtcgaaggca tgacgcgcgc ggcgcaggac gaccgcacgc ggcccgggca gcccattcag     1260

gacgtgcaca aggcgttccc cattctggtt cacggcgacg ccgcgttcac cggcgagggt     1320

gtggtcgctg agacgctcaa cttctcgaag atccccggct attacaccgg cggaacggtg     1380

cacatcatcg ccaataacca cctcggcttc accgctgacc cggagcaggg ccggtcgacg     1440

cgttacgcga gcgacattgc caagggctac gatctgccgg tcgtccacgt ttccgcggac     1500

aatccggaag cgtgtctgcg cgcggtgcgc ctcgccttcc tgtatcgcga gacgttccag     1560

aaggacatcg tgatcgatct cgtcgggtat cgccgttggg gccacaacga gtcggacgat     1620

cccgccatga cgcagccggt gatgtacgcg aagatcgcct cccatccgac cgtgatggag     1680

atctacgcaa acgagctcgt cgcgcggggc gcgttcacgg cggcggacct gcagaagatc     1740

gatcaggcca tcgacgagga actgctgcag gcgtacaaga agtacccgga gattcacacg     1800

cctgcggcca tcacggactt ctcggagccc acggaggacg caaagcccgt acccctggag     1860

gaactgaaag agatcaaccg ggcgctcttg gagacgccgc ccgacttcac ggtgtacccg     1920

aagctgaagc gcatcctgga gcggcgccgg gacgcgctcg acggaggcga catcgactgg     1980

gcgcatgccg aggccctggc gtttggaacc atcctgcgat ccggcacgcc catccgcatg     2040

tccggccagg actcggagcg cgggacgttc ggccagcgcc acctcgtgct ccacgacgcg     2100

aacaccaacg cgcgctacgc tccgctccag cacctgccgg gagccaaggc gagctttgtg     2160

gtgtacaata gcccgctttc ggagacggcc gtgatcgggt tcgaatacgg ctattcggtc     2220

gaagcgaagg acgcgctcgt tctgtgggaa gcgcagtacg gcgacttcgc caacgtcggt     2280

cagcccctgt ttgacaactt catcgtggcc gcgcgatcga agtgggggga gacctccggg     2340

ctggtgttgc ttttgccgca cgggttcgag gggcaggcgc acgagcactc gagtggccgc     2400

gtggagcgat tcctgcagct cgccgctcgc aacaacatcg tggtggcgaa cgtgacgacc     2460

tccgcgcagt acttccatct gctgcggcgc caggcggcac ggctcaaaaa cccgcgtccg     2520

ctcgtcatca tgacgccgaa gagcttgctc aggaacccgc ttgcggcctc gaagccggaa     2580

gatctgacca acggccgatt tcagccggtt ctgcacttcg ccaagacggg ggagggcgcg     2640

caggcggttc gccgcctgat tctctcgagt ggcaaggtgg gcgtcgatct cgccgcggag     2700

atgtcgaagc ggggcgagga ggcgtgcgcg cacgtcgcca ccgcgcgcgt cgagcagctg     2760

tacccgttcc cggcggatcg cgtgaaggac gtcatcgcgt cgtatcccaa cctgcaagag     2820

gtggtgtggc tccaggagga gcccgagaac caggggccgt ggaacttcat gcggccgagg     2880

ttgcaggaac ttcttccggc gtcggtgaaa ctccgttata tcggccgtcc cgagcagggc     2940

tttgtcgcgg aaggatcgcc ggacgtgcac aaccgcgtgc aggctgaaat tttggcgcag     3000

gcgttggcca acgataacca ttaa                                            3024


<210>   303
<211>   3024
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   303
gtgtgctttg cgcgcgaagt tttgcgcggg aattccgact gtggtataca tagaaatcgg       60

aaaaggatag ggtttgtcct acccgtctat tcattctctg acaccaggcc ggaattcctg      120

cttgggatcc ccgggtgtcc caaggcgccc caagcgggtg ctccgtcatg cccagtgcgc      180

gtggaagagg ggttcacaat ggcgaacgaa caacctggat cagtgcagac gttctggcat      240

cagttctcag ggccgaactt ggcctacctg ctcgagcagt atgagcagta tctcgcggat      300

cccaacgccg tgccggagga cgtgcgcagc ttattcgcgc aatacgggga tccggctcag      360

gcggtatctg cttcaccgat agagacacaa ccggtgttcg gacctcaggt ttccgctttg      420

tcgcctcgca cgctggaggc cgcggcgaag gcccaccaat tggctcaagc catccgcgcg      480

aacggccatc tcgcggcgga taccgatccg ctgtttgctc ccgaaggttc tcccgaactg      540

gaagcgtcga cgtacggcct tgtggaagcc gatctcgcct cattgcccgc ctcggtggtg      600

ggaggcccca tcgcgcagac tgcgccgacc gcactcgcgg ccatcgaggc gctgcggaag      660

gcgtactgca gcgacctggg ctacgagttt gcccatcttt cgagccgcga agagcgggcg      720

tggttcgagg atcagatcga aaaccgacgg ttccatcagc cgctcacctt ggacgaggcg      780

aaggcgcttt acgagctgct ggcgcgcgcg cagttgttcg agcggttcat gcacaagcgc      840

ttcgtcggcc agaagcggtt ttccgtcgaa ggtgtcgacg cgctcgttcc catggtggat      900

gcgcttgcga agatggcggt ggacgccggt ttcgatcacg tcttcatcgg catggcgcac      960

cgcggccgcc tgaatatcct cgcgcacgtg ctgaagaagc cctacgagcg catcttctcc     1020

gagttccacg ccggcaacgg catggcctcg gacgaggaac tcgcggaata catgctcggc     1080

tggggcggcg acgtaaagta ccacatgggc tggacgcgca ccttcgagac gccgaacggc     1140

cataaggcgc gctatgtgct gtccaacaac ccgagccatt tggaattcgt ggatcccgtc     1200

gtcgaaggca tgacgcgcgc ggcgcaggac gaccgcacgc ggcccgggca gcccattcag     1260

gacgtgcaca aggcgttccc cattctggtt cacggcgacg ccgcgttcac cggcgagggt     1320

gtggtcgctg agacgctcaa cttctcgaag atccccggct attacaccgg cggaacggtg     1380

cacatcatcg ccaataacca cctcggcttc accgctgacc cggagcaggg ccggtcgacg     1440

cgttacgcga gcgacattgc caagggctac gatctgccgg tcgtccacgt ttccgcggac     1500

aatccggaag cgtgtctgcg cgcggtgcgc ctcgccttcc tgtatcgcga gacgttccag     1560

aaggacatcg tgatcgatct cgtcgggtat cgccgttggg gccacaacga gtcggacgat     1620

cccgccatga cgcagccggt gatgtacgcg aagatcgcct cccatccgac cgtgatggag     1680

atctacgcaa acgagctcgt cgcgcggggc gcgttcacgg cggcggacct gcagaagatc     1740

gatcaggcca tcgacgagga actgctgcag gcgtacaaga agtacccgga gattcacacg     1800

cctgcggcca tcacggactt ctcggagccc acggaggacg caaagcccgt acccctggag     1860

gaactgaaag agatcaaccg ggcgctcttg gagacgccgc ccgacttcac ggtgtacccg     1920

aagctgaagc gcatcctgga gcggcgccgg gacgcgctcg acggaggcga catcgactgg     1980

gcgcatgccg aggccctggc gtttggaacc atcctgcgat ccggcacgcc catccgcatg     2040

tccggccagg actcggagcg cgggacgttc ggccagcgcc acctcgtgct ccacgacgcg     2100

aacaccaacg cgcgctacgc tccgctccag cacctgccgg gagccaaggc gagctttgtg     2160

gtgtacaata gcccgctttc ggagacggcc gtgatcgggt tcgaatacgg ctattcggtc     2220

gaagcgaagg acgcgctcgt tctgtgggaa gcgcagtacg gcgacttcgc caacgtcggt     2280

cagcccctgt ttgacaactt catcgtggcc gcgcgatcga agtgggggga gacctccggg     2340

ctggtgttgc ttttgccgca cgggttcgag gggcaggcgc acgagcactc gagtggccgc     2400

gtggagcgat tcctgcagct cgccgctcgc aacaacatcg tggtggcgaa cgtgacgacc     2460

tccgcgcagt acttccatct gctgcggcgc caggcggcac ggctcaaaaa cccgcgtccg     2520

ctcgtcatca tgacgccgaa gagcttgctc aggaacccgc ttgcggcctc gaagccggaa     2580

gatctgacca acggccgatt tcagccggtt ctgcacttcg cccgtacggg ggagggcgcg     2640

caggcggttc gccgcctgat tctctcgagt ggcaaggtgg gcgtcgatct cgccgcggag     2700

atgtcgaagc ggggcgagga ggcgtgcgcg cacgtcgcca ccgcgcgcgt cgagcagctg     2760

tacccgttcc cggcggatcg cgtgaaggac gtcatcgcgt cgtatcccaa cctgcaagag     2820

gtggtgtggc tccaggagga gcccgagaac caggggccgt ggaacttcat gcggccgagg     2880

ttgcaggaac ttcttccggc gtcggtgaaa ctccgttata tcggccgtcc cgagcagggc     2940

tttgtcgcgg aaggatcgcc ggacgtgcac aaccgcgtgc aggctgaaat tttggcgcag     3000

gcgttggcca acgataacca ttaa                                            3024


<210>   304
<211>   3024
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   304
gtgtgctttg cgcgcgaagt tttgcgcggg aattccgact gtggtataca tagaaatcgg       60

aaaaggatag ggtttgtcct acccgtctat tcattctctg acaccaggcc ggaattcctg      120

cttgggatcc ccgggtgtcc caaggcgccc caagcgggtg ctccgtcatg cccagtgcgc      180

gtggaagagg ggttcacaat ggcgaacgaa caacctggat cagtgcagac gttctggcat      240

cagttctcag ggccgaactt ggcctacctg ctcgagcagt atgagcagta tctcgcggat      300

cccaacgccg tgccggagga cgtgcgcagc ttattcgcgc aatacgggga accggctcag      360

gcggtatctg cttcaccgat agagacacaa ccggtgttcg gacctcaggt ttccgctttg      420

tcgcctcgca cgctggaggc cgcggcgaag gcccaccaat tggctcaagc catccgcgcg      480

aacggccatc tcgcggcgga taccgatccg ctgtttgctc ccgaaggttc tcccgaactg      540

gaagcgtcga cgtacggcct tgtggaagcc gatctcgcct cattgcccgc ctcggtggtg      600

ggaggcccca tcgcgcagac tgcgccgacc gcactcgcgg ccatcgaggc gctgcggaag      660

gcgtactgca gcgacctggg ctacgagttt gcccatcttt cgagccgcga agagcgggcg      720

tggttcgagg atcagatcga aaaccgacgg ttccatcagc cgctcacctt ggacgaggcg      780

aaggcgcttt acgagctgct ggcgcgcgcg cagttgttcg agcggttcat gcacaagcgc      840

ttcgtcggcc agaagcggtt ttccgtcgaa ggtgtcgacg cgctcgttcc catggtggat      900

gcgcttgcga agatggcggt ggacgccggt ttcgatcacg tcttcatcgg catggcgcac      960

cgcggccgcc tgaatatcct cgcgcacgtg ctgaagaagc cctacgagcg catcttctcc     1020

gagttccacg ccggcaacgg catggcctcg gacgaggaac tcgcggaata catgctcggc     1080

tggggcggcg acgtaaagta ccacatgggc tggacgcgca ccttcgagac gccgaacggc     1140

cataaggcgc gctatgtgct gtccaacaac ccgagccatt tggaattcgt ggatcccgtc     1200

gtcgaaggca tgacgcgcgc ggcgcaggac gaccgcacgc ggcccgggca gcccattcag     1260

gacgtgcaca aggcgttccc cattctggtt cacggcgacg ccgcgttcac cggcgagggt     1320

gtggtcgctg agacgctcaa cttctcgaag atccccggct attacaccgg cggaacggtg     1380

cacatcatcg ccaataacca cctcggcttc accgctgacc cggagcaggg ccggtcgacg     1440

cgttacgcga gcgacattgc caagggctac gatctgccgg tcgtccacgt ttccgcggac     1500

aatccggaag cgtgtctgcg cgcggtgcgc ctcgccttcc tgtatcgcga gacgttccag     1560

aaggacatcg tgatcgatct cgtcgggtat cgccgttggg gccacaacga gtcggacgat     1620

cccgccatga cgcagccggt gatgtacgcg aagatcgcct cccatccgac cgtgatggag     1680

atctacgcaa acgagctcgt cgcgcggggc gcgttcacgg cggcggacct gcagaagatc     1740

gatcaggcca tcgacgagga actgctgcag gcgtacaaga agtacccgga gattcacacg     1800

cctgcggcca tcacggactt ctcggagccc acggaggacg caaagcccgt acccctggag     1860

gaactgaaag agatcaaccg ggcgctcttg gagacgccgc ccgacttcac ggtgtacccg     1920

aagctgaagc gcatcctgga gcggcgccgg gacgcgctcg acggaggcga catcgactgg     1980

gcgcatgccg aggccctggc gtttggaacc atcctgcgat ccggcacgcc catccgcatg     2040

tccggccagg actcggagcg cgggacgttc ggccagcgcc acctcgtgct ccacgacgcg     2100

aacaccaacg cgcgctacgc tccgctccag cacctgccgg gagccaaggc gagctttgtg     2160

gtgtacaata gcccgctttc ggagacggcc gtgatcgggt tcgaatacgg ctattcggtc     2220

gaagcgaagg acgcgctcgt tctgtgggaa gcgcagtacg gcgacttcgc caacgtcggt     2280

cagcccctgt ttgacaactt catcgtggcc gcgcgatcga agtgggggga gacctccggg     2340

ctggtgttgc ttttgccgca cgggttcgag gggcaggcgc acgagcactc gagtggccgc     2400

gtggagcgat tcctgcagct cgccgctcgc aacaacatcg tggtggcgaa cgtgacgacc     2460

tccgcgcagt acttccatct gctgcggcgc caggcggcac ggctcaaaaa cccgcgtccg     2520

ctcgtcatca tgacgccgaa gagcttgctc aggaacccgc ttgcggcctc gaagccggaa     2580

gatctgacca acggccgatt tcagccggtt ctgcacttcg ccaagacggg ggagggcgcg     2640

caggcggttc gccgcctgat tctctcgagt ggcaaggtgg gcgtcgatct cgccgcggag     2700

atgtcgaagc ggggcgagga ggcgtgcgcg cacgtcgcca ccgcgcgcgt cgagcagctg     2760

tacccgttcc cggcggatcg cgtgaaggac gtcatcgcgt cgtatcccaa cctgcaagag     2820

gtggtgtggc tccaggagga gcccgagaac caggggccgt ggaacttcat gcggccgagg     2880

ttgcaggaac ttcttccggc gtcggtgaaa ctccgttata tcggccgtcc cgagcagggc     2940

tttgtcgcgg aaggatcgcc ggacgtgcac aaccgcgtgc aggctgaaat tttggcgcag     3000

gcgttggcca acgataacca ttaa                                            3024


<210>   305
<211>   3024
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   305
gtgtgctttg cgcgcgaagt tttgcgcggg aattccgact gtggtataca tagaaatcgg       60

aaaaggatag ggtttgtcct acccgtctat tcattctctg acaccaggcc ggaattcctg      120

cttgggatcc ccgggtgtcc caaggcgccc caagcgggtg ctccgtcatg cccagtgcgc      180

gtggaagagg ggttcacaat ggcgaacgaa caacctggat cagtgcagac gttctggcat      240

cagttctcag ggccgaactt ggcctacctg ctcgagcagt atgagcagta tctcgcggat      300

cccaacgccg tgccggagga cgtgcgcagc ttattcgcgc aatacgggga tccggctcag      360

gcggtatctg cttcaccgat agagacacaa ccggtgttcg gacctcaggt ttccgctttg      420

tcgcctcgca cgctggaggc cgcggcgaag gcccaccaat tggctcaagc catccgcgcg      480

aacggccatc tcgcggcgga taccgatccg ctgtttgctc ccgaaggttc tcccgaactg      540

gaagcgtcga cgtacggcct tgtggaagcc gatctcgcct cattgcccgc ctcggtggtg      600

ggaggcccca tcgcgcagac tgcgccgacc gcactcgcgg ccatcgaggc gctgcggaag      660

gcgtactgca gcgaactggg ctacgagttt gcccatcttt cgagccgcga agagcgggcg      720

tggttcgagg atcagatcga aaaccgacgg ttccatcagc cgctcacctt ggacgaggcg      780

aaggcgcttt acgagctgct ggcgcgcgcg cagttgttcg agcggttcat gcacaagcgc      840

ttcgtcggcc agaagcggtt ttccgtcgaa ggtgtcgacg cgctcgttcc catggtggat      900

gcgcttgcga agatggcggt ggacgccggt ttcgatcacg tcttcatcgg catggcgcac      960

cgcggccgcc tgaatatcct cgcgcacgtg ctgaagaagc cctacgagcg catcttctcc     1020

gagttccacg ccggcaacgg catggcctcg gacgaggaac tcgcggaata catgctcggc     1080

tggggcggcg acgtaaagta ccacatgggc tggacgcgca ccttcgagac gccgaacggc     1140

cataaggcgc gctatgtgct gtccaacaac ccgagccatt tggaattcgt ggatcccgtc     1200

gtcgaaggca tgacgcgcgc ggcgcaggac gaccgcacgc ggcccgggca gcccattcag     1260

gacgtgcaca aggcgttccc cattctggtt cacggcgacg ccgcgttcac cggcgagggt     1320

gtggtcgctg agacgctcaa cttctcgaag atccccggct attacaccgg cggaacggtg     1380

cacatcatcg ccaataacca cctcggcttc accgctgacc cggagcaggg ccggtcgacg     1440

cgttacgcga gcgacattgc caagggctac gatctgccgg tcgtccacgt ttccgcggac     1500

aatccggaag cgtgtctgcg cgcggtgcgc ctcgccttcc tgtatcgcga gacgttccag     1560

aaggacatcg tgatcgatct cgtcgggtat cgccgttggg gccacaacga gtcggacgat     1620

cccgccatga cgcagccggt gatgtacgcg aagatcgcct cccatccgac cgtgatggag     1680

atctacgcaa acgagctcgt cgcgcggggc gcgttcacgg cggcggacct gcagaagatc     1740

gatcaggcca tcgacgagga actgctgcag gcgtacaaga agtacccgga gattcacacg     1800

cctgcggcca tcacggactt ctcggagccc acggaggacg caaagcccgt acccctggag     1860

gaactgaaag agatcaaccg ggcgctcttg gagacgccgc ccgacttcac ggtgtacccg     1920

aagctgaagc gcatcctgga gcggcgccgg gacgcgctcg acggaggcga catcgactgg     1980

gcgcatgccg aggccctggc gtttggaacc atcctgcgat ccggcacgcc catccgcatg     2040

tccggccagg actcggagcg cgggacgttc ggccagcgcc acctcgtgct ccacgacgcg     2100

aacaccaacg cgcgctacgc tccgctccag cacctgccgg gagccaaggc gagctttgtg     2160

gtgtacaata gcccgctttc ggagacggcc gtgatcgggt tcgaatacgg ctattcggtc     2220

gaagcgaagg acgcgctcgt tctgtgggaa gcgcagtacg gcgacttcgc caacgtcggt     2280

cagcccctgt ttgacaactt catcgtggcc gcgcgatcga agtgggggga gacctccggg     2340

ctggtgttgc ttttgccgca cgggttcgag gggcaggcgc acgagcactc gagtggccgc     2400

gtggagcgat tcctgcagct cgccgctcgc aacaacatcg tggtggcgaa cgtgacgacc     2460

tccgcgcagt acttccatct gctgcggcgc caggcggcac ggctcaaaaa cccgcgtccg     2520

ctcgtcatca tgacgccgaa gagcttgctc aggaacccgc ttgcggcctc gaagccggaa     2580

gatctgacca acggccgatt tcagccggtt ctgcacttcg ccaagacggg ggagggcgcg     2640

caggcggttc gccgcctgat tctctcgagt ggcaaggtgg gcgtcgatct cgccgcggag     2700

atgtcgaagc ggggcgagga ggcgtgcgcg cacgtcgcca ccgcgcgcgt cgagcagctg     2760

tacccgttcc cggcggatcg cgtgaaggac gtcatcgcgt cgtatcccaa cctgcaagag     2820

gtggtgtggc tccaggagga gcccgagaac caggggccgt ggaacttcat gcggccgagg     2880

ttgcaggaac ttcttccggc gtcggtgaaa ctccgttata tcggccgtcc cgagcagggc     2940

tttgtcgcgg aaggatcgcc ggacgtgcac aaccgcgtgc aggctgaaat tttggcgcag     3000

gcgttggcca acgataacca ttaa                                            3024


<210>   306
<211>   3024
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   306
gtgtgctttg cgcgcgaagt tttgcgcggg aattccgact gtggtataca tagaaatcgg       60

aaaaggatag ggtttgtcct acccgtctat tcattctctg acaccaggcc ggaattcctg      120

cttgggatcc ccgggtgtcc caaggcgccc caagcgggtg ctccgtcatg cccagtgcgc      180

gtggaagagg ggttcacaat ggcgaacgaa caacctggat cagtgcagac gttctggcat      240

cagttctcag ggccgaactt ggcctacctg ctcgagcagt atgagcagta tctcgcggat      300

cccaacgccg tgccggagga cgtgcgcagc ttattcgcgc aatacgggga tccggctcag      360

gcggtatctg cttcaccgat agagacacaa ccggtgttcg gacctcaggt ttccgctttg      420

tcgcctcgca cgctggaggc cgcggcgaag gcccaccaat tggctcaagc catccgcgcg      480

aacggccatc tcgcggcgga taccgatccg ctgtttgctc ccgaaggttc tcccgaactg      540

gaagcgtcga cgtacggcct tgtggaagcc gatctcgcct cattgcccgc ctcggtggtg      600

ggaggcccca tcgcgcagac tgcgccgacc gcactcgcgg ccatcgaggc gctgcggaag      660

gcgtactgca gcgacctggg ctacgagttt gcccatcttt cgagccgcga agagcgggcg      720

tggttcgagg atcagatcga aaaccgacgg ttccatcagc cgctcacctt ggacgatgcg      780

aaggcgcttt acgagctgct ggcgcgcgcg cagttgttcg agcggttcat gcacaagcgc      840

ttcgtcggcc agaagcggtt ttccgtcgaa ggtgtcgacg cgctcgttcc catggtggat      900

gcgcttgcga agatggcggt ggacgccggt ttcgatcacg tcttcatcgg catggcgcac      960

cgcggccgcc tgaatatcct cgcgcacgtg ctgaagaagc cctacgagcg catcttctcc     1020

gagttccacg ccggcaacgg catggcctcg gacgaggaac tcgcggaata catgctcggc     1080

tggggcggcg acgtaaagta ccacatgggc tggacgcgca ccttcgagac gccgaacggc     1140

cataaggcgc gctatgtgct gtccaacaac ccgagccatt tggaattcgt ggatcccgtc     1200

gtcgaaggca tgacgcgcgc ggcgcaggac gaccgcacgc ggcccgggca gcccattcag     1260

gacgtgcaca aggcgttccc cattctggtt cacggcgacg ccgcgttcac cggcgagggt     1320

gtggtcgctg agacgctcaa cttctcgaag atccccggct attacaccgg cggaacggtg     1380

cacatcatcg ccaataacca cctcggcttc accgctgacc cggagcaggg ccggtcgacg     1440

cgttacgcga gcgacattgc caagggctac gatctgccgg tcgtccacgt ttccgcggac     1500

aatccggaag cgtgtctgcg cgcggtgcgc ctcgccttcc tgtatcgcga gacgttccag     1560

aaggacatcg tgatcgatct cgtcgggtat cgccgttggg gccacaacga gtcggacgat     1620

cccgccatga cgcagccggt gatgtacgcg aagatcgcct cccatccgac cgtgatggag     1680

atctacgcaa acgagctcgt cgcgcggggc gcgttcacgg cggcggacct gcagaagatc     1740

gatcaggcca tcgacgagga actgctgcag gcgtacaaga agtacccgga gattcacacg     1800

cctgcggcca tcacggactt ctcggagccc acggaggacg caaagcccgt acccctggag     1860

gaactgaaag agatcaaccg ggcgctcttg gagacgccgc ccgacttcac ggtgtacccg     1920

aagctgaagc gcatcctgga gcggcgccgg gacgcgctcg acggaggcga catcgactgg     1980

gcgcatgccg aggccctggc gtttggaacc atcctgcgat ccggcacgcc catccgcatg     2040

tccggccagg actcggagcg cgggacgttc ggccagcgcc acctcgtgct ccacgacgcg     2100

aacaccaacg cgcgctacgc tccgctccag cacctgccgg gagccaaggc gagctttgtg     2160

gtgtacaata gcccgctttc ggagacggcc gtgatcgggt tcgaatacgg ctattcggtc     2220

gaagcgaagg acgcgctcgt tctgtgggaa gcgcagtacg gcgacttcgc caacgtcggt     2280

cagcccctgt ttgacaactt catcgtggcc gcgcgatcga agtgggggga gacctccggg     2340

ctggtgttgc ttttgccgca cgggttcgag gggcaggcgc acgagcactc gagtggccgc     2400

gtggagcgat tcctgcagct cgccgctcgc aacaacatcg tggtggcgaa cgtgacgacc     2460

tccgcgcagt acttccatct gctgcggcgc caggcggcac ggctcaaaaa cccgcgtccg     2520

ctcgtcatca tgacgccgaa gagcttgctc aggaacccgc ttgcggcctc gaagccggaa     2580

gatctgacca acggccgatt tcagccggtt ctgcacttcg ccaagacggg ggagggcgcg     2640

caggcggttc gccgcctgat tctctcgagt ggcaaggtgg gcgtcgatct cgccgcggag     2700

atgtcgaagc ggggcgagga ggcgtgcgcg cacgtcgcca ccgcgcgcgt cgagcagctg     2760

tacccgttcc cggcggatcg cgtgaaggac gtcatcgcgt cgtatcccaa cctgcaagag     2820

gtggtgtggc tccaggagga gcccgagaac caggggccgt ggaacttcat gcggccgagg     2880

ttgcaggaac ttcttccggc gtcggtgaaa ctccgttata tcggccgtcc cgagcagggc     2940

tttgtcgcgg aaggatcgcc ggacgtgcac aaccgcgtgc aggctgaaat tttggcgcag     3000

gcgttggcca acgataacca ttaa                                            3024


<210>   307
<211>   549
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   307
Met Ile Tyr Thr Leu Tyr Gly Leu Ser Lys Ser Val Glu Arg Cys Gly 
                5                   10                  15      

Asn Arg Leu Ile Ser Ala Arg Gly Arg Ser Ala Arg Arg Arg Met Ser 
            20                  25                  30          

Thr Val Trp Phe Ala Gly Arg Ile Lys Val Arg Pro His Leu His Lys 
        35                  40                  45              

Asp Gly Ile Asp Met Asp Gly Lys Thr Arg Ser Asp Val Ala Leu Ile 
    50                  55                  60                  

Gly Gly Gly Ile Met Ser Ala Thr Leu Gly Thr Leu Phe Arg Gln Leu 
65                  70                  75                  80  

Ala Pro Asp Trp Thr Ile Thr Val Phe Glu Arg Leu Asp Glu Val Ala 
                85                  90                  95      

Val Glu Ser Ser Asn Glu Trp Asn Asn Ala Gly Thr Gly His Ser Ala 
            100                 105                 110         

Leu Cys Glu Leu Asn Tyr Thr Val Glu Gln Pro Asp Gly Ser Ile Asp 
        115                 120                 125             

Ile Ser Lys Ala Ile Gln Val Asn Glu Gln Phe Leu Val Ser Arg Gln 
    130                 135                 140                 

Phe Trp Ser Phe Leu Val Arg Gln Gly Ile Ile Glu His Pro Arg Asp 
145                 150                 155                 160 

Phe Ile Val Pro Val Pro His Met Ser Phe Val Gln Gly Glu Thr Asn 
                165                 170                 175     

Val Ala Phe Leu Lys Lys Arg His Gln Leu Leu Ser Gln His Pro Leu 
            180                 185                 190         

Phe Gln Gly Met Glu Tyr Ser Glu Asp Pro Glu Arg Leu Arg Glu Trp 
        195                 200                 205             

Ile Pro Leu Met Met Lys Asp Arg Lys Leu Asp Arg Pro Ile Ala Ala 
    210                 215                 220                 

Thr Trp Ile Ala Ser Gly Thr Asp Val Asn Phe Gly Ala Leu Thr Arg 
225                 230                 235                 240 

Met Leu Phe Gln Tyr Leu Glu Arg Glu Gly Val Asp Val Gln Cys Gly 
                245                 250                 255     

Lys Glu Val Gln Asp Leu Lys Arg Thr Arg Asp Gly Met Trp Gln Leu 
            260                 265                 270         

Arg Val Arg Asp Val Lys Thr Gly Ala Thr Tyr Glu His Val Ser Lys 
        275                 280                 285             

Phe Val Phe Val Gly Ala Gly Gly Trp Ser Leu Leu Leu Leu Gln Lys 
    290                 295                 300                 

Ser Gly Ile Asp Glu Gly Lys Gly Ile Gly Gly Phe Pro Val Ser Gly 
305                 310                 315                 320 

Leu Phe Met Val Cys Glu Asn Pro Glu Ile Val Arg Gln His Arg Ala 
                325                 330                 335     

Lys Val Tyr Gly Lys Ala Pro Val Gly Ala Pro Pro Met Ser Val Pro 
            340                 345                 350         

His Leu Asp Ser Arg Val Ile Gly Gly Arg Glu Tyr Val Leu Phe Gly 
        355                 360                 365             

Pro Phe Ala Gly Phe Ser Pro Arg Phe Leu Lys Thr Gly Ser Met Leu 
    370                 375                 380                 

Asp Leu Leu Lys Ser Val Lys Leu His Asn Leu Ser Thr Leu Leu Ala 
385                 390                 395                 400 

Ala Gly Ala Lys Asn Ala Ser Leu Thr Leu Tyr Leu Ile Arg Gln Leu 
                405                 410                 415     

Met Leu Thr Lys Lys Gln Arg Met Asp Glu Leu Arg Glu Phe Val Pro 
            420                 425                 430         

Thr Ala Arg Asp Glu Asp Trp Arg Leu Val Val Ala Gly Gln Arg Val 
        435                 440                 445             

Gln Val Ile Lys Arg Arg Pro Arg Gly Glu Leu Gln Phe Gly Thr Glu 
    450                 455                 460                 

Val Val Ser Ala Arg Asp Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser 
465                 470                 475                 480 

Pro Gly Ala Ser Val Val Val Ser Ile Met Leu Glu Val Ile Arg Lys 
                485                 490                 495     

Cys Phe Pro Asp Arg Leu Pro Glu Trp Glu Asn Lys Ile Arg Glu Met 
            500                 505                 510         

Ile Pro Ser Tyr Gly Val Thr Leu Arg His Arg Pro Asp Leu Met Arg 
        515                 520                 525             

Ser Ile Gln Ala Glu Thr Ala Glu Val Leu Gly Leu His Arg Met Glu 
    530                 535                 540                 

Ala Arg Thr Asp Ala 
545                 

<210>   308
<211>   1650
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   308
atgatttata ctctatacgg gttgtcgaaa tccgttgaac ggtgcggaaa ccgcttgatt       60

tcggcgcgcg gacgttcagc gcggcgccga atgtcgacag tttggtttgc ggggcgcatc      120

aaggtgcgcc cgcatctgca taaggatggg atcgacatgg acggaaagac gagatcggat      180

gtcgccctga ttggcggcgg catcatgagt gccacgctgg ggaccttgtt tcggcagctt      240

gcgcccgatt ggaccatcac cgtgttcgaa cgcctcgacg aggtcgcggt ggagagttcg      300

aacgagtgga acaacgcggg cacggggcac tctgcgctct gcgagctgaa ctacacggtc      360

gaacagccag acggaagcat cgacatctcc aaggccattc aggtgaacga gcagttcctg      420

gtctctcgcc aattttggtc gttcctcgtg cgacagggca tcatcgaaca tccgagagat      480

tttatcgtgc ctgtgccgca catgagcttc gtgcagggcg agacgaacgt ggcgtttttg      540

aagaaacggc accagttgtt gtcccagcac ccgcttttcc aagggatgga atactccgag      600

gatcccgagc ggctccggga atggattccg ctgatgatga aggatcgcaa gctggatcgc      660

ccgattgccg ctacgtggat cgcgtccggc acggacgtga acttcggcgc gctcacccgg      720

atgctgttcc aatacctgga gcgcgaaggc gtggacgttc agtgcggcaa agaggtccag      780

gacttgaagc gtacgcgcga cggcatgtgg cagctccgcg tgcgcgatgt gaagacgggc      840

gccacctatg agcatgtgtc gaagttcgtc ttcgtcgggg ccgggggatg gagtctactg      900

cttctgcaga aatccggcat tgacgagggg aagggcatcg gtggcttccc ggtgagcggt      960

cttttcatgg tctgcgagaa tcccgagatt gtccgccagc accgcgccaa ggtgtatggc     1020

aaggcccccg tgggtgcgcc tcccatgtcc gtgccgcacc tggattctcg cgtcatcggc     1080

ggccgagagt atgtcctgtt cgggccgttc gccgggtttt caccgcgctt tttgaagacg     1140

ggctccatgc tcgacctact gaagtcggtc aagcttcaca acctgtcgac cctgctcgcc     1200

gcgggcgcca agaacgcctc gctgacgctg tatctcatcc gacagctcat gctgacgaaa     1260

aagcagcgca tggacgagct gcgcgagttc gtgcccacgg cacgtgatga ggattggcgc     1320

ctcgttgtcg cgggccaacg cgtccaggtc atcaagcggc gcccgcgagg cgagctgcag     1380

ttcggcaccg aggtggtgag cgccagggac ggatccatcg ctgcgctgct cggcgcatcg     1440

ccgggcgcgt cggtcgtggt gtccatcatg ctcgaggtca tccgcaaatg tttcccggac     1500

cggctgcccg agtgggagaa caagatccgc gagatgatcc cgtcgtacgg cgtcacgctg     1560

cgccacagac ccgatctgat gcgttccatc caggccgaga cggccgaggt gctggggctg     1620

catcggatgg aggcccgaac ggacgcgtga                                      1650


<210>   309
<211>   488
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   309
Gln Thr Lys Thr Asp Val Ile Leu Ile Gly Ala Gly Ile Met Ser Ala 
                5                   10                  15      

Thr Leu Gly Thr Leu Leu Lys Glu Leu Ala Pro Glu Trp Asp Ile Thr 
            20                  25                  30          

Val Phe Glu Arg Leu Glu Glu Ala Gly Val Glu Ser Ser Asn Glu Trp 
        35                  40                  45              

Asn Asn Ala Gly Thr Gly His Ala Ala Leu Cys Glu Leu Asn Tyr Thr 
    50                  55                  60                  

Val Glu Lys Pro Asp Gly Ser Ile Asp Ile Ser Lys Ala Ile Lys Ile 
65                  70                  75                  80  

Asn Glu Gln Phe Tyr Val Ser Leu Gln Phe Trp Ala Tyr Leu Val Asn 
                85                  90                  95      

Ser Gly Val Leu Arg Asp Pro Lys Glu Phe Ile Arg Pro Leu Pro His 
            100                 105                 110         

Met Ser Phe Val Gln Gly Glu Asp Asn Val Ala Phe Leu Lys Lys Arg 
        115                 120                 125             

Tyr Glu Thr Met Val Asn Asn Pro Leu Phe Lys Gly Met Glu Phe Ser 
    130                 135                 140                 

Asp Asp Pro Lys Lys Leu Ala Glu Trp Ile Pro Leu Met Met Glu Asn 
145                 150                 155                 160 

Arg Val Val Asn Glu Pro Ile Ala Ala Thr Arg Ile Glu Ser Gly Thr 
                165                 170                 175     

Asp Val Asn Phe Gly Ala Leu Thr Arg Lys Leu Phe Glu His Leu Lys 
            180                 185                 190         

Arg Lys Asn Val Glu Ile His Tyr Arg His His Val Asp Asp Ile Lys 
        195                 200                 205             

Arg Thr Ser Asp Gly Leu Trp Glu Leu Lys Val Arg Asp Leu Asp Ser 
    210                 215                 220                 

Gly Ala Val Glu Arg His Val Ala Lys Phe Val Phe Ile Gly Ala Gly 
225                 230                 235                 240 

Gly Gly Ser Leu His Leu Leu Gln Lys Ser Gly Ile Pro Glu Gly Arg 
                245                 250                 255     

Gly Ile Gly Gly Phe Pro Val Ser Gly Leu Phe Met Val Cys Asn Asn 
            260                 265                 270         

Pro Asp Val Val Glu Gln His His Ala Lys Val Tyr Gly Lys Ala Lys 
        275                 280                 285             

Val Gly Ala Pro Pro Met Ser Val Pro His Leu Asp Thr Arg Phe Ile 
    290                 295                 300                 

Asn Asn Gln Lys Met Leu Leu Phe Gly Pro Phe Ala Gly Phe Ser Pro 
305                 310                 315                 320 

Lys Phe Leu Lys Asn Gly Ser Met Leu Asp Leu Phe Thr Ser Val Lys 
                325                 330                 335     

Pro His Asn Leu Leu Thr Met Leu Ala Ala Gly Val Lys Asn Met Ala 
            340                 345                 350         

Leu Thr Asn Tyr Leu Ile Gln Gln Val Met Leu Ser Lys Glu Gln Arg 
        355                 360                 365             

Met Glu Glu Leu Arg Glu Phe Val Pro Thr Ala Lys Ser Glu Glu Trp 
    370                 375                 380                 

Asp Val Ile Val Ala Gly Gln Arg Val Gln Val Ile Lys Asp Thr Glu 
385                 390                 395                 400 

Ala Gly Gly Lys Gly Thr Leu Gln Phe Gly Thr Glu Val Val His Ala 
                405                 410                 415     

Ala Asp Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser Pro Gly Ala Ser 
            420                 425                 430         

Thr Ala Val His Val Met Leu Glu Val Ile Thr Lys Cys Phe Pro Glu 
        435                 440                 445             

Arg Met Lys Glu Trp Glu Pro Lys Val Arg Glu Met Ile Pro Ser Tyr 
    450                 455                 460                 

Gly Val Ser Leu Met Lys Asn Glu Arg Leu Leu His Asp Val Gln Ala 
465                 470                 475                 480 

Ala Thr Ala Glu Met Leu Gly Leu 
                485             

<210>   310
<211>   487
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   310
Lys Met Asp Val Ile Leu Ile Gly Ala Gly Ile Met Ser Ala Thr Leu 
                5                   10                  15      

Gly Thr Leu Leu Lys Glu Leu Ala Pro Glu Trp Asp Ile Val Val Phe 
            20                  25                  30          

Glu Arg Leu Glu Glu Ala Gly Ala Glu Ser Ser Asn Glu Trp Asn Asn 
        35                  40                  45              

Ala Gly Thr Gly His Ala Ala Leu Cys Glu Leu Asn Tyr Thr Val Glu 
    50                  55                  60                  

Lys Ala Asp Gly Ser Ile Asp Ile Gly Lys Ala Ile Lys Ile Asn Glu 
65                  70                  75                  80  

Gln Phe Tyr Val Ser Leu Gln Phe Trp Ala Tyr Leu Val Asn Ser Gly 
                85                  90                  95      

Ile Leu Arg Asp Pro Lys Asp Phe Val Arg Pro Leu Pro His Met Ser 
            100                 105                 110         

Phe Val Gln Gly Glu Asp Asn Val Ala Phe Leu Lys Lys Arg His Glu 
        115                 120                 125             

Thr Met Ala Ala Asn Pro Leu Phe Lys Gly Met Glu Phe Thr Asp Asp 
    130                 135                 140                 

Pro Lys Lys Leu Ala Glu Trp Val Pro Leu Met Met Glu Gly Arg Val 
145                 150                 155                 160 

Val Asp Glu Pro Ile Ala Ala Thr Arg Ile Glu Ser Gly Thr Asp Val 
                165                 170                 175     

Asn Phe Gly Ala Leu Thr Arg Gln Leu Phe Glu His Leu Lys Arg Lys 
            180                 185                 190         

Asn Val Glu Ile Arg Tyr Arg His His Val Glu Asp Ile Lys Arg Thr 
        195                 200                 205             

Ser Asp Gly Leu Trp Glu Leu Lys Val Arg Asn Leu Asp Thr Gly Thr 
    210                 215                 220                 

Val Glu Leu His Ala Ala Lys Phe Val Phe Ile Gly Ala Gly Gly Gly 
225                 230                 235                 240 

Ser Leu His Leu Leu Gln Lys Ser Gly Ile Pro Glu Gly Lys Gly Ile 
                245                 250                 255     

Gly Gly Phe Pro Val Ser Gly Leu Phe Met Val Cys Asn Asn Pro Glu 
            260                 265                 270         

Val Val Glu Gln His His Ala Lys Val Tyr Gly Lys Ala Lys Val Gly 
        275                 280                 285             

Ala Pro Pro Met Ser Val Pro His Leu Asp Thr Arg Phe Ile Asp Asn 
    290                 295                 300                 

Gln Lys Met Leu Leu Phe Gly Pro Phe Ala Gly Phe Ser Pro Lys Phe 
305                 310                 315                 320 

Leu Lys Asn Gly Ser Met Leu Asp Leu Phe Thr Ser Ile Lys Pro His 
                325                 330                 335     

Asn Val Leu Thr Ile Leu Ala Ala Gly Val Lys Asn Met Ser Leu Thr 
            340                 345                 350         

Asn Tyr Leu Ile Gln Gln Val Leu Leu Ser Lys Glu Gln Arg Met Gln 
        355                 360                 365             

Glu Leu Arg Glu Phe Val Pro Thr Ala Lys Ser Asp Glu Trp Asp Ile 
    370                 375                 380                 

Val Val Ala Gly Gln Arg Val Gln Val Ile Lys Asp Thr Glu Ser Gly 
385                 390                 395                 400 

Gly Lys Gly Thr Leu Gln Phe Gly Thr Glu Val Val His Ala Ala Asp 
                405                 410                 415     

Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser Pro Gly Ala Ser Thr Ala 
            420                 425                 430         

Val His Val Met Leu Glu Val Met Glu Lys Cys Phe Pro Glu Arg Met 
        435                 440                 445             

Asn Glu Trp Arg Ala Lys Val Lys Glu Met Ile Pro Ser Tyr Gly Glu 
    450                 455                 460                 

Ser Leu Met Lys Asn Glu Ala Leu Leu Arg Gln Val Gln Ala Ser Thr 
465                 470                 475                 480 

Ala Glu Ala Leu Gly Leu Asn 
                485         

<210>   311
<211>   490
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   311
Lys Thr Asp Val Ile Leu Ile Gly Ala Gly Ile Met Ser Ala Thr Leu 
                5                   10                  15      

Gly Thr Leu Leu Lys Glu Leu Thr Pro Asp Trp Glu Ile Thr Val Tyr 
            20                  25                  30          

Glu Lys Leu Ala Lys Pro Ala Glu Glu Ser Ser Asn Glu Trp Asn Asn 
        35                  40                  45              

Ala Gly Thr Gly His Ser Ala Leu Cys Glu Leu Asn Tyr Thr Pro Glu 
    50                  55                  60                  

Lys Pro Asp Gly Ser Ile Asp Ile Thr Lys Ala Val Asn Val Asn Glu 
65                  70                  75                  80  

Gln Phe Gln Leu Ser Arg Gln Phe Trp Ser Tyr Leu Val Ser Lys Gly 
                85                  90                  95      

Leu Ile His Asn Pro Gln Asp Phe Ile Arg Pro Ile Pro His Met Ser 
            100                 105                 110         

Leu Val Glu Gly Glu Ala Asn Val Ala Phe Leu Lys Lys Arg Phe Lys 
        115                 120                 125             

Ala Leu Ser Ala His Pro Leu Phe Glu Gly Met Thr Phe Ser Asp Asp 
    130                 135                 140                 

Pro Glu Gln Leu Lys Glu Trp Ile Pro Leu Val Met Glu Gly Arg Thr 
145                 150                 155                 160 

Ser Asn Glu Pro Ile Ala Ala Thr Lys Ser Asp Ala Gly Thr Asp Val 
                165                 170                 175     

Asn Phe Gly Ala Leu Thr Arg Ile Leu Phe Asp His Leu Glu Arg Gln 
            180                 185                 190         

Asp Val Glu Ile Asn Tyr Lys His Ala Val Gln Asp Ile Gln Arg Thr 
        195                 200                 205             

Pro Glu Gly Asn Trp Glu Val Lys Val His Asp Ile Glu His Asn Arg 
    210                 215                 220                 

Ile Glu Tyr His Thr Ala Lys Phe Ile Phe Ile Gly Ala Gly Gly Gly 
225                 230                 235                 240 

Ser Leu Pro Leu Leu Gln Lys Thr Gly Ile Pro Glu Ser Lys His Ile 
                245                 250                 255     

Gly Gly Phe Pro Val Ser Gly Leu Phe Met Val Cys Asn Asn Pro Glu 
            260                 265                 270         

Val Ile Asn Arg His His Ala Lys Val Tyr Gly Lys Ala Lys Val Gly 
        275                 280                 285             

Ala Pro Pro Met Ser Val Pro His Leu Asp Thr Arg Tyr Ile Asp His 
    290                 295                 300                 

Lys Lys Cys Leu Leu Phe Gly Pro Phe Ala Gly Phe Ser Pro Lys Phe 
305                 310                 315                 320 

Leu Lys Thr Gly Ser Asn Leu Asp Leu Ile Gly Ser Val Lys Pro Asn 
                325                 330                 335     

Asn Val Val Thr Met Leu Ala Ser Gly Ala Lys Asn Val Pro Leu Val 
            340                 345                 350         

Lys Tyr Leu Ile Gly Gln Leu Leu Leu Ser Asp Glu Lys Arg Leu Glu 
        355                 360                 365             

Thr Leu Gln Glu Phe Ile Pro Asp Ala Arg Leu Glu Asp Trp Asp Val 
    370                 375                 380                 

Val Val Ala Gly Gln Arg Val Gln Val Ile Lys Asp Thr Glu Ala Gly 
385                 390                 395                 400 

Gly Lys Gly Thr Leu Gln Phe Gly Thr Glu Val Val Thr Ala Ala Asp 
                405                 410                 415     

Gly Ser Val Ala Ala Leu Leu Gly Ala Ser Pro Gly Ala Ser Thr Ala 
            420                 425                 430         

Val His Val Met Leu Glu Val Ile Glu Lys Cys Phe Pro Asp Arg Lys 
        435                 440                 445             

Asn Ala Trp Ala Pro Lys Ile Lys Glu Met Ile Pro Ser Tyr Gly Val 
    450                 455                 460                 

Arg Leu Ala Glu Asn Pro Glu Leu Leu His Gln Ile His Ala Glu Thr 
465                 470                 475                 480 

Ala Glu Thr Leu Gly Leu Thr Glu Lys Glu 
                485                 490 

<210>   312
<211>   492
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   312
Gln Asn Lys Thr Asp Val Ile Leu Ile Gly Ala Gly Ile Met Ser Ala 
                5                   10                  15      

Thr Leu Gly Ser Leu Leu Lys Glu Leu Lys Pro Glu Trp Glu Ile Lys 
            20                  25                  30          

Val Phe Glu Lys Leu Ala Asn Ala Gly Glu Glu Ser Ser Asn Glu Trp 
        35                  40                  45              

Asn Asn Ala Gly Thr Gly His Ala Ala Leu Cys Glu Leu Asn Tyr Thr 
    50                  55                  60                  

Ala Glu Lys Ser Asp Gly Thr Ile Asp Ile Ser Lys Ala Val Lys Ile 
65                  70                  75                  80  

Asn Glu Gln Phe Gln Ile Ser Arg Gln Phe Trp Ala Tyr Leu Val Ser 
                85                  90                  95      

Gln Asn Leu Ile Ser Asn Pro Gln Asp Phe Ile Met Pro Ile Pro His 
            100                 105                 110         

Met Ser Leu Val Gln Gly Glu Asp Asn Val Ala Tyr Leu Lys Lys Arg 
        115                 120                 125             

Phe Lys Ala Leu Ser Asn Ile Pro Leu Phe Glu Gly Met Glu Phe Ser 
    130                 135                 140                 

Asn Asp Pro Glu Lys Leu Lys Glu Trp Ile Pro Leu Val Met Glu Gly 
145                 150                 155                 160 

Arg Thr Ser Asn Glu Pro Ile Ala Ala Thr Lys Ile Asp Ser Gly Thr 
                165                 170                 175     

Asp Val Asn Phe Gly Ala Leu Thr Arg Met Leu Phe Glu His Leu Lys 
            180                 185                 190         

Glu Gln Asn Val Glu Val His Tyr Lys His Ser Val Lys Asp Ile Lys 
        195                 200                 205             

Arg Thr Ser Asp Gly Ser Trp Ser Val Lys Val Gln Glu Ile Glu Ser 
    210                 215                 220                 

Gly Thr Ile Glu Tyr His Thr Ala Asn Phe Val Phe Ile Gly Gly Gly 
225                 230                 235                 240 

Gly Gly Ser Leu Pro Leu Leu Gln Lys Thr Gly Ile Pro Glu Ser Lys 
                245                 250                 255     

Asn Ile Gly Gly Phe Pro Val Ser Gly Leu Phe Met Val Cys Asn Asn 
            260                 265                 270         

Pro Glu Val Val Glu Gln His His Ala Lys Val Tyr Gly Lys Ala Lys 
        275                 280                 285             

Val Gly Ala Pro Pro Met Ser Val Pro His Leu Asp Thr Arg Tyr Ile 
    290                 295                 300                 

Asp Asn Lys Lys Ser Leu Leu Phe Gly Pro Phe Ala Gly Phe Ser Pro 
305                 310                 315                 320 

Lys Phe Leu Lys Thr Gly Ser Asn Phe Asp Leu Ile Gly Ser Val Lys 
                325                 330                 335     

Pro Tyr Asn Val Phe Thr Met Leu Ala Ala Gly Ala Lys Glu Met Ser 
            340                 345                 350         

Leu Thr Lys Tyr Leu Ile Gln Gln Val Met Leu Ser Lys Glu Lys Arg 
        355                 360                 365             

Met Ala Glu Leu Arg Glu Phe Met Pro Asn Ala Lys Ser Glu Asp Trp 
    370                 375                 380                 

Asp Ile Val Val Ala Gly Gln Arg Val Gln Val Ile Lys Asp Thr Glu 
385                 390                 395                 400 

Ala Gly Gly Lys Gly Thr Leu Gln Phe Gly Thr Glu Val Val Ser Ser 
                405                 410                 415     

Ala Asp Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser Pro Gly Ala Ser 
            420                 425                 430         

Thr Ala Val His Val Met Leu Glu Val Leu Glu Lys Cys Phe Pro His 
        435                 440                 445             

His Met Leu Glu Trp Gln Pro Lys Ile Lys Glu Met Ile Pro Ser Tyr 
    450                 455                 460                 

Gly Val Ser Leu Ala Glu Asn Arg Glu Leu Phe Gln Glu Ile His Gln 
465                 470                 475                 480 

Ser Thr Ala Glu Ala Leu Gly Leu Ser Glu Lys Glu 
                485                 490         

<210>   313
<211>   490
<212>   PRT
<213>   Bacillus thuringiensis str. Al Hakam

<400>   313
Lys Thr Asp Val Ile Leu Ile Gly Ala Gly Ile Met Ser Ala Thr Leu 
                5                   10                  15      

Gly Ser Leu Leu Lys Glu Leu Ala Pro Glu Trp Glu Ile Lys Val Phe 
            20                  25                  30          

Glu Lys Leu Ala Ser Ala Gly Glu Glu Ser Ser Asn Glu Trp Asn Asn 
        35                  40                  45              

Ala Gly Thr Gly His Ser Ala Leu Cys Glu Leu Asn Tyr Thr Ser Glu 
    50                  55                  60                  

Lys Ser Asp Gly Ser Ile Asp Ile Ser Lys Ala Val Lys Val Asn Glu 
65                  70                  75                  80  

Gln Phe Gln Leu Ser Arg Gln Phe Trp Ala Tyr Leu Val Lys Ser Lys 
                85                  90                  95      

Leu Ile Arg Asn Pro Gln Asp Phe Ile Met Pro Leu Pro His Met Ser 
            100                 105                 110         

Leu Val Gln Gly Glu Lys Asn Val Glu Phe Leu Lys Asn Arg Phe Glu 
        115                 120                 125             

Ala Leu Ser Lys Asn Pro Leu Phe Gln Gly Met Glu Phe Ser Asp Ala 
    130                 135                 140                 

Pro Glu Thr Leu Lys Lys Trp Leu Pro Leu Ile Met Glu Gly Arg Thr 
145                 150                 155                 160 

Ser Asn Glu Pro Met Ala Ala Thr Lys Ile Asp Ser Gly Thr Asp Val 
                165                 170                 175     

Asn Phe Gly Ala Leu Thr Arg Met Leu Phe Asp Tyr Leu Gln Thr Lys 
            180                 185                 190         

Asn Val Glu Leu Asn Tyr Lys His Ser Val Glu Asn Ile Lys Arg Thr 
        195                 200                 205             

Lys Asn Gly Leu Trp Glu Val Lys Val His Asp Ile Asn Ser Gly Lys 
    210                 215                 220                 

Ile Glu His His Thr Ala Lys Phe Val Phe Ile Gly Gly Gly Gly Gly 
225                 230                 235                 240 

Ser Leu Pro Leu Leu Gln Lys Thr Gly Ile Pro Glu Ser Lys His Ile 
                245                 250                 255     

Gly Gly Phe Pro Val Ser Gly Leu Phe Met Val Cys Lys Asn Gln Lys 
            260                 265                 270         

Val Val Glu Gln His His Ala Lys Val Tyr Gly Lys Ala Lys Val Gly 
        275                 280                 285             

Ala Pro Pro Met Ser Val Pro His Leu Asp Thr Arg Tyr Ile Asp Asn 
    290                 295                 300                 

Lys Lys Ala Leu Leu Phe Gly Pro Phe Ala Gly Phe Ser Pro Lys Phe 
305                 310                 315                 320 

Leu Lys Thr Gly Ser Asn Leu Asp Leu Ile Gly Ser Val Lys Pro Asn 
                325                 330                 335     

Asn Val Leu Thr Met Leu Ala Ala Gly Val Lys Glu Met Gly Leu Thr 
            340                 345                 350         

Lys Tyr Leu Ile Gln Gln Val Met Leu Ser His Glu Lys Arg Met Glu 
        355                 360                 365             

Glu Leu Arg Glu Phe Ile Pro Asn Ala Lys Ser Glu Asp Trp Asp Ile 
    370                 375                 380                 

Val Val Ala Gly Gln Arg Val Gln Val Ile Lys Asp Thr Asp Ala Gly 
385                 390                 395                 400 

Gly Lys Gly Thr Leu Gln Phe Gly Thr Glu Val Val Ser Ala Ala Asp 
                405                 410                 415     

Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser Pro Gly Ala Ser Thr Ala 
            420                 425                 430         

Val His Val Met Leu Glu Val Leu Glu Lys Cys Phe Pro Ser Arg Met 
        435                 440                 445             

Val Glu Trp Glu Gly Lys Ile Lys Glu Met Ile Pro Ser Tyr Gly Ile 
    450                 455                 460                 

Ser Leu Thr Glu Asn Pro Arg Leu Phe Gln Asp Leu His Thr Ser Thr 
465                 470                 475                 480 

Gly Arg Thr Leu Gly Leu Asn Glu Lys Glu 
                485                 490 

<210>   314
<211>   549
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   314
Met Ile Tyr Thr Leu Tyr Gly Leu Ser Lys Ser Val Glu Arg Cys Gly 
                5                   10                  15      

Asn Arg Ile Ile Ser Ala Arg Gly Arg Ser Ala Arg Arg Arg Met Ser 
            20                  25                  30          

Thr Val Trp Phe Ala Gly Arg Ile Lys Val Arg Pro His Leu His Lys 
        35                  40                  45              

Asp Gly Ile Asp Met Asp Gly Lys Thr Arg Ser Asp Val Ala Leu Ile 
    50                  55                  60                  

Gly Gly Gly Ile Met Ser Ala Thr Leu Gly Thr Leu Phe Arg Gln Leu 
65                  70                  75                  80  

Ala Pro Asp Trp Thr Ile Thr Val Phe Glu Arg Leu Asp Glu Val Ala 
                85                  90                  95      

Val Glu Ser Ser Asn Glu Trp Asn Asn Ala Gly Thr Gly His Ser Ala 
            100                 105                 110         

Leu Cys Glu Leu Asn Tyr Thr Val Glu Gln Pro Asp Gly Ser Ile Asp 
        115                 120                 125             

Ile Ser Lys Ala Ile Gln Val Asn Glu Gln Phe Leu Val Ser Arg Gln 
    130                 135                 140                 

Phe Trp Ser Phe Leu Val Arg Gln Gly Ile Ile Glu His Pro Arg Asp 
145                 150                 155                 160 

Phe Ile Val Pro Val Pro His Met Ser Phe Val Gln Gly Glu Thr Asn 
                165                 170                 175     

Val Ala Phe Leu Lys Lys Arg His Gln Leu Leu Ser Gln His Pro Leu 
            180                 185                 190         

Phe Gln Gly Met Glu Tyr Ser Glu Asp Pro Glu Arg Leu Arg Glu Trp 
        195                 200                 205             

Ile Pro Leu Met Met Lys Asp Arg Lys Leu Asp Arg Pro Ile Ala Ala 
    210                 215                 220                 

Thr Trp Ile Ala Ser Gly Thr Asp Val Asn Phe Gly Ala Leu Thr Arg 
225                 230                 235                 240 

Met Leu Phe Gln Tyr Leu Glu Arg Glu Gly Val Asp Val Gln Cys Gly 
                245                 250                 255     

Lys Glu Val Gln Asp Leu Lys Arg Thr Arg Asp Gly Met Trp Gln Leu 
            260                 265                 270         

Arg Val Arg Asp Val Lys Thr Gly Ala Thr Tyr Glu His Val Ser Lys 
        275                 280                 285             

Phe Val Phe Val Gly Ala Gly Gly Trp Ser Leu Leu Leu Leu Gln Lys 
    290                 295                 300                 

Ser Gly Ile Asp Glu Gly Lys Gly Ile Gly Gly Phe Pro Val Ser Gly 
305                 310                 315                 320 

Leu Phe Met Val Cys Glu Asn Pro Glu Ile Val Arg Gln His Arg Ala 
                325                 330                 335     

Lys Val Tyr Gly Lys Ala Pro Val Gly Ala Pro Pro Met Ser Val Pro 
            340                 345                 350         

His Leu Asp Ser Arg Val Ile Gly Gly Arg Glu Tyr Val Leu Phe Gly 
        355                 360                 365             

Pro Phe Ala Gly Phe Ser Pro Arg Phe Leu Lys Thr Gly Ser Met Leu 
    370                 375                 380                 

Asp Leu Leu Lys Ser Val Lys Leu His Asn Leu Ser Thr Leu Leu Ala 
385                 390                 395                 400 

Ala Gly Ala Lys Asn Ala Ser Leu Thr Leu Tyr Leu Ile Arg Gln Leu 
                405                 410                 415     

Met Leu Thr Lys Lys Gln Arg Met Asp Glu Leu Arg Glu Phe Val Pro 
            420                 425                 430         

Thr Ala Arg Asp Glu Asp Trp Arg Leu Val Val Ala Gly Gln Arg Val 
        435                 440                 445             

Gln Val Ile Lys Arg Arg Pro Arg Gly Glu Leu Gln Phe Gly Thr Glu 
    450                 455                 460                 

Val Val Ser Ala Arg Asp Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser 
465                 470                 475                 480 

Pro Gly Ala Ser Val Val Val Ser Ile Met Leu Glu Val Ile Arg Lys 
                485                 490                 495     

Cys Phe Pro Asp Arg Leu Pro Glu Trp Glu Asn Lys Ile Arg Glu Met 
            500                 505                 510         

Ile Pro Ser Tyr Gly Val Thr Leu Arg His Arg Pro Asp Leu Met Arg 
        515                 520                 525             

Ser Ile Gln Ala Glu Thr Ala Glu Val Leu Gly Leu His Arg Met Glu 
    530                 535                 540                 

Ala Arg Thr Asp Ala 
545                 

<210>   315
<211>   549
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   315
Met Ile Tyr Thr Leu Tyr Gly Leu Ser Lys Ser Val Glu Arg Cys Gly 
                5                   10                  15      

Asn Arg Leu Ile Ser Ala Arg Gly Arg Ser Ala Arg Arg Arg Met Ser 
            20                  25                  30          

Thr Val Trp Phe Ala Gly Arg Ile Lys Val Arg Pro His Leu His Lys 
        35                  40                  45              

Asp Gly Ile Asp Met Asp Gly Lys Thr Arg Ser Asp Val Ala Leu Ile 
    50                  55                  60                  

Gly Gly Gly Ile Met Ser Ala Thr Leu Gly Thr Leu Phe Arg Gln Leu 
65                  70                  75                  80  

Ala Pro Asp Trp Thr Ile Thr Val Phe Glu Arg Leu Asp Glu Val Ala 
                85                  90                  95      

Val Glu Ser Ser Asn Glu Trp Asn Asn Ala Gly Thr Gly His Ser Ala 
            100                 105                 110         

Leu Cys Glu Leu Asn Tyr Thr Val Glu Gln Pro Asp Gly Ser Ile Asp 
        115                 120                 125             

Ile Ser Lys Ala Ile Gln Val Asn Glu Gln Phe Leu Val Ser Arg Gln 
    130                 135                 140                 

Phe Trp Ser Phe Leu Val Arg Gln Gly Ile Ile Glu His Pro Arg Asp 
145                 150                 155                 160 

Phe Ile Val Pro Val Pro His Met Ser Phe Val Gln Gly Glu Thr Asn 
                165                 170                 175     

Val Ala Phe Leu Lys Lys Arg His Gln Leu Leu Ser Gln His Pro Leu 
            180                 185                 190         

Phe Gln Gly Met Glu Tyr Ser Glu Asp Pro Glu Arg Leu Arg Glu Trp 
        195                 200                 205             

Ile Pro Leu Met Met Lys Asp Arg Lys Leu Asp Arg Pro Ile Ala Ala 
    210                 215                 220                 

Thr Trp Ile Ala Ser Gly Thr Asp Val Asn Phe Gly Ala Leu Thr Arg 
225                 230                 235                 240 

Met Leu Phe Gln Tyr Leu Glu Arg Glu Gly Val Asp Val Gln Cys Gly 
                245                 250                 255     

Lys Glu Val Gln Asp Leu Lys Arg Thr Lys Asp Gly Met Trp Gln Leu 
            260                 265                 270         

Arg Val Arg Asp Val Lys Thr Gly Ala Thr Tyr Glu His Val Ser Lys 
        275                 280                 285             

Phe Val Phe Val Gly Ala Gly Gly Trp Ser Leu Leu Leu Leu Gln Lys 
    290                 295                 300                 

Ser Gly Ile Asp Glu Gly Lys Gly Ile Gly Gly Phe Pro Val Ser Gly 
305                 310                 315                 320 

Leu Phe Met Val Cys Glu Asn Pro Glu Ile Val Arg Gln His Arg Ala 
                325                 330                 335     

Lys Val Tyr Gly Lys Ala Pro Val Gly Ala Pro Pro Met Ser Val Pro 
            340                 345                 350         

His Leu Asp Ser Arg Val Ile Gly Gly Arg Glu Tyr Val Leu Phe Gly 
        355                 360                 365             

Pro Phe Ala Gly Phe Ser Pro Arg Phe Leu Lys Thr Gly Ser Met Leu 
    370                 375                 380                 

Asp Leu Leu Lys Ser Val Lys Leu His Asn Leu Ser Thr Leu Leu Ala 
385                 390                 395                 400 

Ala Gly Ala Lys Asn Ala Ser Leu Thr Leu Tyr Leu Ile Arg Gln Leu 
                405                 410                 415     

Met Leu Thr Lys Lys Gln Arg Met Asp Glu Leu Arg Glu Phe Val Pro 
            420                 425                 430         

Thr Ala Arg Asp Glu Asp Trp Arg Leu Val Val Ala Gly Gln Arg Val 
        435                 440                 445             

Gln Val Ile Lys Arg Arg Pro Arg Gly Glu Leu Gln Phe Gly Thr Glu 
    450                 455                 460                 

Val Val Ser Ala Arg Asp Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser 
465                 470                 475                 480 

Pro Gly Ala Ser Val Val Val Ser Ile Met Leu Glu Val Ile Arg Lys 
                485                 490                 495     

Cys Phe Pro Asp Arg Leu Pro Glu Trp Glu Asn Lys Ile Arg Glu Met 
            500                 505                 510         

Ile Pro Ser Tyr Gly Val Thr Leu Arg His Arg Pro Asp Leu Met Arg 
        515                 520                 525             

Ser Ile Gln Ala Glu Thr Ala Glu Val Leu Gly Leu His Arg Met Glu 
    530                 535                 540                 

Ala Arg Thr Asp Ala 
545                 

<210>   316
<211>   549
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   316
Met Ile Tyr Thr Leu Tyr Gly Leu Ser Lys Ser Val Glu Arg Cys Gly 
                5                   10                  15      

Asn Arg Leu Ile Ser Ala Arg Gly Arg Ser Ala Arg Arg Arg Met Ser 
            20                  25                  30          

Thr Val Trp Phe Ala Gly Arg Ile Lys Val Arg Pro His Leu His Lys 
        35                  40                  45              

Asp Gly Ile Asp Met Asp Gly Lys Thr Arg Ser Asp Val Ala Leu Ile 
    50                  55                  60                  

Gly Gly Gly Ile Met Ser Ala Thr Leu Gly Thr Leu Phe Arg Gln Leu 
65                  70                  75                  80  

Ala Pro Asp Trp Thr Ile Thr Val Phe Glu Arg Leu Asp Glu Val Ala 
                85                  90                  95      

Val Glu Ser Ser Asn Glu Trp Asn Asn Ala Gly Thr Gly His Ser Ala 
            100                 105                 110         

Leu Cys Glu Leu Asn Tyr Thr Val Glu Gln Pro Asp Gly Ser Ile Asp 
        115                 120                 125             

Ile Ser Lys Ala Ile Gln Val Asn Glu Gln Phe Leu Val Ser Arg Gln 
    130                 135                 140                 

Phe Trp Ser Phe Leu Val Arg Gln Gly Ile Ile Glu His Pro Arg Asp 
145                 150                 155                 160 

Phe Ile Val Pro Val Pro His Met Ser Phe Val Gln Gly Glu Thr Asn 
                165                 170                 175     

Val Ala Phe Leu Lys Lys Arg His Gln Leu Leu Ser Gln His Pro Leu 
            180                 185                 190         

Phe Gln Gly Met Asp Tyr Ser Glu Asp Pro Glu Arg Leu Arg Glu Trp 
        195                 200                 205             

Ile Pro Leu Met Met Lys Asp Arg Lys Leu Asp Arg Pro Ile Ala Ala 
    210                 215                 220                 

Thr Trp Ile Ala Ser Gly Thr Asp Val Asn Phe Gly Ala Leu Thr Arg 
225                 230                 235                 240 

Met Leu Phe Gln Tyr Leu Glu Arg Glu Gly Val Asp Val Gln Cys Gly 
                245                 250                 255     

Lys Glu Val Gln Asp Leu Lys Arg Thr Arg Asp Gly Met Trp Gln Leu 
            260                 265                 270         

Arg Val Arg Asp Val Lys Thr Gly Ala Thr Tyr Glu His Val Ser Lys 
        275                 280                 285             

Phe Val Phe Val Gly Ala Gly Gly Trp Ser Leu Leu Leu Leu Gln Lys 
    290                 295                 300                 

Ser Gly Ile Asp Glu Gly Lys Gly Ile Gly Gly Phe Pro Val Ser Gly 
305                 310                 315                 320 

Leu Phe Met Val Cys Glu Asn Pro Glu Ile Val Arg Gln His Arg Ala 
                325                 330                 335     

Lys Val Tyr Gly Lys Ala Pro Val Gly Ala Pro Pro Met Ser Val Pro 
            340                 345                 350         

His Leu Asp Ser Arg Val Ile Gly Gly Arg Glu Tyr Val Leu Phe Gly 
        355                 360                 365             

Pro Phe Ala Gly Phe Ser Pro Arg Phe Leu Lys Thr Gly Ser Met Leu 
    370                 375                 380                 

Asp Leu Leu Lys Ser Val Lys Leu His Asn Leu Ser Thr Leu Leu Ala 
385                 390                 395                 400 

Ala Gly Ala Lys Asn Ala Ser Leu Thr Leu Tyr Leu Ile Arg Gln Leu 
                405                 410                 415     

Met Leu Thr Lys Lys Gln Arg Met Asp Glu Leu Arg Glu Phe Val Pro 
            420                 425                 430         

Thr Ala Arg Asp Glu Asp Trp Arg Leu Val Val Ala Gly Gln Arg Val 
        435                 440                 445             

Gln Val Ile Lys Arg Arg Pro Arg Gly Glu Leu Gln Phe Gly Thr Glu 
    450                 455                 460                 

Val Val Ser Ala Arg Asp Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser 
465                 470                 475                 480 

Pro Gly Ala Ser Val Val Val Ser Ile Met Leu Glu Val Ile Arg Lys 
                485                 490                 495     

Cys Phe Pro Asp Arg Leu Pro Glu Trp Glu Asn Lys Ile Arg Glu Met 
            500                 505                 510         

Ile Pro Ser Tyr Gly Val Thr Leu Arg His Arg Pro Asp Leu Met Arg 
        515                 520                 525             

Ser Ile Gln Ala Glu Thr Ala Glu Val Leu Gly Leu His Arg Met Glu 
    530                 535                 540                 

Ala Arg Thr Asp Ala 
545                 

<210>   317
<211>   549
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   317
Met Ile Tyr Thr Leu Tyr Gly Leu Ser Lys Ser Val Glu Arg Cys Gly 
                5                   10                  15      

Asn Arg Leu Ile Ser Ala Arg Gly Arg Ser Ala Arg Arg Arg Met Ser 
            20                  25                  30          

Thr Val Trp Phe Ala Gly Arg Ile Lys Val Arg Pro His Leu His Lys 
        35                  40                  45              

Asp Gly Ile Asp Met Asp Gly Lys Thr Arg Ser Asp Val Ala Leu Ile 
    50                  55                  60                  

Gly Gly Gly Ile Met Ser Ala Thr Leu Gly Thr Leu Phe Arg Gln Leu 
65                  70                  75                  80  

Ala Pro Asp Trp Thr Ile Thr Val Phe Glu Arg Leu Asp Glu Val Ala 
                85                  90                  95      

Val Glu Ser Ser Asn Glu Trp Asn Asn Ala Gly Thr Gly His Ser Ala 
            100                 105                 110         

Leu Cys Glu Leu Asn Tyr Thr Val Glu Gln Pro Asp Gly Ser Ile Asp 
        115                 120                 125             

Ile Ser Lys Ala Ile Gln Val Asn Glu Gln Phe Leu Val Ser Arg Gln 
    130                 135                 140                 

Phe Trp Ser Phe Leu Val Arg Gln Gly Ile Ile Glu His Pro Arg Asp 
145                 150                 155                 160 

Phe Ile Val Pro Val Pro His Met Ser Phe Val Gln Gly Glu Thr Asn 
                165                 170                 175     

Val Ala Phe Leu Lys Lys Arg His Gln Leu Leu Ser Gln His Pro Leu 
            180                 185                 190         

Phe Gln Gly Met Glu Tyr Ser Glu Asp Pro Glu Arg Leu Arg Glu Trp 
        195                 200                 205             

Ile Pro Leu Met Met Lys Asp Arg Lys Leu Asp Arg Pro Ile Ala Ala 
    210                 215                 220                 

Thr Trp Ile Ala Ser Gly Thr Asp Val Asn Phe Gly Ala Leu Thr Arg 
225                 230                 235                 240 

Met Leu Phe Gln Tyr Leu Glu Arg Glu Gly Val Asp Val Gln Cys Gly 
                245                 250                 255     

Lys Glu Val Gln Asp Leu Lys Arg Thr Arg Asp Gly Met Trp Gln Leu 
            260                 265                 270         

Arg Val Arg Asp Val Lys Thr Gly Ala Thr Tyr Glu His Val Ser Lys 
        275                 280                 285             

Phe Val Phe Val Gly Ala Gly Gly Trp Ser Leu Leu Leu Leu Gln Lys 
    290                 295                 300                 

Ser Gly Ile Asp Glu Gly Lys Gly Ile Gly Gly Phe Pro Val Ser Gly 
305                 310                 315                 320 

Leu Phe Met Val Cys Glu Asn Pro Glu Ile Val Arg Gln His Arg Ala 
                325                 330                 335     

Lys Val Tyr Gly Lys Ala Pro Val Gly Ala Pro Pro Met Ser Val Pro 
            340                 345                 350         

His Leu Asp Ser Arg Ile Ile Gly Gly Arg Glu Tyr Val Leu Phe Gly 
        355                 360                 365             

Pro Phe Ala Gly Phe Ser Pro Arg Phe Leu Lys Thr Gly Ser Met Leu 
    370                 375                 380                 

Asp Leu Leu Lys Ser Val Lys Leu His Asn Leu Ser Thr Leu Leu Ala 
385                 390                 395                 400 

Ala Gly Ala Lys Asn Ala Ser Leu Thr Leu Tyr Leu Ile Arg Gln Leu 
                405                 410                 415     

Met Leu Thr Lys Lys Gln Arg Met Asp Glu Leu Arg Glu Phe Val Pro 
            420                 425                 430         

Thr Ala Arg Asp Glu Asp Trp Arg Leu Val Val Ala Gly Gln Arg Val 
        435                 440                 445             

Gln Val Ile Lys Arg Arg Pro Arg Gly Glu Leu Gln Phe Gly Thr Glu 
    450                 455                 460                 

Val Val Ser Ala Arg Asp Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser 
465                 470                 475                 480 

Pro Gly Ala Ser Val Val Val Ser Ile Met Leu Glu Val Ile Arg Lys 
                485                 490                 495     

Cys Phe Pro Asp Arg Leu Pro Glu Trp Glu Asn Lys Ile Arg Glu Met 
            500                 505                 510         

Ile Pro Ser Tyr Gly Val Thr Leu Arg His Arg Pro Asp Leu Met Arg 
        515                 520                 525             

Ser Ile Gln Ala Glu Thr Ala Glu Val Leu Gly Leu His Arg Met Glu 
    530                 535                 540                 

Ala Arg Thr Asp Ala 
545                 

<210>   318
<211>   549
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   318
Met Ile Tyr Thr Leu Tyr Gly Leu Ser Lys Ser Val Glu Arg Cys Gly 
                5                   10                  15      

Asn Arg Leu Ile Ser Ala Arg Gly Arg Ser Ala Arg Arg Arg Met Ser 
            20                  25                  30          

Thr Val Trp Phe Ala Gly Arg Ile Arg Val Arg Pro His Leu His Lys 
        35                  40                  45              

Asp Gly Ile Asp Met Asp Gly Lys Thr Arg Ser Asp Val Ala Leu Ile 
    50                  55                  60                  

Gly Gly Gly Ile Met Ser Ala Thr Leu Gly Thr Leu Phe Arg Gln Leu 
65                  70                  75                  80  

Ala Pro Asp Trp Thr Ile Thr Val Phe Glu Arg Leu Asp Glu Val Ala 
                85                  90                  95      

Val Glu Ser Ser Asn Glu Trp Asn Asn Ala Gly Thr Gly His Ser Ala 
            100                 105                 110         

Leu Cys Glu Leu Asn Tyr Thr Val Glu Gln Pro Asp Gly Ser Ile Asp 
        115                 120                 125             

Ile Ser Lys Ala Ile Gln Val Asn Glu Gln Phe Leu Val Ser Arg Gln 
    130                 135                 140                 

Phe Trp Ser Phe Leu Val Arg Gln Gly Ile Ile Glu His Pro Arg Asp 
145                 150                 155                 160 

Phe Ile Val Pro Val Pro His Met Ser Phe Val Gln Gly Glu Thr Asn 
                165                 170                 175     

Val Ala Phe Leu Lys Lys Arg His Gln Leu Leu Ser Gln His Pro Leu 
            180                 185                 190         

Phe Gln Gly Met Glu Tyr Ser Glu Asp Pro Glu Arg Leu Arg Glu Trp 
        195                 200                 205             

Ile Pro Leu Met Met Lys Asp Arg Lys Leu Asp Arg Pro Ile Ala Ala 
    210                 215                 220                 

Thr Trp Ile Ala Ser Gly Thr Asp Val Asn Phe Gly Ala Leu Thr Arg 
225                 230                 235                 240 

Met Leu Phe Gln Tyr Leu Glu Arg Glu Gly Val Asp Val Gln Cys Gly 
                245                 250                 255     

Lys Glu Val Gln Asp Leu Lys Arg Thr Arg Asp Gly Met Trp Gln Leu 
            260                 265                 270         

Arg Val Arg Asp Val Lys Thr Gly Ala Thr Tyr Glu His Val Ser Lys 
        275                 280                 285             

Phe Val Phe Val Gly Ala Gly Gly Trp Ser Leu Leu Leu Leu Gln Lys 
    290                 295                 300                 

Ser Gly Ile Asp Glu Gly Lys Gly Ile Gly Gly Phe Pro Val Ser Gly 
305                 310                 315                 320 

Leu Phe Met Val Cys Glu Asn Pro Glu Ile Val Arg Gln His Arg Ala 
                325                 330                 335     

Lys Val Tyr Gly Lys Ala Pro Val Gly Ala Pro Pro Met Ser Val Pro 
            340                 345                 350         

His Leu Asp Ser Arg Val Ile Gly Gly Arg Glu Tyr Val Leu Phe Gly 
        355                 360                 365             

Pro Phe Ala Gly Phe Ser Pro Arg Phe Leu Lys Thr Gly Ser Met Leu 
    370                 375                 380                 

Asp Leu Leu Lys Ser Val Lys Leu His Asn Leu Ser Thr Leu Leu Ala 
385                 390                 395                 400 

Ala Gly Ala Lys Asn Ala Ser Leu Thr Leu Tyr Leu Ile Arg Gln Leu 
                405                 410                 415     

Met Leu Thr Lys Lys Gln Arg Met Asp Glu Leu Arg Glu Phe Val Pro 
            420                 425                 430         

Thr Ala Arg Asp Glu Asp Trp Arg Leu Val Val Ala Gly Gln Arg Val 
        435                 440                 445             

Gln Val Ile Lys Arg Arg Pro Arg Gly Glu Leu Gln Phe Gly Thr Glu 
    450                 455                 460                 

Val Val Ser Ala Arg Asp Gly Ser Ile Ala Ala Leu Leu Gly Ala Ser 
465                 470                 475                 480 

Pro Gly Ala Ser Val Val Val Ser Ile Met Leu Glu Val Ile Arg Lys 
                485                 490                 495     

Cys Phe Pro Asp Arg Leu Pro Glu Trp Glu Asn Lys Ile Arg Glu Met 
            500                 505                 510         

Ile Pro Ser Tyr Gly Val Thr Leu Arg His Arg Pro Asp Leu Met Arg 
        515                 520                 525             

Ser Ile Gln Ala Glu Thr Ala Glu Val Leu Gly Leu His Arg Met Glu 
    530                 535                 540                 

Ala Arg Thr Asp Ala 
545                 

<210>   319
<211>   1650
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   319
atgatttata ctctatacgg gttgtcgaaa tccgttgaac ggtgcggaaa ccgcattatt       60

tcggcgcgcg gacgttcagc gcggcgccga atgtcgacag tttggtttgc ggggcgcatc      120

aaggtgcgcc cgcatctgca taaggatggg atcgacatgg acggaaagac gagatcggat      180

gtcgccctga ttggcggcgg catcatgagt gccacgctgg ggaccttgtt tcggcagctt      240

gcgcccgatt ggaccatcac cgtgttcgaa cgcctcgacg aggtcgcggt ggagagttcg      300

aacgagtgga acaacgcggg cacggggcac tctgcgctct gcgagctgaa ctacacggtc      360

gaacagccag acggaagcat cgacatctcc aaggccattc aggtgaacga gcagttcctg      420

gtctctcgcc aattttggtc gttcctcgtg cgacagggca tcatcgaaca tccgagagat      480

tttatcgtgc ctgtgccgca catgagcttc gtgcagggcg agacgaacgt ggcgtttttg      540

aagaaacggc accagttgtt gtcccagcac ccgcttttcc aagggatgga atactccgag      600

gatcccgagc ggctccggga atggattccg ctgatgatga aggatcgcaa gctggatcgc      660

ccgattgccg ctacgtggat cgcgtccggc acggacgtga acttcggcgc gctcacccgg      720

atgctgttcc aatacctgga gcgcgaaggc gtggacgttc agtgcggcaa agaggtccag      780

gacttgaagc gtacgcgcga cggcatgtgg cagctccgcg tgcgcgatgt gaagacgggc      840

gccacctatg agcatgtgtc gaagttcgtc ttcgtcgggg ccgggggatg gagtctactg      900

cttctgcaga aatccggcat tgacgagggg aagggcatcg gtggcttccc ggtgagcggt      960

cttttcatgg tctgcgagaa tcccgagatt gtccgccagc accgcgccaa ggtgtatggc     1020

aaggcccccg tgggtgcgcc tcccatgtcc gtgccgcacc tggattctcg cgtcatcggc     1080

ggccgagagt atgtcctgtt cgggccgttc gccgggtttt caccgcgctt tttgaagacg     1140

ggctccatgc tcgacctact gaagtcggtc aagcttcaca acctgtcgac cctgctcgcc     1200

gcgggcgcca agaacgcctc gctgacgctg tatctcatcc gacagctcat gctgacgaaa     1260

aagcagcgca tggacgagct gcgcgagttc gtgcccacgg cacgtgatga ggattggcgc     1320

ctcgttgtcg cgggccaacg cgtccaggtc atcaagcggc gcccgcgagg cgagctgcag     1380

ttcggcaccg aggtggtgag cgccagggac ggatccatcg ctgcgctgct cggcgcatcg     1440

ccgggcgcgt cggtcgtggt gtccatcatg ctcgaggtca tccgcaaatg tttcccggac     1500

cggctgcccg agtgggagaa caagatccgc gagatgatcc cgtcgtacgg cgtcacgctg     1560

cgccacagac ccgatctgat gcgttccatc caggccgaga cggccgaggt gctggggctg     1620

catcggatgg aggcccgaac ggacgcgtga                                      1650


<210>   320
<211>   1650
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   320
atgatttata ctctatacgg gttgtcgaaa tccgttgaac ggtgcggaaa ccgcttgatt       60

tcggcgcgcg gacgttcagc gcggcgccga atgtcgacag tttggtttgc ggggcgcatc      120

aaggtgcgcc cgcatctgca taaggatggg atcgacatgg acggaaagac gagatcggat      180

gtcgccctga ttggcggcgg catcatgagt gccacgctgg ggaccttgtt tcggcagctt      240

gcgcccgatt ggaccatcac cgtgttcgaa cgcctcgacg aggtcgcggt ggagagttcg      300

aacgagtgga acaacgcggg cacggggcac tctgcgctct gcgagctgaa ctacacggtc      360

gaacagccag acggaagcat cgacatctcc aaggccattc aggtgaacga gcagttcctg      420

gtctctcgcc aattttggtc gttcctcgtg cgacagggca tcatcgaaca tccgagagat      480

tttatcgtgc ctgtgccgca catgagcttc gtgcagggcg agacgaacgt ggcgtttttg      540

aagaaacggc accagttgtt gtcccagcac ccgcttttcc aagggatgga atactccgag      600

gatcccgagc ggctccggga atggattccg ctgatgatga aggatcgcaa gctggatcgc      660

ccgattgccg ctacgtggat cgcgtccggc acggacgtga acttcggcgc gctcacccgg      720

atgctgttcc aatacctgga gcgcgaaggc gtggacgttc agtgcggcaa agaggtccag      780

gacttgaagc gtacgaaaga cggcatgtgg cagctccgcg tgcgcgatgt gaagacgggc      840

gccacctatg agcatgtgtc gaagttcgtc ttcgtcgggg ccgggggatg gagtctactg      900

cttctgcaga aatccggcat tgacgagggg aagggcatcg gtggcttccc ggtgagcggt      960

cttttcatgg tctgcgagaa tcccgagatt gtccgccagc accgcgccaa ggtgtatggc     1020

aaggcccccg tgggtgcgcc tcccatgtcc gtgccgcacc tggattctcg cgtcatcggc     1080

ggccgagagt atgtcctgtt cgggccgttc gccgggtttt caccgcgctt tttgaagacg     1140

ggctccatgc tcgacctact gaagtcggtc aagcttcaca acctgtcgac cctgctcgcc     1200

gcgggcgcca agaacgcctc gctgacgctg tatctcatcc gacagctcat gctgacgaaa     1260

aagcagcgca tggacgagct gcgcgagttc gtgcccacgg cacgtgatga ggattggcgc     1320

ctcgttgtcg cgggccaacg cgtccaggtc atcaagcggc gcccgcgagg cgagctgcag     1380

ttcggcaccg aggtggtgag cgccagggac ggatccatcg ctgcgctgct cggcgcatcg     1440

ccgggcgcgt cggtcgtggt gtccatcatg ctcgaggtca tccgcaaatg tttcccggac     1500

cggctgcccg agtgggagaa caagatccgc gagatgatcc cgtcgtacgg cgtcacgctg     1560

cgccacagac ccgatctgat gcgttccatc caggccgaga cggccgaggt gctggggctg     1620

catcggatgg aggcccgaac ggacgcgtga                                      1650


<210>   321
<211>   1650
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   321
atgatttata ctctatacgg gttgtcgaaa tccgttgaac ggtgcggaaa ccgcttgatt       60

tcggcgcgcg gacgttcagc gcggcgccga atgtcgacag tttggtttgc ggggcgcatc      120

aaggtgcgcc cgcatctgca taaggatggg atcgacatgg acggaaagac gagatcggat      180

gtcgccctga ttggcggcgg catcatgagt gccacgctgg ggaccttgtt tcggcagctt      240

gcgcccgatt ggaccatcac cgtgttcgaa cgcctcgacg aggtcgcggt ggagagttcg      300

aacgagtgga acaacgcggg cacggggcac tctgcgctct gcgagctgaa ctacacggtc      360

gaacagccag acggaagcat cgacatctcc aaggccattc aggtgaacga gcagttcctg      420

gtctctcgcc aattttggtc gttcctcgtg cgacagggca tcatcgaaca tccgagagat      480

tttatcgtgc ctgtgccgca catgagcttc gtgcagggcg agacgaacgt ggcgtttttg      540

aagaaacggc accagttgtt gtcccagcac ccgcttttcc aagggatgga ttactccgag      600

gatcccgagc ggctccggga atggattccg ctgatgatga aggatcgcaa gctggatcgc      660

ccgattgccg ctacgtggat cgcgtccggc acggacgtga acttcggcgc gctcacccgg      720

atgctgttcc aatacctgga gcgcgaaggc gtggacgttc agtgcggcaa agaggtccag      780

gacttgaagc gtacgcgcga cggcatgtgg cagctccgcg tgcgcgatgt gaagacgggc      840

gccacctatg agcatgtgtc gaagttcgtc ttcgtcgggg ccgggggatg gagtctactg      900

cttctgcaga aatccggcat tgacgagggg aagggcatcg gtggcttccc ggtgagcggt      960

cttttcatgg tctgcgagaa tcccgagatt gtccgccagc accgcgccaa ggtgtatggc     1020

aaggcccccg tgggtgcgcc tcccatgtcc gtgccgcacc tggattctcg cgtcatcggc     1080

ggccgagagt atgtcctgtt cgggccgttc gccgggtttt caccgcgctt tttgaagacg     1140

ggctccatgc tcgacctact gaagtcggtc aagcttcaca acctgtcgac cctgctcgcc     1200

gcgggcgcca agaacgcctc gctgacgctg tatctcatcc gacagctcat gctgacgaaa     1260

aagcagcgca tggacgagct gcgcgagttc gtgcccacgg cacgtgatga ggattggcgc     1320

ctcgttgtcg cgggccaacg cgtccaggtc atcaagcggc gcccgcgagg cgagctgcag     1380

ttcggcaccg aggtggtgag cgccagggac ggatccatcg ctgcgctgct cggcgcatcg     1440

ccgggcgcgt cggtcgtggt gtccatcatg ctcgaggtca tccgcaaatg tttcccggac     1500

cggctgcccg agtgggagaa caagatccgc gagatgatcc cgtcgtacgg cgtcacgctg     1560

cgccacagac ccgatctgat gcgttccatc caggccgaga cggccgaggt gctggggctg     1620

catcggatgg aggcccgaac ggacgcgtga                                      1650


<210>   322
<211>   1650
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   322
atgatttata ctctatacgg gttgtcgaaa tccgttgaac ggtgcggaaa ccgcttgatt       60

tcggcgcgcg gacgttcagc gcggcgccga atgtcgacag tttggtttgc ggggcgcatc      120

aaggtgcgcc cgcatctgca taaggatggg atcgacatgg acggaaagac gagatcggat      180

gtcgccctga ttggcggcgg catcatgagt gccacgctgg ggaccttgtt tcggcagctt      240

gcgcccgatt ggaccatcac cgtgttcgaa cgcctcgacg aggtcgcggt ggagagttcg      300

aacgagtgga acaacgcggg cacggggcac tctgcgctct gcgagctgaa ctacacggtc      360

gaacagccag acggaagcat cgacatctcc aaggccattc aggtgaacga gcagttcctg      420

gtctctcgcc aattttggtc gttcctcgtg cgacagggca tcatcgaaca tccgagagat      480

tttatcgtgc ctgtgccgca catgagcttc gtgcagggcg agacgaacgt ggcgtttttg      540

aagaaacggc accagttgtt gtcccagcac ccgcttttcc aagggatgga atactccgag      600

gatcccgagc ggctccggga atggattccg ctgatgatga aggatcgcaa gctggatcgc      660

ccgattgccg ctacgtggat cgcgtccggc acggacgtga acttcggcgc gctcacccgg      720

atgctgttcc aatacctgga gcgcgaaggc gtggacgttc agtgcggcaa agaggtccag      780

gacttgaagc gtacgcgcga cggcatgtgg cagctccgcg tgcgcgatgt gaagacgggc      840

gccacctatg agcatgtgtc gaagttcgtc ttcgtcgggg ccgggggatg gagtctactg      900

cttctgcaga aatccggcat tgacgagggg aagggcatcg gtggcttccc ggtgagcggt      960

cttttcatgg tctgcgagaa tcccgagatt gtccgccagc accgcgccaa ggtgtatggc     1020

aaggcccccg tgggtgcgcc tcccatgtcc gtgccgcacc tggattctcg cattatcggc     1080

ggccgagagt atgtcctgtt cgggccgttc gccgggtttt caccgcgctt tttgaagacg     1140

ggctccatgc tcgacctact gaagtcggtc aagcttcaca acctgtcgac cctgctcgcc     1200

gcgggcgcca agaacgcctc gctgacgctg tatctcatcc gacagctcat gctgacgaaa     1260

aagcagcgca tggacgagct gcgcgagttc gtgcccacgg cacgtgatga ggattggcgc     1320

ctcgttgtcg cgggccaacg cgtccaggtc atcaagcggc gcccgcgagg cgagctgcag     1380

ttcggcaccg aggtggtgag cgccagggac ggatccatcg ctgcgctgct cggcgcatcg     1440

ccgggcgcgt cggtcgtggt gtccatcatg ctcgaggtca tccgcaaatg tttcccggac     1500

cggctgcccg agtgggagaa caagatccgc gagatgatcc cgtcgtacgg cgtcacgctg     1560

cgccacagac ccgatctgat gcgttccatc caggccgaga cggccgaggt gctggggctg     1620

catcggatgg aggcccgaac ggacgcgtga                                      1650


<210>   323
<211>   1650
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   323
atgatttata ctctatacgg gttgtcgaaa tccgttgaac ggtgcggaaa ccgcttgatt       60

tcggcgcgcg gacgttcagc gcggcgccga atgtcgacag tttggtttgc ggggcgcatc      120

cgtgtgcgcc cgcatctgca taaggatggg atcgacatgg acggaaagac gagatcggat      180

gtcgccctga ttggcggcgg catcatgagt gccacgctgg ggaccttgtt tcggcagctt      240

gcgcccgatt ggaccatcac cgtgttcgaa cgcctcgacg aggtcgcggt ggagagttcg      300

aacgagtgga acaacgcggg cacggggcac tctgcgctct gcgagctgaa ctacacggtc      360

gaacagccag acggaagcat cgacatctcc aaggccattc aggtgaacga gcagttcctg      420

gtctctcgcc aattttggtc gttcctcgtg cgacagggca tcatcgaaca tccgagagat      480

tttatcgtgc ctgtgccgca catgagcttc gtgcagggcg agacgaacgt ggcgtttttg      540

aagaaacggc accagttgtt gtcccagcac ccgcttttcc aagggatgga atactccgag      600

gatcccgagc ggctccggga atggattccg ctgatgatga aggatcgcaa gctggatcgc      660

ccgattgccg ctacgtggat cgcgtccggc acggacgtga acttcggcgc gctcacccgg      720

atgctgttcc aatacctgga gcgcgaaggc gtggacgttc agtgcggcaa agaggtccag      780

gacttgaagc gtacgcgcga cggcatgtgg cagctccgcg tgcgcgatgt gaagacgggc      840

gccacctatg agcatgtgtc gaagttcgtc ttcgtcgggg ccgggggatg gagtctactg      900

cttctgcaga aatccggcat tgacgagggg aagggcatcg gtggcttccc ggtgagcggt      960

cttttcatgg tctgcgagaa tcccgagatt gtccgccagc accgcgccaa ggtgtatggc     1020

aaggcccccg tgggtgcgcc tcccatgtcc gtgccgcacc tggattctcg cgtcatcggc     1080

ggccgagagt atgtcctgtt cgggccgttc gccgggtttt caccgcgctt tttgaagacg     1140

ggctccatgc tcgacctact gaagtcggtc aagcttcaca acctgtcgac cctgctcgcc     1200

gcgggcgcca agaacgcctc gctgacgctg tatctcatcc gacagctcat gctgacgaaa     1260

aagcagcgca tggacgagct gcgcgagttc gtgcccacgg cacgtgatga ggattggcgc     1320

ctcgttgtcg cgggccaacg cgtccaggtc atcaagcggc gcccgcgagg cgagctgcag     1380

ttcggcaccg aggtggtgag cgccagggac ggatccatcg ctgcgctgct cggcgcatcg     1440

ccgggcgcgt cggtcgtggt gtccatcatg ctcgaggtca tccgcaaatg tttcccggac     1500

cggctgcccg agtgggagaa caagatccgc gagatgatcc cgtcgtacgg cgtcacgctg     1560

cgccacagac ccgatctgat gcgttccatc caggccgaga cggccgaggt gctggggctg     1620

catcggatgg aggcccgaac ggacgcgtga                                      1650


<210>   324
<211>   474
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   324
Met Glu Phe Gln Arg Ser Gly Ile Ser Leu Ile Tyr Arg Leu Glu Ile 
                5                   10                  15      

Ala Asn Lys Gly Asn Thr Phe Ala Lys Val Ala Ser Leu Val Gly Asn 
            20                  25                  30          

Ala Gly Gly Asp Ile Ala Ala Val Asp Val Ile Arg Val Thr Gln Asp 
        35                  40                  45              

Val Val Val Arg Asp Val Thr Ile Asn Val Ala Asn Arg Glu His Gly 
    50                  55                  60                  

Arg Gln Ile Ala Glu Leu Leu Asp Ala Glu Pro Gly Ile His Val Val 
65                  70                  75                  80  

Ala Val Ser Asp Arg Thr Phe Leu Val His Leu Gly Gly Lys Leu Glu 
                85                  90                  95      

Val Val Pro Lys Ile Gln Val Lys Asn Arg Glu Asp Leu Ser Arg Val 
            100                 105                 110         

Tyr Thr Pro His Val Ala Arg Val Cys Glu Ala Ile His Glu Asp Pro 
        115                 120                 125             

Ser Lys Ala Phe Gln Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val 
    130                 135                 140                 

Ser Asp Gly Thr Ala Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala 
145                 150                 155                 160 

Ala Met Pro Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala 
                165                 170                 175     

Gly Val Asp Ala Phe Pro Ile Cys Leu Asp Thr Lys Asp Pro Asp Glu 
            180                 185                 190         

Ile Val Glu Thr Val Lys Arg Ile Ala Pro Ala Phe Gly Gly Ile Asn 
        195                 200                 205             

Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe Tyr Ile Glu Glu Arg Leu 
    210                 215                 220                 

Lys Gln Glu Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr 
225                 230                 235                 240 

Ala Val Val Met Leu Ala Gly Leu Met Asn Ala Ala Lys Leu Val Gly 
                245                 250                 255     

Lys Lys Leu Gln Asp Leu Lys Val Val Ile Val Gly Ile Gly Ala Ala 
            260                 265                 270         

Gly Val Ala Cys Thr Lys Met Leu Leu Ser Ala Gly Val Lys Asn Ile 
        275                 280                 285             

Ile Gly Val Thr Leu Glu Gly Ile Leu His Arg Gly Lys Gln Tyr Asp 
    290                 295                 300                 

Asn Glu Ile Trp Asn Trp Tyr Lys Glu His Thr Asn Pro Asp Asn Ile 
305                 310                 315                 320 

Thr Gly Thr Leu Asp Asp Ala Ile Val Gly Ala Asp Val Phe Ile Gly 
                325                 330                 335     

Val Ser Gly Pro Gly Val Leu Thr Val Asp His Ile Lys Lys Met Ala 
            340                 345                 350         

Pro Asp Pro Ile Val Phe Ala Met Ala Asn Pro Thr Pro Glu Ile Glu 
        355                 360                 365             

Pro Glu Leu Ala Ala Pro His Val Arg Val Leu Ala Thr Gly Arg Ser 
    370                 375                 380                 

Asp Tyr Pro Asn Gln Ile Asn Asn Leu Leu Cys Phe Pro Gly Met Phe 
385                 390                 395                 400 

Lys Gly Ala Leu Ala Ala Arg Ala Ser Thr Ile Asn Glu Glu Met Lys 
                405                 410                 415     

Leu Ala Ala Ala Gln Ala Ile Ala Ser Ile Ile Arg Glu Asn Glu Leu 
            420                 425                 430         

Arg Glu Asp Tyr Ile Ile Pro Ser Val Phe Asn Gln Ala Val Val Gln 
        435                 440                 445             

Arg Val Ala Asp Ala Val Ala Asp Ala Ala Arg Arg Thr Gly Val Ala 
    450                 455                 460                 

Arg Arg Glu Val Met Pro Lys Asp Asn Tyr 
465                 470                 

<210>   325
<211>   1425
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   325
atggagtttc agcggagtgg catcagtctg atttatcgac tggagatcgc caataagggc       60

aacacgtttg cgaaggtggc gagcctggtc gggaacgctg gaggcgatat tgctgcggtc      120

gacgtgatcc gcgtgacgca ggacgtggtg gtgcgagacg tgaccatcaa cgtggcgaat      180

cgcgagcatg gccgccagat cgccgagttg ctcgacgcgg agccggggat ccacgtggtg      240

gcggtgtccg accggacctt cctcgttcac ttgggcggca agctcgaagt tgtgccgaag      300

atccaggtga agaaccgcga ggatctttcg cgcgtgtaca cgccgcacgt ggcgcgcgtg      360

tgcgaggcga ttcacgagga cccgtccaag gcgttccaac tgaccatcaa gcgcaacacg      420

gtggccgtgg tctcggacgg cacggcggtg ttgggcctcg gggacatcgg cccgtacgcg      480

gcgatgccgg tcatggaagg caaggccatg ctgttcaaac agttcgcagg cgtggacgcg      540

ttccccatct gcctcgacac gaaggatccg gacgagatcg tcgagacggt gaagcgcatc      600

gcgccggcgt ttggcggcat caatctggag gatatctcgt ctccgagatg cttctatatc      660

gaggagcggc tgaagcagga gctcgacatc cctgtcttcc acgacgacca acacgggacg      720

gcggtcgtca tgctggccgg cctgatgaac gcggcgaagc tcgtcgggaa gaagcttcag      780

gacctcaagg tcgtgatcgt cggcatcggc gctgcgggcg tggcctgcac gaaaatgctc      840

ttgtccgccg gtgtgaaaaa catcatcggc gtcacgctgg agggcatcct gcaccgcggc      900

aagcagtacg acaacgagat ctggaattgg tacaaggagc acacgaatcc ggacaacatc      960

acgggcacgc tggacgacgc catcgtgggc gcggacgtgt tcatcggcgt gtcgggacct     1020

ggcgtgctga cggtcgatca catcaagaag atggcgcccg atccgattgt cttcgcgatg     1080

gccaacccga cgccggagat cgagccggaa ctggcggctc cccatgtgcg cgtgctcgcc     1140

accggtcgat ccgactaccc gaaccagatc aacaacctcc tctgtttccc gggcatgttc     1200

aagggggcgc tggcggcgcg cgcgtcgacc atcaacgagg agatgaagct cgcggctgcg     1260

caggccattg cttccatcat ccgtgagaac gagttgcgcg aggactacat tattccgtct     1320

gtctttaacc aagcggttgt tcagcgagtc gcggacgcgg tcgccgatgc cgcccgccga     1380

acgggcgtgg cgcgccgcga agtgatgccg aaggacaact attga                     1425


<210>   326
<211>   438
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   326
Ala Ser Met Arg Ile Ile Val Arg Leu Glu Ile Glu Asn Thr Gly Ser 
                5                   10                  15      

Ile Phe Ser Tyr Ile Ala Thr Ala Ile Gly Ala Ser Gly Gly Asp Ile 
            20                  25                  30          

Val Ala Val Asp Leu Ile Gln Ser Arg Arg Asp Val Val Val Arg Asp 
        35                  40                  45              

Ile Thr Ile Ala Val Glu Asn Arg Ala His Gly Asp Arg Ile Val Gln 
    50                  55                  60                  

Ala Leu Ala Ala Leu Pro Gly Val Lys Val Val Asn Val Ser Asp Arg 
65                  70                  75                  80  

Ile Phe Leu Ala His Leu Gly Gly Lys Ile Glu Val Lys Pro Arg Val 
                85                  90                  95      

Gln Val Lys Thr Arg Asp Asp Leu Ser Val Val Tyr Thr Pro Gly Val 
            100                 105                 110         

Ala Asp Val Cys Arg Ala Ile Ala Glu Asp Pro Ala Lys Ala Phe Thr 
        115                 120                 125             

Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val Thr Asp Gly Thr Ala 
    130                 135                 140                 

Val Leu Gly Leu Gly Asn Ile Gly Pro Ala Ala Ala Leu Pro Val Met 
145                 150                 155                 160 

Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala Gly Val Asp Ala Phe 
                165                 170                 175     

Pro Ile Cys Leu Asp Thr Thr Asp Pro Asp Glu Ile Val Arg Ile Val 
            180                 185                 190         

Lys Ala Ile Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser 
        195                 200                 205             

Ser Pro Arg Cys Phe Glu Ile Glu Glu Arg Leu Lys Glu Glu Leu Asp 
    210                 215                 220                 

Ile Pro Val Phe His Asp Asp Gln His Gly Thr Ala Val Val Val Leu 
225                 230                 235                 240 

Ala Gly Leu Met Asn Ala Ala Arg Val Val Gly Lys Glu Leu Ala Asp 
                245                 250                 255     

Leu Arg Val Val Val Cys Gly Ile Gly Ala Ala Gly Val Ala Ile Ser 
            260                 265                 270         

Lys Met Leu Met Ala Ala Gly Ile Thr Asn Ile Val Gly Val Asp Arg 
        275                 280                 285             

Val Gly Ile Ile Glu Arg Gly Lys Thr Tyr Glu Asn Pro Met Trp Gln 
    290                 295                 300                 

Trp Tyr Ala Glu His Thr Asn Pro Glu Asn Arg His Gly Thr Leu Asp 
305                 310                 315                 320 

Asp Ala Ile Glu Gly Ala Asp Ala Phe Ile Gly Val Ser Ala Pro Asn 
                325                 330                 335     

Val Leu Lys Val Glu His Val Lys Lys Met Ala Lys Asp Pro Ile Val 
            340                 345                 350         

Phe Ala Met Ala Asn Pro Val Pro Glu Ile Asp Pro Asp Glu Ala Ala 
        355                 360                 365             

Pro Tyr Val Ala Val Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln 
    370                 375                 380                 

Val Asn Asn Leu Leu Cys Phe Pro Gly Ile Phe Arg Gly Ala Leu Asn 
385                 390                 395                 400 

Cys Arg Ala Arg Gln Ile Asn Glu Ala Met Lys Leu Ala Ala Ala Arg 
                405                 410                 415     

Ala Ile Ala Ser Val Val Ser Asp Glu Glu Leu His Ala Glu Tyr Ile 
            420                 425                 430         

Ile Pro Ser Val Phe Asn 
        435             

<210>   327
<211>   438
<212>   PRT
<213>   NAD-dependent malic enzyme (NAD-ME) gb|AAA22585.1| malic enzyme (EC 1.1.1.38) Score: 558 Significance: 1e-157 Identities: 281/438 Positives: 335/438 Gaps: 0/438

<400>   327
Ala Ala Met Asn Ile Thr Ile Arg Leu Gln Phe Glu Lys Asp Ile Val 
                5                   10                  15      

Ser Phe Ser Asp Ile Ala Ala Ala Ile Gly Lys Ala Gly Gly Asp Ile 
            20                  25                  30          

Val Gly Ile Asp Val Ile Ser Ser Ser Lys Val His Thr Val Arg Asp 
        35                  40                  45              

Ile Thr Val Ser Ala Leu Asp Thr Lys Gln Cys Asp Leu Ile Ile Glu 
    50                  55                  60                  

Ala Leu Lys Lys Ile Arg Gly Val Lys Ile Val Asn Val Ser Asp Arg 
65                  70                  75                  80  

Thr Phe Leu Met His Ile Gly Gly Lys Ile Glu Thr Asn Ser Lys Ile 
                85                  90                  95      

Pro Val Lys Thr Arg Asp Asp Leu Ser Arg Val Tyr Thr Pro Gly Val 
            100                 105                 110         

Ala Arg Val Cys Thr Ala Ile Ala Glu Asp Pro Arg Lys Ala Tyr Ser 
        115                 120                 125             

Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val Ser Asp Gly Thr Ala 
    130                 135                 140                 

Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala Ala Met Pro Val Met 
145                 150                 155                 160 

Glu Gly Lys Ala Met Leu Phe Lys Glu Phe Ala Gly Val Asp Ala Phe 
                165                 170                 175     

Pro Ile Cys Leu Asp Thr Lys Asp Thr Glu Glu Ile Ile Gln Ile Val 
            180                 185                 190         

Lys Ala Ile Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser 
        195                 200                 205             

Ala Pro Arg Cys Phe Glu Ile Glu Lys Arg Leu Lys Glu Glu Leu Asp 
    210                 215                 220                 

Ile Pro Val Phe His Asp Asp Gln His Gly Thr Ala Val Val Leu Leu 
225                 230                 235                 240 

Ala Gly Leu Leu Asn Ala Leu Lys Ile Val Asp Lys Lys Leu Glu Asp 
                245                 250                 255     

Ile Lys Val Val Leu Thr Gly Ile Gly Ala Ala Gly Ile Ala Cys Thr 
            260                 265                 270         

Lys Ile Leu Leu Ala Ala Gly Val Arg Asn Ile Ile Gly Val Asp Arg 
        275                 280                 285             

His Gly Ala Ile His Arg Asp Glu Thr Tyr Glu Asn Pro Tyr Trp Gln 
    290                 295                 300                 

Glu Tyr Ala Gln Leu Thr Asn Pro Asp Asn Leu Lys Gly Ser Leu Ser 
305                 310                 315                 320 

Asp Val Ile Ala Gly Ala Asp Val Phe Ile Gly Val Ser Ala Pro Gly 
                325                 330                 335     

Ile Leu Lys Val Glu Asp Val Lys Lys Met Ala Arg Asp Pro Ile Val 
            340                 345                 350         

Phe Ala Met Ala Asn Pro Ile Pro Glu Ile Asp Pro Glu Leu Ala Glu 
        355                 360                 365             

Pro Tyr Val Arg Val Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln 
    370                 375                 380                 

Ile Asn Asn Val Leu Cys Phe Pro Gly Ile Phe Arg Gly Ala Leu Asp 
385                 390                 395                 400 

Cys Arg Ala Arg Glu Ile Asn Glu Glu Met Lys Leu Ala Ala Ala Lys 
                405                 410                 415     

Ala Ile Ala Ser Val Val Thr Glu Asp Glu Leu Asn Glu Thr Tyr Ile 
            420                 425                 430         

Ile Pro Ser Val Phe Asn 
        435             

<210>   328
<211>   438
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   328
Ala Ala Met Asn Ile Thr Ile Arg Leu Gln Phe Glu Lys Asp Ile Val 
                5                   10                  15      

Ser Phe Ser Asp Ile Ala Ala Ala Ile Gly Lys Ala Gly Gly Asp Ile 
            20                  25                  30          

Val Gly Ile Asp Val Ile Ser Ser Ser Lys Val His Thr Val Arg Asp 
        35                  40                  45              

Ile Thr Val Ser Ala Leu Asp Thr Lys Gln Cys Asp Leu Ile Ile Glu 
    50                  55                  60                  

Ala Leu Lys Lys Ile Gln Gly Val Lys Ile Ile Asn Val Ser Asp Arg 
65                  70                  75                  80  

Thr Phe Leu Met His Ile Gly Gly Lys Ile Glu Thr Asn Ser Lys Ile 
                85                  90                  95      

Pro Val Lys Thr Arg Asp Asp Leu Ser Arg Val Tyr Thr Pro Gly Val 
            100                 105                 110         

Ala Arg Val Cys Thr Ala Ile Ala Glu Asp Pro Arg Lys Ala Tyr Ser 
        115                 120                 125             

Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val Ser Asp Gly Thr Ala 
    130                 135                 140                 

Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala Ala Met Pro Val Met 
145                 150                 155                 160 

Glu Gly Lys Ala Met Leu Phe Lys Glu Phe Ala Gly Val Asp Ala Phe 
                165                 170                 175     

Pro Ile Cys Leu Asn Thr Lys Asp Thr Glu Glu Ile Ile Gln Ile Val 
            180                 185                 190         

Lys Ala Ile Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser 
        195                 200                 205             

Ala Pro Arg Cys Phe Glu Ile Glu Lys Arg Leu Lys Glu Glu Leu Asp 
    210                 215                 220                 

Ile Pro Val Phe His Asp Asp Gln His Gly Thr Ala Val Val Leu Leu 
225                 230                 235                 240 

Ala Gly Leu Leu Asn Ala Leu Lys Ile Val Asp Lys Lys Leu Glu Asp 
                245                 250                 255     

Ile Lys Val Val Leu Thr Gly Ile Gly Ala Ala Gly Ile Ala Cys Thr 
            260                 265                 270         

Lys Ile Leu Leu Ala Ala Gly Val Arg Asn Ile Ile Gly Val Asp Arg 
        275                 280                 285             

His Gly Ala Ile His Arg Asp Glu Thr Tyr Glu Asn Pro Tyr Trp Gln 
    290                 295                 300                 

Glu Tyr Ala Gln Ile Thr Asn Pro Asp Asn Leu Lys Gly Ser Leu Ser 
305                 310                 315                 320 

Asp Val Ile Ala Gly Ala Asp Val Phe Ile Gly Val Ser Ala Pro Gly 
                325                 330                 335     

Ile Leu Lys Val Glu Asp Val Lys Lys Met Ala Arg Asp Pro Ile Val 
            340                 345                 350         

Phe Ala Met Ala Asn Pro Ile Pro Glu Ile Asp Pro Glu Leu Ala Glu 
        355                 360                 365             

Pro Tyr Val Arg Val Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln 
    370                 375                 380                 

Ile Asn Asn Val Leu Cys Phe Pro Gly Ile Phe Arg Gly Ala Leu Asp 
385                 390                 395                 400 

Cys Arg Ala Arg Glu Ile Asn Glu Glu Met Lys Leu Ala Ala Ala Lys 
                405                 410                 415     

Ala Ile Ala Ser Val Val Thr Glu Asp Glu Leu Asn Glu Thr Tyr Ile 
            420                 425                 430         

Ile Pro Ser Val Phe Asn 
        435             

<210>   329
<211>   435
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   329
Ser Met Thr Leu Arg Val Glu Phe Pro His Arg Ala Gly Ala Leu Gly 
                5                   10                  15      

Arg Ile Leu Thr Thr Ile Gly Asp Ala Gly Gly Met Val Gly Ala Ile 
            20                  25                  30          

Asp Ile Val Arg Met Gly Gln Glu Arg Ser Ile Arg Asp Ile Thr Val 
        35                  40                  45              

Asn Ala Arg Asp Ser Glu His Gly Gln Arg Ile Val Arg Ala Val Gly 
    50                  55                  60                  

Ala Leu Pro Glu Val Arg Val Val Asn Val Ser Asp Arg Thr Phe Leu 
65                  70                  75                  80  

Leu His Leu Gly Gly Lys Ile Glu Val His Ser Lys Ile Pro Val Arg 
                85                  90                  95      

Thr Arg Asp Asp Leu Ser Met Ala Tyr Thr Pro Gly Val Ala Arg Val 
            100                 105                 110         

Cys Arg Ala Ile Ala Gln Glu Pro Glu Arg Ala Phe Asn Leu Thr Ile 
        115                 120                 125             

Lys Arg Asn Ser Val Ala Val Val Thr Asp Gly Thr Ala Val Leu Gly 
    130                 135                 140                 

Leu Gly Asp Ile Gly Pro Tyr Ala Ala Met Pro Val Met Glu Gly Lys 
145                 150                 155                 160 

Ala Met Leu Phe Lys Glu Phe Ala Gly Val Asp Ala Phe Pro Val Cys 
                165                 170                 175     

Leu Asp Thr Lys Asp Pro Glu Glu Ile Val Arg Thr Val Lys Tyr Val 
            180                 185                 190         

Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ala Pro Arg 
        195                 200                 205             

Cys Phe Glu Ile Glu Glu Arg Leu Lys Gln Glu Leu Asp Ile Pro Val 
    210                 215                 220                 

Phe His Asp Asp Gln His Gly Thr Ala Val Val Val Leu Ala Ala Leu 
225                 230                 235                 240 

Ile Asn Ala Leu Arg Ile Val Gly Lys Arg Met Glu Glu Leu Lys Val 
                245                 250                 255     

Val Val Cys Gly Val Gly Ala Ala Gly Val Ala Cys Ala Lys Ile Leu 
            260                 265                 270         

Leu Ala Ala Gly Val Lys Asn Ile Val Gly Cys Asp Arg Tyr Gly Val 
        275                 280                 285             

Val Tyr Arg Gly Arg Gly Asp Ala Asp Thr Ser Arg Gly Trp Phe Ala 
    290                 295                 300                 

Glu Asn Thr Asn Pro Glu Asn Ile Arg Gly Thr Leu Ala Asp Ala Ile 
305                 310                 315                 320 

Arg Gly Ala Asp Val Phe Ile Gly Val Ser Ala Pro Asp Val Leu Thr 
                325                 330                 335     

Val Glu His Ile Glu Ser Met Ala Asp Glu Pro Ile Val Phe Ala Met 
            340                 345                 350         

Ala Asn Pro Asp Pro Glu Ile Arg Pro Glu Ile Ala Tyr Gly His Ala 
        355                 360                 365             

Arg Ile Ile Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn Asn 
    370                 375                 380                 

Val Leu Cys Phe Pro Gly Val Phe Arg Gly Ala Leu Asp Ile Arg Ala 
385                 390                 395                 400 

Arg Glu Ile Asn Glu Glu Met Lys Leu Ala Ala Ala Arg Ala Ile Ala 
                405                 410                 415     

Gly Val Ile Pro Glu Glu Ser Leu Ser Glu Asp Tyr Ile Ile Pro Ser 
            420                 425                 430         

Val Phe Asp 
        435 

<210>   330
<211>   377
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   330
Ile Ile Glu Ala Leu Lys Lys Ile Arg Gly Val Lys Ile Val Asn Val 
                5                   10                  15      

Ser Asp Arg Thr Phe Leu Met His Ile Gly Gly Lys Ile Glu Thr Asn 
            20                  25                  30          

Ser Lys Ile Pro Val Lys Thr Arg Asp Asp Leu Ser Arg Val Tyr Thr 
        35                  40                  45              

Pro Gly Val Ala Arg Val Cys Thr Ala Ile Ala Glu Asp Pro Arg Lys 
    50                  55                  60                  

Ala Tyr Ser Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val Ser Asp 
65                  70                  75                  80  

Gly Thr Ala Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala Ala Met 
                85                  90                  95      

Pro Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala Gly Val 
            100                 105                 110         

Asp Ala Phe Pro Val Cys Leu Asp Thr Lys Asp Thr Glu Glu Ile Ile 
        115                 120                 125             

Gln Ile Val Lys Ala Ile Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu 
    130                 135                 140                 

Asp Ile Ser Ala Pro Arg Cys Phe Glu Ile Glu Ala Arg Leu Lys Glu 
145                 150                 155                 160 

Glu Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr Ala Val 
                165                 170                 175     

Val Leu Leu Ala Gly Leu Leu Asn Ala Leu Lys Ile Val Asp Lys Lys 
            180                 185                 190         

Leu Glu Asp Ile Lys Val Val Leu Thr Gly Ile Gly Ala Ala Gly Ile 
        195                 200                 205             

Ala Cys Thr Lys Ile Leu Leu Ala Ala Gly Val Arg Asn Ile Ile Gly 
    210                 215                 220                 

Val Asp Arg Tyr Gly Ala Ile His Arg Asp Glu Thr Tyr Glu Asn Pro 
225                 230                 235                 240 

Tyr Trp Gln Glu Tyr Ala Gln Ile Thr Asn Pro Tyr Asn Leu Lys Gly 
                245                 250                 255     

Ser Leu Ser Asp Val Ile Val Gly Ala Asp Val Phe Ile Gly Val Ser 
            260                 265                 270         

Ala Pro Gly Ile Leu Lys Val Glu Asp Val Lys Lys Met Ala Arg Asp 
        275                 280                 285             

Pro Ile Val Phe Ala Met Ala Asn Pro Val Pro Glu Ile Asp Pro Glu 
    290                 295                 300                 

Leu Ala Glu Pro Tyr Val Arg Val Met Ala Thr Gly Arg Ser Asp Tyr 
305                 310                 315                 320 

Pro Asn Gln Ile Asn Asn Val Leu Cys Phe Pro Gly Ile Phe Arg Gly 
                325                 330                 335     

Ala Leu Asp Cys Arg Ala Lys Glu Ile Asn Glu Glu Met Lys Leu Ala 
            340                 345                 350         

Ala Ala Lys Ala Ile Ala Ser Val Val Thr Glu Asp Glu Leu Asn Glu 
        355                 360                 365             

Thr Tyr Ile Ile Pro Ser Val Phe Asn 
    370                 375         

<210>   331
<211>   474
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   331
Met Glu Phe Gln Arg Ser Gly Ile Ser Leu Ile Tyr Arg Leu Glu Ile 
                5                   10                  15      

Ala Asn Lys Gly Asn Thr Phe Ala Lys Val Ala Ser Leu Val Gly Asn 
            20                  25                  30          

Ala Gly Gly Asp Ile Ala Ala Val Asp Val Ile Arg Val Thr Gln Asp 
        35                  40                  45              

Val Val Val Arg Asp Val Thr Ile Asn Val Ala Asn Arg Glu His Gly 
    50                  55                  60                  

Arg Gln Ile Ala Glu Leu Leu Asp Ala Glu Pro Gly Ile His Val Val 
65                  70                  75                  80  

Ala Val Ser Asp Arg Thr Phe Leu Val His Leu Gly Gly Lys Leu Glu 
                85                  90                  95      

Val Val Pro Lys Ile Gln Val Lys Asn Arg Glu Asp Leu Ser Arg Val 
            100                 105                 110         

Tyr Thr Pro His Val Ala Arg Val Cys Glu Ala Ile His Glu Asp Pro 
        115                 120                 125             

Ser Lys Ala Phe Gln Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val 
    130                 135                 140                 

Ser Asp Gly Thr Ala Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala 
145                 150                 155                 160 

Ala Met Pro Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala 
                165                 170                 175     

Gly Val Asp Ala Phe Pro Ile Cys Leu Asp Thr Lys Asp Pro Asp Glu 
            180                 185                 190         

Ile Val Glu Thr Val Lys Arg Ile Ala Pro Ala Phe Gly Gly Ile Asn 
        195                 200                 205             

Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe Tyr Ile Glu Glu Arg Leu 
    210                 215                 220                 

Lys Gln Glu Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr 
225                 230                 235                 240 

Ala Val Val Met Leu Ala Gly Leu Met Asn Ala Ala Lys Leu Val Gly 
                245                 250                 255     

Lys Lys Leu Gln Asp Leu Lys Val Val Ile Val Gly Ile Gly Ala Ala 
            260                 265                 270         

Gly Val Ala Cys Thr Lys Met Leu Leu Ser Ala Gly Val Lys Asn Ile 
        275                 280                 285             

Ile Gly Val Thr Leu Glu Gly Ile Leu His Arg Gly Lys Gln Tyr Asp 
    290                 295                 300                 

Asn Glu Ile Trp Asn Trp Tyr Lys Glu His Thr Asn Pro Asp Asn Ile 
305                 310                 315                 320 

Thr Gly Thr Leu Glu Asp Ala Ile Val Gly Ala Asp Val Phe Ile Gly 
                325                 330                 335     

Val Ser Gly Pro Gly Val Leu Thr Val Asp His Ile Lys Lys Met Ala 
            340                 345                 350         

Pro Asp Pro Ile Val Phe Ala Met Ala Asn Pro Thr Pro Glu Ile Glu 
        355                 360                 365             

Pro Glu Leu Ala Ala Pro His Val Arg Val Leu Ala Thr Gly Arg Ser 
    370                 375                 380                 

Asp Tyr Pro Asn Gln Ile Asn Asn Leu Leu Cys Phe Pro Gly Met Phe 
385                 390                 395                 400 

Lys Gly Ala Leu Ala Ala Arg Ala Ser Thr Ile Asn Glu Glu Met Lys 
                405                 410                 415     

Leu Ala Ala Ala Gln Ala Ile Ala Ser Ile Ile Arg Glu Asn Glu Leu 
            420                 425                 430         

Arg Glu Asp Tyr Ile Ile Pro Ser Val Phe Asn Gln Ala Val Val Gln 
        435                 440                 445             

Arg Val Ala Asp Ala Val Ala Asp Ala Ala Arg Arg Thr Gly Val Ala 
    450                 455                 460                 

Arg Arg Glu Val Met Pro Lys Asp Asn Tyr 
465                 470                 

<210>   332
<211>   474
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   332
Met Glu Phe Gln Arg Ser Gly Ile Ser Leu Ile Tyr Arg Leu Glu Ile 
                5                   10                  15      

Ala Asn Lys Gly Asn Thr Phe Ala Lys Val Ala Ser Leu Val Gly Asn 
            20                  25                  30          

Ala Gly Gly Asp Ile Ala Ala Val Asp Val Ile Arg Val Thr Gln Asp 
        35                  40                  45              

Val Val Val Arg Asp Val Thr Ile Asn Val Ala Asn Arg Glu His Gly 
    50                  55                  60                  

Arg Gln Ile Ala Glu Leu Leu Asp Ala Glu Pro Gly Ile His Val Val 
65                  70                  75                  80  

Ala Val Ser Asp Arg Thr Phe Leu Val His Leu Gly Gly Lys Leu Glu 
                85                  90                  95      

Val Val Pro Lys Ile Gln Val Lys Asn Arg Glu Asp Leu Ser Arg Val 
            100                 105                 110         

Tyr Thr Pro His Val Ala Arg Val Cys Glu Ala Ile His Glu Asp Pro 
        115                 120                 125             

Ser Lys Ala Phe Gln Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val 
    130                 135                 140                 

Ser Asp Gly Thr Ala Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala 
145                 150                 155                 160 

Ala Met Pro Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala 
                165                 170                 175     

Gly Val Asp Ala Phe Pro Ile Cys Leu Asp Thr Lys Asp Pro Asp Glu 
            180                 185                 190         

Ile Val Glu Thr Val Lys Arg Ile Ala Pro Ala Phe Gly Gly Ile Asn 
        195                 200                 205             

Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe Tyr Ile Glu Glu Arg Leu 
    210                 215                 220                 

Lys Gln Glu Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr 
225                 230                 235                 240 

Ala Val Val Met Leu Ala Gly Leu Met Asn Ala Ala Lys Leu Val Gly 
                245                 250                 255     

Lys Lys Leu Gln Asp Leu Lys Val Val Ile Ile Gly Ile Gly Ala Ala 
            260                 265                 270         

Gly Val Ala Cys Thr Lys Met Leu Leu Ser Ala Gly Val Lys Asn Ile 
        275                 280                 285             

Ile Gly Val Thr Leu Glu Gly Ile Leu His Arg Gly Lys Gln Tyr Asp 
    290                 295                 300                 

Asn Glu Ile Trp Asn Trp Tyr Lys Glu His Thr Asn Pro Asp Asn Ile 
305                 310                 315                 320 

Thr Gly Thr Leu Asp Asp Ala Ile Val Gly Ala Asp Val Phe Ile Gly 
                325                 330                 335     

Val Ser Gly Pro Gly Val Leu Thr Val Asp His Ile Lys Lys Met Ala 
            340                 345                 350         

Pro Asp Pro Ile Val Phe Ala Met Ala Asn Pro Thr Pro Glu Ile Glu 
        355                 360                 365             

Pro Glu Leu Ala Ala Pro His Val Arg Val Leu Ala Thr Gly Arg Ser 
    370                 375                 380                 

Asp Tyr Pro Asn Gln Ile Asn Asn Leu Leu Cys Phe Pro Gly Met Phe 
385                 390                 395                 400 

Lys Gly Ala Leu Ala Ala Arg Ala Ser Thr Ile Asn Glu Glu Met Lys 
                405                 410                 415     

Leu Ala Ala Ala Gln Ala Ile Ala Ser Ile Ile Arg Glu Asn Glu Leu 
            420                 425                 430         

Arg Glu Asp Tyr Ile Ile Pro Ser Val Phe Asn Gln Ala Val Val Gln 
        435                 440                 445             

Arg Val Ala Asp Ala Val Ala Asp Ala Ala Arg Arg Thr Gly Val Ala 
    450                 455                 460                 

Arg Arg Glu Val Met Pro Lys Asp Asn Tyr 
465                 470                 

<210>   333
<211>   474
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   333
Met Glu Phe Gln Arg Ser Gly Ile Ser Leu Ile Tyr Arg Leu Glu Ile 
                5                   10                  15      

Ala Asn Lys Gly Asn Thr Phe Ala Arg Val Ala Ser Leu Val Gly Asn 
            20                  25                  30          

Ala Gly Gly Asp Ile Ala Ala Val Asp Val Ile Arg Val Thr Gln Asp 
        35                  40                  45              

Val Val Val Arg Asp Val Thr Ile Asn Val Ala Asn Arg Glu His Gly 
    50                  55                  60                  

Arg Gln Ile Ala Glu Leu Leu Asp Ala Glu Pro Gly Ile His Val Val 
65                  70                  75                  80  

Ala Val Ser Asp Arg Thr Phe Leu Val His Leu Gly Gly Lys Leu Glu 
                85                  90                  95      

Val Val Pro Lys Ile Gln Val Lys Asn Arg Glu Asp Leu Ser Arg Val 
            100                 105                 110         

Tyr Thr Pro His Val Ala Arg Val Cys Glu Ala Ile His Glu Asp Pro 
        115                 120                 125             

Ser Lys Ala Phe Gln Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val 
    130                 135                 140                 

Ser Asp Gly Thr Ala Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala 
145                 150                 155                 160 

Ala Met Pro Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala 
                165                 170                 175     

Gly Val Asp Ala Phe Pro Ile Cys Leu Asp Thr Lys Asp Pro Asp Glu 
            180                 185                 190         

Ile Val Glu Thr Val Lys Arg Ile Ala Pro Ala Phe Gly Gly Ile Asn 
        195                 200                 205             

Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe Tyr Ile Glu Glu Arg Leu 
    210                 215                 220                 

Lys Gln Glu Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr 
225                 230                 235                 240 

Ala Val Val Met Leu Ala Gly Leu Met Asn Ala Ala Lys Leu Val Gly 
                245                 250                 255     

Lys Lys Leu Gln Asp Leu Lys Val Val Ile Val Gly Ile Gly Ala Ala 
            260                 265                 270         

Gly Val Ala Cys Thr Lys Met Leu Leu Ser Ala Gly Val Lys Asn Ile 
        275                 280                 285             

Ile Gly Val Thr Leu Glu Gly Ile Leu His Arg Gly Lys Gln Tyr Asp 
    290                 295                 300                 

Asn Glu Ile Trp Asn Trp Tyr Lys Glu His Thr Asn Pro Asp Asn Ile 
305                 310                 315                 320 

Thr Gly Thr Leu Asp Asp Ala Ile Val Gly Ala Asp Val Phe Ile Gly 
                325                 330                 335     

Val Ser Gly Pro Gly Val Leu Thr Val Asp His Ile Lys Lys Met Ala 
            340                 345                 350         

Pro Asp Pro Ile Val Phe Ala Met Ala Asn Pro Thr Pro Glu Ile Glu 
        355                 360                 365             

Pro Glu Leu Ala Ala Pro His Val Arg Val Leu Ala Thr Gly Arg Ser 
    370                 375                 380                 

Asp Tyr Pro Asn Gln Ile Asn Asn Leu Leu Cys Phe Pro Gly Met Phe 
385                 390                 395                 400 

Lys Gly Ala Leu Ala Ala Arg Ala Ser Thr Ile Asn Glu Glu Met Lys 
                405                 410                 415     

Leu Ala Ala Ala Gln Ala Ile Ala Ser Ile Ile Arg Glu Asn Glu Leu 
            420                 425                 430         

Arg Glu Asp Tyr Ile Ile Pro Ser Val Phe Asn Gln Ala Val Val Gln 
        435                 440                 445             

Arg Val Ala Asp Ala Val Ala Asp Ala Ala Arg Arg Thr Gly Val Ala 
    450                 455                 460                 

Arg Arg Glu Val Met Pro Lys Asp Asn Tyr 
465                 470                 

<210>   334
<211>   474
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   334
Met Glu Phe Gln Arg Ser Gly Ile Ser Leu Ile Tyr Arg Leu Glu Ile 
                5                   10                  15      

Ala Asn Lys Gly Asn Thr Phe Ala Lys Val Ala Ser Ile Val Gly Asn 
            20                  25                  30          

Ala Gly Gly Asp Ile Ala Ala Val Asp Val Ile Arg Val Thr Gln Asp 
        35                  40                  45              

Val Val Val Arg Asp Val Thr Ile Asn Val Ala Asn Arg Glu His Gly 
    50                  55                  60                  

Arg Gln Ile Ala Glu Leu Leu Asp Ala Glu Pro Gly Ile His Val Val 
65                  70                  75                  80  

Ala Val Ser Asp Arg Thr Phe Leu Val His Leu Gly Gly Lys Leu Glu 
                85                  90                  95      

Val Val Pro Lys Ile Gln Val Lys Asn Arg Glu Asp Leu Ser Arg Val 
            100                 105                 110         

Tyr Thr Pro His Val Ala Arg Val Cys Glu Ala Ile His Glu Asp Pro 
        115                 120                 125             

Ser Lys Ala Phe Gln Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val 
    130                 135                 140                 

Ser Asp Gly Thr Ala Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala 
145                 150                 155                 160 

Ala Met Pro Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala 
                165                 170                 175     

Gly Val Asp Ala Phe Pro Ile Cys Leu Asp Thr Lys Asp Pro Asp Glu 
            180                 185                 190         

Ile Val Glu Thr Val Lys Arg Ile Ala Pro Ala Phe Gly Gly Ile Asn 
        195                 200                 205             

Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe Tyr Ile Glu Glu Arg Leu 
    210                 215                 220                 

Lys Gln Glu Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr 
225                 230                 235                 240 

Ala Val Val Met Leu Ala Gly Leu Met Asn Ala Ala Lys Leu Val Gly 
                245                 250                 255     

Lys Lys Leu Gln Asp Leu Lys Val Val Ile Val Gly Ile Gly Ala Ala 
            260                 265                 270         

Gly Val Ala Cys Thr Lys Met Leu Leu Ser Ala Gly Val Lys Asn Ile 
        275                 280                 285             

Ile Gly Val Thr Leu Glu Gly Ile Leu His Arg Gly Lys Gln Tyr Asp 
    290                 295                 300                 

Asn Glu Ile Trp Asn Trp Tyr Lys Glu His Thr Asn Pro Asp Asn Ile 
305                 310                 315                 320 

Thr Gly Thr Leu Asp Asp Ala Ile Val Gly Ala Asp Val Phe Ile Gly 
                325                 330                 335     

Val Ser Gly Pro Gly Val Leu Thr Val Asp His Ile Lys Lys Met Ala 
            340                 345                 350         

Pro Asp Pro Ile Val Phe Ala Met Ala Asn Pro Thr Pro Glu Ile Glu 
        355                 360                 365             

Pro Glu Leu Ala Ala Pro His Val Arg Val Leu Ala Thr Gly Arg Ser 
    370                 375                 380                 

Asp Tyr Pro Asn Gln Ile Asn Asn Leu Leu Cys Phe Pro Gly Met Phe 
385                 390                 395                 400 

Lys Gly Ala Leu Ala Ala Arg Ala Ser Thr Ile Asn Glu Glu Met Lys 
                405                 410                 415     

Leu Ala Ala Ala Gln Ala Ile Ala Ser Ile Ile Arg Glu Asn Glu Leu 
            420                 425                 430         

Arg Glu Asp Tyr Ile Ile Pro Ser Val Phe Asn Gln Ala Val Val Gln 
        435                 440                 445             

Arg Val Ala Asp Ala Val Ala Asp Ala Ala Arg Arg Thr Gly Val Ala 
    450                 455                 460                 

Arg Arg Glu Val Met Pro Lys Asp Asn Tyr 
465                 470                 

<210>   335
<211>   474
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   335
Met Glu Phe Gln Arg Ser Gly Ile Ser Leu Ile Tyr Arg Leu Glu Ile 
                5                   10                  15      

Ala Asn Lys Gly Asn Thr Phe Ala Lys Val Ala Ser Leu Val Gly Asn 
            20                  25                  30          

Ala Gly Gly Asp Ile Ala Ala Val Asp Val Ile Arg Val Thr Gln Asp 
        35                  40                  45              

Val Val Val Arg Asp Val Thr Ile Asn Val Ala Asn Arg Glu His Gly 
    50                  55                  60                  

Arg Gln Ile Ala Glu Leu Leu Asp Ala Glu Pro Gly Ile His Val Val 
65                  70                  75                  80  

Ala Val Ser Asp Arg Thr Phe Leu Val His Leu Gly Gly Lys Leu Glu 
                85                  90                  95      

Val Ile Pro Lys Ile Gln Val Lys Asn Arg Glu Asp Leu Ser Arg Val 
            100                 105                 110         

Tyr Thr Pro His Val Ala Arg Val Cys Glu Ala Ile His Glu Asp Pro 
        115                 120                 125             

Ser Lys Ala Phe Gln Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val 
    130                 135                 140                 

Ser Asp Gly Thr Ala Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala 
145                 150                 155                 160 

Ala Met Pro Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala 
                165                 170                 175     

Gly Val Asp Ala Phe Pro Ile Cys Leu Asp Thr Lys Asp Pro Asp Glu 
            180                 185                 190         

Ile Val Glu Thr Val Lys Arg Ile Ala Pro Ala Phe Gly Gly Ile Asn 
        195                 200                 205             

Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe Tyr Ile Glu Glu Arg Leu 
    210                 215                 220                 

Lys Gln Glu Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr 
225                 230                 235                 240 

Ala Val Val Met Leu Ala Gly Leu Met Asn Ala Ala Lys Leu Val Gly 
                245                 250                 255     

Lys Lys Leu Gln Asp Leu Lys Val Val Ile Val Gly Ile Gly Ala Ala 
            260                 265                 270         

Gly Val Ala Cys Thr Lys Met Leu Leu Ser Ala Gly Val Lys Asn Ile 
        275                 280                 285             

Ile Gly Val Thr Leu Glu Gly Ile Leu His Arg Gly Lys Gln Tyr Asp 
    290                 295                 300                 

Asn Glu Ile Trp Asn Trp Tyr Lys Glu His Thr Asn Pro Asp Asn Ile 
305                 310                 315                 320 

Thr Gly Thr Leu Asp Asp Ala Ile Val Gly Ala Asp Val Phe Ile Gly 
                325                 330                 335     

Val Ser Gly Pro Gly Val Leu Thr Val Asp His Ile Lys Lys Met Ala 
            340                 345                 350         

Pro Asp Pro Ile Val Phe Ala Met Ala Asn Pro Thr Pro Glu Ile Glu 
        355                 360                 365             

Pro Glu Leu Ala Ala Pro His Val Arg Val Leu Ala Thr Gly Arg Ser 
    370                 375                 380                 

Asp Tyr Pro Asn Gln Ile Asn Asn Leu Leu Cys Phe Pro Gly Met Phe 
385                 390                 395                 400 

Lys Gly Ala Leu Ala Ala Arg Ala Ser Thr Ile Asn Glu Glu Met Lys 
                405                 410                 415     

Leu Ala Ala Ala Gln Ala Ile Ala Ser Ile Ile Arg Glu Asn Glu Leu 
            420                 425                 430         

Arg Glu Asp Tyr Ile Ile Pro Ser Val Phe Asn Gln Ala Val Val Gln 
        435                 440                 445             

Arg Val Ala Asp Ala Val Ala Asp Ala Ala Arg Arg Thr Gly Val Ala 
    450                 455                 460                 

Arg Arg Glu Val Met Pro Lys Asp Asn Tyr 
465                 470                 

<210>   336
<211>   1425
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   336
atggagtttc agcggagtgg catcagtctg atttatcgac tggagatcgc caataagggc       60

aacacgtttg cgaaggtggc gagcctggtc gggaacgctg gaggcgatat tgctgcggtc      120

gacgtgatcc gcgtgacgca ggacgtggtg gtgcgagacg tgaccatcaa cgtggcgaat      180

cgcgagcatg gccgccagat cgccgagttg ctcgacgcgg agccggggat ccacgtggtg      240

gcggtgtccg accggacctt cctcgttcac ttgggcggca agctcgaagt tgtgccgaag      300

atccaggtga agaaccgcga ggatctttcg cgcgtgtaca cgccgcacgt ggcgcgcgtg      360

tgcgaggcga ttcacgagga cccgtccaag gcgttccaac tgaccatcaa gcgcaacacg      420

gtggccgtgg tctcggacgg cacggcggtg ttgggcctcg gggacatcgg cccgtacgcg      480

gcgatgccgg tcatggaagg caaggccatg ctgttcaaac agttcgcagg cgtggacgcg      540

ttccccatct gcctcgacac gaaggatccg gacgagatcg tcgagacggt gaagcgcatc      600

gcgccggcgt ttggcggcat caatctggag gatatctcgt ctccgagatg cttctatatc      660

gaggagcggc tgaagcagga gctcgacatc cctgtcttcc acgacgacca acacgggacg      720

gcggtcgtca tgctggccgg cctgatgaac gcggcgaagc tcgtcgggaa gaagcttcag      780

gacctcaagg tcgtgatcgt cggcatcggc gctgcgggcg tggcctgcac gaaaatgctc      840

ttgtccgccg gtgtgaaaaa catcatcggc gtcacgctgg agggcatcct gcaccgcggc      900

aagcagtacg acaacgagat ctggaattgg tacaaggagc acacgaatcc ggacaacatc      960

acgggcacgc tggaagacgc catcgtgggc gcggacgtgt tcatcggcgt gtcgggacct     1020

ggcgtgctga cggtcgatca catcaagaag atggcgcccg atccgattgt cttcgcgatg     1080

gccaacccga cgccggagat cgagccggaa ctggcggctc cccatgtgcg cgtgctcgcc     1140

accggtcgat ccgactaccc gaaccagatc aacaacctcc tctgtttccc gggcatgttc     1200

aagggggcgc tggcggcgcg cgcgtcgacc atcaacgagg agatgaagct cgcggctgcg     1260

caggccattg cttccatcat ccgtgagaac gagttgcgcg aggactacat tattccgtct     1320

gtctttaacc aagcggttgt tcagcgagtc gcggacgcgg tcgccgatgc cgcccgccga     1380

acgggcgtgg cgcgccgcga agtgatgccg aaggacaact attga                     1425


<210>   337
<211>   1425
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   337
atggagtttc agcggagtgg catcagtctg atttatcgac tggagatcgc caataagggc       60

aacacgtttg cgaaggtggc gagcctggtc gggaacgctg gaggcgatat tgctgcggtc      120

gacgtgatcc gcgtgacgca ggacgtggtg gtgcgagacg tgaccatcaa cgtggcgaat      180

cgcgagcatg gccgccagat cgccgagttg ctcgacgcgg agccggggat ccacgtggtg      240

gcggtgtccg accggacctt cctcgttcac ttgggcggca agctcgaagt tgtgccgaag      300

atccaggtga agaaccgcga ggatctttcg cgcgtgtaca cgccgcacgt ggcgcgcgtg      360

tgcgaggcga ttcacgagga cccgtccaag gcgttccaac tgaccatcaa gcgcaacacg      420

gtggccgtgg tctcggacgg cacggcggtg ttgggcctcg gggacatcgg cccgtacgcg      480

gcgatgccgg tcatggaagg caaggccatg ctgttcaaac agttcgcagg cgtggacgcg      540

ttccccatct gcctcgacac gaaggatccg gacgagatcg tcgagacggt gaagcgcatc      600

gcgccggcgt ttggcggcat caatctggag gatatctcgt ctccgagatg cttctatatc      660

gaggagcggc tgaagcagga gctcgacatc cctgtcttcc acgacgacca acacgggacg      720

gcggtcgtca tgctggccgg cctgatgaac gcggcgaagc tcgtcgggaa gaagcttcag      780

gacctcaagg tcgtgatcat tggcatcggc gctgcgggcg tggcctgcac gaaaatgctc      840

ttgtccgccg gtgtgaaaaa catcatcggc gtcacgctgg agggcatcct gcaccgcggc      900

aagcagtacg acaacgagat ctggaattgg tacaaggagc acacgaatcc ggacaacatc      960

acgggcacgc tggacgacgc catcgtgggc gcggacgtgt tcatcggcgt gtcgggacct     1020

ggcgtgctga cggtcgatca catcaagaag atggcgcccg atccgattgt cttcgcgatg     1080

gccaacccga cgccggagat cgagccggaa ctggcggctc cccatgtgcg cgtgctcgcc     1140

accggtcgat ccgactaccc gaaccagatc aacaacctcc tctgtttccc gggcatgttc     1200

aagggggcgc tggcggcgcg cgcgtcgacc atcaacgagg agatgaagct cgcggctgcg     1260

caggccattg cttccatcat ccgtgagaac gagttgcgcg aggactacat tattccgtct     1320

gtctttaacc aagcggttgt tcagcgagtc gcggacgcgg tcgccgatgc cgcccgccga     1380

acgggcgtgg cgcgccgcga agtgatgccg aaggacaact attga                     1425


<210>   338
<211>   1425
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   338
atggagtttc agcggagtgg catcagtctg atttatcgac tggagatcgc caataagggc       60

aacacgtttg cgcgtgtggc gagcctggtc gggaacgctg gaggcgatat tgctgcggtc      120

gacgtgatcc gcgtgacgca ggacgtggtg gtgcgagacg tgaccatcaa cgtggcgaat      180

cgcgagcatg gccgccagat cgccgagttg ctcgacgcgg agccggggat ccacgtggtg      240

gcggtgtccg accggacctt cctcgttcac ttgggcggca agctcgaagt tgtgccgaag      300

atccaggtga agaaccgcga ggatctttcg cgcgtgtaca cgccgcacgt ggcgcgcgtg      360

tgcgaggcga ttcacgagga cccgtccaag gcgttccaac tgaccatcaa gcgcaacacg      420

gtggccgtgg tctcggacgg cacggcggtg ttgggcctcg gggacatcgg cccgtacgcg      480

gcgatgccgg tcatggaagg caaggccatg ctgttcaaac agttcgcagg cgtggacgcg      540

ttccccatct gcctcgacac gaaggatccg gacgagatcg tcgagacggt gaagcgcatc      600

gcgccggcgt ttggcggcat caatctggag gatatctcgt ctccgagatg cttctatatc      660

gaggagcggc tgaagcagga gctcgacatc cctgtcttcc acgacgacca acacgggacg      720

gcggtcgtca tgctggccgg cctgatgaac gcggcgaagc tcgtcgggaa gaagcttcag      780

gacctcaagg tcgtgatcgt cggcatcggc gctgcgggcg tggcctgcac gaaaatgctc      840

ttgtccgccg gtgtgaaaaa catcatcggc gtcacgctgg agggcatcct gcaccgcggc      900

aagcagtacg acaacgagat ctggaattgg tacaaggagc acacgaatcc ggacaacatc      960

acgggcacgc tggacgacgc catcgtgggc gcggacgtgt tcatcggcgt gtcgggacct     1020

ggcgtgctga cggtcgatca catcaagaag atggcgcccg atccgattgt cttcgcgatg     1080

gccaacccga cgccggagat cgagccggaa ctggcggctc cccatgtgcg cgtgctcgcc     1140

accggtcgat ccgactaccc gaaccagatc aacaacctcc tctgtttccc gggcatgttc     1200

aagggggcgc tggcggcgcg cgcgtcgacc atcaacgagg agatgaagct cgcggctgcg     1260

caggccattg cttccatcat ccgtgagaac gagttgcgcg aggactacat tattccgtct     1320

gtctttaacc aagcggttgt tcagcgagtc gcggacgcgg tcgccgatgc cgcccgccga     1380

acgggcgtgg cgcgccgcga agtgatgccg aaggacaact attga                     1425


<210>   339
<211>   1425
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   339
atggagtttc agcggagtgg catcagtctg atttatcgac tggagatcgc caataagggc       60

aacacgtttg cgaaggtggc gagcattgtc gggaacgctg gaggcgatat tgctgcggtc      120

gacgtgatcc gcgtgacgca ggacgtggtg gtgcgagacg tgaccatcaa cgtggcgaat      180

cgcgagcatg gccgccagat cgccgagttg ctcgacgcgg agccggggat ccacgtggtg      240

gcggtgtccg accggacctt cctcgttcac ttgggcggca agctcgaagt tgtgccgaag      300

atccaggtga agaaccgcga ggatctttcg cgcgtgtaca cgccgcacgt ggcgcgcgtg      360

tgcgaggcga ttcacgagga cccgtccaag gcgttccaac tgaccatcaa gcgcaacacg      420

gtggccgtgg tctcggacgg cacggcggtg ttgggcctcg gggacatcgg cccgtacgcg      480

gcgatgccgg tcatggaagg caaggccatg ctgttcaaac agttcgcagg cgtggacgcg      540

ttccccatct gcctcgacac gaaggatccg gacgagatcg tcgagacggt gaagcgcatc      600

gcgccggcgt ttggcggcat caatctggag gatatctcgt ctccgagatg cttctatatc      660

gaggagcggc tgaagcagga gctcgacatc cctgtcttcc acgacgacca acacgggacg      720

gcggtcgtca tgctggccgg cctgatgaac gcggcgaagc tcgtcgggaa gaagcttcag      780

gacctcaagg tcgtgatcgt cggcatcggc gctgcgggcg tggcctgcac gaaaatgctc      840

ttgtccgccg gtgtgaaaaa catcatcggc gtcacgctgg agggcatcct gcaccgcggc      900

aagcagtacg acaacgagat ctggaattgg tacaaggagc acacgaatcc ggacaacatc      960

acgggcacgc tggacgacgc catcgtgggc gcggacgtgt tcatcggcgt gtcgggacct     1020

ggcgtgctga cggtcgatca catcaagaag atggcgcccg atccgattgt cttcgcgatg     1080

gccaacccga cgccggagat cgagccggaa ctggcggctc cccatgtgcg cgtgctcgcc     1140

accggtcgat ccgactaccc gaaccagatc aacaacctcc tctgtttccc gggcatgttc     1200

aagggggcgc tggcggcgcg cgcgtcgacc atcaacgagg agatgaagct cgcggctgcg     1260

caggccattg cttccatcat ccgtgagaac gagttgcgcg aggactacat tattccgtct     1320

gtctttaacc aagcggttgt tcagcgagtc gcggacgcgg tcgccgatgc cgcccgccga     1380

acgggcgtgg cgcgccgcga agtgatgccg aaggacaact attga                     1425


<210>   340
<211>   1425
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   340
atggagtttc agcggagtgg catcagtctg atttatcgac tggagatcgc caataagggc       60

aacacgtttg cgaaggtggc gagcctggtc gggaacgctg gaggcgatat tgctgcggtc      120

gacgtgatcc gcgtgacgca ggacgtggtg gtgcgagacg tgaccatcaa cgtggcgaat      180

cgcgagcatg gccgccagat cgccgagttg ctcgacgcgg agccggggat ccacgtggtg      240

gcggtgtccg accggacctt cctcgttcac ttgggcggca agctcgaagt tattccgaag      300

atccaggtga agaaccgcga ggatctttcg cgcgtgtaca cgccgcacgt ggcgcgcgtg      360

tgcgaggcga ttcacgagga cccgtccaag gcgttccaac tgaccatcaa gcgcaacacg      420

gtggccgtgg tctcggacgg cacggcggtg ttgggcctcg gggacatcgg cccgtacgcg      480

gcgatgccgg tcatggaagg caaggccatg ctgttcaaac agttcgcagg cgtggacgcg      540

ttccccatct gcctcgacac gaaggatccg gacgagatcg tcgagacggt gaagcgcatc      600

gcgccggcgt ttggcggcat caatctggag gatatctcgt ctccgagatg cttctatatc      660

gaggagcggc tgaagcagga gctcgacatc cctgtcttcc acgacgacca acacgggacg      720

gcggtcgtca tgctggccgg cctgatgaac gcggcgaagc tcgtcgggaa gaagcttcag      780

gacctcaagg tcgtgatcgt cggcatcggc gctgcgggcg tggcctgcac gaaaatgctc      840

ttgtccgccg gtgtgaaaaa catcatcggc gtcacgctgg agggcatcct gcaccgcggc      900

aagcagtacg acaacgagat ctggaattgg tacaaggagc acacgaatcc ggacaacatc      960

acgggcacgc tggacgacgc catcgtgggc gcggacgtgt tcatcggcgt gtcgggacct     1020

ggcgtgctga cggtcgatca catcaagaag atggcgcccg atccgattgt cttcgcgatg     1080

gccaacccga cgccggagat cgagccggaa ctggcggctc cccatgtgcg cgtgctcgcc     1140

accggtcgat ccgactaccc gaaccagatc aacaacctcc tctgtttccc gggcatgttc     1200

aagggggcgc tggcggcgcg cgcgtcgacc atcaacgagg agatgaagct cgcggctgcg     1260

caggccattg cttccatcat ccgtgagaac gagttgcgcg aggactacat tattccgtct     1320

gtctttaacc aagcggttgt tcagcgagtc gcggacgcgg tcgccgatgc cgcccgccga     1380

acgggcgtgg cgcgccgcga agtgatgccg aaggacaact attga                     1425


<210>   341
<211>   906
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   341
Met Ala Asn Asp Ala Pro Leu His Arg Asp Ile Arg Val Leu Gly Asp 
                5                   10                  15      

Leu Leu Gly Glu Val Leu Val Glu Gln Cys Gly Arg Arg Val Phe Asp 
            20                  25                  30          

His Val Glu Ser Ile Arg Leu Ala Ala Lys Ala Phe Arg Ala Asp Pro 
        35                  40                  45              

Ser Pro Glu Thr Arg Ala Ala Leu Gln Ala Ala Val Ser Ala Val Glu 
    50                  55                  60                  

Pro Glu His Arg Asn Asp Val Ile His Ala Phe Ser Val Tyr Phe Gln 
65                  70                  75                  80  

Leu Val Asn Leu Ala Glu Gln Asn His Arg Leu Arg Arg His Arg Asp 
                85                  90                  95      

Tyr Asp Arg Ser Gln Gln Val Leu Arg Gly Ser Phe Arg Glu Thr Met 
            100                 105                 110         

Arg Thr Leu Ala Asp Arg Gly Met Thr Ala Asp Asp Ile Glu Ser Leu 
        115                 120                 125             

Leu Arg Glu Val Gly Ile Glu Leu Val Leu Thr Ala His Pro Thr Glu 
    130                 135                 140                 

Ala Leu Arg Arg Thr Val Leu Asp Lys His Thr Lys Ile Ala Ala Phe 
145                 150                 155                 160 

Leu Glu Asp Met Asp Asp Pro Arg Lys Thr Pro Arg Glu Leu Asp Val 
                165                 170                 175     

Leu Arg Glu Arg Ile Arg Thr Glu Ile Val Ala Leu Trp Gln Thr Arg 
            180                 185                 190         

Ser Val Arg Lys Gln Arg Ile Thr Val Leu Asp Glu Val Arg Asn Gly 
        195                 200                 205             

Leu Tyr Phe Leu Asp Gln Ile Leu Phe Asp Val Leu Pro Arg Val His 
    210                 215                 220                 

Gln Lys Leu Glu Gln Ala Val Glu Glu Gln Phe Gly Arg Gln Leu Leu 
225                 230                 235                 240 

Glu Leu Pro Pro Leu Ile Arg Phe Gly Ser Trp Met Gly Gly Asp Arg 
                245                 250                 255     

Asp Gly Asn Pro Asn Val Thr Ser Asp Ile Thr Trp Gln Thr Leu Val 
            260                 265                 270         

Leu His Cys Asp Leu Ala Leu Asn Lys Tyr Glu Gln Lys Leu Arg Glu 
        275                 280                 285             

Leu Gly Arg Asp Leu Ser Val Ser Val Asp Arg Ala Gly Ala Asp Glu 
    290                 295                 300                 

Asp Leu Leu Ala Ser Leu Gly Gly Glu Asn Asp Glu Pro Tyr Arg Ala 
305                 310                 315                 320 

Leu Ile Asn Arg Met Leu Glu Arg Leu Ala Asn Thr Arg Arg Arg Leu 
                325                 330                 335     

His Gly Glu Arg Val Asp Gly Pro Asp Tyr Ala Ser Pro Glu Ala Met 
            340                 345                 350         

Met Glu Asp Val Glu Arg Met Ala Arg Ser Leu Ala His His Arg Gly 
        355                 360                 365             

Gln Arg Met Val Asp Ala Trp Leu Arg Pro Phe Leu Leu Gln Leu Arg 
    370                 375                 380                 

Ile Phe Gly Phe His Met Val Thr Leu Asp Ile Arg Gln His Ser Gly 
385                 390                 395                 400 

Val His Glu Gln Ala Val Ala Glu Leu Leu Gln Thr Ala Gly Leu Val 
                405                 410                 415     

Asp Asp Tyr Thr Ser Leu Gly Glu Glu Glu Arg Val Arg Val Leu Ser 
            420                 425                 430         

Glu Cys Leu Ala Ser Pro Arg Pro Ile Arg Asn Pro Tyr His Val Tyr 
        435                 440                 445             

Ser Asp Val Thr Thr Glu Ala Leu Ala Val Leu Asp Cys Val Arg Arg 
    450                 455                 460                 

Gly His Glu Thr Phe Gly Pro Arg Cys Val Gln Asp Tyr Leu Ile Ser 
465                 470                 475                 480 

Met Thr Gln Gly Ala Ser Asp Leu Leu Glu Val Leu Leu Leu Ala Lys 
                485                 490                 495     

Glu Ser Gly Leu Phe Gly Trp Pro Asp Gly Pro Met Ala Pro Pro Lys 
            500                 505                 510         

Ser Asp Leu Asn Val Val Pro Leu Phe Glu Thr Ile Glu Asp Leu Glu 
        515                 520                 525             

Ser Ala Ala Gly Ile Met Arg Ser Leu Phe Glu Asn Pro Val Tyr Arg 
    530                 535                 540                 

Arg His Leu Glu Met Arg Gly Trp Gln Gln Glu Ile Met Leu Gly Tyr 
545                 550                 555                 560 

Ser Asp Ser Asn Lys Asp Gly Gly Tyr Leu Thr Ala Asn Trp Ser Leu 
                565                 570                 575     

Tyr Met Ala Gln Lys His Leu Ile Arg Leu Ala Glu Ala Tyr Gly Val 
            580                 585                 590         

Arg Ile Lys Phe Phe His Gly Arg Gly Gly Ala Leu Gly Arg Gly Gly 
        595                 600                 605             

Gly Pro Val Glu Gln Ser Ile Leu Ala Gln Pro Thr Glu Ala Leu Arg 
    610                 615                 620                 

Gly His Val Lys Ile Thr Glu Gln Gly Glu Val Ile Ser Gln Arg Tyr 
625                 630                 635                 640 

Gly His Pro Gly Ile Ala Glu Arg Ser Leu Glu Ser Ser Ala Ala Ala 
                645                 650                 655     

Val Leu Val Gly Ala Thr Arg Glu Asp Ser Glu Glu Trp Ala Glu Arg 
            660                 665                 670         

His Pro Arg Trp Phe Arg Leu Leu Asp Arg Ala Ser Glu Ile Ser Phe 
        675                 680                 685             

Arg Ala Tyr Arg Lys Leu Val Phe Glu His Pro Ala Phe Leu Glu Tyr 
    690                 695                 700                 

Phe His Arg Ala Thr Pro Ile Asp Glu Ile Gly Lys Met Asn Ile Gly 
705                 710                 715                 720 

Ser Arg Pro Ser Arg Arg Ser Gln Ser Ala Arg Ile Glu Asp Leu Arg 
                725                 730                 735     

Ala Ile Pro Trp Val Phe Ser Trp Thr Gln Ser Arg His Leu Leu Pro 
            740                 745                 750         

Ala Trp Tyr Gly Phe Gly Ser Ala Ile Glu Ala Ile Met Arg Glu Asp 
        755                 760                 765             

Pro Arg Ala Leu Glu Asp Leu Arg Arg Met Tyr Glu Val Trp Pro Phe 
    770                 775                 780                 

Phe Arg Thr Leu Val Asp Asn Leu Gln Met Ala Leu Ala Lys Ala Asp 
785                 790                 795                 800 

Met Leu Val Ala Lys Glu Tyr Ala Gln Leu Ala Gly Glu Ala Gly Glu 
                805                 810                 815     

Ala Val Phe Pro Leu Ile Glu Glu Glu Tyr Ala Arg Thr Glu Arg Ala 
            820                 825                 830         

Val Leu Asp Ile Thr Gly Tyr Arg Gln Leu Leu Asp Asn Arg Pro Val 
        835                 840                 845             

Ile Arg Glu Ser Ile Ser Leu Arg Asn Pro Tyr Val Asp Pro Leu Ser 
    850                 855                 860                 

Phe Phe Gln Val Arg Leu Leu Ala Asp Leu Arg Thr Asp Asn Leu Ser 
865                 870                 875                 880 

Pro Glu Glu Arg Glu Ala Glu Leu Ala Asp Ala Leu Gln Thr Ile Asn 
                885                 890                 895     

Gly Ile Ala Ala Gly Leu Arg Asn Thr Gly 
            900                 905     

<210>   342
<211>   2721
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   342
ttggcgaacg acgcaccctt gcaccgggac atacgcgtcc tcggggattt gttgggagaa       60

gtgctggtcg agcagtgcgg ccggcgcgtc ttcgatcacg tcgaatccat tcgcctcgct      120

gccaaggcct ttcgcgcgga cccgtcgccc gaaacgcgcg cggcgctgca ggcggccgtg      180

tccgccgtgg agcccgagca ccggaacgac gtgattcacg cgttttcggt ctactttcag      240

ttggtcaacc tcgcggagca aaaccacagg cttcgccgcc accgagatta cgatcgctcg      300

caacaggtgc tgcgcgggtc gtttcgcgaa accatgcgca ccctggccga tcgcggcatg      360

accgccgacg acattgagtc cctgcttcgg gaggtcggga tcgagctcgt gctcaccgcg      420

catcccaccg aggcgctgcg ccgcaccgtg ctcgacaaac acacgaagat cgcggctttc      480

ctcgaggaca tggacgatcc gcgcaagacg ccgagagagc tcgacgtgct gcgcgagcga      540

attcgcaccg agatcgtcgc gctgtggcaa acgagatcgg tgcgcaagca gcgcatcacc      600

gtgctggatg aggtccgaaa cgggctgtac tttctggacc agatcctgtt cgacgtcctt      660

cctcgcgtgc atcaaaagct cgaacaggcg gtcgaggaac agtttggtcg tcagcttctc      720

gaactgcccc cgcttattcg cttcggctcg tggatggggg gcgatcgcga cggcaatccg      780

aacgtcacgt ccgacatcac ctggcagacg ctcgtcctcc actgcgatct cgccctcaac      840

aaatatgagc aaaagttgcg agaactcggg cgcgatctga gcgtgtccgt ggaccgggcg      900

ggcgcggacg aggatctcct ggcttccctg ggaggcgaaa acgacgagcc gtaccgggcg      960

ctcatcaacc ggatgctgga gcggctcgcc aacacgcggc gccggctgca cggggagcgg     1020

gtggacggtc ccgattacgc gtcacccgaa gcgatgatgg aggacgtcga acggatggcg     1080

agatcgctcg cgcatcaccg gggccagcgc atggtggatg cgtggttgcg cccgttcctg     1140

ctgcagcttc gcatcttcgg cttccacatg gtgacgctcg acatccgtca gcactccggc     1200

gttcatgagc aggcggtggc ggagctcttg cagacggcgg gcctcgtgga cgactacacg     1260

tcgcttggcg aggaagagcg cgtgcgcgtc ctgtccgaat gccttgcgtc gccgcgcccc     1320

attcgcaatc cgtatcacgt gtactccgat gtcaccacgg aggcgctcgc ggtcctcgac     1380

tgcgtgcggc gagggcacga gaccttcggg cctcgctgcg tgcaggacta cctcatttcc     1440

atgacgcaag gcgcgagcga cctgcttgag gtgttgctct tggcgaagga gtccggcttg     1500

ttcggctggc cggacgggcc gatggcgccg cccaagagcg acttgaacgt cgttccgctg     1560

tttgagacca tcgaggacct ggagtccgcg gcggggatca tgcggtcgct gtttgaaaac     1620

cccgtgtatc ggcgtcacct ggagatgcgc ggctggcagc aggagatcat gctcgggtat     1680

tccgacagca acaaggacgg cggctatctc accgccaact ggtcgctgta catggctcaa     1740

aagcacctga ttcgcctggc ggaagcgtac ggcgtgcgca tcaagttctt tcacggccgg     1800

ggcggcgcgc tggggcgagg gggcggtccc gtggagcaga gcattctcgc ccagcccacg     1860

gaggcgctcc gagggcacgt gaagatcacg gagcagggcg aggtcatctc gcagcggtat     1920

ggacacccgg gcatcgccga acgctcgctt gagtcctcgg cggcggctgt gctggtgggc     1980

gccacgcgag aggacagcga ggagtgggca gagcgccatc cgaggtggtt tcggcttttg     2040

gaccgagcgt cggaaatcag cttccgcgcc taccggaagc tggtcttcga gcatcccgcg     2100

ttcctcgagt atttccatcg ggcgacgccc attgacgaga tcggcaagat gaacattggg     2160

tcgaggcctt cgcggcgctc gcagtcggcg cgaatcgagg acctgcgggc catcccctgg     2220

gtgttctcgt ggacgcagag ccgccacctg ctgcccgcct ggtacggctt cggcagtgcg     2280

atagaggcca tcatgcggga ggaccctcgc gcgcttgaag accttcgccg catgtacgag     2340

gtgtggccgt tcttccggac gctggtcgac aatcttcaga tggcgctcgc caaggcggat     2400

atgctcgtgg cgaaggaata cgcgcagttg gcgggggagg cgggagaggc cgtctttccg     2460

ctgattgagg aggagtacgc gcgcacggag cgcgccgtgc tcgacatcac gggctaccgg     2520

cagcttctcg acaacaggcc ggtcatacgg gagtccatct cgcttcgcaa cccgtatgtc     2580

gatccgctgt cgttcttcca ggtgcgcctg ttggccgatc tgcgcacgga caacctgtcg     2640

cccgaagagc gcgaggcgga gctggccgac gcgctgcaga ccattaacgg catcgccgcg     2700

ggcctgcgca ataccggctg a                                               2721


<210>   343
<211>   886
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   343
Gly Glu Ala Leu Leu Lys Thr Ile Gln Asn Ile Arg Ser Leu Ala Gln 
                5                   10                  15      

Lys Ala Arg Glu Thr Gly Asp Glu Ala Phe Tyr Leu Gln Leu Lys Lys 
            20                  25                  30          

Glu Ile Thr Asp Leu Asn Pro Pro Glu Arg Gln Glu Val Ile Arg Ala 
        35                  40                  45              

Phe Ser Thr Tyr Leu Gln Leu Phe Asn Ile Thr Glu Gln Asn Phe Arg 
    50                  55                  60                  

Ile Lys Arg Arg Arg Glu Tyr Gln Ser Glu Asp Thr Asp Gln Val Gln 
65                  70                  75                  80  

Pro Arg Ser Leu Glu Asp Gly Ile Glu Thr Leu Arg Lys Glu Lys Val 
                85                  90                  95      

Pro Ala Glu Met Val Ala Glu Leu Leu Asn Ser Leu Ser Leu Glu Leu 
            100                 105                 110         

Ile Ile Thr Ala His Pro Thr Glu Ala Thr Arg Arg Thr Ile Leu Gln 
        115                 120                 125             

Ile His Lys Arg Ile Ala Asp Leu Leu Lys Ala Leu Glu Tyr Ala Asn 
    130                 135                 140                 

Thr Arg Tyr Glu Lys Lys Val Ile Glu Glu Thr Ile Leu Asn Glu Ile 
145                 150                 155                 160 

Thr Ile Leu Trp Gln Ser Ser Glu Ile Arg Glu Lys Lys Pro Ser Val 
                165                 170                 175     

Leu Asp Glu Val Lys Asn Gly Leu Tyr Tyr Phe Asp Asn Val Leu Phe 
            180                 185                 190         

Asp Val Leu Pro Arg Ile His Glu Asp Leu Glu Asp Tyr Leu His Glu 
        195                 200                 205             

Ser Tyr Gly Gln Arg Phe Lys Val Pro Ser Tyr Leu His Phe Gly Ser 
    210                 215                 220                 

Trp Ile Gly Gly Asp Arg Asp Gly Asn Pro Asn Val Thr Ala Asp Ile 
225                 230                 235                 240 

Thr Trp Lys Thr Leu Glu Met Gln Arg Glu Leu Val Leu Glu Lys Tyr 
                245                 250                 255     

Lys Lys Ser Leu Thr Thr Leu Arg Glu Leu Leu Ser His Ser Ser Lys 
            260                 265                 270         

Lys Ile Ser Ala Ser His Ala Leu Leu Ala Ser Val Glu Ser Glu Glu 
        275                 280                 285             

Asn Thr Met Pro Ala Ala Lys Leu Trp Pro Thr Lys Asp Glu Ile Tyr 
    290                 295                 300                 

Arg Arg Lys Leu Thr Ile Met Ile His Lys Leu Glu Cys Val Gly Lys 
305                 310                 315                 320 

Asn Asn Gly Gly Tyr Gln Ser Ala Lys Glu Leu Leu Ala Asp Leu Tyr 
                325                 330                 335     

Met Ile Arg Asp Ser Val Asn Gln His His Pro Ala Gly His Pro Ile 
            340                 345                 350         

Lys Leu Leu Arg Lys Val Ile Arg Gln Val Glu Leu Phe Gly Phe His 
        355                 360                 365             

Leu Ala Ser Leu Asp Ile Arg Asn His Ser Gly Glu His Glu Ser Ala 
    370                 375                 380                 

Leu Ala Glu Val Leu Tyr Asn Val Asn Ile Ala Lys Asp Tyr Lys Asn 
385                 390                 395                 400 

Leu Ser Glu Asp Glu Lys Val Ala Val Leu Leu Lys Ala Leu Asn Asp 
                405                 410                 415     

Pro Arg Pro Met Ile Ser Ile Tyr Asp Thr Phe Thr Pro Glu Thr Gln 
            420                 425                 430         

Glu Val Ile Asn Thr Phe Arg Met Ile Lys Arg Ala His Gln Thr Phe 
        435                 440                 445             

Gly Glu Arg Ser Ile Gln Val Tyr Leu Ile Ser Met Ala His Ser Val 
    450                 455                 460                 

Ser Asp Val Leu Glu Val Leu Val Leu Ala Lys Glu Ala Gly Leu Tyr 
465                 470                 475                 480 

Arg Val Tyr Pro Ser Gly Asp Ile Leu Ser Glu Ile His Ile Ala Pro 
                485                 490                 495     

Leu Leu Glu Thr Ile Ala Asp Leu Arg Asn Gly Ala Lys Met Leu Glu 
            500                 505                 510         

Thr Leu Phe Gln Met Pro Ile Tyr Arg Asn His Leu Lys Val Arg Gly 
        515                 520                 525             

Asn Leu Gln Glu Val Met Leu Gly Tyr Ser Asp Gly Ser Lys Asp Gly 
    530                 535                 540                 

Gly Thr Met Thr Ala Asn Trp Gln Leu Tyr Lys Ala Gln Lys Glu Ile 
545                 550                 555                 560 

His Glu Met Gly Ala Lys Tyr Gly Ile Lys Leu Lys Phe Phe His Gly 
                565                 570                 575     

Arg Gly Gly Ser Leu Gly Arg Gly Gly Gly Pro Leu Tyr Ser Ser Leu 
            580                 585                 590         

Leu Ser Gln Pro Pro Val Thr Leu Gly Asp Gly Val Lys Ile Thr Glu 
        595                 600                 605             

Gln Gly Glu Val Leu Ser Ser Arg Tyr Leu Leu Arg Asp Ile Ala Tyr 
    610                 615                 620                 

Arg Ser Leu Glu Gln Ala Thr Ser Thr Met Met Cys Ala Ile Thr Glu 
625                 630                 635                 640 

Gln Lys Gln Asn Glu Lys Asn Gly Lys Thr Pro Asn Glu Glu Ala Val 
                645                 650                 655     

Arg Ala Met Asp Lys Ile Ser Glu Tyr Ala Leu Glu Lys Tyr Gln Glu 
            660                 665                 670         

Leu Val Phe Arg Asp Pro Asp Phe Leu Ser Tyr Phe Lys Gln Ala Thr 
        675                 680                 685             

Pro Leu Asn Glu Ile Gly Glu Leu Asn Ile Gly Ser Arg Pro Met Ser 
    690                 695                 700                 

Arg Lys Gly Ser Ala Arg Phe Glu Asp Leu Arg Ala Ile Pro Trp Val 
705                 710                 715                 720 

Phe Ser Trp Thr Gln Ser Arg Gln Leu Leu Pro Ala Trp Tyr Ala Ala 
                725                 730                 735     

Gly Thr Gly Leu Ser Lys Tyr Val Glu Glu Thr Gly Asn Phe Lys Leu 
            740                 745                 750         

Leu Gln Glu Met Tyr Ala Ser Trp Pro Phe Phe His Ala Thr Ile Asn 
        755                 760                 765             

Asn Leu Gln Met Ala Leu Ile Lys Ala Glu Leu Ser Thr Ala Glu Glu 
    770                 775                 780                 

Tyr Thr Arg Leu Val Lys Asp Pro Glu Val Ala Gly Arg Ile Phe Gly 
785                 790                 795                 800 

Leu Ile Lys Ala Glu Tyr Glu Leu Thr Lys Glu Met Val Leu Lys Ile 
                805                 810                 815     

Ala Asp Gln Lys Glu Leu Leu Asp Tyr Thr Pro Asn Ile Lys Glu Ser 
            820                 825                 830         

Val Arg Leu Arg Asn Pro Tyr Val Asp Pro Leu Asn Leu Phe Gln Val 
        835                 840                 845             

Tyr Leu Ile Ser Gln Leu Arg Glu Arg Glu Asn Lys Asp Glu Lys Ala 
    850                 855                 860                 

Arg His Leu Leu Met Glu Val Leu Leu Thr Ile Asn Gly Ile Ala Ala 
865                 870                 875                 880 

Gly Leu Arg Asn Thr Gly 
                885     

<210>   344
<211>   890
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   344
Gly Glu Ala Leu Phe Asn Glu Val Glu Glu Ile Arg Glu Met Thr Lys 
                5                   10                  15      

Ala Leu Arg Lys Ser Tyr Asp Glu Ala Asn Glu Lys Glu Leu Lys Lys 
            20                  25                  30          

Arg Ile Glu Asn Leu Lys Ser Pro Met Arg Gln Gln Val Ile Arg Ala 
        35                  40                  45              

Phe Ala Ile Tyr Phe His Leu Val Asn Ile Ala Glu Gln His His Arg 
    50                  55                  60                  

Ile Arg Arg Ser Arg Gln Tyr Arg Met Lys Arg Gly Glu Asn Ile Gln 
65                  70                  75                  80  

Pro Ser Ser Ile Glu Ala Ala Ile Val Asn Ile Gln Lys Glu Lys Tyr 
                85                  90                  95      

Pro Glu Thr Val Ile Gln Gln Val Leu Asp Asp Ser Ser Ile Glu Leu 
            100                 105                 110         

Ile Met Thr Ala His Pro Thr Glu Ala Thr Lys Arg Thr Ile Leu Glu 
        115                 120                 125             

Ile Gln Lys Arg Ile Ser Tyr Ile Leu Glu Gln Phe Asp Asn Pro Ala 
    130                 135                 140                 

Leu Thr Glu Lys Glu Arg Glu Asp His Glu Glu Ser Leu Ile Asn Glu 
145                 150                 155                 160 

Val Thr Ala Leu Trp His Thr Asp Glu Leu Arg Phe Lys Lys Pro Thr 
                165                 170                 175     

Val Ile Asp Glu Val Lys Asn Gly Leu Tyr Tyr Phe Asp Thr Thr Leu 
            180                 185                 190         

Phe Asp Val Leu Pro Ala Val His Gln Glu Ile Glu Glu Gln Leu Glu 
        195                 200                 205             

Arg Tyr Tyr Pro Asp Gln Asp Phe Lys Val Pro Asn Phe Ile His Phe 
    210                 215                 220                 

Gly Ser Trp Ile Gly Gly Asp Arg Asp Gly Asn Pro Phe Val Thr Pro 
225                 230                 235                 240 

Glu Val Thr Trp Glu Thr Leu Asn Leu Gln Arg Asp Leu Thr Leu Arg 
                245                 250                 255     

Lys Tyr Glu Glu Ser Ile Thr Glu Leu Met Arg Arg Phe Ser Gln Ser 
            260                 265                 270         

Thr Thr Arg Val Asp Ile Asp Pro Glu Phe Ile Glu Thr Met Glu Gln 
        275                 280                 285             

Tyr Glu Lys Lys Tyr Met Lys Lys Ser Glu Thr Trp Pro Val Thr Thr 
    290                 295                 300                 

Glu Ile Tyr Arg Arg Met Leu Gly Ala Ile Arg Lys Arg Ile Arg Gln 
305                 310                 315                 320 

Val Gly Lys Thr Asn Thr Gly Tyr Asp Val Ala Glu Glu Leu Leu Ala 
                325                 330                 335     

Asp Leu Arg Tyr Val Arg Glu Asn Ala Leu Lys His Gln Leu Pro Asn 
            340                 345                 350         

Gln Lys Leu Lys Gln Leu Asn Lys Met Ile Arg Gln Val Glu Leu Phe 
        355                 360                 365             

Gly Phe His Leu Ala Thr Leu Asp Val Arg Asn His Ser Gly Glu His 
    370                 375                 380                 

Glu Thr Ala Ile Ala Glu Ile Leu Lys Val Val Gly Ile Thr Glu Asp 
385                 390                 395                 400 

Tyr Lys Ser Leu Asp Glu Glu Glu Lys Met Thr Ile Leu Glu Asn Ala 
                405                 410                 415     

Leu Lys Asp Pro Arg Pro Leu Met Leu Leu Asn Glu Asp Tyr Ser Glu 
            420                 425                 430         

Glu Thr Arg Glu Ile Phe Lys Val Phe Gln Met Ile Lys Asp Ala His 
        435                 440                 445             

Glu Glu Phe Gly Gln Arg Ser Ile Glu Val Tyr Leu Val Ser Met Thr 
    450                 455                 460                 

Gln Ser Ala Ser Asp Leu Leu Glu Val Leu Val Leu Ala Lys Glu Ala 
465                 470                 475                 480 

Gly Ile Tyr Arg Leu His Ala Asp Gly Ser Val Asp Ser Asn Leu His 
                485                 490                 495     

Val Ala Pro Leu Leu Glu Thr Val Asp Asp Leu Met Ala Gly Pro Ala 
            500                 505                 510         

Ile Met Lys Arg Leu Phe Glu Met Asp Ile Tyr Arg Thr His Leu Gly 
        515                 520                 525             

Glu Arg Gly Asp His Gln Glu Ile Met Leu Gly Tyr Ser Asp Gly Ser 
    530                 535                 540                 

Lys Asp Gly Gly Thr Leu Thr Ala Asn Trp Lys Leu Phe Glu Ala Gln 
545                 550                 555                 560 

Ala Lys Ile His Asn Met Ala Lys Asp Tyr Asn Val Arg Leu Lys Phe 
                565                 570                 575     

Phe His Gly Arg Gly Gly Ser Leu Gly Arg Gly Gly Gly Pro Leu Asn 
            580                 585                 590         

Arg Ser Ile Val Ser Gln Pro Ala Glu Thr Leu Gly Asp Gly Val Lys 
        595                 600                 605             

Ile Thr Glu Gln Gly Glu Val Leu Ser Ser Arg Tyr Leu Leu Gly Asp 
    610                 615                 620                 

Ile Ala Phe Arg Asn Leu Glu Gln Ala Ala Ser Ala Leu Leu Glu Ala 
625                 630                 635                 640 

Ser Ala Asn Val Tyr Ala Ser Pro Gly Asp Ser Cys His Ile Arg Arg 
                645                 650                 655     

Pro Gln Trp Glu Glu Ala Met Glu Glu Ile Ser Lys Ala Ser Leu Ser 
            660                 665                 670         

Lys Tyr Gln Ser Leu Val Phe Lys Asp Pro Asp Phe Leu Thr Tyr Phe 
        675                 680                 685             

Lys Glu Thr Thr Pro Leu Asn Glu Leu Lys Glu Leu Asn Ile Gly Ser 
    690                 695                 700                 

Arg Pro Met Ser Arg Lys Gly Ser Glu Arg Phe Glu Asp Leu Arg Ala 
705                 710                 715                 720 

Ile Pro Trp Val Phe Ala Trp Thr Gln Cys Arg Gln Met Leu Pro Ala 
                725                 730                 735     

Trp Tyr Ala Ser Gly Thr Gly Leu Ala Ala Tyr Gly Lys Ala Ser Glu 
            740                 745                 750         

Glu Asn Leu Glu Leu Leu Gln Asp Met Tyr Gln Asn Trp Pro Phe Phe 
        755                 760                 765             

His Ser Thr Ile Asn Asn Leu Gln Met Ala Leu Met Lys Ala Asp Leu 
    770                 775                 780                 

Phe Ala Ala Lys Glu Tyr Val Lys Leu Val Lys Asp Gln Glu Met Gly 
785                 790                 795                 800 

Gln Arg Ile Tyr Gly Glu Ile Glu Lys Glu Phe Asn Leu Thr Lys Glu 
                805                 810                 815     

Met Leu Leu Lys Ile Ser Gly Ser Glu Gln Leu Leu Asp Phe Thr Pro 
            820                 825                 830         

Asn Ile Arg Asp Ser Val His Leu Arg Asn Pro Tyr Val Asp Pro Leu 
        835                 840                 845             

Asn Phe Leu Gln Val Asp Leu Ile Glu Lys Met Arg Glu Ser Ser Ser 
    850                 855                 860                 

Glu Glu Arg Thr Glu Glu Leu Leu Thr Glu Val Leu Leu Thr Ile Ser 
865                 870                 875                 880 

Gly Val Ala Ala Gly Leu Leu Asn Thr Gly 
                885                 890 

<210>   345
<211>   912
<212>   PRT
<213>   Dechloromonas aromatica RCB

<400>   345
Ser Lys Asp Glu Pro Leu Arg Thr Asp Ile Arg Leu Leu Gly Arg Ile 
                5                   10                  15      

Leu Gly Asp Thr Val Arg Glu Gln Glu Gly Glu Ser Val Phe Asp Ile 
            20                  25                  30          

Val Glu Arg Val Arg Gln Thr Ala Val Arg Phe Ala Arg Asp Gly Asp 
        35                  40                  45              

Pro Ala Ala Arg Asp Glu Leu Ala Ala Leu Leu Asp Pro Leu Pro Gly 
    50                  55                  60                  

Asp Thr Thr Gln Ala Val Val Arg Ala Phe Ser Tyr Phe Leu Gln Leu 
65                  70                  75                  80  

Ala Asn Ile Ala Glu Asp Glu His His Ile Arg Arg Arg Arg Ala His 
                85                  90                  95      

Asp Leu Ala Gly Ser Pro Pro Arg Glu Gly Ser Leu Ile Phe Ala Leu 
            100                 105                 110         

Asp Ala Leu Ser Thr Ala Ala Val Ser Pro Glu Ala Ile Ala Asp Phe 
        115                 120                 125             

Phe Ala His Ala Val Val Ala Pro Val Leu Thr Ala His Pro Thr Glu 
    130                 135                 140                 

Val Gln Arg Gln Ser Leu Ile Arg Asn His Arg Asp Leu Ala His Leu 
145                 150                 155                 160 

Leu Asp Gln Arg Glu Arg Leu Gln Met Thr Pro Glu Glu Glu Ala Glu 
                165                 170                 175     

Asn Asp Leu Ala Leu Ala Asn Ala Ile Leu Thr Leu Trp Gln Ser Arg 
            180                 185                 190         

Met Leu Arg Pro Val Arg Leu Lys Val Leu Asp Glu Val Lys Asn Gly 
        195                 200                 205             

Ile Thr Tyr Phe Lys Glu Thr Phe Phe Thr Glu Leu Pro Arg Leu Tyr 
    210                 215                 220                 

Ile Gln Ala Thr Glu Gln Leu Gln Lys Arg Tyr Pro Glu Lys Thr Trp 
225                 230                 235                 240 

Ala Leu Pro Pro Phe Phe Arg Val Gly Ser Trp Ile Gly Gly Asp Arg 
                245                 250                 255     

Asp Gly Asn Pro Phe Val Thr Ala Asp Ile Leu Arg Glu Ala Leu Arg 
            260                 265                 270         

Leu Gln Ser Ser Ala Ala Leu Asn His Tyr Leu Asn Glu Val His Glu 
        275                 280                 285             

Leu Gly Gly Glu Leu Pro Leu Ser Asp Leu Leu Val Lys Val Thr Pro 
    290                 295                 300                 

Glu Leu Leu Ala Leu Ala Glu His Ser Thr Asp His Ser Pro Gln Arg 
305                 310                 315                 320 

Ala Asp Glu Pro Tyr Arg Arg Ala Leu Ser Gly Ile Tyr Ala Arg Leu 
                325                 330                 335     

Ala Ala Thr Ala Arg Ala Leu Asp Gln Phe Glu Pro Val Arg His Glu 
            340                 345                 350         

Ile Gly His Ala Thr Pro Tyr Asp Thr Pro Asp Ala Leu Arg Ala Asp 
        355                 360                 365             

Leu Lys Leu Leu Ala Asn Ser Leu Lys Leu Asn Gly Ser Ala Lys Leu 
    370                 375                 380                 

Ala Gly Gly Arg Leu Arg Arg Leu Leu Arg Gly Val Gln Ile Phe Gly 
385                 390                 395                 400 

Phe His Leu Ala Pro Ile Asp Leu Arg Gln Asn Ser Asp Val His Ala 
                405                 410                 415     

Arg Ser Val Ala Glu Leu Leu Ala Gly Ala Gly Arg Cys Pro Asp Tyr 
            420                 425                 430         

Glu Ala Leu Ser Glu Ala Glu Arg Ile Lys Leu Leu Val Asp Glu Ile 
        435                 440                 445             

Ser Thr Pro Arg Pro Leu Tyr Ser Pro Tyr Leu Asn Tyr Ser Glu Glu 
    450                 455                 460                 

Thr Gln Gly Glu Leu Ala Ile Phe Phe Ala Ala Arg Glu Leu Arg Gln 
465                 470                 475                 480 

Lys Tyr Gly Ser Ala Ala Leu Pro Asn Cys Ile Ile Ser Lys Thr Asp 
                485                 490                 495     

Gly Val Ser Asp Leu Leu Glu Leu Ala Leu Leu Leu Lys Glu Ser Gly 
            500                 505                 510         

Leu Leu Leu Pro Gly Ala Lys Pro Gln Leu Lys Val Asn Ile Ile Pro 
        515                 520                 525             

Leu Phe Glu Thr Ile Glu Asp Leu Gln Lys Ser Ala Ala Thr Met Ala 
    530                 535                 540                 

Gly Val Phe Ala Ile Pro Ala Tyr Arg Glu Leu Ile Ala Gly Arg Gly 
545                 550                 555                 560 

Asp Glu His Glu Val Met Leu Gly Tyr Ser Asp Ser Asn Lys Asp Gly 
                565                 570                 575     

Gly Phe Leu Thr Ser Gly Trp Glu Leu Tyr Lys Ala Glu Ile Glu Leu 
            580                 585                 590         

Ala Arg Ile Phe Gly Gln His Gly Val Arg Leu Arg Leu Phe His Gly 
        595                 600                 605             

Arg Gly Gly Ser Val Gly Arg Gly Gly Gly Pro Thr Tyr His Ala Ile 
    610                 615                 620                 

Leu Ala Gln Pro Ala Gly Ala Val Ala Gly Gln Ile Arg Leu Thr Glu 
625                 630                 635                 640 

Gln Gly Glu Val Ile Ser Thr Lys Tyr Gly Asn Ala Asp Thr Gly Arg 
                645                 650                 655     

Arg Asn Leu Glu Val Leu Leu Ala Ala Thr Leu Glu Ala Ser Leu Thr 
            660                 665                 670         

Asp His Glu Asn Arg Val Glu Pro Ala Glu Gln Phe His Ala Val Met 
        675                 680                 685             

Asp Glu Leu Ser Ala Arg Ala Phe Asn Ala Tyr Arg Gly Leu Val Tyr 
    690                 695                 700                 

Glu Thr Pro Gly Phe Thr Thr Tyr Phe Arg Gln Ser Thr Val Val Ser 
705                 710                 715                 720 

Glu Ile Ala Ser Leu Asn Ile Gly Ser Arg Pro Ala Ser Arg Lys Ala 
                725                 730                 735     

Ser Glu Arg Ile Glu Asp Leu Arg Ala Ile Pro Trp Val Phe Ser Trp 
            740                 745                 750         

Ala Gln Cys Arg Leu Met Leu Pro Gly Trp Tyr Gly Phe Gly Ala Ala 
        755                 760                 765             

Val Glu Gly Tyr Leu Gln Ala Asn Pro Ala Gly Leu Ala Thr Leu Arg 
    770                 775                 780                 

Arg Met Val His Ala Trp Pro Phe Phe Lys Ser Leu Leu Ser Asn Met 
785                 790                 795                 800 

Asp Met Val Leu Ala Lys Thr Asp Leu Ala Ile Ala Ser Arg Tyr Ala 
                805                 810                 815     

Glu Leu Val Ala Asp Val Glu Leu Arg Glu His Ile Phe Ser Arg Ile 
            820                 825                 830         

Lys Ala Glu Trp Ala Leu Thr Arg Gln His Leu Leu Ala Ile Leu Glu 
        835                 840                 845             

Gln Asp Glu Phe Leu Ala Asp Asn Pro Leu Leu Ala Arg Ser Leu Gln 
    850                 855                 860                 

Leu Arg Ser Pro Tyr Met Asp Pro Leu Asn His Leu Gln Val Glu Leu 
865                 870                 875                 880 

Leu Lys Arg His Arg Ala Gly Asp Thr Asp Glu Arg Leu Ala Arg Gly 
                885                 890                 895     

Ile His Leu Thr Ile Asn Gly Ile Ala Ser Gly Leu Arg Asn Ser Gly 
            900                 905                 910         

<210>   346
<211>   901
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   346
Gln Asp Gly Val Ser Ala Phe Glu Leu Glu Glu Asp Val Arg Gln Arg 
                5                   10                  15      

Thr Lys Gln Arg Arg Ser Asp Gly Thr Leu Gln Glu Thr Gln Thr Leu 
            20                  25                  30          

Thr Glu Leu Ile Ser Gln Leu Pro Val Ala Gln Leu Met Gly Leu Ile 
        35                  40                  45              

Lys Ala Phe Thr His Tyr Phe Gly Leu Val Asn Leu Ala Glu Ser Val 
    50                  55                  60                  

Glu Arg Leu Arg Val Leu Ala Glu Arg Asp Arg Gln Asn Gly Asp Ala 
65                  70                  75                  80  

Pro Arg Ser Glu Ser Val Glu Leu Ala Leu Gln Glu Leu Arg Asp Arg 
                85                  90                  95      

Gly Ile Thr Ala Gln Gln Val Gln Asp Leu Leu Asp His Ala Glu Ile 
            100                 105                 110         

Arg Pro Val Phe Thr Ala His Pro Thr Glu Ala Lys Arg Arg Thr Thr 
        115                 120                 125             

Leu Lys Lys His His Arg Ile Ala Gly Ala Ala Arg Gln Leu Thr Ala 
    130                 135                 140                 

Asp Thr Thr Phe Gln Arg Gln Arg Glu Arg Leu Leu Glu Ser Ile Arg 
145                 150                 155                 160 

Glu Glu Val Ile Ser Leu Trp Gln Ser Asp Glu Val Arg Ile Ile Lys 
                165                 170                 175     

Pro Thr Val Ile Asp Glu Val Lys Asn Asn Leu Tyr Tyr Phe Glu Glu 
            180                 185                 190         

Ser Leu Phe Asp Met Ile Pro Gln Leu Tyr Arg Asp Thr Glu Ala Ser 
        195                 200                 205             

Leu Arg Gln Ile Tyr Pro Glu His Glu Trp Arg Val Pro Ala Phe Leu 
    210                 215                 220                 

Arg Phe Gly Ser Trp Val Gly Gly Asp Arg Asp Gly Asn Pro Phe Val 
225                 230                 235                 240 

Ile Pro Ser Val Thr Val Glu Thr Leu Lys Leu Leu Met Gly Arg Ser 
                245                 250                 255     

Leu Arg Glu His Ile His Ser Val Glu Arg Leu Ser His Arg Leu Ser 
            260                 265                 270         

Gln Ser Ser Arg Gln Val Pro Ile Ser Glu Glu Leu Ala Gln Ser Leu 
        275                 280                 285             

Ile His Asp Ala Pro Leu Phe Pro Glu Leu Ala Gln Val Leu Glu Arg 
    290                 295                 300                 

Arg Asn Pro His Glu Pro Tyr Arg Gln Lys Cys Ser Tyr Ile His Ala 
305                 310                 315                 320 

Lys Leu His Ala Thr Leu Ala Tyr Val Glu Arg Tyr Glu Pro Asp Trp 
                325                 330                 335     

Ala Arg Gly Gly His Arg Pro Ala Glu Gly Thr Trp Tyr Ala Asn Ala 
            340                 345                 350         

Asn Gln Tyr Leu Ala Asp Leu Ala Thr Met Glu Tyr Ser Leu Arg Thr 
        355                 360                 365             

Asn Gly Ala Ala Ser Val Ala Asp Gly Phe Leu Arg Asp Ile Gln Cys 
    370                 375                 380                 

Ser Ala Lys Val Phe Gly Leu His Thr Ala Thr Leu Asp Ile Arg Gln 
385                 390                 395                 400 

His Ser Ser Arg His Thr Asn Ala Leu Ser Glu Ile Phe Glu Tyr Ala 
                405                 410                 415     

Gly Ile Cys Asp Asp Tyr Ala Ser Leu Ser Gln Ala Glu Arg Thr Ala 
            420                 425                 430         

Val Leu Glu Arg Glu Leu Ala Asn Asn Arg Pro Leu Ile Pro Thr His 
        435                 440                 445             

Leu Tyr Tyr Ser Pro Glu Thr Val Glu Ile Ile Glu Thr Phe Arg Thr 
    450                 455                 460                 

Ile Arg Ala Val Leu Ser Asp Leu Asn Ala Glu Ala Ile Glu Thr Tyr 
465                 470                 475                 480 

Ile Ile Ser Met Thr Glu Gly Pro Ser Asp Ile Leu Ala Val Leu Leu 
                485                 490                 495     

Leu Ala Arg Glu Ala Gly Ile Tyr Gln Pro Gly Glu His Ser Trp Leu 
            500                 505                 510         

Asn Ile Val Pro Leu Phe Glu Thr Gly Ala Asp Leu Ile Ala Ala Pro 
        515                 520                 525             

Glu Ile Met His Thr Leu Leu Ser Ser Glu Ala Tyr Arg Gln His Leu 
    530                 535                 540                 

Val Leu Arg Asn Asp Val Gln Glu Ile Met Leu Gly Tyr Ser Asp Ser 
545                 550                 555                 560 

Asn Lys Asp Gly Gly Phe Ala Asp Ala His Trp Ala Leu Tyr Leu Ala 
                565                 570                 575     

Gln Val Ala Leu Ala Glu Thr Cys Phe Arg His Arg Val Ala Met Arg 
            580                 585                 590         

Leu Phe His Gly Arg Gly Gly Ala Val Gly Arg Gly Gly Gly Pro Ala 
        595                 600                 605             

Asn Arg Ala Ile Leu Gly Gln Pro Pro Gly Thr Val Gly Gly Arg Ile 
    610                 615                 620                 

Lys Ile Thr Glu Gln Gly Glu Val Ile Ser Asp Arg Tyr Ala Glu Pro 
625                 630                 635                 640 

Glu Thr Ala Tyr Arg His Gln Glu Gln Ile Ile Asn Ala Val Leu Arg 
                645                 650                 655     

Ser Ser Leu Gly Val Ser Ile Ala His Ile Ser Gln Glu Trp His Asp 
            660                 665                 670         

Ala Met Ser Ser Leu Ala Lys Val Ser Arg Lys Val Tyr Arg Gly Leu 
        675                 680                 685             

Val Tyr Asp His Pro His Phe Leu Glu Tyr Phe Arg Asn Ala Thr Pro 
    690                 695                 700                 

Ile Thr Glu Ile Ser Arg Leu Asn Ile Gly Ser Arg Pro Ala Ser Arg 
705                 710                 715                 720 

Lys Ala Ser Asp Arg Ile Glu Asp Leu Arg Ala Ile Pro Trp Val Phe 
                725                 730                 735     

Ser Trp Met Gln Ser Arg His Thr Leu Pro Gly Trp Tyr Gly Leu Gly 
            740                 745                 750         

Ser Ala Leu Glu His Leu Ile Gln Ala Asp Ala Asn Gly Leu Thr Thr 
        755                 760                 765             

Leu Gln Gly Met Tyr Asn Asp Trp Pro Phe Phe Arg Thr Met Leu Asp 
    770                 775                 780                 

Asn Ala Gln Met Ile Leu Ser Lys Ala Asp Met Asp Ile Ala Ala Gln 
785                 790                 795                 800 

Tyr Ala Leu Leu Val Pro Asp Gln Ala Leu Ala Asn Glu Ile Phe Gly 
                805                 810                 815     

Leu Ile Lys Ala Glu Tyr Thr Arg Thr Val Lys Trp Ile Cys Glu Val 
            820                 825                 830         

Ala Gln Ile Asn Glu Leu Leu Asp Thr Ser Pro Ile Leu Gln His Ser 
        835                 840                 845             

Ile Lys Gln Arg Asn Pro Tyr Val Asp Pro Leu Ser Phe Val Gln Ile 
    850                 855                 860                 

Glu Leu Leu Arg Arg Leu Arg Thr Asp Pro Asp Gly Leu Glu His Ser 
865                 870                 875                 880 

Asp Leu Glu Asp Ala Ile Leu Leu Ser Ile Asn Gly Ile Ala Ala Gly 
                885                 890                 895     

Leu Lys Asn Thr Gly 
            900     

<210>   347
<211>   923
<212>   PRT
<213>   Roseiflexus sp. RS-1

<400>   347
Gln Ala Gly Glu Glu Ala Phe Arg Leu Val Glu Gln Leu Arg Thr Leu 
                5                   10                  15      

Gly Lys Glu Leu Arg Asn Gly Glu Pro Asp Arg Ala Asp Ala Ser Leu 
            20                  25                  30          

Arg Ala Leu Ala Ser Gln Met Thr Val Thr Asp Val Gln Thr Val Ile 
        35                  40                  45              

Lys Ala Phe Asn Ala Tyr Phe Leu Leu Val Asn Leu Ala Glu Gln Met 
    50                  55                  60                  

Gln Arg Val Trp Ile Leu Arg Asp Arg Glu Gln Ala Ser Pro Thr Ala 
65                  70                  75                  80  

Pro Arg Thr Glu Ser Ile Ala Ala Ala Ile Ala Glu Ile His Ala His 
                85                  90                  95      

Asn Val Ser Ala Val Thr Val Gln Glu Trp Leu Glu Thr Ala Arg Ile 
            100                 105                 110         

Gln Pro Val Phe Thr Ala His Pro Thr Glu Ala Arg Arg Arg Thr Ala 
        115                 120                 125             

Leu Glu Lys Val Arg Arg Leu Ala Thr Leu Leu Asp Arg Arg Ser Gly 
    130                 135                 140                 

Gly Leu Gln Gly Phe Glu Leu Glu Glu Asn Thr Leu Arg Ile Arg Glu 
145                 150                 155                 160 

Glu Ile Val Ser Leu Trp Gln Thr Asp Glu Val Arg Val Val Lys Pro 
                165                 170                 175     

Thr Val Ile Asp Glu Val Lys Asn Gly Leu Phe Tyr Phe Glu Ser Gly 
            180                 185                 190         

Leu Phe Asp Leu Ile Pro Arg Leu Tyr Arg Glu Leu Glu Tyr Ala Leu 
        195                 200                 205             

Arg Thr Ala Tyr Pro Asp His Glu Trp Arg Val Pro Pro Leu Leu Arg 
    210                 215                 220                 

Tyr Gly Ala Trp Met Gly Gly Asp Arg Asp Gly Asn Pro Asn Val Thr 
225                 230                 235                 240 

His Ala Val Thr Leu Gln Thr Val Arg Leu Leu Arg Ala Ala Ala Val 
                245                 250                 255     

Gln Arg His Ile Thr Thr Ile Glu Glu Leu Ser His Arg Leu Gly Gln 
            260                 265                 270         

Ser Thr Arg Gln Ala Pro Val Ser Glu Glu Leu Arg Ala Ser Leu Ala 
        275                 280                 285             

Asn Asp Ala Ala Leu Phe Pro Asp Val Ala Asp Met Leu Thr Gln Arg 
    290                 295                 300                 

Asn Pro Tyr Glu Leu Tyr Arg Gln Lys Cys Thr Tyr Ile Arg Glu Lys 
305                 310                 315                 320 

Leu Leu Arg Thr Leu Asn Asp Ala Asn Thr Ala Ser Leu Asp Trp Gly 
                325                 330                 335     

Arg Ser Asp Pro Pro Pro Asn Gly Ala Tyr Leu Arg Ser Asp Asp Leu 
            340                 345                 350         

Leu Ala Asp Leu Arg Val Met Glu Gln Ser Leu Arg Ala Asn Asn Ala 
        355                 360                 365             

Ala Val Val Ala Asp Gly Ala Leu Arg Asp Leu Ile Arg Gln Val Glu 
    370                 375                 380                 

Val Phe Gly Leu His Thr Ala Thr Leu Asp Ile Arg Gln His Ser Glu 
385                 390                 395                 400 

Arg His Thr Ala Ala Leu Ala Glu Val Leu Ala Ser Ala Gly Val Cys 
                405                 410                 415     

Ala Asp Tyr Thr Ala Leu Asn Glu Thr Glu Arg Ile Asp Leu Leu Ser 
            420                 425                 430         

Arg Glu Ile Gly Asn Pro Arg Pro Leu Ile Pro Ala His Leu Asp Tyr 
        435                 440                 445             

Ser Pro Asp Thr Val Glu Val Ile Gln Thr Phe Arg Thr Ile Ala Ala 
    450                 455                 460                 

Ile Leu Asn Arg Leu Ser Pro Glu Ala Ile Glu Thr Tyr Ile Val Ser 
465                 470                 475                 480 

Met Thr Arg Gly Ala Ser Asp Leu Leu Ala Pro Leu Leu Leu Ala Lys 
                485                 490                 495     

Glu Ala Gly Leu Phe Arg Pro Phe Arg Phe Ser Arg Leu Asn Ile Ala 
            500                 505                 510         

Pro Leu Phe Glu Thr Gly Ala Asp Leu Thr Cys Cys Asp Thr Ile Leu 
        515                 520                 525             

Glu Ala Cys Leu Ser Leu Pro Val Tyr Arg Asp His Leu Ala Leu Arg 
    530                 535                 540                 

Gly Asn Leu Gln Glu Val Met Ile Gly Tyr Ser Asp Ser Asn Lys Asp 
545                 550                 555                 560 

Val Gly Tyr Val Ala Ala Asn Trp Ala Leu Tyr Gln Ala Gln Arg Lys 
                565                 570                 575     

Leu Arg Asp Phe Gly Arg Arg Tyr Gly Ile His Met Arg Leu Phe His 
            580                 585                 590         

Gly Arg Gly Gly Ala Ile Gly Arg Gly Gly Gly Pro Ala Asn His Ala 
        595                 600                 605             

Ile Leu Ala Gln Pro Pro Gly Ser Ile Gly Asn Gln Ile Lys Ile Thr 
    610                 615                 620                 

Glu Gln Gly Glu Val Ile Ala Asp Arg Tyr Gly Leu Pro Leu Leu Ala 
625                 630                 635                 640 

His Arg His Ile Glu Gln Val Met Asn Ala Val Leu Arg Ala Gly Leu 
                645                 650                 655     

Leu Gln Arg Asp Asp Pro Pro Ala Glu Trp Met Gln Ala Leu Glu Arg 
            660                 665                 670         

Leu Ala Asp Leu Ser Gln Arg His Tyr Arg Ala Leu Val Tyr Glu Arg 
        675                 680                 685             

Asn Asp Phe Val Pro Tyr Phe His Asn Val Thr Pro Ile Thr Glu Ile 
    690                 695                 700                 

Ser Arg Leu Asn Ile Gly Ser Arg Pro Ala Ser Arg Arg Asn Thr Gly 
705                 710                 715                 720 

Arg Ile Glu Asp Leu Arg Ala Ile Pro Trp Val Phe Ser Trp Met Gln 
                725                 730                 735     

Ser Arg His Thr Leu Pro Gly Trp Tyr Gly Met Gly Phe Ala Leu Glu 
            740                 745                 750         

Thr Phe Val Tyr Lys Gly Asp Gly Ile Asp Leu Asp Met Ser Gly Asp 
        755                 760                 765             

Ser Gly Asn Val Thr Gly Asp Gly Thr Thr Asp His Val Gly Ser Ala 
    770                 775                 780                 

Ile Asp Arg Leu Ala Leu Leu Gln Glu Met Tyr Ala Arg Trp Ser Phe 
785                 790                 795                 800 

Phe Arg Val Met Ile Asp Asn Ala Gln Met Ile Leu Gly Lys Ala Asp 
                805                 810                 815     

Leu His Ile Ala Ala Arg Tyr Ala Glu Leu Ala Pro Asp Arg Glu Ala 
            820                 825                 830         

Ala Ala Ser Ile Phe Ala Ala Ile Arg Asp Glu Tyr Gly Arg Thr Asp 
        835                 840                 845             

Arg Met Ile Arg Gln Ile Ala Arg Ile Glu Arg Leu Leu Asp Asn Ser 
    850                 855                 860                 

Pro Val Leu Gln His Ser Ile Gln Arg Arg Asn Pro Tyr Ile Asp Pro 
865                 870                 875                 880 

Met Ser Tyr Leu Gln Ile Glu Leu Leu Arg Arg Leu Arg Ala Ala Pro 
                885                 890                 895     

Asp Gly Pro Gln His Ala Ala Ile Glu Asp Ala Ile Leu Leu Ser Ile 
            900                 905                 910         

Ser Gly Leu Ala Ala Gly Leu Met Asn Thr Gly 
        915                 920             

<210>   348
<211>   906
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   348
Met Ala Asn Asp Ala Pro Leu His Arg Asp Ile Arg Val Leu Gly Asp 
                5                   10                  15      

Leu Leu Gly Glu Val Leu Val Glu Gln Cys Gly Arg Arg Val Phe Asp 
            20                  25                  30          

His Val Glu Ser Ile Arg Leu Ala Ala Lys Ala Phe Arg Ala Asp Pro 
        35                  40                  45              

Ser Pro Glu Thr Arg Ala Ala Leu Gln Ala Ala Val Ser Ala Val Glu 
    50                  55                  60                  

Pro Glu His Arg Asn Asp Val Ile His Ala Phe Ser Val Tyr Phe Gln 
65                  70                  75                  80  

Leu Val Asn Leu Ala Glu Gln Asn His Arg Leu Arg Arg His Arg Asp 
                85                  90                  95      

Tyr Asp Arg Ser Gln Gln Val Leu Arg Gly Ser Phe Arg Glu Thr Met 
            100                 105                 110         

Arg Thr Leu Ala Asp Arg Gly Met Thr Ala Asp Asp Ile Glu Ser Leu 
        115                 120                 125             

Leu Arg Glu Val Gly Ile Glu Leu Val Leu Thr Ala His Pro Thr Glu 
    130                 135                 140                 

Ala Leu Arg Arg Thr Val Leu Asp Lys His Thr Lys Ile Ala Ala Phe 
145                 150                 155                 160 

Leu Glu Asp Met Asp Asp Pro Arg Lys Thr Pro Arg Glu Leu Asp Val 
                165                 170                 175     

Leu Arg Glu Arg Ile Arg Thr Glu Ile Val Ala Leu Trp Gln Thr Arg 
            180                 185                 190         

Ser Val Arg Lys Gln Arg Ile Thr Val Leu Asp Glu Val Arg Asn Gly 
        195                 200                 205             

Leu Tyr Phe Leu Asp Gln Ile Leu Phe Asp Val Leu Pro Arg Val His 
    210                 215                 220                 

Gln Lys Leu Glu Gln Ala Val Glu Glu Gln Phe Gly Arg Gln Leu Leu 
225                 230                 235                 240 

Glu Leu Pro Pro Leu Ile Arg Phe Gly Ser Trp Met Gly Gly Asp Arg 
                245                 250                 255     

Asp Gly Asn Pro Asn Val Thr Ser Asp Ile Thr Trp Gln Thr Leu Val 
            260                 265                 270         

Leu His Cys Asp Leu Ala Leu Asn Lys Tyr Glu Gln Lys Leu Arg Glu 
        275                 280                 285             

Leu Gly Arg Asp Leu Ser Val Ser Val Asp Arg Ala Gly Ala Asp Glu 
    290                 295                 300                 

Asp Leu Leu Ala Ser Leu Gly Gly Glu Asn Asp Glu Pro Tyr Arg Ala 
305                 310                 315                 320 

Leu Ile Asn Arg Met Leu Glu Arg Leu Ala Asn Thr Arg Arg Arg Leu 
                325                 330                 335     

His Gly Glu Arg Val Asp Gly Pro Asp Tyr Ala Ser Pro Glu Ala Met 
            340                 345                 350         

Met Glu Asp Val Glu Arg Met Ala Arg Ser Leu Ala His His Arg Gly 
        355                 360                 365             

Gln Arg Met Val Asp Ala Trp Leu Arg Pro Phe Leu Leu Gln Leu Arg 
    370                 375                 380                 

Ile Phe Gly Phe His Met Val Thr Leu Asp Ile Arg Gln His Ser Gly 
385                 390                 395                 400 

Val His Glu Gln Ala Val Ala Glu Leu Leu Gln Thr Ala Gly Leu Val 
                405                 410                 415     

Asp Asp Tyr Thr Ser Leu Gly Glu Asp Glu Arg Val Arg Val Leu Ser 
            420                 425                 430         

Glu Cys Leu Ala Ser Pro Arg Pro Ile Arg Asn Pro Tyr His Val Tyr 
        435                 440                 445             

Ser Asp Val Thr Thr Glu Ala Leu Ala Val Leu Asp Cys Val Arg Arg 
    450                 455                 460                 

Gly His Glu Thr Phe Gly Pro Arg Cys Val Gln Asp Tyr Leu Ile Ser 
465                 470                 475                 480 

Met Thr Gln Gly Ala Ser Asp Leu Leu Glu Val Leu Leu Leu Ala Lys 
                485                 490                 495     

Glu Ser Gly Leu Phe Gly Trp Pro Asp Gly Pro Met Ala Pro Pro Lys 
            500                 505                 510         

Ser Asp Leu Asn Val Val Pro Leu Phe Glu Thr Ile Glu Asp Leu Glu 
        515                 520                 525             

Ser Ala Ala Gly Ile Met Arg Ser Leu Phe Glu Asn Pro Val Tyr Arg 
    530                 535                 540                 

Arg His Leu Glu Met Arg Gly Trp Gln Gln Glu Ile Met Leu Gly Tyr 
545                 550                 555                 560 

Ser Asp Ser Asn Lys Asp Gly Gly Tyr Leu Thr Ala Asn Trp Ser Leu 
                565                 570                 575     

Tyr Met Ala Gln Lys His Leu Ile Arg Leu Ala Glu Ala Tyr Gly Val 
            580                 585                 590         

Arg Ile Lys Phe Phe His Gly Arg Gly Gly Ala Leu Gly Arg Gly Gly 
        595                 600                 605             

Gly Pro Val Glu Gln Ser Ile Leu Ala Gln Pro Thr Glu Ala Leu Arg 
    610                 615                 620                 

Gly His Val Lys Ile Thr Glu Gln Gly Glu Val Ile Ser Gln Arg Tyr 
625                 630                 635                 640 

Gly His Pro Gly Ile Ala Glu Arg Ser Leu Glu Ser Ser Ala Ala Ala 
                645                 650                 655     

Val Leu Val Gly Ala Thr Arg Glu Asp Ser Glu Glu Trp Ala Glu Arg 
            660                 665                 670         

His Pro Arg Trp Phe Arg Leu Leu Asp Arg Ala Ser Glu Ile Ser Phe 
        675                 680                 685             

Arg Ala Tyr Arg Lys Leu Val Phe Glu His Pro Ala Phe Leu Glu Tyr 
    690                 695                 700                 

Phe His Arg Ala Thr Pro Ile Asp Glu Ile Gly Lys Met Asn Ile Gly 
705                 710                 715                 720 

Ser Arg Pro Ser Arg Arg Ser Gln Ser Ala Arg Ile Glu Asp Leu Arg 
                725                 730                 735     

Ala Ile Pro Trp Val Phe Ser Trp Thr Gln Ser Arg His Leu Leu Pro 
            740                 745                 750         

Ala Trp Tyr Gly Phe Gly Ser Ala Ile Glu Ala Ile Met Arg Glu Asp 
        755                 760                 765             

Pro Arg Ala Leu Glu Asp Leu Arg Arg Met Tyr Glu Val Trp Pro Phe 
    770                 775                 780                 

Phe Arg Thr Leu Val Asp Asn Leu Gln Met Ala Leu Ala Lys Ala Asp 
785                 790                 795                 800 

Met Leu Val Ala Lys Glu Tyr Ala Gln Leu Ala Gly Glu Ala Gly Glu 
                805                 810                 815     

Ala Val Phe Pro Leu Ile Glu Glu Glu Tyr Ala Arg Thr Glu Arg Ala 
            820                 825                 830         

Val Leu Asp Ile Thr Gly Tyr Arg Gln Leu Leu Asp Asn Arg Pro Val 
        835                 840                 845             

Ile Arg Glu Ser Ile Ser Leu Arg Asn Pro Tyr Val Asp Pro Leu Ser 
    850                 855                 860                 

Phe Phe Gln Val Arg Leu Leu Ala Asp Leu Arg Thr Asp Asn Leu Ser 
865                 870                 875                 880 

Pro Glu Glu Arg Glu Ala Glu Leu Ala Asp Ala Leu Gln Thr Ile Asn 
                885                 890                 895     

Gly Ile Ala Ala Gly Leu Arg Asn Thr Gly 
            900                 905     

<210>   349
<211>   906
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   349
Met Ala Asn Asp Ala Pro Leu His Arg Asp Ile Arg Val Leu Gly Asp 
                5                   10                  15      

Leu Leu Gly Glu Val Leu Val Glu Gln Cys Gly Arg Arg Val Phe Asp 
            20                  25                  30          

His Val Glu Ser Ile Arg Leu Ala Ala Lys Ala Phe Arg Ala Asp Pro 
        35                  40                  45              

Ser Pro Glu Thr Arg Ala Ala Leu Gln Ala Ala Val Ser Ala Val Glu 
    50                  55                  60                  

Pro Glu His Arg Asn Asp Val Ile His Ala Phe Ser Val Tyr Phe Gln 
65                  70                  75                  80  

Leu Val Asn Leu Ala Glu Gln Asn His Arg Leu Arg Arg His Arg Asp 
                85                  90                  95      

Tyr Asp Arg Ser Gln Gln Ile Leu Arg Gly Ser Phe Arg Glu Thr Met 
            100                 105                 110         

Arg Thr Leu Ala Asp Arg Gly Met Thr Ala Asp Asp Ile Glu Ser Leu 
        115                 120                 125             

Leu Arg Glu Val Gly Ile Glu Leu Val Leu Thr Ala His Pro Thr Glu 
    130                 135                 140                 

Ala Leu Arg Arg Thr Val Leu Asp Lys His Thr Lys Ile Ala Ala Phe 
145                 150                 155                 160 

Leu Glu Asp Met Asp Asp Pro Arg Lys Thr Pro Arg Glu Leu Asp Val 
                165                 170                 175     

Leu Arg Glu Arg Ile Arg Thr Glu Ile Val Ala Leu Trp Gln Thr Arg 
            180                 185                 190         

Ser Val Arg Lys Gln Arg Ile Thr Val Leu Asp Glu Val Arg Asn Gly 
        195                 200                 205             

Leu Tyr Phe Leu Asp Gln Ile Leu Phe Asp Val Leu Pro Arg Val His 
    210                 215                 220                 

Gln Lys Leu Glu Gln Ala Val Glu Glu Gln Phe Gly Arg Gln Leu Leu 
225                 230                 235                 240 

Glu Leu Pro Pro Leu Ile Arg Phe Gly Ser Trp Met Gly Gly Asp Arg 
                245                 250                 255     

Asp Gly Asn Pro Asn Val Thr Ser Asp Ile Thr Trp Gln Thr Leu Val 
            260                 265                 270         

Leu His Cys Asp Leu Ala Leu Asn Lys Tyr Glu Gln Lys Leu Arg Glu 
        275                 280                 285             

Leu Gly Arg Asp Leu Ser Val Ser Val Asp Arg Ala Gly Ala Asp Glu 
    290                 295                 300                 

Asp Leu Leu Ala Ser Leu Gly Gly Glu Asn Asp Glu Pro Tyr Arg Ala 
305                 310                 315                 320 

Leu Ile Asn Arg Met Leu Glu Arg Leu Ala Asn Thr Arg Arg Arg Leu 
                325                 330                 335     

His Gly Glu Arg Val Asp Gly Pro Asp Tyr Ala Ser Pro Glu Ala Met 
            340                 345                 350         

Met Glu Asp Val Glu Arg Met Ala Arg Ser Leu Ala His His Arg Gly 
        355                 360                 365             

Gln Arg Met Val Asp Ala Trp Leu Arg Pro Phe Leu Leu Gln Leu Arg 
    370                 375                 380                 

Ile Phe Gly Phe His Met Val Thr Leu Asp Ile Arg Gln His Ser Gly 
385                 390                 395                 400 

Val His Glu Gln Ala Val Ala Glu Leu Leu Gln Thr Ala Gly Leu Val 
                405                 410                 415     

Asp Asp Tyr Thr Ser Leu Gly Glu Glu Glu Arg Val Arg Val Leu Ser 
            420                 425                 430         

Glu Cys Leu Ala Ser Pro Arg Pro Ile Arg Asn Pro Tyr His Val Tyr 
        435                 440                 445             

Ser Asp Val Thr Thr Glu Ala Leu Ala Val Leu Asp Cys Val Arg Arg 
    450                 455                 460                 

Gly His Glu Thr Phe Gly Pro Arg Cys Val Gln Asp Tyr Leu Ile Ser 
465                 470                 475                 480 

Met Thr Gln Gly Ala Ser Asp Leu Leu Glu Val Leu Leu Leu Ala Lys 
                485                 490                 495     

Glu Ser Gly Leu Phe Gly Trp Pro Asp Gly Pro Met Ala Pro Pro Lys 
            500                 505                 510         

Ser Asp Leu Asn Val Val Pro Leu Phe Glu Thr Ile Glu Asp Leu Glu 
        515                 520                 525             

Ser Ala Ala Gly Ile Met Arg Ser Leu Phe Glu Asn Pro Val Tyr Arg 
    530                 535                 540                 

Arg His Leu Glu Met Arg Gly Trp Gln Gln Glu Ile Met Leu Gly Tyr 
545                 550                 555                 560 

Ser Asp Ser Asn Lys Asp Gly Gly Tyr Leu Thr Ala Asn Trp Ser Leu 
                565                 570                 575     

Tyr Met Ala Gln Lys His Leu Ile Arg Leu Ala Glu Ala Tyr Gly Val 
            580                 585                 590         

Arg Ile Lys Phe Phe His Gly Arg Gly Gly Ala Leu Gly Arg Gly Gly 
        595                 600                 605             

Gly Pro Val Glu Gln Ser Ile Leu Ala Gln Pro Thr Glu Ala Leu Arg 
    610                 615                 620                 

Gly His Val Lys Ile Thr Glu Gln Gly Glu Val Ile Ser Gln Arg Tyr 
625                 630                 635                 640 

Gly His Pro Gly Ile Ala Glu Arg Ser Leu Glu Ser Ser Ala Ala Ala 
                645                 650                 655     

Val Leu Val Gly Ala Thr Arg Glu Asp Ser Glu Glu Trp Ala Glu Arg 
            660                 665                 670         

His Pro Arg Trp Phe Arg Leu Leu Asp Arg Ala Ser Glu Ile Ser Phe 
        675                 680                 685             

Arg Ala Tyr Arg Lys Leu Val Phe Glu His Pro Ala Phe Leu Glu Tyr 
    690                 695                 700                 

Phe His Arg Ala Thr Pro Ile Asp Glu Ile Gly Lys Met Asn Ile Gly 
705                 710                 715                 720 

Ser Arg Pro Ser Arg Arg Ser Gln Ser Ala Arg Ile Glu Asp Leu Arg 
                725                 730                 735     

Ala Ile Pro Trp Val Phe Ser Trp Thr Gln Ser Arg His Leu Leu Pro 
            740                 745                 750         

Ala Trp Tyr Gly Phe Gly Ser Ala Ile Glu Ala Ile Met Arg Glu Asp 
        755                 760                 765             

Pro Arg Ala Leu Glu Asp Leu Arg Arg Met Tyr Glu Val Trp Pro Phe 
    770                 775                 780                 

Phe Arg Thr Leu Val Asp Asn Leu Gln Met Ala Leu Ala Lys Ala Asp 
785                 790                 795                 800 

Met Leu Val Ala Lys Glu Tyr Ala Gln Leu Ala Gly Glu Ala Gly Glu 
                805                 810                 815     

Ala Val Phe Pro Leu Ile Glu Glu Glu Tyr Ala Arg Thr Glu Arg Ala 
            820                 825                 830         

Val Leu Asp Ile Thr Gly Tyr Arg Gln Leu Leu Asp Asn Arg Pro Val 
        835                 840                 845             

Ile Arg Glu Ser Ile Ser Leu Arg Asn Pro Tyr Val Asp Pro Leu Ser 
    850                 855                 860                 

Phe Phe Gln Val Arg Leu Leu Ala Asp Leu Arg Thr Asp Asn Leu Ser 
865                 870                 875                 880 

Pro Glu Glu Arg Glu Ala Glu Leu Ala Asp Ala Leu Gln Thr Ile Asn 
                885                 890                 895     

Gly Ile Ala Ala Gly Leu Arg Asn Thr Gly 
            900                 905     

<210>   350
<211>   906
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   350
Met Ala Asn Asp Ala Pro Leu His Arg Asp Ile Arg Val Leu Gly Asp 
                5                   10                  15      

Leu Leu Gly Glu Val Leu Val Glu Gln Cys Gly Lys Arg Val Phe Asp 
            20                  25                  30          

His Val Glu Ser Ile Arg Leu Ala Ala Lys Ala Phe Arg Ala Asp Pro 
        35                  40                  45              

Ser Pro Glu Thr Arg Ala Ala Leu Gln Ala Ala Val Ser Ala Val Glu 
    50                  55                  60                  

Pro Glu His Arg Asn Asp Val Ile His Ala Phe Ser Val Tyr Phe Gln 
65                  70                  75                  80  

Leu Val Asn Leu Ala Glu Gln Asn His Arg Leu Arg Arg His Arg Asp 
                85                  90                  95      

Tyr Asp Arg Ser Gln Gln Val Leu Arg Gly Ser Phe Arg Glu Thr Met 
            100                 105                 110         

Arg Thr Leu Ala Asp Arg Gly Met Thr Ala Asp Asp Ile Glu Ser Leu 
        115                 120                 125             

Leu Arg Glu Val Gly Ile Glu Leu Val Leu Thr Ala His Pro Thr Glu 
    130                 135                 140                 

Ala Leu Arg Arg Thr Val Leu Asp Lys His Thr Lys Ile Ala Ala Phe 
145                 150                 155                 160 

Leu Glu Asp Met Asp Asp Pro Arg Lys Thr Pro Arg Glu Leu Asp Val 
                165                 170                 175     

Leu Arg Glu Arg Ile Arg Thr Glu Ile Val Ala Leu Trp Gln Thr Arg 
            180                 185                 190         

Ser Val Arg Lys Gln Arg Ile Thr Val Leu Asp Glu Val Arg Asn Gly 
        195                 200                 205             

Leu Tyr Phe Leu Asp Gln Ile Leu Phe Asp Val Leu Pro Arg Val His 
    210                 215                 220                 

Gln Lys Leu Glu Gln Ala Val Glu Glu Gln Phe Gly Arg Gln Leu Leu 
225                 230                 235                 240 

Glu Leu Pro Pro Leu Ile Arg Phe Gly Ser Trp Met Gly Gly Asp Arg 
                245                 250                 255     

Asp Gly Asn Pro Asn Val Thr Ser Asp Ile Thr Trp Gln Thr Leu Val 
            260                 265                 270         

Leu His Cys Asp Leu Ala Leu Asn Lys Tyr Glu Gln Lys Leu Arg Glu 
        275                 280                 285             

Leu Gly Arg Asp Leu Ser Val Ser Val Asp Arg Ala Gly Ala Asp Glu 
    290                 295                 300                 

Asp Leu Leu Ala Ser Leu Gly Gly Glu Asn Asp Glu Pro Tyr Arg Ala 
305                 310                 315                 320 

Leu Ile Asn Arg Met Leu Glu Arg Leu Ala Asn Thr Arg Arg Arg Leu 
                325                 330                 335     

His Gly Glu Arg Val Asp Gly Pro Asp Tyr Ala Ser Pro Glu Ala Met 
            340                 345                 350         

Met Glu Asp Val Glu Arg Met Ala Arg Ser Leu Ala His His Arg Gly 
        355                 360                 365             

Gln Arg Met Val Asp Ala Trp Leu Arg Pro Phe Leu Leu Gln Leu Arg 
    370                 375                 380                 

Ile Phe Gly Phe His Met Val Thr Leu Asp Ile Arg Gln His Ser Gly 
385                 390                 395                 400 

Val His Glu Gln Ala Val Ala Glu Leu Leu Gln Thr Ala Gly Leu Val 
                405                 410                 415     

Asp Asp Tyr Thr Ser Leu Gly Glu Glu Glu Arg Val Arg Val Leu Ser 
            420                 425                 430         

Glu Cys Leu Ala Ser Pro Arg Pro Ile Arg Asn Pro Tyr His Val Tyr 
        435                 440                 445             

Ser Asp Val Thr Thr Glu Ala Leu Ala Val Leu Asp Cys Val Arg Arg 
    450                 455                 460                 

Gly His Glu Thr Phe Gly Pro Arg Cys Val Gln Asp Tyr Leu Ile Ser 
465                 470                 475                 480 

Met Thr Gln Gly Ala Ser Asp Leu Leu Glu Val Leu Leu Leu Ala Lys 
                485                 490                 495     

Glu Ser Gly Leu Phe Gly Trp Pro Asp Gly Pro Met Ala Pro Pro Lys 
            500                 505                 510         

Ser Asp Leu Asn Val Val Pro Leu Phe Glu Thr Ile Glu Asp Leu Glu 
        515                 520                 525             

Ser Ala Ala Gly Ile Met Arg Ser Leu Phe Glu Asn Pro Val Tyr Arg 
    530                 535                 540                 

Arg His Leu Glu Met Arg Gly Trp Gln Gln Glu Ile Met Leu Gly Tyr 
545                 550                 555                 560 

Ser Asp Ser Asn Lys Asp Gly Gly Tyr Leu Thr Ala Asn Trp Ser Leu 
                565                 570                 575     

Tyr Met Ala Gln Lys His Leu Ile Arg Leu Ala Glu Ala Tyr Gly Val 
            580                 585                 590         

Arg Ile Lys Phe Phe His Gly Arg Gly Gly Ala Leu Gly Arg Gly Gly 
        595                 600                 605             

Gly Pro Val Glu Gln Ser Ile Leu Ala Gln Pro Thr Glu Ala Leu Arg 
    610                 615                 620                 

Gly His Val Lys Ile Thr Glu Gln Gly Glu Val Ile Ser Gln Arg Tyr 
625                 630                 635                 640 

Gly His Pro Gly Ile Ala Glu Arg Ser Leu Glu Ser Ser Ala Ala Ala 
                645                 650                 655     

Val Leu Val Gly Ala Thr Arg Glu Asp Ser Glu Glu Trp Ala Glu Arg 
            660                 665                 670         

His Pro Arg Trp Phe Arg Leu Leu Asp Arg Ala Ser Glu Ile Ser Phe 
        675                 680                 685             

Arg Ala Tyr Arg Lys Leu Val Phe Glu His Pro Ala Phe Leu Glu Tyr 
    690                 695                 700                 

Phe His Arg Ala Thr Pro Ile Asp Glu Ile Gly Lys Met Asn Ile Gly 
705                 710                 715                 720 

Ser Arg Pro Ser Arg Arg Ser Gln Ser Ala Arg Ile Glu Asp Leu Arg 
                725                 730                 735     

Ala Ile Pro Trp Val Phe Ser Trp Thr Gln Ser Arg His Leu Leu Pro 
            740                 745                 750         

Ala Trp Tyr Gly Phe Gly Ser Ala Ile Glu Ala Ile Met Arg Glu Asp 
        755                 760                 765             

Pro Arg Ala Leu Glu Asp Leu Arg Arg Met Tyr Glu Val Trp Pro Phe 
    770                 775                 780                 

Phe Arg Thr Leu Val Asp Asn Leu Gln Met Ala Leu Ala Lys Ala Asp 
785                 790                 795                 800 

Met Leu Val Ala Lys Glu Tyr Ala Gln Leu Ala Gly Glu Ala Gly Glu 
                805                 810                 815     

Ala Val Phe Pro Leu Ile Glu Glu Glu Tyr Ala Arg Thr Glu Arg Ala 
            820                 825                 830         

Val Leu Asp Ile Thr Gly Tyr Arg Gln Leu Leu Asp Asn Arg Pro Val 
        835                 840                 845             

Ile Arg Glu Ser Ile Ser Leu Arg Asn Pro Tyr Val Asp Pro Leu Ser 
    850                 855                 860                 

Phe Phe Gln Val Arg Leu Leu Ala Asp Leu Arg Thr Asp Asn Leu Ser 
865                 870                 875                 880 

Pro Glu Glu Arg Glu Ala Glu Leu Ala Asp Ala Leu Gln Thr Ile Asn 
                885                 890                 895     

Gly Ile Ala Ala Gly Leu Arg Asn Thr Gly 
            900                 905     

<210>   351
<211>   906
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   351
Met Ala Asn Asp Ala Pro Leu His Arg Asp Ile Arg Val Leu Gly Asp 
                5                   10                  15      

Leu Leu Gly Glu Val Leu Val Glu Gln Cys Gly Arg Arg Val Phe Asp 
            20                  25                  30          

His Val Glu Ser Ile Arg Leu Ala Ala Lys Ala Phe Arg Ala Asp Pro 
        35                  40                  45              

Ser Pro Glu Thr Arg Ala Ala Leu Gln Ala Ala Val Ser Ala Val Glu 
    50                  55                  60                  

Pro Glu His Arg Asn Asp Val Ile His Ala Phe Ser Val Tyr Phe Gln 
65                  70                  75                  80  

Leu Val Asn Leu Ala Glu Gln Asn His Arg Leu Arg Arg His Arg Asp 
                85                  90                  95      

Tyr Asp Arg Ser Gln Gln Val Leu Arg Gly Ser Phe Arg Glu Thr Met 
            100                 105                 110         

Arg Thr Leu Ala Asp Arg Gly Met Thr Ala Asp Asp Ile Glu Ser Leu 
        115                 120                 125             

Leu Arg Glu Val Gly Ile Glu Leu Val Leu Thr Ala His Pro Thr Glu 
    130                 135                 140                 

Ala Leu Arg Arg Thr Val Leu Asp Lys His Thr Lys Ile Ala Ala Phe 
145                 150                 155                 160 

Leu Glu Asp Met Asp Asp Pro Arg Lys Thr Pro Arg Glu Leu Asp Val 
                165                 170                 175     

Leu Arg Glu Arg Ile Arg Thr Glu Ile Val Ala Leu Trp Gln Thr Arg 
            180                 185                 190         

Ser Val Arg Lys Gln Arg Ile Thr Val Leu Asp Glu Val Arg Asn Gly 
        195                 200                 205             

Leu Tyr Phe Leu Asp Gln Ile Leu Phe Asp Val Leu Pro Arg Val His 
    210                 215                 220                 

Gln Lys Leu Glu Gln Ala Val Glu Glu Gln Phe Gly Arg Gln Leu Leu 
225                 230                 235                 240 

Glu Leu Pro Pro Leu Ile Arg Phe Gly Ser Trp Met Gly Gly Asp Arg 
                245                 250                 255     

Asp Gly Asn Pro Asn Val Thr Ser Asp Ile Thr Trp Gln Thr Leu Val 
            260                 265                 270         

Leu His Cys Asp Leu Ala Leu Asn Lys Tyr Glu Gln Lys Leu Arg Asp 
        275                 280                 285             

Leu Gly Arg Asp Leu Ser Val Ser Val Asp Arg Ala Gly Ala Asp Glu 
    290                 295                 300                 

Asp Leu Leu Ala Ser Leu Gly Gly Glu Asn Asp Glu Pro Tyr Arg Ala 
305                 310                 315                 320 

Leu Ile Asn Arg Met Leu Glu Arg Leu Ala Asn Thr Arg Arg Arg Leu 
                325                 330                 335     

His Gly Glu Arg Val Asp Gly Pro Asp Tyr Ala Ser Pro Glu Ala Met 
            340                 345                 350         

Met Glu Asp Val Glu Arg Met Ala Arg Ser Leu Ala His His Arg Gly 
        355                 360                 365             

Gln Arg Met Val Asp Ala Trp Leu Arg Pro Phe Leu Leu Gln Leu Arg 
    370                 375                 380                 

Ile Phe Gly Phe His Met Val Thr Leu Asp Ile Arg Gln His Ser Gly 
385                 390                 395                 400 

Val His Glu Gln Ala Val Ala Glu Leu Leu Gln Thr Ala Gly Leu Val 
                405                 410                 415     

Asp Asp Tyr Thr Ser Leu Gly Glu Glu Glu Arg Val Arg Val Leu Ser 
            420                 425                 430         

Glu Cys Leu Ala Ser Pro Arg Pro Ile Arg Asn Pro Tyr His Val Tyr 
        435                 440                 445             

Ser Asp Val Thr Thr Glu Ala Leu Ala Val Leu Asp Cys Val Arg Arg 
    450                 455                 460                 

Gly His Glu Thr Phe Gly Pro Arg Cys Val Gln Asp Tyr Leu Ile Ser 
465                 470                 475                 480 

Met Thr Gln Gly Ala Ser Asp Leu Leu Glu Val Leu Leu Leu Ala Lys 
                485                 490                 495     

Glu Ser Gly Leu Phe Gly Trp Pro Asp Gly Pro Met Ala Pro Pro Lys 
            500                 505                 510         

Ser Asp Leu Asn Val Val Pro Leu Phe Glu Thr Ile Glu Asp Leu Glu 
        515                 520                 525             

Ser Ala Ala Gly Ile Met Arg Ser Leu Phe Glu Asn Pro Val Tyr Arg 
    530                 535                 540                 

Arg His Leu Glu Met Arg Gly Trp Gln Gln Glu Ile Met Leu Gly Tyr 
545                 550                 555                 560 

Ser Asp Ser Asn Lys Asp Gly Gly Tyr Leu Thr Ala Asn Trp Ser Leu 
                565                 570                 575     

Tyr Met Ala Gln Lys His Leu Ile Arg Leu Ala Glu Ala Tyr Gly Val 
            580                 585                 590         

Arg Ile Lys Phe Phe His Gly Arg Gly Gly Ala Leu Gly Arg Gly Gly 
        595                 600                 605             

Gly Pro Val Glu Gln Ser Ile Leu Ala Gln Pro Thr Glu Ala Leu Arg 
    610                 615                 620                 

Gly His Val Lys Ile Thr Glu Gln Gly Glu Val Ile Ser Gln Arg Tyr 
625                 630                 635                 640 

Gly His Pro Gly Ile Ala Glu Arg Ser Leu Glu Ser Ser Ala Ala Ala 
                645                 650                 655     

Val Leu Val Gly Ala Thr Arg Glu Asp Ser Glu Glu Trp Ala Glu Arg 
            660                 665                 670         

His Pro Arg Trp Phe Arg Leu Leu Asp Arg Ala Ser Glu Ile Ser Phe 
        675                 680                 685             

Arg Ala Tyr Arg Lys Leu Val Phe Glu His Pro Ala Phe Leu Glu Tyr 
    690                 695                 700                 

Phe His Arg Ala Thr Pro Ile Asp Glu Ile Gly Lys Met Asn Ile Gly 
705                 710                 715                 720 

Ser Arg Pro Ser Arg Arg Ser Gln Ser Ala Arg Ile Glu Asp Leu Arg 
                725                 730                 735     

Ala Ile Pro Trp Val Phe Ser Trp Thr Gln Ser Arg His Leu Leu Pro 
            740                 745                 750         

Ala Trp Tyr Gly Phe Gly Ser Ala Ile Glu Ala Ile Met Arg Glu Asp 
        755                 760                 765             

Pro Arg Ala Leu Glu Asp Leu Arg Arg Met Tyr Glu Val Trp Pro Phe 
    770                 775                 780                 

Phe Arg Thr Leu Val Asp Asn Leu Gln Met Ala Leu Ala Lys Ala Asp 
785                 790                 795                 800 

Met Leu Val Ala Lys Glu Tyr Ala Gln Leu Ala Gly Glu Ala Gly Glu 
                805                 810                 815     

Ala Val Phe Pro Leu Ile Glu Glu Glu Tyr Ala Arg Thr Glu Arg Ala 
            820                 825                 830         

Val Leu Asp Ile Thr Gly Tyr Arg Gln Leu Leu Asp Asn Arg Pro Val 
        835                 840                 845             

Ile Arg Glu Ser Ile Ser Leu Arg Asn Pro Tyr Val Asp Pro Leu Ser 
    850                 855                 860                 

Phe Phe Gln Val Arg Leu Leu Ala Asp Leu Arg Thr Asp Asn Leu Ser 
865                 870                 875                 880 

Pro Glu Glu Arg Glu Ala Glu Leu Ala Asp Ala Leu Gln Thr Ile Asn 
                885                 890                 895     

Gly Ile Ala Ala Gly Leu Arg Asn Thr Gly 
            900                 905     

<210>   352
<211>   906
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   352
Met Ala Asn Asp Ala Pro Leu His Arg Asp Ile Arg Val Leu Gly Asp 
                5                   10                  15      

Leu Leu Gly Glu Val Leu Val Glu Gln Cys Gly Arg Arg Val Phe Asp 
            20                  25                  30          

His Val Glu Ser Ile Arg Leu Ala Ala Lys Ala Phe Arg Ala Asp Pro 
        35                  40                  45              

Ser Pro Glu Thr Arg Ala Ala Leu Gln Ala Ala Val Ser Ala Val Glu 
    50                  55                  60                  

Pro Glu His Arg Asn Asp Val Ile His Ala Phe Ser Val Tyr Phe Gln 
65                  70                  75                  80  

Leu Val Asn Leu Ala Glu Gln Asn His Arg Leu Arg Arg His Arg Asp 
                85                  90                  95      

Tyr Asp Arg Ser Gln Gln Val Leu Arg Gly Ser Phe Arg Glu Thr Met 
            100                 105                 110         

Arg Thr Leu Ala Asp Arg Gly Met Thr Ala Asp Asp Ile Glu Ser Leu 
        115                 120                 125             

Leu Arg Glu Val Gly Ile Glu Leu Val Leu Thr Ala His Pro Thr Glu 
    130                 135                 140                 

Ala Leu Arg Arg Thr Val Leu Asp Lys His Thr Lys Ile Ala Ala Phe 
145                 150                 155                 160 

Leu Glu Asp Met Asp Asp Pro Arg Lys Thr Pro Arg Glu Leu Asp Val 
                165                 170                 175     

Leu Arg Glu Arg Ile Arg Thr Glu Ile Val Ala Leu Trp Gln Thr Arg 
            180                 185                 190         

Ser Val Arg Lys Gln Arg Ile Thr Val Leu Asp Glu Val Arg Asn Gly 
        195                 200                 205             

Leu Tyr Phe Leu Asp Gln Ile Leu Phe Asp Val Leu Pro Arg Val His 
    210                 215                 220                 

Gln Lys Leu Glu Gln Ala Val Glu Glu Gln Phe Gly Arg Gln Leu Leu 
225                 230                 235                 240 

Glu Leu Pro Pro Leu Ile Arg Phe Gly Ser Trp Met Gly Gly Asp Arg 
                245                 250                 255     

Asp Gly Asn Pro Asn Val Thr Ser Asp Ile Thr Trp Gln Thr Leu Val 
            260                 265                 270         

Leu His Cys Asp Leu Ala Leu Asn Lys Tyr Glu Gln Lys Leu Arg Glu 
        275                 280                 285             

Leu Gly Arg Asp Leu Ser Val Ser Val Asp Arg Ala Gly Ala Asp Glu 
    290                 295                 300                 

Asp Leu Leu Ala Ser Leu Gly Gly Glu Asn Asp Glu Pro Tyr Arg Ala 
305                 310                 315                 320 

Leu Ile Asn Arg Met Leu Glu Arg Leu Ala Asn Thr Arg Arg Arg Leu 
                325                 330                 335     

His Gly Glu Arg Val Asp Gly Pro Asp Tyr Ala Ser Pro Glu Ala Met 
            340                 345                 350         

Met Glu Asp Val Glu Arg Met Ala Arg Ser Leu Ala His His Arg Gly 
        355                 360                 365             

Gln Arg Met Val Asp Ala Trp Leu Arg Pro Phe Leu Leu Gln Leu Arg 
    370                 375                 380                 

Ile Phe Gly Phe His Met Val Thr Leu Asp Ile Arg Gln His Ser Gly 
385                 390                 395                 400 

Val His Glu Gln Ala Val Ala Glu Leu Leu Gln Thr Ala Gly Leu Val 
                405                 410                 415     

Asp Asp Tyr Thr Ser Leu Gly Glu Glu Glu Arg Val Arg Val Leu Ser 
            420                 425                 430         

Glu Cys Leu Ala Ser Pro Arg Pro Ile Arg Asn Pro Tyr His Val Tyr 
        435                 440                 445             

Ser Asp Val Thr Thr Glu Ala Leu Ala Val Leu Asp Cys Val Arg Arg 
    450                 455                 460                 

Gly His Glu Thr Phe Gly Pro Arg Cys Val Gln Asp Tyr Leu Ile Ser 
465                 470                 475                 480 

Met Thr Gln Gly Ala Ser Asp Leu Leu Glu Val Leu Leu Leu Ala Lys 
                485                 490                 495     

Glu Ser Gly Leu Phe Gly Trp Pro Asp Gly Pro Met Ala Pro Pro Lys 
            500                 505                 510         

Ser Asp Leu Asn Val Val Pro Leu Phe Glu Thr Ile Glu Asp Leu Glu 
        515                 520                 525             

Ser Ala Ala Gly Ile Met Arg Ser Leu Phe Glu Asn Pro Val Tyr Arg 
    530                 535                 540                 

Arg His Leu Glu Met Arg Gly Trp Gln Gln Glu Ile Met Leu Gly Tyr 
545                 550                 555                 560 

Ser Asp Ser Asn Lys Asp Gly Gly Tyr Leu Thr Ala Asn Trp Ser Leu 
                565                 570                 575     

Tyr Met Ala Gln Lys His Leu Ile Arg Leu Ala Glu Ala Tyr Gly Val 
            580                 585                 590         

Arg Ile Lys Phe Phe His Gly Arg Gly Gly Ala Leu Gly Arg Gly Gly 
        595                 600                 605             

Gly Pro Val Glu Gln Ser Ile Leu Ala Gln Pro Thr Glu Ala Leu Arg 
    610                 615                 620                 

Gly His Val Lys Ile Thr Glu Gln Gly Glu Val Ile Ser Gln Arg Tyr 
625                 630                 635                 640 

Gly His Pro Gly Ile Ala Glu Arg Ser Leu Glu Ser Ser Ala Ala Ala 
                645                 650                 655     

Val Leu Val Gly Ala Thr Arg Glu Asp Ser Glu Glu Trp Ala Glu Arg 
            660                 665                 670         

His Pro Arg Trp Phe Arg Leu Leu Asp Arg Ala Ser Glu Ile Ser Phe 
        675                 680                 685             

Arg Ala Tyr Arg Lys Leu Val Phe Glu His Pro Ala Phe Leu Glu Tyr 
    690                 695                 700                 

Phe His Arg Ala Thr Pro Ile Asp Glu Ile Gly Lys Met Asn Ile Gly 
705                 710                 715                 720 

Ser Arg Pro Ser Arg Arg Ser Gln Ser Ala Arg Ile Glu Asp Leu Arg 
                725                 730                 735     

Ala Ile Pro Trp Val Phe Ser Trp Thr Gln Ser Arg His Leu Leu Pro 
            740                 745                 750         

Ala Trp Tyr Gly Phe Gly Ser Ala Ile Glu Ala Ile Met Arg Glu Asp 
        755                 760                 765             

Pro Arg Ala Leu Asp Asp Leu Arg Arg Met Tyr Glu Val Trp Pro Phe 
    770                 775                 780                 

Phe Arg Thr Leu Val Asp Asn Leu Gln Met Ala Leu Ala Lys Ala Asp 
785                 790                 795                 800 

Met Leu Val Ala Lys Glu Tyr Ala Gln Leu Ala Gly Glu Ala Gly Glu 
                805                 810                 815     

Ala Val Phe Pro Leu Ile Glu Glu Glu Tyr Ala Arg Thr Glu Arg Ala 
            820                 825                 830         

Val Leu Asp Ile Thr Gly Tyr Arg Gln Leu Leu Asp Asn Arg Pro Val 
        835                 840                 845             

Ile Arg Glu Ser Ile Ser Leu Arg Asn Pro Tyr Val Asp Pro Leu Ser 
    850                 855                 860                 

Phe Phe Gln Val Arg Leu Leu Ala Asp Leu Arg Thr Asp Asn Leu Ser 
865                 870                 875                 880 

Pro Glu Glu Arg Glu Ala Glu Leu Ala Asp Ala Leu Gln Thr Ile Asn 
                885                 890                 895     

Gly Ile Ala Ala Gly Leu Arg Asn Thr Gly 
            900                 905     

<210>   353
<211>   2721
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   353
ttggcgaacg acgcaccctt gcaccgggac atacgcgtcc tcggggattt gttgggagaa       60

gtgctggtcg agcagtgcgg ccggcgcgtc ttcgatcacg tcgaatccat tcgcctcgct      120

gccaaggcct ttcgcgcgga cccgtcgccc gaaacgcgcg cggcgctgca ggcggccgtg      180

tccgccgtgg agcccgagca ccggaacgac gtgattcacg cgttttcggt ctactttcag      240

ttggtcaacc tcgcggagca aaaccacagg cttcgccgcc accgagatta cgatcgctcg      300

caacaggtgc tgcgcgggtc gtttcgcgaa accatgcgca ccctggccga tcgcggcatg      360

accgccgacg acattgagtc cctgcttcgg gaggtcggga tcgagctcgt gctcaccgcg      420

catcccaccg aggcgctgcg ccgcaccgtg ctcgacaaac acacgaagat cgcggctttc      480

ctcgaggaca tggacgatcc gcgcaagacg ccgagagagc tcgacgtgct gcgcgagcga      540

attcgcaccg agatcgtcgc gctgtggcaa acgagatcgg tgcgcaagca gcgcatcacc      600

gtgctggatg aggtccgaaa cgggctgtac tttctggacc agatcctgtt cgacgtcctt      660

cctcgcgtgc atcaaaagct cgaacaggcg gtcgaggaac agtttggtcg tcagcttctc      720

gaactgcccc cgcttattcg cttcggctcg tggatggggg gcgatcgcga cggcaatccg      780

aacgtcacgt ccgacatcac ctggcagacg ctcgtcctcc actgcgatct cgccctcaac      840

aaatatgagc aaaagttgcg agaactcggg cgcgatctga gcgtgtccgt ggaccgggcg      900

ggcgcggacg aggatctcct ggcttccctg ggaggcgaaa acgacgagcc gtaccgggcg      960

ctcatcaacc ggatgctgga gcggctcgcc aacacgcggc gccggctgca cggggagcgg     1020

gtggacggtc ccgattacgc gtcacccgaa gcgatgatgg aggacgtcga acggatggcg     1080

agatcgctcg cgcatcaccg gggccagcgc atggtggatg cgtggttgcg cccgttcctg     1140

ctgcagcttc gcatcttcgg cttccacatg gtgacgctcg acatccgtca gcactccggc     1200

gttcatgagc aggcggtggc ggagctcttg cagacggcgg gcctcgtgga cgactacacg     1260

tcgcttggcg aggatgagcg cgtgcgcgtc ctgtccgaat gccttgcgtc gccgcgcccc     1320

attcgcaatc cgtatcacgt gtactccgat gtcaccacgg aggcgctcgc ggtcctcgac     1380

tgcgtgcggc gagggcacga gaccttcggg cctcgctgcg tgcaggacta cctcatttcc     1440

atgacgcaag gcgcgagcga cctgcttgag gtgttgctct tggcgaagga gtccggcttg     1500

ttcggctggc cggacgggcc gatggcgccg cccaagagcg acttgaacgt cgttccgctg     1560

tttgagacca tcgaggacct ggagtccgcg gcggggatca tgcggtcgct gtttgaaaac     1620

cccgtgtatc ggcgtcacct ggagatgcgc ggctggcagc aggagatcat gctcgggtat     1680

tccgacagca acaaggacgg cggctatctc accgccaact ggtcgctgta catggctcaa     1740

aagcacctga ttcgcctggc ggaagcgtac ggcgtgcgca tcaagttctt tcacggccgg     1800

ggcggcgcgc tggggcgagg gggcggtccc gtggagcaga gcattctcgc ccagcccacg     1860

gaggcgctcc gagggcacgt gaagatcacg gagcagggcg aggtcatctc gcagcggtat     1920

ggacacccgg gcatcgccga acgctcgctt gagtcctcgg cggcggctgt gctggtgggc     1980

gccacgcgag aggacagcga ggagtgggca gagcgccatc cgaggtggtt tcggcttttg     2040

gaccgagcgt cggaaatcag cttccgcgcc taccggaagc tggtcttcga gcatcccgcg     2100

ttcctcgagt atttccatcg ggcgacgccc attgacgaga tcggcaagat gaacattggg     2160

tcgaggcctt cgcggcgctc gcagtcggcg cgaatcgagg acctgcgggc catcccctgg     2220

gtgttctcgt ggacgcagag ccgccacctg ctgcccgcct ggtacggctt cggcagtgcg     2280

atagaggcca tcatgcggga ggaccctcgc gcgcttgaag accttcgccg catgtacgag     2340

gtgtggccgt tcttccggac gctggtcgac aatcttcaga tggcgctcgc caaggcggat     2400

atgctcgtgg cgaaggaata cgcgcagttg gcgggggagg cgggagaggc cgtctttccg     2460

ctgattgagg aggagtacgc gcgcacggag cgcgccgtgc tcgacatcac gggctaccgg     2520

cagcttctcg acaacaggcc ggtcatacgg gagtccatct cgcttcgcaa cccgtatgtc     2580

gatccgctgt cgttcttcca ggtgcgcctg ttggccgatc tgcgcacgga caacctgtcg     2640

cccgaagagc gcgaggcgga gctggccgac gcgctgcaga ccattaacgg catcgccgcg     2700

ggcctgcgca ataccggctg a                                               2721


<210>   354
<211>   2721
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   354
ttggcgaacg acgcaccctt gcaccgggac atacgcgtcc tcggggattt gttgggagaa       60

gtgctggtcg agcagtgcgg ccggcgcgtc ttcgatcacg tcgaatccat tcgcctcgct      120

gccaaggcct ttcgcgcgga cccgtcgccc gaaacgcgcg cggcgctgca ggcggccgtg      180

tccgccgtgg agcccgagca ccggaacgac gtgattcacg cgttttcggt ctactttcag      240

ttggtcaacc tcgcggagca aaaccacagg cttcgccgcc accgagatta cgatcgctcg      300

caacagattc tgcgcgggtc gtttcgcgaa accatgcgca ccctggccga tcgcggcatg      360

accgccgacg acattgagtc cctgcttcgg gaggtcggga tcgagctcgt gctcaccgcg      420

catcccaccg aggcgctgcg ccgcaccgtg ctcgacaaac acacgaagat cgcggctttc      480

ctcgaggaca tggacgatcc gcgcaagacg ccgagagagc tcgacgtgct gcgcgagcga      540

attcgcaccg agatcgtcgc gctgtggcaa acgagatcgg tgcgcaagca gcgcatcacc      600

gtgctggatg aggtccgaaa cgggctgtac tttctggacc agatcctgtt cgacgtcctt      660

cctcgcgtgc atcaaaagct cgaacaggcg gtcgaggaac agtttggtcg tcagcttctc      720

gaactgcccc cgcttattcg cttcggctcg tggatggggg gcgatcgcga cggcaatccg      780

aacgtcacgt ccgacatcac ctggcagacg ctcgtcctcc actgcgatct cgccctcaac      840

aaatatgagc aaaagttgcg agaactcggg cgcgatctga gcgtgtccgt ggaccgggcg      900

ggcgcggacg aggatctcct ggcttccctg ggaggcgaaa acgacgagcc gtaccgggcg      960

ctcatcaacc ggatgctgga gcggctcgcc aacacgcggc gccggctgca cggggagcgg     1020

gtggacggtc ccgattacgc gtcacccgaa gcgatgatgg aggacgtcga acggatggcg     1080

agatcgctcg cgcatcaccg gggccagcgc atggtggatg cgtggttgcg cccgttcctg     1140

ctgcagcttc gcatcttcgg cttccacatg gtgacgctcg acatccgtca gcactccggc     1200

gttcatgagc aggcggtggc ggagctcttg cagacggcgg gcctcgtgga cgactacacg     1260

tcgcttggcg aggaagagcg cgtgcgcgtc ctgtccgaat gccttgcgtc gccgcgcccc     1320

attcgcaatc cgtatcacgt gtactccgat gtcaccacgg aggcgctcgc ggtcctcgac     1380

tgcgtgcggc gagggcacga gaccttcggg cctcgctgcg tgcaggacta cctcatttcc     1440

atgacgcaag gcgcgagcga cctgcttgag gtgttgctct tggcgaagga gtccggcttg     1500

ttcggctggc cggacgggcc gatggcgccg cccaagagcg acttgaacgt cgttccgctg     1560

tttgagacca tcgaggacct ggagtccgcg gcggggatca tgcggtcgct gtttgaaaac     1620

cccgtgtatc ggcgtcacct ggagatgcgc ggctggcagc aggagatcat gctcgggtat     1680

tccgacagca acaaggacgg cggctatctc accgccaact ggtcgctgta catggctcaa     1740

aagcacctga ttcgcctggc ggaagcgtac ggcgtgcgca tcaagttctt tcacggccgg     1800

ggcggcgcgc tggggcgagg gggcggtccc gtggagcaga gcattctcgc ccagcccacg     1860

gaggcgctcc gagggcacgt gaagatcacg gagcagggcg aggtcatctc gcagcggtat     1920

ggacacccgg gcatcgccga acgctcgctt gagtcctcgg cggcggctgt gctggtgggc     1980

gccacgcgag aggacagcga ggagtgggca gagcgccatc cgaggtggtt tcggcttttg     2040

gaccgagcgt cggaaatcag cttccgcgcc taccggaagc tggtcttcga gcatcccgcg     2100

ttcctcgagt atttccatcg ggcgacgccc attgacgaga tcggcaagat gaacattggg     2160

tcgaggcctt cgcggcgctc gcagtcggcg cgaatcgagg acctgcgggc catcccctgg     2220

gtgttctcgt ggacgcagag ccgccacctg ctgcccgcct ggtacggctt cggcagtgcg     2280

atagaggcca tcatgcggga ggaccctcgc gcgcttgaag accttcgccg catgtacgag     2340

gtgtggccgt tcttccggac gctggtcgac aatcttcaga tggcgctcgc caaggcggat     2400

atgctcgtgg cgaaggaata cgcgcagttg gcgggggagg cgggagaggc cgtctttccg     2460

ctgattgagg aggagtacgc gcgcacggag cgcgccgtgc tcgacatcac gggctaccgg     2520

cagcttctcg acaacaggcc ggtcatacgg gagtccatct cgcttcgcaa cccgtatgtc     2580

gatccgctgt cgttcttcca ggtgcgcctg ttggccgatc tgcgcacgga caacctgtcg     2640

cccgaagagc gcgaggcgga gctggccgac gcgctgcaga ccattaacgg catcgccgcg     2700

ggcctgcgca ataccggctg a                                               2721


<210>   355
<211>   2721
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   355
ttggcgaacg acgcaccctt gcaccgggac atacgcgtcc tcggggattt gttgggagaa       60

gtgctggtcg agcagtgcgg caaacgcgtc ttcgatcacg tcgaatccat tcgcctcgct      120

gccaaggcct ttcgcgcgga cccgtcgccc gaaacgcgcg cggcgctgca ggcggccgtg      180

tccgccgtgg agcccgagca ccggaacgac gtgattcacg cgttttcggt ctactttcag      240

ttggtcaacc tcgcggagca aaaccacagg cttcgccgcc accgagatta cgatcgctcg      300

caacaggtgc tgcgcgggtc gtttcgcgaa accatgcgca ccctggccga tcgcggcatg      360

accgccgacg acattgagtc cctgcttcgg gaggtcggga tcgagctcgt gctcaccgcg      420

catcccaccg aggcgctgcg ccgcaccgtg ctcgacaaac acacgaagat cgcggctttc      480

ctcgaggaca tggacgatcc gcgcaagacg ccgagagagc tcgacgtgct gcgcgagcga      540

attcgcaccg agatcgtcgc gctgtggcaa acgagatcgg tgcgcaagca gcgcatcacc      600

gtgctggatg aggtccgaaa cgggctgtac tttctggacc agatcctgtt cgacgtcctt      660

cctcgcgtgc atcaaaagct cgaacaggcg gtcgaggaac agtttggtcg tcagcttctc      720

gaactgcccc cgcttattcg cttcggctcg tggatggggg gcgatcgcga cggcaatccg      780

aacgtcacgt ccgacatcac ctggcagacg ctcgtcctcc actgcgatct cgccctcaac      840

aaatatgagc aaaagttgcg agaactcggg cgcgatctga gcgtgtccgt ggaccgggcg      900

ggcgcggacg aggatctcct ggcttccctg ggaggcgaaa acgacgagcc gtaccgggcg      960

ctcatcaacc ggatgctgga gcggctcgcc aacacgcggc gccggctgca cggggagcgg     1020

gtggacggtc ccgattacgc gtcacccgaa gcgatgatgg aggacgtcga acggatggcg     1080

agatcgctcg cgcatcaccg gggccagcgc atggtggatg cgtggttgcg cccgttcctg     1140

ctgcagcttc gcatcttcgg cttccacatg gtgacgctcg acatccgtca gcactccggc     1200

gttcatgagc aggcggtggc ggagctcttg cagacggcgg gcctcgtgga cgactacacg     1260

tcgcttggcg aggaagagcg cgtgcgcgtc ctgtccgaat gccttgcgtc gccgcgcccc     1320

attcgcaatc cgtatcacgt gtactccgat gtcaccacgg aggcgctcgc ggtcctcgac     1380

tgcgtgcggc gagggcacga gaccttcggg cctcgctgcg tgcaggacta cctcatttcc     1440

atgacgcaag gcgcgagcga cctgcttgag gtgttgctct tggcgaagga gtccggcttg     1500

ttcggctggc cggacgggcc gatggcgccg cccaagagcg acttgaacgt cgttccgctg     1560

tttgagacca tcgaggacct ggagtccgcg gcggggatca tgcggtcgct gtttgaaaac     1620

cccgtgtatc ggcgtcacct ggagatgcgc ggctggcagc aggagatcat gctcgggtat     1680

tccgacagca acaaggacgg cggctatctc accgccaact ggtcgctgta catggctcaa     1740

aagcacctga ttcgcctggc ggaagcgtac ggcgtgcgca tcaagttctt tcacggccgg     1800

ggcggcgcgc tggggcgagg gggcggtccc gtggagcaga gcattctcgc ccagcccacg     1860

gaggcgctcc gagggcacgt gaagatcacg gagcagggcg aggtcatctc gcagcggtat     1920

ggacacccgg gcatcgccga acgctcgctt gagtcctcgg cggcggctgt gctggtgggc     1980

gccacgcgag aggacagcga ggagtgggca gagcgccatc cgaggtggtt tcggcttttg     2040

gaccgagcgt cggaaatcag cttccgcgcc taccggaagc tggtcttcga gcatcccgcg     2100

ttcctcgagt atttccatcg ggcgacgccc attgacgaga tcggcaagat gaacattggg     2160

tcgaggcctt cgcggcgctc gcagtcggcg cgaatcgagg acctgcgggc catcccctgg     2220

gtgttctcgt ggacgcagag ccgccacctg ctgcccgcct ggtacggctt cggcagtgcg     2280

atagaggcca tcatgcggga ggaccctcgc gcgcttgaag accttcgccg catgtacgag     2340

gtgtggccgt tcttccggac gctggtcgac aatcttcaga tggcgctcgc caaggcggat     2400

atgctcgtgg cgaaggaata cgcgcagttg gcgggggagg cgggagaggc cgtctttccg     2460

ctgattgagg aggagtacgc gcgcacggag cgcgccgtgc tcgacatcac gggctaccgg     2520

cagcttctcg acaacaggcc ggtcatacgg gagtccatct cgcttcgcaa cccgtatgtc     2580

gatccgctgt cgttcttcca ggtgcgcctg ttggccgatc tgcgcacgga caacctgtcg     2640

cccgaagagc gcgaggcgga gctggccgac gcgctgcaga ccattaacgg catcgccgcg     2700

ggcctgcgca ataccggctg a                                               2721


<210>   356
<211>   2721
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   356
ttggcgaacg acgcaccctt gcaccgggac atacgcgtcc tcggggattt gttgggagaa       60

gtgctggtcg agcagtgcgg ccggcgcgtc ttcgatcacg tcgaatccat tcgcctcgct      120

gccaaggcct ttcgcgcgga cccgtcgccc gaaacgcgcg cggcgctgca ggcggccgtg      180

tccgccgtgg agcccgagca ccggaacgac gtgattcacg cgttttcggt ctactttcag      240

ttggtcaacc tcgcggagca aaaccacagg cttcgccgcc accgagatta cgatcgctcg      300

caacaggtgc tgcgcgggtc gtttcgcgaa accatgcgca ccctggccga tcgcggcatg      360

accgccgacg acattgagtc cctgcttcgg gaggtcggga tcgagctcgt gctcaccgcg      420

catcccaccg aggcgctgcg ccgcaccgtg ctcgacaaac acacgaagat cgcggctttc      480

ctcgaggaca tggacgatcc gcgcaagacg ccgagagagc tcgacgtgct gcgcgagcga      540

attcgcaccg agatcgtcgc gctgtggcaa acgagatcgg tgcgcaagca gcgcatcacc      600

gtgctggatg aggtccgaaa cgggctgtac tttctggacc agatcctgtt cgacgtcctt      660

cctcgcgtgc atcaaaagct cgaacaggcg gtcgaggaac agtttggtcg tcagcttctc      720

gaactgcccc cgcttattcg cttcggctcg tggatggggg gcgatcgcga cggcaatccg      780

aacgtcacgt ccgacatcac ctggcagacg ctcgtcctcc actgcgatct cgccctcaac      840

aaatatgagc aaaagttgcg agatctcggg cgcgatctga gcgtgtccgt ggaccgggcg      900

ggcgcggacg aggatctcct ggcttccctg ggaggcgaaa acgacgagcc gtaccgggcg      960

ctcatcaacc ggatgctgga gcggctcgcc aacacgcggc gccggctgca cggggagcgg     1020

gtggacggtc ccgattacgc gtcacccgaa gcgatgatgg aggacgtcga acggatggcg     1080

agatcgctcg cgcatcaccg gggccagcgc atggtggatg cgtggttgcg cccgttcctg     1140

ctgcagcttc gcatcttcgg cttccacatg gtgacgctcg acatccgtca gcactccggc     1200

gttcatgagc aggcggtggc ggagctcttg cagacggcgg gcctcgtgga cgactacacg     1260

tcgcttggcg aggaagagcg cgtgcgcgtc ctgtccgaat gccttgcgtc gccgcgcccc     1320

attcgcaatc cgtatcacgt gtactccgat gtcaccacgg aggcgctcgc ggtcctcgac     1380

tgcgtgcggc gagggcacga gaccttcggg cctcgctgcg tgcaggacta cctcatttcc     1440

atgacgcaag gcgcgagcga cctgcttgag gtgttgctct tggcgaagga gtccggcttg     1500

ttcggctggc cggacgggcc gatggcgccg cccaagagcg acttgaacgt cgttccgctg     1560

tttgagacca tcgaggacct ggagtccgcg gcggggatca tgcggtcgct gtttgaaaac     1620

cccgtgtatc ggcgtcacct ggagatgcgc ggctggcagc aggagatcat gctcgggtat     1680

tccgacagca acaaggacgg cggctatctc accgccaact ggtcgctgta catggctcaa     1740

aagcacctga ttcgcctggc ggaagcgtac ggcgtgcgca tcaagttctt tcacggccgg     1800

ggcggcgcgc tggggcgagg gggcggtccc gtggagcaga gcattctcgc ccagcccacg     1860

gaggcgctcc gagggcacgt gaagatcacg gagcagggcg aggtcatctc gcagcggtat     1920

ggacacccgg gcatcgccga acgctcgctt gagtcctcgg cggcggctgt gctggtgggc     1980

gccacgcgag aggacagcga ggagtgggca gagcgccatc cgaggtggtt tcggcttttg     2040

gaccgagcgt cggaaatcag cttccgcgcc taccggaagc tggtcttcga gcatcccgcg     2100

ttcctcgagt atttccatcg ggcgacgccc attgacgaga tcggcaagat gaacattggg     2160

tcgaggcctt cgcggcgctc gcagtcggcg cgaatcgagg acctgcgggc catcccctgg     2220

gtgttctcgt ggacgcagag ccgccacctg ctgcccgcct ggtacggctt cggcagtgcg     2280

atagaggcca tcatgcggga ggaccctcgc gcgcttgaag accttcgccg catgtacgag     2340

gtgtggccgt tcttccggac gctggtcgac aatcttcaga tggcgctcgc caaggcggat     2400

atgctcgtgg cgaaggaata cgcgcagttg gcgggggagg cgggagaggc cgtctttccg     2460

ctgattgagg aggagtacgc gcgcacggag cgcgccgtgc tcgacatcac gggctaccgg     2520

cagcttctcg acaacaggcc ggtcatacgg gagtccatct cgcttcgcaa cccgtatgtc     2580

gatccgctgt cgttcttcca ggtgcgcctg ttggccgatc tgcgcacgga caacctgtcg     2640

cccgaagagc gcgaggcgga gctggccgac gcgctgcaga ccattaacgg catcgccgcg     2700

ggcctgcgca ataccggctg a                                               2721


<210>   357
<211>   2721
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   357
ttggcgaacg acgcaccctt gcaccgggac atacgcgtcc tcggggattt gttgggagaa       60

gtgctggtcg agcagtgcgg ccggcgcgtc ttcgatcacg tcgaatccat tcgcctcgct      120

gccaaggcct ttcgcgcgga cccgtcgccc gaaacgcgcg cggcgctgca ggcggccgtg      180

tccgccgtgg agcccgagca ccggaacgac gtgattcacg cgttttcggt ctactttcag      240

ttggtcaacc tcgcggagca aaaccacagg cttcgccgcc accgagatta cgatcgctcg      300

caacaggtgc tgcgcgggtc gtttcgcgaa accatgcgca ccctggccga tcgcggcatg      360

accgccgacg acattgagtc cctgcttcgg gaggtcggga tcgagctcgt gctcaccgcg      420

catcccaccg aggcgctgcg ccgcaccgtg ctcgacaaac acacgaagat cgcggctttc      480

ctcgaggaca tggacgatcc gcgcaagacg ccgagagagc tcgacgtgct gcgcgagcga      540

attcgcaccg agatcgtcgc gctgtggcaa acgagatcgg tgcgcaagca gcgcatcacc      600

gtgctggatg aggtccgaaa cgggctgtac tttctggacc agatcctgtt cgacgtcctt      660

cctcgcgtgc atcaaaagct cgaacaggcg gtcgaggaac agtttggtcg tcagcttctc      720

gaactgcccc cgcttattcg cttcggctcg tggatggggg gcgatcgcga cggcaatccg      780

aacgtcacgt ccgacatcac ctggcagacg ctcgtcctcc actgcgatct cgccctcaac      840

aaatatgagc aaaagttgcg agaactcggg cgcgatctga gcgtgtccgt ggaccgggcg      900

ggcgcggacg aggatctcct ggcttccctg ggaggcgaaa acgacgagcc gtaccgggcg      960

ctcatcaacc ggatgctgga gcggctcgcc aacacgcggc gccggctgca cggggagcgg     1020

gtggacggtc ccgattacgc gtcacccgaa gcgatgatgg aggacgtcga acggatggcg     1080

agatcgctcg cgcatcaccg gggccagcgc atggtggatg cgtggttgcg cccgttcctg     1140

ctgcagcttc gcatcttcgg cttccacatg gtgacgctcg acatccgtca gcactccggc     1200

gttcatgagc aggcggtggc ggagctcttg cagacggcgg gcctcgtgga cgactacacg     1260

tcgcttggcg aggaagagcg cgtgcgcgtc ctgtccgaat gccttgcgtc gccgcgcccc     1320

attcgcaatc cgtatcacgt gtactccgat gtcaccacgg aggcgctcgc ggtcctcgac     1380

tgcgtgcggc gagggcacga gaccttcggg cctcgctgcg tgcaggacta cctcatttcc     1440

atgacgcaag gcgcgagcga cctgcttgag gtgttgctct tggcgaagga gtccggcttg     1500

ttcggctggc cggacgggcc gatggcgccg cccaagagcg acttgaacgt cgttccgctg     1560

tttgagacca tcgaggacct ggagtccgcg gcggggatca tgcggtcgct gtttgaaaac     1620

cccgtgtatc ggcgtcacct ggagatgcgc ggctggcagc aggagatcat gctcgggtat     1680

tccgacagca acaaggacgg cggctatctc accgccaact ggtcgctgta catggctcaa     1740

aagcacctga ttcgcctggc ggaagcgtac ggcgtgcgca tcaagttctt tcacggccgg     1800

ggcggcgcgc tggggcgagg gggcggtccc gtggagcaga gcattctcgc ccagcccacg     1860

gaggcgctcc gagggcacgt gaagatcacg gagcagggcg aggtcatctc gcagcggtat     1920

ggacacccgg gcatcgccga acgctcgctt gagtcctcgg cggcggctgt gctggtgggc     1980

gccacgcgag aggacagcga ggagtgggca gagcgccatc cgaggtggtt tcggcttttg     2040

gaccgagcgt cggaaatcag cttccgcgcc taccggaagc tggtcttcga gcatcccgcg     2100

ttcctcgagt atttccatcg ggcgacgccc attgacgaga tcggcaagat gaacattggg     2160

tcgaggcctt cgcggcgctc gcagtcggcg cgaatcgagg acctgcgggc catcccctgg     2220

gtgttctcgt ggacgcagag ccgccacctg ctgcccgcct ggtacggctt cggcagtgcg     2280

atagaggcca tcatgcggga ggaccctcgc gcgcttgatg accttcgccg catgtacgag     2340

gtgtggccgt tcttccggac gctggtcgac aatcttcaga tggcgctcgc caaggcggat     2400

atgctcgtgg cgaaggaata cgcgcagttg gcgggggagg cgggagaggc cgtctttccg     2460

ctgattgagg aggagtacgc gcgcacggag cgcgccgtgc tcgacatcac gggctaccgg     2520

cagcttctcg acaacaggcc ggtcatacgg gagtccatct cgcttcgcaa cccgtatgtc     2580

gatccgctgt cgttcttcca ggtgcgcctg ttggccgatc tgcgcacgga caacctgtcg     2640

cccgaagagc gcgaggcgga gctggccgac gcgctgcaga ccattaacgg catcgccgcg     2700

ggcctgcgca ataccggctg a                                               2721


<210>   358
<211>   251
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   358
Met His His Gly Ala Ser Arg Leu Gly Arg Met Gly Val Arg Phe Met 
                5                   10                  15      

Arg Ser Asn Lys Val Tyr Glu Ser Ala Gly Ala Ala Ile Ala Asp Ile 
            20                  25                  30          

Pro Asn Gly Ala Thr Leu Leu Val Gly Gly Phe Gly Leu Cys Gly Ile 
        35                  40                  45              

Pro Met Ala Leu Ile Gln Ala Leu Arg Asp Arg Gly Val Ser Asp Leu 
    50                  55                  60                  

Val Cys Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly Ile 
65                  70                  75                  80  

Leu Leu Gln Thr Arg Gln Ile Arg Lys Met Val Ser Ser Tyr Val Gly 
                85                  90                  95      

Glu Asn Lys Thr Phe Glu Arg Gln Phe Leu Asn Gly Glu Leu Glu Val 
            100                 105                 110         

Glu Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly 
        115                 120                 125             

Ala Gly Ile Pro Ala Phe Tyr Thr Ala Thr Gly Val Gly Thr Ser Val 
    130                 135                 140                 

Ala Glu Gly Lys Glu Val Arg Thr Phe Asp Gly Arg Glu Tyr Val Leu 
145                 150                 155                 160 

Glu Arg Ala Ile Thr Gly Asp Phe Ala Leu Ile Lys Gly Trp Lys Ala 
                165                 170                 175     

Asp Lys Leu Gly Asn Val Ile Tyr His Glu Thr Glu Arg Asn Phe Asn 
            180                 185                 190         

Pro Val Met Ala Thr Ala Ala Lys Val Thr Ile Val Glu Val Glu Glu 
        195                 200                 205             

Leu Val Glu Pro Gly Glu Leu Asp Pro Asn Phe Ile His Thr Pro Ser 
    210                 215                 220                 

Ile Tyr Val His Arg Ile Val Val Asn Pro Asn Pro Ile Lys Arg Ile 
225                 230                 235                 240 

Glu Arg Arg Thr Val Arg Pro Arg Pro Gln Ala 
                245                 250     

<210>   359
<211>   756
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   359
atgcaccacg gcgcgtcgcg tcttggtcga atgggagtga ggtttatgcg ttccaacaag       60

gtgtacgagt cggcgggggc cgcaatcgcg gacattccca acggcgccac gctgctcgtc      120

ggcggcttcg ggctgtgcgg cattcccatg gcgctcatcc aggccctgcg agatcggggc      180

gtgtccgatc tggtctgcgt cagcaacaac tgcggcgtgg acgactgggg cctcgggatc      240

ttgcttcaga cgcggcagat ccgcaagatg gtctcctcgt acgtcgggga gaacaagacg      300

ttcgagcgcc agtttctgaa cggcgaactc gaggtggagt tggttcccca agggacgctg      360

gccgagcgca tccgcgccgg cggcgcgggc atcccggcgt tctacaccgc cacaggggtc      420

ggcacctccg tcgccgaggg caaggaagtg cggacgttcg acggacgcga gtacgtcctc      480

gaacgagcca tcactgggga ttttgcactc atcaagggtt ggaaggccga caagctcggc      540

aacgtcatct atcacgagac ggagcgcaac ttcaatccgg tcatggcgac ggccgccaag      600

gtcaccatcg tcgaggtgga ggagcttgtg gagccaggcg aattggatcc caacttcatt      660

catacgccaa gcatttacgt gcatcggatt gtcgtgaatc cgaaccccat caagcggatc      720

gagcggagaa ccgtccgccc gcgtccgcag gcttga                                756


<210>   360
<211>   231
<212>   PRT
<213>   Exiguobacterium sibiricum 255-15

<400>   360
Met Gln Gln Gly Lys Ile Tyr Asp Ser Phe Thr Glu Ala Thr Ala Asp 
                5                   10                  15      

Ile Phe Asp Gly Ala Thr Leu Val Val Gly Gly Phe Gly Leu Cys Gly 
            20                  25                  30          

Ile Pro Glu Lys Ser Ile Ala Ala Leu Gln Glu Gln Gly Val Lys Glu 
        35                  40                  45              

Leu Thr Val Val Ser Asn Asn Cys Gly Val Asp Asp Phe Gly Leu Gly 
    50                  55                  60                  

Ile Leu Leu Gln Ser Arg Gln Ile Lys Lys Met Val Ser Ser Tyr Val 
65                  70                  75                  80  

Gly Glu Asn Lys Thr Phe Glu Gln Gln Tyr Leu Ser Gly Glu Ile Glu 
                85                  90                  95      

Val Asp Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly 
            100                 105                 110         

Gly Ala Gly Ile Pro Gly Phe Tyr Thr Pro Thr Gly Val Gly Thr Pro 
        115                 120                 125             

Ile Ala Glu Gly Lys Glu Gln Lys Gln Phe Asp Gly Lys Thr Tyr Leu 
    130                 135                 140                 

Leu Glu Glu Gly Ile Val Gly Asp Phe Ala Leu Val Lys Ala Trp Lys 
145                 150                 155                 160 

Ala Asp Lys Leu Gly Asn Leu Val Phe Arg Lys Thr Ser Arg Asn Phe 
                165                 170                 175     

Asn Pro Leu Val Ala Thr Ala Gly Lys Val Thr Ile Ala Glu Val Glu 
            180                 185                 190         

Glu Leu Val Glu Val Gly Glu Leu Asp Pro Asn Glu Ile His Thr Pro 
        195                 200                 205             

Ala Val Tyr Val Gln Arg Ile Ile Val Gly Thr Asp Tyr Glu Lys Arg 
    210                 215                 220                 

Ile Glu Arg Arg Thr Val Arg 
225                 230     

<210>   361
<211>   227
<212>   PRT
<213>   Geobacter metallireducens GS-15

<400>   361
Lys Val Gln Ser Ser Ile Glu Lys Ala Leu Glu Gly Ile Gln Asp Gly 
                5                   10                  15      

Ala Thr Leu Met Val Gly Gly Phe Gly Leu Val Gly Ile Pro Glu Lys 
            20                  25                  30          

Leu Ile Leu Gly Leu Arg Glu Lys Gly Val Lys Asn Leu Thr Val Ile 
        35                  40                  45              

Ser Asn Asn Cys Gly Val Asp Asp Phe Gly Leu Gly Ile Leu Leu Gln 
    50                  55                  60                  

Asn Arg Gln Ile Arg Lys Met Val Ser Ser Tyr Val Gly Glu Asn Lys 
65                  70                  75                  80  

Glu Phe Glu Arg Gln Phe Leu Ser Gly Glu Leu Glu Val Glu Leu Thr 
                85                  90                  95      

Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly Ala Gly Ile 
            100                 105                 110         

Pro Ala Phe Tyr Thr Pro Ala Gly Val Gly Thr Pro Leu Ala Glu Gly 
        115                 120                 125             

Arg Glu Val Arg Ser Phe Asn Gly Arg Glu Tyr Leu Leu Glu Thr Gly 
    130                 135                 140                 

Leu Val Ala Asp Phe Ala Leu Val Lys Ala Trp Lys Gly Asp Trp Met 
145                 150                 155                 160 

Gly Asn Leu Ile Tyr Asn Lys Thr Ser Arg Asn Phe Asn Pro Met Met 
                165                 170                 175     

Ala Thr Ala Ala Lys Val Thr Ile Ala Glu Val Glu Asp Leu Leu Asp 
            180                 185                 190         

Pro Gly Glu Leu Asp Pro Ala Phe Ile His Thr Pro Gly Val Tyr Val 
        195                 200                 205             

Gln Arg Ile Val Leu Cys Gly Asn Tyr Glu Lys Arg Ile Glu Arg Arg 
    210                 215                 220                 

Thr Val Arg 
225         

<210>   362
<211>   230
<212>   PRT
<213>   Anaeromyxobacter sp. Fw109-5

<400>   362
Asn Lys Leu Val Glu Ser Ala Asp Ala Ala Val Ala Asp Ile Arg Asp 
                5                   10                  15      

Gly Ala Thr Val Met Val Gly Gly Phe Gly Leu Cys Gly Asn Pro Glu 
            20                  25                  30          

Asn Leu Ile Ala Ala Leu His Arg Lys Gly Val Lys Asp Leu Thr Val 
        35                  40                  45              

Ile Ser Asn Asn Cys Gly Thr Thr Glu Gln Gly Leu Gly Ile Leu Leu 
    50                  55                  60                  

Lys Ala Arg Gln Ile Arg Lys Met Val Ser Ser Tyr Val Gly Glu Asn 
65                  70                  75                  80  

Lys Glu Phe Glu Arg Gln Tyr Leu Ser Gly Glu Leu Glu Val Glu Leu 
                85                  90                  95      

Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly Ala Gly 
            100                 105                 110         

Ile Gly Gly Phe Tyr Thr Ala Thr Gly Val Gly Thr Gln Val Ala Glu 
        115                 120                 125             

Gly Lys Glu Thr Arg Val Ile Asp Gly Arg Glu Tyr Leu Leu Glu Arg 
    130                 135                 140                 

Pro Leu Val Ala Asp Phe Ala Leu Val Tyr Ala Trp Lys Ala Asp Thr 
145                 150                 155                 160 

Trp Gly Asn Leu Leu Tyr Arg Lys Thr Thr Arg Gln Phe Gly Pro Met 
                165                 170                 175     

Met Ala Thr Ala Ala Arg Ile Thr Ile Ala Glu Val Glu His Val Val 
            180                 185                 190         

Gln Pro Gly Glu Ile Asp Pro Asp Val Val His Thr Pro Ser Ile Tyr 
        195                 200                 205             

Val Lys Arg Leu Val Arg Gly Glu Arg Tyr Glu Lys Trp Ile Glu Arg 
    210                 215                 220                 

Arg Thr Val Arg Pro Arg 
225                 230 

<210>   363
<211>   231
<212>   PRT
<213>   Bacillus sp. B14905

<400>   363
Met Lys Asp Gly Lys Val Trp Gly Ser Phe Glu Glu Ala Val Ala Asp 
                5                   10                  15      

Ile Lys Asp Gly Asp Met Leu Ala Val Gly Gly Phe Gly Leu Cys Gly 
            20                  25                  30          

Ile Pro Glu Lys Ala Ile Ala Ala Leu Val Gln Lys Gly Thr Lys Asp 
        35                  40                  45              

Leu Thr Val Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly 
    50                  55                  60                  

Leu Leu Leu Ala Asn Lys Gln Ile Lys Lys Met Val Ala Ser Tyr Val 
65                  70                  75                  80  

Gly Glu Asn Lys Ile Phe Glu Gln Gln Phe Leu Ser Gly Glu Leu Glu 
                85                  90                  95      

Val Glu Leu Thr Pro Gln Gly Thr Leu Ala Glu Arg Leu Arg Ala Gly 
            100                 105                 110         

Gly Ala Gly Ile Pro Gly Phe Tyr Thr Ala Thr Gly Val Gly Thr Pro 
        115                 120                 125             

Ile Ala Glu Gly Lys Glu Val Lys Val Phe Asp Gly Lys Asp Tyr Ile 
    130                 135                 140                 

Leu Glu Lys Gly Ile Thr Ala Asp Phe Ala Leu Val Lys Ala Trp Lys 
145                 150                 155                 160 

Ala Asp Lys Leu Gly Asn Leu Val Tyr Arg Lys Thr Ser Arg Asn Phe 
                165                 170                 175     

Asn Pro Leu Ala Ala Met Ala Gly Lys Ile Thr Ile Ala Glu Val Glu 
            180                 185                 190         

Glu Ile Val Glu Ile Gly Glu Leu Asp Pro Asp His Ile His Thr Pro 
        195                 200                 205             

Gly Val Phe Val Gln Arg Val Leu Leu Gly Glu Asn Tyr Glu Lys Arg 
    210                 215                 220                 

Ile Glu Arg Leu Thr Val Lys 
225                 230     

<210>   364
<211>   227
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   364
Lys Val Leu Ser Ser Ser Lys Glu Ala Ala Lys Leu Ile His Asp Gly 
                5                   10                  15      

Asp Thr Leu Ile Ala Gly Gly Phe Gly Leu Cys Gly Ile Pro Glu Gln 
            20                  25                  30          

Leu Ile Leu Ser Ile Arg Asp Gln Gly Val Lys Asp Leu Thr Val Val 
        35                  40                  45              

Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly Leu Leu Leu Ala 
    50                  55                  60                  

Asn Lys Gln Ile Lys Lys Met Ile Ala Ser Tyr Val Gly Glu Asn Lys 
65                  70                  75                  80  

Ile Phe Glu Arg Gln Phe Leu Ser Gly Glu Leu Glu Val Glu Leu Val 
                85                  90                  95      

Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly Ala Gly Ile 
            100                 105                 110         

Pro Gly Phe Tyr Thr Ala Thr Gly Val Gly Thr Ser Ile Ala Glu Gly 
        115                 120                 125             

Lys Glu His Lys Thr Phe Gly Gly Arg Thr Tyr Val Leu Glu Arg Gly 
    130                 135                 140                 

Ile Thr Gly Asp Val Ala Ile Val Lys Ala Trp Lys Ala Asp Thr Met 
145                 150                 155                 160 

Gly Asn Leu Ile Phe Arg Lys Thr Ala Arg Asn Phe Asn Pro Ile Ala 
                165                 170                 175     

Ala Met Ala Gly Lys Ile Thr Ile Ala Glu Ala Glu Glu Ile Val Glu 
            180                 185                 190         

Ala Gly Glu Leu Asp Pro Asp His Ile His Thr Pro Gly Ile Tyr Val 
        195                 200                 205             

Gln His Val Val Leu Gly Ala Ser Gln Glu Lys Arg Ile Glu Lys Arg 
    210                 215                 220                 

Thr Val Gln 
225         

<210>   365
<211>   251
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   365
Met His His Gly Ala Ser Arg Leu Gly Arg Met Gly Val Arg Phe Met 
                5                   10                  15      

Arg Ser Asn Lys Val Tyr Glu Ser Ala Gly Ala Ala Ile Ala Asp Ile 
            20                  25                  30          

Pro Asn Gly Ala Thr Leu Leu Val Gly Gly Phe Gly Leu Cys Gly Ile 
        35                  40                  45              

Pro Met Ala Leu Ile Gln Ala Leu Arg Asp Arg Gly Val Ser Asp Leu 
    50                  55                  60                  

Val Cys Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly Ile 
65                  70                  75                  80  

Leu Leu Gln Thr Arg Gln Ile Arg Lys Met Val Ser Ser Tyr Val Gly 
                85                  90                  95      

Glu Asn Lys Thr Phe Glu Arg Gln Phe Leu Asn Gly Glu Leu Glu Val 
            100                 105                 110         

Glu Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly 
        115                 120                 125             

Ala Gly Ile Pro Ala Phe Tyr Thr Ala Thr Gly Val Gly Thr Ser Val 
    130                 135                 140                 

Ala Glu Gly Lys Glu Val Arg Thr Phe Asp Gly Arg Glu Tyr Val Leu 
145                 150                 155                 160 

Glu Arg Ala Ile Thr Gly Asp Phe Ala Leu Ile Lys Gly Trp Lys Ala 
                165                 170                 175     

Asp Lys Leu Gly Asn Val Ile Tyr His Glu Thr Glu Arg Asn Phe Asn 
            180                 185                 190         

Pro Val Met Ala Thr Ala Ala Lys Val Thr Ile Val Glu Val Glu Glu 
        195                 200                 205             

Leu Val Glu Pro Gly Glu Leu Asp Pro Asn Phe Ile His Thr Pro Ser 
    210                 215                 220                 

Ile Tyr Val His Arg Ile Val Val Asn Pro Asn Pro Leu Lys Arg Ile 
225                 230                 235                 240 

Glu Arg Arg Thr Val Arg Pro Arg Pro Gln Ala 
                245                 250     

<210>   366
<211>   251
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   366
Met His His Gly Ala Ser Arg Leu Gly Arg Met Gly Val Arg Phe Met 
                5                   10                  15      

Arg Ser Asn Lys Val Tyr Glu Ser Ala Gly Ala Ala Ile Ala Asp Ile 
            20                  25                  30          

Pro Asn Gly Ala Thr Leu Leu Val Gly Gly Phe Gly Leu Cys Gly Ile 
        35                  40                  45              

Pro Met Ala Leu Ile Gln Ala Leu Arg Asp Arg Gly Val Ser Asp Leu 
    50                  55                  60                  

Val Cys Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly Ile 
65                  70                  75                  80  

Leu Leu Gln Thr Arg Gln Ile Arg Lys Met Val Ser Ser Tyr Val Gly 
                85                  90                  95      

Glu Asn Lys Thr Phe Glu Arg Gln Phe Leu Asn Gly Glu Leu Glu Val 
            100                 105                 110         

Glu Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly 
        115                 120                 125             

Ala Gly Ile Pro Ala Phe Tyr Thr Ala Thr Gly Val Gly Thr Ser Val 
    130                 135                 140                 

Ala Glu Gly Lys Glu Val Arg Thr Phe Asp Gly Arg Glu Tyr Val Leu 
145                 150                 155                 160 

Glu Lys Ala Ile Thr Gly Asp Phe Ala Leu Ile Lys Gly Trp Lys Ala 
                165                 170                 175     

Asp Lys Leu Gly Asn Val Ile Tyr His Glu Thr Glu Arg Asn Phe Asn 
            180                 185                 190         

Pro Val Met Ala Thr Ala Ala Lys Val Thr Ile Val Glu Val Glu Glu 
        195                 200                 205             

Leu Val Glu Pro Gly Glu Leu Asp Pro Asn Phe Ile His Thr Pro Ser 
    210                 215                 220                 

Ile Tyr Val His Arg Ile Val Val Asn Pro Asn Pro Ile Lys Arg Ile 
225                 230                 235                 240 

Glu Arg Arg Thr Val Arg Pro Arg Pro Gln Ala 
                245                 250     

<210>   367
<211>   251
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   367
Met His His Gly Ala Ser Arg Leu Gly Arg Met Gly Val Arg Phe Met 
                5                   10                  15      

Arg Ser Asn Lys Val Tyr Glu Ser Ala Gly Ala Ala Ile Ala Asp Ile 
            20                  25                  30          

Pro Asn Gly Ala Thr Leu Leu Val Gly Gly Phe Gly Leu Cys Gly Ile 
        35                  40                  45              

Pro Met Ala Leu Ile Gln Ala Leu Arg Glu Arg Gly Val Ser Asp Leu 
    50                  55                  60                  

Val Cys Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly Ile 
65                  70                  75                  80  

Leu Leu Gln Thr Arg Gln Ile Arg Lys Met Val Ser Ser Tyr Val Gly 
                85                  90                  95      

Glu Asn Lys Thr Phe Glu Arg Gln Phe Leu Asn Gly Glu Leu Glu Val 
            100                 105                 110         

Glu Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly 
        115                 120                 125             

Ala Gly Ile Pro Ala Phe Tyr Thr Ala Thr Gly Val Gly Thr Ser Val 
    130                 135                 140                 

Ala Glu Gly Lys Glu Val Arg Thr Phe Asp Gly Arg Glu Tyr Val Leu 
145                 150                 155                 160 

Glu Arg Ala Ile Thr Gly Asp Phe Ala Leu Ile Lys Gly Trp Lys Ala 
                165                 170                 175     

Asp Lys Leu Gly Asn Val Ile Tyr His Glu Thr Glu Arg Asn Phe Asn 
            180                 185                 190         

Pro Val Met Ala Thr Ala Ala Lys Val Thr Ile Val Glu Val Glu Glu 
        195                 200                 205             

Leu Val Glu Pro Gly Glu Leu Asp Pro Asn Phe Ile His Thr Pro Ser 
    210                 215                 220                 

Ile Tyr Val His Arg Ile Val Val Asn Pro Asn Pro Ile Lys Arg Ile 
225                 230                 235                 240 

Glu Arg Arg Thr Val Arg Pro Arg Pro Gln Ala 
                245                 250     

<210>   368
<211>   251
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   368
Met His His Gly Ala Ser Arg Leu Gly Lys Met Gly Val Arg Phe Met 
                5                   10                  15      

Arg Ser Asn Lys Val Tyr Glu Ser Ala Gly Ala Ala Ile Ala Asp Ile 
            20                  25                  30          

Pro Asn Gly Ala Thr Leu Leu Val Gly Gly Phe Gly Leu Cys Gly Ile 
        35                  40                  45              

Pro Met Ala Leu Ile Gln Ala Leu Arg Asp Arg Gly Val Ser Asp Leu 
    50                  55                  60                  

Val Cys Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly Ile 
65                  70                  75                  80  

Leu Leu Gln Thr Arg Gln Ile Arg Lys Met Val Ser Ser Tyr Val Gly 
                85                  90                  95      

Glu Asn Lys Thr Phe Glu Arg Gln Phe Leu Asn Gly Glu Leu Glu Val 
            100                 105                 110         

Glu Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly 
        115                 120                 125             

Ala Gly Ile Pro Ala Phe Tyr Thr Ala Thr Gly Val Gly Thr Ser Val 
    130                 135                 140                 

Ala Glu Gly Lys Glu Val Arg Thr Phe Asp Gly Arg Glu Tyr Val Leu 
145                 150                 155                 160 

Glu Arg Ala Ile Thr Gly Asp Phe Ala Leu Ile Lys Gly Trp Lys Ala 
                165                 170                 175     

Asp Lys Leu Gly Asn Val Ile Tyr His Glu Thr Glu Arg Asn Phe Asn 
            180                 185                 190         

Pro Val Met Ala Thr Ala Ala Lys Val Thr Ile Val Glu Val Glu Glu 
        195                 200                 205             

Leu Val Glu Pro Gly Glu Leu Asp Pro Asn Phe Ile His Thr Pro Ser 
    210                 215                 220                 

Ile Tyr Val His Arg Ile Val Val Asn Pro Asn Pro Ile Lys Arg Ile 
225                 230                 235                 240 

Glu Arg Arg Thr Val Arg Pro Arg Pro Gln Ala 
                245                 250     

<210>   369
<211>   251
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   369
Met His His Gly Ala Ser Arg Leu Gly Arg Met Gly Val Arg Phe Met 
                5                   10                  15      

Arg Ser Asn Lys Val Tyr Glu Ser Ala Gly Ala Ala Ile Ala Asp Ile 
            20                  25                  30          

Pro Asn Gly Ala Thr Leu Leu Val Gly Gly Phe Gly Leu Cys Gly Ile 
        35                  40                  45              

Pro Met Ala Leu Ile Gln Ala Leu Arg Asp Arg Gly Val Ser Asp Leu 
    50                  55                  60                  

Val Cys Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly Ile 
65                  70                  75                  80  

Leu Leu Gln Thr Arg Gln Ile Arg Lys Met Val Ser Ser Tyr Val Gly 
                85                  90                  95      

Glu Asn Lys Thr Phe Glu Arg Gln Phe Leu Asn Gly Glu Leu Glu Val 
            100                 105                 110         

Glu Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly 
        115                 120                 125             

Ala Gly Ile Pro Ala Phe Tyr Thr Ala Thr Gly Val Gly Thr Ser Val 
    130                 135                 140                 

Ala Glu Gly Lys Glu Val Arg Thr Phe Asp Gly Arg Glu Tyr Val Leu 
145                 150                 155                 160 

Glu Arg Ala Ile Thr Gly Asp Phe Ala Leu Ile Lys Gly Trp Lys Ala 
                165                 170                 175     

Asp Arg Leu Gly Asn Val Ile Tyr His Glu Thr Glu Arg Asn Phe Asn 
            180                 185                 190         

Pro Val Met Ala Thr Ala Ala Lys Val Thr Ile Val Glu Val Glu Glu 
        195                 200                 205             

Leu Val Glu Pro Gly Glu Leu Asp Pro Asn Phe Ile His Thr Pro Ser 
    210                 215                 220                 

Ile Tyr Val His Arg Ile Val Val Asn Pro Asn Pro Ile Lys Arg Ile 
225                 230                 235                 240 

Glu Arg Arg Thr Val Arg Pro Arg Pro Gln Ala 
                245                 250     

<210>   370
<211>   756
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   370
atgcaccacg gcgcgtcgcg tcttggtcga atgggagtga ggtttatgcg ttccaacaag       60

gtgtacgagt cggcgggggc cgcaatcgcg gacattccca acggcgccac gctgctcgtc      120

ggcggcttcg ggctgtgcgg cattcccatg gcgctcatcc aggccctgcg agatcggggc      180

gtgtccgatc tggtctgcgt cagcaacaac tgcggcgtgg acgactgggg cctcgggatc      240

ttgcttcaga cgcggcagat ccgcaagatg gtctcctcgt acgtcgggga gaacaagacg      300

ttcgagcgcc agtttctgaa cggcgaactc gaggtggagt tggttcccca agggacgctg      360

gccgagcgca tccgcgccgg cggcgcgggc atcccggcgt tctacaccgc cacaggggtc      420

ggcacctccg tcgccgaggg caaggaagtg cggacgttcg acggacgcga gtacgtcctc      480

gaacgagcca tcactgggga ttttgcactc atcaagggtt ggaaggccga caagctcggc      540

aacgtcatct atcacgagac ggagcgcaac ttcaatccgg tcatggcgac ggccgccaag      600

gtcaccatcg tcgaggtgga ggagcttgtg gagccaggcg aattggatcc caacttcatt      660

catacgccaa gcatttacgt gcatcggatt gtcgtgaatc cgaacccctt aaagcggatc      720

gagcggagaa ccgtccgccc gcgtccgcag gcttga                                756


<210>   371
<211>   756
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   371
atgcaccacg gcgcgtcgcg tcttggtcga atgggagtga ggtttatgcg ttccaacaag       60

gtgtacgagt cggcgggggc cgcaatcgcg gacattccca acggcgccac gctgctcgtc      120

ggcggcttcg ggctgtgcgg cattcccatg gcgctcatcc aggccctgcg agatcggggc      180

gtgtccgatc tggtctgcgt cagcaacaac tgcggcgtgg acgactgggg cctcgggatc      240

ttgcttcaga cgcggcagat ccgcaagatg gtctcctcgt acgtcgggga gaacaagacg      300

ttcgagcgcc agtttctgaa cggcgaactc gaggtggagt tggttcccca agggacgctg      360

gccgagcgca tccgcgccgg cggcgcgggc atcccggcgt tctacaccgc cacaggggtc      420

ggcacctccg tcgccgaggg caaggaagtg cggacgttcg acggacgcga gtacgtcctc      480

gaaaaagcca tcactgggga ttttgcactc atcaagggtt ggaaggccga caagctcggc      540

aacgtcatct atcacgagac ggagcgcaac ttcaatccgg tcatggcgac ggccgccaag      600

gtcaccatcg tcgaggtgga ggagcttgtg gagccaggcg aattggatcc caacttcatt      660

catacgccaa gcatttacgt gcatcggatt gtcgtgaatc cgaaccccat caagcggatc      720

gagcggagaa ccgtccgccc gcgtccgcag gcttga                                756


<210>   372
<211>   756
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   372
atgcaccacg gcgcgtcgcg tcttggtcga atgggagtga ggtttatgcg ttccaacaag       60

gtgtacgagt cggcgggggc cgcaatcgcg gacattccca acggcgccac gctgctcgtc      120

ggcggcttcg ggctgtgcgg cattcccatg gcgctcatcc aggccctgcg agaacggggc      180

gtgtccgatc tggtctgcgt cagcaacaac tgcggcgtgg acgactgggg cctcgggatc      240

ttgcttcaga cgcggcagat ccgcaagatg gtctcctcgt acgtcgggga gaacaagacg      300

ttcgagcgcc agtttctgaa cggcgaactc gaggtggagt tggttcccca agggacgctg      360

gccgagcgca tccgcgccgg cggcgcgggc atcccggcgt tctacaccgc cacaggggtc      420

ggcacctccg tcgccgaggg caaggaagtg cggacgttcg acggacgcga gtacgtcctc      480

gaacgagcca tcactgggga ttttgcactc atcaagggtt ggaaggccga caagctcggc      540

aacgtcatct atcacgagac ggagcgcaac ttcaatccgg tcatggcgac ggccgccaag      600

gtcaccatcg tcgaggtgga ggagcttgtg gagccaggcg aattggatcc caacttcatt      660

catacgccaa gcatttacgt gcatcggatt gtcgtgaatc cgaaccccat caagcggatc      720

gagcggagaa ccgtccgccc gcgtccgcag gcttga                                756


<210>   373
<211>   756
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   373
atgcaccacg gcgcgtcgcg tcttggtaaa atgggagtga ggtttatgcg ttccaacaag       60

gtgtacgagt cggcgggggc cgcaatcgcg gacattccca acggcgccac gctgctcgtc      120

ggcggcttcg ggctgtgcgg cattcccatg gcgctcatcc aggccctgcg agatcggggc      180

gtgtccgatc tggtctgcgt cagcaacaac tgcggcgtgg acgactgggg cctcgggatc      240

ttgcttcaga cgcggcagat ccgcaagatg gtctcctcgt acgtcgggga gaacaagacg      300

ttcgagcgcc agtttctgaa cggcgaactc gaggtggagt tggttcccca agggacgctg      360

gccgagcgca tccgcgccgg cggcgcgggc atcccggcgt tctacaccgc cacaggggtc      420

ggcacctccg tcgccgaggg caaggaagtg cggacgttcg acggacgcga gtacgtcctc      480

gaacgagcca tcactgggga ttttgcactc atcaagggtt ggaaggccga caagctcggc      540

aacgtcatct atcacgagac ggagcgcaac ttcaatccgg tcatggcgac ggccgccaag      600

gtcaccatcg tcgaggtgga ggagcttgtg gagccaggcg aattggatcc caacttcatt      660

catacgccaa gcatttacgt gcatcggatt gtcgtgaatc cgaaccccat caagcggatc      720

gagcggagaa ccgtccgccc gcgtccgcag gcttga                                756


<210>   374
<211>   756
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   374
atgcaccacg gcgcgtcgcg tcttggtcga atgggagtga ggtttatgcg ttccaacaag       60

gtgtacgagt cggcgggggc cgcaatcgcg gacattccca acggcgccac gctgctcgtc      120

ggcggcttcg ggctgtgcgg cattcccatg gcgctcatcc aggccctgcg agatcggggc      180

gtgtccgatc tggtctgcgt cagcaacaac tgcggcgtgg acgactgggg cctcgggatc      240

ttgcttcaga cgcggcagat ccgcaagatg gtctcctcgt acgtcgggga gaacaagacg      300

ttcgagcgcc agtttctgaa cggcgaactc gaggtggagt tggttcccca agggacgctg      360

gccgagcgca tccgcgccgg cggcgcgggc atcccggcgt tctacaccgc cacaggggtc      420

ggcacctccg tcgccgaggg caaggaagtg cggacgttcg acggacgcga gtacgtcctc      480

gaacgagcca tcactgggga ttttgcactc atcaagggtt ggaaggccga ccgtctcggc      540

aacgtcatct atcacgagac ggagcgcaac ttcaatccgg tcatggcgac ggccgccaag      600

gtcaccatcg tcgaggtgga ggagcttgtg gagccaggcg aattggatcc caacttcatt      660

catacgccaa gcatttacgt gcatcggatt gtcgtgaatc cgaaccccat caagcggatc      720

gagcggagaa ccgtccgccc gcgtccgcag gcttga                                756


<210>   375
<211>   503
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   375
Met Phe Gln Ser Ala Trp Leu Met Arg Met Ala Glu Pro Trp Pro Glu 
                5                   10                  15      

Thr Gln Gly Glu Trp Asn Val Thr Leu Thr Arg Ala Gly Asn Val Arg 
            20                  25                  30          

Val Leu Phe Arg Val Arg Leu Glu Ala Gly Ala Ala Leu Gly Glu Val 
        35                  40                  45              

His Gly Ala Ile Val Arg Ala Gly Gly Glu Ile Val Ala Met Glu Thr 
    50                  55                  60                  

Arg Ala Leu His Ala Asp His Ser Val Arg Asp Ile Thr Val Ala Val 
65                  70                  75                  80  

Asp Thr Glu Pro Asp Val Arg Ala Val Glu Gln Ala Leu Asp Glu Val 
                85                  90                  95      

Gln Gly Val Lys Arg Leu Glu Thr Leu Asp Arg Thr Phe Leu Val His 
            100                 105                 110         

Val Gly Gly Lys Ile Ala Thr His Leu Lys Val Pro Val Val Asp Arg 
        115                 120                 125             

Asp Asp Leu Ala Val Val Tyr Thr Pro Gly Val Ala Arg Val Cys Glu 
    130                 135                 140                 

Ala Ile Arg Asp Arg Arg Asp Arg Ala Phe Glu Phe Thr Ile Arg Lys 
145                 150                 155                 160 

Asn Thr Val Ala Val Val Ser Asp Gly Ser Ala Val Leu Gly Leu Gly 
                165                 170                 175     

Asn Ile Gly Pro Glu Ala Ala Met Pro Val Met Glu Gly Lys Ala Met 
            180                 185                 190         

Leu Phe Lys Arg Phe Ala Asp Val Asp Ala Phe Pro Ile Cys Leu Ala 
        195                 200                 205             

Thr Gln Asp Val Asp Glu Ile Val Glu Thr Val Glu Arg Met Ala Pro 
    210                 215                 220                 

Ser Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe 
225                 230                 235                 240 

Glu Ile Glu Glu Arg Leu Arg Lys Arg Leu Asp Ile Pro Val Phe His 
                245                 250                 255     

Asp Asp Gln His Gly Thr Ala Val Val Met Leu Ala Gly Leu Ile Asn 
            260                 265                 270         

Ala Leu Lys Ile Val Asn Lys Arg Met Gln Asp Val Ser Val Val Val 
        275                 280                 285             

Ala Gly Val Gly Ala Ala Gly Val Ala Cys Thr Lys Ile Leu Leu Ala 
    290                 295                 300                 

Ala Gly Val Gly His Ile Val Gly Val Asp Arg Val Gly Ile Ile Glu 
305                 310                 315                 320 

Arg Gly Arg His Tyr Asp Asn Pro Val Lys Gln Trp Tyr Ala Glu Asn 
                325                 330                 335     

Thr Asn Ser Glu Asn Arg Arg Gly Thr Leu Glu Glu Ala Val Arg Gly 
            340                 345                 350         

Ala Asp Val Phe Ile Gly Val Ser Gly Pro Gly Ile Leu Thr Val Gly 
        355                 360                 365             

His Val Lys Gln Met Ala Arg Asp Pro Ile Val Phe Ala Met Ala Asn 
    370                 375                 380                 

Pro Ile Pro Glu Ile Leu Pro Glu Val Ala Ala Gly His Val Arg Val 
385                 390                 395                 400 

Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn Asn Val Leu 
                405                 410                 415     

Cys Phe Pro Gly Met Phe Arg Gly Ala Leu Asp Val Arg Ala Arg Asp 
            420                 425                 430         

Ile Thr Glu Glu Met Lys Gln Ala Ala Ala Leu Ala Ile Ala Glu Cys 
        435                 440                 445             

Val Pro Glu Glu Gln Leu Ser Glu Gln Tyr Ile Ile Pro Ser Pro Phe 
    450                 455                 460                 

Asp Pro Asn Val Val Pro Ala Val Ser Arg Ala Val Gln Ala Ala Ala 
465                 470                 475                 480 

Val Arg Ser Gly Val Ala Arg Ala Ala Ala Pro Leu Glu Leu Glu Glu 
                485                 490                 495     

Glu Pro Leu Tyr Thr Glu Met 
            500             

<210>   376
<211>   1512
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   376
gtgtttcaat ccgcctggct gatgcggatg gcggagccgt ggcccgaaac tcagggggag       60

tggaacgtga cactgacgcg tgccggcaat gttcgagttc tgtttcgcgt tcgcttggag      120

gcgggcgcgg cgcttgggga ggtgcatggc gccattgtgc gcgccggagg cgagatcgtc      180

gccatggaga cccgcgcgct gcatgcggat cacagcgtgc gcgacatcac cgtcgcggtc      240

gataccgagc ccgatgtccg ggctgtcgag caagcgctgg acgaggtaca gggcgtgaaa      300

cgcctggaga cgctggaccg cacatttctg gtccacgtgg ggggcaaaat cgccacacac      360

ctgaaggtgc ccgtggtcga tcgcgacgac ctggccgttg tgtacacgcc gggcgtggcg      420

cgcgtgtgcg aggccattcg ggatcgccgc gatcgcgcct tcgaattcac catccgcaag      480

aacacggtgg cggtggtgag cgacggctcg gccgtgctag ggctggggaa cattggcccg      540

gaggccgcca tgccggtcat ggaagggaag gcgatgctgt tcaagcgctt cgccgacgtg      600

gatgccttcc ccatctgctt ggccacgcag gacgtggacg agattgtcga aaccgtcgag      660

cgaatggcgc cgtcgttcgg cgggatcaac ctcgaggaca tctcgtcgcc gcggtgtttc      720

gagatcgagg agcggctgcg gaaacggctc gacattccgg tgtttcacga cgatcagcac      780

ggcacagcgg tcgtcatgct ggccgggctc atcaatgcac tgaagattgt gaacaagcgg      840

atgcaggatg tgtccgtcgt cgtggcgggg gtcggcgcgg caggcgtggc gtgcaccaag      900

atcctgctcg cggccggtgt ggggcatatc gtcggcgtgg atcgcgtagg catcatcgag      960

cgcggccgcc actatgacaa ccccgtgaag cagtggtacg cggagaacac gaactccgag     1020

aatcggcgcg ggaccctcga agaagcggtg cgcggcgccg acgtgttcat cggcgtctcc     1080

ggcccgggca tcctgaccgt cggtcacgtc aagcaaatgg cgcgcgatcc cattgtgttt     1140

gccatggcga atcccatccc ggaaatcctg cccgaggtgg cggcgggcca cgtgcgcgtg     1200

atggcgaccg gacgatccga ctacccgaat cagattaaca acgtgctctg ttttcccggc     1260

atgttccgcg gggcgctcga cgtccgcgcg cgggatatca cggaagagat gaaacaggcc     1320

gcggcgctcg ccatcgccga gtgcgtgccg gaagagcaac tgtcggagca gtacatcatc     1380

ccgagcccgt tcgatccgaa cgtcgtcccg gccgtgagcc gcgcggtgca agcagccgcg     1440

gttcggtccg gcgtggcgcg ggcggcagct cccctcgagc tcgaggaaga gcccctctac     1500

accgagatgt ag                                                         1512


<210>   377
<211>   436
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   377
Met Asn Ile Thr Ile Arg Leu Gln Phe Glu Lys Asp Ile Val Ser Phe 
                5                   10                  15      

Ser Asp Ile Ala Ala Ala Ile Gly Lys Ala Gly Gly Asp Ile Val Gly 
            20                  25                  30          

Ile Asp Val Ile Ser Ser Ser Lys Val His Thr Val Arg Asp Ile Thr 
        35                  40                  45              

Val Ser Ala Leu Asp Thr Lys Gln Cys Asp Leu Ile Ile Glu Ala Leu 
    50                  55                  60                  

Lys Lys Ile Gln Gly Val Lys Ile Ile Asn Val Ser Asp Arg Thr Phe 
65                  70                  75                  80  

Leu Met His Ile Gly Gly Lys Ile Glu Thr Asn Ser Lys Ile Pro Val 
                85                  90                  95      

Lys Thr Arg Asp Asp Leu Ser Arg Val Tyr Thr Pro Gly Val Ala Arg 
            100                 105                 110         

Val Cys Thr Ala Ile Ala Glu Asp Pro Arg Lys Ala Tyr Ser Leu Thr 
        115                 120                 125             

Ile Lys Arg Asn Thr Val Ala Val Val Ser Asp Gly Thr Ala Val Leu 
    130                 135                 140                 

Gly Leu Gly Asp Ile Gly Pro Tyr Ala Ala Met Pro Val Met Glu Gly 
145                 150                 155                 160 

Lys Ala Met Leu Phe Lys Glu Phe Ala Gly Val Asp Ala Phe Pro Ile 
                165                 170                 175     

Cys Leu Asn Thr Lys Asp Thr Glu Glu Ile Ile Gln Ile Val Lys Ala 
            180                 185                 190         

Ile Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ala Pro 
        195                 200                 205             

Arg Cys Phe Glu Ile Glu Lys Arg Leu Lys Glu Glu Leu Asp Ile Pro 
    210                 215                 220                 

Val Phe His Asp Asp Gln His Gly Thr Ala Val Val Leu Leu Ala Gly 
225                 230                 235                 240 

Leu Leu Asn Ala Leu Lys Ile Val Asp Lys Lys Leu Glu Asp Ile Lys 
                245                 250                 255     

Val Val Leu Thr Gly Ile Gly Ala Ala Gly Ile Ala Cys Thr Lys Ile 
            260                 265                 270         

Leu Leu Ala Ala Gly Val Arg Asn Ile Ile Gly Val Asp Arg His Gly 
        275                 280                 285             

Ala Ile His Arg Asp Glu Thr Tyr Glu Asn Pro Tyr Trp Gln Glu Tyr 
    290                 295                 300                 

Ala Gln Ile Thr Asn Pro Asp Asn Leu Lys Gly Ser Leu Ser Asp Val 
305                 310                 315                 320 

Ile Ala Gly Ala Asp Val Phe Ile Gly Val Ser Ala Pro Gly Ile Leu 
                325                 330                 335     

Lys Val Glu Asp Val Lys Lys Met Ala Arg Asp Pro Ile Val Phe Ala 
            340                 345                 350         

Met Ala Asn Pro Ile Pro Glu Ile Asp Pro Glu Leu Ala Glu Pro Tyr 
        355                 360                 365             

Val Arg Val Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn 
    370                 375                 380                 

Asn Val Leu Cys Phe Pro Gly Ile Phe Arg Gly Ala Leu Asp Cys Arg 
385                 390                 395                 400 

Ala Arg Glu Ile Asn Glu Glu Met Lys Leu Ala Ala Ala Lys Ala Ile 
                405                 410                 415     

Ala Ser Val Val Thr Glu Asp Glu Leu Asn Glu Thr Tyr Ile Ile Pro 
            420                 425                 430         

Ser Val Phe Asn 
        435     

<210>   378
<211>   436
<212>   PRT
<213>   NAD-dependent malic enzyme (NAD-ME) gb|AAA22585.1| malic enzyme (EC 1.1.1.38) Score: 525 Significance: 1e-147 Identities: 268/436 Positives: 336/436 Gaps: 1/436

<400>   378
Met Asn Ile Thr Ile Arg Leu Gln Phe Glu Lys Asp Ile Val Ser Phe 
                5                   10                  15      

Ser Asp Ile Ala Ala Ala Ile Gly Lys Ala Gly Gly Asp Ile Val Gly 
            20                  25                  30          

Ile Asp Val Ile Ser Ser Ser Lys Val His Thr Val Arg Asp Ile Thr 
        35                  40                  45              

Val Ser Ala Leu Asp Thr Lys Gln Cys Asp Leu Ile Ile Glu Ala Leu 
    50                  55                  60                  

Lys Lys Ile Arg Gly Val Lys Ile Val Asn Val Ser Asp Arg Thr Phe 
65                  70                  75                  80  

Leu Met His Ile Gly Gly Lys Ile Glu Thr Asn Ser Lys Ile Pro Val 
                85                  90                  95      

Lys Thr Arg Asp Asp Leu Ser Arg Val Tyr Thr Pro Gly Val Ala Arg 
            100                 105                 110         

Val Cys Thr Ala Ile Ala Glu Asp Pro Arg Lys Ala Tyr Ser Leu Thr 
        115                 120                 125             

Ile Lys Arg Asn Thr Val Ala Val Val Ser Asp Gly Thr Ala Val Leu 
    130                 135                 140                 

Gly Leu Gly Asp Ile Gly Pro Tyr Ala Ala Met Pro Val Met Glu Gly 
145                 150                 155                 160 

Lys Ala Met Leu Phe Lys Glu Phe Ala Gly Val Asp Ala Phe Pro Ile 
                165                 170                 175     

Cys Leu Asp Thr Lys Asp Thr Glu Glu Ile Ile Gln Ile Val Lys Ala 
            180                 185                 190         

Ile Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ala Pro 
        195                 200                 205             

Arg Cys Phe Glu Ile Glu Lys Arg Leu Lys Glu Glu Leu Asp Ile Pro 
    210                 215                 220                 

Val Phe His Asp Asp Gln His Gly Thr Ala Val Val Leu Leu Ala Gly 
225                 230                 235                 240 

Leu Leu Asn Ala Leu Lys Ile Val Asp Lys Lys Leu Glu Asp Ile Lys 
                245                 250                 255     

Val Val Leu Thr Gly Ile Gly Ala Ala Gly Ile Ala Cys Thr Lys Ile 
            260                 265                 270         

Leu Leu Ala Ala Gly Val Arg Asn Ile Ile Gly Val Asp Arg His Gly 
        275                 280                 285             

Ala Ile His Arg Asp Glu Thr Tyr Glu Asn Pro Tyr Trp Gln Glu Tyr 
    290                 295                 300                 

Ala Gln Leu Thr Asn Pro Asp Asn Leu Lys Gly Ser Leu Ser Asp Val 
305                 310                 315                 320 

Ile Ala Gly Ala Asp Val Phe Ile Gly Val Ser Ala Pro Gly Ile Leu 
                325                 330                 335     

Lys Val Glu Asp Val Lys Lys Met Ala Arg Asp Pro Ile Val Phe Ala 
            340                 345                 350         

Met Ala Asn Pro Ile Pro Glu Ile Asp Pro Glu Leu Ala Glu Pro Tyr 
        355                 360                 365             

Val Arg Val Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn 
    370                 375                 380                 

Asn Val Leu Cys Phe Pro Gly Ile Phe Arg Gly Ala Leu Asp Cys Arg 
385                 390                 395                 400 

Ala Arg Glu Ile Asn Glu Glu Met Lys Leu Ala Ala Ala Lys Ala Ile 
                405                 410                 415     

Ala Ser Val Val Thr Glu Asp Glu Leu Asn Glu Thr Tyr Ile Ile Pro 
            420                 425                 430         

Ser Val Phe Asn 
        435     

<210>   379
<211>   422
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   379
Ala Leu Gly Arg Ile Leu Thr Thr Ile Gly Asp Ala Gly Gly Met Val 
                5                   10                  15      

Gly Ala Ile Asp Ile Val Arg Met Gly Gln Glu Arg Ser Ile Arg Asp 
            20                  25                  30          

Ile Thr Val Asn Ala Arg Asp Ser Glu His Gly Gln Arg Ile Val Arg 
        35                  40                  45              

Ala Val Gly Ala Leu Pro Glu Val Arg Val Val Asn Val Ser Asp Arg 
    50                  55                  60                  

Thr Phe Leu Leu His Leu Gly Gly Lys Ile Glu Val His Ser Lys Ile 
65                  70                  75                  80  

Pro Val Arg Thr Arg Asp Asp Leu Ser Met Ala Tyr Thr Pro Gly Val 
                85                  90                  95      

Ala Arg Val Cys Arg Ala Ile Ala Gln Glu Pro Glu Arg Ala Phe Asn 
            100                 105                 110         

Leu Thr Ile Lys Arg Asn Ser Val Ala Val Val Thr Asp Gly Thr Ala 
        115                 120                 125             

Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala Ala Met Pro Val Met 
    130                 135                 140                 

Glu Gly Lys Ala Met Leu Phe Lys Glu Phe Ala Gly Val Asp Ala Phe 
145                 150                 155                 160 

Pro Val Cys Leu Asp Thr Lys Asp Pro Glu Glu Ile Val Arg Thr Val 
                165                 170                 175     

Lys Tyr Val Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser 
            180                 185                 190         

Ala Pro Arg Cys Phe Glu Ile Glu Glu Arg Leu Lys Gln Glu Leu Asp 
        195                 200                 205             

Ile Pro Val Phe His Asp Asp Gln His Gly Thr Ala Val Val Val Leu 
    210                 215                 220                 

Ala Ala Leu Ile Asn Ala Leu Arg Ile Val Gly Lys Arg Met Glu Glu 
225                 230                 235                 240 

Leu Lys Val Val Val Cys Gly Val Gly Ala Ala Gly Val Ala Cys Ala 
                245                 250                 255     

Lys Ile Leu Leu Ala Ala Gly Val Lys Asn Ile Val Gly Cys Asp Arg 
            260                 265                 270         

Tyr Gly Val Val Tyr Arg Gly Arg Gly Asp Ala Asp Thr Ser Arg Gly 
        275                 280                 285             

Trp Phe Ala Glu Asn Thr Asn Pro Glu Asn Ile Arg Gly Thr Leu Ala 
    290                 295                 300                 

Asp Ala Ile Arg Gly Ala Asp Val Phe Ile Gly Val Ser Ala Pro Asp 
305                 310                 315                 320 

Val Leu Thr Val Glu His Ile Glu Ser Met Ala Asp Glu Pro Ile Val 
                325                 330                 335     

Phe Ala Met Ala Asn Pro Asp Pro Glu Ile Arg Pro Glu Ile Ala Tyr 
            340                 345                 350         

Gly His Ala Arg Ile Ile Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln 
        355                 360                 365             

Ile Asn Asn Val Leu Cys Phe Pro Gly Val Phe Arg Gly Ala Leu Asp 
    370                 375                 380                 

Ile Arg Ala Arg Glu Ile Asn Glu Glu Met Lys Leu Ala Ala Ala Arg 
385                 390                 395                 400 

Ala Ile Ala Gly Val Ile Pro Glu Glu Ser Leu Ser Glu Asp Tyr Ile 
                405                 410                 415     

Ile Pro Ser Val Phe Asp 
            420         

<210>   380
<211>   440
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   380
Arg Leu Ala Ser Met Arg Ile Ile Val Arg Leu Glu Ile Glu Asn Thr 
                5                   10                  15      

Gly Ser Ile Phe Ser Tyr Ile Ala Thr Ala Ile Gly Ala Ser Gly Gly 
            20                  25                  30          

Asp Ile Val Ala Val Asp Leu Ile Gln Ser Arg Arg Asp Val Val Val 
        35                  40                  45              

Arg Asp Ile Thr Ile Ala Val Glu Asn Arg Ala His Gly Asp Arg Ile 
    50                  55                  60                  

Val Gln Ala Leu Ala Ala Leu Pro Gly Val Lys Val Val Asn Val Ser 
65                  70                  75                  80  

Asp Arg Ile Phe Leu Ala His Leu Gly Gly Lys Ile Glu Val Lys Pro 
                85                  90                  95      

Arg Val Gln Val Lys Thr Arg Asp Asp Leu Ser Val Val Tyr Thr Pro 
            100                 105                 110         

Gly Val Ala Asp Val Cys Arg Ala Ile Ala Glu Asp Pro Ala Lys Ala 
        115                 120                 125             

Phe Thr Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val Thr Asp Gly 
    130                 135                 140                 

Thr Ala Val Leu Gly Leu Gly Asn Ile Gly Pro Ala Ala Ala Leu Pro 
145                 150                 155                 160 

Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala Gly Val Asp 
                165                 170                 175     

Ala Phe Pro Ile Cys Leu Asp Thr Thr Asp Pro Asp Glu Ile Val Arg 
            180                 185                 190         

Ile Val Lys Ala Ile Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu Asp 
        195                 200                 205             

Ile Ser Ser Pro Arg Cys Phe Glu Ile Glu Glu Arg Leu Lys Glu Glu 
    210                 215                 220                 

Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr Ala Val Val 
225                 230                 235                 240 

Val Leu Ala Gly Leu Met Asn Ala Ala Arg Val Val Gly Lys Glu Leu 
                245                 250                 255     

Ala Asp Leu Arg Val Val Val Cys Gly Ile Gly Ala Ala Gly Val Ala 
            260                 265                 270         

Ile Ser Lys Met Leu Met Ala Ala Gly Ile Thr Asn Ile Val Gly Val 
        275                 280                 285             

Asp Arg Val Gly Ile Ile Glu Arg Gly Lys Thr Tyr Glu Asn Pro Met 
    290                 295                 300                 

Trp Gln Trp Tyr Ala Glu His Thr Asn Pro Glu Asn Arg His Gly Thr 
305                 310                 315                 320 

Leu Asp Asp Ala Ile Glu Gly Ala Asp Ala Phe Ile Gly Val Ser Ala 
                325                 330                 335     

Pro Asn Val Leu Lys Val Glu His Val Lys Lys Met Ala Lys Asp Pro 
            340                 345                 350         

Ile Val Phe Ala Met Ala Asn Pro Val Pro Glu Ile Asp Pro Asp Glu 
        355                 360                 365             

Ala Ala Pro Tyr Val Ala Val Met Ala Thr Gly Arg Ser Asp Tyr Pro 
    370                 375                 380                 

Asn Gln Val Asn Asn Leu Leu Cys Phe Pro Gly Ile Phe Arg Gly Ala 
385                 390                 395                 400 

Leu Asn Cys Arg Ala Arg Gln Ile Asn Glu Ala Met Lys Leu Ala Ala 
                405                 410                 415     

Ala Arg Ala Ile Ala Ser Val Val Ser Asp Glu Glu Leu His Ala Glu 
            420                 425                 430         

Tyr Ile Ile Pro Ser Val Phe Asn 
        435                 440 

<210>   381
<211>   393
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   381
Met Arg Asp Ile Thr Val Ser Ala Leu Asp Thr Lys Gln Cys Asp Leu 
                5                   10                  15      

Ile Ile Glu Ala Leu Lys Lys Ile Arg Gly Val Lys Ile Val Asn Val 
            20                  25                  30          

Ser Asp Arg Thr Phe Leu Met His Ile Gly Gly Lys Ile Glu Thr Asn 
        35                  40                  45              

Ser Lys Ile Pro Val Lys Thr Arg Asp Asp Leu Ser Arg Val Tyr Thr 
    50                  55                  60                  

Pro Gly Val Ala Arg Val Cys Thr Ala Ile Ala Glu Asp Pro Arg Lys 
65                  70                  75                  80  

Ala Tyr Ser Leu Thr Ile Lys Arg Asn Thr Val Ala Val Val Ser Asp 
                85                  90                  95      

Gly Thr Ala Val Leu Gly Leu Gly Asp Ile Gly Pro Tyr Ala Ala Met 
            100                 105                 110         

Pro Val Met Glu Gly Lys Ala Met Leu Phe Lys Gln Phe Ala Gly Val 
        115                 120                 125             

Asp Ala Phe Pro Val Cys Leu Asp Thr Lys Asp Thr Glu Glu Ile Ile 
    130                 135                 140                 

Gln Ile Val Lys Ala Ile Ala Pro Ala Phe Gly Gly Ile Asn Leu Glu 
145                 150                 155                 160 

Asp Ile Ser Ala Pro Arg Cys Phe Glu Ile Glu Ala Arg Leu Lys Glu 
                165                 170                 175     

Glu Leu Asp Ile Pro Val Phe His Asp Asp Gln His Gly Thr Ala Val 
            180                 185                 190         

Val Leu Leu Ala Gly Leu Leu Asn Ala Leu Lys Ile Val Asp Lys Lys 
        195                 200                 205             

Leu Glu Asp Ile Lys Val Val Leu Thr Gly Ile Gly Ala Ala Gly Ile 
    210                 215                 220                 

Ala Cys Thr Lys Ile Leu Leu Ala Ala Gly Val Arg Asn Ile Ile Gly 
225                 230                 235                 240 

Val Asp Arg Tyr Gly Ala Ile His Arg Asp Glu Thr Tyr Glu Asn Pro 
                245                 250                 255     

Tyr Trp Gln Glu Tyr Ala Gln Ile Thr Asn Pro Tyr Asn Leu Lys Gly 
            260                 265                 270         

Ser Leu Ser Asp Val Ile Val Gly Ala Asp Val Phe Ile Gly Val Ser 
        275                 280                 285             

Ala Pro Gly Ile Leu Lys Val Glu Asp Val Lys Lys Met Ala Arg Asp 
    290                 295                 300                 

Pro Ile Val Phe Ala Met Ala Asn Pro Val Pro Glu Ile Asp Pro Glu 
305                 310                 315                 320 

Leu Ala Glu Pro Tyr Val Arg Val Met Ala Thr Gly Arg Ser Asp Tyr 
                325                 330                 335     

Pro Asn Gln Ile Asn Asn Val Leu Cys Phe Pro Gly Ile Phe Arg Gly 
            340                 345                 350         

Ala Leu Asp Cys Arg Ala Lys Glu Ile Asn Glu Glu Met Lys Leu Ala 
        355                 360                 365             

Ala Ala Lys Ala Ile Ala Ser Val Val Thr Glu Asp Glu Leu Asn Glu 
    370                 375                 380                 

Thr Tyr Ile Ile Pro Ser Val Phe Asn 
385                 390             

<210>   382
<211>   503
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   382
Met Phe Gln Ser Ala Trp Leu Met Arg Met Ala Glu Pro Trp Pro Glu 
                5                   10                  15      

Thr Gln Gly Glu Trp Asn Val Thr Leu Thr Arg Ala Gly Asn Val Arg 
            20                  25                  30          

Val Leu Phe Arg Val Arg Leu Glu Ala Gly Ala Ala Leu Gly Glu Val 
        35                  40                  45              

His Gly Ala Ile Val Arg Ala Gly Gly Glu Ile Val Ala Met Glu Thr 
    50                  55                  60                  

Arg Ala Leu His Ala Asp His Ser Val Arg Asp Ile Thr Val Ala Val 
65                  70                  75                  80  

Asp Thr Glu Pro Asp Val Arg Ala Val Glu Gln Ala Leu Asp Glu Val 
                85                  90                  95      

Gln Gly Val Lys Arg Leu Glu Thr Leu Asp Arg Thr Phe Leu Val His 
            100                 105                 110         

Val Gly Gly Lys Ile Ala Thr His Leu Lys Val Pro Val Val Asp Arg 
        115                 120                 125             

Asp Asp Leu Ala Val Val Tyr Thr Pro Gly Val Ala Arg Val Cys Glu 
    130                 135                 140                 

Ala Ile Arg Asp Arg Arg Asp Arg Ala Phe Glu Phe Thr Ile Arg Lys 
145                 150                 155                 160 

Asn Thr Val Ala Val Val Ser Asp Gly Ser Ala Val Leu Gly Leu Gly 
                165                 170                 175     

Asn Ile Gly Pro Glu Ala Ala Met Pro Val Met Glu Gly Lys Ala Met 
            180                 185                 190         

Leu Phe Lys Arg Phe Ala Asp Val Asp Ala Phe Pro Ile Cys Leu Ala 
        195                 200                 205             

Thr Gln Asp Val Asp Glu Ile Val Glu Thr Val Glu Arg Met Ala Pro 
    210                 215                 220                 

Ser Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe 
225                 230                 235                 240 

Glu Ile Glu Glu Arg Leu Arg Lys Arg Leu Asp Ile Pro Val Phe His 
                245                 250                 255     

Asp Asp Gln His Gly Thr Ala Val Val Met Leu Ala Gly Leu Ile Asn 
            260                 265                 270         

Ala Leu Lys Ile Val Asn Lys Arg Met Gln Asp Val Ser Val Val Val 
        275                 280                 285             

Ala Gly Val Gly Ala Ala Gly Val Ala Cys Thr Lys Ile Leu Leu Ala 
    290                 295                 300                 

Ala Gly Val Gly His Ile Val Gly Val Asp Arg Val Gly Ile Ile Glu 
305                 310                 315                 320 

Arg Gly Arg His Tyr Asp Asn Pro Val Lys Gln Trp Tyr Ala Glu Asn 
                325                 330                 335     

Thr Asn Ser Glu Asn Arg Arg Gly Thr Leu Glu Glu Ala Val Arg Gly 
            340                 345                 350         

Ala Asp Val Phe Ile Gly Val Ser Gly Pro Gly Ile Leu Thr Val Gly 
        355                 360                 365             

His Val Lys Gln Met Ala Arg Asp Pro Ile Val Phe Ala Met Ala Asn 
    370                 375                 380                 

Pro Ile Pro Glu Ile Leu Pro Glu Val Ala Ala Gly His Val Arg Val 
385                 390                 395                 400 

Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn Asn Val Leu 
                405                 410                 415     

Cys Phe Pro Gly Met Phe Arg Gly Ala Leu Asp Val Arg Ala Arg Asp 
            420                 425                 430         

Ile Thr Glu Glu Met Lys Gln Ala Ala Ala Leu Ala Ile Ala Glu Cys 
        435                 440                 445             

Val Pro Glu Glu Gln Leu Ser Glu Gln Tyr Ile Ile Pro Ser Pro Phe 
    450                 455                 460                 

Asp Pro Asn Val Ile Pro Ala Val Ser Arg Ala Val Gln Ala Ala Ala 
465                 470                 475                 480 

Val Arg Ser Gly Val Ala Arg Ala Ala Ala Pro Leu Glu Leu Glu Glu 
                485                 490                 495     

Glu Pro Leu Tyr Thr Glu Met 
            500             

<210>   383
<211>   503
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   383
Met Phe Gln Ser Ala Trp Leu Met Arg Met Ala Glu Pro Trp Pro Glu 
                5                   10                  15      

Thr Gln Gly Glu Trp Asn Val Thr Leu Thr Arg Ala Gly Asn Ile Arg 
            20                  25                  30          

Val Leu Phe Arg Val Arg Leu Glu Ala Gly Ala Ala Leu Gly Glu Val 
        35                  40                  45              

His Gly Ala Ile Val Arg Ala Gly Gly Glu Ile Val Ala Met Glu Thr 
    50                  55                  60                  

Arg Ala Leu His Ala Asp His Ser Val Arg Asp Ile Thr Val Ala Val 
65                  70                  75                  80  

Asp Thr Glu Pro Asp Val Arg Ala Val Glu Gln Ala Leu Asp Glu Val 
                85                  90                  95      

Gln Gly Val Lys Arg Leu Glu Thr Leu Asp Arg Thr Phe Leu Val His 
            100                 105                 110         

Val Gly Gly Lys Ile Ala Thr His Leu Lys Val Pro Val Val Asp Arg 
        115                 120                 125             

Asp Asp Leu Ala Val Val Tyr Thr Pro Gly Val Ala Arg Val Cys Glu 
    130                 135                 140                 

Ala Ile Arg Asp Arg Arg Asp Arg Ala Phe Glu Phe Thr Ile Arg Lys 
145                 150                 155                 160 

Asn Thr Val Ala Val Val Ser Asp Gly Ser Ala Val Leu Gly Leu Gly 
                165                 170                 175     

Asn Ile Gly Pro Glu Ala Ala Met Pro Val Met Glu Gly Lys Ala Met 
            180                 185                 190         

Leu Phe Lys Arg Phe Ala Asp Val Asp Ala Phe Pro Ile Cys Leu Ala 
        195                 200                 205             

Thr Gln Asp Val Asp Glu Ile Val Glu Thr Val Glu Arg Met Ala Pro 
    210                 215                 220                 

Ser Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe 
225                 230                 235                 240 

Glu Ile Glu Glu Arg Leu Arg Lys Arg Leu Asp Ile Pro Val Phe His 
                245                 250                 255     

Asp Asp Gln His Gly Thr Ala Val Val Met Leu Ala Gly Leu Ile Asn 
            260                 265                 270         

Ala Leu Lys Ile Val Asn Lys Arg Met Gln Asp Val Ser Val Val Val 
        275                 280                 285             

Ala Gly Val Gly Ala Ala Gly Val Ala Cys Thr Lys Ile Leu Leu Ala 
    290                 295                 300                 

Ala Gly Val Gly His Ile Val Gly Val Asp Arg Val Gly Ile Ile Glu 
305                 310                 315                 320 

Arg Gly Arg His Tyr Asp Asn Pro Val Lys Gln Trp Tyr Ala Glu Asn 
                325                 330                 335     

Thr Asn Ser Glu Asn Arg Arg Gly Thr Leu Glu Glu Ala Val Arg Gly 
            340                 345                 350         

Ala Asp Val Phe Ile Gly Val Ser Gly Pro Gly Ile Leu Thr Val Gly 
        355                 360                 365             

His Val Lys Gln Met Ala Arg Asp Pro Ile Val Phe Ala Met Ala Asn 
    370                 375                 380                 

Pro Ile Pro Glu Ile Leu Pro Glu Val Ala Ala Gly His Val Arg Val 
385                 390                 395                 400 

Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn Asn Val Leu 
                405                 410                 415     

Cys Phe Pro Gly Met Phe Arg Gly Ala Leu Asp Val Arg Ala Arg Asp 
            420                 425                 430         

Ile Thr Glu Glu Met Lys Gln Ala Ala Ala Leu Ala Ile Ala Glu Cys 
        435                 440                 445             

Val Pro Glu Glu Gln Leu Ser Glu Gln Tyr Ile Ile Pro Ser Pro Phe 
    450                 455                 460                 

Asp Pro Asn Val Val Pro Ala Val Ser Arg Ala Val Gln Ala Ala Ala 
465                 470                 475                 480 

Val Arg Ser Gly Val Ala Arg Ala Ala Ala Pro Leu Glu Leu Glu Glu 
                485                 490                 495     

Glu Pro Leu Tyr Thr Glu Met 
            500             

<210>   384
<211>   503
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   384
Met Phe Gln Ser Ala Trp Leu Met Arg Met Ala Glu Pro Trp Pro Glu 
                5                   10                  15      

Thr Gln Gly Glu Trp Asn Val Thr Leu Thr Arg Ala Gly Asn Val Arg 
            20                  25                  30          

Val Leu Phe Lys Val Arg Leu Glu Ala Gly Ala Ala Leu Gly Glu Val 
        35                  40                  45              

His Gly Ala Ile Val Arg Ala Gly Gly Glu Ile Val Ala Met Glu Thr 
    50                  55                  60                  

Arg Ala Leu His Ala Asp His Ser Val Arg Asp Ile Thr Val Ala Val 
65                  70                  75                  80  

Asp Thr Glu Pro Asp Val Arg Ala Val Glu Gln Ala Leu Asp Glu Val 
                85                  90                  95      

Gln Gly Val Lys Arg Leu Glu Thr Leu Asp Arg Thr Phe Leu Val His 
            100                 105                 110         

Val Gly Gly Lys Ile Ala Thr His Leu Lys Val Pro Val Val Asp Arg 
        115                 120                 125             

Asp Asp Leu Ala Val Val Tyr Thr Pro Gly Val Ala Arg Val Cys Glu 
    130                 135                 140                 

Ala Ile Arg Asp Arg Arg Asp Arg Ala Phe Glu Phe Thr Ile Arg Lys 
145                 150                 155                 160 

Asn Thr Val Ala Val Val Ser Asp Gly Ser Ala Val Leu Gly Leu Gly 
                165                 170                 175     

Asn Ile Gly Pro Glu Ala Ala Met Pro Val Met Glu Gly Lys Ala Met 
            180                 185                 190         

Leu Phe Lys Arg Phe Ala Asp Val Asp Ala Phe Pro Ile Cys Leu Ala 
        195                 200                 205             

Thr Gln Asp Val Asp Glu Ile Val Glu Thr Val Glu Arg Met Ala Pro 
    210                 215                 220                 

Ser Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe 
225                 230                 235                 240 

Glu Ile Glu Glu Arg Leu Arg Lys Arg Leu Asp Ile Pro Val Phe His 
                245                 250                 255     

Asp Asp Gln His Gly Thr Ala Val Val Met Leu Ala Gly Leu Ile Asn 
            260                 265                 270         

Ala Leu Lys Ile Val Asn Lys Arg Met Gln Asp Val Ser Val Val Val 
        275                 280                 285             

Ala Gly Val Gly Ala Ala Gly Val Ala Cys Thr Lys Ile Leu Leu Ala 
    290                 295                 300                 

Ala Gly Val Gly His Ile Val Gly Val Asp Arg Val Gly Ile Ile Glu 
305                 310                 315                 320 

Arg Gly Arg His Tyr Asp Asn Pro Val Lys Gln Trp Tyr Ala Glu Asn 
                325                 330                 335     

Thr Asn Ser Glu Asn Arg Arg Gly Thr Leu Glu Glu Ala Val Arg Gly 
            340                 345                 350         

Ala Asp Val Phe Ile Gly Val Ser Gly Pro Gly Ile Leu Thr Val Gly 
        355                 360                 365             

His Val Lys Gln Met Ala Arg Asp Pro Ile Val Phe Ala Met Ala Asn 
    370                 375                 380                 

Pro Ile Pro Glu Ile Leu Pro Glu Val Ala Ala Gly His Val Arg Val 
385                 390                 395                 400 

Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn Asn Val Leu 
                405                 410                 415     

Cys Phe Pro Gly Met Phe Arg Gly Ala Leu Asp Val Arg Ala Arg Asp 
            420                 425                 430         

Ile Thr Glu Glu Met Lys Gln Ala Ala Ala Leu Ala Ile Ala Glu Cys 
        435                 440                 445             

Val Pro Glu Glu Gln Leu Ser Glu Gln Tyr Ile Ile Pro Ser Pro Phe 
    450                 455                 460                 

Asp Pro Asn Val Val Pro Ala Val Ser Arg Ala Val Gln Ala Ala Ala 
465                 470                 475                 480 

Val Arg Ser Gly Val Ala Arg Ala Ala Ala Pro Leu Glu Leu Glu Glu 
                485                 490                 495     

Glu Pro Leu Tyr Thr Glu Met 
            500             

<210>   385
<211>   503
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   385
Met Phe Gln Ser Ala Trp Leu Met Arg Met Ala Glu Pro Trp Pro Glu 
                5                   10                  15      

Thr Gln Gly Glu Trp Asn Val Thr Leu Thr Lys Ala Gly Asn Val Arg 
            20                  25                  30          

Val Leu Phe Arg Val Arg Leu Glu Ala Gly Ala Ala Leu Gly Glu Val 
        35                  40                  45              

His Gly Ala Ile Val Arg Ala Gly Gly Glu Ile Val Ala Met Glu Thr 
    50                  55                  60                  

Arg Ala Leu His Ala Asp His Ser Val Arg Asp Ile Thr Val Ala Val 
65                  70                  75                  80  

Asp Thr Glu Pro Asp Val Arg Ala Val Glu Gln Ala Leu Asp Glu Val 
                85                  90                  95      

Gln Gly Val Lys Arg Leu Glu Thr Leu Asp Arg Thr Phe Leu Val His 
            100                 105                 110         

Val Gly Gly Lys Ile Ala Thr His Leu Lys Val Pro Val Val Asp Arg 
        115                 120                 125             

Asp Asp Leu Ala Val Val Tyr Thr Pro Gly Val Ala Arg Val Cys Glu 
    130                 135                 140                 

Ala Ile Arg Asp Arg Arg Asp Arg Ala Phe Glu Phe Thr Ile Arg Lys 
145                 150                 155                 160 

Asn Thr Val Ala Val Val Ser Asp Gly Ser Ala Val Leu Gly Leu Gly 
                165                 170                 175     

Asn Ile Gly Pro Glu Ala Ala Met Pro Val Met Glu Gly Lys Ala Met 
            180                 185                 190         

Leu Phe Lys Arg Phe Ala Asp Val Asp Ala Phe Pro Ile Cys Leu Ala 
        195                 200                 205             

Thr Gln Asp Val Asp Glu Ile Val Glu Thr Val Glu Arg Met Ala Pro 
    210                 215                 220                 

Ser Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe 
225                 230                 235                 240 

Glu Ile Glu Glu Arg Leu Arg Lys Arg Leu Asp Ile Pro Val Phe His 
                245                 250                 255     

Asp Asp Gln His Gly Thr Ala Val Val Met Leu Ala Gly Leu Ile Asn 
            260                 265                 270         

Ala Leu Lys Ile Val Asn Lys Arg Met Gln Asp Val Ser Val Val Val 
        275                 280                 285             

Ala Gly Val Gly Ala Ala Gly Val Ala Cys Thr Lys Ile Leu Leu Ala 
    290                 295                 300                 

Ala Gly Val Gly His Ile Val Gly Val Asp Arg Val Gly Ile Ile Glu 
305                 310                 315                 320 

Arg Gly Arg His Tyr Asp Asn Pro Val Lys Gln Trp Tyr Ala Glu Asn 
                325                 330                 335     

Thr Asn Ser Glu Asn Arg Arg Gly Thr Leu Glu Glu Ala Val Arg Gly 
            340                 345                 350         

Ala Asp Val Phe Ile Gly Val Ser Gly Pro Gly Ile Leu Thr Val Gly 
        355                 360                 365             

His Val Lys Gln Met Ala Arg Asp Pro Ile Val Phe Ala Met Ala Asn 
    370                 375                 380                 

Pro Ile Pro Glu Ile Leu Pro Glu Val Ala Ala Gly His Val Arg Val 
385                 390                 395                 400 

Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn Asn Val Leu 
                405                 410                 415     

Cys Phe Pro Gly Met Phe Arg Gly Ala Leu Asp Val Arg Ala Arg Asp 
            420                 425                 430         

Ile Thr Glu Glu Met Lys Gln Ala Ala Ala Leu Ala Ile Ala Glu Cys 
        435                 440                 445             

Val Pro Glu Glu Gln Leu Ser Glu Gln Tyr Ile Ile Pro Ser Pro Phe 
    450                 455                 460                 

Asp Pro Asn Val Val Pro Ala Val Ser Arg Ala Val Gln Ala Ala Ala 
465                 470                 475                 480 

Val Arg Ser Gly Val Ala Arg Ala Ala Ala Pro Leu Glu Leu Glu Glu 
                485                 490                 495     

Glu Pro Leu Tyr Thr Glu Met 
            500             

<210>   386
<211>   503
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   386
Met Phe Gln Ser Ala Trp Leu Met Arg Met Ala Glu Pro Trp Pro Glu 
                5                   10                  15      

Thr Gln Gly Glu Trp Asn Val Thr Leu Thr Arg Ala Gly Asn Val Arg 
            20                  25                  30          

Val Leu Phe Arg Val Arg Leu Glu Ala Gly Ala Ala Leu Gly Glu Val 
        35                  40                  45              

His Gly Ala Ile Val Arg Ala Gly Gly Glu Ile Val Ala Met Glu Thr 
    50                  55                  60                  

Arg Ala Leu His Ala Asp His Ser Val Arg Asp Ile Thr Val Ala Val 
65                  70                  75                  80  

Asp Thr Glu Pro Asp Val Arg Ala Val Asp Gln Ala Leu Asp Glu Val 
                85                  90                  95      

Gln Gly Val Lys Arg Leu Glu Thr Leu Asp Arg Thr Phe Leu Val His 
            100                 105                 110         

Val Gly Gly Lys Ile Ala Thr His Leu Lys Val Pro Val Val Asp Arg 
        115                 120                 125             

Asp Asp Leu Ala Val Val Tyr Thr Pro Gly Val Ala Arg Val Cys Glu 
    130                 135                 140                 

Ala Ile Arg Asp Arg Arg Asp Arg Ala Phe Glu Phe Thr Ile Arg Lys 
145                 150                 155                 160 

Asn Thr Val Ala Val Val Ser Asp Gly Ser Ala Val Leu Gly Leu Gly 
                165                 170                 175     

Asn Ile Gly Pro Glu Ala Ala Met Pro Val Met Glu Gly Lys Ala Met 
            180                 185                 190         

Leu Phe Lys Arg Phe Ala Asp Val Asp Ala Phe Pro Ile Cys Leu Ala 
        195                 200                 205             

Thr Gln Asp Val Asp Glu Ile Val Glu Thr Val Glu Arg Met Ala Pro 
    210                 215                 220                 

Ser Phe Gly Gly Ile Asn Leu Glu Asp Ile Ser Ser Pro Arg Cys Phe 
225                 230                 235                 240 

Glu Ile Glu Glu Arg Leu Arg Lys Arg Leu Asp Ile Pro Val Phe His 
                245                 250                 255     

Asp Asp Gln His Gly Thr Ala Val Val Met Leu Ala Gly Leu Ile Asn 
            260                 265                 270         

Ala Leu Lys Ile Val Asn Lys Arg Met Gln Asp Val Ser Val Val Val 
        275                 280                 285             

Ala Gly Val Gly Ala Ala Gly Val Ala Cys Thr Lys Ile Leu Leu Ala 
    290                 295                 300                 

Ala Gly Val Gly His Ile Val Gly Val Asp Arg Val Gly Ile Ile Glu 
305                 310                 315                 320 

Arg Gly Arg His Tyr Asp Asn Pro Val Lys Gln Trp Tyr Ala Glu Asn 
                325                 330                 335     

Thr Asn Ser Glu Asn Arg Arg Gly Thr Leu Glu Glu Ala Val Arg Gly 
            340                 345                 350         

Ala Asp Val Phe Ile Gly Val Ser Gly Pro Gly Ile Leu Thr Val Gly 
        355                 360                 365             

His Val Lys Gln Met Ala Arg Asp Pro Ile Val Phe Ala Met Ala Asn 
    370                 375                 380                 

Pro Ile Pro Glu Ile Leu Pro Glu Val Ala Ala Gly His Val Arg Val 
385                 390                 395                 400 

Met Ala Thr Gly Arg Ser Asp Tyr Pro Asn Gln Ile Asn Asn Val Leu 
                405                 410                 415     

Cys Phe Pro Gly Met Phe Arg Gly Ala Leu Asp Val Arg Ala Arg Asp 
            420                 425                 430         

Ile Thr Glu Glu Met Lys Gln Ala Ala Ala Leu Ala Ile Ala Glu Cys 
        435                 440                 445             

Val Pro Glu Glu Gln Leu Ser Glu Gln Tyr Ile Ile Pro Ser Pro Phe 
    450                 455                 460                 

Asp Pro Asn Val Val Pro Ala Val Ser Arg Ala Val Gln Ala Ala Ala 
465                 470                 475                 480 

Val Arg Ser Gly Val Ala Arg Ala Ala Ala Pro Leu Glu Leu Glu Glu 
                485                 490                 495     

Glu Pro Leu Tyr Thr Glu Met 
            500             

<210>   387
<211>   1512
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   387
gtgtttcaat ccgcctggct gatgcggatg gcggagccgt ggcccgaaac tcagggggag       60

tggaacgtga cactgacgcg tgccggcaat gttcgagttc tgtttcgcgt tcgcttggag      120

gcgggcgcgg cgcttgggga ggtgcatggc gccattgtgc gcgccggagg cgagatcgtc      180

gccatggaga cccgcgcgct gcatgcggat cacagcgtgc gcgacatcac cgtcgcggtc      240

gataccgagc ccgatgtccg ggctgtcgag caagcgctgg acgaggtaca gggcgtgaaa      300

cgcctggaga cgctggaccg cacatttctg gtccacgtgg ggggcaaaat cgccacacac      360

ctgaaggtgc ccgtggtcga tcgcgacgac ctggccgttg tgtacacgcc gggcgtggcg      420

cgcgtgtgcg aggccattcg ggatcgccgc gatcgcgcct tcgaattcac catccgcaag      480

aacacggtgg cggtggtgag cgacggctcg gccgtgctag ggctggggaa cattggcccg      540

gaggccgcca tgccggtcat ggaagggaag gcgatgctgt tcaagcgctt cgccgacgtg      600

gatgccttcc ccatctgctt ggccacgcag gacgtggacg agattgtcga aaccgtcgag      660

cgaatggcgc cgtcgttcgg cgggatcaac ctcgaggaca tctcgtcgcc gcggtgtttc      720

gagatcgagg agcggctgcg gaaacggctc gacattccgg tgtttcacga cgatcagcac      780

ggcacagcgg tcgtcatgct ggccgggctc atcaatgcac tgaagattgt gaacaagcgg      840

atgcaggatg tgtccgtcgt cgtggcgggg gtcggcgcgg caggcgtggc gtgcaccaag      900

atcctgctcg cggccggtgt ggggcatatc gtcggcgtgg atcgcgtagg catcatcgag      960

cgcggccgcc actatgacaa ccccgtgaag cagtggtacg cggagaacac gaactccgag     1020

aatcggcgcg ggaccctcga agaagcggtg cgcggcgccg acgtgttcat cggcgtctcc     1080

ggcccgggca tcctgaccgt cggtcacgtc aagcaaatgg cgcgcgatcc cattgtgttt     1140

gccatggcga atcccatccc ggaaatcctg cccgaggtgg cggcgggcca cgtgcgcgtg     1200

atggcgaccg gacgatccga ctacccgaat cagattaaca acgtgctctg ttttcccggc     1260

atgttccgcg gggcgctcga cgtccgcgcg cgggatatca cggaagagat gaaacaggcc     1320

gcggcgctcg ccatcgccga gtgcgtgccg gaagagcaac tgtcggagca gtacatcatc     1380

ccgagcccgt tcgatccgaa cgtcattccg gccgtgagcc gcgcggtgca agcagccgcg     1440

gttcggtccg gcgtggcgcg ggcggcagct cccctcgagc tcgaggaaga gcccctctac     1500

accgagatgt ag                                                         1512


<210>   388
<211>   1512
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   388
gtgtttcaat ccgcctggct gatgcggatg gcggagccgt ggcccgaaac tcagggggag       60

tggaacgtga cactgacgcg tgccggcaat attcgagttc tgtttcgcgt tcgcttggag      120

gcgggcgcgg cgcttgggga ggtgcatggc gccattgtgc gcgccggagg cgagatcgtc      180

gccatggaga cccgcgcgct gcatgcggat cacagcgtgc gcgacatcac cgtcgcggtc      240

gataccgagc ccgatgtccg ggctgtcgag caagcgctgg acgaggtaca gggcgtgaaa      300

cgcctggaga cgctggaccg cacatttctg gtccacgtgg ggggcaaaat cgccacacac      360

ctgaaggtgc ccgtggtcga tcgcgacgac ctggccgttg tgtacacgcc gggcgtggcg      420

cgcgtgtgcg aggccattcg ggatcgccgc gatcgcgcct tcgaattcac catccgcaag      480

aacacggtgg cggtggtgag cgacggctcg gccgtgctag ggctggggaa cattggcccg      540

gaggccgcca tgccggtcat ggaagggaag gcgatgctgt tcaagcgctt cgccgacgtg      600

gatgccttcc ccatctgctt ggccacgcag gacgtggacg agattgtcga aaccgtcgag      660

cgaatggcgc cgtcgttcgg cgggatcaac ctcgaggaca tctcgtcgcc gcggtgtttc      720

gagatcgagg agcggctgcg gaaacggctc gacattccgg tgtttcacga cgatcagcac      780

ggcacagcgg tcgtcatgct ggccgggctc atcaatgcac tgaagattgt gaacaagcgg      840

atgcaggatg tgtccgtcgt cgtggcgggg gtcggcgcgg caggcgtggc gtgcaccaag      900

atcctgctcg cggccggtgt ggggcatatc gtcggcgtgg atcgcgtagg catcatcgag      960

cgcggccgcc actatgacaa ccccgtgaag cagtggtacg cggagaacac gaactccgag     1020

aatcggcgcg ggaccctcga agaagcggtg cgcggcgccg acgtgttcat cggcgtctcc     1080

ggcccgggca tcctgaccgt cggtcacgtc aagcaaatgg cgcgcgatcc cattgtgttt     1140

gccatggcga atcccatccc ggaaatcctg cccgaggtgg cggcgggcca cgtgcgcgtg     1200

atggcgaccg gacgatccga ctacccgaat cagattaaca acgtgctctg ttttcccggc     1260

atgttccgcg gggcgctcga cgtccgcgcg cgggatatca cggaagagat gaaacaggcc     1320

gcggcgctcg ccatcgccga gtgcgtgccg gaagagcaac tgtcggagca gtacatcatc     1380

ccgagcccgt tcgatccgaa cgtcgtcccg gccgtgagcc gcgcggtgca agcagccgcg     1440

gttcggtccg gcgtggcgcg ggcggcagct cccctcgagc tcgaggaaga gcccctctac     1500

accgagatgt ag                                                         1512


<210>   389
<211>   1512
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   389
gtgtttcaat ccgcctggct gatgcggatg gcggagccgt ggcccgaaac tcagggggag       60

tggaacgtga cactgacgcg tgccggcaat gttcgagttc tgtttaaagt tcgcttggag      120

gcgggcgcgg cgcttgggga ggtgcatggc gccattgtgc gcgccggagg cgagatcgtc      180

gccatggaga cccgcgcgct gcatgcggat cacagcgtgc gcgacatcac cgtcgcggtc      240

gataccgagc ccgatgtccg ggctgtcgag caagcgctgg acgaggtaca gggcgtgaaa      300

cgcctggaga cgctggaccg cacatttctg gtccacgtgg ggggcaaaat cgccacacac      360

ctgaaggtgc ccgtggtcga tcgcgacgac ctggccgttg tgtacacgcc gggcgtggcg      420

cgcgtgtgcg aggccattcg ggatcgccgc gatcgcgcct tcgaattcac catccgcaag      480

aacacggtgg cggtggtgag cgacggctcg gccgtgctag ggctggggaa cattggcccg      540

gaggccgcca tgccggtcat ggaagggaag gcgatgctgt tcaagcgctt cgccgacgtg      600

gatgccttcc ccatctgctt ggccacgcag gacgtggacg agattgtcga aaccgtcgag      660

cgaatggcgc cgtcgttcgg cgggatcaac ctcgaggaca tctcgtcgcc gcggtgtttc      720

gagatcgagg agcggctgcg gaaacggctc gacattccgg tgtttcacga cgatcagcac      780

ggcacagcgg tcgtcatgct ggccgggctc atcaatgcac tgaagattgt gaacaagcgg      840

atgcaggatg tgtccgtcgt cgtggcgggg gtcggcgcgg caggcgtggc gtgcaccaag      900

atcctgctcg cggccggtgt ggggcatatc gtcggcgtgg atcgcgtagg catcatcgag      960

cgcggccgcc actatgacaa ccccgtgaag cagtggtacg cggagaacac gaactccgag     1020

aatcggcgcg ggaccctcga agaagcggtg cgcggcgccg acgtgttcat cggcgtctcc     1080

ggcccgggca tcctgaccgt cggtcacgtc aagcaaatgg cgcgcgatcc cattgtgttt     1140

gccatggcga atcccatccc ggaaatcctg cccgaggtgg cggcgggcca cgtgcgcgtg     1200

atggcgaccg gacgatccga ctacccgaat cagattaaca acgtgctctg ttttcccggc     1260

atgttccgcg gggcgctcga cgtccgcgcg cgggatatca cggaagagat gaaacaggcc     1320

gcggcgctcg ccatcgccga gtgcgtgccg gaagagcaac tgtcggagca gtacatcatc     1380

ccgagcccgt tcgatccgaa cgtcgtcccg gccgtgagcc gcgcggtgca agcagccgcg     1440

gttcggtccg gcgtggcgcg ggcggcagct cccctcgagc tcgaggaaga gcccctctac     1500

accgagatgt ag                                                         1512


<210>   390
<211>   1512
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   390
gtgtttcaat ccgcctggct gatgcggatg gcggagccgt ggcccgaaac tcagggggag       60

tggaacgtga cactgacgaa agccggcaat gttcgagttc tgtttcgcgt tcgcttggag      120

gcgggcgcgg cgcttgggga ggtgcatggc gccattgtgc gcgccggagg cgagatcgtc      180

gccatggaga cccgcgcgct gcatgcggat cacagcgtgc gcgacatcac cgtcgcggtc      240

gataccgagc ccgatgtccg ggctgtcgag caagcgctgg acgaggtaca gggcgtgaaa      300

cgcctggaga cgctggaccg cacatttctg gtccacgtgg ggggcaaaat cgccacacac      360

ctgaaggtgc ccgtggtcga tcgcgacgac ctggccgttg tgtacacgcc gggcgtggcg      420

cgcgtgtgcg aggccattcg ggatcgccgc gatcgcgcct tcgaattcac catccgcaag      480

aacacggtgg cggtggtgag cgacggctcg gccgtgctag ggctggggaa cattggcccg      540

gaggccgcca tgccggtcat ggaagggaag gcgatgctgt tcaagcgctt cgccgacgtg      600

gatgccttcc ccatctgctt ggccacgcag gacgtggacg agattgtcga aaccgtcgag      660

cgaatggcgc cgtcgttcgg cgggatcaac ctcgaggaca tctcgtcgcc gcggtgtttc      720

gagatcgagg agcggctgcg gaaacggctc gacattccgg tgtttcacga cgatcagcac      780

ggcacagcgg tcgtcatgct ggccgggctc atcaatgcac tgaagattgt gaacaagcgg      840

atgcaggatg tgtccgtcgt cgtggcgggg gtcggcgcgg caggcgtggc gtgcaccaag      900

atcctgctcg cggccggtgt ggggcatatc gtcggcgtgg atcgcgtagg catcatcgag      960

cgcggccgcc actatgacaa ccccgtgaag cagtggtacg cggagaacac gaactccgag     1020

aatcggcgcg ggaccctcga agaagcggtg cgcggcgccg acgtgttcat cggcgtctcc     1080

ggcccgggca tcctgaccgt cggtcacgtc aagcaaatgg cgcgcgatcc cattgtgttt     1140

gccatggcga atcccatccc ggaaatcctg cccgaggtgg cggcgggcca cgtgcgcgtg     1200

atggcgaccg gacgatccga ctacccgaat cagattaaca acgtgctctg ttttcccggc     1260

atgttccgcg gggcgctcga cgtccgcgcg cgggatatca cggaagagat gaaacaggcc     1320

gcggcgctcg ccatcgccga gtgcgtgccg gaagagcaac tgtcggagca gtacatcatc     1380

ccgagcccgt tcgatccgaa cgtcgtcccg gccgtgagcc gcgcggtgca agcagccgcg     1440

gttcggtccg gcgtggcgcg ggcggcagct cccctcgagc tcgaggaaga gcccctctac     1500

accgagatgt ag                                                         1512


<210>   391
<211>   1512
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   391
gtgtttcaat ccgcctggct gatgcggatg gcggagccgt ggcccgaaac tcagggggag       60

tggaacgtga cactgacgcg tgccggcaat gttcgagttc tgtttcgcgt tcgcttggag      120

gcgggcgcgg cgcttgggga ggtgcatggc gccattgtgc gcgccggagg cgagatcgtc      180

gccatggaga cccgcgcgct gcatgcggat cacagcgtgc gcgacatcac cgtcgcggtc      240

gataccgagc ccgatgtccg ggctgtcgat caagcgctgg acgaggtaca gggcgtgaaa      300

cgcctggaga cgctggaccg cacatttctg gtccacgtgg ggggcaaaat cgccacacac      360

ctgaaggtgc ccgtggtcga tcgcgacgac ctggccgttg tgtacacgcc gggcgtggcg      420

cgcgtgtgcg aggccattcg ggatcgccgc gatcgcgcct tcgaattcac catccgcaag      480

aacacggtgg cggtggtgag cgacggctcg gccgtgctag ggctggggaa cattggcccg      540

gaggccgcca tgccggtcat ggaagggaag gcgatgctgt tcaagcgctt cgccgacgtg      600

gatgccttcc ccatctgctt ggccacgcag gacgtggacg agattgtcga aaccgtcgag      660

cgaatggcgc cgtcgttcgg cgggatcaac ctcgaggaca tctcgtcgcc gcggtgtttc      720

gagatcgagg agcggctgcg gaaacggctc gacattccgg tgtttcacga cgatcagcac      780

ggcacagcgg tcgtcatgct ggccgggctc atcaatgcac tgaagattgt gaacaagcgg      840

atgcaggatg tgtccgtcgt cgtggcgggg gtcggcgcgg caggcgtggc gtgcaccaag      900

atcctgctcg cggccggtgt ggggcatatc gtcggcgtgg atcgcgtagg catcatcgag      960

cgcggccgcc actatgacaa ccccgtgaag cagtggtacg cggagaacac gaactccgag     1020

aatcggcgcg ggaccctcga agaagcggtg cgcggcgccg acgtgttcat cggcgtctcc     1080

ggcccgggca tcctgaccgt cggtcacgtc aagcaaatgg cgcgcgatcc cattgtgttt     1140

gccatggcga atcccatccc ggaaatcctg cccgaggtgg cggcgggcca cgtgcgcgtg     1200

atggcgaccg gacgatccga ctacccgaat cagattaaca acgtgctctg ttttcccggc     1260

atgttccgcg gggcgctcga cgtccgcgcg cgggatatca cggaagagat gaaacaggcc     1320

gcggcgctcg ccatcgccga gtgcgtgccg gaagagcaac tgtcggagca gtacatcatc     1380

ccgagcccgt tcgatccgaa cgtcgtcccg gccgtgagcc gcgcggtgca agcagccgcg     1440

gttcggtccg gcgtggcgcg ggcggcagct cccctcgagc tcgaggaaga gcccctctac     1500

accgagatgt ag                                                         1512


<210>   392
<211>   395
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   392
Met Gln Asp Val Val Ile Ala Gly Ala Val Arg Thr Pro Ile Gly Thr 
                5                   10                  15      

Phe Gln Gly Ser Leu Ser Pro Leu Ser Ala Pro Asp Leu Gly Ala Ala 
            20                  25                  30          

Val Ile Arg Glu Ser Leu Arg Arg Ala Gly Val Glu Ala Gly Ala Val 
        35                  40                  45              

Asp Glu Val Val Met Gly Asn Val Leu Gln Ala Gly Val Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Met Arg Ala Gly Leu Pro Glu Asp Ile Pro 
65                  70                  75                  80  

Ala Thr Thr Val Asn Met Val Cys Gly Ser Gly Leu Lys Ser Val Met 
                85                  90                  95      

Leu Ala Ala Gln Ala Ile Arg Ala Gly Asp Ala Asp Val Leu Val Ala 
            100                 105                 110         

Gly Gly Met Glu Ser Met Ser Asn Ala Pro Tyr Leu Leu Pro Gly Ala 
        115                 120                 125             

Arg Glu Gly Tyr Arg Met Gly His Arg Glu Val Val Asp Ser Met Ile 
    130                 135                 140                 

Arg Asp Gly Leu Trp Cys Ala Phe Cys Asp Ile His Met Gly Val Thr 
145                 150                 155                 160 

Ala Glu Asn Val Ala Asn Arg His Gly Ile Ser Arg Glu Asp Gln Asp 
                165                 170                 175     

Arg Phe Ala Leu Gln Ser Gln Met Arg Ala Lys Glu Ala Met Glu Ala 
            180                 185                 190         

Gly Arg Phe Lys Asp Glu Ile Val Pro Val Ser Val Pro Arg Arg Lys 
        195                 200                 205             

Gly Glu Pro Thr Leu Val Asp Cys Asp Glu His Pro Arg Pro Asp Thr 
    210                 215                 220                 

Thr Tyr Glu Ala Leu Ala Lys Leu Arg Pro Ala Phe Gln Ala Asp Gly 
225                 230                 235                 240 

Thr Val Ile Ala Gly Asn Ser Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     

Met Leu Val Leu Ala Arg Asp Arg Ala Glu Ala Leu Gly Val Lys Pro 
            260                 265                 270         

Met Ala Arg Ile Val Ser Tyr Ala Ser Val Gly Leu Asp Pro Ser Val 
        275                 280                 285             

Met Gly Leu Gly Pro Ile Glu Ala Thr Arg Arg Ala Leu Gly Arg Ala 
    290                 295                 300                 

Gly Leu Ser Val Glu Asp Leu Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Ala Arg Glu Leu Ser Phe Pro Asp Asp 
                325                 330                 335     

Lys Leu Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu Tyr Glu Leu Glu Arg 
        355                 360                 365             

Arg Gly Gly Arg Phe Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 

Gly Val Ala Met Val Val Glu Arg Met Ser Gln 
385                 390                 395 

<210>   393
<211>   1188
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   393
gtgcaagacg tggtgattgc aggggcagtg cggacgccca tcggaacgtt ccagggaagt       60

ctctcgcccc tttcggcgcc ggatctcggt gcggccgtga tccgggagtc gctgcggcgc      120

gcgggagttg aggccggggc cgtggacgaa gtcgtgatgg gcaacgtgct gcaggcgggc      180

gtcggccaga atccagcgcg gcaagcggcg atgcgcgcgg ggctgccgga agacatcccg      240

gcgacgacgg tgaacatggt gtgcggatcg ggcctaaagt cggtcatgct cgcggcgcag      300

gccattcgcg ccggggacgc ggacgtcttg gtggcgggcg gcatggagtc gatgtcgaac      360

gcgccgtacc tgcttccagg ggcgcgcgag ggctaccgca tgggccatcg cgaagtggtc      420

gacagcatga tccgggatgg cttgtggtgc gcgttttgcg acatccacat gggcgtcact      480

gccgaaaacg tggcgaatcg ccacggcatc agccgcgagg atcaggaccg attcgcgctg      540

cagagccaga tgcgcgccaa ggaagcgatg gaggcaggcc ggttcaagga cgagatcgtg      600

cccgtctccg tgccgcggcg gaagggcgag ccgaccttgg tcgattgcga cgaacatccg      660

cgtcccgaca cgacgtacga ggcgctggcg aagcttcggc ccgcgtttca ggcggacggc      720

accgtgatcg ccggcaacag ctcgggcatc aacgacggcg cggcggccat gctggtgctc      780

gcccgggatc gcgccgaggc gttgggcgtg aagccgatgg cgcggatcgt gagctacgcg      840

agcgtgggct tggatccgag cgtgatgggc ctcggtccca tcgaggcgac gcgccgagcg      900

ctcggccggg cggggctttc cgtggaagac ctcgacctca tcgaggcgaa tgaggcgttc      960

gccgcccagg cgctcgcggt ggctcgggaa ctgtcgttcc cggatgacaa gttgaacgtg     1020

aacggcggcg ccatcgcgct cggccacccc atcggcgcga gcggtgcccg gatcttggtc     1080

acgctgcttt acgagctcga gcgccgcggc ggccgtttcg gcctcgccac actgtgcatc     1140

ggcggcggac agggcgtggc catggtcgtg gagcgcatgt cgcagtga                  1188


<210>   394
<211>   393
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   394
Met Glu Glu Val Val Ile Val Ser Ala Val Arg Thr Pro Ile Gly Ser 
                5                   10                  15      

Phe Leu Gly Ser Leu Ala Gln Thr Pro Ala Val Asp Leu Gly Ala Leu 
            20                  25                  30          

Val Ile Lys Glu Ser Leu Asn Arg Ile Asn Leu Ala Pro Arg Phe Val 
        35                  40                  45              

Asp Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Ile Lys Ala Gly Ile Pro Gln Glu Val Pro 
65                  70                  75                  80  

Ala Phe Thr Val Asn Lys Val Cys Gly Ser Gly Leu Lys Ser Val Gly 
                85                  90                  95      

Leu Ala Tyr Gln Ala Ile Ala Thr Gly Asp Ala Asp Ile Val Val Ala 
            100                 105                 110         

Gly Gly Met Glu Asn Met Ser Leu Ala Pro Tyr Val Leu Pro Lys Ala 
        115                 120                 125             

Arg Thr Gly Tyr Arg Met Gly His Asp Thr Leu Ile Asp Ser Met Ile 
    130                 135                 140                 

Lys Asp Gly Leu Trp Cys Ala Phe Thr Asp Val His Met Gly Ile Thr 
145                 150                 155                 160 

Ala Glu Asn Ile Ala Glu Lys Tyr Asn Ile Thr Arg Glu Glu Gln Asp 
                165                 170                 175     

Lys Phe Ala Leu Gln Ser Gln Glu Arg Ala Ile Lys Ala Ile Asp Glu 
            180                 185                 190         

Gly Lys Phe Lys Glu Glu Ile Val Pro Val Ile Ile Pro Gln Lys Lys 
        195                 200                 205             

Gly Glu Pro Leu Val Phe Ser Thr Asp Glu Phe Pro Lys Arg Gly Thr 
    210                 215                 220                 

Ser Leu Glu Lys Leu Ala Ala Leu Lys Pro Ala Phe Lys Lys Asp Gly 
225                 230                 235                 240 

Thr Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     

Val Val Val Met Ser Ala Lys Lys Ala Gln Glu Leu Asn Ile Lys Pro 
            260                 265                 270         

Leu Ala Val Ile Arg Gly Tyr Ala Ala Ala Gly Val Asp Pro Ala Tyr 
        275                 280                 285             

Met Gly Leu Gly Pro Ile Pro Ala Thr Arg Lys Ala Leu Lys Lys Ala 
    290                 295                 300                 

Asn Leu Thr Val Ser Asp Leu Gly Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Ile Lys Glu Leu Glu Leu Asn Pro Glu 
                325                 330                 335     

Ile Thr Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu His Glu Met Gln Lys 
        355                 360                 365             

Arg Asn Thr Lys Tyr Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 

Gly Phe Ala Leu Val Val Glu Lys Val 
385                 390             

<210>   395
<211>   392
<212>   PRT
<213>   Thermosinus carboxydivorans Nor1

<400>   395
Met Arg Glu Val Val Ile Ala Ser Ala Val Arg Thr Ala Ile Gly Ser 
                5                   10                  15      

Phe Asn Gly Thr Leu Ala Pro Phe Ser Ala Pro Glu Leu Gly Ser Phe 
            20                  25                  30          

Val Ile Lys Ala Ala Leu Glu Arg Ala Asn Val Pro Ala Ser Ala Val 
        35                  40                  45              

Asp Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Leu Lys Ala Gly Leu Pro Val Glu Val Pro 
65                  70                  75                  80  

Thr Met Thr Ile Asn Lys Val Cys Gly Ser Gly Leu Lys Ala Val Asn 
                85                  90                  95      

Leu Ala Ala Gln Ala Ile Met Thr Gly Asp Ala Asp Ile Val Val Ala 
            100                 105                 110         

Gly Gly Met Glu Ser Met Thr Asn Ala Pro Tyr Leu Leu Asp Lys Ser 
        115                 120                 125             

Arg Trp Gly Tyr Arg Met Gly His Gly Lys Leu Ile Asp Ser Met Ile 
    130                 135                 140                 

Thr Asp Gly Leu Trp Cys Ala Phe Asn Asp Tyr His Met Gly Ile Thr 
145                 150                 155                 160 

Ala Glu Asn Ile Val Glu Lys Tyr Gly Val Thr Arg Glu Glu Gln Asp 
                165                 170                 175     

Gln Leu Ala Phe Glu Ser Gln Asp Lys Ala Ile Lys Ala Ile Ala Ser 
            180                 185                 190         

Gly Ala Phe Lys Lys Glu Ile Val Pro Val Val Ile Lys Asp Lys Lys 
        195                 200                 205             

Gly Asp Lys Ile Phe Asp Thr Asp Glu Tyr Pro Arg Ala Gly Thr Thr 
    210                 215                 220                 

Val Glu Lys Leu Cys Ala Leu Lys Pro Ala Phe Lys Lys Asp Gly Thr 
225                 230                 235                 240 

Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala Ala Leu 
                245                 250                 255     

Val Val Met Ser Ala Asp Lys Ala Lys Glu Leu Gly Ile Lys Pro Met 
            260                 265                 270         

Ala Arg Ile Arg Ser Tyr Ala Ser Ala Gly Val Asp Pro Ser Ile Met 
        275                 280                 285             

Gly Met Gly Pro Val Pro Ala Thr Arg Lys Ala Leu Ala Lys Ala Gly 
    290                 295                 300                 

Leu Val Met Asp Asp Ile Asp Leu Ile Glu Ala Asn Glu Ala Phe Ala 
305                 310                 315                 320 

Ala Gln Phe Leu Ala Val Gly Lys Glu Leu Gly Phe Val Lys Glu Lys 
                325                 330                 335     

Val Asn Val His Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly Ala 
            340                 345                 350         

Ser Gly Ala Arg Ile Leu Val Thr Leu Leu His Ala Met Glu Leu Arg 
        355                 360                 365             

Asn Val Lys Thr Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln Gly 
    370                 375                 380                 

Val Ala Thr Ile Val Glu Arg Met 
385                 390         

<210>   396
<211>   391
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   396
Glu Glu Val Val Ile Ala Ser Gly Val Arg Thr Pro Ile Gly Arg Phe 
                5                   10                  15      

Gly Gly His Leu Lys Asp Leu Lys Ala Pro Thr Leu Gly Ala Leu Val 
            20                  25                  30          

Ile Ser Glu Ala Leu His Arg Ala Gly Val Leu Asn Glu Gln Val Asp 
        35                  40                  45              

Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn Pro 
    50                  55                  60                  

Ala Arg Gln Ala Ala Leu Gln Ala Gly Leu Pro Glu Thr Val Pro Ala 
65                  70                  75                  80  

Met Thr Ile Asn Lys Val Cys Gly Ser Gly Leu Lys Ala Val His Leu 
                85                  90                  95      

Ala Ser Gln Ala Ile Ala Cys Gly Asp Ala Glu Ile Val Val Ala Gly 
            100                 105                 110         

Gly Met Glu Asn Met Ser Gln Ala Pro Tyr Leu Ala Val Gly Ala Arg 
        115                 120                 125             

Asn Gly Tyr Arg Met Gly His His Gln Leu Ile Asp Ser Met Ile His 
    130                 135                 140                 

Asp Gly Leu Trp Cys Ala Phe Asn Asp Tyr His Met Gly Ile Thr Ala 
145                 150                 155                 160 

Glu Asn Leu Cys Glu Gln Tyr Gly Leu Ser Arg Thr Glu Leu Asp Glu 
                165                 170                 175     

Phe Ser Ala Trp Ser Gln Glu Lys Ala Val Gln Ala Ile Glu Ser Gly 
            180                 185                 190         

Arg Phe Lys Asp Glu Ile Val Pro Val Asp Ile Pro Gln Arg Lys Gly 
        195                 200                 205             

Glu Pro Ile Gln Phe Asp Thr Asp Glu Tyr Val Lys Arg Gly Thr Thr 
    210                 215                 220                 

Thr Glu Thr Leu Gly Ala Leu Arg Pro Ala Phe Lys Lys Asp Gly Lys 
225                 230                 235                 240 

Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala Ala Val 
                245                 250                 255     

Val Val Met Ser Lys Glu Lys Ala Val Glu Leu Gly Ile Lys Pro Leu 
            260                 265                 270         

Val Thr Val Arg Ala Asn Ala Thr Ala Gly Val Glu Pro Arg Ile Met 
        275                 280                 285             

Gly Ile Gly Pro Val Pro Ala Thr Lys Lys Ala Leu Thr Lys Ala Gly 
    290                 295                 300                 

Leu Thr Met Asp Asp Ile Asp Leu Ile Glu Ala Asn Glu Ala Phe Ala 
305                 310                 315                 320 

Ala Gln Ser Leu Ala Val Ala Lys Glu Leu Ser Phe Ala Glu Asp Arg 
                325                 330                 335     

Leu Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly Ala 
            340                 345                 350         

Ser Gly Thr Arg Ile Phe Val Thr Leu Leu His Glu Leu Leu Arg Arg 
        355                 360                 365             

Gly Glu Thr Tyr Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln Gly 
    370                 375                 380                 

Val Ala Thr Ile Ile Glu Arg 
385                 390     

<210>   397
<211>   392
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   397
Met Gln Glu Val Val Ile Leu Ser Ala Val Arg Thr Ala Ile Gly Lys 
                5                   10                  15      

Phe Gly Gly Ser Leu Lys Asp Ile Pro Ala Ala Glu Leu Gly Ala Ile 
            20                  25                  30          

Val Ile Lys Glu Ala Leu Val Arg Ala Gln Ile Pro Pro Ala Glu Val 
        35                  40                  45              

Asp Glu Val Ile Phe Gly Asn Val Leu Gln Ala Gly Gln Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Ile Lys Ala Gly Ile Pro Val Asp Ile Pro 
65                  70                  75                  80  

Ala Met Thr Val Asn Met Val Cys Gly Ser Gly Leu Arg Ser Val Ser 
                85                  90                  95      

Leu Ala Ala Thr Leu Ile Ala Ala Gly Glu Ala Asp Leu Ile Val Ala 
            100                 105                 110         

Gly Gly Met Glu Asn Met Ser Ala Ala Pro Tyr Ala Ile Pro Gly Ala 
        115                 120                 125             

Arg Trp Gly Thr Arg Met Gly Asp Gly Lys Ile Val Asp Leu Met Ile 
    130                 135                 140                 

Lys Asp Gly Leu Trp Asp Ala Phe Tyr Asp Tyr His Met Gly Ile Thr 
145                 150                 155                 160 

Ala Glu Asn Leu Ala Glu Arg Tyr Asn Ile Ser Arg Glu Glu Gln Asp 
                165                 170                 175     

Arg Phe Ala Leu Glu Ser Gln Arg Arg Ala Glu Lys Ala Ile Lys Glu 
            180                 185                 190         

Gly Arg Phe Arg Asp Glu Ile Val Pro Val Lys Leu Pro Gln Arg Lys 
        195                 200                 205             

Gly Glu Pro Leu Glu Phe Val Gln Asp Glu Asn Pro Arg Phe Asp Thr 
    210                 215                 220                 

Thr Leu Glu Ala Leu Ala Lys Leu Lys Pro Ala Phe Lys Glu Gly Gly 
225                 230                 235                 240 

Thr Val Thr Ala Gly Asn Ala Ser Ser Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     

Leu Val Ile Ala Ser Ser Lys Lys Ala Glu Ser Leu Gly Ile Lys Pro 
            260                 265                 270         

Met Ala Val Ile Arg Ser Trp Gly Ala Thr Gly Val Asp Pro Ser Ile 
        275                 280                 285             

Met Gly Ile Gly Pro Val Gly Ala Thr Arg Lys Ala Leu Lys Arg Ala 
    290                 295                 300                 

Gly Leu Thr Ile Ala Asp Ile Asp Leu Val Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Ala Lys Glu Leu Glu Leu Asp Leu Ser 
                325                 330                 335     

Lys Thr Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu His Glu Met Lys Lys 
        355                 360                 365             

Ser Asn Ser Arg Tyr Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Met 
    370                 375                 380                 

Gly Val Ala Ala Ile Val Glu Lys 
385                 390         

<210>   398
<211>   391
<212>   PRT
<213>   Desulfitobacterium hafniense DCB-2

<400>   398
Met Gln Asp Val Val Ile Val Ser Ala Val Arg Thr Pro Ile Ala Ser 
                5                   10                  15      

Phe Gly Gly Ala Leu Gln Gly Tyr Gly Ala Val Asn Leu Gly Ala Leu 
            20                  25                  30          

Val Ile Arg Glu Ala Val Gln Arg Ala Gly Ile Gln Gly Lys Gln Val 
        35                  40                  45              

Asp Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Leu Lys Ala Gly Leu Pro Val Glu Thr Thr 
65                  70                  75                  80  

Ala Gln Thr Ile Asn Val Val Cys Gly Ser Gly Leu Lys Ala Val Ile 
                85                  90                  95      

Ala Ala Ala Gln Ala Ile Arg Ala Gly Asp Ala Glu Ile Val Ala Ala 
            100                 105                 110         

Gly Gly Met Glu Ser Met Ser Asp Ala Ala Phe Leu Leu Asp Gln Ala 
        115                 120                 125             

Arg Trp Gly Gln Arg Met Gly His Gly Thr Leu Val Asp Ser Met Ile 
    130                 135                 140                 

Lys Asp Gly Leu Trp Cys Ala Phe Asn Glu Tyr His Met Gly Ile Thr 
145                 150                 155                 160 

Ala Glu Asn Val Ala Glu Lys Tyr Gly Ile Ser Arg Arg Glu Gln Asp 
                165                 170                 175     

Glu Phe Ala Ala Trp Ser Gln Ala Lys Ala Val Ala Ala Met Glu Lys 
            180                 185                 190         

Gly Arg Phe Lys Glu Glu Ile Val Pro Val Ala Ile Pro Gln Arg Lys 
        195                 200                 205             

Gly Glu Pro Val Ile Phe Asp Arg Asp Glu Tyr Pro Arg Ala Gly Thr 
    210                 215                 220                 

Thr Val Glu Thr Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly 
225                 230                 235                 240 

Thr Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Ala Ala Ala Ala 
                245                 250                 255     

Cys Val Leu Met Ser Lys Glu Lys Ala Ala Ala Leu Gly Ile Pro Tyr 
            260                 265                 270         

Leu Ala Ala Ile Lys Gly Tyr Gly Met Ala Gly Val Asp Pro Ala Ile 
        275                 280                 285             

Met Gly Val Gly Pro Val Asn Ala Val Lys Lys Ala Leu Gln Lys Ala 
    290                 295                 300                 

Gly Ile Ala Leu Asp Glu Leu Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Thr Lys Glu Leu Gly Phe Pro Gly Glu 
                325                 330                 335     

Lys Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Thr Arg Ile Leu Val Thr Leu Val His Glu Met Lys Lys 
        355                 360                 365             

Arg Arg Asp Lys Leu Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 

Gly Ile Ala Leu Val Val Glu 
385                 390     

<210>   399
<211>   395
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   399
Met Gln Asp Val Val Ile Ala Gly Ala Val Arg Thr Pro Ile Gly Thr 
                5                   10                  15      

Phe Gln Gly Ser Leu Ser Pro Leu Ser Ala Pro Asp Leu Gly Ala Ala 
            20                  25                  30          

Val Ile Arg Glu Ser Leu Arg Arg Ala Gly Val Glu Ala Gly Ala Val 
        35                  40                  45              

Asp Glu Val Val Met Gly Asn Val Leu Gln Ala Gly Val Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Met Arg Ala Gly Leu Pro Glu Asp Ile Pro 
65                  70                  75                  80  

Ala Thr Thr Val Asn Met Val Cys Gly Ser Gly Leu Lys Ser Val Met 
                85                  90                  95      

Leu Ala Ala Gln Ala Ile Lys Ala Gly Asp Ala Asp Val Leu Val Ala 
            100                 105                 110         

Gly Gly Met Glu Ser Met Ser Asn Ala Pro Tyr Leu Leu Pro Gly Ala 
        115                 120                 125             

Arg Glu Gly Tyr Arg Met Gly His Arg Glu Val Val Asp Ser Met Ile 
    130                 135                 140                 

Arg Asp Gly Leu Trp Cys Ala Phe Cys Asp Ile His Met Gly Val Thr 
145                 150                 155                 160 

Ala Glu Asn Val Ala Asn Arg His Gly Ile Ser Arg Glu Asp Gln Asp 
                165                 170                 175     

Arg Phe Ala Leu Gln Ser Gln Met Arg Ala Lys Glu Ala Met Glu Ala 
            180                 185                 190         

Gly Arg Phe Lys Asp Glu Ile Val Pro Val Ser Val Pro Arg Arg Lys 
        195                 200                 205             

Gly Glu Pro Thr Leu Val Asp Cys Asp Glu His Pro Arg Pro Asp Thr 
    210                 215                 220                 

Thr Tyr Glu Ala Leu Ala Lys Leu Arg Pro Ala Phe Gln Ala Asp Gly 
225                 230                 235                 240 

Thr Val Ile Ala Gly Asn Ser Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     

Met Leu Val Leu Ala Arg Asp Arg Ala Glu Ala Leu Gly Val Lys Pro 
            260                 265                 270         

Met Ala Arg Ile Val Ser Tyr Ala Ser Val Gly Leu Asp Pro Ser Val 
        275                 280                 285             

Met Gly Leu Gly Pro Ile Glu Ala Thr Arg Arg Ala Leu Gly Arg Ala 
    290                 295                 300                 

Gly Leu Ser Val Glu Asp Leu Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Ala Arg Glu Leu Ser Phe Pro Asp Asp 
                325                 330                 335     

Lys Leu Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu Tyr Glu Leu Glu Arg 
        355                 360                 365             

Arg Gly Gly Arg Phe Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 

Gly Val Ala Met Val Val Glu Arg Met Ser Gln 
385                 390                 395 

<210>   400
<211>   395
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   400
Met Gln Asp Val Val Ile Ala Gly Ala Val Arg Thr Pro Ile Gly Thr 
                5                   10                  15      

Phe Gln Gly Ser Leu Ser Pro Leu Ser Ala Pro Asp Leu Gly Ala Ala 
            20                  25                  30          

Val Ile Arg Glu Ser Leu Arg Arg Ala Gly Val Glu Ala Gly Ala Val 
        35                  40                  45              

Asp Glu Val Val Met Gly Asn Val Leu Gln Ala Gly Val Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Met Arg Ala Gly Leu Pro Glu Asp Ile Pro 
65                  70                  75                  80  

Ala Thr Thr Val Asn Met Val Cys Gly Ser Gly Leu Lys Ser Val Met 
                85                  90                  95      

Leu Ala Ala Gln Ala Ile Arg Ala Gly Asp Ala Asp Val Leu Val Ala 
            100                 105                 110         

Gly Gly Met Glu Ser Met Ser Asn Ala Pro Tyr Leu Leu Pro Gly Ala 
        115                 120                 125             

Arg Glu Gly Tyr Arg Met Gly His Arg Glu Val Val Asp Ser Met Ile 
    130                 135                 140                 

Arg Asp Gly Leu Trp Cys Ala Phe Cys Asp Ile His Met Gly Val Thr 
145                 150                 155                 160 

Ala Glu Asn Val Ala Asn Arg His Gly Ile Ser Arg Glu Asp Gln Asp 
                165                 170                 175     

Arg Phe Ala Leu Gln Ser Gln Met Arg Ala Lys Glu Ala Met Glu Ala 
            180                 185                 190         

Gly Arg Phe Lys Asp Glu Ile Val Pro Val Ser Val Pro Arg Arg Lys 
        195                 200                 205             

Gly Glu Pro Thr Leu Val Asp Cys Asp Glu His Pro Arg Pro Asp Thr 
    210                 215                 220                 

Thr Tyr Glu Ala Leu Ala Lys Leu Arg Pro Ala Phe Gln Ala Asp Gly 
225                 230                 235                 240 

Thr Val Ile Ala Gly Asn Ser Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     

Met Leu Val Leu Ala Arg Asp Arg Ala Glu Ala Leu Gly Val Lys Pro 
            260                 265                 270         

Met Ala Arg Ile Val Ser Tyr Ala Ser Val Gly Leu Asp Pro Ser Val 
        275                 280                 285             

Met Gly Leu Gly Pro Ile Glu Ala Thr Arg Arg Ala Leu Gly Arg Ala 
    290                 295                 300                 

Gly Leu Ser Val Glu Asp Leu Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Ala Arg Glu Leu Ser Phe Pro Asp Asp 
                325                 330                 335     

Lys Leu Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu Tyr Glu Leu Glu Arg 
        355                 360                 365             

Arg Gly Gly Arg Phe Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Asn 
    370                 375                 380                 

Gly Val Ala Met Val Val Glu Arg Met Ser Gln 
385                 390                 395 

<210>   401
<211>   395
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   401
Met Gln Asp Val Val Ile Ala Gly Ala Val Arg Thr Pro Ile Gly Thr 
                5                   10                  15      

Phe Gln Gly Ser Leu Ser Pro Leu Ser Ala Pro Asp Leu Gly Ala Ala 
            20                  25                  30          

Val Ile Arg Glu Ser Leu Arg Arg Ala Gly Val Glu Ala Gly Ala Val 
        35                  40                  45              

Asp Glu Val Val Met Gly Asn Val Leu Gln Ala Gly Val Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Met Arg Ala Gly Leu Pro Glu Asp Ile Pro 
65                  70                  75                  80  

Ala Thr Thr Val Asn Met Val Cys Gly Ser Gly Leu Lys Ser Val Met 
                85                  90                  95      

Leu Ala Ala Gln Ala Ile Arg Ala Gly Asp Ala Asp Val Leu Val Ala 
            100                 105                 110         

Gly Gly Met Glu Ser Met Ser Asn Ala Pro Tyr Leu Leu Pro Gly Ala 
        115                 120                 125             

Arg Glu Gly Tyr Arg Met Gly His Arg Glu Val Val Asp Ser Met Ile 
    130                 135                 140                 

Arg Asp Gly Leu Trp Cys Ala Phe Cys Asp Ile His Met Gly Val Thr 
145                 150                 155                 160 

Ala Glu Asn Val Ala Asn Arg His Gly Ile Ser Arg Glu Asp Gln Asp 
                165                 170                 175     

Arg Phe Ala Leu Gln Ser Gln Met Arg Ala Lys Glu Ala Met Glu Ala 
            180                 185                 190         

Gly Arg Phe Lys Asp Glu Ile Val Pro Val Ser Val Pro Arg Arg Lys 
        195                 200                 205             

Gly Glu Pro Thr Leu Val Asp Cys Asp Glu His Pro Arg Pro Asp Thr 
    210                 215                 220                 

Thr Tyr Glu Ala Leu Ala Lys Leu Arg Pro Ala Phe Gln Ala Asp Gly 
225                 230                 235                 240 

Thr Val Ile Ala Gly Asn Ser Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     

Met Leu Val Leu Ala Arg Asp Arg Ala Asp Ala Leu Gly Val Lys Pro 
            260                 265                 270         

Met Ala Arg Ile Val Ser Tyr Ala Ser Val Gly Leu Asp Pro Ser Val 
        275                 280                 285             

Met Gly Leu Gly Pro Ile Glu Ala Thr Arg Arg Ala Leu Gly Arg Ala 
    290                 295                 300                 

Gly Leu Ser Val Glu Asp Leu Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Ala Arg Glu Leu Ser Phe Pro Asp Asp 
                325                 330                 335     

Lys Leu Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu Tyr Glu Leu Glu Arg 
        355                 360                 365             

Arg Gly Gly Arg Phe Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 

Gly Val Ala Met Val Val Glu Arg Met Ser Gln 
385                 390                 395 

<210>   402
<211>   395
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   402
Met Gln Asp Val Val Ile Ala Gly Ala Val Arg Thr Pro Ile Gly Thr 
                5                   10                  15      

Phe Gln Gly Ser Leu Ser Pro Leu Ser Ala Pro Asp Leu Gly Ala Ala 
            20                  25                  30          

Val Ile Arg Glu Ser Leu Arg Arg Ala Gly Val Glu Ala Gly Ala Val 
        35                  40                  45              

Asp Glu Val Val Met Gly Asn Val Leu Gln Ala Gly Val Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Met Arg Ala Gly Leu Pro Glu Asp Ile Pro 
65                  70                  75                  80  

Ala Thr Thr Val Asn Met Val Cys Gly Ser Gly Leu Lys Ser Val Met 
                85                  90                  95      

Leu Ala Ala Gln Ala Ile Arg Ala Gly Asp Ala Asp Val Leu Val Ala 
            100                 105                 110         

Gly Gly Met Glu Ser Met Ser Asn Ala Pro Tyr Leu Leu Pro Gly Ala 
        115                 120                 125             

Arg Glu Gly Tyr Arg Met Gly His Arg Glu Val Val Asp Ser Met Ile 
    130                 135                 140                 

Arg Asp Gly Leu Trp Cys Ala Phe Cys Asp Ile His Met Gly Val Thr 
145                 150                 155                 160 

Ala Glu Asn Val Ala Asn Arg His Gly Ile Ser Arg Glu Asp Gln Asp 
                165                 170                 175     

Arg Phe Ala Leu Gln Ser Gln Met Arg Ala Lys Glu Ala Met Glu Ala 
            180                 185                 190         

Gly Arg Phe Lys Asp Glu Ile Val Pro Val Ser Val Pro Arg Arg Lys 
        195                 200                 205             

Gly Glu Pro Thr Leu Val Asp Cys Asp Glu His Pro Arg Pro Asp Thr 
    210                 215                 220                 

Thr Tyr Glu Ala Leu Ala Lys Leu Arg Pro Ala Phe Gln Ala Asp Gly 
225                 230                 235                 240 

Thr Val Ile Ala Gly Asn Ser Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     

Met Leu Val Leu Ala Arg Asp Arg Ala Glu Ala Leu Gly Val Lys Pro 
            260                 265                 270         

Met Ala Arg Ile Val Ser Tyr Ala Ser Val Gly Leu Asp Pro Ser Val 
        275                 280                 285             

Met Gly Leu Gly Pro Ile Glu Ala Thr Arg Arg Ala Leu Gly Arg Ala 
    290                 295                 300                 

Gly Leu Ser Val Glu Asp Leu Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Ala Arg Glu Leu Ser Phe Pro Glu Asp 
                325                 330                 335     

Lys Leu Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu Tyr Glu Leu Glu Arg 
        355                 360                 365             

Arg Gly Gly Arg Phe Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 

Gly Val Ala Met Val Val Glu Arg Met Ser Gln 
385                 390                 395 

<210>   403
<211>   395
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   403
Met Gln Asp Val Val Ile Ala Gly Ala Val Arg Thr Pro Ile Gly Thr 
                5                   10                  15      

Phe Gln Gly Ser Leu Ser Pro Leu Ser Ala Pro Asp Leu Gly Ala Ala 
            20                  25                  30          

Val Ile Arg Glu Ser Leu Arg Arg Ala Gly Val Glu Ala Gly Ala Val 
        35                  40                  45              

Asp Glu Val Val Met Gly Asn Val Leu Gln Ala Gly Val Gly Gln Asn 
    50                  55                  60                  

Pro Ala Arg Gln Ala Ala Met Arg Ala Gly Leu Pro Glu Asp Ile Pro 
65                  70                  75                  80  

Ala Thr Thr Val Asn Met Val Cys Gly Ser Gly Leu Lys Ser Val Met 
                85                  90                  95      

Leu Ala Ala Gln Ala Ile Arg Ala Gly Asp Ala Asp Val Leu Val Ala 
            100                 105                 110         

Gly Gly Met Glu Ser Met Ser Asn Ala Pro Tyr Leu Leu Pro Gly Ala 
        115                 120                 125             

Arg Glu Gly Tyr Arg Met Gly His Arg Glu Val Val Asp Ser Met Ile 
    130                 135                 140                 

Lys Asp Gly Leu Trp Cys Ala Phe Cys Asp Ile His Met Gly Val Thr 
145                 150                 155                 160 

Ala Glu Asn Val Ala Asn Arg His Gly Ile Ser Arg Glu Asp Gln Asp 
                165                 170                 175     

Arg Phe Ala Leu Gln Ser Gln Met Arg Ala Lys Glu Ala Met Glu Ala 
            180                 185                 190         

Gly Arg Phe Lys Asp Glu Ile Val Pro Val Ser Val Pro Arg Arg Lys 
        195                 200                 205             

Gly Glu Pro Thr Leu Val Asp Cys Asp Glu His Pro Arg Pro Asp Thr 
    210                 215                 220                 

Thr Tyr Glu Ala Leu Ala Lys Leu Arg Pro Ala Phe Gln Ala Asp Gly 
225                 230                 235                 240 

Thr Val Ile Ala Gly Asn Ser Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     

Met Leu Val Leu Ala Arg Asp Arg Ala Glu Ala Leu Gly Val Lys Pro 
            260                 265                 270         

Met Ala Arg Ile Val Ser Tyr Ala Ser Val Gly Leu Asp Pro Ser Val 
        275                 280                 285             

Met Gly Leu Gly Pro Ile Glu Ala Thr Arg Arg Ala Leu Gly Arg Ala 
    290                 295                 300                 

Gly Leu Ser Val Glu Asp Leu Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 

Ala Ala Gln Ala Leu Ala Val Ala Arg Glu Leu Ser Phe Pro Asp Asp 
                325                 330                 335     

Lys Leu Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         

Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu Tyr Glu Leu Glu Arg 
        355                 360                 365             

Arg Gly Gly Arg Phe Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 

Gly Val Ala Met Val Val Glu Arg Met Ser Gln 
385                 390                 395 

<210>   404
<211>   1188
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   404
gtgcaagacg tggtgattgc aggggcagtg cggacgccca tcggaacgtt ccagggaagt       60

ctctcgcccc tttcggcgcc ggatctcggt gcggccgtga tccgggagtc gctgcggcgc      120

gcgggagttg aggccggggc cgtggacgaa gtcgtgatgg gcaacgtgct gcaggcgggc      180

gtcggccaga atccagcgcg gcaagcggcg atgcgcgcgg ggctgccgga agacatcccg      240

gcgacgacgg tgaacatggt gtgcggatcg ggcctaaagt cggtcatgct cgcggcgcag      300

gccattaaag ccggggacgc ggacgtcttg gtggcgggcg gcatggagtc gatgtcgaac      360

gcgccgtacc tgcttccagg ggcgcgcgag ggctaccgca tgggccatcg cgaagtggtc      420

gacagcatga tccgggatgg cttgtggtgc gcgttttgcg acatccacat gggcgtcact      480

gccgaaaacg tggcgaatcg ccacggcatc agccgcgagg atcaggaccg attcgcgctg      540

cagagccaga tgcgcgccaa ggaagcgatg gaggcaggcc ggttcaagga cgagatcgtg      600

cccgtctccg tgccgcggcg gaagggcgag ccgaccttgg tcgattgcga cgaacatccg      660

cgtcccgaca cgacgtacga ggcgctggcg aagcttcggc ccgcgtttca ggcggacggc      720

accgtgatcg ccggcaacag ctcgggcatc aacgacggcg cggcggccat gctggtgctc      780

gcccgggatc gcgccgaggc gttgggcgtg aagccgatgg cgcggatcgt gagctacgcg      840

agcgtgggct tggatccgag cgtgatgggc ctcggtccca tcgaggcgac gcgccgagcg      900

ctcggccggg cggggctttc cgtggaagac ctcgacctca tcgaggcgaa tgaggcgttc      960

gccgcccagg cgctcgcggt ggctcgggaa ctgtcgttcc cggatgacaa gttgaacgtg     1020

aacggcggcg ccatcgcgct cggccacccc atcggcgcga gcggtgcccg gatcttggtc     1080

acgctgcttt acgagctcga gcgccgcggc ggccgtttcg gcctcgccac actgtgcatc     1140

ggcggcggac agggcgtggc catggtcgtg gagcgcatgt cgcagtga                  1188


<210>   405
<211>   1188
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   405
gtgcaagacg tggtgattgc aggggcagtg cggacgccca tcggaacgtt ccagggaagt       60

ctctcgcccc tttcggcgcc ggatctcggt gcggccgtga tccgggagtc gctgcggcgc      120

gcgggagttg aggccggggc cgtggacgaa gtcgtgatgg gcaacgtgct gcaggcgggc      180

gtcggccaga atccagcgcg gcaagcggcg atgcgcgcgg ggctgccgga agacatcccg      240

gcgacgacgg tgaacatggt gtgcggatcg ggcctaaagt cggtcatgct cgcggcgcag      300

gccattcgcg ccggggacgc ggacgtcttg gtggcgggcg gcatggagtc gatgtcgaac      360

gcgccgtacc tgcttccagg ggcgcgcgag ggctaccgca tgggccatcg cgaagtggtc      420

gacagcatga tccgggatgg cttgtggtgc gcgttttgcg acatccacat gggcgtcact      480

gccgaaaacg tggcgaatcg ccacggcatc agccgcgagg atcaggaccg attcgcgctg      540

cagagccaga tgcgcgccaa ggaagcgatg gaggcaggcc ggttcaagga cgagatcgtg      600

cccgtctccg tgccgcggcg gaagggcgag ccgaccttgg tcgattgcga cgaacatccg      660

cgtcccgaca cgacgtacga ggcgctggcg aagcttcggc ccgcgtttca ggcggacggc      720

accgtgatcg ccggcaacag ctcgggcatc aacgacggcg cggcggccat gctggtgctc      780

gcccgggatc gcgccgaggc gttgggcgtg aagccgatgg cgcggatcgt gagctacgcg      840

agcgtgggct tggatccgag cgtgatgggc ctcggtccca tcgaggcgac gcgccgagcg      900

ctcggccggg cggggctttc cgtggaagac ctcgacctca tcgaggcgaa tgaggcgttc      960

gccgcccagg cgctcgcggt ggctcgggaa ctgtcgttcc cggatgacaa gttgaacgtg     1020

aacggcggcg ccatcgcgct cggccacccc atcggcgcga gcggtgcccg gatcttggtc     1080

acgctgcttt acgagctcga gcgccgcggc ggccgtttcg gcctcgccac actgtgcatc     1140

ggcggcggaa atggcgtggc catggtcgtg gagcgcatgt cgcagtga                  1188


<210>   406
<211>   1188
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   406
gtgcaagacg tggtgattgc aggggcagtg cggacgccca tcggaacgtt ccagggaagt       60

ctctcgcccc tttcggcgcc ggatctcggt gcggccgtga tccgggagtc gctgcggcgc      120

gcgggagttg aggccggggc cgtggacgaa gtcgtgatgg gcaacgtgct gcaggcgggc      180

gtcggccaga atccagcgcg gcaagcggcg atgcgcgcgg ggctgccgga agacatcccg      240

gcgacgacgg tgaacatggt gtgcggatcg ggcctaaagt cggtcatgct cgcggcgcag      300

gccattcgcg ccggggacgc ggacgtcttg gtggcgggcg gcatggagtc gatgtcgaac      360

gcgccgtacc tgcttccagg ggcgcgcgag ggctaccgca tgggccatcg cgaagtggtc      420

gacagcatga tccgggatgg cttgtggtgc gcgttttgcg acatccacat gggcgtcact      480

gccgaaaacg tggcgaatcg ccacggcatc agccgcgagg atcaggaccg attcgcgctg      540

cagagccaga tgcgcgccaa ggaagcgatg gaggcaggcc ggttcaagga cgagatcgtg      600

cccgtctccg tgccgcggcg gaagggcgag ccgaccttgg tcgattgcga cgaacatccg      660

cgtcccgaca cgacgtacga ggcgctggcg aagcttcggc ccgcgtttca ggcggacggc      720

accgtgatcg ccggcaacag ctcgggcatc aacgacggcg cggcggccat gctggtgctc      780

gcccgggatc gcgccgatgc gttgggcgtg aagccgatgg cgcggatcgt gagctacgcg      840

agcgtgggct tggatccgag cgtgatgggc ctcggtccca tcgaggcgac gcgccgagcg      900

ctcggccggg cggggctttc cgtggaagac ctcgacctca tcgaggcgaa tgaggcgttc      960

gccgcccagg cgctcgcggt ggctcgggaa ctgtcgttcc cggatgacaa gttgaacgtg     1020

aacggcggcg ccatcgcgct cggccacccc atcggcgcga gcggtgcccg gatcttggtc     1080

acgctgcttt acgagctcga gcgccgcggc ggccgtttcg gcctcgccac actgtgcatc     1140

ggcggcggac agggcgtggc catggtcgtg gagcgcatgt cgcagtga                  1188


<210>   407
<211>   1188
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   407
gtgcaagacg tggtgattgc aggggcagtg cggacgccca tcggaacgtt ccagggaagt       60

ctctcgcccc tttcggcgcc ggatctcggt gcggccgtga tccgggagtc gctgcggcgc      120

gcgggagttg aggccggggc cgtggacgaa gtcgtgatgg gcaacgtgct gcaggcgggc      180

gtcggccaga atccagcgcg gcaagcggcg atgcgcgcgg ggctgccgga agacatcccg      240

gcgacgacgg tgaacatggt gtgcggatcg ggcctaaagt cggtcatgct cgcggcgcag      300

gccattcgcg ccggggacgc ggacgtcttg gtggcgggcg gcatggagtc gatgtcgaac      360

gcgccgtacc tgcttccagg ggcgcgcgag ggctaccgca tgggccatcg cgaagtggtc      420

gacagcatga tccgggatgg cttgtggtgc gcgttttgcg acatccacat gggcgtcact      480

gccgaaaacg tggcgaatcg ccacggcatc agccgcgagg atcaggaccg attcgcgctg      540

cagagccaga tgcgcgccaa ggaagcgatg gaggcaggcc ggttcaagga cgagatcgtg      600

cccgtctccg tgccgcggcg gaagggcgag ccgaccttgg tcgattgcga cgaacatccg      660

cgtcccgaca cgacgtacga ggcgctggcg aagcttcggc ccgcgtttca ggcggacggc      720

accgtgatcg ccggcaacag ctcgggcatc aacgacggcg cggcggccat gctggtgctc      780

gcccgggatc gcgccgaggc gttgggcgtg aagccgatgg cgcggatcgt gagctacgcg      840

agcgtgggct tggatccgag cgtgatgggc ctcggtccca tcgaggcgac gcgccgagcg      900

ctcggccggg cggggctttc cgtggaagac ctcgacctca tcgaggcgaa tgaggcgttc      960

gccgcccagg cgctcgcggt ggctcgggaa ctgtcgttcc cggaagacaa gttgaacgtg     1020

aacggcggcg ccatcgcgct cggccacccc atcggcgcga gcggtgcccg gatcttggtc     1080

acgctgcttt acgagctcga gcgccgcggc ggccgtttcg gcctcgccac actgtgcatc     1140

ggcggcggac agggcgtggc catggtcgtg gagcgcatgt cgcagtga                  1188


<210>   408
<211>   1188
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   408
gtgcaagacg tggtgattgc aggggcagtg cggacgccca tcggaacgtt ccagggaagt       60

ctctcgcccc tttcggcgcc ggatctcggt gcggccgtga tccgggagtc gctgcggcgc      120

gcgggagttg aggccggggc cgtggacgaa gtcgtgatgg gcaacgtgct gcaggcgggc      180

gtcggccaga atccagcgcg gcaagcggcg atgcgcgcgg ggctgccgga agacatcccg      240

gcgacgacgg tgaacatggt gtgcggatcg ggcctaaagt cggtcatgct cgcggcgcag      300

gccattcgcg ccggggacgc ggacgtcttg gtggcgggcg gcatggagtc gatgtcgaac      360

gcgccgtacc tgcttccagg ggcgcgcgag ggctaccgca tgggccatcg cgaagtggtc      420

gacagcatga tcaaagatgg cttgtggtgc gcgttttgcg acatccacat gggcgtcact      480

gccgaaaacg tggcgaatcg ccacggcatc agccgcgagg atcaggaccg attcgcgctg      540

cagagccaga tgcgcgccaa ggaagcgatg gaggcaggcc ggttcaagga cgagatcgtg      600

cccgtctccg tgccgcggcg gaagggcgag ccgaccttgg tcgattgcga cgaacatccg      660

cgtcccgaca cgacgtacga ggcgctggcg aagcttcggc ccgcgtttca ggcggacggc      720

accgtgatcg ccggcaacag ctcgggcatc aacgacggcg cggcggccat gctggtgctc      780

gcccgggatc gcgccgaggc gttgggcgtg aagccgatgg cgcggatcgt gagctacgcg      840

agcgtgggct tggatccgag cgtgatgggc ctcggtccca tcgaggcgac gcgccgagcg      900

ctcggccggg cggggctttc cgtggaagac ctcgacctca tcgaggcgaa tgaggcgttc      960

gccgcccagg cgctcgcggt ggctcgggaa ctgtcgttcc cggatgacaa gttgaacgtg     1020

aacggcggcg ccatcgcgct cggccacccc atcggcgcga gcggtgcccg gatcttggtc     1080

acgctgcttt acgagctcga gcgccgcggc ggccgtttcg gcctcgccac actgtgcatc     1140

ggcggcggac agggcgtggc catggtcgtg gagcgcatgt cgcagtga                  1188


<210>   409
<211>   662
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   409
Met Arg Arg Asp Pro Arg Gly Arg Arg Ser Val Glu His Asp Arg Glu 
                5                   10                  15      

Arg Pro Ala His Pro Ala Thr Gly Gly Leu Arg Gly Pro Val Leu Ser 
            20                  25                  30          

Leu Glu Leu Arg Arg Val Pro Arg Glu Ile Ser Ser Val His Arg Arg 
        35                  40                  45              

Ser Gly Gly Ile Leu Gly Arg Asp Arg Arg Arg Val Gly Met Ala Ala 
    50                  55                  60                  

Ala Arg Lys Asp Gly His Arg Gly Arg Ala Ser Arg Phe Ser Val Leu 
65                  70                  75                  80  

Ser Arg Lys Leu His Gln Arg Val Arg Lys Leu Arg Gly Ser Thr Ser 
                85                  90                  95      

Gln Ala Pro Asp Val Arg Asn Lys Val Ala Leu Phe Phe Glu Gly Glu 
            100                 105                 110         

Asp Gly Glu Arg Arg Ser Val Thr Tyr Leu Gln Leu Gln Asp Ala Val 
        115                 120                 125             

Ser Arg Phe Ala Asn Ala Leu Lys Asp Leu Gly Leu Arg Gln Gly Asp 
    130                 135                 140                 

Val Val Cys Val Tyr Met Gln Asn Leu Ile Glu Thr Tyr Val Ala Leu 
145                 150                 155                 160 

Leu Ala Cys Leu Arg Ile Gly Val Leu Tyr Asn Thr Val Phe Ala Gly 
                165                 170                 175     

Phe Ser Ala Glu Ala Leu Arg Glu Arg Ile Val Arg Cys Gly Ala Lys 
            180                 185                 190         

Ala Val Ile Cys Ala Asn Gly Ser Leu Arg Arg Gly Arg Val Leu Arg 
        195                 200                 205             

Leu Lys Glu Thr Val Asp Arg Ala Leu Glu Gly Val Glu Thr Val Glu 
    210                 215                 220                 

His Val Ile Val Tyr Arg Arg Leu Pro Asp Leu Asp Thr Pro Met Thr 
225                 230                 235                 240 

Pro Gly Arg Asp Leu Asp Phe Glu Ser Leu Val Glu Arg Ala Ser Arg 
                245                 250                 255     

Asp Cys Pro Pro Ala Val Leu Glu Ala Asn Glu Pro Ala Phe Leu Ile 
            260                 265                 270         

Phe Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ile Val His Ala Gly 
        275                 280                 285             

Gly Gly Phe Leu Leu Gly Thr Tyr Ala Tyr Thr Lys Tyr Gln Leu Asp 
    290                 295                 300                 

Leu Arg Pro Glu Asp Val Tyr Trp Asn Thr Ala Asp Ile Gly Trp Leu 
305                 310                 315                 320 

Thr Ser His Ile Phe Val Leu Val Gly Gly Leu Ala Leu Gly Thr Thr 
                325                 330                 335     

Thr Ile Leu Tyr Glu Gly Ala Leu Asp Trp Pro Lys Ser Gly Arg Leu 
            340                 345                 350         

Tyr Glu Met Ile Glu Arg Tyr Arg Val Asn Lys Leu Phe Ser Ala Pro 
        355                 360                 365             

Thr Ala Tyr Arg Met Met Met Lys His Gly Glu Asp Ile Ala Arg Gln 
    370                 375                 380                 

Tyr Asp Leu Ser Ser Leu Glu Leu Leu Val Ser Val Gly Glu Pro Phe 
385                 390                 395                 400 

Asn Pro Glu Ala Trp His Trp Val Arg Arg Val Val Gly Gly Asp Val 
                405                 410                 415     

Ala Val Ile Asn Asn Thr Trp Gly Gln Thr Glu Thr Gly Gly Thr Pro 
            420                 425                 430         

Leu Ala Leu Leu Pro Gly Ala Val Pro Met Lys Pro Gly Ser Cys Gly 
        435                 440                 445             

Val Pro Phe Phe Gly His Asp Leu Ala Val Val Asp Glu Gln Gly Arg 
    450                 455                 460                 

Glu Val Pro Asp Gly Val Pro Gly Tyr Leu Val Ile Arg Arg Pro Phe 
465                 470                 475                 480 

Pro Ser Leu Ala Arg Asp Val Tyr Gly Asp Arg Asn Leu Tyr Leu Asn 
                485                 490                 495     

Ala Tyr Phe Ser Arg Met Pro Gly Leu Tyr Phe Thr Gly Asp Ser Ala 
            500                 505                 510         

Val Arg Asp Ala Asp Gly His Phe Trp Val Leu Gly Arg Val Asp Asp 
        515                 520                 525             

Val Ile Asn Val Ser Gly His Arg Ile Ser Thr Met Glu Met Glu Ser 
    530                 535                 540                 

Ser Leu Ile Gln His Pro Ala Val Val Glu Ala Ala Val Val Gly Glu 
545                 550                 555                 560 

Pro Asp Asp Val Lys Gly Gln Val Pro Val Ala Phe Val Thr Leu Glu 
                565                 570                 575     

Arg Gly Trp Glu Pro Ser Thr Asp Leu Glu Glu Glu Leu Lys Ala Arg 
            580                 585                 590         

Val Val Ala Asp Ile Gly Ser Phe Ala Arg Pro Ala Arg Val Tyr Phe 
        595                 600                 605             

Val Glu Ala Met Pro Lys Thr Arg Ser Gly Lys Ile Leu Arg Arg Met 
    610                 615                 620                 

Leu Arg Glu Ile Leu Gln Thr Gly Glu Val Lys Gly Asp Val Thr Gly 
625                 630                 635                 640 

Leu Glu Asp Trp Glu Val Val Glu Arg Leu Leu His Asp Leu Arg Glu 
                645                 650                 655     

Arg Ala Pro Gly Gly Glu 
            660         

<210>   410
<211>   1989
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   410
ttgaggaggg atcctcgtgg cagacgaagt gttgagcatg atcgcgagcg cccggctcat       60

cccgccaccg gaggcctacg cggcccggtc ttatctctcg agctacgacg agtaccgcgc      120

gagatatcaa gcgtccatcg acgatccggc ggcattctgg gacgagatcg ccgacgagtt      180

ggtatggcag cagcgcggaa agacggtcat cgcgggcgag cttcccgatt ttcagttctt      240

tcccggaagt tacatcaacg tgtgcgaaaa ctgcgtggat cgacaagcca agcacccgat      300

gtacgcaaca aggtggcgct cttcttcgag ggggaggacg gcgaacgccg cagcgtgacg      360

tacctccagc tccaggatgc cgtgtcccgg tttgcgaacg cgctcaaaga tctcgggctg      420

cgacagggcg atgtggtctg cgtgtacatg caaaatctca tcgagaccta cgtcgcgctc      480

ttggcgtgcc tgcgcatcgg cgtgctctac aacacggtgt ttgcgggatt ttccgccgag      540

gcgctgcgcg agcggattgt gcggtgcggg gccaaggcgg tgatctgcgc caacggaagt      600

ctcaggcgcg gccgggtgct tcggctgaag gaaaccgtcg accgggcgct tgaaggtgtg      660

gagaccgtgg agcacgtcat cgtctaccgg cgcctgcccg atctcgacac gccgatgacg      720

ccggggcgcg atctcgactt tgagtcgctc gtcgagcgcg cctcccggga ctgccctcct      780

gctgtactgg aggcgaacga gcccgccttc ctcatcttca cgagcggaac gacgggccgg      840

ccgaaaggca tcgtccacgc cggcggcgga tttctgcttg gaacctacgc gtacacgaag      900

taccagctcg acctccggcc cgaggacgtg tactggaaca cagcggacat cggctggctc      960

acatctcaca tcttcgtgct ggtcggcggt ctcgccttag gcaccacgac catcctgtac     1020

gagggcgcgc tggattggcc caaatcgggc aggctatacg agatgatcga gcgataccgc     1080

gtcaacaaac tgttctcggc acccaccgcc tatcggatga tgatgaaaca cggcgaggac     1140

atcgcgcggc aatacgactt gtcgtcgctt gaactcttgg tgtcggtcgg agagccgttc     1200

aatcccgagg cgtggcattg ggtccgccgc gttgtcggcg gtgacgtcgc tgtcatcaac     1260

aacacctggg gccagaccga gaccggtgga acgccgctcg cgctgttgcc aggggcggtg     1320

cccatgaaac ccggctcgtg tggcgtgccg ttcttcggac acgatctcgc cgtcgtggat     1380

gaacagggcc gggaggtgcc ggacggggtg cccggatatc tcgtgatccg ccgtccgttc     1440

ccgtcgctcg cgcgcgacgt gtacggcgat cggaacctgt acctgaacgc gtacttctcg     1500

cgtatgcccg ggctctactt cacgggcgac agcgcggtcc gggatgcgga tggccacttc     1560

tgggtgctcg gccgggtcga cgacgtgatc aacgtgtcgg gccaccgaat cagcacgatg     1620

gagatggaga gctcgctcat ccagcatccg gccgtggtgg aggcggcggt cgtgggcgag     1680

cctgacgacg tgaagggcca ggtccccgtt gcgttcgtga cgctcgagcg cgggtgggaa     1740

ccgagcacgg acctggagga ggaactgaag gcgcgcgtcg tggcggacat cggttcgttt     1800

gcgcggccgg cgcgcgtgta cttcgtggag gcgatgccga agacgcgatc gggcaagatc     1860

ctgcggcgga tgctgcgcga gatcctgcag acgggcgaag tgaaagggga cgtcaccggc     1920

ctggaggact gggaggtcgt ggaacggctt ctgcacgatt tgcgcgagcg ggcgccgggc     1980

ggtgaatga                                                             1989


<210>   411
<211>   552
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   411
Arg Asn Lys Ala Ala Leu Leu Trp Glu Ser Glu Asp Gly Arg Arg Glu 
                5                   10                  15      

Val Trp Thr Tyr Gln Gln Leu Ala Asp Glu Val Asn Arg Phe Ala Asn 
            20                  25                  30          

Val Leu Arg Glu Leu Gly Val Gly Arg Gly Asp Val Val Ala Ile Tyr 
        35                  40                  45              

Met Gly Asn Ile Pro Glu Val Phe Val Ser Val His Ala Cys Tyr Arg 
    50                  55                  60                  

Ile Gly Ala Leu Tyr Ser Ile Ile Phe Ala Gly Phe Ser Thr Asp Ala 
65                  70                  75                  80  

Val Arg Gln Arg Leu Glu Asp Ala Arg Pro Lys Val Val Val Val Ala 
                85                  90                  95      

Asp Ala Thr Ser Arg Arg Gly Arg Glu Val Pro Leu Lys Arg Thr Leu 
            100                 105                 110         

Asp Gln Ala Leu Ala Gly Ile Asp Ser Val Glu Thr Val Val Val Val 
        115                 120                 125             

Pro Arg Ala Gly Ala Glu Thr Glu Leu Arg Glu Gly Arg Asp Arg Leu 
    130                 135                 140                 

Tyr Gly Asp Leu Val Ser Arg Ala Gly Ala Trp Cys Pro Pro Glu Pro 
145                 150                 155                 160 

Met Glu Ala Asn Glu Pro Gly Phe Ile Ile Tyr Thr Ser Gly Thr Glu 
                165                 170                 175     

Ser Arg Pro Lys Gly Leu Val His Ala Gly Leu Gly Phe Leu Val Gly 
            180                 185                 190         

Thr Tyr Ala Asp Val Lys Trp Ser Met Asn Pro Gln Asp Asp Asp Val 
        195                 200                 205             

Tyr Trp Cys Thr Ala Asp Val Gly Trp Leu Thr Phe Pro Ile Trp Ser 
    210                 215                 220                 

Leu Val Gly Gly Leu Ala His Gly Thr Thr Met Val Val Tyr Glu Gly 
225                 230                 235                 240 

Ala Leu Asn His Pro Asp Pro Gly Arg Phe Tyr Glu Ile Leu Glu Arg 
                245                 250                 255     

Tyr Arg Val Asn Lys Val Phe Thr Ala Pro Thr Ala Leu Arg Met Leu 
            260                 265                 270         

Arg Gly Ala Gly Glu Arg Trp Leu Glu Gly Arg Asp Leu Ser Ala Leu 
        275                 280                 285             

Lys Leu Val Ser Leu Val Gly Glu Pro Ile Asp Pro Glu Thr Trp His 
    290                 295                 300                 

Trp Val Arg Glu Val Val Gly Arg Gly Glu Ala Phe Val Asn Asn Thr 
305                 310                 315                 320 

Tyr Gly Gln Thr Glu Thr Ala Thr Gly Trp Thr Ser Ala Ile Val Gly 
                325                 330                 335     

Leu Thr Gly Ala Lys Pro Gly Ser Cys Gly Ile Pro Leu Pro Gly Tyr 
            340                 345                 350         

Val Ser Glu Val Val Asp Glu Gly Gly Arg Pro Val Pro Pro Gly Thr 
        355                 360                 365             

Pro Gly Tyr Leu Thr Ile Thr Glu Pro Phe Pro Cys Leu Ala Arg Thr 
    370                 375                 380                 

Val Trp Gly Asp His Gln Arg Tyr Leu Ser Thr Tyr Phe Glu Arg Phe 
385                 390                 395                 400 

Pro Gly Arg Tyr Phe Ser Ala Asp Ala Cys Val Val Asp Arg Asp Gly 
                405                 410                 415     

His Tyr Trp Val Thr Gly Arg Val Asp Asp Val Ile Asn Val Ala Gly 
            420                 425                 430         

His Arg Leu Gly Thr Met Glu Met Glu Ser Ala Leu Leu Asn His Pro 
        435                 440                 445             

Asp Val Ala Glu Ala Ala Val Ile Gly Val Pro Asp Ala Thr Lys Gly 
    450                 455                 460                 

Thr Val Pro Val Ala Phe Ala Leu Leu Arg Ala Gly Ala Glu Pro Arg 
465                 470                 475                 480 

Pro Gly Leu Arg Glu Glu Leu Glu Gln Arg Ile Val Glu Arg Val Gly 
                485                 490                 495     

Ser Ile Ala Arg Pro Ala Ala Val His Ile Val Ser Ala Leu Pro Lys 
            500                 505                 510         

Thr Arg Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Glu Leu Val Thr 
        515                 520                 525             

Glu Gly Arg Val Arg Gly Asp Thr Thr Ala Leu Glu Asp Pro Glu Ser 
    530                 535                 540                 

Val Ser Val Leu Glu Lys Glu Leu 
545                 550         

<210>   412
<211>   559
<212>   PRT
<213>   Deinococcus radiodurans R1

<400>   412
Lys Asn Arg Val Ala Leu Tyr Tyr Glu Arg Glu Asp Gly Leu Lys Glu 
                5                   10                  15      

Thr Trp Ser Tyr Gly Asp Leu Thr Asp Ala Thr Ala Arg Phe Ala Ala 
            20                  25                  30          

Ala Leu Gln Asp Leu Gly Val Asp Lys Gly Asp Arg Val Ala Ile Tyr 
        35                  40                  45              

Leu Ser Asn Val Pro Glu Ala Phe Ile Ala Ile His Ala Cys Tyr Arg 
    50                  55                  60                  

Ile Gly Ala Ile Tyr Ser Val Ile Phe Ala Gly Phe Ser Ala Ser Ala 
65                  70                  75                  80  

Val Arg Asp Arg Leu Thr Asp Ala Gln Pro Lys Val Val Val Cys Thr 
                85                  90                  95      

Asp Gly Thr Leu Arg Arg Gly Arg Asn Ile Pro Leu Lys Ala Thr Leu 
            100                 105                 110         

Asp Glu Ala Leu Glu Gly Leu Glu Lys Pro Thr Val Ile Val Ala Arg 
        115                 120                 125             

Arg Leu Asp Pro Phe Leu Pro Leu Gly Glu Asn Glu Leu Asp Phe Ala 
    130                 135                 140                 

Glu Leu Leu Glu Lys Thr Thr Arg Arg Ala Ala Pro Val Ser Leu Asp 
145                 150                 155                 160 

Ala Asn Asp Pro Gly Phe Ile Ile Tyr Thr Ser Gly Thr Thr Ser Lys 
                165                 170                 175     

Pro Lys Gly Leu Val His Ser Gly Ile Gly Phe Leu Thr Gly Thr Tyr 
            180                 185                 190         

Ala Asn Val Lys Trp Ala Leu Asn Leu Gln Pro Asp Asp Val Tyr Trp 
        195                 200                 205             

Cys Thr Ala Asp Val Gly Trp Leu Thr Phe Pro Ile Phe Ala Leu Val 
    210                 215                 220                 

Gly Gly Leu Ala His Gly Ala Thr His Val Ile Tyr Glu Gly Ser Ile 
225                 230                 235                 240 

Asp Thr Pro Thr Pro Glu Arg Pro Tyr Gln Ile Ile Glu Arg Tyr Arg 
                245                 250                 255     

Ala Asp Lys Val Phe Thr Ala Pro Thr Ala Leu Arg Met Leu Arg Arg 
            260                 265                 270         

Ser Gly Asp Glu Ala Leu Ala Arg Tyr Asp Leu Ser Pro Leu Gln Leu 
        275                 280                 285             

Val Ala Leu Val Gly Glu Pro Leu Asp Pro Glu Thr Trp His Trp Thr 
    290                 295                 300                 

His Asp Val Leu Gly Gly Gly Arg Leu Phe Val Asn Asn Thr Tyr Gly 
305                 310                 315                 320 

Gln Thr Glu Thr Gly Thr Ala Trp Ala Ser Ser Met Val Gly Leu Thr 
                325                 330                 335     

Glu Gly Arg Pro Gly Ser Cys Gly His Pro Leu Pro Gly Tyr Arg Ala 
            340                 345                 350         

Ala Val Val His Glu Asp Gly Thr Pro Cys Gly Pro Asn Glu Leu Gly 
        355                 360                 365             

Ser Leu Thr Leu Thr Glu Pro Phe Pro Cys Leu Ala Arg Thr Val Trp 
    370                 375                 380                 

Gly Asp His Asp Arg Tyr Val Glu Thr Tyr Leu Ser Glu Phe Pro Gly 
385                 390                 395                 400 

Lys Tyr Ala Ala Ala Asp Ala Ala Leu Leu Asp Ser Asp Gly Gln Leu 
                405                 410                 415     

Trp Val Thr Gly Arg Leu Asp Asp Val Met Asn Val Ala Gly His Arg 
            420                 425                 430         

Leu Gly Thr Met Glu Met Glu Ala Ala Leu Leu Thr His Pro Ala Val 
        435                 440                 445             

Ser Glu Ala Ala Val Val Ala Met Pro Asp Asp Ile Lys Gly Ala Val 
    450                 455                 460                 

Pro Val Ala Phe Val Val Pro Arg Ala Gly Ile Arg Leu Asp Thr Asp 
465                 470                 475                 480 

Leu Thr Trp Leu Glu Asn Glu Leu Ala Asp Ala Val Val Ser Gly Val 
                485                 490                 495     

Gly Ala Ile Ala Arg Pro Gly Arg Val Val Val Thr Pro Thr Val Pro 
            500                 505                 510         

Arg Thr Arg Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Leu Leu 
        515                 520                 525             

Leu Thr Gly Glu Val Lys Gly Asp Leu Thr Ser Leu Glu Asn Pro Asp 
    530                 535                 540                 

Ala Leu Glu Thr Val Arg Glu Arg Leu Gly Gly Ala Ala Ala Gly 
545                 550                 555                 

<210>   413
<211>   553
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   413
Arg Asn Lys Ala Ala Leu Ile Phe Glu Gly Glu Pro Gly Asp Ser Lys 
                5                   10                  15      

Ile Leu Thr Tyr Gln Glu Leu Tyr Arg Glu Val Asn Lys Phe Ala Asn 
            20                  25                  30          

Val Leu Lys Lys Leu Gly Val Gln Lys Gly Asp Arg Val Thr Ile Tyr 
        35                  40                  45              

Met Pro Met Ile Pro Glu Ala Val Ile Ala Met Leu Ala Cys Thr Arg 
    50                  55                  60                  

Ile Gly Ala Pro His Ser Val Val Phe Gly Gly Phe Ser Ser Gln Ala 
65                  70                  75                  80  

Leu Lys Asp Arg Ile Asp Asp Ala Lys Ala Lys Leu Leu Ile Thr Ala 
                85                  90                  95      

Asp Gly Gly Tyr Arg Arg Gly Ser Ile Val Glu Leu Lys Lys Asn Ala 
            100                 105                 110         

Asp Ala Ala Leu Glu Gly Glu Thr Thr Ile Glu Lys Val Val Val Val 
        115                 120                 125             

Lys Arg Thr Gly Gln Glu Val Pro Met Thr Glu Gly Arg Asp Tyr Trp 
    130                 135                 140                 

Tyr His Glu Leu Met Ala Asp Ala Ala Leu Tyr Cys Glu Pro Glu Gln 
145                 150                 155                 160 

Cys Asp Ala Glu Asp Met Leu Phe Ile Leu Tyr Ser Ser Gly Thr Thr 
                165                 170                 175     

Gly Lys Pro Lys Gly Ile Gln His Thr Thr Gly Gly Tyr Leu Val Gly 
            180                 185                 190         

Val His Thr Thr Phe Lys Tyr Ile Phe Asp Tyr Arg Glu Glu Asp Ile 
        195                 200                 205             

Tyr Trp Cys Thr Ala Asp Ile Gly Trp Ile Thr Gly His Ser Tyr Ile 
    210                 215                 220                 

Val Tyr Gly Pro Leu Ser Asn Gly Ala Thr Val Val Leu Tyr Glu Gly 
225                 230                 235                 240 

Ala Pro Asp Trp Pro Gln Lys Asp Arg Phe Trp Glu Ile Ile Glu Lys 
                245                 250                 255     

Tyr Arg Val Asn Ile Leu Tyr Thr Ala Pro Thr Ala Ile Arg Thr Phe 
            260                 265                 270         

Met Arg Trp Gly Glu Lys Trp Pro Lys Gly Arg Asp Leu Ser Ser Leu 
        275                 280                 285             

Arg Leu Leu Gly Thr Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Ile 
    290                 295                 300                 

Trp Tyr His Glu His Ile Gly Gly Gly Arg Cys Pro Ile Val Asp Thr 
305                 310                 315                 320 

Trp Trp Gln Thr Glu Thr Gly Met Ile Met Ile Thr Pro Leu Pro Gly 
                325                 330                 335     

Val Ile Pro Thr Lys Pro Gly Ser Ala Thr Lys Pro Phe Pro Gly Val 
            340                 345                 350         

Glu Ala Asp Val Val Asn Asp Lys Gly Glu Pro Val Pro Pro Gly Gln 
        355                 360                 365             

Gly Gly Tyr Leu Val Leu Lys Lys Pro Trp Pro Ala Met Leu Arg Thr 
    370                 375                 380                 

Leu Tyr Gly Asp Pro Glu Arg Tyr Lys Asn Thr Tyr Trp Ser Lys Phe 
385                 390                 395                 400 

Pro Gly Trp Tyr Phe Thr Gly Asp Gly Ala Lys Lys Asp Glu Asp Gly 
                405                 410                 415     

Tyr Phe Trp Ile Leu Gly Arg Val Asp Asp Val Ile Asn Val Ser Gly 
            420                 425                 430         

His Arg Ile Gly Thr Met Glu Val Glu Ser Ala Leu Val Glu His Pro 
        435                 440                 445             

Leu Val Ala Glu Ala Ala Val Ile Gly Lys Ser His Glu Val Lys Gly 
    450                 455                 460                 

Gln Ala Ile Ala Ala Phe Val Thr Leu Lys Glu Gly Val Glu Gly Thr 
465                 470                 475                 480 

Pro Glu Leu Val Gln Glu Leu Lys Gln Phe Val Ala Gln Lys Ile Gly 
                485                 490                 495     

Ala Leu Ala Arg Pro Asp Asp Ile Phe Phe Thr Ala Glu Leu Pro Lys 
            500                 505                 510         

Thr Arg Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Asp Ile Ala Glu 
        515                 520                 525             

Gly Arg Ala Leu Gly Asp Thr Thr Thr Leu Thr Asp Pro Ala Val Ile 
    530                 535                 540                 

Asn Lys Ile Lys Glu Gln Tyr Lys Asp 
545                 550             

<210>   414
<211>   551
<212>   PRT
<213>   Deinococcus geothermalis DSM 11300

<400>   414
Arg Thr Ala Leu Leu Tyr Glu Arg Glu Asp Gly Leu Arg Glu Thr Trp 
                5                   10                  15      

Thr Tyr Gly Glu Leu Thr Asp Ala Thr Ala Arg Phe Ala Ala Ala Leu 
            20                  25                  30          

Gln Asp Leu Gly Val Ala Lys Gly Asp Arg Val Ala Ile Tyr Leu Gly 
        35                  40                  45              

Asn Val Pro Glu Ala Phe Ile Ala Ile His Ala Cys Tyr Arg Ile Gly 
    50                  55                  60                  

Ala Ile Tyr Ser Val Ile Phe Ala Gly Phe Ser Ala Ser Ala Val Arg 
65                  70                  75                  80  

Asp Arg Leu Thr Asp Ala Arg Pro Lys Val Val Ile Cys Thr Asp Ala 
                85                  90                  95      

Thr Leu Arg Arg Gly Lys Val Ile Pro Leu Lys Ala Thr Leu Asp Glu 
            100                 105                 110         

Ala Leu Glu Gly Leu Glu Ile Gly His Val Ile Val Ala Arg Arg Val 
        115                 120                 125             

Asp Arg Glu Ser Ala Leu Arg Gly Gly Glu His Asp Phe His Ala Leu 
    130                 135                 140                 

Leu Asn Ser Thr Ala Arg Arg Ala Asp Pro Val Pro Leu Glu Ala Asn 
145                 150                 155                 160 

Glu Pro Gly Phe Ile Ile Tyr Thr Ser Gly Thr Thr Ser Lys Pro Lys 
                165                 170                 175     

Gly Leu Val His Ala Gly Leu Gly Phe Leu Ala Gly Ala Tyr Ala Asn 
            180                 185                 190         

Val Lys Trp Ala Leu Asn Leu Cys Pro Gln Asp Val Tyr Trp Cys Thr 
        195                 200                 205             

Ala Asp Val Gly Trp Leu Thr Phe Pro Ile Phe Ala Leu Val Gly Gly 
    210                 215                 220                 

Leu Ala His Gly Ala Thr His Val Ile Tyr Glu Gly Ser Ile Asp Thr 
225                 230                 235                 240 

Pro Thr Pro Ala Arg Pro Tyr Glu Ile Ile Glu Arg Tyr Gly Val Asn 
                245                 250                 255     

Lys Val Phe Thr Ala Pro Thr Ala Leu Arg Met Leu Arg Arg Ala Gly 
            260                 265                 270         

Asp Ser Ala Leu Ala Gly His Asp Leu Asn Thr Leu Glu Leu Ile Ala 
        275                 280                 285             

Leu Val Gly Glu Pro Leu Asp Pro Glu Thr Trp His Trp Thr Arg Glu 
    290                 295                 300                 

Arg Leu Gly Ala Gly Arg Ile Phe Val Asn Asn Thr Tyr Gly Gln Thr 
305                 310                 315                 320 

Glu Thr Gly Thr Ala Trp Ala Ser Ser Met Val Gly Leu Thr Pro Thr 
                325                 330                 335     

Arg Pro Gly Ser Cys Gly His Pro Leu Pro Gly Tyr Arg Ala Arg Val 
            340                 345                 350         

Val Arg Glu Asp Gly Gln Ala Ala Ala Pro Gly Glu Leu Gly Ala Leu 
        355                 360                 365             

Thr Leu Thr Glu Pro Phe Pro Cys Leu Ala Arg Thr Val Trp Gly Asp 
    370                 375                 380                 

His Glu Arg Tyr Val Gln Thr Tyr Leu Ala Asp Phe Pro Gly Ser Tyr 
385                 390                 395                 400 

Ala Ala Ser Asp Ala Ala Leu Leu Asp Gly Asp Gly Gln Leu Trp Val 
                405                 410                 415     

Thr Gly Arg Leu Asp Asp Val Met Asn Val Ala Gly His Arg Ile Gly 
            420                 425                 430         

Thr Met Glu Leu Glu Ala Ala Leu Ile Thr His Pro Ala Val Ser Glu 
        435                 440                 445             

Ala Ala Val Val Ala Gln Pro Asp Glu Val Lys Gly Ser Val Pro Val 
    450                 455                 460                 

Ala Phe Val Val Pro Arg Gly Asp Ala Gln Val Gly Pro Gly Leu Glu 
465                 470                 475                 480 

Glu Glu Leu Ala Glu Ala Ile Val Arg Gly Val Gly Pro Ile Ala Arg 
                485                 490                 495     

Pro Ala Arg Val Ile Val Thr Pro Thr Val Pro Arg Thr Arg Ser Gly 
            500                 505                 510         

Lys Ile Met Arg Arg Leu Leu Arg Asp Leu Leu Val Ser Gly Glu Val 
        515                 520                 525             

Arg Gly Asp Leu Thr Ser Leu Glu Asn Pro Asp Ala Ile Glu Val Val 
    530                 535                 540                 

Arg Glu Arg Leu Ala Gly Gly 
545                 550     

<210>   415
<211>   551
<212>   PRT
<213>   Acidobacteria bacterium Ellin345

<400>   415
Arg His Lys Ala Ala Phe Ile Trp Glu Gly Glu Pro Gly Asp Val Arg 
                5                   10                  15      

Thr Leu Thr Tyr Gln Gln Leu Trp Leu Glu Val Gln Lys Phe Ala Asn 
            20                  25                  30          

Val Leu Leu Asp Leu Gly Ile Lys Lys Gly Asp Arg Val Ala Ile Tyr 
        35                  40                  45              

Met Gly Met Val Pro Glu Leu Pro Val Ala Met Leu Ala Cys Ala Arg 
    50                  55                  60                  

Ile Gly Ala Thr His Ser Val Ile Phe Gly Gly Phe Ser Ala Asn Ala 
65                  70                  75                  80  

Leu Val Asp Arg Ile Thr Asp Gln Gln Ala Val Ala Val Ile Thr Gln 
                85                  90                  95      

Asp Gly Ser Trp Arg Arg Gly Asn Glu Val Lys Leu Lys Val Ala Val 
            100                 105                 110         

Asp Glu Ala Leu Glu Lys Cys Pro Thr Val Lys His Val Val Val Tyr 
        115                 120                 125             

Lys Arg Thr Ala Ser Ala Ile Asn Met Lys Glu Gly Arg Asp His Trp 
    130                 135                 140                 

Trp His Asp Leu Met Ala Lys Ala Lys Asp His Cys Pro Ala Glu Pro 
145                 150                 155                 160 

Leu Asp Ala Glu His Pro Leu Tyr Ile Leu Tyr Thr Ser Gly Thr Thr 
                165                 170                 175     

Gly Lys Pro Lys Gly Ile Val His Thr Thr Gly Gly Tyr Ala Val Gly 
            180                 185                 190         

Thr Tyr Tyr Thr Thr Lys Met Val Phe Asp Leu Lys Glu Asp Asp Thr 
        195                 200                 205             

Phe Trp Cys Thr Ala Asp Ile Gly Trp Val Thr Gly His Ser Tyr Ile 
    210                 215                 220                 

Val Tyr Gly Pro Leu Gln Thr Gly Ala Thr Thr Val Met Tyr Glu Gly 
225                 230                 235                 240 

Ala Pro Asn Phe Pro Asp Leu Asp Arg Phe Trp Ala Leu Val Ala Lys 
                245                 250                 255     

His Lys Val Thr Val Phe Tyr Thr Ala Pro Thr Ala Ile Arg Thr Phe 
            260                 265                 270         

Met Lys Trp Gly Ala Glu Tyr Pro Asn Arg His Asp Met Ser Thr Leu 
        275                 280                 285             

Arg Leu Leu Gly Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Met 
    290                 295                 300                 

Trp Tyr Arg Asp Val Ile Gly Lys Asp Arg Cys Pro Ile Val Asp Thr 
305                 310                 315                 320 

Trp Trp Gln Thr Glu Thr Gly Ala Ile Met Ile Ser Pro Leu Pro Gly 
                325                 330                 335     

Ala Ile Ala Thr Lys Pro Gly Ser Ala Thr Lys Pro Leu Pro Gly Ile 
            340                 345                 350         

Ile Ala Glu Val Val Thr Arg Ala Gly Glu Lys Val Pro Leu Gly Ser 
        355                 360                 365             

Gly Gly Phe Leu Val Ile Lys Lys Pro Trp Pro Ser Met Met Arg Thr 
    370                 375                 380                 

Ile Tyr Gly Asp Pro Glu Arg Tyr Lys His Gln Tyr Trp Ser Asp Ile 
385                 390                 395                 400 

Pro Gly Val Tyr Phe Thr Gly Asp Gly Ala Arg Glu Asp Lys Asp Gly 
                405                 410                 415     

Tyr Phe Trp Ile Met Gly Arg Val Asp Asp Val Leu Asn Val Ser Gly 
            420                 425                 430         

His Arg Leu Ser Thr Met Glu Ile Glu Ser Ala Leu Val Ala His Pro 
        435                 440                 445             

Lys Val Ala Glu Ala Ala Val Val Gly Arg Pro Asp Glu Met Lys Gly 
    450                 455                 460                 

Gln Ala Val Ser Ala Phe Val Thr Leu Glu Ser Gly Ser Lys Pro Ser 
465                 470                 475                 480 

Pro Glu Leu Lys Glu Glu Leu Arg Ala Trp Val Ala Lys Glu Ile Gly 
                485                 490                 495     

Ser Met Ala Lys Pro Asp Asp Ile Arg Phe Thr Asp Thr Leu Pro Lys 
            500                 505                 510         

Thr Arg Ser Gly Lys Ile Met Arg Arg Leu Leu Arg Glu Leu Ala Thr 
        515                 520                 525             

Gly Gly Asp Val Lys Gly Asp Thr Thr Thr Leu Glu Asp Phe Thr Val 
    530                 535                 540                 

Ile Ala Lys Leu Lys Glu Asp 
545                 550     

<210>   416
<211>   662
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   416
Met Arg Arg Asp Pro Arg Gly Arg Arg Ser Val Glu His Asp Arg Glu 
                5                   10                  15      

Arg Pro Ala His Pro Ala Thr Gly Gly Leu Arg Gly Pro Val Leu Ser 
            20                  25                  30          

Leu Glu Leu Arg Arg Val Pro Arg Glu Ile Ser Ser Val His Arg Arg 
        35                  40                  45              

Ser Gly Gly Ile Leu Gly Arg Asp Arg Arg Arg Val Gly Met Ala Ala 
    50                  55                  60                  

Ala Arg Lys Asp Gly His Arg Gly Arg Ala Ser Arg Phe Ser Val Leu 
65                  70                  75                  80  

Ser Arg Lys Leu His Gln Arg Val Arg Lys Leu Arg Gly Ser Thr Ser 
                85                  90                  95      

Gln Ala Pro Asp Val Arg Asn Lys Val Ala Leu Phe Phe Glu Gly Glu 
            100                 105                 110         

Asp Gly Glu Arg Arg Ser Val Thr Tyr Leu Gln Leu Gln Asp Ala Val 
        115                 120                 125             

Ser Arg Phe Ala Asn Ala Leu Lys Asp Leu Gly Leu Arg Gln Gly Asp 
    130                 135                 140                 

Val Val Cys Val Tyr Met Gln Asn Leu Ile Glu Thr Tyr Val Ala Leu 
145                 150                 155                 160 

Leu Ala Cys Leu Arg Ile Gly Val Leu Tyr Asn Thr Val Phe Ala Gly 
                165                 170                 175     

Phe Ser Ala Glu Ala Leu Arg Glu Arg Ile Val Arg Cys Gly Ala Lys 
            180                 185                 190         

Ala Val Ile Cys Ala Asn Gly Ser Leu Arg Arg Gly Arg Val Leu Arg 
        195                 200                 205             

Leu Lys Glu Thr Val Asp Arg Ala Leu Glu Gly Val Glu Thr Val Glu 
    210                 215                 220                 

His Val Ile Val Tyr Arg Arg Leu Pro Asp Leu Asp Thr Pro Met Thr 
225                 230                 235                 240 

Pro Gly Arg Asp Leu Asp Phe Glu Ser Leu Val Glu Arg Ala Ser Arg 
                245                 250                 255     

Asp Cys Pro Pro Ala Val Leu Glu Ala Asn Glu Pro Ala Phe Leu Ile 
            260                 265                 270         

Phe Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ile Val His Ala Gly 
        275                 280                 285             

Gly Gly Phe Leu Leu Gly Thr Tyr Ala Tyr Thr Lys Tyr Gln Leu Asp 
    290                 295                 300                 

Leu Arg Pro Glu Asp Val Tyr Trp Asn Thr Ala Asp Ile Gly Trp Leu 
305                 310                 315                 320 

Thr Ser His Ile Phe Val Leu Val Gly Gly Leu Ala Leu Gly Thr Thr 
                325                 330                 335     

Thr Ile Leu Tyr Glu Gly Ala Leu Asp Trp Pro Lys Ser Gly Arg Leu 
            340                 345                 350         

Tyr Glu Met Ile Glu Arg Tyr Arg Val Asn Lys Leu Phe Ser Ala Pro 
        355                 360                 365             

Thr Ala Tyr Arg Met Met Met Lys His Gly Glu Asp Ile Ala Lys Gln 
    370                 375                 380                 

Tyr Asp Leu Ser Ser Leu Glu Leu Leu Val Ser Val Gly Glu Pro Phe 
385                 390                 395                 400 

Asn Pro Glu Ala Trp His Trp Val Arg Arg Val Val Gly Gly Asp Val 
                405                 410                 415     

Ala Val Ile Asn Asn Thr Trp Gly Gln Thr Glu Thr Gly Gly Thr Pro 
            420                 425                 430         

Leu Ala Leu Leu Pro Gly Ala Val Pro Met Lys Pro Gly Ser Cys Gly 
        435                 440                 445             

Val Pro Phe Phe Gly His Asp Leu Ala Val Val Asp Glu Gln Gly Arg 
    450                 455                 460                 

Glu Val Pro Asp Gly Val Pro Gly Tyr Leu Val Ile Arg Arg Pro Phe 
465                 470                 475                 480 

Pro Ser Leu Ala Arg Asp Val Tyr Gly Asp Arg Asn Leu Tyr Leu Asn 
                485                 490                 495     

Ala Tyr Phe Ser Arg Met Pro Gly Leu Tyr Phe Thr Gly Asp Ser Ala 
            500                 505                 510         

Val Arg Asp Ala Asp Gly His Phe Trp Val Leu Gly Arg Val Asp Asp 
        515                 520                 525             

Val Ile Asn Val Ser Gly His Arg Ile Ser Thr Met Glu Met Glu Ser 
    530                 535                 540                 

Ser Leu Ile Gln His Pro Ala Val Val Glu Ala Ala Val Val Gly Glu 
545                 550                 555                 560 

Pro Asp Asp Val Lys Gly Gln Val Pro Val Ala Phe Val Thr Leu Glu 
                565                 570                 575     

Arg Gly Trp Glu Pro Ser Thr Asp Leu Glu Glu Glu Leu Lys Ala Arg 
            580                 585                 590         

Val Val Ala Asp Ile Gly Ser Phe Ala Arg Pro Ala Arg Val Tyr Phe 
        595                 600                 605             

Val Glu Ala Met Pro Lys Thr Arg Ser Gly Lys Ile Leu Arg Arg Met 
    610                 615                 620                 

Leu Arg Glu Ile Leu Gln Thr Gly Glu Val Lys Gly Asp Val Thr Gly 
625                 630                 635                 640 

Leu Glu Asp Trp Glu Val Val Glu Arg Leu Leu His Asp Leu Arg Glu 
                645                 650                 655     

Arg Ala Pro Gly Gly Glu 
            660         

<210>   417
<211>   662
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   417
Met Arg Arg Asp Pro Arg Gly Arg Arg Ser Val Glu His Asp Arg Glu 
                5                   10                  15      

Arg Pro Ala His Pro Ala Thr Gly Gly Leu Arg Gly Pro Val Leu Ser 
            20                  25                  30          

Leu Glu Leu Arg Arg Val Pro Arg Glu Ile Ser Ser Val His Arg Arg 
        35                  40                  45              

Ser Gly Gly Ile Leu Gly Arg Asp Arg Arg Arg Val Gly Met Ala Ala 
    50                  55                  60                  

Ala Arg Lys Asp Gly His Arg Gly Arg Ala Ser Arg Phe Ser Val Leu 
65                  70                  75                  80  

Ser Arg Lys Leu His Gln Arg Val Arg Lys Leu Arg Gly Ser Thr Ser 
                85                  90                  95      

Gln Ala Pro Asp Val Arg Asn Lys Val Ala Leu Phe Phe Glu Gly Glu 
            100                 105                 110         

Asp Gly Glu Arg Arg Ser Val Thr Tyr Leu Gln Leu Gln Asp Ala Val 
        115                 120                 125             

Ser Arg Phe Ala Asn Ala Leu Lys Asp Leu Gly Leu Arg Gln Gly Asp 
    130                 135                 140                 

Val Val Cys Val Tyr Met Gln Asn Leu Ile Glu Thr Tyr Val Ala Leu 
145                 150                 155                 160 

Leu Ala Cys Leu Arg Ile Gly Val Leu Tyr Asn Thr Val Phe Ala Gly 
                165                 170                 175     

Phe Ser Ala Glu Ala Leu Arg Glu Arg Ile Val Lys Cys Gly Ala Lys 
            180                 185                 190         

Ala Val Ile Cys Ala Asn Gly Ser Leu Arg Arg Gly Arg Val Leu Arg 
        195                 200                 205             

Leu Lys Glu Thr Val Asp Arg Ala Leu Glu Gly Val Glu Thr Val Glu 
    210                 215                 220                 

His Val Ile Val Tyr Arg Arg Leu Pro Asp Leu Asp Thr Pro Met Thr 
225                 230                 235                 240 

Pro Gly Arg Asp Leu Asp Phe Glu Ser Leu Val Glu Arg Ala Ser Arg 
                245                 250                 255     

Asp Cys Pro Pro Ala Val Leu Glu Ala Asn Glu Pro Ala Phe Leu Ile 
            260                 265                 270         

Phe Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ile Val His Ala Gly 
        275                 280                 285             

Gly Gly Phe Leu Leu Gly Thr Tyr Ala Tyr Thr Lys Tyr Gln Leu Asp 
    290                 295                 300                 

Leu Arg Pro Glu Asp Val Tyr Trp Asn Thr Ala Asp Ile Gly Trp Leu 
305                 310                 315                 320 

Thr Ser His Ile Phe Val Leu Val Gly Gly Leu Ala Leu Gly Thr Thr 
                325                 330                 335     

Thr Ile Leu Tyr Glu Gly Ala Leu Asp Trp Pro Lys Ser Gly Arg Leu 
            340                 345                 350         

Tyr Glu Met Ile Glu Arg Tyr Arg Val Asn Lys Leu Phe Ser Ala Pro 
        355                 360                 365             

Thr Ala Tyr Arg Met Met Met Lys His Gly Glu Asp Ile Ala Arg Gln 
    370                 375                 380                 

Tyr Asp Leu Ser Ser Leu Glu Leu Leu Val Ser Val Gly Glu Pro Phe 
385                 390                 395                 400 

Asn Pro Glu Ala Trp His Trp Val Arg Arg Val Val Gly Gly Asp Val 
                405                 410                 415     

Ala Val Ile Asn Asn Thr Trp Gly Gln Thr Glu Thr Gly Gly Thr Pro 
            420                 425                 430         

Leu Ala Leu Leu Pro Gly Ala Val Pro Met Lys Pro Gly Ser Cys Gly 
        435                 440                 445             

Val Pro Phe Phe Gly His Asp Leu Ala Val Val Asp Glu Gln Gly Arg 
    450                 455                 460                 

Glu Val Pro Asp Gly Val Pro Gly Tyr Leu Val Ile Arg Arg Pro Phe 
465                 470                 475                 480 

Pro Ser Leu Ala Arg Asp Val Tyr Gly Asp Arg Asn Leu Tyr Leu Asn 
                485                 490                 495     

Ala Tyr Phe Ser Arg Met Pro Gly Leu Tyr Phe Thr Gly Asp Ser Ala 
            500                 505                 510         

Val Arg Asp Ala Asp Gly His Phe Trp Val Leu Gly Arg Val Asp Asp 
        515                 520                 525             

Val Ile Asn Val Ser Gly His Arg Ile Ser Thr Met Glu Met Glu Ser 
    530                 535                 540                 

Ser Leu Ile Gln His Pro Ala Val Val Glu Ala Ala Val Val Gly Glu 
545                 550                 555                 560 

Pro Asp Asp Val Lys Gly Gln Val Pro Val Ala Phe Val Thr Leu Glu 
                565                 570                 575     

Arg Gly Trp Glu Pro Ser Thr Asp Leu Glu Glu Glu Leu Lys Ala Arg 
            580                 585                 590         

Val Val Ala Asp Ile Gly Ser Phe Ala Arg Pro Ala Arg Val Tyr Phe 
        595                 600                 605             

Val Glu Ala Met Pro Lys Thr Arg Ser Gly Lys Ile Leu Arg Arg Met 
    610                 615                 620                 

Leu Arg Glu Ile Leu Gln Thr Gly Glu Val Lys Gly Asp Val Thr Gly 
625                 630                 635                 640 

Leu Glu Asp Trp Glu Val Val Glu Arg Leu Leu His Asp Leu Arg Glu 
                645                 650                 655     

Arg Ala Pro Gly Gly Glu 
            660         

<210>   418
<211>   662
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   418
Met Arg Arg Asp Pro Arg Gly Arg Arg Ser Val Glu His Asp Arg Glu 
                5                   10                  15      

Arg Pro Ala His Pro Ala Thr Gly Gly Leu Arg Gly Pro Val Leu Ser 
            20                  25                  30          

Leu Glu Leu Arg Arg Val Pro Arg Glu Leu Ser Ser Val His Arg Arg 
        35                  40                  45              

Ser Gly Gly Ile Leu Gly Arg Asp Arg Arg Arg Val Gly Met Ala Ala 
    50                  55                  60                  

Ala Arg Lys Asp Gly His Arg Gly Arg Ala Ser Arg Phe Ser Val Leu 
65                  70                  75                  80  

Ser Arg Lys Leu His Gln Arg Val Arg Lys Leu Arg Gly Ser Thr Ser 
                85                  90                  95      

Gln Ala Pro Asp Val Arg Asn Lys Val Ala Leu Phe Phe Glu Gly Glu 
            100                 105                 110         

Asp Gly Glu Arg Arg Ser Val Thr Tyr Leu Gln Leu Gln Asp Ala Val 
        115                 120                 125             

Ser Arg Phe Ala Asn Ala Leu Lys Asp Leu Gly Leu Arg Gln Gly Asp 
    130                 135                 140                 

Val Val Cys Val Tyr Met Gln Asn Leu Ile Glu Thr Tyr Val Ala Leu 
145                 150                 155                 160 

Leu Ala Cys Leu Arg Ile Gly Val Leu Tyr Asn Thr Val Phe Ala Gly 
                165                 170                 175     

Phe Ser Ala Glu Ala Leu Arg Glu Arg Ile Val Arg Cys Gly Ala Lys 
            180                 185                 190         

Ala Val Ile Cys Ala Asn Gly Ser Leu Arg Arg Gly Arg Val Leu Arg 
        195                 200                 205             

Leu Lys Glu Thr Val Asp Arg Ala Leu Glu Gly Val Glu Thr Val Glu 
    210                 215                 220                 

His Val Ile Val Tyr Arg Arg Leu Pro Asp Leu Asp Thr Pro Met Thr 
225                 230                 235                 240 

Pro Gly Arg Asp Leu Asp Phe Glu Ser Leu Val Glu Arg Ala Ser Arg 
                245                 250                 255     

Asp Cys Pro Pro Ala Val Leu Glu Ala Asn Glu Pro Ala Phe Leu Ile 
            260                 265                 270         

Phe Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ile Val His Ala Gly 
        275                 280                 285             

Gly Gly Phe Leu Leu Gly Thr Tyr Ala Tyr Thr Lys Tyr Gln Leu Asp 
    290                 295                 300                 

Leu Arg Pro Glu Asp Val Tyr Trp Asn Thr Ala Asp Ile Gly Trp Leu 
305                 310                 315                 320 

Thr Ser His Ile Phe Val Leu Val Gly Gly Leu Ala Leu Gly Thr Thr 
                325                 330                 335     

Thr Ile Leu Tyr Glu Gly Ala Leu Asp Trp Pro Lys Ser Gly Arg Leu 
            340                 345                 350         

Tyr Glu Met Ile Glu Arg Tyr Arg Val Asn Lys Leu Phe Ser Ala Pro 
        355                 360                 365             

Thr Ala Tyr Arg Met Met Met Lys His Gly Glu Asp Ile Ala Arg Gln 
    370                 375                 380                 

Tyr Asp Leu Ser Ser Leu Glu Leu Leu Val Ser Val Gly Glu Pro Phe 
385                 390                 395                 400 

Asn Pro Glu Ala Trp His Trp Val Arg Arg Val Val Gly Gly Asp Val 
                405                 410                 415     

Ala Val Ile Asn Asn Thr Trp Gly Gln Thr Glu Thr Gly Gly Thr Pro 
            420                 425                 430         

Leu Ala Leu Leu Pro Gly Ala Val Pro Met Lys Pro Gly Ser Cys Gly 
        435                 440                 445             

Val Pro Phe Phe Gly His Asp Leu Ala Val Val Asp Glu Gln Gly Arg 
    450                 455                 460                 

Glu Val Pro Asp Gly Val Pro Gly Tyr Leu Val Ile Arg Arg Pro Phe 
465                 470                 475                 480 

Pro Ser Leu Ala Arg Asp Val Tyr Gly Asp Arg Asn Leu Tyr Leu Asn 
                485                 490                 495     

Ala Tyr Phe Ser Arg Met Pro Gly Leu Tyr Phe Thr Gly Asp Ser Ala 
            500                 505                 510         

Val Arg Asp Ala Asp Gly His Phe Trp Val Leu Gly Arg Val Asp Asp 
        515                 520                 525             

Val Ile Asn Val Ser Gly His Arg Ile Ser Thr Met Glu Met Glu Ser 
    530                 535                 540                 

Ser Leu Ile Gln His Pro Ala Val Val Glu Ala Ala Val Val Gly Glu 
545                 550                 555                 560 

Pro Asp Asp Val Lys Gly Gln Val Pro Val Ala Phe Val Thr Leu Glu 
                565                 570                 575     

Arg Gly Trp Glu Pro Ser Thr Asp Leu Glu Glu Glu Leu Lys Ala Arg 
            580                 585                 590         

Val Val Ala Asp Ile Gly Ser Phe Ala Arg Pro Ala Arg Val Tyr Phe 
        595                 600                 605             

Val Glu Ala Met Pro Lys Thr Arg Ser Gly Lys Ile Leu Arg Arg Met 
    610                 615                 620                 

Leu Arg Glu Ile Leu Gln Thr Gly Glu Val Lys Gly Asp Val Thr Gly 
625                 630                 635                 640 

Leu Glu Asp Trp Glu Val Val Glu Arg Leu Leu His Asp Leu Arg Glu 
                645                 650                 655     

Arg Ala Pro Gly Gly Glu 
            660         

<210>   419
<211>   662
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   419
Met Arg Arg Asp Pro Arg Gly Arg Arg Ser Val Glu His Asp Arg Glu 
                5                   10                  15      

Arg Pro Ala His Pro Ala Thr Gly Gly Leu Arg Gly Pro Val Leu Ser 
            20                  25                  30          

Leu Glu Leu Arg Arg Val Pro Arg Glu Ile Ser Ser Val His Arg Arg 
        35                  40                  45              

Ser Gly Gly Ile Leu Gly Arg Asp Arg Arg Arg Val Gly Met Ala Ala 
    50                  55                  60                  

Ala Arg Lys Asp Gly His Arg Gly Arg Ala Ser Arg Phe Ser Val Leu 
65                  70                  75                  80  

Ser Arg Lys Leu His Gln Arg Val Arg Lys Leu Arg Gly Ser Thr Ser 
                85                  90                  95      

Gln Ala Pro Asp Val Arg Asn Lys Val Ala Leu Phe Phe Glu Gly Glu 
            100                 105                 110         

Asp Gly Glu Arg Arg Ser Val Thr Tyr Leu Gln Leu Asn Asp Ala Val 
        115                 120                 125             

Ser Arg Phe Ala Asn Ala Leu Lys Asp Leu Gly Leu Arg Gln Gly Asp 
    130                 135                 140                 

Val Val Cys Val Tyr Met Gln Asn Leu Ile Glu Thr Tyr Val Ala Leu 
145                 150                 155                 160 

Leu Ala Cys Leu Arg Ile Gly Val Leu Tyr Asn Thr Val Phe Ala Gly 
                165                 170                 175     

Phe Ser Ala Glu Ala Leu Arg Glu Arg Ile Val Arg Cys Gly Ala Lys 
            180                 185                 190         

Ala Val Ile Cys Ala Asn Gly Ser Leu Arg Arg Gly Arg Val Leu Arg 
        195                 200                 205             

Leu Lys Glu Thr Val Asp Arg Ala Leu Glu Gly Val Glu Thr Val Glu 
    210                 215                 220                 

His Val Ile Val Tyr Arg Arg Leu Pro Asp Leu Asp Thr Pro Met Thr 
225                 230                 235                 240 

Pro Gly Arg Asp Leu Asp Phe Glu Ser Leu Val Glu Arg Ala Ser Arg 
                245                 250                 255     

Asp Cys Pro Pro Ala Val Leu Glu Ala Asn Glu Pro Ala Phe Leu Ile 
            260                 265                 270         

Phe Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ile Val His Ala Gly 
        275                 280                 285             

Gly Gly Phe Leu Leu Gly Thr Tyr Ala Tyr Thr Lys Tyr Gln Leu Asp 
    290                 295                 300                 

Leu Arg Pro Glu Asp Val Tyr Trp Asn Thr Ala Asp Ile Gly Trp Leu 
305                 310                 315                 320 

Thr Ser His Ile Phe Val Leu Val Gly Gly Leu Ala Leu Gly Thr Thr 
                325                 330                 335     

Thr Ile Leu Tyr Glu Gly Ala Leu Asp Trp Pro Lys Ser Gly Arg Leu 
            340                 345                 350         

Tyr Glu Met Ile Glu Arg Tyr Arg Val Asn Lys Leu Phe Ser Ala Pro 
        355                 360                 365             

Thr Ala Tyr Arg Met Met Met Lys His Gly Glu Asp Ile Ala Arg Gln 
    370                 375                 380                 

Tyr Asp Leu Ser Ser Leu Glu Leu Leu Val Ser Val Gly Glu Pro Phe 
385                 390                 395                 400 

Asn Pro Glu Ala Trp His Trp Val Arg Arg Val Val Gly Gly Asp Val 
                405                 410                 415     

Ala Val Ile Asn Asn Thr Trp Gly Gln Thr Glu Thr Gly Gly Thr Pro 
            420                 425                 430         

Leu Ala Leu Leu Pro Gly Ala Val Pro Met Lys Pro Gly Ser Cys Gly 
        435                 440                 445             

Val Pro Phe Phe Gly His Asp Leu Ala Val Val Asp Glu Gln Gly Arg 
    450                 455                 460                 

Glu Val Pro Asp Gly Val Pro Gly Tyr Leu Val Ile Arg Arg Pro Phe 
465                 470                 475                 480 

Pro Ser Leu Ala Arg Asp Val Tyr Gly Asp Arg Asn Leu Tyr Leu Asn 
                485                 490                 495     

Ala Tyr Phe Ser Arg Met Pro Gly Leu Tyr Phe Thr Gly Asp Ser Ala 
            500                 505                 510         

Val Arg Asp Ala Asp Gly His Phe Trp Val Leu Gly Arg Val Asp Asp 
        515                 520                 525             

Val Ile Asn Val Ser Gly His Arg Ile Ser Thr Met Glu Met Glu Ser 
    530                 535                 540                 

Ser Leu Ile Gln His Pro Ala Val Val Glu Ala Ala Val Val Gly Glu 
545                 550                 555                 560 

Pro Asp Asp Val Lys Gly Gln Val Pro Val Ala Phe Val Thr Leu Glu 
                565                 570                 575     

Arg Gly Trp Glu Pro Ser Thr Asp Leu Glu Glu Glu Leu Lys Ala Arg 
            580                 585                 590         

Val Val Ala Asp Ile Gly Ser Phe Ala Arg Pro Ala Arg Val Tyr Phe 
        595                 600                 605             

Val Glu Ala Met Pro Lys Thr Arg Ser Gly Lys Ile Leu Arg Arg Met 
    610                 615                 620                 

Leu Arg Glu Ile Leu Gln Thr Gly Glu Val Lys Gly Asp Val Thr Gly 
625                 630                 635                 640 

Leu Glu Asp Trp Glu Val Val Glu Arg Leu Leu His Asp Leu Arg Glu 
                645                 650                 655     

Arg Ala Pro Gly Gly Glu 
            660         

<210>   420
<211>   662
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   420
Met Arg Arg Asp Pro Arg Gly Arg Arg Ser Val Glu His Asp Arg Glu 
                5                   10                  15      

Arg Pro Ala His Pro Ala Thr Gly Gly Leu Arg Gly Pro Val Leu Ser 
            20                  25                  30          

Leu Glu Leu Arg Arg Val Pro Arg Glu Ile Ser Ser Val His Arg Arg 
        35                  40                  45              

Ser Gly Gly Ile Leu Gly Arg Asp Arg Arg Arg Val Gly Met Ala Ala 
    50                  55                  60                  

Ala Arg Lys Asp Gly His Arg Gly Arg Ala Ser Arg Phe Ser Val Leu 
65                  70                  75                  80  

Ser Arg Lys Leu His Gln Arg Val Arg Lys Leu Arg Gly Ser Thr Ser 
                85                  90                  95      

Gln Ala Pro Asp Val Arg Asn Lys Val Ala Leu Phe Phe Glu Gly Glu 
            100                 105                 110         

Asp Gly Glu Arg Arg Ser Val Thr Tyr Leu Gln Leu Gln Asp Ala Val 
        115                 120                 125             

Ser Arg Phe Ala Asn Ala Leu Lys Asp Leu Gly Leu Arg Gln Gly Asp 
    130                 135                 140                 

Val Val Cys Val Tyr Met Gln Asn Leu Ile Glu Thr Tyr Val Ala Leu 
145                 150                 155                 160 

Leu Ala Cys Leu Arg Ile Gly Val Leu Tyr Asn Thr Val Phe Ala Gly 
                165                 170                 175     

Phe Ser Ala Glu Ala Leu Arg Glu Arg Ile Val Arg Cys Gly Ala Lys 
            180                 185                 190         

Ala Val Ile Cys Ala Asn Gly Ser Leu Arg Arg Gly Arg Val Leu Arg 
        195                 200                 205             

Leu Lys Glu Thr Val Asp Arg Ala Leu Glu Gly Val Glu Thr Val Glu 
    210                 215                 220                 

His Val Ile Val Tyr Arg Arg Leu Pro Asp Leu Asp Thr Pro Met Thr 
225                 230                 235                 240 

Pro Gly Arg Asp Leu Asp Phe Glu Ser Leu Val Glu Arg Ala Ser Arg 
                245                 250                 255     

Asp Cys Pro Pro Ala Val Leu Glu Ala Asn Glu Pro Ala Phe Leu Ile 
            260                 265                 270         

Phe Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ile Val His Ala Gly 
        275                 280                 285             

Gly Gly Phe Leu Leu Gly Thr Tyr Ala Tyr Thr Lys Tyr Gln Leu Asp 
    290                 295                 300                 

Leu Arg Pro Glu Asp Val Tyr Trp Asn Thr Ala Asp Ile Gly Trp Leu 
305                 310                 315                 320 

Thr Ser His Ile Phe Val Leu Val Gly Gly Leu Ala Leu Gly Thr Thr 
                325                 330                 335     

Thr Ile Leu Tyr Glu Gly Ala Leu Asp Trp Pro Lys Ser Gly Arg Leu 
            340                 345                 350         

Tyr Glu Met Ile Glu Arg Tyr Arg Val Asn Lys Leu Phe Ser Ala Pro 
        355                 360                 365             

Thr Ala Tyr Arg Met Met Met Lys His Gly Glu Asp Ile Ala Arg Gln 
    370                 375                 380                 

Tyr Asp Leu Ser Ser Leu Glu Leu Leu Val Ser Val Gly Glu Pro Phe 
385                 390                 395                 400 

Asn Pro Glu Ala Trp His Trp Val Arg Arg Val Val Gly Gly Asp Val 
                405                 410                 415     

Ala Val Ile Gln Asn Thr Trp Gly Gln Thr Glu Thr Gly Gly Thr Pro 
            420                 425                 430         

Leu Ala Leu Leu Pro Gly Ala Val Pro Met Lys Pro Gly Ser Cys Gly 
        435                 440                 445             

Val Pro Phe Phe Gly His Asp Leu Ala Val Val Asp Glu Gln Gly Arg 
    450                 455                 460                 

Glu Val Pro Asp Gly Val Pro Gly Tyr Leu Val Ile Arg Arg Pro Phe 
465                 470                 475                 480 

Pro Ser Leu Ala Arg Asp Val Tyr Gly Asp Arg Asn Leu Tyr Leu Asn 
                485                 490                 495     

Ala Tyr Phe Ser Arg Met Pro Gly Leu Tyr Phe Thr Gly Asp Ser Ala 
            500                 505                 510         

Val Arg Asp Ala Asp Gly His Phe Trp Val Leu Gly Arg Val Asp Asp 
        515                 520                 525             

Val Ile Asn Val Ser Gly His Arg Ile Ser Thr Met Glu Met Glu Ser 
    530                 535                 540                 

Ser Leu Ile Gln His Pro Ala Val Val Glu Ala Ala Val Val Gly Glu 
545                 550                 555                 560 

Pro Asp Asp Val Lys Gly Gln Val Pro Val Ala Phe Val Thr Leu Glu 
                565                 570                 575     

Arg Gly Trp Glu Pro Ser Thr Asp Leu Glu Glu Glu Leu Lys Ala Arg 
            580                 585                 590         

Val Val Ala Asp Ile Gly Ser Phe Ala Arg Pro Ala Arg Val Tyr Phe 
        595                 600                 605             

Val Glu Ala Met Pro Lys Thr Arg Ser Gly Lys Ile Leu Arg Arg Met 
    610                 615                 620                 

Leu Arg Glu Ile Leu Gln Thr Gly Glu Val Lys Gly Asp Val Thr Gly 
625                 630                 635                 640 

Leu Glu Asp Trp Glu Val Val Glu Arg Leu Leu His Asp Leu Arg Glu 
                645                 650                 655     

Arg Ala Pro Gly Gly Glu 
            660         

<210>   421
<211>   1989
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   421
ttgaggaggg atcctcgtgg cagacgaagt gttgagcatg atcgcgagcg cccggctcat       60

cccgccaccg gaggcctacg cggcccggtc ttatctctcg agctacgacg agtaccgcgc      120

gagatatcaa gcgtccatcg acgatccggc ggcattctgg gacgagatcg ccgacgagtt      180

ggtatggcag cagcgcggaa agacggtcat cgcgggcgag cttcccgatt ttcagttctt      240

tcccggaagt tacatcaacg tgtgcgaaaa ctgcgtggat cgacaagcca agcacccgat      300

gtacgcaaca aggtggcgct cttcttcgag ggggaggacg gcgaacgccg cagcgtgacg      360

tacctccagc tccaggatgc cgtgtcccgg tttgcgaacg cgctcaaaga tctcgggctg      420

cgacagggcg atgtggtctg cgtgtacatg caaaatctca tcgagaccta cgtcgcgctc      480

ttggcgtgcc tgcgcatcgg cgtgctctac aacacggtgt ttgcgggatt ttccgccgag      540

gcgctgcgcg agcggattgt gcggtgcggg gccaaggcgg tgatctgcgc caacggaagt      600

ctcaggcgcg gccgggtgct tcggctgaag gaaaccgtcg accgggcgct tgaaggtgtg      660

gagaccgtgg agcacgtcat cgtctaccgg cgcctgcccg atctcgacac gccgatgacg      720

ccggggcgcg atctcgactt tgagtcgctc gtcgagcgcg cctcccggga ctgccctcct      780

gctgtactgg aggcgaacga gcccgccttc ctcatcttca cgagcggaac gacgggccgg      840

ccgaaaggca tcgtccacgc cggcggcgga tttctgcttg gaacctacgc gtacacgaag      900

taccagctcg acctccggcc cgaggacgtg tactggaaca cagcggacat cggctggctc      960

acatctcaca tcttcgtgct ggtcggcggt ctcgccttag gcaccacgac catcctgtac     1020

gagggcgcgc tggattggcc caaatcgggc aggctatacg agatgatcga gcgataccgc     1080

gtcaacaaac tgttctcggc acccaccgcc tatcggatga tgatgaaaca cggcgaggac     1140

atcgcgaaac aatacgactt gtcgtcgctt gaactcttgg tgtcggtcgg agagccgttc     1200

aatcccgagg cgtggcattg ggtccgccgc gttgtcggcg gtgacgtcgc tgtcatcaac     1260

aacacctggg gccagaccga gaccggtgga acgccgctcg cgctgttgcc aggggcggtg     1320

cccatgaaac ccggctcgtg tggcgtgccg ttcttcggac acgatctcgc cgtcgtggat     1380

gaacagggcc gggaggtgcc ggacggggtg cccggatatc tcgtgatccg ccgtccgttc     1440

ccgtcgctcg cgcgcgacgt gtacggcgat cggaacctgt acctgaacgc gtacttctcg     1500

cgtatgcccg ggctctactt cacgggcgac agcgcggtcc gggatgcgga tggccacttc     1560

tgggtgctcg gccgggtcga cgacgtgatc aacgtgtcgg gccaccgaat cagcacgatg     1620

gagatggaga gctcgctcat ccagcatccg gccgtggtgg aggcggcggt cgtgggcgag     1680

cctgacgacg tgaagggcca ggtccccgtt gcgttcgtga cgctcgagcg cgggtgggaa     1740

ccgagcacgg acctggagga ggaactgaag gcgcgcgtcg tggcggacat cggttcgttt     1800

gcgcggccgg cgcgcgtgta cttcgtggag gcgatgccga agacgcgatc gggcaagatc     1860

ctgcggcgga tgctgcgcga gatcctgcag acgggcgaag tgaaagggga cgtcaccggc     1920

ctggaggact gggaggtcgt ggaacggctt ctgcacgatt tgcgcgagcg ggcgccgggc     1980

ggtgaatga                                                             1989


<210>   422
<211>   1989
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   422
ttgaggaggg atcctcgtgg cagacgaagt gttgagcatg atcgcgagcg cccggctcat       60

cccgccaccg gaggcctacg cggcccggtc ttatctctcg agctacgacg agtaccgcgc      120

gagatatcaa gcgtccatcg acgatccggc ggcattctgg gacgagatcg ccgacgagtt      180

ggtatggcag cagcgcggaa agacggtcat cgcgggcgag cttcccgatt ttcagttctt      240

tcccggaagt tacatcaacg tgtgcgaaaa ctgcgtggat cgacaagcca agcacccgat      300

gtacgcaaca aggtggcgct cttcttcgag ggggaggacg gcgaacgccg cagcgtgacg      360

tacctccagc tccaggatgc cgtgtcccgg tttgcgaacg cgctcaaaga tctcgggctg      420

cgacagggcg atgtggtctg cgtgtacatg caaaatctca tcgagaccta cgtcgcgctc      480

ttggcgtgcc tgcgcatcgg cgtgctctac aacacggtgt ttgcgggatt ttccgccgag      540

gcgctgcgcg agcggattgt gaaatgcggg gccaaggcgg tgatctgcgc caacggaagt      600

ctcaggcgcg gccgggtgct tcggctgaag gaaaccgtcg accgggcgct tgaaggtgtg      660

gagaccgtgg agcacgtcat cgtctaccgg cgcctgcccg atctcgacac gccgatgacg      720

ccggggcgcg atctcgactt tgagtcgctc gtcgagcgcg cctcccggga ctgccctcct      780

gctgtactgg aggcgaacga gcccgccttc ctcatcttca cgagcggaac gacgggccgg      840

ccgaaaggca tcgtccacgc cggcggcgga tttctgcttg gaacctacgc gtacacgaag      900

taccagctcg acctccggcc cgaggacgtg tactggaaca cagcggacat cggctggctc      960

acatctcaca tcttcgtgct ggtcggcggt ctcgccttag gcaccacgac catcctgtac     1020

gagggcgcgc tggattggcc caaatcgggc aggctatacg agatgatcga gcgataccgc     1080

gtcaacaaac tgttctcggc acccaccgcc tatcggatga tgatgaaaca cggcgaggac     1140

atcgcgcggc aatacgactt gtcgtcgctt gaactcttgg tgtcggtcgg agagccgttc     1200

aatcccgagg cgtggcattg ggtccgccgc gttgtcggcg gtgacgtcgc tgtcatcaac     1260

aacacctggg gccagaccga gaccggtgga acgccgctcg cgctgttgcc aggggcggtg     1320

cccatgaaac ccggctcgtg tggcgtgccg ttcttcggac acgatctcgc cgtcgtggat     1380

gaacagggcc gggaggtgcc ggacggggtg cccggatatc tcgtgatccg ccgtccgttc     1440

ccgtcgctcg cgcgcgacgt gtacggcgat cggaacctgt acctgaacgc gtacttctcg     1500

cgtatgcccg ggctctactt cacgggcgac agcgcggtcc gggatgcgga tggccacttc     1560

tgggtgctcg gccgggtcga cgacgtgatc aacgtgtcgg gccaccgaat cagcacgatg     1620

gagatggaga gctcgctcat ccagcatccg gccgtggtgg aggcggcggt cgtgggcgag     1680

cctgacgacg tgaagggcca ggtccccgtt gcgttcgtga cgctcgagcg cgggtgggaa     1740

ccgagcacgg acctggagga ggaactgaag gcgcgcgtcg tggcggacat cggttcgttt     1800

gcgcggccgg cgcgcgtgta cttcgtggag gcgatgccga agacgcgatc gggcaagatc     1860

ctgcggcgga tgctgcgcga gatcctgcag acgggcgaag tgaaagggga cgtcaccggc     1920

ctggaggact gggaggtcgt ggaacggctt ctgcacgatt tgcgcgagcg ggcgccgggc     1980

ggtgaatga                                                             1989


<210>   423
<211>   1989
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   423
ttgaggaggg atcctcgtgg cagacgaagt gttgagcatg atcgcgagcg cccggctcat       60

cccgccaccg gaggcctacg cggcccggtc ttatctctcg agctacgacg agtaccgcgc      120

gagttatcaa gcgtccatcg acgatccggc ggcattctgg gacgagatcg ccgacgagtt      180

ggtatggcag cagcgcggaa agacggtcat cgcgggcgag cttcccgatt ttcagttctt      240

tcccggaagt tacatcaacg tgtgcgaaaa ctgcgtggat cgacaagcca agcacccgat      300

gtacgcaaca aggtggcgct cttcttcgag ggggaggacg gcgaacgccg cagcgtgacg      360

tacctccagc tccaggatgc cgtgtcccgg tttgcgaacg cgctcaaaga tctcgggctg      420

cgacagggcg atgtggtctg cgtgtacatg caaaatctca tcgagaccta cgtcgcgctc      480

ttggcgtgcc tgcgcatcgg cgtgctctac aacacggtgt ttgcgggatt ttccgccgag      540

gcgctgcgcg agcggattgt gcggtgcggg gccaaggcgg tgatctgcgc caacggaagt      600

ctcaggcgcg gccgggtgct tcggctgaag gaaaccgtcg accgggcgct tgaaggtgtg      660

gagaccgtgg agcacgtcat cgtctaccgg cgcctgcccg atctcgacac gccgatgacg      720

ccggggcgcg atctcgactt tgagtcgctc gtcgagcgcg cctcccggga ctgccctcct      780

gctgtactgg aggcgaacga gcccgccttc ctcatcttca cgagcggaac gacgggccgg      840

ccgaaaggca tcgtccacgc cggcggcgga tttctgcttg gaacctacgc gtacacgaag      900

taccagctcg acctccggcc cgaggacgtg tactggaaca cagcggacat cggctggctc      960

acatctcaca tcttcgtgct ggtcggcggt ctcgccttag gcaccacgac catcctgtac     1020

gagggcgcgc tggattggcc caaatcgggc aggctatacg agatgatcga gcgataccgc     1080

gtcaacaaac tgttctcggc acccaccgcc tatcggatga tgatgaaaca cggcgaggac     1140

atcgcgcggc aatacgactt gtcgtcgctt gaactcttgg tgtcggtcgg agagccgttc     1200

aatcccgagg cgtggcattg ggtccgccgc gttgtcggcg gtgacgtcgc tgtcatcaac     1260

aacacctggg gccagaccga gaccggtgga acgccgctcg cgctgttgcc aggggcggtg     1320

cccatgaaac ccggctcgtg tggcgtgccg ttcttcggac acgatctcgc cgtcgtggat     1380

gaacagggcc gggaggtgcc ggacggggtg cccggatatc tcgtgatccg ccgtccgttc     1440

ccgtcgctcg cgcgcgacgt gtacggcgat cggaacctgt acctgaacgc gtacttctcg     1500

cgtatgcccg ggctctactt cacgggcgac agcgcggtcc gggatgcgga tggccacttc     1560

tgggtgctcg gccgggtcga cgacgtgatc aacgtgtcgg gccaccgaat cagcacgatg     1620

gagatggaga gctcgctcat ccagcatccg gccgtggtgg aggcggcggt cgtgggcgag     1680

cctgacgacg tgaagggcca ggtccccgtt gcgttcgtga cgctcgagcg cgggtgggaa     1740

ccgagcacgg acctggagga ggaactgaag gcgcgcgtcg tggcggacat cggttcgttt     1800

gcgcggccgg cgcgcgtgta cttcgtggag gcgatgccga agacgcgatc gggcaagatc     1860

ctgcggcgga tgctgcgcga gatcctgcag acgggcgaag tgaaagggga cgtcaccggc     1920

ctggaggact gggaggtcgt ggaacggctt ctgcacgatt tgcgcgagcg ggcgccgggc     1980

ggtgaatga                                                             1989


<210>   424
<211>   1989
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   424
ttgaggaggg atcctcgtgg cagacgaagt gttgagcatg atcgcgagcg cccggctcat       60

cccgccaccg gaggcctacg cggcccggtc ttatctctcg agctacgacg agtaccgcgc      120

gagatatcaa gcgtccatcg acgatccggc ggcattctgg gacgagatcg ccgacgagtt      180

ggtatggcag cagcgcggaa agacggtcat cgcgggcgag cttcccgatt ttcagttctt      240

tcccggaagt tacatcaacg tgtgcgaaaa ctgcgtggat cgacaagcca agcacccgat      300

gtacgcaaca aggtggcgct cttcttcgag ggggaggacg gcgaacgccg cagcgtgacg      360

tacctccagc tcaatgatgc cgtgtcccgg tttgcgaacg cgctcaaaga tctcgggctg      420

cgacagggcg atgtggtctg cgtgtacatg caaaatctca tcgagaccta cgtcgcgctc      480

ttggcgtgcc tgcgcatcgg cgtgctctac aacacggtgt ttgcgggatt ttccgccgag      540

gcgctgcgcg agcggattgt gcggtgcggg gccaaggcgg tgatctgcgc caacggaagt      600

ctcaggcgcg gccgggtgct tcggctgaag gaaaccgtcg accgggcgct tgaaggtgtg      660

gagaccgtgg agcacgtcat cgtctaccgg cgcctgcccg atctcgacac gccgatgacg      720

ccggggcgcg atctcgactt tgagtcgctc gtcgagcgcg cctcccggga ctgccctcct      780

gctgtactgg aggcgaacga gcccgccttc ctcatcttca cgagcggaac gacgggccgg      840

ccgaaaggca tcgtccacgc cggcggcgga tttctgcttg gaacctacgc gtacacgaag      900

taccagctcg acctccggcc cgaggacgtg tactggaaca cagcggacat cggctggctc      960

acatctcaca tcttcgtgct ggtcggcggt ctcgccttag gcaccacgac catcctgtac     1020

gagggcgcgc tggattggcc caaatcgggc aggctatacg agatgatcga gcgataccgc     1080

gtcaacaaac tgttctcggc acccaccgcc tatcggatga tgatgaaaca cggcgaggac     1140

atcgcgcggc aatacgactt gtcgtcgctt gaactcttgg tgtcggtcgg agagccgttc     1200

aatcccgagg cgtggcattg ggtccgccgc gttgtcggcg gtgacgtcgc tgtcatcaac     1260

aacacctggg gccagaccga gaccggtgga acgccgctcg cgctgttgcc aggggcggtg     1320

cccatgaaac ccggctcgtg tggcgtgccg ttcttcggac acgatctcgc cgtcgtggat     1380

gaacagggcc gggaggtgcc ggacggggtg cccggatatc tcgtgatccg ccgtccgttc     1440

ccgtcgctcg cgcgcgacgt gtacggcgat cggaacctgt acctgaacgc gtacttctcg     1500

cgtatgcccg ggctctactt cacgggcgac agcgcggtcc gggatgcgga tggccacttc     1560

tgggtgctcg gccgggtcga cgacgtgatc aacgtgtcgg gccaccgaat cagcacgatg     1620

gagatggaga gctcgctcat ccagcatccg gccgtggtgg aggcggcggt cgtgggcgag     1680

cctgacgacg tgaagggcca ggtccccgtt gcgttcgtga cgctcgagcg cgggtgggaa     1740

ccgagcacgg acctggagga ggaactgaag gcgcgcgtcg tggcggacat cggttcgttt     1800

gcgcggccgg cgcgcgtgta cttcgtggag gcgatgccga agacgcgatc gggcaagatc     1860

ctgcggcgga tgctgcgcga gatcctgcag acgggcgaag tgaaagggga cgtcaccggc     1920

ctggaggact gggaggtcgt ggaacggctt ctgcacgatt tgcgcgagcg ggcgccgggc     1980

ggtgaatga                                                             1989


<210>   425
<211>   1989
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   425
ttgaggaggg atcctcgtgg cagacgaagt gttgagcatg atcgcgagcg cccggctcat       60

cccgccaccg gaggcctacg cggcccggtc ttatctctcg agctacgacg agtaccgcgc      120

gagatatcaa gcgtccatcg acgatccggc ggcattctgg gacgagatcg ccgacgagtt      180

ggtatggcag cagcgcggaa agacggtcat cgcgggcgag cttcccgatt ttcagttctt      240

tcccggaagt tacatcaacg tgtgcgaaaa ctgcgtggat cgacaagcca agcacccgat      300

gtacgcaaca aggtggcgct cttcttcgag ggggaggacg gcgaacgccg cagcgtgacg      360

tacctccagc tccaggatgc cgtgtcccgg tttgcgaacg cgctcaaaga tctcgggctg      420

cgacagggcg atgtggtctg cgtgtacatg caaaatctca tcgagaccta cgtcgcgctc      480

ttggcgtgcc tgcgcatcgg cgtgctctac aacacggtgt ttgcgggatt ttccgccgag      540

gcgctgcgcg agcggattgt gcggtgcggg gccaaggcgg tgatctgcgc caacggaagt      600

ctcaggcgcg gccgggtgct tcggctgaag gaaaccgtcg accgggcgct tgaaggtgtg      660

gagaccgtgg agcacgtcat cgtctaccgg cgcctgcccg atctcgacac gccgatgacg      720

ccggggcgcg atctcgactt tgagtcgctc gtcgagcgcg cctcccggga ctgccctcct      780

gctgtactgg aggcgaacga gcccgccttc ctcatcttca cgagcggaac gacgggccgg      840

ccgaaaggca tcgtccacgc cggcggcgga tttctgcttg gaacctacgc gtacacgaag      900

taccagctcg acctccggcc cgaggacgtg tactggaaca cagcggacat cggctggctc      960

acatctcaca tcttcgtgct ggtcggcggt ctcgccttag gcaccacgac catcctgtac     1020

gagggcgcgc tggattggcc caaatcgggc aggctatacg agatgatcga gcgataccgc     1080

gtcaacaaac tgttctcggc acccaccgcc tatcggatga tgatgaaaca cggcgaggac     1140

atcgcgcggc aatacgactt gtcgtcgctt gaactcttgg tgtcggtcgg agagccgttc     1200

aatcccgagg cgtggcattg ggtccgccgc gttgtcggcg gtgacgtcgc tgtcatccaa     1260

aacacctggg gccagaccga gaccggtgga acgccgctcg cgctgttgcc aggggcggtg     1320

cccatgaaac ccggctcgtg tggcgtgccg ttcttcggac acgatctcgc cgtcgtggat     1380

gaacagggcc gggaggtgcc ggacggggtg cccggatatc tcgtgatccg ccgtccgttc     1440

ccgtcgctcg cgcgcgacgt gtacggcgat cggaacctgt acctgaacgc gtacttctcg     1500

cgtatgcccg ggctctactt cacgggcgac agcgcggtcc gggatgcgga tggccacttc     1560

tgggtgctcg gccgggtcga cgacgtgatc aacgtgtcgg gccaccgaat cagcacgatg     1620

gagatggaga gctcgctcat ccagcatccg gccgtggtgg aggcggcggt cgtgggcgag     1680

cctgacgacg tgaagggcca ggtccccgtt gcgttcgtga cgctcgagcg cgggtgggaa     1740

ccgagcacgg acctggagga ggaactgaag gcgcgcgtcg tggcggacat cggttcgttt     1800

gcgcggccgg cgcgcgtgta cttcgtggag gcgatgccga agacgcgatc gggcaagatc     1860

ctgcggcgga tgctgcgcga gatcctgcag acgggcgaag tgaaagggga cgtcaccggc     1920

ctggaggact gggaggtcgt ggaacggctt ctgcacgatt tgcgcgagcg ggcgccgggc     1980

ggtgaatga                                                             1989


<210>   426
<211>   377
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   426
Met Asp Phe Asp Leu Thr Ser Glu Gln Lys Met Ile Arg Asp Thr Val 
                5                   10                  15      

Arg Glu Phe Ala Glu Ala Glu Ile Ala Pro His Ala Ala Glu Trp Asp 
            20                  25                  30          

Arg Thr Glu His Phe Pro Ile Glu Val Phe Arg Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Phe Leu Gly Leu Pro Ile Pro Glu Glu Tyr Gly Gly Ala Gly Ala 
    50                  55                  60                  

Asp Met Ile Ser Tyr Cys Leu Ala Val Glu Glu Ile Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Glu Ala His Val Ser Leu Ala Cys Thr 
                85                  90                  95      

Pro Ile Leu Leu Tyr Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu Val 
            100                 105                 110         

Pro Met Ala Arg Gly Glu Ala Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Thr Ala Val Leu Glu 
    130                 135                 140                 

Gly Asp Glu Trp Val Ile Thr Gly Asn Lys Ile Phe Asn Thr Asn Gly 
145                 150                 155                 160 

Gly Tyr Ala Lys Tyr Val Val Leu Thr Ala Val Thr Asp Pro Ala Ser 
                165                 170                 175     

Arg Gly Ile Ser Ala Phe Ile Val Pro Thr Asp Ala Glu Gly Phe Ser 
            180                 185                 190         

Val Ser Lys Pro Tyr Glu Lys Leu Gly Met Arg Ala Ser Asn Thr Val 
        195                 200                 205             

Glu Leu Ile Leu Asp His Val Arg Val Pro Lys Glu Asn Leu Leu Gly 
    210                 215                 220                 

Pro Leu Asn Ala Gly Phe Lys Gln Phe Leu Ser Thr Leu Asp Gly Gly 
225                 230                 235                 240 

Arg Val Ala Ile Ala Ala Leu Ala Val Gly Ile Ala Arg Ala Ala Phe 
                245                 250                 255     

Glu Thr Ala Leu Ala Tyr Ala Lys Thr Arg Val Gln Phe Gly Gln Ala 
            260                 265                 270         

Ile Ser Lys Phe Gln Ala Ile Gln His Lys Leu Ala Asp Met Ala Met 
        275                 280                 285             

His Ile Asp Leu Ala Arg Asn Ala Val Met Lys Ala Ala Trp Leu Lys 
    290                 295                 300                 

Asp Gln Gly Arg Pro Tyr Thr Leu Glu Ala Ser Tyr Ala Lys Leu Phe 
305                 310                 315                 320 

Ala Ser Glu Met Cys Thr Arg Thr Cys Glu Gln Ala Ile Gln Ile Leu 
                325                 330                 335     

Gly Gly Tyr Gly Tyr Met Arg Glu Tyr Pro Val Glu Arg His Tyr Arg 
            340                 345                 350         

Asp Ala Lys Leu Ile Glu Ile Gly Glu Gly Thr Ser Glu Ile Gln Arg 
        355                 360                 365             

Leu Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375         

<210>   427
<211>   1134
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   427
gtggactttg atctcacctc ggaacaaaag atgattcggg atacggtgcg cgagtttgcg       60

gaggccgaga tcgcgcctca cgccgcggaa tgggatagga cggagcactt ccccatcgag      120

gtgtttcgca agatgggcga actcggcttt ctcggcctgc ccattccgga ggaatacggt      180

ggcgcgggcg ccgacatgat ctcgtactgc ctggcggtgg aggagatcgg gcgcgcgtgc      240

ggcggaacag ggctcagcta cgaggcgcac gtgtcgctcg cgtgcacgcc cattctgctc      300

tacgggacgg aggagcagaa acagaagtac ctggtgccta tggcgcgcgg cgaggcgctc      360

ggtgcgtttg gtttgacgga gcccggggct ggatcggacg ccggaggaac gcggacgacc      420

gccgtcctgg agggcgacga atgggtcatc accggcaaca agatcttcaa cacaaacggc      480

ggctatgcga agtacgtcgt gctcaccgcg gtgacggatc cggcgtcgcg cggcatcagc      540

gcgttcatcg tgccgacaga tgccgagggc ttctcggtga gcaagccgta tgagaaactg      600

ggcatgcggg cgtcgaacac ggtcgaactg attctcgatc acgtccgcgt tccgaaggag      660

aacctactcg ggccgctgaa cgctgggttc aagcagtttc tctcgacgct ggacggcgga      720

cgtgtcgcca tcgcagctct ggcggtcggg atcgcgcggg cggcgtttga gacggctctc      780

gcgtacgcca agacgcgcgt ccagttcggg caggccatca gcaagttcca ggcgattcag      840

cacaagctcg ccgacatggc catgcacatc gatctcgccc ggaatgcggt gatgaaggcc      900

gcgtggctga aggatcaggg ccggccgtac acgctggagg cgtcgtacgc caagctgttt      960

gcgtccgaga tgtgcacgcg gacgtgcgag caggcgattc agatcttggg cgggtatggc     1020

tacatgcgcg aatacccggt ggagcgccac tatcgcgacg cgaagttgat cgagatcggc     1080

gagggcacgt cggagatcca gcgcctggtg atcgcgcgcc agctgggctg ttag           1134


<210>   428
<211>   380
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   428
Met Asn Phe Ser Leu Thr Lys Glu Gln Gln Met Ile Lys Glu Met Val 
                5                   10                  15      

Arg Asp Phe Ala Glu Lys Glu Ile Ala Pro Tyr Ala Ala Lys Trp Asp 
            20                  25                  30          

Glu Glu Ala His Phe Pro Leu Asp Val Phe Arg Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Leu Leu Gly Leu Pro Phe Pro Glu Glu Tyr Gly Gly Ala Gly Gly 
    50                  55                  60                  

Asp Thr Ile Ser Tyr Ala Ile Ala Val Glu Glu Ile Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Ala Ala Ala Val Ser Leu Gly Ala Ser 
                85                  90                  95      

Pro Ile Tyr Tyr Phe Gly Thr Glu Glu Gln Lys Gln Lys Trp Leu Val 
            100                 105                 110         

Pro Met Ala Lys Gly Glu Thr Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Asn Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Thr Ala Val Leu Asp 
    130                 135                 140                 

Gly Asp Glu Tyr Val Ile Asn Gly Glu Lys Cys Trp Ile Thr Asn Ala 
145                 150                 155                 160 

Gln Tyr Ala Arg Gln Val Ile Val Thr Ala Val Thr Gly Lys Asp Ala 
                165                 170                 175     

Arg Gly Lys Asn Ile Ile Thr Ala Leu Ile Val Pro Thr Asp Ser Pro 
            180                 185                 190         

Gly Phe Thr Ile Arg Ser Asn Tyr Asp Lys Met Gly Val Arg Ala Ser 
        195                 200                 205             

Asn Thr Cys Glu Leu Val Phe Glu Asn Val Arg Val Pro Lys Glu Asn 
    210                 215                 220                 

Val Leu Gly Asp Pro Gln Lys Gly Phe Lys Gln Phe Leu Tyr Thr Leu 
225                 230                 235                 240 

Asp Gly Gly Arg Ile Ser Ile Ala Ala Leu Ala Val Gly Ile Ala Gln 
                245                 250                 255     

Ala Ala Phe Glu Lys Ala Leu Gln Tyr Ala Lys Glu Arg Val Gln Phe 
            260                 265                 270         

Gly Gln Pro Ile Ser Lys Phe Gln Ala Ile Gln Phe Lys Leu Ala Asp 
        275                 280                 285             

Met Ala Met Glu Ile Glu Leu Ala Arg Asn Met Val Tyr Lys Ala Ala 
    290                 295                 300                 

Trp Leu Lys Asp Gln Gly Lys Pro Phe Thr Lys Glu Ala Ser Phe Ala 
305                 310                 315                 320 

Lys Leu Phe Ala Ser Glu Met Gly Phe Arg Val Cys Asn Gln Ala Ile 
                325                 330                 335     

Gln Ile His Gly Gly Tyr Gly Tyr Met Lys Glu Tyr Gly Val Glu Arg 
            340                 345                 350         

His Leu Arg Asp Ile Lys Leu Met Glu Ile Gly Glu Gly Thr Ser Glu 
        355                 360                 365             

Ile Gln Arg Leu Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375                 380 

<210>   429
<211>   380
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   429
Met Asp Phe Ser Leu Thr Lys Glu Gln Gln Met Ile Lys Glu Met Val 
                5                   10                  15      

Arg Asp Phe Ala Glu Lys Glu Ile Ala Pro Tyr Ala Ala Lys Trp Asp 
            20                  25                  30          

Glu Glu Ala Tyr Phe Pro Arg Glu Val Phe Arg Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Leu Leu Gly Leu Pro Phe Pro Glu Ser Tyr Gly Gly Ala Gly Gly 
    50                  55                  60                  

Asp Thr Ile Ser Tyr Ala Ile Ala Val Glu Glu Ile Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Ala Ala Ala Val Ser Leu Gly Ala Ser 
                85                  90                  95      

Pro Ile Tyr Tyr Phe Gly Ser Glu Glu Gln Lys Gln Thr Trp Leu Val 
            100                 105                 110         

Pro Met Ala Lys Gly Glu Thr Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Asn Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Thr Ala Val Leu Asp 
    130                 135                 140                 

Gly Asp Glu Tyr Val Ile Asn Gly Glu Lys Cys Trp Ile Thr Asn Ala 
145                 150                 155                 160 

Gln Tyr Ala Arg Gln Val Ile Val Thr Ala Val Thr Gly Lys Asp Ala 
                165                 170                 175     

Arg Gly Lys Asn Ile Ile Thr Ala Leu Ile Val Pro Thr Asp Ser Pro 
            180                 185                 190         

Gly Phe Thr Ile Arg Ser Asn Tyr Asp Lys Met Gly Val Arg Ala Ser 
        195                 200                 205             

Asn Thr Cys Glu Leu Val Phe Glu Asn Val Arg Val Pro Lys Glu Asn 
    210                 215                 220                 

Val Leu Gly Asp Pro Gln Lys Gly Phe Lys Gln Phe Leu Tyr Thr Leu 
225                 230                 235                 240 

Asp Gly Gly Arg Ile Ser Ile Ala Ala Leu Ala Val Gly Ile Ala Gln 
                245                 250                 255     

Ala Ala Phe Glu Lys Ala Leu Gln Tyr Ala Lys Glu Arg Val Gln Phe 
            260                 265                 270         

Gly Gln Ser Ile Ser Lys Phe Gln Ala Ile Gln Phe Lys Leu Ala Asp 
        275                 280                 285             

Met Ala Met Glu Ile Glu Leu Ala Arg Asn Met Val Tyr Lys Ala Ala 
    290                 295                 300                 

Trp Leu Lys Asp Gln Gly Lys Pro Phe Thr Lys Glu Ala Ser Phe Ala 
305                 310                 315                 320 

Lys Leu Phe Ala Ser Glu Met Gly Phe Arg Val Cys Asn Gln Ala Ile 
                325                 330                 335     

Gln Ile His Gly Gly Tyr Gly Tyr Met Lys Glu Tyr Gly Val Glu Arg 
            340                 345                 350         

His Leu Arg Asp Ile Lys Leu Met Glu Ile Gly Glu Gly Thr Ser Glu 
        355                 360                 365             

Ile Gln Arg Leu Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375                 380 

<210>   430
<211>   380
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   430
Met Asp Phe Glu Leu Ser Lys Glu Gln Ile Met Leu Gln Glu Met Val 
                5                   10                  15      

Arg Asp Phe Ala Glu Lys Glu Ile Glu Pro Tyr Ala Arg Glu Val Asp 
            20                  25                  30          

Glu Thr Gly Lys Met Arg Met Glu Thr Phe Gln Lys Leu Gly Asn Leu 
        35                  40                  45              

Gly Leu Leu Gly Ile Pro Phe Pro Glu Lys Tyr Gly Gly Ala Gly Gly 
    50                  55                  60                  

Asp Thr Ile Ser Tyr Cys Ile Ala Val Glu Glu Ile Gly Lys Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Ala Ala Asn Thr Ser Leu Gly Ala Ser 
                85                  90                  95      

Pro Ile Tyr Tyr Phe Gly Thr Glu Glu Gln Lys Gln Lys Trp Leu Val 
            100                 105                 110         

Pro Met Ala Lys Gly Glu Ala Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Asn Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Lys Ala Val Leu Asp 
    130                 135                 140                 

Gly Asp Glu Trp Val Ile Asn Gly Glu Lys Cys Trp Ile Thr Asn Ala 
145                 150                 155                 160 

Glu Tyr Ala Arg Gln Val Ile Val Thr Ala Val Thr Gly Lys Arg Glu 
                165                 170                 175     

Asn Gly Arg Asn Ile Ile Ser Ala Ile Ile Val Pro Ala Asp Ala Pro 
            180                 185                 190         

Gly Val Ala Ile Thr Ser Pro Tyr Glu Lys Met Gly Val Arg Gly Ser 
        195                 200                 205             

Asn Thr Cys Gln Ile Val Leu Glu Asn Val Arg Val Pro Arg Glu Asn 
    210                 215                 220                 

Leu Leu Gly Asp Glu Asn Lys Gly Phe Ser Gln Phe Leu Tyr Thr Leu 
225                 230                 235                 240 

Asp Gly Gly Arg Ile Ser Ile Ala Ala Leu Ser Val Gly Ile Ala Gln 
                245                 250                 255     

Ala Ala Phe Glu Lys Ala Leu Arg Tyr Ala Lys Glu Arg Met Gln Phe 
            260                 265                 270         

Gly Gln Ala Ile Ser Lys Phe Gln Ala Ile Gln Phe Lys Leu Ala Asp 
        275                 280                 285             

Met Ala Met Glu Ile Asp Leu Ala Arg Asn Ala Val Tyr Lys Ala Ala 
    290                 295                 300                 

Trp Leu Lys Asp Gln Gly Lys Pro Phe Ser Lys Glu Ala Ala Tyr Ala 
305                 310                 315                 320 

Lys Leu Phe Ala Ser Glu Met Gly Phe Arg Val Cys Asn Gln Ala Ile 
                325                 330                 335     

Gln Ile His Gly Gly Ser Gly Tyr Met Arg Glu Tyr Gly Val Glu Arg 
            340                 345                 350         

His Leu Arg Asp Ile Lys Leu Met Glu Ile Gly Glu Gly Thr Ser Glu 
        355                 360                 365             

Ile Gln Arg Leu Val Ile Ala Arg Lys Leu Gly Cys 
    370                 375                 380 

<210>   431
<211>   380
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   431
Met Asn Phe Glu Leu Thr Lys Glu Gln Gln Met Val Arg Asp Met Val 
                5                   10                  15      

Arg Asp Phe Ala Glu Asn Glu Ile Ala Pro Asn Ala Ile His Tyr Asp 
            20                  25                  30          

Lys Thr Ala Gln Phe Pro Glu Asp Val Phe Lys Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Leu Leu Gly Ile Pro Phe Pro Glu Glu Tyr Gly Gly Ser Gly Gly 
    50                  55                  60                  

Asp Thr Ile Ser Tyr Ala Leu Ala Val Glu Glu Val Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Ala Ala Ala Val Ser Leu Gly Ala Ser 
                85                  90                  95      

Pro Ile Tyr Tyr Phe Gly Thr Glu Arg Gln Lys Gln Glu His Leu Val 
            100                 105                 110         

Pro Leu Ala Thr Gly Glu Ser Leu Gly Ser Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Asn Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Lys Ala Val Leu Glu 
    130                 135                 140                 

Gly Asp Glu Tyr Val Ile Asn Gly Glu Lys Cys Trp Ile Thr Asn Ala 
145                 150                 155                 160 

Gly Tyr Ala Arg Thr Val Ile Val Thr Ala Val Thr Gly Lys Asp Glu 
                165                 170                 175     

Arg Gly Lys Pro Val Ile Ser Ala Leu Ile Val Pro Thr Gly Ile Glu 
            180                 185                 190         

Gly Phe Thr Ile Ser Cys Asn Tyr Asp Lys Met Gly Val Arg Ala Ser 
        195                 200                 205             

Asn Thr Cys Glu Leu Val Leu Glu Asp Val Arg Val Pro Lys Glu Asn 
    210                 215                 220                 

Leu Leu Gly Asp Pro Thr Lys Gly Phe Lys Gln Phe Leu Tyr Thr Leu 
225                 230                 235                 240 

Asp Gly Gly Arg Ile Ser Ile Gly Ala Leu Ala Val Gly Ile Ala Gln 
                245                 250                 255     

Ala Ala Phe Asp Arg Ala Leu Ala Tyr Ala Asn Glu Arg Lys Gln Phe 
            260                 265                 270         

Gly Gln Lys Ile Ser Ser Phe Gln Ala Ile Gln Phe Lys Leu Ala Asp 
        275                 280                 285             

Met Ala Met Glu Ile Glu Leu Ala Arg Asn Met Val Leu Lys Ala Ala 
    290                 295                 300                 

Trp Leu Lys Asp Gln Lys Lys Pro Phe Thr Lys Glu Gly Ala Tyr Ala 
305                 310                 315                 320 

Lys Leu Tyr Ala Ser Glu Thr Ala Met Arg Thr Ala Asn Gln Ala Ile 
                325                 330                 335     

Gln Ile His Gly Gly Tyr Gly Tyr Met Gln Glu Tyr Glu Val Glu Arg 
            340                 345                 350         

Met Leu Arg Asp Ala Lys Leu Leu Glu Ile Gly Glu Gly Thr Ser Glu 
        355                 360                 365             

Ile Gln Arg Met Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375                 380 

<210>   432
<211>   379
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   432
Met Asn Phe Glu Leu Thr Arg Glu Gln Gln Met Ile Arg Glu Leu Ala 
                5                   10                  15      

Arg Asp Phe Ala Lys Gln Glu Ile Ala Pro His Ala Glu His Val Asp 
            20                  25                  30          

Arg Thr Gly Glu Phe Pro Ile Glu Thr Phe Lys Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Leu Leu Gly Ile Pro Phe Pro Glu Ser Tyr Gly Gly Ser Gly Gly 
    50                  55                  60                  

Asp Thr Ile Ser Tyr Ala Leu Ser Val Glu Glu Ile Gly Lys Ala Cys 
65                  70                  75                  80  

Gly Ser Thr Gly Leu Ser Tyr Ala Ala Ala Val Ser Leu Gly Ala Ala 
                85                  90                  95      

Pro Ile Tyr Tyr Phe Gly Thr Glu Glu Gln Lys Gln Glu Tyr Leu Val 
            100                 105                 110         

Pro Leu Ala Thr Gly Arg Ala Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Asn Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Lys Ala Arg Ser Glu 
    130                 135                 140                 

Gly Asp Ser Tyr Val Ile Ser Gly Glu Lys Cys Trp Ile Thr Asn Ala 
145                 150                 155                 160 

Gly Phe Ala Arg Thr Val Ile Val Thr Ala Val Thr Gly Ile Asp Asp 
                165                 170                 175     

Asn Gly Lys Asn Ile Ile Ser Ala Ile Ile Val Pro Thr Asp Ser Glu 
            180                 185                 190         

Gly Phe Thr Ile Lys Ser Glu Tyr Asp Lys Met Gly Val Arg Gly Ser 
        195                 200                 205             

Asn Thr Ser Gln Leu Ile Leu Asp Asn Val Arg Val Pro Lys Gln Asn 
    210                 215                 220                 

Leu Leu Gly Ser Pro Glu Lys Gly Phe Lys Gln Phe Leu Asn Thr Leu 
225                 230                 235                 240 

Asp Gly Gly Arg Ile Ser Ile Ala Ala Leu Ala Val Gly Ile Ala Gln 
                245                 250                 255     

Gly Ala Phe Glu Ala Ala Leu Thr Tyr Ala Arg Glu Arg Lys Gln Phe 
            260                 265                 270         

Gly Arg Pro Ile Ser Tyr Phe Gln Ala Ile Gln Phe Lys Leu Ala Asp 
        275                 280                 285             

Met Ala Met Glu Ile Glu Leu Ala Arg Asn Met Val Leu Lys Ala Ala 
    290                 295                 300                 

Trp Leu Lys Asp Gln Gly Arg Pro Phe Thr Lys Glu Ala Ala Phe Ala 
305                 310                 315                 320 

Lys Leu Tyr Ala Ser Glu Met Ala Phe Arg Thr Cys Asn Gln Ser Ile 
                325                 330                 335     

Gln Ile His Gly Gly Tyr Gly Tyr Met Lys Glu Tyr Gly Val Glu Arg 
            340                 345                 350         

Met Leu Arg Asp Ala Lys Leu Met Glu Ile Gly Glu Gly Thr Ser Glu 
        355                 360                 365             

Ile Gln Arg Leu Val Ile Ala Arg Gln Leu Gly 
    370                 375                 

<210>   433
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   433
Met Asp Phe Asp Leu Thr Ser Glu Gln Lys Met Ile Arg Asp Thr Val 
                5                   10                  15      

Arg Glu Phe Ala Glu Ala Glu Ile Ala Pro His Ala Ala Glu Trp Asp 
            20                  25                  30          

Arg Thr Glu His Phe Pro Ile Glu Val Phe Arg Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Phe Leu Gly Leu Pro Ile Pro Glu Glu Tyr Gly Gly Ala Gly Ala 
    50                  55                  60                  

Asp Met Ile Ser Tyr Cys Leu Ala Val Glu Glu Ile Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Glu Ala His Val Ser Leu Ala Cys Thr 
                85                  90                  95      

Pro Ile Leu Leu Tyr Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu Val 
            100                 105                 110         

Pro Met Ala Arg Gly Glu Ala Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Thr Ala Val Leu Glu 
    130                 135                 140                 

Gly Asp Glu Trp Val Ile Thr Gly Asn Lys Ile Phe Asn Thr Asn Gly 
145                 150                 155                 160 

Gly Tyr Ala Lys Tyr Val Val Leu Thr Ala Val Thr Asp Pro Ala Ser 
                165                 170                 175     

Arg Gly Ile Ser Ala Phe Ile Val Pro Thr Asp Ala Glu Gly Phe Ser 
            180                 185                 190         

Val Ser Arg Pro Tyr Glu Lys Leu Gly Met Arg Ala Ser Asn Thr Val 
        195                 200                 205             

Glu Leu Ile Leu Asp His Val Arg Val Pro Lys Glu Asn Leu Leu Gly 
    210                 215                 220                 

Pro Leu Asn Ala Gly Phe Lys Gln Phe Leu Ser Thr Leu Asp Gly Gly 
225                 230                 235                 240 

Arg Val Ala Ile Ala Ala Leu Ala Val Gly Ile Ala Arg Ala Ala Phe 
                245                 250                 255     

Glu Thr Ala Leu Ala Tyr Ala Lys Thr Arg Val Gln Phe Gly Gln Ala 
            260                 265                 270         

Ile Ser Lys Phe Gln Ala Ile Gln His Lys Leu Ala Asp Met Ala Met 
        275                 280                 285             

His Ile Asp Leu Ala Arg Asn Ala Val Met Lys Ala Ala Trp Leu Lys 
    290                 295                 300                 

Asp Gln Gly Arg Pro Tyr Thr Leu Glu Ala Ser Tyr Ala Lys Leu Phe 
305                 310                 315                 320 

Ala Ser Glu Met Cys Thr Arg Thr Cys Glu Gln Ala Ile Gln Ile Leu 
                325                 330                 335     

Gly Gly Tyr Gly Tyr Met Arg Glu Tyr Pro Val Glu Arg His Tyr Arg 
            340                 345                 350         

Asp Ala Lys Leu Ile Glu Ile Gly Glu Gly Thr Ser Glu Ile Gln Arg 
        355                 360                 365             

Leu Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375         

<210>   434
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   434
Met Asp Phe Asp Leu Thr Ser Glu Gln Lys Met Ile Arg Asp Thr Val 
                5                   10                  15      

Arg Glu Phe Ala Glu Ala Glu Ile Ala Pro His Ala Ala Glu Trp Asp 
            20                  25                  30          

Arg Thr Glu His Phe Pro Ile Glu Val Phe Arg Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Phe Leu Gly Leu Pro Ile Pro Glu Glu Tyr Gly Gly Ala Gly Ala 
    50                  55                  60                  

Asp Met Ile Ser Tyr Cys Leu Ala Val Glu Glu Ile Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Glu Ala His Val Ser Leu Ala Cys Thr 
                85                  90                  95      

Pro Ile Leu Leu Tyr Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu Val 
            100                 105                 110         

Pro Met Ala Arg Gly Glu Ala Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Thr Ala Val Ile Glu 
    130                 135                 140                 

Gly Asp Glu Trp Val Ile Thr Gly Asn Lys Ile Phe Asn Thr Asn Gly 
145                 150                 155                 160 

Gly Tyr Ala Lys Tyr Val Val Leu Thr Ala Val Thr Asp Pro Ala Ser 
                165                 170                 175     

Arg Gly Ile Ser Ala Phe Ile Val Pro Thr Asp Ala Glu Gly Phe Ser 
            180                 185                 190         

Val Ser Lys Pro Tyr Glu Lys Leu Gly Met Arg Ala Ser Asn Thr Val 
        195                 200                 205             

Glu Leu Ile Leu Asp His Val Arg Val Pro Lys Glu Asn Leu Leu Gly 
    210                 215                 220                 

Pro Leu Asn Ala Gly Phe Lys Gln Phe Leu Ser Thr Leu Asp Gly Gly 
225                 230                 235                 240 

Arg Val Ala Ile Ala Ala Leu Ala Val Gly Ile Ala Arg Ala Ala Phe 
                245                 250                 255     

Glu Thr Ala Leu Ala Tyr Ala Lys Thr Arg Val Gln Phe Gly Gln Ala 
            260                 265                 270         

Ile Ser Lys Phe Gln Ala Ile Gln His Lys Leu Ala Asp Met Ala Met 
        275                 280                 285             

His Ile Asp Leu Ala Arg Asn Ala Val Met Lys Ala Ala Trp Leu Lys 
    290                 295                 300                 

Asp Gln Gly Arg Pro Tyr Thr Leu Glu Ala Ser Tyr Ala Lys Leu Phe 
305                 310                 315                 320 

Ala Ser Glu Met Cys Thr Arg Thr Cys Glu Gln Ala Ile Gln Ile Leu 
                325                 330                 335     

Gly Gly Tyr Gly Tyr Met Arg Glu Tyr Pro Val Glu Arg His Tyr Arg 
            340                 345                 350         

Asp Ala Lys Leu Ile Glu Ile Gly Glu Gly Thr Ser Glu Ile Gln Arg 
        355                 360                 365             

Leu Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375         

<210>   435
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   435
Met Asp Phe Asp Leu Thr Ser Glu Gln Lys Met Ile Arg Asp Thr Val 
                5                   10                  15      

Arg Glu Phe Ala Glu Ala Glu Ile Ala Pro His Ala Ala Glu Trp Asp 
            20                  25                  30          

Arg Thr Glu His Phe Pro Ile Glu Val Phe Arg Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Phe Leu Gly Leu Pro Ile Pro Glu Glu Tyr Gly Gly Ala Gly Ala 
    50                  55                  60                  

Asp Met Ile Ser Tyr Cys Leu Ala Val Glu Glu Ile Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Glu Ala His Val Ser Leu Ala Cys Thr 
                85                  90                  95      

Pro Ile Leu Leu Tyr Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu Val 
            100                 105                 110         

Pro Met Ala Arg Gly Glu Ala Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Thr Ala Val Leu Glu 
    130                 135                 140                 

Gly Asp Glu Trp Val Ile Thr Gly Asn Lys Ile Phe Asn Thr Asn Gly 
145                 150                 155                 160 

Gly Tyr Ala Lys Tyr Val Val Leu Thr Ala Val Thr Asp Pro Ala Ser 
                165                 170                 175     

Arg Gly Ile Ser Ala Phe Ile Val Pro Thr Asp Ala Glu Gly Phe Ser 
            180                 185                 190         

Val Ser Lys Pro Tyr Glu Lys Leu Gly Met Arg Ala Ser Asn Thr Ile 
        195                 200                 205             

Glu Leu Ile Leu Asp His Val Arg Val Pro Lys Glu Asn Leu Leu Gly 
    210                 215                 220                 

Pro Leu Asn Ala Gly Phe Lys Gln Phe Leu Ser Thr Leu Asp Gly Gly 
225                 230                 235                 240 

Arg Val Ala Ile Ala Ala Leu Ala Val Gly Ile Ala Arg Ala Ala Phe 
                245                 250                 255     

Glu Thr Ala Leu Ala Tyr Ala Lys Thr Arg Val Gln Phe Gly Gln Ala 
            260                 265                 270         

Ile Ser Lys Phe Gln Ala Ile Gln His Lys Leu Ala Asp Met Ala Met 
        275                 280                 285             

His Ile Asp Leu Ala Arg Asn Ala Val Met Lys Ala Ala Trp Leu Lys 
    290                 295                 300                 

Asp Gln Gly Arg Pro Tyr Thr Leu Glu Ala Ser Tyr Ala Lys Leu Phe 
305                 310                 315                 320 

Ala Ser Glu Met Cys Thr Arg Thr Cys Glu Gln Ala Ile Gln Ile Leu 
                325                 330                 335     

Gly Gly Tyr Gly Tyr Met Arg Glu Tyr Pro Val Glu Arg His Tyr Arg 
            340                 345                 350         

Asp Ala Lys Leu Ile Glu Ile Gly Glu Gly Thr Ser Glu Ile Gln Arg 
        355                 360                 365             

Leu Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375         

<210>   436
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   436
Met Asp Phe Asp Leu Thr Ser Glu Gln Lys Met Ile Arg Asp Thr Val 
                5                   10                  15      

Arg Glu Phe Ala Glu Ala Glu Ile Ala Pro His Ala Ala Glu Trp Asp 
            20                  25                  30          

Arg Thr Glu His Phe Pro Ile Glu Val Phe Arg Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Phe Leu Gly Leu Pro Ile Pro Glu Glu Tyr Gly Gly Ala Gly Ala 
    50                  55                  60                  

Asp Met Ile Ser Tyr Cys Leu Ala Val Glu Glu Ile Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Glu Ala His Val Ser Leu Ala Cys Thr 
                85                  90                  95      

Pro Ile Leu Leu Tyr Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu Val 
            100                 105                 110         

Pro Met Ala Arg Gly Glu Ala Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Thr Ala Val Leu Glu 
    130                 135                 140                 

Gly Asp Glu Trp Val Ile Thr Gly Asn Lys Ile Phe Asn Thr Asn Gly 
145                 150                 155                 160 

Gly Tyr Ala Lys Tyr Val Val Leu Thr Ala Val Thr Asp Pro Ala Ser 
                165                 170                 175     

Arg Gly Ile Ser Ala Phe Ile Val Pro Thr Asp Ala Glu Gly Phe Ser 
            180                 185                 190         

Val Ser Lys Pro Tyr Glu Lys Leu Gly Met Arg Ala Ser Asn Thr Val 
        195                 200                 205             

Glu Leu Ile Leu Asp His Val Arg Val Pro Lys Glu Asn Leu Leu Gly 
    210                 215                 220                 

Pro Ile Asn Ala Gly Phe Lys Gln Phe Leu Ser Thr Leu Asp Gly Gly 
225                 230                 235                 240 

Arg Val Ala Ile Ala Ala Leu Ala Val Gly Ile Ala Arg Ala Ala Phe 
                245                 250                 255     

Glu Thr Ala Leu Ala Tyr Ala Lys Thr Arg Val Gln Phe Gly Gln Ala 
            260                 265                 270         

Ile Ser Lys Phe Gln Ala Ile Gln His Lys Leu Ala Asp Met Ala Met 
        275                 280                 285             

His Ile Asp Leu Ala Arg Asn Ala Val Met Lys Ala Ala Trp Leu Lys 
    290                 295                 300                 

Asp Gln Gly Arg Pro Tyr Thr Leu Glu Ala Ser Tyr Ala Lys Leu Phe 
305                 310                 315                 320 

Ala Ser Glu Met Cys Thr Arg Thr Cys Glu Gln Ala Ile Gln Ile Leu 
                325                 330                 335     

Gly Gly Tyr Gly Tyr Met Arg Glu Tyr Pro Val Glu Arg His Tyr Arg 
            340                 345                 350         

Asp Ala Lys Leu Ile Glu Ile Gly Glu Gly Thr Ser Glu Ile Gln Arg 
        355                 360                 365             

Leu Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375         

<210>   437
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   437
Met Asp Phe Asp Leu Thr Ser Glu Gln Lys Met Ile Arg Asp Thr Val 
                5                   10                  15      

Arg Glu Phe Ala Glu Ala Glu Ile Ala Pro His Ala Ala Glu Trp Asp 
            20                  25                  30          

Arg Thr Glu His Phe Pro Ile Glu Val Phe Arg Lys Met Gly Glu Leu 
        35                  40                  45              

Gly Phe Leu Gly Leu Pro Ile Pro Glu Glu Tyr Gly Gly Ala Gly Ala 
    50                  55                  60                  

Asp Met Ile Ser Tyr Cys Leu Ala Val Glu Glu Ile Gly Arg Ala Cys 
65                  70                  75                  80  

Gly Gly Thr Gly Leu Ser Tyr Glu Ala His Val Ser Leu Ala Cys Thr 
                85                  90                  95      

Pro Ile Leu Leu Tyr Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu Val 
            100                 105                 110         

Pro Met Ala Arg Gly Glu Ala Leu Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Ala Gly Gly Thr Arg Thr Thr Ala Val Leu Glu 
    130                 135                 140                 

Gly Asp Glu Trp Val Ile Thr Gly Asn Lys Leu Phe Asn Thr Asn Gly 
145                 150                 155                 160 

Gly Tyr Ala Lys Tyr Val Val Leu Thr Ala Val Thr Asp Pro Ala Ser 
                165                 170                 175     

Arg Gly Ile Ser Ala Phe Ile Val Pro Thr Asp Ala Glu Gly Phe Ser 
            180                 185                 190         

Val Ser Lys Pro Tyr Glu Lys Leu Gly Met Arg Ala Ser Asn Thr Val 
        195                 200                 205             

Glu Leu Ile Leu Asp His Val Arg Val Pro Lys Glu Asn Leu Leu Gly 
    210                 215                 220                 

Pro Leu Asn Ala Gly Phe Lys Gln Phe Leu Ser Thr Leu Asp Gly Gly 
225                 230                 235                 240 

Arg Val Ala Ile Ala Ala Leu Ala Val Gly Ile Ala Arg Ala Ala Phe 
                245                 250                 255     

Glu Thr Ala Leu Ala Tyr Ala Lys Thr Arg Val Gln Phe Gly Gln Ala 
            260                 265                 270         

Ile Ser Lys Phe Gln Ala Ile Gln His Lys Leu Ala Asp Met Ala Met 
        275                 280                 285             

His Ile Asp Leu Ala Arg Asn Ala Val Met Lys Ala Ala Trp Leu Lys 
    290                 295                 300                 

Asp Gln Gly Arg Pro Tyr Thr Leu Glu Ala Ser Tyr Ala Lys Leu Phe 
305                 310                 315                 320 

Ala Ser Glu Met Cys Thr Arg Thr Cys Glu Gln Ala Ile Gln Ile Leu 
                325                 330                 335     

Gly Gly Tyr Gly Tyr Met Arg Glu Tyr Pro Val Glu Arg His Tyr Arg 
            340                 345                 350         

Asp Ala Lys Leu Ile Glu Ile Gly Glu Gly Thr Ser Glu Ile Gln Arg 
        355                 360                 365             

Leu Val Ile Ala Arg Gln Leu Gly Cys 
    370                 375         

<210>   438
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   438
gtggactttg atctcacctc ggaacaaaag atgattcggg atacggtgcg cgagtttgcg       60

gaggccgaga tcgcgcctca cgccgcggaa tgggatagga cggagcactt ccccatcgag      120

gtgtttcgca agatgggcga actcggcttt ctcggcctgc ccattccgga ggaatacggt      180

ggcgcgggcg ccgacatgat ctcgtactgc ctggcggtgg aggagatcgg gcgcgcgtgc      240

ggcggaacag ggctcagcta cgaggcgcac gtgtcgctcg cgtgcacgcc cattctgctc      300

tacgggacgg aggagcagaa acagaagtac ctggtgccta tggcgcgcgg cgaggcgctc      360

ggtgcgtttg gtttgacgga gcccggggct ggatcggacg ccggaggaac gcggacgacc      420

gccgtcctgg agggcgacga atgggtcatc accggcaaca agatcttcaa cacaaacggc      480

ggctatgcga agtacgtcgt gctcaccgcg gtgacggatc cggcgtcgcg cggcatcagc      540

gcgttcatcg tgccgacaga tgccgagggc ttctcggtga gccgtccgta tgagaaactg      600

ggcatgcggg cgtcgaacac ggtcgaactg attctcgatc acgtccgcgt tccgaaggag      660

aacctactcg ggccgctgaa cgctgggttc aagcagtttc tctcgacgct ggacggcgga      720

cgtgtcgcca tcgcagctct ggcggtcggg atcgcgcggg cggcgtttga gacggctctc      780

gcgtacgcca agacgcgcgt ccagttcggg caggccatca gcaagttcca ggcgattcag      840

cacaagctcg ccgacatggc catgcacatc gatctcgccc ggaatgcggt gatgaaggcc      900

gcgtggctga aggatcaggg ccggccgtac acgctggagg cgtcgtacgc caagctgttt      960

gcgtccgaga tgtgcacgcg gacgtgcgag caggcgattc agatcttggg cgggtatggc     1020

tacatgcgcg aatacccggt ggagcgccac tatcgcgacg cgaagttgat cgagatcggc     1080

gagggcacgt cggagatcca gcgcctggtg atcgcgcgcc agctgggctg ttag           1134


<210>   439
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   439
gtggactttg atctcacctc ggaacaaaag atgattcggg atacggtgcg cgagtttgcg       60

gaggccgaga tcgcgcctca cgccgcggaa tgggatagga cggagcactt ccccatcgag      120

gtgtttcgca agatgggcga actcggcttt ctcggcctgc ccattccgga ggaatacggt      180

ggcgcgggcg ccgacatgat ctcgtactgc ctggcggtgg aggagatcgg gcgcgcgtgc      240

ggcggaacag ggctcagcta cgaggcgcac gtgtcgctcg cgtgcacgcc cattctgctc      300

tacgggacgg aggagcagaa acagaagtac ctggtgccta tggcgcgcgg cgaggcgctc      360

ggtgcgtttg gtttgacgga gcccggggct ggatcggacg ccggaggaac gcggacgacc      420

gccgtcattg agggcgacga atgggtcatc accggcaaca agatcttcaa cacaaacggc      480

ggctatgcga agtacgtcgt gctcaccgcg gtgacggatc cggcgtcgcg cggcatcagc      540

gcgttcatcg tgccgacaga tgccgagggc ttctcggtga gcaagccgta tgagaaactg      600

ggcatgcggg cgtcgaacac ggtcgaactg attctcgatc acgtccgcgt tccgaaggag      660

aacctactcg ggccgctgaa cgctgggttc aagcagtttc tctcgacgct ggacggcgga      720

cgtgtcgcca tcgcagctct ggcggtcggg atcgcgcggg cggcgtttga gacggctctc      780

gcgtacgcca agacgcgcgt ccagttcggg caggccatca gcaagttcca ggcgattcag      840

cacaagctcg ccgacatggc catgcacatc gatctcgccc ggaatgcggt gatgaaggcc      900

gcgtggctga aggatcaggg ccggccgtac acgctggagg cgtcgtacgc caagctgttt      960

gcgtccgaga tgtgcacgcg gacgtgcgag caggcgattc agatcttggg cgggtatggc     1020

tacatgcgcg aatacccggt ggagcgccac tatcgcgacg cgaagttgat cgagatcggc     1080

gagggcacgt cggagatcca gcgcctggtg atcgcgcgcc agctgggctg ttag           1134


<210>   440
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   440
gtggactttg atctcacctc ggaacaaaag atgattcggg atacggtgcg cgagtttgcg       60

gaggccgaga tcgcgcctca cgccgcggaa tgggatagga cggagcactt ccccatcgag      120

gtgtttcgca agatgggcga actcggcttt ctcggcctgc ccattccgga ggaatacggt      180

ggcgcgggcg ccgacatgat ctcgtactgc ctggcggtgg aggagatcgg gcgcgcgtgc      240

ggcggaacag ggctcagcta cgaggcgcac gtgtcgctcg cgtgcacgcc cattctgctc      300

tacgggacgg aggagcagaa acagaagtac ctggtgccta tggcgcgcgg cgaggcgctc      360

ggtgcgtttg gtttgacgga gcccggggct ggatcggacg ccggaggaac gcggacgacc      420

gccgtcctgg agggcgacga atgggtcatc accggcaaca agatcttcaa cacaaacggc      480

ggctatgcga agtacgtcgt gctcaccgcg gtgacggatc cggcgtcgcg cggcatcagc      540

gcgttcatcg tgccgacaga tgccgagggc ttctcggtga gcaagccgta tgagaaactg      600

ggcatgcggg cgtcgaacac gattgaactg attctcgatc acgtccgcgt tccgaaggag      660

aacctactcg ggccgctgaa cgctgggttc aagcagtttc tctcgacgct ggacggcgga      720

cgtgtcgcca tcgcagctct ggcggtcggg atcgcgcggg cggcgtttga gacggctctc      780

gcgtacgcca agacgcgcgt ccagttcggg caggccatca gcaagttcca ggcgattcag      840

cacaagctcg ccgacatggc catgcacatc gatctcgccc ggaatgcggt gatgaaggcc      900

gcgtggctga aggatcaggg ccggccgtac acgctggagg cgtcgtacgc caagctgttt      960

gcgtccgaga tgtgcacgcg gacgtgcgag caggcgattc agatcttggg cgggtatggc     1020

tacatgcgcg aatacccggt ggagcgccac tatcgcgacg cgaagttgat cgagatcggc     1080

gagggcacgt cggagatcca gcgcctggtg atcgcgcgcc agctgggctg ttag           1134


<210>   441
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   441
gtggactttg atctcacctc ggaacaaaag atgattcggg atacggtgcg cgagtttgcg       60

gaggccgaga tcgcgcctca cgccgcggaa tgggatagga cggagcactt ccccatcgag      120

gtgtttcgca agatgggcga actcggcttt ctcggcctgc ccattccgga ggaatacggt      180

ggcgcgggcg ccgacatgat ctcgtactgc ctggcggtgg aggagatcgg gcgcgcgtgc      240

ggcggaacag ggctcagcta cgaggcgcac gtgtcgctcg cgtgcacgcc cattctgctc      300

tacgggacgg aggagcagaa acagaagtac ctggtgccta tggcgcgcgg cgaggcgctc      360

ggtgcgtttg gtttgacgga gcccggggct ggatcggacg ccggaggaac gcggacgacc      420

gccgtcctgg agggcgacga atgggtcatc accggcaaca agatcttcaa cacaaacggc      480

ggctatgcga agtacgtcgt gctcaccgcg gtgacggatc cggcgtcgcg cggcatcagc      540

gcgttcatcg tgccgacaga tgccgagggc ttctcggtga gcaagccgta tgagaaactg      600

ggcatgcggg cgtcgaacac ggtcgaactg attctcgatc acgtccgcgt tccgaaggag      660

aacctactcg ggccgattaa cgctgggttc aagcagtttc tctcgacgct ggacggcgga      720

cgtgtcgcca tcgcagctct ggcggtcggg atcgcgcggg cggcgtttga gacggctctc      780

gcgtacgcca agacgcgcgt ccagttcggg caggccatca gcaagttcca ggcgattcag      840

cacaagctcg ccgacatggc catgcacatc gatctcgccc ggaatgcggt gatgaaggcc      900

gcgtggctga aggatcaggg ccggccgtac acgctggagg cgtcgtacgc caagctgttt      960

gcgtccgaga tgtgcacgcg gacgtgcgag caggcgattc agatcttggg cgggtatggc     1020

tacatgcgcg aatacccggt ggagcgccac tatcgcgacg cgaagttgat cgagatcggc     1080

gagggcacgt cggagatcca gcgcctggtg atcgcgcgcc agctgggctg ttag           1134


<210>   442
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   442
gtggactttg atctcacctc ggaacaaaag atgattcggg atacggtgcg cgagtttgcg       60

gaggccgaga tcgcgcctca cgccgcggaa tgggatagga cggagcactt ccccatcgag      120

gtgtttcgca agatgggcga actcggcttt ctcggcctgc ccattccgga ggaatacggt      180

ggcgcgggcg ccgacatgat ctcgtactgc ctggcggtgg aggagatcgg gcgcgcgtgc      240

ggcggaacag ggctcagcta cgaggcgcac gtgtcgctcg cgtgcacgcc cattctgctc      300

tacgggacgg aggagcagaa acagaagtac ctggtgccta tggcgcgcgg cgaggcgctc      360

ggtgcgtttg gtttgacgga gcccggggct ggatcggacg ccggaggaac gcggacgacc      420

gccgtcctgg agggcgacga atgggtcatc accggcaaca agttattcaa cacaaacggc      480

ggctatgcga agtacgtcgt gctcaccgcg gtgacggatc cggcgtcgcg cggcatcagc      540

gcgttcatcg tgccgacaga tgccgagggc ttctcggtga gcaagccgta tgagaaactg      600

ggcatgcggg cgtcgaacac ggtcgaactg attctcgatc acgtccgcgt tccgaaggag      660

aacctactcg ggccgctgaa cgctgggttc aagcagtttc tctcgacgct ggacggcgga      720

cgtgtcgcca tcgcagctct ggcggtcggg atcgcgcggg cggcgtttga gacggctctc      780

gcgtacgcca agacgcgcgt ccagttcggg caggccatca gcaagttcca ggcgattcag      840

cacaagctcg ccgacatggc catgcacatc gatctcgccc ggaatgcggt gatgaaggcc      900

gcgtggctga aggatcaggg ccggccgtac acgctggagg cgtcgtacgc caagctgttt      960

gcgtccgaga tgtgcacgcg gacgtgcgag caggcgattc agatcttggg cgggtatggc     1020

tacatgcgcg aatacccggt ggagcgccac tatcgcgacg cgaagttgat cgagatcggc     1080

gagggcacgt cggagatcca gcgcctggtg atcgcgcgcc agctgggctg ttag           1134


<210>   443
<211>   260
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   443
Met Glu Gln Pro Ile Val Trp Gln Lys Ala Glu Asp Gly Ile Ala Glu 
                5                   10                  15      

Leu Leu Leu Asn Arg Pro Asp Ala Met Asn Ala Leu Asn Tyr Ala Leu 
            20                  25                  30          

Leu Arg Ala Leu Glu Asp Ala Val Arg Glu Ile Ala Glu Asp Arg Gly 
        35                  40                  45              

Val Arg Ala Val Ile Val Arg Gly Glu Gly Lys Gly Phe Cys Ala Gly 
    50                  55                  60                  

Ala Asp Leu Lys Glu Arg Arg Gly Leu Ala Pro His Glu Val Arg Arg 
65                  70                  75                  80  

Asn Val Arg Leu Thr Arg Glu Ala Phe Asp Arg Val Ala Arg Leu Pro 
                85                  90                  95      

Gln Pro Thr Ile Ala Val Leu His Gly Phe Ala Phe Gly Gly Gly Leu 
            100                 105                 110         

Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Gly Ser Arg Asp Leu Arg 
        115                 120                 125             

Leu Gly Leu Thr Glu Thr Ser Leu Ala Ile Val Pro Gly Ala Gly Gly 
    130                 135                 140                 

Thr Gln Arg Leu Ala Arg Leu Ile Gly Pro Thr Trp Ala Lys Trp Met 
145                 150                 155                 160 

Ile Phe Thr Ala Ala Arg Ile Asp Ala Glu Arg Ala Arg Glu Leu Gly 
                165                 170                 175     

Ile Leu Leu Glu Val Ala Asp Thr Arg Glu Ala Ala Met Asp Ala Ala 
            180                 185                 190         

Arg Ala Leu Ala Arg Ala Ile Ala Glu Asn Gly Pro Val Ala Val Arg 
        195                 200                 205             

Gln Ala Lys Trp Ala Ile Asp Arg Gly Leu Asp Val Asp Leu Ser Thr 
    210                 215                 220                 

Gly Leu Ala Ile Glu Asp Ala Ala Tyr Glu Gly Val Leu Pro Thr Ser 
225                 230                 235                 240 

Asp Arg Leu Glu Ala Leu Ala Ala Phe Ala Glu Lys Arg Lys Pro His 
                245                 250                 255     

Phe Arg Gly Glu 
            260 

<210>   444
<211>   783
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   444
gtggaacagc cgattgtgtg gcagaaggcg gaggacggga tcgcggagct cctcctgaat       60

cggccggatg cgatgaacgc gctcaattac gcgctgctcc gcgcgctgga agatgccgtg      120

cgcgagatcg cggaggaccg cggcgtgcgt gccgtgatcg tgcgcgggga gggaaaggga      180

ttctgcgcgg gagcggattt gaaggaacgg cgcggcctgg cgcctcacga agtgcggcgc      240

aacgtgcgct tgacgcgcga ggcgttcgat cgcgtcgcgc gcctgccgca gccgaccatc      300

gcggtcctgc atggattcgc gttcggaggc gggctggagc tggcgctggc gtgcgacttt      360

cgcatcggca gtcgcgatct tcggctcggt ctgacggaga cgtcgctcgc catcgtccct      420

ggggcgggcg ggacgcagcg gctggcccgc ctcatcgggc cgacgtgggc caagtggatg      480

atcttcacgg ccgcgcgcat cgacgcggag cgcgcgagag agctcggcat cctgctcgag      540

gtggcggata cccgagaggc cgcgatggac gccgcgcgag cgctggcccg cgccatcgcc      600

gaaaacgggc cggtcgcggt gcgccaggcg aagtgggcca tcgatcgcgg cctggacgtc      660

gatctgtcga cggggcttgc catcgaggat gcggcgtatg agggcgttct gccgacctcg      720

gatcggctgg aggcgctcgc ggcgttcgcg gaaaagcgca agccgcactt ccgcggtgaa      780

tag                                                                    783


<210>   445
<211>   249
<212>   PRT
<213>   Exiguobacterium sibiricum 255-15

<400>   445
Asp His Val Ala Val Ile Arg Val Asp Arg Pro Glu Arg Leu Asn Cys 
                5                   10                  15      

Phe Asp Tyr Pro Thr Leu Val Glu Leu Lys Glu Leu Val Ala Thr Val 
            20                  25                  30          

Arg Arg Glu Pro Asp Ile Arg Val Val Leu Phe Thr Gly Thr Gly Lys 
        35                  40                  45              

Ala Phe Ser Ala Gly Ala Asp Leu Lys Glu Arg Val Thr Leu Asn Glu 
    50                  55                  60                  

Thr Glu Val Arg Arg Asn Val Glu Met Ile Arg Asp Val Phe Ala Asp 
65                  70                  75                  80  

Ile Ala Arg Leu Pro Gln Pro Thr Ile Ala Ala Val Asn Gly His Ala 
                85                  90                  95      

Leu Gly Gly Gly Phe Glu Trp Met Leu Ala Cys Asp Phe Arg Ile Ile 
            100                 105                 110         

Val Asn Gly Ala Leu Val Gly Leu Thr Glu Thr Ser Phe Gly Ile Ile 
        115                 120                 125             

Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Arg Leu Ile Gly Glu Thr 
    130                 135                 140                 

Arg Ala Lys Glu Met Ile Phe Thr Ala Lys Lys Ile Asp Ala Glu Thr 
145                 150                 155                 160 

Ala Glu Arg Tyr Gly Ile Val Ser Arg Val Val Pro Thr Val Glu Glu 
                165                 170                 175     

Leu Met Glu Val Cys Leu Ala Phe Ala Asp Glu Met Leu Arg Asn Gly 
            180                 185                 190         

Pro Ile Ala Ile Arg Gln Ala Lys Gln Ala Ile Asp Gln Gly Leu Asp 
        195                 200                 205             

His Thr Leu Ser Glu Gly Leu Lys Leu Glu Thr Ala Ala Tyr Glu Thr 
    210                 215                 220                 

Val Ile Pro Thr Glu Asp Arg Leu Glu Ala Leu Arg Ala Phe Ala Glu 
225                 230                 235                 240 

Lys Arg Thr Pro Gln Phe Gln Gly Lys 
                245                 

<210>   446
<211>   260
<212>   PRT
<213>   Desulfatibacillum alkenivorans AK-01

<400>   446
Met Glu Glu Glu Leu Val Leu Ser Gln Thr Glu Asp Gln Val Leu Thr 
                5                   10                  15      

Leu Thr Leu Asn Arg Pro Lys Val Met Asn Ser Phe Asn Phe Ala Met 
            20                  25                  30          

Leu His Ala Leu Lys Ala Ala Val Asp Lys Ala Arg Phe Asp Pro Glu 
        35                  40                  45              

Val Arg Val Ile Ile Ile Thr Gly Ala Gly Asp Arg Ala Phe Cys Ala 
    50                  55                  60                  

Gly Ala Asp Leu Lys Glu Arg Ala Thr Leu Thr Pro Val Gln Val Lys 
65                  70                  75                  80  

Glu Phe Ile Tyr Thr Ile Arg Asn Leu Phe Thr Asp Ile Glu Asn Leu 
                85                  90                  95      

Pro Lys Pro Val Ile Ala Ala Val Asn Gly Ile Ala Leu Gly Gly Gly 
            100                 105                 110         

Thr Glu Leu Ala Leu Gly Cys Asp Ile Arg Leu Ala Ala Glu Thr Ala 
        115                 120                 125             

Ala Met Gly Leu Thr Glu Thr Thr Leu Ala Ile Ile Pro Gly Ala Gly 
    130                 135                 140                 

Gly Thr Gln Arg Leu Pro Arg Leu Ile Gly Lys Gly Lys Ala Lys Glu 
145                 150                 155                 160 

Leu Ile Phe Thr Gly Arg Arg Val Asp Ala Gln Glu Ala Leu Asp Leu 
                165                 170                 175     

Gly Met Val Asn Lys Val Val Pro Gly Asp Ser Leu Leu Asp Ala Ala 
            180                 185                 190         

Lys Asp Met Ala Ala Ala Ile Arg Lys Asn Gly Pro Ile Ala Val Thr 
        195                 200                 205             

Gln Ala Lys Tyr Ala Ile Asn Gln Gly Met Glu Thr Asp Leu Ser Thr 
    210                 215                 220                 

Gly Leu Ala Ile Glu Ser Asn Ala Tyr Trp Ile Thr Ile Pro Ser Lys 
225                 230                 235                 240 

Asp Arg Leu Glu Gly Leu Ala Ala Phe Arg Glu Lys Arg Lys Pro Val 
                245                 250                 255     

Tyr Lys Gly Glu 
            260 

<210>   447
<211>   255
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   447
Val Leu Gln Thr Ile Lys Asn His Val Ala Ile Ile Thr Phe Asn Arg 
                5                   10                  15      

Pro Asp Gln Leu Asn Cys Phe Asn Tyr Gln Met Leu Leu Asp Leu Glu 
            20                  25                  30          

Gln Val Ile Gln Glu Val Lys Ala Asn Pro Ala Ile Arg Thr Val Ile 
        35                  40                  45              

Phe Thr Gly Ala Gly Gly Lys Ser Phe Ser Ala Gly Ala Asp Leu Lys 
    50                  55                  60                  

Glu Arg Arg Thr Leu Asp Glu Asn Gln Val Arg Arg Asn Val Asn Lys 
65                  70                  75                  80  

Ile Arg Ser Val Phe Asn Gln Ile Glu Glu Leu Pro Gln Pro Thr Ile 
                85                  90                  95      

Ala Ala Ile Asn Gly Tyr Ala Leu Gly Gly Gly Phe Glu Leu Ala Leu 
            100                 105                 110         

Ala Cys Asp Phe Arg Leu Ala Val Pro Glu Ala Lys Met Gly Leu Thr 
        115                 120                 125             

Glu Val Thr Trp Ala Ile Ile Pro Gly Ala Gly Gly Thr Gln Arg Leu 
    130                 135                 140                 

Pro Arg Leu Ile Gly Ser Gln Arg Ala Lys Glu Met Ile Leu Thr Gly 
145                 150                 155                 160 

Arg Lys Val Ala Ala Glu Glu Ala Gln Arg Leu Gly Ile Ile Leu Glu 
                165                 170                 175     

Val Cys Asp Ser Lys His Leu Leu Thr Glu Ala Val Arg Leu Ala Glu 
            180                 185                 190         

Lys Met Ser Val Asn Gly Pro Leu Ala Val Ile Gln Ala Lys Tyr Ala 
        195                 200                 205             

Ile His Tyr Gly Cys Gln Thr Asp Leu His Thr Gly Leu Ala Ile Glu 
    210                 215                 220                 

Ala Lys Ala Tyr Glu Thr Ile Ile Pro Thr Glu Asp Arg Leu Glu Ala 
225                 230                 235                 240 

Leu Gln Ala Phe Lys Glu Lys Arg Pro Pro Gln Phe Lys Gly Lys 
                245                 250                 255 

<210>   448
<211>   249
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   448
Gln Asp Gly Ile Ala Val Met Thr Leu Asn Arg Ser Glu Ala Ala Asn 
                5                   10                  15      

Ala Leu Ser Lys Glu Met Leu Ser Asp Met His Glu Val Leu Ser Glu 
            20                  25                  30          

Ile Lys Lys Asp Arg Ser Thr Arg Val Val Ile Leu Thr Gly Ala Gly 
        35                  40                  45              

Glu Lys Val Phe Cys Ala Gly Ala Asp Leu Lys Glu Arg Lys Gly Met 
    50                  55                  60                  

Asn Glu Glu Glu Val Leu Gln Ala Val Arg Lys Ile Gly Ala Val Val 
65                  70                  75                  80  

Asn Glu Thr Ala Ala Leu Pro Gln Pro Val Ile Ala Ala Leu Asn Gly 
                85                  90                  95      

Ser Ala Phe Gly Gly Gly Leu Glu Leu Ala Leu Ala Cys Asp Leu Arg 
            100                 105                 110         

Ile Gly Ala Arg Glu Ala Lys Tyr Gly Leu Thr Glu Thr Ser Leu Ala 
        115                 120                 125             

Ile Ile Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Arg Leu Ile Gly 
    130                 135                 140                 

Val Gly Lys Ala Lys Glu Leu Ile Tyr Thr Ala Arg Arg Leu Thr Ala 
145                 150                 155                 160 

Glu Glu Ala Ala Ala Ile Gly Leu Leu Glu Tyr Ala Val Pro Arg Ala 
                165                 170                 175     

Ala Val Ile Glu Lys Ala Phe Glu Leu Ala Gly Glu Met Gln Lys Asn 
            180                 185                 190         

Gly Pro Ile Ala Leu Arg Gln Ala Lys Thr Ala Ile Asp Gln Gly Thr 
        195                 200                 205             

Glu Thr Gly Leu Ser Ala Gly Leu Lys Ile Glu Glu Leu Ala Tyr Asn 
    210                 215                 220                 

Ala Leu Ile Pro Thr Glu Asp Arg Leu Glu Gly Leu Arg Ala Phe Ala 
225                 230                 235                 240 

Glu Lys Arg Thr Pro Val Tyr Lys Gly 
                245                 

<210>   449
<211>   255
<212>   PRT
<213>   Bacillus halodurans

<400>   449
Val Leu Gln Thr Ile Lys Asn His Val Ala Ile Ile Thr Phe Asn Arg 
                5                   10                  15      

Pro Asp Gln Leu Asn Cys Phe Asn Tyr Gln Met Leu Leu Asp Leu Glu 
            20                  25                  30          

Gln Val Ile Gln Glu Val Lys Ala Asn Pro Ala Ile Arg Thr Val Ile 
        35                  40                  45              

Phe Thr Gly Ala Gly Gly Lys Ser Phe Ser Ala Gly Ala Asp Leu Lys 
    50                  55                  60                  

Glu Arg Arg Thr Leu Asp Glu Asn Gln Val Arg Arg Asn Val Asn Lys 
65                  70                  75                  80  

Ile Arg Ser Val Phe Asn Gln Ile Glu Glu Leu Pro Gln Pro Thr Ile 
                85                  90                  95      

Ala Ala Ile Asn Gly Tyr Ala Leu Gly Gly Gly Phe Glu Leu Ala Leu 
            100                 105                 110         

Ala Cys Asp Phe Arg Leu Ala Val Pro Glu Ala Lys Met Gly Leu Thr 
        115                 120                 125             

Glu Val Thr Trp Ala Ile Ile Ser Gly Ala Gly Gly Thr Gln Arg Leu 
    130                 135                 140                 

Pro Arg Leu Ile Gly Ser Gln Arg Ala Lys Glu Met Ile Leu Thr Gly 
145                 150                 155                 160 

Arg Lys Val Ala Ala Glu Glu Ala Gln Arg Leu Gly Ile Ile Leu Glu 
                165                 170                 175     

Val Cys Asp Ser Lys His Leu Leu Thr Glu Ala Val Arg Leu Ala Glu 
            180                 185                 190         

Lys Met Ser Val Asn Gly Pro Leu Ala Val Ile Gln Ala Lys Tyr Ala 
        195                 200                 205             

Ile His Tyr Gly Cys Gln Thr Asp Leu His Thr Gly Leu Ala Ile Glu 
    210                 215                 220                 

Ala Lys Ala Tyr Glu Thr Ile Ile Pro Thr Glu Asp Arg Leu Glu Ala 
225                 230                 235                 240 

Leu Gln Ala Phe Lys Glu Lys Arg Pro Pro Gln Phe Lys Gly Lys 
                245                 250                 255 

<210>   450
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   450
Met Glu Gln Pro Ile Val Trp Gln Lys Ala Glu Asp Gly Ile Ala Glu 
                5                   10                  15      

Leu Leu Leu Asn Arg Pro Asp Ala Met Asn Ala Leu Asn Tyr Ala Leu 
            20                  25                  30          

Leu Arg Ala Leu Glu Asp Ala Val Arg Glu Ile Ala Glu Asp Arg Gly 
        35                  40                  45              

Val Arg Ala Val Ile Val Arg Gly Glu Gly Lys Gly Phe Cys Ala Gly 
    50                  55                  60                  

Ala Asp Leu Lys Glu Arg Arg Gly Leu Ala Pro His Glu Val Arg Arg 
65                  70                  75                  80  

Asn Val Arg Leu Thr Arg Glu Ala Phe Asp Arg Val Ala Arg Leu Pro 
                85                  90                  95      

Gln Pro Thr Ile Ala Val Leu His Gly Phe Ala Phe Gly Gly Gly Leu 
            100                 105                 110         

Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Gly Ser Arg Asp Leu Arg 
        115                 120                 125             

Leu Gly Leu Thr Glu Thr Ser Leu Ala Ile Val Pro Gly Ala Gly Gly 
    130                 135                 140                 

Thr Gln Arg Leu Ala Arg Leu Ile Gly Pro Thr Trp Ala Lys Trp Met 
145                 150                 155                 160 

Ile Phe Thr Ala Ala Arg Ile Asp Ala Glu Arg Ala Arg Glu Leu Gly 
                165                 170                 175     

Ile Leu Leu Glu Val Ala Asp Thr Arg Glu Ala Ala Met Asp Ala Ala 
            180                 185                 190         

Arg Ala Leu Ala Arg Ala Ile Ala Glu Asn Gly Pro Val Ala Val Arg 
        195                 200                 205             

Gln Ala Lys Trp Ala Ile Asp Arg Gly Leu Asp Val Asp Leu Ser Thr 
    210                 215                 220                 

Gly Leu Ala Ile Glu Asp Ala Ala Tyr Glu Gly Val Leu Pro Thr Ser 
225                 230                 235                 240 

Asp Arg Leu Glu Ala Leu Ala Ala Phe Ala Glu Lys Arg Lys Pro His 
                245                 250                 255     

Phe Arg Gly Asp 
            260 

<210>   451
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   451
Met Glu Gln Pro Ile Val Trp Gln Lys Ala Glu Asp Gly Ile Ala Glu 
                5                   10                  15      

Leu Leu Leu Asn Arg Pro Asp Ala Met Asn Ala Leu Asn Tyr Ala Leu 
            20                  25                  30          

Leu Arg Ala Leu Glu Asp Ala Val Arg Glu Ile Ala Glu Asp Arg Gly 
        35                  40                  45              

Val Arg Ala Val Ile Val Arg Gly Glu Gly Lys Gly Phe Cys Ala Gly 
    50                  55                  60                  

Ala Asp Leu Lys Glu Arg Arg Gly Leu Ala Pro His Glu Val Arg Arg 
65                  70                  75                  80  

Asn Val Arg Leu Thr Arg Glu Ala Phe Asp Arg Val Ala Arg Leu Pro 
                85                  90                  95      

Gln Pro Thr Ile Ala Val Leu His Gly Phe Ala Phe Gly Gly Gly Leu 
            100                 105                 110         

Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Gly Ser Arg Asp Leu Arg 
        115                 120                 125             

Leu Gly Leu Thr Glu Thr Ser Ile Ala Ile Val Pro Gly Ala Gly Gly 
    130                 135                 140                 

Thr Gln Arg Leu Ala Arg Leu Ile Gly Pro Thr Trp Ala Lys Trp Met 
145                 150                 155                 160 

Ile Phe Thr Ala Ala Arg Ile Asp Ala Glu Arg Ala Arg Glu Leu Gly 
                165                 170                 175     

Ile Leu Leu Glu Val Ala Asp Thr Arg Glu Ala Ala Met Asp Ala Ala 
            180                 185                 190         

Arg Ala Leu Ala Arg Ala Ile Ala Glu Asn Gly Pro Val Ala Val Arg 
        195                 200                 205             

Gln Ala Lys Trp Ala Ile Asp Arg Gly Leu Asp Val Asp Leu Ser Thr 
    210                 215                 220                 

Gly Leu Ala Ile Glu Asp Ala Ala Tyr Glu Gly Val Leu Pro Thr Ser 
225                 230                 235                 240 

Asp Arg Leu Glu Ala Leu Ala Ala Phe Ala Glu Lys Arg Lys Pro His 
                245                 250                 255     

Phe Arg Gly Glu 
            260 

<210>   452
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   452
Met Glu Gln Pro Ile Val Trp Gln Lys Ala Glu Asp Gly Ile Ala Glu 
                5                   10                  15      

Leu Leu Leu Asn Arg Pro Asp Ala Met Asn Ala Leu Asn Tyr Ala Leu 
            20                  25                  30          

Leu Arg Ala Leu Glu Asp Ala Val Arg Glu Ile Ala Glu Asp Arg Gly 
        35                  40                  45              

Val Arg Ala Val Ile Val Arg Gly Glu Gly Lys Gly Phe Cys Ala Gly 
    50                  55                  60                  

Ala Asp Leu Lys Glu Arg Arg Gly Leu Ala Pro His Glu Val Arg Arg 
65                  70                  75                  80  

Asn Val Arg Leu Thr Arg Glu Ala Phe Asp Arg Val Ala Arg Leu Pro 
                85                  90                  95      

Gln Pro Thr Ile Ala Val Leu His Gly Phe Ala Phe Gly Gly Gly Leu 
            100                 105                 110         

Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Gly Ser Arg Glu Leu Arg 
        115                 120                 125             

Leu Gly Leu Thr Glu Thr Ser Leu Ala Ile Val Pro Gly Ala Gly Gly 
    130                 135                 140                 

Thr Gln Arg Leu Ala Arg Leu Ile Gly Pro Thr Trp Ala Lys Trp Met 
145                 150                 155                 160 

Ile Phe Thr Ala Ala Arg Ile Asp Ala Glu Arg Ala Arg Glu Leu Gly 
                165                 170                 175     

Ile Leu Leu Glu Val Ala Asp Thr Arg Glu Ala Ala Met Asp Ala Ala 
            180                 185                 190         

Arg Ala Leu Ala Arg Ala Ile Ala Glu Asn Gly Pro Val Ala Val Arg 
        195                 200                 205             

Gln Ala Lys Trp Ala Ile Asp Arg Gly Leu Asp Val Asp Leu Ser Thr 
    210                 215                 220                 

Gly Leu Ala Ile Glu Asp Ala Ala Tyr Glu Gly Val Leu Pro Thr Ser 
225                 230                 235                 240 

Asp Arg Leu Glu Ala Leu Ala Ala Phe Ala Glu Lys Arg Lys Pro His 
                245                 250                 255     

Phe Arg Gly Glu 
            260 

<210>   453
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   453
Met Glu Gln Pro Ile Val Trp Gln Lys Ala Glu Asp Gly Ile Ala Glu 
                5                   10                  15      

Leu Leu Leu Asn Arg Pro Asp Ala Met Asn Ala Leu Asn Tyr Ala Leu 
            20                  25                  30          

Leu Arg Ala Leu Glu Asp Ala Val Arg Glu Ile Ala Glu Asp Arg Gly 
        35                  40                  45              

Val Arg Ala Val Ile Val Arg Gly Glu Gly Lys Gly Phe Cys Ala Gly 
    50                  55                  60                  

Ala Asp Leu Lys Glu Arg Arg Gly Leu Ala Pro His Glu Val Arg Arg 
65                  70                  75                  80  

Asn Val Arg Leu Thr Arg Asp Ala Phe Asp Arg Val Ala Arg Leu Pro 
                85                  90                  95      

Gln Pro Thr Ile Ala Val Leu His Gly Phe Ala Phe Gly Gly Gly Leu 
            100                 105                 110         

Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Gly Ser Arg Asp Leu Arg 
        115                 120                 125             

Leu Gly Leu Thr Glu Thr Ser Leu Ala Ile Val Pro Gly Ala Gly Gly 
    130                 135                 140                 

Thr Gln Arg Leu Ala Arg Leu Ile Gly Pro Thr Trp Ala Lys Trp Met 
145                 150                 155                 160 

Ile Phe Thr Ala Ala Arg Ile Asp Ala Glu Arg Ala Arg Glu Leu Gly 
                165                 170                 175     

Ile Leu Leu Glu Val Ala Asp Thr Arg Glu Ala Ala Met Asp Ala Ala 
            180                 185                 190         

Arg Ala Leu Ala Arg Ala Ile Ala Glu Asn Gly Pro Val Ala Val Arg 
        195                 200                 205             

Gln Ala Lys Trp Ala Ile Asp Arg Gly Leu Asp Val Asp Leu Ser Thr 
    210                 215                 220                 

Gly Leu Ala Ile Glu Asp Ala Ala Tyr Glu Gly Val Leu Pro Thr Ser 
225                 230                 235                 240 

Asp Arg Leu Glu Ala Leu Ala Ala Phe Ala Glu Lys Arg Lys Pro His 
                245                 250                 255     

Phe Arg Gly Glu 
            260 

<210>   454
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   454
Met Glu Gln Pro Leu Val Trp Gln Lys Ala Glu Asp Gly Ile Ala Glu 
                5                   10                  15      

Leu Leu Leu Asn Arg Pro Asp Ala Met Asn Ala Leu Asn Tyr Ala Leu 
            20                  25                  30          

Leu Arg Ala Leu Glu Asp Ala Val Arg Glu Ile Ala Glu Asp Arg Gly 
        35                  40                  45              

Val Arg Ala Val Ile Val Arg Gly Glu Gly Lys Gly Phe Cys Ala Gly 
    50                  55                  60                  

Ala Asp Leu Lys Glu Arg Arg Gly Leu Ala Pro His Glu Val Arg Arg 
65                  70                  75                  80  

Asn Val Arg Leu Thr Arg Glu Ala Phe Asp Arg Val Ala Arg Leu Pro 
                85                  90                  95      

Gln Pro Thr Ile Ala Val Leu His Gly Phe Ala Phe Gly Gly Gly Leu 
            100                 105                 110         

Glu Leu Ala Leu Ala Cys Asp Phe Arg Ile Gly Ser Arg Asp Leu Arg 
        115                 120                 125             

Leu Gly Leu Thr Glu Thr Ser Leu Ala Ile Val Pro Gly Ala Gly Gly 
    130                 135                 140                 

Thr Gln Arg Leu Ala Arg Leu Ile Gly Pro Thr Trp Ala Lys Trp Met 
145                 150                 155                 160 

Ile Phe Thr Ala Ala Arg Ile Asp Ala Glu Arg Ala Arg Glu Leu Gly 
                165                 170                 175     

Ile Leu Leu Glu Val Ala Asp Thr Arg Glu Ala Ala Met Asp Ala Ala 
            180                 185                 190         

Arg Ala Leu Ala Arg Ala Ile Ala Glu Asn Gly Pro Val Ala Val Arg 
        195                 200                 205             

Gln Ala Lys Trp Ala Ile Asp Arg Gly Leu Asp Val Asp Leu Ser Thr 
    210                 215                 220                 

Gly Leu Ala Ile Glu Asp Ala Ala Tyr Glu Gly Val Leu Pro Thr Ser 
225                 230                 235                 240 

Asp Arg Leu Glu Ala Leu Ala Ala Phe Ala Glu Lys Arg Lys Pro His 
                245                 250                 255     

Phe Arg Gly Glu 
            260 

<210>   455
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   455
gtggaacagc cgattgtgtg gcagaaggcg gaggacggga tcgcggagct cctcctgaat       60

cggccggatg cgatgaacgc gctcaattac gcgctgctcc gcgcgctgga agatgccgtg      120

cgcgagatcg cggaggaccg cggcgtgcgt gccgtgatcg tgcgcgggga gggaaaggga      180

ttctgcgcgg gagcggattt gaaggaacgg cgcggcctgg cgcctcacga agtgcggcgc      240

aacgtgcgct tgacgcgcga ggcgttcgat cgcgtcgcgc gcctgccgca gccgaccatc      300

gcggtcctgc atggattcgc gttcggaggc gggctggagc tggcgctggc gtgcgacttt      360

cgcatcggca gtcgcgatct tcggctcggt ctgacggaga cgtcgctcgc catcgtccct      420

ggggcgggcg ggacgcagcg gctggcccgc ctcatcgggc cgacgtgggc caagtggatg      480

atcttcacgg ccgcgcgcat cgacgcggag cgcgcgagag agctcggcat cctgctcgag      540

gtggcggata cccgagaggc cgcgatggac gccgcgcgag cgctggcccg cgccatcgcc      600

gaaaacgggc cggtcgcggt gcgccaggcg aagtgggcca tcgatcgcgg cctggacgtc      660

gatctgtcga cggggcttgc catcgaggat gcggcgtatg agggcgttct gccgacctcg      720

gatcggctgg aggcgctcgc ggcgttcgcg gaaaagcgca agccgcactt ccgcggtgat      780

tag                                                                    783


<210>   456
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   456
gtggaacagc cgattgtgtg gcagaaggcg gaggacggga tcgcggagct cctcctgaat       60

cggccggatg cgatgaacgc gctcaattac gcgctgctcc gcgcgctgga agatgccgtg      120

cgcgagatcg cggaggaccg cggcgtgcgt gccgtgatcg tgcgcgggga gggaaaggga      180

ttctgcgcgg gagcggattt gaaggaacgg cgcggcctgg cgcctcacga agtgcggcgc      240

aacgtgcgct tgacgcgcga ggcgttcgat cgcgtcgcgc gcctgccgca gccgaccatc      300

gcggtcctgc atggattcgc gttcggaggc gggctggagc tggcgctggc gtgcgacttt      360

cgcatcggca gtcgcgatct tcggctcggt ctgacggaga cgtcgattgc catcgtccct      420

ggggcgggcg ggacgcagcg gctggcccgc ctcatcgggc cgacgtgggc caagtggatg      480

atcttcacgg ccgcgcgcat cgacgcggag cgcgcgagag agctcggcat cctgctcgag      540

gtggcggata cccgagaggc cgcgatggac gccgcgcgag cgctggcccg cgccatcgcc      600

gaaaacgggc cggtcgcggt gcgccaggcg aagtgggcca tcgatcgcgg cctggacgtc      660

gatctgtcga cggggcttgc catcgaggat gcggcgtatg agggcgttct gccgacctcg      720

gatcggctgg aggcgctcgc ggcgttcgcg gaaaagcgca agccgcactt ccgcggtgaa      780

tag                                                                    783


<210>   457
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   457
gtggaacagc cgattgtgtg gcagaaggcg gaggacggga tcgcggagct cctcctgaat       60

cggccggatg cgatgaacgc gctcaattac gcgctgctcc gcgcgctgga agatgccgtg      120

cgcgagatcg cggaggaccg cggcgtgcgt gccgtgatcg tgcgcgggga gggaaaggga      180

ttctgcgcgg gagcggattt gaaggaacgg cgcggcctgg cgcctcacga agtgcggcgc      240

aacgtgcgct tgacgcgcga ggcgttcgat cgcgtcgcgc gcctgccgca gccgaccatc      300

gcggtcctgc atggattcgc gttcggaggc gggctggagc tggcgctggc gtgcgacttt      360

cgcatcggca gtcgcgaact tcggctcggt ctgacggaga cgtcgctcgc catcgtccct      420

ggggcgggcg ggacgcagcg gctggcccgc ctcatcgggc cgacgtgggc caagtggatg      480

atcttcacgg ccgcgcgcat cgacgcggag cgcgcgagag agctcggcat cctgctcgag      540

gtggcggata cccgagaggc cgcgatggac gccgcgcgag cgctggcccg cgccatcgcc      600

gaaaacgggc cggtcgcggt gcgccaggcg aagtgggcca tcgatcgcgg cctggacgtc      660

gatctgtcga cggggcttgc catcgaggat gcggcgtatg agggcgttct gccgacctcg      720

gatcggctgg aggcgctcgc ggcgttcgcg gaaaagcgca agccgcactt ccgcggtgaa      780

tag                                                                    783


<210>   458
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   458
gtggaacagc cgattgtgtg gcagaaggcg gaggacggga tcgcggagct cctcctgaat       60

cggccggatg cgatgaacgc gctcaattac gcgctgctcc gcgcgctgga agatgccgtg      120

cgcgagatcg cggaggaccg cggcgtgcgt gccgtgatcg tgcgcgggga gggaaaggga      180

ttctgcgcgg gagcggattt gaaggaacgg cgcggcctgg cgcctcacga agtgcggcgc      240

aacgtgcgct tgacgcgcga tgcgttcgat cgcgtcgcgc gcctgccgca gccgaccatc      300

gcggtcctgc atggattcgc gttcggaggc gggctggagc tggcgctggc gtgcgacttt      360

cgcatcggca gtcgcgatct tcggctcggt ctgacggaga cgtcgctcgc catcgtccct      420

ggggcgggcg ggacgcagcg gctggcccgc ctcatcgggc cgacgtgggc caagtggatg      480

atcttcacgg ccgcgcgcat cgacgcggag cgcgcgagag agctcggcat cctgctcgag      540

gtggcggata cccgagaggc cgcgatggac gccgcgcgag cgctggcccg cgccatcgcc      600

gaaaacgggc cggtcgcggt gcgccaggcg aagtgggcca tcgatcgcgg cctggacgtc      660

gatctgtcga cggggcttgc catcgaggat gcggcgtatg agggcgttct gccgacctcg      720

gatcggctgg aggcgctcgc ggcgttcgcg gaaaagcgca agccgcactt ccgcggtgaa      780

tag                                                                    783


<210>   459
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   459
gtggaacagc cgttagtgtg gcagaaggcg gaggacggga tcgcggagct cctcctgaat       60

cggccggatg cgatgaacgc gctcaattac gcgctgctcc gcgcgctgga agatgccgtg      120

cgcgagatcg cggaggaccg cggcgtgcgt gccgtgatcg tgcgcgggga gggaaaggga      180

ttctgcgcgg gagcggattt gaaggaacgg cgcggcctgg cgcctcacga agtgcggcgc      240

aacgtgcgct tgacgcgcga ggcgttcgat cgcgtcgcgc gcctgccgca gccgaccatc      300

gcggtcctgc atggattcgc gttcggaggc gggctggagc tggcgctggc gtgcgacttt      360

cgcatcggca gtcgcgatct tcggctcggt ctgacggaga cgtcgctcgc catcgtccct      420

ggggcgggcg ggacgcagcg gctggcccgc ctcatcgggc cgacgtgggc caagtggatg      480

atcttcacgg ccgcgcgcat cgacgcggag cgcgcgagag agctcggcat cctgctcgag      540

gtggcggata cccgagaggc cgcgatggac gccgcgcgag cgctggcccg cgccatcgcc      600

gaaaacgggc cggtcgcggt gcgccaggcg aagtgggcca tcgatcgcgg cctggacgtc      660

gatctgtcga cggggcttgc catcgaggat gcggcgtatg agggcgttct gccgacctcg      720

gatcggctgg aggcgctcgc ggcgttcgcg gaaaagcgca agccgcactt ccgcggtgaa      780

tag                                                                    783


<210>   460
<211>   986
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   460
Met Ser Val Asp Leu Lys Arg Thr Phe Thr Leu Asp Gly Ser Pro Leu 
                5                   10                  15      

Thr Ala Thr Glu Gly Glu Thr Ile Leu Gln Ala Met Leu Ala Ala Gly 
            20                  25                  30          

Leu Asp Phe Pro His Ile Cys Tyr His Pro Ala Leu Gly Pro Ile Glu 
        35                  40                  45              

Thr Cys Asp Thr Cys Met Val Glu Val Asn Gly Asp Leu Val Arg Ala 
    50                  55                  60                  

Cys Ala Thr Pro Val Val Glu Gly Met Ser Val Arg Thr Lys Ser Val 
65                  70                  75                  80  

Ala Ala Arg Tyr Ala Arg Lys Glu Ala Met Asp Arg Ile Leu Lys Asn 
                85                  90                  95      

His Asp Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Val 
            100                 105                 110         

Val His Asn Thr Thr Met Ala Met Asp Ile Asp His Gln Ser Tyr Pro 
        115                 120                 125             

Phe Arg Glu Lys Pro Tyr Glu Val Asp Met Ser His Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Ser Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Ser Glu Val Leu Ser Ile Asp Trp Asp Arg Glu 
                165                 170                 175     

Ile Pro Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Lys Ala Gly Phe Leu Thr Gly Ile Glu 
    210                 215                 220                 

Pro Glu Pro Leu Gln Arg Met Ile Asp Val Thr Lys Ala Val Glu Pro 
225                 230                 235                 240 

Gly Tyr Arg Ala Ile Phe Ala Ile Ser Glu Ile Glu Ser His Met Arg 
                245                 250                 255     

Asn Ser Arg Ile Lys Arg Thr Lys Thr Val Cys Thr Tyr Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Asp Ile Trp Thr Lys Asp Arg Asp Ile Leu Lys Val 
        275                 280                 285             

Glu Pro Gln Met Glu Ala Pro Thr Asn Gln Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Pro Asp Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Lys Gly Asp Ala Phe His Glu Val Ser Trp Asp Glu 
                325                 330                 335     

Ala Leu Asp Phe Val Ala Lys Arg Leu Thr Glu Ile Arg Gln Gln Tyr 
            340                 345                 350         

Gly Asp Asp Ala Ile Ala Leu Ile Ser Ser Ser Lys Cys Thr Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Ala Val Leu His Thr Asn 
    370                 375                 380                 

Asn Ile Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Glu Gly 
385                 390                 395                 400 

Leu Arg Arg Thr Met Gly Tyr Gly Gly Asp Thr Gly Ser Leu His Asp 
                405                 410                 415     

Leu Ala Met Ala Asp Leu Leu Ile Ile Ile Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Ser His Pro Val Phe Ser Thr Arg Met Arg Arg Ala Lys Lys Lys Tyr 
        435                 440                 445             

Gly Gln Lys His Ile Val Ile Asp Leu Arg Glu His Asp Met Ala His 
    450                 455                 460                 

Arg Ala Asp Leu Phe Val Arg Pro Asn Pro Gly Thr Asp Leu Val Leu 
465                 470                 475                 480 

Ile Ser Ala Val Thr Arg Tyr Ile Ile Asp Gln Gly Trp His Asp Ala 
                485                 490                 495     

Asp Phe Val Arg Asp Arg Val Asp Gly Phe Glu Asp Phe Val Arg Ser 
            500                 505                 510         

Leu Glu Pro Tyr Thr Leu Glu Tyr Ala Glu Arg Val Thr Gly Val Pro 
        515                 520                 525             

Arg Asp Thr Val Ile Gln Ile Ala Thr Met Ile His Glu Ala Lys Ser 
    530                 535                 540                 

Thr Cys Ile Cys Trp Ala Met Gly Val Thr Gln His Lys Gly Gly Ser 
545                 550                 555                 560 

Glu Thr Ser Thr Ala Ile Cys Asn Leu Leu Leu Val Thr Gly Asn Val 
                565                 570                 575     

Gly Arg Pro Gly Thr Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Gly Asp Met Gly Cys Ser Pro Val Tyr Met Pro Gly Tyr 
        595                 600                 605             

Glu Arg Val Asp Asp Pro Ala Val Arg Ala Lys Tyr Glu Thr Ala Trp 
    610                 615                 620                 

Val Val Glu Leu Pro Thr Ser Lys Gly Leu Asp Asn His Glu Met Val 
625                 630                 635                 640 

Asp Ala Ile His Glu Gly Lys Leu Arg Ala Leu Ile Ile Gln Gly Glu 
                645                 650                 655     

Glu Met Ala Leu Val Asp Ser Asn Ser His Tyr Val Arg Glu Ala Phe 
            660                 665                 670         

Ala Lys Leu Asp Leu Leu Val Val Ile Asp Val Phe Phe Ser Lys Thr 
        675                 680                 685             

Ala Glu Tyr Ala Asp Val Val Leu Ala Ala Ser Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln 
705                 710                 715                 720 

Val Phe Glu Pro Leu Gly Glu Ser Arg Pro Asp Trp Val Ile Leu Arg 
                725                 730                 735     

Asp Leu Ala Asn Arg Leu Gly Ala Asn Trp Thr Tyr Ala His Pro Ser 
            740                 745                 750         

Glu Ile Leu Glu Glu Met Ala Ser Leu Ala Ala Leu Met Gln Gly Val 
        755                 760                 765             

Arg Trp Asp Arg Leu Glu Gly Tyr Arg Ser Leu Gln Trp Pro Val His 
    770                 775                 780                 

Pro Asp Gly Thr Asp Thr Pro Leu Leu Tyr Thr Asn Gly Phe Pro Phe 
785                 790                 795                 800 

Pro Asn Gly Lys Ala Arg Leu Val Pro Ala Arg Trp Ile Glu Pro Thr 
                805                 810                 815     

Ala Phe Glu Pro Glu Tyr Asp Leu His Leu Asn Asn Gly Arg Met Leu 
            820                 825                 830         

Glu His Phe His Glu Gly Asn Leu Thr Tyr Arg Val His Gly Leu Lys 
        835                 840                 845             

Glu Lys Val Pro Thr Thr Tyr Leu Glu Val Ser Pro Glu Leu Ala Lys 
    850                 855                 860                 

Glu Arg Gly Ile Glu Thr Gly Ala Leu Val Arg Leu Ile Ser Pro Tyr 
865                 870                 875                 880 

Gly Glu Leu Lys Leu Pro Val Val Val Thr Asp Arg Val Lys Gly Lys 
                885                 890                 895     

Gln Met Tyr Leu Pro Met Asn Thr Ser Asn Asp Glu Glu Ala Ile Asn 
            900                 905                 910         

Ile Leu Thr Ser Ser Glu Ser Asp Glu Thr Thr His Thr Pro Ala Tyr 
        915                 920                 925             

Lys Glu Leu Gln Val Arg Met Glu Val Ile Arg Pro Arg Gly Glu Ser 
    930                 935                 940                 

Pro Met Thr Arg Phe Asn Phe Arg Met His Arg Pro Asn Pro Gln Ser 
945                 950                 955                 960 

Gly Val Arg Val Glu Arg Lys Trp Ser Arg Arg Gly Tyr Val Pro Val 
                965                 970                 975     

Ala Glu Ala Ala Lys Glu Lys Ala Arg Gly 
            980                 985     

<210>   461
<211>   2961
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   461
atgagcgttg atttgaagcg aaccttcacg ctggacggat cgcccctgac ggcgaccgag       60

ggggagacca tcctgcaggc gatgttggcg gctggcctag actttcccca catctgttat      120

catcctgcgc ttggccccat cgagacctgc gacacgtgca tggtagaggt gaatggcgat      180

ctcgtccggg cgtgcgcgac cccggtcgtc gagggcatgt cggtccgcac caaatccgtg      240

gccgcgcggt acgcgcgcaa ggaggcgatg gatcgcatcc tgaaaaacca cgacctctac      300

tgcacggtct gcgacaacaa caacggcaac tgcgtggtgc acaacaccac gatggcgatg      360

gacatcgacc atcagtcgta cccgttccgc gagaagccgt acgaagtcga catgtcgcac      420

ccgttctacc ggtacgatcc gagccagtgc atcctctgcg ggcgatgcgt cgaggcgtgt      480

cagaacctgc aggtcagtga agtgctttcc atcgactggg atcgcgagat tccgcgcgtc      540

atctgggaca atgacgtccc catcaacgag tcgtcgtgcg tctcgtgcgg ccactgcgtg      600

accgtctgcc cctgcaatgc gctcatggag aagtcgatgc tcggcaaggc tggattcctc      660

acgggcatcg aaccggagcc gctgcagcgg atgatcgacg tgacgaaggc ggtggagccc      720

ggctaccgcg ccatctttgc catctccgag atcgagagcc acatgcggaa ttcccgcatc      780

aagcgcacga agaccgtgtg cacgtactgc ggcgtgggct gctcgtttga catctggacg      840

aaggaccggg acatcctgaa ggtcgaaccg cagatggagg cgccgaccaa ccagatctcc      900

acctgcgtca agggaaagtt cggctgggat tttgtgaata gcccggaccg cctcacgaag      960

cccctcatcc gcaagggcga cgcgtttcat gaggtgtcgt gggacgaggc cttggacttc     1020

gtcgcgaagc gcctgacgga aatccgccag caatacggcg acgatgccat cgcattgatc     1080

tcgtcctcga agtgcaccaa cgaggaaaac tacctgatgc aaaaactcgc ccgcgccgtt     1140

ctccacacga acaacatcga caactgttca cggtactgcc agtcgcccgc caccgagggt     1200

ctgcgccgga ccatgggtta cggcggcgac accggctcgc tccacgatct cgccatggcc     1260

gatctgctca tcatcattgg cgcgaacccg gccgagtccc accccgtctt ctcgacccgc     1320

atgcggcggg ccaagaagaa gtacggccag aagcacatcg tgatcgacct tcgcgaacac     1380

gatatggcgc accgcgccga cctgttcgtc cggccgaatc ctggaaccga tctggtgctc     1440

atctcggccg tgacgaggta catcatcgac cagggttggc acgacgccga cttcgtgcgc     1500

gatcgcgtcg acggttttga agatttcgtc cgctcgctcg agccgtatac gctcgagtac     1560

gccgagcgcg tgacgggcgt gccgcgcgac accgtgattc agatcgccac gatgatccat     1620

gaggccaagt ccacctgcat ctgttgggcg atgggcgtga cgcagcacaa ggggggcagc     1680

gagaccagca ccgccatctg caacctcctg ctcgtcacgg ggaacgtcgg gcgcccaggc     1740

accggggcct atccgctccg aggccacaac aacgtccaag gggcgggcga catgggctgc     1800

agcccggtgt acatgccggg ctacgagcgc gtcgatgatc cggccgtgcg agccaagtac     1860

gagacggcct gggtcgtgga gctgccgacg agcaaggggc tcgacaacca cgagatggtg     1920

gacgcgattc acgagggcaa acttcgggcc cttatcattc agggcgagga gatggcgctc     1980

gtcgactcga attcgcacta cgtccgcgag gcgtttgcga agctggatct gctcgtcgtg     2040

atcgacgtgt tcttcagcaa gactgctgag tacgccgacg tggtgctcgc cgcgagcccg     2100

agcctggaga aggagggcac gttcacgaac acggaacggc gcatccagcg cctgtaccag     2160

gtgttcgaac cgctcggcga atctcgcccg gactgggtca ttctgcgcga tctcgccaat     2220

cgcctgggcg ccaactggac gtacgcgcac ccgtccgaaa tcctcgagga aatggcgagc     2280

ttggcggcgc tgatgcaggg ggttcgctgg gatcgactgg agggctatcg cagcctgcag     2340

tggccggttc atcccgacgg gaccgatacg ccgctgctct acacgaacgg tttcccgttc     2400

ccgaatggga aggcgcggct cgttcccgcc aggtggatcg aaccgaccgc gtttgaaccg     2460

gagtatgatc tccatctcaa caacggccgc atgctcgagc acttccacga ggggaatcta     2520

acctatcgcg tccacggcct caaggaaaag gtgccgacga cgtacctcga ggtgtcgcca     2580

gaactcgcca aggagcgggg catcgagacg ggggcgttgg ttcgcctcat ctcgccgtac     2640

ggcgagttga agcttcccgt cgtggtgacg gatcgagtca agggcaagca aatgtatttg     2700

ccgatgaaca cgtccaacga tgaagaggcc atcaacatcc tcacgtcgag cgagtcggac     2760

gagacgacgc acacgccggc gtacaaggag ctgcaggtgc ggatggaagt gattcggccg     2820

cgtggggaaa gcccgatgac acggttcaac ttccggatgc acaggccgaa tccgcaatcc     2880

ggcgtgcgcg tcgaacggaa gtggtcgcgg cgcggttacg tgccggtggc cgaggcggcg     2940

aaggaaaagg cgagggggtg a                                               2961


<210>   462
<211>   971
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   462
Thr Ile Asn Gly Val Glu Met Glu Ala Pro Asp Gly Gln Thr Val Leu 
                5                   10                  15      

Gln Leu Leu Asn Asn Ser Ser Ile Asp Val Pro His Val Cys Tyr His 
            20                  25                  30          

Pro Ser Leu Gly Pro Ile Glu Thr Cys Asp Thr Cys Ile Val Asn Val 
        35                  40                  45              

Asn Gly Glu Leu Val Arg Ser Cys Ser Ala Gln Ile Lys Asp Gly Asp 
    50                  55                  60                  

Val Ile Asp Thr Leu Ser Ser Asp Val Lys Lys Ala Gln Ile Ile Gly 
65                  70                  75                  80  

Met Asp Asn Ile Leu His Asn His Glu Leu Tyr Cys Thr Val Cys Asp 
                85                  90                  95      

Tyr Asn Asn Gly Ser Cys Glu Val His Asn Thr Val Lys Glu Met Lys 
            100                 105                 110         

Ile Asn His Gln Ser Ile Pro Phe Asp Gln Lys Pro Tyr Pro Lys Asp 
        115                 120                 125             

Glu Ser Asn Pro Phe Tyr Arg Tyr Asp Pro Asp Gln Cys Ile Leu Cys 
    130                 135                 140                 

Gly Arg Cys Val Glu Ala Cys Gln Asp Val Gln Val Thr Glu Thr Leu 
145                 150                 155                 160 

Ser Ile Asp Trp Glu Arg Lys Arg Pro Arg Val Ile Trp Asp Gln Asp 
                165                 170                 175     

Val Pro Ile Asn Glu Ser Ser Cys Val Ser Cys Gly His Cys Ser Thr 
            180                 185                 190         

Val Cys Pro Cys Asn Ala Met Met Glu Lys Gly Met Glu Gly Glu Ala 
        195                 200                 205             

Gly Tyr Leu Thr Gly Ile Asn Gln Glu Thr Leu Arg Pro Met Ile Asp 
    210                 215                 220                 

Ile Thr Lys Gly Val Glu Thr Gly Tyr Gly Ser Ile Leu Ala Ile Ser 
225                 230                 235                 240 

Asp Met Glu Ser Ala Met Arg Asp Glu Arg Ile Lys Lys Thr Lys Thr 
                245                 250                 255     

Val Cys Thr Tyr Cys Gly Val Gly Cys Ser Phe Asp Ile Trp Thr Lys 
            260                 265                 270         

Gly Arg Asp Ile Leu Lys Val Glu Pro Gln Ala Glu Ala Pro Ala Asn 
        275                 280                 285             

Gly Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp Asp Phe Val Asn 
    290                 295                 300                 

Ser Glu Lys Arg Leu Thr Lys Pro Leu Ile Arg Glu Gly Asp Ser Phe 
305                 310                 315                 320 

Arg Glu Ala Glu Trp Asp Glu Ala Leu Gln Leu Ile Ala Asp Lys Phe 
                325                 330                 335     

Thr Asp Ile Lys Glu His Phe Gly Pro Asp Ala Leu Ala Phe Ile Thr 
            340                 345                 350         

Ser Ser Lys Cys Thr Asn Glu Glu Ser Tyr Val Met Gln Lys Leu Ala 
        355                 360                 365             

Arg Ala Val Ile Gly Thr Asn Asn Val Asp Asn Cys Ser Arg Tyr Cys 
    370                 375                 380                 

Gln Ser Pro Ala Thr Ala Gly Leu Phe Arg Thr Val Gly Tyr Gly Gly 
385                 390                 395                 400 

Asp Ser Gly Ser Ile Thr Asp Ile Glu Lys Ala Glu Leu Val Leu Ile 
                405                 410                 415     

Ile Gly Ser Asn Thr Ser Glu Ser His Pro Val Leu Ser Thr Arg Ile 
            420                 425                 430         

Lys Arg Ser His Lys Leu His Gly Gln Lys Leu Val Val Ala Asp Leu 
        435                 440                 445             

Arg Lys His Glu Met Ala Glu Arg Ser Asp Val Phe Phe Gln Pro Arg 
    450                 455                 460                 

Ala Gly Ser Asp Ile Val Trp Leu Asn Ala Val Ser Lys Tyr Leu Leu 
465                 470                 475                 480 

Asp His Asp Leu Ala Asp Thr Ser Phe Leu Lys Glu Arg Val Asn Gly 
                485                 490                 495     

Leu Asp Glu Phe Val Lys Ser Leu Glu Pro Tyr Thr Met Glu Tyr Ala 
            500                 505                 510         

Glu Lys His Thr Gly Val Asp Lys Asp Thr Leu Ile Lys Val Ala Arg 
        515                 520                 525             

Met Ile His Glu Ala Gly Ser Val Cys Ala Leu Trp Ala Met Gly Val 
    530                 535                 540                 

Thr Gln His Ile Gly Gly Ser Asp Thr Ser Thr Ala Ile Ser Asn Met 
545                 550                 555                 560 

Leu Leu Val Thr Gly Asn Tyr Gly Lys Pro Gly Ala Gly Ser Tyr Pro 
                565                 570                 575     

Leu Arg Gly His Asn Asn Val Gln Gly Ala Ser Asp Phe Gly Ser Met 
            580                 585                 590         

Pro Asp Ser Phe Pro Gly Tyr Glu Lys Val Thr Asp Glu Lys Ala Arg 
        595                 600                 605             

Lys Lys Tyr Glu Gln Gly Trp Gly Thr Asp Leu Pro Lys Glu Ile Gly 
    610                 615                 620                 

Met Thr Asn His Glu Met Ile Glu Gly Ile His Ser Gly Lys Leu Lys 
625                 630                 635                 640 

Ser Met Tyr Leu Lys Gly Glu Glu Met Gly Leu Val Asp Ser Asn Ile 
                645                 650                 655     

Asn His Val His Ala Ala Phe Glu Lys Leu Asp Phe Phe Val Val Gln 
            660                 665                 670         

Asp Ile Phe Leu Ser Arg Thr Ala Glu Phe Ala Asp Val Val Leu Pro 
        675                 680                 685             

Ala Ser Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr Asn Thr Glu Arg 
    690                 695                 700                 

Arg Val Gln Arg Leu Tyr Glu Val Phe Glu Pro Leu Gly Asp Ser Lys 
705                 710                 715                 720 

Pro Asp Trp Gln Ile Ile Thr Asp Ile Ala Asn Arg Leu Gly Ala Asp 
                725                 730                 735     

Trp His Tyr Glu His Pro Ala Asp Ile Met Glu Glu Ala Ala Met Leu 
            740                 745                 750         

Ser Pro Leu Tyr Ala Gly Val Thr Tyr Glu Arg Leu Glu Gly Tyr Asn 
        755                 760                 765             

Ser Leu Gln Trp Pro Val Ala Ala Asp Gly Thr Asp Ser Pro Leu Leu 
    770                 775                 780                 

Phe Thr Asp Lys Phe Pro Phe Ser Asp Gly Lys Ala Ile Leu Tyr Pro 
785                 790                 795                 800 

Val Gln Trp Thr Glu Pro Lys Glu Phe Asp Glu Glu Tyr Asp Ile His 
                805                 810                 815     

Val Asn Asn Gly Arg Leu Leu Glu His Phe His Glu Gly Asn Leu Thr 
            820                 825                 830         

Tyr Arg Ser Lys Gly Ile Ser Glu Lys Thr Pro Ser Val Phe Leu Glu 
        835                 840                 845             

Val Ser Pro Glu Leu Ala Glu Glu Arg Gly Leu Glu Asp Gly Thr Leu 
    850                 855                 860                 

Val Arg Leu Thr Ser Pro Tyr Gly Asn Val Lys Val Lys Cys Val Ile 
865                 870                 875                 880 

Thr Asp Arg Val Lys Gly Lys Gln Val Tyr Leu Pro Met Asn Asp Ser 
                885                 890                 895     

Lys Asp Ala Ala Ile Asn Leu Leu Thr Ser Ser Tyr Ala Asp Lys Asp 
            900                 905                 910         

Thr Asp Thr Pro Ala Tyr Lys Glu Thr Ser Ala Lys Met Glu Ile Leu 
        915                 920                 925             

Lys Lys Glu Gly Val Asn Pro Leu Pro Lys Ile Asn Phe Arg Tyr Gly 
    930                 935                 940                 

Asn Pro Gln Pro Gln Ile Gly Val Arg Val Asp Arg Lys Trp Ala Arg 
945                 950                 955                 960 

Lys Asp Tyr Val Phe Pro Gly Asp Ala Val Lys 
                965                 970     

<210>   463
<211>   966
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   463
Ile Asn Gly Gln Glu Leu Ala Ala Arg Lys Gly Gln Thr Ile Leu Glu 
                5                   10                  15      

Val Ala Asn Ala His Asp Met Tyr Ile Pro Ala Ile Cys Tyr His Pro 
            20                  25                  30          

Asn Leu Gly Ser Ile Gln Thr Cys Asp Thr Cys Phe Val Asn Val Asn 
        35                  40                  45              

Gly Asn Leu Val Arg Ala Cys Ala Thr Lys Val Glu Pro Gly Met Glu 
    50                  55                  60                  

Val Glu Ser Gly Ser Lys Pro Val Lys Asp Ala Gln Tyr Glu Ala Met 
65                  70                  75                  80  

Ser Arg Ile Leu Lys Asn His Glu Leu Tyr Cys Thr Val Cys Asp Asn 
                85                  90                  95      

Asn Asn Gly Asn Cys Val Val His Asn Thr Ala Glu His Leu Glu Ile 
            100                 105                 110         

Glu His Gln Lys Tyr Gln Phe Glu Ala Lys Pro Tyr Pro Pro Asp Gln 
        115                 120                 125             

Ser His Pro Phe Tyr Arg Tyr Glu Pro Asp Gln Cys Ile Leu Cys Gly 
    130                 135                 140                 

Arg Cys Val Glu Ala Cys Gln Asp Leu Gln Val Asn Glu Thr Leu Thr 
145                 150                 155                 160 

Ile Asp Trp Asp Arg Glu Val Pro Arg Val Ile Trp Asp Asn Asp Val 
                165                 170                 175     

Pro Ile Asp Glu Ser Ser Cys Val Ser Cys Gly His Cys Val Thr Val 
            180                 185                 190         

Cys Pro Cys Asn Ala Leu Met Glu Lys Ser Met Leu Gly Glu Ala Gly 
        195                 200                 205             

Tyr Leu Thr Gly Ile Pro Gln Lys Val Leu Glu Pro Met Ile Asp Leu 
    210                 215                 220                 

Thr Lys Glu Val Glu Pro Gly Tyr Lys Glu Ile Phe Ala Ile Ser Glu 
225                 230                 235                 240 

Met Glu Ala Ala Met Arg Lys Ser Arg Ile Lys Arg Thr Lys Thr Val 
                245                 250                 255     

Cys Thr Tyr Cys Gly Val Gly Cys Ser Phe Glu Ile Trp Thr Lys Gly 
            260                 265                 270         

Arg His Ile Leu Lys Val Glu Pro Gln Glu His Ala Pro Val Asn Gly 
        275                 280                 285             

Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp Asp Phe Val Asn Ser 
    290                 295                 300                 

Glu Glu Arg Leu Thr Lys Pro Leu Ile Arg Lys Gly Glu Glu Phe Val 
305                 310                 315                 320 

Glu Ala Ser Trp Asp Glu Ala Leu Asn Leu Ile Ala Ser Lys Leu Gln 
                325                 330                 335     

Glu Ile Lys Lys Gln His Gly Pro Asp Ala Leu Gly Phe Ile Ala Ser 
            340                 345                 350         

Ser Lys Cys Ser Asn Glu Glu Asn Tyr Leu Phe Gln Lys Phe Ala Arg 
        355                 360                 365             

Ala Ile Ile Gly Thr Asn Asn Leu Asp Asn Cys Ser Arg Tyr Cys Gln 
    370                 375                 380                 

Ser Pro Ala Thr Ser Gly Leu Leu Arg Thr Val Gly Ile Gly Gly Asp 
385                 390                 395                 400 

Ser Gly Thr Ile Arg Asp Ile Gln Gln Ala Asp Leu Val Val Thr Val 
                405                 410                 415     

Gly Ala Asn Pro Ala Glu Ser His Pro Val Leu Ala Thr Arg Ile Lys 
            420                 425                 430         

Arg Ala His Lys Leu His Gly Gln Lys Leu Met Val Val Asp Leu Arg 
        435                 440                 445             

Glu Asn Glu Leu Ala Ser Arg Ala Asn Leu Phe Ile His Ser Lys Pro 
    450                 455                 460                 

Ser Thr Asp Leu Ile Trp Leu Asn Ala Val Thr Lys Tyr Ile Leu Asp 
465                 470                 475                 480 

Gln Gly Trp Glu Asp Lys Ala Phe Leu Glu Ala Arg Val Lys Gly Leu 
                485                 490                 495     

Asp Lys Phe Arg Ala Ser Leu Glu Lys Tyr Thr Leu Ala Phe Ala Glu 
            500                 505                 510         

Glu Lys Thr Gly Ile Ser Lys Glu Asn Leu Ile Lys Met Ala Thr Met 
        515                 520                 525             

Ile His Glu Ala Lys Ser Val Cys Ile Leu Trp Ala Met Gly Ile Thr 
    530                 535                 540                 

Gln His Thr Cys Gly Thr Asp Ala Ser Thr Ala Ile Ser Asn Leu Leu 
545                 550                 555                 560 

Leu Val Thr Gly Asn Tyr Gly Arg Pro Gly Thr Gly Ala Tyr Pro Leu 
                565                 570                 575     

Arg Gly His Asn Asn Val Gln Gly Ala Cys Asp Phe Gly Thr Met Pro 
            580                 585                 590         

Ala Trp Phe Pro Gly Tyr Glu Pro Val Glu Asp Asn Glu Val Arg Glu 
        595                 600                 605             

Arg Tyr Glu Lys Ala Trp Gly Val Lys Leu Pro Glu Asn Pro Gly Leu 
    610                 615                 620                 

Asp Asn His Gln Met Ile Gly Gly Ile Lys Ser Gly Lys Leu Arg Gly 
625                 630                 635                 640 

Leu Tyr Leu Phe Gly Glu Glu Met Ala Ile Val Asp Ser Asn Ile Asn 
                645                 650                 655     

Phe Val Glu Glu His Leu Glu Lys Leu Asp Phe Phe Val Val Gln Asp 
            660                 665                 670         

Val Phe Phe Ser Lys Thr Ala Gln Phe Ala Asp Val Ile Leu Pro Ala 
        675                 680                 685             

Ala Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg 
    690                 695                 700                 

Ile Gln Arg Phe Tyr Gln Val Phe Glu Pro Met Gly Glu Ser Lys Pro 
705                 710                 715                 720 

Asp Trp Val Ile Phe Gln Glu Leu Ala Asn Lys Met Gly Ala Gln Trp 
                725                 730                 735     

His Tyr Gln His Pro Gly Glu Ile Met Ala Glu Ala Ala Ser Leu Ala 
            740                 745                 750         

Lys Tyr Phe Ala Gly Ile Ser Tyr Glu Arg Leu Glu Gly Phe Asn Ser 
        755                 760                 765             

Gln Ile Trp Pro Val Lys Lys Asp Gly Thr Ser Thr Pro Leu Leu Tyr 
    770                 775                 780                 

Gln Asp Arg Phe Ala Phe Pro Asp Gly Lys Ala Arg Leu Val Pro Val 
785                 790                 795                 800 

Asp Trp Glu Pro Pro Phe Ser Ala Gly Glu Gly Phe Asp Tyr His Leu 
                805                 810                 815     

Asn Asn Gly Arg Leu Leu Glu Gln Phe His Glu Gly Asn Leu Thr Asp 
            820                 825                 830         

Arg Ser Pro Gly Ile His His Lys Val Pro Glu Pro Trp Leu Glu Ile 
        835                 840                 845             

Ser Pro Glu Ala Ala Ser Glu Arg Gly Ile Lys Asp Gly Ala Leu Val 
    850                 855                 860                 

Arg Leu Thr Ser Pro Tyr Gly Lys Val Lys Val Arg Ala Val Val Thr 
865                 870                 875                 880 

Gly Arg Val Gln Gly Lys Glu Leu Tyr Leu Thr Met Asn Ala Arg Lys 
                885                 890                 895     

Glu Asp Glu Met Val Asn Arg Leu Thr Ser Ser Tyr His Asp Arg Val 
            900                 905                 910         

Thr His Thr Pro Asn Tyr Lys Glu Met Gly Val Lys Met Glu Ile Leu 
        915                 920                 925             

Glu Glu Lys Gly Lys Pro Pro Leu Pro Lys Val Asn His Arg Tyr Gly 
    930                 935                 940                 

Asn Arg Ile Pro Gln Ile Ser Val Arg Val Glu Glu Lys Trp Lys Arg 
945                 950                 955                 960 

Asp Asp Phe Ile Pro Ile 
                965     

<210>   464
<211>   987
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   464
Asp Leu Pro Asp Thr Tyr Gln Val Lys Leu Asn Gly Ala Glu Val Lys 
                5                   10                  15      

Val Ala Ala Gly Asp Glu Thr Thr Ile Leu Gln Leu Leu Gln Asn Ser 
            20                  25                  30          

Ser Val Glu Val Pro Asn Val Cys Tyr His Pro Ser Leu Gly Pro Ile 
        35                  40                  45              

Glu Thr Cys Asp Thr Cys Ile Val Ser Val Asn Gly Glu Leu Val Arg 
    50                  55                  60                  

Ser Cys Ser Thr Lys Leu Asn Asp Gly Asp Ile Ile Asp Thr Val Ser 
65                  70                  75                  80  

Ala Asp Val Lys Glu Ala Gln Val Ile Gly Met Asp Arg Ile Leu Thr 
                85                  90                  95      

Asn His Glu Leu Tyr Cys Thr Val Cys Asp Tyr Asn Asn Gly Gly Cys 
            100                 105                 110         

Glu Val His Asn Thr Val Lys Glu Met Lys Ile Asn His Gln Ser Val 
        115                 120                 125             

Pro Phe Ala Gln Lys Pro Tyr Pro Ala Asp Asn Ser His Pro Phe Tyr 
    130                 135                 140                 

Arg Tyr Asp Pro Asp Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala 
145                 150                 155                 160 

Cys Gln Asp Val Gln Val Thr Glu Thr Leu Thr Ile Asp Trp Glu Arg 
                165                 170                 175     

Glu Lys Pro Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser 
            180                 185                 190         

Ser Cys Val Ser Cys Gly His Cys Ser Thr Val Cys Pro Cys Asn Ala 
        195                 200                 205             

Met Leu Glu Lys Gly Met Glu Gly Glu Ala Gly Tyr Leu Thr Gly Ile 
    210                 215                 220                 

Ala Lys Gln Thr Leu Arg Pro Met Ile Glu Ile Thr Lys Asn Val Glu 
225                 230                 235                 240 

Thr Gly Tyr Gly Ser Ile Leu Ala Ile Ser Asp Met Glu Ala Ala Met 
                245                 250                 255     

Arg Asp Glu Arg Ile Lys Lys Thr Lys Thr Val Cys Thr Tyr Cys Gly 
            260                 265                 270         

Val Gly Cys Ser Phe Asp Val Trp Thr Lys Gly Arg Glu Ile Leu Lys 
        275                 280                 285             

Val Asp Pro Gln Pro Glu Ala Pro Ala Asn Gly Ile Ser Thr Cys Val 
    290                 295                 300                 

Lys Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Glu Glu Arg Leu Thr 
305                 310                 315                 320 

Lys Pro Leu Ile Arg Glu Gly Glu Phe Phe Arg Glu Ala Glu Trp Asp 
                325                 330                 335     

Glu Ala Ile Ser Leu Ile Ala Arg Arg Phe Thr Glu Ile Lys Asn Glu 
            340                 345                 350         

His Gly Ala Gln Ala Met Ser Phe Ile Ser Ser Ser Lys Cys Thr Asn 
        355                 360                 365             

Glu Glu Ser Phe Leu Met Gln Lys Leu Gly Arg Ala Val Ile Gly Thr 
    370                 375                 380                 

Asn Asn Ile Asp Asn Cys Ser Arg Tyr Cys Gln Thr Pro Ala Thr Val 
385                 390                 395                 400 

Gly Leu Phe Arg Thr Val Gly Tyr Gly Gly Asp Ala Gly Ser Ile Arg 
                405                 410                 415     

Asp Ile Gln Met Ser Asp Leu Val Leu Ile Ile Gly Ser Asn Thr Ala 
            420                 425                 430         

Glu Ser His Pro Val Leu Ser Thr Arg Val Lys Arg Ser His Lys Leu 
        435                 440                 445             

Gly Gly Gln Lys Leu Ile Val Ala Asp Leu Arg Lys His Glu Met Ala 
    450                 455                 460                 

Asp Arg Ala Asp Leu Phe Val Gln Pro Lys Ala Gly Thr Asp Ile Val 
465                 470                 475                 480 

Trp Leu Ser Ala Val Ala Lys Tyr Ile Ile Asp Asn Gly Met Ala Asp 
                485                 490                 495     

Glu Glu Phe Leu Ala Glu Lys Val Asn Gly Leu Asp Glu Phe Thr Lys 
            500                 505                 510         

Asn Leu Glu Lys Tyr Thr Met Glu Tyr Ala Ala Glu Val Thr Gly Ile 
        515                 520                 525             

Ala Leu Glu Gln Leu Ile Asp Met Ala Glu Met Ile Gly Arg Ala Lys 
    530                 535                 540                 

Ser Val Cys Ala Leu Trp Ala Met Gly Ile Thr Gln His Met Gly Gly 
545                 550                 555                 560 

Ser Asp Ala Ser Thr Ala Ile Ser Asn Leu Leu Leu Val Thr Gly Asn 
                565                 570                 575     

Tyr Ala Lys Pro Gly Ala Gly Ala Tyr Pro Leu Arg Gly His Asn Asn 
            580                 585                 590         

Val Gln Gly Ala Ser Asp Phe Gly Ser Met Pro Asn Met Phe Pro Gly 
        595                 600                 605             

Tyr Gln Glu Val Ala Asp Pro Glu Ile Arg Lys Lys Tyr Glu Leu Ala 
    610                 615                 620                 

Trp Gly Thr Glu Leu Pro Gly Glu Pro Gly Leu Asn Asn His Glu Met 
625                 630                 635                 640 

Val Glu Gly Ile His Ala Gly Thr Leu Lys Ala Met Tyr Leu Lys Gly 
                645                 650                 655     

Glu Asp Met Gly Leu Val Asp Ser Asn Ile Asn His Val His Ala Ala 
            660                 665                 670         

Phe Glu Lys Leu Asp Phe Phe Val Val Gln Asp Ile Phe Leu Ser Lys 
        675                 680                 685             

Thr Ala Glu Phe Ala Asp Val Val Leu Pro Ala Ser Pro Ser Leu Glu 
    690                 695                 700                 

Lys Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr 
705                 710                 715                 720 

Gln Ala Leu Glu Pro Leu Gly Asp Ser Lys Pro Asp Trp Gln Ile Ile 
                725                 730                 735     

Met Glu Ile Ala Asn Ser Leu Gly Ala Gly Trp Asn Tyr Thr His Pro 
            740                 745                 750         

Ser Glu Ile Met Glu Glu Ala Ser Arg Leu Met Pro Leu Tyr Ser Gly 
        755                 760                 765             

Val Thr Tyr Glu Arg Leu Glu Gly Tyr Asn Ser Leu Gln Trp Pro Val 
    770                 775                 780                 

Ala Glu Asp Gly Gln Asp Thr Pro Leu Leu Tyr Thr Glu Arg Phe Pro 
785                 790                 795                 800 

Phe Glu Asp Gly Arg Ala Arg Leu Val Pro Val Asp Trp Thr Lys Pro 
                805                 810                 815     

Leu Glu Phe Glu Glu Glu Tyr Asp Leu His Ile Asn Asn Gly Arg Leu 
            820                 825                 830         

Leu Glu His Phe His Glu Gly Asn Met Thr Tyr Arg Ser Lys Gly Ile 
        835                 840                 845             

Ser Glu Lys Thr Pro Ser Val Phe Leu Glu Val Ser Pro Glu Leu Ala 
    850                 855                 860                 

Glu Glu Arg Gly Leu Glu Ser Gly Thr Leu Val Arg Leu Ser Ser Pro 
865                 870                 875                 880 

Tyr Gly Asn Val Lys Val Gln Cys His Ile Thr Asp Arg Val Lys Gly 
                885                 890                 895     

Lys Glu Val Tyr Leu Pro Met Asn Asp Arg Gly Glu Ala Ala Ile Asn 
            900                 905                 910         

Leu Leu Thr Ser Ser Tyr Ala Asp Lys Asp Thr Asp Thr Pro Ala Tyr 
        915                 920                 925             

Lys Glu Ile Arg Ala Lys Met Glu Ile Leu Lys Ala Lys Gly Glu Asp 
    930                 935                 940                 

Pro Leu Pro Arg Ile Asn His Arg Tyr Gly Asn Pro Gln Pro Gln Ile 
945                 950                 955                 960 

Gly Val Gln Val Gln Lys Lys Trp Ala Arg Lys Asp Tyr Ile Phe Pro 
                965                 970                 975     

Gly Asp Leu Val Lys Lys Glu Arg Glu His Gly 
            980                 985         

<210>   465
<211>   975
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   465
Lys Lys Thr Ile Thr Ile Asn Gly Val Glu Met Glu Ala Ser Glu Glu 
                5                   10                  15      

Gln Thr Val Leu Gln Leu Leu Asn Asn Ser Ser Ile Glu Val Pro Gln 
            20                  25                  30          

Val Cys Tyr His Pro Ser Leu Gly Pro Ile Glu Thr Cys Asp Thr Cys 
        35                  40                  45              

Ile Val Ser Ile Asn Gly Glu Leu Lys Arg Ser Cys Ser Ala Glu Leu 
    50                  55                  60                  

Lys Asp Gly Asp Val Ile Asp Thr Leu Ser Pro Asp Val Lys Lys Ala 
65                  70                  75                  80  

Gln Val Ile Gly Met Asp Lys Ile Leu Tyr Asn His Glu Leu Tyr Cys 
                85                  90                  95      

Thr Val Cys Asp Tyr Asn Asn Gly Gly Cys Glu Ile His Asn Thr Val 
            100                 105                 110         

Lys Glu Met Lys Ile Asn His Gln Ser Ile Pro Phe Asp His Lys Pro 
        115                 120                 125             

Tyr His Lys Asp Glu Ser His Pro Phe Tyr Arg Tyr Asp Pro Asp Gln 
    130                 135                 140                 

Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys Gln Asp Val Gln Val 
145                 150                 155                 160 

Thr Glu Thr Leu Thr Ile Asp Trp Glu Arg Lys Arg Pro Arg Val Ile 
                165                 170                 175     

Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser Cys Val Ser Cys Gly 
            180                 185                 190         

His Cys Ser Thr Val Cys Pro Cys Asn Ala Met Met Glu Lys Gly Met 
        195                 200                 205             

Glu Gly Glu Ala Gly Tyr Leu Thr Gly Ile Asn Asn Glu Thr Leu Arg 
    210                 215                 220                 

Pro Met Ile Glu Ile Thr Lys Gly Val Glu Thr Gly Tyr Gly Ser Ile 
225                 230                 235                 240 

Leu Ala Ile Ser Asp Met Glu Ser Ala Met Arg Asp Glu Arg Ile Lys 
                245                 250                 255     

Lys Thr Lys Thr Val Cys Thr Tyr Cys Gly Val Gly Cys Ser Phe Asp 
            260                 265                 270         

Val Trp Thr Lys Gly Arg Asp Ile Leu Lys Val Glu Pro Gln Glu Glu 
        275                 280                 285             

Ala Pro Ala Asn Gly Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp 
    290                 295                 300                 

Asp Phe Val Asn Ser Glu Glu Arg Leu Thr Lys Pro Leu Ile Arg Glu 
305                 310                 315                 320 

Gly Asp His Phe Arg Glu Ala Glu Trp Glu Glu Ala Leu Leu Leu Ile 
                325                 330                 335     

Ala Ser Lys Phe Thr Glu Leu Lys Glu Ala Phe Gly Pro Asp Ser Leu 
            340                 345                 350         

Ala Phe Ile Thr Ser Ser Lys Cys Thr Asn Glu Glu Ser Tyr Leu Met 
        355                 360                 365             

Gln Lys Leu Ala Arg Gly Val Ile Gly Thr Asn Asn Val Asp Asn Cys 
    370                 375                 380                 

Ser Arg Tyr Cys Gln Ser Pro Ala Thr Ala Gly Leu Phe Arg Thr Val 
385                 390                 395                 400 

Gly Tyr Gly Gly Asp Ser Gly Ser Ile Thr Asp Ile Ala Gln Ala Asp 
                405                 410                 415     

Leu Val Leu Ile Ile Gly Ser Asn Thr Ser Glu Ser His Pro Val Leu 
            420                 425                 430         

Ser Thr Arg Ile Lys Arg Ala His Lys Leu Arg Gly Gln Lys Val Ile 
        435                 440                 445             

Val Ala Asp Ile Arg Lys His Glu Met Ala Glu Arg Ser Asp Leu Phe 
    450                 455                 460                 

Val Gln Pro Arg Ala Gly Ser Asp Ile Val Trp Leu Asn Ala Ile Ala 
465                 470                 475                 480 

Lys Tyr Leu Ile Glu Asn Gly Lys Ala Asp Glu Arg Phe Leu Arg Glu 
                485                 490                 495     

Arg Val Asn Gly Arg Asp Glu Tyr Val Lys Ser Leu Ala Pro Tyr Thr 
            500                 505                 510         

Leu Glu Tyr Ala Glu Glu Lys Thr Gly Ile Asp Gln Glu Thr Leu Ile 
        515                 520                 525             

Gln Met Ala Glu Met Ile Gly Gln Ala Asp Ser Val Cys Ala Leu Trp 
    530                 535                 540                 

Ala Met Gly Val Thr Gln His Ile Gly Gly Ser Asp Thr Ser Thr Ala 
545                 550                 555                 560 

Ile Ser Asn Leu Leu Leu Val Thr Gly Asn Tyr Gly Lys Pro Gly Ala 
                565                 570                 575     

Gly Ser Tyr Pro Leu Arg Gly His Asn Asn Val Gln Gly Ala Ser Asp 
            580                 585                 590         

Phe Gly Ser Met Pro Asp Arg Leu Pro Gly Tyr Glu Lys Val Thr Asp 
        595                 600                 605             

Glu Gln Val Arg Gln Lys Tyr Glu Arg Val Trp Gly Val Pro Leu Pro 
    610                 615                 620                 

Lys Glu Pro Gly Met Thr Asn His Glu Met Ile Glu Lys Ile His Ser 
625                 630                 635                 640 

Gly Gln Leu Lys Ala Met Tyr Val Lys Gly Glu Glu Met Gly Leu Val 
                645                 650                 655     

Asp Ser Asn Ile Asn His Val His Ala Ala Tyr Glu Lys Leu Asp Phe 
            660                 665                 670         

Phe Val Val Gln Asp Ile Phe Leu Ser Arg Thr Ala Glu Phe Ala Asp 
        675                 680                 685             

Val Val Leu Pro Ala Ser Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr 
    690                 695                 700                 

Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln Val Phe Glu Pro Leu 
705                 710                 715                 720 

Gly Glu Ser Lys Pro Asp Trp Gln Ile Ile Met Glu Val Ala Asn Lys 
                725                 730                 735     

Leu Gly Ala Gly Trp Leu Tyr Glu His Pro Ala Asp Ile Met Glu Glu 
            740                 745                 750         

Ala Ala Lys Leu Ser Pro Ile Tyr Ala Gly Val Thr Tyr Glu Arg Leu 
        755                 760                 765             

Glu Gly Tyr Asn Ser Leu Gln Trp Pro Val Asn Ala Asp Gly Lys Asp 
    770                 775                 780                 

Ser Pro Leu Leu Phe Thr Glu Arg Phe Pro Phe Pro Asp Gly Lys Ala 
785                 790                 795                 800 

Ile Leu Tyr Pro Val Gln Trp Thr Glu Pro Lys Glu Phe Gly Glu Glu 
                805                 810                 815     

Tyr Asp Ile His Val Asn Asn Gly Arg Leu Leu Glu His Phe His Glu 
            820                 825                 830         

Gly Asn Leu Thr Tyr Lys Ser Lys Gly Ile Ser Glu Lys Thr Pro Glu 
        835                 840                 845             

Val Phe Leu Glu Ile Ser Pro Glu Leu Ala Ala Glu Arg Gly Ile Gln 
    850                 855                 860                 

Asp Gly Thr Leu Val Arg Leu Thr Ser Pro Phe Gly Asn Val Lys Val 
865                 870                 875                 880 

Lys Cys Leu Ile Thr Asp Arg Val Lys Gly Lys Glu Val Tyr Leu Pro 
                885                 890                 895     

Met Asn Asp Ser Gly Glu Ala Ala Ile Asn Leu Leu Thr Gly Ser His 
            900                 905                 910         

Ala Asp Lys Asp Thr Asp Thr Pro Ala Tyr Lys Glu Thr Ser Ala Lys 
        915                 920                 925             

Met Glu Ile Leu Lys His Asp Gly Ile Ser Pro Leu Pro Lys Ile Asn 
    930                 935                 940                 

His Arg Asn Gly Asn Pro Gln Pro Gln Ile Gly Val Gln Val His Lys 
945                 950                 955                 960 

Lys Trp Ala Arg Lys Asp Tyr Ile Phe Pro Gly Asp Ala Val Lys 
                965                 970                 975 

<210>   466
<211>   980
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   466
Met Glu Met Ala Glu Gln Lys Lys Ile Thr Ile Asn Gly Val Glu Met 
                5                   10                  15      

Glu Ala Ser Glu Glu Gln Thr Val Leu Gln Leu Leu Asn Asn Ser Ser 
            20                  25                  30          

Ile Glu Val Pro Gln Ile Cys Tyr His Pro Ser Leu Gly Pro Ile Glu 
        35                  40                  45              

Thr Cys Asp Thr Cys Ile Val Ser Ile Asn Gly Glu Leu Lys Arg Ser 
    50                  55                  60                  

Cys Ser Ala Glu Val Lys Asp Gly Asp Val Ile Asp Thr Leu Ser Pro 
65                  70                  75                  80  

Asp Val Lys Lys Ala Gln Val Ile Gly Met Asp Lys Ile Leu Tyr Asn 
                85                  90                  95      

His Glu Leu Tyr Cys Thr Val Cys Asp Tyr Asn Asn Gly Gly Cys Glu 
            100                 105                 110         

Ile His Asn Thr Val Lys Glu Met Lys Val Asn His Gln Ser Ile Pro 
        115                 120                 125             

Phe Asp Gln Lys Pro Tyr His Lys Asp Glu Ser Asn Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Asp Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asp Val Gln Val Thr Glu Thr Leu Thr Ile Asp Trp Glu Arg Lys 
                165                 170                 175     

Arg Pro Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Ser Thr Val Cys Pro Cys Asn Ala Met 
        195                 200                 205             

Met Glu Lys Gly Met Glu Gly Glu Ala Gly Tyr Leu Thr Gly Ile Asp 
    210                 215                 220                 

Asp Glu Thr Leu Arg Pro Met Ile Glu Ile Thr Lys Gly Val Glu Thr 
225                 230                 235                 240 

Gly Tyr Gly Ser Ile Leu Ala Ile Ser Asp Met Glu Ser Ala Met Arg 
                245                 250                 255     

Asp Glu Arg Ile Lys Lys Thr Lys Thr Val Cys Thr Tyr Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Asp Val Trp Thr Lys Gly Arg Asp Ile Leu Lys Val 
        275                 280                 285             

Glu Pro Gln Glu Glu Ala Pro Ala Asn Gly Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Ile Asn Ser Glu Glu Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Glu Gly Asp His Phe Arg Glu Ala Glu Trp Glu Glu 
                325                 330                 335     

Ala Leu Thr Leu Ile Ala Ser Lys Phe Thr Asp Leu Lys Glu Glu Phe 
            340                 345                 350         

Gly Pro Asp Ser Leu Ala Phe Ile Thr Ser Ser Lys Cys Thr Asn Glu 
        355                 360                 365             

Glu Ser Tyr Leu Met Gln Lys Leu Ala Arg Gly Ile Ile Gly Thr Asn 
    370                 375                 380                 

Asn Val Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Ala Gly 
385                 390                 395                 400 

Leu Phe Arg Thr Val Gly Tyr Gly Gly Asp Ser Gly Ser Ile Ala Asp 
                405                 410                 415     

Ile Ala Gln Ala Asp Leu Val Leu Ile Ile Gly Ser Asn Thr Ser Glu 
            420                 425                 430         

Ser His Pro Val Leu Ser Thr Arg Ile Lys Arg Ala His Lys Leu Arg 
        435                 440                 445             

Gly Gln Lys Val Ile Val Ala Asp Ile Arg Lys His Glu Met Ala Glu 
    450                 455                 460                 

Arg Ser Asp Leu Phe Val Gln Pro Arg Ala Gly Ser Asp Ile Val Trp 
465                 470                 475                 480 

Leu Asn Ala Ile Ala Lys Tyr Leu Ile Glu Asn Gly Lys Ala Asp Glu 
                485                 490                 495     

Arg Phe Leu Gln Glu Arg Val Asn Gly Arg Asp Glu Tyr Val Lys Ser 
            500                 505                 510         

Leu Thr Pro Tyr Thr Leu Glu Tyr Ala Glu Glu Lys Thr Gly Ile Asp 
        515                 520                 525             

Gln Glu Thr Leu Ile Gln Met Ala Glu Met Ile Gly Gln Ala Asp Ser 
    530                 535                 540                 

Val Cys Ala Leu Trp Ala Met Gly Val Thr Gln His Ile Gly Gly Ser 
545                 550                 555                 560 

Asp Thr Ser Thr Ala Ile Ser Asn Leu Leu Leu Val Thr Gly Asn Tyr 
                565                 570                 575     

Gly Lys Pro Gly Ala Gly Ser Tyr Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Ser Asp Phe Gly Ser Met Pro Asp Arg Leu Pro Gly Tyr 
        595                 600                 605             

Glu Lys Val Thr Asp Glu Gln Val Arg Gln Lys Tyr Glu Gln Ala Trp 
    610                 615                 620                 

Gly Val Pro Leu Pro Lys Glu Pro Gly Met Thr Asn His Glu Met Ile 
625                 630                 635                 640 

Glu Lys Ile His Ser Gly Lys Leu Lys Ala Met Tyr Val Lys Gly Glu 
                645                 650                 655     

Glu Met Gly Leu Val Asp Ser Asn Ile Asn His Val His Ala Ala Tyr 
            660                 665                 670         

Glu Lys Leu Asp Phe Phe Val Val Gln Asp Ile Phe Phe Ser Arg Thr 
        675                 680                 685             

Ala Glu Phe Ala Asp Val Val Leu Pro Ala Ser Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln 
705                 710                 715                 720 

Val Phe Glu Pro Leu Gly Glu Ser Lys Pro Asp Trp Gln Ile Ile Met 
                725                 730                 735     

Glu Val Ala Asn Lys Leu Gly Ala Asp Trp His Tyr Glu His Pro Ala 
            740                 745                 750         

Asp Ile Met Glu Glu Ala Ala Lys Leu Ser Pro Ile Tyr Ala Gly Val 
        755                 760                 765             

Thr Tyr Glu Arg Leu Glu Gly Tyr Asn Ser Leu Gln Trp Pro Val Ser 
    770                 775                 780                 

Ala Asp Gly Lys Asp Ser Pro Leu Leu Phe Thr Glu Arg Phe Pro Phe 
785                 790                 795                 800 

Pro Asp Gly Lys Ala Ile Leu Tyr Pro Val His Trp Thr Glu Pro Glu 
                805                 810                 815     

Glu Phe Gly Glu Glu Tyr Asp Ile His Val Asn Asn Gly Arg Leu Leu 
            820                 825                 830         

Glu His Phe His Glu Gly Asn Leu Thr Tyr Lys Ser Lys Gly Ile Ser 
        835                 840                 845             

Lys Lys Thr Pro Glu Val Phe Leu Glu Ile Ser Pro Glu Leu Ala Ala 
    850                 855                 860                 

Glu Arg Gly Ile Gln Asp Gly Thr Leu Val Arg Leu Thr Ser Pro Phe 
865                 870                 875                 880 

Gly Asn Val Lys Val Lys Cys Leu Ile Thr Asp Arg Val Lys Gly Lys 
                885                 890                 895     

Glu Val Tyr Leu Pro Met Asn Asp Ser Gly Glu Ala Ala Ile Asn Leu 
            900                 905                 910         

Leu Thr Gly Ser His Ala Asp Lys Asp Thr Asp Thr Pro Ala Tyr Lys 
        915                 920                 925             

Glu Thr Ser Ala Lys Met Glu Ile Leu Lys Arg Asp Gly Ser Asn Pro 
    930                 935                 940                 

Leu Pro Lys Ile Asn His Arg Asn Gly Asn Pro Gln Pro Gln Ile Gly 
945                 950                 955                 960 

Val Gln Val Gln Lys Lys Trp Ala Arg Lys Asp Tyr Ile Phe Pro Gly 
                965                 970                 975     

Asp Ala Val Lys 
            980 

<210>   467
<211>   986
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   467
Met Ser Val Asp Leu Lys Arg Thr Phe Thr Leu Asp Gly Ser Pro Leu 
                5                   10                  15      

Thr Ala Thr Glu Gly Glu Thr Ile Leu Gln Ala Met Leu Ala Ala Gly 
            20                  25                  30          

Leu Asp Phe Pro His Ile Cys Tyr His Pro Ala Leu Gly Pro Ile Glu 
        35                  40                  45              

Thr Cys Asp Thr Cys Met Val Glu Val Asn Gly Asp Leu Val Arg Ala 
    50                  55                  60                  

Cys Ala Thr Pro Val Val Glu Gly Met Ser Val Arg Thr Lys Ser Val 
65                  70                  75                  80  

Ala Ala Arg Tyr Ala Arg Lys Glu Ala Met Asp Arg Ile Leu Lys Asn 
                85                  90                  95      

His Asp Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Val 
            100                 105                 110         

Val His Asn Thr Thr Met Ala Met Asp Ile Asp His Gln Ser Tyr Pro 
        115                 120                 125             

Phe Arg Glu Lys Pro Tyr Glu Val Asp Met Ser His Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Ser Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Ser Glu Val Leu Ser Ile Asp Trp Asp Arg Glu 
                165                 170                 175     

Ile Pro Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Lys Ala Gly Phe Leu Thr Gly Ile Glu 
    210                 215                 220                 

Pro Glu Pro Leu Gln Arg Met Ile Asp Val Thr Lys Ala Val Glu Pro 
225                 230                 235                 240 

Gly Tyr Arg Ala Ile Phe Ala Ile Ser Glu Ile Glu Ser His Met Arg 
                245                 250                 255     

Asn Ser Arg Ile Lys Arg Thr Lys Thr Val Cys Thr Tyr Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Asp Ile Trp Thr Lys Asp Arg Asp Ile Leu Lys Val 
        275                 280                 285             

Glu Pro Gln Met Glu Ala Pro Thr Asn Gln Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Pro Asp Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Lys Gly Asp Ala Phe His Glu Val Ser Trp Asp Glu 
                325                 330                 335     

Ala Leu Asp Phe Val Ala Lys Arg Leu Thr Glu Ile Arg Gln Gln Tyr 
            340                 345                 350         

Gly Glu Asp Ala Ile Ala Leu Ile Ser Ser Ser Lys Cys Thr Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Ala Val Leu His Thr Asn 
    370                 375                 380                 

Asn Ile Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Glu Gly 
385                 390                 395                 400 

Leu Arg Arg Thr Met Gly Tyr Gly Gly Asp Thr Gly Ser Leu His Asp 
                405                 410                 415     

Leu Ala Met Ala Asp Leu Leu Ile Ile Ile Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Ser His Pro Val Phe Ser Thr Arg Met Arg Arg Ala Lys Lys Lys Tyr 
        435                 440                 445             

Gly Gln Lys His Ile Val Ile Asp Leu Arg Glu His Asp Met Ala His 
    450                 455                 460                 

Arg Ala Asp Leu Phe Val Arg Pro Asn Pro Gly Thr Asp Leu Val Leu 
465                 470                 475                 480 

Ile Ser Ala Val Thr Arg Tyr Ile Ile Asp Gln Gly Trp His Asp Ala 
                485                 490                 495     

Asp Phe Val Arg Asp Arg Val Asp Gly Phe Glu Asp Phe Val Arg Ser 
            500                 505                 510         

Leu Glu Pro Tyr Thr Leu Glu Tyr Ala Glu Arg Val Thr Gly Val Pro 
        515                 520                 525             

Arg Asp Thr Val Ile Gln Ile Ala Thr Met Ile His Glu Ala Lys Ser 
    530                 535                 540                 

Thr Cys Ile Cys Trp Ala Met Gly Val Thr Gln His Lys Gly Gly Ser 
545                 550                 555                 560 

Glu Thr Ser Thr Ala Ile Cys Asn Leu Leu Leu Val Thr Gly Asn Val 
                565                 570                 575     

Gly Arg Pro Gly Thr Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Gly Asp Met Gly Cys Ser Pro Val Tyr Met Pro Gly Tyr 
        595                 600                 605             

Glu Arg Val Asp Asp Pro Ala Val Arg Ala Lys Tyr Glu Thr Ala Trp 
    610                 615                 620                 

Val Val Glu Leu Pro Thr Ser Lys Gly Leu Asp Asn His Glu Met Val 
625                 630                 635                 640 

Asp Ala Ile His Glu Gly Lys Leu Arg Ala Leu Ile Ile Gln Gly Glu 
                645                 650                 655     

Glu Met Ala Leu Val Asp Ser Asn Ser His Tyr Val Arg Glu Ala Phe 
            660                 665                 670         

Ala Lys Leu Asp Leu Leu Val Val Ile Asp Val Phe Phe Ser Lys Thr 
        675                 680                 685             

Ala Glu Tyr Ala Asp Val Val Leu Ala Ala Ser Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln 
705                 710                 715                 720 

Val Phe Glu Pro Leu Gly Glu Ser Arg Pro Asp Trp Val Ile Leu Arg 
                725                 730                 735     

Asp Leu Ala Asn Arg Leu Gly Ala Asn Trp Thr Tyr Ala His Pro Ser 
            740                 745                 750         

Glu Ile Leu Glu Glu Met Ala Ser Leu Ala Ala Leu Met Gln Gly Val 
        755                 760                 765             

Arg Trp Asp Arg Leu Glu Gly Tyr Arg Ser Leu Gln Trp Pro Val His 
    770                 775                 780                 

Pro Asp Gly Thr Asp Thr Pro Leu Leu Tyr Thr Asn Gly Phe Pro Phe 
785                 790                 795                 800 

Pro Asn Gly Lys Ala Arg Leu Val Pro Ala Arg Trp Ile Glu Pro Thr 
                805                 810                 815     

Ala Phe Glu Pro Glu Tyr Asp Leu His Leu Asn Asn Gly Arg Met Leu 
            820                 825                 830         

Glu His Phe His Glu Gly Asn Leu Thr Tyr Arg Val His Gly Leu Lys 
        835                 840                 845             

Glu Lys Val Pro Thr Thr Tyr Leu Glu Val Ser Pro Glu Leu Ala Lys 
    850                 855                 860                 

Glu Arg Gly Ile Glu Thr Gly Ala Leu Val Arg Leu Ile Ser Pro Tyr 
865                 870                 875                 880 

Gly Glu Leu Lys Leu Pro Val Val Val Thr Asp Arg Val Lys Gly Lys 
                885                 890                 895     

Gln Met Tyr Leu Pro Met Asn Thr Ser Asn Asp Glu Glu Ala Ile Asn 
            900                 905                 910         

Ile Leu Thr Ser Ser Glu Ser Asp Glu Thr Thr His Thr Pro Ala Tyr 
        915                 920                 925             

Lys Glu Leu Gln Val Arg Met Glu Val Ile Arg Pro Arg Gly Glu Ser 
    930                 935                 940                 

Pro Met Thr Arg Phe Asn Phe Arg Met His Arg Pro Asn Pro Gln Ser 
945                 950                 955                 960 

Gly Val Arg Val Glu Arg Lys Trp Ser Arg Arg Gly Tyr Val Pro Val 
                965                 970                 975     

Ala Glu Ala Ala Lys Glu Lys Ala Arg Gly 
            980                 985     

<210>   468
<211>   986
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   468
Met Ser Val Asp Leu Lys Arg Thr Phe Thr Leu Asp Gly Ser Pro Leu 
                5                   10                  15      

Thr Ala Thr Glu Gly Glu Thr Ile Leu Gln Ala Met Leu Ala Ala Gly 
            20                  25                  30          

Leu Asp Phe Pro His Ile Cys Tyr His Pro Ala Leu Gly Pro Ile Glu 
        35                  40                  45              

Thr Cys Asp Thr Cys Met Val Glu Val Asn Gly Asp Leu Val Arg Ala 
    50                  55                  60                  

Cys Ala Thr Pro Val Val Glu Gly Met Ser Val Arg Thr Lys Ser Val 
65                  70                  75                  80  

Ala Ala Arg Tyr Ala Arg Lys Glu Ala Met Asp Arg Ile Leu Lys Asn 
                85                  90                  95      

His Asp Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Val 
            100                 105                 110         

Val His Asn Thr Thr Met Ala Met Asp Ile Asp His Gln Ser Tyr Pro 
        115                 120                 125             

Phe Arg Glu Lys Pro Tyr Glu Val Asp Met Ser His Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Ser Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Ser Glu Val Leu Ser Ile Asp Trp Asp Arg Glu 
                165                 170                 175     

Ile Pro Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Lys Ala Gly Phe Leu Thr Gly Ile Glu 
    210                 215                 220                 

Pro Glu Pro Leu Gln Arg Met Ile Asp Val Thr Lys Ala Val Glu Pro 
225                 230                 235                 240 

Gly Tyr Arg Ala Ile Phe Ala Ile Ser Glu Ile Glu Ser His Met Arg 
                245                 250                 255     

Asn Ser Arg Ile Lys Arg Thr Lys Thr Val Cys Thr Tyr Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Asp Ile Trp Thr Lys Asp Arg Asp Ile Leu Lys Val 
        275                 280                 285             

Glu Pro Gln Met Glu Ala Pro Thr Asn Gln Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Pro Asp Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Lys Gly Asp Ala Phe His Glu Val Ser Trp Asp Glu 
                325                 330                 335     

Ala Leu Asp Phe Val Ala Lys Arg Leu Thr Glu Ile Arg Gln Gln Tyr 
            340                 345                 350         

Gly Asp Asp Ala Ile Ala Leu Ile Ser Ser Ser Lys Cys Thr Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Ala Val Leu His Thr Asn 
    370                 375                 380                 

Asn Ile Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Glu Gly 
385                 390                 395                 400 

Leu Arg Arg Thr Met Gly Tyr Gly Gly Asp Thr Gly Ser Leu His Asp 
                405                 410                 415     

Leu Ala Met Ala Asp Leu Leu Ile Ile Ile Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Ser His Pro Val Phe Ser Thr Arg Met Arg Arg Ala Lys Lys Lys Tyr 
        435                 440                 445             

Gly Gln Lys His Ile Val Ile Asp Leu Arg Glu His Asp Met Ala His 
    450                 455                 460                 

Arg Ala Asp Leu Phe Val Arg Pro Asn Pro Gly Thr Asp Leu Val Leu 
465                 470                 475                 480 

Ile Ser Ala Val Thr Arg Tyr Ile Ile Asp Gln Gly Trp His Asp Ala 
                485                 490                 495     

Asp Phe Val Arg Asp Arg Val Asp Gly Phe Glu Asp Phe Val Arg Ser 
            500                 505                 510         

Leu Glu Pro Tyr Thr Leu Glu Tyr Ala Glu Arg Val Thr Gly Val Pro 
        515                 520                 525             

Arg Asp Thr Val Ile Gln Ile Ala Thr Met Ile His Glu Ala Lys Ser 
    530                 535                 540                 

Thr Cys Ile Cys Trp Ala Met Gly Val Thr Gln His Lys Gly Gly Ser 
545                 550                 555                 560 

Glu Thr Ser Thr Ala Ile Cys Asn Leu Leu Leu Val Thr Gly Asn Val 
                565                 570                 575     

Gly Arg Pro Gly Thr Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Gly Asp Met Gly Cys Ser Pro Val Tyr Met Pro Gly Tyr 
        595                 600                 605             

Glu Arg Val Asp Asp Pro Ala Val Arg Ala Lys Tyr Glu Thr Ala Trp 
    610                 615                 620                 

Val Val Glu Leu Pro Thr Ser Lys Gly Leu Asp Asn His Glu Met Val 
625                 630                 635                 640 

Asp Ala Ile His Glu Gly Lys Leu Arg Ala Leu Ile Ile Gln Gly Glu 
                645                 650                 655     

Glu Met Ala Leu Val Asp Ser Asn Ser His Tyr Val Arg Glu Ala Phe 
            660                 665                 670         

Ala Lys Leu Asp Leu Leu Val Val Ile Asp Val Phe Phe Ser Lys Thr 
        675                 680                 685             

Ala Glu Tyr Ala Asp Val Val Leu Ala Ala Ser Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln 
705                 710                 715                 720 

Val Phe Glu Pro Leu Gly Glu Ser Arg Pro Asp Trp Val Ile Leu Arg 
                725                 730                 735     

Asp Leu Ala Asn Arg Leu Gly Ala Asn Trp Thr Tyr Ala His Pro Ser 
            740                 745                 750         

Glu Ile Leu Glu Glu Met Ala Ser Leu Ala Ala Leu Met Gln Gly Val 
        755                 760                 765             

Arg Trp Asp Arg Leu Glu Gly Tyr Arg Ser Leu Gln Trp Pro Val His 
    770                 775                 780                 

Pro Asp Gly Thr Asp Thr Pro Leu Leu Tyr Thr Asn Gly Phe Pro Phe 
785                 790                 795                 800 

Pro Asn Gly Lys Ala Arg Leu Val Pro Ala Arg Trp Ile Glu Pro Thr 
                805                 810                 815     

Ala Phe Glu Pro Glu Tyr Asp Leu His Leu Asn Asn Gly Arg Met Leu 
            820                 825                 830         

Glu His Phe His Glu Gly Asn Leu Thr Tyr Arg Val His Gly Leu Arg 
        835                 840                 845             

Glu Lys Val Pro Thr Thr Tyr Leu Glu Val Ser Pro Glu Leu Ala Lys 
    850                 855                 860                 

Glu Arg Gly Ile Glu Thr Gly Ala Leu Val Arg Leu Ile Ser Pro Tyr 
865                 870                 875                 880 

Gly Glu Leu Lys Leu Pro Val Val Val Thr Asp Arg Val Lys Gly Lys 
                885                 890                 895     

Gln Met Tyr Leu Pro Met Asn Thr Ser Asn Asp Glu Glu Ala Ile Asn 
            900                 905                 910         

Ile Leu Thr Ser Ser Glu Ser Asp Glu Thr Thr His Thr Pro Ala Tyr 
        915                 920                 925             

Lys Glu Leu Gln Val Arg Met Glu Val Ile Arg Pro Arg Gly Glu Ser 
    930                 935                 940                 

Pro Met Thr Arg Phe Asn Phe Arg Met His Arg Pro Asn Pro Gln Ser 
945                 950                 955                 960 

Gly Val Arg Val Glu Arg Lys Trp Ser Arg Arg Gly Tyr Val Pro Val 
                965                 970                 975     

Ala Glu Ala Ala Lys Glu Lys Ala Arg Gly 
            980                 985     

<210>   469
<211>   986
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   469
Met Ser Val Asp Leu Lys Arg Thr Phe Thr Leu Asp Gly Ser Pro Leu 
                5                   10                  15      

Thr Ala Thr Glu Gly Glu Thr Ile Leu Gln Ala Met Leu Ala Ala Gly 
            20                  25                  30          

Leu Asp Phe Pro His Ile Cys Tyr His Pro Ala Leu Gly Pro Ile Glu 
        35                  40                  45              

Thr Cys Asp Thr Cys Met Val Glu Val Asn Gly Asp Leu Val Arg Ala 
    50                  55                  60                  

Cys Ala Thr Pro Val Val Glu Gly Met Ser Val Arg Thr Lys Ser Val 
65                  70                  75                  80  

Ala Ala Arg Tyr Ala Arg Lys Glu Ala Met Asp Arg Ile Leu Lys Asn 
                85                  90                  95      

His Asp Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Val 
            100                 105                 110         

Val His Asn Thr Thr Met Ala Met Asp Ile Asp His Gln Ser Tyr Pro 
        115                 120                 125             

Phe Arg Glu Lys Pro Tyr Glu Val Asp Met Ser His Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Ser Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Ser Glu Val Leu Ser Ile Asp Trp Asp Arg Glu 
                165                 170                 175     

Ile Pro Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Lys Ala Gly Phe Leu Thr Gly Ile Glu 
    210                 215                 220                 

Pro Glu Pro Leu Gln Arg Met Ile Asp Val Thr Lys Ala Val Glu Pro 
225                 230                 235                 240 

Gly Tyr Arg Ala Ile Phe Ala Ile Ser Glu Ile Glu Ser His Met Arg 
                245                 250                 255     

Asn Ser Arg Ile Lys Arg Thr Lys Thr Val Cys Thr Tyr Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Asp Ile Trp Thr Lys Asp Arg Asp Ile Leu Lys Val 
        275                 280                 285             

Glu Pro Gln Met Glu Ala Pro Thr Asn Gln Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Pro Asp Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Lys Gly Asp Ala Phe His Glu Val Ser Trp Asp Glu 
                325                 330                 335     

Ala Leu Asp Phe Val Ala Lys Arg Leu Thr Glu Ile Arg Gln Gln Tyr 
            340                 345                 350         

Gly Asp Asp Ala Ile Ala Leu Ile Ser Ser Ser Lys Cys Thr Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Ala Val Leu His Thr Asn 
    370                 375                 380                 

Asn Ile Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Glu Gly 
385                 390                 395                 400 

Leu Arg Arg Thr Met Gly Tyr Gly Gly Asp Thr Gly Ser Leu His Asp 
                405                 410                 415     

Leu Ala Met Ala Asp Leu Leu Ile Ile Ile Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Ser His Pro Val Phe Ser Thr Arg Met Arg Arg Ala Lys Lys Lys Tyr 
        435                 440                 445             

Gly Gln Lys His Ile Val Ile Asp Leu Arg Glu His Asp Met Ala His 
    450                 455                 460                 

Arg Ala Asp Leu Phe Val Arg Pro Asn Pro Gly Thr Asp Leu Val Leu 
465                 470                 475                 480 

Ile Ser Ala Val Thr Arg Tyr Ile Ile Asp Gln Gly Trp His Asp Ala 
                485                 490                 495     

Asp Phe Val Arg Asp Arg Val Asp Gly Phe Glu Asp Phe Val Arg Ser 
            500                 505                 510         

Leu Glu Pro Tyr Thr Leu Glu Tyr Ala Glu Arg Val Thr Gly Val Pro 
        515                 520                 525             

Arg Asp Thr Val Ile Gln Ile Ala Thr Met Ile His Glu Ala Lys Ser 
    530                 535                 540                 

Thr Cys Ile Cys Trp Ala Met Gly Val Thr Gln His Lys Gly Gly Ser 
545                 550                 555                 560 

Glu Thr Ser Thr Ala Ile Cys Asn Leu Leu Leu Val Thr Gly Asn Val 
                565                 570                 575     

Gly Arg Pro Gly Thr Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Gly Asp Met Gly Cys Ser Pro Val Tyr Met Pro Gly Tyr 
        595                 600                 605             

Glu Arg Val Asp Asp Pro Ala Val Arg Ala Lys Tyr Glu Thr Ala Trp 
    610                 615                 620                 

Val Val Asp Leu Pro Thr Ser Lys Gly Leu Asp Asn His Glu Met Val 
625                 630                 635                 640 

Asp Ala Ile His Glu Gly Lys Leu Arg Ala Leu Ile Ile Gln Gly Glu 
                645                 650                 655     

Glu Met Ala Leu Val Asp Ser Asn Ser His Tyr Val Arg Glu Ala Phe 
            660                 665                 670         

Ala Lys Leu Asp Leu Leu Val Val Ile Asp Val Phe Phe Ser Lys Thr 
        675                 680                 685             

Ala Glu Tyr Ala Asp Val Val Leu Ala Ala Ser Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln 
705                 710                 715                 720 

Val Phe Glu Pro Leu Gly Glu Ser Arg Pro Asp Trp Val Ile Leu Arg 
                725                 730                 735     

Asp Leu Ala Asn Arg Leu Gly Ala Asn Trp Thr Tyr Ala His Pro Ser 
            740                 745                 750         

Glu Ile Leu Glu Glu Met Ala Ser Leu Ala Ala Leu Met Gln Gly Val 
        755                 760                 765             

Arg Trp Asp Arg Leu Glu Gly Tyr Arg Ser Leu Gln Trp Pro Val His 
    770                 775                 780                 

Pro Asp Gly Thr Asp Thr Pro Leu Leu Tyr Thr Asn Gly Phe Pro Phe 
785                 790                 795                 800 

Pro Asn Gly Lys Ala Arg Leu Val Pro Ala Arg Trp Ile Glu Pro Thr 
                805                 810                 815     

Ala Phe Glu Pro Glu Tyr Asp Leu His Leu Asn Asn Gly Arg Met Leu 
            820                 825                 830         

Glu His Phe His Glu Gly Asn Leu Thr Tyr Arg Val His Gly Leu Lys 
        835                 840                 845             

Glu Lys Val Pro Thr Thr Tyr Leu Glu Val Ser Pro Glu Leu Ala Lys 
    850                 855                 860                 

Glu Arg Gly Ile Glu Thr Gly Ala Leu Val Arg Leu Ile Ser Pro Tyr 
865                 870                 875                 880 

Gly Glu Leu Lys Leu Pro Val Val Val Thr Asp Arg Val Lys Gly Lys 
                885                 890                 895     

Gln Met Tyr Leu Pro Met Asn Thr Ser Asn Asp Glu Glu Ala Ile Asn 
            900                 905                 910         

Ile Leu Thr Ser Ser Glu Ser Asp Glu Thr Thr His Thr Pro Ala Tyr 
        915                 920                 925             

Lys Glu Leu Gln Val Arg Met Glu Val Ile Arg Pro Arg Gly Glu Ser 
    930                 935                 940                 

Pro Met Thr Arg Phe Asn Phe Arg Met His Arg Pro Asn Pro Gln Ser 
945                 950                 955                 960 

Gly Val Arg Val Glu Arg Lys Trp Ser Arg Arg Gly Tyr Val Pro Val 
                965                 970                 975     

Ala Glu Ala Ala Lys Glu Lys Ala Arg Gly 
            980                 985     

<210>   470
<211>   986
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   470
Met Ser Val Asp Leu Lys Arg Thr Phe Thr Leu Asp Gly Ser Pro Leu 
                5                   10                  15      

Thr Ala Thr Glu Gly Glu Thr Ile Leu Gln Ala Met Leu Ala Ala Gly 
            20                  25                  30          

Leu Asp Phe Pro His Ile Cys Tyr His Pro Ala Leu Gly Pro Ile Glu 
        35                  40                  45              

Thr Cys Asp Thr Cys Met Val Glu Val Asn Gly Asp Leu Val Arg Ala 
    50                  55                  60                  

Cys Ala Thr Pro Val Val Glu Gly Met Ser Val Arg Thr Lys Ser Val 
65                  70                  75                  80  

Ala Ala Arg Tyr Ala Arg Lys Glu Ala Met Asp Arg Ile Leu Lys Asn 
                85                  90                  95      

His Asp Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Val 
            100                 105                 110         

Val His Asn Thr Thr Met Ala Met Asp Ile Asp His Gln Ser Tyr Pro 
        115                 120                 125             

Phe Arg Glu Lys Pro Tyr Glu Val Asp Met Ser His Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Ser Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Ser Glu Val Leu Ser Ile Asp Trp Asp Arg Glu 
                165                 170                 175     

Ile Pro Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Lys Ala Gly Phe Leu Thr Gly Ile Glu 
    210                 215                 220                 

Pro Glu Pro Leu Gln Arg Met Ile Asp Val Thr Lys Ala Val Glu Pro 
225                 230                 235                 240 

Gly Tyr Arg Ala Ile Phe Ala Ile Ser Glu Ile Glu Ser His Met Arg 
                245                 250                 255     

Asn Ser Arg Ile Lys Arg Thr Lys Thr Val Cys Thr Tyr Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Asp Ile Trp Thr Lys Asp Arg Asp Ile Leu Lys Val 
        275                 280                 285             

Glu Pro Gln Met Glu Ala Pro Thr Asn Gln Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Pro Asp Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Lys Gly Asp Ala Phe His Glu Val Ser Trp Asp Glu 
                325                 330                 335     

Ala Leu Asp Phe Val Ala Lys Arg Leu Thr Glu Ile Arg Gln Gln Tyr 
            340                 345                 350         

Gly Asp Asp Ala Ile Ala Leu Ile Ser Ser Ser Lys Cys Thr Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Ala Val Leu His Thr Asn 
    370                 375                 380                 

Asn Ile Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Glu Gly 
385                 390                 395                 400 

Leu Arg Arg Thr Met Gly Tyr Gly Gly Asp Thr Gly Ser Leu His Asp 
                405                 410                 415     

Leu Ala Met Ala Asp Leu Leu Ile Ile Ile Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Ser His Pro Val Phe Ser Thr Arg Met Arg Arg Ala Lys Lys Lys Tyr 
        435                 440                 445             

Gly Gln Lys His Ile Val Ile Asp Leu Arg Glu His Asp Met Ala His 
    450                 455                 460                 

Arg Ala Asp Leu Phe Val Arg Pro Asn Pro Gly Thr Asp Leu Val Leu 
465                 470                 475                 480 

Ile Ser Ala Val Thr Arg Tyr Ile Ile Asp Gln Gly Trp His Asp Ala 
                485                 490                 495     

Asp Phe Val Arg Asp Arg Val Asp Gly Phe Glu Asp Phe Val Arg Ser 
            500                 505                 510         

Leu Glu Pro Tyr Thr Leu Glu Tyr Ala Glu Arg Val Thr Gly Val Pro 
        515                 520                 525             

Arg Asp Thr Val Ile Gln Ile Ala Thr Met Ile His Glu Ala Lys Ser 
    530                 535                 540                 

Thr Cys Ile Cys Trp Ala Met Gly Val Thr Gln His Lys Gly Gly Ser 
545                 550                 555                 560 

Glu Thr Ser Thr Ala Ile Cys Asn Leu Leu Leu Val Thr Gly Asn Val 
                565                 570                 575     

Gly Arg Pro Gly Thr Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Gly Asp Met Gly Cys Ser Pro Val Tyr Met Pro Gly Tyr 
        595                 600                 605             

Glu Arg Val Asp Asp Pro Ala Val Arg Ala Lys Tyr Glu Thr Ala Trp 
    610                 615                 620                 

Val Val Glu Leu Pro Thr Ser Lys Gly Leu Asp Asn His Glu Met Val 
625                 630                 635                 640 

Asp Ala Ile His Glu Gly Lys Leu Arg Ala Leu Ile Ile Gln Gly Glu 
                645                 650                 655     

Glu Met Ala Leu Val Asp Ser Asn Ser His Tyr Val Arg Glu Ala Phe 
            660                 665                 670         

Ala Lys Leu Asp Leu Leu Val Val Ile Asp Val Phe Phe Ser Lys Thr 
        675                 680                 685             

Ala Glu Tyr Ala Asp Val Val Leu Ala Ala Ser Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln 
705                 710                 715                 720 

Val Phe Glu Pro Leu Gly Glu Ser Arg Pro Asp Trp Val Ile Leu Arg 
                725                 730                 735     

Asp Leu Ala Asn Lys Leu Gly Ala Asn Trp Thr Tyr Ala His Pro Ser 
            740                 745                 750         

Glu Ile Leu Glu Glu Met Ala Ser Leu Ala Ala Leu Met Gln Gly Val 
        755                 760                 765             

Arg Trp Asp Arg Leu Glu Gly Tyr Arg Ser Leu Gln Trp Pro Val His 
    770                 775                 780                 

Pro Asp Gly Thr Asp Thr Pro Leu Leu Tyr Thr Asn Gly Phe Pro Phe 
785                 790                 795                 800 

Pro Asn Gly Lys Ala Arg Leu Val Pro Ala Arg Trp Ile Glu Pro Thr 
                805                 810                 815     

Ala Phe Glu Pro Glu Tyr Asp Leu His Leu Asn Asn Gly Arg Met Leu 
            820                 825                 830         

Glu His Phe His Glu Gly Asn Leu Thr Tyr Arg Val His Gly Leu Lys 
        835                 840                 845             

Glu Lys Val Pro Thr Thr Tyr Leu Glu Val Ser Pro Glu Leu Ala Lys 
    850                 855                 860                 

Glu Arg Gly Ile Glu Thr Gly Ala Leu Val Arg Leu Ile Ser Pro Tyr 
865                 870                 875                 880 

Gly Glu Leu Lys Leu Pro Val Val Val Thr Asp Arg Val Lys Gly Lys 
                885                 890                 895     

Gln Met Tyr Leu Pro Met Asn Thr Ser Asn Asp Glu Glu Ala Ile Asn 
            900                 905                 910         

Ile Leu Thr Ser Ser Glu Ser Asp Glu Thr Thr His Thr Pro Ala Tyr 
        915                 920                 925             

Lys Glu Leu Gln Val Arg Met Glu Val Ile Arg Pro Arg Gly Glu Ser 
    930                 935                 940                 

Pro Met Thr Arg Phe Asn Phe Arg Met His Arg Pro Asn Pro Gln Ser 
945                 950                 955                 960 

Gly Val Arg Val Glu Arg Lys Trp Ser Arg Arg Gly Tyr Val Pro Val 
                965                 970                 975     

Ala Glu Ala Ala Lys Glu Lys Ala Arg Gly 
            980                 985     

<210>   471
<211>   986
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   471
Met Ser Val Asp Leu Lys Arg Thr Phe Thr Leu Asp Gly Ser Pro Leu 
                5                   10                  15      

Thr Ala Thr Glu Gly Glu Thr Ile Leu Gln Ala Met Leu Ala Ala Gly 
            20                  25                  30          

Leu Asp Phe Pro His Ile Cys Tyr His Pro Ala Leu Gly Pro Ile Glu 
        35                  40                  45              

Thr Cys Asp Thr Cys Met Val Glu Val Asn Gly Asp Leu Val Arg Ala 
    50                  55                  60                  

Cys Ala Thr Pro Val Val Glu Gly Met Ser Val Arg Thr Lys Ser Val 
65                  70                  75                  80  

Ala Ala Arg Tyr Ala Arg Lys Glu Ala Met Asp Arg Ile Leu Lys Asn 
                85                  90                  95      

His Asp Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Val 
            100                 105                 110         

Val His Asn Thr Thr Met Ala Met Asp Ile Asp His Gln Ser Tyr Pro 
        115                 120                 125             

Phe Arg Glu Lys Pro Tyr Glu Val Asp Met Ser His Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Ser Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Ser Glu Val Leu Ser Ile Asp Trp Asp Arg Glu 
                165                 170                 175     

Ile Pro Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Lys Ala Gly Phe Leu Thr Gly Ile Glu 
    210                 215                 220                 

Pro Glu Pro Leu Gln Arg Met Ile Asp Val Thr Lys Ala Val Glu Pro 
225                 230                 235                 240 

Gly Tyr Arg Ala Ile Phe Ala Ile Ser Glu Ile Glu Ser His Met Arg 
                245                 250                 255     

Asn Ser Arg Ile Lys Arg Thr Lys Thr Val Cys Thr Tyr Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Asp Ile Trp Thr Lys Asp Arg Asp Ile Leu Lys Val 
        275                 280                 285             

Glu Pro Gln Met Glu Ala Pro Thr Asn Gln Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Pro Asp Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Lys Gly Asp Ala Phe His Glu Val Ser Trp Asp Glu 
                325                 330                 335     

Ala Leu Asp Phe Val Ala Lys Arg Leu Thr Glu Ile Arg Gln Gln Tyr 
            340                 345                 350         

Gly Asp Asp Ala Ile Ala Leu Ile Ser Ser Ser Lys Cys Thr Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Ala Val Leu His Thr Asn 
    370                 375                 380                 

Asn Ile Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Glu Gly 
385                 390                 395                 400 

Leu Arg Arg Thr Met Gly Tyr Gly Gly Asp Thr Gly Ser Leu His Asp 
                405                 410                 415     

Leu Ala Met Ala Asp Leu Leu Ile Ile Ile Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Ser His Pro Val Phe Ser Thr Arg Met Arg Arg Ala Lys Lys Lys Tyr 
        435                 440                 445             

Gly Gln Lys His Ile Val Ile Asp Leu Arg Glu His Asp Met Ala His 
    450                 455                 460                 

Arg Ala Asp Leu Phe Val Arg Pro Asn Pro Gly Thr Asp Leu Val Leu 
465                 470                 475                 480 

Ile Ser Ala Val Thr Arg Tyr Ile Ile Asp Gln Gly Trp His Asp Ala 
                485                 490                 495     

Asp Phe Val Arg Asp Arg Val Asp Gly Phe Glu Asp Phe Val Arg Ser 
            500                 505                 510         

Leu Glu Pro Tyr Thr Leu Glu Tyr Ala Glu Arg Val Thr Gly Val Pro 
        515                 520                 525             

Arg Asp Thr Val Ile Gln Ile Ala Thr Met Ile His Glu Ala Lys Ser 
    530                 535                 540                 

Thr Cys Ile Cys Trp Ala Met Gly Val Thr Gln His Lys Gly Gly Ser 
545                 550                 555                 560 

Glu Thr Ser Thr Ala Ile Cys Asn Leu Leu Leu Val Thr Gly Asn Val 
                565                 570                 575     

Gly Arg Pro Gly Thr Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Gly Asp Met Gly Cys Ser Pro Val Tyr Met Pro Gly Tyr 
        595                 600                 605             

Glu Arg Val Asp Asp Pro Ala Val Arg Ala Lys Tyr Glu Thr Ala Trp 
    610                 615                 620                 

Val Val Glu Leu Pro Thr Ser Lys Gly Leu Asp Asn His Glu Met Val 
625                 630                 635                 640 

Asp Ala Ile His Glu Gly Lys Leu Arg Ala Leu Ile Ile Gln Gly Glu 
                645                 650                 655     

Glu Met Ala Leu Val Asp Ser Asn Ser His Tyr Val Arg Glu Ala Phe 
            660                 665                 670         

Ala Lys Leu Asp Leu Leu Val Val Ile Asp Val Phe Phe Ser Lys Thr 
        675                 680                 685             

Ala Glu Tyr Ala Asp Val Val Leu Ala Ala Ser Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln 
705                 710                 715                 720 

Val Phe Glu Pro Leu Gly Glu Ser Arg Pro Asp Trp Val Ile Leu Arg 
                725                 730                 735     

Asp Leu Ala Asn Arg Leu Gly Ala Asn Trp Thr Tyr Ala His Pro Ser 
            740                 745                 750         

Glu Ile Leu Glu Glu Met Ala Ser Leu Ala Ala Leu Met Gln Gly Val 
        755                 760                 765             

Arg Trp Asp Arg Leu Glu Gly Tyr Arg Ser Leu Gln Trp Pro Val His 
    770                 775                 780                 

Pro Asp Gly Thr Asp Thr Pro Leu Leu Tyr Thr Asn Gly Phe Pro Phe 
785                 790                 795                 800 

Pro Asn Gly Lys Ala Arg Leu Val Pro Ala Arg Trp Ile Glu Pro Thr 
                805                 810                 815     

Ala Phe Glu Pro Glu Tyr Asp Leu His Leu Asn Asn Gly Arg Met Leu 
            820                 825                 830         

Glu His Phe His Glu Gly Asn Leu Thr Tyr Arg Val His Gly Leu Lys 
        835                 840                 845             

Glu Lys Val Pro Thr Thr Tyr Leu Glu Val Ser Pro Glu Leu Ala Lys 
    850                 855                 860                 

Glu Arg Gly Ile Glu Thr Gly Ala Leu Val Arg Leu Ile Ser Pro Tyr 
865                 870                 875                 880 

Gly Glu Leu Lys Leu Pro Val Val Val Thr Asp Arg Val Lys Gly Lys 
                885                 890                 895     

Gln Met Tyr Leu Pro Met Asn Thr Ser Asn Asp Glu Glu Ala Ile Asn 
            900                 905                 910         

Ile Leu Thr Ser Ser Glu Ser Asp Glu Thr Thr His Thr Pro Ala Tyr 
        915                 920                 925             

Lys Glu Leu Gln Val Arg Met Glu Val Ile Arg Pro Arg Gly Glu Ser 
    930                 935                 940                 

Pro Met Thr Arg Phe Asn Phe Arg Met His Arg Pro Asn Pro Gln Ser 
945                 950                 955                 960 

Gly Val Arg Val Glu Arg Lys Trp Ser Arg Arg Gly Tyr Val Pro Val 
                965                 970                 975     

Ala Glu Ala Ala Lys Glu Lys Ala Lys Gly 
            980                 985     

<210>   472
<211>   2961
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   472
atgagcgttg atttgaagcg aaccttcacg ctggacggat cgcccctgac ggcgaccgag       60

ggggagacca tcctgcaggc gatgttggcg gctggcctag actttcccca catctgttat      120

catcctgcgc ttggccccat cgagacctgc gacacgtgca tggtagaggt gaatggcgat      180

ctcgtccggg cgtgcgcgac cccggtcgtc gagggcatgt cggtccgcac caaatccgtg      240

gccgcgcggt acgcgcgcaa ggaggcgatg gatcgcatcc tgaaaaacca cgacctctac      300

tgcacggtct gcgacaacaa caacggcaac tgcgtggtgc acaacaccac gatggcgatg      360

gacatcgacc atcagtcgta cccgttccgc gagaagccgt acgaagtcga catgtcgcac      420

ccgttctacc ggtacgatcc gagccagtgc atcctctgcg ggcgatgcgt cgaggcgtgt      480

cagaacctgc aggtcagtga agtgctttcc atcgactggg atcgcgagat tccgcgcgtc      540

atctgggaca atgacgtccc catcaacgag tcgtcgtgcg tctcgtgcgg ccactgcgtg      600

accgtctgcc cctgcaatgc gctcatggag aagtcgatgc tcggcaaggc tggattcctc      660

acgggcatcg aaccggagcc gctgcagcgg atgatcgacg tgacgaaggc ggtggagccc      720

ggctaccgcg ccatctttgc catctccgag atcgagagcc acatgcggaa ttcccgcatc      780

aagcgcacga agaccgtgtg cacgtactgc ggcgtgggct gctcgtttga catctggacg      840

aaggaccggg acatcctgaa ggtcgaaccg cagatggagg cgccgaccaa ccagatctcc      900

acctgcgtca agggaaagtt cggctgggat tttgtgaata gcccggaccg cctcacgaag      960

cccctcatcc gcaagggcga cgcgtttcat gaggtgtcgt gggacgaggc cttggacttc     1020

gtcgcgaagc gcctgacgga aatccgccag caatacggcg aagatgccat cgcattgatc     1080

tcgtcctcga agtgcaccaa cgaggaaaac tacctgatgc aaaaactcgc ccgcgccgtt     1140

ctccacacga acaacatcga caactgttca cggtactgcc agtcgcccgc caccgagggt     1200

ctgcgccgga ccatgggtta cggcggcgac accggctcgc tccacgatct cgccatggcc     1260

gatctgctca tcatcattgg cgcgaacccg gccgagtccc accccgtctt ctcgacccgc     1320

atgcggcggg ccaagaagaa gtacggccag aagcacatcg tgatcgacct tcgcgaacac     1380

gatatggcgc accgcgccga cctgttcgtc cggccgaatc ctggaaccga tctggtgctc     1440

atctcggccg tgacgaggta catcatcgac cagggttggc acgacgccga cttcgtgcgc     1500

gatcgcgtcg acggttttga agatttcgtc cgctcgctcg agccgtatac gctcgagtac     1560

gccgagcgcg tgacgggcgt gccgcgcgac accgtgattc agatcgccac gatgatccat     1620

gaggccaagt ccacctgcat ctgttgggcg atgggcgtga cgcagcacaa ggggggcagc     1680

gagaccagca ccgccatctg caacctcctg ctcgtcacgg ggaacgtcgg gcgcccaggc     1740

accggggcct atccgctccg aggccacaac aacgtccaag gggcgggcga catgggctgc     1800

agcccggtgt acatgccggg ctacgagcgc gtcgatgatc cggccgtgcg agccaagtac     1860

gagacggcct gggtcgtgga gctgccgacg agcaaggggc tcgacaacca cgagatggtg     1920

gacgcgattc acgagggcaa acttcgggcc cttatcattc agggcgagga gatggcgctc     1980

gtcgactcga attcgcacta cgtccgcgag gcgtttgcga agctggatct gctcgtcgtg     2040

atcgacgtgt tcttcagcaa gactgctgag tacgccgacg tggtgctcgc cgcgagcccg     2100

agcctggaga aggagggcac gttcacgaac acggaacggc gcatccagcg cctgtaccag     2160

gtgttcgaac cgctcggcga atctcgcccg gactgggtca ttctgcgcga tctcgccaat     2220

cgcctgggcg ccaactggac gtacgcgcac ccgtccgaaa tcctcgagga aatggcgagc     2280

ttggcggcgc tgatgcaggg ggttcgctgg gatcgactgg agggctatcg cagcctgcag     2340

tggccggttc atcccgacgg gaccgatacg ccgctgctct acacgaacgg tttcccgttc     2400

ccgaatggga aggcgcggct cgttcccgcc aggtggatcg aaccgaccgc gtttgaaccg     2460

gagtatgatc tccatctcaa caacggccgc atgctcgagc acttccacga ggggaatcta     2520

acctatcgcg tccacggcct caaggaaaag gtgccgacga cgtacctcga ggtgtcgcca     2580

gaactcgcca aggagcgggg catcgagacg ggggcgttgg ttcgcctcat ctcgccgtac     2640

ggcgagttga agcttcccgt cgtggtgacg gatcgagtca agggcaagca aatgtatttg     2700

ccgatgaaca cgtccaacga tgaagaggcc atcaacatcc tcacgtcgag cgagtcggac     2760

gagacgacgc acacgccggc gtacaaggag ctgcaggtgc ggatggaagt gattcggccg     2820

cgtggggaaa gcccgatgac acggttcaac ttccggatgc acaggccgaa tccgcaatcc     2880

ggcgtgcgcg tcgaacggaa gtggtcgcgg cgcggttacg tgccggtggc cgaggcggcg     2940

aaggaaaagg cgagggggtg a                                               2961


<210>   473
<211>   2961
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   473
atgagcgttg atttgaagcg aaccttcacg ctggacggat cgcccctgac ggcgaccgag       60

ggggagacca tcctgcaggc gatgttggcg gctggcctag actttcccca catctgttat      120

catcctgcgc ttggccccat cgagacctgc gacacgtgca tggtagaggt gaatggcgat      180

ctcgtccggg cgtgcgcgac cccggtcgtc gagggcatgt cggtccgcac caaatccgtg      240

gccgcgcggt acgcgcgcaa ggaggcgatg gatcgcatcc tgaaaaacca cgacctctac      300

tgcacggtct gcgacaacaa caacggcaac tgcgtggtgc acaacaccac gatggcgatg      360

gacatcgacc atcagtcgta cccgttccgc gagaagccgt acgaagtcga catgtcgcac      420

ccgttctacc ggtacgatcc gagccagtgc atcctctgcg ggcgatgcgt cgaggcgtgt      480

cagaacctgc aggtcagtga agtgctttcc atcgactggg atcgcgagat tccgcgcgtc      540

atctgggaca atgacgtccc catcaacgag tcgtcgtgcg tctcgtgcgg ccactgcgtg      600

accgtctgcc cctgcaatgc gctcatggag aagtcgatgc tcggcaaggc tggattcctc      660

acgggcatcg aaccggagcc gctgcagcgg atgatcgacg tgacgaaggc ggtggagccc      720

ggctaccgcg ccatctttgc catctccgag atcgagagcc acatgcggaa ttcccgcatc      780

aagcgcacga agaccgtgtg cacgtactgc ggcgtgggct gctcgtttga catctggacg      840

aaggaccggg acatcctgaa ggtcgaaccg cagatggagg cgccgaccaa ccagatctcc      900

acctgcgtca agggaaagtt cggctgggat tttgtgaata gcccggaccg cctcacgaag      960

cccctcatcc gcaagggcga cgcgtttcat gaggtgtcgt gggacgaggc cttggacttc     1020

gtcgcgaagc gcctgacgga aatccgccag caatacggcg acgatgccat cgcattgatc     1080

tcgtcctcga agtgcaccaa cgaggaaaac tacctgatgc aaaaactcgc ccgcgccgtt     1140

ctccacacga acaacatcga caactgttca cggtactgcc agtcgcccgc caccgagggt     1200

ctgcgccgga ccatgggtta cggcggcgac accggctcgc tccacgatct cgccatggcc     1260

gatctgctca tcatcattgg cgcgaacccg gccgagtccc accccgtctt ctcgacccgc     1320

atgcggcggg ccaagaagaa gtacggccag aagcacatcg tgatcgacct tcgcgaacac     1380

gatatggcgc accgcgccga cctgttcgtc cggccgaatc ctggaaccga tctggtgctc     1440

atctcggccg tgacgaggta catcatcgac cagggttggc acgacgccga cttcgtgcgc     1500

gatcgcgtcg acggttttga agatttcgtc cgctcgctcg agccgtatac gctcgagtac     1560

gccgagcgcg tgacgggcgt gccgcgcgac accgtgattc agatcgccac gatgatccat     1620

gaggccaagt ccacctgcat ctgttgggcg atgggcgtga cgcagcacaa ggggggcagc     1680

gagaccagca ccgccatctg caacctcctg ctcgtcacgg ggaacgtcgg gcgcccaggc     1740

accggggcct atccgctccg aggccacaac aacgtccaag gggcgggcga catgggctgc     1800

agcccggtgt acatgccggg ctacgagcgc gtcgatgatc cggccgtgcg agccaagtac     1860

gagacggcct gggtcgtgga gctgccgacg agcaaggggc tcgacaacca cgagatggtg     1920

gacgcgattc acgagggcaa acttcgggcc cttatcattc agggcgagga gatggcgctc     1980

gtcgactcga attcgcacta cgtccgcgag gcgtttgcga agctggatct gctcgtcgtg     2040

atcgacgtgt tcttcagcaa gactgctgag tacgccgacg tggtgctcgc cgcgagcccg     2100

agcctggaga aggagggcac gttcacgaac acggaacggc gcatccagcg cctgtaccag     2160

gtgttcgaac cgctcggcga atctcgcccg gactgggtca ttctgcgcga tctcgccaat     2220

cgcctgggcg ccaactggac gtacgcgcac ccgtccgaaa tcctcgagga aatggcgagc     2280

ttggcggcgc tgatgcaggg ggttcgctgg gatcgactgg agggctatcg cagcctgcag     2340

tggccggttc atcccgacgg gaccgatacg ccgctgctct acacgaacgg tttcccgttc     2400

ccgaatggga aggcgcggct cgttcccgcc aggtggatcg aaccgaccgc gtttgaaccg     2460

gagtatgatc tccatctcaa caacggccgc atgctcgagc acttccacga ggggaatcta     2520

acctatcgcg tccacggcct ccgtgaaaag gtgccgacga cgtacctcga ggtgtcgcca     2580

gaactcgcca aggagcgggg catcgagacg ggggcgttgg ttcgcctcat ctcgccgtac     2640

ggcgagttga agcttcccgt cgtggtgacg gatcgagtca agggcaagca aatgtatttg     2700

ccgatgaaca cgtccaacga tgaagaggcc atcaacatcc tcacgtcgag cgagtcggac     2760

gagacgacgc acacgccggc gtacaaggag ctgcaggtgc ggatggaagt gattcggccg     2820

cgtggggaaa gcccgatgac acggttcaac ttccggatgc acaggccgaa tccgcaatcc     2880

ggcgtgcgcg tcgaacggaa gtggtcgcgg cgcggttacg tgccggtggc cgaggcggcg     2940

aaggaaaagg cgagggggtg a                                               2961


<210>   474
<211>   2961
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   474
atgagcgttg atttgaagcg aaccttcacg ctggacggat cgcccctgac ggcgaccgag       60

ggggagacca tcctgcaggc gatgttggcg gctggcctag actttcccca catctgttat      120

catcctgcgc ttggccccat cgagacctgc gacacgtgca tggtagaggt gaatggcgat      180

ctcgtccggg cgtgcgcgac cccggtcgtc gagggcatgt cggtccgcac caaatccgtg      240

gccgcgcggt acgcgcgcaa ggaggcgatg gatcgcatcc tgaaaaacca cgacctctac      300

tgcacggtct gcgacaacaa caacggcaac tgcgtggtgc acaacaccac gatggcgatg      360

gacatcgacc atcagtcgta cccgttccgc gagaagccgt acgaagtcga catgtcgcac      420

ccgttctacc ggtacgatcc gagccagtgc atcctctgcg ggcgatgcgt cgaggcgtgt      480

cagaacctgc aggtcagtga agtgctttcc atcgactggg atcgcgagat tccgcgcgtc      540

atctgggaca atgacgtccc catcaacgag tcgtcgtgcg tctcgtgcgg ccactgcgtg      600

accgtctgcc cctgcaatgc gctcatggag aagtcgatgc tcggcaaggc tggattcctc      660

acgggcatcg aaccggagcc gctgcagcgg atgatcgacg tgacgaaggc ggtggagccc      720

ggctaccgcg ccatctttgc catctccgag atcgagagcc acatgcggaa ttcccgcatc      780

aagcgcacga agaccgtgtg cacgtactgc ggcgtgggct gctcgtttga catctggacg      840

aaggaccggg acatcctgaa ggtcgaaccg cagatggagg cgccgaccaa ccagatctcc      900

acctgcgtca agggaaagtt cggctgggat tttgtgaata gcccggaccg cctcacgaag      960

cccctcatcc gcaagggcga cgcgtttcat gaggtgtcgt gggacgaggc cttggacttc     1020

gtcgcgaagc gcctgacgga aatccgccag caatacggcg acgatgccat cgcattgatc     1080

tcgtcctcga agtgcaccaa cgaggaaaac tacctgatgc aaaaactcgc ccgcgccgtt     1140

ctccacacga acaacatcga caactgttca cggtactgcc agtcgcccgc caccgagggt     1200

ctgcgccgga ccatgggtta cggcggcgac accggctcgc tccacgatct cgccatggcc     1260

gatctgctca tcatcattgg cgcgaacccg gccgagtccc accccgtctt ctcgacccgc     1320

atgcggcggg ccaagaagaa gtacggccag aagcacatcg tgatcgacct tcgcgaacac     1380

gatatggcgc accgcgccga cctgttcgtc cggccgaatc ctggaaccga tctggtgctc     1440

atctcggccg tgacgaggta catcatcgac cagggttggc acgacgccga cttcgtgcgc     1500

gatcgcgtcg acggttttga agatttcgtc cgctcgctcg agccgtatac gctcgagtac     1560

gccgagcgcg tgacgggcgt gccgcgcgac accgtgattc agatcgccac gatgatccat     1620

gaggccaagt ccacctgcat ctgttgggcg atgggcgtga cgcagcacaa ggggggcagc     1680

gagaccagca ccgccatctg caacctcctg ctcgtcacgg ggaacgtcgg gcgcccaggc     1740

accggggcct atccgctccg aggccacaac aacgtccaag gggcgggcga catgggctgc     1800

agcccggtgt acatgccggg ctacgagcgc gtcgatgatc cggccgtgcg agccaagtac     1860

gagacggcct gggtcgtgga tctgccgacg agcaaggggc tcgacaacca cgagatggtg     1920

gacgcgattc acgagggcaa acttcgggcc cttatcattc agggcgagga gatggcgctc     1980

gtcgactcga attcgcacta cgtccgcgag gcgtttgcga agctggatct gctcgtcgtg     2040

atcgacgtgt tcttcagcaa gactgctgag tacgccgacg tggtgctcgc cgcgagcccg     2100

agcctggaga aggagggcac gttcacgaac acggaacggc gcatccagcg cctgtaccag     2160

gtgttcgaac cgctcggcga atctcgcccg gactgggtca ttctgcgcga tctcgccaat     2220

cgcctgggcg ccaactggac gtacgcgcac ccgtccgaaa tcctcgagga aatggcgagc     2280

ttggcggcgc tgatgcaggg ggttcgctgg gatcgactgg agggctatcg cagcctgcag     2340

tggccggttc atcccgacgg gaccgatacg ccgctgctct acacgaacgg tttcccgttc     2400

ccgaatggga aggcgcggct cgttcccgcc aggtggatcg aaccgaccgc gtttgaaccg     2460

gagtatgatc tccatctcaa caacggccgc atgctcgagc acttccacga ggggaatcta     2520

acctatcgcg tccacggcct caaggaaaag gtgccgacga cgtacctcga ggtgtcgcca     2580

gaactcgcca aggagcgggg catcgagacg ggggcgttgg ttcgcctcat ctcgccgtac     2640

ggcgagttga agcttcccgt cgtggtgacg gatcgagtca agggcaagca aatgtatttg     2700

ccgatgaaca cgtccaacga tgaagaggcc atcaacatcc tcacgtcgag cgagtcggac     2760

gagacgacgc acacgccggc gtacaaggag ctgcaggtgc ggatggaagt gattcggccg     2820

cgtggggaaa gcccgatgac acggttcaac ttccggatgc acaggccgaa tccgcaatcc     2880

ggcgtgcgcg tcgaacggaa gtggtcgcgg cgcggttacg tgccggtggc cgaggcggcg     2940

aaggaaaagg cgagggggtg a                                               2961


<210>   475
<211>   2961
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   475
atgagcgttg atttgaagcg aaccttcacg ctggacggat cgcccctgac ggcgaccgag       60

ggggagacca tcctgcaggc gatgttggcg gctggcctag actttcccca catctgttat      120

catcctgcgc ttggccccat cgagacctgc gacacgtgca tggtagaggt gaatggcgat      180

ctcgtccggg cgtgcgcgac cccggtcgtc gagggcatgt cggtccgcac caaatccgtg      240

gccgcgcggt acgcgcgcaa ggaggcgatg gatcgcatcc tgaaaaacca cgacctctac      300

tgcacggtct gcgacaacaa caacggcaac tgcgtggtgc acaacaccac gatggcgatg      360

gacatcgacc atcagtcgta cccgttccgc gagaagccgt acgaagtcga catgtcgcac      420

ccgttctacc ggtacgatcc gagccagtgc atcctctgcg ggcgatgcgt cgaggcgtgt      480

cagaacctgc aggtcagtga agtgctttcc atcgactggg atcgcgagat tccgcgcgtc      540

atctgggaca atgacgtccc catcaacgag tcgtcgtgcg tctcgtgcgg ccactgcgtg      600

accgtctgcc cctgcaatgc gctcatggag aagtcgatgc tcggcaaggc tggattcctc      660

acgggcatcg aaccggagcc gctgcagcgg atgatcgacg tgacgaaggc ggtggagccc      720

ggctaccgcg ccatctttgc catctccgag atcgagagcc acatgcggaa ttcccgcatc      780

aagcgcacga agaccgtgtg cacgtactgc ggcgtgggct gctcgtttga catctggacg      840

aaggaccggg acatcctgaa ggtcgaaccg cagatggagg cgccgaccaa ccagatctcc      900

acctgcgtca agggaaagtt cggctgggat tttgtgaata gcccggaccg cctcacgaag      960

cccctcatcc gcaagggcga cgcgtttcat gaggtgtcgt gggacgaggc cttggacttc     1020

gtcgcgaagc gcctgacgga aatccgccag caatacggcg acgatgccat cgcattgatc     1080

tcgtcctcga agtgcaccaa cgaggaaaac tacctgatgc aaaaactcgc ccgcgccgtt     1140

ctccacacga acaacatcga caactgttca cggtactgcc agtcgcccgc caccgagggt     1200

ctgcgccgga ccatgggtta cggcggcgac accggctcgc tccacgatct cgccatggcc     1260

gatctgctca tcatcattgg cgcgaacccg gccgagtccc accccgtctt ctcgacccgc     1320

atgcggcggg ccaagaagaa gtacggccag aagcacatcg tgatcgacct tcgcgaacac     1380

gatatggcgc accgcgccga cctgttcgtc cggccgaatc ctggaaccga tctggtgctc     1440

atctcggccg tgacgaggta catcatcgac cagggttggc acgacgccga cttcgtgcgc     1500

gatcgcgtcg acggttttga agatttcgtc cgctcgctcg agccgtatac gctcgagtac     1560

gccgagcgcg tgacgggcgt gccgcgcgac accgtgattc agatcgccac gatgatccat     1620

gaggccaagt ccacctgcat ctgttgggcg atgggcgtga cgcagcacaa ggggggcagc     1680

gagaccagca ccgccatctg caacctcctg ctcgtcacgg ggaacgtcgg gcgcccaggc     1740

accggggcct atccgctccg aggccacaac aacgtccaag gggcgggcga catgggctgc     1800

agcccggtgt acatgccggg ctacgagcgc gtcgatgatc cggccgtgcg agccaagtac     1860

gagacggcct gggtcgtgga gctgccgacg agcaaggggc tcgacaacca cgagatggtg     1920

gacgcgattc acgagggcaa acttcgggcc cttatcattc agggcgagga gatggcgctc     1980

gtcgactcga attcgcacta cgtccgcgag gcgtttgcga agctggatct gctcgtcgtg     2040

atcgacgtgt tcttcagcaa gactgctgag tacgccgacg tggtgctcgc cgcgagcccg     2100

agcctggaga aggagggcac gttcacgaac acggaacggc gcatccagcg cctgtaccag     2160

gtgttcgaac cgctcggcga atctcgcccg gactgggtca ttctgcgcga tctcgccaat     2220

aaactgggcg ccaactggac gtacgcgcac ccgtccgaaa tcctcgagga aatggcgagc     2280

ttggcggcgc tgatgcaggg ggttcgctgg gatcgactgg agggctatcg cagcctgcag     2340

tggccggttc atcccgacgg gaccgatacg ccgctgctct acacgaacgg tttcccgttc     2400

ccgaatggga aggcgcggct cgttcccgcc aggtggatcg aaccgaccgc gtttgaaccg     2460

gagtatgatc tccatctcaa caacggccgc atgctcgagc acttccacga ggggaatcta     2520

acctatcgcg tccacggcct caaggaaaag gtgccgacga cgtacctcga ggtgtcgcca     2580

gaactcgcca aggagcgggg catcgagacg ggggcgttgg ttcgcctcat ctcgccgtac     2640

ggcgagttga agcttcccgt cgtggtgacg gatcgagtca agggcaagca aatgtatttg     2700

ccgatgaaca cgtccaacga tgaagaggcc atcaacatcc tcacgtcgag cgagtcggac     2760

gagacgacgc acacgccggc gtacaaggag ctgcaggtgc ggatggaagt gattcggccg     2820

cgtggggaaa gcccgatgac acggttcaac ttccggatgc acaggccgaa tccgcaatcc     2880

ggcgtgcgcg tcgaacggaa gtggtcgcgg cgcggttacg tgccggtggc cgaggcggcg     2940

aaggaaaagg cgagggggtg a                                               2961


<210>   476
<211>   2961
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   476
atgagcgttg atttgaagcg aaccttcacg ctggacggat cgcccctgac ggcgaccgag       60

ggggagacca tcctgcaggc gatgttggcg gctggcctag actttcccca catctgttat      120

catcctgcgc ttggccccat cgagacctgc gacacgtgca tggtagaggt gaatggcgat      180

ctcgtccggg cgtgcgcgac cccggtcgtc gagggcatgt cggtccgcac caaatccgtg      240

gccgcgcggt acgcgcgcaa ggaggcgatg gatcgcatcc tgaaaaacca cgacctctac      300

tgcacggtct gcgacaacaa caacggcaac tgcgtggtgc acaacaccac gatggcgatg      360

gacatcgacc atcagtcgta cccgttccgc gagaagccgt acgaagtcga catgtcgcac      420

ccgttctacc ggtacgatcc gagccagtgc atcctctgcg ggcgatgcgt cgaggcgtgt      480

cagaacctgc aggtcagtga agtgctttcc atcgactggg atcgcgagat tccgcgcgtc      540

atctgggaca atgacgtccc catcaacgag tcgtcgtgcg tctcgtgcgg ccactgcgtg      600

accgtctgcc cctgcaatgc gctcatggag aagtcgatgc tcggcaaggc tggattcctc      660

acgggcatcg aaccggagcc gctgcagcgg atgatcgacg tgacgaaggc ggtggagccc      720

ggctaccgcg ccatctttgc catctccgag atcgagagcc acatgcggaa ttcccgcatc      780

aagcgcacga agaccgtgtg cacgtactgc ggcgtgggct gctcgtttga catctggacg      840

aaggaccggg acatcctgaa ggtcgaaccg cagatggagg cgccgaccaa ccagatctcc      900

acctgcgtca agggaaagtt cggctgggat tttgtgaata gcccggaccg cctcacgaag      960

cccctcatcc gcaagggcga cgcgtttcat gaggtgtcgt gggacgaggc cttggacttc     1020

gtcgcgaagc gcctgacgga aatccgccag caatacggcg acgatgccat cgcattgatc     1080

tcgtcctcga agtgcaccaa cgaggaaaac tacctgatgc aaaaactcgc ccgcgccgtt     1140

ctccacacga acaacatcga caactgttca cggtactgcc agtcgcccgc caccgagggt     1200

ctgcgccgga ccatgggtta cggcggcgac accggctcgc tccacgatct cgccatggcc     1260

gatctgctca tcatcattgg cgcgaacccg gccgagtccc accccgtctt ctcgacccgc     1320

atgcggcggg ccaagaagaa gtacggccag aagcacatcg tgatcgacct tcgcgaacac     1380

gatatggcgc accgcgccga cctgttcgtc cggccgaatc ctggaaccga tctggtgctc     1440

atctcggccg tgacgaggta catcatcgac cagggttggc acgacgccga cttcgtgcgc     1500

gatcgcgtcg acggttttga agatttcgtc cgctcgctcg agccgtatac gctcgagtac     1560

gccgagcgcg tgacgggcgt gccgcgcgac accgtgattc agatcgccac gatgatccat     1620

gaggccaagt ccacctgcat ctgttgggcg atgggcgtga cgcagcacaa ggggggcagc     1680

gagaccagca ccgccatctg caacctcctg ctcgtcacgg ggaacgtcgg gcgcccaggc     1740

accggggcct atccgctccg aggccacaac aacgtccaag gggcgggcga catgggctgc     1800

agcccggtgt acatgccggg ctacgagcgc gtcgatgatc cggccgtgcg agccaagtac     1860

gagacggcct gggtcgtgga gctgccgacg agcaaggggc tcgacaacca cgagatggtg     1920

gacgcgattc acgagggcaa acttcgggcc cttatcattc agggcgagga gatggcgctc     1980

gtcgactcga attcgcacta cgtccgcgag gcgtttgcga agctggatct gctcgtcgtg     2040

atcgacgtgt tcttcagcaa gactgctgag tacgccgacg tggtgctcgc cgcgagcccg     2100

agcctggaga aggagggcac gttcacgaac acggaacggc gcatccagcg cctgtaccag     2160

gtgttcgaac cgctcggcga atctcgcccg gactgggtca ttctgcgcga tctcgccaat     2220

cgcctgggcg ccaactggac gtacgcgcac ccgtccgaaa tcctcgagga aatggcgagc     2280

ttggcggcgc tgatgcaggg ggttcgctgg gatcgactgg agggctatcg cagcctgcag     2340

tggccggttc atcccgacgg gaccgatacg ccgctgctct acacgaacgg tttcccgttc     2400

ccgaatggga aggcgcggct cgttcccgcc aggtggatcg aaccgaccgc gtttgaaccg     2460

gagtatgatc tccatctcaa caacggccgc atgctcgagc acttccacga ggggaatcta     2520

acctatcgcg tccacggcct caaggaaaag gtgccgacga cgtacctcga ggtgtcgcca     2580

gaactcgcca aggagcgggg catcgagacg ggggcgttgg ttcgcctcat ctcgccgtac     2640

ggcgagttga agcttcccgt cgtggtgacg gatcgagtca agggcaagca aatgtatttg     2700

ccgatgaaca cgtccaacga tgaagaggcc atcaacatcc tcacgtcgag cgagtcggac     2760

gagacgacgc acacgccggc gtacaaggag ctgcaggtgc ggatggaagt gattcggccg     2820

cgtggggaaa gcccgatgac acggttcaac ttccggatgc acaggccgaa tccgcaatcc     2880

ggcgtgcgcg tcgaacggaa gtggtcgcgg cgcggttacg tgccggtggc cgaggcggcg     2940

aaggaaaagg cgaaagggtg a                                               2961


<210>   477
<211>   280
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   477
Met Asn Gly Val Ser Arg Phe Gly Gly Ala Glu Thr Arg Arg Arg Phe 
                5                   10                  15      

Val Leu Arg Tyr Arg Ser Gly Glu Tyr Arg Gln Glu Glu Asp Val Ile 
            20                  25                  30          

Ala Thr Glu Phe Ala Leu Thr Leu Phe Val Asn Gly Glu Glu Phe Ser 
        35                  40                  45              

Thr Leu Val Cys Thr Pro Thr Tyr Ala Glu Asp Leu Val Tyr Gly Phe 
    50                  55                  60                  

Leu Ala Ser Glu Gly Val Ile Arg Asp Val Asp Asp Val Glu Ser Ile 
65                  70                  75                  80  

Arg Val Ser Leu Trp Thr Gly Thr Ala Arg Val Gln Thr Lys Ser Gly 
                85                  90                  95      

Ala Val Leu Ser Pro Ala Leu Tyr Asn Lys Arg Tyr Ile Gly Ser Cys 
            100                 105                 110         

Cys Gly Lys Gly Arg Gln Ser Phe Tyr Phe Gln Ser Asp Ala Leu Thr 
        115                 120                 125             

Ala Arg Pro Val Glu Asp Pro Val Ser Leu Ser Ala Asp Asp Val Phe 
    130                 135                 140                 

Arg Ala Met Asp Leu Leu Asp Ala Ser Ser Gly Leu Phe Glu Glu Thr 
145                 150                 155                 160 

Gly Gly Val His Val Ala Ala Leu Val Arg Glu Gly Gln Leu Val Leu 
                165                 170                 175     

Ala Arg Ala Asp Ile Gly Arg His Asn Ala Leu Asp Lys Ile Tyr Gly 
            180                 185                 190         

His Cys Leu Arg Ala Gly Glu Arg Leu Ser Gly Thr Ala Val Ala Phe 
        195                 200                 205             

Ser Gly Arg Ile Ser Ser Glu Val Leu Leu Lys Val Ala Lys Ile Gly 
    210                 215                 220                 

Val Gly Val Val Ile Ala Arg Gly Ala Pro Thr Leu Leu Ala Val Asp 
225                 230                 235                 240 

Leu Ala Glu Glu Leu Asn Ile Thr Ala Ile Gly Phe Val Arg Gly Arg 
                245                 250                 255     

Ala Phe Asn Val Tyr Ser His Pro Trp Arg Leu Ala Asp Ala Lys Lys 
            260                 265                 270         

Ala Gln Gly Ala Ile Glu Gly Ala 
        275                 280 

<210>   478
<211>   843
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   478
gtgaatggcg tgtcgcgctt tgggggagcg gaaacgcgga ggcgcttcgt gctccgatat       60

cggtccgggg agtatcggca ggaggaggac gtgatcgcga cggaattcgc actcacgctg      120

ttcgtcaacg gcgaggagtt ctcgacgctc gtgtgcacgc cgacctacgc ggaggacctg      180

gtgtatggct ttctcgcttc ggaaggcgtc atccgcgacg tggacgacgt cgagtcgatt      240

cgggtgagcc tgtggacggg aacggcccgt gtacagacga agtccggcgc ggtgctttcc      300

ccggcgcttt acaacaaacg gtacatcggg tcttgttgcg ggaaggggcg acagagcttc      360

tatttccaga gcgacgccct gaccgcgcga cccgtcgagg atccggtgtc gctctcggcg      420

gacgacgtgt ttcgggcgat ggatctcctc gacgcgtcgt ccgggctgtt cgaggaaacg      480

ggcggtgtgc acgtggcggc gctggtgcgt gaaggacagc tcgtcttggc gagggccgac      540

attggccgcc acaacgcgct cgacaagatc tacggccact gcctccgggc cggcgagagg      600

ttgtccggca ccgccgtggc gttcagcggc cggatctcgt ccgaggtgtt gctcaaggtc      660

gccaagatcg gtgtgggcgt cgtgatcgcc cgaggagctc cgacgctgct cgccgtcgat      720

ctcgccgagg aactgaacat cacggccatc ggttttgtgc gcggccgggc cttcaacgtg      780

tacagtcatc cgtggcgctt ggcggacgcc aagaaggcgc agggcgccat cgaaggggca      840

tga                                                                    843


<210>   479
<211>   258
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   479
Gly Phe Ala Ala Lys Arg Arg Pro Ile Ala Lys Tyr Arg Asn Gly Arg 
                5                   10                  15      

Phe Val Glu Glu Glu Asp Glu Ile Ala Leu Glu Phe Pro Leu Thr Ile 
            20                  25                  30          

Thr Val Asn Gly Glu Glu Phe Ala Thr Ile Val Cys Thr Pro Ala His 
        35                  40                  45              

Leu Asp Glu Leu Val Ile Gly Phe Leu Ala Ser Glu Gly Ala Ile Arg 
    50                  55                  60                  

Thr Cys Ser Asp Ile Lys Gly Met Thr Ile Asp Gly Glu Arg Gly Phe 
65                  70                  75                  80  

Ala Tyr Val Glu Leu Ala Ala Gly Gly Leu Pro Ala Lys Gln Phe Tyr 
                85                  90                  95      

Ala Lys Arg Phe Ile Gly Ser Cys Cys Gly Lys Ser Arg Gln Phe Tyr 
            100                 105                 110         

Phe Tyr Asn Asp Met Lys Thr Ala Lys Thr Ile Val Gly Gly Ile Thr 
        115                 120                 125             

Val Lys Ala Asp Asp Cys Ile Arg Leu Met Lys Ala Leu His Glu Arg 
    130                 135                 140                 

Ser Thr Asp Phe Ala Ala Thr Gly Gly Leu His Asn Ala Ala Leu Ala 
145                 150                 155                 160 

Thr Pro Asp Glu Met Val Val Ile Arg Ser Asp Ile Gly Arg His Asn 
                165                 170                 175     

Ala Leu Asp Lys Leu Tyr Gly Tyr Cys Leu Arg His Gln Val Ala Met 
            180                 185                 190         

Lys Asp Lys Leu Ile Val Phe Ser Gly Arg Val Ser Ser Glu Val Leu 
        195                 200                 205             

Leu Lys Ala Ala Lys Met Gly Val Ser Val Leu Leu Ser Lys Ser Ala 
    210                 215                 220                 

Pro Thr Thr Leu Ala Leu Asp Leu Ala Asp Glu Leu Gly Ile Thr Val 
225                 230                 235                 240 

Val Gly Phe Leu Arg Gly Gln Ala Phe Asn Val Tyr Thr His Glu Ser 
                245                 250                 255     

Arg Ile 
        

<210>   480
<211>   258
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   480
Gly Phe Val Ala Lys Arg Arg Tyr Ile Val Lys Tyr Arg Asn Gly Gln 
                5                   10                  15      

Leu Ala Glu Lys Glu Asp Glu Ile Ala Leu Glu Phe Pro Leu Thr Val 
            20                  25                  30          

Val Val Asn Gly Gln Glu Phe Ala Thr Ile Val Cys Thr Pro Gly His 
        35                  40                  45              

Ile Asp Glu Leu Val Ile Gly Phe Leu Ala Ser Glu Gly Val Ile Arg 
    50                  55                  60                  

Val Ile Asp Asp Ile Lys Ala Met Thr Ile Asp Gly Glu Arg Gly Phe 
65                  70                  75                  80  

Val Tyr Val Glu Leu Thr Ser Asp Glu Leu Pro Ala Lys Gln Phe Tyr 
                85                  90                  95      

Ala Lys Arg Phe Ile Gly Ser Cys Cys Gly Lys Ser Arg Gln Phe Tyr 
            100                 105                 110         

Phe Tyr Asn Asp Ala Lys Thr Ala Lys Thr Ile Val Gly Gly Ile Thr 
        115                 120                 125             

Val Lys Ala Asp Asp Cys Val Cys Leu Met Lys Thr Leu His Glu Gln 
    130                 135                 140                 

Ser Ile Asp Phe Ala Ala Thr Gly Gly Leu His Asn Ala Ala Leu Ala 
145                 150                 155                 160 

Thr Pro Asp Arg Ile Val Val Ile Arg Ser Asp Ile Gly Arg His Asn 
                165                 170                 175     

Ala Leu Asp Lys Leu Tyr Gly Tyr Cys Leu Arg His Gln Val Ala Met 
            180                 185                 190         

Lys Asp Lys Leu Ile Val Phe Ser Gly Arg Val Ser Ser Glu Val Leu 
        195                 200                 205             

Leu Lys Ala Ala Lys Met Gly Ile Ser Ile Leu Leu Ser Lys Ser Ala 
    210                 215                 220                 

Pro Thr Thr Leu Ala Leu Asp Leu Ala Glu Glu Leu Gly Ile Thr Val 
225                 230                 235                 240 

Val Gly Phe Leu Arg Gly Gln Asp Phe Asn Val Tyr Thr His Glu Lys 
                245                 250                 255     

Arg Ile 
        

<210>   481
<211>   252
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   481
Ile Val Arg Tyr Gln Ser Gly Thr Phe Ser Lys Gln Leu Asp Glu Ile 
                5                   10                  15      

Val Thr Glu Ser Pro Ile Thr Ile Lys Leu Asn Gly Glu Glu Tyr Val 
            20                  25                  30          

Thr Val Val Cys Thr Pro Asn Tyr Ile Glu Asp Met Val Ile Gly Phe 
        35                  40                  45              

Leu Ile Ser Glu Gly Ile Ile Ser Ser Tyr Asn Asp Val Glu Glu Leu 
    50                  55                  60                  

Trp Val Gln Lys Asp Asn Gly Ile Val His Val Lys Ser Ser Lys Val 
65                  70                  75                  80  

Asn Pro Leu Tyr Gln Thr Leu Tyr Asn Lys Arg Tyr Val Thr Ser Cys 
                85                  90                  95      

Cys Gly Lys Gly Arg Gln Gly Phe Ile Phe Val Asn Asp Ala Ala Lys 
            100                 105                 110         

Ala Lys Asp Leu His Asp Ile His Val Lys Ile Thr Pro Glu Glu Cys 
        115                 120                 125             

Phe Tyr Leu Met Asn Thr Leu Gln Gln Ser Ser Thr Thr Phe Arg Gln 
    130                 135                 140                 

Thr Gly Gly Val His Asn Thr Ala Leu Cys Asp Arg Asn Lys Ile Leu 
145                 150                 155                 160 

Leu Ser Arg Met Asp Ile Gly Arg His Asn Ala Leu Asp Lys Ile Tyr 
                165                 170                 175     

Gly His Cys Leu Arg Asn Asp Ile Ser Val Lys Gly Lys Ile Ile Ala 
            180                 185                 190         

Phe Ser Gly Arg Ile Ser Ser Glu Ile Leu Leu Lys Val Ser Lys Ile 
        195                 200                 205             

Gly Cys Glu Ile Val Leu Ser Lys Ser Ala Pro Thr Lys Leu Ala Leu 
    210                 215                 220                 

Gln Leu Ala His Asp Leu Gly Ile Thr Val Val Gly Phe Ile Arg Asn 
225                 230                 235                 240 

Glu Ser Cys Asn Ile Tyr Thr His Pro His Arg Ile 
                245                 250         

<210>   482
<211>   252
<212>   PRT
<213>   Bacillus thuringiensis serovar israelensis ATCC 35646

<400>   482
Ile Val Arg Tyr Gln Ser Gly Thr Phe Ser Lys Gln Leu Asp Glu Ile 
                5                   10                  15      

Val Thr Glu Ser Pro Ile Thr Ile Lys Leu Asn Gly Glu Glu Tyr Val 
            20                  25                  30          

Thr Val Val Cys Thr Pro Asn Tyr Ile Glu Asp Met Val Ile Gly Phe 
        35                  40                  45              

Leu Ile Ser Glu Gly Ile Ile Ser Ser Tyr Lys Asp Val Glu Glu Leu 
    50                  55                  60                  

Trp Val Gln Lys Asp Asn Gly Ile Val His Val Lys Ser Ser Lys Val 
65                  70                  75                  80  

Asn Pro Leu Tyr Gln Thr Leu Tyr Asn Lys Arg Tyr Ile Thr Ser Cys 
                85                  90                  95      

Cys Gly Lys Gly Arg Gln Gly Phe Ile Phe Val Asn Asp Ala Ala Lys 
            100                 105                 110         

Ala Lys Asp Leu His Asp Ile His Val Lys Ile Thr Pro Glu Glu Cys 
        115                 120                 125             

Phe His Leu Met Asn Thr Leu Gln Gln Ser Ser Thr Thr Phe Arg Gln 
    130                 135                 140                 

Thr Gly Gly Val His Asn Thr Ala Leu Cys Asp Arg Asn Asn Ile Leu 
145                 150                 155                 160 

Leu Ser Arg Met Asp Ile Gly Arg His Asn Ala Leu Asp Lys Ile Tyr 
                165                 170                 175     

Gly His Cys Leu Arg Asn Asp Ile Ser Ile Lys Gly Lys Ile Ile Ala 
            180                 185                 190         

Phe Ser Gly Arg Ile Ser Ser Glu Ile Leu Leu Lys Val Ser Lys Ile 
        195                 200                 205             

Gly Cys Glu Ile Val Leu Ser Lys Ser Ala Pro Thr Lys Leu Ala Leu 
    210                 215                 220                 

Gln Leu Ala His Asp Leu Gly Ile Thr Val Val Gly Phe Ile Arg Asn 
225                 230                 235                 240 

Glu Ser Cys Asn Ile Tyr Thr His Pro Lys Arg Ile 
                245                 250         

<210>   483
<211>   257
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   483
Thr Ala Val Arg Asp Val Trp Arg Tyr Glu Gln Gly Glu Ile Ser Lys 
                5                   10                  15      

Val Glu Asp Arg Met Val Thr Glu Phe Pro Leu Thr Val Ile Leu Asn 
            20                  25                  30          

Gly Ser Glu Phe Val Thr Leu Val Cys Thr Pro Glu His Ile Glu Glu 
        35                  40                  45              

Leu Val Ile Gly Phe Leu Ala Ser Glu Gly Val Ile Arg Phe Gln Lys 
    50                  55                  60                  

Glu Ile Lys Arg Phe Thr Ile Asp Glu Ser Leu Gly Phe Val Tyr Val 
65                  70                  75                  80  

Asp Leu Val His Pro Glu Thr Leu Asp Gln Lys Asp Tyr Thr Lys Arg 
                85                  90                  95      

Val Ile Gly Ser Cys Cys Gly Lys Gly Arg His Phe Tyr Phe Gln Gln 
            100                 105                 110         

Asp Val Lys Thr Ala Lys Thr Ala Val Ser Gln Ile Lys Ile Ser Pro 
        115                 120                 125             

Glu Ala Cys Leu Ala Leu Met Lys Asp Met Gln Gln Gly Ser Gly Thr 
    130                 135                 140                 

Phe Gln Asp Thr Gly Gly Val His Asn Ala Ala Leu Cys Asp Thr Glu 
145                 150                 155                 160 

Lys Leu Leu Leu Met Arg Thr Asp Ile Gly Arg His Asn Ala Leu Asp 
                165                 170                 175     

Lys Leu Tyr Gly His Cys Leu Leu Asn Gly Met Ser Val Arg Asp Lys 
            180                 185                 190         

Leu Ile Val Phe Ser Gly Arg Ile Ser Ser Glu Val Leu Leu Lys Ala 
        195                 200                 205             

Ala Lys Ile Gly Val Ser Ile Val Ile Ser Lys Ser Ala Pro Thr Glu 
    210                 215                 220                 

Leu Ala Ile Gln Met Ala Glu Glu Leu Asn Ile Thr Ala Ile Gly Phe 
225                 230                 235                 240 

Val Arg Asn Gly Ser Phe Asn Val Tyr Thr His Pro Glu Arg Ile Arg 
                245                 250                 255     

Glu 
    

<210>   484
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   484
Met Asn Gly Val Ser Arg Phe Gly Gly Ala Glu Thr Arg Arg Arg Phe 
                5                   10                  15      

Val Leu Arg Tyr Arg Ser Gly Glu Tyr Lys Gln Glu Glu Asp Val Ile 
            20                  25                  30          

Ala Thr Glu Phe Ala Leu Thr Leu Phe Val Asn Gly Glu Glu Phe Ser 
        35                  40                  45              

Thr Leu Val Cys Thr Pro Thr Tyr Ala Glu Asp Leu Val Tyr Gly Phe 
    50                  55                  60                  

Leu Ala Ser Glu Gly Val Ile Arg Asp Val Asp Asp Val Glu Ser Ile 
65                  70                  75                  80  

Arg Val Ser Leu Trp Thr Gly Thr Ala Arg Val Gln Thr Lys Ser Gly 
                85                  90                  95      

Ala Val Leu Ser Pro Ala Leu Tyr Asn Lys Arg Tyr Ile Gly Ser Cys 
            100                 105                 110         

Cys Gly Lys Gly Arg Gln Ser Phe Tyr Phe Gln Ser Asp Ala Leu Thr 
        115                 120                 125             

Ala Arg Pro Val Glu Asp Pro Val Ser Leu Ser Ala Asp Asp Val Phe 
    130                 135                 140                 

Arg Ala Met Asp Leu Leu Asp Ala Ser Ser Gly Leu Phe Glu Glu Thr 
145                 150                 155                 160 

Gly Gly Val His Val Ala Ala Leu Val Arg Glu Gly Gln Leu Val Leu 
                165                 170                 175     

Ala Arg Ala Asp Ile Gly Arg His Asn Ala Leu Asp Lys Ile Tyr Gly 
            180                 185                 190         

His Cys Leu Arg Ala Gly Glu Arg Leu Ser Gly Thr Ala Val Ala Phe 
        195                 200                 205             

Ser Gly Arg Ile Ser Ser Glu Val Leu Leu Lys Val Ala Lys Ile Gly 
    210                 215                 220                 

Val Gly Val Val Ile Ala Arg Gly Ala Pro Thr Leu Leu Ala Val Asp 
225                 230                 235                 240 

Leu Ala Glu Glu Leu Asn Ile Thr Ala Ile Gly Phe Val Arg Gly Arg 
                245                 250                 255     

Ala Phe Asn Val Tyr Ser His Pro Trp Arg Leu Ala Asp Ala Lys Lys 
            260                 265                 270         

Ala Gln Gly Ala Ile Glu Gly Ala 
        275                 280 

<210>   485
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   485
Met Asn Gly Val Ser Arg Phe Gly Gly Ala Glu Thr Arg Lys Arg Phe 
                5                   10                  15      

Val Leu Arg Tyr Arg Ser Gly Glu Tyr Arg Gln Glu Glu Asp Val Ile 
            20                  25                  30          

Ala Thr Glu Phe Ala Leu Thr Leu Phe Val Asn Gly Glu Glu Phe Ser 
        35                  40                  45              

Thr Leu Val Cys Thr Pro Thr Tyr Ala Glu Asp Leu Val Tyr Gly Phe 
    50                  55                  60                  

Leu Ala Ser Glu Gly Val Ile Arg Asp Val Asp Asp Val Glu Ser Ile 
65                  70                  75                  80  

Arg Val Ser Leu Trp Thr Gly Thr Ala Arg Val Gln Thr Lys Ser Gly 
                85                  90                  95      

Ala Val Leu Ser Pro Ala Leu Tyr Asn Lys Arg Tyr Ile Gly Ser Cys 
            100                 105                 110         

Cys Gly Lys Gly Arg Gln Ser Phe Tyr Phe Gln Ser Asp Ala Leu Thr 
        115                 120                 125             

Ala Arg Pro Val Glu Asp Pro Val Ser Leu Ser Ala Asp Asp Val Phe 
    130                 135                 140                 

Arg Ala Met Asp Leu Leu Asp Ala Ser Ser Gly Leu Phe Glu Glu Thr 
145                 150                 155                 160 

Gly Gly Val His Val Ala Ala Leu Val Arg Glu Gly Gln Leu Val Leu 
                165                 170                 175     

Ala Arg Ala Asp Ile Gly Arg His Asn Ala Leu Asp Lys Ile Tyr Gly 
            180                 185                 190         

His Cys Leu Arg Ala Gly Glu Arg Leu Ser Gly Thr Ala Val Ala Phe 
        195                 200                 205             

Ser Gly Arg Ile Ser Ser Glu Val Leu Leu Lys Val Ala Lys Ile Gly 
    210                 215                 220                 

Val Gly Val Val Ile Ala Arg Gly Ala Pro Thr Leu Leu Ala Val Asp 
225                 230                 235                 240 

Leu Ala Glu Glu Leu Asn Ile Thr Ala Ile Gly Phe Val Arg Gly Arg 
                245                 250                 255     

Ala Phe Asn Val Tyr Ser His Pro Trp Arg Leu Ala Asp Ala Lys Lys 
            260                 265                 270         

Ala Gln Gly Ala Ile Glu Gly Ala 
        275                 280 

<210>   486
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   486
Met Asn Gly Val Ser Arg Phe Gly Gly Ala Glu Thr Arg Arg Arg Phe 
                5                   10                  15      

Val Leu Arg Tyr Arg Ser Gly Glu Tyr Arg Gln Glu Glu Asp Val Ile 
            20                  25                  30          

Ala Thr Glu Phe Ala Leu Thr Leu Phe Val Asn Gly Glu Glu Phe Ser 
        35                  40                  45              

Thr Leu Val Cys Thr Pro Thr Tyr Ala Glu Asp Leu Val Tyr Gly Phe 
    50                  55                  60                  

Leu Ala Ser Glu Gly Val Ile Arg Asp Val Asp Asp Val Glu Ser Ile 
65                  70                  75                  80  

Arg Val Ser Leu Trp Thr Gly Thr Ala Arg Val Gln Thr Lys Ser Gly 
                85                  90                  95      

Ala Val Leu Ser Pro Ala Leu Tyr Asn Lys Arg Tyr Ile Gly Ser Cys 
            100                 105                 110         

Cys Gly Lys Gly Arg Gln Ser Phe Tyr Phe Asn Ser Asp Ala Leu Thr 
        115                 120                 125             

Ala Arg Pro Val Glu Asp Pro Val Ser Leu Ser Ala Asp Asp Val Phe 
    130                 135                 140                 

Arg Ala Met Asp Leu Leu Asp Ala Ser Ser Gly Leu Phe Glu Glu Thr 
145                 150                 155                 160 

Gly Gly Val His Val Ala Ala Leu Val Arg Glu Gly Gln Leu Val Leu 
                165                 170                 175     

Ala Arg Ala Asp Ile Gly Arg His Asn Ala Leu Asp Lys Ile Tyr Gly 
            180                 185                 190         

His Cys Leu Arg Ala Gly Glu Arg Leu Ser Gly Thr Ala Val Ala Phe 
        195                 200                 205             

Ser Gly Arg Ile Ser Ser Glu Val Leu Leu Lys Val Ala Lys Ile Gly 
    210                 215                 220                 

Val Gly Val Val Ile Ala Arg Gly Ala Pro Thr Leu Leu Ala Val Asp 
225                 230                 235                 240 

Leu Ala Glu Glu Leu Asn Ile Thr Ala Ile Gly Phe Val Arg Gly Arg 
                245                 250                 255     

Ala Phe Asn Val Tyr Ser His Pro Trp Arg Leu Ala Asp Ala Lys Lys 
            260                 265                 270         

Ala Gln Gly Ala Ile Glu Gly Ala 
        275                 280 

<210>   487
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   487
Met Asn Gly Val Ser Arg Phe Gly Gly Ala Glu Thr Arg Arg Arg Phe 
                5                   10                  15      

Val Leu Arg Tyr Arg Ser Gly Glu Tyr Arg Gln Glu Glu Asp Val Ile 
            20                  25                  30          

Ala Thr Glu Phe Ala Leu Thr Leu Phe Val Asn Gly Glu Glu Phe Ser 
        35                  40                  45              

Thr Leu Val Cys Thr Pro Thr Tyr Ala Glu Asp Leu Val Tyr Gly Phe 
    50                  55                  60                  

Leu Ala Ser Glu Gly Val Ile Arg Asp Val Asp Asp Val Glu Ser Ile 
65                  70                  75                  80  

Arg Val Ser Leu Trp Thr Gly Thr Ala Arg Val Gln Thr Lys Ser Gly 
                85                  90                  95      

Ala Val Leu Ser Pro Ala Leu Tyr Asn Lys Arg Tyr Ile Gly Ser Cys 
            100                 105                 110         

Cys Gly Lys Gly Arg Gln Ser Phe Tyr Phe Gln Ser Asp Ala Leu Thr 
        115                 120                 125             

Ala Arg Pro Val Glu Asp Pro Val Ser Leu Ser Ala Asp Asp Val Phe 
    130                 135                 140                 

Arg Ala Met Asp Leu Leu Asp Ala Ser Ser Gly Leu Phe Glu Glu Thr 
145                 150                 155                 160 

Gly Gly Val His Val Ala Ala Leu Val Arg Glu Gly Gln Leu Val Leu 
                165                 170                 175     

Ala Arg Ala Asp Ile Gly Arg His Asn Ala Leu Asp Lys Ile Tyr Gly 
            180                 185                 190         

His Cys Leu Arg Ala Gly Glu Lys Leu Ser Gly Thr Ala Val Ala Phe 
        195                 200                 205             

Ser Gly Arg Ile Ser Ser Glu Val Leu Leu Lys Val Ala Lys Ile Gly 
    210                 215                 220                 

Val Gly Val Val Ile Ala Arg Gly Ala Pro Thr Leu Leu Ala Val Asp 
225                 230                 235                 240 

Leu Ala Glu Glu Leu Asn Ile Thr Ala Ile Gly Phe Val Arg Gly Arg 
                245                 250                 255     

Ala Phe Asn Val Tyr Ser His Pro Trp Arg Leu Ala Asp Ala Lys Lys 
            260                 265                 270         

Ala Gln Gly Ala Ile Glu Gly Ala 
        275                 280 

<210>   488
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   488
Met Asn Gly Val Ser Arg Phe Gly Gly Ala Glu Thr Arg Arg Arg Phe 
                5                   10                  15      

Val Leu Arg Tyr Arg Ser Gly Glu Tyr Arg Gln Glu Glu Asp Val Ile 
            20                  25                  30          

Ala Thr Glu Phe Ala Leu Thr Leu Phe Val Asn Gly Glu Glu Phe Ser 
        35                  40                  45              

Thr Leu Val Cys Thr Pro Thr Tyr Ala Glu Asp Leu Val Tyr Gly Phe 
    50                  55                  60                  

Leu Ala Ser Glu Gly Val Ile Arg Asp Val Asp Asp Val Glu Ser Ile 
65                  70                  75                  80  

Arg Val Ser Leu Trp Thr Gly Thr Ala Arg Val Gln Thr Lys Ser Gly 
                85                  90                  95      

Ala Val Leu Ser Pro Ala Leu Tyr Gln Lys Arg Tyr Ile Gly Ser Cys 
            100                 105                 110         

Cys Gly Lys Gly Arg Gln Ser Phe Tyr Phe Gln Ser Asp Ala Leu Thr 
        115                 120                 125             

Ala Arg Pro Val Glu Asp Pro Val Ser Leu Ser Ala Asp Asp Val Phe 
    130                 135                 140                 

Arg Ala Met Asp Leu Leu Asp Ala Ser Ser Gly Leu Phe Glu Glu Thr 
145                 150                 155                 160 

Gly Gly Val His Val Ala Ala Leu Val Arg Glu Gly Gln Leu Val Leu 
                165                 170                 175     

Ala Arg Ala Asp Ile Gly Arg His Asn Ala Leu Asp Lys Ile Tyr Gly 
            180                 185                 190         

His Cys Leu Arg Ala Gly Glu Arg Leu Ser Gly Thr Ala Val Ala Phe 
        195                 200                 205             

Ser Gly Arg Ile Ser Ser Glu Val Leu Leu Lys Val Ala Lys Ile Gly 
    210                 215                 220                 

Val Gly Val Val Ile Ala Arg Gly Ala Pro Thr Leu Leu Ala Val Asp 
225                 230                 235                 240 

Leu Ala Glu Glu Leu Asn Ile Thr Ala Ile Gly Phe Val Arg Gly Arg 
                245                 250                 255     

Ala Phe Asn Val Tyr Ser His Pro Trp Arg Leu Ala Asp Ala Lys Lys 
            260                 265                 270         

Ala Gln Gly Ala Ile Glu Gly Ala 
        275                 280 

<210>   489
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   489
gtgaatggcg tgtcgcgctt tgggggagcg gaaacgcgga ggcgcttcgt gctccgatat       60

cggtccgggg agtataaaca ggaggaggac gtgatcgcga cggaattcgc actcacgctg      120

ttcgtcaacg gcgaggagtt ctcgacgctc gtgtgcacgc cgacctacgc ggaggacctg      180

gtgtatggct ttctcgcttc ggaaggcgtc atccgcgacg tggacgacgt cgagtcgatt      240

cgggtgagcc tgtggacggg aacggcccgt gtacagacga agtccggcgc ggtgctttcc      300

ccggcgcttt acaacaaacg gtacatcggg tcttgttgcg ggaaggggcg acagagcttc      360

tatttccaga gcgacgccct gaccgcgcga cccgtcgagg atccggtgtc gctctcggcg      420

gacgacgtgt ttcgggcgat ggatctcctc gacgcgtcgt ccgggctgtt cgaggaaacg      480

ggcggtgtgc acgtggcggc gctggtgcgt gaaggacagc tcgtcttggc gagggccgac      540

attggccgcc acaacgcgct cgacaagatc tacggccact gcctccgggc cggcgagagg      600

ttgtccggca ccgccgtggc gttcagcggc cggatctcgt ccgaggtgtt gctcaaggtc      660

gccaagatcg gtgtgggcgt cgtgatcgcc cgaggagctc cgacgctgct cgccgtcgat      720

ctcgccgagg aactgaacat cacggccatc ggttttgtgc gcggccgggc cttcaacgtg      780

tacagtcatc cgtggcgctt ggcggacgcc aagaaggcgc agggcgccat cgaaggggca      840

tga                                                                    843


<210>   490
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   490
gtgaatggcg tgtcgcgctt tgggggagcg gaaacgcgga aacgcttcgt gctccgatat       60

cggtccgggg agtatcggca ggaggaggac gtgatcgcga cggaattcgc actcacgctg      120

ttcgtcaacg gcgaggagtt ctcgacgctc gtgtgcacgc cgacctacgc ggaggacctg      180

gtgtatggct ttctcgcttc ggaaggcgtc atccgcgacg tggacgacgt cgagtcgatt      240

cgggtgagcc tgtggacggg aacggcccgt gtacagacga agtccggcgc ggtgctttcc      300

ccggcgcttt acaacaaacg gtacatcggg tcttgttgcg ggaaggggcg acagagcttc      360

tatttccaga gcgacgccct gaccgcgcga cccgtcgagg atccggtgtc gctctcggcg      420

gacgacgtgt ttcgggcgat ggatctcctc gacgcgtcgt ccgggctgtt cgaggaaacg      480

ggcggtgtgc acgtggcggc gctggtgcgt gaaggacagc tcgtcttggc gagggccgac      540

attggccgcc acaacgcgct cgacaagatc tacggccact gcctccgggc cggcgagagg      600

ttgtccggca ccgccgtggc gttcagcggc cggatctcgt ccgaggtgtt gctcaaggtc      660

gccaagatcg gtgtgggcgt cgtgatcgcc cgaggagctc cgacgctgct cgccgtcgat      720

ctcgccgagg aactgaacat cacggccatc ggttttgtgc gcggccgggc cttcaacgtg      780

tacagtcatc cgtggcgctt ggcggacgcc aagaaggcgc agggcgccat cgaaggggca      840

tga                                                                    843


<210>   491
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   491
gtgaatggcg tgtcgcgctt tgggggagcg gaaacgcgga ggcgcttcgt gctccgatat       60

cggtccgggg agtatcggca ggaggaggac gtgatcgcga cggaattcgc actcacgctg      120

ttcgtcaacg gcgaggagtt ctcgacgctc gtgtgcacgc cgacctacgc ggaggacctg      180

gtgtatggct ttctcgcttc ggaaggcgtc atccgcgacg tggacgacgt cgagtcgatt      240

cgggtgagcc tgtggacggg aacggcccgt gtacagacga agtccggcgc ggtgctttcc      300

ccggcgcttt acaacaaacg gtacatcggg tcttgttgcg ggaaggggcg acagagcttc      360

tatttcaata gcgacgccct gaccgcgcga cccgtcgagg atccggtgtc gctctcggcg      420

gacgacgtgt ttcgggcgat ggatctcctc gacgcgtcgt ccgggctgtt cgaggaaacg      480

ggcggtgtgc acgtggcggc gctggtgcgt gaaggacagc tcgtcttggc gagggccgac      540

attggccgcc acaacgcgct cgacaagatc tacggccact gcctccgggc cggcgagagg      600

ttgtccggca ccgccgtggc gttcagcggc cggatctcgt ccgaggtgtt gctcaaggtc      660

gccaagatcg gtgtgggcgt cgtgatcgcc cgaggagctc cgacgctgct cgccgtcgat      720

ctcgccgagg aactgaacat cacggccatc ggttttgtgc gcggccgggc cttcaacgtg      780

tacagtcatc cgtggcgctt ggcggacgcc aagaaggcgc agggcgccat cgaaggggca      840

tga                                                                    843


<210>   492
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   492
gtgaatggcg tgtcgcgctt tgggggagcg gaaacgcgga ggcgcttcgt gctccgatat       60

cggtccgggg agtatcggca ggaggaggac gtgatcgcga cggaattcgc actcacgctg      120

ttcgtcaacg gcgaggagtt ctcgacgctc gtgtgcacgc cgacctacgc ggaggacctg      180

gtgtatggct ttctcgcttc ggaaggcgtc atccgcgacg tggacgacgt cgagtcgatt      240

cgggtgagcc tgtggacggg aacggcccgt gtacagacga agtccggcgc ggtgctttcc      300

ccggcgcttt acaacaaacg gtacatcggg tcttgttgcg ggaaggggcg acagagcttc      360

tatttccaga gcgacgccct gaccgcgcga cccgtcgagg atccggtgtc gctctcggcg      420

gacgacgtgt ttcgggcgat ggatctcctc gacgcgtcgt ccgggctgtt cgaggaaacg      480

ggcggtgtgc acgtggcggc gctggtgcgt gaaggacagc tcgtcttggc gagggccgac      540

attggccgcc acaacgcgct cgacaagatc tacggccact gcctccgggc cggcgagaaa      600

ttgtccggca ccgccgtggc gttcagcggc cggatctcgt ccgaggtgtt gctcaaggtc      660

gccaagatcg gtgtgggcgt cgtgatcgcc cgaggagctc cgacgctgct cgccgtcgat      720

ctcgccgagg aactgaacat cacggccatc ggttttgtgc gcggccgggc cttcaacgtg      780

tacagtcatc cgtggcgctt ggcggacgcc aagaaggcgc agggcgccat cgaaggggca      840

tga                                                                    843


<210>   493
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   493
gtgaatggcg tgtcgcgctt tgggggagcg gaaacgcgga ggcgcttcgt gctccgatat       60

cggtccgggg agtatcggca ggaggaggac gtgatcgcga cggaattcgc actcacgctg      120

ttcgtcaacg gcgaggagtt ctcgacgctc gtgtgcacgc cgacctacgc ggaggacctg      180

gtgtatggct ttctcgcttc ggaaggcgtc atccgcgacg tggacgacgt cgagtcgatt      240

cgggtgagcc tgtggacggg aacggcccgt gtacagacga agtccggcgc ggtgctttcc      300

ccggcgcttt accaaaaacg gtacatcggg tcttgttgcg ggaaggggcg acagagcttc      360

tatttccaga gcgacgccct gaccgcgcga cccgtcgagg atccggtgtc gctctcggcg      420

gacgacgtgt ttcgggcgat ggatctcctc gacgcgtcgt ccgggctgtt cgaggaaacg      480

ggcggtgtgc acgtggcggc gctggtgcgt gaaggacagc tcgtcttggc gagggccgac      540

attggccgcc acaacgcgct cgacaagatc tacggccact gcctccgggc cggcgagagg      600

ttgtccggca ccgccgtggc gttcagcggc cggatctcgt ccgaggtgtt gctcaaggtc      660

gccaagatcg gtgtgggcgt cgtgatcgcc cgaggagctc cgacgctgct cgccgtcgat      720

ctcgccgagg aactgaacat cacggccatc ggttttgtgc gcggccgggc cttcaacgtg      780

tacagtcatc cgtggcgctt ggcggacgcc aagaaggcgc agggcgccat cgaaggggca      840

tga                                                                    843


<210>   494
<211>   249
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   494
Met Ala Lys Gly Gly Glu Arg Met Asp Lys Ala Gly Gly Ile Arg Val 
                5                   10                  15      

Ala Leu Ala Gly Ala Leu Gly Arg Met Gly Gln Val Ala Leu Glu Ala 
            20                  25                  30          

Leu Arg Arg Glu Asp Asp Ile Ala Ile Cys Gly Val Leu Val Arg Arg 
        35                  40                  45              

Ala Asp Glu Glu Ala Glu Arg Arg Leu Ser Thr Tyr Gly Ala Val Tyr 
    50                  55                  60                  

Asp Asp Pro Glu Arg Leu Ile Asp Thr Glu Glu Pro Asp Val Trp Val 
65                  70                  75                  80  

Asp Leu Thr Gly Pro Ala Ser Val Val Arg His Val Asp Leu Ala Leu 
                85                  90                  95      

Ser Arg Gly Val Arg Ala Val Val Gly Ala Thr Gly Tyr Thr Asp Glu 
            100                 105                 110         

Asp Val Arg Arg Trp Asp Glu Met Ala Arg His Arg Gln Val Gly Ala 
        115                 120                 125             

Ala Val Cys Pro Asn Phe Ala Ile Gly Ala Leu Leu Met Met Arg Phe 
    130                 135                 140                 

Ala Arg Glu Ala Ala Arg Phe Leu Pro Arg Ala Glu Ile Ile Glu Leu 
145                 150                 155                 160 

His His Asp Gly Lys Arg Asp Lys Pro Ser Gly Thr Ser Leu Arg Thr 
                165                 170                 175     

Lys Ala Met Met Glu Val Glu Tyr Asp Val Pro Ile His Ser Val Arg 
            180                 185                 190         

Leu Pro Gly Leu Val Ala His Gln Glu Val Ile Phe Gly Gly Ala Gly 
        195                 200                 205             

Glu Val Leu Thr Ile Arg His Asp Ser Leu Ser Arg Glu Ser Phe Met 
    210                 215                 220                 

Pro Gly Leu Ile Leu Ala Val Arg Arg Val Met Thr Leu Arg Ala Leu 
225                 230                 235                 240 

Val Tyr Gly Leu Asp Lys Leu Leu Trp 
                245                 

<210>   495
<211>   750
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   495
atggccaagg ggggcgagcg gatggataag gcgggtggca tccgggtggc actggcagga       60

gcgctgggcc gcatggggca ggtggcgctc gaggcgcttc ggcgcgagga cgacatcgcc      120

atctgcgggg tgttggtgcg gcgcgccgac gaagaagccg agcgaaggct ctccacttac      180

ggcgcggtgt acgacgaccc ggagcgactg atcgacacgg aagagcccga cgtgtgggtg      240

gacctgaccg gcccagcgtc ggtggttcgc catgtcgatc tggccctttc tcgcggcgtg      300

cgggcggtgg tgggggcgac cggttacacc gacgaggacg tgcgcagatg ggacgaaatg      360

gcgcgccatc ggcaagtcgg cgcggccgtc tgcccgaact tcgcgatagg ggcgcttctc      420

atgatgcgat tcgcgcgcga ggcggcgcgc ttcctgccgc gcgcggagat cattgagctt      480

caccatgacg gcaagcggga caagccgtcc ggcacgtcgc tgaggacgaa ggccatgatg      540

gaggtcgagt acgacgtgcc gattcacagc gtgcgcctgc cggggcttgt ggcgcaccaa      600

gaagtgattt tcggcggcgc cggcgaagtg ctgaccattc gtcacgattc ccttagccgc      660

gagagcttca tgcccggcct catcctggcc gtgcggcgcg tcatgacgct tcgcgcgctg      720

gtgtacgggt tggacaaact cctctggtga                                       750


<210>   496
<211>   262
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   496
Ile Arg Ile Ala Ile Ala Gly Pro Arg Gly Arg Met Gly Arg Glu Ala 
                5                   10                  15      

Val Ala Leu Val Gln Gln Thr Asp His Phe Glu Leu Ala Ala Val Ile 
            20                  25                  30          

Asp Arg Arg Tyr Asp Gly Gln Asn Leu Ala Glu Ile Asp Gly Phe Ser 
        35                  40                  45              

Gly Val Asn Ala Pro Ile Tyr Thr Asp Ala Ala Arg Cys Phe Ala Glu 
    50                  55                  60                  

Val Lys Pro Asp Val Leu Ile Asp Leu Thr Thr Pro Glu Ala Gly Lys 
65                  70                  75                  80  

Arg His Thr Glu Leu Ala Leu Arg Tyr Gly Val Arg Pro Val Val Gly 
                85                  90                  95      

Thr Thr Gly Phe Thr Pro Glu Asp Ile Glu Arg Leu Thr Lys Leu Ala 
            100                 105                 110         

Glu Glu Lys Glu Ile Gly Ala Ile Ile Ala Pro Asn Phe Ala Val Gly 
        115                 120                 125             

Ala Val Leu Met Met Lys Phe Ala Arg Met Ala Ala Lys Tyr Phe Thr 
    130                 135                 140                 

Asp Val Glu Ile Ile Glu Leu His His Asp Gln Lys Leu Asp Ala Pro 
145                 150                 155                 160 

Ser Gly Thr Ala Leu Lys Thr Ala Gln Leu Ile Ala Glu Val Arg Pro 
                165                 170                 175     

Ser Lys Lys Gln Gly His Pro Asn Glu Lys Glu Thr Leu Ala Gly Ala 
            180                 185                 190         

Arg Gly Ala Glu Tyr Asp Gly Ile Pro Ile His Ser Val Arg Leu Pro 
        195                 200                 205             

Gly Phe Val Ala His Gln Glu Val Ile Phe Gly Gly Asn Gly Gln Thr 
    210                 215                 220                 

Leu Thr Ile Arg His Asp Ser Phe Asp Arg Arg Ser Phe Met Ser Gly 
225                 230                 235                 240 

Val Lys Leu Ala Val Glu Thr Val Met His Leu His Thr Leu Val Tyr 
                245                 250                 255     

Gly Leu Glu His Ile Leu 
            260         

<210>   497
<211>   262
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   497
Ile Arg Ile Val Ile Ala Gly Pro Arg Gly Arg Met Gly Arg Glu Ala 
                5                   10                  15      

Val Ala Leu Val Gln Arg Thr Asp His Phe Glu Leu Ala Ala Val Ile 
            20                  25                  30          

Asp Arg Arg Tyr Asp Gly Gln Asn Leu Ala Asp Ile Asp Gly Phe Ala 
        35                  40                  45              

Gly Ile Asp Ala Pro Ile Tyr Thr Asp Ala Val Arg Cys Phe Thr Glu 
    50                  55                  60                  

Val Lys Pro Asp Val Leu Ile Asp Leu Thr Thr Pro Glu Val Gly Lys 
65                  70                  75                  80  

Arg His Ala Glu Leu Ala Leu Arg Tyr Gly Val Arg Pro Val Ile Gly 
                85                  90                  95      

Thr Thr Gly Phe Thr Pro Glu Asp Ile Glu Arg Leu Thr Glu Leu Ala 
            100                 105                 110         

Glu Thr Asn Glu Ile Gly Ala Ile Ile Ala Pro Asn Phe Ala Val Gly 
        115                 120                 125             

Ala Val Leu Met Met Lys Phe Ala Arg Met Ala Ala Lys Tyr Phe Thr 
    130                 135                 140                 

Asp Val Glu Ile Ile Glu Leu His His Asp Gln Lys Leu Asp Ala Pro 
145                 150                 155                 160 

Ser Gly Thr Ala Leu Lys Thr Ala Gln Leu Ile Ala Glu Val Arg Pro 
                165                 170                 175     

Ser Lys Lys Gln Gly His Pro Asp Glu Lys Glu Thr Leu Ala Gly Ala 
            180                 185                 190         

Arg Gly Ala Ala Tyr Asp Gly Ile Pro Ile His Ser Val Arg Leu Pro 
        195                 200                 205             

Gly Phe Val Ala His Gln Glu Val Ile Phe Gly Gly Glu Gly Gln Thr 
    210                 215                 220                 

Leu Thr Ile Arg His Asp Ser Leu Asp Arg Arg Ser Phe Met Ser Gly 
225                 230                 235                 240 

Val Lys Leu Ala Val Glu Thr Val Met His Leu His Thr Leu Val Tyr 
                245                 250                 255     

Gly Leu Glu His Ile Leu 
            260         

<210>   498
<211>   262
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   498
Ile Lys Val Ala Val Ala Gly Pro Arg Gly Lys Met Gly Arg Glu Ala 
                5                   10                  15      

Val Lys Met Ile His Glu Ala Asp Thr Leu Glu Leu Val Ala Val Val 
            20                  25                  30          

Asp Ser Lys His Asp Gly Met Leu Val Arg Gln Leu Asp Gly Leu Pro 
        35                  40                  45              

Pro Ser Asp Ala Pro Val Tyr Asn Glu Leu Glu Arg Cys Leu Thr Ser 
    50                  55                  60                  

Gln Thr Ile Asp Val Leu Val Asp Leu Thr Thr Pro Ala His Gly Lys 
65                  70                  75                  80  

Arg His Met Glu Ile Ala Leu Asp His Gly Val Arg Pro Val Val Gly 
                85                  90                  95      

Thr Thr Gly Phe Thr Asp Glu Asp Ile Thr Asn Leu Arg Lys Lys Ala 
            100                 105                 110         

Glu Glu Lys Gly Ile Gly Ala Ile Ile Ala Pro Asn Phe Ala Ile Gly 
        115                 120                 125             

Ala Ile Leu Met Met Lys Phe Ala Gln Thr Ala Ala Lys Tyr Leu Pro 
    130                 135                 140                 

Asp Val Glu Ile Ile Glu Met His His Asp Arg Lys Leu Asp Ala Pro 
145                 150                 155                 160 

Ser Gly Thr Ala Leu Lys Thr Ala Gln Leu Ile Ser Glu Val Arg Lys 
                165                 170                 175     

Ala Lys Gln Gln Gly His Pro Asp Glu Thr Glu Glu Leu Lys Gly Ala 
            180                 185                 190         

Arg Gly Ala Asp Phe Glu Gly Met Ser Ile His Ser Val Arg Leu Pro 
        195                 200                 205             

Gly Leu Val Ala His Gln Glu Val Leu Phe Gly Gly Val Gly Gln Thr 
    210                 215                 220                 

Leu Lys Ile Arg His Asp Ser Met Asn Arg Glu Ser Phe Met Pro Gly 
225                 230                 235                 240 

Val Lys Leu Ser Ile Glu Thr Val Met Gly Ile Asp Thr Leu Val Tyr 
                245                 250                 255     

Gly Leu Glu Asn Ile Ile 
            260         

<210>   499
<211>   262
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   499
Ile Arg Ile Ile Val Ala Gly Ala Arg Gly Lys Met Gly Ser Glu Ala 
                5                   10                  15      

Val Arg Leu Ile Glu Arg Thr Glu His Phe Lys Leu Val Gly Val Val 
            20                  25                  30          

Asp Arg Thr Phe Asp Gly Lys Leu Phe Asn Asp Val Ser Asp Tyr Asn 
        35                  40                  45              

Gly Glu Pro Val Arg Val Tyr Thr Asp Pro Glu Ala Cys Leu Glu Asn 
    50                  55                  60                  

Cys Pro Ala Asp Val Trp Ile Asp Leu Thr Val Pro Lys Ala Gly Phe 
65                  70                  75                  80  

Leu His Ala Lys Thr Ala Leu Ala His Gly Val Arg Pro Val Val Gly 
                85                  90                  95      

Thr Thr Gly Phe Thr Asp Ala Glu Leu Glu Glu Leu Lys Ala Val Ser 
            100                 105                 110         

Ala Gln Lys Gly Ile Gly Cys Ile Ile Ala Pro Asn Phe Ala Ile Gly 
        115                 120                 125             

Ala Val Leu Met Met Lys Phe Ala Gln Met Ala Ala Lys Tyr Phe Pro 
    130                 135                 140                 

Asp Val Glu Ile Ile Glu Leu His His Asp Arg Lys Lys Asp Ala Pro 
145                 150                 155                 160 

Ser Gly Thr Ser Val Lys Thr Ala Gln Met Ile Ser Glu Ala Arg Arg 
                165                 170                 175     

Lys Lys Thr Gln Gly His Pro Asp Glu Lys Glu Thr Leu Gln Gly Ala 
            180                 185                 190         

Arg Gly Ala Asp Phe Glu Gly Met His Ile His Ser Val Arg Leu Pro 
        195                 200                 205             

Gly Leu Val Ala His Gln Glu Val Leu Phe Gly Gly Asp Gly Gln Leu 
    210                 215                 220                 

Leu Thr Ile Arg His Asp Ser Met Asp Arg Ala Ser Phe Met Ser Gly 
225                 230                 235                 240 

Val Lys Val Ala Val Glu Thr Val Met Asn Leu Asn Thr Phe Val Tyr 
                245                 250                 255     

Gly Leu Glu Asn Ile Leu 
            260         

<210>   500
<211>   261
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   500
Arg Ile Val Ile Ala Gly Pro Arg Gly Asn Met Gly Gln Glu Ala Val 
                5                   10                  15      

Lys Leu Cys Leu Arg Glu Glu Ser Phe Glu Leu Val Ala Val Val Asp 
            20                  25                  30          

Ser Lys Asn Asp Gly Lys Gln Leu Lys Gly Leu Gln Glu Phe Gln Gln 
        35                  40                  45              

Gly Asp Val Pro Val Tyr Thr Asp Met Ala Arg Cys Phe Ala Glu His 
    50                  55                  60                  

Glu Pro Asp Val Leu Ile Asp Leu Thr Ala Pro Ala Phe Gly Arg Lys 
65                  70                  75                  80  

His Met Glu Val Ala Phe Glu His Gly Val Arg Pro Val Val Gly Thr 
                85                  90                  95      

Thr Gly Phe Ser Asp Glu Asp Ile Arg Asp Leu Thr Lys Leu Ala Glu 
            100                 105                 110         

Ala Lys Glu Leu Gly Ala Ile Ile Ala Pro Asn Phe Ala Ile Gly Ala 
        115                 120                 125             

Ile Leu Met Met Lys Phe Ala Gln Thr Ala Ala Arg Tyr Met Asn Asp 
    130                 135                 140                 

Val Glu Ile Ile Glu Gln His His Asp Arg Lys Leu Asp Ala Pro Ser 
145                 150                 155                 160 

Gly Thr Ala Val Lys Thr Ala Gln Leu Ile Ala Glu Val Arg Ala Pro 
                165                 170                 175     

Lys Lys Gln Gly His Glu Gln Glu Arg Glu Glu Met Ala Gly Ala Arg 
            180                 185                 190         

Gly Ala Asp Phe Asp Gly Met Lys Ile His Ser Val Arg Leu Pro Gly 
        195                 200                 205             

Arg Val Ala His Gln Glu Val Leu Phe Gly Gly Val Gly Gln Thr Leu 
    210                 215                 220                 

Ser Ile Arg His Asp Ser Leu Asn Arg Glu Ser Phe Met Pro Gly Val 
225                 230                 235                 240 

Lys Leu Ala Val Glu Gln Val Val Lys Leu Ser Thr Leu Val Tyr Gly 
                245                 250                 255     

Leu Glu Asn Leu Ile 
            260     

<210>   501
<211>   249
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   501
Met Ala Lys Gly Gly Glu Arg Met Asp Lys Ala Gly Gly Ile Arg Val 
                5                   10                  15      

Ala Leu Ala Gly Ala Leu Gly Arg Met Gly Gln Val Ala Leu Glu Ala 
            20                  25                  30          

Leu Lys Arg Glu Asp Asp Ile Ala Ile Cys Gly Val Leu Val Arg Arg 
        35                  40                  45              

Ala Asp Glu Glu Ala Glu Arg Arg Leu Ser Thr Tyr Gly Ala Val Tyr 
    50                  55                  60                  

Asp Asp Pro Glu Arg Leu Ile Asp Thr Glu Glu Pro Asp Val Trp Val 
65                  70                  75                  80  

Asp Leu Thr Gly Pro Ala Ser Val Val Arg His Val Asp Leu Ala Leu 
                85                  90                  95      

Ser Arg Gly Val Arg Ala Val Val Gly Ala Thr Gly Tyr Thr Asp Glu 
            100                 105                 110         

Asp Val Arg Arg Trp Asp Glu Met Ala Arg His Arg Gln Val Gly Ala 
        115                 120                 125             

Ala Val Cys Pro Asn Phe Ala Ile Gly Ala Leu Leu Met Met Arg Phe 
    130                 135                 140                 

Ala Arg Glu Ala Ala Arg Phe Leu Pro Arg Ala Glu Ile Ile Glu Leu 
145                 150                 155                 160 

His His Asp Gly Lys Arg Asp Lys Pro Ser Gly Thr Ser Leu Arg Thr 
                165                 170                 175     

Lys Ala Met Met Glu Val Glu Tyr Asp Val Pro Ile His Ser Val Arg 
            180                 185                 190         

Leu Pro Gly Leu Val Ala His Gln Glu Val Ile Phe Gly Gly Ala Gly 
        195                 200                 205             

Glu Val Leu Thr Ile Arg His Asp Ser Leu Ser Arg Glu Ser Phe Met 
    210                 215                 220                 

Pro Gly Leu Ile Leu Ala Val Arg Arg Val Met Thr Leu Arg Ala Leu 
225                 230                 235                 240 

Val Tyr Gly Leu Asp Lys Leu Leu Trp 
                245                 

<210>   502
<211>   249
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   502
Met Ala Lys Gly Gly Glu Arg Met Asp Lys Ala Gly Gly Ile Arg Val 
                5                   10                  15      

Ala Leu Ala Gly Ala Leu Gly Arg Met Gly Gln Val Ala Leu Asp Ala 
            20                  25                  30          

Leu Arg Arg Glu Asp Asp Ile Ala Ile Cys Gly Val Leu Val Arg Arg 
        35                  40                  45              

Ala Asp Glu Glu Ala Glu Arg Arg Leu Ser Thr Tyr Gly Ala Val Tyr 
    50                  55                  60                  

Asp Asp Pro Glu Arg Leu Ile Asp Thr Glu Glu Pro Asp Val Trp Val 
65                  70                  75                  80  

Asp Leu Thr Gly Pro Ala Ser Val Val Arg His Val Asp Leu Ala Leu 
                85                  90                  95      

Ser Arg Gly Val Arg Ala Val Val Gly Ala Thr Gly Tyr Thr Asp Glu 
            100                 105                 110         

Asp Val Arg Arg Trp Asp Glu Met Ala Arg His Arg Gln Val Gly Ala 
        115                 120                 125             

Ala Val Cys Pro Asn Phe Ala Ile Gly Ala Leu Leu Met Met Arg Phe 
    130                 135                 140                 

Ala Arg Glu Ala Ala Arg Phe Leu Pro Arg Ala Glu Ile Ile Glu Leu 
145                 150                 155                 160 

His His Asp Gly Lys Arg Asp Lys Pro Ser Gly Thr Ser Leu Arg Thr 
                165                 170                 175     

Lys Ala Met Met Glu Val Glu Tyr Asp Val Pro Ile His Ser Val Arg 
            180                 185                 190         

Leu Pro Gly Leu Val Ala His Gln Glu Val Ile Phe Gly Gly Ala Gly 
        195                 200                 205             

Glu Val Leu Thr Ile Arg His Asp Ser Leu Ser Arg Glu Ser Phe Met 
    210                 215                 220                 

Pro Gly Leu Ile Leu Ala Val Arg Arg Val Met Thr Leu Arg Ala Leu 
225                 230                 235                 240 

Val Tyr Gly Leu Asp Lys Leu Leu Trp 
                245                 

<210>   503
<211>   249
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   503
Met Ala Lys Gly Gly Glu Arg Met Asp Lys Ala Gly Gly Ile Arg Val 
                5                   10                  15      

Ala Leu Ala Gly Ala Leu Gly Arg Met Gly Gln Val Ala Leu Glu Ala 
            20                  25                  30          

Leu Arg Arg Glu Asp Asp Ile Ala Ile Cys Gly Val Leu Val Arg Arg 
        35                  40                  45              

Ala Asp Glu Glu Ala Glu Arg Arg Leu Ser Thr Tyr Gly Ala Val Tyr 
    50                  55                  60                  

Asp Asp Pro Glu Arg Leu Ile Asp Thr Glu Glu Pro Asp Val Trp Val 
65                  70                  75                  80  

Asp Leu Thr Gly Pro Ala Ser Val Val Arg His Val Asp Leu Ala Leu 
                85                  90                  95      

Ser Arg Gly Val Arg Ala Val Val Gly Ala Thr Gly Tyr Thr Asp Glu 
            100                 105                 110         

Asp Val Arg Arg Trp Asp Glu Met Ala Arg His Arg Gln Val Gly Ala 
        115                 120                 125             

Ala Val Cys Pro Asn Phe Ala Ile Gly Ala Leu Leu Met Met Arg Phe 
    130                 135                 140                 

Ala Arg Glu Ala Ala Arg Phe Leu Pro Arg Ala Glu Ile Ile Glu Leu 
145                 150                 155                 160 

His His Asp Gly Lys Arg Asp Arg Pro Ser Gly Thr Ser Leu Arg Thr 
                165                 170                 175     

Lys Ala Met Met Glu Val Glu Tyr Asp Val Pro Ile His Ser Val Arg 
            180                 185                 190         

Leu Pro Gly Leu Val Ala His Gln Glu Val Ile Phe Gly Gly Ala Gly 
        195                 200                 205             

Glu Val Leu Thr Ile Arg His Asp Ser Leu Ser Arg Glu Ser Phe Met 
    210                 215                 220                 

Pro Gly Leu Ile Leu Ala Val Arg Arg Val Met Thr Leu Arg Ala Leu 
225                 230                 235                 240 

Val Tyr Gly Leu Asp Lys Leu Leu Trp 
                245                 

<210>   504
<211>   249
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   504
Met Ala Lys Gly Gly Glu Arg Met Asp Lys Ala Gly Gly Ile Arg Val 
                5                   10                  15      

Ala Leu Ala Gly Ala Leu Gly Arg Met Gly Gln Val Ala Leu Glu Ala 
            20                  25                  30          

Leu Arg Arg Glu Asp Asp Ile Ala Ile Cys Gly Val Leu Val Arg Arg 
        35                  40                  45              

Ala Asp Asp Glu Ala Glu Arg Arg Leu Ser Thr Tyr Gly Ala Val Tyr 
    50                  55                  60                  

Asp Asp Pro Glu Arg Leu Ile Asp Thr Glu Glu Pro Asp Val Trp Val 
65                  70                  75                  80  

Asp Leu Thr Gly Pro Ala Ser Val Val Arg His Val Asp Leu Ala Leu 
                85                  90                  95      

Ser Arg Gly Val Arg Ala Val Val Gly Ala Thr Gly Tyr Thr Asp Glu 
            100                 105                 110         

Asp Val Arg Arg Trp Asp Glu Met Ala Arg His Arg Gln Val Gly Ala 
        115                 120                 125             

Ala Val Cys Pro Asn Phe Ala Ile Gly Ala Leu Leu Met Met Arg Phe 
    130                 135                 140                 

Ala Arg Glu Ala Ala Arg Phe Leu Pro Arg Ala Glu Ile Ile Glu Leu 
145                 150                 155                 160 

His His Asp Gly Lys Arg Asp Lys Pro Ser Gly Thr Ser Leu Arg Thr 
                165                 170                 175     

Lys Ala Met Met Glu Val Glu Tyr Asp Val Pro Ile His Ser Val Arg 
            180                 185                 190         

Leu Pro Gly Leu Val Ala His Gln Glu Val Ile Phe Gly Gly Ala Gly 
        195                 200                 205             

Glu Val Leu Thr Ile Arg His Asp Ser Leu Ser Arg Glu Ser Phe Met 
    210                 215                 220                 

Pro Gly Leu Ile Leu Ala Val Arg Arg Val Met Thr Leu Arg Ala Leu 
225                 230                 235                 240 

Val Tyr Gly Leu Asp Lys Leu Leu Trp 
                245                 

<210>   505
<211>   249
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   505
Met Ala Lys Gly Gly Glu Arg Met Asp Lys Ala Gly Gly Ile Arg Val 
                5                   10                  15      

Ala Leu Ala Gly Ala Leu Gly Arg Met Gly Gln Val Ala Leu Glu Ala 
            20                  25                  30          

Leu Arg Arg Glu Asp Asp Ile Ala Ile Cys Gly Val Leu Val Arg Arg 
        35                  40                  45              

Ala Asp Glu Glu Ala Glu Arg Arg Leu Ser Thr Tyr Gly Ala Val Tyr 
    50                  55                  60                  

Asp Asp Pro Glu Arg Leu Ile Asp Thr Glu Glu Pro Asp Val Trp Val 
65                  70                  75                  80  

Asp Leu Thr Gly Pro Ala Ser Val Val Arg His Val Asp Leu Ala Leu 
                85                  90                  95      

Ser Arg Gly Val Arg Ala Val Val Gly Ala Thr Gly Tyr Thr Asp Glu 
            100                 105                 110         

Asp Val Arg Arg Trp Asp Glu Met Ala Arg His Arg Gln Val Gly Ala 
        115                 120                 125             

Ala Val Cys Pro Asn Phe Ala Ile Gly Ala Leu Leu Met Met Arg Phe 
    130                 135                 140                 

Ala Arg Glu Ala Ala Arg Phe Leu Pro Arg Ala Glu Ile Ile Glu Leu 
145                 150                 155                 160 

His His Asp Gly Lys Arg Asp Lys Pro Ser Gly Thr Ser Leu Arg Thr 
                165                 170                 175     

Lys Ala Met Met Glu Val Glu Tyr Asp Val Pro Ile His Ser Val Arg 
            180                 185                 190         

Leu Pro Gly Ile Val Ala His Gln Glu Val Ile Phe Gly Gly Ala Gly 
        195                 200                 205             

Glu Val Leu Thr Ile Arg His Asp Ser Leu Ser Arg Glu Ser Phe Met 
    210                 215                 220                 

Pro Gly Leu Ile Leu Ala Val Arg Arg Val Met Thr Leu Arg Ala Leu 
225                 230                 235                 240 

Val Tyr Gly Leu Asp Lys Leu Leu Trp 
                245                 

<210>   506
<211>   750
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   506
atggccaagg ggggcgagcg gatggataag gcgggtggca tccgggtggc actggcagga       60

gcgctgggcc gcatggggca ggtggcgctc gaggcgctta aacgcgagga cgacatcgcc      120

atctgcgggg tgttggtgcg gcgcgccgac gaagaagccg agcgaaggct ctccacttac      180

ggcgcggtgt acgacgaccc ggagcgactg atcgacacgg aagagcccga cgtgtgggtg      240

gacctgaccg gcccagcgtc ggtggttcgc catgtcgatc tggccctttc tcgcggcgtg      300

cgggcggtgg tgggggcgac cggttacacc gacgaggacg tgcgcagatg ggacgaaatg      360

gcgcgccatc ggcaagtcgg cgcggccgtc tgcccgaact tcgcgatagg ggcgcttctc      420

atgatgcgat tcgcgcgcga ggcggcgcgc ttcctgccgc gcgcggagat cattgagctt      480

caccatgacg gcaagcggga caagccgtcc ggcacgtcgc tgaggacgaa ggccatgatg      540

gaggtcgagt acgacgtgcc gattcacagc gtgcgcctgc cggggcttgt ggcgcaccaa      600

gaagtgattt tcggcggcgc cggcgaagtg ctgaccattc gtcacgattc ccttagccgc      660

gagagcttca tgcccggcct catcctggcc gtgcggcgcg tcatgacgct tcgcgcgctg      720

gtgtacgggt tggacaaact cctctggtga                                       750


<210>   507
<211>   750
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   507
atggccaagg ggggcgagcg gatggataag gcgggtggca tccgggtggc actggcagga       60

gcgctgggcc gcatggggca ggtggcgctc gatgcgcttc ggcgcgagga cgacatcgcc      120

atctgcgggg tgttggtgcg gcgcgccgac gaagaagccg agcgaaggct ctccacttac      180

ggcgcggtgt acgacgaccc ggagcgactg atcgacacgg aagagcccga cgtgtgggtg      240

gacctgaccg gcccagcgtc ggtggttcgc catgtcgatc tggccctttc tcgcggcgtg      300

cgggcggtgg tgggggcgac cggttacacc gacgaggacg tgcgcagatg ggacgaaatg      360

gcgcgccatc ggcaagtcgg cgcggccgtc tgcccgaact tcgcgatagg ggcgcttctc      420

atgatgcgat tcgcgcgcga ggcggcgcgc ttcctgccgc gcgcggagat cattgagctt      480

caccatgacg gcaagcggga caagccgtcc ggcacgtcgc tgaggacgaa ggccatgatg      540

gaggtcgagt acgacgtgcc gattcacagc gtgcgcctgc cggggcttgt ggcgcaccaa      600

gaagtgattt tcggcggcgc cggcgaagtg ctgaccattc gtcacgattc ccttagccgc      660

gagagcttca tgcccggcct catcctggcc gtgcggcgcg tcatgacgct tcgcgcgctg      720

gtgtacgggt tggacaaact cctctggtga                                       750


<210>   508
<211>   750
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   508
atggccaagg ggggcgagcg gatggataag gcgggtggca tccgggtggc actggcagga       60

gcgctgggcc gcatggggca ggtggcgctc gaggcgcttc ggcgcgagga cgacatcgcc      120

atctgcgggg tgttggtgcg gcgcgccgac gaagaagccg agcgaaggct ctccacttac      180

ggcgcggtgt acgacgaccc ggagcgactg atcgacacgg aagagcccga cgtgtgggtg      240

gacctgaccg gcccagcgtc ggtggttcgc catgtcgatc tggccctttc tcgcggcgtg      300

cgggcggtgg tgggggcgac cggttacacc gacgaggacg tgcgcagatg ggacgaaatg      360

gcgcgccatc ggcaagtcgg cgcggccgtc tgcccgaact tcgcgatagg ggcgcttctc      420

atgatgcgat tcgcgcgcga ggcggcgcgc ttcctgccgc gcgcggagat cattgagctt      480

caccatgacg gcaagcggga ccgtccgtcc ggcacgtcgc tgaggacgaa ggccatgatg      540

gaggtcgagt acgacgtgcc gattcacagc gtgcgcctgc cggggcttgt ggcgcaccaa      600

gaagtgattt tcggcggcgc cggcgaagtg ctgaccattc gtcacgattc ccttagccgc      660

gagagcttca tgcccggcct catcctggcc gtgcggcgcg tcatgacgct tcgcgcgctg      720

gtgtacgggt tggacaaact cctctggtga                                       750


<210>   509
<211>   750
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   509
atggccaagg ggggcgagcg gatggataag gcgggtggca tccgggtggc actggcagga       60

gcgctgggcc gcatggggca ggtggcgctc gaggcgcttc ggcgcgagga cgacatcgcc      120

atctgcgggg tgttggtgcg gcgcgccgac gatgaagccg agcgaaggct ctccacttac      180

ggcgcggtgt acgacgaccc ggagcgactg atcgacacgg aagagcccga cgtgtgggtg      240

gacctgaccg gcccagcgtc ggtggttcgc catgtcgatc tggccctttc tcgcggcgtg      300

cgggcggtgg tgggggcgac cggttacacc gacgaggacg tgcgcagatg ggacgaaatg      360

gcgcgccatc ggcaagtcgg cgcggccgtc tgcccgaact tcgcgatagg ggcgcttctc      420

atgatgcgat tcgcgcgcga ggcggcgcgc ttcctgccgc gcgcggagat cattgagctt      480

caccatgacg gcaagcggga caagccgtcc ggcacgtcgc tgaggacgaa ggccatgatg      540

gaggtcgagt acgacgtgcc gattcacagc gtgcgcctgc cggggcttgt ggcgcaccaa      600

gaagtgattt tcggcggcgc cggcgaagtg ctgaccattc gtcacgattc ccttagccgc      660

gagagcttca tgcccggcct catcctggcc gtgcggcgcg tcatgacgct tcgcgcgctg      720

gtgtacgggt tggacaaact cctctggtga                                       750


<210>   510
<211>   750
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   510
atggccaagg ggggcgagcg gatggataag gcgggtggca tccgggtggc actggcagga       60

gcgctgggcc gcatggggca ggtggcgctc gaggcgcttc ggcgcgagga cgacatcgcc      120

atctgcgggg tgttggtgcg gcgcgccgac gaagaagccg agcgaaggct ctccacttac      180

ggcgcggtgt acgacgaccc ggagcgactg atcgacacgg aagagcccga cgtgtgggtg      240

gacctgaccg gcccagcgtc ggtggttcgc catgtcgatc tggccctttc tcgcggcgtg      300

cgggcggtgg tgggggcgac cggttacacc gacgaggacg tgcgcagatg ggacgaaatg      360

gcgcgccatc ggcaagtcgg cgcggccgtc tgcccgaact tcgcgatagg ggcgcttctc      420

atgatgcgat tcgcgcgcga ggcggcgcgc ttcctgccgc gcgcggagat cattgagctt      480

caccatgacg gcaagcggga caagccgtcc ggcacgtcgc tgaggacgaa ggccatgatg      540

gaggtcgagt acgacgtgcc gattcacagc gtgcgcctgc cggggattgt ggcgcaccaa      600

gaagtgattt tcggcggcgc cggcgaagtg ctgaccattc gtcacgattc ccttagccgc      660

gagagcttca tgcccggcct catcctggcc gtgcggcgcg tcatgacgct tcgcgcgctg      720

gtgtacgggt tggacaaact cctctggtga                                       750


<210>   511
<211>   307
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   511
Met Gly Glu Arg Arg Gly Phe Gly Leu Lys Lys Leu Ser Ala Ala Ile 
                5                   10                  15      

Val Gly Ser Gly Asn Ile Gly Thr Asp Leu Met Ile Lys Leu Lys Arg 
            20                  25                  30          

Ser Pro Trp Ile Glu Pro Arg Trp Met Ile Gly Ile Asp Pro Glu Ser 
        35                  40                  45              

Asp Gly Leu Arg Arg Ala Arg Glu Met Gly Leu Glu Thr Ser Ala Asp 
    50                  55                  60                  

Gly Leu Lys Ala Val Leu Glu Gln Gly Val Arg Pro Asp Ile Val Phe 
65                  70                  75                  80  

Asp Ala Thr Ser Ala Lys Ala His Val Arg His Ala Lys Leu Leu Arg 
                85                  90                  95      

Glu Ala Gly Ile Gln Ala Val Asp Leu Thr Pro Ala Ala Arg Gly Pro 
            100                 105                 110         

Tyr Val Ile Ala Ala Val Asn Leu Glu Glu His Leu Asp Ser Pro Asn 
        115                 120                 125             

Val Asn Met Val Thr Cys Gly Gly Gln Ala Thr Val Pro Met Val Tyr 
    130                 135                 140                 

Ala Val Ser Arg Val Val Gly Val Arg Tyr Ala Glu Ile Val Ala Thr 
145                 150                 155                 160 

Ile Ala Ser Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu 
                165                 170                 175     

Phe Thr Gln Thr Thr Ala Arg Ala Leu Glu Ala Ile Gly Gly Ala Lys 
            180                 185                 190         

Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro Ala Glu Pro Pro Ile Leu 
        195                 200                 205             

Met Arg Asp Thr Ile Tyr Cys Leu Met Glu Asp Ala Ser Pro Thr Thr 
    210                 215                 220                 

Gln Ala Lys Val Leu Glu Ser Ile Glu Gln Met Val Arg His Val Gln 
225                 230                 235                 240 

Thr Phe Val Pro Gly Tyr Arg Leu Asn Arg Glu Pro Ile Phe Gln Asp 
                245                 250                 255     

Asp Leu Val Ser Ile Ser Ile Glu Val Glu Gly Leu Gly Asp Tyr Leu 
            260                 265                 270         

Pro Val Tyr Ala Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Val Lys 
        275                 280                 285             

Phe Gly Glu Glu Tyr Ala Arg His Lys Met Gln Val Ala Ser Ala Glu 
    290                 295                 300                 

Glu Ala Arg 
305         

<210>   512
<211>   924
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   512
gtgggcgaaa ggagagggtt cggattgaag aagctcagtg ccgcgatcgt cgggtccgga       60

aacatcggga cggatctcat gatcaagctg aagcgaagcc cgtggattga accgcgctgg      120

atgatcggca tcgacccgga atcggatggc cttcggcgcg cgcgcgagat ggggcttgag      180

acgtcggccg acggactcaa ggcggtcctc gaacaagggg tgcgcccgga catcgtcttt      240

gacgcgacga gcgcgaaggc gcacgtgcgc catgccaaac tgcttcgcga agcaggcatc      300

caggcggtcg acttgacgcc ggcagcgcgc gggccgtacg tcatcgcggc ggtcaacctg      360

gaggagcacc tcgactcgcc gaacgttaac atggtcacct gcggcggcca ggccaccgtg      420

ccgatggtgt acgccgtcag ccgggtggtc ggggtgcgtt acgcggagat tgtcgccacc      480

atcgccagca agagcgcggg ccccggcacg cgggcgaaca tcgacgagtt cacccagacg      540

acggcgcgcg cgctggaggc catcggaggc gcaaagcgag ggaaggccat catcatcctc      600

aacccggcgg aaccccccat cctcatgcgc gacaccatct actgcttgat ggaagacgcg      660

agcccgacca cccaggcgaa ggtgctcgag tccatcgaac agatggtgcg ccacgtgcag      720

acattcgtcc ctgggtatcg gttgaaccgc gagcccatct tccaggacga tctcgtcagc      780

atctccatcg aggtcgaggg cctcggcgat tacctgccgg tgtacgcggg gaacctcgac      840

atcatgaccg cggcggcagt gaagtttggc gaagagtacg cgcgtcacaa gatgcaggtg      900

gcgtcggcgg aagaagcgag gtga                                             924


<210>   513
<211>   298
<212>   PRT
<213>   Mycobacterium gilvum PYR-GCK

<400>   513
Lys Leu Ser Val Ala Ile Val Gly Ser Gly Asn Ile Ser Thr Asp Leu 
                5                   10                  15      

Leu Tyr Lys Leu Leu Arg Ser Glu Trp Leu Glu Pro Arg Trp Met Ile 
            20                  25                  30          

Gly Ile Asp Pro Glu Ser Glu Gly Leu Ala Arg Ala Arg Lys Leu Gly 
        35                  40                  45              

Leu Glu Thr Ser His Glu Gly Val Asp Trp Leu Leu Ala Arg Asp Glu 
    50                  55                  60                  

Lys Pro Asp Met Val Phe Glu Ala Thr Ser Ala Tyr Val His Arg Asp 
65                  70                  75                  80  

Ala Ala Pro Arg Tyr Ala Glu Ala Gly Ile Arg Ala Ile Asp Leu Thr 
                85                  90                  95      

Pro Ala Ala Ile Gly Pro Gly Val Ile Pro Pro Ala Asn Leu Arg Glu 
            100                 105                 110         

His Leu Asp Ala Pro Asn Val Asn Met Val Thr Cys Gly Gly Gln Ala 
        115                 120                 125             

Thr Ile Pro Met Val His Ala Val Ser Arg Val Val Asp Val Pro Tyr 
    130                 135                 140                 

Ala Glu Ile Val Ala Ser Val Ser Ser Ala Ser Ala Gly Pro Gly Thr 
145                 150                 155                 160 

Arg Ala Asn Ile Asp Glu Phe Thr Lys Thr Thr Ser Ala Gly Val Glu 
                165                 170                 175     

Val Ile Gly Gly Ala Arg Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro 
            180                 185                 190         

Ala Asp Pro Pro Met Ile Met Arg Asp Thr Ile Phe Cys Ala Ile Pro 
        195                 200                 205             

Glu Asp Ala Asp His Ala Ala Ile Thr Gln Ser Val Lys Asp Val Val 
    210                 215                 220                 

Ala Glu Val Gln Thr Tyr Val Pro Gly Tyr Arg Leu Leu Asn Glu Pro 
225                 230                 235                 240 

Gln Phe Asp Glu Pro Ser Val Val Asn Gly Gly Asn His Leu Val Thr 
                245                 250                 255     

Ile Phe Val Glu Val Glu Gly Ala Gly Asp Tyr Leu Pro Pro Tyr Ala 
            260                 265                 270         

Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Ala Lys Val Gly Glu Glu 
        275                 280                 285             

Ile Ala Arg Glu Arg Val Ala Thr Ser Thr 
    290                 295             

<210>   514
<211>   304
<212>   PRT
<213>   Mycobacterium smegmatis str. MC2 155

<400>   514
Lys Lys Ser Ser Val Ala Ile Val Gly Ser Gly Asn Ile Ser Thr Asp 
                5                   10                  15      

Leu Leu Tyr Lys Leu Leu Arg Ser Glu Trp Leu Glu Pro Arg Trp Met 
            20                  25                  30          

Ile Gly Ile Asp Pro Glu Ser Glu Gly Leu Ala Arg Ala Arg Lys Leu 
        35                  40                  45              

Gly Leu Glu Thr Ser Ala Glu Gly Val Asp Trp Leu Leu Ala Gln Ser 
    50                  55                  60                  

Glu Lys Pro Asp Leu Val Phe Glu Ala Thr Ser Ala Tyr Val His Arg 
65                  70                  75                  80  

Asp Ala Ala Pro Arg Tyr Glu Glu Ala Gly Ile Arg Ala Ile Asp Leu 
                85                  90                  95      

Thr Pro Ala Ala Val Gly Pro Gly Val Val Pro Pro Ala Asn Leu Arg 
            100                 105                 110         

Asp His Leu Asp Ala Pro Asn Val Asn Met Val Thr Cys Gly Gly Gln 
        115                 120                 125             

Ala Thr Ile Pro Ile Val His Ala Val Ser Arg Val Val Asp Val Pro 
    130                 135                 140                 

Tyr Ala Glu Ile Val Ala Ser Val Ser Ser Ala Ser Ala Gly Pro Gly 
145                 150                 155                 160 

Thr Arg Ala Asn Ile Asp Glu Phe Thr Lys Thr Thr Ser Ala Gly Val 
                165                 170                 175     

Gln Asn Ile Gly Gly Ala Gln Arg Gly Lys Ala Ile Ile Val Leu Asn 
            180                 185                 190         

Pro Ala Glu Pro Pro Met Ile Met Arg Asp Thr Ile Phe Cys Ala Ile 
        195                 200                 205             

Pro Glu Gly Ala Asp His Asp Ala Ile Thr Gln Ser Ile Lys Asp Val 
    210                 215                 220                 

Val Ala Glu Val Gln Thr Tyr Val Pro Gly Tyr Arg Leu Leu Asn Glu 
225                 230                 235                 240 

Pro Gln Phe Asp Glu Pro Ser Val Val Asn Gly Gly Asn His Leu Val 
                245                 250                 255     

Thr Thr Phe Val Glu Val Glu Gly Ala Gly Asp Tyr Leu Pro Pro Tyr 
            260                 265                 270         

Ala Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Thr Lys Val Gly Glu 
        275                 280                 285             

Glu Ile Ala Lys Lys Ser Ala Glu Ala Ser Leu Ala Ser Gly Ala Gln 
    290                 295                 300                 

<210>   515
<211>   298
<212>   PRT
<213>   Rhodococcus sp. RHA1

<400>   515
Met Thr Lys Ala Ser Val Ala Ile Val Gly Ser Gly Asn Ile Ser Thr 
                5                   10                  15      

Asp Leu Leu Tyr Lys Leu Gln Arg Ser Glu Trp Leu Glu Pro Arg Trp 
            20                  25                  30          

Met Ile Gly Ile Asp Pro Glu Ser Glu Gly Leu Ala Arg Ala Arg Lys 
        35                  40                  45              

Leu Gly Leu Glu Thr Ser Ala Glu Gly Val Asp Trp Leu Leu Asn Gln 
    50                  55                  60                  

Pro Glu Lys Pro Asp Leu Val Phe Glu Ala Thr Ser Ala Tyr Val His 
65                  70                  75                  80  

Arg Glu Ala Ala Pro Arg Tyr Glu Ala Ala Gly Ile Arg Ala Val Asp 
                85                  90                  95      

Leu Thr Pro Ala Ala Val Gly Pro Ala Val Val Pro Pro Ala Asn Leu 
            100                 105                 110         

Arg Glu His Leu Gly Ala Pro Asn Val Asn Met Ile Thr Cys Gly Gly 
        115                 120                 125             

Gln Ala Thr Ile Pro Ile Val Tyr Ala Val Ser Arg Val Val Asp Val 
    130                 135                 140                 

Pro Tyr Ala Glu Ile Val Ala Ser Val Ala Ser Val Ser Ala Gly Pro 
145                 150                 155                 160 

Gly Thr Arg Ala Asn Ile Asp Glu Phe Thr Lys Thr Thr Ser Arg Gly 
                165                 170                 175     

Ile Glu Thr Ile Gly Gly Ala Gln Arg Gly Lys Ala Ile Ile Ile Leu 
            180                 185                 190         

Asn Pro Ala Asp Pro Pro Met Ile Met Arg Asp Thr Ile Phe Cys Ala 
        195                 200                 205             

Ile Pro Glu Asp Ala Asp Arg Ala Ala Ile Thr Asp Ser Ile His Arg 
    210                 215                 220                 

Val Val Ala Asp Ile Gln Gln Tyr Val Pro Gly Tyr Arg Leu Leu Asn 
225                 230                 235                 240 

Glu Pro Gln Phe Asp Asp Pro Ser Val Val Ser Gly Gly Gln Ala Thr 
                245                 250                 255     

Val Thr Thr Phe Val Glu Val Glu Gly Ala Gly Asp Phe Leu Pro Pro 
            260                 265                 270         

Tyr Ala Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Thr Lys Val Gly 
        275                 280                 285             

Glu Glu Ile Ala Gln Lys Leu Leu Ser Val 
    290                 295             

<210>   516
<211>   294
<212>   PRT
<213>   Mycobacterium vanbaalenii PYR-1

<400>   516
Lys Lys Ser Val Ala Ile Val Gly Ser Gly Asn Ile Ser Thr Asp Leu 
                5                   10                  15      

Leu Tyr Lys Leu Leu Arg Ser Glu Trp Leu Glu Pro Arg Trp Met Ile 
            20                  25                  30          

Gly Ile Asp Pro Glu Ser Glu Gly Leu Ala Arg Ala Arg Lys Leu Gly 
        35                  40                  45              

Leu Glu Thr Ser His Glu Gly Val Asp Trp Leu Leu Ala Gln Ser Glu 
    50                  55                  60                  

Leu Pro Asp Met Val Phe Glu Ala Thr Ser Ala Tyr Val His Lys Ala 
65                  70                  75                  80  

Ala Ala Pro Arg Tyr Ala Glu Ala Gly Ile Arg Ala Ile Asp Leu Thr 
                85                  90                  95      

Pro Ala Ala Val Gly Pro Gly Val Ile Pro Pro Ala Asn Leu Arg Ala 
            100                 105                 110         

His Leu Asp Ala Pro Asn Val Asn Met Val Thr Cys Gly Gly Gln Ala 
        115                 120                 125             

Thr Ile Pro Met Val Tyr Ala Val Ser Arg Val Val Glu Val Pro Tyr 
    130                 135                 140                 

Ala Glu Ile Val Ala Ser Val Ser Ser Ala Ser Ala Gly Pro Gly Thr 
145                 150                 155                 160 

Arg Ala Asn Ile Asp Glu Phe Thr Lys Thr Thr Ser Ala Gly Val Gln 
                165                 170                 175     

Asn Ile Gly Gly Ala Gln Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro 
            180                 185                 190         

Ala Glu Pro Pro Met Ile Met Arg Asp Thr Ile Phe Cys Ala Ile Pro 
        195                 200                 205             

Glu His Ala Asp His Ala Ala Ile Thr Gln Ser Ile Lys Asp Val Val 
    210                 215                 220                 

Ala Glu Val Gln Thr Tyr Val Pro Gly Tyr Arg Leu Leu Asn Glu Pro 
225                 230                 235                 240 

Gln Phe Asp Glu Pro Ser Val Val Asn Gly Gly Asn His Val Val Thr 
                245                 250                 255     

Val Phe Val Glu Val Glu Gly Ala Gly Asp Tyr Leu Pro Pro Tyr Ala 
            260                 265                 270         

Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Thr Lys Val Gly Glu Glu 
        275                 280                 285             

Ile Ala Lys Glu Ser Leu 
    290                 

<210>   517
<211>   297
<212>   PRT
<213>   Mycobacterium avium 104

<400>   517
Lys Ala Lys Val Ala Ile Val Gly Ser Gly Asn Ile Ser Thr Asp Leu 
                5                   10                  15      

Leu Tyr Lys Leu Leu Arg Ser Asp Trp Leu Glu Pro Arg Trp Met Val 
            20                  25                  30          

Gly Ile Asp Pro Gln Ser Glu Gly Leu Ala Arg Ala Arg Lys Leu Gly 
        35                  40                  45              

Leu Glu Thr Thr His Glu Gly Val Asp Trp Leu Leu Ala Gln Pro Glu 
    50                  55                  60                  

Lys Pro Asp Leu Val Phe Glu Ala Thr Ser Ala Tyr Val His Arg Asp 
65                  70                  75                  80  

Ala Ala Pro Lys Tyr Glu Ala Ala Gly Ile Arg Ala Ile Asp Leu Thr 
                85                  90                  95      

Pro Ala Ala Val Gly Pro Ala Val Ile Pro Pro Ala Asn Leu Arg Gln 
            100                 105                 110         

His Leu Asp Ala Pro Asn Val Asn Met Ile Thr Cys Gly Gly Gln Ala 
        115                 120                 125             

Thr Ile Pro Ile Val Tyr Ala Val Ser Arg Val Val Glu Val Pro Tyr 
    130                 135                 140                 

Ala Glu Ile Val Ala Ser Val Ala Ser Val Ser Ala Gly Pro Gly Thr 
145                 150                 155                 160 

Arg Ala Asn Ile Asp Glu Phe Thr Lys Thr Thr Ser Arg Gly Val Glu 
                165                 170                 175     

Thr Ile Gly Gly Ala Lys Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro 
            180                 185                 190         

Ala Asp Pro Pro Met Ile Met Arg Asp Thr Ile Phe Cys Ala Ile Pro 
        195                 200                 205             

Glu Asp Ala Asp Arg Asp Ala Ile Ala Gln Ser Ile His Asp Val Val 
    210                 215                 220                 

Lys Glu Val Gln Ser Tyr Val Pro Gly Tyr Arg Leu Leu Asn Glu Pro 
225                 230                 235                 240 

Gln Phe Asp Asp Pro Ser Leu Asn Ser Gly Gly Gln Ala Leu Val Thr 
                245                 250                 255     

Thr Phe Val Glu Val Glu Gly Ala Gly Asp Tyr Leu Pro Pro Tyr Ala 
            260                 265                 270         

Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Thr Lys Val Gly Glu Glu 
        275                 280                 285             

Ile Ala Lys Glu Thr Leu Ser Val Ala 
    290                 295         

<210>   518
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   518
Met Gly Asp Arg Arg Gly Phe Gly Leu Lys Lys Leu Ser Ala Ala Ile 
                5                   10                  15      

Val Gly Ser Gly Asn Ile Gly Thr Asp Leu Met Ile Lys Leu Lys Arg 
            20                  25                  30          

Ser Pro Trp Ile Glu Pro Arg Trp Met Ile Gly Ile Asp Pro Glu Ser 
        35                  40                  45              

Asp Gly Leu Arg Arg Ala Arg Glu Met Gly Leu Glu Thr Ser Ala Asp 
    50                  55                  60                  

Gly Leu Lys Ala Val Leu Glu Gln Gly Val Arg Pro Asp Ile Val Phe 
65                  70                  75                  80  

Asp Ala Thr Ser Ala Lys Ala His Val Arg His Ala Lys Leu Leu Arg 
                85                  90                  95      

Glu Ala Gly Ile Gln Ala Val Asp Leu Thr Pro Ala Ala Arg Gly Pro 
            100                 105                 110         

Tyr Val Ile Ala Ala Val Asn Leu Glu Glu His Leu Asp Ser Pro Asn 
        115                 120                 125             

Val Asn Met Val Thr Cys Gly Gly Gln Ala Thr Val Pro Met Val Tyr 
    130                 135                 140                 

Ala Val Ser Arg Val Val Gly Val Arg Tyr Ala Glu Ile Val Ala Thr 
145                 150                 155                 160 

Ile Ala Ser Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu 
                165                 170                 175     

Phe Thr Gln Thr Thr Ala Arg Ala Leu Glu Ala Ile Gly Gly Ala Lys 
            180                 185                 190         

Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro Ala Glu Pro Pro Ile Leu 
        195                 200                 205             

Met Arg Asp Thr Ile Tyr Cys Leu Met Glu Asp Ala Ser Pro Thr Thr 
    210                 215                 220                 

Gln Ala Lys Val Leu Glu Ser Ile Glu Gln Met Val Arg His Val Gln 
225                 230                 235                 240 

Thr Phe Val Pro Gly Tyr Arg Leu Asn Arg Glu Pro Ile Phe Gln Asp 
                245                 250                 255     

Asp Leu Val Ser Ile Ser Ile Glu Val Glu Gly Leu Gly Asp Tyr Leu 
            260                 265                 270         

Pro Val Tyr Ala Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Val Lys 
        275                 280                 285             

Phe Gly Glu Glu Tyr Ala Arg His Lys Met Gln Val Ala Ser Ala Glu 
    290                 295                 300                 

Glu Ala Arg 
305         

<210>   519
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   519
Met Gly Glu Arg Arg Gly Phe Gly Leu Lys Lys Leu Ser Ala Ala Ile 
                5                   10                  15      

Val Gly Ser Gly Asn Ile Gly Thr Asp Leu Met Ile Lys Leu Lys Arg 
            20                  25                  30          

Ser Pro Trp Ile Glu Pro Arg Trp Met Ile Gly Ile Asp Pro Glu Ser 
        35                  40                  45              

Asp Gly Leu Arg Arg Ala Arg Glu Met Gly Leu Glu Thr Ser Ala Asp 
    50                  55                  60                  

Gly Leu Lys Ala Val Leu Glu Gln Gly Val Arg Pro Asp Ile Val Phe 
65                  70                  75                  80  

Asp Ala Thr Ser Ala Lys Ala His Val Arg His Ala Lys Leu Leu Arg 
                85                  90                  95      

Glu Ala Gly Ile Gln Ala Val Asp Leu Thr Pro Ala Ala Arg Gly Pro 
            100                 105                 110         

Tyr Val Ile Ala Ala Val Asn Leu Glu Glu His Leu Asp Ser Pro Asn 
        115                 120                 125             

Val Asn Met Val Thr Cys Gly Gly Gln Ala Thr Val Pro Met Val Tyr 
    130                 135                 140                 

Ala Val Ser Arg Val Val Gly Val Arg Tyr Ala Glu Ile Val Ala Thr 
145                 150                 155                 160 

Ile Ala Ser Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu 
                165                 170                 175     

Phe Thr Gln Thr Thr Ala Arg Ala Leu Glu Ala Ile Gly Gly Ala Lys 
            180                 185                 190         

Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro Ala Glu Pro Pro Ile Leu 
        195                 200                 205             

Met Arg Asp Thr Ile Tyr Cys Ile Met Glu Asp Ala Ser Pro Thr Thr 
    210                 215                 220                 

Gln Ala Lys Val Leu Glu Ser Ile Glu Gln Met Val Arg His Val Gln 
225                 230                 235                 240 

Thr Phe Val Pro Gly Tyr Arg Leu Asn Arg Glu Pro Ile Phe Gln Asp 
                245                 250                 255     

Asp Leu Val Ser Ile Ser Ile Glu Val Glu Gly Leu Gly Asp Tyr Leu 
            260                 265                 270         

Pro Val Tyr Ala Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Val Lys 
        275                 280                 285             

Phe Gly Glu Glu Tyr Ala Arg His Lys Met Gln Val Ala Ser Ala Glu 
    290                 295                 300                 

Glu Ala Arg 
305         

<210>   520
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   520
Met Gly Glu Arg Arg Gly Phe Gly Leu Lys Lys Leu Ser Ala Ala Ile 
                5                   10                  15      

Val Gly Ser Gly Asn Ile Gly Thr Asp Leu Met Ile Lys Leu Lys Arg 
            20                  25                  30          

Ser Pro Trp Ile Glu Pro Arg Trp Met Ile Gly Ile Asp Pro Glu Ser 
        35                  40                  45              

Asp Gly Leu Arg Arg Ala Arg Glu Met Gly Leu Glu Thr Ser Ala Asp 
    50                  55                  60                  

Gly Leu Lys Ala Val Leu Glu Gln Gly Val Arg Pro Asp Ile Val Phe 
65                  70                  75                  80  

Asp Ala Thr Ser Ala Lys Ala His Val Arg His Ala Lys Leu Leu Arg 
                85                  90                  95      

Asp Ala Gly Ile Gln Ala Val Asp Leu Thr Pro Ala Ala Arg Gly Pro 
            100                 105                 110         

Tyr Val Ile Ala Ala Val Asn Leu Glu Glu His Leu Asp Ser Pro Asn 
        115                 120                 125             

Val Asn Met Val Thr Cys Gly Gly Gln Ala Thr Val Pro Met Val Tyr 
    130                 135                 140                 

Ala Val Ser Arg Val Val Gly Val Arg Tyr Ala Glu Ile Val Ala Thr 
145                 150                 155                 160 

Ile Ala Ser Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu 
                165                 170                 175     

Phe Thr Gln Thr Thr Ala Arg Ala Leu Glu Ala Ile Gly Gly Ala Lys 
            180                 185                 190         

Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro Ala Glu Pro Pro Ile Leu 
        195                 200                 205             

Met Arg Asp Thr Ile Tyr Cys Leu Met Glu Asp Ala Ser Pro Thr Thr 
    210                 215                 220                 

Gln Ala Lys Val Leu Glu Ser Ile Glu Gln Met Val Arg His Val Gln 
225                 230                 235                 240 

Thr Phe Val Pro Gly Tyr Arg Leu Asn Arg Glu Pro Ile Phe Gln Asp 
                245                 250                 255     

Asp Leu Val Ser Ile Ser Ile Glu Val Glu Gly Leu Gly Asp Tyr Leu 
            260                 265                 270         

Pro Val Tyr Ala Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Val Lys 
        275                 280                 285             

Phe Gly Glu Glu Tyr Ala Arg His Lys Met Gln Val Ala Ser Ala Glu 
    290                 295                 300                 

Glu Ala Arg 
305         

<210>   521
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   521
Met Gly Glu Arg Arg Gly Phe Gly Leu Lys Lys Leu Ser Ala Ala Ile 
                5                   10                  15      

Val Gly Ser Gly Asn Ile Gly Thr Asp Leu Met Ile Lys Leu Lys Arg 
            20                  25                  30          

Ser Pro Trp Ile Glu Pro Arg Trp Met Ile Gly Ile Asp Pro Glu Ser 
        35                  40                  45              

Asp Gly Leu Arg Arg Ala Arg Glu Met Gly Leu Glu Thr Ser Ala Asp 
    50                  55                  60                  

Gly Leu Lys Ala Val Leu Glu Gln Gly Val Arg Pro Asp Ile Val Phe 
65                  70                  75                  80  

Asp Ala Thr Ser Ala Lys Ala His Val Arg His Ala Lys Leu Leu Arg 
                85                  90                  95      

Glu Ala Gly Ile Gln Ala Val Asp Leu Thr Pro Ala Ala Arg Gly Pro 
            100                 105                 110         

Tyr Val Ile Ala Ala Val Asn Leu Glu Glu His Leu Asp Ser Pro Asn 
        115                 120                 125             

Val Asn Met Val Thr Cys Gly Gly Gln Ala Thr Val Pro Met Val Tyr 
    130                 135                 140                 

Ala Val Ser Arg Val Val Gly Val Arg Tyr Ala Glu Ile Val Ala Thr 
145                 150                 155                 160 

Ile Ala Ser Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu 
                165                 170                 175     

Phe Thr Gln Thr Thr Ala Arg Ala Leu Glu Ala Ile Gly Gly Ala Lys 
            180                 185                 190         

Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro Ala Glu Pro Pro Ile Leu 
        195                 200                 205             

Met Arg Asp Thr Ile Tyr Cys Leu Met Glu Asp Ala Ser Pro Thr Thr 
    210                 215                 220                 

Gln Ala Lys Val Leu Glu Ser Ile Glu Gln Met Val Lys His Val Gln 
225                 230                 235                 240 

Thr Phe Val Pro Gly Tyr Arg Leu Asn Arg Glu Pro Ile Phe Gln Asp 
                245                 250                 255     

Asp Leu Val Ser Ile Ser Ile Glu Val Glu Gly Leu Gly Asp Tyr Leu 
            260                 265                 270         

Pro Val Tyr Ala Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Val Lys 
        275                 280                 285             

Phe Gly Glu Glu Tyr Ala Arg His Lys Met Gln Val Ala Ser Ala Glu 
    290                 295                 300                 

Glu Ala Arg 
305         

<210>   522
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   522
Met Gly Glu Arg Arg Gly Phe Gly Leu Lys Lys Leu Ser Ala Ala Ile 
                5                   10                  15      

Val Gly Ser Gly Asn Ile Gly Thr Asp Leu Met Ile Lys Leu Lys Arg 
            20                  25                  30          

Ser Pro Trp Ile Glu Pro Arg Trp Met Ile Gly Ile Asp Pro Glu Ser 
        35                  40                  45              

Asp Gly Leu Arg Arg Ala Arg Glu Met Gly Leu Glu Thr Ser Ala Asp 
    50                  55                  60                  

Gly Leu Lys Ala Val Leu Glu Gln Gly Val Arg Pro Asp Ile Val Phe 
65                  70                  75                  80  

Asp Ala Thr Ser Ala Lys Ala His Val Arg His Ala Lys Leu Leu Arg 
                85                  90                  95      

Glu Ala Gly Ile Gln Ala Val Asp Leu Thr Pro Ala Ala Arg Gly Pro 
            100                 105                 110         

Tyr Val Ile Ala Ala Val Asn Leu Glu Glu His Leu Asp Ser Pro Asn 
        115                 120                 125             

Val Asn Met Val Thr Cys Gly Gly Gln Ala Thr Val Pro Met Val Tyr 
    130                 135                 140                 

Ala Val Ser Arg Val Val Gly Val Arg Tyr Ala Glu Ile Val Ala Thr 
145                 150                 155                 160 

Ile Ala Ser Arg Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu 
                165                 170                 175     

Phe Thr Gln Thr Thr Ala Arg Ala Leu Glu Ala Ile Gly Gly Ala Lys 
            180                 185                 190         

Arg Gly Lys Ala Ile Ile Ile Leu Asn Pro Ala Glu Pro Pro Ile Leu 
        195                 200                 205             

Met Arg Asp Thr Ile Tyr Cys Leu Met Glu Asp Ala Ser Pro Thr Thr 
    210                 215                 220                 

Gln Ala Lys Val Leu Glu Ser Ile Glu Gln Met Val Arg His Val Gln 
225                 230                 235                 240 

Thr Phe Val Pro Gly Tyr Arg Leu Asn Arg Glu Pro Ile Phe Gln Asp 
                245                 250                 255     

Asp Leu Val Ser Ile Ser Ile Glu Val Glu Gly Leu Gly Asp Tyr Leu 
            260                 265                 270         

Pro Val Tyr Ala Gly Asn Leu Asp Ile Met Thr Ala Ala Ala Val Lys 
        275                 280                 285             

Phe Gly Glu Glu Tyr Ala Arg His Lys Met Gln Val Ala Ser Ala Glu 
    290                 295                 300                 

Glu Ala Arg 
305         

<210>   523
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   523
gtgggcgata ggagagggtt cggattgaag aagctcagtg ccgcgatcgt cgggtccgga       60

aacatcggga cggatctcat gatcaagctg aagcgaagcc cgtggattga accgcgctgg      120

atgatcggca tcgacccgga atcggatggc cttcggcgcg cgcgcgagat ggggcttgag      180

acgtcggccg acggactcaa ggcggtcctc gaacaagggg tgcgcccgga catcgtcttt      240

gacgcgacga gcgcgaaggc gcacgtgcgc catgccaaac tgcttcgcga agcaggcatc      300

caggcggtcg acttgacgcc ggcagcgcgc gggccgtacg tcatcgcggc ggtcaacctg      360

gaggagcacc tcgactcgcc gaacgttaac atggtcacct gcggcggcca ggccaccgtg      420

ccgatggtgt acgccgtcag ccgggtggtc ggggtgcgtt acgcggagat tgtcgccacc      480

atcgccagca agagcgcggg ccccggcacg cgggcgaaca tcgacgagtt cacccagacg      540

acggcgcgcg cgctggaggc catcggaggc gcaaagcgag ggaaggccat catcatcctc      600

aacccggcgg aaccccccat cctcatgcgc gacaccatct actgcttgat ggaagacgcg      660

agcccgacca cccaggcgaa ggtgctcgag tccatcgaac agatggtgcg ccacgtgcag      720

acattcgtcc ctgggtatcg gttgaaccgc gagcccatct tccaggacga tctcgtcagc      780

atctccatcg aggtcgaggg cctcggcgat tacctgccgg tgtacgcggg gaacctcgac      840

atcatgaccg cggcggcagt gaagtttggc gaagagtacg cgcgtcacaa gatgcaggtg      900

gcgtcggcgg aagaagcgag gtga                                             924


<210>   524
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   524
gtgggcgaaa ggagagggtt cggattgaag aagctcagtg ccgcgatcgt cgggtccgga       60

aacatcggga cggatctcat gatcaagctg aagcgaagcc cgtggattga accgcgctgg      120

atgatcggca tcgacccgga atcggatggc cttcggcgcg cgcgcgagat ggggcttgag      180

acgtcggccg acggactcaa ggcggtcctc gaacaagggg tgcgcccgga catcgtcttt      240

gacgcgacga gcgcgaaggc gcacgtgcgc catgccaaac tgcttcgcga agcaggcatc      300

caggcggtcg acttgacgcc ggcagcgcgc gggccgtacg tcatcgcggc ggtcaacctg      360

gaggagcacc tcgactcgcc gaacgttaac atggtcacct gcggcggcca ggccaccgtg      420

ccgatggtgt acgccgtcag ccgggtggtc ggggtgcgtt acgcggagat tgtcgccacc      480

atcgccagca agagcgcggg ccccggcacg cgggcgaaca tcgacgagtt cacccagacg      540

acggcgcgcg cgctggaggc catcggaggc gcaaagcgag ggaaggccat catcatcctc      600

aacccggcgg aaccccccat cctcatgcgc gacaccatct actgcattat ggaagacgcg      660

agcccgacca cccaggcgaa ggtgctcgag tccatcgaac agatggtgcg ccacgtgcag      720

acattcgtcc ctgggtatcg gttgaaccgc gagcccatct tccaggacga tctcgtcagc      780

atctccatcg aggtcgaggg cctcggcgat tacctgccgg tgtacgcggg gaacctcgac      840

atcatgaccg cggcggcagt gaagtttggc gaagagtacg cgcgtcacaa gatgcaggtg      900

gcgtcggcgg aagaagcgag gtga                                             924


<210>   525
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   525
gtgggcgaaa ggagagggtt cggattgaag aagctcagtg ccgcgatcgt cgggtccgga       60

aacatcggga cggatctcat gatcaagctg aagcgaagcc cgtggattga accgcgctgg      120

atgatcggca tcgacccgga atcggatggc cttcggcgcg cgcgcgagat ggggcttgag      180

acgtcggccg acggactcaa ggcggtcctc gaacaagggg tgcgcccgga catcgtcttt      240

gacgcgacga gcgcgaaggc gcacgtgcgc catgccaaac tgcttcgcga tgcaggcatc      300

caggcggtcg acttgacgcc ggcagcgcgc gggccgtacg tcatcgcggc ggtcaacctg      360

gaggagcacc tcgactcgcc gaacgttaac atggtcacct gcggcggcca ggccaccgtg      420

ccgatggtgt acgccgtcag ccgggtggtc ggggtgcgtt acgcggagat tgtcgccacc      480

atcgccagca agagcgcggg ccccggcacg cgggcgaaca tcgacgagtt cacccagacg      540

acggcgcgcg cgctggaggc catcggaggc gcaaagcgag ggaaggccat catcatcctc      600

aacccggcgg aaccccccat cctcatgcgc gacaccatct actgcttgat ggaagacgcg      660

agcccgacca cccaggcgaa ggtgctcgag tccatcgaac agatggtgcg ccacgtgcag      720

acattcgtcc ctgggtatcg gttgaaccgc gagcccatct tccaggacga tctcgtcagc      780

atctccatcg aggtcgaggg cctcggcgat tacctgccgg tgtacgcggg gaacctcgac      840

atcatgaccg cggcggcagt gaagtttggc gaagagtacg cgcgtcacaa gatgcaggtg      900

gcgtcggcgg aagaagcgag gtga                                             924


<210>   526
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   526
gtgggcgaaa ggagagggtt cggattgaag aagctcagtg ccgcgatcgt cgggtccgga       60

aacatcggga cggatctcat gatcaagctg aagcgaagcc cgtggattga accgcgctgg      120

atgatcggca tcgacccgga atcggatggc cttcggcgcg cgcgcgagat ggggcttgag      180

acgtcggccg acggactcaa ggcggtcctc gaacaagggg tgcgcccgga catcgtcttt      240

gacgcgacga gcgcgaaggc gcacgtgcgc catgccaaac tgcttcgcga agcaggcatc      300

caggcggtcg acttgacgcc ggcagcgcgc gggccgtacg tcatcgcggc ggtcaacctg      360

gaggagcacc tcgactcgcc gaacgttaac atggtcacct gcggcggcca ggccaccgtg      420

ccgatggtgt acgccgtcag ccgggtggtc ggggtgcgtt acgcggagat tgtcgccacc      480

atcgccagca agagcgcggg ccccggcacg cgggcgaaca tcgacgagtt cacccagacg      540

acggcgcgcg cgctggaggc catcggaggc gcaaagcgag ggaaggccat catcatcctc      600

aacccggcgg aaccccccat cctcatgcgc gacaccatct actgcttgat ggaagacgcg      660

agcccgacca cccaggcgaa ggtgctcgag tccatcgaac agatggtgaa acacgtgcag      720

acattcgtcc ctgggtatcg gttgaaccgc gagcccatct tccaggacga tctcgtcagc      780

atctccatcg aggtcgaggg cctcggcgat tacctgccgg tgtacgcggg gaacctcgac      840

atcatgaccg cggcggcagt gaagtttggc gaagagtacg cgcgtcacaa gatgcaggtg      900

gcgtcggcgg aagaagcgag gtga                                             924


<210>   527
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   527
gtgggcgaaa ggagagggtt cggattgaag aagctcagtg ccgcgatcgt cgggtccgga       60

aacatcggga cggatctcat gatcaagctg aagcgaagcc cgtggattga accgcgctgg      120

atgatcggca tcgacccgga atcggatggc cttcggcgcg cgcgcgagat ggggcttgag      180

acgtcggccg acggactcaa ggcggtcctc gaacaagggg tgcgcccgga catcgtcttt      240

gacgcgacga gcgcgaaggc gcacgtgcgc catgccaaac tgcttcgcga agcaggcatc      300

caggcggtcg acttgacgcc ggcagcgcgc gggccgtacg tcatcgcggc ggtcaacctg      360

gaggagcacc tcgactcgcc gaacgttaac atggtcacct gcggcggcca ggccaccgtg      420

ccgatggtgt acgccgtcag ccgggtggtc ggggtgcgtt acgcggagat tgtcgccacc      480

atcgccagcc gtagcgcggg ccccggcacg cgggcgaaca tcgacgagtt cacccagacg      540

acggcgcgcg cgctggaggc catcggaggc gcaaagcgag ggaaggccat catcatcctc      600

aacccggcgg aaccccccat cctcatgcgc gacaccatct actgcttgat ggaagacgcg      660

agcccgacca cccaggcgaa ggtgctcgag tccatcgaac agatggtgcg ccacgtgcag      720

acattcgtcc ctgggtatcg gttgaaccgc gagcccatct tccaggacga tctcgtcagc      780

atctccatcg aggtcgaggg cctcggcgat tacctgccgg tgtacgcggg gaacctcgac      840

atcatgaccg cggcggcagt gaagtttggc gaagagtacg cgcgtcacaa gatgcaggtg      900

gcgtcggcgg aagaagcgag gtga                                             924


<210>   528
<211>   927
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   528
Met Ser His Gly Glu Leu Ala Ala Ser Ala Arg Arg Pro Met Cys Lys 
                5                   10                  15      

Arg Phe Ala Gly Trp Ala Thr Arg Arg Pro Arg Gln Gly Gly Cys Lys 
            20                  25                  30          

Met Ala Gln Val Gln Asp Val Gln Arg Asp Gln Ala Leu Thr Thr Arg 
        35                  40                  45              

Trp Val Tyr Ser Phe Asp Gln Ala Asp Pro Lys Asn Arg Ser Leu Leu 
    50                  55                  60                  

Gly Gly Lys Gly Ala Asn Leu Ala Gln Met Val Gln Trp Gly Phe Pro 
65                  70                  75                  80  

Val Pro Pro Gly Phe Thr Ile Thr Thr Glu Ala Cys Asn Glu Tyr Trp 
                85                  90                  95      

Ala Arg Gly Gly Lys Phe Pro Glu Gly Leu Leu Asp Glu Val Ala Leu 
            100                 105                 110         

Ala Ile Leu Arg Leu Glu Arg Thr Ala Gly Lys Arg Phe Gly Asp Ala 
        115                 120                 125             

Phe Gln Pro Leu Leu Val Ser Val Arg Ser Gly Ala Pro Val Ser Met 
    130                 135                 140                 

Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu Asn Asp Leu Thr 
145                 150                 155                 160 

Val Arg Ala Leu Ala Asn Gln Ser Gln Asp Pro Ala Phe Ala Tyr Asp 
                165                 170                 175     

Ser Tyr Arg Arg Leu Ile Gln Met Phe Ala Asn Val Val Phe Asn Val 
            180                 185                 190         

Ser Leu Glu Pro Phe Glu His Ala Leu Arg Ala Ala Lys Ala Lys His 
        195                 200                 205             

Gly Val Glu Arg Asp Arg Asp Leu Pro Ala Asp Ala Trp Lys Asp Leu 
    210                 215                 220                 

Val Ala Thr Tyr Leu Lys Leu Phe Ala Glu His Val Gly Gln Pro Phe 
225                 230                 235                 240 

Pro Gln Asp Val Asn Val Gln Leu Glu Leu Ala Ile Glu Ala Val Phe 
                245                 250                 255     

Arg Ser Trp Asn Ser Pro Arg Ala Ile Val Tyr Arg Lys Ala His Gly 
            260                 265                 270         

Ile Pro Glu Thr Leu Gly Thr Ala Val Asn Val Gln Ala Met Val Phe 
        275                 280                 285             

Gly Asn Met Gly Asp Asp Ser Gly Thr Gly Val Ile Phe Thr Arg His 
    290                 295                 300                 

Pro Ser Thr Gly Glu Pro Val Leu Phe Gly Glu Phe Leu Ala Asn Ala 
305                 310                 315                 320 

Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Gln Pro Ile Ala 
                325                 330                 335     

Asp Leu Ala His Thr Met Pro His Val Tyr Glu Ser Leu Val Ala Leu 
            340                 345                 350         

Ala Lys Gln Leu Glu Thr Arg Phe Arg Asp Met Gln Asp Val Glu Phe 
        355                 360                 365             

Thr Val Glu Arg Gly Lys Leu Phe Val Leu Gln Thr Arg Ser Gly Lys 
    370                 375                 380                 

Arg Thr Ala Gln Ala Ala Val Arg Ile Ala Ile Asp Met Leu His Glu 
385                 390                 395                 400 

Gly Leu Ile Gln Pro Glu Glu Ala Leu Leu Arg Val Asp Ala Gln His 
                405                 410                 415     

Leu Arg Gln Leu Leu His Arg Arg Leu Gln Gly Thr Asp Ala Leu Gln 
            420                 425                 430         

Val Phe Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ser Val Gly Arg 
        435                 440                 445             

Ile Val Leu Asp Ala Asp Thr Ala Val Glu Trp Ala Gln Arg Gly Glu 
    450                 455                 460                 

Lys Val Val Leu Val Arg Pro Glu Thr Thr Pro Glu Asp Ile His Gly 
465                 470                 475                 480 

Val Leu Ala Ala Glu Gly Val Val Thr Thr His Gly Gly Met Thr Ser 
                485                 490                 495     

His Ala Ala Val Val Ala Arg Gly Ile Gly Lys Pro Ala Val Cys Gly 
            500                 505                 510         

Cys Asp Gly Val His Ile Asp Phe Glu Ala Arg Gln Val Glu Ser Asn 
        515                 520                 525             

Gly Val Val Leu Lys Glu Gly Asp Val Ile Ser Val Asp Gly Gly Thr 
    530                 535                 540                 

Gly Thr Val Tyr Val Gly Glu Ala Gln Met Glu Glu Ala Lys Met Ala 
545                 550                 555                 560 

Asp Glu Leu Lys Glu Leu Leu Ser Ile Ala Asp Gln Val Arg Arg Leu 
                565                 570                 575     

Lys Val Arg Ala Asn Ala Asp Thr Pro Glu Asp Ala Arg Arg Ala Arg 
            580                 585                 590         

Glu Phe Gly Ala Glu Gly Ile Gly Leu Cys Arg Thr Glu His Met Phe 
        595                 600                 605             

Leu Ser Pro Asp Arg Val Pro Leu Val Gln Arg Met Ile Leu Ala Thr 
    610                 615                 620                 

Thr Ser Ala Glu Arg Gln Ala Ala Leu Ser Lys Leu Leu Pro Leu Gln 
625                 630                 635                 640 

Val Ser Asp Phe Thr Ala Ile Phe Glu Ala Met Asp Gly Leu Pro Val 
                645                 650                 655     

Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu Pro Arg Glu 
            660                 665                 670         

Glu Glu Leu Ala Glu Arg Leu Glu Glu Leu Arg Ala Gln Gly Ala Ser 
        675                 680                 685             

Glu Asp Glu Ile Ala Glu Thr Glu Gln Leu Leu Arg Gln Ala Arg Tyr 
    690                 695                 700                 

Leu Arg Glu Ala Asn Pro Met Met Gly Leu Arg Gly Ser Arg Leu Gly 
705                 710                 715                 720 

Ile Val Tyr Pro Glu Ile Tyr Asp Met Gln Met Glu Ala Ile Ile Thr 
                725                 730                 735     

Ala Ala Ala Gln Ala Lys Arg Arg Gly Ile Ala Val Asp Leu Glu Val 
            740                 745                 750         

Met Leu Pro Leu Ile Gly Ser Pro Lys Glu Leu Arg Val Leu Arg Glu 
        755                 760                 765             

Arg Met Glu Glu Ile Ala Lys Arg Thr Met Glu Arg Glu Gly Val Glu 
    770                 775                 780                 

Ile Glu Tyr Arg Ile Gly Thr Met Ile Glu Val Pro Arg Ala Ala Leu 
785                 790                 795                 800 

Thr Ala Asp Gln Ile Ala Glu Asp Ala Gln Phe Phe Ser Phe Gly Thr 
                805                 810                 815     

Asn Asp Leu Thr Gln Met Thr Phe Ala Phe Ser Arg Asp Asp Ala Glu 
            820                 825                 830         

Gly Lys Phe Leu Asn Val Tyr Leu Asp Arg Glu Ile Leu Pro Tyr Asn 
        835                 840                 845             

Pro Phe Glu Thr Leu Asp Thr Glu Gly Val Gly Lys Leu Ile Gln Trp 
    850                 855                 860                 

Ala Val Glu Ala Gly Arg Lys Arg Arg Pro Asp Leu Lys Thr Gly Val 
865                 870                 875                 880 

Cys Gly Glu His Gly Gly Asp Pro Ala Ser Ile Ala Phe Cys Glu Asp 
                885                 890                 895     

Ile Gly Leu Asp Tyr Val Ser Cys Ser Pro Phe Arg Ile Pro Val Ala 
            900                 905                 910         

Arg Ile Ala Ala Ala Gln Ala Ala Val Arg Lys Arg Met Thr Gly 
        915                 920                 925         

<210>   529
<211>   2784
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   529
gtgtcacatg gcgagctcgc ggcaagcgca cggcgaccca tgtgcaagcg cttcgccgga       60

tgggcgacac gaaggccgcg acaaggggga tgcaagatgg cgcaggtgca ggatgtacag      120

cgcgatcagg cgctcacgac ccggtgggtc tattcctttg atcaagcaga tccgaaaaac      180

cgaagccttt tgggcggcaa aggcgccaac ttggcgcaga tggttcaatg ggggtttccc      240

gtcccgcctg gctttaccat cacgacggag gcttgcaacg aatattgggc gcggggcggc      300

aagtttcccg aagggctgct ggacgaggtg gcgctcgcca tcctgcggct cgagcgcacg      360

gccgggaagc gattcggcga cgcgtttcag ccgctccttg tttccgtgcg ctccggcgcg      420

cccgtgtcga tgccgggcat gatggacacc attttgaatc tgggcctcaa tgatctgacg      480

gtgcgggcgc tggcgaatca gtcgcaggat cccgcgttcg cctacgactc gtaccgccgc      540

ctgattcaaa tgttcgcaaa cgtggtgttc aacgtatcgc tggagccgtt cgaacacgcg      600

cttagggcgg cgaaggccaa gcacggcgtt gagcgcgatc gcgaccttcc ggccgacgcg      660

tggaaggatc tcgtggcgac gtacctgaaa ctgtttgcag aacacgtcgg acagccgttc      720

ccgcaggacg tgaacgtgca attggaactc gccatcgagg ccgtgttccg ctcgtggaac      780

agcccgcggg ccatcgtcta tcgcaaggct cacggtatcc ctgagaccct cggcacagcg      840

gtcaacgttc aggccatggt gtttggcaac atgggcgacg acagcggcac gggcgtgatc      900

ttcacgcgcc atccgtcgac gggcgagccc gtcttgttcg gcgagttctt ggccaacgct      960

cagggcgagg acgtggtcgc gggcattcgc acgcctcaac ccattgccga tctcgcccac     1020

accatgccgc acgtgtacga gtcgcttgtg gccctcgcga aacagttgga gacgcgcttc     1080

cgggacatgc aggacgtcga gttcacggtg gagcggggca agctgttcgt gctgcagacg     1140

cggagcggga agcgcacggc gcaggcggcc gtccgcatcg ccatcgacat gctgcatgaa     1200

ggcctgattc agccggaaga ggcgctcctg cgcgtcgacg cccagcatct gcgccagctt     1260

ttgcaccggc ggctgcaggg aacggatgca ctgcaggtgt tcgccaaggg gcttccggcg     1320

tctccaggcg cgagcgtggg ccgaattgtg ttggatgcgg acacggcggt ggagtgggcg     1380

cagcgcggcg agaaggtcgt cctcgtgagg cctgagacga cgcccgagga catccacggc     1440

gtgctggccg cggaaggcgt tgtgacgacg cacggtggga tgacgagcca cgcggcggtt     1500

gtggcccgcg gaattggcaa gccggcggtc tgcggctgtg acggcgtgca catcgacttc     1560

gaggcgcgtc aggtcgaatc gaacggcgtc gtgctgaagg aaggtgacgt catctcggtg     1620

gacggcggaa ccgggacggt gtatgtcgga gaggcgcaga tggaagaagc gaaaatggcg     1680

gacgagctga aggagttgct gtccatcgcg gaccaagtgc ggcgcctcaa ggtccgcgcc     1740

aacgcggaca cgccggaaga cgcgcggcgc gcgcgagagt tcggcgctga gggcattggc     1800

ctgtgccgca cggaacacat gttcctgtcg ccggatcggg tgccgctcgt gcagcgcatg     1860

attttggcga ccacgtcggc tgagcgacag gcggccctgt cgaaactgct gccgctccag     1920

gtctcggatt tcaccgccat cttcgaagcg atggacggcc tgccggtgac catacgtctg     1980

ctggatccgc cgctgcacga gttcctgccg cgcgaagagg agctggccga acgcctcgag     2040

gagcttcgcg cgcagggcgc gtccgaggac gagatcgccg agacggaaca gttgctccgg     2100

caagcccgat acctgcggga ggccaacccc atgatgggtc tccgaggttc tcggttgggc     2160

atcgtgtacc ctgagatcta cgatatgcag atggaggcca tcatcacggc cgcggcgcag     2220

gcgaaacgcc gaggcatcgc cgtcgacctg gaagtgatgt tgccgctcat cggctctccg     2280

aaggaacttc gcgttttgcg cgagcgcatg gaggagatcg ctaagcggac gatggagcgc     2340

gagggcgtcg agatcgaata ccgcatcggc acgatgatcg aggtgccgcg cgccgcgctg     2400

acggcggacc agattgcgga ggatgcgcag ttcttctcct tcggcaccaa cgacctgacg     2460

cagatgacgt tcgccttcag ccgagacgac gccgagggga aattcctcaa cgtatacctg     2520

gatcgggaga tcttgcctta caacccgttc gagacgctgg atacggaggg cgtcggcaag     2580

ctgattcaat gggcagtcga agcggggcgc aagcgccgtc ccgatttgaa gaccggcgtg     2640

tgcggcgaac acgggggcga tccggcgtcg attgcgttct gcgaggacat tgggctcgac     2700

tacgtcagct gctcgccctt ccgcatcccg gtcgcgcgga ttgccgcggc gcaggcggcc     2760

gtgcgcaaac gcatgacggg ttga                                            2784


<210>   530
<211>   861
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   530
Thr Lys Tyr Val Tyr Leu Phe His Glu Gly Arg Ala Asp Met Lys Asp 
                5                   10                  15      

Leu Leu Gly Gly Lys Gly Ala Asn Leu Ala Glu Met Thr Asn Ile Gly 
            20                  25                  30          

Leu Pro Val Pro Pro Gly Met Thr Ile Thr Thr Glu Ala Cys Arg Glu 
        35                  40                  45              

Tyr Tyr Arg Leu Gly Gly Lys Phe Pro Glu Gly Leu Met Glu Glu Val 
    50                  55                  60                  

Lys Glu Lys Leu Val Tyr Ile Glu Glu Lys Thr Gly Lys Lys Phe Gly 
65                  70                  75                  80  

Asp Pro Gln Asn Pro Leu Leu Val Ser Val Arg Ser Gly Ala Lys Phe 
                85                  90                  95      

Ser Met Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu Asn Glu 
            100                 105                 110         

Glu Thr Val Glu Gly Leu Ala Gln Asn Thr Gln Asn Pro Arg Phe Ala 
        115                 120                 125             

Tyr Asp Ala Tyr Arg Arg Phe Ile Gln Met Phe Gly Asp Val Val Leu 
    130                 135                 140                 

Glu Ile Pro Lys His Glu Phe Glu His Ile Leu Asp Arg Gln Lys Glu 
145                 150                 155                 160 

Lys Glu Gly Val Thr Phe Asp Gln Glu Leu Ser Ala Glu Ala Leu Lys 
                165                 170                 175     

Glu Val Ile Thr Arg Tyr Lys Glu Leu Val Glu Arg Lys Thr Gly Lys 
            180                 185                 190         

Pro Phe Pro Ser Asp Pro Met Val Gln Leu Thr Met Ala Ile Glu Ala 
        195                 200                 205             

Val Phe Lys Ser Trp Asn Asn Asp Arg Ala Ile Val Tyr Arg Asn Leu 
    210                 215                 220                 

Asn Lys Ile Pro His Asp Leu Gly Thr Ala Val Asn Ile Gln Ser Met 
225                 230                 235                 240 

Val Phe Gly Asn Met Gly Asn Asp Ser Gly Thr Gly Val Ala Phe Thr 
                245                 250                 255     

Arg Asn Pro Ser Thr Gly Glu Lys Val Leu Tyr Gly Glu Tyr Leu Thr 
            260                 265                 270         

Asn Ala Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Ser Pro 
        275                 280                 285             

Ile Ser Lys Leu Lys Glu Glu Met Pro Glu Val Tyr Glu Gln Phe Val 
    290                 295                 300                 

Ser Ile Ala Lys Leu Leu Glu Ser His Tyr Lys Asn Met Gln Asp Ile 
305                 310                 315                 320 

Glu Phe Thr Ile Glu Arg Gly Lys Leu Tyr Ile Leu Gln Thr Arg Asn 
                325                 330                 335     

Gly Lys Arg Thr Ala Gln Ala Ala Val Lys Ile Ala His Asp Met Val 
            340                 345                 350         

Glu Glu Gly Leu Ile Thr Lys Lys Glu Ala Ile Leu Met Val Glu Pro 
        355                 360                 365             

Gly Gln Leu Asp Gln Leu Leu His Arg Gln Ile Asp Pro Ser Ala Lys 
    370                 375                 380                 

Val Glu Val Ile Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ala Ser 
385                 390                 395                 400 

Gly Ile Val Val Phe Asp Ala Asp Glu Ala Glu Lys Leu Gly Lys Glu 
                405                 410                 415     

Gly Lys Lys Val Leu Leu Val Arg Thr Glu Thr Thr Pro Asp Asp Ile 
            420                 425                 430         

His Gly Ile Val Ala Ala Gln Gly Val Leu Thr Ser Arg Gly Gly Met 
        435                 440                 445             

Thr Ser His Ala Ala Val Val Ala Arg Gly Met Gly Lys Pro Cys Val 
    450                 455                 460                 

Cys Gly Cys Glu Ala Ile Lys Ile Asp Tyr Glu Lys Lys Leu Phe Thr 
465                 470                 475                 480 

Val Asp Asn Ile Thr Val Lys Glu Gly Asp Tyr Leu Ser Ile Asp Gly 
                485                 490                 495     

Ser Thr Gly Arg Val Ile Leu Gly Thr Val Pro Met Lys Asp Pro Glu 
            500                 505                 510         

Leu Ser Pro Glu Phe Ile Lys Leu Leu Glu Trp Ala Asp Glu Leu Lys 
        515                 520                 525             

Arg Leu Glu Val Arg Ala Asn Ala Asp Thr Pro Glu Asp Ala Gln Lys 
    530                 535                 540                 

Ala Arg Glu Phe Gly Ala Lys Gly Ile Gly Leu Cys Arg Thr Glu His 
545                 550                 555                 560 

Met Phe Met Gly Pro Glu Arg Leu Pro His Val Gln Arg Met Ile Leu 
                565                 570                 575     

Ala Glu Thr Lys Glu Glu Arg Glu Glu Ala Leu Ser His Leu Leu Pro 
            580                 585                 590         

Met Gln Glu Glu Asp Phe Tyr Gly Ile Leu Lys Ala Met Glu Gly Tyr 
        595                 600                 605             

Pro Val Cys Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu Pro 
    610                 615                 620                 

Ser Leu Glu Glu Leu Leu Val Glu Thr Thr Glu Leu Arg Val Arg Gly 
625                 630                 635                 640 

Asp Asn Pro Glu Leu Leu Ala Glu Lys Glu Ala Leu Leu Lys Lys Val 
                645                 650                 655     

Lys Ser Leu His Glu Phe Asn Pro Met Leu Gly His Arg Gly Cys Arg 
            660                 665                 670         

Leu Gly Ile Thr Tyr Pro Glu Val Tyr Glu Met Gln Ile Arg Ala Ile 
        675                 680                 685             

Phe Asn Ala Ala Ala Arg Leu Thr Lys Glu Gly Tyr Lys Val Tyr Pro 
    690                 695                 700                 

Glu Val Glu Ile Pro Leu Thr Ile Asp Val Asn Glu Met Lys Phe Phe 
705                 710                 715                 720 

Lys Glu Arg Ile Asp Ala Ile Ala Arg Glu Val Met Glu Arg Glu Gly 
                725                 730                 735     

Val Thr Phe His Tyr Thr Thr Gly Thr Met Ile Glu Leu Pro Arg Ala 
            740                 745                 750         

Ala Leu Leu Ala Asp Glu Leu Ala Glu Val Ala Glu Phe Phe Ser Phe 
        755                 760                 765             

Gly Thr Asn Asp Leu Thr Gln Thr Thr Leu Gly Phe Ser Arg Asp Asp 
    770                 775                 780                 

Ala Glu Gly Lys Phe Leu Thr His Tyr Leu Asp Met Lys Ile Leu Lys 
785                 790                 795                 800 

Glu Asn Pro Phe Ile Val Leu Asp Arg Lys Gly Val Gly Lys Leu Met 
                805                 810                 815     

Lys Ile Ala Val Glu Gly Gly Arg Lys Thr Arg Pro Asp Leu Leu Val 
            820                 825                 830         

Gly Ile Cys Gly Glu His Gly Gly Glu Pro Ser Ser Val Glu Phe Cys 
        835                 840                 845             

His Gln Ile Gly Leu Asp Phe Val Ser Cys Ser Pro Tyr 
    850                 855                 860     

<210>   531
<211>   861
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   531
Thr Lys Phe Val Tyr Leu Phe Asn Glu Gly Asn Ser His Met Arg Asp 
                5                   10                  15      

Leu Leu Gly Gly Lys Gly Ala Asn Leu Ala Glu Met Thr Asn Ile Gly 
            20                  25                  30          

Leu Pro Val Pro Phe Gly Phe Thr Ile Thr Thr Glu Ala Cys Asn Asp 
        35                  40                  45              

Tyr Tyr Ser Asn Gly Lys Lys Ile Ser Asp Ala Val Glu Thr Gln Met 
    50                  55                  60                  

Glu Glu Ala Leu Leu Lys Leu Glu Glu Lys Thr Gly Lys Lys Leu Gly 
65                  70                  75                  80  

Gly Asn Glu Asn Pro Leu Leu Val Ser Val Arg Ser Gly Ser Val Phe 
                85                  90                  95      

Ser Met Pro Gly Met Met Asp Thr Val Leu Asn Leu Gly Met Asn Asp 
            100                 105                 110         

Glu Thr Val Glu Ala Val Ala Lys Leu Thr Gly Asn Pro Arg Phe Ala 
        115                 120                 125             

Tyr Asp Ser Tyr Arg Arg Phe Ile Gln Met Phe Ser Asp Val Val Leu 
    130                 135                 140                 

Gly Ile Glu Val Tyr His Phe Glu His Leu Leu Glu Gln Thr Arg Glu 
145                 150                 155                 160 

Gln Lys Gly Tyr Thr Ala Asp Pro Glu Met Thr Ala Glu Asp Trp Lys 
                165                 170                 175     

Asp Ile Ile Ala Gly Tyr Lys Lys Ile Val Lys Lys His Thr Lys Gln 
            180                 185                 190         

Asp Phe Pro Gln Asp Pro Lys Thr Gln Leu Tyr Leu Ala Val Asn Ala 
        195                 200                 205             

Val Phe Asp Ser Trp Asn Asn Gln Arg Ala Ile Val Tyr Arg Arg Leu 
    210                 215                 220                 

Asn Lys Ile Pro Asp His Leu Gly Thr Ala Val Asn Ile Gln Ser Met 
225                 230                 235                 240 

Val Phe Gly Asn Met Gly Asp Asp Ser Gly Thr Gly Val Ala Phe Thr 
                245                 250                 255     

Arg Asn Pro Ser Thr Gly Glu Arg Val Leu Tyr Gly Glu Tyr Leu Ile 
            260                 265                 270         

Asn Ala Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Gln Pro 
        275                 280                 285             

Ile Gln Val Leu Ala Lys Asp Met Pro Glu Val Tyr Arg Gln Phe Val 
    290                 295                 300                 

Lys Thr Ser Lys Leu Leu Glu Glu His Tyr Gln Asp Met Gln Asp Ile 
305                 310                 315                 320 

Glu Phe Thr Val Glu Arg Gly Lys Leu Tyr Leu Leu Gln Thr Arg Asn 
                325                 330                 335     

Gly Lys Arg Thr Ala Gln Ala Ala Ile Arg Ile Ala Val Glu Met Val 
            340                 345                 350         

Lys Glu Gly Ile Leu Asp Lys Lys Thr Ala Leu Leu Arg Val Asp Pro 
        355                 360                 365             

Asp Gln Met Asn Gln Leu Leu His Arg Arg Ile Asp Gly Ser Ala Thr 
    370                 375                 380                 

Lys Asn His Leu Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ala Thr 
385                 390                 395                 400 

Gly Thr Val Val Phe Asp Ala Asp Glu Ala Glu Arg Leu Gly Lys Glu 
                405                 410                 415     

Gly Glu Lys Val Ile Leu Val Arg Pro Glu Thr Thr Pro Asp Asp Ile 
            420                 425                 430         

His Gly Ile Val Ala Ser Gln Ala Val Val Thr Ser Arg Gly Gly Met 
        435                 440                 445             

Thr Ser His Ala Ala Val Val Ala Arg Gly Met Gly Lys Ala Cys Ile 
    450                 455                 460                 

Cys Gly Cys Glu Ser Met Lys Ile Asp Leu Lys Ala Lys Gln Phe Thr 
465                 470                 475                 480 

Val Gly Asp Thr Val Val Arg Tyr Gly Asp Val Ile Thr Ile Asp Gly 
                485                 490                 495     

Ser Thr Gly Glu Val Met Leu Gly Glu Val Pro Met Ile Asp Pro Glu 
            500                 505                 510         

Leu Ser Gly Glu Phe Lys Thr Leu Leu Glu Trp Ala Asp Glu Val Arg 
        515                 520                 525             

Asp Leu Gly Val Arg Ala Asn Ala Asp Asn Pro Thr Asp Ala Lys Lys 
    530                 535                 540                 

Ser Leu Glu Phe Gly Ala Asp Gly Ile Gly Leu Cys Arg Thr Glu His 
545                 550                 555                 560 

Met Phe Met Asp Ile Lys Arg Val Pro Ile Val Gln Glu Met Ile Leu 
                565                 570                 575     

Ala Glu Thr Leu Glu Glu Arg Glu Lys Ala Leu Asp Lys Leu Leu Pro 
            580                 585                 590         

Met Gln Gln Gly Asp Phe Glu Gly Ile Phe Glu Glu Met Ala Gly His 
        595                 600                 605             

Pro Val Thr Ile Arg Leu Leu Asp Pro Pro Met His Glu Phe Leu Pro 
    610                 615                 620                 

Asp Lys Glu Glu Leu Leu Val Glu Val Thr Lys Leu Gln Leu Thr Ala 
625                 630                 635                 640 

Pro Glu Ser Lys Glu Leu Glu Glu Lys Glu Tyr Leu Leu Lys Lys Val 
                645                 650                 655     

Gln His Leu Ala Glu Phe Asn Pro Met Leu Gly His Arg Gly Cys Arg 
            660                 665                 670         

Leu Gly Val Ile Phe Pro Glu Ile Tyr Glu Met Gln Val Lys Ala Ile 
        675                 680                 685             

Phe Tyr Ala Ala Ala Ala Val Leu Gln Lys Gly Ile Lys Val Gln Pro 
    690                 695                 700                 

Glu Ile Met Ile Pro Leu Val Gly His Val Asn Glu Leu Lys Arg Met 
705                 710                 715                 720 

Arg Ala Leu Val Thr Asp Met Ala Asn Gln Val Met Glu Glu Lys Gly 
                725                 730                 735     

Leu Lys Phe Asp Tyr Thr Val Gly Thr Met Ile Glu Ile Pro Arg Ala 
            740                 745                 750         

Ala Leu Thr Ala Asp Gln Ile Ala Glu Glu Ala Asp Phe Phe Ser Phe 
        755                 760                 765             

Gly Thr Asn Asp Leu Thr Gln Thr Thr Phe Gly Phe Ser Arg Asp Asp 
    770                 775                 780                 

Ala Glu Gly Lys Phe Leu Gln Gln Tyr Ile Glu Gln Lys Val Leu Pro 
785                 790                 795                 800 

Glu Asn Pro Phe Ala Val Leu Asp Gln Glu Gly Val Gly Lys Leu Val 
                805                 810                 815     

Glu Thr Gly Val Lys Leu Gly Arg Gln Thr Lys Pro Gly Leu Lys Thr 
            820                 825                 830         

Gly Ile Cys Gly Glu His Gly Gly Glu Lys Ser Ser Ile Glu Phe Cys 
        835                 840                 845             

Tyr Lys Thr Gly Leu Asn Tyr Val Ser Cys Ser Pro Tyr 
    850                 855                 860     

<210>   532
<211>   863
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   532
Met Ser Lys Lys Phe Val Tyr Leu Phe Arg Glu Gly Gln Ala Ser Met 
                5                   10                  15      

Arg Asp Leu Leu Gly Gly Lys Gly Ala Asn Leu Ala Glu Met Thr Asn 
            20                  25                  30          

Ile Gly Leu Pro Val Pro Pro Gly Phe Thr Ile Thr Thr Glu Ala Cys 
        35                  40                  45              

Asn Asp Tyr Tyr Ala Leu Gly Arg Asn Leu Pro Glu Gly Leu Trp Glu 
    50                  55                  60                  

Gln Ile Gly Pro Ala Leu Gly Asp Ile Glu Lys Ala Thr Gly Lys Lys 
65                  70                  75                  80  

Phe Gly Asp Lys Asp Asn Pro Leu Leu Val Ser Val Arg Ser Gly Ala 
                85                  90                  95      

Lys Phe Ser Met Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu 
            100                 105                 110         

Asn Asp Glu Thr Val Glu Gly Leu Ala Ala Ser Thr Gln Asn Ala Arg 
        115                 120                 125             

Phe Ala Tyr Asp Ser Tyr Arg Arg Phe Ile Gln Met Phe Gly Asp Val 
    130                 135                 140                 

Val Leu Glu Val Glu His His Glu Phe Glu Arg Ile Leu Glu Glu Ala 
145                 150                 155                 160 

Lys Glu Lys Gln Asn Val Asn Tyr Asp Ser Glu Leu Thr Ala Glu Ser 
                165                 170                 175     

Leu Lys Gly Val Val Glu Gly Tyr Lys Arg Leu Ile Gln Arg Arg Thr 
            180                 185                 190         

Gly Ser Pro Phe Pro Leu Asp Pro Met Lys Gln Leu Glu Gln Ala Ile 
        195                 200                 205             

Leu Ala Val Phe Arg Ser Trp Asn Asn Asp Arg Ala Ile Val Tyr Arg 
    210                 215                 220                 

Arg Ile Asn Ser Ile Pro Asp Asn Ile Gly Thr Ala Val Asn Val Gln 
225                 230                 235                 240 

Ser Met Val Phe Gly Asn Met Gly Asn Asp Ser Gly Thr Gly Val Ala 
                245                 250                 255     

Phe Thr Arg Asn Pro Ser Thr Gly Glu Arg Val Leu Tyr Gly Glu Tyr 
            260                 265                 270         

Leu Met Asn Ala Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro 
        275                 280                 285             

Gln Pro Ile Lys Ser Leu Glu Asp Glu Asn Lys Ala Ile Tyr Ala Gln 
    290                 295                 300                 

Phe Val Glu Thr Ser Asn Ser Leu Glu Ala His Tyr Arg Asp Met Gln 
305                 310                 315                 320 

Asp Ile Glu Phe Thr Ile Glu Arg Gly Arg Leu Tyr Ile Leu Gln Thr 
                325                 330                 335     

Arg Asn Gly Lys Arg Thr Ala Pro Ala Ala Ile Arg Val Ala Val Glu 
            340                 345                 350         

Leu Cys Arg Glu Gly Val Ile Ser Lys Glu Glu Ala Ile Ala Arg Ile 
        355                 360                 365             

Glu Pro Gly Gln Leu Asp Gln Leu Leu His Arg Arg Met Asp Ser Glu 
    370                 375                 380                 

Ala Lys Leu Glu Val Ile Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala 
385                 390                 395                 400 

Ala Ser Gly Lys Ile Val Phe Asp Ala Asp Glu Ala Glu Arg Leu Gly 
                405                 410                 415     

His Thr Gly Glu Arg Val Leu Leu Val Arg Thr Glu Thr Thr Pro Asp 
            420                 425                 430         

Asp Ile His Gly Ile Leu Ala Ala Gln Gly Ile Leu Thr Ser Arg Gly 
        435                 440                 445             

Gly Met Thr Ser His Ala Ala Val Val Ala Arg His Met Gly Lys Pro 
    450                 455                 460                 

Ala Val Cys Gly Cys Glu Ala Leu Arg Ile Asp Tyr Ala His Asn Thr 
465                 470                 475                 480 

Val Thr Ile Asp Gly Val Thr Tyr Pro Glu Gly Thr Leu Phe Ser Ile 
                485                 490                 495     

Asp Gly Thr Thr Gly Arg Val Ile Lys Gly Ala Val Pro Met Ile Asp 
            500                 505                 510         

Pro Glu Leu Ser Glu Glu Phe Lys Glu Leu Leu Gly Trp Ala Asp Glu 
        515                 520                 525             

Ile Arg Thr Leu Lys Val Leu Ala Asn Ala Asp Asn Pro Arg Asp Ala 
    530                 535                 540                 

Gln Lys Ala Arg Asp Phe Gly Ala Gln Gly Ile Gly Leu Cys Arg Thr 
545                 550                 555                 560 

Glu His Met Phe Met Asp Pro Ala Arg Ile Pro Ile Val Gln Glu Met 
                565                 570                 575     

Ile Leu Ala Gln Thr Leu Pro Glu Arg Glu Val Ala Leu Ala Lys Leu 
            580                 585                 590         

Leu Pro Met Gln Glu Glu Asp Phe Tyr Gly Ile Leu Lys Val Met Ala 
        595                 600                 605             

Gly Phe Pro Val Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe 
    610                 615                 620                 

Leu Pro Asn Val Glu Glu Leu Val Val Asp Ile Thr Lys Leu Lys Leu 
625                 630                 635                 640 

Gln Gly Asp Arg Glu Glu Glu Leu Asn Glu Lys Glu Val Leu Leu Arg 
                645                 650                 655     

Lys Val Arg Ala Leu Ser Glu Met Asn Pro Met Leu Gly His Arg Gly 
            660                 665                 670         

Cys Arg Leu Gly Ile Thr Phe Pro Glu Ile Tyr Ala Met Gln Ala Arg 
        675                 680                 685             

Ala Ile Phe Gln Ala Ser Ala Arg Leu Val Lys Glu Gly Cys Glu Ile 
    690                 695                 700                 

His Pro Glu Val Met Ile Pro Leu Val Ile His Val Lys Glu Leu Ala 
705                 710                 715                 720 

Lys Leu Arg Lys Val Thr Glu Glu Ala Ala Gln Thr Val Met Ala Glu 
                725                 730                 735     

Gln Gly Val Thr Phe Ser Tyr Thr Ile Gly Thr Met Ile Glu Val Pro 
            740                 745                 750         

Arg Ala Ala Leu Thr Ala Asp Glu Val Ala Thr Ala Ala Asp Phe Phe 
        755                 760                 765             

Ser Phe Gly Thr Asn Asp Leu Thr Gln Thr Thr Leu Gly Phe Ser Arg 
    770                 775                 780                 

Asp Asp Ala Glu Gly Lys Phe Leu Pro Ala Tyr Leu Glu Gln Asn Ile 
785                 790                 795                 800 

Leu Glu His Asn Pro Phe Ala Val Leu Asp Arg Ile Gly Val Gly Lys 
                805                 810                 815     

Leu Met Lys Met Gly Val Gln Leu Gly Arg Glu Ala Asn Pro Gly Leu 
            820                 825                 830         

Lys Val Gly Ile Cys Gly Glu His Gly Gly Asp Pro Ser Ser Ile Glu 
        835                 840                 845             

Phe Cys His Gln Ile Gly Leu Asn Tyr Val Ser Cys Ser Pro Phe 
    850                 855                 860             

<210>   533
<211>   863
<212>   PRT
<213>   Desulfitobacterium hafniense DCB-2

<400>   533
Met Ser Lys Lys Phe Val Tyr Leu Phe Arg Glu Gly Gln Ala Ser Met 
                5                   10                  15      

Arg Asp Leu Leu Gly Gly Lys Gly Ala Asn Leu Ala Glu Met Thr Asn 
            20                  25                  30          

Ile Gly Leu Pro Val Pro Pro Gly Phe Thr Ile Thr Thr Glu Ala Cys 
        35                  40                  45              

Asn Asp Tyr Tyr Ala Leu Gly Arg Asn Leu Pro Glu Gly Leu Trp Glu 
    50                  55                  60                  

Gln Ile Gly Pro Ala Leu Gly Asp Ile Glu Lys Ala Thr Gly Lys Lys 
65                  70                  75                  80  

Phe Gly Asp Lys Asp Asn Pro Leu Leu Val Ser Val Arg Ser Gly Ala 
                85                  90                  95      

Lys Phe Ser Met Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu 
            100                 105                 110         

Asn Asp Glu Thr Val Glu Gly Leu Ala Ala Ser Thr Gln Asn Ala Arg 
        115                 120                 125             

Phe Ala Tyr Asp Ser Tyr Arg Arg Phe Ile Gln Met Phe Gly Asp Val 
    130                 135                 140                 

Val Leu Glu Val Glu His His Glu Phe Glu Arg Ile Leu Glu Glu Ala 
145                 150                 155                 160 

Lys Glu Lys Gln Asn Val Asn Tyr Asp Ser Glu Leu Thr Ala Glu Ser 
                165                 170                 175     

Leu Lys Gly Val Val Glu Gly Tyr Lys Arg Leu Ile Gln Arg Arg Thr 
            180                 185                 190         

Gly Ser Pro Phe Pro Leu Glu Pro Met Lys Gln Leu Glu Gln Ala Ile 
        195                 200                 205             

Leu Ala Val Phe Arg Ser Trp Asn Asn Asp Arg Ala Ile Val Tyr Arg 
    210                 215                 220                 

Arg Ile Asn Ser Ile Pro Asp Asn Ile Gly Thr Ala Val Asn Val Gln 
225                 230                 235                 240 

Ser Met Val Phe Gly Asn Met Gly Asn Asp Ser Gly Thr Gly Val Ala 
                245                 250                 255     

Phe Thr Arg Asn Pro Ser Thr Gly Glu Arg Val Leu Tyr Gly Glu Tyr 
            260                 265                 270         

Leu Met Asn Ala Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro 
        275                 280                 285             

Gln Pro Ile Lys Ser Leu Glu Asp Glu Asn Gln Ala Ile Tyr Ala Gln 
    290                 295                 300                 

Phe Val Lys Thr Ser Asn Ser Leu Glu Ala His Tyr Arg Asp Met Gln 
305                 310                 315                 320 

Asp Ile Glu Phe Thr Ile Glu Arg Gly Arg Leu Tyr Ile Leu Gln Thr 
                325                 330                 335     

Arg Asn Gly Lys Arg Thr Ala Pro Ala Ala Ile Arg Val Ala Val Glu 
            340                 345                 350         

Leu Cys Arg Glu Gly Val Ile Ser Lys Glu Glu Ala Ile Ala Arg Ile 
        355                 360                 365             

Glu Pro Gly Gln Leu Asp Gln Leu Leu His Arg Arg Met Asp Ser Glu 
    370                 375                 380                 

Ala Lys Leu Glu Val Ile Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala 
385                 390                 395                 400 

Ala Ser Gly Lys Ile Val Phe Asp Ala Asp Glu Ala Glu Arg Leu Gly 
                405                 410                 415     

His Thr Gly Glu Lys Val Leu Leu Val Arg Thr Glu Thr Thr Pro Asp 
            420                 425                 430         

Asp Ile His Gly Ile Leu Ala Ala Gln Gly Ile Leu Thr Ser Arg Gly 
        435                 440                 445             

Gly Met Thr Ser His Ala Ala Val Val Ala Arg His Met Gly Lys Pro 
    450                 455                 460                 

Ala Val Cys Gly Cys Glu Ala Leu Arg Ile Asp Tyr Ala His Asn Thr 
465                 470                 475                 480 

Val Thr Ile Asp Gly Val Thr Tyr Pro Glu Gly Thr Leu Phe Ser Ile 
                485                 490                 495     

Asp Gly Thr Thr Gly Arg Val Ile Lys Gly Ala Val Pro Met Ile Asp 
            500                 505                 510         

Pro Glu Leu Ser Glu Glu Phe Lys Glu Leu Leu Gly Trp Ala Asp Glu 
        515                 520                 525             

Ile Arg Thr Leu Lys Val Leu Ala Asn Ala Asp Asn Pro Arg Asp Ala 
    530                 535                 540                 

Gln Lys Ala Arg Asp Phe Gly Ala Gln Gly Ile Gly Leu Cys Arg Thr 
545                 550                 555                 560 

Glu His Met Phe Met Asp Pro Ala Arg Ile Pro Ile Val Gln Glu Met 
                565                 570                 575     

Ile Leu Ala Gln Thr Leu Pro Glu Arg Glu Val Ala Leu Ala Lys Leu 
            580                 585                 590         

Leu Pro Met Gln Glu Glu Asp Phe Tyr Gly Ile Leu Lys Val Met Ala 
        595                 600                 605             

Gly Phe Pro Val Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe 
    610                 615                 620                 

Leu Pro Asn Val Glu Glu Leu Val Val Asp Ile Thr Lys Leu Lys Leu 
625                 630                 635                 640 

Gln Gly Asp Arg Glu Glu Glu Leu Asn Glu Lys Glu Val Leu Leu Arg 
                645                 650                 655     

Lys Val Arg Ala Leu Ser Glu Met Asn Pro Met Leu Gly His Arg Gly 
            660                 665                 670         

Cys Arg Leu Gly Ile Thr Phe Pro Glu Ile Tyr Ala Met Gln Ala Arg 
        675                 680                 685             

Ala Ile Phe Gln Ala Ala Ala Arg Leu Val Lys Glu Gly Tyr Glu Ile 
    690                 695                 700                 

Tyr Pro Glu Val Met Ile Pro Leu Val Ile His Val Lys Glu Leu Ala 
705                 710                 715                 720 

Lys Leu Arg Lys Val Thr Glu Glu Ala Ala Gln Thr Val Met Ala Glu 
                725                 730                 735     

Gln Gly Val Thr Phe Ala Tyr Thr Ile Gly Thr Met Ile Glu Val Pro 
            740                 745                 750         

Arg Ala Ala Leu Thr Ala Asp Glu Val Ala Thr Ala Ala Asp Phe Phe 
        755                 760                 765             

Ser Phe Gly Thr Asn Asp Leu Thr Gln Thr Thr Leu Gly Phe Ser Arg 
    770                 775                 780                 

Asp Asp Ala Glu Gly Lys Phe Leu Pro Ala Tyr Leu Glu Gln Asn Ile 
785                 790                 795                 800 

Leu Glu His Asn Pro Phe Ala Val Leu Asp Arg Ile Gly Val Gly Lys 
                805                 810                 815     

Leu Met Lys Met Gly Val Gln Leu Gly Arg Glu Ala Asn Pro Gly Leu 
            820                 825                 830         

Lys Val Gly Ile Cys Gly Glu His Gly Gly Asp Pro Ser Ser Ile Glu 
        835                 840                 845             

Phe Cys His Gln Ile Gly Leu Asn Tyr Val Ser Cys Ser Pro Phe 
    850                 855                 860             

<210>   534
<211>   860
<212>   PRT
<213>   Moorella thermoacetica ATCC 39073

<400>   534
Lys Tyr Val Tyr Leu Phe Ser Glu Gly Lys Ala Asp Met Arg Leu Leu 
                5                   10                  15      

Leu Gly Gly Lys Gly Ala Asn Leu Ala Glu Met Thr Asn Ile Gly Leu 
            20                  25                  30          

Pro Val Pro Gln Gly Ile Thr Ile Thr Cys Glu Ala Cys Asn Glu Tyr 
        35                  40                  45              

Asn Arg Leu Gly Gln Gln Phe Pro Glu Gly Leu Glu Glu Glu Val Ala 
    50                  55                  60                  

Ala Arg Leu Lys Asp Leu Glu Ala Ile Asn Gly Lys Lys Leu Gly Asp 
65                  70                  75                  80  

Pro Glu Asn Pro Leu Leu Val Ser Val Arg Ser Gly Ala Pro Val Ser 
                85                  90                  95      

Met Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu Asn Asp Asn 
            100                 105                 110         

Ser Val Lys Gly Leu Ala Ala Gln Thr Gly Asp Glu Arg Phe Ala Leu 
        115                 120                 125             

Asp Cys Tyr Arg Arg Phe Ile Gln Met Phe Gly Asn Val Val Leu Gly 
    130                 135                 140                 

Ile Glu His Asn Asp Phe Glu Ala Val Leu Glu Lys His Lys Glu Arg 
145                 150                 155                 160 

Leu Gly Val Lys Phe Asp His Glu Leu Thr Pro Asp Ala Leu Arg Glu 
                165                 170                 175     

Val Ile Ala Glu Tyr Lys Asp Val Val Lys Ser Arg Ser Gly Arg Asp 
            180                 185                 190         

Phe Pro Gln Asp Pro Arg Glu Gln Leu Tyr Met Ala Ile Arg Ala Val 
        195                 200                 205             

Phe Asp Ser Trp Asn Asn Pro Arg Ala Ile Val Tyr Arg Lys Ile Asn 
    210                 215                 220                 

Lys Ile Pro Asp Asp Leu Gly Thr Ala Val Asn Val Gln Thr Met Ala 
225                 230                 235                 240 

Phe Gly Asn Met Gly Pro Thr Ser Gly Thr Gly Val Ala Phe Thr Arg 
                245                 250                 255     

Asn Pro Ser Thr Gly Glu Lys Gly Ile Tyr Gly Glu Tyr Leu Ile Asn 
            260                 265                 270         

Ala Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Lys Pro Ile 
        275                 280                 285             

Ser Ser Leu Lys Glu Glu Met Pro Glu Val Tyr Arg Gln Phe Glu Asp 
    290                 295                 300                 

Ile Cys Gln Leu Leu Glu Lys His Tyr Arg Asp Met Gln Asp Ile Glu 
305                 310                 315                 320 

Phe Thr Ile Glu Lys Gly Lys Leu Phe Ile Leu Gln Thr Arg Asn Gly 
                325                 330                 335     

Lys Arg Thr Ala Ala Ala Ala Val Lys Ile Ala Val Asp Met Val Asn 
            340                 345                 350         

Glu Gly Leu Ile Thr Lys Glu Glu Ala Val Leu Arg Val Asp Ala Asp 
        355                 360                 365             

Gln Leu Ile Gln Leu Met His Arg Arg Ile Asp Pro Ser Ala Lys Leu 
    370                 375                 380                 

Glu Val Val Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ala Ser Gly 
385                 390                 395                 400 

Gln Val Val Phe Asp Ala Asp Asp Ala Glu Lys Met Gly Leu Asp Gly 
                405                 410                 415     

Gln Lys Val Val Leu Val Arg Thr Glu Thr Thr Pro Asp Asp Ile His 
            420                 425                 430         

Gly Ile Val Gln Ala Gln Gly Val Leu Thr Ala Arg Gly Gly Met Thr 
        435                 440                 445             

Ser His Ala Ala Val Val Ala Arg Gly Met Gly Lys Pro Ala Val Thr 
    450                 455                 460                 

Gly Cys Asp Ala Ile Lys Ile Asp Val Glu Asn Lys Arg Phe Phe Ile 
465                 470                 475                 480 

Gly Asp Leu Val Val Lys Glu Gly Asp Val Ile Ser Ile Asp Gly Ser 
                485                 490                 495     

Thr Gly Asn Val Met Leu Gly Glu Val Pro Leu Ile Asp Pro Gln Leu 
            500                 505                 510         

Thr Gly Glu Phe Glu Thr Ile Leu Glu Trp Ala Asp Ser Phe Arg Arg 
        515                 520                 525             

Leu Lys Val Arg Ala Asn Ala Asp Thr Pro Glu Asp Ala Arg Arg Ser 
    530                 535                 540                 

Arg Glu Phe Gly Ala Asp Gly Ile Gly Leu Thr Arg Thr Glu His Met 
545                 550                 555                 560 

Phe Met Gln Val Asp Arg Leu Pro Val Val Gln Gln Met Ile Leu Ala 
                565                 570                 575     

Lys Thr Lys Glu Glu Arg Gln Ala Ala Leu Asp Lys Leu Leu Pro Met 
            580                 585                 590         

Gln Gln Gly Asp Phe Tyr Gly Ile Leu Lys Ala Met Glu Gly Leu Pro 
        595                 600                 605             

Val Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu Pro Asn 
    610                 615                 620                 

Ile Glu Glu Leu Leu Val Asp Val Thr Arg Leu Gln Ala Thr Asn Gly 
625                 630                 635                 640 

Asp Ser Lys Glu Leu Glu Glu Lys Gln Ala Leu Leu Arg Glu Val Arg 
                645                 650                 655     

Ala Arg His Glu Phe Asn Pro Met Leu Gly His Arg Gly Cys Arg Leu 
            660                 665                 670         

Gly Ile Thr Tyr Pro Glu Ile Tyr Ala Met Gln Val Arg Ala Ile Phe 
        675                 680                 685             

Gln Ala Val Ala Gln Leu Val Lys Glu Gly Val Lys Val Leu Pro Glu 
    690                 695                 700                 

Val Glu Ile Pro Leu Val Ile His Val Asn Glu Leu Gln Arg Leu His 
705                 710                 715                 720 

Ala Met Val Asp Glu Val Ala Ala Ala Val Lys Lys Glu Thr Gly Val 
                725                 730                 735     

Asp Phe Asp Tyr Lys Val Gly Thr Met Ile Glu Met Pro Arg Ala Cys 
            740                 745                 750         

Ala Thr Ala Asp Glu Ile Ala Arg Glu Ala Glu Phe Phe Ser Phe Gly 
        755                 760                 765             

Thr Asn Asp Leu Thr Gln Thr Thr Phe Gly Phe Ser Arg Asp Asp Ala 
    770                 775                 780                 

Glu Gly Lys Phe Leu His Gln Tyr Val Asp Glu Lys Ile Leu Lys Glu 
785                 790                 795                 800 

Asp Pro Phe Ile Val Leu Asp Arg Asp Gly Val Gly Lys Phe Met Lys 
                805                 810                 815     

Met Ala Val Glu Leu Gly Arg Ser Thr Asn Pro Lys Leu Glu Ile Gly 
            820                 825                 830         

Ile Cys Gly Glu His Gly Gly Glu Pro Ser Ser Val Glu Phe Cys His 
        835                 840                 845             

Gln Ile Gly Leu Asn Tyr Val Ser Cys Ser Pro Phe 
    850                 855                 860 

<210>   535
<211>   927
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   535
Met Ser His Gly Glu Leu Ala Ala Ser Ala Arg Arg Pro Met Cys Lys 
                5                   10                  15      

Arg Phe Ala Gly Trp Ala Thr Arg Arg Pro Arg Gln Gly Gly Cys Lys 
            20                  25                  30          

Met Ala Gln Val Gln Asp Val Gln Arg Asp Gln Ala Leu Thr Thr Arg 
        35                  40                  45              

Trp Val Tyr Ser Phe Asp Gln Ala Asp Pro Lys Asn Arg Ser Leu Leu 
    50                  55                  60                  

Gly Gly Lys Gly Ala Asn Leu Ala Gln Met Val Gln Trp Gly Phe Pro 
65                  70                  75                  80  

Val Pro Pro Gly Phe Thr Ile Thr Thr Glu Ala Cys Asn Glu Tyr Trp 
                85                  90                  95      

Ala Arg Gly Gly Lys Phe Pro Glu Gly Leu Leu Asp Glu Val Ala Leu 
            100                 105                 110         

Ala Ile Leu Arg Leu Glu Arg Thr Ala Gly Lys Arg Phe Gly Asp Ala 
        115                 120                 125             

Phe Gln Pro Leu Leu Val Ser Val Arg Ser Gly Ala Pro Val Ser Met 
    130                 135                 140                 

Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu Asn Asp Leu Thr 
145                 150                 155                 160 

Val Arg Ala Leu Ala Asn Gln Ser Gln Asp Pro Ala Phe Ala Tyr Asp 
                165                 170                 175     

Ser Tyr Arg Arg Leu Ile Gln Met Phe Ala Asn Val Val Phe Asn Val 
            180                 185                 190         

Ser Leu Glu Pro Phe Glu His Ala Leu Arg Ala Ala Lys Ala Lys His 
        195                 200                 205             

Gly Val Glu Arg Asp Arg Asp Leu Pro Ala Asp Ala Trp Lys Asp Leu 
    210                 215                 220                 

Val Ala Thr Tyr Leu Lys Leu Phe Ala Glu His Val Gly Gln Pro Phe 
225                 230                 235                 240 

Pro Gln Asp Val Asn Val Gln Leu Glu Leu Ala Ile Glu Ala Val Phe 
                245                 250                 255     

Arg Ser Trp Asn Ser Pro Arg Ala Ile Val Tyr Arg Lys Ala His Gly 
            260                 265                 270         

Ile Pro Glu Thr Leu Gly Thr Ala Val Asn Val Gln Ala Met Val Phe 
        275                 280                 285             

Gly Asn Met Gly Asp Asp Ser Gly Thr Gly Val Ile Phe Thr Arg His 
    290                 295                 300                 

Pro Ser Thr Gly Glu Pro Val Leu Phe Gly Glu Phe Leu Ala Asn Ala 
305                 310                 315                 320 

Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Gln Pro Ile Ala 
                325                 330                 335     

Asp Leu Ala His Thr Met Pro His Val Tyr Glu Ser Leu Val Ala Leu 
            340                 345                 350         

Ala Lys Gln Leu Glu Thr Arg Phe Arg Asp Met Gln Asp Val Glu Phe 
        355                 360                 365             

Thr Val Glu Arg Gly Lys Leu Phe Val Leu Gln Thr Arg Ser Gly Lys 
    370                 375                 380                 

Arg Thr Ala Gln Ala Ala Val Arg Ile Ala Ile Asp Met Leu His Glu 
385                 390                 395                 400 

Gly Leu Ile Gln Pro Glu Glu Ala Leu Leu Arg Val Asp Ala Gln His 
                405                 410                 415     

Leu Arg Gln Leu Leu His Arg Arg Leu Gln Gly Thr Asp Ala Leu Gln 
            420                 425                 430         

Val Phe Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ser Val Gly Arg 
        435                 440                 445             

Ile Val Leu Asp Ala Asp Thr Ala Val Glu Trp Ala Gln Arg Gly Glu 
    450                 455                 460                 

Lys Val Val Leu Val Arg Pro Glu Thr Thr Pro Glu Asp Ile His Gly 
465                 470                 475                 480 

Val Leu Ala Ala Glu Gly Val Val Thr Thr His Gly Gly Met Thr Ser 
                485                 490                 495     

His Ala Ala Val Val Ala Arg Gly Ile Gly Lys Pro Ala Val Cys Gly 
            500                 505                 510         

Cys Asp Gly Val His Ile Asp Phe Glu Ala Arg Gln Val Glu Ser Asn 
        515                 520                 525             

Gly Val Val Leu Lys Glu Gly Asp Val Ile Ser Val Asp Gly Gly Thr 
    530                 535                 540                 

Gly Thr Val Tyr Val Gly Glu Ala Gln Met Glu Glu Ala Lys Met Ala 
545                 550                 555                 560 

Asp Glu Leu Lys Glu Leu Leu Ser Ile Ala Asp Gln Val Arg Arg Leu 
                565                 570                 575     

Lys Val Arg Ala Asn Ala Asp Thr Pro Glu Asp Ala Arg Arg Ala Arg 
            580                 585                 590         

Glu Phe Gly Ala Glu Gly Ile Gly Leu Cys Arg Thr Glu His Met Phe 
        595                 600                 605             

Leu Ser Pro Asp Arg Val Pro Leu Val Gln Arg Met Ile Leu Ala Thr 
    610                 615                 620                 

Thr Ser Ala Glu Arg Gln Ala Ala Leu Ser Lys Leu Leu Pro Leu Gln 
625                 630                 635                 640 

Val Ser Asp Phe Thr Ala Ile Phe Glu Ala Met Asp Gly Leu Pro Val 
                645                 650                 655     

Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu Pro Arg Glu 
            660                 665                 670         

Glu Glu Leu Ala Glu Arg Leu Glu Glu Leu Arg Ala Gln Gly Ala Ser 
        675                 680                 685             

Glu Asp Glu Ile Ala Glu Thr Glu Gln Leu Leu Arg Gln Ala Arg Tyr 
    690                 695                 700                 

Leu Arg Glu Ala Asn Pro Met Met Gly Leu Arg Gly Ser Arg Leu Gly 
705                 710                 715                 720 

Ile Val Tyr Pro Glu Ile Tyr Asp Met Gln Met Glu Ala Ile Ile Thr 
                725                 730                 735     

Ala Ala Ala Gln Ala Lys Arg Arg Gly Ile Ala Val Asp Leu Glu Val 
            740                 745                 750         

Met Leu Pro Leu Ile Gly Ser Pro Lys Glu Leu Arg Val Leu Arg Glu 
        755                 760                 765             

Arg Met Glu Glu Ile Ala Lys Arg Thr Met Glu Arg Glu Gly Val Glu 
    770                 775                 780                 

Ile Glu Tyr Arg Ile Gly Thr Met Ile Glu Val Pro Arg Ala Ala Leu 
785                 790                 795                 800 

Thr Ala Asp Gln Ile Ala Glu Asp Ala Gln Phe Phe Ser Phe Gly Thr 
                805                 810                 815     

Asn Asp Leu Thr Gln Met Thr Phe Ala Phe Ser Arg Asp Asp Ala Glu 
            820                 825                 830         

Gly Lys Phe Leu Asn Val Tyr Leu Asp Arg Glu Ile Leu Pro Tyr Asn 
        835                 840                 845             

Pro Phe Glu Thr Leu Asp Thr Glu Gly Val Gly Lys Leu Ile Gln Trp 
    850                 855                 860                 

Ala Val Glu Ala Gly Arg Lys Arg Arg Pro Asp Leu Lys Thr Gly Val 
865                 870                 875                 880 

Cys Gly Glu His Gly Gly Asp Pro Ala Ser Ile Ala Phe Cys Glu Asp 
                885                 890                 895     

Ile Gly Leu Asp Tyr Val Ser Cys Ser Pro Phe Arg Ile Pro Val Ala 
            900                 905                 910         

Arg Ile Ala Ala Ala Gln Ala Ala Val Arg Arg Arg Met Thr Gly 
        915                 920                 925         

<210>   536
<211>   927
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   536
Met Ser His Gly Glu Leu Ala Ala Ser Ala Arg Arg Pro Met Cys Lys 
                5                   10                  15      

Arg Phe Ala Gly Trp Ala Thr Arg Arg Pro Arg Gln Gly Gly Cys Lys 
            20                  25                  30          

Met Ala Gln Val Gln Asp Val Gln Arg Asp Gln Ala Leu Thr Thr Arg 
        35                  40                  45              

Trp Val Tyr Ser Phe Asp Gln Ala Asp Pro Lys Asn Arg Ser Leu Leu 
    50                  55                  60                  

Gly Gly Lys Gly Ala Asn Leu Ala Gln Met Val Gln Trp Gly Phe Pro 
65                  70                  75                  80  

Val Pro Pro Gly Phe Thr Ile Thr Thr Glu Ala Cys Asn Glu Tyr Trp 
                85                  90                  95      

Ala Arg Gly Gly Lys Phe Pro Glu Gly Leu Leu Asp Glu Val Ala Leu 
            100                 105                 110         

Ala Ile Leu Arg Leu Glu Arg Thr Ala Gly Lys Arg Phe Gly Asp Ala 
        115                 120                 125             

Phe Gln Pro Leu Leu Val Ser Val Arg Ser Gly Ala Pro Val Ser Met 
    130                 135                 140                 

Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu Asn Asp Leu Thr 
145                 150                 155                 160 

Val Arg Ala Leu Ala Asn Gln Ser Gln Asp Pro Ala Phe Ala Tyr Asp 
                165                 170                 175     

Ser Tyr Arg Arg Leu Ile Gln Met Phe Ala Asn Val Val Phe Asn Val 
            180                 185                 190         

Ser Leu Glu Pro Phe Glu His Ala Leu Arg Ala Ala Lys Ala Lys His 
        195                 200                 205             

Gly Val Glu Arg Asp Arg Asp Leu Pro Ala Asp Ala Trp Lys Asp Leu 
    210                 215                 220                 

Val Ala Thr Tyr Leu Lys Leu Phe Ala Glu His Val Gly Gln Pro Phe 
225                 230                 235                 240 

Pro Gln Asp Val Asn Val Gln Leu Glu Leu Ala Ile Glu Ala Val Phe 
                245                 250                 255     

Arg Ser Trp Asn Ser Pro Arg Ala Ile Val Tyr Arg Lys Ala His Gly 
            260                 265                 270         

Ile Pro Glu Thr Leu Gly Thr Ala Val Asn Val Gln Ala Met Val Phe 
        275                 280                 285             

Gly Asn Met Gly Asp Asp Ser Gly Thr Gly Val Ile Phe Thr Arg His 
    290                 295                 300                 

Pro Ser Thr Gly Glu Pro Val Leu Phe Gly Glu Phe Leu Ala Asn Ala 
305                 310                 315                 320 

Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Gln Pro Ile Ala 
                325                 330                 335     

Asp Leu Ala His Thr Met Pro His Val Tyr Glu Ser Leu Val Ala Ile 
            340                 345                 350         

Ala Lys Gln Leu Glu Thr Arg Phe Arg Asp Met Gln Asp Val Glu Phe 
        355                 360                 365             

Thr Val Glu Arg Gly Lys Leu Phe Val Leu Gln Thr Arg Ser Gly Lys 
    370                 375                 380                 

Arg Thr Ala Gln Ala Ala Val Arg Ile Ala Ile Asp Met Leu His Glu 
385                 390                 395                 400 

Gly Leu Ile Gln Pro Glu Glu Ala Leu Leu Arg Val Asp Ala Gln His 
                405                 410                 415     

Leu Arg Gln Leu Leu His Arg Arg Leu Gln Gly Thr Asp Ala Leu Gln 
            420                 425                 430         

Val Phe Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ser Val Gly Arg 
        435                 440                 445             

Ile Val Leu Asp Ala Asp Thr Ala Val Glu Trp Ala Gln Arg Gly Glu 
    450                 455                 460                 

Lys Val Val Leu Val Arg Pro Glu Thr Thr Pro Glu Asp Ile His Gly 
465                 470                 475                 480 

Val Leu Ala Ala Glu Gly Val Val Thr Thr His Gly Gly Met Thr Ser 
                485                 490                 495     

His Ala Ala Val Val Ala Arg Gly Ile Gly Lys Pro Ala Val Cys Gly 
            500                 505                 510         

Cys Asp Gly Val His Ile Asp Phe Glu Ala Arg Gln Val Glu Ser Asn 
        515                 520                 525             

Gly Val Val Leu Lys Glu Gly Asp Val Ile Ser Val Asp Gly Gly Thr 
    530                 535                 540                 

Gly Thr Val Tyr Val Gly Glu Ala Gln Met Glu Glu Ala Lys Met Ala 
545                 550                 555                 560 

Asp Glu Leu Lys Glu Leu Leu Ser Ile Ala Asp Gln Val Arg Arg Leu 
                565                 570                 575     

Lys Val Arg Ala Asn Ala Asp Thr Pro Glu Asp Ala Arg Arg Ala Arg 
            580                 585                 590         

Glu Phe Gly Ala Glu Gly Ile Gly Leu Cys Arg Thr Glu His Met Phe 
        595                 600                 605             

Leu Ser Pro Asp Arg Val Pro Leu Val Gln Arg Met Ile Leu Ala Thr 
    610                 615                 620                 

Thr Ser Ala Glu Arg Gln Ala Ala Leu Ser Lys Leu Leu Pro Leu Gln 
625                 630                 635                 640 

Val Ser Asp Phe Thr Ala Ile Phe Glu Ala Met Asp Gly Leu Pro Val 
                645                 650                 655     

Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu Pro Arg Glu 
            660                 665                 670         

Glu Glu Leu Ala Glu Arg Leu Glu Glu Leu Arg Ala Gln Gly Ala Ser 
        675                 680                 685             

Glu Asp Glu Ile Ala Glu Thr Glu Gln Leu Leu Arg Gln Ala Arg Tyr 
    690                 695                 700                 

Leu Arg Glu Ala Asn Pro Met Met Gly Leu Arg Gly Ser Arg Leu Gly 
705                 710                 715                 720 

Ile Val Tyr Pro Glu Ile Tyr Asp Met Gln Met Glu Ala Ile Ile Thr 
                725                 730                 735     

Ala Ala Ala Gln Ala Lys Arg Arg Gly Ile Ala Val Asp Leu Glu Val 
            740                 745                 750         

Met Leu Pro Leu Ile Gly Ser Pro Lys Glu Leu Arg Val Leu Arg Glu 
        755                 760                 765             

Arg Met Glu Glu Ile Ala Lys Arg Thr Met Glu Arg Glu Gly Val Glu 
    770                 775                 780                 

Ile Glu Tyr Arg Ile Gly Thr Met Ile Glu Val Pro Arg Ala Ala Leu 
785                 790                 795                 800 

Thr Ala Asp Gln Ile Ala Glu Asp Ala Gln Phe Phe Ser Phe Gly Thr 
                805                 810                 815     

Asn Asp Leu Thr Gln Met Thr Phe Ala Phe Ser Arg Asp Asp Ala Glu 
            820                 825                 830         

Gly Lys Phe Leu Asn Val Tyr Leu Asp Arg Glu Ile Leu Pro Tyr Asn 
        835                 840                 845             

Pro Phe Glu Thr Leu Asp Thr Glu Gly Val Gly Lys Leu Ile Gln Trp 
    850                 855                 860                 

Ala Val Glu Ala Gly Arg Lys Arg Arg Pro Asp Leu Lys Thr Gly Val 
865                 870                 875                 880 

Cys Gly Glu His Gly Gly Asp Pro Ala Ser Ile Ala Phe Cys Glu Asp 
                885                 890                 895     

Ile Gly Leu Asp Tyr Val Ser Cys Ser Pro Phe Arg Ile Pro Val Ala 
            900                 905                 910         

Arg Ile Ala Ala Ala Gln Ala Ala Val Arg Lys Arg Met Thr Gly 
        915                 920                 925         

<210>   537
<211>   927
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   537
Met Ser His Gly Glu Leu Ala Ala Ser Ala Arg Arg Pro Met Cys Lys 
                5                   10                  15      

Arg Phe Ala Gly Trp Ala Thr Arg Arg Pro Arg Gln Gly Gly Cys Lys 
            20                  25                  30          

Met Ala Gln Val Gln Asp Val Gln Arg Asp Gln Ala Leu Thr Thr Arg 
        35                  40                  45              

Trp Val Tyr Ser Phe Asp Gln Ala Asp Pro Lys Asn Arg Ser Leu Leu 
    50                  55                  60                  

Gly Gly Lys Gly Ala Asn Leu Ala Gln Met Val Gln Trp Gly Phe Pro 
65                  70                  75                  80  

Val Pro Pro Gly Phe Thr Ile Thr Thr Glu Ala Cys Asn Glu Tyr Trp 
                85                  90                  95      

Ala Arg Gly Gly Lys Phe Pro Glu Gly Leu Leu Asp Glu Val Ala Leu 
            100                 105                 110         

Ala Ile Leu Arg Leu Glu Arg Thr Ala Gly Lys Arg Phe Gly Asp Ala 
        115                 120                 125             

Phe Gln Pro Leu Leu Val Ser Val Arg Ser Gly Ala Pro Val Ser Met 
    130                 135                 140                 

Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu Asn Asp Leu Thr 
145                 150                 155                 160 

Val Arg Ala Leu Ala Asn Gln Ser Gln Asp Pro Ala Phe Ala Tyr Asp 
                165                 170                 175     

Ser Tyr Arg Arg Leu Ile Gln Met Phe Ala Asn Val Val Phe Asn Val 
            180                 185                 190         

Ser Leu Glu Pro Phe Glu His Ala Leu Arg Ala Ala Lys Ala Lys His 
        195                 200                 205             

Gly Val Glu Arg Asp Arg Asp Leu Pro Ala Asp Ala Trp Lys Asp Leu 
    210                 215                 220                 

Val Ala Thr Tyr Leu Lys Leu Phe Ala Glu His Val Gly Gln Pro Phe 
225                 230                 235                 240 

Pro Gln Asp Val Asn Val Gln Leu Glu Leu Ala Ile Glu Ala Val Phe 
                245                 250                 255     

Arg Ser Trp Asn Ser Pro Arg Ala Ile Val Tyr Arg Lys Ala His Gly 
            260                 265                 270         

Ile Pro Glu Thr Leu Gly Thr Ala Val Asn Val Gln Ala Met Val Phe 
        275                 280                 285             

Gly Asn Met Gly Asp Asp Ser Gly Thr Gly Val Ile Phe Thr Arg His 
    290                 295                 300                 

Pro Ser Thr Gly Glu Pro Val Leu Phe Gly Glu Phe Leu Ala Asn Ala 
305                 310                 315                 320 

Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Gln Pro Ile Ala 
                325                 330                 335     

Asp Leu Ala His Thr Met Pro His Val Tyr Glu Ser Leu Val Ala Leu 
            340                 345                 350         

Ala Lys Gln Leu Glu Thr Arg Phe Arg Asp Met Gln Asp Val Glu Phe 
        355                 360                 365             

Thr Val Glu Arg Gly Lys Leu Phe Val Leu Gln Thr Arg Ser Gly Lys 
    370                 375                 380                 

Arg Thr Ala Gln Ala Ala Val Arg Ile Ala Ile Asp Met Leu His Glu 
385                 390                 395                 400 

Gly Leu Ile Gln Pro Glu Glu Ala Leu Leu Lys Val Asp Ala Gln His 
                405                 410                 415     

Leu Arg Gln Leu Leu His Arg Arg Leu Gln Gly Thr Asp Ala Leu Gln 
            420                 425                 430         

Val Phe Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ser Val Gly Arg 
        435                 440                 445             

Ile Val Leu Asp Ala Asp Thr Ala Val Glu Trp Ala Gln Arg Gly Glu 
    450                 455                 460                 

Lys Val Val Leu Val Arg Pro Glu Thr Thr Pro Glu Asp Ile His Gly 
465                 470                 475                 480 

Val Leu Ala Ala Glu Gly Val Val Thr Thr His Gly Gly Met Thr Ser 
                485                 490                 495     

His Ala Ala Val Val Ala Arg Gly Ile Gly Lys Pro Ala Val Cys Gly 
            500                 505                 510         

Cys Asp Gly Val His Ile Asp Phe Glu Ala Arg Gln Val Glu Ser Asn 
        515                 520                 525             

Gly Val Val Leu Lys Glu Gly Asp Val Ile Ser Val Asp Gly Gly Thr 
    530                 535                 540                 

Gly Thr Val Tyr Val Gly Glu Ala Gln Met Glu Glu Ala Lys Met Ala 
545                 550                 555                 560 

Asp Glu Leu Lys Glu Leu Leu Ser Ile Ala Asp Gln Val Arg Arg Leu 
                565                 570                 575     

Lys Val Arg Ala Asn Ala Asp Thr Pro Glu Asp Ala Arg Arg Ala Arg 
            580                 585                 590         

Glu Phe Gly Ala Glu Gly Ile Gly Leu Cys Arg Thr Glu His Met Phe 
        595                 600                 605             

Leu Ser Pro Asp Arg Val Pro Leu Val Gln Arg Met Ile Leu Ala Thr 
    610                 615                 620                 

Thr Ser Ala Glu Arg Gln Ala Ala Leu Ser Lys Leu Leu Pro Leu Gln 
625                 630                 635                 640 

Val Ser Asp Phe Thr Ala Ile Phe Glu Ala Met Asp Gly Leu Pro Val 
                645                 650                 655     

Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu Pro Arg Glu 
            660                 665                 670         

Glu Glu Leu Ala Glu Arg Leu Glu Glu Leu Arg Ala Gln Gly Ala Ser 
        675                 680                 685             

Glu Asp Glu Ile Ala Glu Thr Glu Gln Leu Leu Arg Gln Ala Arg Tyr 
    690                 695                 700                 

Leu Arg Glu Ala Asn Pro Met Met Gly Leu Arg Gly Ser Arg Leu Gly 
705                 710                 715                 720 

Ile Val Tyr Pro Glu Ile Tyr Asp Met Gln Met Glu Ala Ile Ile Thr 
                725                 730                 735     

Ala Ala Ala Gln Ala Lys Arg Arg Gly Ile Ala Val Asp Leu Glu Val 
            740                 745                 750         

Met Leu Pro Leu Ile Gly Ser Pro Lys Glu Leu Arg Val Leu Arg Glu 
        755                 760                 765             

Arg Met Glu Glu Ile Ala Lys Arg Thr Met Glu Arg Glu Gly Val Glu 
    770                 775                 780                 

Ile Glu Tyr Arg Ile Gly Thr Met Ile Glu Val Pro Arg Ala Ala Leu 
785                 790                 795                 800 

Thr Ala Asp Gln Ile Ala Glu Asp Ala Gln Phe Phe Ser Phe Gly Thr 
                805                 810                 815     

Asn Asp Leu Thr Gln Met Thr Phe Ala Phe Ser Arg Asp Asp Ala Glu 
            820                 825                 830         

Gly Lys Phe Leu Asn Val Tyr Leu Asp Arg Glu Ile Leu Pro Tyr Asn 
        835                 840                 845             

Pro Phe Glu Thr Leu Asp Thr Glu Gly Val Gly Lys Leu Ile Gln Trp 
    850                 855                 860                 

Ala Val Glu Ala Gly Arg Lys Arg Arg Pro Asp Leu Lys Thr Gly Val 
865                 870                 875                 880 

Cys Gly Glu His Gly Gly Asp Pro Ala Ser Ile Ala Phe Cys Glu Asp 
                885                 890                 895     

Ile Gly Leu Asp Tyr Val Ser Cys Ser Pro Phe Arg Ile Pro Val Ala 
            900                 905                 910         

Arg Ile Ala Ala Ala Gln Ala Ala Val Arg Lys Arg Met Thr Gly 
        915                 920                 925         

<210>   538
<211>   927
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   538
Met Ser His Gly Glu Leu Ala Ala Ser Ala Arg Arg Pro Met Cys Lys 
                5                   10                  15      

Arg Phe Ala Gly Trp Ala Thr Arg Arg Pro Arg Gln Gly Gly Cys Lys 
            20                  25                  30          

Met Ala Gln Val Gln Asp Val Gln Arg Asp Gln Ala Leu Thr Thr Arg 
        35                  40                  45              

Trp Val Tyr Ser Phe Asp Gln Ala Asp Pro Lys Asn Arg Ser Leu Leu 
    50                  55                  60                  

Gly Gly Lys Gly Ala Asn Leu Ala Gln Met Val Gln Trp Gly Phe Pro 
65                  70                  75                  80  

Val Pro Pro Gly Phe Thr Ile Thr Thr Glu Ala Cys Asn Glu Tyr Trp 
                85                  90                  95      

Ala Arg Gly Gly Lys Phe Pro Glu Gly Leu Leu Asp Glu Val Ala Leu 
            100                 105                 110         

Ala Ile Leu Arg Leu Glu Arg Thr Ala Gly Lys Arg Phe Gly Asp Ala 
        115                 120                 125             

Phe Gln Pro Leu Leu Val Ser Val Arg Ser Gly Ala Pro Val Ser Met 
    130                 135                 140                 

Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu Asn Asp Leu Thr 
145                 150                 155                 160 

Val Arg Ala Leu Ala Asn Gln Ser Gln Asp Pro Ala Phe Ala Tyr Asp 
                165                 170                 175     

Ser Tyr Arg Arg Leu Ile Gln Met Phe Ala Asn Val Val Phe Asn Val 
            180                 185                 190         

Ser Leu Glu Pro Phe Glu His Ala Leu Arg Ala Ala Lys Ala Lys His 
        195                 200                 205             

Gly Val Glu Arg Asp Arg Asp Leu Pro Ala Asp Ala Trp Lys Asp Leu 
    210                 215                 220                 

Val Ala Thr Tyr Leu Lys Leu Phe Ala Glu His Val Gly Gln Pro Phe 
225                 230                 235                 240 

Pro Gln Asp Val Asn Val Gln Leu Glu Leu Ala Ile Glu Ala Val Phe 
                245                 250                 255     

Arg Ser Trp Asn Ser Pro Arg Ala Ile Val Tyr Arg Lys Ala His Gly 
            260                 265                 270         

Ile Pro Glu Thr Leu Gly Thr Ala Val Asn Val Gln Ala Met Val Phe 
        275                 280                 285             

Gly Asn Met Gly Asp Asp Ser Gly Thr Gly Val Ile Phe Thr Arg His 
    290                 295                 300                 

Pro Ser Thr Gly Glu Pro Val Leu Phe Gly Glu Phe Leu Ala Asn Ala 
305                 310                 315                 320 

Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Gln Pro Ile Ala 
                325                 330                 335     

Asp Leu Ala His Thr Met Pro His Val Tyr Glu Ser Leu Val Ala Leu 
            340                 345                 350         

Ala Lys Gln Leu Glu Thr Arg Phe Arg Asp Met Gln Asp Val Glu Phe 
        355                 360                 365             

Thr Val Glu Arg Gly Lys Leu Phe Val Leu Gln Thr Arg Ser Gly Lys 
    370                 375                 380                 

Arg Thr Ala Gln Ala Ala Val Arg Ile Ala Ile Asp Met Leu His Glu 
385                 390                 395                 400 

Gly Leu Ile Gln Pro Glu Glu Ala Leu Leu Arg Val Asp Ala Gln His 
                405                 410                 415     

Leu Arg Gln Leu Leu His Arg Arg Leu Gln Gly Thr Asp Ala Leu Gln 
            420                 425                 430         

Val Phe Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ser Val Gly Arg 
        435                 440                 445             

Ile Val Leu Asp Ala Asp Thr Ala Val Glu Trp Ala Gln Arg Gly Glu 
    450                 455                 460                 

Lys Val Val Leu Val Arg Pro Glu Thr Thr Pro Glu Asp Ile His Gly 
465                 470                 475                 480 

Val Leu Ala Ala Glu Gly Val Val Thr Thr His Gly Gly Met Thr Ser 
                485                 490                 495     

His Ala Ala Val Val Ala Arg Gly Ile Gly Lys Pro Ala Val Cys Gly 
            500                 505                 510         

Cys Asp Gly Val His Ile Asp Phe Glu Ala Arg Gln Val Glu Ser Asn 
        515                 520                 525             

Gly Val Val Leu Lys Glu Gly Asp Val Ile Ser Val Asp Gly Gly Thr 
    530                 535                 540                 

Gly Thr Val Tyr Val Gly Glu Ala Gln Met Glu Glu Ala Lys Met Ala 
545                 550                 555                 560 

Asp Glu Leu Lys Glu Leu Leu Ser Ile Ala Asp Gln Val Arg Arg Leu 
                565                 570                 575     

Lys Val Arg Ala Asn Ala Asp Thr Pro Glu Asp Ala Arg Arg Ala Arg 
            580                 585                 590         

Glu Phe Gly Ala Glu Gly Ile Gly Leu Cys Arg Thr Glu His Met Phe 
        595                 600                 605             

Leu Ser Pro Asp Arg Val Pro Leu Val Gln Arg Met Ile Leu Ala Thr 
    610                 615                 620                 

Thr Ser Ala Glu Arg Gln Ala Ala Leu Ser Lys Leu Leu Pro Leu Gln 
625                 630                 635                 640 

Val Ser Asp Phe Thr Ala Ile Phe Glu Ala Met Asp Gly Leu Pro Val 
                645                 650                 655     

Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu Pro Arg Glu 
            660                 665                 670         

Glu Glu Leu Ala Glu Arg Leu Glu Glu Leu Arg Ala Gln Gly Ala Ser 
        675                 680                 685             

Glu Asp Glu Ile Ala Glu Thr Glu Gln Leu Leu Arg Gln Ala Arg Tyr 
    690                 695                 700                 

Leu Arg Glu Ala Asn Pro Met Met Gly Leu Arg Gly Ser Arg Leu Gly 
705                 710                 715                 720 

Ile Val Tyr Pro Glu Ile Tyr Asp Met Gln Met Glu Ala Ile Ile Thr 
                725                 730                 735     

Ala Ala Ala Gln Ala Lys Arg Arg Gly Ile Ala Val Asp Leu Glu Val 
            740                 745                 750         

Met Leu Pro Leu Ile Gly Ser Pro Lys Glu Leu Arg Val Leu Arg Glu 
        755                 760                 765             

Arg Met Glu Glu Leu Ala Lys Arg Thr Met Glu Arg Glu Gly Val Glu 
    770                 775                 780                 

Ile Glu Tyr Arg Ile Gly Thr Met Ile Glu Val Pro Arg Ala Ala Leu 
785                 790                 795                 800 

Thr Ala Asp Gln Ile Ala Glu Asp Ala Gln Phe Phe Ser Phe Gly Thr 
                805                 810                 815     

Asn Asp Leu Thr Gln Met Thr Phe Ala Phe Ser Arg Asp Asp Ala Glu 
            820                 825                 830         

Gly Lys Phe Leu Asn Val Tyr Leu Asp Arg Glu Ile Leu Pro Tyr Asn 
        835                 840                 845             

Pro Phe Glu Thr Leu Asp Thr Glu Gly Val Gly Lys Leu Ile Gln Trp 
    850                 855                 860                 

Ala Val Glu Ala Gly Arg Lys Arg Arg Pro Asp Leu Lys Thr Gly Val 
865                 870                 875                 880 

Cys Gly Glu His Gly Gly Asp Pro Ala Ser Ile Ala Phe Cys Glu Asp 
                885                 890                 895     

Ile Gly Leu Asp Tyr Val Ser Cys Ser Pro Phe Arg Ile Pro Val Ala 
            900                 905                 910         

Arg Ile Ala Ala Ala Gln Ala Ala Val Arg Lys Arg Met Thr Gly 
        915                 920                 925         

<210>   539
<211>   927
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   539
Met Ser His Gly Glu Leu Ala Ala Ser Ala Arg Arg Pro Met Cys Lys 
                5                   10                  15      

Arg Phe Ala Gly Trp Ala Thr Arg Arg Pro Arg Gln Gly Gly Cys Lys 
            20                  25                  30          

Met Ala Gln Val Gln Asp Val Gln Arg Asp Gln Ala Leu Thr Thr Arg 
        35                  40                  45              

Trp Val Tyr Ser Phe Asp Gln Ala Asp Pro Lys Asn Arg Ser Leu Leu 
    50                  55                  60                  

Gly Gly Lys Gly Ala Asn Leu Ala Gln Met Val Gln Trp Gly Phe Pro 
65                  70                  75                  80  

Val Pro Pro Gly Phe Thr Ile Thr Thr Glu Ala Cys Asn Glu Tyr Trp 
                85                  90                  95      

Ala Arg Gly Gly Lys Phe Pro Glu Gly Leu Leu Asp Glu Val Ala Leu 
            100                 105                 110         

Ala Ile Leu Arg Leu Glu Arg Thr Ala Gly Lys Arg Phe Gly Asp Ala 
        115                 120                 125             

Phe Gln Pro Leu Leu Val Ser Val Arg Ser Gly Ala Pro Val Ser Met 
    130                 135                 140                 

Pro Gly Met Met Asp Thr Ile Leu Asn Leu Gly Leu Asn Asp Leu Thr 
145                 150                 155                 160 

Val Arg Ala Leu Ala Asn Gln Ser Gln Asp Pro Ala Phe Ala Tyr Asp 
                165                 170                 175     

Ser Tyr Arg Arg Leu Ile Gln Met Phe Ala Asn Val Val Phe Asn Val 
            180                 185                 190         

Ser Leu Glu Pro Phe Glu His Ala Leu Arg Ala Ala Lys Ala Lys His 
        195                 200                 205             

Gly Val Glu Arg Asp Arg Asp Leu Pro Ala Asp Ala Trp Lys Asp Leu 
    210                 215                 220                 

Val Ala Thr Tyr Leu Lys Leu Phe Ala Glu His Val Gly Gln Pro Phe 
225                 230                 235                 240 

Pro Gln Asp Val Asn Val Gln Leu Glu Leu Ala Ile Glu Ala Val Phe 
                245                 250                 255     

Arg Ser Trp Asn Ser Pro Arg Ala Ile Val Tyr Arg Lys Ala His Gly 
            260                 265                 270         

Ile Pro Glu Thr Leu Gly Thr Ala Val Asn Val Gln Ala Met Val Phe 
        275                 280                 285             

Gly Asn Met Gly Asp Asp Ser Gly Thr Gly Val Ile Phe Thr Arg His 
    290                 295                 300                 

Pro Ser Thr Gly Glu Pro Val Leu Phe Gly Glu Phe Leu Ala Asn Ala 
305                 310                 315                 320 

Gln Gly Glu Asp Val Val Ala Gly Ile Arg Thr Pro Gln Pro Ile Ala 
                325                 330                 335     

Asp Leu Ala His Thr Met Pro His Val Tyr Glu Ser Leu Val Ala Leu 
            340                 345                 350         

Ala Lys Gln Leu Glu Thr Arg Phe Arg Asp Met Gln Asp Val Glu Phe 
        355                 360                 365             

Thr Val Glu Arg Gly Lys Leu Phe Val Leu Gln Thr Arg Ser Gly Lys 
    370                 375                 380                 

Arg Thr Ala Gln Ala Ala Val Arg Ile Ala Ile Asp Met Leu His Glu 
385                 390                 395                 400 

Gly Leu Ile Gln Pro Glu Glu Ala Leu Leu Arg Val Asp Ala Gln His 
                405                 410                 415     

Leu Arg Gln Leu Leu His Arg Arg Leu Gln Gly Thr Asp Ala Leu Gln 
            420                 425                 430         

Val Phe Ala Lys Gly Leu Pro Ala Ser Pro Gly Ala Ser Val Gly Arg 
        435                 440                 445             

Ile Val Leu Asp Ala Asp Thr Ala Val Glu Trp Ala Gln Arg Gly Glu 
    450                 455                 460                 

Lys Val Val Leu Val Arg Pro Glu Thr Thr Pro Glu Asp Ile His Gly 
465                 470                 475                 480 

Val Leu Ala Ala Glu Gly Val Val Thr Thr His Gly Gly Met Thr Ser 
                485                 490                 495     

His Ala Ala Val Val Ala Arg Gly Ile Gly Lys Pro Ala Val Cys Gly 
            500                 505                 510         

Cys Asp Gly Val His Ile Asp Phe Glu Ala Arg Gln Val Glu Ser Asn 
        515                 520                 525             

Gly Val Val Leu Lys Glu Gly Asp Val Ile Ser Val Asp Gly Gly Thr 
    530                 535                 540                 

Gly Thr Val Tyr Val Gly Glu Ala Gln Met Glu Glu Ala Lys Met Ala 
545                 550                 555                 560 

Asp Glu Leu Lys Glu Leu Leu Ser Ile Ala Asp Gln Val Arg Arg Leu 
                565                 570                 575     

Lys Val Arg Ala Asn Ala Asp Thr Pro Glu Asp Ala Arg Arg Ala Arg 
            580                 585                 590         

Glu Phe Gly Ala Glu Gly Ile Gly Leu Cys Arg Thr Glu His Met Phe 
        595                 600                 605             

Leu Ser Pro Asp Arg Val Pro Leu Val Gln Arg Met Ile Leu Ala Thr 
    610                 615                 620                 

Thr Ser Ala Glu Arg Gln Ala Ala Leu Ser Lys Leu Leu Pro Leu Gln 
625                 630                 635                 640 

Val Ser Asp Phe Thr Ala Ile Phe Glu Ala Met Asp Gly Leu Pro Val 
                645                 650                 655     

Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu Pro Arg Glu 
            660                 665                 670         

Glu Glu Leu Ala Glu Arg Leu Glu Glu Leu Arg Ala Asn Gly Ala Ser 
        675                 680                 685             

Glu Asp Glu Ile Ala Glu Thr Glu Gln Leu Leu Arg Gln Ala Arg Tyr 
    690                 695                 700                 

Leu Arg Glu Ala Asn Pro Met Met Gly Leu Arg Gly Ser Arg Leu Gly 
705                 710                 715                 720 

Ile Val Tyr Pro Glu Ile Tyr Asp Met Gln Met Glu Ala Ile Ile Thr 
                725                 730                 735     

Ala Ala Ala Gln Ala Lys Arg Arg Gly Ile Ala Val Asp Leu Glu Val 
            740                 745                 750         

Met Leu Pro Leu Ile Gly Ser Pro Lys Glu Leu Arg Val Leu Arg Glu 
        755                 760                 765             

Arg Met Glu Glu Ile Ala Lys Arg Thr Met Glu Arg Glu Gly Val Glu 
    770                 775                 780                 

Ile Glu Tyr Arg Ile Gly Thr Met Ile Glu Val Pro Arg Ala Ala Leu 
785                 790                 795                 800 

Thr Ala Asp Gln Ile Ala Glu Asp Ala Gln Phe Phe Ser Phe Gly Thr 
                805                 810                 815     

Asn Asp Leu Thr Gln Met Thr Phe Ala Phe Ser Arg Asp Asp Ala Glu 
            820                 825                 830         

Gly Lys Phe Leu Asn Val Tyr Leu Asp Arg Glu Ile Leu Pro Tyr Asn 
        835                 840                 845             

Pro Phe Glu Thr Leu Asp Thr Glu Gly Val Gly Lys Leu Ile Gln Trp 
    850                 855                 860                 

Ala Val Glu Ala Gly Arg Lys Arg Arg Pro Asp Leu Lys Thr Gly Val 
865                 870                 875                 880 

Cys Gly Glu His Gly Gly Asp Pro Ala Ser Ile Ala Phe Cys Glu Asp 
                885                 890                 895     

Ile Gly Leu Asp Tyr Val Ser Cys Ser Pro Phe Arg Ile Pro Val Ala 
            900                 905                 910         

Arg Ile Ala Ala Ala Gln Ala Ala Val Arg Lys Arg Met Thr Gly 
        915                 920                 925         

<210>   540
<211>   2784
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   540
gtgtcacatg gcgagctcgc ggcaagcgca cggcgaccca tgtgcaagcg cttcgccgga       60

tgggcgacac gaaggccgcg acaaggggga tgcaagatgg cgcaggtgca ggatgtacag      120

cgcgatcagg cgctcacgac ccggtgggtc tattcctttg atcaagcaga tccgaaaaac      180

cgaagccttt tgggcggcaa aggcgccaac ttggcgcaga tggttcaatg ggggtttccc      240

gtcccgcctg gctttaccat cacgacggag gcttgcaacg aatattgggc gcggggcggc      300

aagtttcccg aagggctgct ggacgaggtg gcgctcgcca tcctgcggct cgagcgcacg      360

gccgggaagc gattcggcga cgcgtttcag ccgctccttg tttccgtgcg ctccggcgcg      420

cccgtgtcga tgccgggcat gatggacacc attttgaatc tgggcctcaa tgatctgacg      480

gtgcgggcgc tggcgaatca gtcgcaggat cccgcgttcg cctacgactc gtaccgccgc      540

ctgattcaaa tgttcgcaaa cgtggtgttc aacgtatcgc tggagccgtt cgaacacgcg      600

cttagggcgg cgaaggccaa gcacggcgtt gagcgcgatc gcgaccttcc ggccgacgcg      660

tggaaggatc tcgtggcgac gtacctgaaa ctgtttgcag aacacgtcgg acagccgttc      720

ccgcaggacg tgaacgtgca attggaactc gccatcgagg ccgtgttccg ctcgtggaac      780

agcccgcggg ccatcgtcta tcgcaaggct cacggtatcc ctgagaccct cggcacagcg      840

gtcaacgttc aggccatggt gtttggcaac atgggcgacg acagcggcac gggcgtgatc      900

ttcacgcgcc atccgtcgac gggcgagccc gtcttgttcg gcgagttctt ggccaacgct      960

cagggcgagg acgtggtcgc gggcattcgc acgcctcaac ccattgccga tctcgcccac     1020

accatgccgc acgtgtacga gtcgcttgtg gccctcgcga aacagttgga gacgcgcttc     1080

cgggacatgc aggacgtcga gttcacggtg gagcggggca agctgttcgt gctgcagacg     1140

cggagcggga agcgcacggc gcaggcggcc gtccgcatcg ccatcgacat gctgcatgaa     1200

ggcctgattc agccggaaga ggcgctcctg cgcgtcgacg cccagcatct gcgccagctt     1260

ttgcaccggc ggctgcaggg aacggatgca ctgcaggtgt tcgccaaggg gcttccggcg     1320

tctccaggcg cgagcgtggg ccgaattgtg ttggatgcgg acacggcggt ggagtgggcg     1380

cagcgcggcg agaaggtcgt cctcgtgagg cctgagacga cgcccgagga catccacggc     1440

gtgctggccg cggaaggcgt tgtgacgacg cacggtggga tgacgagcca cgcggcggtt     1500

gtggcccgcg gaattggcaa gccggcggtc tgcggctgtg acggcgtgca catcgacttc     1560

gaggcgcgtc aggtcgaatc gaacggcgtc gtgctgaagg aaggtgacgt catctcggtg     1620

gacggcggaa ccgggacggt gtatgtcgga gaggcgcaga tggaagaagc gaaaatggcg     1680

gacgagctga aggagttgct gtccatcgcg gaccaagtgc ggcgcctcaa ggtccgcgcc     1740

aacgcggaca cgccggaaga cgcgcggcgc gcgcgagagt tcggcgctga gggcattggc     1800

ctgtgccgca cggaacacat gttcctgtcg ccggatcggg tgccgctcgt gcagcgcatg     1860

attttggcga ccacgtcggc tgagcgacag gcggccctgt cgaaactgct gccgctccag     1920

gtctcggatt tcaccgccat cttcgaagcg atggacggcc tgccggtgac catacgtctg     1980

ctggatccgc cgctgcacga gttcctgccg cgcgaagagg agctggccga acgcctcgag     2040

gagcttcgcg cgcagggcgc gtccgaggac gagatcgccg agacggaaca gttgctccgg     2100

caagcccgat acctgcggga ggccaacccc atgatgggtc tccgaggttc tcggttgggc     2160

atcgtgtacc ctgagatcta cgatatgcag atggaggcca tcatcacggc cgcggcgcag     2220

gcgaaacgcc gaggcatcgc cgtcgacctg gaagtgatgt tgccgctcat cggctctccg     2280

aaggaacttc gcgttttgcg cgagcgcatg gaggagatcg ctaagcggac gatggagcgc     2340

gagggcgtcg agatcgaata ccgcatcggc acgatgatcg aggtgccgcg cgccgcgctg     2400

acggcggacc agattgcgga ggatgcgcag ttcttctcct tcggcaccaa cgacctgacg     2460

cagatgacgt tcgccttcag ccgagacgac gccgagggga aattcctcaa cgtatacctg     2520

gatcgggaga tcttgcctta caacccgttc gagacgctgg atacggaggg cgtcggcaag     2580

ctgattcaat gggcagtcga agcggggcgc aagcgccgtc ccgatttgaa gaccggcgtg     2640

tgcggcgaac acgggggcga tccggcgtcg attgcgttct gcgaggacat tgggctcgac     2700

tacgtcagct gctcgccctt ccgcatcccg gtcgcgcgga ttgccgcggc gcaggcggcc     2760

gtgcgccgtc gcatgacggg ttga                                            2784


<210>   541
<211>   2784
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   541
gtgtcacatg gcgagctcgc ggcaagcgca cggcgaccca tgtgcaagcg cttcgccgga       60

tgggcgacac gaaggccgcg acaaggggga tgcaagatgg cgcaggtgca ggatgtacag      120

cgcgatcagg cgctcacgac ccggtgggtc tattcctttg atcaagcaga tccgaaaaac      180

cgaagccttt tgggcggcaa aggcgccaac ttggcgcaga tggttcaatg ggggtttccc      240

gtcccgcctg gctttaccat cacgacggag gcttgcaacg aatattgggc gcggggcggc      300

aagtttcccg aagggctgct ggacgaggtg gcgctcgcca tcctgcggct cgagcgcacg      360

gccgggaagc gattcggcga cgcgtttcag ccgctccttg tttccgtgcg ctccggcgcg      420

cccgtgtcga tgccgggcat gatggacacc attttgaatc tgggcctcaa tgatctgacg      480

gtgcgggcgc tggcgaatca gtcgcaggat cccgcgttcg cctacgactc gtaccgccgc      540

ctgattcaaa tgttcgcaaa cgtggtgttc aacgtatcgc tggagccgtt cgaacacgcg      600

cttagggcgg cgaaggccaa gcacggcgtt gagcgcgatc gcgaccttcc ggccgacgcg      660

tggaaggatc tcgtggcgac gtacctgaaa ctgtttgcag aacacgtcgg acagccgttc      720

ccgcaggacg tgaacgtgca attggaactc gccatcgagg ccgtgttccg ctcgtggaac      780

agcccgcggg ccatcgtcta tcgcaaggct cacggtatcc ctgagaccct cggcacagcg      840

gtcaacgttc aggccatggt gtttggcaac atgggcgacg acagcggcac gggcgtgatc      900

ttcacgcgcc atccgtcgac gggcgagccc gtcttgttcg gcgagttctt ggccaacgct      960

cagggcgagg acgtggtcgc gggcattcgc acgcctcaac ccattgccga tctcgcccac     1020

accatgccgc acgtgtacga gtcgcttgtg gccattgcga aacagttgga gacgcgcttc     1080

cgggacatgc aggacgtcga gttcacggtg gagcggggca agctgttcgt gctgcagacg     1140

cggagcggga agcgcacggc gcaggcggcc gtccgcatcg ccatcgacat gctgcatgaa     1200

ggcctgattc agccggaaga ggcgctcctg cgcgtcgacg cccagcatct gcgccagctt     1260

ttgcaccggc ggctgcaggg aacggatgca ctgcaggtgt tcgccaaggg gcttccggcg     1320

tctccaggcg cgagcgtggg ccgaattgtg ttggatgcgg acacggcggt ggagtgggcg     1380

cagcgcggcg agaaggtcgt cctcgtgagg cctgagacga cgcccgagga catccacggc     1440

gtgctggccg cggaaggcgt tgtgacgacg cacggtggga tgacgagcca cgcggcggtt     1500

gtggcccgcg gaattggcaa gccggcggtc tgcggctgtg acggcgtgca catcgacttc     1560

gaggcgcgtc aggtcgaatc gaacggcgtc gtgctgaagg aaggtgacgt catctcggtg     1620

gacggcggaa ccgggacggt gtatgtcgga gaggcgcaga tggaagaagc gaaaatggcg     1680

gacgagctga aggagttgct gtccatcgcg gaccaagtgc ggcgcctcaa ggtccgcgcc     1740

aacgcggaca cgccggaaga cgcgcggcgc gcgcgagagt tcggcgctga gggcattggc     1800

ctgtgccgca cggaacacat gttcctgtcg ccggatcggg tgccgctcgt gcagcgcatg     1860

attttggcga ccacgtcggc tgagcgacag gcggccctgt cgaaactgct gccgctccag     1920

gtctcggatt tcaccgccat cttcgaagcg atggacggcc tgccggtgac catacgtctg     1980

ctggatccgc cgctgcacga gttcctgccg cgcgaagagg agctggccga acgcctcgag     2040

gagcttcgcg cgcagggcgc gtccgaggac gagatcgccg agacggaaca gttgctccgg     2100

caagcccgat acctgcggga ggccaacccc atgatgggtc tccgaggttc tcggttgggc     2160

atcgtgtacc ctgagatcta cgatatgcag atggaggcca tcatcacggc cgcggcgcag     2220

gcgaaacgcc gaggcatcgc cgtcgacctg gaagtgatgt tgccgctcat cggctctccg     2280

aaggaacttc gcgttttgcg cgagcgcatg gaggagatcg ctaagcggac gatggagcgc     2340

gagggcgtcg agatcgaata ccgcatcggc acgatgatcg aggtgccgcg cgccgcgctg     2400

acggcggacc agattgcgga ggatgcgcag ttcttctcct tcggcaccaa cgacctgacg     2460

cagatgacgt tcgccttcag ccgagacgac gccgagggga aattcctcaa cgtatacctg     2520

gatcgggaga tcttgcctta caacccgttc gagacgctgg atacggaggg cgtcggcaag     2580

ctgattcaat gggcagtcga agcggggcgc aagcgccgtc ccgatttgaa gaccggcgtg     2640

tgcggcgaac acgggggcga tccggcgtcg attgcgttct gcgaggacat tgggctcgac     2700

tacgtcagct gctcgccctt ccgcatcccg gtcgcgcgga ttgccgcggc gcaggcggcc     2760

gtgcgcaaac gcatgacggg ttga                                            2784


<210>   542
<211>   2784
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   542
gtgtcacatg gcgagctcgc ggcaagcgca cggcgaccca tgtgcaagcg cttcgccgga       60

tgggcgacac gaaggccgcg acaaggggga tgcaagatgg cgcaggtgca ggatgtacag      120

cgcgatcagg cgctcacgac ccggtgggtc tattcctttg atcaagcaga tccgaaaaac      180

cgaagccttt tgggcggcaa aggcgccaac ttggcgcaga tggttcaatg ggggtttccc      240

gtcccgcctg gctttaccat cacgacggag gcttgcaacg aatattgggc gcggggcggc      300

aagtttcccg aagggctgct ggacgaggtg gcgctcgcca tcctgcggct cgagcgcacg      360

gccgggaagc gattcggcga cgcgtttcag ccgctccttg tttccgtgcg ctccggcgcg      420

cccgtgtcga tgccgggcat gatggacacc attttgaatc tgggcctcaa tgatctgacg      480

gtgcgggcgc tggcgaatca gtcgcaggat cccgcgttcg cctacgactc gtaccgccgc      540

ctgattcaaa tgttcgcaaa cgtggtgttc aacgtatcgc tggagccgtt cgaacacgcg      600

cttagggcgg cgaaggccaa gcacggcgtt gagcgcgatc gcgaccttcc ggccgacgcg      660

tggaaggatc tcgtggcgac gtacctgaaa ctgtttgcag aacacgtcgg acagccgttc      720

ccgcaggacg tgaacgtgca attggaactc gccatcgagg ccgtgttccg ctcgtggaac      780

agcccgcggg ccatcgtcta tcgcaaggct cacggtatcc ctgagaccct cggcacagcg      840

gtcaacgttc aggccatggt gtttggcaac atgggcgacg acagcggcac gggcgtgatc      900

ttcacgcgcc atccgtcgac gggcgagccc gtcttgttcg gcgagttctt ggccaacgct      960

cagggcgagg acgtggtcgc gggcattcgc acgcctcaac ccattgccga tctcgcccac     1020

accatgccgc acgtgtacga gtcgcttgtg gccctcgcga aacagttgga gacgcgcttc     1080

cgggacatgc aggacgtcga gttcacggtg gagcggggca agctgttcgt gctgcagacg     1140

cggagcggga agcgcacggc gcaggcggcc gtccgcatcg ccatcgacat gctgcatgaa     1200

ggcctgattc agccggaaga ggcgctcctg aaagtcgacg cccagcatct gcgccagctt     1260

ttgcaccggc ggctgcaggg aacggatgca ctgcaggtgt tcgccaaggg gcttccggcg     1320

tctccaggcg cgagcgtggg ccgaattgtg ttggatgcgg acacggcggt ggagtgggcg     1380

cagcgcggcg agaaggtcgt cctcgtgagg cctgagacga cgcccgagga catccacggc     1440

gtgctggccg cggaaggcgt tgtgacgacg cacggtggga tgacgagcca cgcggcggtt     1500

gtggcccgcg gaattggcaa gccggcggtc tgcggctgtg acggcgtgca catcgacttc     1560

gaggcgcgtc aggtcgaatc gaacggcgtc gtgctgaagg aaggtgacgt catctcggtg     1620

gacggcggaa ccgggacggt gtatgtcgga gaggcgcaga tggaagaagc gaaaatggcg     1680

gacgagctga aggagttgct gtccatcgcg gaccaagtgc ggcgcctcaa ggtccgcgcc     1740

aacgcggaca cgccggaaga cgcgcggcgc gcgcgagagt tcggcgctga gggcattggc     1800

ctgtgccgca cggaacacat gttcctgtcg ccggatcggg tgccgctcgt gcagcgcatg     1860

attttggcga ccacgtcggc tgagcgacag gcggccctgt cgaaactgct gccgctccag     1920

gtctcggatt tcaccgccat cttcgaagcg atggacggcc tgccggtgac catacgtctg     1980

ctggatccgc cgctgcacga gttcctgccg cgcgaagagg agctggccga acgcctcgag     2040

gagcttcgcg cgcagggcgc gtccgaggac gagatcgccg agacggaaca gttgctccgg     2100

caagcccgat acctgcggga ggccaacccc atgatgggtc tccgaggttc tcggttgggc     2160

atcgtgtacc ctgagatcta cgatatgcag atggaggcca tcatcacggc cgcggcgcag     2220

gcgaaacgcc gaggcatcgc cgtcgacctg gaagtgatgt tgccgctcat cggctctccg     2280

aaggaacttc gcgttttgcg cgagcgcatg gaggagatcg ctaagcggac gatggagcgc     2340

gagggcgtcg agatcgaata ccgcatcggc acgatgatcg aggtgccgcg cgccgcgctg     2400

acggcggacc agattgcgga ggatgcgcag ttcttctcct tcggcaccaa cgacctgacg     2460

cagatgacgt tcgccttcag ccgagacgac gccgagggga aattcctcaa cgtatacctg     2520

gatcgggaga tcttgcctta caacccgttc gagacgctgg atacggaggg cgtcggcaag     2580

ctgattcaat gggcagtcga agcggggcgc aagcgccgtc ccgatttgaa gaccggcgtg     2640

tgcggcgaac acgggggcga tccggcgtcg attgcgttct gcgaggacat tgggctcgac     2700

tacgtcagct gctcgccctt ccgcatcccg gtcgcgcgga ttgccgcggc gcaggcggcc     2760

gtgcgcaaac gcatgacggg ttga                                            2784


<210>   543
<211>   2784
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   543
gtgtcacatg gcgagctcgc ggcaagcgca cggcgaccca tgtgcaagcg cttcgccgga       60

tgggcgacac gaaggccgcg acaaggggga tgcaagatgg cgcaggtgca ggatgtacag      120

cgcgatcagg cgctcacgac ccggtgggtc tattcctttg atcaagcaga tccgaaaaac      180

cgaagccttt tgggcggcaa aggcgccaac ttggcgcaga tggttcaatg ggggtttccc      240

gtcccgcctg gctttaccat cacgacggag gcttgcaacg aatattgggc gcggggcggc      300

aagtttcccg aagggctgct ggacgaggtg gcgctcgcca tcctgcggct cgagcgcacg      360

gccgggaagc gattcggcga cgcgtttcag ccgctccttg tttccgtgcg ctccggcgcg      420

cccgtgtcga tgccgggcat gatggacacc attttgaatc tgggcctcaa tgatctgacg      480

gtgcgggcgc tggcgaatca gtcgcaggat cccgcgttcg cctacgactc gtaccgccgc      540

ctgattcaaa tgttcgcaaa cgtggtgttc aacgtatcgc tggagccgtt cgaacacgcg      600

cttagggcgg cgaaggccaa gcacggcgtt gagcgcgatc gcgaccttcc ggccgacgcg      660

tggaaggatc tcgtggcgac gtacctgaaa ctgtttgcag aacacgtcgg acagccgttc      720

ccgcaggacg tgaacgtgca attggaactc gccatcgagg ccgtgttccg ctcgtggaac      780

agcccgcggg ccatcgtcta tcgcaaggct cacggtatcc ctgagaccct cggcacagcg      840

gtcaacgttc aggccatggt gtttggcaac atgggcgacg acagcggcac gggcgtgatc      900

ttcacgcgcc atccgtcgac gggcgagccc gtcttgttcg gcgagttctt ggccaacgct      960

cagggcgagg acgtggtcgc gggcattcgc acgcctcaac ccattgccga tctcgcccac     1020

accatgccgc acgtgtacga gtcgcttgtg gccctcgcga aacagttgga gacgcgcttc     1080

cgggacatgc aggacgtcga gttcacggtg gagcggggca agctgttcgt gctgcagacg     1140

cggagcggga agcgcacggc gcaggcggcc gtccgcatcg ccatcgacat gctgcatgaa     1200

ggcctgattc agccggaaga ggcgctcctg cgcgtcgacg cccagcatct gcgccagctt     1260

ttgcaccggc ggctgcaggg aacggatgca ctgcaggtgt tcgccaaggg gcttccggcg     1320

tctccaggcg cgagcgtggg ccgaattgtg ttggatgcgg acacggcggt ggagtgggcg     1380

cagcgcggcg agaaggtcgt cctcgtgagg cctgagacga cgcccgagga catccacggc     1440

gtgctggccg cggaaggcgt tgtgacgacg cacggtggga tgacgagcca cgcggcggtt     1500

gtggcccgcg gaattggcaa gccggcggtc tgcggctgtg acggcgtgca catcgacttc     1560

gaggcgcgtc aggtcgaatc gaacggcgtc gtgctgaagg aaggtgacgt catctcggtg     1620

gacggcggaa ccgggacggt gtatgtcgga gaggcgcaga tggaagaagc gaaaatggcg     1680

gacgagctga aggagttgct gtccatcgcg gaccaagtgc ggcgcctcaa ggtccgcgcc     1740

aacgcggaca cgccggaaga cgcgcggcgc gcgcgagagt tcggcgctga gggcattggc     1800

ctgtgccgca cggaacacat gttcctgtcg ccggatcggg tgccgctcgt gcagcgcatg     1860

attttggcga ccacgtcggc tgagcgacag gcggccctgt cgaaactgct gccgctccag     1920

gtctcggatt tcaccgccat cttcgaagcg atggacggcc tgccggtgac catacgtctg     1980

ctggatccgc cgctgcacga gttcctgccg cgcgaagagg agctggccga acgcctcgag     2040

gagcttcgcg cgcagggcgc gtccgaggac gagatcgccg agacggaaca gttgctccgg     2100

caagcccgat acctgcggga ggccaacccc atgatgggtc tccgaggttc tcggttgggc     2160

atcgtgtacc ctgagatcta cgatatgcag atggaggcca tcatcacggc cgcggcgcag     2220

gcgaaacgcc gaggcatcgc cgtcgacctg gaagtgatgt tgccgctcat cggctctccg     2280

aaggaacttc gcgttttgcg cgagcgcatg gaggagttag ctaagcggac gatggagcgc     2340

gagggcgtcg agatcgaata ccgcatcggc acgatgatcg aggtgccgcg cgccgcgctg     2400

acggcggacc agattgcgga ggatgcgcag ttcttctcct tcggcaccaa cgacctgacg     2460

cagatgacgt tcgccttcag ccgagacgac gccgagggga aattcctcaa cgtatacctg     2520

gatcgggaga tcttgcctta caacccgttc gagacgctgg atacggaggg cgtcggcaag     2580

ctgattcaat gggcagtcga agcggggcgc aagcgccgtc ccgatttgaa gaccggcgtg     2640

tgcggcgaac acgggggcga tccggcgtcg attgcgttct gcgaggacat tgggctcgac     2700

tacgtcagct gctcgccctt ccgcatcccg gtcgcgcgga ttgccgcggc gcaggcggcc     2760

gtgcgcaaac gcatgacggg ttga                                            2784


<210>   544
<211>   2784
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   544
gtgtcacatg gcgagctcgc ggcaagcgca cggcgaccca tgtgcaagcg cttcgccgga       60

tgggcgacac gaaggccgcg acaaggggga tgcaagatgg cgcaggtgca ggatgtacag      120

cgcgatcagg cgctcacgac ccggtgggtc tattcctttg atcaagcaga tccgaaaaac      180

cgaagccttt tgggcggcaa aggcgccaac ttggcgcaga tggttcaatg ggggtttccc      240

gtcccgcctg gctttaccat cacgacggag gcttgcaacg aatattgggc gcggggcggc      300

aagtttcccg aagggctgct ggacgaggtg gcgctcgcca tcctgcggct cgagcgcacg      360

gccgggaagc gattcggcga cgcgtttcag ccgctccttg tttccgtgcg ctccggcgcg      420

cccgtgtcga tgccgggcat gatggacacc attttgaatc tgggcctcaa tgatctgacg      480

gtgcgggcgc tggcgaatca gtcgcaggat cccgcgttcg cctacgactc gtaccgccgc      540

ctgattcaaa tgttcgcaaa cgtggtgttc aacgtatcgc tggagccgtt cgaacacgcg      600

cttagggcgg cgaaggccaa gcacggcgtt gagcgcgatc gcgaccttcc ggccgacgcg      660

tggaaggatc tcgtggcgac gtacctgaaa ctgtttgcag aacacgtcgg acagccgttc      720

ccgcaggacg tgaacgtgca attggaactc gccatcgagg ccgtgttccg ctcgtggaac      780

agcccgcggg ccatcgtcta tcgcaaggct cacggtatcc ctgagaccct cggcacagcg      840

gtcaacgttc aggccatggt gtttggcaac atgggcgacg acagcggcac gggcgtgatc      900

ttcacgcgcc atccgtcgac gggcgagccc gtcttgttcg gcgagttctt ggccaacgct      960

cagggcgagg acgtggtcgc gggcattcgc acgcctcaac ccattgccga tctcgcccac     1020

accatgccgc acgtgtacga gtcgcttgtg gccctcgcga aacagttgga gacgcgcttc     1080

cgggacatgc aggacgtcga gttcacggtg gagcggggca agctgttcgt gctgcagacg     1140

cggagcggga agcgcacggc gcaggcggcc gtccgcatcg ccatcgacat gctgcatgaa     1200

ggcctgattc agccggaaga ggcgctcctg cgcgtcgacg cccagcatct gcgccagctt     1260

ttgcaccggc ggctgcaggg aacggatgca ctgcaggtgt tcgccaaggg gcttccggcg     1320

tctccaggcg cgagcgtggg ccgaattgtg ttggatgcgg acacggcggt ggagtgggcg     1380

cagcgcggcg agaaggtcgt cctcgtgagg cctgagacga cgcccgagga catccacggc     1440

gtgctggccg cggaaggcgt tgtgacgacg cacggtggga tgacgagcca cgcggcggtt     1500

gtggcccgcg gaattggcaa gccggcggtc tgcggctgtg acggcgtgca catcgacttc     1560

gaggcgcgtc aggtcgaatc gaacggcgtc gtgctgaagg aaggtgacgt catctcggtg     1620

gacggcggaa ccgggacggt gtatgtcgga gaggcgcaga tggaagaagc gaaaatggcg     1680

gacgagctga aggagttgct gtccatcgcg gaccaagtgc ggcgcctcaa ggtccgcgcc     1740

aacgcggaca cgccggaaga cgcgcggcgc gcgcgagagt tcggcgctga gggcattggc     1800

ctgtgccgca cggaacacat gttcctgtcg ccggatcggg tgccgctcgt gcagcgcatg     1860

attttggcga ccacgtcggc tgagcgacag gcggccctgt cgaaactgct gccgctccag     1920

gtctcggatt tcaccgccat cttcgaagcg atggacggcc tgccggtgac catacgtctg     1980

ctggatccgc cgctgcacga gttcctgccg cgcgaagagg agctggccga acgcctcgag     2040

gagcttcgcg cgaatggcgc gtccgaggac gagatcgccg agacggaaca gttgctccgg     2100

caagcccgat acctgcggga ggccaacccc atgatgggtc tccgaggttc tcggttgggc     2160

atcgtgtacc ctgagatcta cgatatgcag atggaggcca tcatcacggc cgcggcgcag     2220

gcgaaacgcc gaggcatcgc cgtcgacctg gaagtgatgt tgccgctcat cggctctccg     2280

aaggaacttc gcgttttgcg cgagcgcatg gaggagatcg ctaagcggac gatggagcgc     2340

gagggcgtcg agatcgaata ccgcatcggc acgatgatcg aggtgccgcg cgccgcgctg     2400

acggcggacc agattgcgga ggatgcgcag ttcttctcct tcggcaccaa cgacctgacg     2460

cagatgacgt tcgccttcag ccgagacgac gccgagggga aattcctcaa cgtatacctg     2520

gatcgggaga tcttgcctta caacccgttc gagacgctgg atacggaggg cgtcggcaag     2580

ctgattcaat gggcagtcga agcggggcgc aagcgccgtc ccgatttgaa gaccggcgtg     2640

tgcggcgaac acgggggcga tccggcgtcg attgcgttct gcgaggacat tgggctcgac     2700

tacgtcagct gctcgccctt ccgcatcccg gtcgcgcgga ttgccgcggc gcaggcggcc     2760

gtgcgcaaac gcatgacggg ttga                                            2784


<210>   545
<211>   797
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   545
Met Arg Gln Ile Arg Arg Ala Ala Val Ile Gly Ser Gly Val Met Gly 
                5                   10                  15      

Ala Gln Ile Ala Ala His Leu Ala Asn Val Gly Ile Pro Ser Leu Leu 
            20                  25                  30          

Leu Asp Leu Val Pro Gln Glu Leu Thr Ala Glu Glu Gln Lys Lys Gly 
        35                  40                  45              

Leu Ser Leu Asp His Pro Ala Val Arg Asn Arg Leu Ala Thr Glu Ala 
    50                  55                  60                  

Ile Arg Arg Leu Asn Lys Leu Ser Pro Ala Pro Leu Phe Arg Ala Asp 
65                  70                  75                  80  

Tyr Ala Lys Leu Ile Thr Pro Gly Asn Leu Glu Asp Asp Leu His Arg 
                85                  90                  95      

Ile Cys Glu Val Asp Trp Val Ile Glu Val Ile Val Glu Ser Leu Glu 
            100                 105                 110         

Pro Lys Arg Gln Leu Leu Glu Arg Ile Glu Arg Tyr Trp His Glu Gly 
        115                 120                 125             

Met Ile Val Ser Thr Asn Thr Ser Gly Ile Ser Ile Asn Ala Met Val 
    130                 135                 140                 

Glu Gly Arg Ser Glu Ala Phe Arg Arg His Phe Leu Gly Thr His Phe 
145                 150                 155                 160 

Phe Asn Pro Pro Arg Tyr Met Lys Leu Leu Glu Val Ile Pro Gly Arg 
                165                 170                 175     

Asp Thr Asp Pro Ala Ile Val Glu Phe Met Arg Asp Phe Gly Thr Glu 
            180                 185                 190         

Arg Leu Gly Lys Gly Val Val Leu Ala Lys Asp Thr Pro Asn Phe Ile 
        195                 200                 205             

Ala Asn Arg Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Glu Glu Met 
    210                 215                 220                 

Gln Lys Gly Gly Phe Thr Val Glu Glu Val Asp Ala Ile Thr Gly Pro 
225                 230                 235                 240 

Ala Leu Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Leu Val 
                245                 250                 255     

Gly Ile Asp Thr Phe Val His Val Ala Asn Asn Val Arg Gln Asn Val 
            260                 265                 270         

Thr Asp Pro Gln Glu Gln Arg Ala Phe Glu Val Pro Glu Ala Ile Gln 
        275                 280                 285             

Lys Leu Val Glu Arg Gly Trp Leu Gly Glu Lys Ser Gly Gln Gly Phe 
    290                 295                 300                 

Tyr Lys Arg Val Lys Gln Asn Gly Gln Arg Gln Ile Leu Val Leu Asp 
305                 310                 315                 320 

Leu Asp Thr Phe Glu Tyr Arg Glu Gln Lys Lys Ile Ala Ser Ser Ala 
                325                 330                 335     

Leu Glu Ala Ser Lys Gln Ala Lys Gly Ala Ala Gly Lys Ala Lys Ala 
            340                 345                 350         

Leu Leu Gln Gly Gly Asp Arg Tyr Ala Glu Leu Ala Trp Asn Ile Val 
        355                 360                 365             

Lys Arg Val Leu Val Tyr Ser Ala Glu Lys Leu Gly Glu Ile Ala Asp 
    370                 375                 380                 

Thr Ile Gln Asp Ile Asp Ala Ala Met Arg Trp Gly Phe Asn Trp Glu 
385                 390                 395                 400 

Leu Gly Pro Phe Glu Leu Trp Asp Ala Leu Gly Leu Val Glu Thr Ala 
                405                 410                 415     

Glu Arg Met Arg Ala Glu Gly Leu Arg Leu Pro Ser Trp Val Glu Asp 
            420                 425                 430         

Trp Ile Ala Ala Gly His Arg Ala Phe Tyr Glu Glu Lys Asp Gly Lys 
        435                 440                 445             

Leu Thr Met Pro Val Asn Gly Lys Pro Glu Pro Val Arg Val Pro Ala 
    450                 455                 460                 

Gly Val Ile Asp Leu Ala Ala Leu Lys Lys Ala Gly Lys Val Ile Ala 
465                 470                 475                 480 

Gln Asn Thr Gly Ala Ser Leu Ile Asp Leu Gly Asp Gly Val Ala Cys 
                485                 490                 495     

Leu Glu Phe His Ser Gln Asn Asn Ala Ile Gly Pro Asp Ile Leu Thr 
            500                 505                 510         

Met Ile Glu Lys Ser Val Ala Ile Ala Glu Lys Asp Phe Ala Gly Leu 
        515                 520                 525             

Val Ile Ala Asn Gln Gly Lys Asn Phe Cys Val Gly Ala Asn Leu Met 
    530                 535                 540                 

Leu Ile Leu Met Ala Ala Gln Glu Gly Asp Trp Asp Glu Ile Asp Leu 
545                 550                 555                 560 

Ser Ile Arg Gln Phe His Arg Ala Met Leu Ala Leu Arg Tyr Ser Gln 
                565                 570                 575     

Val Pro Val Val Ala Ala Pro His Arg Met Thr Leu Gly Gly Gly Val 
            580                 585                 590         

Glu Val Cys Leu Ala Ser Ser Arg Val Leu Pro Ala Ala Glu Thr Tyr 
        595                 600                 605             

Phe Gly Leu Val Glu Val Gly Val Gly Val Ile Pro Gly Gly Gly Gly 
    610                 615                 620                 

Cys Lys Glu Thr Ala Arg Arg Val Ala Glu Ser Val Gly Pro Glu Asp 
625                 630                 635                 640 

Asp Leu Val Pro Ala Leu Ala Arg Met Phe Gln Ala Ile Gly Thr Ala 
                645                 650                 655     

Lys Val Ser Thr Ser Gly Ala Glu Ala Leu Ala Met Gly Trp Leu Arg 
            660                 665                 670         

Glu Thr Asp Arg Val Val Val Asn Asp Asp Leu Arg Ile Ser Ala Ala 
        675                 680                 685             

Lys Ala Glu Val Leu Arg Met Ala Glu Ile Gly Tyr Thr Ala Pro Pro 
    690                 695                 700                 

Lys Ala Lys Glu Ile Arg Val Ala Gly Arg Asp Gly Lys Ala Thr Leu 
705                 710                 715                 720 

Gln Met Ala Ala Arg Ser Met Trp Asn Gly Gly Tyr Ile Thr Asp Tyr 
                725                 730                 735     

Asp Leu His Ile Ala Tyr Lys Leu Ala His Val Leu Ala Gly Gly Asp 
            740                 745                 750         

Val Pro Ala Gly Ser Leu Val Ser Glu Asp Tyr Leu Leu Asp Leu Glu 
        755                 760                 765             

Arg Glu Ala Phe Leu Ser Leu Cys Gly Glu Pro Lys Thr Ile Gln Arg 
    770                 775                 780                 

Met Gln His Met Leu Ala Thr Gly Lys Pro Leu Arg Asn 
785                 790                 795         

<210>   546
<211>   2394
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   546
atgagacaaa ttcgccgagc tgccgtcatt ggttccggcg tgatgggggc gcaaattgcc       60

gctcatctcg ccaacgtggg cattccgagc ctgctgttgg acctcgttcc gcaagagttg      120

actgcggaag aacaaaagaa aggtttgtcg ctcgatcacc cagcggttcg caaccgcctg      180

gcgacggagg ccatccgtag gctgaacaag ctcagcccgg cgcccttgtt ccgcgccgac      240

tacgcgaaac tcatcacgcc tggaaacctc gaggacgacc tgcatcggat ctgcgaggtc      300

gactgggtga ttgaggtcat cgtggagagc ctcgagccca agcgccaact gctcgagcgc      360

atcgagcgat actggcacga gggcatgatt gtgagcacca acacgtcggg catctccatc      420

aacgcgatgg tcgaggggcg aagcgaggcg ttccgccgac acttcctcgg cacgcacttc      480

ttcaatcctc cgcgctacat gaagctgttg gaggtcattc ctggccggga tacggatccc      540

gccatcgtgg agttcatgcg cgactttgga acggagcgcc tcggcaaagg cgtggtgttg      600

gcgaaagaca cgccgaactt catcgccaat cgcatcggca cctacggcct cttggtgacc      660

gtggaggaga tgcaaaaggg cggcttcacc gttgaggagg tcgacgccat caccggtccg      720

gccctcgggc gcccgaagag cgcgaccttc cgcacgctgg atctcgtcgg gatcgacacg      780

tttgtccacg tggccaacaa cgtgcgtcag aacgtgaccg atccacagga acagcgggcg      840

tttgaggtgc cagaggccat ccagaagctc gtggagcgcg gatggctcgg cgagaagagc      900

ggacaaggct tttataagcg cgtgaagcaa aacggccagc gccagatcct cgtgctcgat      960

ctcgacacgt tcgagtaccg cgagcaaaag aagatcgctt cgtcggcgct cgaggcctcg     1020

aagcaggcca aaggggcggc cggaaaggcg aaggcgctcc tccagggcgg cgatcggtac     1080

gcagaactcg cgtggaacat cgtcaagcgc gtgctcgtgt actcggccga gaaactgggc     1140

gagatcgcgg acacgattca ggacatcgac gccgcgatgc gctggggatt caactgggag     1200

ctcgggccgt ttgaactctg ggacgcgctc gggctggtgg agactgccga gcggatgcgc     1260

gcggaagggc tcaggctgcc ctcatgggtc gaggactgga ttgctgcggg gcatcgcgcc     1320

ttctacgaag agaaagacgg caagctgacc atgccggtga acggcaagcc tgagcctgtt     1380

cgggtgccgg ctggggtgat cgatctcgcc gcgctgaaga aggcaggcaa ggtcatcgcg     1440

cagaacaccg gcgcgagcct catcgacctg ggcgacgggg tcgcgtgcct ggagttccat     1500

tcgcagaaca acgccattgg ccccgacatt ctgacgatga tcgaaaagag cgtggccatc     1560

gcggagaaag acttcgcggg cctggtcatc gcgaaccagg gcaagaactt ctgcgtcggc     1620

gcgaacctca tgctcatcct gatggcagcg caggagggcg actgggacga aattgatctc     1680

tccatccgcc agttccaccg cgccatgctt gcgcttcgct acagccaagt gccggtggtg     1740

gcggcgcctc atcggatgac gctcggcggc ggcgtcgaag tgtgcctggc gtcgtcgagg     1800

gtgctgccgg ccgcggagac ctatttcggg ttggtcgagg tgggcgtcgg cgtcattccg     1860

ggcggcggcg gctgcaagga gacggcgcgc cgcgtggcgg aatcggtcgg ccccgaagac     1920

gatctcgtcc ccgctctagc ccgcatgttc caggccatcg gcaccgccaa ggtgtcgacg     1980

agtggcgccg aggccctggc gatgggctgg ctgcgcgaga cggatcgcgt ggtggtgaac     2040

gacgacctgc gcatctcggc cgcgaaggcg gaggtgcttc gcatggctga gattggctac     2100

accgcgccgc cgaaggcgaa ggaaattcgc gtcgcgggcc gcgacggcaa ggcgaccttg     2160

cagatggccg cgcgcagcat gtggaacggt ggctacatca cggattacga cctccacatc     2220

gcctacaagc tcgcgcatgt gctggcgggc ggcgacgtgc cggcgggctc cctcgtgagc     2280

gaggactacc tgctcgatct cgagcgcgag gcgttcctca gcctgtgcgg agagccgaag     2340

accatccagc gcatgcagca catgctcgcc accgggaagc cgcttcgcaa ctga           2394


<210>   547
<211>   794
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   547
Val Lys Arg Ile Arg Arg Ala Ala Val Leu Gly Ser Gly Val Met Gly 
                5                   10                  15      

Ser Gly Ile Ala Ala His Leu Ala Asn Val Gly Ile Pro Thr Leu Leu 
            20                  25                  30          

Leu Asp Ile Val Pro Arg Glu Leu Thr Lys Glu Glu Glu Ala Lys Gly 
        35                  40                  45              

Trp Thr Leu Glu His Lys Gln Val Arg Asn Arg Leu Ala Asn Gln Ala 
    50                  55                  60                  

Leu Glu Arg Leu Leu Lys Gln Lys Pro Ala Pro Leu Met Ser Lys Asp 
65                  70                  75                  80  

Asn Ile Ala Leu Ile Glu Thr Gly Asn Phe Glu Asp Asp Phe His Arg 
                85                  90                  95      

Leu Ala Glu Val Asp Trp Ile Ile Glu Ala Val Val Glu Lys Leu Glu 
            100                 105                 110         

Val Lys Lys Glu Val Phe Ala Arg Val Asp Glu Val Arg Thr Pro Gly 
        115                 120                 125             

Thr Ile Val Ser Ser Asn Thr Ser Gly Ile Ser Ile Ala Ala Met Ala 
    130                 135                 140                 

Glu Gly Arg Ser Asp Asp Phe Lys Lys His Phe Leu Gly Thr His Phe 
145                 150                 155                 160 

Phe Asn Pro Pro Arg Tyr Leu Lys Leu Leu Glu Ile Ile Pro Thr Glu 
                165                 170                 175     

His Thr Asp Pro Asp Val Val Ala Tyr Met Lys Ser Phe Gly Glu Asp 
            180                 185                 190         

Val Leu Gly Lys Gly Val Val Met Ala Lys Asp Thr Pro Asn Phe Ile 
        195                 200                 205             

Ala Asn Arg Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Arg Glu Met 
    210                 215                 220                 

Met Gln Gly Gly Tyr Ser Val Gly Glu Val Asp Ser Val Thr Gly Pro 
225                 230                 235                 240 

Leu Ile Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Val Val 
                245                 250                 255     

Gly Leu Asp Thr Phe Val His Val Ala Asn Asn Val Tyr Glu Asn Val 
            260                 265                 270         

Glu Gly Glu Glu Lys Glu Ala Phe Arg Val Pro Glu Phe Met Lys Thr 
        275                 280                 285             

Met Leu Glu Asn Gly Trp Leu Gly Ser Lys Ser Gly Gln Gly Phe Phe 
    290                 295                 300                 

Val Lys Gln Gly Lys Asp Ile Leu Glu Leu Asn Tyr Val Thr Met Gln 
305                 310                 315                 320 

Tyr Glu Pro Arg Lys Lys Leu Val Thr Pro Ala Val Glu Met Ala Lys 
                325                 330                 335     

Gln Ala Lys Gly Ala Ala Ala Lys Leu Gln Thr Leu Val Tyr Ala Asp 
            340                 345                 350         

Gly Asp Arg Ala Gly Thr Leu Leu Trp Asn Ile Ile Ala Pro Thr Leu 
        355                 360                 365             

Leu Tyr Thr Ala Arg Leu Val Gly Glu Ile Ala Asp Asp Ile Ala Ala 
    370                 375                 380                 

Ile Asp Gln Ala Met Lys Trp Gly Phe Gly Trp Glu Gln Gly Pro Phe 
385                 390                 395                 400 

Glu Leu Trp Asp Ala Ile Gly Leu Glu Lys Ser Val Arg Lys Met Gln 
                405                 410                 415     

Ser Glu Gly Arg Asp Ile Pro Ser Trp Ile Thr Asp Met Leu Ala Asp 
            420                 425                 430         

Gly Ala Thr Ser Phe Tyr Lys Thr Glu Asn Gly Arg Leu Phe Tyr Tyr 
        435                 440                 445             

Ala Pro Gly Gly Tyr Lys Thr Val Glu Glu Asn Glu Lys Val Ile His 
    450                 455                 460                 

Ile Arg Arg Leu Lys Glu Ala Arg Gly Val Ile Lys Lys Asn Ala Gly 
465                 470                 475                 480 

Ala Ser Leu Ile Asp Leu Gly Asp Asp Val Ala Leu Leu Glu Phe His 
                485                 490                 495     

Ser Pro Asn Asn Ala Ile Gly Ala Asp Ile Val Gln Met Ile Asn Glu 
            500                 505                 510         

Ala Leu Glu Glu Val Asn Arg Asn Tyr Lys Gly Leu Val Ile Gly Asn 
        515                 520                 525             

Gln Gly Lys Asn Phe Cys Val Gly Ala Asn Leu Ala Met Met Leu Met 
    530                 535                 540                 

Glu Ala Gln Asp Glu Asn Phe Phe Glu Leu Glu Leu Ala Val Arg Gln 
545                 550                 555                 560 

Phe Gln Gln Ala Leu Leu Lys Met Lys Tyr Asn Pro Lys Pro Val Val 
                565                 570                 575     

Val Ala Pro Phe Ala Met Thr Leu Gly Gly Gly Ala Glu Val Ser Leu 
            580                 585                 590         

Ala Ala Ser Arg Ile Gln Ala Ala Ala Glu Thr Tyr Ile Gly Leu Val 
        595                 600                 605             

Glu Val Gly Val Gly Leu Ile Pro Gly Gly Gly Gly Asn Lys Glu Leu 
    610                 615                 620                 

Tyr Ile Lys Arg Leu Asn Ser Leu Pro Arg Gly Val Asp Val Asp Tyr 
625                 630                 635                 640 

Val Lys Ile Ala Ala Ser Val Phe Glu Thr Ile Ala Met Ala Lys Val 
                645                 650                 655     

Ser Thr Ser Ala Ala Glu Ala Arg Glu Leu Gly Phe Leu Asn His Arg 
            660                 665                 670         

Asp Gly Ile Thr Met Asn Gly Asp His Leu Leu Tyr Glu Ala Lys Gln 
        675                 680                 685             

Ala Val Leu Ser Met Tyr Glu Glu Gly Tyr Arg Pro Pro Val Arg Lys 
    690                 695                 700                 

Lys Val Pro Val Ala Gly Glu Ser Gly Tyr Ala Ala Met Leu Leu Gly 
705                 710                 715                 720 

Ala Gln Ser Met Phe His Ser Gly Tyr Ile Ser Glu His Asp Leu Lys 
                725                 730                 735     

Ile Ala Lys Lys Leu Ala Tyr Val Leu Ala Gly Gly Lys Val Pro Tyr 
            740                 745                 750         

Gly Thr Glu Val Asp Glu Gln Tyr Leu Leu Asp Leu Glu Arg Glu Ala 
        755                 760                 765             

Phe Leu Ser Leu Ile Gly Glu Pro Lys Thr Gln Ala Arg Met Gln His 
    770                 775                 780                 

Met Leu Val Lys Gly Lys Pro Leu Arg Asn 
785                 790                 

<210>   548
<211>   790
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   548
Ile Arg Lys Ala Ala Val Leu Gly Ala Gly Val Met Gly Ala Gln Ile 
                5                   10                  15      

Ala Ala His Leu Ala Asn Val Gly Ile Pro Thr Leu Leu Leu Asp Ile 
            20                  25                  30          

Val Pro Arg Glu Leu Thr Pro Asp Glu Ala Lys Lys Gly Leu Thr Leu 
        35                  40                  45              

Glu Ser Pro Ala Val Arg Asn Arg Leu Ala Ala Ser Ala Leu Gln Asn 
    50                  55                  60                  

Leu Gln Lys Leu Lys Pro Ser Pro Leu Tyr Ser Lys Asp Val Leu Arg 
65                  70                  75                  80  

Leu Ile Thr Pro Gly Asn Leu Glu Asp Asp Leu Ala Lys Val Ala Glu 
                85                  90                  95      

Cys Asp Trp Val Val Glu Ala Val Ile Glu Asn Leu Gln Ile Lys Lys 
            100                 105                 110         

Asp Leu Trp Gln Arg Val Ala Ala His His Arg Pro Gly Met Ile Cys 
        115                 120                 125             

Ser Ser Asn Thr Ser Gly Ile Ser Ile Gln Ala Met Val Glu Gly Thr 
    130                 135                 140                 

Pro Glu Ser Phe Arg Arg His Phe Leu Gly Thr His Phe Phe Asn Pro 
145                 150                 155                 160 

Pro Arg Tyr Met Lys Leu Leu Glu Ile Ile Pro Thr Pro Asp Thr Asp 
                165                 170                 175     

Pro Glu Val Val Ala Phe Met Ala Asp Phe Gly Glu Arg Val Leu Gly 
            180                 185                 190         

Lys Gly Val Val Met Ala Lys Asp Thr Pro Asn Phe Ile Gly Asn Arg 
        195                 200                 205             

Ile Gly Val Tyr Gly Met Met Val Thr Leu Glu Glu Met Asn Arg Leu 
    210                 215                 220                 

Gly Leu Thr Pro Asp Glu Val Asp Ala Leu Thr Gly Lys Ala Ile Gly 
225                 230                 235                 240 

Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Val Val Gly Ile Asp 
                245                 250                 255     

Thr Phe Cys His Val Ala Asp Asn Cys Arg Ala Thr Ile Pro Asp Pro 
            260                 265                 270         

Glu Glu Ala Lys Ile Phe Val Val Pro Glu Pro Ile Arg Glu Met Val 
        275                 280                 285             

Lys Arg Gly Trp Val Gly Gln Lys Ala Arg Gln Gly Phe Phe Lys Lys 
    290                 295                 300                 

Glu Gly Asp Gln Ile Leu Thr Leu Asp Leu Glu Thr Met Glu Tyr Arg 
305                 310                 315                 320 

Pro Arg Arg Lys Ala Ser Phe Pro Ser Leu Glu Ala Ala Lys Ala Asn 
                325                 330                 335     

Pro Asp Leu Arg Ser Arg Val Arg Gly Leu Val Phe Ala Lys Asp Lys 
            340                 345                 350         

Ala Gly Glu Phe Leu Trp Ala Ile Thr Lys Arg Thr Leu Leu Tyr Ala 
        355                 360                 365             

Ala Arg Lys Val Gly Glu Ile Ala Asp Asp Val Val Ala Ile Asp Asn 
    370                 375                 380                 

Ala Met Lys Trp Gly Tyr Asn Trp Glu Leu Gly Pro Phe Glu Met Trp 
385                 390                 395                 400 

Asp Ala Ile Gly Leu Pro Glu Ser Ile Ala Arg Met Glu Ala Glu Gly 
                405                 410                 415     

Glu Ala Val Pro Asp Trp Val Lys Glu Ala Ala Arg Lys Gly Gly Phe 
            420                 425                 430         

Tyr Arg Arg Glu Ala Gly Lys Ser Phe Phe Ile Asn Lys Gly Glu Tyr 
        435                 440                 445             

Ala Pro Val Pro Val Ser Asp Arg Val Ile Asp Ile Gly Ala Leu Arg 
    450                 455                 460                 

Glu Thr Gly Arg Val Val Arg Glu Lys Lys Gly Ala Thr Leu Leu Asp 
465                 470                 475                 480 

Met Gly Asp Gly Val Leu Leu Met Glu Thr His Ser Pro Lys Ala Ala 
                485                 490                 495     

Ile Gly Phe Asp Ile Ile Asn Met Cys Lys Val Ala Ala Glu Glu Leu 
            500                 505                 510         

Ala Ser Gly Arg Trp Lys Gly Leu Val Ile Gly Ala Arg Thr Glu Asn 
        515                 520                 525             

Phe Cys Val Gly Ala Asn Val Ala Ile Met Leu Met Glu Ala Gln Glu 
    530                 535                 540                 

Glu Glu Trp Asp Glu Leu Glu Phe Met Ala Arg Glu Phe Gln Asn Ala 
545                 550                 555                 560 

Phe Met Ala Leu Lys Leu Ala Pro Lys Pro Val Val Val Ala Pro Tyr 
                565                 570                 575     

Gly Met Thr Leu Gly Gly Gly Tyr Glu Leu Cys Ala Val Ala Asp Arg 
            580                 585                 590         

Val Val Ala Ala Ala Glu Ser Tyr Ile Gly Leu Val Glu Val Gly Val 
        595                 600                 605             

Gly Val Ile Pro Gly Ala Gly Gly Asn Lys Glu Met Leu Ile Arg Gly 
    610                 615                 620                 

Leu Glu Gly Leu Pro Ala Gly Ala Gln Val Asp Ile Gln Pro Ile Leu 
625                 630                 635                 640 

Asn Arg Ile Phe Glu Thr Ile Ala Thr Ala Lys Val Ala Thr Ser Ala 
                645                 650                 655     

Arg Glu Ala Gln Glu Met Gly Tyr Leu Arg Lys Ser Asp Val Ile Val 
            660                 665                 670         

Val Asn Lys Asp His Gln Leu Tyr Glu Ala Lys Arg Val Val Leu Ala 
        675                 680                 685             

Leu Glu Ala Ala Gly Tyr Arg Pro Pro Glu Pro Ala Leu Ile Pro Ala 
    690                 695                 700                 

Ala Gly Pro Glu Gly Arg Ala Val Leu Glu Leu Gly Ala Tyr Gly Met 
705                 710                 715                 720 

Phe Met Gly Gly Trp Ala Thr Glu His Glu Leu Phe Ile Ala Arg Lys 
                725                 730                 735     

Leu Ala Tyr Val Leu Thr Gly Gly Asn Val Pro Ala Gly Thr Leu Val 
            740                 745                 750         

Thr Glu Gln Tyr Leu Leu Asp Leu Glu Arg Glu Ala Phe Leu Ser Leu 
        755                 760                 765             

Leu Gly Thr Lys Lys Thr Gln Glu Arg Met Ala His Leu Leu Lys Thr 
    770                 775                 780                 

Gly Lys Pro Leu Arg Asn 
785                 790 

<210>   549
<211>   791
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   549
Arg Gln Ile Arg Lys Val Ala Val Ile Gly Ser Gly Val Met Gly Ser 
                5                   10                  15      

Gly Ile Ala Ala His Leu Ala Asn Val Gly Ile Pro Ser Leu Leu Leu 
            20                  25                  30          

Asp Ile Val Pro Asn Gln Leu Thr Glu Glu Glu Gln Arg Lys Gly Leu 
        35                  40                  45              

Thr Leu Glu Asp Arg Ala Val Arg Asn Arg Leu Ala Thr Leu Ala Leu 
    50                  55                  60                  

Lys Lys Leu Gln Lys Gln Lys Pro Ala Pro Leu Ser Arg Lys Ser His 
65                  70                  75                  80  

Val His Tyr Ile Gln Pro Gly Asn Leu Glu Asp Asp Val Glu Lys Leu 
                85                  90                  95      

Ala Glu Val Asp Trp Ile Ile Glu Val Val Val Glu Asn Leu Asp Val 
            100                 105                 110         

Lys Lys Gln Leu Phe Glu Lys Val Asp Gln Tyr Arg Lys Gln Gly Thr 
        115                 120                 125             

Leu Val Ser Ser Asn Thr Ser Gly Ile Ser Ile Glu Ala Met Ala Lys 
    130                 135                 140                 

Gly Arg Ser Glu Asp Phe Gln Ala His Phe Leu Gly Thr His Phe Phe 
145                 150                 155                 160 

Asn Pro Pro Arg Tyr Leu Lys Leu Leu Glu Ile Ile Pro Thr Lys Lys 
                165                 170                 175     

Thr Lys Pro Glu Val Thr Ala Phe Met Lys Ala Phe Ala Glu Asp Val 
            180                 185                 190         

Leu Gly Lys Gly Val Val Glu Gly Lys Asp Thr Pro Asn Phe Ile Ala 
        195                 200                 205             

Asn Arg Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Gln Lys Met Leu 
    210                 215                 220                 

Glu Gly Gly Tyr Ser Val Gly Glu Val Asp Ser Val Thr Gly Pro Leu 
225                 230                 235                 240 

Ile Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Val Val Gly 
                245                 250                 255     

Leu Asp Thr Phe Leu His Val Ala Lys Asn Val His Asp Val Val Asp 
            260                 265                 270         

Gly Glu Glu Lys Asp Val Phe Asp Pro Pro Val Phe Met Lys Lys Met 
        275                 280                 285             

Ala Glu Asn Gly Trp Ile Gly Ser Lys Ser Gly Gln Gly Phe Phe Leu 
    290                 295                 300                 

Lys Gln Lys Gly Glu Asn Gly Ser Glu Ile Leu Glu Leu Asn Pro Ser 
305                 310                 315                 320 

Thr Leu Glu Tyr Glu Lys Arg Lys Lys Met Lys Ala Pro Ser Ile Glu 
                325                 330                 335     

Gln Ala Lys Gln Ala Lys Ser Leu Asn Glu Lys Leu Ser Ile Leu Ile 
            340                 345                 350         

Gln Ala Asn Asp Arg Ala Gly Gln Leu Leu Trp Asn Leu Met Lys Pro 
        355                 360                 365             

Val Leu Ile Tyr Ser Ala Glu Lys Val Tyr Glu Ile Ala Gly Asp Ile 
    370                 375                 380                 

Lys Ala Val Asp Asp Ala Met Lys Trp Gly Phe Gly Trp Glu Gln Gly 
385                 390                 395                 400 

Pro Phe Glu Met Trp Asp Ala Ile Gly Val Ala Ser Ser Val Gln Arg 
                405                 410                 415     

Met Glu Glu Glu Gly Ala Thr Val Pro Ser Trp Val Lys Glu Met Leu 
            420                 425                 430         

Thr Ser Gly Arg Glu Arg Phe Tyr Gln Asp Gly Thr Phe Tyr His His 
        435                 440                 445             

Gly Glu Ala Lys Val Ile Pro Ile Asn Gly Lys Ile Ile His Leu Lys 
    450                 455                 460                 

Ala Leu Lys Pro Glu Arg Val Ile Thr Lys Asn Ser Gly Ala Ser Leu 
465                 470                 475                 480 

Ile Asp Leu Gly Asp Asp Val Ala Leu Leu Glu Phe His Ser Pro Asn 
                485                 490                 495     

Asn Ser Ile Gly Phe Asp Val Val Gln Met Ile Asn Lys Ala Val Asp 
            500                 505                 510         

Glu Val Glu Ala Asn Tyr Lys Gly Leu Val Ile Gly Asn Gln Gly Lys 
        515                 520                 525             

Asn Phe Cys Val Gly Ala Asn Leu Met Met Ile Leu Met Glu Ala Gln 
    530                 535                 540                 

Asp Asp Asn Phe Phe Glu Ile Asp Met Val Val Arg Gln Phe Gln Gln 
545                 550                 555                 560 

Ala Met Ala Lys Ile Arg Tyr Ser Gln Lys Pro Val Val Ser Ala Pro 
                565                 570                 575     

Phe Ala Met Thr Leu Gly Gly Gly Thr Glu Ile Cys Leu Pro Thr Ala 
            580                 585                 590         

Ser Ile Gln Ala Ser Leu Glu Thr Tyr Met Gly Leu Val Glu Val Gly 
        595                 600                 605             

Val Gly Val Ile Pro Gly Gly Gly Gly Asn Lys Glu Leu Tyr Leu Arg 
    610                 615                 620                 

His Leu Glu Arg Leu Pro Glu Gly Ala Asn Ile Asp Leu Gln Ser Ile 
625                 630                 635                 640 

Ala Asn Lys Thr Phe Glu Thr Ile Ala Met Ala Lys Val Ser Thr Ser 
                645                 650                 655     

Ala His Glu Ala Met Glu Asn Gly Phe Leu Ser Glu Arg Asp Gly Val 
            660                 665                 670         

Val Val Asn Gly Asp His Leu Leu Tyr Gln Ala Lys Gln Gln Val Ile 
        675                 680                 685             

His Leu His Asp Ala Gly Tyr Arg Pro Pro Ala Arg Lys Lys Ile Pro 
    690                 695                 700                 

Val Val Gly Glu Thr Gly Tyr Ala Thr Met Leu Leu Gly Ala Lys Ser 
705                 710                 715                 720 

Met Lys Phe Gly Gly Met Ile Ser Glu His Asp Leu Lys Ile Ala Glu 
                725                 730                 735     

Lys Leu Ala Phe Val Ile Ala Gly Gly Arg Val Ala Lys Gly Thr Leu 
            740                 745                 750         

Val Asp Glu Gln Tyr Leu Leu Asp Leu Glu Arg Glu Ala Phe Leu Ser 
        755                 760                 765             

Leu Val Gly Glu Pro Lys Ser Gln Gln Arg Met Gln His Met Leu Met 
    770                 775                 780                 

Lys Gly Lys Pro Leu Arg Asn 
785                 790     

<210>   550
<211>   790
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   550
Ile Gln Lys Ala Ala Val Ile Gly Ser Gly Val Met Gly Ser Gly Ile 
                5                   10                  15      

Ala Ala His Leu Ala Asn Ile Gly Ile Pro Val Leu Leu Leu Asp Ile 
            20                  25                  30          

Val Pro Asn Ala Leu Thr Glu Ala Glu Lys Ala Lys Gly Tyr Thr Leu 
        35                  40                  45              

Glu Asp Lys Ala Val Arg Asn Arg Phe Ser Gln Ser Ala Leu Gln Lys 
    50                  55                  60                  

Leu Leu Lys Gln Lys Pro Ala Pro Leu Thr Ser Lys Lys Ser Leu Ala 
65                  70                  75                  80  

Leu Ile Glu Ala Gly Asn Leu Glu Asp Asp Leu Glu Arg Leu Lys Glu 
                85                  90                  95      

Ala Asp Trp Ile Ile Glu Val Val Thr Glu Arg Leu Asp Ile Lys Lys 
            100                 105                 110         

Ser Val Phe Glu Lys Val Glu Arg Phe Arg Arg Pro Gly Thr Ile Val 
        115                 120                 125             

Ser Ser Asn Thr Ser Gly Ile Ser Ile Glu Ala Met Ala Glu Gly Arg 
    130                 135                 140                 

Ser Glu Asp Phe Arg Lys His Phe Leu Gly Thr His Phe Phe Asn Pro 
145                 150                 155                 160 

Pro Arg Tyr Leu Lys Leu Leu Glu Val Ile Pro Thr Ala Asp Thr Asp 
                165                 170                 175     

Pro Asp Val Thr Ser Phe Met Lys Gln Phe Gly Glu Asp Val Leu Gly 
            180                 185                 190         

Lys Gly Val Val Leu Ala Lys Asp Thr Pro Asn Phe Ile Gly Asn Arg 
        195                 200                 205             

Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Arg Glu Met Met Lys Gly 
    210                 215                 220                 

Gly Tyr Thr Val Gly Glu Val Asp Ser Val Thr Gly Pro Val Ile Gly 
225                 230                 235                 240 

Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Val Val Gly Ile Asp 
                245                 250                 255     

Thr Phe Val His Val Ala Asn Asn Val Tyr Glu Lys Thr Glu Gly Glu 
            260                 265                 270         

Glu Lys Glu Val Phe Lys Val Pro Ala Phe Met His Lys Leu Val Glu 
        275                 280                 285             

Asn Gly Trp Leu Gly Ser Lys Thr Gly Lys Gly Phe Tyr Glu Lys Lys 
    290                 295                 300                 

Gly Lys Glu Ile Tyr Glu Leu Asn Pro Glu Thr Leu Glu Tyr Gly Glu 
305                 310                 315                 320 

Arg Thr Lys Met Lys Ala Ala Ser Leu Glu Ala Ala Arg Gln Ala Lys 
                325                 330                 335     

Gly Thr Ala Asn Lys Ile Lys Thr Ile Val Tyr Ala Asp Asp Arg Ala 
            340                 345                 350         

Gly Arg Leu Leu Trp Asn Ile Leu Ala Pro Cys Leu Val Tyr Ser Ala 
        355                 360                 365             

Glu Leu Ser Gly Val Ile Ala Asp Asp Ile Leu Ala Ile Asp Gln Ala 
    370                 375                 380                 

Met Lys Trp Gly Phe Gly Trp Lys Phe Gly Pro Phe Glu Thr Trp Asp 
385                 390                 395                 400 

Ala Ile Gly Val Glu Lys Ser Val Gln Lys Met Glu Glu Asp Gly Leu 
                405                 410                 415     

Gln Val Pro Gly Trp Val Lys Gly Met Leu Glu Lys Gly Phe Thr Ser 
            420                 425                 430         

Phe Tyr Lys Glu Glu Asn Gly Val Val Ser Tyr Tyr Asp Asn Gly Ala 
        435                 440                 445             

Tyr Lys Pro Leu Pro Ala Asn Pro Lys Glu Ile Asn Leu Lys Ala Leu 
    450                 455                 460                 

Lys Thr Gln Gly Lys Val Leu Lys Glu Asn Ala Gly Ala Ser Leu Ile 
465                 470                 475                 480 

Asp Ile Gly Asp Gly Val Leu Leu Leu Glu Phe His Ser Lys Ser Asn 
                485                 490                 495     

Thr Ile Gly Leu Asp Ile Leu Gln Met Ile Asn Tyr Ala Val Asp Glu 
            500                 505                 510         

Ala Glu Lys His Tyr Lys Gly Ile Val Ile Gly Asn Gln Gly Lys Asn 
        515                 520                 525             

Phe Cys Val Gly Ala Asn Leu Ala Leu Met Leu Met Glu Ala Gln Asp 
    530                 535                 540                 

Asp Asn Ile Phe Glu Leu Asp Met Val Val Arg Gln Phe Gln Asn Thr 
545                 550                 555                 560 

Met Met Lys Ile Lys Tyr Ser Gln Lys Pro Val Val Ala Ala Pro Phe 
                565                 570                 575     

Ala Met Thr Leu Gly Gly Gly Ala Glu Val Cys Leu His Thr Ala His 
            580                 585                 590         

Ile Gln Ala Ala Ser Glu Thr Tyr Met Gly Leu Val Glu Thr Gly Val 
        595                 600                 605             

Gly Leu Leu Pro Gly Gly Gly Gly Asn Lys Glu Leu Tyr Ile Lys His 
    610                 615                 620                 

Leu Lys Asn Ile Pro Glu Gly Val Gln Phe Asp Leu Gln Asn Val Val 
625                 630                 635                 640 

Asn Lys Val Phe Glu Thr Ile Ala Met Ala Lys Val Ser Thr Ser Ala 
                645                 650                 655     

Glu Glu Ala Arg Glu Ser Gly Phe Leu Asp Arg Thr Asp Gly Val Ser 
            660                 665                 670         

Phe Asn Gln Asp His Leu Ile Tyr Asp Ala Lys Gln Ala Val Leu Arg 
        675                 680                 685             

Leu Ala Asp Ala Gly Tyr Lys Pro Pro Val Arg Glu Lys Val Pro Val 
    690                 695                 700                 

Thr Gly Glu Ser Gly Tyr Ala Ala Leu Leu Leu Gly Ala Gln Gln Met 
705                 710                 715                 720 

His Leu Ser Gly Tyr Ile Ser Asp Tyr Asp Leu Glu Ile Ala Lys Lys 
                725                 730                 735     

Ile Ala Phe Val Leu Ser Gly Gly Lys Val Pro Phe Gly Thr Lys Val 
            740                 745                 750         

Asp Glu Gln Tyr Leu Leu Asp Leu Glu Arg Glu Ala Phe Leu Ser Leu 
        755                 760                 765             

Ile Ala Gln Pro Lys Thr Gln Gln Arg Met Gln His Met Leu Leu Lys 
    770                 775                 780                 

Gly Lys Pro Leu Arg Asn 
785                 790 

<210>   551
<211>   793
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   551
Ile Gln Gln Ile Lys Lys Ala Ala Val Leu Gly Ser Gly Val Met Gly 
                5                   10                  15      

Ser Gly Ile Ala Ala His Leu Ala Asn Ile Gly Ile Pro Thr Leu Leu 
            20                  25                  30          

Leu Asp Ile Val Pro Arg Glu Leu Asn Glu Ala Glu Gln Lys Lys Gly 
        35                  40                  45              

Leu Thr Leu Glu Asp Lys Ala Val Arg Asn Arg Ile Ser Gln Gly Ala 
    50                  55                  60                  

Leu Gln Lys Leu Leu Lys Gln Lys Pro Ala Pro Leu Thr Ser Lys Lys 
65                  70                  75                  80  

Ser Leu Ala Leu Leu Glu Ala Gly Asn Phe Glu Asp Asp Met Glu Ser 
                85                  90                  95      

Leu Lys Asp Val Asp Trp Ile Ile Glu Val Val Val Glu Asn Leu Asp 
            100                 105                 110         

Ile Lys Lys Gln Val Phe Ala Lys Val Asp Gln Phe Arg Lys Pro Gly 
        115                 120                 125             

Ser Ile Val Ser Ser Asn Thr Ser Gly Ile Ser Val Asn Ser Met Ala 
    130                 135                 140                 

Glu Gly Arg Ser Asp Asp Phe Gln Lys His Phe Ile Gly Thr His Phe 
145                 150                 155                 160 

Phe Asn Pro Pro Arg Tyr Leu Lys Leu Leu Glu Val Ile Pro Ala Lys 
                165                 170                 175     

Thr Thr Ala Pro Glu Val Leu Ser Phe Met Lys Lys Phe Gly Glu Asp 
            180                 185                 190         

Val Leu Gly Lys Gly Val Val Glu Ala Lys Asp Thr Pro Asn Phe Ile 
        195                 200                 205             

Gly Asn Arg Ile Gly Thr Tyr Gly Leu Leu Ile Thr Val Gln Glu Met 
    210                 215                 220                 

Leu Lys Gly Gly Tyr Ser Val Gly Glu Val Asp Ser Val Thr Gly Pro 
225                 230                 235                 240 

Leu Ile Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Val Val 
                245                 250                 255     

Gly Leu Asp Thr Phe Ile His Val Ala Asn Asn Val Tyr Glu Gln Val 
            260                 265                 270         

Asp Gly Lys Glu Lys Glu Ala Phe Glu Val Pro Ala Phe Met Lys Gln 
        275                 280                 285             

Met Leu Glu Asn Gly Trp Leu Gly Ser Lys Ser Gly Gln Gly Phe Phe 
    290                 295                 300                 

Lys Lys Glu Gly Lys Glu Ile Leu Glu Leu Asn Pro Asp Thr Leu Glu 
305                 310                 315                 320 

Tyr Gly Pro Arg Gln Lys Leu Lys Ala Ala Ser Val Glu Met Ser Lys 
                325                 330                 335     

Gln Glu Lys Gly Leu Ala Asn Lys Leu Lys Ala Leu Val Tyr Ala Asp 
            340                 345                 350         

Asp Lys Ala Gly Gln Leu Leu Trp Asn Ile Leu Ser Pro Ala Leu Leu 
        355                 360                 365             

Tyr Ser Ala Glu Leu Leu Gly Glu Ile Ala Asp Asp Val Ile Ser Ile 
    370                 375                 380                 

Asp Lys Ala Met Lys Trp Gly Phe Gly Trp Gln Met Gly Pro Phe Glu 
385                 390                 395                 400 

Thr Trp Asp Ser Ile Gly Leu Glu Lys Ser Val Gly Lys Met Glu Ala 
                405                 410                 415     

Glu Gly Lys Glu Val Pro Ala Trp Ile Lys Glu Met Leu Ser Asn Gly 
            420                 425                 430         

His Thr Ser Phe Tyr Lys Glu Glu Asn Gly Asp Ile Ser Phe Tyr Lys 
        435                 440                 445             

Asn Gly Glu Tyr Val Pro Glu Glu Glu Asn Pro Lys Asn Ile Asn Leu 
    450                 455                 460                 

Lys Lys Leu Lys Lys Gln Lys Gly Val Ile Lys Lys Asn Thr Gly Ala 
465                 470                 475                 480 

Ser Leu Leu Asp Leu Gly Asp Gly Val Ala Leu Leu Glu Phe His Ser 
                485                 490                 495     

Gln Ser Asn Ala Ile Gly Leu Asp Ile Ile Gln Met Ile Asn Phe Ala 
            500                 505                 510         

Val Asp Glu Val Glu Lys Asn Tyr Lys Gly Leu Val Ile Gly Asn Gln 
        515                 520                 525             

Gly Lys Asn Phe Ser Val Gly Ala Asn Leu Ala Met Ile Leu Met Glu 
    530                 535                 540                 

Ala Gln Asp Asp Asn Val Phe Glu Leu Asp Met Val Val Arg His Phe 
545                 550                 555                 560 

Gln Gln Ala Met Met Lys Ile Lys Tyr Ser Thr Lys Pro Val Val Ala 
                565                 570                 575     

Ala Pro Phe Ala Met Thr Leu Gly Gly Gly Ala Glu Ile Cys Leu Pro 
            580                 585                 590         

Ala Ala His Ile Gln Ala Ser Met Glu Thr Tyr Met Gly Leu Val Glu 
        595                 600                 605             

Ala Gly Val Gly Leu Ile Pro Gly Gly Gly Gly Asn Lys Glu Leu Tyr 
    610                 615                 620                 

Ile Lys His Leu Glu Gly Met Pro Asn Gly Val Glu Phe Asp Leu Gln 
625                 630                 635                 640 

Lys Val Ala Asn Lys Val Phe Glu Ser Ile Ala Met Ala Lys Val Ser 
                645                 650                 655     

Thr Ser Gly Glu Glu Ala Arg Glu Asn Asn Phe Leu Gly Ala Ala Asp 
            660                 665                 670         

Gly Ile Ser Val Asn Gly Asp His Gln Leu Tyr Asp Ala Lys Gln Ala 
        675                 680                 685             

Val Leu Ala Leu His Glu Gln Gly Tyr Thr Pro Pro Val Arg Lys Lys 
    690                 695                 700                 

Ile Pro Val Val Gly Glu Thr Gly Tyr Ala Thr Leu Leu Leu Gly Ala 
705                 710                 715                 720 

Gln Ala Met Leu Tyr Ser Gly Phe Ile Ser Glu His Asp Leu Lys Ile 
                725                 730                 735     

Ala Gln Lys Leu Ala Tyr Val Ile Ala Gly Gly Lys Val Pro Tyr Gly 
            740                 745                 750         

Thr Glu Val Asp Glu Gln Tyr Leu Leu Asp Leu Glu Arg Glu Ala Phe 
        755                 760                 765             

Leu Ser Leu Val Ala Gln Pro Lys Ser Gln Gln Arg Met Gln His Met 
    770                 775                 780                 

Leu Val Lys Gly Lys Pro Leu Arg Asn 
785                 790             

<210>   552
<211>   797
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   552
Met Arg Gln Ile Arg Arg Ala Ala Val Ile Gly Ser Gly Val Met Gly 
                5                   10                  15      

Ala Gln Ile Ala Ala His Leu Ala Asn Val Gly Ile Pro Ser Leu Leu 
            20                  25                  30          

Leu Asp Leu Val Pro Gln Glu Leu Thr Ala Glu Glu Gln Lys Lys Gly 
        35                  40                  45              

Leu Ser Leu Asp His Pro Ala Val Arg Asn Arg Leu Ala Thr Glu Ala 
    50                  55                  60                  

Ile Arg Arg Leu Asn Lys Leu Ser Pro Ala Pro Leu Phe Arg Ala Asp 
65                  70                  75                  80  

Tyr Ala Lys Leu Ile Thr Pro Gly Asn Leu Glu Asp Asp Leu His Arg 
                85                  90                  95      

Ile Cys Glu Val Asp Trp Val Ile Glu Val Ile Val Glu Ser Leu Glu 
            100                 105                 110         

Pro Lys Arg Gln Leu Leu Glu Arg Ile Glu Arg Tyr Trp His Glu Gly 
        115                 120                 125             

Met Ile Val Ser Thr Asn Thr Ser Gly Ile Ser Ile Asn Ala Met Val 
    130                 135                 140                 

Glu Gly Arg Ser Glu Ala Phe Arg Arg His Phe Leu Gly Thr His Phe 
145                 150                 155                 160 

Phe Asn Pro Pro Arg Tyr Met Lys Leu Leu Glu Val Ile Pro Gly Arg 
                165                 170                 175     

Asp Thr Asp Pro Ala Ile Val Glu Phe Met Arg Asp Phe Gly Thr Glu 
            180                 185                 190         

Arg Leu Gly Lys Gly Val Val Leu Ala Lys Asp Thr Pro Asn Phe Ile 
        195                 200                 205             

Ala Asn Arg Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Glu Glu Met 
    210                 215                 220                 

Gln Lys Gly Gly Phe Thr Val Glu Glu Val Asp Ala Ile Thr Gly Pro 
225                 230                 235                 240 

Ala Leu Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Leu Val 
                245                 250                 255     

Gly Ile Asp Thr Phe Val His Val Ala Asn Asn Val Arg Gln Asn Val 
            260                 265                 270         

Thr Asp Pro Gln Glu Gln Arg Ala Phe Glu Val Pro Glu Ala Ile Gln 
        275                 280                 285             

Lys Leu Val Glu Arg Gly Trp Leu Gly Glu Lys Ser Gly Gln Gly Phe 
    290                 295                 300                 

Tyr Lys Arg Val Lys Gln Asn Gly Gln Arg Gln Ile Leu Val Leu Asp 
305                 310                 315                 320 

Leu Asp Thr Phe Glu Tyr Arg Glu Gln Lys Lys Ile Ala Ser Ser Ala 
                325                 330                 335     

Leu Glu Ala Ser Lys Gln Ala Lys Gly Ala Ala Gly Lys Ala Lys Ala 
            340                 345                 350         

Leu Leu Gln Gly Gly Asp Arg Tyr Ala Glu Leu Ala Trp Asn Ile Val 
        355                 360                 365             

Lys Arg Val Leu Val Tyr Ser Ala Glu Lys Leu Gly Glu Ile Ala Asp 
    370                 375                 380                 

Thr Ile Gln Asp Ile Asp Ala Ala Met Arg Trp Gly Phe Asn Trp Glu 
385                 390                 395                 400 

Leu Gly Pro Phe Glu Leu Trp Asp Ala Leu Gly Leu Val Glu Thr Ala 
                405                 410                 415     

Glu Arg Met Arg Ala Glu Gly Leu Arg Leu Pro Ser Trp Val Glu Asp 
            420                 425                 430         

Trp Ile Ala Ala Gly His Arg Ala Phe Tyr Glu Glu Lys Asp Gly Lys 
        435                 440                 445             

Leu Thr Met Pro Val Asn Gly Lys Pro Glu Pro Val Arg Val Pro Ala 
    450                 455                 460                 

Gly Val Ile Asp Leu Ala Ala Leu Lys Lys Ala Gly Lys Val Ile Ala 
465                 470                 475                 480 

Gln Asn Thr Gly Ala Ser Leu Ile Asp Leu Gly Asp Gly Val Ala Cys 
                485                 490                 495     

Leu Glu Phe His Ser Gln Asn Asn Ala Ile Gly Pro Asp Ile Leu Thr 
            500                 505                 510         

Met Ile Glu Lys Ser Val Ala Ile Ala Glu Arg Asp Phe Ala Gly Leu 
        515                 520                 525             

Val Ile Ala Asn Gln Gly Lys Asn Phe Cys Val Gly Ala Asn Leu Met 
    530                 535                 540                 

Leu Ile Leu Met Ala Ala Gln Glu Gly Asp Trp Asp Glu Ile Asp Leu 
545                 550                 555                 560 

Ser Ile Arg Gln Phe His Arg Ala Met Leu Ala Leu Arg Tyr Ser Gln 
                565                 570                 575     

Val Pro Val Val Ala Ala Pro His Arg Met Thr Leu Gly Gly Gly Val 
            580                 585                 590         

Glu Val Cys Leu Ala Ser Ser Arg Val Leu Pro Ala Ala Glu Thr Tyr 
        595                 600                 605             

Phe Gly Leu Val Glu Val Gly Val Gly Val Ile Pro Gly Gly Gly Gly 
    610                 615                 620                 

Cys Lys Glu Thr Ala Arg Arg Val Ala Glu Ser Val Gly Pro Glu Asp 
625                 630                 635                 640 

Asp Leu Val Pro Ala Leu Ala Arg Met Phe Gln Ala Ile Gly Thr Ala 
                645                 650                 655     

Lys Val Ser Thr Ser Gly Ala Glu Ala Leu Ala Met Gly Trp Leu Arg 
            660                 665                 670         

Glu Thr Asp Arg Val Val Val Asn Asp Asp Leu Arg Ile Ser Ala Ala 
        675                 680                 685             

Lys Ala Glu Val Leu Arg Met Ala Glu Ile Gly Tyr Thr Ala Pro Pro 
    690                 695                 700                 

Lys Ala Lys Glu Ile Arg Val Ala Gly Arg Asp Gly Lys Ala Thr Leu 
705                 710                 715                 720 

Gln Met Ala Ala Arg Ser Met Trp Asn Gly Gly Tyr Ile Thr Asp Tyr 
                725                 730                 735     

Asp Leu His Ile Ala Tyr Lys Leu Ala His Val Leu Ala Gly Gly Asp 
            740                 745                 750         

Val Pro Ala Gly Ser Leu Val Ser Glu Asp Tyr Leu Leu Asp Leu Glu 
        755                 760                 765             

Arg Glu Ala Phe Leu Ser Leu Cys Gly Glu Pro Lys Thr Ile Gln Arg 
    770                 775                 780                 

Met Gln His Met Leu Ala Thr Gly Lys Pro Leu Arg Asn 
785                 790                 795         

<210>   553
<211>   797
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   553
Met Arg Gln Ile Arg Arg Ala Ala Val Ile Gly Ser Gly Val Met Gly 
                5                   10                  15      

Ala Gln Ile Ala Ala His Leu Ala Asn Val Gly Ile Pro Ser Leu Leu 
            20                  25                  30          

Leu Asp Leu Val Pro Gln Glu Leu Thr Ala Glu Glu Gln Lys Lys Gly 
        35                  40                  45              

Leu Ser Leu Asp His Pro Ala Val Arg Asn Arg Leu Ala Thr Glu Ala 
    50                  55                  60                  

Ile Arg Arg Leu Gln Lys Leu Ser Pro Ala Pro Leu Phe Arg Ala Asp 
65                  70                  75                  80  

Tyr Ala Lys Leu Ile Thr Pro Gly Asn Leu Glu Asp Asp Leu His Arg 
                85                  90                  95      

Ile Cys Glu Val Asp Trp Val Ile Glu Val Ile Val Glu Ser Leu Glu 
            100                 105                 110         

Pro Lys Arg Gln Leu Leu Glu Arg Ile Glu Arg Tyr Trp His Glu Gly 
        115                 120                 125             

Met Ile Val Ser Thr Asn Thr Ser Gly Ile Ser Ile Asn Ala Met Val 
    130                 135                 140                 

Glu Gly Arg Ser Glu Ala Phe Arg Arg His Phe Leu Gly Thr His Phe 
145                 150                 155                 160 

Phe Asn Pro Pro Arg Tyr Met Lys Leu Leu Glu Val Ile Pro Gly Arg 
                165                 170                 175     

Asp Thr Asp Pro Ala Ile Val Glu Phe Met Arg Asp Phe Gly Thr Glu 
            180                 185                 190         

Arg Leu Gly Lys Gly Val Val Leu Ala Lys Asp Thr Pro Asn Phe Ile 
        195                 200                 205             

Ala Asn Arg Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Glu Glu Met 
    210                 215                 220                 

Gln Lys Gly Gly Phe Thr Val Glu Glu Val Asp Ala Ile Thr Gly Pro 
225                 230                 235                 240 

Ala Leu Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Leu Val 
                245                 250                 255     

Gly Ile Asp Thr Phe Val His Val Ala Asn Asn Val Arg Gln Asn Val 
            260                 265                 270         

Thr Asp Pro Gln Glu Gln Arg Ala Phe Glu Val Pro Glu Ala Ile Gln 
        275                 280                 285             

Lys Leu Val Glu Arg Gly Trp Leu Gly Glu Lys Ser Gly Gln Gly Phe 
    290                 295                 300                 

Tyr Lys Arg Val Lys Gln Asn Gly Gln Arg Gln Ile Leu Val Leu Asp 
305                 310                 315                 320 

Leu Asp Thr Phe Glu Tyr Arg Glu Gln Lys Lys Ile Ala Ser Ser Ala 
                325                 330                 335     

Leu Glu Ala Ser Lys Gln Ala Lys Gly Ala Ala Gly Lys Ala Lys Ala 
            340                 345                 350         

Leu Leu Gln Gly Gly Asp Arg Tyr Ala Glu Leu Ala Trp Asn Ile Val 
        355                 360                 365             

Lys Arg Val Leu Val Tyr Ser Ala Glu Lys Leu Gly Glu Ile Ala Asp 
    370                 375                 380                 

Thr Ile Gln Asp Ile Asp Ala Ala Met Arg Trp Gly Phe Asn Trp Glu 
385                 390                 395                 400 

Leu Gly Pro Phe Glu Leu Trp Asp Ala Leu Gly Leu Val Glu Thr Ala 
                405                 410                 415     

Glu Arg Met Arg Ala Glu Gly Leu Arg Leu Pro Ser Trp Val Glu Asp 
            420                 425                 430         

Trp Ile Ala Ala Gly His Arg Ala Phe Tyr Glu Glu Lys Asp Gly Lys 
        435                 440                 445             

Leu Thr Met Pro Val Asn Gly Lys Pro Glu Pro Val Arg Val Pro Ala 
    450                 455                 460                 

Gly Val Ile Asp Leu Ala Ala Leu Lys Lys Ala Gly Lys Val Ile Ala 
465                 470                 475                 480 

Gln Asn Thr Gly Ala Ser Leu Ile Asp Leu Gly Asp Gly Val Ala Cys 
                485                 490                 495     

Leu Glu Phe His Ser Gln Asn Asn Ala Ile Gly Pro Asp Ile Leu Thr 
            500                 505                 510         

Met Ile Glu Lys Ser Val Ala Ile Ala Glu Lys Asp Phe Ala Gly Leu 
        515                 520                 525             

Val Ile Ala Asn Gln Gly Lys Asn Phe Cys Val Gly Ala Asn Leu Met 
    530                 535                 540                 

Leu Ile Leu Met Ala Ala Gln Glu Gly Asp Trp Asp Glu Ile Asp Leu 
545                 550                 555                 560 

Ser Ile Arg Gln Phe His Arg Ala Met Leu Ala Leu Arg Tyr Ser Gln 
                565                 570                 575     

Val Pro Val Val Ala Ala Pro His Arg Met Thr Leu Gly Gly Gly Val 
            580                 585                 590         

Glu Val Cys Leu Ala Ser Ser Arg Val Leu Pro Ala Ala Glu Thr Tyr 
        595                 600                 605             

Phe Gly Leu Val Glu Val Gly Val Gly Val Ile Pro Gly Gly Gly Gly 
    610                 615                 620                 

Cys Lys Glu Thr Ala Arg Arg Val Ala Glu Ser Val Gly Pro Glu Asp 
625                 630                 635                 640 

Asp Leu Val Pro Ala Leu Ala Arg Met Phe Gln Ala Ile Gly Thr Ala 
                645                 650                 655     

Lys Val Ser Thr Ser Gly Ala Glu Ala Leu Ala Met Gly Trp Leu Arg 
            660                 665                 670         

Glu Thr Asp Arg Val Val Val Asn Asp Asp Leu Arg Ile Ser Ala Ala 
        675                 680                 685             

Lys Ala Glu Val Leu Arg Met Ala Glu Ile Gly Tyr Thr Ala Pro Pro 
    690                 695                 700                 

Lys Ala Lys Glu Ile Arg Val Ala Gly Arg Asp Gly Lys Ala Thr Leu 
705                 710                 715                 720 

Gln Met Ala Ala Arg Ser Met Trp Asn Gly Gly Tyr Ile Thr Asp Tyr 
                725                 730                 735     

Asp Leu His Ile Ala Tyr Lys Leu Ala His Val Leu Ala Gly Gly Asp 
            740                 745                 750         

Val Pro Ala Gly Ser Leu Val Ser Glu Asp Tyr Leu Leu Asp Leu Glu 
        755                 760                 765             

Arg Glu Ala Phe Leu Ser Leu Cys Gly Glu Pro Lys Thr Ile Gln Arg 
    770                 775                 780                 

Met Gln His Met Leu Ala Thr Gly Lys Pro Leu Arg Asn 
785                 790                 795         

<210>   554
<211>   797
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   554
Met Arg Gln Ile Arg Arg Ala Ala Val Ile Gly Ser Gly Val Met Gly 
                5                   10                  15      

Ala Gln Ile Ala Ala His Leu Ala Asn Val Gly Ile Pro Ser Leu Leu 
            20                  25                  30          

Leu Asp Leu Val Pro Gln Glu Leu Thr Ala Glu Glu Gln Lys Lys Gly 
        35                  40                  45              

Leu Ser Leu Asp His Pro Ala Val Arg Asn Arg Leu Ala Thr Glu Ala 
    50                  55                  60                  

Ile Arg Arg Leu Asn Lys Leu Ser Pro Ala Pro Leu Phe Arg Ala Asp 
65                  70                  75                  80  

Tyr Ala Lys Leu Ile Thr Pro Gly Asn Leu Glu Asp Asp Leu His Arg 
                85                  90                  95      

Ile Cys Glu Val Asp Trp Val Ile Glu Val Ile Val Glu Ser Leu Glu 
            100                 105                 110         

Pro Lys Arg Gln Leu Leu Glu Arg Ile Glu Arg Tyr Trp His Glu Gly 
        115                 120                 125             

Met Ile Val Ser Thr Asn Thr Ser Gly Ile Ser Ile Asn Ala Met Val 
    130                 135                 140                 

Glu Gly Arg Ser Glu Ala Phe Arg Arg His Phe Leu Gly Thr His Phe 
145                 150                 155                 160 

Phe Asn Pro Pro Arg Tyr Met Lys Leu Leu Glu Val Ile Pro Gly Arg 
                165                 170                 175     

Asp Thr Asp Pro Ala Ile Val Glu Phe Met Arg Asp Phe Gly Thr Glu 
            180                 185                 190         

Arg Leu Gly Lys Gly Val Val Leu Ala Lys Asp Thr Pro Asn Phe Ile 
        195                 200                 205             

Ala Asn Arg Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Glu Glu Met 
    210                 215                 220                 

Gln Lys Gly Gly Phe Thr Val Glu Glu Val Asp Ala Ile Thr Gly Pro 
225                 230                 235                 240 

Ala Leu Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Leu Val 
                245                 250                 255     

Gly Ile Asp Thr Phe Val His Val Ala Asn Asn Val Arg Gln Asn Val 
            260                 265                 270         

Thr Asp Pro Gln Glu Gln Arg Ala Phe Glu Val Pro Glu Ala Ile Gln 
        275                 280                 285             

Lys Leu Val Glu Arg Gly Trp Leu Gly Glu Lys Ser Gly Gln Gly Phe 
    290                 295                 300                 

Tyr Lys Arg Val Lys Gln Asn Gly Gln Arg Gln Ile Leu Val Leu Asp 
305                 310                 315                 320 

Leu Asp Thr Phe Glu Tyr Arg Glu Gln Lys Lys Ile Ala Ser Ser Ala 
                325                 330                 335     

Leu Glu Ala Ser Lys Gln Ala Lys Gly Ala Ala Gly Lys Ala Lys Ala 
            340                 345                 350         

Leu Leu Gln Gly Gly Asp Arg Tyr Ala Glu Leu Ala Trp Asn Ile Val 
        355                 360                 365             

Lys Arg Val Leu Val Tyr Ser Ala Glu Lys Leu Gly Glu Ile Ala Asp 
    370                 375                 380                 

Thr Ile Gln Asp Ile Asp Ala Ala Met Arg Trp Gly Phe Asn Trp Glu 
385                 390                 395                 400 

Leu Gly Pro Phe Glu Leu Trp Asp Ala Leu Gly Leu Val Glu Thr Ala 
                405                 410                 415     

Glu Arg Met Arg Ala Glu Gly Leu Arg Leu Pro Ser Trp Val Glu Asp 
            420                 425                 430         

Trp Ile Ala Ala Gly His Arg Ala Phe Tyr Glu Glu Lys Asp Gly Lys 
        435                 440                 445             

Leu Thr Met Pro Val Asn Gly Lys Pro Glu Pro Val Arg Val Pro Ala 
    450                 455                 460                 

Gly Val Ile Asp Leu Ala Ala Leu Lys Lys Ala Gly Lys Val Ile Ala 
465                 470                 475                 480 

Gln Asn Thr Gly Ala Ser Leu Ile Asp Leu Gly Asp Gly Val Ala Cys 
                485                 490                 495     

Leu Glu Phe His Ser Gln Asn Asn Ala Ile Gly Pro Asp Ile Leu Thr 
            500                 505                 510         

Met Ile Glu Lys Ser Val Ala Ile Ala Glu Lys Asp Phe Ala Gly Leu 
        515                 520                 525             

Val Ile Ala Asn Gln Gly Lys Asn Phe Cys Val Gly Ala Asn Leu Met 
    530                 535                 540                 

Leu Ile Leu Met Ala Ala Gln Glu Gly Asp Trp Glu Glu Ile Asp Leu 
545                 550                 555                 560 

Ser Ile Arg Gln Phe His Arg Ala Met Leu Ala Leu Arg Tyr Ser Gln 
                565                 570                 575     

Val Pro Val Val Ala Ala Pro His Arg Met Thr Leu Gly Gly Gly Val 
            580                 585                 590         

Glu Val Cys Leu Ala Ser Ser Arg Val Leu Pro Ala Ala Glu Thr Tyr 
        595                 600                 605             

Phe Gly Leu Val Glu Val Gly Val Gly Val Ile Pro Gly Gly Gly Gly 
    610                 615                 620                 

Cys Lys Glu Thr Ala Arg Arg Val Ala Glu Ser Val Gly Pro Glu Asp 
625                 630                 635                 640 

Asp Leu Val Pro Ala Leu Ala Arg Met Phe Gln Ala Ile Gly Thr Ala 
                645                 650                 655     

Lys Val Ser Thr Ser Gly Ala Glu Ala Leu Ala Met Gly Trp Leu Arg 
            660                 665                 670         

Glu Thr Asp Arg Val Val Val Asn Asp Asp Leu Arg Ile Ser Ala Ala 
        675                 680                 685             

Lys Ala Glu Val Leu Arg Met Ala Glu Ile Gly Tyr Thr Ala Pro Pro 
    690                 695                 700                 

Lys Ala Lys Glu Ile Arg Val Ala Gly Arg Asp Gly Lys Ala Thr Leu 
705                 710                 715                 720 

Gln Met Ala Ala Arg Ser Met Trp Asn Gly Gly Tyr Ile Thr Asp Tyr 
                725                 730                 735     

Asp Leu His Ile Ala Tyr Lys Leu Ala His Val Leu Ala Gly Gly Asp 
            740                 745                 750         

Val Pro Ala Gly Ser Leu Val Ser Glu Asp Tyr Leu Leu Asp Leu Glu 
        755                 760                 765             

Arg Glu Ala Phe Leu Ser Leu Cys Gly Glu Pro Lys Thr Ile Gln Arg 
    770                 775                 780                 

Met Gln His Met Leu Ala Thr Gly Lys Pro Leu Arg Asn 
785                 790                 795         

<210>   555
<211>   797
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   555
Met Arg Gln Ile Arg Arg Ala Ala Val Ile Gly Ser Gly Val Met Gly 
                5                   10                  15      

Ala Gln Ile Ala Ala His Leu Ala Asn Val Gly Ile Pro Ser Leu Leu 
            20                  25                  30          

Leu Asp Leu Val Pro Gln Glu Leu Thr Ala Glu Glu Gln Lys Lys Gly 
        35                  40                  45              

Leu Ser Leu Asp His Pro Ala Val Arg Asn Arg Leu Ala Thr Glu Ala 
    50                  55                  60                  

Ile Arg Arg Leu Asn Lys Leu Ser Pro Ala Pro Leu Phe Arg Ala Asp 
65                  70                  75                  80  

Tyr Ala Lys Leu Ile Thr Pro Gly Asn Leu Glu Asp Asp Leu His Arg 
                85                  90                  95      

Ile Cys Glu Val Asp Trp Val Ile Glu Val Ile Val Glu Ser Leu Glu 
            100                 105                 110         

Pro Lys Arg Gln Leu Leu Glu Arg Ile Glu Arg Tyr Trp His Glu Gly 
        115                 120                 125             

Met Ile Val Ser Thr Asn Thr Ser Gly Ile Ser Ile Asn Ala Met Val 
    130                 135                 140                 

Glu Gly Arg Ser Glu Ala Phe Arg Arg His Phe Leu Gly Thr His Phe 
145                 150                 155                 160 

Phe Asn Pro Pro Arg Tyr Met Lys Leu Leu Glu Val Ile Pro Gly Arg 
                165                 170                 175     

Asp Thr Asp Pro Ala Ile Val Glu Phe Met Arg Asp Phe Gly Thr Glu 
            180                 185                 190         

Arg Leu Gly Lys Gly Val Val Leu Ala Lys Asp Thr Pro Asn Phe Ile 
        195                 200                 205             

Ala Asn Arg Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Glu Glu Met 
    210                 215                 220                 

Gln Lys Gly Gly Phe Thr Val Glu Glu Val Asp Ala Ile Thr Gly Pro 
225                 230                 235                 240 

Ala Leu Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Leu Val 
                245                 250                 255     

Gly Ile Asp Thr Phe Val His Val Ala Asn Asn Val Arg Gln Asn Val 
            260                 265                 270         

Thr Asp Pro Gln Glu Gln Arg Ala Phe Glu Val Pro Glu Ala Ile Gln 
        275                 280                 285             

Lys Leu Val Glu Arg Gly Trp Leu Gly Glu Lys Ser Gly Gln Gly Phe 
    290                 295                 300                 

Tyr Lys Arg Val Lys Gln Asn Gly Gln Arg Gln Ile Leu Val Leu Asp 
305                 310                 315                 320 

Leu Asp Thr Phe Glu Tyr Arg Glu Gln Lys Lys Ile Ala Ser Ser Ala 
                325                 330                 335     

Leu Glu Ala Ser Lys Gln Ala Lys Gly Ala Ala Gly Lys Ala Lys Ala 
            340                 345                 350         

Leu Leu Gln Gly Gly Asp Arg Tyr Ala Glu Leu Ala Trp Asn Ile Val 
        355                 360                 365             

Lys Arg Val Leu Val Tyr Ser Ala Glu Lys Leu Gly Glu Ile Ala Asp 
    370                 375                 380                 

Thr Ile Gln Asp Ile Asp Ala Ala Met Arg Trp Gly Phe Asn Trp Glu 
385                 390                 395                 400 

Leu Gly Pro Phe Glu Leu Trp Asp Ala Leu Gly Leu Val Glu Thr Ala 
                405                 410                 415     

Glu Arg Met Arg Ala Glu Gly Leu Arg Leu Pro Ser Trp Val Glu Asp 
            420                 425                 430         

Trp Ile Ala Ala Gly His Arg Ala Phe Tyr Glu Glu Lys Asp Gly Lys 
        435                 440                 445             

Leu Thr Met Pro Val Asn Gly Lys Pro Glu Pro Val Arg Val Pro Ala 
    450                 455                 460                 

Gly Val Ile Asp Leu Ala Ala Leu Lys Lys Ala Gly Lys Val Ile Ala 
465                 470                 475                 480 

Gln Asn Thr Gly Ala Ser Leu Ile Asp Leu Gly Asp Gly Val Ala Cys 
                485                 490                 495     

Leu Glu Phe His Ser Gln Asn Asn Ala Ile Gly Pro Asp Ile Leu Thr 
            500                 505                 510         

Met Ile Glu Lys Ser Val Ala Ile Ala Glu Lys Asp Phe Ala Gly Leu 
        515                 520                 525             

Val Ile Ala Asn Gln Gly Lys Asn Phe Cys Val Gly Ala Asn Leu Met 
    530                 535                 540                 

Leu Ile Leu Met Ala Ala Gln Glu Gly Asp Trp Asp Glu Ile Asp Leu 
545                 550                 555                 560 

Ser Ile Arg Gln Phe His Arg Ala Met Leu Ala Leu Arg Tyr Ser Asn 
                565                 570                 575     

Val Pro Val Val Ala Ala Pro His Arg Met Thr Leu Gly Gly Gly Val 
            580                 585                 590         

Glu Val Cys Leu Ala Ser Ser Arg Val Leu Pro Ala Ala Glu Thr Tyr 
        595                 600                 605             

Phe Gly Leu Val Glu Val Gly Val Gly Val Ile Pro Gly Gly Gly Gly 
    610                 615                 620                 

Cys Lys Glu Thr Ala Arg Arg Val Ala Glu Ser Val Gly Pro Glu Asp 
625                 630                 635                 640 

Asp Leu Val Pro Ala Leu Ala Arg Met Phe Gln Ala Ile Gly Thr Ala 
                645                 650                 655     

Lys Val Ser Thr Ser Gly Ala Glu Ala Leu Ala Met Gly Trp Leu Arg 
            660                 665                 670         

Glu Thr Asp Arg Val Val Val Asn Asp Asp Leu Arg Ile Ser Ala Ala 
        675                 680                 685             

Lys Ala Glu Val Leu Arg Met Ala Glu Ile Gly Tyr Thr Ala Pro Pro 
    690                 695                 700                 

Lys Ala Lys Glu Ile Arg Val Ala Gly Arg Asp Gly Lys Ala Thr Leu 
705                 710                 715                 720 

Gln Met Ala Ala Arg Ser Met Trp Asn Gly Gly Tyr Ile Thr Asp Tyr 
                725                 730                 735     

Asp Leu His Ile Ala Tyr Lys Leu Ala His Val Leu Ala Gly Gly Asp 
            740                 745                 750         

Val Pro Ala Gly Ser Leu Val Ser Glu Asp Tyr Leu Leu Asp Leu Glu 
        755                 760                 765             

Arg Glu Ala Phe Leu Ser Leu Cys Gly Glu Pro Lys Thr Ile Gln Arg 
    770                 775                 780                 

Met Gln His Met Leu Ala Thr Gly Lys Pro Leu Arg Asn 
785                 790                 795         

<210>   556
<211>   797
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   556
Met Arg Gln Ile Arg Arg Ala Ala Val Ile Gly Ser Gly Val Met Gly 
                5                   10                  15      

Ala Gln Ile Ala Ala His Leu Ala Asn Val Gly Ile Pro Ser Leu Leu 
            20                  25                  30          

Leu Asp Leu Val Pro Gln Glu Leu Thr Ala Glu Glu Gln Lys Lys Gly 
        35                  40                  45              

Leu Ser Leu Asp His Pro Ala Val Arg Asn Arg Leu Ala Thr Glu Ala 
    50                  55                  60                  

Ile Arg Arg Leu Asn Lys Leu Ser Pro Ala Pro Leu Phe Arg Ala Asp 
65                  70                  75                  80  

Tyr Ala Lys Leu Ile Thr Pro Gly Asn Leu Glu Asp Asp Leu His Arg 
                85                  90                  95      

Ile Cys Glu Val Asp Trp Val Ile Glu Val Ile Val Glu Ser Leu Glu 
            100                 105                 110         

Pro Lys Arg Gln Leu Leu Glu Arg Ile Glu Arg Tyr Trp His Glu Gly 
        115                 120                 125             

Met Ile Val Ser Thr Asn Thr Ser Gly Ile Ser Ile Asn Ala Met Val 
    130                 135                 140                 

Glu Gly Arg Ser Glu Ala Phe Arg Arg His Phe Leu Gly Thr His Phe 
145                 150                 155                 160 

Phe Asn Pro Pro Arg Tyr Met Lys Leu Leu Glu Val Ile Pro Gly Arg 
                165                 170                 175     

Asp Thr Asp Pro Ala Ile Val Glu Phe Met Arg Asp Phe Gly Thr Glu 
            180                 185                 190         

Arg Leu Gly Lys Gly Val Val Leu Ala Lys Asp Thr Pro Asn Phe Ile 
        195                 200                 205             

Ala Asn Arg Ile Gly Thr Tyr Gly Leu Leu Val Thr Val Glu Glu Met 
    210                 215                 220                 

Gln Lys Gly Gly Phe Thr Val Glu Glu Val Asp Ala Ile Thr Gly Pro 
225                 230                 235                 240 

Ala Leu Gly Arg Pro Lys Ser Ala Thr Phe Arg Thr Leu Asp Leu Val 
                245                 250                 255     

Gly Ile Asp Thr Phe Val His Val Ala Asn Asn Val Arg Gln Asn Val 
            260                 265                 270         

Thr Asp Pro Gln Glu Gln Arg Ala Phe Glu Val Pro Glu Ala Ile Gln 
        275                 280                 285             

Lys Leu Val Glu Arg Gly Trp Leu Gly Glu Lys Ser Gly Gln Gly Phe 
    290                 295                 300                 

Tyr Lys Arg Val Lys Gln Asn Gly Gln Arg Gln Ile Leu Val Leu Asp 
305                 310                 315                 320 

Leu Asp Thr Phe Glu Tyr Arg Glu Gln Lys Lys Ile Ala Ser Ser Ala 
                325                 330                 335     

Leu Glu Ala Ser Lys Gln Ala Lys Gly Ala Ala Gly Lys Ala Lys Ala 
            340                 345                 350         

Leu Leu Gln Gly Gly Asp Arg Tyr Ala Glu Leu Ala Trp Asn Ile Val 
        355                 360                 365             

Lys Arg Val Leu Val Tyr Ser Ala Glu Lys Leu Gly Glu Ile Ala Asp 
    370                 375                 380                 

Thr Ile Gln Asp Ile Asp Ala Ala Met Arg Trp Gly Phe Asn Trp Glu 
385                 390                 395                 400 

Leu Gly Pro Phe Glu Leu Trp Asp Ala Leu Gly Leu Val Glu Thr Ala 
                405                 410                 415     

Glu Arg Met Arg Ala Glu Gly Leu Arg Leu Pro Ser Trp Val Glu Asp 
            420                 425                 430         

Trp Ile Ala Ala Gly His Arg Ala Phe Tyr Glu Glu Lys Asp Gly Lys 
        435                 440                 445             

Leu Thr Met Pro Val Asn Gly Lys Pro Glu Pro Val Arg Val Pro Ala 
    450                 455                 460                 

Gly Val Ile Asp Leu Ala Ala Leu Lys Lys Ala Gly Lys Val Ile Ala 
465                 470                 475                 480 

Gln Asn Thr Gly Ala Ser Leu Ile Asp Leu Gly Asp Gly Val Ala Cys 
                485                 490                 495     

Leu Glu Phe His Ser Gln Asn Asn Ala Ile Gly Pro Asp Ile Leu Thr 
            500                 505                 510         

Met Ile Glu Lys Ser Val Ala Ile Ala Glu Lys Asp Phe Ala Gly Leu 
        515                 520                 525             

Val Ile Ala Asn Gln Gly Lys Asn Phe Cys Val Gly Ala Asn Leu Met 
    530                 535                 540                 

Leu Ile Leu Met Ala Ala Gln Glu Gly Asp Trp Asp Glu Ile Asp Leu 
545                 550                 555                 560 

Ser Ile Arg Gln Phe His Arg Ala Met Leu Ala Leu Arg Tyr Ser Gln 
                565                 570                 575     

Val Pro Val Val Ala Ala Pro His Arg Met Thr Leu Gly Gly Gly Val 
            580                 585                 590         

Glu Val Cys Leu Ala Ser Ser Arg Val Leu Pro Ala Ala Glu Thr Tyr 
        595                 600                 605             

Phe Gly Leu Val Glu Val Gly Val Gly Val Ile Pro Gly Gly Gly Gly 
    610                 615                 620                 

Cys Lys Glu Thr Ala Arg Arg Ile Ala Glu Ser Val Gly Pro Glu Asp 
625                 630                 635                 640 

Asp Leu Val Pro Ala Leu Ala Arg Met Phe Gln Ala Ile Gly Thr Ala 
                645                 650                 655     

Lys Val Ser Thr Ser Gly Ala Glu Ala Leu Ala Met Gly Trp Leu Arg 
            660                 665                 670         

Glu Thr Asp Arg Val Val Val Asn Asp Asp Leu Arg Ile Ser Ala Ala 
        675                 680                 685             

Lys Ala Glu Val Leu Arg Met Ala Glu Ile Gly Tyr Thr Ala Pro Pro 
    690                 695                 700                 

Lys Ala Lys Glu Ile Arg Val Ala Gly Arg Asp Gly Lys Ala Thr Leu 
705                 710                 715                 720 

Gln Met Ala Ala Arg Ser Met Trp Asn Gly Gly Tyr Ile Thr Asp Tyr 
                725                 730                 735     

Asp Leu His Ile Ala Tyr Lys Leu Ala His Val Leu Ala Gly Gly Asp 
            740                 745                 750         

Val Pro Ala Gly Ser Leu Val Ser Glu Asp Tyr Leu Leu Asp Leu Glu 
        755                 760                 765             

Arg Glu Ala Phe Leu Ser Leu Cys Gly Glu Pro Lys Thr Ile Gln Arg 
    770                 775                 780                 

Met Gln His Met Leu Ala Thr Gly Lys Pro Leu Arg Asn 
785                 790                 795         

<210>   557
<211>   2394
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   557
atgagacaaa ttcgccgagc tgccgtcatt ggttccggcg tgatgggggc gcaaattgcc       60

gctcatctcg ccaacgtggg cattccgagc ctgctgttgg acctcgttcc gcaagagttg      120

actgcggaag aacaaaagaa aggtttgtcg ctcgatcacc cagcggttcg caaccgcctg      180

gcgacggagg ccatccgtag gctgaacaag ctcagcccgg cgcccttgtt ccgcgccgac      240

tacgcgaaac tcatcacgcc tggaaacctc gaggacgacc tgcatcggat ctgcgaggtc      300

gactgggtga ttgaggtcat cgtggagagc ctcgagccca agcgccaact gctcgagcgc      360

atcgagcgat actggcacga gggcatgatt gtgagcacca acacgtcggg catctccatc      420

aacgcgatgg tcgaggggcg aagcgaggcg ttccgccgac acttcctcgg cacgcacttc      480

ttcaatcctc cgcgctacat gaagctgttg gaggtcattc ctggccggga tacggatccc      540

gccatcgtgg agttcatgcg cgactttgga acggagcgcc tcggcaaagg cgtggtgttg      600

gcgaaagaca cgccgaactt catcgccaat cgcatcggca cctacggcct cttggtgacc      660

gtggaggaga tgcaaaaggg cggcttcacc gttgaggagg tcgacgccat caccggtccg      720

gccctcgggc gcccgaagag cgcgaccttc cgcacgctgg atctcgtcgg gatcgacacg      780

tttgtccacg tggccaacaa cgtgcgtcag aacgtgaccg atccacagga acagcgggcg      840

tttgaggtgc cagaggccat ccagaagctc gtggagcgcg gatggctcgg cgagaagagc      900

ggacaaggct tttataagcg cgtgaagcaa aacggccagc gccagatcct cgtgctcgat      960

ctcgacacgt tcgagtaccg cgagcaaaag aagatcgctt cgtcggcgct cgaggcctcg     1020

aagcaggcca aaggggcggc cggaaaggcg aaggcgctcc tccagggcgg cgatcggtac     1080

gcagaactcg cgtggaacat cgtcaagcgc gtgctcgtgt actcggccga gaaactgggc     1140

gagatcgcgg acacgattca ggacatcgac gccgcgatgc gctggggatt caactgggag     1200

ctcgggccgt ttgaactctg ggacgcgctc gggctggtgg agactgccga gcggatgcgc     1260

gcggaagggc tcaggctgcc ctcatgggtc gaggactgga ttgctgcggg gcatcgcgcc     1320

ttctacgaag agaaagacgg caagctgacc atgccggtga acggcaagcc tgagcctgtt     1380

cgggtgccgg ctggggtgat cgatctcgcc gcgctgaaga aggcaggcaa ggtcatcgcg     1440

cagaacaccg gcgcgagcct catcgacctg ggcgacgggg tcgcgtgcct ggagttccat     1500

tcgcagaaca acgccattgg ccccgacatt ctgacgatga tcgaaaagag cgtggccatc     1560

gcggagcgtg acttcgcggg cctggtcatc gcgaaccagg gcaagaactt ctgcgtcggc     1620

gcgaacctca tgctcatcct gatggcagcg caggagggcg actgggacga aattgatctc     1680

tccatccgcc agttccaccg cgccatgctt gcgcttcgct acagccaagt gccggtggtg     1740

gcggcgcctc atcggatgac gctcggcggc ggcgtcgaag tgtgcctggc gtcgtcgagg     1800

gtgctgccgg ccgcggagac ctatttcggg ttggtcgagg tgggcgtcgg cgtcattccg     1860

ggcggcggcg gctgcaagga gacggcgcgc cgcgtggcgg aatcggtcgg ccccgaagac     1920

gatctcgtcc ccgctctagc ccgcatgttc caggccatcg gcaccgccaa ggtgtcgacg     1980

agtggcgccg aggccctggc gatgggctgg ctgcgcgaga cggatcgcgt ggtggtgaac     2040

gacgacctgc gcatctcggc cgcgaaggcg gaggtgcttc gcatggctga gattggctac     2100

accgcgccgc cgaaggcgaa ggaaattcgc gtcgcgggcc gcgacggcaa ggcgaccttg     2160

cagatggccg cgcgcagcat gtggaacggt ggctacatca cggattacga cctccacatc     2220

gcctacaagc tcgcgcatgt gctggcgggc ggcgacgtgc cggcgggctc cctcgtgagc     2280

gaggactacc tgctcgatct cgagcgcgag gcgttcctca gcctgtgcgg agagccgaag     2340

accatccagc gcatgcagca catgctcgcc accgggaagc cgcttcgcaa ctga           2394


<210>   558
<211>   2394
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   558
atgagacaaa ttcgccgagc tgccgtcatt ggttccggcg tgatgggggc gcaaattgcc       60

gctcatctcg ccaacgtggg cattccgagc ctgctgttgg acctcgttcc gcaagagttg      120

actgcggaag aacaaaagaa aggtttgtcg ctcgatcacc cagcggttcg caaccgcctg      180

gcgacggagg ccatccgtag gctgcaaaag ctcagcccgg cgcccttgtt ccgcgccgac      240

tacgcgaaac tcatcacgcc tggaaacctc gaggacgacc tgcatcggat ctgcgaggtc      300

gactgggtga ttgaggtcat cgtggagagc ctcgagccca agcgccaact gctcgagcgc      360

atcgagcgat actggcacga gggcatgatt gtgagcacca acacgtcggg catctccatc      420

aacgcgatgg tcgaggggcg aagcgaggcg ttccgccgac acttcctcgg cacgcacttc      480

ttcaatcctc cgcgctacat gaagctgttg gaggtcattc ctggccggga tacggatccc      540

gccatcgtgg agttcatgcg cgactttgga acggagcgcc tcggcaaagg cgtggtgttg      600

gcgaaagaca cgccgaactt catcgccaat cgcatcggca cctacggcct cttggtgacc      660

gtggaggaga tgcaaaaggg cggcttcacc gttgaggagg tcgacgccat caccggtccg      720

gccctcgggc gcccgaagag cgcgaccttc cgcacgctgg atctcgtcgg gatcgacacg      780

tttgtccacg tggccaacaa cgtgcgtcag aacgtgaccg atccacagga acagcgggcg      840

tttgaggtgc cagaggccat ccagaagctc gtggagcgcg gatggctcgg cgagaagagc      900

ggacaaggct tttataagcg cgtgaagcaa aacggccagc gccagatcct cgtgctcgat      960

ctcgacacgt tcgagtaccg cgagcaaaag aagatcgctt cgtcggcgct cgaggcctcg     1020

aagcaggcca aaggggcggc cggaaaggcg aaggcgctcc tccagggcgg cgatcggtac     1080

gcagaactcg cgtggaacat cgtcaagcgc gtgctcgtgt actcggccga gaaactgggc     1140

gagatcgcgg acacgattca ggacatcgac gccgcgatgc gctggggatt caactgggag     1200

ctcgggccgt ttgaactctg ggacgcgctc gggctggtgg agactgccga gcggatgcgc     1260

gcggaagggc tcaggctgcc ctcatgggtc gaggactgga ttgctgcggg gcatcgcgcc     1320

ttctacgaag agaaagacgg caagctgacc atgccggtga acggcaagcc tgagcctgtt     1380

cgggtgccgg ctggggtgat cgatctcgcc gcgctgaaga aggcaggcaa ggtcatcgcg     1440

cagaacaccg gcgcgagcct catcgacctg ggcgacgggg tcgcgtgcct ggagttccat     1500

tcgcagaaca acgccattgg ccccgacatt ctgacgatga tcgaaaagag cgtggccatc     1560

gcggagaaag acttcgcggg cctggtcatc gcgaaccagg gcaagaactt ctgcgtcggc     1620

gcgaacctca tgctcatcct gatggcagcg caggagggcg actgggacga aattgatctc     1680

tccatccgcc agttccaccg cgccatgctt gcgcttcgct acagccaagt gccggtggtg     1740

gcggcgcctc atcggatgac gctcggcggc ggcgtcgaag tgtgcctggc gtcgtcgagg     1800

gtgctgccgg ccgcggagac ctatttcggg ttggtcgagg tgggcgtcgg cgtcattccg     1860

ggcggcggcg gctgcaagga gacggcgcgc cgcgtggcgg aatcggtcgg ccccgaagac     1920

gatctcgtcc ccgctctagc ccgcatgttc caggccatcg gcaccgccaa ggtgtcgacg     1980

agtggcgccg aggccctggc gatgggctgg ctgcgcgaga cggatcgcgt ggtggtgaac     2040

gacgacctgc gcatctcggc cgcgaaggcg gaggtgcttc gcatggctga gattggctac     2100

accgcgccgc cgaaggcgaa ggaaattcgc gtcgcgggcc gcgacggcaa ggcgaccttg     2160

cagatggccg cgcgcagcat gtggaacggt ggctacatca cggattacga cctccacatc     2220

gcctacaagc tcgcgcatgt gctggcgggc ggcgacgtgc cggcgggctc cctcgtgagc     2280

gaggactacc tgctcgatct cgagcgcgag gcgttcctca gcctgtgcgg agagccgaag     2340

accatccagc gcatgcagca catgctcgcc accgggaagc cgcttcgcaa ctga           2394


<210>   559
<211>   2394
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   559
atgagacaaa ttcgccgagc tgccgtcatt ggttccggcg tgatgggggc gcaaattgcc       60

gctcatctcg ccaacgtggg cattccgagc ctgctgttgg acctcgttcc gcaagagttg      120

actgcggaag aacaaaagaa aggtttgtcg ctcgatcacc cagcggttcg caaccgcctg      180

gcgacggagg ccatccgtag gctgaacaag ctcagcccgg cgcccttgtt ccgcgccgac      240

tacgcgaaac tcatcacgcc tggaaacctc gaggacgacc tgcatcggat ctgcgaggtc      300

gactgggtga ttgaggtcat cgtggagagc ctcgagccca agcgccaact gctcgagcgc      360

atcgagcgat actggcacga gggcatgatt gtgagcacca acacgtcggg catctccatc      420

aacgcgatgg tcgaggggcg aagcgaggcg ttccgccgac acttcctcgg cacgcacttc      480

ttcaatcctc cgcgctacat gaagctgttg gaggtcattc ctggccggga tacggatccc      540

gccatcgtgg agttcatgcg cgactttgga acggagcgcc tcggcaaagg cgtggtgttg      600

gcgaaagaca cgccgaactt catcgccaat cgcatcggca cctacggcct cttggtgacc      660

gtggaggaga tgcaaaaggg cggcttcacc gttgaggagg tcgacgccat caccggtccg      720

gccctcgggc gcccgaagag cgcgaccttc cgcacgctgg atctcgtcgg gatcgacacg      780

tttgtccacg tggccaacaa cgtgcgtcag aacgtgaccg atccacagga acagcgggcg      840

tttgaggtgc cagaggccat ccagaagctc gtggagcgcg gatggctcgg cgagaagagc      900

ggacaaggct tttataagcg cgtgaagcaa aacggccagc gccagatcct cgtgctcgat      960

ctcgacacgt tcgagtaccg cgagcaaaag aagatcgctt cgtcggcgct cgaggcctcg     1020

aagcaggcca aaggggcggc cggaaaggcg aaggcgctcc tccagggcgg cgatcggtac     1080

gcagaactcg cgtggaacat cgtcaagcgc gtgctcgtgt actcggccga gaaactgggc     1140

gagatcgcgg acacgattca ggacatcgac gccgcgatgc gctggggatt caactgggag     1200

ctcgggccgt ttgaactctg ggacgcgctc gggctggtgg agactgccga gcggatgcgc     1260

gcggaagggc tcaggctgcc ctcatgggtc gaggactgga ttgctgcggg gcatcgcgcc     1320

ttctacgaag agaaagacgg caagctgacc atgccggtga acggcaagcc tgagcctgtt     1380

cgggtgccgg ctggggtgat cgatctcgcc gcgctgaaga aggcaggcaa ggtcatcgcg     1440

cagaacaccg gcgcgagcct catcgacctg ggcgacgggg tcgcgtgcct ggagttccat     1500

tcgcagaaca acgccattgg ccccgacatt ctgacgatga tcgaaaagag cgtggccatc     1560

gcggagaaag acttcgcggg cctggtcatc gcgaaccagg gcaagaactt ctgcgtcggc     1620

gcgaacctca tgctcatcct gatggcagcg caggagggcg actgggaaga aattgatctc     1680

tccatccgcc agttccaccg cgccatgctt gcgcttcgct acagccaagt gccggtggtg     1740

gcggcgcctc atcggatgac gctcggcggc ggcgtcgaag tgtgcctggc gtcgtcgagg     1800

gtgctgccgg ccgcggagac ctatttcggg ttggtcgagg tgggcgtcgg cgtcattccg     1860

ggcggcggcg gctgcaagga gacggcgcgc cgcgtggcgg aatcggtcgg ccccgaagac     1920

gatctcgtcc ccgctctagc ccgcatgttc caggccatcg gcaccgccaa ggtgtcgacg     1980

agtggcgccg aggccctggc gatgggctgg ctgcgcgaga cggatcgcgt ggtggtgaac     2040

gacgacctgc gcatctcggc cgcgaaggcg gaggtgcttc gcatggctga gattggctac     2100

accgcgccgc cgaaggcgaa ggaaattcgc gtcgcgggcc gcgacggcaa ggcgaccttg     2160

cagatggccg cgcgcagcat gtggaacggt ggctacatca cggattacga cctccacatc     2220

gcctacaagc tcgcgcatgt gctggcgggc ggcgacgtgc cggcgggctc cctcgtgagc     2280

gaggactacc tgctcgatct cgagcgcgag gcgttcctca gcctgtgcgg agagccgaag     2340

accatccagc gcatgcagca catgctcgcc accgggaagc cgcttcgcaa ctga           2394


<210>   560
<211>   2394
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   560
atgagacaaa ttcgccgagc tgccgtcatt ggttccggcg tgatgggggc gcaaattgcc       60

gctcatctcg ccaacgtggg cattccgagc ctgctgttgg acctcgttcc gcaagagttg      120

actgcggaag aacaaaagaa aggtttgtcg ctcgatcacc cagcggttcg caaccgcctg      180

gcgacggagg ccatccgtag gctgaacaag ctcagcccgg cgcccttgtt ccgcgccgac      240

tacgcgaaac tcatcacgcc tggaaacctc gaggacgacc tgcatcggat ctgcgaggtc      300

gactgggtga ttgaggtcat cgtggagagc ctcgagccca agcgccaact gctcgagcgc      360

atcgagcgat actggcacga gggcatgatt gtgagcacca acacgtcggg catctccatc      420

aacgcgatgg tcgaggggcg aagcgaggcg ttccgccgac acttcctcgg cacgcacttc      480

ttcaatcctc cgcgctacat gaagctgttg gaggtcattc ctggccggga tacggatccc      540

gccatcgtgg agttcatgcg cgactttgga acggagcgcc tcggcaaagg cgtggtgttg      600

gcgaaagaca cgccgaactt catcgccaat cgcatcggca cctacggcct cttggtgacc      660

gtggaggaga tgcaaaaggg cggcttcacc gttgaggagg tcgacgccat caccggtccg      720

gccctcgggc gcccgaagag cgcgaccttc cgcacgctgg atctcgtcgg gatcgacacg      780

tttgtccacg tggccaacaa cgtgcgtcag aacgtgaccg atccacagga acagcgggcg      840

tttgaggtgc cagaggccat ccagaagctc gtggagcgcg gatggctcgg cgagaagagc      900

ggacaaggct tttataagcg cgtgaagcaa aacggccagc gccagatcct cgtgctcgat      960

ctcgacacgt tcgagtaccg cgagcaaaag aagatcgctt cgtcggcgct cgaggcctcg     1020

aagcaggcca aaggggcggc cggaaaggcg aaggcgctcc tccagggcgg cgatcggtac     1080

gcagaactcg cgtggaacat cgtcaagcgc gtgctcgtgt actcggccga gaaactgggc     1140

gagatcgcgg acacgattca ggacatcgac gccgcgatgc gctggggatt caactgggag     1200

ctcgggccgt ttgaactctg ggacgcgctc gggctggtgg agactgccga gcggatgcgc     1260

gcggaagggc tcaggctgcc ctcatgggtc gaggactgga ttgctgcggg gcatcgcgcc     1320

ttctacgaag agaaagacgg caagctgacc atgccggtga acggcaagcc tgagcctgtt     1380

cgggtgccgg ctggggtgat cgatctcgcc gcgctgaaga aggcaggcaa ggtcatcgcg     1440

cagaacaccg gcgcgagcct catcgacctg ggcgacgggg tcgcgtgcct ggagttccat     1500

tcgcagaaca acgccattgg ccccgacatt ctgacgatga tcgaaaagag cgtggccatc     1560

gcggagaaag acttcgcggg cctggtcatc gcgaaccagg gcaagaactt ctgcgtcggc     1620

gcgaacctca tgctcatcct gatggcagcg caggagggcg actgggacga aattgatctc     1680

tccatccgcc agttccaccg cgccatgctt gcgcttcgct acagcaatgt gccggtggtg     1740

gcggcgcctc atcggatgac gctcggcggc ggcgtcgaag tgtgcctggc gtcgtcgagg     1800

gtgctgccgg ccgcggagac ctatttcggg ttggtcgagg tgggcgtcgg cgtcattccg     1860

ggcggcggcg gctgcaagga gacggcgcgc cgcgtggcgg aatcggtcgg ccccgaagac     1920

gatctcgtcc ccgctctagc ccgcatgttc caggccatcg gcaccgccaa ggtgtcgacg     1980

agtggcgccg aggccctggc gatgggctgg ctgcgcgaga cggatcgcgt ggtggtgaac     2040

gacgacctgc gcatctcggc cgcgaaggcg gaggtgcttc gcatggctga gattggctac     2100

accgcgccgc cgaaggcgaa ggaaattcgc gtcgcgggcc gcgacggcaa ggcgaccttg     2160

cagatggccg cgcgcagcat gtggaacggt ggctacatca cggattacga cctccacatc     2220

gcctacaagc tcgcgcatgt gctggcgggc ggcgacgtgc cggcgggctc cctcgtgagc     2280

gaggactacc tgctcgatct cgagcgcgag gcgttcctca gcctgtgcgg agagccgaag     2340

accatccagc gcatgcagca catgctcgcc accgggaagc cgcttcgcaa ctga           2394


<210>   561
<211>   2394
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   561
atgagacaaa ttcgccgagc tgccgtcatt ggttccggcg tgatgggggc gcaaattgcc       60

gctcatctcg ccaacgtggg cattccgagc ctgctgttgg acctcgttcc gcaagagttg      120

actgcggaag aacaaaagaa aggtttgtcg ctcgatcacc cagcggttcg caaccgcctg      180

gcgacggagg ccatccgtag gctgaacaag ctcagcccgg cgcccttgtt ccgcgccgac      240

tacgcgaaac tcatcacgcc tggaaacctc gaggacgacc tgcatcggat ctgcgaggtc      300

gactgggtga ttgaggtcat cgtggagagc ctcgagccca agcgccaact gctcgagcgc      360

atcgagcgat actggcacga gggcatgatt gtgagcacca acacgtcggg catctccatc      420

aacgcgatgg tcgaggggcg aagcgaggcg ttccgccgac acttcctcgg cacgcacttc      480

ttcaatcctc cgcgctacat gaagctgttg gaggtcattc ctggccggga tacggatccc      540

gccatcgtgg agttcatgcg cgactttgga acggagcgcc tcggcaaagg cgtggtgttg      600

gcgaaagaca cgccgaactt catcgccaat cgcatcggca cctacggcct cttggtgacc      660

gtggaggaga tgcaaaaggg cggcttcacc gttgaggagg tcgacgccat caccggtccg      720

gccctcgggc gcccgaagag cgcgaccttc cgcacgctgg atctcgtcgg gatcgacacg      780

tttgtccacg tggccaacaa cgtgcgtcag aacgtgaccg atccacagga acagcgggcg      840

tttgaggtgc cagaggccat ccagaagctc gtggagcgcg gatggctcgg cgagaagagc      900

ggacaaggct tttataagcg cgtgaagcaa aacggccagc gccagatcct cgtgctcgat      960

ctcgacacgt tcgagtaccg cgagcaaaag aagatcgctt cgtcggcgct cgaggcctcg     1020

aagcaggcca aaggggcggc cggaaaggcg aaggcgctcc tccagggcgg cgatcggtac     1080

gcagaactcg cgtggaacat cgtcaagcgc gtgctcgtgt actcggccga gaaactgggc     1140

gagatcgcgg acacgattca ggacatcgac gccgcgatgc gctggggatt caactgggag     1200

ctcgggccgt ttgaactctg ggacgcgctc gggctggtgg agactgccga gcggatgcgc     1260

gcggaagggc tcaggctgcc ctcatgggtc gaggactgga ttgctgcggg gcatcgcgcc     1320

ttctacgaag agaaagacgg caagctgacc atgccggtga acggcaagcc tgagcctgtt     1380

cgggtgccgg ctggggtgat cgatctcgcc gcgctgaaga aggcaggcaa ggtcatcgcg     1440

cagaacaccg gcgcgagcct catcgacctg ggcgacgggg tcgcgtgcct ggagttccat     1500

tcgcagaaca acgccattgg ccccgacatt ctgacgatga tcgaaaagag cgtggccatc     1560

gcggagaaag acttcgcggg cctggtcatc gcgaaccagg gcaagaactt ctgcgtcggc     1620

gcgaacctca tgctcatcct gatggcagcg caggagggcg actgggacga aattgatctc     1680

tccatccgcc agttccaccg cgccatgctt gcgcttcgct acagccaagt gccggtggtg     1740

gcggcgcctc atcggatgac gctcggcggc ggcgtcgaag tgtgcctggc gtcgtcgagg     1800

gtgctgccgg ccgcggagac ctatttcggg ttggtcgagg tgggcgtcgg cgtcattccg     1860

ggcggcggcg gctgcaagga gacggcgcgc cgcattgcgg aatcggtcgg ccccgaagac     1920

gatctcgtcc ccgctctagc ccgcatgttc caggccatcg gcaccgccaa ggtgtcgacg     1980

agtggcgccg aggccctggc gatgggctgg ctgcgcgaga cggatcgcgt ggtggtgaac     2040

gacgacctgc gcatctcggc cgcgaaggcg gaggtgcttc gcatggctga gattggctac     2100

accgcgccgc cgaaggcgaa ggaaattcgc gtcgcgggcc gcgacggcaa ggcgaccttg     2160

cagatggccg cgcgcagcat gtggaacggt ggctacatca cggattacga cctccacatc     2220

gcctacaagc tcgcgcatgt gctggcgggc ggcgacgtgc cggcgggctc cctcgtgagc     2280

gaggactacc tgctcgatct cgagcgcgag gcgttcctca gcctgtgcgg agagccgaag     2340

accatccagc gcatgcagca catgctcgcc accgggaagc cgcttcgcaa ctga           2394


<210>   562
<211>   360
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   562
Met His Ile Cys Phe Glu Ser Ala Glu Glu Val Glu Gly Met Gln Val 
                5                   10                  15      

Lys Ala Arg Gly Val Leu Ser Lys Glu Ser Pro Phe His Ala Ile Lys 
            20                  25                  30          

Ile Glu Arg Arg Glu Leu Gln Pro Asp Asp Val Leu Ile Glu Ile His 
        35                  40                  45              

Tyr Cys Gly Ile Cys His Ser Asp Ile His Ser Ala Arg Gly Glu Trp 
    50                  55                  60                  

Gly Glu Val Arg Tyr Pro Phe Val Pro Gly His Glu Ile Thr Gly Ile 
65                  70                  75                  80  

Val Ser Lys Val Gly Ser Gln Val Thr Lys Phe Lys Pro Gly Asp Arg 
                85                  90                  95      

Val Gly Val Gly Cys Met Val Asp Ser Cys Gly Glu Cys Glu Asn Cys 
            100                 105                 110         

Lys Arg Gly Asp Glu Gln Tyr Cys Val Lys Gly Asn Ile Gln Thr Tyr 
        115                 120                 125             

Gly Ser Val Asp Arg Tyr Gly Gln Tyr Thr Met Gly Gly Tyr Ser Thr 
    130                 135                 140                 

His Ile Val Val Lys Glu Asp Phe Val Leu Arg Ile Pro Asp Ala Leu 
145                 150                 155                 160 

Pro Leu Asp Lys Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
                165                 170                 175     

Ser Pro Leu Arg His Trp Gln Ala Gly Pro Gly Lys Glu Val Ala Val 
            180                 185                 190         

Val Gly Leu Gly Gly Leu Gly His Met Ala Val Lys Leu Ala Lys Ala 
        195                 200                 205             

Met Gly Ala Lys Val Thr Val Leu Ser Gln Ser Leu Arg Lys Lys Glu 
    210                 215                 220                 

Asp Gly Leu Arg Leu Gly Ala Lys Ala Tyr Tyr Ala Thr Ser Asp Pro 
225                 230                 235                 240 

Glu Thr Phe Arg Gln Leu Ala Gly Arg Phe Asp Leu Ile Ile Asn Thr 
                245                 250                 255     

Val Ser Ala Lys Ile Pro Ile Thr Glu Tyr Leu Gly Leu Leu Lys Thr 
            260                 265                 270         

Asp Gly Ala Leu Val Asn Val Gly Ala Pro Pro Glu Pro Leu Glu Val 
        275                 280                 285             

Asn Ala Phe Ala Leu Ile Ala Gln Arg Arg Thr Phe Ala Gly Ser Cys 
    290                 295                 300                 

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asp Phe Cys Ala Glu 
305                 310                 315                 320 

Ser Gly Val Thr Pro Glu Ile Glu Val Ile Ser Ala Asp Glu Ile Asp 
                325                 330                 335     

Ala Ala Trp Glu Arg Val Leu Lys Ser Asp Val Arg Tyr Arg Phe Val 
            340                 345                 350         

Ile Asp Ile Ser Thr Met Arg Asn 
        355                 360 

<210>   563
<211>   1083
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   563
ttgcacatct gtttcgaatc ggcagaggag gtcgaaggga tgcaggtcaa ggctcgcggc       60

gtgttgagca aggagagccc gtttcatgcc atcaagatcg agcggcggga gcttcagccc      120

gacgatgtgc tgattgaaat ccactactgc ggcatctgcc actccgacat ccactcggcc      180

cgcggcgagt ggggcgaggt gcggtatcca ttcgtgcccg ggcatgagat caccggcatc      240

gtctcgaagg tcggcagcca ggtgaccaag ttcaagccgg gcgatcgcgt cggcgtggga      300

tgcatggtcg actcgtgcgg cgaatgcgag aactgtaagc gcggcgacga gcagtactgc      360

gtgaagggca acatccagac gtacggcagt gtcgaccgct acgggcagta caccatgggc      420

ggctactcca cgcacatcgt ggtgaaggag gacttcgtcc tccgcatccc ggatgcgctg      480

cctctggaca aggcggcgcc gcttctgtgc gcgggcatca cgacgtactc gccgcttcgc      540

cactggcagg cgggcccggg aaaggaggtc gccgtcgtcg gcctcggggg gctcggtcac      600

atggccgtga agctcgcgaa ggcgatgggg gcgaaggtca ccgtgctctc ccagtccctg      660

cggaaaaagg aggacggcct gcgcctcggc gcgaaagcct actacgcgac gagcgatccc      720

gagacattcc gccagctcgc cggacgcttc gatctcatca tcaacacggt gtcggcgaag      780

atccccatca ctgagtatct gggccttctg aagacggatg gcgctctggt caacgtcggc      840

gcgccgccgg agccgctcga ggtgaacgcg tttgcgctca tcgcacagcg ccgcacgttt      900

gcgggctcct gcatcggcgg catccgcgag acgcaggaga tgctcgattt ctgcgctgag      960

agcggtgtga cgcccgagat cgaggtcatc tcggcggacg agatcgacgc ggcgtgggag     1020

cgggtgctga agtcggacgt gcggtatcga ttcgtgatcg acatcagcac gatgcgcaat     1080

tga                                                                   1083


<210>   564
<211>   342
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   564
Lys Ala Arg Ala Val Asp Gly Pro His Gln Pro Phe His Ala Thr Glu 
                5                   10                  15      

Ile Lys Arg Arg Asn Leu Asp Ser His Asp Val Leu Ile Glu Ile Lys 
            20                  25                  30          

Tyr Ser Gly Ile Cys His Ser Asp Ile His Thr Ala His Gly Glu Trp 
        35                  40                  45              

Gly Glu Val Asn Tyr Pro Leu Val Pro Gly His Glu Ile Ala Gly Val 
    50                  55                  60                  

Val Ser Asp Val Gly Pro Glu Val Thr Lys Tyr Lys Val Gly Asp Arg 
65                  70                  75                  80  

Val Gly Val Gly Cys Met Val Asp Ser Cys Gly Glu Cys Glu Asn Cys 
                85                  90                  95      

Arg Arg Gly Glu Glu Gln Tyr Cys His Gln Gly Asn Val Gln Thr Tyr 
            100                 105                 110         

Gly Gly Val Asp Lys Tyr Gly Glu Pro Thr Gln Gly Gly Tyr Ser Thr 
        115                 120                 125             

His Ile Val Val Thr Glu Asp Phe Val Leu Arg Ile Pro Asp Asn Ile 
    130                 135                 140                 

Glu Leu Asp Val Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
145                 150                 155                 160 

Ser Pro Leu Asn His Trp Asn Ala Gly Pro Gly Lys Lys Val Ala Val 
                165                 170                 175     

Val Gly Met Gly Gly Leu Gly His Met Ala Val Lys Ile Ala His Ala 
            180                 185                 190         

Met Gly Ala Glu Val Thr Val Leu Ser Arg Thr Leu Asn Lys Lys Glu 
        195                 200                 205             

Asp Gly Leu Glu Phe Gly Ala Glu Asn Tyr Tyr Ala Thr Ser Glu Lys 
    210                 215                 220                 

Glu Thr Phe Glu Thr Leu Ala Gly Ser Phe Asp Leu Ile Ile Asn Thr 
225                 230                 235                 240 

Val Ser Ala Lys Leu Asp Met Asp Ala Tyr Phe Ser Leu Leu Asn Leu 
                245                 250                 255     

Asp Gly Ser Leu Val Asn Val Gly Ala Pro Ala Glu Pro Leu Ser Val 
            260                 265                 270         

Asn Val Phe Ser Leu Ile Gly His Arg Arg Ser Phe Ala Gly Ser Leu 
        275                 280                 285             

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asp Phe Cys Ala Glu 
    290                 295                 300                 

His Asn Ile Val Pro Lys Ile Glu Val Ile Ser Ala Asp Gln Ile Asp 
305                 310                 315                 320 

Glu Ala Tyr Thr Arg Val Leu Asp Ser Asp Val Lys Tyr Arg Phe Val 
                325                 330                 335     

Ile Asp Val Ser Thr Ile 
            340         

<210>   565
<211>   326
<212>   PRT
<213>   Arthrobacter sp. FB24

<400>   565
Ile Glu Arg Arg Asp Val Gly Pro His Asp Val Leu Ile Gly Ile Lys 
                5                   10                  15      

Phe Ala Gly Ile Cys His Ser Asp Ile His Thr Val Arg Gly Asp Trp 
            20                  25                  30          

Gly Pro Gln Gln Tyr Pro Leu Ala Pro Gly His Glu Ile Ala Gly Ile 
        35                  40                  45              

Val Thr Asp Val Gly Ser Glu Val Thr Lys His Ala Val Gly Asp Arg 
    50                  55                  60                  

Val Gly Val Gly Cys Met Val Asn Ser Cys Arg Glu Cys Val Asn Cys 
65                  70                  75                  80  

Gln Lys Gly Glu Glu Gln Tyr Cys Leu Lys Gly Asn Ile Gly Thr Tyr 
                85                  90                  95      

Gly Ala Val Asp Arg Asp Gly Thr Ile Thr Gln Gly Gly Tyr Ser Thr 
            100                 105                 110         

His Val Val Val Thr Glu Asp Phe Val Val Arg Ile Pro Glu Gly Ile 
        115                 120                 125             

Glu Leu Asp Val Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
    130                 135                 140                 

Ser Pro Leu His His Trp Gly Ala Gly Pro Gly Lys Lys Val Ala Val 
145                 150                 155                 160 

Val Gly Leu Gly Gly Leu Gly His Met Ala Val Lys Ile Ala His Ala 
                165                 170                 175     

Met Gly Ala Glu Val Thr Val Leu Ser Gln Ser Leu Lys Lys Gln Glu 
            180                 185                 190         

Asp Gly Leu Lys Leu Gly Ala Asp His Tyr Tyr Ala Thr Ser Asp Glu 
        195                 200                 205             

Asn Thr Phe Ser Asp Leu Ala Gly Ser Phe Asp Leu Ile Ile Asn Thr 
    210                 215                 220                 

Val Ser Ala Ser Ile Asp Ile Ser Ser Tyr Leu Gln Leu Leu Thr Leu 
225                 230                 235                 240 

Asp Gly Ala Leu Val Asn Val Gly Ala Pro Ala Glu Pro Leu Pro Val 
                245                 250                 255     

Asn Ala Phe Ala Leu Ile Ala Gly Arg Arg Ser Phe Ala Gly Ser Met 
            260                 265                 270         

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asp Phe Cys Ala Glu 
        275                 280                 285             

His Asn Leu Gly Ala Glu Ile Glu Val Ile Pro Ala Glu Lys Ile Asn 
    290                 295                 300                 

Glu Ala Tyr Glu Arg Val Leu Ala Ser Asp Val Arg Tyr Arg Phe Val 
305                 310                 315                 320 

Ile Asp Thr Ala Thr Leu 
                325     

<210>   566
<211>   326
<212>   PRT
<213>   Arthrobacter aurescens TC1

<400>   566
Ile Glu Arg Arg Glu Val Gly Pro Asn Asp Val His Ile Asp Ile Lys 
                5                   10                  15      

Phe Ala Gly Ile Cys His Ser Asp Ile His Thr Val Arg Gly Asp Trp 
            20                  25                  30          

Gly Pro Gln Gln Tyr Pro Leu Ala Pro Gly His Glu Ile Ala Gly Ile 
        35                  40                  45              

Val Thr Glu Val Gly Ser Asp Val Thr Lys His Lys Val Gly Asp Arg 
    50                  55                  60                  

Val Gly Val Gly Cys Met Val Asn Ser Cys Lys Glu Cys Lys Asn Cys 
65                  70                  75                  80  

Leu Ala Gly Glu Glu Gln Tyr Cys Leu Lys Gly Asn Val Gly Thr Tyr 
                85                  90                  95      

Gly Ser Val Asp Arg Asp Gly Thr Ile Thr Gln Gly Gly Tyr Ser Ser 
            100                 105                 110         

His Val Val Val Asn Glu Asp Phe Val Val Thr Ile Pro Glu Gly Leu 
        115                 120                 125             

Asp Leu Asp Val Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
    130                 135                 140                 

Ser Pro Leu His His Trp Gly Ala Gly Pro Gly Lys Lys Val Ala Val 
145                 150                 155                 160 

Val Gly Leu Gly Gly Leu Gly His Met Ala Val Lys Ile Ala His Ala 
                165                 170                 175     

Met Gly Ala Glu Val Thr Val Leu Ser Gln Ser Leu Lys Lys Met Glu 
            180                 185                 190         

Asp Gly Leu Lys Leu Gly Ala Asp His Tyr Tyr Ala Thr Ser Asp Pro 
        195                 200                 205             

Ala Thr Phe Glu Gln Leu Gly Gly Thr Phe Asp Leu Ile Val Asn Thr 
    210                 215                 220                 

Val Ser Ala Ser Ile Asp Ile Ser Ala Tyr Leu Gln Leu Leu Thr Leu 
225                 230                 235                 240 

Asp Gly Thr Leu Val Asn Val Gly Ala Pro Ala Glu Pro Leu Pro Val 
                245                 250                 255     

Asn Val Phe Ser Leu Ile Thr Gly Arg Arg Arg Phe Ala Gly Ser Ala 
            260                 265                 270         

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asn Phe Cys Ala Glu 
        275                 280                 285             

His Gly Leu Gly Ala Glu Ile Glu Val Ile Pro Ala Ser Lys Ile Asn 
    290                 295                 300                 

Asp Ala Tyr Glu Arg Val Leu Ala Ser Asp Val Arg Tyr Arg Phe Val 
305                 310                 315                 320 

Ile Asp Val Ser Thr Ile 
                325     

<210>   567
<211>   343
<212>   PRT
<213>   Clavibacter michiganensis subsp. michiganensis NCPPB 382

<400>   567
Val Asn Ala Tyr Ala Ala Thr Ser Ala Thr Asp Pro Ile Thr Lys Thr 
                5                   10                  15      

Thr Ile Glu Arg Arg Asp Val Gly Pro Lys Asp Val Ser Ile Asp Ile 
            20                  25                  30          

Ala Tyr Ser Gly Val Cys His Ser Asp Ile His Thr Val Arg Gly Glu 
        35                  40                  45              

Trp Gly Pro Ile Ala Tyr Pro Gln Val Val Gly His Glu Ile Val Gly 
    50                  55                  60                  

Arg Val Thr Glu Val Gly Ser Glu Val Ser Lys His Glu Val Gly Asp 
65                  70                  75                  80  

Leu Val Gly Val Gly Cys Met Val Asn Ser Cys Lys Glu Cys Glu Gln 
                85                  90                  95      

Cys Lys Ala Gly Gln Glu Gln Tyr Cys Leu Lys Gly Asn Ile Gln Thr 
            100                 105                 110         

Tyr Gly Gly Thr Asp Pro Ala Asp Gly Thr Ile Thr Gln Gly Gly Tyr 
        115                 120                 125             

Ser Glu Ala Val Val Val Asp Glu Asp Phe Val Leu Arg Val Pro Glu 
    130                 135                 140                 

Ser Leu Asp Ile Glu Lys Val Ala Pro Leu Leu Cys Ala Gly Ile Thr 
145                 150                 155                 160 

Thr Tyr Ser Pro Leu Arg His Trp Asn Ala Gly Pro Gly Thr Lys Val 
                165                 170                 175     

Ala Val Val Gly Met Gly Gly Leu Gly His Met Ala Val Lys Ile Ala 
            180                 185                 190         

His Ala Met Gly Ala Glu Val Thr Val Leu Ser Gln Thr Leu Ser Lys 
        195                 200                 205             

Lys Glu Asp Gly Leu Arg Leu Gly Ala Asp Arg Tyr Phe Ala Thr Ser 
    210                 215                 220                 

Asp Asp Ala Thr Phe Thr Glu Leu Ala Ser Ser Phe Asp Leu Ile Ile 
225                 230                 235                 240 

Asn Thr Val Ser Ala Lys Leu Asp Met Ser Lys Tyr Ile Gly Leu Leu 
                245                 250                 255     

Ala Ile Asp Gly Thr Leu Val Asn Val Gly Ala Pro Ser Glu Pro Leu 
            260                 265                 270         

Glu Ile Pro Ala Phe Ala Leu Ile Pro Ala Arg Arg Ser Trp Ala Gly 
        275                 280                 285             

Ser Met Ile Gly Gly Ile Ala Glu Thr Gln Glu Met Leu Asp Phe Cys 
    290                 295                 300                 

Ala Glu His Gly Ile Val Pro Glu Thr Glu Leu Ile Ser Ala Glu Gln 
305                 310                 315                 320 

Ile Asn Glu Ala Tyr Glu Arg Val Leu Lys Ser Asp Val Arg Tyr Arg 
                325                 330                 335     

Phe Val Ile Asp Ala Lys Thr 
            340             

<210>   568
<211>   346
<212>   PRT
<213>   Mycobacterium smegmatis str. MC2 155

<400>   568
Val Ser Ala Tyr Ala Ala Thr Ser Ala Thr Glu Pro Leu Thr Lys Thr 
                5                   10                  15      

Thr Ile Thr Arg Arg Ala Val Gly Pro His Asp Val Ala Phe Asp Ile 
            20                  25                  30          

His Phe Ala Gly Ile Cys His Ser Asp Ile His Thr Val Lys Ala Glu 
        35                  40                  45              

Trp Gly Val Pro Asn Tyr Pro Val Val Pro Gly His Glu Ile Ala Gly 
    50                  55                  60                  

Val Val Thr Glu Val Gly Ser Glu Val Thr Lys Tyr Lys Val Gly Asp 
65                  70                  75                  80  

Arg Val Gly Val Gly Cys Phe Val Asp Ser Cys Arg Glu Cys Asp Asn 
                85                  90                  95      

Cys Lys Ala Gly Leu Glu Gln Tyr Cys Thr Gly Thr Gly Met Val Gly 
            100                 105                 110         

Thr Tyr Asn Ala Ile Asp Arg Asp Gly Thr Pro Thr His Gly Gly Tyr 
        115                 120                 125             

Ser Gly Ala Ile Val Val Asp Glu Asn Tyr Val Leu Arg Ile Pro Asp 
    130                 135                 140                 

Ser Leu Pro Leu Asp Ala Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr 
145                 150                 155                 160 

Thr Tyr Ser Pro Leu Arg His Trp Asn Ala Gly Pro Gly Lys Lys Val 
                165                 170                 175     

Ala Val Ile Gly Leu Gly Gly Leu Gly His Val Ala Val Lys Leu Ala 
            180                 185                 190         

Lys Ala Met Gly Ala Asp Val Thr Val Leu Ser Gln Ser Leu Lys Lys 
        195                 200                 205             

Met Glu Asp Gly Leu Arg Leu Gly Ala Ser Ala Tyr Tyr Ala Thr Ser 
    210                 215                 220                 

Asp Pro Glu Thr Phe Asp Lys Leu Ala Gly Ser Phe Asp Leu Ile Leu 
225                 230                 235                 240 

Asn Thr Val Ser Ala Asn Leu Asp Leu Gly Ala Tyr Leu Gly Leu Leu 
                245                 250                 255     

Lys Leu Asp Gly Ala Leu Val Glu Leu Gly Leu Pro Glu His Pro Met 
            260                 265                 270         

Glu Val Pro Ala Phe Pro Leu Leu Ala Gln Arg Arg Asn Leu Thr Gly 
        275                 280                 285             

Ser Met Ile Gly Gly Ile Pro Glu Thr Gln Glu Met Leu Asp Phe Cys 
    290                 295                 300                 

Ala Glu His Asp Val Arg Pro Glu Ile Glu Ile Ile Thr Pro Asp Tyr 
305                 310                 315                 320 

Ile Asn Glu Ala Tyr Glu Arg Val Leu Ala Ser Asp Val Arg Tyr Arg 
                325                 330                 335     

Phe Val Ile Asp Thr Ala Ser Leu Arg Ser 
            340                 345     

<210>   569
<211>   360
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   569
Met His Ile Cys Phe Glu Ser Ala Glu Glu Val Glu Gly Met Gln Val 
                5                   10                  15      

Lys Ala Arg Gly Val Leu Ser Lys Glu Ser Pro Phe His Ala Leu Lys 
            20                  25                  30          

Ile Glu Arg Arg Glu Leu Gln Pro Asp Asp Val Leu Ile Glu Ile His 
        35                  40                  45              

Tyr Cys Gly Ile Cys His Ser Asp Ile His Ser Ala Arg Gly Glu Trp 
    50                  55                  60                  

Gly Glu Val Arg Tyr Pro Phe Val Pro Gly His Glu Ile Thr Gly Ile 
65                  70                  75                  80  

Val Ser Lys Val Gly Ser Gln Val Thr Lys Phe Lys Pro Gly Asp Arg 
                85                  90                  95      

Val Gly Val Gly Cys Met Val Asp Ser Cys Gly Glu Cys Glu Asn Cys 
            100                 105                 110         

Lys Arg Gly Asp Glu Gln Tyr Cys Val Lys Gly Asn Ile Gln Thr Tyr 
        115                 120                 125             

Gly Ser Val Asp Arg Tyr Gly Gln Tyr Thr Met Gly Gly Tyr Ser Thr 
    130                 135                 140                 

His Ile Val Val Lys Glu Asp Phe Val Leu Arg Ile Pro Asp Ala Leu 
145                 150                 155                 160 

Pro Leu Asp Lys Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
                165                 170                 175     

Ser Pro Leu Arg His Trp Gln Ala Gly Pro Gly Lys Glu Val Ala Val 
            180                 185                 190         

Val Gly Leu Gly Gly Leu Gly His Met Ala Val Lys Leu Ala Lys Ala 
        195                 200                 205             

Met Gly Ala Lys Val Thr Val Leu Ser Gln Ser Leu Arg Lys Lys Glu 
    210                 215                 220                 

Asp Gly Leu Arg Leu Gly Ala Lys Ala Tyr Tyr Ala Thr Ser Asp Pro 
225                 230                 235                 240 

Glu Thr Phe Arg Gln Leu Ala Gly Arg Phe Asp Leu Ile Ile Asn Thr 
                245                 250                 255     

Val Ser Ala Lys Ile Pro Ile Thr Glu Tyr Leu Gly Leu Leu Lys Thr 
            260                 265                 270         

Asp Gly Ala Leu Val Asn Val Gly Ala Pro Pro Glu Pro Leu Glu Val 
        275                 280                 285             

Asn Ala Phe Ala Leu Ile Ala Gln Arg Arg Thr Phe Ala Gly Ser Cys 
    290                 295                 300                 

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asp Phe Cys Ala Glu 
305                 310                 315                 320 

Ser Gly Val Thr Pro Glu Ile Glu Val Ile Ser Ala Asp Glu Ile Asp 
                325                 330                 335     

Ala Ala Trp Glu Arg Val Leu Lys Ser Asp Val Arg Tyr Arg Phe Val 
            340                 345                 350         

Ile Asp Ile Ser Thr Met Arg Asn 
        355                 360 

<210>   570
<211>   360
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   570
Met His Ile Cys Phe Glu Ser Ala Glu Glu Val Glu Gly Met Gln Ile 
                5                   10                  15      

Lys Ala Arg Gly Val Leu Ser Lys Glu Ser Pro Phe His Ala Ile Lys 
            20                  25                  30          

Ile Glu Arg Arg Glu Leu Gln Pro Asp Asp Val Leu Ile Glu Ile His 
        35                  40                  45              

Tyr Cys Gly Ile Cys His Ser Asp Ile His Ser Ala Arg Gly Glu Trp 
    50                  55                  60                  

Gly Glu Val Arg Tyr Pro Phe Val Pro Gly His Glu Ile Thr Gly Ile 
65                  70                  75                  80  

Val Ser Lys Val Gly Ser Gln Val Thr Lys Phe Lys Pro Gly Asp Arg 
                85                  90                  95      

Val Gly Val Gly Cys Met Val Asp Ser Cys Gly Glu Cys Glu Asn Cys 
            100                 105                 110         

Lys Arg Gly Asp Glu Gln Tyr Cys Val Lys Gly Asn Ile Gln Thr Tyr 
        115                 120                 125             

Gly Ser Val Asp Arg Tyr Gly Gln Tyr Thr Met Gly Gly Tyr Ser Thr 
    130                 135                 140                 

His Ile Val Val Lys Glu Asp Phe Val Leu Arg Ile Pro Asp Ala Leu 
145                 150                 155                 160 

Pro Leu Asp Lys Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
                165                 170                 175     

Ser Pro Leu Arg His Trp Gln Ala Gly Pro Gly Lys Glu Val Ala Val 
            180                 185                 190         

Val Gly Leu Gly Gly Leu Gly His Met Ala Val Lys Leu Ala Lys Ala 
        195                 200                 205             

Met Gly Ala Lys Val Thr Val Leu Ser Gln Ser Leu Arg Lys Lys Glu 
    210                 215                 220                 

Asp Gly Leu Arg Leu Gly Ala Lys Ala Tyr Tyr Ala Thr Ser Asp Pro 
225                 230                 235                 240 

Glu Thr Phe Arg Gln Leu Ala Gly Arg Phe Asp Leu Ile Ile Asn Thr 
                245                 250                 255     

Val Ser Ala Lys Ile Pro Ile Thr Glu Tyr Leu Gly Leu Leu Lys Thr 
            260                 265                 270         

Asp Gly Ala Leu Val Asn Val Gly Ala Pro Pro Glu Pro Leu Glu Val 
        275                 280                 285             

Asn Ala Phe Ala Leu Ile Ala Gln Arg Arg Thr Phe Ala Gly Ser Cys 
    290                 295                 300                 

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asp Phe Cys Ala Glu 
305                 310                 315                 320 

Ser Gly Val Thr Pro Glu Ile Glu Val Ile Ser Ala Asp Glu Ile Asp 
                325                 330                 335     

Ala Ala Trp Glu Arg Val Leu Lys Ser Asp Val Arg Tyr Arg Phe Val 
            340                 345                 350         

Ile Asp Ile Ser Thr Met Arg Asn 
        355                 360 

<210>   571
<211>   360
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   571
Met His Ile Cys Phe Glu Ser Ala Glu Glu Val Glu Gly Met Gln Val 
                5                   10                  15      

Lys Ala Arg Gly Val Leu Ser Lys Glu Ser Pro Phe His Ala Ile Lys 
            20                  25                  30          

Ile Glu Arg Arg Glu Leu Gln Pro Asp Asp Val Leu Ile Glu Ile His 
        35                  40                  45              

Tyr Cys Gly Ile Cys His Ser Asp Ile His Ser Ala Arg Gly Glu Trp 
    50                  55                  60                  

Gly Glu Val Arg Tyr Pro Phe Val Pro Gly His Glu Ile Thr Gly Ile 
65                  70                  75                  80  

Val Ser Lys Val Gly Ser Gln Val Thr Lys Phe Lys Pro Gly Asp Arg 
                85                  90                  95      

Val Gly Val Gly Cys Met Val Asp Ser Cys Gly Glu Cys Glu Asn Cys 
            100                 105                 110         

Lys Arg Gly Asp Glu Gln Tyr Cys Ile Lys Gly Asn Ile Gln Thr Tyr 
        115                 120                 125             

Gly Ser Val Asp Arg Tyr Gly Gln Tyr Thr Met Gly Gly Tyr Ser Thr 
    130                 135                 140                 

His Ile Val Val Lys Glu Asp Phe Val Leu Arg Ile Pro Asp Ala Leu 
145                 150                 155                 160 

Pro Leu Asp Lys Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
                165                 170                 175     

Ser Pro Leu Arg His Trp Gln Ala Gly Pro Gly Lys Glu Val Ala Val 
            180                 185                 190         

Val Gly Leu Gly Gly Leu Gly His Met Ala Val Lys Leu Ala Lys Ala 
        195                 200                 205             

Met Gly Ala Lys Val Thr Val Leu Ser Gln Ser Leu Arg Lys Lys Glu 
    210                 215                 220                 

Asp Gly Leu Arg Leu Gly Ala Lys Ala Tyr Tyr Ala Thr Ser Asp Pro 
225                 230                 235                 240 

Glu Thr Phe Arg Gln Leu Ala Gly Arg Phe Asp Leu Ile Ile Asn Thr 
                245                 250                 255     

Val Ser Ala Lys Ile Pro Ile Thr Glu Tyr Leu Gly Leu Leu Lys Thr 
            260                 265                 270         

Asp Gly Ala Leu Val Asn Val Gly Ala Pro Pro Glu Pro Leu Glu Val 
        275                 280                 285             

Asn Ala Phe Ala Leu Ile Ala Gln Arg Arg Thr Phe Ala Gly Ser Cys 
    290                 295                 300                 

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asp Phe Cys Ala Glu 
305                 310                 315                 320 

Ser Gly Val Thr Pro Glu Ile Glu Val Ile Ser Ala Asp Glu Ile Asp 
                325                 330                 335     

Ala Ala Trp Glu Arg Val Leu Lys Ser Asp Val Arg Tyr Arg Phe Val 
            340                 345                 350         

Ile Asp Ile Ser Thr Met Arg Asn 
        355                 360 

<210>   572
<211>   360
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   572
Met His Ile Cys Phe Glu Ser Ala Glu Glu Val Glu Gly Met Gln Val 
                5                   10                  15      

Lys Ala Arg Gly Val Leu Ser Lys Glu Ser Pro Phe His Ala Ile Lys 
            20                  25                  30          

Ile Glu Arg Arg Glu Leu Gln Pro Asp Asp Val Leu Ile Glu Ile His 
        35                  40                  45              

Tyr Cys Gly Ile Cys His Ser Asp Ile His Ser Ala Arg Gly Glu Trp 
    50                  55                  60                  

Gly Asp Val Arg Tyr Pro Phe Val Pro Gly His Glu Ile Thr Gly Ile 
65                  70                  75                  80  

Val Ser Lys Val Gly Ser Gln Val Thr Lys Phe Lys Pro Gly Asp Arg 
                85                  90                  95      

Val Gly Val Gly Cys Met Val Asp Ser Cys Gly Glu Cys Glu Asn Cys 
            100                 105                 110         

Lys Arg Gly Asp Glu Gln Tyr Cys Val Lys Gly Asn Ile Gln Thr Tyr 
        115                 120                 125             

Gly Ser Val Asp Arg Tyr Gly Gln Tyr Thr Met Gly Gly Tyr Ser Thr 
    130                 135                 140                 

His Ile Val Val Lys Glu Asp Phe Val Leu Arg Ile Pro Asp Ala Leu 
145                 150                 155                 160 

Pro Leu Asp Lys Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
                165                 170                 175     

Ser Pro Leu Arg His Trp Gln Ala Gly Pro Gly Lys Glu Val Ala Val 
            180                 185                 190         

Val Gly Leu Gly Gly Leu Gly His Met Ala Val Lys Leu Ala Lys Ala 
        195                 200                 205             

Met Gly Ala Lys Val Thr Val Leu Ser Gln Ser Leu Arg Lys Lys Glu 
    210                 215                 220                 

Asp Gly Leu Arg Leu Gly Ala Lys Ala Tyr Tyr Ala Thr Ser Asp Pro 
225                 230                 235                 240 

Glu Thr Phe Arg Gln Leu Ala Gly Arg Phe Asp Leu Ile Ile Asn Thr 
                245                 250                 255     

Val Ser Ala Lys Ile Pro Ile Thr Glu Tyr Leu Gly Leu Leu Lys Thr 
            260                 265                 270         

Asp Gly Ala Leu Val Asn Val Gly Ala Pro Pro Glu Pro Leu Glu Val 
        275                 280                 285             

Asn Ala Phe Ala Leu Ile Ala Gln Arg Arg Thr Phe Ala Gly Ser Cys 
    290                 295                 300                 

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asp Phe Cys Ala Glu 
305                 310                 315                 320 

Ser Gly Val Thr Pro Glu Ile Glu Val Ile Ser Ala Asp Glu Ile Asp 
                325                 330                 335     

Ala Ala Trp Glu Arg Val Leu Lys Ser Asp Val Arg Tyr Arg Phe Val 
            340                 345                 350         

Ile Asp Ile Ser Thr Met Arg Asn 
        355                 360 

<210>   573
<211>   360
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   573
Met His Ile Cys Phe Glu Ser Ala Glu Glu Val Glu Gly Met Gln Val 
                5                   10                  15      

Lys Ala Arg Gly Val Leu Ser Lys Glu Ser Pro Phe His Ala Ile Lys 
            20                  25                  30          

Ile Glu Arg Arg Glu Leu Gln Pro Asp Asp Val Leu Ile Glu Ile His 
        35                  40                  45              

Tyr Cys Gly Ile Cys His Ser Asp Ile His Ser Ala Arg Gly Glu Trp 
    50                  55                  60                  

Gly Glu Val Arg Tyr Pro Phe Val Pro Gly His Glu Ile Thr Gly Ile 
65                  70                  75                  80  

Val Ser Lys Val Gly Ser Gln Val Thr Lys Phe Lys Pro Gly Asp Arg 
                85                  90                  95      

Val Gly Val Gly Cys Met Val Asp Ser Cys Gly Glu Cys Glu Asn Cys 
            100                 105                 110         

Lys Arg Gly Asp Glu Gln Tyr Cys Val Lys Gly Asn Ile Gln Thr Tyr 
        115                 120                 125             

Gly Ser Val Asp Arg Tyr Gly Gln Tyr Thr Met Gly Gly Tyr Ser Thr 
    130                 135                 140                 

His Ile Val Val Lys Glu Asp Phe Val Leu Arg Ile Pro Asp Ala Leu 
145                 150                 155                 160 

Pro Leu Asp Lys Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Thr Tyr 
                165                 170                 175     

Ser Pro Leu Arg His Trp Gln Ala Gly Pro Gly Lys Glu Val Ala Val 
            180                 185                 190         

Val Gly Leu Gly Gly Leu Gly His Met Ala Val Lys Leu Ala Lys Ala 
        195                 200                 205             

Met Gly Ala Lys Val Thr Val Leu Ser Gln Ser Leu Arg Lys Lys Glu 
    210                 215                 220                 

Asp Gly Leu Arg Leu Gly Ala Lys Ala Tyr Tyr Ala Thr Ser Asp Pro 
225                 230                 235                 240 

Glu Thr Phe Arg Gln Leu Ala Gly Arg Phe Asp Leu Ile Ile Asn Thr 
                245                 250                 255     

Val Ser Ala Lys Ile Pro Ile Thr Glu Tyr Leu Gly Leu Leu Lys Thr 
            260                 265                 270         

Asp Gly Ala Leu Val Asn Val Gly Ala Pro Pro Glu Pro Leu Glu Val 
        275                 280                 285             

Asn Ala Phe Ala Leu Ile Ala Gln Arg Arg Thr Phe Ala Gly Ser Cys 
    290                 295                 300                 

Ile Gly Gly Ile Arg Glu Thr Gln Glu Met Leu Asp Phe Cys Ala Glu 
305                 310                 315                 320 

Ser Gly Val Thr Pro Glu Ile Glu Val Ile Ser Ala Asp Glu Ile Asp 
                325                 330                 335     

Ala Ala Trp Glu Arg Val Leu Lys Ser Asp Val Arg Tyr Arg Phe Val 
            340                 345                 350         

Ile Asp Leu Ser Thr Met Arg Asn 
        355                 360 

<210>   574
<211>   1083
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   574
ttgcacatct gtttcgaatc ggcagaggag gtcgaaggga tgcaggtcaa ggctcgcggc       60

gtgttgagca aggagagccc gtttcatgcc ttaaagatcg agcggcggga gcttcagccc      120

gacgatgtgc tgattgaaat ccactactgc ggcatctgcc actccgacat ccactcggcc      180

cgcggcgagt ggggcgaggt gcggtatcca ttcgtgcccg ggcatgagat caccggcatc      240

gtctcgaagg tcggcagcca ggtgaccaag ttcaagccgg gcgatcgcgt cggcgtggga      300

tgcatggtcg actcgtgcgg cgaatgcgag aactgtaagc gcggcgacga gcagtactgc      360

gtgaagggca acatccagac gtacggcagt gtcgaccgct acgggcagta caccatgggc      420

ggctactcca cgcacatcgt ggtgaaggag gacttcgtcc tccgcatccc ggatgcgctg      480

cctctggaca aggcggcgcc gcttctgtgc gcgggcatca cgacgtactc gccgcttcgc      540

cactggcagg cgggcccggg aaaggaggtc gccgtcgtcg gcctcggggg gctcggtcac      600

atggccgtga agctcgcgaa ggcgatgggg gcgaaggtca ccgtgctctc ccagtccctg      660

cggaaaaagg aggacggcct gcgcctcggc gcgaaagcct actacgcgac gagcgatccc      720

gagacattcc gccagctcgc cggacgcttc gatctcatca tcaacacggt gtcggcgaag      780

atccccatca ctgagtatct gggccttctg aagacggatg gcgctctggt caacgtcggc      840

gcgccgccgg agccgctcga ggtgaacgcg tttgcgctca tcgcacagcg ccgcacgttt      900

gcgggctcct gcatcggcgg catccgcgag acgcaggaga tgctcgattt ctgcgctgag      960

agcggtgtga cgcccgagat cgaggtcatc tcggcggacg agatcgacgc ggcgtgggag     1020

cgggtgctga agtcggacgt gcggtatcga ttcgtgatcg acatcagcac gatgcgcaat     1080

tga                                                                   1083


<210>   575
<211>   1083
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   575
ttgcacatct gtttcgaatc ggcagaggag gtcgaaggga tgcagattaa ggctcgcggc       60

gtgttgagca aggagagccc gtttcatgcc atcaagatcg agcggcggga gcttcagccc      120

gacgatgtgc tgattgaaat ccactactgc ggcatctgcc actccgacat ccactcggcc      180

cgcggcgagt ggggcgaggt gcggtatcca ttcgtgcccg ggcatgagat caccggcatc      240

gtctcgaagg tcggcagcca ggtgaccaag ttcaagccgg gcgatcgcgt cggcgtggga      300

tgcatggtcg actcgtgcgg cgaatgcgag aactgtaagc gcggcgacga gcagtactgc      360

gtgaagggca acatccagac gtacggcagt gtcgaccgct acgggcagta caccatgggc      420

ggctactcca cgcacatcgt ggtgaaggag gacttcgtcc tccgcatccc ggatgcgctg      480

cctctggaca aggcggcgcc gcttctgtgc gcgggcatca cgacgtactc gccgcttcgc      540

cactggcagg cgggcccggg aaaggaggtc gccgtcgtcg gcctcggggg gctcggtcac      600

atggccgtga agctcgcgaa ggcgatgggg gcgaaggtca ccgtgctctc ccagtccctg      660

cggaaaaagg aggacggcct gcgcctcggc gcgaaagcct actacgcgac gagcgatccc      720

gagacattcc gccagctcgc cggacgcttc gatctcatca tcaacacggt gtcggcgaag      780

atccccatca ctgagtatct gggccttctg aagacggatg gcgctctggt caacgtcggc      840

gcgccgccgg agccgctcga ggtgaacgcg tttgcgctca tcgcacagcg ccgcacgttt      900

gcgggctcct gcatcggcgg catccgcgag acgcaggaga tgctcgattt ctgcgctgag      960

agcggtgtga cgcccgagat cgaggtcatc tcggcggacg agatcgacgc ggcgtgggag     1020

cgggtgctga agtcggacgt gcggtatcga ttcgtgatcg acatcagcac gatgcgcaat     1080

tga                                                                   1083


<210>   576
<211>   1083
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   576
ttgcacatct gtttcgaatc ggcagaggag gtcgaaggga tgcaggtcaa ggctcgcggc       60

gtgttgagca aggagagccc gtttcatgcc atcaagatcg agcggcggga gcttcagccc      120

gacgatgtgc tgattgaaat ccactactgc ggcatctgcc actccgacat ccactcggcc      180

cgcggcgagt ggggcgaggt gcggtatcca ttcgtgcccg ggcatgagat caccggcatc      240

gtctcgaagg tcggcagcca ggtgaccaag ttcaagccgg gcgatcgcgt cggcgtggga      300

tgcatggtcg actcgtgcgg cgaatgcgag aactgtaagc gcggcgacga gcagtactgc      360

attaagggca acatccagac gtacggcagt gtcgaccgct acgggcagta caccatgggc      420

ggctactcca cgcacatcgt ggtgaaggag gacttcgtcc tccgcatccc ggatgcgctg      480

cctctggaca aggcggcgcc gcttctgtgc gcgggcatca cgacgtactc gccgcttcgc      540

cactggcagg cgggcccggg aaaggaggtc gccgtcgtcg gcctcggggg gctcggtcac      600

atggccgtga agctcgcgaa ggcgatgggg gcgaaggtca ccgtgctctc ccagtccctg      660

cggaaaaagg aggacggcct gcgcctcggc gcgaaagcct actacgcgac gagcgatccc      720

gagacattcc gccagctcgc cggacgcttc gatctcatca tcaacacggt gtcggcgaag      780

atccccatca ctgagtatct gggccttctg aagacggatg gcgctctggt caacgtcggc      840

gcgccgccgg agccgctcga ggtgaacgcg tttgcgctca tcgcacagcg ccgcacgttt      900

gcgggctcct gcatcggcgg catccgcgag acgcaggaga tgctcgattt ctgcgctgag      960

agcggtgtga cgcccgagat cgaggtcatc tcggcggacg agatcgacgc ggcgtgggag     1020

cgggtgctga agtcggacgt gcggtatcga ttcgtgatcg acatcagcac gatgcgcaat     1080

tga                                                                   1083


<210>   577
<211>   1083
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   577
ttgcacatct gtttcgaatc ggcagaggag gtcgaaggga tgcaggtcaa ggctcgcggc       60

gtgttgagca aggagagccc gtttcatgcc atcaagatcg agcggcggga gcttcagccc      120

gacgatgtgc tgattgaaat ccactactgc ggcatctgcc actccgacat ccactcggcc      180

cgcggcgagt ggggcgatgt gcggtatcca ttcgtgcccg ggcatgagat caccggcatc      240

gtctcgaagg tcggcagcca ggtgaccaag ttcaagccgg gcgatcgcgt cggcgtggga      300

tgcatggtcg actcgtgcgg cgaatgcgag aactgtaagc gcggcgacga gcagtactgc      360

gtgaagggca acatccagac gtacggcagt gtcgaccgct acgggcagta caccatgggc      420

ggctactcca cgcacatcgt ggtgaaggag gacttcgtcc tccgcatccc ggatgcgctg      480

cctctggaca aggcggcgcc gcttctgtgc gcgggcatca cgacgtactc gccgcttcgc      540

cactggcagg cgggcccggg aaaggaggtc gccgtcgtcg gcctcggggg gctcggtcac      600

atggccgtga agctcgcgaa ggcgatgggg gcgaaggtca ccgtgctctc ccagtccctg      660

cggaaaaagg aggacggcct gcgcctcggc gcgaaagcct actacgcgac gagcgatccc      720

gagacattcc gccagctcgc cggacgcttc gatctcatca tcaacacggt gtcggcgaag      780

atccccatca ctgagtatct gggccttctg aagacggatg gcgctctggt caacgtcggc      840

gcgccgccgg agccgctcga ggtgaacgcg tttgcgctca tcgcacagcg ccgcacgttt      900

gcgggctcct gcatcggcgg catccgcgag acgcaggaga tgctcgattt ctgcgctgag      960

agcggtgtga cgcccgagat cgaggtcatc tcggcggacg agatcgacgc ggcgtgggag     1020

cgggtgctga agtcggacgt gcggtatcga ttcgtgatcg acatcagcac gatgcgcaat     1080

tga                                                                   1083


<210>   578
<211>   1083
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   578
ttgcacatct gtttcgaatc ggcagaggag gtcgaaggga tgcaggtcaa ggctcgcggc       60

gtgttgagca aggagagccc gtttcatgcc atcaagatcg agcggcggga gcttcagccc      120

gacgatgtgc tgattgaaat ccactactgc ggcatctgcc actccgacat ccactcggcc      180

cgcggcgagt ggggcgaggt gcggtatcca ttcgtgcccg ggcatgagat caccggcatc      240

gtctcgaagg tcggcagcca ggtgaccaag ttcaagccgg gcgatcgcgt cggcgtggga      300

tgcatggtcg actcgtgcgg cgaatgcgag aactgtaagc gcggcgacga gcagtactgc      360

gtgaagggca acatccagac gtacggcagt gtcgaccgct acgggcagta caccatgggc      420

ggctactcca cgcacatcgt ggtgaaggag gacttcgtcc tccgcatccc ggatgcgctg      480

cctctggaca aggcggcgcc gcttctgtgc gcgggcatca cgacgtactc gccgcttcgc      540

cactggcagg cgggcccggg aaaggaggtc gccgtcgtcg gcctcggggg gctcggtcac      600

atggccgtga agctcgcgaa ggcgatgggg gcgaaggtca ccgtgctctc ccagtccctg      660

cggaaaaagg aggacggcct gcgcctcggc gcgaaagcct actacgcgac gagcgatccc      720

gagacattcc gccagctcgc cggacgcttc gatctcatca tcaacacggt gtcggcgaag      780

atccccatca ctgagtatct gggccttctg aagacggatg gcgctctggt caacgtcggc      840

gcgccgccgg agccgctcga ggtgaacgcg tttgcgctca tcgcacagcg ccgcacgttt      900

gcgggctcct gcatcggcgg catccgcgag acgcaggaga tgctcgattt ctgcgctgag      960

agcggtgtga cgcccgagat cgaggtcatc tcggcggacg agatcgacgc ggcgtgggag     1020

cgggtgctga agtcggacgt gcggtatcga ttcgtgatcg acttaagcac gatgcgcaat     1080

tga                                                                   1083


<210>   579
<211>   357
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   579
Met Glu Arg Glu Arg Gly Gln Ala Val Lys Ala Ala Arg Met Val Gly 
                5                   10                  15      

Phe Arg Glu Pro Leu Val Ile Glu Arg Val Pro Asp Pro Thr Pro Gly 
            20                  25                  30          

Pro Glu Asp Ala Val Ile Arg Val Glu Ala Ser Gly Ile Cys Arg Ser 
        35                  40                  45              

Asp Trp His Gly Trp Met Gly Asp Trp Thr Trp Leu Gly Leu Ser Pro 
    50                  55                  60                  

Gln Leu Pro Ile Thr Pro Gly His Glu Phe Gly Gly Glu Ile Val Ala 
65                  70                  75                  80  

Leu Gly Arg Glu Val Arg Asp Phe Gln Ile Gly Asp Lys Val Thr Val 
                85                  90                  95      

Pro Phe His Tyr Ala Cys Gly His Cys Glu His Cys His Ala Gly Val 
            100                 105                 110         

Pro Asn Arg Cys Asp His Val Gly Ile Tyr Gly Phe Ser Trp Asp Gly 
        115                 120                 125             

Ser Phe Ala Glu Tyr Val Val Val Arg Asn Ala Asn Met Asn Leu Ile 
    130                 135                 140                 

Arg Leu Pro Glu Gly Val Asp Ala Leu Thr Ala Ala Ala Val Gly Cys 
145                 150                 155                 160 

Arg Phe Met Thr Gly Tyr His Gly Val Met Arg Gly Gly Val Arg Pro 
                165                 170                 175     

Gly Gln Trp Val Ala Val His Gly Ala Gly Gly Val Gly Leu Ser Ala 
            180                 185                 190         

Ile Gln Thr Ala Tyr Ala Val Gly Ala Arg Val Ile Ala Val Asp Val 
        195                 200                 205             

Asp Asp Glu Lys Leu Ala Lys Ala Arg Glu Glu Gly Ala Cys Glu Val 
    210                 215                 220                 

Val Asn Ala Lys Asn Gln Pro Val Val Glu Ala Ile Arg Glu Ile Thr 
225                 230                 235                 240 

Lys Gly Gly Ala His Val Ser Ile Asp Ala Leu Gly Ile Arg Asp Thr 
                245                 250                 255     

Val Leu Asn Ser Val Leu Ser Leu Arg Lys Gly Gly Arg His Val Gln 
            260                 265                 270         

Ile Gly Leu Thr Thr Ser Gln Glu Gly Gly Phe Val Pro Leu Pro Met 
        275                 280                 285             

Asp Leu Ile Thr Ser Cys Glu Ile Glu Val Val Gly Ser Leu Gly Ile 
    290                 295                 300                 

Pro His Pro Asp Tyr Ala Gly Leu Leu Ala Leu Val Ala Glu Gly Arg 
305                 310                 315                 320 

Leu Arg Pro Arg Asn Leu Val Glu Arg Glu Val Arg Leu Glu Asp Val 
                325                 330                 335     

Asn Glu Val Phe Asp Lys Met Thr Arg Phe Glu Thr Arg Gly Phe Asn 
            340                 345                 350         

Met Ile Thr Ala Phe 
        355         

<210>   580
<211>   1074
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   580
gtggaaaggg agcgtggaca agccgtgaaa gcagcgagaa tggtgggatt tcgcgagccg       60

ctcgtcatcg agcgcgtgcc ggatccgaca cccgggccgg aggacgccgt gatccgggtg      120

gaggcgagcg gcatctgtcg gagcgactgg catggatgga tgggggactg gacctggctc      180

gggctttcgc cgcagttgcc catcaccccc ggtcacgaat tcggtggcga gatcgtcgca      240

ttggggcggg aggtgcgaga ctttcaaatc ggcgacaagg tgacggtgcc gtttcactac      300

gcctgcggac actgtgaaca ctgccacgcg ggcgtgccga accggtgtga tcacgtcggc      360

atctacggct tcagttggga cggcagcttc gcggaatatg tggtcgttcg aaacgcgaat      420

atgaacctga ttcgcctgcc ggaaggcgtc gacgccctta cggcagccgc cgtagggtgc      480

cggtttatga ccgggtatca cggcgtgatg cggggaggcg tgaggcccgg acagtgggtg      540

gcggtgcacg gcgcaggtgg cgtgggcctc tcggccattc agacggcgta cgccgtgggc      600

gcgcgcgtga ttgcggtcga tgtggacgac gagaagctgg ccaaagcgcg cgaggaaggc      660

gcgtgtgagg ttgtgaacgc aaaaaaccag cccgtggtgg aggccatccg ggagatcacc      720

aagggcgggg cccacgtgag catcgatgcg ttgggcattc gggacacggt cctgaactcc      780

gtattgagcc ttcgcaaggg aggcaggcac gtgcagattg gtctcaccac gtcccaagag      840

ggtgggtttg tgccgcttcc catggatctc atcacgagtt gcgagattga ggtcgtgggg      900

agcctcggca ttccgcaccc ggactacgcg gggctcctcg cgttggttgc cgaaggtcgc      960

ctgaggccga gaaacctggt ggagcgagag gtccgactcg aagatgtcaa cgaggtgttc     1020

gacaaaatga cgcggtttga aaccagaggt ttcaacatga tcacggcgtt ctga           1074


<210>   581
<211>   351
<212>   PRT
<213>   Streptomyces refuineus subsp. thermotolerans

<400>   581
Val Arg Ala Ala Gln Ile Val Gly Tyr Gly Glu Pro Leu Gln Val Arg 
                5                   10                  15      

Glu Val Pro Asp Pro Ala Pro Glu Pro Gly Gly Val Val Val Ala Val 
            20                  25                  30          

Leu Ala Thr Gly Ile Cys Arg Ser Asp Trp His Gly Trp Arg Gly Asp 
        35                  40                  45              

Trp Glu Trp Leu Gly Gly Arg Ile Ala Leu Pro Arg Thr Pro Gly His 
    50                  55                  60                  

Glu Ile Ala Gly Glu Val Val Ala Ala Gly Pro Gly Val Arg Gly Val 
65                  70                  75                  80  

Arg Val Gly Asp Arg Val Thr Val Pro Phe His Leu Ala Cys Gly Thr 
                85                  90                  95      

Cys Ala His Cys Arg Ala Gly Gln Ala Asn Leu Cys Asp Glu Met Glu 
            100                 105                 110         

Val Leu Gly Phe Trp Arg Asp Gly Gly Tyr Ala Glu Tyr Val Arg Ile 
        115                 120                 125             

Pro His Ala Asp Phe Asn Cys Val Arg Ile Pro Asp Gly Val Thr Pro 
    130                 135                 140                 

Leu Thr Ala Ser Ala Ile Gly Cys Arg Phe Met Thr Ala Phe His Ala 
145                 150                 155                 160 

Val Asp Gly Gln Gly Arg Val Arg Pro Gly Glu Trp Val Ala Val His 
                165                 170                 175     

Gly Val Gly Gly Val Gly Leu Ser Cys Val Gln Ile Ala Ser Ala Ala 
            180                 185                 190         

Gly Ala Ser Val Val Ala Val Asp Ile Asp Pro Ala Lys Leu Ala Leu 
        195                 200                 205             

Ala Glu Gln Gln Gly Ala Ala His Thr Val Asp Ala Gly Ala Glu Gln 
    210                 215                 220                 

Asp Val Pro Ala Ala Val Arg Glu Val Thr Gly Gly Gly Ala His Val 
225                 230                 235                 240 

Ser Ile Asp Ala Leu Gly Ile Arg Thr Thr Val Val Asn Ser Val Arg 
                245                 250                 255     

Ser Leu Arg Lys Arg Gly Arg His Val Gln Val Gly Leu Thr Gly Ala 
            260                 265                 270         

Glu Asp Ala Gly Glu Ile Ala Leu Pro Ile Asp Leu Ile Thr Leu Gly 
        275                 280                 285             

Glu Leu Thr Val Val Gly Ser His Gly Asn Pro His Ala Ala Tyr Pro 
    290                 295                 300                 

Arg Leu Leu Ser Leu Ile Glu Ser Gly Arg Leu Ala Pro Gln Thr Leu 
305                 310                 315                 320 

Val Gln Arg Thr Val Ser Leu Asp Gln Ala Gly Asp Val Leu Ala Ala 
                325                 330                 335     

Met Asp Ala Phe Ala Thr Ser Gly Leu Thr Val Ile Asp Arg Phe 
            340                 345                 350     

<210>   582
<211>   349
<212>   PRT
<213>   Propionibacterium acnes KPA171202

<400>   582
Met Lys Ala Ala Leu Val Glu Gln Tyr His Glu Pro Leu Ala Ile Arg 
                5                   10                  15      

Asp Ile Pro Glu Pro Ala His Asp Ser Asp Gly Val Val Val Glu Val 
            20                  25                  30          

Lys Ala Cys Gly Val Cys Arg Ser Asp Trp His Gly Trp Gln Gly Glu 
        35                  40                  45              

Trp Pro Gly Phe Thr Gly Gly Ser Leu Pro His Ile Phe Gly His Glu 
    50                  55                  60                  

Phe Val Gly Leu Val Ser Asp Ile Gly Asn Asn Val Ser Arg Tyr Arg 
65                  70                  75                  80  

Val Gly Asp Arg Val Ile Val Pro Phe Thr Leu Gly Cys Gly His Cys 
                85                  90                  95      

Glu Tyr Cys Arg Ser Gly His Ser Asn Val Cys Pro Thr Val Ser Met 
            100                 105                 110         

Pro Gly Phe Ser Tyr Asp Gly Gly Phe Ala Gln Tyr Val Thr Val Pro 
        115                 120                 125             

Asp Ala Asp Ala Asn Leu Val Lys Leu Pro Asp Ala Val Asp Phe Thr 
    130                 135                 140                 

Asp Ala Ala Gly Met Gly Cys Arg Leu Met Thr Ala Tyr His Gly Ile 
145                 150                 155                 160 

Val Glu Val Gly Gln Ile His Pro Gly Asp Trp Leu Val Val Tyr Gly 
                165                 170                 175     

Ala Gly Gly Val Gly Leu Ser Ala Thr Leu Val Ala Thr Ser Ala Gly 
            180                 185                 190         

Ala Asn Val Ile Ala Val Asp Ile Ala Asp Asp Lys Leu Ala Leu Ala 
        195                 200                 205             

Arg Lys Val Gly Ala Ile Ala Thr Ile Asn Ser Arg Glu Thr Asp Pro 
    210                 215                 220                 

Val Glu Ala Val Arg Glu Leu Thr Asp Gly Gly Ala Asp Lys Ser Val 
225                 230                 235                 240 

Asp Ala Leu Gly Ile Ser Glu Thr Leu His Asn Ala Val Asn Ser Leu 
                245                 250                 255     

Arg Ser Arg Gly Thr His Ile Gln Ile Gly Met Thr Ala Glu Gly Pro 
            260                 265                 270         

Val Gly Asp Val Ala Leu Thr Ile Asn Asp Leu Ile Ala Lys Glu Ile 
        275                 280                 285             

Asp Phe Arg Gly Ser Phe Gly Met Pro Ala Val Glu Phe Arg Tyr Leu 
    290                 295                 300                 

Leu Asn Gln Val Ala Ala Gly Lys Met Lys Pro Gly Gln Leu Val Thr 
305                 310                 315                 320 

Lys Thr Ile Ala Leu Ser Glu Val Asn Asp Ala Leu Thr Ala Met Ser 
                325                 330                 335     

Thr Tyr Asn Thr Val Gly Thr Thr Val Ile Thr Asp Phe 
            340                 345                 

<210>   583
<211>   346
<212>   PRT
<213>   Silicibacter sp. TM1040

<400>   583
Met Lys Ala Val Leu Tyr Glu Thr Phe Lys Glu Leu Pro Lys Leu Val 
                5                   10                  15      

Thr Val Glu Asp Pro Thr Pro Asp Pro Asp Gly Val Val Ile Lys Val 
            20                  25                  30          

Glu Ala Thr Gly Leu Cys Arg Ser Asp Trp His Gly Trp Met Gly His 
        35                  40                  45              

Asp Ser Asp Ile Val Leu Pro His Val Pro Gly His Glu Phe Ala Gly 
    50                  55                  60                  

Val Ile Val Ala Leu Gly Lys Asn Val Arg Asn Trp Thr Val Gly Asp 
65                  70                  75                  80  

Arg Val Thr Val Pro Phe Ile Ser Gly Cys Gly Ala Cys Ser Glu Cys 
                85                  90                  95      

His Ala Gly His Gln Gln Val Cys His Asn Gln Gln Gln Pro Gly Phe 
            100                 105                 110         

Thr His Trp Gly Ser Phe Ala Glu Tyr Val Gly Val Arg Gln Ala Asp 
        115                 120                 125             

Leu Asn Leu Val Ala Leu Pro Gln Glu Met Asp Phe Ala Thr Ala Ala 
    130                 135                 140                 

Ser Leu Gly Cys Arg Phe Ala Thr Ser Phe Arg Ala Val Val Asp Gln 
145                 150                 155                 160 

Ala Gln Thr Arg Ala Gly Gln Trp Val Ala Val His Gly Cys Gly Gly 
                165                 170                 175     

Val Gly Leu Ser Ala Val Met Ile Ala Gln Ala Val Gly Ala Asn Val 
            180                 185                 190         

Ile Ala Ile Asp Ile Asp Asp Glu Lys Leu Asn Leu Ala Gln Glu Leu 
        195                 200                 205             

Gly Ala Val Ala Thr Ile Asn Gly Ala Arg Val Ala Asp Val Pro Glu 
    210                 215                 220                 

Ala Val Ile Asp Leu Ser Arg Gly Gly Ala His Val Ser Leu Asp Ala 
225                 230                 235                 240 

Leu Gly His Pro Leu Thr Cys Phe Asn Ser Ile Gln Asn Leu Arg Pro 
                245                 250                 255     

Arg Gly Lys His Val Gln Val Gly Leu Met Leu Ala Glu His Ser Thr 
            260                 265                 270         

Pro Ser Val Pro Met Ala Lys Val Ile Ala Lys Glu Leu Glu Ile Leu 
        275                 280                 285             

Gly Ser His Gly Met Gln Ala His Arg Tyr Asp Ala Met Leu Asp Met 
    290                 295                 300                 

Ile Ala Ser Gly Lys Leu Asp Pro Arg Arg Leu Val Gly Arg Glu Ile 
305                 310                 315                 320 

Ser Leu Asp Ala Ala Pro Ser Ala Leu Val Lys Met Asp Gln Phe Gln 
                325                 330                 335     

Ser Ile Gly Ala Thr Val Ile Thr Thr Phe 
            340                 345     

<210>   584
<211>   353
<212>   PRT
<213>   Haloarcula marismortui ATCC 43049

<400>   584
Met Arg Ala Ala Val Leu Glu Glu Tyr Glu Glu Pro Leu Ala Ile Arg 
                5                   10                  15      

Asp Val Glu Arg Pro Asp Pro Asp Pro Asp Gly Val Val Ala Lys Val 
            20                  25                  30          

Asp Ala Cys Gly Val Cys Arg Ser Asp Trp His Gly Trp Val Gly Asn 
        35                  40                  45              

Trp Asp Trp Phe Asp Tyr Lys Pro Pro Arg Gly His Ile Leu Gly His 
    50                  55                  60                  

Glu Pro Ser Gly Thr Val Val Glu Val Gly Glu Asn Val Asp Thr Val 
65                  70                  75                  80  

Lys Glu Gly Asp Thr Val Ala Ile Pro Phe Asn Phe Ala Cys Gly His 
                85                  90                  95      

Cys His Glu Cys Arg Val Gly Tyr Glu Asn Leu Cys Glu Asn His Leu 
            100                 105                 110         

Gly Leu Gly Phe Gln Pro Gly Ala Pro Gly Ala Phe Ala Glu Glu Val 
        115                 120                 125             

Pro Ile Pro Asn Ala Asp Ile Asn Ala Val Lys Leu Pro Asp Gly Val 
    130                 135                 140                 

Asp Pro Val Glu Val Ala Gly Met Gly Cys Arg Phe Met Thr Ser Tyr 
145                 150                 155                 160 

Arg Gly Met Ala His Gln Ala Asp Val Ser Arg Gly Glu Tyr Val Val 
                165                 170                 175     

Val Gln Gly Leu Gly Gly Ile Gly Leu Ser Ala Val His Ile Ala Asp 
            180                 185                 190         

Ala Leu Gly Gly Asn Val Ile Gly Val Asp Leu Met Asp Glu Lys Leu 
        195                 200                 205             

Glu Met Ala Glu Glu Leu Gly Ala Ile Asp Thr Val Asn Ala Ala Glu 
    210                 215                 220                 

Glu Asp Asp Val Val Gln Ala Val Arg Asp Ile Thr Asp Gly Gly Ala 
225                 230                 235                 240 

His Val Ser Leu Asp Ala Leu Gly Ile Glu Glu Thr Cys Gln Asn Ala 
                245                 250                 255     

Ile Glu Ser Leu Arg Thr Arg Gly Arg His Val Gln Ile Gly Leu Thr 
            260                 265                 270         

Thr Lys Glu Gln Arg Gly Tyr Asn Ser Leu Pro Thr Asp Thr Ile Val 
        275                 280                 285             

Met Asn Glu Ile Gln Val Gln Gly Ser Ser Gly Leu Pro Pro Ser Lys 
    290                 295                 300                 

Tyr Gly Glu Met Phe Arg Met Val Glu Asn Gly Lys Leu Asp Pro Gly 
305                 310                 315                 320 

Ala Val Ile Thr Asp Lys Ile Gly Leu Glu Gly Val Ser Asp Glu Leu 
                325                 330                 335     

Ala Ala Met Thr Asp Tyr Glu Thr Ile Gly Ile Pro Val Val Asn Glu 
            340                 345                 350         

Phe 
    

<210>   585
<211>   345
<212>   PRT
<213>   Roseovarius sp. HTCC2601

<400>   585
Met Lys Ala Val Leu Phe Glu Thr Phe Gln Glu Ala Pro Lys Leu Val 
                5                   10                  15      

Thr Val Pro Asp Pro Val Pro Asp Ala His Gly Val Val Leu Lys Val 
            20                  25                  30          

Ala Ala Thr Gly Val Cys Arg Ser Asp Trp His Gly Trp Met Gly His 
        35                  40                  45              

Asp Ser Asp Ile Glu Leu Pro His Val Pro Gly His Glu Leu Ala Gly 
    50                  55                  60                  

Glu Val Ala Ala Val Gly Lys Asp Val Arg Asn Trp Lys Ile Gly Asp 
65                  70                  75                  80  

Lys Val Thr Val Pro Phe Ile Cys Gly Cys Gly Ser Cys Ser Glu Cys 
                85                  90                  95      

His Ala Gly Gln Gln Gln Val Cys Leu His Gln Glu Gln Pro Gly Phe 
            100                 105                 110         

Thr His Trp Gly Ser Phe Ala Glu Tyr Val Pro Ile His Gln Ala Asp 
        115                 120                 125             

Leu Asn Leu Val Ala Leu Pro Glu Gly Met Gly Phe Asp Thr Ala Ala 
    130                 135                 140                 

Ser Leu Gly Cys Arg Phe Ala Thr Ser Phe Arg Ala Val Ile Asp Gln 
145                 150                 155                 160 

Gly Lys Val Arg Ala Gly Gln Trp Val Ala Val His Gly Cys Gly Gly 
                165                 170                 175     

Val Gly Leu Ser Ala Val Met Ile Ala Ala Ala Ala Gly Ala Asn Val 
            180                 185                 190         

Ile Gly Val Asp Leu Asp Pro Val Lys Leu Ala Leu Ala Lys Glu Ile 
        195                 200                 205             

Gly Ala Val Ala Ala Ile Asp Gly His Glu Ala Asp Val Pro Gly Ala 
    210                 215                 220                 

Ile Arg Glu Ile Thr Arg Gly Gly Ala His Val Ser Leu Asp Ala Leu 
225                 230                 235                 240 

Gly His Pro Val Thr Met Thr Asn Ser Ile Leu Cys Leu Arg Pro Arg 
                245                 250                 255     

Gly Lys His Val Gln Val Gly Leu Met Leu Gly Glu His Ala Ala Pro 
            260                 265                 270         

Gln Val Pro Met Pro Lys Ile Val Gly Gln Glu Ile Glu Leu Leu Gly 
        275                 280                 285             

Ser His Gly Met Gln Ala His Arg Tyr Gly Ala Met Leu Asp Met Val 
    290                 295                 300                 

Ala Ser Gly Lys Leu Asp Pro Ala Arg Leu Val Gly Glu Arg Ile Ser 
305                 310                 315                 320 

Leu Ala Glu Ala Pro Ala Ala Leu Met Ala Met Asp Ser Phe Arg Ser 
                325                 330                 335     

Val Gly Ala Thr Val Ile Thr Arg Phe 
            340                 345 

<210>   586
<211>   357
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   586
Met Glu Arg Glu Arg Gly Gln Ala Val Lys Ala Ala Arg Met Val Gly 
                5                   10                  15      

Phe Arg Glu Pro Leu Val Ile Glu Arg Val Pro Asp Pro Thr Pro Gly 
            20                  25                  30          

Pro Glu Asp Ala Val Ile Arg Val Glu Ala Ser Gly Ile Cys Arg Ser 
        35                  40                  45              

Asp Trp His Gly Trp Met Gly Asp Trp Thr Trp Leu Gly Leu Ser Pro 
    50                  55                  60                  

Gln Leu Pro Ile Thr Pro Gly His Glu Phe Gly Gly Glu Ile Val Ala 
65                  70                  75                  80  

Leu Gly Arg Glu Val Arg Asp Phe Gln Leu Gly Asp Lys Val Thr Val 
                85                  90                  95      

Pro Phe His Tyr Ala Cys Gly His Cys Glu His Cys His Ala Gly Val 
            100                 105                 110         

Pro Asn Arg Cys Asp His Val Gly Ile Tyr Gly Phe Ser Trp Asp Gly 
        115                 120                 125             

Ser Phe Ala Glu Tyr Val Val Val Arg Asn Ala Asn Met Asn Leu Ile 
    130                 135                 140                 

Arg Leu Pro Glu Gly Val Asp Ala Leu Thr Ala Ala Ala Val Gly Cys 
145                 150                 155                 160 

Arg Phe Met Thr Gly Tyr His Gly Val Met Arg Gly Gly Val Arg Pro 
                165                 170                 175     

Gly Gln Trp Val Ala Val His Gly Ala Gly Gly Val Gly Leu Ser Ala 
            180                 185                 190         

Ile Gln Thr Ala Tyr Ala Val Gly Ala Arg Val Ile Ala Val Asp Val 
        195                 200                 205             

Asp Asp Glu Lys Leu Ala Lys Ala Arg Glu Glu Gly Ala Cys Glu Val 
    210                 215                 220                 

Val Asn Ala Lys Asn Gln Pro Val Val Glu Ala Ile Arg Glu Ile Thr 
225                 230                 235                 240 

Lys Gly Gly Ala His Val Ser Ile Asp Ala Leu Gly Ile Arg Asp Thr 
                245                 250                 255     

Val Leu Asn Ser Val Leu Ser Leu Arg Lys Gly Gly Arg His Val Gln 
            260                 265                 270         

Ile Gly Leu Thr Thr Ser Gln Glu Gly Gly Phe Val Pro Leu Pro Met 
        275                 280                 285             

Asp Leu Ile Thr Ser Cys Glu Ile Glu Val Val Gly Ser Leu Gly Ile 
    290                 295                 300                 

Pro His Pro Asp Tyr Ala Gly Leu Leu Ala Leu Val Ala Glu Gly Arg 
305                 310                 315                 320 

Leu Arg Pro Arg Asn Leu Val Glu Arg Glu Val Arg Leu Glu Asp Val 
                325                 330                 335     

Asn Glu Val Phe Asp Lys Met Thr Arg Phe Glu Thr Arg Gly Phe Asn 
            340                 345                 350         

Met Ile Thr Ala Phe 
        355         

<210>   587
<211>   357
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   587
Met Glu Arg Glu Arg Gly Gln Ala Val Lys Ala Ala Arg Met Val Gly 
                5                   10                  15      

Phe Arg Glu Pro Leu Val Ile Glu Arg Val Pro Asp Pro Thr Pro Gly 
            20                  25                  30          

Pro Glu Asp Ala Val Ile Arg Val Glu Ala Ser Gly Ile Cys Arg Ser 
        35                  40                  45              

Asp Trp His Gly Trp Met Gly Asp Trp Thr Trp Leu Gly Leu Ser Pro 
    50                  55                  60                  

Gln Leu Pro Ile Thr Pro Gly His Glu Phe Gly Gly Glu Ile Val Ala 
65                  70                  75                  80  

Leu Gly Arg Glu Val Arg Asp Phe Gln Ile Gly Asp Lys Val Thr Val 
                85                  90                  95      

Pro Phe His Tyr Ala Cys Gly His Cys Glu His Cys His Ala Gly Val 
            100                 105                 110         

Pro Asn Arg Cys Asp His Val Gly Ile Tyr Gly Phe Ser Trp Asp Gly 
        115                 120                 125             

Ser Phe Ala Glu Tyr Val Val Val Arg Asn Ala Asn Met Asn Leu Ile 
    130                 135                 140                 

Arg Leu Pro Glu Gly Val Asp Ala Leu Thr Ala Ala Ala Val Gly Cys 
145                 150                 155                 160 

Arg Phe Met Thr Gly Tyr His Gly Val Met Arg Gly Gly Val Arg Pro 
                165                 170                 175     

Gly Gln Trp Val Ala Val His Gly Ala Gly Gly Val Gly Leu Ser Ala 
            180                 185                 190         

Ile Gln Thr Ala Tyr Ala Val Gly Ala Arg Val Ile Ala Val Asp Val 
        195                 200                 205             

Asp Asp Glu Lys Leu Ala Lys Ala Arg Glu Glu Gly Ala Cys Glu Val 
    210                 215                 220                 

Val Asn Ala Lys Asn Gln Pro Val Val Glu Ala Ile Arg Glu Ile Thr 
225                 230                 235                 240 

Lys Gly Gly Ala His Val Ser Ile Asp Ala Leu Gly Ile Arg Asp Thr 
                245                 250                 255     

Val Leu Asn Ser Val Leu Ser Leu Arg Lys Gly Gly Arg His Val Gln 
            260                 265                 270         

Ile Gly Leu Thr Thr Ser Gln Asp Gly Gly Phe Val Pro Leu Pro Met 
        275                 280                 285             

Asp Leu Ile Thr Ser Cys Glu Ile Glu Val Val Gly Ser Leu Gly Ile 
    290                 295                 300                 

Pro His Pro Asp Tyr Ala Gly Leu Leu Ala Leu Val Ala Glu Gly Arg 
305                 310                 315                 320 

Leu Arg Pro Arg Asn Leu Val Glu Arg Glu Val Arg Leu Glu Asp Val 
                325                 330                 335     

Asn Glu Val Phe Asp Lys Met Thr Arg Phe Glu Thr Arg Gly Phe Asn 
            340                 345                 350         

Met Ile Thr Ala Phe 
        355         

<210>   588
<211>   357
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   588
Met Glu Arg Glu Arg Gly Gln Ala Val Lys Ala Ala Arg Met Val Gly 
                5                   10                  15      

Phe Arg Glu Pro Leu Val Ile Glu Arg Val Pro Asp Pro Thr Pro Gly 
            20                  25                  30          

Pro Glu Asp Ala Val Ile Arg Val Glu Ala Ser Gly Ile Cys Arg Ser 
        35                  40                  45              

Asp Trp His Gly Trp Met Gly Asp Trp Thr Trp Leu Gly Leu Ser Pro 
    50                  55                  60                  

Gln Ile Pro Ile Thr Pro Gly His Glu Phe Gly Gly Glu Ile Val Ala 
65                  70                  75                  80  

Leu Gly Arg Glu Val Arg Asp Phe Gln Ile Gly Asp Lys Val Thr Val 
                85                  90                  95      

Pro Phe His Tyr Ala Cys Gly His Cys Glu His Cys His Ala Gly Val 
            100                 105                 110         

Pro Asn Arg Cys Asp His Val Gly Ile Tyr Gly Phe Ser Trp Asp Gly 
        115                 120                 125             

Ser Phe Ala Glu Tyr Val Val Val Arg Asn Ala Asn Met Asn Leu Ile 
    130                 135                 140                 

Arg Leu Pro Glu Gly Val Asp Ala Leu Thr Ala Ala Ala Val Gly Cys 
145                 150                 155                 160 

Arg Phe Met Thr Gly Tyr His Gly Val Met Arg Gly Gly Val Arg Pro 
                165                 170                 175     

Gly Gln Trp Val Ala Val His Gly Ala Gly Gly Val Gly Leu Ser Ala 
            180                 185                 190         

Ile Gln Thr Ala Tyr Ala Val Gly Ala Arg Val Ile Ala Val Asp Val 
        195                 200                 205             

Asp Asp Glu Lys Leu Ala Lys Ala Arg Glu Glu Gly Ala Cys Glu Val 
    210                 215                 220                 

Val Asn Ala Lys Asn Gln Pro Val Val Glu Ala Ile Arg Glu Ile Thr 
225                 230                 235                 240 

Lys Gly Gly Ala His Val Ser Ile Asp Ala Leu Gly Ile Arg Asp Thr 
                245                 250                 255     

Val Leu Asn Ser Val Leu Ser Leu Arg Lys Gly Gly Arg His Val Gln 
            260                 265                 270         

Ile Gly Leu Thr Thr Ser Gln Glu Gly Gly Phe Val Pro Leu Pro Met 
        275                 280                 285             

Asp Leu Ile Thr Ser Cys Glu Ile Glu Val Val Gly Ser Leu Gly Ile 
    290                 295                 300                 

Pro His Pro Asp Tyr Ala Gly Leu Leu Ala Leu Val Ala Glu Gly Arg 
305                 310                 315                 320 

Leu Arg Pro Arg Asn Leu Val Glu Arg Glu Val Arg Leu Glu Asp Val 
                325                 330                 335     

Asn Glu Val Phe Asp Lys Met Thr Arg Phe Glu Thr Arg Gly Phe Asn 
            340                 345                 350         

Met Ile Thr Ala Phe 
        355         

<210>   589
<211>   357
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   589
Met Glu Arg Glu Arg Gly Gln Ala Val Lys Ala Ala Arg Met Val Gly 
                5                   10                  15      

Phe Arg Glu Pro Leu Val Ile Glu Arg Val Pro Asp Pro Thr Pro Gly 
            20                  25                  30          

Pro Glu Asp Ala Val Ile Arg Val Glu Ala Ser Gly Ile Cys Arg Ser 
        35                  40                  45              

Asp Trp His Gly Trp Met Gly Asp Trp Thr Trp Leu Gly Leu Ser Pro 
    50                  55                  60                  

Gln Leu Pro Ile Thr Pro Gly His Glu Phe Gly Gly Glu Ile Val Ala 
65                  70                  75                  80  

Leu Gly Arg Glu Val Arg Asp Phe Gln Ile Gly Asp Lys Val Thr Val 
                85                  90                  95      

Pro Phe His Tyr Ala Cys Gly His Cys Glu His Cys His Ala Gly Val 
            100                 105                 110         

Pro Asn Arg Cys Asp His Val Gly Ile Tyr Gly Phe Ser Trp Asp Gly 
        115                 120                 125             

Ser Phe Ala Glu Tyr Val Val Val Arg Asn Ala Asn Met Asn Leu Ile 
    130                 135                 140                 

Arg Leu Pro Glu Gly Val Asp Ala Leu Thr Ala Ala Ala Val Gly Cys 
145                 150                 155                 160 

Arg Phe Met Thr Gly Tyr His Gly Val Met Arg Gly Gly Val Arg Pro 
                165                 170                 175     

Gly Gln Trp Val Ala Val His Gly Ala Gly Gly Val Gly Leu Ser Ala 
            180                 185                 190         

Ile Gln Thr Ala Tyr Ala Val Gly Ala Arg Val Ile Ala Val Asp Val 
        195                 200                 205             

Asp Asp Glu Lys Leu Ala Lys Ala Arg Glu Glu Gly Ala Cys Glu Val 
    210                 215                 220                 

Val Asn Ala Lys Asn Gln Pro Val Val Glu Ala Ile Arg Glu Ile Thr 
225                 230                 235                 240 

Lys Gly Gly Ala His Val Ser Ile Asp Ala Leu Gly Ile Arg Asp Thr 
                245                 250                 255     

Val Leu Asn Ser Val Leu Ser Leu Arg Lys Gly Gly Arg His Val Gln 
            260                 265                 270         

Ile Gly Leu Thr Thr Ser Gln Glu Gly Gly Phe Val Pro Leu Pro Met 
        275                 280                 285             

Asp Leu Ile Thr Ser Cys Glu Ile Glu Val Val Gly Ser Leu Gly Ile 
    290                 295                 300                 

Pro His Pro Asp Tyr Ala Gly Leu Leu Ala Leu Val Ala Glu Gly Arg 
305                 310                 315                 320 

Leu Arg Pro Arg Asn Leu Val Glu Arg Glu Val Arg Leu Glu Asp Val 
                325                 330                 335     

Gln Glu Val Phe Asp Lys Met Thr Arg Phe Glu Thr Arg Gly Phe Asn 
            340                 345                 350         

Met Ile Thr Ala Phe 
        355         

<210>   590
<211>   357
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   590
Met Glu Arg Glu Arg Gly Gln Ala Val Lys Ala Ala Arg Met Val Gly 
                5                   10                  15      

Phe Arg Glu Pro Leu Val Ile Glu Arg Val Pro Asp Pro Thr Pro Gly 
            20                  25                  30          

Pro Glu Asp Ala Val Ile Arg Val Glu Ala Ser Gly Ile Cys Arg Ser 
        35                  40                  45              

Asp Trp His Gly Trp Met Gly Asp Trp Thr Trp Leu Gly Leu Ser Pro 
    50                  55                  60                  

Gln Leu Pro Ile Thr Pro Gly His Glu Phe Gly Gly Glu Ile Val Ala 
65                  70                  75                  80  

Leu Gly Arg Asp Val Arg Asp Phe Gln Ile Gly Asp Lys Val Thr Val 
                85                  90                  95      

Pro Phe His Tyr Ala Cys Gly His Cys Glu His Cys His Ala Gly Val 
            100                 105                 110         

Pro Asn Arg Cys Asp His Val Gly Ile Tyr Gly Phe Ser Trp Asp Gly 
        115                 120                 125             

Ser Phe Ala Glu Tyr Val Val Val Arg Asn Ala Asn Met Asn Leu Ile 
    130                 135                 140                 

Arg Leu Pro Glu Gly Val Asp Ala Leu Thr Ala Ala Ala Val Gly Cys 
145                 150                 155                 160 

Arg Phe Met Thr Gly Tyr His Gly Val Met Arg Gly Gly Val Arg Pro 
                165                 170                 175     

Gly Gln Trp Val Ala Val His Gly Ala Gly Gly Val Gly Leu Ser Ala 
            180                 185                 190         

Ile Gln Thr Ala Tyr Ala Val Gly Ala Arg Val Ile Ala Val Asp Val 
        195                 200                 205             

Asp Asp Glu Lys Leu Ala Lys Ala Arg Glu Glu Gly Ala Cys Glu Val 
    210                 215                 220                 

Val Asn Ala Lys Asn Gln Pro Val Val Glu Ala Ile Arg Glu Ile Thr 
225                 230                 235                 240 

Lys Gly Gly Ala His Val Ser Ile Asp Ala Leu Gly Ile Arg Asp Thr 
                245                 250                 255     

Val Leu Asn Ser Val Leu Ser Leu Arg Lys Gly Gly Arg His Val Gln 
            260                 265                 270         

Ile Gly Leu Thr Thr Ser Gln Glu Gly Gly Phe Val Pro Leu Pro Met 
        275                 280                 285             

Asp Leu Ile Thr Ser Cys Glu Ile Glu Val Val Gly Ser Leu Gly Ile 
    290                 295                 300                 

Pro His Pro Asp Tyr Ala Gly Leu Leu Ala Leu Val Ala Glu Gly Arg 
305                 310                 315                 320 

Leu Arg Pro Arg Asn Leu Val Glu Arg Glu Val Arg Leu Glu Asp Val 
                325                 330                 335     

Asn Glu Val Phe Asp Lys Met Thr Arg Phe Glu Thr Arg Gly Phe Asn 
            340                 345                 350         

Met Ile Thr Ala Phe 
        355         

<210>   591
<211>   1074
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   591
gtggaaaggg agcgtggaca agccgtgaaa gcagcgagaa tggtgggatt tcgcgagccg       60

ctcgtcatcg agcgcgtgcc ggatccgaca cccgggccgg aggacgccgt gatccgggtg      120

gaggcgagcg gcatctgtcg gagcgactgg catggatgga tgggggactg gacctggctc      180

gggctttcgc cgcagttgcc catcaccccc ggtcacgaat tcggtggcga gatcgtcgca      240

ttggggcggg aggtgcgaga ctttcaatta ggcgacaagg tgacggtgcc gtttcactac      300

gcctgcggac actgtgaaca ctgccacgcg ggcgtgccga accggtgtga tcacgtcggc      360

atctacggct tcagttggga cggcagcttc gcggaatatg tggtcgttcg aaacgcgaat      420

atgaacctga ttcgcctgcc ggaaggcgtc gacgccctta cggcagccgc cgtagggtgc      480

cggtttatga ccgggtatca cggcgtgatg cggggaggcg tgaggcccgg acagtgggtg      540

gcggtgcacg gcgcaggtgg cgtgggcctc tcggccattc agacggcgta cgccgtgggc      600

gcgcgcgtga ttgcggtcga tgtggacgac gagaagctgg ccaaagcgcg cgaggaaggc      660

gcgtgtgagg ttgtgaacgc aaaaaaccag cccgtggtgg aggccatccg ggagatcacc      720

aagggcgggg cccacgtgag catcgatgcg ttgggcattc gggacacggt cctgaactcc      780

gtattgagcc ttcgcaaggg aggcaggcac gtgcagattg gtctcaccac gtcccaagag      840

ggtgggtttg tgccgcttcc catggatctc atcacgagtt gcgagattga ggtcgtgggg      900

agcctcggca ttccgcaccc ggactacgcg gggctcctcg cgttggttgc cgaaggtcgc      960

ctgaggccga gaaacctggt ggagcgagag gtccgactcg aagatgtcaa cgaggtgttc     1020

gacaaaatga cgcggtttga aaccagaggt ttcaacatga tcacggcgtt ctga           1074


<210>   592
<211>   1074
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   592
gtggaaaggg agcgtggaca agccgtgaaa gcagcgagaa tggtgggatt tcgcgagccg       60

ctcgtcatcg agcgcgtgcc ggatccgaca cccgggccgg aggacgccgt gatccgggtg      120

gaggcgagcg gcatctgtcg gagcgactgg catggatgga tgggggactg gacctggctc      180

gggctttcgc cgcagttgcc catcaccccc ggtcacgaat tcggtggcga gatcgtcgca      240

ttggggcggg aggtgcgaga ctttcaaatc ggcgacaagg tgacggtgcc gtttcactac      300

gcctgcggac actgtgaaca ctgccacgcg ggcgtgccga accggtgtga tcacgtcggc      360

atctacggct tcagttggga cggcagcttc gcggaatatg tggtcgttcg aaacgcgaat      420

atgaacctga ttcgcctgcc ggaaggcgtc gacgccctta cggcagccgc cgtagggtgc      480

cggtttatga ccgggtatca cggcgtgatg cggggaggcg tgaggcccgg acagtgggtg      540

gcggtgcacg gcgcaggtgg cgtgggcctc tcggccattc agacggcgta cgccgtgggc      600

gcgcgcgtga ttgcggtcga tgtggacgac gagaagctgg ccaaagcgcg cgaggaaggc      660

gcgtgtgagg ttgtgaacgc aaaaaaccag cccgtggtgg aggccatccg ggagatcacc      720

aagggcgggg cccacgtgag catcgatgcg ttgggcattc gggacacggt cctgaactcc      780

gtattgagcc ttcgcaaggg aggcaggcac gtgcagattg gtctcaccac gtcccaagat      840

ggtgggtttg tgccgcttcc catggatctc atcacgagtt gcgagattga ggtcgtgggg      900

agcctcggca ttccgcaccc ggactacgcg gggctcctcg cgttggttgc cgaaggtcgc      960

ctgaggccga gaaacctggt ggagcgagag gtccgactcg aagatgtcaa cgaggtgttc     1020

gacaaaatga cgcggtttga aaccagaggt ttcaacatga tcacggcgtt ctga           1074


<210>   593
<211>   1074
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   593
gtggaaaggg agcgtggaca agccgtgaaa gcagcgagaa tggtgggatt tcgcgagccg       60

ctcgtcatcg agcgcgtgcc ggatccgaca cccgggccgg aggacgccgt gatccgggtg      120

gaggcgagcg gcatctgtcg gagcgactgg catggatgga tgggggactg gacctggctc      180

gggctttcgc cgcagattcc catcaccccc ggtcacgaat tcggtggcga gatcgtcgca      240

ttggggcggg aggtgcgaga ctttcaaatc ggcgacaagg tgacggtgcc gtttcactac      300

gcctgcggac actgtgaaca ctgccacgcg ggcgtgccga accggtgtga tcacgtcggc      360

atctacggct tcagttggga cggcagcttc gcggaatatg tggtcgttcg aaacgcgaat      420

atgaacctga ttcgcctgcc ggaaggcgtc gacgccctta cggcagccgc cgtagggtgc      480

cggtttatga ccgggtatca cggcgtgatg cggggaggcg tgaggcccgg acagtgggtg      540

gcggtgcacg gcgcaggtgg cgtgggcctc tcggccattc agacggcgta cgccgtgggc      600

gcgcgcgtga ttgcggtcga tgtggacgac gagaagctgg ccaaagcgcg cgaggaaggc      660

gcgtgtgagg ttgtgaacgc aaaaaaccag cccgtggtgg aggccatccg ggagatcacc      720

aagggcgggg cccacgtgag catcgatgcg ttgggcattc gggacacggt cctgaactcc      780

gtattgagcc ttcgcaaggg aggcaggcac gtgcagattg gtctcaccac gtcccaagag      840

ggtgggtttg tgccgcttcc catggatctc atcacgagtt gcgagattga ggtcgtgggg      900

agcctcggca ttccgcaccc ggactacgcg gggctcctcg cgttggttgc cgaaggtcgc      960

ctgaggccga gaaacctggt ggagcgagag gtccgactcg aagatgtcaa cgaggtgttc     1020

gacaaaatga cgcggtttga aaccagaggt ttcaacatga tcacggcgtt ctga           1074


<210>   594
<211>   1074
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   594
gtggaaaggg agcgtggaca agccgtgaaa gcagcgagaa tggtgggatt tcgcgagccg       60

ctcgtcatcg agcgcgtgcc ggatccgaca cccgggccgg aggacgccgt gatccgggtg      120

gaggcgagcg gcatctgtcg gagcgactgg catggatgga tgggggactg gacctggctc      180

gggctttcgc cgcagttgcc catcaccccc ggtcacgaat tcggtggcga gatcgtcgca      240

ttggggcggg aggtgcgaga ctttcaaatc ggcgacaagg tgacggtgcc gtttcactac      300

gcctgcggac actgtgaaca ctgccacgcg ggcgtgccga accggtgtga tcacgtcggc      360

atctacggct tcagttggga cggcagcttc gcggaatatg tggtcgttcg aaacgcgaat      420

atgaacctga ttcgcctgcc ggaaggcgtc gacgccctta cggcagccgc cgtagggtgc      480

cggtttatga ccgggtatca cggcgtgatg cggggaggcg tgaggcccgg acagtgggtg      540

gcggtgcacg gcgcaggtgg cgtgggcctc tcggccattc agacggcgta cgccgtgggc      600

gcgcgcgtga ttgcggtcga tgtggacgac gagaagctgg ccaaagcgcg cgaggaaggc      660

gcgtgtgagg ttgtgaacgc aaaaaaccag cccgtggtgg aggccatccg ggagatcacc      720

aagggcgggg cccacgtgag catcgatgcg ttgggcattc gggacacggt cctgaactcc      780

gtattgagcc ttcgcaaggg aggcaggcac gtgcagattg gtctcaccac gtcccaagag      840

ggtgggtttg tgccgcttcc catggatctc atcacgagtt gcgagattga ggtcgtgggg      900

agcctcggca ttccgcaccc ggactacgcg gggctcctcg cgttggttgc cgaaggtcgc      960

ctgaggccga gaaacctggt ggagcgagag gtccgactcg aagatgtcca agaggtgttc     1020

gacaaaatga cgcggtttga aaccagaggt ttcaacatga tcacggcgtt ctga           1074


<210>   595
<211>   1074
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   595
gtggaaaggg agcgtggaca agccgtgaaa gcagcgagaa tggtgggatt tcgcgagccg       60

ctcgtcatcg agcgcgtgcc ggatccgaca cccgggccgg aggacgccgt gatccgggtg      120

gaggcgagcg gcatctgtcg gagcgactgg catggatgga tgggggactg gacctggctc      180

gggctttcgc cgcagttgcc catcaccccc ggtcacgaat tcggtggcga gatcgtcgca      240

ttggggcggg atgtgcgaga ctttcaaatc ggcgacaagg tgacggtgcc gtttcactac      300

gcctgcggac actgtgaaca ctgccacgcg ggcgtgccga accggtgtga tcacgtcggc      360

atctacggct tcagttggga cggcagcttc gcggaatatg tggtcgttcg aaacgcgaat      420

atgaacctga ttcgcctgcc ggaaggcgtc gacgccctta cggcagccgc cgtagggtgc      480

cggtttatga ccgggtatca cggcgtgatg cggggaggcg tgaggcccgg acagtgggtg      540

gcggtgcacg gcgcaggtgg cgtgggcctc tcggccattc agacggcgta cgccgtgggc      600

gcgcgcgtga ttgcggtcga tgtggacgac gagaagctgg ccaaagcgcg cgaggaaggc      660

gcgtgtgagg ttgtgaacgc aaaaaaccag cccgtggtgg aggccatccg ggagatcacc      720

aagggcgggg cccacgtgag catcgatgcg ttgggcattc gggacacggt cctgaactcc      780

gtattgagcc ttcgcaaggg aggcaggcac gtgcagattg gtctcaccac gtcccaagag      840

ggtgggtttg tgccgcttcc catggatctc atcacgagtt gcgagattga ggtcgtgggg      900

agcctcggca ttccgcaccc ggactacgcg gggctcctcg cgttggttgc cgaaggtcgc      960

ctgaggccga gaaacctggt ggagcgagag gtccgactcg aagatgtcaa cgaggtgttc     1020

gacaaaatga cgcggtttga aaccagaggt ttcaacatga tcacggcgtt ctga           1074


<210>   596
<211>   232
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   596
Met Arg Ser Leu Pro Leu Leu Lys Ile Cys Gly Leu Arg Pro Gly Asp 
                5                   10                  15      

Asp Leu Ser Phe Leu Arg His Pro Ala Val Thr His Val Gly Val Val 
            20                  25                  30          

Met Val Pro Ala Ser Arg Arg Tyr Val Ser Pro Asp Glu Ala Gly Asp 
        35                  40                  45              

Leu Val Arg Thr Ala Lys Arg Leu Arg Pro Asp Val Thr Thr Val Ala 
    50                  55                  60                  

Val Val Ser Gly Gly Ser Arg Glu Glu Ile Gly Glu Gly Ala Arg Arg 
65                  70                  75                  80  

Ala Gly Val Asp Val Val Gln Leu His Gly Gly Glu Pro Arg Asp Val 
                85                  90                  95      

Ala Glu Arg Leu Arg Glu Ala Gly Phe Arg Val Trp Arg Ala Val Ala 
            100                 105                 110         

Phe Asp Pro Gly Asp Asp Val Thr Ser Phe Leu Asp Thr Leu Arg Ser 
        115                 120                 125             

His Ala Ser Ser Ala Asp Ala Ile Leu Phe Asp Ala Lys Pro Pro Ser 
    130                 135                 140                 

Asp Ala Lys Pro Gly Val Thr Gly Gly His Gly Arg Ala Phe Asp Trp 
145                 150                 155                 160 

Asp Arg Leu Ala Glu Met Ala Arg Ala Phe Ser Phe Asp Trp Trp Val 
                165                 170                 175     

Ala Gly Gly Ile Thr Pro Glu Asn Val Arg Asp Leu Leu Arg Arg Val 
            180                 185                 190         

Arg Pro Val Gly Ile Asp Val Ser Ser Gly Val Glu Val Gly Gly Arg 
        195                 200                 205             

Lys Asp Val Arg Arg Ile Asp Gln Leu Ile Gln Ala Met Glu Ala Trp 
    210                 215                 220                 

Gly His Glu Ser Leu Ser Leu Ser 
225                 230         

<210>   597
<211>   699
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   597
gtgagaagcc tcccgctttt gaaaatctgc ggacttcggc cgggcgacga tctgtcgttt       60

cttcgccatc ccgccgtcac gcatgtgggc gtcgtgatgg tcccggcgtc caggcgctac      120

gtgtccccgg acgaggcggg cgatctcgtc cgaaccgcga agcgcctccg cccggatgtg      180

accaccgttg cggtggtctc aggcggatcg cgcgaagaga tcggggaggg tgcgaggagg      240

gccggcgtcg acgtggtgca gttgcacgga ggtgaacctc gggacgtcgc ggagaggctt      300

cgcgaagctg ggtttcgggt gtggcgcgcg gtcgcgttcg atcccggaga cgatgtgact      360

tcttttctgg ataccttgag gtcgcatgcg tcttccgccg acgccatcct gttcgatgcg      420

aaaccgccat cggacgcgaa acccggcgtc acgggcgggc acggtcgagc gttcgactgg      480

gatcgcttgg ccgagatggc gcgggcgttc agcttcgatt ggtgggtcgc gggcggaatc      540

acgccggaaa acgttcggga cctcctgcgc cgggtgcggc cagtcggcat cgacgtgtct      600

tcgggcgtgg aagtcggcgg gcggaaggac gtccgccgca ttgatcagtt gattcaggcg      660

atggaggcgt ggggccatga gtcattatcc ttatcctga                             699


<210>   598
<211>   203
<212>   PRT
<213>   Paracoccus denitrificans PD1222

<400>   598
Val Lys Ile Cys Gly Leu Thr Glu Ala Ala Gly Leu Ala Ala Ala Val 
                5                   10                  15      

Asp Ala Gly Ala Arg Tyr Val Gly Phe Val Phe Phe Pro Lys Ser Pro 
            20                  25                  30          

Arg His Val Thr Pro Gly Thr Ala Ala Glu Leu Ala Ala Gln Val Pro 
        35                  40                  45              

Leu Gly Val Ala Lys Val Gly Leu Phe Val Asn Pro Asp Asp Ala Ala 
    50                  55                  60                  

Leu Asp Ala Val Leu Ala His Val Pro Leu Asp Val Ile Gln Leu His 
65                  70                  75                  80  

Gly Ala Glu Thr Pro Ala Arg Val Ala Glu Val Lys Ala Arg Thr Gly 
                85                  90                  95      

Leu Pro Val Met Lys Ala Val Gly Val Ala Asp Pro Gln Asp Leu Asp 
            100                 105                 110         

Ala Leu Trp Asp Tyr Gly Leu Val Ala Asp Met Leu Leu Ile Asp Ala 
        115                 120                 125             

Lys Pro Pro Lys Asp Ala Val Leu Pro Gly Gly Asn Gly Leu Ala Phe 
    130                 135                 140                 

Asp Trp Arg Leu Leu Ala Gly Arg Gln Ile Leu Lys Pro Trp Leu Leu 
145                 150                 155                 160 

Ala Gly Gly Leu Thr Pro Glu Asn Val His Glu Ala Ile Arg Leu Thr 
                165                 170                 175     

Arg Ala Pro Gly Val Asp Val Ser Ser Gly Val Glu Ser Ala Pro Gly 
            180                 185                 190         

Val Lys Asp Pro Asp Arg Ile Arg Ser Phe Ile 
        195                 200             

<210>   599
<211>   203
<212>   PRT
<213>   Paracoccus denitrificans PD1222

<400>   599
Val Lys Ile Cys Gly Leu Thr Glu Ala Ala Gly Leu Ala Ala Ala Val 
                5                   10                  15      

Asp Ala Gly Ala Arg Tyr Val Gly Phe Val Phe Phe Pro Lys Ser Pro 
            20                  25                  30          

Arg His Val Thr Pro Gly Thr Ala Ala Glu Leu Ala Ala Gln Val Pro 
        35                  40                  45              

Leu Gly Val Ala Lys Val Gly Leu Phe Val Asn Pro Asp Asp Ala Ala 
    50                  55                  60                  

Leu Asp Ala Val Leu Ala His Val Pro Leu Asp Val Ile Gln Leu His 
65                  70                  75                  80  

Gly Ala Glu Thr Pro Ala Arg Val Ala Glu Val Lys Ala Arg Thr Gly 
                85                  90                  95      

Leu Pro Val Met Lys Ala Val Gly Val Ala Asp Pro Gln Asp Leu Asp 
            100                 105                 110         

Ala Leu Trp Asp Tyr Gly Leu Val Ala Asp Met Leu Leu Ile Asp Ala 
        115                 120                 125             

Lys Pro Pro Lys Asp Ala Val Leu Pro Gly Gly Asn Gly Leu Ala Phe 
    130                 135                 140                 

Asp Trp Arg Leu Leu Ala Gly Arg Gln Ile Leu Lys Pro Trp Leu Leu 
145                 150                 155                 160 

Ala Gly Gly Leu Thr Pro Glu Asn Val His Glu Ala Ile Arg Leu Thr 
                165                 170                 175     

Arg Ala Pro Gly Val Asp Val Ser Ser Gly Val Glu Ser Ala Pro Gly 
            180                 185                 190         

Val Lys Asp Pro Asp Arg Ile Arg Ser Phe Ile 
        195                 200             

<210>   600
<211>   215
<212>   PRT
<213>   Brucella ovis ATCC 25840

<400>   600
Met Arg Arg Lys Pro Met Ala Leu Asp Ile Lys Ile Cys Gly Leu Lys 
                5                   10                  15      

Thr Pro Glu Ala Val Ala Ala Ala Leu Asp Gly Gly Ala Thr His Ile 
            20                  25                  30          

Gly Phe Ile Phe Phe Pro Lys Ser Pro Arg His Ile Thr Pro Asp Ala 
        35                  40                  45              

Ala Ala Arg Leu Arg Ala Ala Ala Thr Gly Arg Ala Val Thr Val Ala 
    50                  55                  60                  

Val Thr Val Asp Ala Asp Asp Glu Ala Leu Asp Glu Ile Val Lys Thr 
65                  70                  75                  80  

Val Arg Pro Asp Met Leu Gln Leu His Gly Gly Glu Thr Pro Glu Arg 
                85                  90                  95      

Val Arg Phe Leu Lys Glu Arg Tyr Asn Leu Pro Val Met Lys Ala Phe 
            100                 105                 110         

Ser Ile Arg Glu Ala Gly Asp Leu Glu Ala Ile Ala Pro Tyr Arg Gly 
        115                 120                 125             

Ile Ala Asp Arg Phe Leu Phe Asp Ala Lys Pro Pro Lys Gly Ser Glu 
    130                 135                 140                 

Leu Pro Gly Gly Asn Gly Ile Ser Phe Asp Trp Asn Leu Leu Ala Ala 
145                 150                 155                 160 

Leu Asp Ala Asp Ile Asp Tyr Met Leu Ser Gly Gly Leu Asn Ala Asp 
                165                 170                 175     

Asn Ile Ala Glu Ala Leu Leu Lys Thr Gly Ala Pro Gly Ile Asp Ile 
            180                 185                 190         

Ser Ser Gly Val Glu Cys Ala Pro Gly Glu Lys Asp Val Arg Leu Ile 
        195                 200                 205             

Glu Asn Phe Phe Gln Ala Val 
    210                 215 

<210>   601
<211>   208
<212>   PRT
<213>   Mesorhizobium loti MAFF303099

<400>   601
Ile Lys Ile Cys Gly Leu Lys Thr Asp Gln Ala Met Ala Ala Ala Leu 
                5                   10                  15      

Gly Gly Gly Ala Ser His Val Gly Phe Ile Phe Phe Ala Lys Ser Pro 
            20                  25                  30          

Arg Tyr Val Glu Pro Ala Glu Ala Gly Arg Leu Arg Glu Ala Ala Arg 
        35                  40                  45              

Gly Lys Ala Val Ala Val Ala Val Thr Val Asp Ala Thr Asp Ala Phe 
    50                  55                  60                  

Leu Asp Glu Ile Val Ser Ala Met Gln Pro Asp Met Leu Gln Leu His 
65                  70                  75                  80  

Gly Ser Glu His Pro Glu Arg Val Ala Glu Leu Lys Ala Arg Tyr Gly 
                85                  90                  95      

Leu Pro Val Met Lys Ala Leu Pro Leu Ser Glu Ala Ala Asp Leu Asp 
            100                 105                 110         

Arg Ile Arg Pro Phe Ile Gly Ile Ala Asp Arg Phe Leu Phe Asp Ala 
        115                 120                 125             

Lys Pro Pro Lys Gly Ser Glu Leu Pro Gly Gly Asn Gly Val Ala Phe 
    130                 135                 140                 

Asp Trp Arg Ile Leu Ala Gly Leu Asp Ala Gly Val Asp Tyr Met Leu 
145                 150                 155                 160 

Ser Gly Gly Leu Asn Ala Ala Asn Ile Gly Asp Ala Leu Arg Leu Ala 
                165                 170                 175     

Asn Pro Pro Gly Ile Asp Ile Ser Ser Gly Val Glu Ser Ala Pro Gly 
            180                 185                 190         

Val Lys Asp Pro Ala Leu Ile Glu Gln Phe Phe Arg Ala Val Arg Ala 
        195                 200                 205             

<210>   602
<211>   206
<212>   PRT
<213>   Oceanicola batsensis HTCC2597

<400>   602
Val Lys Ile Cys Gly Leu Ser Arg Pro Glu Asp Val Ala Ala Ala Ala 
                5                   10                  15      

Arg Ala Gly Ala Val Tyr Gly Gly Phe Val Phe Phe Pro Lys Ser Pro 
            20                  25                  30          

Arg His Val Ser Val Glu Ser Ala Arg Glu Leu Ala Ile Ala Ala Pro 
        35                  40                  45              

Pro Gly Leu Ala Lys Val Ala Leu Ile Val Asp Ala Asp Asp Asp Leu 
    50                  55                  60                  

Ile Asp Arg Ile Thr Ala Thr Val Pro Leu Asp Met Leu Gln Leu His 
65                  70                  75                  80  

Gly Thr Glu Ser Pro Asp Arg Val Ala Glu Val Arg Ala Arg Thr Gly 
                85                  90                  95      

Leu Pro Val Met Lys Ala Val Gly Leu Ser Glu Ala Ala Asp Leu Ala 
            100                 105                 110         

Ala Ile Asp Leu Tyr Ser Glu Val Ala Asp Gln Leu Leu Ile Asp Ala 
        115                 120                 125             

Lys Pro Pro Lys Glu Ala Ser Ile Pro Gly Gly Asn Gly Leu Ala Phe 
    130                 135                 140                 

Asp Trp Arg Leu Leu Gln Gln Arg Lys Tyr Trp Ser Arg Pro Trp Met 
145                 150                 155                 160 

Leu Ala Gly Gly Leu Thr Pro Asp Asn Val Ala Glu Ala Ile Arg Leu 
                165                 170                 175     

Thr Gly Ala Arg Gln Val Asp Val Ser Ser Gly Val Glu Ala Gly Arg 
            180                 185                 190         

Gly Ile Lys Asp Pro Glu Arg Ile Ala Gly Phe Val Ala Ala 
        195                 200                 205     

<210>   603
<211>   232
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   603
Met Arg Ser Leu Pro Leu Leu Lys Ile Cys Gly Leu Arg Pro Gly Asp 
                5                   10                  15      

Asp Leu Ser Phe Leu Arg His Pro Ala Val Thr His Val Gly Val Val 
            20                  25                  30          

Met Val Pro Ala Ser Arg Arg Tyr Val Ser Pro Asp Glu Ala Gly Asp 
        35                  40                  45              

Leu Val Arg Thr Ala Lys Arg Leu Arg Pro Asp Val Thr Thr Val Ala 
    50                  55                  60                  

Val Val Ser Gly Gly Ser Arg Glu Glu Ile Gly Glu Gly Ala Arg Arg 
65                  70                  75                  80  

Ala Gly Val Asp Val Val Gln Leu His Gly Gly Glu Pro Arg Asp Val 
                85                  90                  95      

Ala Glu Arg Leu Arg Glu Ala Gly Phe Arg Val Trp Arg Ala Val Ala 
            100                 105                 110         

Phe Asp Pro Gly Asp Asp Val Thr Ser Phe Leu Asp Thr Leu Arg Ser 
        115                 120                 125             

His Ala Ser Ser Ala Asp Ala Ile Leu Phe Asp Ala Lys Pro Pro Ser 
    130                 135                 140                 

Asp Ala Lys Pro Gly Val Thr Gly Gly His Gly Lys Ala Phe Asp Trp 
145                 150                 155                 160 

Asp Arg Leu Ala Glu Met Ala Arg Ala Phe Ser Phe Asp Trp Trp Val 
                165                 170                 175     

Ala Gly Gly Ile Thr Pro Glu Asn Val Arg Asp Leu Leu Arg Arg Val 
            180                 185                 190         

Arg Pro Val Gly Ile Asp Val Ser Ser Gly Val Glu Val Gly Gly Arg 
        195                 200                 205             

Lys Asp Val Arg Arg Ile Asp Gln Leu Ile Gln Ala Met Glu Ala Trp 
    210                 215                 220                 

Gly His Glu Ser Leu Ser Leu Ser 
225                 230         

<210>   604
<211>   232
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   604
Met Arg Ser Leu Pro Leu Leu Lys Ile Cys Gly Leu Arg Pro Gly Asp 
                5                   10                  15      

Asp Leu Ser Phe Leu Arg His Pro Ala Val Thr His Val Gly Val Val 
            20                  25                  30          

Met Val Pro Ala Ser Arg Arg Tyr Val Ser Pro Asp Glu Ala Gly Asp 
        35                  40                  45              

Leu Val Arg Thr Ala Lys Arg Leu Arg Pro Asp Val Thr Thr Val Ala 
    50                  55                  60                  

Val Val Ser Gly Gly Ser Arg Glu Glu Ile Gly Glu Gly Ala Arg Arg 
65                  70                  75                  80  

Ala Gly Val Asp Val Val Gln Leu His Gly Gly Glu Pro Arg Asp Val 
                85                  90                  95      

Ala Glu Arg Leu Arg Glu Ala Gly Phe Arg Val Trp Arg Ala Val Ala 
            100                 105                 110         

Phe Asp Pro Gly Asp Asp Val Thr Ser Phe Leu Asp Thr Leu Arg Ser 
        115                 120                 125             

His Ala Ser Ser Ala Asp Ala Ile Leu Phe Asp Ala Lys Pro Pro Ser 
    130                 135                 140                 

Asp Ala Lys Pro Gly Val Thr Gly Gly His Gly Arg Ala Phe Asp Trp 
145                 150                 155                 160 

Asp Arg Leu Ala Glu Met Ala Arg Ala Phe Ser Phe Asp Trp Trp Val 
                165                 170                 175     

Ala Gly Gly Ile Thr Pro Glu Asn Val Arg Asp Leu Leu Arg Arg Val 
            180                 185                 190         

Arg Pro Val Gly Ile Asp Val Ser Ser Gly Val Glu Val Gly Gly Arg 
        195                 200                 205             

Lys Asp Val Arg Arg Ile Asp Gln Leu Ile Gln Ala Met Asp Ala Trp 
    210                 215                 220                 

Gly His Glu Ser Leu Ser Leu Ser 
225                 230         

<210>   605
<211>   232
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   605
Met Arg Ser Leu Pro Leu Leu Lys Ile Cys Gly Leu Arg Pro Gly Asp 
                5                   10                  15      

Asp Leu Ser Phe Leu Arg His Pro Ala Val Thr His Val Gly Val Val 
            20                  25                  30          

Met Val Pro Ala Ser Arg Arg Tyr Val Ser Pro Asp Glu Ala Gly Asp 
        35                  40                  45              

Leu Val Arg Thr Ala Lys Arg Leu Arg Pro Asp Val Thr Thr Val Ala 
    50                  55                  60                  

Val Val Ser Gly Gly Ser Arg Glu Glu Ile Gly Glu Gly Ala Arg Arg 
65                  70                  75                  80  

Ala Gly Val Asp Val Val Gln Leu His Gly Gly Glu Pro Arg Glu Val 
                85                  90                  95      

Ala Glu Arg Leu Arg Glu Ala Gly Phe Arg Val Trp Arg Ala Val Ala 
            100                 105                 110         

Phe Asp Pro Gly Asp Asp Val Thr Ser Phe Leu Asp Thr Leu Arg Ser 
        115                 120                 125             

His Ala Ser Ser Ala Asp Ala Ile Leu Phe Asp Ala Lys Pro Pro Ser 
    130                 135                 140                 

Asp Ala Lys Pro Gly Val Thr Gly Gly His Gly Arg Ala Phe Asp Trp 
145                 150                 155                 160 

Asp Arg Leu Ala Glu Met Ala Arg Ala Phe Ser Phe Asp Trp Trp Val 
                165                 170                 175     

Ala Gly Gly Ile Thr Pro Glu Asn Val Arg Asp Leu Leu Arg Arg Val 
            180                 185                 190         

Arg Pro Val Gly Ile Asp Val Ser Ser Gly Val Glu Val Gly Gly Arg 
        195                 200                 205             

Lys Asp Val Arg Arg Ile Asp Gln Leu Ile Gln Ala Met Glu Ala Trp 
    210                 215                 220                 

Gly His Glu Ser Leu Ser Leu Ser 
225                 230         

<210>   606
<211>   232
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   606
Met Arg Ser Leu Pro Leu Leu Lys Ile Cys Gly Leu Arg Pro Gly Asp 
                5                   10                  15      

Asp Leu Ser Phe Leu Arg His Pro Ala Val Thr His Val Gly Val Val 
            20                  25                  30          

Met Val Pro Ala Ser Arg Arg Tyr Val Ser Pro Asp Glu Ala Gly Asp 
        35                  40                  45              

Leu Val Arg Thr Ala Lys Arg Leu Arg Pro Asp Val Thr Thr Val Ala 
    50                  55                  60                  

Val Val Ser Gly Gly Ser Arg Glu Glu Ile Gly Glu Gly Ala Arg Arg 
65                  70                  75                  80  

Ala Gly Val Asp Val Val Gln Leu His Gly Gly Glu Pro Arg Asp Val 
                85                  90                  95      

Ala Glu Arg Leu Arg Glu Ala Gly Phe Arg Val Trp Arg Ala Val Ala 
            100                 105                 110         

Phe Asp Pro Gly Asp Asp Val Thr Ser Phe Leu Asp Thr Leu Arg Ser 
        115                 120                 125             

His Ala Ser Ser Ala Asp Ala Ile Leu Phe Asp Ala Lys Pro Pro Ser 
    130                 135                 140                 

Asp Ala Lys Pro Gly Val Thr Gly Gly His Gly Arg Ala Phe Asp Trp 
145                 150                 155                 160 

Asp Arg Leu Ala Glu Met Ala Arg Ala Phe Ser Phe Asp Trp Trp Val 
                165                 170                 175     

Ala Gly Gly Ile Thr Pro Glu Asn Val Lys Asp Leu Leu Arg Arg Val 
            180                 185                 190         

Arg Pro Val Gly Ile Asp Val Ser Ser Gly Val Glu Val Gly Gly Arg 
        195                 200                 205             

Lys Asp Val Arg Arg Ile Asp Gln Leu Ile Gln Ala Met Glu Ala Trp 
    210                 215                 220                 

Gly His Glu Ser Leu Ser Leu Ser 
225                 230         

<210>   607
<211>   232
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   607
Met Arg Ser Leu Pro Leu Leu Lys Ile Cys Gly Leu Arg Pro Gly Asp 
                5                   10                  15      

Asp Leu Ser Phe Leu Arg His Pro Ala Val Thr His Val Gly Val Val 
            20                  25                  30          

Met Val Pro Ala Ser Arg Arg Tyr Val Ser Pro Asp Glu Ala Gly Asp 
        35                  40                  45              

Leu Val Arg Thr Ala Lys Arg Leu Arg Pro Asp Val Thr Thr Val Ala 
    50                  55                  60                  

Val Val Ser Gly Gly Ser Arg Glu Glu Ile Gly Asp Gly Ala Arg Arg 
65                  70                  75                  80  

Ala Gly Val Asp Val Val Gln Leu His Gly Gly Glu Pro Arg Asp Val 
                85                  90                  95      

Ala Glu Arg Leu Arg Glu Ala Gly Phe Arg Val Trp Arg Ala Val Ala 
            100                 105                 110         

Phe Asp Pro Gly Asp Asp Val Thr Ser Phe Leu Asp Thr Leu Arg Ser 
        115                 120                 125             

His Ala Ser Ser Ala Asp Ala Ile Leu Phe Asp Ala Lys Pro Pro Ser 
    130                 135                 140                 

Asp Ala Lys Pro Gly Val Thr Gly Gly His Gly Arg Ala Phe Asp Trp 
145                 150                 155                 160 

Asp Arg Leu Ala Glu Met Ala Arg Ala Phe Ser Phe Asp Trp Trp Val 
                165                 170                 175     

Ala Gly Gly Ile Thr Pro Glu Asn Val Arg Asp Leu Leu Arg Arg Val 
            180                 185                 190         

Arg Pro Val Gly Ile Asp Val Ser Ser Gly Val Glu Val Gly Gly Arg 
        195                 200                 205             

Lys Asp Val Arg Arg Ile Asp Gln Leu Ile Gln Ala Met Glu Ala Trp 
    210                 215                 220                 

Gly His Glu Ser Leu Ser Leu Ser 
225                 230         

<210>   608
<211>   699
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   608
gtgagaagcc tcccgctttt gaaaatctgc ggacttcggc cgggcgacga tctgtcgttt       60

cttcgccatc ccgccgtcac gcatgtgggc gtcgtgatgg tcccggcgtc caggcgctac      120

gtgtccccgg acgaggcggg cgatctcgtc cgaaccgcga agcgcctccg cccggatgtg      180

accaccgttg cggtggtctc aggcggatcg cgcgaagaga tcggggaggg tgcgaggagg      240

gccggcgtcg acgtggtgca gttgcacgga ggtgaacctc gggacgtcgc ggagaggctt      300

cgcgaagctg ggtttcgggt gtggcgcgcg gtcgcgttcg atcccggaga cgatgtgact      360

tcttttctgg ataccttgag gtcgcatgcg tcttccgccg acgccatcct gttcgatgcg      420

aaaccgccat cggacgcgaa acccggcgtc acgggcgggc acggtaaagc gttcgactgg      480

gatcgcttgg ccgagatggc gcgggcgttc agcttcgatt ggtgggtcgc gggcggaatc      540

acgccggaaa acgttcggga cctcctgcgc cgggtgcggc cagtcggcat cgacgtgtct      600

tcgggcgtgg aagtcggcgg gcggaaggac gtccgccgca ttgatcagtt gattcaggcg      660

atggaggcgt ggggccatga gtcattatcc ttatcctga                             699


<210>   609
<211>   699
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   609
gtgagaagcc tcccgctttt gaaaatctgc ggacttcggc cgggcgacga tctgtcgttt       60

cttcgccatc ccgccgtcac gcatgtgggc gtcgtgatgg tcccggcgtc caggcgctac      120

gtgtccccgg acgaggcggg cgatctcgtc cgaaccgcga agcgcctccg cccggatgtg      180

accaccgttg cggtggtctc aggcggatcg cgcgaagaga tcggggaggg tgcgaggagg      240

gccggcgtcg acgtggtgca gttgcacgga ggtgaacctc gggacgtcgc ggagaggctt      300

cgcgaagctg ggtttcgggt gtggcgcgcg gtcgcgttcg atcccggaga cgatgtgact      360

tcttttctgg ataccttgag gtcgcatgcg tcttccgccg acgccatcct gttcgatgcg      420

aaaccgccat cggacgcgaa acccggcgtc acgggcgggc acggtcgagc gttcgactgg      480

gatcgcttgg ccgagatggc gcgggcgttc agcttcgatt ggtgggtcgc gggcggaatc      540

acgccggaaa acgttcggga cctcctgcgc cgggtgcggc cagtcggcat cgacgtgtct      600

tcgggcgtgg aagtcggcgg gcggaaggac gtccgccgca ttgatcagtt gattcaggcg      660

atggatgcgt ggggccatga gtcattatcc ttatcctga                             699


<210>   610
<211>   699
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   610
gtgagaagcc tcccgctttt gaaaatctgc ggacttcggc cgggcgacga tctgtcgttt       60

cttcgccatc ccgccgtcac gcatgtgggc gtcgtgatgg tcccggcgtc caggcgctac      120

gtgtccccgg acgaggcggg cgatctcgtc cgaaccgcga agcgcctccg cccggatgtg      180

accaccgttg cggtggtctc aggcggatcg cgcgaagaga tcggggaggg tgcgaggagg      240

gccggcgtcg acgtggtgca gttgcacgga ggtgaacctc gggaagtcgc ggagaggctt      300

cgcgaagctg ggtttcgggt gtggcgcgcg gtcgcgttcg atcccggaga cgatgtgact      360

tcttttctgg ataccttgag gtcgcatgcg tcttccgccg acgccatcct gttcgatgcg      420

aaaccgccat cggacgcgaa acccggcgtc acgggcgggc acggtcgagc gttcgactgg      480

gatcgcttgg ccgagatggc gcgggcgttc agcttcgatt ggtgggtcgc gggcggaatc      540

acgccggaaa acgttcggga cctcctgcgc cgggtgcggc cagtcggcat cgacgtgtct      600

tcgggcgtgg aagtcggcgg gcggaaggac gtccgccgca ttgatcagtt gattcaggcg      660

atggaggcgt ggggccatga gtcattatcc ttatcctga                             699


<210>   611
<211>   699
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   611
gtgagaagcc tcccgctttt gaaaatctgc ggacttcggc cgggcgacga tctgtcgttt       60

cttcgccatc ccgccgtcac gcatgtgggc gtcgtgatgg tcccggcgtc caggcgctac      120

gtgtccccgg acgaggcggg cgatctcgtc cgaaccgcga agcgcctccg cccggatgtg      180

accaccgttg cggtggtctc aggcggatcg cgcgaagaga tcggggaggg tgcgaggagg      240

gccggcgtcg acgtggtgca gttgcacgga ggtgaacctc gggacgtcgc ggagaggctt      300

cgcgaagctg ggtttcgggt gtggcgcgcg gtcgcgttcg atcccggaga cgatgtgact      360

tcttttctgg ataccttgag gtcgcatgcg tcttccgccg acgccatcct gttcgatgcg      420

aaaccgccat cggacgcgaa acccggcgtc acgggcgggc acggtcgagc gttcgactgg      480

gatcgcttgg ccgagatggc gcgggcgttc agcttcgatt ggtgggtcgc gggcggaatc      540

acgccggaaa acgttaaaga cctcctgcgc cgggtgcggc cagtcggcat cgacgtgtct      600

tcgggcgtgg aagtcggcgg gcggaaggac gtccgccgca ttgatcagtt gattcaggcg      660

atggaggcgt ggggccatga gtcattatcc ttatcctga                             699


<210>   612
<211>   699
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   612
gtgagaagcc tcccgctttt gaaaatctgc ggacttcggc cgggcgacga tctgtcgttt       60

cttcgccatc ccgccgtcac gcatgtgggc gtcgtgatgg tcccggcgtc caggcgctac      120

gtgtccccgg acgaggcggg cgatctcgtc cgaaccgcga agcgcctccg cccggatgtg      180

accaccgttg cggtggtctc aggcggatcg cgcgaagaga tcggggatgg tgcgaggagg      240

gccggcgtcg acgtggtgca gttgcacgga ggtgaacctc gggacgtcgc ggagaggctt      300

cgcgaagctg ggtttcgggt gtggcgcgcg gtcgcgttcg atcccggaga cgatgtgact      360

tcttttctgg ataccttgag gtcgcatgcg tcttccgccg acgccatcct gttcgatgcg      420

aaaccgccat cggacgcgaa acccggcgtc acgggcgggc acggtcgagc gttcgactgg      480

gatcgcttgg ccgagatggc gcgggcgttc agcttcgatt ggtgggtcgc gggcggaatc      540

acgccggaaa acgttcggga cctcctgcgc cgggtgcggc cagtcggcat cgacgtgtct      600

tcgggcgtgg aagtcggcgg gcggaaggac gtccgccgca ttgatcagtt gattcaggcg      660

atggaggcgt ggggccatga gtcattatcc ttatcctga                             699


<210>   613
<211>   497
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   613
Met Ala Val Gln Glu Val Asn Ala Ser Ala Leu His Pro Asp Val Val 
                5                   10                  15      

Glu Phe Leu Lys Gly Pro Lys Gly Leu Phe Ile Asp Gly Glu Phe Val 
            20                  25                  30          

Pro Ser Leu Ser Gly Lys Thr Phe Lys Ser Ile Asn Pro Ala Thr Glu 
        35                  40                  45              

Glu Val Leu Val Glu Val Ala Glu Ala Glu Ala Pro Asp Ile Asp Arg 
    50                  55                  60                  

Ala Val Lys Ala Ala Arg Arg Ala Phe Glu Ser Gly Pro Trp Ser Arg 
65                  70                  75                  80  

Met Ser Ala Ala Glu Arg Ser Arg Leu Leu Tyr Arg Leu Ala Asp Leu 
                85                  90                  95      

Met Glu Glu His Lys Leu Gln Leu Ala Gln Leu Glu Thr Leu Asp Asn 
            100                 105                 110         

Gly Lys Pro Ile Arg Glu Ser Leu Asn Ala Asp Leu Pro Leu Ala Ile 
        115                 120                 125             

Glu His Ile Arg Tyr Tyr Ala Gly Trp Pro Thr Lys Val Val Gly Gln 
    130                 135                 140                 

Thr Ile Pro Val Ala Gly Lys Tyr Phe Asn Tyr Thr Arg His Glu Pro 
145                 150                 155                 160 

Val Gly Val Val Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
                165                 170                 175     

Ala Cys Trp Lys Ile Gly Ala Ala Leu Ala Met Gly Cys Thr Val Val 
            180                 185                 190         

Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Lys 
        195                 200                 205             

Leu Ile Gln Glu Ala Gly Phe Pro Pro Gly Val Val Asn Val Val Pro 
    210                 215                 220                 

Gly Phe Gly Glu Thr Ala Gly Gln Ala Leu Val Glu His Pro Asp Val 
225                 230                 235                 240 

Asn Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Met 
                245                 250                 255     

Arg Asn Ala Ala Ala Thr Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         

Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala Asp Met Ser Arg Ala Ile 
        275                 280                 285             

Pro Gly Ala Phe Met Gly Ile Met Phe Asn Gln Gly Gln Val Cys Cys 
    290                 295                 300                 

Ala Gly Ser Arg Leu Phe Val Gln Lys Lys Ala Tyr Asp Asn Val Val 
305                 310                 315                 320 

Ala Asp Leu Val Ser Leu Ala Lys Lys Ile Arg Gln Gly Pro Gly Leu 
                325                 330                 335     

Asp Gln Gly Thr Glu Met Gly Pro Leu Val Ser Asp Glu Gln Glu Lys 
            340                 345                 350         

Arg Val Leu Gly Tyr Ile Glu Lys Gly Val Glu Glu Gly Ala Glu Val 
        355                 360                 365             

Leu Val Gly Gly Gly Lys Ala Thr Asp Arg Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 

Thr Ile Phe Ala Asn Val Arg Asp Asp Met Thr Ile Ala Arg Glu Glu 
385                 390                 395                 400 

Ile Phe Gly Pro Val Val Ala Ala Met Pro Phe Glu Asp Leu Asp Glu 
                405                 410                 415     

Val Ile Ala Arg Ala Asn Asp Thr Glu Tyr Gly Leu Ala Ala Gly Val 
            420                 425                 430         

Trp Thr Glu Asn Ile Arg Asn Ala His Tyr Ile Ala Ser Lys Leu Lys 
        435                 440                 445             

Ala Gly Thr Val Trp Val Asn Cys Tyr Asn Val Phe Asp Ala Ala Ala 
    450                 455                 460                 

Pro Phe Gly Gly Tyr Lys Gln Ser Gly Ile Gly Arg Glu Met Gly Ser 
465                 470                 475                 480 

Tyr Ala Leu Asn Asn Tyr Thr Glu Val Lys Asp Val Trp Ile Ser Leu 
                485                 490                 495     

Ser 
    

<210>   614
<211>   1494
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   614
gtggcagttc aagaagtgaa tgcgagcgct ctgcatccgg atgtcgtcga gtttctcaag       60

ggtcccaagg gcctgttcat tgacggcgaa ttcgttccct cactctccgg caaaacgttc      120

aagtctatca accctgcgac agaagaagtc ctggtggaag tcgcggaggc ggaagctccc      180

gacattgacc gcgcggtcaa agccgctcgc cgcgcctttg agtccggccc gtggtcgcgc      240

atgagcgccg cggagcggtc ccggcttctc tataggctgg cggatctcat ggaagaacat      300

aagctgcagc tcgctcagct cgaaaccctc gacaacggca aacccattcg cgaatccctg      360

aacgcagacc tgccgcttgc catcgaacac attcgctact acgccggctg gcccaccaag      420

gtcgtggggc aaaccattcc ggtagcggga aaatacttca actacacgcg acacgagccc      480

gtcggcgtcg tgggccagat catcccgtgg aacttcccgc tcctcatggc gtgctggaag      540

attggcgccg cgctggccat gggctgcacg gtggtgctca agccggcgga gcagacgccg      600

ctctccgcgc tctacctggc caaactgatc caagaggctg gcttcccgcc gggcgtcgtc      660

aatgtcgtgc cgggcttcgg cgagaccgcc ggacaggcac tggtggagca cccggacgtc      720

aacaagattg cgttcaccgg atcgacggag gtcggcaagc tcatcatgcg caacgccgcg      780

gcgaccttga agcgcgtcac gctcgagctc ggcggcaagt ccccgaacat cattctcccc      840

gatgccgaca tgagccgagc catccccggc gcgttcatgg gcatcatgtt caaccagggc      900

caggtgtgct gcgccggatc gcgcctgttc gtgcagaaga aagcgtacga caacgtggtg      960

gccgatctcg tctccctcgc gaagaagatc cgccaaggcc cgggcttgga tcaaggcacg     1020

gagatggggc cgctcgtgtc cgatgaacag gagaagcgcg tgctgggcta catcgagaag     1080

ggcgtggaag agggcgccga ggtcctcgtc ggcggcggca aggccacgga tcgcggatac     1140

ttcgtgcagc cgaccatctt cgccaatgtc cgggacgaca tgaccatcgc gcgcgaggag     1200

atcttcggac cggtggtcgc ggcgatgccg tttgaagatt tggacgaagt cattgcgcgc     1260

gcgaacgaca cggagtacgg cctggcggcc ggtgtgtgga cggagaacat ccggaatgcc     1320

cactatatcg ccagcaagct gaaggccggc actgtttggg tcaactgcta caacgtgttt     1380

gacgcggcgg ctcccttcgg tggatacaag cagtccggta tcgggcgcga aatgggctcg     1440

tacgcgttga acaactacac cgaggtcaag gatgtgtgga tcagcctgag ctga           1494


<210>   615
<211>   490
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   615
Ile Ala Ala Pro Lys Leu Lys Glu Lys Val Glu Lys Phe Leu Ser Gly 
                5                   10                  15      

Lys Lys Lys Met Tyr Ile Asn Gly Ser Phe Val Glu Ser Ala Ser Gly 
            20                  25                  30          

Lys Thr Phe Asp Thr Pro Asn Pro Ala Thr Gly Glu Arg Leu Ala Thr 
        35                  40                  45              

Val Tyr Glu Gly Asp Ala Glu Asp Ile Asp Arg Ala Val Lys Ala Ala 
    50                  55                  60                  

Arg Glu Ala Phe Asp Arg Gly Pro Trp Ser Arg Met Ser Ala Ala Glu 
65                  70                  75                  80  

Arg Ser Arg Leu Met Tyr Lys Leu Ala Asp Leu Met Glu Glu Asn Lys 
                85                  90                  95      

Glu Glu Leu Ala Gln Leu Glu Thr Leu Asp Asn Gly Lys Pro Ile Arg 
            100                 105                 110         

Glu Thr Ile Asn Ala Asp Val Pro Leu Ala Ile Glu His Met Arg Tyr 
        115                 120                 125             

Tyr Ala Gly Trp Ser Thr Lys Ile Val Gly Gln Thr Ile Pro Val Asn 
    130                 135                 140                 

Gly Pro Tyr Phe Asn Tyr Thr Arg His Glu Pro Val Gly Val Val Gly 
145                 150                 155                 160 

Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Ala Met Trp Lys Leu 
                165                 170                 175     

Gly Ala Ala Leu Ala Thr Gly Cys Thr Val Val Leu Lys Pro Ala Glu 
            180                 185                 190         

Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Glu Leu Ile Glu Glu Ala 
        195                 200                 205             

Gly Phe Pro Ala Gly Val Val Asn Ile Val Pro Gly Phe Gly Glu Thr 
    210                 215                 220                 

Ala Gly Asp Ala Leu Val Lys His Pro Gln Val Asp Lys Ile Ala Phe 
225                 230                 235                 240 

Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Met Ala Asn Ala Ser Lys 
                245                 250                 255     

Ser Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile 
            260                 265                 270         

Ile Leu Pro Asp Ala Asp Phe Ser Lys Ala Ile Pro Gly Ala Leu Asn 
        275                 280                 285             

Gly Val Met Phe Asn Gln Gly Gln Val Cys Cys Ala Gly Ser Arg Val 
    290                 295                 300                 

Phe Ile Gln Lys Lys Gln Tyr Asp Asn Val Val Ala Asp Met Val Ser 
305                 310                 315                 320 

His Ala Lys Ser Ile Lys Gln Gly Phe Gly Leu Lys Ala Asp Thr Glu 
                325                 330                 335     

Met Gly Pro Leu Val Ser Ser Glu Gln Gln Asn Arg Val Leu Gly Tyr 
            340                 345                 350         

Ile Glu Lys Gly Leu Glu Glu Gly Ala Glu Leu Leu Thr Gly Gly Gln 
        355                 360                 365             

Lys Pro Ser Glu Gln Gly Tyr Phe Val Glu Pro Thr Ile Phe Ala Asn 
    370                 375                 380                 

Val Glu Asp Ser Met Thr Ile Ser Lys Glu Glu Ile Phe Gly Pro Val 
385                 390                 395                 400 

Ile Ala Ala Leu Pro Tyr Glu Asp Ile Asp Glu Leu Ile Glu Arg Ala 
                405                 410                 415     

Asn Asp Thr Asn Tyr Gly Leu Ala Ala Gly Val Trp Thr Arg Asp Val 
            420                 425                 430         

Thr Lys Ala His Tyr Ile Ala Asn Lys Leu Arg Ala Gly Thr Val Trp 
        435                 440                 445             

Val Asn Cys Tyr Asn Val Phe Asp Ala Ala Ser Pro Phe Gly Gly Tyr 
    450                 455                 460                 

Lys Glu Ser Gly Ile Gly Arg Glu Met Gly Ser Tyr Ala Leu Asp Asn 
465                 470                 475                 480 

Tyr Thr Glu Val Lys Ser Val Trp Ile Ala 
                485                 490 

<210>   616
<211>   481
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   616
Val Gln His Phe Leu Gln Gly Lys Lys Lys Met Phe Ile Asn Gly Gln 
                5                   10                  15      

Phe Val Glu Ser Ala Ser Gly Lys Thr Phe Asp Thr Pro Asn Pro Ala 
            20                  25                  30          

Thr Gly Glu Thr Leu Ala Thr Ile Tyr Glu Gly Asp Lys Gln Asp Ile 
        35                  40                  45              

Asp Arg Ala Val Gln Ala Ala Arg Lys Ala Phe Asp Glu Gly Pro Trp 
    50                  55                  60                  

Pro Arg Met Asn Pro Ala Asp Arg Ser Arg Leu Met Tyr Lys Leu Ala 
65                  70                  75                  80  

Asp Leu Met Glu Glu His Arg Glu Ala Leu Ala Gln Leu Glu Thr Leu 
                85                  90                  95      

Asp Asn Gly Lys Pro Ile Arg Glu Thr Ala Asn Ala Asp Ile Pro Leu 
            100                 105                 110         

Ala Ile Glu His Met Arg Tyr Tyr Ala Gly Trp Thr Thr Lys Ile Thr 
        115                 120                 125             

Gly Gln Thr Ile Pro Val Asn Gly Pro Tyr Phe Asn Tyr Thr Arg His 
    130                 135                 140                 

Glu Pro Val Gly Val Val Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu 
145                 150                 155                 160 

Leu Met Ala Met Trp Lys Met Gly Ala Ala Leu Ala Thr Gly Cys Thr 
                165                 170                 175     

Ile Ile Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu 
            180                 185                 190         

Ala Gln Leu Val Ser Glu Ala Gly Phe Pro Asp Gly Val Val Asn Ile 
        195                 200                 205             

Val Pro Gly Phe Gly Glu Thr Ala Gly Ala Ala Leu Val Asp His Pro 
    210                 215                 220                 

Leu Val Asp Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu 
225                 230                 235                 240 

Ile Met Ala Asn Ala Ser Lys Thr Leu Lys Arg Val Thr Leu Glu Leu 
                245                 250                 255     

Gly Gly Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala Asp Leu Ser Lys 
            260                 265                 270         

Ala Ile Pro Gly Ala Leu Asn Gly Val Met Phe Asn Gln Gly Gln Val 
        275                 280                 285             

Cys Cys Ala Gly Ser Arg Val Phe Ile Gln Lys Lys His Phe Asp Asn 
    290                 295                 300                 

Val Ile Ala Asp Met Ala Ser His Ala Gln Ser Ile Lys Gln Gly Phe 
305                 310                 315                 320 

Gly Leu Asn Lys Asp Thr Glu Met Gly Pro Leu Val Ser Asp Glu Gln 
                325                 330                 335     

Gln Ala Arg Val Leu Asn Tyr Ile Glu Lys Gly Leu Asp Glu Gly Ala 
            340                 345                 350         

Glu Ile Val Thr Gly Gly Lys Lys Pro Arg Glu Glu Gly Phe Phe Val 
        355                 360                 365             

Glu Pro Thr Ile Phe Ala Asp Val Arg Asp Glu Met Thr Ile Ala Lys 
    370                 375                 380                 

Glu Glu Ile Phe Gly Pro Val Ile Ala Ala Met Pro Tyr Glu Ser Leu 
385                 390                 395                 400 

Asp Glu Val Ile Ser Arg Ala Asn Cys Ser Glu Tyr Gly Leu Ala Ala 
                405                 410                 415     

Gly Val Trp Thr Glu Asn Val Ala Asn Ala His Tyr Ile Ala Asn Arg 
            420                 425                 430         

Leu Arg Ala Gly Thr Val Trp Val Asn Cys Tyr Asn Val Phe Asp Ala 
        435                 440                 445             

Ala Ser Pro Phe Gly Gly Tyr Lys Gln Ser Gly Ile Gly Arg Glu Met 
    450                 455                 460                 

Gly Ser Tyr Ala Leu Gln Asn Tyr Thr Glu Val Lys Ser Val Trp Ile 
465                 470                 475                 480 

Ala 
    

<210>   617
<211>   487
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   617
Leu His Glu Lys Val Glu Gln Phe Leu Gln Gly Thr Lys Lys Leu Tyr 
                5                   10                  15      

Val Asn Gly Thr Phe Val Glu Ser Val Ser Gly Lys Thr Phe Lys Thr 
            20                  25                  30          

Pro Asn Pro Ala Thr Gly Glu Thr Leu Ala Ile Val Ser Glu Ala Gly 
        35                  40                  45              

Arg Glu Asp Ile His Lys Ala Val Met Ala Ala Arg Gln Ala Phe Asp 
    50                  55                  60                  

Glu Gly Pro Trp Ser Cys Met Ser Gly Ala Glu Arg Ser Arg Leu Met 
65                  70                  75                  80  

Tyr Lys Leu Ala Asp Leu Met Glu Glu His Lys Asn Glu Leu Ala Gln 
                85                  90                  95      

Leu Glu Thr Leu Asp Asn Gly Lys Pro Ile Arg Glu Thr Leu Ala Ala 
            100                 105                 110         

Asp Ile Pro Leu Ala Ile Glu His Met Arg Tyr Tyr Ala Gly Trp Ala 
        115                 120                 125             

Thr Lys Ile Val Gly Gln Thr Ile Pro Val Ser Gly Glu Tyr Phe Asn 
    130                 135                 140                 

Tyr Thr Arg His Glu Ala Val Gly Val Val Gly Gln Ile Ile Pro Trp 
145                 150                 155                 160 

Asn Phe Pro Leu Leu Met Ala Met Trp Lys Met Gly Ala Ala Leu Ala 
                165                 170                 175     

Thr Gly Cys Thr Ile Val Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser 
            180                 185                 190         

Ala Leu Tyr Leu Ala Glu Leu Phe Glu Glu Ala Gly Phe Pro Lys Gly 
        195                 200                 205             

Val Val Asn Ile Val Pro Gly Phe Gly Glu Ile Ala Gly Gln Ala Leu 
    210                 215                 220                 

Val Asn His Pro Phe Val Asp Lys Ile Ala Phe Thr Gly Ser Thr Pro 
225                 230                 235                 240 

Val Gly Lys Gln Ile Met Arg Gln Ala Ser Glu Thr Leu Lys Arg Val 
                245                 250                 255     

Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala 
            260                 265                 270         

Asp Leu Ser Arg Ala Ile Pro Ala Ala Leu Ser Gly Val Met Phe Asn 
        275                 280                 285             

Gln Gly Gln Val Cys Cys Ala Gly Ser Arg Leu Phe Ile Pro Lys Lys 
    290                 295                 300                 

Met Tyr Asp Asn Val Met Ala Asp Leu Val Leu Tyr Ser Lys Asn Leu 
305                 310                 315                 320 

Thr Gln Gly Ala Gly Leu Asp Pro Lys Thr Thr Ile Gly Pro Leu Val 
                325                 330                 335     

Ser Glu Glu Gln Gln Gln Arg Val Met Gly Tyr Ile Glu Lys Gly Ile 
            340                 345                 350         

Glu Glu Gly Ala Glu Val Leu Cys Gly Gly Asn Lys Pro Phe Asp Lys 
        355                 360                 365             

Gly Tyr Phe Val Ala Pro Thr Val Phe Ala Asp Val Asn Asp Glu Met 
    370                 375                 380                 

Thr Ile Ala Lys Glu Glu Ile Phe Gly Pro Val Ile Ser Ala Leu Pro 
385                 390                 395                 400 

Phe Asn Asp Ile Asp Glu Val Ile Glu Arg Ala Asn Lys Ser Ser Phe 
                405                 410                 415     

Gly Leu Ala Ala Gly Val Trp Thr Glu Asn Ile Lys Asn Ala His Tyr 
            420                 425                 430         

Ile Ala Ser Lys Val Arg Ala Gly Thr Val Trp Val Asn Cys Tyr Asn 
        435                 440                 445             

Val Phe Asp Ala Ala Ser Pro Phe Gly Gly Tyr Lys Gln Ser Gly Leu 
    450                 455                 460                 

Gly Arg Glu Met Gly Ser Tyr Ala Leu Asp Asn Tyr Thr Glu Val Lys 
465                 470                 475                 480 

Ser Val Trp Val Asn Leu Asn 
                485         

<210>   618
<211>   487
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   618
Leu His Glu Lys Val Glu Lys Phe Leu Gln Gly Thr Lys Lys Leu Tyr 
                5                   10                  15      

Val Asn Gly Ser Phe Ile Glu Ser Ala Ser Gly Lys Thr Phe Lys Thr 
            20                  25                  30          

Pro Asn Pro Ala Thr Gly Glu Thr Leu Ala Val Val Ser Glu Ala Gly 
        35                  40                  45              

Arg Glu Asp Ile His Lys Ala Val Val Ala Ala Arg Met Ala Phe Asp 
    50                  55                  60                  

Glu Gly Pro Trp Ser Arg Met Ser Thr Ala Glu Arg Ser Arg Leu Met 
65                  70                  75                  80  

Tyr Lys Leu Ala Asp Leu Met Glu Glu His Lys Glu Glu Leu Ala Gln 
                85                  90                  95      

Leu Glu Thr Leu Asp Asn Gly Lys Pro Ile Arg Glu Thr Met Ala Ala 
            100                 105                 110         

Asp Ile Pro Leu Ala Ile Glu His Met Arg Tyr Tyr Ala Gly Trp Ala 
        115                 120                 125             

Thr Lys Ile Val Gly Gln Thr Ile Pro Val Ser Gly Asp Tyr Phe Asn 
    130                 135                 140                 

Tyr Thr Arg His Glu Ala Val Gly Val Val Gly Gln Ile Ile Pro Trp 
145                 150                 155                 160 

Asn Phe Pro Leu Leu Met Ala Met Trp Lys Met Gly Ala Ala Leu Ala 
                165                 170                 175     

Thr Gly Cys Thr Ile Val Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser 
            180                 185                 190         

Ala Leu Tyr Leu Ala Glu Leu Ile Glu Glu Ala Gly Phe Pro Lys Gly 
        195                 200                 205             

Val Ile Asn Ile Val Pro Gly Phe Gly Glu Ser Ala Gly Gln Ala Leu 
    210                 215                 220                 

Val Asn His Pro Leu Val Asp Lys Ile Ala Phe Thr Gly Ser Thr Pro 
225                 230                 235                 240 

Val Gly Lys Gln Ile Met Arg Gln Ala Ser Glu Thr Leu Lys Arg Val 
                245                 250                 255     

Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala 
            260                 265                 270         

Asp Leu Ser Arg Ala Ile Pro Gly Ala Leu Ser Gly Val Met Phe Asn 
        275                 280                 285             

Gln Gly Gln Val Cys Ser Ala Gly Ser Arg Leu Phe Val Pro Lys Lys 
    290                 295                 300                 

Met Tyr Asp Asn Val Met Ala Asp Leu Val Leu Tyr Ser Lys Lys Leu 
305                 310                 315                 320 

Asn Gln Gly Val Gly Leu Asn Pro Glu Thr Thr Ile Gly Pro Leu Val 
                325                 330                 335     

Ser Glu Glu Gln Gln Lys Arg Val Met Gly Tyr Ile Glu Lys Gly Ile 
            340                 345                 350         

Glu Glu Gly Ala Glu Val Leu Cys Gly Gly Ser Asn Pro Phe Asp Gln 
        355                 360                 365             

Gly Tyr Phe Val Ser Pro Thr Val Phe Ala Asp Val Asn Asp Glu Met 
    370                 375                 380                 

Thr Ile Ala Lys Glu Glu Ile Phe Gly Pro Val Ile Ser Ala Ile Pro 
385                 390                 395                 400 

Phe Asn Asp Ile Asp Glu Val Ile Glu Arg Ala Asn Lys Ser Gln Phe 
                405                 410                 415     

Gly Leu Ala Ala Gly Val Trp Thr Glu Asn Val Lys Thr Ala His Tyr 
            420                 425                 430         

Val Ala Ser Lys Val Arg Ala Gly Thr Val Trp Val Asn Cys Tyr Asn 
        435                 440                 445             

Val Phe Asp Ala Ala Ser Pro Phe Gly Gly Phe Lys Gln Ser Gly Leu 
    450                 455                 460                 

Gly Arg Glu Met Gly Ser Tyr Ala Leu Asn Asn Tyr Thr Glu Val Lys 
465                 470                 475                 480 

Ser Val Trp Leu Asn Leu Asn 
                485         

<210>   619
<211>   487
<212>   PRT
<213>   Bacillus cereus ATCC 10987

<400>   619
Leu His Glu Lys Val Glu Lys Phe Leu Gln Gly Thr Lys Lys Leu Tyr 
                5                   10                  15      

Val Asn Gly Ser Phe Ile Glu Ser Ala Ser Gly Lys Thr Phe Asn Thr 
            20                  25                  30          

Pro Asn Pro Ala Thr Gly Glu Thr Leu Ala Val Val Ser Glu Ala Gly 
        35                  40                  45              

Arg Glu Asp Ile His Lys Ala Val Val Ala Ala Arg Met Ala Phe Asp 
    50                  55                  60                  

Glu Gly Pro Trp Ser Arg Met Ser Thr Ala Glu Arg Ser Arg Leu Met 
65                  70                  75                  80  

Tyr Lys Leu Ala Asp Leu Met Glu Glu His Lys Glu Glu Leu Ala Gln 
                85                  90                  95      

Leu Glu Thr Leu Asp Asn Gly Lys Pro Ile Arg Glu Thr Met Ala Ala 
            100                 105                 110         

Asp Ile Pro Leu Ala Ile Glu His Met Arg Tyr Tyr Ala Gly Trp Ala 
        115                 120                 125             

Thr Lys Ile Val Gly Gln Thr Ile Pro Val Ser Gly Asp Tyr Phe Asn 
    130                 135                 140                 

Tyr Thr Arg His Glu Ala Val Gly Val Val Gly Gln Ile Ile Pro Trp 
145                 150                 155                 160 

Asn Phe Pro Leu Leu Met Ala Met Trp Lys Met Gly Ala Ala Leu Ala 
                165                 170                 175     

Thr Gly Cys Thr Ile Val Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser 
            180                 185                 190         

Ala Leu Tyr Leu Ala Glu Leu Ile Glu Glu Ala Gly Phe Pro Lys Gly 
        195                 200                 205             

Val Ile Asn Ile Val Pro Gly Phe Gly Glu Ser Ala Gly Gln Ala Leu 
    210                 215                 220                 

Val Asn His Pro Leu Val Asp Lys Ile Ala Phe Thr Gly Ser Thr Pro 
225                 230                 235                 240 

Val Gly Lys Gln Ile Met Arg Gln Ala Ser Glu Thr Leu Lys Arg Val 
                245                 250                 255     

Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala 
            260                 265                 270         

Asp Leu Ser Arg Ala Ile Pro Gly Ala Leu Ser Gly Val Met Phe Asn 
        275                 280                 285             

Gln Gly Gln Val Cys Ser Ala Gly Ser Arg Leu Phe Val Pro Lys Lys 
    290                 295                 300                 

Met Tyr Asp Asn Val Met Ala Asp Leu Val Leu Tyr Ser Lys Lys Leu 
305                 310                 315                 320 

Asn Gln Gly Ala Gly Leu Ser Pro Glu Thr Thr Ile Gly Pro Leu Val 
                325                 330                 335     

Ser Glu Glu Gln Gln Lys Arg Val Met Gly Tyr Ile Glu Lys Gly Ile 
            340                 345                 350         

Glu Glu Gly Ala Glu Val Leu Cys Gly Gly Ser Asn Pro Phe Asp Arg 
        355                 360                 365             

Gly Tyr Phe Val Ser Pro Thr Val Phe Ala Asp Val Asn Asp Glu Met 
    370                 375                 380                 

Thr Ile Ala Lys Glu Glu Ile Phe Gly Pro Val Ile Ser Ala Ile Pro 
385                 390                 395                 400 

Phe Asn Asp Ile Asp Glu Val Ile Glu Arg Ala Asn Lys Ser Gln Phe 
                405                 410                 415     

Gly Leu Ala Ala Gly Val Trp Thr Glu Asn Val Lys Thr Ala His Tyr 
            420                 425                 430         

Val Ala Ser Lys Val Arg Ala Gly Thr Val Trp Val Asn Cys Tyr Asn 
        435                 440                 445             

Val Phe Asp Ala Ala Ser Pro Phe Gly Gly Phe Lys Gln Ser Gly Leu 
    450                 455                 460                 

Gly Arg Glu Met Gly Ser Tyr Ala Leu Asn Asn Tyr Thr Glu Val Lys 
465                 470                 475                 480 

Ser Val Trp Leu Asn Leu Asn 
                485         

<210>   620
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   620
Met Ala Val Gln Glu Val Asn Ala Ser Ala Leu His Pro Asp Val Val 
                5                   10                  15      

Glu Phe Leu Lys Gly Pro Lys Gly Leu Phe Ile Asp Gly Glu Phe Val 
            20                  25                  30          

Pro Ser Ile Ser Gly Lys Thr Phe Lys Ser Ile Asn Pro Ala Thr Glu 
        35                  40                  45              

Glu Val Leu Val Glu Val Ala Glu Ala Glu Ala Pro Asp Ile Asp Arg 
    50                  55                  60                  

Ala Val Lys Ala Ala Arg Arg Ala Phe Glu Ser Gly Pro Trp Ser Arg 
65                  70                  75                  80  

Met Ser Ala Ala Glu Arg Ser Arg Leu Leu Tyr Arg Leu Ala Asp Leu 
                85                  90                  95      

Met Glu Glu His Lys Leu Gln Leu Ala Gln Leu Glu Thr Leu Asp Asn 
            100                 105                 110         

Gly Lys Pro Ile Arg Glu Ser Leu Asn Ala Asp Leu Pro Leu Ala Ile 
        115                 120                 125             

Glu His Ile Arg Tyr Tyr Ala Gly Trp Pro Thr Lys Val Val Gly Gln 
    130                 135                 140                 

Thr Ile Pro Val Ala Gly Lys Tyr Phe Asn Tyr Thr Arg His Glu Pro 
145                 150                 155                 160 

Val Gly Val Val Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
                165                 170                 175     

Ala Cys Trp Lys Ile Gly Ala Ala Leu Ala Met Gly Cys Thr Val Val 
            180                 185                 190         

Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Lys 
        195                 200                 205             

Leu Ile Gln Glu Ala Gly Phe Pro Pro Gly Val Val Asn Val Val Pro 
    210                 215                 220                 

Gly Phe Gly Glu Thr Ala Gly Gln Ala Leu Val Glu His Pro Asp Val 
225                 230                 235                 240 

Asn Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Met 
                245                 250                 255     

Arg Asn Ala Ala Ala Thr Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         

Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala Asp Met Ser Arg Ala Ile 
        275                 280                 285             

Pro Gly Ala Phe Met Gly Ile Met Phe Asn Gln Gly Gln Val Cys Cys 
    290                 295                 300                 

Ala Gly Ser Arg Leu Phe Val Gln Lys Lys Ala Tyr Asp Asn Val Val 
305                 310                 315                 320 

Ala Asp Leu Val Ser Leu Ala Lys Lys Ile Arg Gln Gly Pro Gly Leu 
                325                 330                 335     

Asp Gln Gly Thr Glu Met Gly Pro Leu Val Ser Asp Glu Gln Glu Lys 
            340                 345                 350         

Arg Val Leu Gly Tyr Ile Glu Lys Gly Val Glu Glu Gly Ala Glu Val 
        355                 360                 365             

Leu Val Gly Gly Gly Lys Ala Thr Asp Arg Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 

Thr Ile Phe Ala Asn Val Arg Asp Asp Met Thr Ile Ala Arg Glu Glu 
385                 390                 395                 400 

Ile Phe Gly Pro Val Val Ala Ala Met Pro Phe Glu Asp Leu Asp Glu 
                405                 410                 415     

Val Ile Ala Arg Ala Asn Asp Thr Glu Tyr Gly Leu Ala Ala Gly Val 
            420                 425                 430         

Trp Thr Glu Asn Ile Arg Asn Ala His Tyr Ile Ala Ser Lys Leu Lys 
        435                 440                 445             

Ala Gly Thr Val Trp Val Asn Cys Tyr Asn Val Phe Asp Ala Ala Ala 
    450                 455                 460                 

Pro Phe Gly Gly Tyr Lys Gln Ser Gly Ile Gly Arg Glu Met Gly Ser 
465                 470                 475                 480 

Tyr Ala Leu Asn Asn Tyr Thr Glu Val Lys Asp Val Trp Ile Ser Leu 
                485                 490                 495     

Ser 
    

<210>   621
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   621
Met Ala Val Gln Glu Val Asn Ala Ser Ala Leu His Pro Glu Val Val 
                5                   10                  15      

Glu Phe Leu Lys Gly Pro Lys Gly Leu Phe Ile Asp Gly Glu Phe Val 
            20                  25                  30          

Pro Ser Leu Ser Gly Lys Thr Phe Lys Ser Ile Asn Pro Ala Thr Glu 
        35                  40                  45              

Glu Val Leu Val Glu Val Ala Glu Ala Glu Ala Pro Asp Ile Asp Arg 
    50                  55                  60                  

Ala Val Lys Ala Ala Arg Arg Ala Phe Glu Ser Gly Pro Trp Ser Arg 
65                  70                  75                  80  

Met Ser Ala Ala Glu Arg Ser Arg Leu Leu Tyr Arg Leu Ala Asp Leu 
                85                  90                  95      

Met Glu Glu His Lys Leu Gln Leu Ala Gln Leu Glu Thr Leu Asp Asn 
            100                 105                 110         

Gly Lys Pro Ile Arg Glu Ser Leu Asn Ala Asp Leu Pro Leu Ala Ile 
        115                 120                 125             

Glu His Ile Arg Tyr Tyr Ala Gly Trp Pro Thr Lys Val Val Gly Gln 
    130                 135                 140                 

Thr Ile Pro Val Ala Gly Lys Tyr Phe Asn Tyr Thr Arg His Glu Pro 
145                 150                 155                 160 

Val Gly Val Val Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
                165                 170                 175     

Ala Cys Trp Lys Ile Gly Ala Ala Leu Ala Met Gly Cys Thr Val Val 
            180                 185                 190         

Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Lys 
        195                 200                 205             

Leu Ile Gln Glu Ala Gly Phe Pro Pro Gly Val Val Asn Val Val Pro 
    210                 215                 220                 

Gly Phe Gly Glu Thr Ala Gly Gln Ala Leu Val Glu His Pro Asp Val 
225                 230                 235                 240 

Asn Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Met 
                245                 250                 255     

Arg Asn Ala Ala Ala Thr Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         

Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala Asp Met Ser Arg Ala Ile 
        275                 280                 285             

Pro Gly Ala Phe Met Gly Ile Met Phe Asn Gln Gly Gln Val Cys Cys 
    290                 295                 300                 

Ala Gly Ser Arg Leu Phe Val Gln Lys Lys Ala Tyr Asp Asn Val Val 
305                 310                 315                 320 

Ala Asp Leu Val Ser Leu Ala Lys Lys Ile Arg Gln Gly Pro Gly Leu 
                325                 330                 335     

Asp Gln Gly Thr Glu Met Gly Pro Leu Val Ser Asp Glu Gln Glu Lys 
            340                 345                 350         

Arg Val Leu Gly Tyr Ile Glu Lys Gly Val Glu Glu Gly Ala Glu Val 
        355                 360                 365             

Leu Val Gly Gly Gly Lys Ala Thr Asp Arg Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 

Thr Ile Phe Ala Asn Val Arg Asp Asp Met Thr Ile Ala Arg Glu Glu 
385                 390                 395                 400 

Ile Phe Gly Pro Val Val Ala Ala Met Pro Phe Glu Asp Leu Asp Glu 
                405                 410                 415     

Val Ile Ala Arg Ala Asn Asp Thr Glu Tyr Gly Leu Ala Ala Gly Val 
            420                 425                 430         

Trp Thr Glu Asn Ile Arg Asn Ala His Tyr Ile Ala Ser Lys Leu Lys 
        435                 440                 445             

Ala Gly Thr Val Trp Val Asn Cys Tyr Asn Val Phe Asp Ala Ala Ala 
    450                 455                 460                 

Pro Phe Gly Gly Tyr Lys Gln Ser Gly Ile Gly Arg Glu Met Gly Ser 
465                 470                 475                 480 

Tyr Ala Leu Asn Asn Tyr Thr Glu Val Lys Asp Val Trp Ile Ser Leu 
                485                 490                 495     

Ser 
    

<210>   622
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   622
Met Ala Val Gln Glu Val Asn Ala Ser Ala Leu His Pro Asp Val Val 
                5                   10                  15      

Glu Phe Leu Lys Gly Pro Lys Gly Leu Phe Ile Asp Gly Glu Phe Val 
            20                  25                  30          

Pro Ser Leu Ser Gly Lys Thr Phe Lys Ser Ile Asn Pro Ala Thr Glu 
        35                  40                  45              

Glu Val Leu Val Glu Val Ala Glu Ala Glu Ala Pro Asp Ile Asp Arg 
    50                  55                  60                  

Ala Val Lys Ala Ala Arg Arg Ala Phe Glu Ser Gly Pro Trp Ser Arg 
65                  70                  75                  80  

Met Ser Ala Ala Glu Arg Ser Arg Leu Leu Tyr Arg Leu Ala Asp Leu 
                85                  90                  95      

Met Glu Glu His Lys Leu Gln Leu Ala Gln Leu Glu Thr Leu Asp Asn 
            100                 105                 110         

Gly Lys Pro Ile Arg Glu Ser Leu Asn Ala Asp Leu Pro Leu Ala Ile 
        115                 120                 125             

Glu His Ile Arg Tyr Tyr Ala Gly Trp Pro Thr Lys Val Val Gly Gln 
    130                 135                 140                 

Thr Ile Pro Val Ala Gly Lys Tyr Phe Asn Tyr Thr Arg His Glu Pro 
145                 150                 155                 160 

Val Gly Val Val Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
                165                 170                 175     

Ala Cys Trp Lys Ile Gly Ala Ala Leu Ala Met Gly Cys Thr Val Val 
            180                 185                 190         

Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Lys 
        195                 200                 205             

Leu Ile Gln Glu Ala Gly Phe Pro Pro Gly Val Val Asn Val Val Pro 
    210                 215                 220                 

Gly Phe Gly Glu Thr Ala Gly Gln Ala Leu Val Glu His Pro Asp Val 
225                 230                 235                 240 

Asn Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Met 
                245                 250                 255     

Arg Asn Ala Ala Ala Thr Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         

Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala Asp Met Ser Arg Ala Ile 
        275                 280                 285             

Pro Gly Ala Phe Met Gly Ile Met Phe Asn Gln Gly Gln Val Cys Cys 
    290                 295                 300                 

Ala Gly Ser Arg Leu Phe Val Gln Lys Lys Ala Tyr Asp Asn Val Val 
305                 310                 315                 320 

Ala Asp Leu Val Ser Leu Ala Lys Lys Ile Arg Gln Gly Pro Gly Leu 
                325                 330                 335     

Asp Gln Gly Thr Glu Met Gly Pro Leu Val Ser Asp Glu Gln Glu Lys 
            340                 345                 350         

Arg Val Leu Gly Tyr Ile Glu Lys Gly Val Glu Glu Gly Ala Glu Val 
        355                 360                 365             

Leu Val Gly Gly Gly Lys Ala Thr Asp Arg Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 

Thr Ile Phe Ala Asn Val Arg Asp Asp Met Thr Ile Ala Arg Glu Glu 
385                 390                 395                 400 

Ile Phe Gly Pro Val Val Ala Ala Met Pro Phe Glu Asp Leu Asp Glu 
                405                 410                 415     

Val Ile Ala Arg Ala Asn Glu Thr Glu Tyr Gly Leu Ala Ala Gly Val 
            420                 425                 430         

Trp Thr Glu Asn Ile Arg Asn Ala His Tyr Ile Ala Ser Lys Leu Lys 
        435                 440                 445             

Ala Gly Thr Val Trp Val Asn Cys Tyr Asn Val Phe Asp Ala Ala Ala 
    450                 455                 460                 

Pro Phe Gly Gly Tyr Lys Gln Ser Gly Ile Gly Arg Glu Met Gly Ser 
465                 470                 475                 480 

Tyr Ala Leu Asn Asn Tyr Thr Glu Val Lys Asp Val Trp Ile Ser Leu 
                485                 490                 495     

Ser 
    

<210>   623
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   623
Met Ala Val Gln Glu Val Asn Ala Ser Ala Leu His Pro Asp Val Val 
                5                   10                  15      

Glu Phe Leu Lys Gly Pro Lys Gly Leu Phe Ile Asp Gly Glu Phe Val 
            20                  25                  30          

Pro Ser Leu Ser Gly Lys Thr Phe Lys Ser Ile Asn Pro Ala Thr Glu 
        35                  40                  45              

Glu Val Leu Val Glu Val Ala Glu Ala Glu Ala Pro Asp Ile Asp Arg 
    50                  55                  60                  

Ala Val Lys Ala Ala Arg Arg Ala Phe Glu Ser Gly Pro Trp Ser Arg 
65                  70                  75                  80  

Met Ser Ala Ala Glu Arg Ser Arg Leu Leu Tyr Arg Leu Ala Asp Leu 
                85                  90                  95      

Met Glu Glu His Lys Leu Gln Leu Ala Gln Leu Glu Thr Leu Asp Asn 
            100                 105                 110         

Gly Lys Pro Ile Arg Glu Ser Leu Asn Ala Asp Leu Pro Leu Ala Ile 
        115                 120                 125             

Glu His Ile Arg Tyr Tyr Ala Gly Trp Pro Thr Lys Val Val Gly Gln 
    130                 135                 140                 

Thr Ile Pro Val Ala Gly Lys Tyr Phe Asn Tyr Thr Arg His Glu Pro 
145                 150                 155                 160 

Val Gly Val Val Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
                165                 170                 175     

Ala Cys Trp Lys Ile Gly Ala Ala Leu Ala Met Gly Cys Thr Val Val 
            180                 185                 190         

Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Lys 
        195                 200                 205             

Leu Ile Gln Glu Ala Gly Phe Pro Pro Gly Val Val Asn Val Val Pro 
    210                 215                 220                 

Gly Phe Gly Glu Thr Ala Gly Gln Ala Leu Val Glu His Pro Asp Val 
225                 230                 235                 240 

Asn Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Met 
                245                 250                 255     

Arg Asn Ala Ala Ala Thr Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         

Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala Asp Met Ser Arg Ala Ile 
        275                 280                 285             

Pro Gly Ala Phe Met Gly Ile Met Phe Asn Gln Gly Gln Val Cys Cys 
    290                 295                 300                 

Ala Gly Ser Arg Leu Phe Val Gln Lys Lys Ala Tyr Asp Asn Val Val 
305                 310                 315                 320 

Ala Asp Leu Val Ser Leu Ala Lys Lys Ile Arg Gln Gly Pro Gly Leu 
                325                 330                 335     

Asp Gln Gly Thr Glu Met Gly Pro Leu Val Ser Asp Glu Gln Glu Lys 
            340                 345                 350         

Arg Val Leu Gly Tyr Ile Glu Lys Gly Val Glu Glu Gly Ala Glu Val 
        355                 360                 365             

Leu Val Gly Gly Gly Lys Ala Thr Asp Arg Gly Tyr Phe Val Asn Pro 
    370                 375                 380                 

Thr Ile Phe Ala Asn Val Arg Asp Asp Met Thr Ile Ala Arg Glu Glu 
385                 390                 395                 400 

Ile Phe Gly Pro Val Val Ala Ala Met Pro Phe Glu Asp Leu Asp Glu 
                405                 410                 415     

Val Ile Ala Arg Ala Asn Asp Thr Glu Tyr Gly Leu Ala Ala Gly Val 
            420                 425                 430         

Trp Thr Glu Asn Ile Arg Asn Ala His Tyr Ile Ala Ser Lys Leu Lys 
        435                 440                 445             

Ala Gly Thr Val Trp Val Asn Cys Tyr Asn Val Phe Asp Ala Ala Ala 
    450                 455                 460                 

Pro Phe Gly Gly Tyr Lys Gln Ser Gly Ile Gly Arg Glu Met Gly Ser 
465                 470                 475                 480 

Tyr Ala Leu Asn Asn Tyr Thr Glu Val Lys Asp Val Trp Ile Ser Leu 
                485                 490                 495     

Ser 
    

<210>   624
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   624
Met Ala Val Gln Glu Val Asn Ala Ser Ala Leu His Pro Asp Val Val 
                5                   10                  15      

Glu Phe Leu Lys Gly Pro Lys Gly Leu Phe Ile Asp Gly Glu Phe Val 
            20                  25                  30          

Pro Ser Leu Ser Gly Lys Thr Phe Lys Ser Ile Asn Pro Ala Thr Glu 
        35                  40                  45              

Glu Val Leu Val Glu Val Ala Glu Ala Glu Ala Pro Asp Ile Asp Arg 
    50                  55                  60                  

Ala Val Lys Ala Ala Arg Arg Ala Phe Glu Ser Gly Pro Trp Ser Arg 
65                  70                  75                  80  

Met Ser Ala Ala Glu Arg Ser Arg Leu Leu Tyr Arg Leu Ala Asp Leu 
                85                  90                  95      

Met Glu Glu His Lys Leu Gln Leu Ala Gln Leu Glu Thr Leu Asp Asn 
            100                 105                 110         

Gly Lys Pro Ile Arg Glu Ser Ile Asn Ala Asp Leu Pro Leu Ala Ile 
        115                 120                 125             

Glu His Ile Arg Tyr Tyr Ala Gly Trp Pro Thr Lys Val Val Gly Gln 
    130                 135                 140                 

Thr Ile Pro Val Ala Gly Lys Tyr Phe Asn Tyr Thr Arg His Glu Pro 
145                 150                 155                 160 

Val Gly Val Val Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
                165                 170                 175     

Ala Cys Trp Lys Ile Gly Ala Ala Leu Ala Met Gly Cys Thr Val Val 
            180                 185                 190         

Leu Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Lys 
        195                 200                 205             

Leu Ile Gln Glu Ala Gly Phe Pro Pro Gly Val Val Asn Val Val Pro 
    210                 215                 220                 

Gly Phe Gly Glu Thr Ala Gly Gln Ala Leu Val Glu His Pro Asp Val 
225                 230                 235                 240 

Asn Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Met 
                245                 250                 255     

Arg Asn Ala Ala Ala Thr Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         

Lys Ser Pro Asn Ile Ile Leu Pro Asp Ala Asp Met Ser Arg Ala Ile 
        275                 280                 285             

Pro Gly Ala Phe Met Gly Ile Met Phe Asn Gln Gly Gln Val Cys Cys 
    290                 295                 300                 

Ala Gly Ser Arg Leu Phe Val Gln Lys Lys Ala Tyr Asp Asn Val Val 
305                 310                 315                 320 

Ala Asp Leu Val Ser Leu Ala Lys Lys Ile Arg Gln Gly Pro Gly Leu 
                325                 330                 335     

Asp Gln Gly Thr Glu Met Gly Pro Leu Val Ser Asp Glu Gln Glu Lys 
            340                 345                 350         

Arg Val Leu Gly Tyr Ile Glu Lys Gly Val Glu Glu Gly Ala Glu Val 
        355                 360                 365             

Leu Val Gly Gly Gly Lys Ala Thr Asp Arg Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 

Thr Ile Phe Ala Asn Val Arg Asp Asp Met Thr Ile Ala Arg Glu Glu 
385                 390                 395                 400 

Ile Phe Gly Pro Val Val Ala Ala Met Pro Phe Glu Asp Leu Asp Glu 
                405                 410                 415     

Val Ile Ala Arg Ala Asn Asp Thr Glu Tyr Gly Leu Ala Ala Gly Val 
            420                 425                 430         

Trp Thr Glu Asn Ile Arg Asn Ala His Tyr Ile Ala Ser Lys Leu Lys 
        435                 440                 445             

Ala Gly Thr Val Trp Val Asn Cys Tyr Asn Val Phe Asp Ala Ala Ala 
    450                 455                 460                 

Pro Phe Gly Gly Tyr Lys Gln Ser Gly Ile Gly Arg Glu Met Gly Ser 
465                 470                 475                 480 

Tyr Ala Leu Asn Asn Tyr Thr Glu Val Lys Asp Val Trp Ile Ser Leu 
                485                 490                 495     

Ser 
    

<210>   625
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   625
gtggcagttc aagaagtgaa tgcgagcgct ctgcatccgg atgtcgtcga gtttctcaag       60

ggtcccaagg gcctgttcat tgacggcgaa ttcgttccct caatttccgg caaaacgttc      120

aagtctatca accctgcgac agaagaagtc ctggtggaag tcgcggaggc ggaagctccc      180

gacattgacc gcgcggtcaa agccgctcgc cgcgcctttg agtccggccc gtggtcgcgc      240

atgagcgccg cggagcggtc ccggcttctc tataggctgg cggatctcat ggaagaacat      300

aagctgcagc tcgctcagct cgaaaccctc gacaacggca aacccattcg cgaatccctg      360

aacgcagacc tgccgcttgc catcgaacac attcgctact acgccggctg gcccaccaag      420

gtcgtggggc aaaccattcc ggtagcggga aaatacttca actacacgcg acacgagccc      480

gtcggcgtcg tgggccagat catcccgtgg aacttcccgc tcctcatggc gtgctggaag      540

attggcgccg cgctggccat gggctgcacg gtggtgctca agccggcgga gcagacgccg      600

ctctccgcgc tctacctggc caaactgatc caagaggctg gcttcccgcc gggcgtcgtc      660

aatgtcgtgc cgggcttcgg cgagaccgcc ggacaggcac tggtggagca cccggacgtc      720

aacaagattg cgttcaccgg atcgacggag gtcggcaagc tcatcatgcg caacgccgcg      780

gcgaccttga agcgcgtcac gctcgagctc ggcggcaagt ccccgaacat cattctcccc      840

gatgccgaca tgagccgagc catccccggc gcgttcatgg gcatcatgtt caaccagggc      900

caggtgtgct gcgccggatc gcgcctgttc gtgcagaaga aagcgtacga caacgtggtg      960

gccgatctcg tctccctcgc gaagaagatc cgccaaggcc cgggcttgga tcaaggcacg     1020

gagatggggc cgctcgtgtc cgatgaacag gagaagcgcg tgctgggcta catcgagaag     1080

ggcgtggaag agggcgccga ggtcctcgtc ggcggcggca aggccacgga tcgcggatac     1140

ttcgtgcagc cgaccatctt cgccaatgtc cgggacgaca tgaccatcgc gcgcgaggag     1200

atcttcggac cggtggtcgc ggcgatgccg tttgaagatt tggacgaagt cattgcgcgc     1260

gcgaacgaca cggagtacgg cctggcggcc ggtgtgtgga cggagaacat ccggaatgcc     1320

cactatatcg ccagcaagct gaaggccggc actgtttggg tcaactgcta caacgtgttt     1380

gacgcggcgg ctcccttcgg tggatacaag cagtccggta tcgggcgcga aatgggctcg     1440

tacgcgttga acaactacac cgaggtcaag gatgtgtgga tcagcctgag ctga           1494


<210>   626
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   626
gtggcagttc aagaagtgaa tgcgagcgct ctgcatccgg aagtcgtcga gtttctcaag       60

ggtcccaagg gcctgttcat tgacggcgaa ttcgttccct cactctccgg caaaacgttc      120

aagtctatca accctgcgac agaagaagtc ctggtggaag tcgcggaggc ggaagctccc      180

gacattgacc gcgcggtcaa agccgctcgc cgcgcctttg agtccggccc gtggtcgcgc      240

atgagcgccg cggagcggtc ccggcttctc tataggctgg cggatctcat ggaagaacat      300

aagctgcagc tcgctcagct cgaaaccctc gacaacggca aacccattcg cgaatccctg      360

aacgcagacc tgccgcttgc catcgaacac attcgctact acgccggctg gcccaccaag      420

gtcgtggggc aaaccattcc ggtagcggga aaatacttca actacacgcg acacgagccc      480

gtcggcgtcg tgggccagat catcccgtgg aacttcccgc tcctcatggc gtgctggaag      540

attggcgccg cgctggccat gggctgcacg gtggtgctca agccggcgga gcagacgccg      600

ctctccgcgc tctacctggc caaactgatc caagaggctg gcttcccgcc gggcgtcgtc      660

aatgtcgtgc cgggcttcgg cgagaccgcc ggacaggcac tggtggagca cccggacgtc      720

aacaagattg cgttcaccgg atcgacggag gtcggcaagc tcatcatgcg caacgccgcg      780

gcgaccttga agcgcgtcac gctcgagctc ggcggcaagt ccccgaacat cattctcccc      840

gatgccgaca tgagccgagc catccccggc gcgttcatgg gcatcatgtt caaccagggc      900

caggtgtgct gcgccggatc gcgcctgttc gtgcagaaga aagcgtacga caacgtggtg      960

gccgatctcg tctccctcgc gaagaagatc cgccaaggcc cgggcttgga tcaaggcacg     1020

gagatggggc cgctcgtgtc cgatgaacag gagaagcgcg tgctgggcta catcgagaag     1080

ggcgtggaag agggcgccga ggtcctcgtc ggcggcggca aggccacgga tcgcggatac     1140

ttcgtgcagc cgaccatctt cgccaatgtc cgggacgaca tgaccatcgc gcgcgaggag     1200

atcttcggac cggtggtcgc ggcgatgccg tttgaagatt tggacgaagt cattgcgcgc     1260

gcgaacgaca cggagtacgg cctggcggcc ggtgtgtgga cggagaacat ccggaatgcc     1320

cactatatcg ccagcaagct gaaggccggc actgtttggg tcaactgcta caacgtgttt     1380

gacgcggcgg ctcccttcgg tggatacaag cagtccggta tcgggcgcga aatgggctcg     1440

tacgcgttga acaactacac cgaggtcaag gatgtgtgga tcagcctgag ctga           1494


<210>   627
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   627
gtggcagttc aagaagtgaa tgcgagcgct ctgcatccgg atgtcgtcga gtttctcaag       60

ggtcccaagg gcctgttcat tgacggcgaa ttcgttccct cactctccgg caaaacgttc      120

aagtctatca accctgcgac agaagaagtc ctggtggaag tcgcggaggc ggaagctccc      180

gacattgacc gcgcggtcaa agccgctcgc cgcgcctttg agtccggccc gtggtcgcgc      240

atgagcgccg cggagcggtc ccggcttctc tataggctgg cggatctcat ggaagaacat      300

aagctgcagc tcgctcagct cgaaaccctc gacaacggca aacccattcg cgaatccctg      360

aacgcagacc tgccgcttgc catcgaacac attcgctact acgccggctg gcccaccaag      420

gtcgtggggc aaaccattcc ggtagcggga aaatacttca actacacgcg acacgagccc      480

gtcggcgtcg tgggccagat catcccgtgg aacttcccgc tcctcatggc gtgctggaag      540

attggcgccg cgctggccat gggctgcacg gtggtgctca agccggcgga gcagacgccg      600

ctctccgcgc tctacctggc caaactgatc caagaggctg gcttcccgcc gggcgtcgtc      660

aatgtcgtgc cgggcttcgg cgagaccgcc ggacaggcac tggtggagca cccggacgtc      720

aacaagattg cgttcaccgg atcgacggag gtcggcaagc tcatcatgcg caacgccgcg      780

gcgaccttga agcgcgtcac gctcgagctc ggcggcaagt ccccgaacat cattctcccc      840

gatgccgaca tgagccgagc catccccggc gcgttcatgg gcatcatgtt caaccagggc      900

caggtgtgct gcgccggatc gcgcctgttc gtgcagaaga aagcgtacga caacgtggtg      960

gccgatctcg tctccctcgc gaagaagatc cgccaaggcc cgggcttgga tcaaggcacg     1020

gagatggggc cgctcgtgtc cgatgaacag gagaagcgcg tgctgggcta catcgagaag     1080

ggcgtggaag agggcgccga ggtcctcgtc ggcggcggca aggccacgga tcgcggatac     1140

ttcgtgcagc cgaccatctt cgccaatgtc cgggacgaca tgaccatcgc gcgcgaggag     1200

atcttcggac cggtggtcgc ggcgatgccg tttgaagatt tggacgaagt cattgcgcgc     1260

gcgaacgaaa cggagtacgg cctggcggcc ggtgtgtgga cggagaacat ccggaatgcc     1320

cactatatcg ccagcaagct gaaggccggc actgtttggg tcaactgcta caacgtgttt     1380

gacgcggcgg ctcccttcgg tggatacaag cagtccggta tcgggcgcga aatgggctcg     1440

tacgcgttga acaactacac cgaggtcaag gatgtgtgga tcagcctgag ctga           1494


<210>   628
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   628
gtggcagttc aagaagtgaa tgcgagcgct ctgcatccgg atgtcgtcga gtttctcaag       60

ggtcccaagg gcctgttcat tgacggcgaa ttcgttccct cactctccgg caaaacgttc      120

aagtctatca accctgcgac agaagaagtc ctggtggaag tcgcggaggc ggaagctccc      180

gacattgacc gcgcggtcaa agccgctcgc cgcgcctttg agtccggccc gtggtcgcgc      240

atgagcgccg cggagcggtc ccggcttctc tataggctgg cggatctcat ggaagaacat      300

aagctgcagc tcgctcagct cgaaaccctc gacaacggca aacccattcg cgaatccctg      360

aacgcagacc tgccgcttgc catcgaacac attcgctact acgccggctg gcccaccaag      420

gtcgtggggc aaaccattcc ggtagcggga aaatacttca actacacgcg acacgagccc      480

gtcggcgtcg tgggccagat catcccgtgg aacttcccgc tcctcatggc gtgctggaag      540

attggcgccg cgctggccat gggctgcacg gtggtgctca agccggcgga gcagacgccg      600

ctctccgcgc tctacctggc caaactgatc caagaggctg gcttcccgcc gggcgtcgtc      660

aatgtcgtgc cgggcttcgg cgagaccgcc ggacaggcac tggtggagca cccggacgtc      720

aacaagattg cgttcaccgg atcgacggag gtcggcaagc tcatcatgcg caacgccgcg      780

gcgaccttga agcgcgtcac gctcgagctc ggcggcaagt ccccgaacat cattctcccc      840

gatgccgaca tgagccgagc catccccggc gcgttcatgg gcatcatgtt caaccagggc      900

caggtgtgct gcgccggatc gcgcctgttc gtgcagaaga aagcgtacga caacgtggtg      960

gccgatctcg tctccctcgc gaagaagatc cgccaaggcc cgggcttgga tcaaggcacg     1020

gagatggggc cgctcgtgtc cgatgaacag gagaagcgcg tgctgggcta catcgagaag     1080

ggcgtggaag agggcgccga ggtcctcgtc ggcggcggca aggccacgga tcgcggatac     1140

ttcgtgaatc cgaccatctt cgccaatgtc cgggacgaca tgaccatcgc gcgcgaggag     1200

atcttcggac cggtggtcgc ggcgatgccg tttgaagatt tggacgaagt cattgcgcgc     1260

gcgaacgaca cggagtacgg cctggcggcc ggtgtgtgga cggagaacat ccggaatgcc     1320

cactatatcg ccagcaagct gaaggccggc actgtttggg tcaactgcta caacgtgttt     1380

gacgcggcgg ctcccttcgg tggatacaag cagtccggta tcgggcgcga aatgggctcg     1440

tacgcgttga acaactacac cgaggtcaag gatgtgtgga tcagcctgag ctga           1494


<210>   629
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   629
gtggcagttc aagaagtgaa tgcgagcgct ctgcatccgg atgtcgtcga gtttctcaag       60

ggtcccaagg gcctgttcat tgacggcgaa ttcgttccct cactctccgg caaaacgttc      120

aagtctatca accctgcgac agaagaagtc ctggtggaag tcgcggaggc ggaagctccc      180

gacattgacc gcgcggtcaa agccgctcgc cgcgcctttg agtccggccc gtggtcgcgc      240

atgagcgccg cggagcggtc ccggcttctc tataggctgg cggatctcat ggaagaacat      300

aagctgcagc tcgctcagct cgaaaccctc gacaacggca aacccattcg cgaatccatt      360

aacgcagacc tgccgcttgc catcgaacac attcgctact acgccggctg gcccaccaag      420

gtcgtggggc aaaccattcc ggtagcggga aaatacttca actacacgcg acacgagccc      480

gtcggcgtcg tgggccagat catcccgtgg aacttcccgc tcctcatggc gtgctggaag      540

attggcgccg cgctggccat gggctgcacg gtggtgctca agccggcgga gcagacgccg      600

ctctccgcgc tctacctggc caaactgatc caagaggctg gcttcccgcc gggcgtcgtc      660

aatgtcgtgc cgggcttcgg cgagaccgcc ggacaggcac tggtggagca cccggacgtc      720

aacaagattg cgttcaccgg atcgacggag gtcggcaagc tcatcatgcg caacgccgcg      780

gcgaccttga agcgcgtcac gctcgagctc ggcggcaagt ccccgaacat cattctcccc      840

gatgccgaca tgagccgagc catccccggc gcgttcatgg gcatcatgtt caaccagggc      900

caggtgtgct gcgccggatc gcgcctgttc gtgcagaaga aagcgtacga caacgtggtg      960

gccgatctcg tctccctcgc gaagaagatc cgccaaggcc cgggcttgga tcaaggcacg     1020

gagatggggc cgctcgtgtc cgatgaacag gagaagcgcg tgctgggcta catcgagaag     1080

ggcgtggaag agggcgccga ggtcctcgtc ggcggcggca aggccacgga tcgcggatac     1140

ttcgtgcagc cgaccatctt cgccaatgtc cgggacgaca tgaccatcgc gcgcgaggag     1200

atcttcggac cggtggtcgc ggcgatgccg tttgaagatt tggacgaagt cattgcgcgc     1260

gcgaacgaca cggagtacgg cctggcggcc ggtgtgtgga cggagaacat ccggaatgcc     1320

cactatatcg ccagcaagct gaaggccggc actgtttggg tcaactgcta caacgtgttt     1380

gacgcggcgg ctcccttcgg tggatacaag cagtccggta tcgggcgcga aatgggctcg     1440

tacgcgttga acaactacac cgaggtcaag gatgtgtgga tcagcctgag ctga           1494


<210>   630
<211>   442
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   630
Met Val Asn Glu Pro Thr Ala Val Ala Ala Lys Gly Ser Asp Phe Arg 
                5                   10                  15      

Phe Pro Asp Ala Pro Glu Glu Glu Lys Tyr Ser Val Cys Val His Cys 
            20                  25                  30          

Gly Phe Cys Leu Glu Val Cys Pro Thr Tyr Gln Ala Trp Gly Asp Glu 
        35                  40                  45              

Asn His Ser Pro Arg Gly Arg Val Tyr Leu Ile Lys Ala Cys Ala Glu 
    50                  55                  60                  

Gly Glu Leu Pro Leu Asp Glu Ser Val Ile Asp Pro Val Phe Thr Cys 
65                  70                  75                  80  

Leu Asp Cys Arg Ala Cys Glu Thr Val Cys Pro Ser Gly Val Gln Val 
                85                  90                  95      

Gly Ala Leu Val Glu Glu Ala Arg Gly Gln Val Phe Tyr Ala Arg Asp 
            100                 105                 110         

Ala Glu Gly Lys Arg Asp Pro Val Met Arg Phe Phe Leu Arg Gly Val 
        115                 120                 125             

Phe Pro Arg Pro Ala Arg Leu Arg Ile Ile Arg Arg Leu Met Arg Phe 
    130                 135                 140                 

Tyr Gln Lys Ser Gly Leu Gln Lys Leu Ala Arg Ser Thr Gly Val Leu 
145                 150                 155                 160 

Arg Val Leu Pro Pro Gln Val Arg Glu Met Glu Asp Val Ile Pro Glu 
                165                 170                 175     

Ile Gly Arg Gly Pro Ala Ile Asp Val Leu Pro Glu Thr Ile Ala Pro 
            180                 185                 190         

Gln Gly Glu Arg Lys Ala Thr Ala Ala Leu Phe Thr Gly Cys Val Met 
        195                 200                 205             

Asp Val Phe Phe Ser Asp Val Asn Glu Ala Thr Ala Arg Val Leu Val 
    210                 215                 220                 

Arg Asn Gly Val Glu Val Arg Val Pro Lys Asp Gln Ile Cys Cys Gly 
225                 230                 235                 240 

Ala Leu Gln Val His Ala Gly Asp Arg Asp Met Ala Arg Glu Met Ala 
                245                 250                 255     

Lys Arg Asn Ile Glu Val Phe Glu Arg Ala Gly Ala Asp Tyr Val Ala 
            260                 265                 270         

Ile Asn Ala Ala Gly Cys Gly Ala Ala Leu Lys Glu Tyr Pro Glu Leu 
        275                 280                 285             

Phe Arg Asp Asp Pro Ala Trp Arg Asp Arg Ala Val Gln Phe Ser Ser 
    290                 295                 300                 

Arg Val Arg Asp Ile Ser Gln Leu Leu Val Glu Val Gly Phe Asp Pro 
305                 310                 315                 320 

Pro Lys Ala Glu Leu Pro Met Ala Val Thr Tyr His Asp Ala Cys His 
                325                 330                 335     

Leu Phe His Ala Gln Lys Ile Arg Tyr Glu Pro Arg Ser Leu Leu Lys 
            340                 345                 350         

Ser Val Pro Gly Leu Thr Leu Cys Glu Met Pro Asp Ser Asp Arg Cys 
        355                 360                 365             

Cys Gly Ser Ala Gly Ile Tyr Asn Leu Thr His Pro Ala Met Ala Asn 
    370                 375                 380                 

Glu Leu Leu Glu Arg Lys Met Asp Asp Val Pro Glu Gly Val Asp Ala 
385                 390                 395                 400 

Ile Val Met Gly Asn Pro Gly Cys Met Met Gln Ile Arg Leu Gly Val 
                405                 410                 415     

Lys Arg Arg Asn Gln Pro Leu Arg Val Met His Thr Val Glu Val Leu 
            420                 425                 430         

Asp Leu Ala Tyr Arg Arg Glu Gly Ser Arg 
        435                 440         

<210>   631
<211>   1329
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   631
atggtgaacg agcccacggc cgtcgctgcg aaagggtccg attttcgctt tccggacgcg       60

cccgaggaag agaagtactc ggtctgcgtg cattgcggct tctgcctgga ggtgtgtccg      120

acgtatcagg cgtggggcga cgagaatcat tcgccccgcg ggcgcgtgta cctgatcaaa      180

gcgtgcgcag aaggcgagct tccgctcgac gagagcgtga tcgatcccgt cttcacctgc      240

ctcgactgcc gggcctgcga gaccgtgtgc ccgtctggcg tgcaggtggg ggcgctcgtc      300

gaggaggcgc gcggccaggt gttttacgcg cgcgacgcgg aagggaagcg ggaccccgtc      360

atgcgcttct tcctgcgcgg cgtgtttccg cgcccggcgc gccttcggat catccgacgt      420

ctcatgcggt tctatcagaa gtcggggctc cagaaactgg cgcgatcgac cggcgtcctg      480

cgcgtgctgc cgccgcaggt gcgcgagatg gaggacgtca tcccggaaat cggacggggg      540

cccgccatcg acgtcctgcc ggaaacgata gccccgcaag gggagcgcaa ggccacggcg      600

gcgcttttca cgggctgcgt gatggacgtg ttcttctccg acgtgaacga ggccaccgcg      660

cgcgtcctcg tgcgaaacgg cgtcgaggtg cgcgtgccca aggatcagat ctgctgcggc      720

gcgctccagg tgcacgcggg cgatcgcgac atggcccgcg agatggcgaa gcgaaacatc      780

gaggtgtttg agcgcgcggg cgccgattac gtcgccatca acgcggccgg ctgcggcgcc      840

gcgctgaagg aatacccgga gctcttccgc gacgacccgg cctggcggga tcgcgccgtg      900

cagttctcgt cccgcgtgcg cgacatctct cagctcctcg tcgaggtcgg cttcgatccg      960

ccgaaggccg agctgcccat ggccgtcacg taccacgacg cgtgccacct gttccacgcg     1020

cagaagatcc ggtacgagcc gcgatcgctg ctcaagtcgg tgccgggcct gacgctttgc     1080

gagatgccgg attccgaccg atgctgtggc agcgcgggca tctacaacct cacgcacccg     1140

gcgatggcta acgagcttct cgagcgcaag atggacgacg tgcccgaggg cgtggacgcc     1200

atcgtcatgg ggaaccccgg ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac     1260

cagccattgc gcgtcatgca cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga     1320

tcgcgatga                                                             1329


<210>   632
<211>   434
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   632
Pro Ala Cys Ala Thr Ala Ser Leu Gly Asn Tyr Arg Phe Ala Asp Leu 
                5                   10                  15      

Pro Asp Pro Ser Lys Trp Ala Asp Cys Val His Cys Gly Met Cys Leu 
            20                  25                  30          

Glu Ser Cys Pro Thr Tyr Glu Gln Thr Gly Glu Glu Gln His Ser Pro 
        35                  40                  45              

Arg Gly Arg Val His Leu Met Lys Ser Val Gly Glu Gly Lys Leu Asp 
    50                  55                  60                  

Leu Thr Pro Asp Leu Leu Asp Pro Ile Phe Thr Cys Leu Asp Cys Arg 
65                  70                  75                  80  

Ala Cys Thr Thr Ala Cys Pro Ala Asp Val Asp Val Gly Gly Leu Ile 
                85                  90                  95      

Glu Gln Val Arg Gly Gln Leu Arg Gln Ala Val Pro Leu Thr Gly Trp 
            100                 105                 110         

Lys Ala Leu Val Asn Asp Phe Phe Leu Lys Gly Ile Phe Pro His Pro 
        115                 120                 125             

Ser Arg Leu Asp Trp Leu Gly Arg Leu Leu Lys Leu Tyr Gln Gln Ser 
    130                 135                 140                 

Gly Leu Gln Thr Val Ala Arg Lys Thr Gly Met Leu Arg Val Met Pro 
145                 150                 155                 160 

Asp His Leu Ala Glu Met Glu Ala Ile Leu Pro Lys Val Gly Thr Pro 
                165                 170                 175     

Val Arg Lys Lys Tyr Arg Asn Glu Pro Leu Ile Lys Ala Lys Gly Glu 
            180                 185                 190         

Thr Lys Arg Thr Val Ala Ile Leu Thr Gly Cys Ile Met Asp Val Met 
        195                 200                 205             

Phe Ser Asp Ile Asn Glu Ala Thr Ile Arg Val Leu Thr Arg Asn Gly 
    210                 215                 220                 

Asn Asp Val Val Ile Val Ser Asp Gln Thr Cys Cys Gly Ala Leu His 
225                 230                 235                 240 

Val His Ala Gly Asp Arg Glu Thr Gly Arg Lys Leu Ala Lys Gln Asn 
                245                 250                 255     

Ile Glu Ala Phe Gln Gly Val Asp His Val Ile Val Asn Ala Ala Gly 
            260                 265                 270         

Cys Gly Ala Met Leu Lys Glu Tyr Pro Glu Leu Phe Arg His Asp Pro 
        275                 280                 285             

Glu Trp His Glu Lys Ala Glu Gln Phe Ala Ala Lys Val Glu Asp Val 
    290                 295                 300                 

Ser Lys Phe Leu Tyr Asp Thr Gly Phe Lys Ala Pro Lys Ala Glu Leu 
305                 310                 315                 320 

Asn Val Arg Leu Thr Tyr His Asp Ala Cys His Leu Ala His Gly Gln 
                325                 330                 335     

Gly Ile Arg Lys Glu Pro Arg Ala Val Ile Glu Ser Ile Pro Gly Val 
            340                 345                 350         

Glu Met Val Ala Met Pro Asn Ala Asp Arg Cys Cys Gly Ser Ala Gly 
        355                 360                 365             

Ile Tyr Asn Leu Thr His Pro Asp Met Ala Gln Ala Val Leu Glu Ser 
    370                 375                 380                 

Lys Met Gln Asn Val Pro Gln Asp Val Glu Leu Ile Ser Met Gly Asn 
385                 390                 395                 400 

Pro Gly Cys Met Leu Gln Met Ala Leu Gly Val Met Lys His Gly Arg 
                405                 410                 415     

Asn Gln Lys Ile Val His Thr Val Gln Leu Leu Asp Trp Ala Tyr Gln 
            420                 425                 430         

Lys Glu 
        

<210>   633
<211>   435
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   633
Asp Pro Pro Cys Ser Pro Thr Ser Lys Ser Asn Tyr Leu Trp Asn Asp 
                5                   10                  15      

Ala Pro Asp Glu Asn Lys Trp Ala Asp Cys Val His Cys Gly Met Cys 
            20                  25                  30          

Leu Glu Ser Cys Pro Thr Tyr Glu Ile Thr Gly Gln Glu Gln His Ser 
        35                  40                  45              

Pro Arg Gly Arg Val His Leu Ile Lys Ser Val Ala Glu Gly Lys Leu 
    50                  55                  60                  

Glu Val Asn Glu Pro Phe Ile Asp Pro Val Tyr Gln Cys Leu Asp Cys 
65                  70                  75                  80  

Arg Ala Cys Thr Thr Ala Cys Pro Ala Asp Val Asp Val Gly Gly Leu 
                85                  90                  95      

Ile Glu Glu Ala Arg Gly Gln Ile Arg Gln Ala Met Pro Leu Thr Gly 
            100                 105                 110         

Ile Lys Gly Leu Val Ser Lys Phe Phe Leu Glu Gly Leu Phe Pro His 
        115                 120                 125             

Pro Lys Arg Met Gln Ser Leu Gly Gly Leu Leu Lys Ile Tyr Gln Lys 
    130                 135                 140                 

Ser Gly Val Gln Lys Leu Val Arg Thr Thr Arg Leu Ile Arg Ile Met 
145                 150                 155                 160 

Pro Lys His Leu Val Glu Leu Glu Ala Ile Met Pro Gly Met Gly Val 
                165                 170                 175     

Pro Val Arg Lys Lys Tyr Lys Asn Glu Asn Ile Ile Leu Ala Lys Gly 
            180                 185                 190         

Glu Glu Thr His Thr Val Ala Phe Leu Thr Gly Cys Ile Met Asp Val 
        195                 200                 205             

Met Phe Ser Asp Ile Asn Glu Ser Thr Ile Gln Val Leu Thr Arg Asn 
    210                 215                 220                 

Gly Asn Asn Val Thr Ile Pro Lys Gln Gln Thr Cys Cys Gly Ala Leu 
225                 230                 235                 240 

His Val His Ala Gly Asp Arg Glu Thr Gly Arg Arg Leu Ala Lys Gln 
                245                 250                 255     

Asn Ile Glu Ala Phe Glu Asn Ala Gln Thr Val Ile Val Asn Ala Ala 
            260                 265                 270         

Gly Cys Gly Cys Met Leu Lys Asp Tyr Pro Glu Leu Phe Arg Asp Asp 
        275                 280                 285             

Pro Lys Trp His Glu Lys Ala Lys Ala Phe Ser Ala Lys Val Gln Asp 
    290                 295                 300                 

Ile Thr Lys Tyr Leu Tyr Asp Thr Gly Tyr Glu Lys Pro Lys Ser Glu 
305                 310                 315                 320 

Met Lys Ile Arg Leu Thr Tyr His Asp Ala Cys His Leu Ala His Gly 
                325                 330                 335     

Gln Gly Ile Arg Gln Glu Pro Arg Glu Leu Leu His Ala Ile Pro Gly 
            340                 345                 350         

Val Glu Ile Val His Met Pro Asn Ala Asp Arg Cys Cys Gly Ser Ala 
        355                 360                 365             

Gly Ile Tyr Asn Ile Thr Asn Pro Glu Met Ala Gly Ala Val Leu Glu 
    370                 375                 380                 

Ser Lys Met Glu Asn Val Pro Glu Asp Val Glu Met Ile Ser Met Gly 
385                 390                 395                 400 

Asn Pro Gly Cys Met Leu Gln Met Ala Val Gly Val Gln Lys Tyr Gly 
                405                 410                 415     

Arg Arg Gln Lys Ile Val His Thr Val Gln Leu Leu Asn Trp Ala Tyr 
            420                 425                 430         

Lys Arg Asp 
        435 

<210>   634
<211>   427
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   634
Thr Asn Tyr His Trp Ser Asp His Pro Asp Pro Asn Lys Trp Ala Asp 
                5                   10                  15      

Cys Val His Cys Gly Met Cys Leu Glu Ala Cys Pro Thr Tyr Glu Leu 
            20                  25                  30          

Thr Gly His Glu Gln Gln Ser Pro Arg Gly Arg Val His Leu Ile Lys 
        35                  40                  45              

Ser Val Ala Glu Gly Lys Leu Glu Val Asn Glu Ala Phe Ala Asp Pro 
    50                  55                  60                  

Val Phe Thr Cys Leu Asp Cys Arg Ala Cys Glu Thr Ala Cys Pro Ala 
65                  70                  75                  80  

Asp Val Glu Val Gly Gly Leu Ile Glu Glu Ala Arg Gly Gln Ile Arg 
                85                  90                  95      

Gln Ala Leu Pro Leu Ser Gly Trp Lys Lys Val Val Ser His Leu Phe 
            100                 105                 110         

Leu Arg Gly Leu Phe Pro Tyr Pro His Arg Leu His Ala Leu Gly Ser 
        115                 120                 125             

Leu Val Lys Val Tyr Gln Lys Val Gly Ile Arg Lys Ala Val Arg Lys 
    130                 135                 140                 

Thr Gly Leu Leu His Leu Phe Pro Glu His Phe Ala Asp Met Glu Ala 
145                 150                 155                 160 

Val Ile Pro Glu Val Ser Thr Pro Val Gln Lys Arg Tyr Arg Lys Lys 
                165                 170                 175     

Ser Phe Ile Lys Ala Lys Gly Lys Ser Lys Gln Arg Val Thr Leu Leu 
            180                 185                 190         

Ala Gly Cys Val Met Asp Val Met Phe Ser Glu Val Asn Glu Ala Thr 
        195                 200                 205             

Ile Arg Val Leu Thr Arg Asn Gly Asn Asp Val Ser Leu Pro Lys Asp 
    210                 215                 220                 

Gln Thr Cys Cys Gly Ala Leu His Val His Ala Gly Asp Arg Glu Met 
225                 230                 235                 240 

Gly Arg Arg Leu Ala Lys Gln Asn Met Lys Ala Phe Glu Asn Glu Glu 
                245                 250                 255     

Thr Ile Ile Val Asn Ala Ala Gly Cys Gly Ser Met Leu Gln Glu Tyr 
            260                 265                 270         

Pro Glu Leu Phe Arg Glu Val Glu Arg Glu Trp Tyr Glu Arg Ala Glu 
        275                 280                 285             

Ala Phe Ala Glu Lys Val Lys Asp Val Ser Lys His Leu Tyr Asp Thr 
    290                 295                 300                 

Gly Tyr Glu Lys Pro Lys Gly Glu Val Arg Ala Lys Val Ala Tyr His 
305                 310                 315                 320 

Asp Ala Cys His Leu Ala His Gly Gln Asn Val Arg Gln Glu Pro Arg 
                325                 330                 335     

Asp Leu Leu Leu Lys Ile Ser Gly Val Glu Leu Ile Pro Met Glu Asn 
            340                 345                 350         

Ala Asp Arg Cys Cys Gly Ser Ala Gly Ile Tyr Asn Leu Thr His Pro 
        355                 360                 365             

Lys Met Ala Ser Arg Val Leu Glu Lys Lys Met Glu Cys Val Pro Ser 
    370                 375                 380                 

Asp Val Glu Met Val Ser Met Gly Asn Pro Gly Cys Met Leu Gln Met 
385                 390                 395                 400 

Ala Met Gly Val Lys Lys Tyr Gly Gly Asn Gln Arg Ile Ile His Thr 
                405                 410                 415     

Val Gln Leu Leu Asp Leu Ala Tyr Gln Gln Glu 
            420                 425         

<210>   635
<211>   366
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   635
Leu Leu Asp Pro Ile Phe Thr Cys Leu Asp Cys Arg Ala Cys Thr Thr 
                5                   10                  15      

Ala Cys Pro Ala Asp Val Asp Val Gly Gly Leu Ile Glu Gln Val Arg 
            20                  25                  30          

Gly Gln Leu Arg Gln Ala Val Pro Leu Thr Gly Trp Lys Ala Leu Val 
        35                  40                  45              

Ser Asp Val Phe Leu Lys Gly Ile Phe Pro His Pro Ser Arg Leu Asp 
    50                  55                  60                  

Trp Leu Gly Arg Leu Leu Lys Trp Tyr Gln Lys Ser Gly Leu Gln Thr 
65                  70                  75                  80  

Val Ala Arg Lys Thr Gly Leu Leu Arg Val Met Pro Asp His Leu Ala 
                85                  90                  95      

Glu Met Glu Ala Ile Leu Pro Ala Val Gly Thr Pro Val Arg Arg Lys 
            100                 105                 110         

Tyr Lys His Gln Pro Leu Ile Lys Ala Lys Gly Glu Thr Lys Arg Thr 
        115                 120                 125             

Val Ala Ile Leu Thr Gly Cys Val Met Asp Val Met Phe Ser Asp Ile 
    130                 135                 140                 

Asn Glu Ala Thr Ile Arg Val Leu Thr His Asn Gly Asn Asp Val Val 
145                 150                 155                 160 

Ile Val Pro Asn Gln Thr Cys Cys Gly Ala Leu His Val His Ala Gly 
                165                 170                 175     

Asp Arg Glu Thr Gly Arg Lys Leu Ala Lys Gln Asn Ile Glu Ala Phe 
            180                 185                 190         

Gln His Val Asp His Val Ile Val Asn Ala Ala Gly Cys Gly Cys Met 
        195                 200                 205             

Leu Lys Glu Tyr Pro Glu Leu Phe Arg His Asp Pro Glu Trp His Glu 
    210                 215                 220                 

Lys Ala Glu Gln Phe Ala Ala Lys Val Glu Asp Val Ser Lys Phe Leu 
225                 230                 235                 240 

His Asp Thr Gly Phe Lys Pro Pro Lys Ala Glu Leu Asn Val Arg Leu 
                245                 250                 255     

Thr Tyr His Asp Ala Cys His Leu Ala His Gly Gln Gly Ile Arg Gln 
            260                 265                 270         

Glu Pro Arg Ala Leu Ile Glu Ser Ile Pro Gly Val Glu Met Val Ala 
        275                 280                 285             

Met Pro Asn Ala Asp Arg Cys Cys Gly Ser Ala Gly Ile Tyr Asn Leu 
    290                 295                 300                 

Thr His Pro Glu Met Ala Gln Ala Val Leu Glu Ser Lys Met Gln His 
305                 310                 315                 320 

Val Pro Gln Glu Val Glu Leu Ile Ser Met Gly Asn Pro Gly Cys Met 
                325                 330                 335     

Leu Gln Met Ala Leu Gly Val Met Lys His Gly Arg Asn Gln Lys Ile 
            340                 345                 350         

Val His Thr Val Gln Leu Leu Asp Trp Ala Tyr Gln Lys Glu 
        355                 360                 365     

<210>   636
<211>   417
<212>   PRT
<213>   Saccharopolyspora erythraea NRRL 2338

<400>   636
Pro Gln Arg Glu Leu Ile Asp Asp Cys Val His Cys Gly Phe Cys Leu 
                5                   10                  15      

Pro Ser Cys Pro Thr Tyr Glu Leu Trp Gly Glu Glu Met Asp Ser Pro 
            20                  25                  30          

Arg Gly Arg Ile Tyr Leu Met Lys Glu Gly Leu Glu Gly Glu Pro Met 
        35                  40                  45              

Thr Gly Ser Met Val Gly His Phe Asp Ala Cys Leu Gly Cys Met Ala 
    50                  55                  60                  

Cys Val Thr Ala Cys Pro Ser Gly Val Gln Tyr Gly Thr Leu Ile Thr 
65                  70                  75                  80  

Glu Thr Arg Ala Gln Val Glu Arg Arg His Glu Arg Gly Arg Trp Glu 
                85                  90                  95      

Lys Leu Leu Arg Ala Gly Ile Phe Ala Leu Phe Pro Tyr Pro Arg Arg 
            100                 105                 110         

Leu Arg Ala Met Arg Gly Pro Leu Ala Leu Tyr Gln Lys Thr Gly Leu 
        115                 120                 125             

Ser Lys Leu Val Lys Arg Ser Gly Leu Leu Arg Lys Met Pro Ala Ser 
    130                 135                 140                 

Leu Arg Val Met Glu Ser Leu Ala Pro Pro Ile Ser Arg Ala Pro Lys 
145                 150                 155                 160 

Leu Gly Asn Arg Val Pro Ala Arg Gly Thr Arg Arg Ala Thr Val Gly 
                165                 170                 175     

Met Ile Thr Gly Cys Val Gln Ser Ala Phe Phe Pro Asp Val Asn Ala 
            180                 185                 190         

Ala Thr Ala Arg Val Leu Ser Ala Glu Gly Cys Asp Val Val Ile Pro 
        195                 200                 205             

Arg Ala Gln Gly Cys Cys Gly Ala Leu Ser Glu His Thr Gly Arg Glu 
    210                 215                 220                 

Glu Glu Ala Val Arg Phe Ala Arg Asn Leu Leu Asp Thr Phe Glu Asp 
225                 230                 235                 240 

Ala Gly Val Glu Tyr Val Val Ile Asn Ser Ala Gly Cys Gly Ser Thr 
                245                 250                 255     

Leu Lys Glu Tyr Pro Arg Leu Leu Arg Asp Asp Pro Glu Tyr Ala Glu 
            260                 265                 270         

Lys Ala Glu Arg Phe Ser Ala Arg Val Arg Asp Ile Ala Glu Leu Leu 
        275                 280                 285             

Val Glu Leu Gly Pro Val Ala Glu Arg His Pro Leu Pro Val Arg Ala 
    290                 295                 300                 

Ala Tyr His Asp Ala Cys His Leu Ala His Gly Gln Gly Ile Arg Ser 
305                 310                 315                 320 

Gln Pro Arg Glu Leu Leu Arg Gly Ile Pro Gly Met Glu Val Arg Glu 
                325                 330                 335     

Ile Asn Arg Gly Glu Leu Cys Cys Gly Ser Ala Gly Val Tyr Asn Ile 
            340                 345                 350         

Leu Gln Pro Glu Ala Ala Met Asp Leu Gly Asp Arg Lys Ala Glu Asn 
        355                 360                 365             

Val Leu Asp Thr Gly Ala Glu Leu Leu Ile Ser Ala Asn Pro Gly Cys 
    370                 375                 380                 

Ala Met Gln Ile Arg Thr Ser Leu Glu Arg Arg Gly Ser Glu Leu Ala 
385                 390                 395                 400 

Met Ala His Thr Val Glu Val Leu Asp Ala Ser Ile Arg Gly Leu Gly 
                405                 410                 415     

Ala 
    

<210>   637
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   637
Met Val Asn Glu Pro Thr Ala Val Ala Ala Lys Gly Ser Asp Phe Arg 
                5                   10                  15      

Phe Pro Asp Ala Pro Glu Glu Glu Lys Tyr Ser Val Cys Val His Cys 
            20                  25                  30          

Gly Phe Cys Leu Glu Val Cys Pro Thr Tyr Gln Ala Trp Gly Asp Glu 
        35                  40                  45              

Asn His Ser Pro Arg Gly Arg Val Tyr Leu Ile Lys Ala Cys Ala Glu 
    50                  55                  60                  

Gly Glu Leu Pro Leu Asp Glu Ser Val Ile Asp Pro Val Phe Thr Cys 
65                  70                  75                  80  

Leu Asp Cys Arg Ala Cys Glu Thr Val Cys Pro Ser Gly Val Gln Val 
                85                  90                  95      

Gly Ala Leu Val Glu Glu Ala Arg Gly Gln Val Phe Tyr Ala Arg Asp 
            100                 105                 110         

Ala Glu Gly Lys Arg Asp Pro Val Met Arg Phe Phe Leu Arg Gly Val 
        115                 120                 125             

Phe Pro Arg Pro Ala Arg Leu Arg Ile Ile Arg Arg Leu Met Arg Phe 
    130                 135                 140                 

Tyr Gln Lys Ser Gly Leu Gln Lys Leu Ala Arg Ser Thr Gly Val Leu 
145                 150                 155                 160 

Arg Val Leu Pro Pro Gln Val Arg Glu Met Glu Asp Val Ile Pro Glu 
                165                 170                 175     

Ile Gly Arg Gly Pro Ala Ile Asp Val Leu Pro Glu Thr Ile Ala Pro 
            180                 185                 190         

Gln Gly Glu Arg Arg Ala Thr Ala Ala Leu Phe Thr Gly Cys Val Met 
        195                 200                 205             

Asp Val Phe Phe Ser Asp Val Asn Glu Ala Thr Ala Arg Val Leu Val 
    210                 215                 220                 

Arg Asn Gly Val Glu Val Arg Val Pro Lys Asp Gln Ile Cys Cys Gly 
225                 230                 235                 240 

Ala Leu Gln Val His Ala Gly Asp Arg Asp Met Ala Arg Glu Met Ala 
                245                 250                 255     

Lys Arg Asn Ile Glu Val Phe Glu Arg Ala Gly Ala Asp Tyr Val Ala 
            260                 265                 270         

Ile Asn Ala Ala Gly Cys Gly Ala Ala Leu Lys Glu Tyr Pro Glu Leu 
        275                 280                 285             

Phe Arg Asp Asp Pro Ala Trp Arg Asp Arg Ala Val Gln Phe Ser Ser 
    290                 295                 300                 

Arg Val Arg Asp Ile Ser Gln Leu Leu Val Glu Val Gly Phe Asp Pro 
305                 310                 315                 320 

Pro Lys Ala Glu Leu Pro Met Ala Val Thr Tyr His Asp Ala Cys His 
                325                 330                 335     

Leu Phe His Ala Gln Lys Ile Arg Tyr Glu Pro Arg Ser Leu Leu Lys 
            340                 345                 350         

Ser Val Pro Gly Leu Thr Leu Cys Glu Met Pro Asp Ser Asp Arg Cys 
        355                 360                 365             

Cys Gly Ser Ala Gly Ile Tyr Asn Leu Thr His Pro Ala Met Ala Asn 
    370                 375                 380                 

Glu Leu Leu Glu Arg Lys Met Asp Asp Val Pro Glu Gly Val Asp Ala 
385                 390                 395                 400 

Ile Val Met Gly Asn Pro Gly Cys Met Met Gln Ile Arg Leu Gly Val 
                405                 410                 415     

Lys Arg Arg Asn Gln Pro Leu Arg Val Met His Thr Val Glu Val Leu 
            420                 425                 430         

Asp Leu Ala Tyr Arg Arg Glu Gly Ser Arg 
        435                 440         

<210>   638
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   638
Met Val Asn Glu Pro Thr Ala Val Ala Ala Lys Gly Ser Asp Phe Arg 
                5                   10                  15      

Phe Pro Asp Ala Pro Glu Glu Glu Lys Tyr Ser Val Cys Val His Cys 
            20                  25                  30          

Gly Phe Cys Leu Glu Val Cys Pro Thr Tyr Gln Ala Trp Gly Asp Glu 
        35                  40                  45              

Asn His Ser Pro Arg Gly Arg Val Tyr Leu Ile Lys Ala Cys Ala Glu 
    50                  55                  60                  

Gly Glu Leu Pro Leu Asp Glu Ser Val Ile Asp Pro Val Phe Thr Cys 
65                  70                  75                  80  

Leu Asp Cys Arg Ala Cys Glu Thr Val Cys Pro Ser Gly Val Gln Val 
                85                  90                  95      

Gly Ala Leu Val Glu Glu Ala Arg Gly Gln Val Phe Tyr Ala Arg Asp 
            100                 105                 110         

Ala Glu Gly Lys Arg Asp Pro Val Met Arg Phe Phe Leu Arg Gly Val 
        115                 120                 125             

Phe Pro Arg Pro Ala Arg Leu Arg Ile Ile Arg Arg Leu Met Arg Phe 
    130                 135                 140                 

Tyr Gln Lys Ser Gly Leu Gln Lys Ile Ala Arg Ser Thr Gly Val Leu 
145                 150                 155                 160 

Arg Val Leu Pro Pro Gln Val Arg Glu Met Glu Asp Val Ile Pro Glu 
                165                 170                 175     

Ile Gly Arg Gly Pro Ala Ile Asp Val Leu Pro Glu Thr Ile Ala Pro 
            180                 185                 190         

Gln Gly Glu Arg Lys Ala Thr Ala Ala Leu Phe Thr Gly Cys Val Met 
        195                 200                 205             

Asp Val Phe Phe Ser Asp Val Asn Glu Ala Thr Ala Arg Val Leu Val 
    210                 215                 220                 

Arg Asn Gly Val Glu Val Arg Val Pro Lys Asp Gln Ile Cys Cys Gly 
225                 230                 235                 240 

Ala Leu Gln Val His Ala Gly Asp Arg Asp Met Ala Arg Glu Met Ala 
                245                 250                 255     

Lys Arg Asn Ile Glu Val Phe Glu Arg Ala Gly Ala Asp Tyr Val Ala 
            260                 265                 270         

Ile Asn Ala Ala Gly Cys Gly Ala Ala Leu Lys Glu Tyr Pro Glu Leu 
        275                 280                 285             

Phe Arg Asp Asp Pro Ala Trp Arg Asp Arg Ala Val Gln Phe Ser Ser 
    290                 295                 300                 

Arg Val Arg Asp Ile Ser Gln Leu Leu Val Glu Val Gly Phe Asp Pro 
305                 310                 315                 320 

Pro Lys Ala Glu Leu Pro Met Ala Val Thr Tyr His Asp Ala Cys His 
                325                 330                 335     

Leu Phe His Ala Gln Lys Ile Arg Tyr Glu Pro Arg Ser Leu Leu Lys 
            340                 345                 350         

Ser Val Pro Gly Leu Thr Leu Cys Glu Met Pro Asp Ser Asp Arg Cys 
        355                 360                 365             

Cys Gly Ser Ala Gly Ile Tyr Asn Leu Thr His Pro Ala Met Ala Asn 
    370                 375                 380                 

Glu Leu Leu Glu Arg Lys Met Asp Asp Val Pro Glu Gly Val Asp Ala 
385                 390                 395                 400 

Ile Val Met Gly Asn Pro Gly Cys Met Met Gln Ile Arg Leu Gly Val 
                405                 410                 415     

Lys Arg Arg Asn Gln Pro Leu Arg Val Met His Thr Val Glu Val Leu 
            420                 425                 430         

Asp Leu Ala Tyr Arg Arg Glu Gly Ser Arg 
        435                 440         

<210>   639
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   639
Met Val Asn Glu Pro Thr Ala Val Ala Ala Lys Gly Ser Asp Phe Arg 
                5                   10                  15      

Phe Pro Asp Ala Pro Glu Glu Glu Lys Tyr Ser Val Cys Val His Cys 
            20                  25                  30          

Gly Phe Cys Leu Glu Val Cys Pro Thr Tyr Gln Ala Trp Gly Asp Glu 
        35                  40                  45              

Asn His Ser Pro Arg Gly Arg Val Tyr Leu Ile Lys Ala Cys Ala Glu 
    50                  55                  60                  

Gly Glu Leu Pro Leu Asp Glu Ser Val Ile Asp Pro Val Phe Thr Cys 
65                  70                  75                  80  

Leu Asp Cys Arg Ala Cys Glu Thr Val Cys Pro Ser Gly Val Gln Val 
                85                  90                  95      

Gly Ala Leu Val Glu Glu Ala Arg Gly Gln Val Phe Tyr Ala Arg Asp 
            100                 105                 110         

Ala Glu Gly Lys Arg Asp Pro Val Met Arg Phe Phe Leu Arg Gly Val 
        115                 120                 125             

Phe Pro Arg Pro Ala Arg Leu Arg Ile Ile Arg Arg Leu Met Arg Phe 
    130                 135                 140                 

Tyr Gln Lys Ser Gly Leu Gln Lys Leu Ala Arg Ser Thr Gly Val Leu 
145                 150                 155                 160 

Arg Val Leu Pro Pro Gln Val Arg Glu Met Glu Asp Val Ile Pro Glu 
                165                 170                 175     

Ile Gly Arg Gly Pro Ala Ile Asp Val Leu Pro Glu Thr Ile Ala Pro 
            180                 185                 190         

Gln Gly Glu Arg Lys Ala Thr Ala Ala Leu Phe Thr Gly Cys Val Met 
        195                 200                 205             

Asp Val Phe Phe Ser Asp Val Asn Glu Ala Thr Ala Arg Val Leu Val 
    210                 215                 220                 

Arg Asn Gly Val Glu Val Arg Val Pro Lys Asp Gln Ile Cys Cys Gly 
225                 230                 235                 240 

Ala Leu Gln Val His Ala Gly Asp Arg Asp Met Ala Arg Glu Met Ala 
                245                 250                 255     

Lys Arg Asn Ile Glu Val Phe Glu Arg Ala Gly Ala Asp Tyr Val Ala 
            260                 265                 270         

Ile Asn Ala Ala Gly Cys Gly Ala Ala Leu Lys Glu Tyr Pro Glu Leu 
        275                 280                 285             

Phe Arg Asp Asp Pro Ala Trp Arg Asp Arg Ala Val Gln Phe Ser Ser 
    290                 295                 300                 

Arg Val Arg Asp Ile Ser Gln Leu Leu Val Glu Val Gly Phe Asp Pro 
305                 310                 315                 320 

Pro Lys Ala Glu Leu Pro Met Ala Val Thr Tyr His Asp Ala Cys His 
                325                 330                 335     

Leu Phe His Ala Gln Lys Ile Arg Tyr Glu Pro Arg Ser Leu Leu Lys 
            340                 345                 350         

Ser Val Pro Gly Leu Thr Leu Cys Glu Met Pro Asp Ser Asp Arg Cys 
        355                 360                 365             

Cys Gly Ser Ala Gly Ile Tyr Asn Leu Thr His Pro Ala Met Ala Asn 
    370                 375                 380                 

Glu Leu Leu Glu Arg Lys Met Asp Asp Val Pro Glu Gly Val Asp Ala 
385                 390                 395                 400 

Ile Val Met Gly Asn Pro Gly Cys Met Met Gln Ile Arg Leu Gly Val 
                405                 410                 415     

Lys Arg Arg Asn Gln Pro Leu Arg Val Met His Thr Val Glu Val Leu 
            420                 425                 430         

Asp Leu Ala Tyr Arg Arg Glu Gly Ser Lys 
        435                 440         

<210>   640
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   640
Met Val Asn Glu Pro Thr Ala Val Ala Ala Lys Gly Ser Asp Phe Arg 
                5                   10                  15      

Phe Pro Asp Ala Pro Glu Glu Glu Lys Tyr Ser Val Cys Val His Cys 
            20                  25                  30          

Gly Phe Cys Leu Glu Val Cys Pro Thr Tyr Gln Ala Trp Gly Asp Glu 
        35                  40                  45              

Asn His Ser Pro Arg Gly Arg Val Tyr Leu Ile Lys Ala Cys Ala Glu 
    50                  55                  60                  

Gly Glu Leu Pro Leu Asp Glu Ser Val Ile Asp Pro Val Phe Thr Cys 
65                  70                  75                  80  

Leu Asp Cys Arg Ala Cys Glu Thr Val Cys Pro Ser Gly Val Gln Val 
                85                  90                  95      

Gly Ala Leu Val Glu Glu Ala Arg Gly Gln Val Phe Tyr Ala Arg Asp 
            100                 105                 110         

Ala Glu Gly Lys Arg Asp Pro Val Met Arg Phe Phe Leu Arg Gly Val 
        115                 120                 125             

Phe Pro Arg Pro Ala Arg Leu Arg Ile Ile Arg Arg Leu Met Arg Phe 
    130                 135                 140                 

Tyr Gln Lys Ser Gly Leu Gln Lys Leu Ala Arg Ser Thr Gly Val Leu 
145                 150                 155                 160 

Arg Val Leu Pro Pro Gln Val Arg Glu Met Glu Asp Val Ile Pro Glu 
                165                 170                 175     

Ile Gly Arg Gly Pro Ala Ile Asp Val Leu Pro Glu Thr Ile Ala Pro 
            180                 185                 190         

Gln Gly Glu Arg Lys Ala Thr Ala Ala Leu Phe Thr Gly Cys Val Met 
        195                 200                 205             

Asp Val Phe Phe Ser Asp Val Asn Glu Ala Thr Ala Arg Val Leu Val 
    210                 215                 220                 

Arg Asn Gly Val Glu Val Arg Val Pro Lys Asp Gln Ile Cys Cys Gly 
225                 230                 235                 240 

Ala Leu Gln Val His Ala Gly Asp Arg Asp Met Ala Arg Glu Met Ala 
                245                 250                 255     

Lys Arg Asn Ile Glu Val Phe Glu Arg Ala Gly Ala Asp Tyr Val Ala 
            260                 265                 270         

Ile Asn Ala Ala Gly Cys Gly Ala Ala Leu Lys Glu Tyr Pro Glu Leu 
        275                 280                 285             

Phe Arg Asp Asp Pro Ala Trp Arg Asp Arg Ala Val Gln Phe Ser Ser 
    290                 295                 300                 

Arg Val Arg Asp Ile Ser Gln Leu Leu Val Glu Val Gly Phe Asp Pro 
305                 310                 315                 320 

Pro Lys Ala Glu Leu Pro Met Ala Val Thr Tyr His Asp Ala Cys His 
                325                 330                 335     

Leu Phe His Ala Gln Lys Ile Arg Tyr Glu Pro Arg Ser Leu Leu Lys 
            340                 345                 350         

Ser Val Pro Gly Leu Thr Leu Cys Glu Met Pro Asp Ser Asp Arg Cys 
        355                 360                 365             

Cys Gly Ser Ala Gly Ile Tyr Asn Leu Thr His Pro Ala Met Ala Asn 
    370                 375                 380                 

Glu Leu Leu Glu Arg Lys Met Asp Asp Val Pro Glu Gly Val Asp Ala 
385                 390                 395                 400 

Ile Val Met Gly Asn Pro Gly Cys Met Met Gln Ile Arg Ile Gly Val 
                405                 410                 415     

Lys Arg Arg Asn Gln Pro Leu Arg Val Met His Thr Val Glu Val Leu 
            420                 425                 430         

Asp Leu Ala Tyr Arg Arg Glu Gly Ser Arg 
        435                 440         

<210>   641
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   641
Met Val Asn Glu Pro Thr Ala Val Ala Ala Lys Gly Ser Asp Phe Arg 
                5                   10                  15      

Phe Pro Asp Ala Pro Glu Glu Glu Lys Tyr Ser Val Cys Val His Cys 
            20                  25                  30          

Gly Phe Cys Leu Glu Val Cys Pro Thr Tyr Gln Ala Trp Gly Asp Glu 
        35                  40                  45              

Asn His Ser Pro Arg Gly Arg Val Tyr Leu Ile Lys Ala Cys Ala Glu 
    50                  55                  60                  

Gly Glu Leu Pro Leu Asp Glu Ser Val Ile Asp Pro Val Phe Thr Cys 
65                  70                  75                  80  

Leu Asp Cys Arg Ala Cys Glu Thr Val Cys Pro Ser Gly Val Gln Val 
                85                  90                  95      

Gly Ala Leu Val Glu Glu Ala Arg Gly Gln Val Phe Tyr Ala Arg Asp 
            100                 105                 110         

Ala Glu Gly Lys Arg Asp Pro Val Met Arg Phe Phe Leu Arg Gly Val 
        115                 120                 125             

Phe Pro Arg Pro Ala Arg Leu Arg Ile Ile Arg Arg Leu Met Arg Phe 
    130                 135                 140                 

Tyr Gln Lys Ser Gly Leu Gln Lys Leu Ala Arg Ser Thr Gly Val Leu 
145                 150                 155                 160 

Arg Val Leu Pro Pro Gln Val Arg Glu Met Glu Asp Val Ile Pro Glu 
                165                 170                 175     

Ile Gly Arg Gly Pro Ala Ile Asp Val Leu Pro Glu Thr Ile Ala Pro 
            180                 185                 190         

Gln Gly Glu Arg Lys Ala Thr Ala Ala Leu Phe Thr Gly Cys Val Met 
        195                 200                 205             

Asp Val Phe Phe Ser Asp Val Asn Glu Ala Thr Ala Arg Val Leu Val 
    210                 215                 220                 

Arg Asn Gly Val Glu Val Lys Val Pro Lys Asp Gln Ile Cys Cys Gly 
225                 230                 235                 240 

Ala Leu Gln Val His Ala Gly Asp Arg Asp Met Ala Arg Glu Met Ala 
                245                 250                 255     

Lys Arg Asn Ile Glu Val Phe Glu Arg Ala Gly Ala Asp Tyr Val Ala 
            260                 265                 270         

Ile Asn Ala Ala Gly Cys Gly Ala Ala Leu Lys Glu Tyr Pro Glu Leu 
        275                 280                 285             

Phe Arg Asp Asp Pro Ala Trp Arg Asp Arg Ala Val Gln Phe Ser Ser 
    290                 295                 300                 

Arg Val Arg Asp Ile Ser Gln Leu Leu Val Glu Val Gly Phe Asp Pro 
305                 310                 315                 320 

Pro Lys Ala Glu Leu Pro Met Ala Val Thr Tyr His Asp Ala Cys His 
                325                 330                 335     

Leu Phe His Ala Gln Lys Ile Arg Tyr Glu Pro Arg Ser Leu Leu Lys 
            340                 345                 350         

Ser Val Pro Gly Leu Thr Leu Cys Glu Met Pro Asp Ser Asp Arg Cys 
        355                 360                 365             

Cys Gly Ser Ala Gly Ile Tyr Asn Leu Thr His Pro Ala Met Ala Asn 
    370                 375                 380                 

Glu Leu Leu Glu Arg Lys Met Asp Asp Val Pro Glu Gly Val Asp Ala 
385                 390                 395                 400 

Ile Val Met Gly Asn Pro Gly Cys Met Met Gln Ile Arg Leu Gly Val 
                405                 410                 415     

Lys Arg Arg Asn Gln Pro Leu Arg Val Met His Thr Val Glu Val Leu 
            420                 425                 430         

Asp Leu Ala Tyr Arg Arg Glu Gly Ser Arg 
        435                 440         

<210>   642
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   642
atggtgaacg agcccacggc cgtcgctgcg aaagggtccg attttcgctt tccggacgcg       60

cccgaggaag agaagtactc ggtctgcgtg cattgcggct tctgcctgga ggtgtgtccg      120

acgtatcagg cgtggggcga cgagaatcat tcgccccgcg ggcgcgtgta cctgatcaaa      180

gcgtgcgcag aaggcgagct tccgctcgac gagagcgtga tcgatcccgt cttcacctgc      240

ctcgactgcc gggcctgcga gaccgtgtgc ccgtctggcg tgcaggtggg ggcgctcgtc      300

gaggaggcgc gcggccaggt gttttacgcg cgcgacgcgg aagggaagcg ggaccccgtc      360

atgcgcttct tcctgcgcgg cgtgtttccg cgcccggcgc gccttcggat catccgacgt      420

ctcatgcggt tctatcagaa gtcggggctc cagaaactgg cgcgatcgac cggcgtcctg      480

cgcgtgctgc cgccgcaggt gcgcgagatg gaggacgtca tcccggaaat cggacggggg      540

cccgccatcg acgtcctgcc ggaaacgata gccccgcaag gggagcgccg tgccacggcg      600

gcgcttttca cgggctgcgt gatggacgtg ttcttctccg acgtgaacga ggccaccgcg      660

cgcgtcctcg tgcgaaacgg cgtcgaggtg cgcgtgccca aggatcagat ctgctgcggc      720

gcgctccagg tgcacgcggg cgatcgcgac atggcccgcg agatggcgaa gcgaaacatc      780

gaggtgtttg agcgcgcggg cgccgattac gtcgccatca acgcggccgg ctgcggcgcc      840

gcgctgaagg aatacccgga gctcttccgc gacgacccgg cctggcggga tcgcgccgtg      900

cagttctcgt cccgcgtgcg cgacatctct cagctcctcg tcgaggtcgg cttcgatccg      960

ccgaaggccg agctgcccat ggccgtcacg taccacgacg cgtgccacct gttccacgcg     1020

cagaagatcc ggtacgagcc gcgatcgctg ctcaagtcgg tgccgggcct gacgctttgc     1080

gagatgccgg attccgaccg atgctgtggc agcgcgggca tctacaacct cacgcacccg     1140

gcgatggcta acgagcttct cgagcgcaag atggacgacg tgcccgaggg cgtggacgcc     1200

atcgtcatgg ggaaccccgg ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac     1260

cagccattgc gcgtcatgca cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga     1320

tcgcgatga                                                             1329


<210>   643
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   643
atggtgaacg agcccacggc cgtcgctgcg aaagggtccg attttcgctt tccggacgcg       60

cccgaggaag agaagtactc ggtctgcgtg cattgcggct tctgcctgga ggtgtgtccg      120

acgtatcagg cgtggggcga cgagaatcat tcgccccgcg ggcgcgtgta cctgatcaaa      180

gcgtgcgcag aaggcgagct tccgctcgac gagagcgtga tcgatcccgt cttcacctgc      240

ctcgactgcc gggcctgcga gaccgtgtgc ccgtctggcg tgcaggtggg ggcgctcgtc      300

gaggaggcgc gcggccaggt gttttacgcg cgcgacgcgg aagggaagcg ggaccccgtc      360

atgcgcttct tcctgcgcgg cgtgtttccg cgcccggcgc gccttcggat catccgacgt      420

ctcatgcggt tctatcagaa gtcggggctc cagaaaattg cgcgatcgac cggcgtcctg      480

cgcgtgctgc cgccgcaggt gcgcgagatg gaggacgtca tcccggaaat cggacggggg      540

cccgccatcg acgtcctgcc ggaaacgata gccccgcaag gggagcgcaa ggccacggcg      600

gcgcttttca cgggctgcgt gatggacgtg ttcttctccg acgtgaacga ggccaccgcg      660

cgcgtcctcg tgcgaaacgg cgtcgaggtg cgcgtgccca aggatcagat ctgctgcggc      720

gcgctccagg tgcacgcggg cgatcgcgac atggcccgcg agatggcgaa gcgaaacatc      780

gaggtgtttg agcgcgcggg cgccgattac gtcgccatca acgcggccgg ctgcggcgcc      840

gcgctgaagg aatacccgga gctcttccgc gacgacccgg cctggcggga tcgcgccgtg      900

cagttctcgt cccgcgtgcg cgacatctct cagctcctcg tcgaggtcgg cttcgatccg      960

ccgaaggccg agctgcccat ggccgtcacg taccacgacg cgtgccacct gttccacgcg     1020

cagaagatcc ggtacgagcc gcgatcgctg ctcaagtcgg tgccgggcct gacgctttgc     1080

gagatgccgg attccgaccg atgctgtggc agcgcgggca tctacaacct cacgcacccg     1140

gcgatggcta acgagcttct cgagcgcaag atggacgacg tgcccgaggg cgtggacgcc     1200

atcgtcatgg ggaaccccgg ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac     1260

cagccattgc gcgtcatgca cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga     1320

tcgcgatga                                                             1329


<210>   644
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   644
atggtgaacg agcccacggc cgtcgctgcg aaagggtccg attttcgctt tccggacgcg       60

cccgaggaag agaagtactc ggtctgcgtg cattgcggct tctgcctgga ggtgtgtccg      120

acgtatcagg cgtggggcga cgagaatcat tcgccccgcg ggcgcgtgta cctgatcaaa      180

gcgtgcgcag aaggcgagct tccgctcgac gagagcgtga tcgatcccgt cttcacctgc      240

ctcgactgcc gggcctgcga gaccgtgtgc ccgtctggcg tgcaggtggg ggcgctcgtc      300

gaggaggcgc gcggccaggt gttttacgcg cgcgacgcgg aagggaagcg ggaccccgtc      360

atgcgcttct tcctgcgcgg cgtgtttccg cgcccggcgc gccttcggat catccgacgt      420

ctcatgcggt tctatcagaa gtcggggctc cagaaactgg cgcgatcgac cggcgtcctg      480

cgcgtgctgc cgccgcaggt gcgcgagatg gaggacgtca tcccggaaat cggacggggg      540

cccgccatcg acgtcctgcc ggaaacgata gccccgcaag gggagcgcaa ggccacggcg      600

gcgcttttca cgggctgcgt gatggacgtg ttcttctccg acgtgaacga ggccaccgcg      660

cgcgtcctcg tgcgaaacgg cgtcgaggtg cgcgtgccca aggatcagat ctgctgcggc      720

gcgctccagg tgcacgcggg cgatcgcgac atggcccgcg agatggcgaa gcgaaacatc      780

gaggtgtttg agcgcgcggg cgccgattac gtcgccatca acgcggccgg ctgcggcgcc      840

gcgctgaagg aatacccgga gctcttccgc gacgacccgg cctggcggga tcgcgccgtg      900

cagttctcgt cccgcgtgcg cgacatctct cagctcctcg tcgaggtcgg cttcgatccg      960

ccgaaggccg agctgcccat ggccgtcacg taccacgacg cgtgccacct gttccacgcg     1020

cagaagatcc ggtacgagcc gcgatcgctg ctcaagtcgg tgccgggcct gacgctttgc     1080

gagatgccgg attccgaccg atgctgtggc agcgcgggca tctacaacct cacgcacccg     1140

gcgatggcta acgagcttct cgagcgcaag atggacgacg tgcccgaggg cgtggacgcc     1200

atcgtcatgg ggaaccccgg ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac     1260

cagccattgc gcgtcatgca cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga     1320

tcgaaatga                                                             1329


<210>   645
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   645
atggtgaacg agcccacggc cgtcgctgcg aaagggtccg attttcgctt tccggacgcg       60

cccgaggaag agaagtactc ggtctgcgtg cattgcggct tctgcctgga ggtgtgtccg      120

acgtatcagg cgtggggcga cgagaatcat tcgccccgcg ggcgcgtgta cctgatcaaa      180

gcgtgcgcag aaggcgagct tccgctcgac gagagcgtga tcgatcccgt cttcacctgc      240

ctcgactgcc gggcctgcga gaccgtgtgc ccgtctggcg tgcaggtggg ggcgctcgtc      300

gaggaggcgc gcggccaggt gttttacgcg cgcgacgcgg aagggaagcg ggaccccgtc      360

atgcgcttct tcctgcgcgg cgtgtttccg cgcccggcgc gccttcggat catccgacgt      420

ctcatgcggt tctatcagaa gtcggggctc cagaaactgg cgcgatcgac cggcgtcctg      480

cgcgtgctgc cgccgcaggt gcgcgagatg gaggacgtca tcccggaaat cggacggggg      540

cccgccatcg acgtcctgcc ggaaacgata gccccgcaag gggagcgcaa ggccacggcg      600

gcgcttttca cgggctgcgt gatggacgtg ttcttctccg acgtgaacga ggccaccgcg      660

cgcgtcctcg tgcgaaacgg cgtcgaggtg cgcgtgccca aggatcagat ctgctgcggc      720

gcgctccagg tgcacgcggg cgatcgcgac atggcccgcg agatggcgaa gcgaaacatc      780

gaggtgtttg agcgcgcggg cgccgattac gtcgccatca acgcggccgg ctgcggcgcc      840

gcgctgaagg aatacccgga gctcttccgc gacgacccgg cctggcggga tcgcgccgtg      900

cagttctcgt cccgcgtgcg cgacatctct cagctcctcg tcgaggtcgg cttcgatccg      960

ccgaaggccg agctgcccat ggccgtcacg taccacgacg cgtgccacct gttccacgcg     1020

cagaagatcc ggtacgagcc gcgatcgctg ctcaagtcgg tgccgggcct gacgctttgc     1080

gagatgccgg attccgaccg atgctgtggc agcgcgggca tctacaacct cacgcacccg     1140

gcgatggcta acgagcttct cgagcgcaag atggacgacg tgcccgaggg cgtggacgcc     1200

atcgtcatgg ggaaccccgg ttgcatgatg cagatccgga ttggcgtcaa gcgcaggaac     1260

cagccattgc gcgtcatgca cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga     1320

tcgcgatga                                                             1329


<210>   646
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   646
atggtgaacg agcccacggc cgtcgctgcg aaagggtccg attttcgctt tccggacgcg       60

cccgaggaag agaagtactc ggtctgcgtg cattgcggct tctgcctgga ggtgtgtccg      120

acgtatcagg cgtggggcga cgagaatcat tcgccccgcg ggcgcgtgta cctgatcaaa      180

gcgtgcgcag aaggcgagct tccgctcgac gagagcgtga tcgatcccgt cttcacctgc      240

ctcgactgcc gggcctgcga gaccgtgtgc ccgtctggcg tgcaggtggg ggcgctcgtc      300

gaggaggcgc gcggccaggt gttttacgcg cgcgacgcgg aagggaagcg ggaccccgtc      360

atgcgcttct tcctgcgcgg cgtgtttccg cgcccggcgc gccttcggat catccgacgt      420

ctcatgcggt tctatcagaa gtcggggctc cagaaactgg cgcgatcgac cggcgtcctg      480

cgcgtgctgc cgccgcaggt gcgcgagatg gaggacgtca tcccggaaat cggacggggg      540

cccgccatcg acgtcctgcc ggaaacgata gccccgcaag gggagcgcaa ggccacggcg      600

gcgcttttca cgggctgcgt gatggacgtg ttcttctccg acgtgaacga ggccaccgcg      660

cgcgtcctcg tgcgaaacgg cgtcgaggtg aaagtgccca aggatcagat ctgctgcggc      720

gcgctccagg tgcacgcggg cgatcgcgac atggcccgcg agatggcgaa gcgaaacatc      780

gaggtgtttg agcgcgcggg cgccgattac gtcgccatca acgcggccgg ctgcggcgcc      840

gcgctgaagg aatacccgga gctcttccgc gacgacccgg cctggcggga tcgcgccgtg      900

cagttctcgt cccgcgtgcg cgacatctct cagctcctcg tcgaggtcgg cttcgatccg      960

ccgaaggccg agctgcccat ggccgtcacg taccacgacg cgtgccacct gttccacgcg     1020

cagaagatcc ggtacgagcc gcgatcgctg ctcaagtcgg tgccgggcct gacgctttgc     1080

gagatgccgg attccgaccg atgctgtggc agcgcgggca tctacaacct cacgcacccg     1140

gcgatggcta acgagcttct cgagcgcaag atggacgacg tgcccgaggg cgtggacgcc     1200

atcgtcatgg ggaaccccgg ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac     1260

cagccattgc gcgtcatgca cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga     1320

tcgcgatga                                                             1329


<210>   647
<211>   544
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   647
Met His Asp Ala Asp Pro Ala Arg Arg Gln Ala Gln Glu Pro Ala Ile 
                5                   10                  15      

Ala Arg His Ala His Gly Arg Ser Ala Arg Ser Arg Leu Pro Glu Gly 
            20                  25                  30          

Gly Ile Ala Met Arg Asp Val His Ile Asp Arg Leu Val Glu Ile Val 
        35                  40                  45              

Gly Glu Arg Arg Cys Leu Trp Arg Pro His Gln Val Lys Ala Tyr Ala 
    50                  55                  60                  

Cys Asp Gly Tyr Thr Ala Glu Glu Gly Leu Pro Arg Ala Val Val Phe 
65                  70                  75                  80  

Pro Glu Ser Thr Asp Glu Val Ala Arg Ile Cys Arg Tyr Leu Tyr Glu 
                85                  90                  95      

Asn Asp Ile Pro Tyr Leu Pro Arg Gly Ala Gly Thr Gly Leu Ser Gly 
            100                 105                 110         

Gly Ala Thr Pro Thr Gly Gly Glu Val Val Ile Ser Leu Ala Arg Met 
        115                 120                 125             

Asn Lys Leu Leu Ala Val Asp Phe Asp Asn Leu Arg Ala Val Val Gln 
    130                 135                 140                 

Pro Gly Leu Val Asn Leu Thr Leu Thr Arg Arg Val Ser His Ala Asp 
145                 150                 155                 160 

Cys Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Ser Val Cys Thr Ile Gly 
                165                 170                 175     

Gly Asn Phe Ala Glu Asn Ala Gly Gly Ser His Cys Leu Lys Tyr Gly 
            180                 185                 190         

Val Thr Thr Asn His Val Val Ala Ala Lys Val Val Leu Pro Asp Gly 
        195                 200                 205             

Asp Val Ile Asp Val Gly Ala Pro Phe Gly Asp Ala Pro Gly Tyr Asp 
    210                 215                 220                 

Leu Leu Gly Leu Leu Val Gly Ser Glu Gly Thr Leu Gly Ile Ala Thr 
225                 230                 235                 240 

Glu Ile Thr Val Arg Ile Leu Lys Lys Pro Gln Ala Leu Arg Thr Ala 
                245                 250                 255     

Leu Ala Tyr Phe Asp Arg Val Ala Asp Ala Ser Asp Thr Val Thr Asp 
            260                 265                 270         

Ile Ile Gly Ala Gly Ile Ile Pro Ala Ala Ile Glu Met Met Asp Gln 
        275                 280                 285             

Leu Ala Met Gln Ala Val Asp Lys Ser Asn Tyr His Val Gly Tyr Pro 
    290                 295                 300                 

Thr Asp Ile Glu Ala Val Leu Leu Ile Glu Val Asp Gly Leu Ala Ala 
305                 310                 315                 320 

Gly Val Asp Glu Val Met Ala Arg Val Val Glu Ile Cys Arg Arg His 
                325                 330                 335     

Arg Val Arg Glu Val Arg Val Ala Gln Ser Asp Ala Glu Arg Ala Leu 
            340                 345                 350         

Trp Trp Ser Ser Arg Lys Met Ala Phe Gly Ala Met Gly Arg Ile Ser 
        355                 360                 365             

Pro Asp Tyr Ile Val Gln Asp Gly Val Ile Pro Arg Thr Arg Leu Thr 
    370                 375                 380                 

Glu Val Leu Gln Lys Ile Asp Glu Val Ser Arg Arg Tyr Gly Leu Lys 
385                 390                 395                 400 

Ile Ala Asn Val Phe His Ala Gly Asp Gly Asn Leu His Pro Leu Ile 
                405                 410                 415     

Leu Tyr Asp Ser Arg Val Pro Gly Glu Ala Glu Arg Ala Val Arg Ala 
            420                 425                 430         

Gly Ser Glu Val Leu Arg Ala Cys Val Asp Ala Gly Gly Ser Ile Thr 
        435                 440                 445             

Gly Glu His Gly Val Gly Ile Glu Lys Ile Gly Glu Met Ala Tyr Met 
    450                 455                 460                 

Phe Ser Glu Asp Glu Ile His Ala Gln Arg Ala Val Lys Ser Cys Phe 
465                 470                 475                 480 

Asp Pro Lys Gly Ile Val Asn Ala Gly Lys Leu Ile Pro Leu Pro Gly 
                485                 490                 495     

Arg Cys Val Glu Val Lys Arg Ala Arg Glu Ile Ile Glu Glu Asn Trp 
            500                 505                 510         

Gln Ile Leu Asn Ser Phe Pro Asp Gln Ala Ala Val Gln Ala Arg Gly 
        515                 520                 525             

Ala Phe Val Gln Glu Pro Gly Arg Glu Ala Ser Thr Ser Ala Gln Gly 
    530                 535                 540                 

<210>   648
<211>   1635
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   648
ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac cagccattgc gcgtcatgca       60

cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga tcgcgatgag ggacgtccac      120

atcgacaggc tcgtcgagat cgtcggcgag cggcgctgcc tgtggcgacc gcaccaggtg      180

aaggcgtacg cctgcgacgg ctacacggcc gaagaggggc tgccgcgcgc ggtggtcttc      240

ccggagtcga cggacgaggt ggcgcgcatc tgccgctatc tctacgagaa cgacattccg      300

tatcttccgc gcggcgcggg cacgggcctg tcgggcggcg ccacgccgac ggggggcgag      360

gtcgtcatca gcctcgcgcg catgaacaag ctcctcgccg tcgacttcga caacctgcgc      420

gccgtcgtgc agcctgggct cgtgaacctc acgctcacgc gccgggtctc gcacgcggac      480

tgctactacg cgcccgatcc gtccagccag tcggtctgca ccatcggcgg gaacttcgcg      540

gagaacgcgg gcggtagcca ctgcctgaag tacggcgtga ccacgaacca cgtggtcgcg      600

gccaaggtgg tgctgccgga tggcgacgtg atcgacgtcg gcgcgccgtt cggcgacgcg      660

ccggggtacg atctgctggg gcttctggtc ggctcggagg ggacgctcgg catcgcgacg      720

gagatcacgg tccgcatcct caaaaagccg caggcgctcc gcaccgcgct cgcctacttc      780

gatcgcgtcg ccgacgcgtc cgacacggtg acggacatca tcggggcggg catcatcccg      840

gccgccatcg agatgatgga tcagctcgcg atgcaggccg tcgacaagag caactatcat      900

gttggctatc cgacggacat cgaggcggtt ttgctcatcg aggtggacgg cctcgccgcg      960

ggcgtcgacg aggtgatggc gcgcgtggtg gaaatttgcc gccgccaccg cgtgcgcgag     1020

gtgcgggtgg cgcagtcgga cgccgagcgc gcgctctggt ggtccagccg caaaatggcg     1080

tttggcgcca tggggcgcat ctcgcccgac tacatcgtgc aggacggcgt gattccgcgc     1140

acgcgcctca ccgaggtgct gcagaagatc gacgaggtga gccggcgata cgggctgaag     1200

atcgcgaacg tgtttcacgc gggcgacggc aacctgcatc cgctcatcct gtacgacagc     1260

cgcgtgccgg gcgaggccga gcgcgcggtc agggccggat cggaggtgct gcgggcgtgc     1320

gtcgacgcgg gcgggagcat caccggcgag cacggcgtcg gcattgagaa gatcggcgaa     1380

atggcctata tgttttccga ggacgagatc catgcgcaac gcgcggtcaa gtcctgcttc     1440

gatccgaagg gcatcgtgaa cgctgggaag ctcattccgc tgcccggccg gtgcgtcgag     1500

gtgaagcggg cgcgcgagat catcgaggag aattggcaga ttctcaactc gttcccggat     1560

caggcggccg tgcaggcgcg gggcgccttt gtgcaggagc ccggcagaga agcatcgacg     1620

agcgcgcaag gatga                                                      1635


<210>   649
<211>   470
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   649
Ile Ala Thr Asn Asp Pro His Ile Gln Ala Leu Ala Arg Ile Val Gly 
                5                   10                  15      

Glu Gln Ala Ile Leu Tyr Arg Lys Glu Asp Leu Met Ala Tyr Asp Cys 
            20                  25                  30          

Asp Gly Phe Thr Val His Arg His Leu Pro Arg Ala Val Val Phe Pro 
        35                  40                  45              

Asn Ser Thr Glu Gln Val Ala Ala Val Val Lys Tyr Cys His Glu His 
    50                  55                  60                  

Asp Leu Pro Phe Leu Ala Arg Gly Ala Gly Thr Gly Leu Ser Gly Gly 
65                  70                  75                  80  

Ala Ile Pro Leu Asn Gly Glu Val Val Ile Ser Leu Thr Arg Met Lys 
                85                  90                  95      

Arg Leu Leu His Val Asp Leu Glu Asn Arg Arg Ala Val Val Glu Pro 
            100                 105                 110         

Gly Phe Val Asn Leu Lys Leu Thr Asn Ser Val Ala His Arg Gly Tyr 
        115                 120                 125             

Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Tyr Cys Cys Thr Ile Gly Gly 
    130                 135                 140                 

Asn Val Ala Glu Asn Ala Gly Gly Ala His Cys Leu Lys Tyr Gly Val 
145                 150                 155                 160 

Thr Thr Asn His Ile Leu Gly Leu Glu Val Val Leu Pro Asn Gly Glu 
                165                 170                 175     

Val Ile Glu Ile Gly Gly Asn Gly Val Pro Asp Pro Pro Gly Tyr Asp 
            180                 185                 190         

Leu Leu Gly Leu Leu Thr Gly Ser Glu Gly Thr Leu Gly Ile Val Thr 
        195                 200                 205             

Lys Ile Thr Val Arg Leu Leu Lys Asn Pro Glu Ala Lys Gln Thr Val 
    210                 215                 220                 

Leu Ala Tyr Phe Asp Glu Val Glu Asp Ala Ser Gln Thr Val Ser Asp 
225                 230                 235                 240 

Ile Ile Ser Ala Gly Ile Val Pro Ala Ala Leu Glu Met Met Asp Gln 
                245                 250                 255     

Thr Ala Ile Glu Ala Val Glu Ala Ala Ala Phe Pro Val Gly His Pro 
            260                 265                 270         

Lys Asp Ile Ala Ala Leu Leu Leu Ile Glu Val Asp Gly Ile Ser Ala 
        275                 280                 285             

Gly Ile Asp Glu Gln Ile Asn Asp Ile Leu Thr Ile Cys Arg Arg His 
    290                 295                 300                 

His Val Arg Glu Val Lys Val Ala Gln Ser Glu Glu Glu Arg Ala Arg 
305                 310                 315                 320 

Trp Trp Ala Asn Arg Lys Thr Gly Phe Gly Ala Met Gly Ala Ile Ser 
                325                 330                 335     

Pro Asp Tyr Leu Val Gln Asp Gly Val Ile Pro Arg Ser Arg Leu Pro 
            340                 345                 350         

Glu Val Leu Arg Glu Ile Ala Asp Ile Ser Arg Lys Tyr Gly Leu Arg 
        355                 360                 365             

Ile Ala Asn Ile Phe His Ala Gly Asp Gly Asn Leu His Pro Leu Val 
    370                 375                 380                 

Leu Phe Asp Ala Ser Lys Pro Gly Glu Thr Glu Arg Ala Leu Ala Ala 
385                 390                 395                 400 

Gly Ser Glu Cys Leu Lys Ala Cys Ala Ala Val Gly Gly Ser Ile Thr 
                405                 410                 415     

Gly Glu His Gly Val Gly Ile Glu Lys Lys Glu Glu Met Arg Phe Ile 
            420                 425                 430         

Phe Thr Asp Glu Glu Ile Leu Ala Gln Thr Ala Ile Arg Asp Val Phe 
        435                 440                 445             

Asn Pro Lys Asn Leu Leu Asn Ala Gly Lys Leu Phe Pro Thr Pro Glu 
    450                 455                 460                 

Arg Cys Val Glu Thr Lys 
465                 470 

<210>   650
<211>   477
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   650
Ile Ala Thr Asn Asp Pro His Ile Arg Ala Leu Ala Arg Ile Val Gly 
                5                   10                  15      

Glu Glu Ala Ile Leu Tyr Arg Lys Glu Asp Leu Ile Ala Tyr Asp Cys 
            20                  25                  30          

Asp Gly Phe Thr Val His Arg His Leu Pro Lys Ala Val Val Phe Pro 
        35                  40                  45              

Asn Ser Thr Glu Glu Val Ala Ala Val Val Lys Tyr Cys His Glu His 
    50                  55                  60                  

Glu Leu Pro Phe Leu Ala Arg Gly Ala Gly Thr Gly Leu Ser Gly Gly 
65                  70                  75                  80  

Ala Ile Pro Leu Asn Gly Glu Val Ile Ile Ser Leu Thr Arg Met Lys 
                85                  90                  95      

Arg Leu Leu His Val Asp Leu Glu Asn Arg Arg Ala Val Val Glu Pro 
            100                 105                 110         

Gly Phe Val Asn Leu Lys Leu Thr Asn Ser Val Ala His Arg Gly Tyr 
        115                 120                 125             

Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Tyr Cys Cys Thr Ile Gly Gly 
    130                 135                 140                 

Asn Val Ala Glu Asn Ala Gly Gly Ala His Cys Leu Lys Tyr Gly Val 
145                 150                 155                 160 

Thr Thr Asn His Ile Leu Gly Leu Glu Val Val Leu Pro Asp Gly Glu 
                165                 170                 175     

Val Ile Glu Ile Gly Gly Asn Gly Val Pro Asp Pro Pro Gly Tyr Asp 
            180                 185                 190         

Leu Leu Gly Leu Leu Thr Gly Ser Glu Gly Thr Leu Gly Ile Val Thr 
        195                 200                 205             

Lys Ile Thr Val Arg Leu Leu Lys Asn Pro Glu Ala Lys Gln Thr Val 
    210                 215                 220                 

Leu Ala Tyr Phe Asp Glu Val Glu Asp Ala Ser Gln Thr Val Ser Asp 
225                 230                 235                 240 

Ile Ile Ser Ala Gly Ile Val Pro Ala Ala Leu Glu Met Met Asp Gln 
                245                 250                 255     

Thr Ala Ile Glu Ala Val Glu Ala Ala Ala Phe Pro Val Gly His Pro 
            260                 265                 270         

Lys Asp Ile Ala Ala Leu Leu Leu Ile Glu Val Asp Gly Ile Ser Ala 
        275                 280                 285             

Gly Ile Ser Glu Gln Ile Asp Asp Ile Leu Thr Ile Cys Arg Arg His 
    290                 295                 300                 

His Val Arg Glu Val Lys Val Ala Glu Ser Glu Glu Glu Arg Ala Arg 
305                 310                 315                 320 

Trp Trp Ala Asn Arg Lys Thr Gly Phe Gly Ala Met Gly Ala Ile Ser 
                325                 330                 335     

Pro Asp Tyr Leu Val Gln Asp Gly Val Ile Pro Arg Ser Arg Leu Pro 
            340                 345                 350         

Glu Val Leu Arg Glu Ile Ala Asn Ile Ser Arg Lys Tyr Gly Leu Arg 
        355                 360                 365             

Ile Ala Asn Ile Phe His Ala Gly Asp Gly Asn Leu His Pro Leu Val 
    370                 375                 380                 

Leu Phe Asp Ala Ser Gln Pro Gly Glu Thr Glu Arg Ala Leu Ala Ala 
385                 390                 395                 400 

Gly Ser Glu Cys Leu Lys Ala Cys Ala Ala Val Gly Gly Ser Ile Thr 
                405                 410                 415     

Gly Glu His Gly Val Gly Leu Glu Lys Lys Glu Glu Met Arg Phe Ile 
            420                 425                 430         

Phe Ser Asp Glu Glu Ile Leu Ala Gln Thr Ala Ile Arg Asp Val Phe 
        435                 440                 445             

Asn Pro Lys Asn Leu Leu Asn Ala Gly Lys Leu Phe Pro Thr Pro Gly 
    450                 455                 460                 

Arg Cys Val Glu Thr Lys Gln Val Ser Ser Thr Val Lys 
465                 470                 475         

<210>   651
<211>   472
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   651
Ile Lys Thr Asn Asp Pro Asp Ile Leu Asn Leu Ala Lys Leu Val Asp 
                5                   10                  15      

Gly Pro Lys Ser Ile Leu Tyr Leu Lys Glu Asp Leu Ile Ala Tyr Asp 
            20                  25                  30          

Cys Asp Gly Phe Thr Ile His Lys His Leu Pro Lys Ala Val Val Phe 
        35                  40                  45              

Pro Lys Asn Thr Glu Glu Val Ala Lys Ile Val Asn Tyr Cys Ala Ser 
    50                  55                  60                  

His Asp Leu Pro Phe Leu Ala Arg Gly Ala Gly Thr Gly Leu Ser Gly 
65                  70                  75                  80  

Gly Ala Ile Pro Ile Asn Gly Glu Val Ile Ile Ser Met Val Arg Met 
                85                  90                  95      

Lys Arg Leu Ile Ser Val Asp Leu Glu Asn Arg Arg Ala Val Val Glu 
            100                 105                 110         

Pro Gly Tyr Val Asn Leu Lys Leu Thr Asn Met Ile Ala Asp Lys Gly 
        115                 120                 125             

Tyr Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Ser Cys Cys Thr Ile Gly 
    130                 135                 140                 

Gly Asn Val Ala Glu Asn Ala Gly Gly Ala His Cys Leu Lys Tyr Gly 
145                 150                 155                 160 

Val Thr Thr Asn His Ile Leu Gly Leu Glu Val Val Leu Pro Asn Gly 
                165                 170                 175     

Asp Ile Ile Asp Ile Asn Cys Glu Gly Ile Ala Asp Val Pro Gly Tyr 
            180                 185                 190         

Asp Leu Leu Gly Leu Leu Thr Gly Ser Glu Gly Thr Leu Gly Ile Val 
        195                 200                 205             

Thr Lys Ile Thr Val Arg Ile Leu Lys Asn Pro Glu Ala Lys Gln Thr 
    210                 215                 220                 

Val Leu Ala Tyr Phe Asp Glu Val Ser Asp Gly Ser Tyr Ala Val Ser 
225                 230                 235                 240 

Asp Ile Val Ser Ala Gly Ile Val Pro Ala Ala Leu Glu Met Met Asp 
                245                 250                 255     

Lys Thr Ala Ile Glu Gly Val Glu Ala Ala Ala Phe Pro Val Gly His 
            260                 265                 270         

Pro Arg Asp Ile Ala Ala Leu Leu Leu Ile Glu Val Asp Gly Ile Ser 
        275                 280                 285             

Ala Gly Ile Asp Glu Gln Ile Asn Gln Ile Leu Asp Ile Cys Lys Arg 
    290                 295                 300                 

Arg His Val Arg Glu Val Lys Val Ala Glu Asn Glu Gln Glu Arg Ala 
305                 310                 315                 320 

Arg Trp Trp Ala Asn Arg Lys Thr Gly Phe Gly Ala Met Gly Ala Ile 
                325                 330                 335     

Ser Ala Asp Tyr Leu Val Gln Asp Gly Val Ile Pro Arg Ser Lys Leu 
            340                 345                 350         

Pro Glu Val Leu Glu Arg Ile Asn Gln Ile Ser Glu Gln Phe Gly Leu 
        355                 360                 365             

Arg Ile Ala Asn Ile Phe His Ala Gly Asp Gly Asn Leu His Pro Leu 
    370                 375                 380                 

Val Leu Phe Asp Ala Arg Ile Pro Gly Glu Thr Glu Lys Ala Leu Glu 
385                 390                 395                 400 

Ala Gly Ser Ala Cys Leu Lys Ala Cys Ala Asp Val Gly Gly Ser Ile 
                405                 410                 415     

Thr Gly Glu His Gly Val Gly Ile Glu Lys Met Glu Glu Met Arg Phe 
            420                 425                 430         

Val Phe Asn Glu Glu Glu Leu Ala Ala Gln Thr Arg Ile Arg Glu Val 
        435                 440                 445             

Phe Asn Pro Asp Asn Leu Leu Asn Gly Gly Lys Leu Phe Pro Ser Pro 
    450                 455                 460                 

Gly Arg Cys Val Glu Val Lys Lys 
465                 470         

<210>   652
<211>   462
<212>   PRT
<213>   Gloeobacter violaceus PCC 7421

<400>   652
Gln Met Glu Gln Ile Val Gly Lys Ser Gly Val Val Trp Thr Pro Glu 
                5                   10                  15      

Glu Leu Leu Val Phe Glu Cys Asp Gly Leu Thr Ser Tyr Lys Gln Arg 
            20                  25                  30          

Pro Ala Leu Ala Val Leu Pro Arg Thr Thr Glu Glu Val Ser Arg Val 
        35                  40                  45              

Leu Ala Leu Cys Tyr Arg Glu Gly Leu Pro Phe Val Ala Arg Gly Ser 
    50                  55                  60                  

Gly Thr Gly Leu Ser Gly Gly Ala Leu Pro Val Glu Gly Cys Val Leu 
65                  70                  75                  80  

Val Val Thr Ala Arg Met Asn Arg Ile Leu Ala Val Asp Leu Asp Asn 
                85                  90                  95      

Arg Gln Val Val Val Gln Pro Gly Val Ile Asn Asn Trp Val Thr Gln 
            100                 105                 110         

Ala Val Ser Gly Ala Gly Phe Tyr Tyr Ala Pro Asp Pro Ser Ser Gln 
        115                 120                 125             

Ser Ile Cys Ser Ile Gly Gly Asn Val Ala Glu Asn Ser Gly Gly Val 
    130                 135                 140                 

His Cys Leu Lys Tyr Gly Val Thr Thr Asn His Val Leu Gly Leu Lys 
145                 150                 155                 160 

Leu Val Leu Pro Asp Gly Glu Val Val Asp Val Gly Gly Arg Val Pro 
                165                 170                 175     

Glu Thr Pro Gly Tyr Asp Leu Ala Gly Val Phe Val Gly Ser Glu Gly 
            180                 185                 190         

Thr Leu Gly Ile Ala Thr Glu Ile Thr Leu Arg Leu Leu Lys Ser Ala 
        195                 200                 205             

Glu Ser Ile Arg Val Leu Leu Ala Asp Phe Ala Ala Ile Glu Glu Ala 
    210                 215                 220                 

Gly Ala Ala Val Thr Ala Ile Ile Ala Ala Gly Ile Val Pro Gly Gly 
225                 230                 235                 240 

Met Glu Ile Met Asp Asn Leu Ser Ile Asn Ala Val Glu Asp Val Val 
                245                 250                 255     

Ala Thr Asp Cys Tyr Pro Arg Asp Ala Gly Ala Ile Leu Leu Val Glu 
            260                 265                 270         

Val Asp Gly Leu Ala Val Glu Val Glu Ala Ala Ser Ala Arg Val Glu 
        275                 280                 285             

Ala Leu Cys Leu Glu Ala Gly Ala Arg Ala Val Arg Thr Ala Thr Asp 
    290                 295                 300                 

Pro Ala Glu Arg Leu Lys Leu Trp Lys Gly Arg Lys Ala Ala Phe Ala 
305                 310                 315                 320 

Ala Met Gly Gln Arg Ala Pro Asn Tyr Tyr Val Gln Asp Gly Val Ile 
                325                 330                 335     

Pro Arg Thr Lys Leu Gln Phe Val Leu Gln Gln Ile Glu Leu Leu Ser 
            340                 345                 350         

Glu Lys His Gly Tyr Pro Val Ala Asn Val Phe His Ala Gly Asp Gly 
        355                 360                 365             

Asn Leu His Pro Leu Ile Leu Tyr Asp Gly Arg Ile Ala Gly Glu Leu 
    370                 375                 380                 

Glu Lys Val Glu Leu Leu Gly Gly Glu Ile Leu Lys Leu Cys Val Ala 
385                 390                 395                 400 

Val Gly Gly Ser Ile Ser Gly Glu His Gly Ile Gly Ala Glu Lys Arg 
                405                 410                 415     

Cys Tyr Met Ser Asp Met Phe Thr Pro Ala Asp Leu Glu Thr Met Gln 
            420                 425                 430         

Trp Val Arg Thr Val Phe Asp Pro Lys Gly Leu Ala Asn Pro Thr Lys 
        435                 440                 445             

Leu Phe Pro Thr Pro Arg Thr Cys Gly Glu Ala Ala Arg Ala 
    450                 455                 460         

<210>   653
<211>   465
<212>   PRT
<213>   Microcystis aeruginosa NIES-843

<400>   653
Ile Lys Gln Leu Glu Ala Ile Leu Gly Lys Asp Gly Val Ile Arg Arg 
                5                   10                  15      

Lys Asp Glu Leu Leu Thr Tyr Glu Cys Asp Gly Ile Thr Gly Tyr Arg 
            20                  25                  30          

Gln Arg Pro Ala Leu Val Val Leu Pro Arg Ser Thr Ala Glu Ile Ala 
        35                  40                  45              

Ala Val Val Lys Leu Cys His Asp Asn Glu Ile Ala Trp Val Ala Arg 
    50                  55                  60                  

Gly Ala Gly Thr Gly Leu Ser Gly Gly Ala Leu Pro Leu Glu Glu Gly 
65                  70                  75                  80  

Ile Leu Ile Val Thr Ala Arg Met Asn Gln Ile Leu Arg Val Asp Leu 
                85                  90                  95      

Asp Asn Gln Arg Val Val Val Gln Pro Gly Val Ile Asn Asn Trp Val 
            100                 105                 110         

Thr Gln Ala Val Ser Gly Ala Gly Phe Tyr Tyr Ala Pro Asp Pro Ser 
        115                 120                 125             

Ser Gln Ile Ile Cys Ser Ile Gly Gly Asn Val Ala Glu Asn Ser Gly 
    130                 135                 140                 

Gly Val His Cys Leu Lys Tyr Gly Val Thr Thr Asn His Val Met Gly 
145                 150                 155                 160 

Leu Lys Ile Val Leu Pro Asp Gly Ser Ile Ile Asp Val Gly Gly Ala 
                165                 170                 175     

Val Pro Glu Gln Pro Gly Tyr Asp Leu Thr Gly Leu Phe Val Gly Ser 
            180                 185                 190         

Glu Gly Thr Leu Gly Ile Ala Thr Glu Ile Thr Leu Arg Ile Leu Lys 
        195                 200                 205             

Thr Pro Glu Ser Ile Cys Val Leu Leu Ala Asp Phe Thr Ser Ile Glu 
    210                 215                 220                 

Ala Ala Gly Gln Ala Val Ala Asp Ile Ile Lys Ser Gly Met Ile Pro 
225                 230                 235                 240 

Ala Gly Met Glu Ile Met Asp Asn Leu Ser Ile Asn Ala Val Glu Asp 
                245                 250                 255     

Val Val Ala Thr Gly Cys Tyr Pro Arg Asp Ala Glu Ser Val Leu Leu 
            260                 265                 270         

Val Glu Leu Asp Gly Leu Gly Val Glu Val Thr Arg Asn Lys His Arg 
        275                 280                 285             

Val Ala Glu Ile Cys Arg Gln Asn Gly Ala Arg Asn Ile Thr Thr Ala 
    290                 295                 300                 

Asn Asp Ala Glu Thr Arg Leu Lys Leu Trp Lys Gly Arg Lys Ala Ala 
305                 310                 315                 320 

Phe Ala Ala Ala Gly Lys Ile Ser Pro Asn Tyr Phe Val Gln Asp Gly 
                325                 330                 335     

Val Ile Pro Arg Thr Gln Leu Val Tyr Val Leu Gln Glu Ile Lys Ala 
            340                 345                 350         

Leu Ser Glu Lys Tyr Gly Tyr Lys Ile Ala Asn Val Phe His Ala Gly 
        355                 360                 365             

Asp Gly Asn Leu His Pro Leu Ile Leu Tyr Asp Asn Lys Val Glu Gly 
    370                 375                 380                 

Ala Trp Glu Glu Val Glu Glu Leu Gly Gly Glu Ile Leu Lys Leu Cys 
385                 390                 395                 400 

Val Arg Val Gly Gly Ser Leu Ser Gly Glu His Gly Ile Gly Ile Asp 
                405                 410                 415     

Lys Asn Cys Tyr Met Pro Ala Met Phe Asn Glu Ile Asp Leu Glu Thr 
            420                 425                 430         

Met Gly Tyr Val Arg Asp Cys Phe Asn Pro Lys Gly Leu Ala Asn Pro 
        435                 440                 445             

Gly Lys Leu Phe Pro Thr Pro Arg Ser Cys Gly Glu Ala Ala Asn Ala 
    450                 455                 460                 

Lys 
465 

<210>   654
<211>   544
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   654
Met His Asp Ala Asp Pro Ala Arg Arg Gln Ala Gln Glu Pro Ala Ile 
                5                   10                  15      

Ala Arg His Ala His Gly Arg Ser Ala Arg Ser Arg Leu Pro Glu Gly 
            20                  25                  30          

Gly Ile Ala Met Arg Asp Val His Ile Asp Arg Leu Val Glu Ile Val 
        35                  40                  45              

Gly Glu Arg Arg Cys Leu Trp Arg Pro His Gln Val Lys Ala Tyr Ala 
    50                  55                  60                  

Cys Asp Gly Tyr Thr Ala Glu Glu Gly Leu Pro Arg Ala Val Val Phe 
65                  70                  75                  80  

Pro Glu Ser Thr Asp Glu Val Ala Arg Ile Cys Arg Tyr Leu Tyr Glu 
                85                  90                  95      

Asn Asp Ile Pro Tyr Leu Pro Arg Gly Ala Gly Thr Gly Leu Ser Gly 
            100                 105                 110         

Gly Ala Thr Pro Thr Gly Gly Glu Val Val Ile Ser Leu Ala Arg Met 
        115                 120                 125             

Asn Lys Leu Leu Ala Val Asp Phe Asp Asn Leu Arg Ala Val Val Gln 
    130                 135                 140                 

Pro Gly Leu Val Asn Leu Thr Leu Thr Arg Arg Val Ser His Ala Asp 
145                 150                 155                 160 

Cys Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Ser Val Cys Thr Ile Gly 
                165                 170                 175     

Gly Asn Phe Ala Glu Asn Ala Gly Gly Ser His Cys Leu Lys Tyr Gly 
            180                 185                 190         

Val Thr Thr Asn His Val Val Ala Ala Lys Val Val Leu Pro Asp Gly 
        195                 200                 205             

Asp Val Ile Asp Val Gly Ala Pro Phe Gly Asp Ala Pro Gly Tyr Asp 
    210                 215                 220                 

Leu Leu Gly Leu Leu Val Gly Ser Glu Gly Thr Leu Gly Ile Ala Thr 
225                 230                 235                 240 

Glu Ile Thr Val Arg Ile Leu Lys Lys Pro Gln Ala Leu Arg Thr Ala 
                245                 250                 255     

Leu Ala Tyr Phe Asp Arg Val Ala Asp Ala Ser Asp Thr Val Thr Asp 
            260                 265                 270         

Ile Ile Gly Ala Gly Ile Ile Pro Ala Ala Ile Glu Met Met Asp Gln 
        275                 280                 285             

Leu Ala Met Gln Ala Val Asp Lys Ser Asn Tyr His Val Gly Tyr Pro 
    290                 295                 300                 

Thr Asp Ile Glu Ala Val Leu Leu Ile Glu Val Asp Gly Leu Ala Ala 
305                 310                 315                 320 

Gly Val Asp Glu Val Met Ala Arg Val Ile Glu Ile Cys Arg Arg His 
                325                 330                 335     

Arg Val Arg Glu Val Arg Val Ala Gln Ser Asp Ala Glu Arg Ala Leu 
            340                 345                 350         

Trp Trp Ser Ser Arg Lys Met Ala Phe Gly Ala Met Gly Arg Ile Ser 
        355                 360                 365             

Pro Asp Tyr Ile Val Gln Asp Gly Val Ile Pro Arg Thr Arg Leu Thr 
    370                 375                 380                 

Glu Val Leu Gln Lys Ile Asp Glu Val Ser Arg Arg Tyr Gly Leu Lys 
385                 390                 395                 400 

Ile Ala Asn Val Phe His Ala Gly Asp Gly Asn Leu His Pro Leu Ile 
                405                 410                 415     

Leu Tyr Asp Ser Arg Val Pro Gly Glu Ala Glu Arg Ala Val Arg Ala 
            420                 425                 430         

Gly Ser Glu Val Leu Arg Ala Cys Val Asp Ala Gly Gly Ser Ile Thr 
        435                 440                 445             

Gly Glu His Gly Val Gly Ile Glu Lys Ile Gly Glu Met Ala Tyr Met 
    450                 455                 460                 

Phe Ser Glu Asp Glu Ile His Ala Gln Arg Ala Val Lys Ser Cys Phe 
465                 470                 475                 480 

Asp Pro Lys Gly Ile Val Asn Ala Gly Lys Leu Ile Pro Leu Pro Gly 
                485                 490                 495     

Arg Cys Val Glu Val Lys Arg Ala Arg Glu Ile Ile Glu Glu Asn Trp 
            500                 505                 510         

Gln Ile Leu Asn Ser Phe Pro Asp Gln Ala Ala Val Gln Ala Arg Gly 
        515                 520                 525             

Ala Phe Val Gln Glu Pro Gly Arg Glu Ala Ser Thr Ser Ala Gln Gly 
    530                 535                 540                 

<210>   655
<211>   544
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   655
Met His Asp Ala Asp Pro Ala Arg Arg Gln Ala Gln Glu Pro Ala Ile 
                5                   10                  15      

Ala Arg His Ala His Gly Arg Ser Ala Arg Ser Arg Leu Pro Glu Gly 
            20                  25                  30          

Gly Ile Ala Met Arg Asp Val His Ile Asp Arg Leu Val Glu Ile Val 
        35                  40                  45              

Gly Glu Arg Arg Cys Leu Trp Arg Pro His Gln Val Lys Ala Tyr Ala 
    50                  55                  60                  

Cys Asp Gly Tyr Thr Ala Glu Glu Gly Leu Pro Arg Ala Val Val Phe 
65                  70                  75                  80  

Pro Glu Ser Thr Asp Glu Val Ala Arg Ile Cys Arg Tyr Leu Tyr Glu 
                85                  90                  95      

Asn Asp Ile Pro Tyr Leu Pro Arg Gly Ala Gly Thr Gly Leu Ser Gly 
            100                 105                 110         

Gly Ala Thr Pro Thr Gly Gly Glu Val Val Ile Ser Leu Ala Arg Met 
        115                 120                 125             

Asn Lys Leu Leu Ala Val Asp Phe Asp Asn Leu Arg Ala Val Val Gln 
    130                 135                 140                 

Pro Gly Leu Val Asn Leu Thr Leu Thr Arg Arg Val Ser His Ala Asp 
145                 150                 155                 160 

Cys Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Ser Val Cys Thr Ile Gly 
                165                 170                 175     

Gly Asn Phe Ala Glu Asn Ala Gly Gly Ser His Cys Leu Lys Tyr Gly 
            180                 185                 190         

Val Thr Thr Asn His Val Val Ala Ala Lys Val Val Leu Pro Asp Gly 
        195                 200                 205             

Asp Val Ile Asp Val Gly Ala Pro Phe Gly Asp Ala Pro Gly Tyr Asp 
    210                 215                 220                 

Leu Leu Gly Leu Leu Val Gly Ser Glu Gly Thr Leu Gly Ile Ala Thr 
225                 230                 235                 240 

Glu Ile Thr Val Arg Ile Leu Lys Lys Pro Gln Ala Leu Arg Thr Ala 
                245                 250                 255     

Leu Ala Tyr Phe Asp Arg Val Ala Asp Ala Ser Asp Thr Val Thr Asp 
            260                 265                 270         

Ile Ile Gly Ala Gly Ile Ile Pro Ala Ala Ile Glu Met Met Asp Gln 
        275                 280                 285             

Leu Ala Met Gln Ala Val Asp Lys Ser Asn Tyr His Val Gly Tyr Pro 
    290                 295                 300                 

Thr Asp Ile Glu Ala Val Leu Leu Ile Glu Val Asp Gly Leu Ala Ala 
305                 310                 315                 320 

Gly Val Asp Glu Val Met Ala Arg Val Val Glu Ile Cys Arg Arg His 
                325                 330                 335     

Arg Val Arg Glu Val Lys Val Ala Gln Ser Asp Ala Glu Arg Ala Leu 
            340                 345                 350         

Trp Trp Ser Ser Arg Lys Met Ala Phe Gly Ala Met Gly Arg Ile Ser 
        355                 360                 365             

Pro Asp Tyr Ile Val Gln Asp Gly Val Ile Pro Arg Thr Arg Leu Thr 
    370                 375                 380                 

Glu Val Leu Gln Lys Ile Asp Glu Val Ser Arg Arg Tyr Gly Leu Lys 
385                 390                 395                 400 

Ile Ala Asn Val Phe His Ala Gly Asp Gly Asn Leu His Pro Leu Ile 
                405                 410                 415     

Leu Tyr Asp Ser Arg Val Pro Gly Glu Ala Glu Arg Ala Val Arg Ala 
            420                 425                 430         

Gly Ser Glu Val Leu Arg Ala Cys Val Asp Ala Gly Gly Ser Ile Thr 
        435                 440                 445             

Gly Glu His Gly Val Gly Ile Glu Lys Ile Gly Glu Met Ala Tyr Met 
    450                 455                 460                 

Phe Ser Glu Asp Glu Ile His Ala Gln Arg Ala Val Lys Ser Cys Phe 
465                 470                 475                 480 

Asp Pro Lys Gly Ile Val Asn Ala Gly Lys Leu Ile Pro Leu Pro Gly 
                485                 490                 495     

Arg Cys Val Glu Val Lys Arg Ala Arg Glu Ile Ile Glu Glu Asn Trp 
            500                 505                 510         

Gln Ile Leu Asn Ser Phe Pro Asp Gln Ala Ala Val Gln Ala Arg Gly 
        515                 520                 525             

Ala Phe Val Gln Glu Pro Gly Arg Glu Ala Ser Thr Ser Ala Gln Gly 
    530                 535                 540                 

<210>   656
<211>   544
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   656
Met His Asp Ala Asp Pro Ala Arg Arg Gln Ala Gln Glu Pro Ala Ile 
                5                   10                  15      

Ala Arg His Ala His Gly Arg Ser Ala Arg Ser Arg Leu Pro Glu Gly 
            20                  25                  30          

Gly Ile Ala Met Arg Asp Val His Ile Asp Arg Leu Val Glu Ile Val 
        35                  40                  45              

Gly Glu Arg Arg Cys Leu Trp Arg Pro His Gln Val Lys Ala Tyr Ala 
    50                  55                  60                  

Cys Asp Gly Tyr Thr Ala Glu Glu Gly Leu Pro Arg Ala Val Val Phe 
65                  70                  75                  80  

Pro Glu Ser Thr Asp Glu Val Ala Arg Ile Cys Arg Tyr Leu Tyr Glu 
                85                  90                  95      

Asn Asp Ile Pro Tyr Leu Pro Arg Gly Ala Gly Thr Gly Leu Ser Gly 
            100                 105                 110         

Gly Ala Thr Pro Thr Gly Gly Glu Val Val Ile Ser Leu Ala Arg Met 
        115                 120                 125             

Asn Lys Leu Leu Ala Val Asp Phe Asp Asn Leu Arg Ala Val Val Gln 
    130                 135                 140                 

Pro Gly Leu Val Asn Leu Thr Leu Thr Arg Arg Val Ser His Ala Asp 
145                 150                 155                 160 

Cys Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Ser Val Cys Thr Ile Gly 
                165                 170                 175     

Gly Asn Phe Ala Glu Asn Ala Gly Gly Ser His Cys Leu Lys Tyr Gly 
            180                 185                 190         

Val Thr Thr Asn His Val Val Ala Ala Lys Val Val Leu Pro Asp Gly 
        195                 200                 205             

Asp Val Ile Asp Val Gly Ala Pro Phe Gly Asp Ala Pro Gly Tyr Asp 
    210                 215                 220                 

Leu Leu Gly Leu Leu Val Gly Ser Glu Gly Thr Leu Gly Ile Ala Thr 
225                 230                 235                 240 

Glu Ile Thr Val Arg Ile Leu Lys Lys Pro Gln Ala Leu Arg Thr Ala 
                245                 250                 255     

Leu Ala Tyr Phe Asp Arg Val Ala Asp Ala Ser Asp Thr Val Thr Asp 
            260                 265                 270         

Ile Ile Gly Ala Gly Ile Ile Pro Ala Ala Ile Glu Met Met Asp Gln 
        275                 280                 285             

Leu Ala Met Gln Ala Val Asp Lys Ser Asn Tyr His Val Gly Tyr Pro 
    290                 295                 300                 

Thr Asp Ile Glu Ala Val Leu Leu Ile Glu Val Asp Gly Leu Ala Ala 
305                 310                 315                 320 

Gly Val Asp Glu Val Met Ala Arg Val Val Glu Ile Cys Arg Arg His 
                325                 330                 335     

Arg Val Arg Glu Val Arg Val Ala Gln Ser Asp Ala Glu Arg Ala Leu 
            340                 345                 350         

Trp Trp Ser Ser Arg Lys Met Ala Phe Gly Ala Met Gly Arg Ile Ser 
        355                 360                 365             

Pro Asp Tyr Ile Val Gln Asp Gly Val Ile Pro Arg Thr Arg Leu Thr 
    370                 375                 380                 

Glu Val Leu Gln Lys Ile Asp Glu Val Ser Arg Arg Tyr Gly Leu Lys 
385                 390                 395                 400 

Ile Ala Asn Val Phe His Ala Gly Asp Gly Asn Leu His Pro Leu Ile 
                405                 410                 415     

Leu Tyr Asp Ser Arg Val Pro Gly Glu Ala Glu Arg Ala Val Arg Ala 
            420                 425                 430         

Gly Ser Glu Val Leu Arg Ala Cys Val Asp Ala Gly Gly Ser Ile Thr 
        435                 440                 445             

Gly Glu His Gly Val Gly Ile Glu Lys Ile Gly Glu Met Ala Tyr Met 
    450                 455                 460                 

Phe Ser Glu Asp Glu Ile His Ala Gln Arg Ala Val Lys Ser Cys Phe 
465                 470                 475                 480 

Asp Pro Lys Gly Ile Val Asn Ala Gly Lys Leu Ile Pro Leu Pro Gly 
                485                 490                 495     

Arg Cys Val Glu Val Lys Arg Ala Arg Glu Ile Ile Glu Glu Asn Trp 
            500                 505                 510         

Gln Ile Leu Asn Ser Phe Pro Asp Asn Ala Ala Val Gln Ala Arg Gly 
        515                 520                 525             

Ala Phe Val Gln Glu Pro Gly Arg Glu Ala Ser Thr Ser Ala Gln Gly 
    530                 535                 540                 

<210>   657
<211>   544
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   657
Met His Asp Ala Asp Pro Ala Arg Arg Gln Ala Gln Glu Pro Ala Ile 
                5                   10                  15      

Ala Arg His Ala His Gly Arg Ser Ala Arg Ser Arg Leu Pro Glu Gly 
            20                  25                  30          

Gly Ile Ala Met Arg Asp Val His Ile Asp Arg Leu Val Glu Ile Val 
        35                  40                  45              

Gly Glu Arg Arg Cys Leu Trp Arg Pro His Gln Val Lys Ala Tyr Ala 
    50                  55                  60                  

Cys Asp Gly Tyr Thr Ala Glu Glu Gly Leu Pro Arg Ala Val Val Phe 
65                  70                  75                  80  

Pro Glu Ser Thr Asp Glu Val Ala Arg Ile Cys Arg Tyr Leu Tyr Glu 
                85                  90                  95      

Asn Asp Ile Pro Tyr Leu Pro Arg Gly Ala Gly Thr Gly Leu Ser Gly 
            100                 105                 110         

Gly Ala Thr Pro Thr Gly Gly Glu Val Val Ile Ser Leu Ala Arg Met 
        115                 120                 125             

Asn Lys Leu Leu Ala Val Asp Phe Asp Asn Leu Arg Ala Val Val Gln 
    130                 135                 140                 

Pro Gly Leu Val Asn Leu Thr Leu Thr Arg Arg Val Ser His Ala Asp 
145                 150                 155                 160 

Cys Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Ser Val Cys Thr Ile Gly 
                165                 170                 175     

Gly Asn Phe Ala Glu Asn Ala Gly Gly Ser His Cys Leu Lys Tyr Gly 
            180                 185                 190         

Val Thr Thr Asn His Val Val Ala Ala Lys Val Val Leu Pro Asp Gly 
        195                 200                 205             

Asp Val Ile Asp Val Gly Ala Pro Phe Gly Asp Ala Pro Gly Tyr Asp 
    210                 215                 220                 

Leu Leu Gly Leu Leu Val Gly Ser Glu Gly Thr Leu Gly Ile Ala Thr 
225                 230                 235                 240 

Glu Ile Thr Val Arg Ile Leu Lys Lys Pro Gln Ala Leu Arg Thr Ala 
                245                 250                 255     

Leu Ala Tyr Phe Asp Arg Val Ala Asp Ala Ser Asp Thr Val Thr Asp 
            260                 265                 270         

Ile Ile Gly Ala Gly Ile Ile Pro Ala Ala Ile Glu Met Met Asp Gln 
        275                 280                 285             

Leu Ala Met Gln Ala Val Asp Lys Ser Asn Tyr His Val Gly Tyr Pro 
    290                 295                 300                 

Thr Asp Ile Glu Ala Val Leu Leu Ile Glu Val Asp Gly Leu Ala Ala 
305                 310                 315                 320 

Gly Val Asp Glu Val Met Ala Arg Val Val Glu Ile Cys Arg Arg His 
                325                 330                 335     

Arg Val Arg Glu Val Arg Val Ala Asn Ser Asp Ala Glu Arg Ala Leu 
            340                 345                 350         

Trp Trp Ser Ser Arg Lys Met Ala Phe Gly Ala Met Gly Arg Ile Ser 
        355                 360                 365             

Pro Asp Tyr Ile Val Gln Asp Gly Val Ile Pro Arg Thr Arg Leu Thr 
    370                 375                 380                 

Glu Val Leu Gln Lys Ile Asp Glu Val Ser Arg Arg Tyr Gly Leu Lys 
385                 390                 395                 400 

Ile Ala Asn Val Phe His Ala Gly Asp Gly Asn Leu His Pro Leu Ile 
                405                 410                 415     

Leu Tyr Asp Ser Arg Val Pro Gly Glu Ala Glu Arg Ala Val Arg Ala 
            420                 425                 430         

Gly Ser Glu Val Leu Arg Ala Cys Val Asp Ala Gly Gly Ser Ile Thr 
        435                 440                 445             

Gly Glu His Gly Val Gly Ile Glu Lys Ile Gly Glu Met Ala Tyr Met 
    450                 455                 460                 

Phe Ser Glu Asp Glu Ile His Ala Gln Arg Ala Val Lys Ser Cys Phe 
465                 470                 475                 480 

Asp Pro Lys Gly Ile Val Asn Ala Gly Lys Leu Ile Pro Leu Pro Gly 
                485                 490                 495     

Arg Cys Val Glu Val Lys Arg Ala Arg Glu Ile Ile Glu Glu Asn Trp 
            500                 505                 510         

Gln Ile Leu Asn Ser Phe Pro Asp Gln Ala Ala Val Gln Ala Arg Gly 
        515                 520                 525             

Ala Phe Val Gln Glu Pro Gly Arg Glu Ala Ser Thr Ser Ala Gln Gly 
    530                 535                 540                 

<210>   658
<211>   544
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   658
Met His Asp Ala Asp Pro Ala Arg Arg Gln Ala Gln Glu Pro Ala Ile 
                5                   10                  15      

Ala Arg His Ala His Gly Arg Ser Ala Arg Ser Arg Leu Pro Glu Gly 
            20                  25                  30          

Gly Leu Ala Met Arg Asp Val His Ile Asp Arg Leu Val Glu Ile Val 
        35                  40                  45              

Gly Glu Arg Arg Cys Leu Trp Arg Pro His Gln Val Lys Ala Tyr Ala 
    50                  55                  60                  

Cys Asp Gly Tyr Thr Ala Glu Glu Gly Leu Pro Arg Ala Val Val Phe 
65                  70                  75                  80  

Pro Glu Ser Thr Asp Glu Val Ala Arg Ile Cys Arg Tyr Leu Tyr Glu 
                85                  90                  95      

Asn Asp Ile Pro Tyr Leu Pro Arg Gly Ala Gly Thr Gly Leu Ser Gly 
            100                 105                 110         

Gly Ala Thr Pro Thr Gly Gly Glu Val Val Ile Ser Leu Ala Arg Met 
        115                 120                 125             

Asn Lys Leu Leu Ala Val Asp Phe Asp Asn Leu Arg Ala Val Val Gln 
    130                 135                 140                 

Pro Gly Leu Val Asn Leu Thr Leu Thr Arg Arg Val Ser His Ala Asp 
145                 150                 155                 160 

Cys Tyr Tyr Ala Pro Asp Pro Ser Ser Gln Ser Val Cys Thr Ile Gly 
                165                 170                 175     

Gly Asn Phe Ala Glu Asn Ala Gly Gly Ser His Cys Leu Lys Tyr Gly 
            180                 185                 190         

Val Thr Thr Asn His Val Val Ala Ala Lys Val Val Leu Pro Asp Gly 
        195                 200                 205             

Asp Val Ile Asp Val Gly Ala Pro Phe Gly Asp Ala Pro Gly Tyr Asp 
    210                 215                 220                 

Leu Leu Gly Leu Leu Val Gly Ser Glu Gly Thr Leu Gly Ile Ala Thr 
225                 230                 235                 240 

Glu Ile Thr Val Arg Ile Leu Lys Lys Pro Gln Ala Leu Arg Thr Ala 
                245                 250                 255     

Leu Ala Tyr Phe Asp Arg Val Ala Asp Ala Ser Asp Thr Val Thr Asp 
            260                 265                 270         

Ile Ile Gly Ala Gly Ile Ile Pro Ala Ala Ile Glu Met Met Asp Gln 
        275                 280                 285             

Leu Ala Met Gln Ala Val Asp Lys Ser Asn Tyr His Val Gly Tyr Pro 
    290                 295                 300                 

Thr Asp Ile Glu Ala Val Leu Leu Ile Glu Val Asp Gly Leu Ala Ala 
305                 310                 315                 320 

Gly Val Asp Glu Val Met Ala Arg Val Val Glu Ile Cys Arg Arg His 
                325                 330                 335     

Arg Val Arg Glu Val Arg Val Ala Gln Ser Asp Ala Glu Arg Ala Leu 
            340                 345                 350         

Trp Trp Ser Ser Arg Lys Met Ala Phe Gly Ala Met Gly Arg Ile Ser 
        355                 360                 365             

Pro Asp Tyr Ile Val Gln Asp Gly Val Ile Pro Arg Thr Arg Leu Thr 
    370                 375                 380                 

Glu Val Leu Gln Lys Ile Asp Glu Val Ser Arg Arg Tyr Gly Leu Lys 
385                 390                 395                 400 

Ile Ala Asn Val Phe His Ala Gly Asp Gly Asn Leu His Pro Leu Ile 
                405                 410                 415     

Leu Tyr Asp Ser Arg Val Pro Gly Glu Ala Glu Arg Ala Val Arg Ala 
            420                 425                 430         

Gly Ser Glu Val Leu Arg Ala Cys Val Asp Ala Gly Gly Ser Ile Thr 
        435                 440                 445             

Gly Glu His Gly Val Gly Ile Glu Lys Ile Gly Glu Met Ala Tyr Met 
    450                 455                 460                 

Phe Ser Glu Asp Glu Ile His Ala Gln Arg Ala Val Lys Ser Cys Phe 
465                 470                 475                 480 

Asp Pro Lys Gly Ile Val Asn Ala Gly Lys Leu Ile Pro Leu Pro Gly 
                485                 490                 495     

Arg Cys Val Glu Val Lys Arg Ala Arg Glu Ile Ile Glu Glu Asn Trp 
            500                 505                 510         

Gln Ile Leu Asn Ser Phe Pro Asp Gln Ala Ala Val Gln Ala Arg Gly 
        515                 520                 525             

Ala Phe Val Gln Glu Pro Gly Arg Glu Ala Ser Thr Ser Ala Gln Gly 
    530                 535                 540                 

<210>   659
<211>   1635
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   659
ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac cagccattgc gcgtcatgca       60

cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga tcgcgatgag ggacgtccac      120

atcgacaggc tcgtcgagat cgtcggcgag cggcgctgcc tgtggcgacc gcaccaggtg      180

aaggcgtacg cctgcgacgg ctacacggcc gaagaggggc tgccgcgcgc ggtggtcttc      240

ccggagtcga cggacgaggt ggcgcgcatc tgccgctatc tctacgagaa cgacattccg      300

tatcttccgc gcggcgcggg cacgggcctg tcgggcggcg ccacgccgac ggggggcgag      360

gtcgtcatca gcctcgcgcg catgaacaag ctcctcgccg tcgacttcga caacctgcgc      420

gccgtcgtgc agcctgggct cgtgaacctc acgctcacgc gccgggtctc gcacgcggac      480

tgctactacg cgcccgatcc gtccagccag tcggtctgca ccatcggcgg gaacttcgcg      540

gagaacgcgg gcggtagcca ctgcctgaag tacggcgtga ccacgaacca cgtggtcgcg      600

gccaaggtgg tgctgccgga tggcgacgtg atcgacgtcg gcgcgccgtt cggcgacgcg      660

ccggggtacg atctgctggg gcttctggtc ggctcggagg ggacgctcgg catcgcgacg      720

gagatcacgg tccgcatcct caaaaagccg caggcgctcc gcaccgcgct cgcctacttc      780

gatcgcgtcg ccgacgcgtc cgacacggtg acggacatca tcggggcggg catcatcccg      840

gccgccatcg agatgatgga tcagctcgcg atgcaggccg tcgacaagag caactatcat      900

gttggctatc cgacggacat cgaggcggtt ttgctcatcg aggtggacgg cctcgccgcg      960

ggcgtcgacg aggtgatggc gcgcgtgatt gaaatttgcc gccgccaccg cgtgcgcgag     1020

gtgcgggtgg cgcagtcgga cgccgagcgc gcgctctggt ggtccagccg caaaatggcg     1080

tttggcgcca tggggcgcat ctcgcccgac tacatcgtgc aggacggcgt gattccgcgc     1140

acgcgcctca ccgaggtgct gcagaagatc gacgaggtga gccggcgata cgggctgaag     1200

atcgcgaacg tgtttcacgc gggcgacggc aacctgcatc cgctcatcct gtacgacagc     1260

cgcgtgccgg gcgaggccga gcgcgcggtc agggccggat cggaggtgct gcgggcgtgc     1320

gtcgacgcgg gcgggagcat caccggcgag cacggcgtcg gcattgagaa gatcggcgaa     1380

atggcctata tgttttccga ggacgagatc catgcgcaac gcgcggtcaa gtcctgcttc     1440

gatccgaagg gcatcgtgaa cgctgggaag ctcattccgc tgcccggccg gtgcgtcgag     1500

gtgaagcggg cgcgcgagat catcgaggag aattggcaga ttctcaactc gttcccggat     1560

caggcggccg tgcaggcgcg gggcgccttt gtgcaggagc ccggcagaga agcatcgacg     1620

agcgcgcaag gatga                                                      1635


<210>   660
<211>   1635
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   660
ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac cagccattgc gcgtcatgca       60

cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga tcgcgatgag ggacgtccac      120

atcgacaggc tcgtcgagat cgtcggcgag cggcgctgcc tgtggcgacc gcaccaggtg      180

aaggcgtacg cctgcgacgg ctacacggcc gaagaggggc tgccgcgcgc ggtggtcttc      240

ccggagtcga cggacgaggt ggcgcgcatc tgccgctatc tctacgagaa cgacattccg      300

tatcttccgc gcggcgcggg cacgggcctg tcgggcggcg ccacgccgac ggggggcgag      360

gtcgtcatca gcctcgcgcg catgaacaag ctcctcgccg tcgacttcga caacctgcgc      420

gccgtcgtgc agcctgggct cgtgaacctc acgctcacgc gccgggtctc gcacgcggac      480

tgctactacg cgcccgatcc gtccagccag tcggtctgca ccatcggcgg gaacttcgcg      540

gagaacgcgg gcggtagcca ctgcctgaag tacggcgtga ccacgaacca cgtggtcgcg      600

gccaaggtgg tgctgccgga tggcgacgtg atcgacgtcg gcgcgccgtt cggcgacgcg      660

ccggggtacg atctgctggg gcttctggtc ggctcggagg ggacgctcgg catcgcgacg      720

gagatcacgg tccgcatcct caaaaagccg caggcgctcc gcaccgcgct cgcctacttc      780

gatcgcgtcg ccgacgcgtc cgacacggtg acggacatca tcggggcggg catcatcccg      840

gccgccatcg agatgatgga tcagctcgcg atgcaggccg tcgacaagag caactatcat      900

gttggctatc cgacggacat cgaggcggtt ttgctcatcg aggtggacgg cctcgccgcg      960

ggcgtcgacg aggtgatggc gcgcgtggtg gaaatttgcc gccgccaccg cgtgcgcgag     1020

gtgaaagtgg cgcagtcgga cgccgagcgc gcgctctggt ggtccagccg caaaatggcg     1080

tttggcgcca tggggcgcat ctcgcccgac tacatcgtgc aggacggcgt gattccgcgc     1140

acgcgcctca ccgaggtgct gcagaagatc gacgaggtga gccggcgata cgggctgaag     1200

atcgcgaacg tgtttcacgc gggcgacggc aacctgcatc cgctcatcct gtacgacagc     1260

cgcgtgccgg gcgaggccga gcgcgcggtc agggccggat cggaggtgct gcgggcgtgc     1320

gtcgacgcgg gcgggagcat caccggcgag cacggcgtcg gcattgagaa gatcggcgaa     1380

atggcctata tgttttccga ggacgagatc catgcgcaac gcgcggtcaa gtcctgcttc     1440

gatccgaagg gcatcgtgaa cgctgggaag ctcattccgc tgcccggccg gtgcgtcgag     1500

gtgaagcggg cgcgcgagat catcgaggag aattggcaga ttctcaactc gttcccggat     1560

caggcggccg tgcaggcgcg gggcgccttt gtgcaggagc ccggcagaga agcatcgacg     1620

agcgcgcaag gatga                                                      1635


<210>   661
<211>   1635
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   661
ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac cagccattgc gcgtcatgca       60

cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga tcgcgatgag ggacgtccac      120

atcgacaggc tcgtcgagat cgtcggcgag cggcgctgcc tgtggcgacc gcaccaggtg      180

aaggcgtacg cctgcgacgg ctacacggcc gaagaggggc tgccgcgcgc ggtggtcttc      240

ccggagtcga cggacgaggt ggcgcgcatc tgccgctatc tctacgagaa cgacattccg      300

tatcttccgc gcggcgcggg cacgggcctg tcgggcggcg ccacgccgac ggggggcgag      360

gtcgtcatca gcctcgcgcg catgaacaag ctcctcgccg tcgacttcga caacctgcgc      420

gccgtcgtgc agcctgggct cgtgaacctc acgctcacgc gccgggtctc gcacgcggac      480

tgctactacg cgcccgatcc gtccagccag tcggtctgca ccatcggcgg gaacttcgcg      540

gagaacgcgg gcggtagcca ctgcctgaag tacggcgtga ccacgaacca cgtggtcgcg      600

gccaaggtgg tgctgccgga tggcgacgtg atcgacgtcg gcgcgccgtt cggcgacgcg      660

ccggggtacg atctgctggg gcttctggtc ggctcggagg ggacgctcgg catcgcgacg      720

gagatcacgg tccgcatcct caaaaagccg caggcgctcc gcaccgcgct cgcctacttc      780

gatcgcgtcg ccgacgcgtc cgacacggtg acggacatca tcggggcggg catcatcccg      840

gccgccatcg agatgatgga tcagctcgcg atgcaggccg tcgacaagag caactatcat      900

gttggctatc cgacggacat cgaggcggtt ttgctcatcg aggtggacgg cctcgccgcg      960

ggcgtcgacg aggtgatggc gcgcgtggtg gaaatttgcc gccgccaccg cgtgcgcgag     1020

gtgcgggtgg cgcagtcgga cgccgagcgc gcgctctggt ggtccagccg caaaatggcg     1080

tttggcgcca tggggcgcat ctcgcccgac tacatcgtgc aggacggcgt gattccgcgc     1140

acgcgcctca ccgaggtgct gcagaagatc gacgaggtga gccggcgata cgggctgaag     1200

atcgcgaacg tgtttcacgc gggcgacggc aacctgcatc cgctcatcct gtacgacagc     1260

cgcgtgccgg gcgaggccga gcgcgcggtc agggccggat cggaggtgct gcgggcgtgc     1320

gtcgacgcgg gcgggagcat caccggcgag cacggcgtcg gcattgagaa gatcggcgaa     1380

atggcctata tgttttccga ggacgagatc catgcgcaac gcgcggtcaa gtcctgcttc     1440

gatccgaagg gcatcgtgaa cgctgggaag ctcattccgc tgcccggccg gtgcgtcgag     1500

gtgaagcggg cgcgcgagat catcgaggag aattggcaga ttctcaactc gttcccggat     1560

aatgcggccg tgcaggcgcg gggcgccttt gtgcaggagc ccggcagaga agcatcgacg     1620

agcgcgcaag gatga                                                      1635


<210>   662
<211>   1635
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   662
ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac cagccattgc gcgtcatgca       60

cacggtcgaa gtgctcgatc tcgcctaccg gagggaggga tcgcgatgag ggacgtccac      120

atcgacaggc tcgtcgagat cgtcggcgag cggcgctgcc tgtggcgacc gcaccaggtg      180

aaggcgtacg cctgcgacgg ctacacggcc gaagaggggc tgccgcgcgc ggtggtcttc      240

ccggagtcga cggacgaggt ggcgcgcatc tgccgctatc tctacgagaa cgacattccg      300

tatcttccgc gcggcgcggg cacgggcctg tcgggcggcg ccacgccgac ggggggcgag      360

gtcgtcatca gcctcgcgcg catgaacaag ctcctcgccg tcgacttcga caacctgcgc      420

gccgtcgtgc agcctgggct cgtgaacctc acgctcacgc gccgggtctc gcacgcggac      480

tgctactacg cgcccgatcc gtccagccag tcggtctgca ccatcggcgg gaacttcgcg      540

gagaacgcgg gcggtagcca ctgcctgaag tacggcgtga ccacgaacca cgtggtcgcg      600

gccaaggtgg tgctgccgga tggcgacgtg atcgacgtcg gcgcgccgtt cggcgacgcg      660

ccggggtacg atctgctggg gcttctggtc ggctcggagg ggacgctcgg catcgcgacg      720

gagatcacgg tccgcatcct caaaaagccg caggcgctcc gcaccgcgct cgcctacttc      780

gatcgcgtcg ccgacgcgtc cgacacggtg acggacatca tcggggcggg catcatcccg      840

gccgccatcg agatgatgga tcagctcgcg atgcaggccg tcgacaagag caactatcat      900

gttggctatc cgacggacat cgaggcggtt ttgctcatcg aggtggacgg cctcgccgcg      960

ggcgtcgacg aggtgatggc gcgcgtggtg gaaatttgcc gccgccaccg cgtgcgcgag     1020

gtgcgggtgg cgaattcgga cgccgagcgc gcgctctggt ggtccagccg caaaatggcg     1080

tttggcgcca tggggcgcat ctcgcccgac tacatcgtgc aggacggcgt gattccgcgc     1140

acgcgcctca ccgaggtgct gcagaagatc gacgaggtga gccggcgata cgggctgaag     1200

atcgcgaacg tgtttcacgc gggcgacggc aacctgcatc cgctcatcct gtacgacagc     1260

cgcgtgccgg gcgaggccga gcgcgcggtc agggccggat cggaggtgct gcgggcgtgc     1320

gtcgacgcgg gcgggagcat caccggcgag cacggcgtcg gcattgagaa gatcggcgaa     1380

atggcctata tgttttccga ggacgagatc catgcgcaac gcgcggtcaa gtcctgcttc     1440

gatccgaagg gcatcgtgaa cgctgggaag ctcattccgc tgcccggccg gtgcgtcgag     1500

gtgaagcggg cgcgcgagat catcgaggag aattggcaga ttctcaactc gttcccggat     1560

caggcggccg tgcaggcgcg gggcgccttt gtgcaggagc ccggcagaga agcatcgacg     1620

agcgcgcaag gatga                                                      1635


<210>   663
<211>   1635
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   663
ttgcatgatg cagatccggc tcggcgtcaa gcgcaggaac cagccattgc gcgtcatgca       60

cacggtcgaa gtgctcgatc tcgcctaccg gagggagggt tagcgatgag ggacgtccac      120

atcgacaggc tcgtcgagat cgtcggcgag cggcgctgcc tgtggcgacc gcaccaggtg      180

aaggcgtacg cctgcgacgg ctacacggcc gaagaggggc tgccgcgcgc ggtggtcttc      240

ccggagtcga cggacgaggt ggcgcgcatc tgccgctatc tctacgagaa cgacattccg      300

tatcttccgc gcggcgcggg cacgggcctg tcgggcggcg ccacgccgac ggggggcgag      360

gtcgtcatca gcctcgcgcg catgaacaag ctcctcgccg tcgacttcga caacctgcgc      420

gccgtcgtgc agcctgggct cgtgaacctc acgctcacgc gccgggtctc gcacgcggac      480

tgctactacg cgcccgatcc gtccagccag tcggtctgca ccatcggcgg gaacttcgcg      540

gagaacgcgg gcggtagcca ctgcctgaag tacggcgtga ccacgaacca cgtggtcgcg      600

gccaaggtgg tgctgccgga tggcgacgtg atcgacgtcg gcgcgccgtt cggcgacgcg      660

ccggggtacg atctgctggg gcttctggtc ggctcggagg ggacgctcgg catcgcgacg      720

gagatcacgg tccgcatcct caaaaagccg caggcgctcc gcaccgcgct cgcctacttc      780

gatcgcgtcg ccgacgcgtc cgacacggtg acggacatca tcggggcggg catcatcccg      840

gccgccatcg agatgatgga tcagctcgcg atgcaggccg tcgacaagag caactatcat      900

gttggctatc cgacggacat cgaggcggtt ttgctcatcg aggtggacgg cctcgccgcg      960

ggcgtcgacg aggtgatggc gcgcgtggtg gaaatttgcc gccgccaccg cgtgcgcgag     1020

gtgcgggtgg cgcagtcgga cgccgagcgc gcgctctggt ggtccagccg caaaatggcg     1080

tttggcgcca tggggcgcat ctcgcccgac tacatcgtgc aggacggcgt gattccgcgc     1140

acgcgcctca ccgaggtgct gcagaagatc gacgaggtga gccggcgata cgggctgaag     1200

atcgcgaacg tgtttcacgc gggcgacggc aacctgcatc cgctcatcct gtacgacagc     1260

cgcgtgccgg gcgaggccga gcgcgcggtc agggccggat cggaggtgct gcgggcgtgc     1320

gtcgacgcgg gcgggagcat caccggcgag cacggcgtcg gcattgagaa gatcggcgaa     1380

atggcctata tgttttccga ggacgagatc catgcgcaac gcgcggtcaa gtcctgcttc     1440

gatccgaagg gcatcgtgaa cgctgggaag ctcattccgc tgcccggccg gtgcgtcgag     1500

gtgaagcggg cgcgcgagat catcgaggag aattggcaga ttctcaactc gttcccggat     1560

caggcggccg tgcaggcgcg gggcgccttt gtgcaggagc ccggcagaga agcatcgacg     1620

agcgcgcaag gatga                                                      1635


<210>   664
<211>   534
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   664
Met Ala Gly Ser Tyr Ala Cys Pro Gln Gly Val Gln Ile Thr Gly Glu 
                5                   10                  15      

Tyr Arg Pro Glu Phe Ala Glu Ile Leu Thr Thr Asp Ala Leu Gln Phe 
            20                  25                  30          

Ile Ala Glu Leu Glu Arg Arg Phe Gly Pro Arg Arg Asp Glu Leu Leu 
        35                  40                  45              

Arg Leu Arg Lys Glu Arg Asp Glu Arg Leu Leu Ala Gly Glu Trp Pro 
    50                  55                  60                  

Asp Phe Leu Pro Glu Thr Lys Glu Ile Arg Glu Ser Glu Trp Thr Val 
65                  70                  75                  80  

Gly Pro Ile Pro Ala Asp Leu Gln Asp Arg Arg Val Glu Ile Thr Gly 
                85                  90                  95      

Pro Ser Ser Asp Arg Lys Met Val Ile Asn Ala Leu Asn Ser Gly Ala 
            100                 105                 110         

Lys Cys Phe Met Ala Asp Phe Glu Asp Ala Cys Ala Pro Ser Trp Glu 
        115                 120                 125             

Asn Val Val Gln Gly Gln Ile Asn Met Arg Asp Ala Val Arg Arg Thr 
    130                 135                 140                 

Ile Glu Tyr Thr Ser Pro Glu Gly Lys His Tyr Lys Leu Asn Asp Glu 
145                 150                 155                 160 

Val Ala Val Leu Ile Val Arg Pro Arg Gly Trp His Leu Pro Glu Lys 
                165                 170                 175     

His Ile Arg Val Asp Gly Arg Val Ala Thr Gly Ala Leu Val Asp Phe 
            180                 185                 190         

Gly Leu Tyr Phe Tyr His Asn Ala Lys Glu Leu Leu Ala Arg Gly Thr 
        195                 200                 205             

Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu Ser His Leu Glu Ala Arg 
    210                 215                 220                 

Leu Trp Asn Asp Val Phe Asn Tyr Ala Gln Asp Ala Leu Gly Ile Pro 
225                 230                 235                 240 

Arg Gly Thr Ile Lys Ala Thr Val Leu Ile Glu Thr Ile Leu Ala Thr 
                245                 250                 255     

Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu Arg Asp His Ala Ala Gly 
            260                 265                 270         

Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe Ser Tyr Ile Lys Lys Phe 
        275                 280                 285             

Arg Asn His Pro Glu Val Ile Leu Pro Asp Arg Ala Gln Val Thr Met 
    290                 295                 300                 

Thr Val Pro Phe Met Arg Ala Tyr Thr Leu Leu Thr Ile Arg Thr Cys 
305                 310                 315                 320 

His Arg Arg Lys Ala Phe Ala Met Gly Gly Met Ala Ala Gln Ile Pro 
                325                 330                 335     

Ile Lys Asn Asp Pro Lys Ala Asn Glu Glu Ala Leu Ala Lys Val Arg 
            340                 345                 350         

Ala Asp Lys Glu Arg Glu Ala Gln Asp Gly His Asp Gly Thr Trp Val 
        355                 360                 365             

Ala His Pro Gly Leu Val Pro Val Ala Met Glu Val Phe Asn Arg Leu 
    370                 375                 380                 

Met Pro Thr Pro Asn Gln Leu His Arg Leu Arg Glu Asp Val Gln Val 
385                 390                 395                 400 

Thr Ala Ala Asp Leu Val Ala Val Pro Gln Gly Thr Ile Thr Glu Gly 
                405                 410                 415     

Gly Leu Arg Thr Asn Val Ala Val Ala Leu Arg Tyr Ile Glu Ala Trp 
            420                 425                 430         

Leu Arg Gly Ser Gly Ala Val Pro Ile Phe Asn Leu Met Glu Asp Ala 
        435                 440                 445             

Ala Thr Ala Glu Ile Ser Arg Ala Gln Ile Trp Gln Trp Ile His His 
    450                 455                 460                 

Pro Lys Gly Val Leu Asp Asp Gly Arg Lys Val Thr Val Glu Leu Phe 
465                 470                 475                 480 

Arg Gln Ile Leu Glu Glu Glu Leu Arg Lys Leu Lys Asp Glu Ile Gly 
                485                 490                 495     

Glu Glu Ala Tyr Ala Gln Ser Lys Phe Pro Leu Ala Ala Glu Leu Leu 
            500                 505                 510         

Asp Asp Ile Ser Thr Lys Asp Asp Phe Val Asp Phe Leu Thr Leu Pro 
        515                 520                 525             

Gly Tyr Glu His Leu Ala 
    530                 

<210>   665
<211>   1605
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   665
atggcgggat cgtacgcttg cccacagggc gtgcaaatca cgggcgaata caggcctgag       60

ttcgccgaaa tcctcacgac ggacgcgctt caattcatcg cggagcttga gcgccgcttc      120

ggtccgaggc gggacgaact gcttcgcctg cgcaaggagc gggacgagcg gttgctcgcg      180

ggcgaatggc cggacttctt gccggagacc aaggagattc gcgagagcga gtggacggtc      240

gggcccatcc ccgcggatct gcaggatcgg cgcgtggaaa tcacgggccc gagttcggac      300

cggaagatgg tcatcaacgc cttgaactcg ggcgccaagt gcttcatggc ggactttgag      360

gacgcctgcg caccgtcctg ggagaacgtc gtgcagggtc agatcaacat gcgggacgca      420

gttcgccgca ccatcgaata cacgagcccc gaggggaagc actacaagct gaatgacgaa      480

gttgcggtgc tcatcgtgcg cccgcgcggc tggcacctgc ccgagaagca catccgggtg      540

gacggccggg tggccacggg cgcgctcgtc gacttcgggc tttacttcta ccacaatgcc      600

aaggagcttt tggcgcgcgg caccgggccc tacttctacc tgccgaagat ggagagccac      660

ctcgaggcga ggctgtggaa cgacgtgttc aactacgccc aggacgcgct cggcatcccg      720

cgcggcacca tcaaggccac tgtgctcatc gagaccatcc tcgcgacgtt cgagatggac      780

gagatcctgt atgagctgcg cgatcacgcc gcggggctca actgcggccg ctgggactac      840

atcttcagct acatcaagaa gttccgcaat cacccggagg tcatcctgcc tgaccgggcg      900

caggtgacga tgacggtgcc gttcatgcgc gcgtacaccc tgctcaccat ccgcacgtgc      960

catcggcgca aggcgttcgc gatgggcggc atggcggcgc agatccccat caagaacgac     1020

ccgaaggcga acgaggaggc gctcgccaag gtgcgcgcgg acaaggagcg cgaggcgcag     1080

gacggccacg acggcacctg ggtggcgcac ccgggtctcg tgcccgtggc gatggaggtg     1140

ttcaatcgcc tcatgcccac gcccaaccag ttgcaccgcc tgcgcgagga cgtccaggtc     1200

accgcggccg atctcgtcgc ggtcccgcag ggcaccatca ccgaaggcgg cctgcgcacc     1260

aacgtcgccg tggcgcttcg ctacatcgag gcttggctgc gcggttccgg cgcggtgccc     1320

atcttcaacc tgatggaaga cgcggcgacg gcggagatct cccgcgcgca gatctggcag     1380

tggatccatc acccgaaagg cgtcctcgac gacggccgca aggtgacggt ggagctgttc     1440

cggcagattc tcgaagagga gttgcgcaag ttgaaggacg agatcggcga ggaggcgtac     1500

gcacagagca agttcccgct cgcggccgaa cttctcgacg acatctcgac gaaggacgac     1560

ttcgtcgact tcctgacgct gccgggttac gagcacctgg cgtga                     1605


<210>   666
<211>   525
<212>   PRT
<213>   Chloroflexus aurantiacus J-10-fl

<400>   666
Pro Ala Gly Val Thr Ile Thr Ala Pro Ile Thr Pro Ala Tyr Ala Glu 
                5                   10                  15      

Ile Leu Thr Pro Glu Ala Leu Glu Phe Leu Ala Thr Leu His Arg Arg 
            20                  25                  30          

Phe Asn Thr Arg Arg Leu Glu Leu Leu Ala Arg Arg Ala Glu Arg Gln 
        35                  40                  45              

Arg Ala Ile Asp Ala Gly Glu Arg Pro Asp Phe Leu Pro Glu Thr Ala 
    50                  55                  60                  

His Ile Arg Glu Ser Glu Trp Thr Ile Ala Pro Ile Pro Pro Gln Ile 
65                  70                  75                  80  

Gln Asp Arg Arg Val Glu Ile Thr Gly Pro Val Asp Arg Lys Met Ile 
                85                  90                  95      

Ile Asn Ala Leu Asn Ser Gly Ala Lys Val Phe Met Ala Asp Phe Glu 
            100                 105                 110         

Asp Ala Asn Thr Pro Thr Trp Gln Asn Gln Val Glu Gly Gln Ile Asn 
        115                 120                 125             

Leu Arg Asp Ala Leu Arg Arg Thr Ile Thr Tyr Thr Ser Pro Glu Gly 
    130                 135                 140                 

Lys His Tyr Ala Leu Asn Asn Asn Pro Ala Ile Leu Phe Val Arg Pro 
145                 150                 155                 160 

Arg Gly Trp His Leu Asn Glu Lys His Met Leu Val Asp Gly Glu Pro 
                165                 170                 175     

Ile Ser Gly Ala Ile Phe Asp Phe Gly Leu Tyr Phe Phe His Asn Ala 
            180                 185                 190         

Gln Thr Ala Ile Asp Val Gln Gly Gly Pro Tyr Phe Tyr Leu Pro Lys 
        195                 200                 205             

Met Glu Ser His Leu Glu Ala Arg Leu Trp Asn Asp Ile Phe Val Leu 
    210                 215                 220                 

Ala Gln Glu Leu Arg Gly Ile Pro Gln Gly Thr Ile Lys Ala Thr Val 
225                 230                 235                 240 

Leu Ile Glu Thr Ile Leu Ala Ala Phe Glu Met Asp Glu Ile Leu Tyr 
                245                 250                 255     

Glu Leu Arg Asn His Ser Ala Gly Leu Asn Cys Gly Arg Trp Asp Tyr 
            260                 265                 270         

Ile Phe Ser Cys Ile Lys Lys Phe Arg Asn Asp Pro Asn Phe Cys Leu 
        275                 280                 285             

Ala Asp Arg Ala Leu Val Thr Met Thr Thr His Phe Met Arg Ser Tyr 
    290                 295                 300                 

Ser Leu Leu Ala Ile Lys Thr Cys His Arg Arg Gly Ala His Ala Met 
305                 310                 315                 320 

Gly Gly Met Ala Ala Gln Ile Pro Ile Lys Asn Asp Pro Val Ala Asn 
                325                 330                 335     

Glu Ala Ala Leu Ala Lys Val Arg Ala Asp Lys Glu Arg Glu Ala Ser 
            340                 345                 350         

Asp Gly His Asp Gly Thr Trp Val Ala His Pro Gly Leu Val Pro Val 
        355                 360                 365             

Ala Met Glu Val Phe Asp Arg Leu Met Pro Thr Pro Asn Gln Ile Asn 
    370                 375                 380                 

Arg Gln Arg Asp Asp Val Gln Val Thr Ala Ala Asp Leu Leu Ala Phe 
385                 390                 395                 400 

Gly Pro Glu Lys Pro Ile Thr Glu Gln Gly Met Arg Leu Asn Ile Asn 
                405                 410                 415     

Val Gly Ile Gln Tyr Leu Gly Ala Trp Leu Ala Gly Asn Gly Cys Val 
            420                 425                 430         

Pro Val Phe Asn Leu Met Glu Asp Ala Ala Thr Ala Glu Ile Ser Arg 
        435                 440                 445             

Ala Gln Ile Trp Gln Trp Ile Arg Ser Pro Lys Gly Val Leu Glu Asp 
    450                 455                 460                 

Gly Arg Lys Val Thr Val Glu Leu Phe Arg Gln Met Leu Pro Glu Glu 
465                 470                 475                 480 

Leu His Lys Val Arg Glu Ile Leu Gly Pro Ala Tyr Glu Asp Gly Arg 
                485                 490                 495     

Tyr Glu Glu Ala Ala Glu Leu Phe Asp Glu Ile Thr Thr Asp Pro Glu 
            500                 505                 510         

Phe Val Glu Phe Leu Thr Leu Pro Ala Tyr Glu Arg Ile 
        515                 520                 525 

<210>   667
<211>   525
<212>   PRT
<213>   Chloroflexus aggregans DSM 9485

<400>   667
Pro Ala Gly Val Thr Ile Thr Ala Pro Ile Thr Pro Glu Tyr Ala Glu 
                5                   10                  15      

Ile Leu Thr Pro Glu Ala Leu Glu Phe Leu Ala Thr Leu His Arg Arg 
            20                  25                  30          

Phe Asn Ala Arg Arg Leu Glu Leu Leu Ala Arg Arg Ala Glu Arg Gln 
        35                  40                  45              

Arg Ala Ile Asp Ala Gly Glu Arg Pro Asp Phe Leu Pro Glu Thr Ala 
    50                  55                  60                  

His Ile Arg Glu Ser Asp Trp Thr Ile Ala Pro Phe Pro Pro Gln Leu 
65                  70                  75                  80  

Asn Asp Arg Arg Val Glu Ile Thr Gly Pro Val Asp Arg Lys Met Ile 
                85                  90                  95      

Ile Asn Ala Leu Asn Ser Gly Ala Lys Val Phe Met Ala Asp Phe Glu 
            100                 105                 110         

Asp Ala Asn Thr Pro Thr Trp Gln Asn Gln Ile Glu Gly Gln Ile Asn 
        115                 120                 125             

Leu Arg Asp Ala Leu Arg Arg Thr Ile Thr Tyr Thr Ser Pro Glu Gly 
    130                 135                 140                 

Lys Tyr Tyr Ala Leu Asn Pro Asn Pro Ala Ile Leu Phe Val Arg Pro 
145                 150                 155                 160 

Arg Gly Trp His Leu Pro Glu Lys His Met Leu Val Asp Gly Glu Pro 
                165                 170                 175     

Ile Ala Gly Ala Ile Phe Asp Phe Gly Leu Tyr Phe Phe His Asn Ala 
            180                 185                 190         

Gln Thr Ala Ile Glu Val Gln Gly Gly Pro Tyr Phe Tyr Leu Pro Lys 
        195                 200                 205             

Leu Glu Ser His Leu Glu Ala Arg Leu Trp Asn Asp Ile Phe Val Leu 
    210                 215                 220                 

Ala Gln Glu Leu Arg Gly Ile Pro Arg Gly Thr Ile Lys Ala Thr Val 
225                 230                 235                 240 

Leu Ile Glu Thr Ile Leu Ala Ala Phe Glu Met Asp Glu Ile Leu Tyr 
                245                 250                 255     

Glu Leu Arg Glu His Ser Ala Gly Leu Asn Cys Gly Arg Trp Asp Tyr 
            260                 265                 270         

Ile Phe Ser Cys Ile Lys Lys Phe Arg Asn Asp Pro Asn Phe Cys Leu 
        275                 280                 285             

Ala Asp Arg Val Leu Val Thr Met Thr Thr His Phe Met Arg Ser Tyr 
    290                 295                 300                 

Ser Leu Leu Ala Ile Lys Thr Cys His Arg Arg Gly Ala His Ala Met 
305                 310                 315                 320 

Gly Gly Met Ala Ala Gln Ile Pro Ile Lys Asn Asp Pro Val Ala Asn 
                325                 330                 335     

Glu Ala Ala Leu Ala Lys Val Arg Ala Asp Lys Glu Arg Glu Ala Asn 
            340                 345                 350         

Asp Gly His Asp Gly Thr Trp Val Ala His Pro Gly Leu Val Pro Val 
        355                 360                 365             

Ala Met Glu Val Phe Asp Arg Leu Met Pro Thr Pro Asn Gln Ile Asn 
    370                 375                 380                 

Arg Gln Arg Asp Asp Val His Val Thr Ala Ala Asp Leu Leu Ala Phe 
385                 390                 395                 400 

Gly Pro Ser Glu Pro Ile Thr Glu Gln Gly Leu Arg Leu Asn Ile Asn 
                405                 410                 415     

Val Gly Ile Gln Tyr Leu Gly Ala Trp Leu Ala Gly Asn Gly Cys Val 
            420                 425                 430         

Pro Val Phe Asn Leu Met Glu Asp Ala Ala Thr Ala Glu Ile Ser Arg 
        435                 440                 445             

Ala Gln Ile Trp Gln Trp Ile Arg Ser Pro Lys Gly Val Leu Ala Asp 
    450                 455                 460                 

Gly Arg Lys Val Thr Val Glu Leu Phe Arg Gln Met Leu Pro Glu Glu 
465                 470                 475                 480 

Leu Ala Lys Val Arg Glu Ile Leu Gly Pro Ala Tyr Glu Asp Gly Arg 
                485                 490                 495     

Tyr Gly Glu Ala Ala Glu Leu Phe Asp Glu Ile Thr Thr Asp Pro Asn 
            500                 505                 510         

Phe Val Glu Phe Leu Thr Leu Pro Ala Tyr Asp Arg Ile 
        515                 520                 525 

<210>   668
<211>   524
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   668
Gly Ile Thr Val Thr Gly Ser Ile His Asp Gly Tyr Asp Asp Ile Leu 
                5                   10                  15      

Thr Pro Glu Ala Leu Gln Phe Leu Glu Gln Leu Glu Arg His Phe Gly 
            20                  25                  30          

Glu Arg Arg Arg Glu Leu Leu Ala Tyr Arg Lys Lys Arg Asp Glu Glu 
        35                  40                  45              

Ile Lys Ser Gly Lys Leu Pro His Phe Leu Glu Glu Thr Ala Ser Ile 
    50                  55                  60                  

Arg Glu Ser Asp Trp Thr Ile Ala Pro Leu Pro Glu Asp Leu Gln Asp 
65                  70                  75                  80  

Arg Arg Val Glu Ile Thr Gly Pro Val Asp Arg Lys Met Val Ile Asn 
                85                  90                  95      

Ala Leu Asn Ser Gly Ala Lys Ile Phe Met Ala Cys Phe Glu Asp Ala 
            100                 105                 110         

Thr Ser Pro Thr Trp Glu Asn Ile Ile Glu Gly Gln Ile His Leu Arg 
        115                 120                 125             

Asp Ala Val Asn Arg Thr Ile Thr Phe Thr Gly Pro Asn Gly Lys Glu 
    130                 135                 140                 

Tyr Lys Leu Ala Asp His Pro Ala Val Leu Ile Val Arg Pro Arg Gly 
145                 150                 155                 160 

Trp His Leu Glu Glu Lys His Ile Leu Val Asp Gly Lys Pro Ile Ser 
                165                 170                 175     

Gly Ser Leu Thr Asp Phe Gly Leu Tyr Phe Phe His Asn Ala Arg Arg 
            180                 185                 190         

Leu Leu Glu Asn Ser Thr Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu 
        195                 200                 205             

Ser His Leu Glu Ala Arg Leu Trp Asn Asp Val Phe Ile Phe Ala Gln 
    210                 215                 220                 

Lys Tyr Ile Gly Ile Pro Lys Gly Thr Ile Lys Ala Thr Val Leu Ile 
225                 230                 235                 240 

Glu Thr Ile Met Ala Ala Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu 
                245                 250                 255     

Lys Glu His Ser Ala Gly Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe 
            260                 265                 270         

Ser Tyr Ile Lys Lys Leu Arg Thr Asn Pro Gln Phe Ile Thr Pro Asp 
        275                 280                 285             

Arg Ser Leu Val Thr Met Thr Val Pro Phe Met Arg Ala Tyr Ser Leu 
    290                 295                 300                 

Leu Thr Ile Lys Thr Cys His Arg Arg Asn Ala Pro Ala Ile Gly Gly 
305                 310                 315                 320 

Met Ala Ala Gln Ile Pro Val Lys Asp Asp Pro Ala Lys Asn Glu Glu 
                325                 330                 335     

Ala Phe Gln Lys Val Arg Ala Asp Lys Glu Arg Glu Ala Arg Asp Gly 
            340                 345                 350         

His Asp Gly Thr Trp Val Ala His Pro Gly Leu Val Pro Val Ala Leu 
        355                 360                 365             

Glu Ala Phe Asn Lys Glu Met Pro Glu Pro Asn Gln Ile His Ser Gly 
    370                 375                 380                 

Lys Gln Met Asp Phe Thr Ala Thr Ala Asp Asp Leu Leu Ala Val Pro 
385                 390                 395                 400 

Gln Gly Glu Ile Thr Glu Lys Gly Ile Arg Glu Asn Ile Tyr Ala Gly 
                405                 410                 415     

Ile Gln Tyr Ile Glu Ser Trp Leu Arg Gly Arg Gly Ala Val Pro Ile 
            420                 425                 430         

Ser Asn Leu Met Glu Asp Ala Ala Thr Ala Glu Ile Ser Arg Thr Gln 
        435                 440                 445             

Leu Trp His Trp Ile Arg His Pro Lys Gly Val Leu Gln Asp Gly Arg 
    450                 455                 460                 

Lys Val Thr Ile Glu Leu Tyr Glu Gln Ile Lys Ala Glu Glu Leu Glu 
465                 470                 475                 480 

Arg Ile Arg Arg Glu Ile Gly Glu Glu Tyr Tyr Arg Ala Gly Arg Phe 
                485                 490                 495     

Glu Glu Ala Val Ala Leu Phe Asp Arg Leu Val Lys Glu Asp Glu Phe 
            500                 505                 510         

Ile Glu Phe Leu Thr Leu Pro Ala Tyr Glu Leu Leu 
        515                 520                 

<210>   669
<211>   522
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   669
Val Thr Leu Ala Gly Glu Leu Leu Pro Ser Tyr Asn Glu Ile Leu Thr 
                5                   10                  15      

Pro Glu Ala Leu Thr Phe Leu Lys Glu Leu His Glu Asn Phe Asn Glu 
            20                  25                  30          

Arg Arg Ile Gln Leu Leu Lys Lys Arg Glu Glu Lys Gln Lys Arg Ile 
        35                  40                  45              

Asp Ala Gly Glu Phe Pro Asn Phe Leu Pro Glu Thr Ala His Ile Arg 
    50                  55                  60                  

Ala Gly Asn Trp Thr Ile Ala Pro Leu Pro Arg Asp Leu Glu Asp Arg 
65                  70                  75                  80  

Arg Val Glu Ile Thr Gly Pro Val Asp Arg Lys Met Ile Ile Asn Ala 
                85                  90                  95      

Leu Asn Ser Gly Ala His Leu Phe Met Ala Asp Phe Glu Asp Ser Ser 
            100                 105                 110         

Ser Pro Thr Trp Lys Asn Ile Ile Glu Gly Gln Ile Asn Leu Arg Asp 
        115                 120                 125             

Ala Ala Lys Gly Thr Ile Ser Tyr Lys Ser Pro Ser Gly Lys Glu Tyr 
    130                 135                 140                 

Arg Leu Gly Asp Gln Thr Ala Val Leu Ile Val Arg Pro Arg Gly Trp 
145                 150                 155                 160 

His Leu Glu Glu Lys His Met Gln Val Asp Gly Lys Arg Met Ser Gly 
                165                 170                 175     

Ser Leu Val Asp Phe Gly Leu Tyr Phe Phe His Asn Ala Lys Thr Leu 
            180                 185                 190         

Ile Glu Lys Gly Ser Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu Ser 
        195                 200                 205             

Tyr Leu Glu Ala Arg Leu Trp Asn Asp Val Phe Val Phe Ala Gln Lys 
    210                 215                 220                 

Tyr Val Gly Ile Pro Asn Gly Thr Ile Lys Ala Thr Val Leu Leu Glu 
225                 230                 235                 240 

Thr Ile His Ala Ala Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu Arg 
                245                 250                 255     

Asp His Ser Ala Gly Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe Ser 
            260                 265                 270         

Phe Leu Lys Cys Phe Arg Asn His Lys Ala Phe Leu Leu Pro Asp Arg 
        275                 280                 285             

Ala Gln Val Thr Met Thr Val Pro Phe Met Arg Ala Tyr Ser Leu Lys 
    290                 295                 300                 

Val Ile Gln Thr Cys His Arg Arg Asn Ala Pro Ala Met Gly Gly Met 
305                 310                 315                 320 

Ala Ala Gln Ile Pro Ile Lys Asn Asn Pro Glu Ala Asn Glu Ile Ala 
                325                 330                 335     

Phe Glu Lys Val Arg Val Asp Lys Glu Arg Glu Ala Leu Asp Gly His 
            340                 345                 350         

Asp Gly Thr Trp Val Ala His Pro Gly Leu Val Pro Val Ala Met Glu 
        355                 360                 365             

Val Phe Asn His Ile Met Lys Thr Pro Asn Gln Ile Phe Arg Lys Arg 
    370                 375                 380                 

Glu Glu Leu His Val Thr Glu Lys Asp Leu Leu Glu Val Pro Met Gly 
385                 390                 395                 400 

Thr Ile Thr Glu Glu Gly Leu Arg Met Asn Ile Ser Val Gly Ile Gln 
                405                 410                 415     

Tyr Ile Ala Ser Trp Leu Ser Gly Arg Gly Ala Ala Pro Ile Tyr Asn 
            420                 425                 430         

Leu Met Glu Asp Ala Ala Thr Ala Glu Ile Ser Arg Ala Gln Val Trp 
        435                 440                 445             

Gln Trp Ile Arg His Glu Glu Gly Lys Leu Asn Asp Gly Arg Lys Val 
    450                 455                 460                 

Thr Phe Ala Leu Val Glu Gln Leu Lys Ala Glu Glu Leu Ala Lys Ile 
465                 470                 475                 480 

Glu Lys Glu Ile Gly Lys Glu Ser Phe Glu Lys Gly Arg Phe Val Glu 
                485                 490                 495     

Ala Thr Lys Leu Phe Thr Asp Leu Val Arg Lys Asp Glu Phe Glu Pro 
            500                 505                 510         

Phe Leu Thr Leu Pro Gly Tyr Glu Ile Leu 
        515                 520         

<210>   670
<211>   522
<212>   PRT
<213>   Bacillus cereus E33L

<400>   670
Val Thr Leu Val Gly Glu Met Leu Pro Ala Tyr Asn Glu Ile Leu Thr 
                5                   10                  15      

Pro Glu Ala Leu Ser Phe Leu Lys Glu Leu His Gly Asn Phe Asn Glu 
            20                  25                  30          

Arg Arg Ile Glu Leu Leu Gln Lys Arg Ala Glu Lys Gln Lys Arg Ile 
        35                  40                  45              

Asp Ala Gly Glu Phe Pro Lys Phe Leu Glu Glu Thr Lys His Ile Arg 
    50                  55                  60                  

Glu Ala Asp Trp Thr Ile Ala Lys Leu Pro Lys Asp Leu Glu Asp Arg 
65                  70                  75                  80  

Arg Val Glu Ile Thr Gly Pro Val Asp Arg Lys Met Val Ile Asn Ala 
                85                  90                  95      

Leu Asn Ser Gly Ala His Leu Phe Met Ala Asp Phe Glu Asp Ser Asn 
            100                 105                 110         

Ser Pro Thr Trp Glu Asn Ala Ile Glu Gly Gln Ile Asn Leu Arg Asp 
        115                 120                 125             

Ala Val Arg Gly Thr Ile Ser His Lys Asn Glu Asn Gly Lys Glu Tyr 
    130                 135                 140                 

Arg Leu Asn Ser Lys Thr Ala Val Leu Ile Val Arg Pro Arg Gly Trp 
145                 150                 155                 160 

His Leu Glu Glu Lys His Met Gln Val Asp Gly Lys Asn Met Ser Gly 
                165                 170                 175     

Ser Leu Val Asp Phe Gly Leu Tyr Phe Phe His Asn Ala Lys Ala Leu 
            180                 185                 190         

Leu Glu Lys Gly Ser Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu Ser 
        195                 200                 205             

Tyr Leu Glu Ala Arg Leu Trp Asn Asp Val Phe Val Phe Ala Gln Lys 
    210                 215                 220                 

Tyr Ile Gly Ile Pro Asn Gly Thr Ile Lys Ala Thr Val Leu Leu Glu 
225                 230                 235                 240 

Thr Ile His Ala Ser Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu Lys 
                245                 250                 255     

Asp His Ser Ala Gly Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe Ser 
            260                 265                 270         

Phe Leu Lys Ala Phe Arg Asn His Asn Glu Phe Leu Leu Pro Asp Arg 
        275                 280                 285             

Ala Gln Val Thr Met Thr Ala Pro Phe Met Arg Ala Tyr Ser Leu Lys 
    290                 295                 300                 

Val Ile Gln Thr Cys His Arg Arg Asn Ala Pro Ala Ile Gly Gly Met 
305                 310                 315                 320 

Ala Ala Gln Ile Pro Ile Lys Asn Asn Pro Lys Ala Asn Glu Ala Ala 
                325                 330                 335     

Phe Glu Lys Val Arg Ala Asp Lys Glu Arg Glu Ala Leu Asp Gly His 
            340                 345                 350         

Asp Gly Thr Trp Val Ala His Pro Gly Leu Val Pro Val Ala Met Glu 
        355                 360                 365             

Val Phe Asn His Ile Met Lys Thr Pro Asn Gln Ile Phe Arg Lys Arg 
    370                 375                 380                 

Glu Glu Ile His Val Thr Glu Lys Asp Leu Leu Glu Val Pro Val Gly 
385                 390                 395                 400 

Thr Ile Thr Glu Glu Gly Leu Arg Met Asn Ile Ser Val Gly Ile Gln 
                405                 410                 415     

Tyr Ile Ala Ser Trp Leu Ser Gly Arg Gly Ala Ala Pro Ile Tyr Asn 
            420                 425                 430         

Leu Met Glu Asp Ala Ala Thr Ala Glu Ile Ser Arg Ala Gln Val Trp 
        435                 440                 445             

Gln Trp Ile Arg His Glu Gly Gly Lys Leu Asn Asp Gly Arg Asn Ile 
    450                 455                 460                 

Thr Leu Glu Leu Met Glu Glu Leu Lys Glu Glu Glu Leu Glu Lys Ile 
465                 470                 475                 480 

Glu Arg Glu Ile Gly Lys Glu Ala Phe Lys Lys Gly Arg Phe Gln Glu 
                485                 490                 495     

Ala Thr Thr Leu Phe Thr Asn Leu Val Arg Asn Asp Glu Phe Val Pro 
            500                 505                 510         

Phe Leu Thr Leu Pro Gly Tyr Glu Ile Leu 
        515                 520         

<210>   671
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   671
Met Ala Gly Ser Tyr Ala Cys Pro Gln Gly Val Gln Ile Thr Gly Glu 
                5                   10                  15      

Tyr Arg Pro Glu Phe Ala Glu Ile Leu Thr Thr Asp Ala Leu Gln Phe 
            20                  25                  30          

Ile Ala Glu Leu Glu Arg Arg Phe Gly Pro Arg Arg Asp Glu Leu Leu 
        35                  40                  45              

Arg Leu Arg Lys Glu Arg Asp Glu Arg Leu Leu Ala Gly Glu Trp Pro 
    50                  55                  60                  

Asp Phe Leu Pro Glu Thr Lys Glu Ile Arg Glu Ser Glu Trp Thr Val 
65                  70                  75                  80  

Gly Pro Ile Pro Ala Asp Leu Gln Asp Arg Arg Val Glu Ile Thr Gly 
                85                  90                  95      

Pro Ser Ser Asp Arg Lys Met Val Ile Asn Ala Leu Asn Ser Gly Ala 
            100                 105                 110         

Lys Cys Phe Met Ala Asp Phe Glu Asp Ala Cys Ala Pro Ser Trp Glu 
        115                 120                 125             

Asn Val Val Gln Gly Gln Ile Asn Met Arg Asp Ala Val Arg Arg Thr 
    130                 135                 140                 

Ile Glu Tyr Thr Ser Pro Glu Gly Lys His Tyr Lys Leu Asn Asp Glu 
145                 150                 155                 160 

Val Ala Val Leu Ile Val Arg Pro Arg Gly Trp His Leu Pro Glu Lys 
                165                 170                 175     

His Ile Arg Val Asp Gly Arg Val Ala Thr Gly Ala Leu Val Asp Phe 
            180                 185                 190         

Gly Leu Tyr Phe Tyr His Asn Ala Lys Glu Leu Leu Ala Arg Gly Thr 
        195                 200                 205             

Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu Ser His Leu Glu Ala Arg 
    210                 215                 220                 

Leu Trp Asn Asp Val Phe Asn Tyr Ala Gln Asp Ala Leu Gly Ile Pro 
225                 230                 235                 240 

Arg Gly Thr Ile Lys Ala Thr Val Leu Ile Glu Thr Ile Leu Ala Thr 
                245                 250                 255     

Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu Arg Asp His Ala Ala Gly 
            260                 265                 270         

Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe Ser Tyr Ile Lys Lys Phe 
        275                 280                 285             

Arg Asn His Pro Glu Val Ile Leu Pro Asp Arg Ala Gln Val Thr Met 
    290                 295                 300                 

Thr Val Pro Phe Met Arg Ala Tyr Thr Leu Leu Thr Ile Arg Thr Cys 
305                 310                 315                 320 

His Arg Arg Lys Ala Phe Ala Met Gly Gly Met Ala Ala Gln Ile Pro 
                325                 330                 335     

Ile Lys Asn Asp Pro Lys Ala Asn Glu Glu Ala Leu Ala Lys Val Arg 
            340                 345                 350         

Ala Asp Lys Glu Arg Glu Ala Gln Asp Gly His Asp Gly Thr Trp Val 
        355                 360                 365             

Ala His Pro Gly Leu Val Pro Val Ala Met Glu Val Phe Asn Arg Leu 
    370                 375                 380                 

Met Pro Thr Pro Asn Gln Leu His Arg Leu Arg Glu Asp Val Gln Val 
385                 390                 395                 400 

Thr Ala Ala Asp Leu Val Ala Val Pro Gln Gly Thr Ile Thr Glu Gly 
                405                 410                 415     

Gly Leu Arg Thr Asn Val Ala Val Ala Leu Arg Tyr Ile Glu Ala Trp 
            420                 425                 430         

Leu Arg Gly Ser Gly Ala Val Pro Ile Phe Asn Leu Met Glu Asp Ala 
        435                 440                 445             

Ala Thr Ala Glu Ile Ser Arg Ala Gln Ile Trp Gln Trp Ile His His 
    450                 455                 460                 

Pro Lys Gly Val Leu Asp Asp Gly Arg Lys Val Thr Val Glu Leu Phe 
465                 470                 475                 480 

Arg Gln Ile Leu Glu Glu Glu Leu Arg Lys Leu Lys Asp Glu Ile Gly 
                485                 490                 495     

Glu Glu Ala Tyr Ala Gln Ser Lys Phe Pro Leu Ala Ala Glu Leu Leu 
            500                 505                 510         

Asp Glu Ile Ser Thr Lys Asp Asp Phe Val Asp Phe Leu Thr Leu Pro 
        515                 520                 525             

Gly Tyr Glu His Leu Ala 
    530                 

<210>   672
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   672
Met Ala Gly Ser Tyr Ala Cys Pro Gln Gly Val Gln Ile Thr Gly Asp 
                5                   10                  15      

Tyr Arg Pro Glu Phe Ala Glu Ile Leu Thr Thr Asp Ala Leu Gln Phe 
            20                  25                  30          

Ile Ala Glu Leu Glu Arg Arg Phe Gly Pro Arg Arg Asp Glu Leu Leu 
        35                  40                  45              

Arg Leu Arg Lys Glu Arg Asp Glu Arg Leu Leu Ala Gly Glu Trp Pro 
    50                  55                  60                  

Asp Phe Leu Pro Glu Thr Lys Glu Ile Arg Glu Ser Glu Trp Thr Val 
65                  70                  75                  80  

Gly Pro Ile Pro Ala Asp Leu Gln Asp Arg Arg Val Glu Ile Thr Gly 
                85                  90                  95      

Pro Ser Ser Asp Arg Lys Met Val Ile Asn Ala Leu Asn Ser Gly Ala 
            100                 105                 110         

Lys Cys Phe Met Ala Asp Phe Glu Asp Ala Cys Ala Pro Ser Trp Glu 
        115                 120                 125             

Asn Val Val Gln Gly Gln Ile Asn Met Arg Asp Ala Val Arg Arg Thr 
    130                 135                 140                 

Ile Glu Tyr Thr Ser Pro Glu Gly Lys His Tyr Lys Leu Asn Asp Glu 
145                 150                 155                 160 

Val Ala Val Leu Ile Val Arg Pro Arg Gly Trp His Leu Pro Glu Lys 
                165                 170                 175     

His Ile Arg Val Asp Gly Arg Val Ala Thr Gly Ala Leu Val Asp Phe 
            180                 185                 190         

Gly Leu Tyr Phe Tyr His Asn Ala Lys Glu Leu Leu Ala Arg Gly Thr 
        195                 200                 205             

Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu Ser His Leu Glu Ala Arg 
    210                 215                 220                 

Leu Trp Asn Asp Val Phe Asn Tyr Ala Gln Asp Ala Leu Gly Ile Pro 
225                 230                 235                 240 

Arg Gly Thr Ile Lys Ala Thr Val Leu Ile Glu Thr Ile Leu Ala Thr 
                245                 250                 255     

Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu Arg Asp His Ala Ala Gly 
            260                 265                 270         

Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe Ser Tyr Ile Lys Lys Phe 
        275                 280                 285             

Arg Asn His Pro Glu Val Ile Leu Pro Asp Arg Ala Gln Val Thr Met 
    290                 295                 300                 

Thr Val Pro Phe Met Arg Ala Tyr Thr Leu Leu Thr Ile Arg Thr Cys 
305                 310                 315                 320 

His Arg Arg Lys Ala Phe Ala Met Gly Gly Met Ala Ala Gln Ile Pro 
                325                 330                 335     

Ile Lys Asn Asp Pro Lys Ala Asn Glu Glu Ala Leu Ala Lys Val Arg 
            340                 345                 350         

Ala Asp Lys Glu Arg Glu Ala Gln Asp Gly His Asp Gly Thr Trp Val 
        355                 360                 365             

Ala His Pro Gly Leu Val Pro Val Ala Met Glu Val Phe Asn Arg Leu 
    370                 375                 380                 

Met Pro Thr Pro Asn Gln Leu His Arg Leu Arg Glu Asp Val Gln Val 
385                 390                 395                 400 

Thr Ala Ala Asp Leu Val Ala Val Pro Gln Gly Thr Ile Thr Glu Gly 
                405                 410                 415     

Gly Leu Arg Thr Asn Val Ala Val Ala Leu Arg Tyr Ile Glu Ala Trp 
            420                 425                 430         

Leu Arg Gly Ser Gly Ala Val Pro Ile Phe Asn Leu Met Glu Asp Ala 
        435                 440                 445             

Ala Thr Ala Glu Ile Ser Arg Ala Gln Ile Trp Gln Trp Ile His His 
    450                 455                 460                 

Pro Lys Gly Val Leu Asp Asp Gly Arg Lys Val Thr Val Glu Leu Phe 
465                 470                 475                 480 

Arg Gln Ile Leu Glu Glu Glu Leu Arg Lys Leu Lys Asp Glu Ile Gly 
                485                 490                 495     

Glu Glu Ala Tyr Ala Gln Ser Lys Phe Pro Leu Ala Ala Glu Leu Leu 
            500                 505                 510         

Asp Asp Ile Ser Thr Lys Asp Asp Phe Val Asp Phe Leu Thr Leu Pro 
        515                 520                 525             

Gly Tyr Glu His Leu Ala 
    530                 

<210>   673
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   673
Met Ala Gly Ser Tyr Ala Cys Pro Gln Gly Val Gln Ile Thr Gly Glu 
                5                   10                  15      

Tyr Arg Pro Glu Phe Ala Glu Ile Leu Thr Thr Asp Ala Leu Gln Phe 
            20                  25                  30          

Ile Ala Asp Leu Glu Arg Arg Phe Gly Pro Arg Arg Asp Glu Leu Leu 
        35                  40                  45              

Arg Leu Arg Lys Glu Arg Asp Glu Arg Leu Leu Ala Gly Glu Trp Pro 
    50                  55                  60                  

Asp Phe Leu Pro Glu Thr Lys Glu Ile Arg Glu Ser Glu Trp Thr Val 
65                  70                  75                  80  

Gly Pro Ile Pro Ala Asp Leu Gln Asp Arg Arg Val Glu Ile Thr Gly 
                85                  90                  95      

Pro Ser Ser Asp Arg Lys Met Val Ile Asn Ala Leu Asn Ser Gly Ala 
            100                 105                 110         

Lys Cys Phe Met Ala Asp Phe Glu Asp Ala Cys Ala Pro Ser Trp Glu 
        115                 120                 125             

Asn Val Val Gln Gly Gln Ile Asn Met Arg Asp Ala Val Arg Arg Thr 
    130                 135                 140                 

Ile Glu Tyr Thr Ser Pro Glu Gly Lys His Tyr Lys Leu Asn Asp Glu 
145                 150                 155                 160 

Val Ala Val Leu Ile Val Arg Pro Arg Gly Trp His Leu Pro Glu Lys 
                165                 170                 175     

His Ile Arg Val Asp Gly Arg Val Ala Thr Gly Ala Leu Val Asp Phe 
            180                 185                 190         

Gly Leu Tyr Phe Tyr His Asn Ala Lys Glu Leu Leu Ala Arg Gly Thr 
        195                 200                 205             

Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu Ser His Leu Glu Ala Arg 
    210                 215                 220                 

Leu Trp Asn Asp Val Phe Asn Tyr Ala Gln Asp Ala Leu Gly Ile Pro 
225                 230                 235                 240 

Arg Gly Thr Ile Lys Ala Thr Val Leu Ile Glu Thr Ile Leu Ala Thr 
                245                 250                 255     

Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu Arg Asp His Ala Ala Gly 
            260                 265                 270         

Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe Ser Tyr Ile Lys Lys Phe 
        275                 280                 285             

Arg Asn His Pro Glu Val Ile Leu Pro Asp Arg Ala Gln Val Thr Met 
    290                 295                 300                 

Thr Val Pro Phe Met Arg Ala Tyr Thr Leu Leu Thr Ile Arg Thr Cys 
305                 310                 315                 320 

His Arg Arg Lys Ala Phe Ala Met Gly Gly Met Ala Ala Gln Ile Pro 
                325                 330                 335     

Ile Lys Asn Asp Pro Lys Ala Asn Glu Glu Ala Leu Ala Lys Val Arg 
            340                 345                 350         

Ala Asp Lys Glu Arg Glu Ala Gln Asp Gly His Asp Gly Thr Trp Val 
        355                 360                 365             

Ala His Pro Gly Leu Val Pro Val Ala Met Glu Val Phe Asn Arg Leu 
    370                 375                 380                 

Met Pro Thr Pro Asn Gln Leu His Arg Leu Arg Glu Asp Val Gln Val 
385                 390                 395                 400 

Thr Ala Ala Asp Leu Val Ala Val Pro Gln Gly Thr Ile Thr Glu Gly 
                405                 410                 415     

Gly Leu Arg Thr Asn Val Ala Val Ala Leu Arg Tyr Ile Glu Ala Trp 
            420                 425                 430         

Leu Arg Gly Ser Gly Ala Val Pro Ile Phe Asn Leu Met Glu Asp Ala 
        435                 440                 445             

Ala Thr Ala Glu Ile Ser Arg Ala Gln Ile Trp Gln Trp Ile His His 
    450                 455                 460                 

Pro Lys Gly Val Leu Asp Asp Gly Arg Lys Val Thr Val Glu Leu Phe 
465                 470                 475                 480 

Arg Gln Ile Leu Glu Glu Glu Leu Arg Lys Leu Lys Asp Glu Ile Gly 
                485                 490                 495     

Glu Glu Ala Tyr Ala Gln Ser Lys Phe Pro Leu Ala Ala Glu Leu Leu 
            500                 505                 510         

Asp Asp Ile Ser Thr Lys Asp Asp Phe Val Asp Phe Leu Thr Leu Pro 
        515                 520                 525             

Gly Tyr Glu His Leu Ala 
    530                 

<210>   674
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   674
Met Ala Gly Ser Tyr Ala Cys Pro Gln Gly Val Gln Ile Thr Gly Glu 
                5                   10                  15      

Tyr Arg Pro Glu Phe Ala Glu Ile Leu Thr Thr Asp Ala Leu Gln Phe 
            20                  25                  30          

Ile Ala Glu Leu Glu Arg Arg Phe Gly Pro Arg Arg Asp Glu Leu Leu 
        35                  40                  45              

Arg Leu Arg Lys Glu Arg Asp Glu Arg Leu Leu Ala Gly Glu Trp Pro 
    50                  55                  60                  

Asp Phe Leu Pro Glu Thr Arg Glu Ile Arg Glu Ser Glu Trp Thr Val 
65                  70                  75                  80  

Gly Pro Ile Pro Ala Asp Leu Gln Asp Arg Arg Val Glu Ile Thr Gly 
                85                  90                  95      

Pro Ser Ser Asp Arg Lys Met Val Ile Asn Ala Leu Asn Ser Gly Ala 
            100                 105                 110         

Lys Cys Phe Met Ala Asp Phe Glu Asp Ala Cys Ala Pro Ser Trp Glu 
        115                 120                 125             

Asn Val Val Gln Gly Gln Ile Asn Met Arg Asp Ala Val Arg Arg Thr 
    130                 135                 140                 

Ile Glu Tyr Thr Ser Pro Glu Gly Lys His Tyr Lys Leu Asn Asp Glu 
145                 150                 155                 160 

Val Ala Val Leu Ile Val Arg Pro Arg Gly Trp His Leu Pro Glu Lys 
                165                 170                 175     

His Ile Arg Val Asp Gly Arg Val Ala Thr Gly Ala Leu Val Asp Phe 
            180                 185                 190         

Gly Leu Tyr Phe Tyr His Asn Ala Lys Glu Leu Leu Ala Arg Gly Thr 
        195                 200                 205             

Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu Ser His Leu Glu Ala Arg 
    210                 215                 220                 

Leu Trp Asn Asp Val Phe Asn Tyr Ala Gln Asp Ala Leu Gly Ile Pro 
225                 230                 235                 240 

Arg Gly Thr Ile Lys Ala Thr Val Leu Ile Glu Thr Ile Leu Ala Thr 
                245                 250                 255     

Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu Arg Asp His Ala Ala Gly 
            260                 265                 270         

Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe Ser Tyr Ile Lys Lys Phe 
        275                 280                 285             

Arg Asn His Pro Glu Val Ile Leu Pro Asp Arg Ala Gln Val Thr Met 
    290                 295                 300                 

Thr Val Pro Phe Met Arg Ala Tyr Thr Leu Leu Thr Ile Arg Thr Cys 
305                 310                 315                 320 

His Arg Arg Lys Ala Phe Ala Met Gly Gly Met Ala Ala Gln Ile Pro 
                325                 330                 335     

Ile Lys Asn Asp Pro Lys Ala Asn Glu Glu Ala Leu Ala Lys Val Arg 
            340                 345                 350         

Ala Asp Lys Glu Arg Glu Ala Gln Asp Gly His Asp Gly Thr Trp Val 
        355                 360                 365             

Ala His Pro Gly Leu Val Pro Val Ala Met Glu Val Phe Asn Arg Leu 
    370                 375                 380                 

Met Pro Thr Pro Asn Gln Leu His Arg Leu Arg Glu Asp Val Gln Val 
385                 390                 395                 400 

Thr Ala Ala Asp Leu Val Ala Val Pro Gln Gly Thr Ile Thr Glu Gly 
                405                 410                 415     

Gly Leu Arg Thr Asn Val Ala Val Ala Leu Arg Tyr Ile Glu Ala Trp 
            420                 425                 430         

Leu Arg Gly Ser Gly Ala Val Pro Ile Phe Asn Leu Met Glu Asp Ala 
        435                 440                 445             

Ala Thr Ala Glu Ile Ser Arg Ala Gln Ile Trp Gln Trp Ile His His 
    450                 455                 460                 

Pro Lys Gly Val Leu Asp Asp Gly Arg Lys Val Thr Val Glu Leu Phe 
465                 470                 475                 480 

Arg Gln Ile Leu Glu Glu Glu Leu Arg Lys Leu Lys Asp Glu Ile Gly 
                485                 490                 495     

Glu Glu Ala Tyr Ala Gln Ser Lys Phe Pro Leu Ala Ala Glu Leu Leu 
            500                 505                 510         

Asp Asp Ile Ser Thr Lys Asp Asp Phe Val Asp Phe Leu Thr Leu Pro 
        515                 520                 525             

Gly Tyr Glu His Leu Ala 
    530                 

<210>   675
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   675
Met Ala Gly Ser Tyr Ala Cys Pro Gln Gly Val Gln Ile Thr Gly Glu 
                5                   10                  15      

Tyr Arg Pro Glu Phe Ala Glu Ile Leu Thr Thr Asp Ala Leu Gln Phe 
            20                  25                  30          

Ile Ala Glu Leu Glu Arg Arg Phe Gly Pro Arg Arg Asp Glu Leu Leu 
        35                  40                  45              

Arg Leu Arg Lys Glu Arg Asp Glu Arg Leu Ile Ala Gly Glu Trp Pro 
    50                  55                  60                  

Asp Phe Leu Pro Glu Thr Lys Glu Ile Arg Glu Ser Glu Trp Thr Val 
65                  70                  75                  80  

Gly Pro Ile Pro Ala Asp Leu Gln Asp Arg Arg Val Glu Ile Thr Gly 
                85                  90                  95      

Pro Ser Ser Asp Arg Lys Met Val Ile Asn Ala Leu Asn Ser Gly Ala 
            100                 105                 110         

Lys Cys Phe Met Ala Asp Phe Glu Asp Ala Cys Ala Pro Ser Trp Glu 
        115                 120                 125             

Asn Val Val Gln Gly Gln Ile Asn Met Arg Asp Ala Val Arg Arg Thr 
    130                 135                 140                 

Ile Glu Tyr Thr Ser Pro Glu Gly Lys His Tyr Lys Leu Asn Asp Glu 
145                 150                 155                 160 

Val Ala Val Leu Ile Val Arg Pro Arg Gly Trp His Leu Pro Glu Lys 
                165                 170                 175     

His Ile Arg Val Asp Gly Arg Val Ala Thr Gly Ala Leu Val Asp Phe 
            180                 185                 190         

Gly Leu Tyr Phe Tyr His Asn Ala Lys Glu Leu Leu Ala Arg Gly Thr 
        195                 200                 205             

Gly Pro Tyr Phe Tyr Leu Pro Lys Met Glu Ser His Leu Glu Ala Arg 
    210                 215                 220                 

Leu Trp Asn Asp Val Phe Asn Tyr Ala Gln Asp Ala Leu Gly Ile Pro 
225                 230                 235                 240 

Arg Gly Thr Ile Lys Ala Thr Val Leu Ile Glu Thr Ile Leu Ala Thr 
                245                 250                 255     

Phe Glu Met Asp Glu Ile Leu Tyr Glu Leu Arg Asp His Ala Ala Gly 
            260                 265                 270         

Leu Asn Cys Gly Arg Trp Asp Tyr Ile Phe Ser Tyr Ile Lys Lys Phe 
        275                 280                 285             

Arg Asn His Pro Glu Val Ile Leu Pro Asp Arg Ala Gln Val Thr Met 
    290                 295                 300                 

Thr Val Pro Phe Met Arg Ala Tyr Thr Leu Leu Thr Ile Arg Thr Cys 
305                 310                 315                 320 

His Arg Arg Lys Ala Phe Ala Met Gly Gly Met Ala Ala Gln Ile Pro 
                325                 330                 335     

Ile Lys Asn Asp Pro Lys Ala Asn Glu Glu Ala Leu Ala Lys Val Arg 
            340                 345                 350         

Ala Asp Lys Glu Arg Glu Ala Gln Asp Gly His Asp Gly Thr Trp Val 
        355                 360                 365             

Ala His Pro Gly Leu Val Pro Val Ala Met Glu Val Phe Asn Arg Leu 
    370                 375                 380                 

Met Pro Thr Pro Asn Gln Leu His Arg Leu Arg Glu Asp Val Gln Val 
385                 390                 395                 400 

Thr Ala Ala Asp Leu Val Ala Val Pro Gln Gly Thr Ile Thr Glu Gly 
                405                 410                 415     

Gly Leu Arg Thr Asn Val Ala Val Ala Leu Arg Tyr Ile Glu Ala Trp 
            420                 425                 430         

Leu Arg Gly Ser Gly Ala Val Pro Ile Phe Asn Leu Met Glu Asp Ala 
        435                 440                 445             

Ala Thr Ala Glu Ile Ser Arg Ala Gln Ile Trp Gln Trp Ile His His 
    450                 455                 460                 

Pro Lys Gly Val Leu Asp Asp Gly Arg Lys Val Thr Val Glu Leu Phe 
465                 470                 475                 480 

Arg Gln Ile Leu Glu Glu Glu Leu Arg Lys Leu Lys Asp Glu Ile Gly 
                485                 490                 495     

Glu Glu Ala Tyr Ala Gln Ser Lys Phe Pro Leu Ala Ala Glu Leu Leu 
            500                 505                 510         

Asp Asp Ile Ser Thr Lys Asp Asp Phe Val Asp Phe Leu Thr Leu Pro 
        515                 520                 525             

Gly Tyr Glu His Leu Ala 
    530                 

<210>   676
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   676
atggcgggat cgtacgcttg cccacagggc gtgcaaatca cgggcgaata caggcctgag       60

ttcgccgaaa tcctcacgac ggacgcgctt caattcatcg cggagcttga gcgccgcttc      120

ggtccgaggc gggacgaact gcttcgcctg cgcaaggagc gggacgagcg gttgctcgcg      180

ggcgaatggc cggacttctt gccggagacc aaggagattc gcgagagcga gtggacggtc      240

gggcccatcc ccgcggatct gcaggatcgg cgcgtggaaa tcacgggccc gagttcggac      300

cggaagatgg tcatcaacgc cttgaactcg ggcgccaagt gcttcatggc ggactttgag      360

gacgcctgcg caccgtcctg ggagaacgtc gtgcagggtc agatcaacat gcgggacgca      420

gttcgccgca ccatcgaata cacgagcccc gaggggaagc actacaagct gaatgacgaa      480

gttgcggtgc tcatcgtgcg cccgcgcggc tggcacctgc ccgagaagca catccgggtg      540

gacggccggg tggccacggg cgcgctcgtc gacttcgggc tttacttcta ccacaatgcc      600

aaggagcttt tggcgcgcgg caccgggccc tacttctacc tgccgaagat ggagagccac      660

ctcgaggcga ggctgtggaa cgacgtgttc aactacgccc aggacgcgct cggcatcccg      720

cgcggcacca tcaaggccac tgtgctcatc gagaccatcc tcgcgacgtt cgagatggac      780

gagatcctgt atgagctgcg cgatcacgcc gcggggctca actgcggccg ctgggactac      840

atcttcagct acatcaagaa gttccgcaat cacccggagg tcatcctgcc tgaccgggcg      900

caggtgacga tgacggtgcc gttcatgcgc gcgtacaccc tgctcaccat ccgcacgtgc      960

catcggcgca aggcgttcgc gatgggcggc atggcggcgc agatccccat caagaacgac     1020

ccgaaggcga acgaggaggc gctcgccaag gtgcgcgcgg acaaggagcg cgaggcgcag     1080

gacggccacg acggcacctg ggtggcgcac ccgggtctcg tgcccgtggc gatggaggtg     1140

ttcaatcgcc tcatgcccac gcccaaccag ttgcaccgcc tgcgcgagga cgtccaggtc     1200

accgcggccg atctcgtcgc ggtcccgcag ggcaccatca ccgaaggcgg cctgcgcacc     1260

aacgtcgccg tggcgcttcg ctacatcgag gcttggctgc gcggttccgg cgcggtgccc     1320

atcttcaacc tgatggaaga cgcggcgacg gcggagatct cccgcgcgca gatctggcag     1380

tggatccatc acccgaaagg cgtcctcgac gacggccgca aggtgacggt ggagctgttc     1440

cggcagattc tcgaagagga gttgcgcaag ttgaaggacg agatcggcga ggaggcgtac     1500

gcacagagca agttcccgct cgcggccgaa cttctcgacg aaatctcgac gaaggacgac     1560

ttcgtcgact tcctgacgct gccgggttac gagcacctgg cgtga                     1605


<210>   677
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   677
atggcgggat cgtacgcttg cccacagggc gtgcaaatca cgggcgatta caggcctgag       60

ttcgccgaaa tcctcacgac ggacgcgctt caattcatcg cggagcttga gcgccgcttc      120

ggtccgaggc gggacgaact gcttcgcctg cgcaaggagc gggacgagcg gttgctcgcg      180

ggcgaatggc cggacttctt gccggagacc aaggagattc gcgagagcga gtggacggtc      240

gggcccatcc ccgcggatct gcaggatcgg cgcgtggaaa tcacgggccc gagttcggac      300

cggaagatgg tcatcaacgc cttgaactcg ggcgccaagt gcttcatggc ggactttgag      360

gacgcctgcg caccgtcctg ggagaacgtc gtgcagggtc agatcaacat gcgggacgca      420

gttcgccgca ccatcgaata cacgagcccc gaggggaagc actacaagct gaatgacgaa      480

gttgcggtgc tcatcgtgcg cccgcgcggc tggcacctgc ccgagaagca catccgggtg      540

gacggccggg tggccacggg cgcgctcgtc gacttcgggc tttacttcta ccacaatgcc      600

aaggagcttt tggcgcgcgg caccgggccc tacttctacc tgccgaagat ggagagccac      660

ctcgaggcga ggctgtggaa cgacgtgttc aactacgccc aggacgcgct cggcatcccg      720

cgcggcacca tcaaggccac tgtgctcatc gagaccatcc tcgcgacgtt cgagatggac      780

gagatcctgt atgagctgcg cgatcacgcc gcggggctca actgcggccg ctgggactac      840

atcttcagct acatcaagaa gttccgcaat cacccggagg tcatcctgcc tgaccgggcg      900

caggtgacga tgacggtgcc gttcatgcgc gcgtacaccc tgctcaccat ccgcacgtgc      960

catcggcgca aggcgttcgc gatgggcggc atggcggcgc agatccccat caagaacgac     1020

ccgaaggcga acgaggaggc gctcgccaag gtgcgcgcgg acaaggagcg cgaggcgcag     1080

gacggccacg acggcacctg ggtggcgcac ccgggtctcg tgcccgtggc gatggaggtg     1140

ttcaatcgcc tcatgcccac gcccaaccag ttgcaccgcc tgcgcgagga cgtccaggtc     1200

accgcggccg atctcgtcgc ggtcccgcag ggcaccatca ccgaaggcgg cctgcgcacc     1260

aacgtcgccg tggcgcttcg ctacatcgag gcttggctgc gcggttccgg cgcggtgccc     1320

atcttcaacc tgatggaaga cgcggcgacg gcggagatct cccgcgcgca gatctggcag     1380

tggatccatc acccgaaagg cgtcctcgac gacggccgca aggtgacggt ggagctgttc     1440

cggcagattc tcgaagagga gttgcgcaag ttgaaggacg agatcggcga ggaggcgtac     1500

gcacagagca agttcccgct cgcggccgaa cttctcgacg acatctcgac gaaggacgac     1560

ttcgtcgact tcctgacgct gccgggttac gagcacctgg cgtga                     1605


<210>   678
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   678
atggcgggat cgtacgcttg cccacagggc gtgcaaatca cgggcgaata caggcctgag       60

ttcgccgaaa tcctcacgac ggacgcgctt caattcatcg cggatcttga gcgccgcttc      120

ggtccgaggc gggacgaact gcttcgcctg cgcaaggagc gggacgagcg gttgctcgcg      180

ggcgaatggc cggacttctt gccggagacc aaggagattc gcgagagcga gtggacggtc      240

gggcccatcc ccgcggatct gcaggatcgg cgcgtggaaa tcacgggccc gagttcggac      300

cggaagatgg tcatcaacgc cttgaactcg ggcgccaagt gcttcatggc ggactttgag      360

gacgcctgcg caccgtcctg ggagaacgtc gtgcagggtc agatcaacat gcgggacgca      420

gttcgccgca ccatcgaata cacgagcccc gaggggaagc actacaagct gaatgacgaa      480

gttgcggtgc tcatcgtgcg cccgcgcggc tggcacctgc ccgagaagca catccgggtg      540

gacggccggg tggccacggg cgcgctcgtc gacttcgggc tttacttcta ccacaatgcc      600

aaggagcttt tggcgcgcgg caccgggccc tacttctacc tgccgaagat ggagagccac      660

ctcgaggcga ggctgtggaa cgacgtgttc aactacgccc aggacgcgct cggcatcccg      720

cgcggcacca tcaaggccac tgtgctcatc gagaccatcc tcgcgacgtt cgagatggac      780

gagatcctgt atgagctgcg cgatcacgcc gcggggctca actgcggccg ctgggactac      840

atcttcagct acatcaagaa gttccgcaat cacccggagg tcatcctgcc tgaccgggcg      900

caggtgacga tgacggtgcc gttcatgcgc gcgtacaccc tgctcaccat ccgcacgtgc      960

catcggcgca aggcgttcgc gatgggcggc atggcggcgc agatccccat caagaacgac     1020

ccgaaggcga acgaggaggc gctcgccaag gtgcgcgcgg acaaggagcg cgaggcgcag     1080

gacggccacg acggcacctg ggtggcgcac ccgggtctcg tgcccgtggc gatggaggtg     1140

ttcaatcgcc tcatgcccac gcccaaccag ttgcaccgcc tgcgcgagga cgtccaggtc     1200

accgcggccg atctcgtcgc ggtcccgcag ggcaccatca ccgaaggcgg cctgcgcacc     1260

aacgtcgccg tggcgcttcg ctacatcgag gcttggctgc gcggttccgg cgcggtgccc     1320

atcttcaacc tgatggaaga cgcggcgacg gcggagatct cccgcgcgca gatctggcag     1380

tggatccatc acccgaaagg cgtcctcgac gacggccgca aggtgacggt ggagctgttc     1440

cggcagattc tcgaagagga gttgcgcaag ttgaaggacg agatcggcga ggaggcgtac     1500

gcacagagca agttcccgct cgcggccgaa cttctcgacg acatctcgac gaaggacgac     1560

ttcgtcgact tcctgacgct gccgggttac gagcacctgg cgtga                     1605


<210>   679
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   679
atggcgggat cgtacgcttg cccacagggc gtgcaaatca cgggcgaata caggcctgag       60

ttcgccgaaa tcctcacgac ggacgcgctt caattcatcg cggagcttga gcgccgcttc      120

ggtccgaggc gggacgaact gcttcgcctg cgcaaggagc gggacgagcg gttgctcgcg      180

ggcgaatggc cggacttctt gccggagacc cgtgagattc gcgagagcga gtggacggtc      240

gggcccatcc ccgcggatct gcaggatcgg cgcgtggaaa tcacgggccc gagttcggac      300

cggaagatgg tcatcaacgc cttgaactcg ggcgccaagt gcttcatggc ggactttgag      360

gacgcctgcg caccgtcctg ggagaacgtc gtgcagggtc agatcaacat gcgggacgca      420

gttcgccgca ccatcgaata cacgagcccc gaggggaagc actacaagct gaatgacgaa      480

gttgcggtgc tcatcgtgcg cccgcgcggc tggcacctgc ccgagaagca catccgggtg      540

gacggccggg tggccacggg cgcgctcgtc gacttcgggc tttacttcta ccacaatgcc      600

aaggagcttt tggcgcgcgg caccgggccc tacttctacc tgccgaagat ggagagccac      660

ctcgaggcga ggctgtggaa cgacgtgttc aactacgccc aggacgcgct cggcatcccg      720

cgcggcacca tcaaggccac tgtgctcatc gagaccatcc tcgcgacgtt cgagatggac      780

gagatcctgt atgagctgcg cgatcacgcc gcggggctca actgcggccg ctgggactac      840

atcttcagct acatcaagaa gttccgcaat cacccggagg tcatcctgcc tgaccgggcg      900

caggtgacga tgacggtgcc gttcatgcgc gcgtacaccc tgctcaccat ccgcacgtgc      960

catcggcgca aggcgttcgc gatgggcggc atggcggcgc agatccccat caagaacgac     1020

ccgaaggcga acgaggaggc gctcgccaag gtgcgcgcgg acaaggagcg cgaggcgcag     1080

gacggccacg acggcacctg ggtggcgcac ccgggtctcg tgcccgtggc gatggaggtg     1140

ttcaatcgcc tcatgcccac gcccaaccag ttgcaccgcc tgcgcgagga cgtccaggtc     1200

accgcggccg atctcgtcgc ggtcccgcag ggcaccatca ccgaaggcgg cctgcgcacc     1260

aacgtcgccg tggcgcttcg ctacatcgag gcttggctgc gcggttccgg cgcggtgccc     1320

atcttcaacc tgatggaaga cgcggcgacg gcggagatct cccgcgcgca gatctggcag     1380

tggatccatc acccgaaagg cgtcctcgac gacggccgca aggtgacggt ggagctgttc     1440

cggcagattc tcgaagagga gttgcgcaag ttgaaggacg agatcggcga ggaggcgtac     1500

gcacagagca agttcccgct cgcggccgaa cttctcgacg acatctcgac gaaggacgac     1560

ttcgtcgact tcctgacgct gccgggttac gagcacctgg cgtga                     1605


<210>   680
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   680
atggcgggat cgtacgcttg cccacagggc gtgcaaatca cgggcgaata caggcctgag       60

ttcgccgaaa tcctcacgac ggacgcgctt caattcatcg cggagcttga gcgccgcttc      120

ggtccgaggc gggacgaact gcttcgcctg cgcaaggagc gggacgagcg gttgattgcg      180

ggcgaatggc cggacttctt gccggagacc aaggagattc gcgagagcga gtggacggtc      240

gggcccatcc ccgcggatct gcaggatcgg cgcgtggaaa tcacgggccc gagttcggac      300

cggaagatgg tcatcaacgc cttgaactcg ggcgccaagt gcttcatggc ggactttgag      360

gacgcctgcg caccgtcctg ggagaacgtc gtgcagggtc agatcaacat gcgggacgca      420

gttcgccgca ccatcgaata cacgagcccc gaggggaagc actacaagct gaatgacgaa      480

gttgcggtgc tcatcgtgcg cccgcgcggc tggcacctgc ccgagaagca catccgggtg      540

gacggccggg tggccacggg cgcgctcgtc gacttcgggc tttacttcta ccacaatgcc      600

aaggagcttt tggcgcgcgg caccgggccc tacttctacc tgccgaagat ggagagccac      660

ctcgaggcga ggctgtggaa cgacgtgttc aactacgccc aggacgcgct cggcatcccg      720

cgcggcacca tcaaggccac tgtgctcatc gagaccatcc tcgcgacgtt cgagatggac      780

gagatcctgt atgagctgcg cgatcacgcc gcggggctca actgcggccg ctgggactac      840

atcttcagct acatcaagaa gttccgcaat cacccggagg tcatcctgcc tgaccgggcg      900

caggtgacga tgacggtgcc gttcatgcgc gcgtacaccc tgctcaccat ccgcacgtgc      960

catcggcgca aggcgttcgc gatgggcggc atggcggcgc agatccccat caagaacgac     1020

ccgaaggcga acgaggaggc gctcgccaag gtgcgcgcgg acaaggagcg cgaggcgcag     1080

gacggccacg acggcacctg ggtggcgcac ccgggtctcg tgcccgtggc gatggaggtg     1140

ttcaatcgcc tcatgcccac gcccaaccag ttgcaccgcc tgcgcgagga cgtccaggtc     1200

accgcggccg atctcgtcgc ggtcccgcag ggcaccatca ccgaaggcgg cctgcgcacc     1260

aacgtcgccg tggcgcttcg ctacatcgag gcttggctgc gcggttccgg cgcggtgccc     1320

atcttcaacc tgatggaaga cgcggcgacg gcggagatct cccgcgcgca gatctggcag     1380

tggatccatc acccgaaagg cgtcctcgac gacggccgca aggtgacggt ggagctgttc     1440

cggcagattc tcgaagagga gttgcgcaag ttgaaggacg agatcggcga ggaggcgtac     1500

gcacagagca agttcccgct cgcggccgaa cttctcgacg acatctcgac gaaggacgac     1560

ttcgtcgact tcctgacgct gccgggttac gagcacctgg cgtga                     1605


<210>   681
<211>   489
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   681
Met Tyr Pro Phe Ser Ser Tyr Met Thr Phe Thr Arg Arg Val Ser Pro 
                5                   10                  15      

Trp Asp Arg Arg His Ala Arg Arg Arg Ala Thr Glu Met Glu Ala Arg 
            20                  25                  30          

Met Met Thr Ile Pro Trp Glu Thr Leu Lys Glu Glu Leu Gly Asp Lys 
        35                  40                  45              

Leu Ser Phe Gly Glu Ser Val Arg Arg Ser His Ala Lys Asp Glu Ser 
    50                  55                  60                  

Tyr His Pro Glu His Leu Pro Asp Ala Val Ala Tyr Pro Glu Glu Thr 
65                  70                  75                  80  

Ala Asp Val Val Ala Leu Ala Arg Phe Ser His Ala His Gly Val Pro 
                85                  90                  95      

Leu Val Ala Tyr Gly Ala Gly Ser Gly Leu Glu Gly Gln Val Ile Pro 
            100                 105                 110         

Val Arg Gly Gly Ile Ser Val Asp Phe Ser Arg Met Asn Arg Val Leu 
        115                 120                 125             

Glu Ile Arg Pro Asp Asp Phe Leu Val Cys Val Glu Pro Gly Val Thr 
    130                 135                 140                 

Arg Gln Gln Leu Asn Asp Ala Leu Arg Pro Tyr Gly Leu Met Phe Pro 
145                 150                 155                 160 

Val Asp Pro Gly Ala Asn Ala Ser Leu Gly Gly Met Ala Ala Thr Asn 
                165                 170                 175     

Ala Ser Gly Thr Thr Ala Val Arg Tyr Gly Pro Met Lys Ala Asn Val 
            180                 185                 190         

Arg Lys Leu Glu Val Val Leu Ala Asp Gly Arg Val Ile Glu Val Gly 
        195                 200                 205             

Thr Leu Ala Ala Lys Ser Ser Ser Gly Tyr Asn Leu Val Glu Leu Phe 
    210                 215                 220                 

Val Gly Ser Glu Gly Thr Leu Gly Leu Phe Thr Lys Leu Trp Leu Arg 
225                 230                 235                 240 

Val Tyr Gly Val Pro Glu Ala Thr Leu Ala Ala Ser Ala Glu Phe Ala 
                245                 250                 255     

Thr Val Arg Glu Ala Val Asp Ala Val Cys Met Leu Ile Gly Ser Gly 
            260                 265                 270         

Leu Gln Leu Thr Arg Cys Glu Leu Val Thr Lys Pro Tyr Ile Glu Ile 
        275                 280                 285             

Ile Asn Arg Gln Phe Asp Thr Ser Tyr Thr Pro Ala Pro Thr Leu Phe 
    290                 295                 300                 

Leu Glu Leu Ser Gly Ser Gln Ala Ala Val Gln Ala Asp Met Gly Thr 
305                 310                 315                 320 

Val Asp Glu Ile Leu Arg Asp Ala Gly Ala Ala Arg Val Ser Val Val 
                325                 330                 335     

Met Asp Glu Arg Glu Arg Gln Lys Leu Trp His Ala Arg His Asn Ala 
            340                 345                 350         

Ala Tyr Ala Leu Met Arg Thr Tyr Pro Gly Leu Ser His Leu Ser Thr 
        355                 360                 365             

Asp Val Cys Val Pro Met Ser Lys Leu Pro Glu Ala Val Asp Val Ala 
    370                 375                 380                 

Glu Thr Trp Ile Glu Arg Leu Gly Ile Arg Gly Gly Ile Val Gly His 
385                 390                 395                 400 

Val Gly Asp Gly Asn Phe His Val Ser Leu Met Val Asn Pro Ser Asp 
                405                 410                 415     

Pro Asp Asp Leu Gly Arg Ala Tyr Glu Leu Ser His His Leu Val Glu 
            420                 425                 430         

Tyr Ala Leu Ser Val Gly Gly Thr Cys Thr Gly Glu His Gly Val Gly 
        435                 440                 445             

Leu Gly Lys Met Lys Tyr Gln Lys Gln Glu His Gly Glu Ala Leu Ala 
    450                 455                 460                 

Leu Met Gln Ala Val Lys Arg Leu Phe Asp Pro Ala Asp Met Leu Asn 
465                 470                 475                 480 

Pro Gly Lys Leu Val Asp Gly Ile Ala 
                485                 

<210>   682
<211>   1470
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   682
atgtatccct tttcatccta tatgaccttt acgcggcgcg taagcccctg ggacaggcgc       60

catgcgcgca ggcgtgcgac agaaatggag gcccggatga tgaccatccc ttgggagacg      120

ttgaaagagg agctcggcga caagctcagc ttcggcgaga gcgttcgccg atcgcacgcg      180

aaggacgaat cgtatcaccc ggagcacctg ccggacgccg tggcctatcc ggaggagacg      240

gcggatgtcg tggcacttgc gcggttttcg catgcgcacg gggtgccgct cgtcgcttac      300

ggcgccggat cgggcctcga gggccaggtc atccccgtgc gcggcggcat ctcggtcgac      360

ttttcgcgga tgaaccgcgt gctcgagatc cggccggacg acttcctcgt ctgcgtcgag      420

cccggcgtca cgcgccagca gttgaacgac gccctgcgcc cgtacggcct catgtttccg      480

gtcgatcccg gcgccaacgc gtccttgggc ggcatggcgg cgacgaacgc gagcggcacg      540

acggcggtgc ggtatggccc gatgaaggcg aacgtgcgga agctcgaggt ggtgctcgcg      600

gatgggcgcg tgatcgaggt gggaacgctc gccgccaaat ccagctccgg ctataatctc      660

gtcgaactct tcgtgggctc ggaaggcacg ctaggcttgt tcacgaagct ctggctccgc      720

gtctacggtg tgcccgaggc gacgctcgcc gcctccgcgg agtttgcgac ggtccgcgag      780

gcggtggacg ccgtgtgcat gctcatcggc agcgggctcc agctcacgcg ttgcgaactt      840

gtgacaaagc cgtacatcga gatcatcaac cgccagtttg acacgtccta cacgcccgcg      900

ccgaccctgt tcctcgagct gtcgggctct caggccgcgg tgcaggccga catggggacg      960

gtcgacgaga tcctgcgcga cgccggcgca gcccgcgtct ccgtcgtcat ggatgagcgc     1020

gaacgccaga agctttggca cgcgcggcac aacgcggcgt atgcgctcat gcggacctac     1080

ccagggctgt cgcacctctc gacggacgtg tgcgtgccca tgtcgaagct gcccgaggca     1140

gtcgacgtgg cggagacgtg gatcgagcgg ctcgggatcc gcgggggcat cgtggggcac     1200

gtcggcgacg gcaacttcca cgtcagcctg atggtcaacc cgagcgaccc ggacgatctc     1260

ggccgcgcct acgagctctc gcaccacctg gtcgagtacg cgctgtccgt cggcggcacg     1320

tgcacgggcg agcacggcgt cgggctcggc aagatgaagt atcagaagca ggagcacggc     1380

gaggcgctcg ccctgatgca ggcggtgaag cggctgttcg atccggccga catgctcaac     1440

cccgggaagc tggtcgacgg gatcgcgtga                                      1470


<210>   683
<211>   440
<212>   PRT
<213>   Bacillus sp. B14905

<400>   683
Leu Glu Glu Gln Val Ser Thr Asn Glu Thr Val Arg Gln Leu His Gly 
                5                   10                  15      

Lys Asp Glu Ser His His Pro Met Ser Leu Pro Asp Ile Val Val Phe 
            20                  25                  30          

Pro Arg Ser Thr Ala Asp Val Ser Ala Ile Leu Lys Val Ala His Ala 
        35                  40                  45              

Gln Arg Val Pro Val Val Pro Phe Gly Val Gly Ser Ser Leu Glu Gly 
    50                  55                  60                  

Asn Ala Ile Pro Ile Ala Asn Gly Ile Ser Ile Asp Phe Ser Glu Met 
65                  70                  75                  80  

Asn Ala Ile Leu Glu Val Arg Pro Glu Asp Leu Leu Val Lys Val Gln 
                85                  90                  95      

Pro Gly Val Thr Arg Ser Gln Leu Asn Lys Glu Leu Lys Lys His Gly 
            100                 105                 110         

Leu Gln Phe Thr Val Asp Pro Gly Ala Asp Ala Thr Leu Gly Gly Met 
        115                 120                 125             

Ala Ala Thr Asn Ala Ser Gly Thr Thr Ala Val Arg Tyr Gly Val Met 
    130                 135                 140                 

Arg Asp Gln Val Arg Asp Leu Glu Val Val Leu Ala Asp Gly Ser Val 
145                 150                 155                 160 

Ile His Thr Gly Asn Leu Ala Ala Lys Ser Ser Ser Gly Tyr His Leu 
                165                 170                 175     

Asn Gly Leu Phe Val Gly Ser Glu Gly Thr Leu Gly Cys Phe Thr Glu 
            180                 185                 190         

Leu Thr Leu Lys Val Tyr Gly Ile Pro Glu Phe Val Thr Ala Gly Arg 
        195                 200                 205             

Ala Val Phe Asn Thr Val Gly Asp Ala Val Ser Ser Val Thr Ala Leu 
    210                 215                 220                 

Leu Gln Thr Gly Ile Ser Val Gly Arg Val Glu Leu Val Asp Glu Ala 
225                 230                 235                 240 

Ser Ile Gln Gln Ala Asn Ile Tyr Asn Asp Thr Ala Phe Ser Glu Lys 
                245                 250                 255     

Pro Thr Leu Phe Leu Glu Phe His Gly Asn Glu Ala Gly Met His Ala 
            260                 265                 270         

Asp Ile Ala Phe Ala Thr Glu Ile Phe Glu Asp Phe His Cys Leu Ser 
        275                 280                 285             

Val Glu Phe Glu His Asp Asn Ala Gly Arg Asn Lys Leu Trp Glu Ala 
    290                 295                 300                 

Arg His Ser Leu Ala Tyr Ala Tyr Met His Ala His Pro Gly Lys Lys 
305                 310                 315                 320 

Leu Met Ser Thr Asp Val Cys Val Pro Ile Ser Met Leu Ala Glu Thr 
                325                 330                 335     

Ile Leu Tyr Ala Arg Glu Gln Leu Asn Thr Val Gly Leu Ala Gly Gly 
            340                 345                 350         

Ile Val Gly His Val Gly Asp Gly Asn Phe His Ala Leu Leu Met Leu 
        355                 360                 365             

Asn Pro Asp Asp Ala Glu Glu Gln Ala Lys Ala Asp Arg Phe Asn Glu 
    370                 375                 380                 

His Ile Val Gln Tyr Ala Leu Leu Arg Gly Gly Thr Cys Thr Gly Glu 
385                 390                 395                 400 

His Gly Val Gly Ile Gly Lys Met Arg Tyr Gln Ala Thr Glu His Gly 
                405                 410                 415     

Ser Ser Leu Ala Val Met Lys Ser Ile Lys Ile Ala Leu Asp Pro Leu 
            420                 425                 430         

Asn Ile Met Asn Pro Gly Lys Ile 
        435                 440 

<210>   684
<211>   439
<212>   PRT
<213>   Bacillus cereus G9241

<400>   684
Gly Asp Arg Val Val Val Asn Thr Thr Val Arg Glu Leu His Ser Lys 
                5                   10                  15      

Asp Glu Ser Tyr His Ala Ser Ser Leu Pro Asp Val Val Val Phe Pro 
            20                  25                  30          

Lys Thr Thr Glu Glu Val Ser Ser Ile Met Lys Val Ala Ser Gln His 
        35                  40                  45              

Gly Thr Ala Ile Val Pro Phe Gly Val Gly Ser Ser Leu Glu Gly His 
    50                  55                  60                  

Val Ile Pro Tyr Glu Lys Gly Ile Thr Val Asp Phe Ser Leu Met Asn 
65                  70                  75                  80  

Lys Ile Leu Glu Ile Arg Glu Lys Asp Phe Leu Val Arg Val Gln Pro 
                85                  90                  95      

Gly Val Thr Arg Ser Gln Leu Asn Lys Glu Leu Lys Lys Tyr Gly Leu 
            100                 105                 110         

Phe Phe Ser Val Asp Pro Gly Ala Asp Ala Thr Leu Gly Gly Met Ala 
        115                 120                 125             

Ala Thr Asn Ala Ser Gly Thr Thr Ala Val Lys Tyr Gly Val Met Arg 
    130                 135                 140                 

Asp Gln Val Arg Asp Leu Glu Val Val Leu Ala Asp Gly Glu Val Ile 
145                 150                 155                 160 

His Thr Gly Asn Leu Ala Ala Lys Ser Ser Ser Gly Tyr His Leu Asn 
                165                 170                 175     

Gly Ile Phe Val Gly Ser Glu Gly Thr Leu Gly Cys Phe Thr Glu Leu 
            180                 185                 190         

Thr Leu Lys Val Tyr Gly Ile Pro Glu His Val Met Ala Ala Arg Ala 
        195                 200                 205             

Ser Phe Pro Ala Ile Asn Asp Ala Val Glu Ala Val Ile Asn Ile Leu 
    210                 215                 220                 

Gln Ala Gly Ile Pro Ile Ala Arg Ile Glu Leu Val Asp Glu Leu Ser 
225                 230                 235                 240 

Met Lys Gln Val Asn His Tyr Ser Glu Thr Ser Tyr Arg Glu Glu Pro 
                245                 250                 255     

Thr Leu Phe Leu Glu Phe His Gly Asn Glu Ala Gly Leu Lys Gln Asp 
            260                 265                 270         

Ile Glu Phe Thr Lys Glu Ile Val Phe Asp His Lys Cys Lys Glu Val 
        275                 280                 285             

Ala Phe Glu Thr Glu Thr Ala Ala Arg Asn Lys Leu Trp Asp Ala Arg 
    290                 295                 300                 

His Asn Leu Ala Tyr Ala Tyr Val His Ser Tyr Pro Gly Lys Lys Leu 
305                 310                 315                 320 

Met Ser Thr Asp Val Cys Val Pro Ile Ser Glu Leu Ala Gly Ala Ile 
                325                 330                 335     

Gln His Ala Lys Glu Thr Leu Asp Lys Val Gly Leu Val Gly Gly Ile 
            340                 345                 350         

Leu Gly His Val Gly Asp Gly Asn Phe His Val Leu Leu Met Val Asp 
        355                 360                 365             

Pro Asn Asp Lys Glu Glu Val Glu Lys Ala Asp Glu Ile Asn Glu Ser 
    370                 375                 380                 

Ile Val Leu Tyr Ala Leu Lys Arg Gly Gly Thr Cys Thr Gly Glu His 
385                 390                 395                 400 

Gly Val Gly Ile Gly Lys Arg Lys Tyr Gln Glu Glu Glu His Gly Ala 
                405                 410                 415     

Ala Leu Phe Val Met Glu Lys Ile Lys Arg Ala Leu Asp Pro Gln Asn 
            420                 425                 430         

Ile Leu Asn Pro Asn Lys Val 
        435                 

<210>   685
<211>   438
<212>   PRT
<213>   Bacillus thuringiensis str. Al Hakam

<400>   685
Asp Arg Val Val Ile Asn Thr Thr Val Arg Glu Leu His Ser Lys Asp 
                5                   10                  15      

Glu Ser Tyr His Ala Ser Ser Leu Pro Asp Val Val Val Phe Pro Lys 
            20                  25                  30          

Thr Thr Glu Glu Val Ser Thr Ile Met Lys Ile Ala Ser Glu His Gly 
        35                  40                  45              

Thr Pro Val Val Pro Phe Gly Val Gly Ser Ser Leu Glu Gly His Val 
    50                  55                  60                  

Ile Pro Tyr Glu Lys Gly Ile Thr Val Asp Phe Ser Leu Met Asn Lys 
65                  70                  75                  80  

Ile Leu Glu Ile Arg Glu Lys Asp Phe Leu Val Lys Val Gln Pro Gly 
                85                  90                  95      

Val Thr Arg Ser Gln Leu Asn Lys Glu Leu Lys Lys Tyr Gly Leu Phe 
            100                 105                 110         

Phe Ser Val Asp Pro Gly Ala Asp Ala Thr Leu Gly Gly Met Ala Ala 
        115                 120                 125             

Thr Asn Ala Ser Gly Thr Thr Ala Val Lys Tyr Gly Val Met Arg Asp 
    130                 135                 140                 

Gln Val Arg Asp Leu Glu Val Val Leu Ala Asp Gly Glu Val Ile His 
145                 150                 155                 160 

Thr Gly Asn Leu Ala Ala Lys Ser Ser Ser Gly Tyr His Leu Asn Gly 
                165                 170                 175     

Val Phe Val Gly Ser Glu Gly Thr Leu Gly Cys Phe Thr Glu Leu Thr 
            180                 185                 190         

Leu Lys Val Tyr Gly Ile Pro Glu His Val Met Ala Ala Arg Ala Ser 
        195                 200                 205             

Phe Pro Ala Ile Asn Asp Ala Val Glu Ala Val Ile Asn Ile Leu Gln 
    210                 215                 220                 

Ala Gly Ile Pro Ile Ala Arg Ile Glu Leu Val Asp Glu Leu Ser Met 
225                 230                 235                 240 

Lys Gln Val Asn His Tyr Ser Glu Thr Ser Tyr Arg Glu Glu Pro Thr 
                245                 250                 255     

Leu Phe Leu Glu Phe His Gly Asn Glu Ala Gly Leu Lys Gln Asp Val 
            260                 265                 270         

Glu Phe Thr Lys Glu Ile Val Phe Asp Gln Lys Cys Lys Glu Val Ala 
        275                 280                 285             

Phe Glu Thr Glu Thr Ala Ala Arg Asn Lys Leu Trp Asp Ala Arg His 
    290                 295                 300                 

Asn Leu Ala Tyr Ala Tyr Val His Ser Tyr Pro Gly Lys Lys Leu Met 
305                 310                 315                 320 

Ser Thr Asp Val Cys Val Pro Ile Ser Glu Leu Ala Gly Ala Ile Gln 
                325                 330                 335     

Gln Ala Lys Glu Thr Leu Glu Lys Asn Gly Leu Val Gly Gly Ile Leu 
            340                 345                 350         

Gly His Val Gly Asp Gly Asn Phe His Val Leu Leu Met Val Asp Pro 
        355                 360                 365             

Asn Asp Lys Glu Glu Val Glu Lys Ala Asp Glu Ile Asn Glu Ser Ile 
    370                 375                 380                 

Val Leu Tyr Ala Leu Lys Arg Gly Gly Thr Cys Thr Gly Glu His Gly 
385                 390                 395                 400 

Val Gly Ile Gly Lys Arg Lys Tyr Gln Glu Glu Glu His Gly Ala Ala 
                405                 410                 415     

Leu Phe Val Met Glu Lys Ile Lys Lys Ala Leu Asp Pro Gln Asn Ile 
            420                 425                 430         

Leu Asn Pro Asn Lys Val 
        435             

<210>   686
<211>   438
<212>   PRT
<213>   Bacillus thuringiensis serovar konkukian str. 97-27

<400>   686
Asp Arg Val Val Ile Asn Thr Thr Val Arg Glu Leu His Ser Lys Asp 
                5                   10                  15      

Glu Ser Tyr His Ala Ser Ser Leu Pro Asp Val Val Val Phe Pro Lys 
            20                  25                  30          

Thr Thr Glu Glu Val Ser Thr Ile Met Lys Val Ala Ser Glu His Gly 
        35                  40                  45              

Thr Pro Val Val Pro Phe Gly Val Gly Ser Ser Leu Glu Gly His Val 
    50                  55                  60                  

Ile Pro Tyr Glu Lys Gly Ile Thr Val Asp Phe Ser Leu Met Asn Lys 
65                  70                  75                  80  

Ile Leu Glu Ile Arg Glu Lys Asp Phe Leu Val Arg Val Gln Pro Gly 
                85                  90                  95      

Val Thr Arg Ser Gln Leu Asn Lys Glu Leu Lys Lys Tyr Gly Leu Phe 
            100                 105                 110         

Phe Ser Val Asp Pro Gly Ala Asp Ala Thr Leu Gly Gly Met Ala Ala 
        115                 120                 125             

Thr Asn Ala Ser Gly Thr Thr Ala Val Lys Tyr Gly Val Met Arg Asp 
    130                 135                 140                 

Gln Val Arg Asp Leu Glu Val Val Leu Ala Asp Gly Glu Val Ile His 
145                 150                 155                 160 

Thr Gly Asn Leu Ala Ala Lys Ser Ser Ser Gly Tyr His Leu Asn Gly 
                165                 170                 175     

Val Phe Val Gly Ser Glu Gly Thr Leu Gly Cys Phe Thr Glu Leu Thr 
            180                 185                 190         

Leu Lys Val Tyr Gly Ile Pro Glu His Val Met Ala Ala Arg Ala Ser 
        195                 200                 205             

Phe Pro Thr Ile Asn Asp Ala Val Glu Ala Val Ile Asn Ile Leu Gln 
    210                 215                 220                 

Ala Gly Ile Pro Ile Ala Arg Ile Glu Leu Val Asp Glu Leu Ser Met 
225                 230                 235                 240 

Lys Gln Val Asn His Tyr Ser Glu Thr Ser Tyr Arg Glu Glu Pro Thr 
                245                 250                 255     

Leu Phe Leu Glu Phe His Gly Asn Glu Ala Gly Leu Lys Gln Asp Val 
            260                 265                 270         

Glu Phe Thr Lys Glu Ile Val Phe Asp His Lys Cys Lys Glu Val Ala 
        275                 280                 285             

Phe Glu Thr Glu Thr Ala Ala Arg Asn Lys Leu Trp Asp Ala Arg His 
    290                 295                 300                 

Asn Leu Ala Tyr Ala Tyr Val His Ser Tyr Pro Gly Lys Lys Leu Met 
305                 310                 315                 320 

Ser Thr Asp Val Cys Val Pro Ile Ser Glu Leu Ala Gly Ala Ile Gln 
                325                 330                 335     

Gln Ala Lys Glu Thr Leu Glu Lys Asn Gly Leu Val Gly Gly Ile Leu 
            340                 345                 350         

Gly His Val Gly Asp Gly Asn Phe His Val Leu Leu Met Val Asp Pro 
        355                 360                 365             

Asn Asp Lys Glu Glu Val Glu Lys Ala Asp Lys Ile Asn Glu Ser Ile 
    370                 375                 380                 

Val Leu Tyr Ala Leu Lys Arg Gly Gly Thr Cys Thr Gly Glu His Gly 
385                 390                 395                 400 

Val Gly Ile Gly Lys Arg Lys Tyr Gln Glu Glu Glu His Gly Ala Ala 
                405                 410                 415     

Leu Leu Val Met Glu Lys Ile Lys Lys Ala Leu Asp Pro Gln Asn Ile 
            420                 425                 430         

Leu Asn Pro Asn Lys Val 
        435             

<210>   687
<211>   438
<212>   PRT
<213>   Bacillus weihenstephanensis KBAB4

<400>   687
Asp Gln Val Val Val Asn Lys Thr Val Arg Glu Leu His Ser Lys Asp 
                5                   10                  15      

Glu Ser Tyr His Asn Ser Ser Leu Pro Asp Val Val Val Phe Pro Lys 
            20                  25                  30          

Thr Thr Glu Glu Val Arg Ala Ile Met Lys Val Ala Ser Glu His Lys 
        35                  40                  45              

Lys Pro Val Ile Pro Phe Gly Val Gly Ser Ser Leu Glu Gly His Ile 
    50                  55                  60                  

Ile Pro Tyr Glu Lys Gly Ile Thr Val Asp Phe Ser Leu Met Asn Lys 
65                  70                  75                  80  

Ile Leu Glu Ile Arg Glu Lys Asp Phe Leu Val Lys Val Gln Pro Gly 
                85                  90                  95      

Val Thr Arg Ser Gln Leu Asn Lys Glu Leu Lys Lys Tyr Gly Leu Phe 
            100                 105                 110         

Phe Ser Val Asp Pro Gly Ala Asp Ala Thr Leu Gly Gly Met Ala Ala 
        115                 120                 125             

Thr Asn Ala Ser Gly Thr Thr Ala Val Arg Tyr Gly Val Met Arg Asp 
    130                 135                 140                 

Gln Val Arg Asp Leu Glu Val Val Leu Ala Asp Gly Gln Val Ile His 
145                 150                 155                 160 

Thr Gly Asn Leu Ala Ala Lys Ser Ser Ser Gly Tyr His Leu Asn Gly 
                165                 170                 175     

Ile Phe Val Gly Ser Glu Gly Thr Leu Gly Cys Phe Thr Glu Leu Thr 
            180                 185                 190         

Leu Lys Val Tyr Gly Ile Pro Glu His Val Met Ala Ala Arg Ala Ser 
        195                 200                 205             

Phe Pro Thr Ile Asn Asp Ala Val Glu Ala Val Ile Asn Ile Leu Gln 
    210                 215                 220                 

Ala Gly Ile Pro Ile Ala Arg Ile Glu Leu Val Asp Glu Leu Ser Met 
225                 230                 235                 240 

Lys Gln Val Asn His Tyr Asn Glu Thr Asn Tyr Arg Glu Glu Pro Thr 
                245                 250                 255     

Leu Phe Leu Glu Phe His Gly Asn Glu Ala Gly Leu Thr Gln Asp Ile 
            260                 265                 270         

Glu Phe Thr Lys Glu Ile Val Phe Asp His Lys Cys Lys Glu Val Ala 
        275                 280                 285             

Phe Glu Thr Glu Thr Val Ala Arg Asn Lys Leu Trp Asp Ala Arg His 
    290                 295                 300                 

Asn Leu Ala Tyr Ser Tyr Val His Ser Tyr Pro Gly Lys Lys Leu Met 
305                 310                 315                 320 

Ser Thr Asp Val Cys Val Pro Ile Ser Glu Leu Ala Gly Ala Ile Gln 
                325                 330                 335     

His Ala Lys Glu Thr Leu Asp Lys Val Gly Leu Val Gly Gly Ile Leu 
            340                 345                 350         

Gly His Val Gly Asp Gly Asn Phe His Val Leu Leu Met Ile Asn Pro 
        355                 360                 365             

Asn Asp Lys Asp Glu Val Lys Lys Ala Asp Glu Ile Asn Glu Ser Ile 
    370                 375                 380                 

Val Leu Tyr Ala Leu Lys Arg Gly Gly Thr Cys Thr Gly Glu His Gly 
385                 390                 395                 400 

Val Gly Ile Gly Lys Gln Lys Tyr Gln Glu Glu Glu His Gly Ala Ala 
                405                 410                 415     

Leu Leu Val Met Glu Lys Ile Lys Lys Ala Leu Asp Pro Gln Asn Ile 
            420                 425                 430         

Leu Asn Pro Asn Lys Ile 
        435             

<210>   688
<211>   489
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   688
Met Tyr Pro Phe Ser Ser Tyr Met Thr Phe Thr Arg Arg Val Ser Pro 
                5                   10                  15      

Trp Asp Arg Arg His Ala Arg Arg Arg Ala Thr Glu Met Glu Ala Arg 
            20                  25                  30          

Met Met Thr Ile Pro Trp Glu Thr Leu Lys Glu Glu Leu Gly Asp Lys 
        35                  40                  45              

Leu Ser Phe Gly Glu Ser Val Arg Arg Ser His Ala Lys Asp Glu Ser 
    50                  55                  60                  

Tyr His Pro Glu His Leu Pro Asp Ala Val Ala Tyr Pro Glu Glu Thr 
65                  70                  75                  80  

Ala Asp Val Val Ala Leu Ala Arg Phe Ser His Ala His Gly Val Pro 
                85                  90                  95      

Leu Val Ala Tyr Gly Ala Gly Ser Gly Leu Glu Gly Gln Val Ile Pro 
            100                 105                 110         

Val Arg Gly Gly Ile Ser Val Asp Phe Ser Arg Met Asn Arg Val Leu 
        115                 120                 125             

Glu Ile Arg Pro Asp Asp Phe Leu Val Cys Val Glu Pro Gly Val Thr 
    130                 135                 140                 

Arg Gln Gln Leu Asn Asp Ala Leu Arg Pro Tyr Gly Leu Met Phe Pro 
145                 150                 155                 160 

Val Asp Pro Gly Ala Asn Ala Ser Leu Gly Gly Met Ala Ala Thr Asn 
                165                 170                 175     

Ala Ser Gly Thr Thr Ala Val Arg Tyr Gly Pro Met Lys Ala Asn Val 
            180                 185                 190         

Arg Lys Leu Glu Val Val Leu Ala Asp Gly Lys Val Ile Glu Val Gly 
        195                 200                 205             

Thr Leu Ala Ala Lys Ser Ser Ser Gly Tyr Asn Leu Val Glu Leu Phe 
    210                 215                 220                 

Val Gly Ser Glu Gly Thr Leu Gly Leu Phe Thr Lys Leu Trp Leu Arg 
225                 230                 235                 240 

Val Tyr Gly Val Pro Glu Ala Thr Leu Ala Ala Ser Ala Glu Phe Ala 
                245                 250                 255     

Thr Val Arg Glu Ala Val Asp Ala Val Cys Met Leu Ile Gly Ser Gly 
            260                 265                 270         

Leu Gln Leu Thr Arg Cys Glu Leu Val Thr Lys Pro Tyr Ile Glu Ile 
        275                 280                 285             

Ile Asn Arg Gln Phe Asp Thr Ser Tyr Thr Pro Ala Pro Thr Leu Phe 
    290                 295                 300                 

Leu Glu Leu Ser Gly Ser Gln Ala Ala Val Gln Ala Asp Met Gly Thr 
305                 310                 315                 320 

Val Asp Glu Ile Leu Arg Asp Ala Gly Ala Ala Arg Val Ser Val Val 
                325                 330                 335     

Met Asp Glu Arg Glu Arg Gln Lys Leu Trp His Ala Arg His Asn Ala 
            340                 345                 350         

Ala Tyr Ala Leu Met Arg Thr Tyr Pro Gly Leu Ser His Leu Ser Thr 
        355                 360                 365             

Asp Val Cys Val Pro Met Ser Lys Leu Pro Glu Ala Val Asp Val Ala 
    370                 375                 380                 

Glu Thr Trp Ile Glu Arg Leu Gly Ile Arg Gly Gly Ile Val Gly His 
385                 390                 395                 400 

Val Gly Asp Gly Asn Phe His Val Ser Leu Met Val Asn Pro Ser Asp 
                405                 410                 415     

Pro Asp Asp Leu Gly Arg Ala Tyr Glu Leu Ser His His Leu Val Glu 
            420                 425                 430         

Tyr Ala Leu Ser Val Gly Gly Thr Cys Thr Gly Glu His Gly Val Gly 
        435                 440                 445             

Leu Gly Lys Met Lys Tyr Gln Lys Gln Glu His Gly Glu Ala Leu Ala 
    450                 455                 460                 

Leu Met Gln Ala Val Lys Arg Leu Phe Asp Pro Ala Asp Met Leu Asn 
465                 470                 475                 480 

Pro Gly Lys Leu Val Asp Gly Ile Ala 
                485                 

<210>   689
<211>   489
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   689
Met Tyr Pro Phe Ser Ser Tyr Met Thr Phe Thr Arg Arg Val Ser Pro 
                5                   10                  15      

Trp Asp Arg Arg His Ala Arg Arg Arg Ala Thr Glu Met Glu Ala Arg 
            20                  25                  30          

Met Met Thr Ile Pro Trp Glu Thr Leu Lys Glu Glu Leu Gly Asp Lys 
        35                  40                  45              

Leu Ser Phe Gly Glu Ser Val Arg Arg Ser His Ala Lys Asp Glu Ser 
    50                  55                  60                  

Tyr His Pro Glu His Leu Pro Asp Ala Val Ala Tyr Pro Glu Glu Thr 
65                  70                  75                  80  

Ala Asp Val Val Ala Leu Ala Arg Phe Ser His Ala His Gly Val Pro 
                85                  90                  95      

Leu Val Ala Tyr Gly Ala Gly Ser Gly Leu Glu Gly Gln Val Ile Pro 
            100                 105                 110         

Val Arg Gly Gly Ile Ser Val Asp Phe Ser Arg Met Asn Arg Val Leu 
        115                 120                 125             

Glu Ile Arg Pro Asp Asp Phe Leu Val Cys Val Glu Pro Gly Val Thr 
    130                 135                 140                 

Arg Gln Gln Leu Asn Asp Ala Leu Arg Pro Tyr Gly Leu Met Phe Pro 
145                 150                 155                 160 

Val Asp Pro Gly Ala Asn Ala Ser Leu Gly Gly Met Ala Ala Thr Asn 
                165                 170                 175     

Ala Ser Gly Thr Thr Ala Val Arg Tyr Gly Pro Met Lys Ala Asn Val 
            180                 185                 190         

Arg Lys Leu Glu Val Val Leu Ala Asp Gly Arg Val Ile Glu Val Gly 
        195                 200                 205             

Thr Leu Ala Ala Lys Ser Ser Ser Gly Tyr Asn Leu Val Glu Leu Phe 
    210                 215                 220                 

Val Gly Ser Glu Gly Thr Leu Gly Leu Phe Thr Lys Leu Trp Leu Arg 
225                 230                 235                 240 

Val Tyr Gly Val Pro Glu Ala Thr Leu Ala Ala Ser Ala Glu Phe Ala 
                245                 250                 255     

Thr Val Arg Glu Ala Val Asp Ala Val Cys Met Leu Ile Gly Ser Gly 
            260                 265                 270         

Leu Gln Leu Thr Arg Cys Glu Leu Val Thr Lys Pro Tyr Ile Glu Ile 
        275                 280                 285             

Ile Asn Arg Gln Phe Asp Thr Ser Tyr Thr Pro Ala Pro Thr Leu Phe 
    290                 295                 300                 

Leu Glu Leu Ser Gly Ser Gln Ala Ala Val Gln Ala Asp Met Gly Thr 
305                 310                 315                 320 

Val Asp Glu Ile Leu Arg Asp Ala Gly Ala Ala Arg Val Ser Val Val 
                325                 330                 335     

Met Asp Asp Arg Glu Arg Gln Lys Leu Trp His Ala Arg His Asn Ala 
            340                 345                 350         

Ala Tyr Ala Leu Met Arg Thr Tyr Pro Gly Leu Ser His Leu Ser Thr 
        355                 360                 365             

Asp Val Cys Val Pro Met Ser Lys Leu Pro Glu Ala Val Asp Val Ala 
    370                 375                 380                 

Glu Thr Trp Ile Glu Arg Leu Gly Ile Arg Gly Gly Ile Val Gly His 
385                 390                 395                 400 

Val Gly Asp Gly Asn Phe His Val Ser Leu Met Val Asn Pro Ser Asp 
                405                 410                 415     

Pro Asp Asp Leu Gly Arg Ala Tyr Glu Leu Ser His His Leu Val Glu 
            420                 425                 430         

Tyr Ala Leu Ser Val Gly Gly Thr Cys Thr Gly Glu His Gly Val Gly 
        435                 440                 445             

Leu Gly Lys Met Lys Tyr Gln Lys Gln Glu His Gly Glu Ala Leu Ala 
    450                 455                 460                 

Leu Met Gln Ala Val Lys Arg Leu Phe Asp Pro Ala Asp Met Leu Asn 
465                 470                 475                 480 

Pro Gly Lys Leu Val Asp Gly Ile Ala 
                485                 

<210>   690
<211>   489
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   690
Met Tyr Pro Phe Ser Ser Tyr Met Thr Phe Thr Arg Arg Val Ser Pro 
                5                   10                  15      

Trp Asp Arg Arg His Ala Arg Arg Arg Ala Thr Glu Met Glu Ala Arg 
            20                  25                  30          

Met Met Thr Ile Pro Trp Glu Thr Leu Lys Glu Glu Leu Gly Asp Lys 
        35                  40                  45              

Leu Ser Phe Gly Glu Ser Val Arg Arg Ser His Ala Lys Asp Glu Ser 
    50                  55                  60                  

Tyr His Pro Glu His Leu Pro Asp Ala Val Ala Tyr Pro Glu Glu Thr 
65                  70                  75                  80  

Ala Asp Val Val Ala Leu Ala Arg Phe Ser His Ala His Gly Val Pro 
                85                  90                  95      

Leu Val Ala Tyr Gly Ala Gly Ser Gly Leu Glu Gly Gln Val Ile Pro 
            100                 105                 110         

Val Arg Gly Gly Ile Ser Val Asp Phe Ser Arg Met Asn Arg Val Leu 
        115                 120                 125             

Glu Ile Arg Pro Asp Asp Phe Leu Val Cys Val Glu Pro Gly Val Thr 
    130                 135                 140                 

Arg Gln Gln Leu Asn Asp Ala Leu Arg Pro Tyr Gly Leu Met Phe Pro 
145                 150                 155                 160 

Val Asp Pro Gly Ala Asn Ala Ser Leu Gly Gly Met Ala Ala Thr Asn 
                165                 170                 175     

Ala Ser Gly Thr Thr Ala Val Arg Tyr Gly Pro Met Lys Ala Asn Val 
            180                 185                 190         

Arg Lys Leu Glu Val Val Leu Ala Asp Gly Arg Val Ile Glu Val Gly 
        195                 200                 205             

Thr Leu Ala Ala Lys Ser Ser Ser Gly Tyr Asn Leu Val Glu Leu Phe 
    210                 215                 220                 

Val Gly Ser Glu Gly Thr Leu Gly Leu Phe Thr Lys Leu Trp Leu Arg 
225                 230                 235                 240 

Val Tyr Gly Val Pro Glu Ala Thr Leu Ala Ala Ser Ala Glu Phe Ala 
                245                 250                 255     

Thr Val Arg Glu Ala Val Asp Ala Val Cys Met Leu Ile Gly Ser Gly 
            260                 265                 270         

Leu Gln Leu Thr Arg Cys Glu Leu Val Thr Lys Pro Tyr Ile Glu Ile 
        275                 280                 285             

Ile Asn Arg Gln Phe Asp Thr Ser Tyr Thr Pro Ala Pro Thr Leu Phe 
    290                 295                 300                 

Leu Glu Leu Ser Gly Ser Gln Ala Ala Val Gln Ala Asp Met Gly Thr 
305                 310                 315                 320 

Val Asp Glu Ile Leu Arg Asp Ala Gly Ala Ala Arg Val Ser Val Val 
                325                 330                 335     

Met Asp Glu Arg Glu Arg Gln Lys Leu Trp His Ala Arg His Asn Ala 
            340                 345                 350         

Ala Tyr Ala Leu Met Arg Thr Tyr Pro Gly Leu Ser His Leu Ser Thr 
        355                 360                 365             

Asp Val Cys Val Pro Met Ser Lys Leu Pro Glu Ala Val Asp Ile Ala 
    370                 375                 380                 

Glu Thr Trp Ile Glu Arg Leu Gly Ile Arg Gly Gly Ile Val Gly His 
385                 390                 395                 400 

Val Gly Asp Gly Asn Phe His Val Ser Leu Met Val Asn Pro Ser Asp 
                405                 410                 415     

Pro Asp Asp Leu Gly Arg Ala Tyr Glu Leu Ser His His Leu Val Glu 
            420                 425                 430         

Tyr Ala Leu Ser Val Gly Gly Thr Cys Thr Gly Glu His Gly Val Gly 
        435                 440                 445             

Leu Gly Lys Met Lys Tyr Gln Lys Gln Glu His Gly Glu Ala Leu Ala 
    450                 455                 460                 

Leu Met Gln Ala Val Lys Arg Leu Phe Asp Pro Ala Asp Met Leu Asn 
465                 470                 475                 480 

Pro Gly Lys Leu Val Asp Gly Ile Ala 
                485                 

<210>   691
<211>   489
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   691
Met Tyr Pro Phe Ser Ser Tyr Met Thr Phe Thr Arg Arg Val Ser Pro 
                5                   10                  15      

Trp Asp Arg Arg His Ala Lys Arg Arg Ala Thr Glu Met Glu Ala Arg 
            20                  25                  30          

Met Met Thr Ile Pro Trp Glu Thr Leu Lys Glu Glu Leu Gly Asp Lys 
        35                  40                  45              

Leu Ser Phe Gly Glu Ser Val Arg Arg Ser His Ala Lys Asp Glu Ser 
    50                  55                  60                  

Tyr His Pro Glu His Leu Pro Asp Ala Val Ala Tyr Pro Glu Glu Thr 
65                  70                  75                  80  

Ala Asp Val Val Ala Leu Ala Arg Phe Ser His Ala His Gly Val Pro 
                85                  90                  95      

Leu Val Ala Tyr Gly Ala Gly Ser Gly Leu Glu Gly Gln Val Ile Pro 
            100                 105                 110         

Val Arg Gly Gly Ile Ser Val Asp Phe Ser Arg Met Asn Arg Val Leu 
        115                 120                 125             

Glu Ile Arg Pro Asp Asp Phe Leu Val Cys Val Glu Pro Gly Val Thr 
    130                 135                 140                 

Arg Gln Gln Leu Asn Asp Ala Leu Arg Pro Tyr Gly Leu Met Phe Pro 
145                 150                 155                 160 

Val Asp Pro Gly Ala Asn Ala Ser Leu Gly Gly Met Ala Ala Thr Asn 
                165                 170                 175     

Ala Ser Gly Thr Thr Ala Val Arg Tyr Gly Pro Met Lys Ala Asn Val 
            180                 185                 190         

Arg Lys Leu Glu Val Val Leu Ala Asp Gly Arg Val Ile Glu Val Gly 
        195                 200                 205             

Thr Leu Ala Ala Lys Ser Ser Ser Gly Tyr Asn Leu Val Glu Leu Phe 
    210                 215                 220                 

Val Gly Ser Glu Gly Thr Leu Gly Leu Phe Thr Lys Leu Trp Leu Arg 
225                 230                 235                 240 

Val Tyr Gly Val Pro Glu Ala Thr Leu Ala Ala Ser Ala Glu Phe Ala 
                245                 250                 255     

Thr Val Arg Glu Ala Val Asp Ala Val Cys Met Leu Ile Gly Ser Gly 
            260                 265                 270         

Leu Gln Leu Thr Arg Cys Glu Leu Val Thr Lys Pro Tyr Ile Glu Ile 
        275                 280                 285             

Ile Asn Arg Gln Phe Asp Thr Ser Tyr Thr Pro Ala Pro Thr Leu Phe 
    290                 295                 300                 

Leu Glu Leu Ser Gly Ser Gln Ala Ala Val Gln Ala Asp Met Gly Thr 
305                 310                 315                 320 

Val Asp Glu Ile Leu Arg Asp Ala Gly Ala Ala Arg Val Ser Val Val 
                325                 330                 335     

Met Asp Glu Arg Glu Arg Gln Lys Leu Trp His Ala Arg His Asn Ala 
            340                 345                 350         

Ala Tyr Ala Leu Met Arg Thr Tyr Pro Gly Leu Ser His Leu Ser Thr 
        355                 360                 365             

Asp Val Cys Val Pro Met Ser Lys Leu Pro Glu Ala Val Asp Val Ala 
    370                 375                 380                 

Glu Thr Trp Ile Glu Arg Leu Gly Ile Arg Gly Gly Ile Val Gly His 
385                 390                 395                 400 

Val Gly Asp Gly Asn Phe His Val Ser Leu Met Val Asn Pro Ser Asp 
                405                 410                 415     

Pro Asp Asp Leu Gly Arg Ala Tyr Glu Leu Ser His His Leu Val Glu 
            420                 425                 430         

Tyr Ala Leu Ser Val Gly Gly Thr Cys Thr Gly Glu His Gly Val Gly 
        435                 440                 445             

Leu Gly Lys Met Lys Tyr Gln Lys Gln Glu His Gly Glu Ala Leu Ala 
    450                 455                 460                 

Leu Met Gln Ala Val Lys Arg Leu Phe Asp Pro Ala Asp Met Leu Asn 
465                 470                 475                 480 

Pro Gly Lys Leu Val Asp Gly Ile Ala 
                485                 

<210>   692
<211>   489
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   692
Met Tyr Pro Phe Ser Ser Tyr Met Thr Phe Thr Arg Arg Val Ser Pro 
                5                   10                  15      

Trp Asp Arg Arg His Ala Arg Arg Arg Ala Thr Glu Met Glu Ala Arg 
            20                  25                  30          

Met Met Thr Ile Pro Trp Glu Thr Leu Lys Glu Glu Leu Gly Asp Lys 
        35                  40                  45              

Leu Ser Phe Gly Glu Ser Val Arg Arg Ser His Ala Lys Asp Glu Ser 
    50                  55                  60                  

Tyr His Pro Glu His Leu Pro Asp Ala Val Ala Tyr Pro Glu Glu Thr 
65                  70                  75                  80  

Ala Asp Val Val Ala Leu Ala Arg Phe Ser His Ala His Gly Val Pro 
                85                  90                  95      

Leu Val Ala Tyr Gly Ala Gly Ser Gly Leu Glu Gly Gln Val Ile Pro 
            100                 105                 110         

Val Arg Gly Gly Ile Ser Val Asp Phe Ser Arg Met Asn Arg Val Leu 
        115                 120                 125             

Glu Ile Arg Pro Asp Asp Phe Leu Val Cys Val Glu Pro Gly Val Thr 
    130                 135                 140                 

Arg Gln Gln Leu Asn Asp Ala Leu Arg Pro Tyr Gly Leu Met Phe Pro 
145                 150                 155                 160 

Val Asp Pro Gly Ala Asn Ala Ser Leu Gly Gly Met Ala Ala Thr Asn 
                165                 170                 175     

Ala Ser Gly Thr Thr Ala Val Arg Tyr Gly Pro Met Lys Ala Asn Val 
            180                 185                 190         

Arg Lys Leu Glu Val Val Leu Ala Asp Gly Arg Val Ile Glu Val Gly 
        195                 200                 205             

Thr Leu Ala Ala Lys Ser Ser Ser Gly Tyr Asn Leu Val Glu Leu Phe 
    210                 215                 220                 

Val Gly Ser Glu Gly Thr Leu Gly Ile Phe Thr Lys Leu Trp Leu Arg 
225                 230                 235                 240 

Val Tyr Gly Val Pro Glu Ala Thr Leu Ala Ala Ser Ala Glu Phe Ala 
                245                 250                 255     

Thr Val Arg Glu Ala Val Asp Ala Val Cys Met Leu Ile Gly Ser Gly 
            260                 265                 270         

Leu Gln Leu Thr Arg Cys Glu Leu Val Thr Lys Pro Tyr Ile Glu Ile 
        275                 280                 285             

Ile Asn Arg Gln Phe Asp Thr Ser Tyr Thr Pro Ala Pro Thr Leu Phe 
    290                 295                 300                 

Leu Glu Leu Ser Gly Ser Gln Ala Ala Val Gln Ala Asp Met Gly Thr 
305                 310                 315                 320 

Val Asp Glu Ile Leu Arg Asp Ala Gly Ala Ala Arg Val Ser Val Val 
                325                 330                 335     

Met Asp Glu Arg Glu Arg Gln Lys Leu Trp His Ala Arg His Asn Ala 
            340                 345                 350         

Ala Tyr Ala Leu Met Arg Thr Tyr Pro Gly Leu Ser His Leu Ser Thr 
        355                 360                 365             

Asp Val Cys Val Pro Met Ser Lys Leu Pro Glu Ala Val Asp Val Ala 
    370                 375                 380                 

Glu Thr Trp Ile Glu Arg Leu Gly Ile Arg Gly Gly Ile Val Gly His 
385                 390                 395                 400 

Val Gly Asp Gly Asn Phe His Val Ser Leu Met Val Asn Pro Ser Asp 
                405                 410                 415     

Pro Asp Asp Leu Gly Arg Ala Tyr Glu Leu Ser His His Leu Val Glu 
            420                 425                 430         

Tyr Ala Leu Ser Val Gly Gly Thr Cys Thr Gly Glu His Gly Val Gly 
        435                 440                 445             

Leu Gly Lys Met Lys Tyr Gln Lys Gln Glu His Gly Glu Ala Leu Ala 
    450                 455                 460                 

Leu Met Gln Ala Val Lys Arg Leu Phe Asp Pro Ala Asp Met Leu Asn 
465                 470                 475                 480 

Pro Gly Lys Leu Val Asp Gly Ile Ala 
                485                 

<210>   693
<211>   1470
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   693
atgtatccct tttcatccta tatgaccttt acgcggcgcg taagcccctg ggacaggcgc       60

catgcgcgca ggcgtgcgac agaaatggag gcccggatga tgaccatccc ttgggagacg      120

ttgaaagagg agctcggcga caagctcagc ttcggcgaga gcgttcgccg atcgcacgcg      180

aaggacgaat cgtatcaccc ggagcacctg ccggacgccg tggcctatcc ggaggagacg      240

gcggatgtcg tggcacttgc gcggttttcg catgcgcacg gggtgccgct cgtcgcttac      300

ggcgccggat cgggcctcga gggccaggtc atccccgtgc gcggcggcat ctcggtcgac      360

ttttcgcgga tgaaccgcgt gctcgagatc cggccggacg acttcctcgt ctgcgtcgag      420

cccggcgtca cgcgccagca gttgaacgac gccctgcgcc cgtacggcct catgtttccg      480

gtcgatcccg gcgccaacgc gtccttgggc ggcatggcgg cgacgaacgc gagcggcacg      540

acggcggtgc ggtatggccc gatgaaggcg aacgtgcgga agctcgaggt ggtgctcgcg      600

gatgggaaag tgatcgaggt gggaacgctc gccgccaaat ccagctccgg ctataatctc      660

gtcgaactct tcgtgggctc ggaaggcacg ctaggcttgt tcacgaagct ctggctccgc      720

gtctacggtg tgcccgaggc gacgctcgcc gcctccgcgg agtttgcgac ggtccgcgag      780

gcggtggacg ccgtgtgcat gctcatcggc agcgggctcc agctcacgcg ttgcgaactt      840

gtgacaaagc cgtacatcga gatcatcaac cgccagtttg acacgtccta cacgcccgcg      900

ccgaccctgt tcctcgagct gtcgggctct caggccgcgg tgcaggccga catggggacg      960

gtcgacgaga tcctgcgcga cgccggcgca gcccgcgtct ccgtcgtcat ggatgagcgc     1020

gaacgccaga agctttggca cgcgcggcac aacgcggcgt atgcgctcat gcggacctac     1080

ccagggctgt cgcacctctc gacggacgtg tgcgtgccca tgtcgaagct gcccgaggca     1140

gtcgacgtgg cggagacgtg gatcgagcgg ctcgggatcc gcgggggcat cgtggggcac     1200

gtcggcgacg gcaacttcca cgtcagcctg atggtcaacc cgagcgaccc ggacgatctc     1260

ggccgcgcct acgagctctc gcaccacctg gtcgagtacg cgctgtccgt cggcggcacg     1320

tgcacgggcg agcacggcgt cgggctcggc aagatgaagt atcagaagca ggagcacggc     1380

gaggcgctcg ccctgatgca ggcggtgaag cggctgttcg atccggccga catgctcaac     1440

cccgggaagc tggtcgacgg gatcgcgtga                                      1470


<210>   694
<211>   1470
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   694
atgtatccct tttcatccta tatgaccttt acgcggcgcg taagcccctg ggacaggcgc       60

catgcgcgca ggcgtgcgac agaaatggag gcccggatga tgaccatccc ttgggagacg      120

ttgaaagagg agctcggcga caagctcagc ttcggcgaga gcgttcgccg atcgcacgcg      180

aaggacgaat cgtatcaccc ggagcacctg ccggacgccg tggcctatcc ggaggagacg      240

gcggatgtcg tggcacttgc gcggttttcg catgcgcacg gggtgccgct cgtcgcttac      300

ggcgccggat cgggcctcga gggccaggtc atccccgtgc gcggcggcat ctcggtcgac      360

ttttcgcgga tgaaccgcgt gctcgagatc cggccggacg acttcctcgt ctgcgtcgag      420

cccggcgtca cgcgccagca gttgaacgac gccctgcgcc cgtacggcct catgtttccg      480

gtcgatcccg gcgccaacgc gtccttgggc ggcatggcgg cgacgaacgc gagcggcacg      540

acggcggtgc ggtatggccc gatgaaggcg aacgtgcgga agctcgaggt ggtgctcgcg      600

gatgggcgcg tgatcgaggt gggaacgctc gccgccaaat ccagctccgg ctataatctc      660

gtcgaactct tcgtgggctc ggaaggcacg ctaggcttgt tcacgaagct ctggctccgc      720

gtctacggtg tgcccgaggc gacgctcgcc gcctccgcgg agtttgcgac ggtccgcgag      780

gcggtggacg ccgtgtgcat gctcatcggc agcgggctcc agctcacgcg ttgcgaactt      840

gtgacaaagc cgtacatcga gatcatcaac cgccagtttg acacgtccta cacgcccgcg      900

ccgaccctgt tcctcgagct gtcgggctct caggccgcgg tgcaggccga catggggacg      960

gtcgacgaga tcctgcgcga cgccggcgca gcccgcgtct ccgtcgtcat ggatgatcgc     1020

gaacgccaga agctttggca cgcgcggcac aacgcggcgt atgcgctcat gcggacctac     1080

ccagggctgt cgcacctctc gacggacgtg tgcgtgccca tgtcgaagct gcccgaggca     1140

gtcgacgtgg cggagacgtg gatcgagcgg ctcgggatcc gcgggggcat cgtggggcac     1200

gtcggcgacg gcaacttcca cgtcagcctg atggtcaacc cgagcgaccc ggacgatctc     1260

ggccgcgcct acgagctctc gcaccacctg gtcgagtacg cgctgtccgt cggcggcacg     1320

tgcacgggcg agcacggcgt cgggctcggc aagatgaagt atcagaagca ggagcacggc     1380

gaggcgctcg ccctgatgca ggcggtgaag cggctgttcg atccggccga catgctcaac     1440

cccgggaagc tggtcgacgg gatcgcgtga                                      1470


<210>   695
<211>   1470
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   695
atgtatccct tttcatccta tatgaccttt acgcggcgcg taagcccctg ggacaggcgc       60

catgcgcgca ggcgtgcgac agaaatggag gcccggatga tgaccatccc ttgggagacg      120

ttgaaagagg agctcggcga caagctcagc ttcggcgaga gcgttcgccg atcgcacgcg      180

aaggacgaat cgtatcaccc ggagcacctg ccggacgccg tggcctatcc ggaggagacg      240

gcggatgtcg tggcacttgc gcggttttcg catgcgcacg gggtgccgct cgtcgcttac      300

ggcgccggat cgggcctcga gggccaggtc atccccgtgc gcggcggcat ctcggtcgac      360

ttttcgcgga tgaaccgcgt gctcgagatc cggccggacg acttcctcgt ctgcgtcgag      420

cccggcgtca cgcgccagca gttgaacgac gccctgcgcc cgtacggcct catgtttccg      480

gtcgatcccg gcgccaacgc gtccttgggc ggcatggcgg cgacgaacgc gagcggcacg      540

acggcggtgc ggtatggccc gatgaaggcg aacgtgcgga agctcgaggt ggtgctcgcg      600

gatgggcgcg tgatcgaggt gggaacgctc gccgccaaat ccagctccgg ctataatctc      660

gtcgaactct tcgtgggctc ggaaggcacg ctaggcttgt tcacgaagct ctggctccgc      720

gtctacggtg tgcccgaggc gacgctcgcc gcctccgcgg agtttgcgac ggtccgcgag      780

gcggtggacg ccgtgtgcat gctcatcggc agcgggctcc agctcacgcg ttgcgaactt      840

gtgacaaagc cgtacatcga gatcatcaac cgccagtttg acacgtccta cacgcccgcg      900

ccgaccctgt tcctcgagct gtcgggctct caggccgcgg tgcaggccga catggggacg      960

gtcgacgaga tcctgcgcga cgccggcgca gcccgcgtct ccgtcgtcat ggatgagcgc     1020

gaacgccaga agctttggca cgcgcggcac aacgcggcgt atgcgctcat gcggacctac     1080

ccagggctgt cgcacctctc gacggacgtg tgcgtgccca tgtcgaagct gcccgaggca     1140

gtcgacattg cggagacgtg gatcgagcgg ctcgggatcc gcgggggcat cgtggggcac     1200

gtcggcgacg gcaacttcca cgtcagcctg atggtcaacc cgagcgaccc ggacgatctc     1260

ggccgcgcct acgagctctc gcaccacctg gtcgagtacg cgctgtccgt cggcggcacg     1320

tgcacgggcg agcacggcgt cgggctcggc aagatgaagt atcagaagca ggagcacggc     1380

gaggcgctcg ccctgatgca ggcggtgaag cggctgttcg atccggccga catgctcaac     1440

cccgggaagc tggtcgacgg gatcgcgtga                                      1470


<210>   696
<211>   1470
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   696
atgtatccct tttcatccta tatgaccttt acgcggcgcg taagcccctg ggacaggcgc       60

catgcgaaaa ggcgtgcgac agaaatggag gcccggatga tgaccatccc ttgggagacg      120

ttgaaagagg agctcggcga caagctcagc ttcggcgaga gcgttcgccg atcgcacgcg      180

aaggacgaat cgtatcaccc ggagcacctg ccggacgccg tggcctatcc ggaggagacg      240

gcggatgtcg tggcacttgc gcggttttcg catgcgcacg gggtgccgct cgtcgcttac      300

ggcgccggat cgggcctcga gggccaggtc atccccgtgc gcggcggcat ctcggtcgac      360

ttttcgcgga tgaaccgcgt gctcgagatc cggccggacg acttcctcgt ctgcgtcgag      420

cccggcgtca cgcgccagca gttgaacgac gccctgcgcc cgtacggcct catgtttccg      480

gtcgatcccg gcgccaacgc gtccttgggc ggcatggcgg cgacgaacgc gagcggcacg      540

acggcggtgc ggtatggccc gatgaaggcg aacgtgcgga agctcgaggt ggtgctcgcg      600

gatgggcgcg tgatcgaggt gggaacgctc gccgccaaat ccagctccgg ctataatctc      660

gtcgaactct tcgtgggctc ggaaggcacg ctaggcttgt tcacgaagct ctggctccgc      720

gtctacggtg tgcccgaggc gacgctcgcc gcctccgcgg agtttgcgac ggtccgcgag      780

gcggtggacg ccgtgtgcat gctcatcggc agcgggctcc agctcacgcg ttgcgaactt      840

gtgacaaagc cgtacatcga gatcatcaac cgccagtttg acacgtccta cacgcccgcg      900

ccgaccctgt tcctcgagct gtcgggctct caggccgcgg tgcaggccga catggggacg      960

gtcgacgaga tcctgcgcga cgccggcgca gcccgcgtct ccgtcgtcat ggatgagcgc     1020

gaacgccaga agctttggca cgcgcggcac aacgcggcgt atgcgctcat gcggacctac     1080

ccagggctgt cgcacctctc gacggacgtg tgcgtgccca tgtcgaagct gcccgaggca     1140

gtcgacgtgg cggagacgtg gatcgagcgg ctcgggatcc gcgggggcat cgtggggcac     1200

gtcggcgacg gcaacttcca cgtcagcctg atggtcaacc cgagcgaccc ggacgatctc     1260

ggccgcgcct acgagctctc gcaccacctg gtcgagtacg cgctgtccgt cggcggcacg     1320

tgcacgggcg agcacggcgt cgggctcggc aagatgaagt atcagaagca ggagcacggc     1380

gaggcgctcg ccctgatgca ggcggtgaag cggctgttcg atccggccga catgctcaac     1440

cccgggaagc tggtcgacgg gatcgcgtga                                      1470


<210>   697
<211>   1470
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   697
atgtatccct tttcatccta tatgaccttt acgcggcgcg taagcccctg ggacaggcgc       60

catgcgcgca ggcgtgcgac agaaatggag gcccggatga tgaccatccc ttgggagacg      120

ttgaaagagg agctcggcga caagctcagc ttcggcgaga gcgttcgccg atcgcacgcg      180

aaggacgaat cgtatcaccc ggagcacctg ccggacgccg tggcctatcc ggaggagacg      240

gcggatgtcg tggcacttgc gcggttttcg catgcgcacg gggtgccgct cgtcgcttac      300

ggcgccggat cgggcctcga gggccaggtc atccccgtgc gcggcggcat ctcggtcgac      360

ttttcgcgga tgaaccgcgt gctcgagatc cggccggacg acttcctcgt ctgcgtcgag      420

cccggcgtca cgcgccagca gttgaacgac gccctgcgcc cgtacggcct catgtttccg      480

gtcgatcccg gcgccaacgc gtccttgggc ggcatggcgg cgacgaacgc gagcggcacg      540

acggcggtgc ggtatggccc gatgaaggcg aacgtgcgga agctcgaggt ggtgctcgcg      600

gatgggcgcg tgatcgaggt gggaacgctc gccgccaaat ccagctccgg ctataatctc      660

gtcgaactct tcgtgggctc ggaaggcacg ctaggcattt tcacgaagct ctggctccgc      720

gtctacggtg tgcccgaggc gacgctcgcc gcctccgcgg agtttgcgac ggtccgcgag      780

gcggtggacg ccgtgtgcat gctcatcggc agcgggctcc agctcacgcg ttgcgaactt      840

gtgacaaagc cgtacatcga gatcatcaac cgccagtttg acacgtccta cacgcccgcg      900

ccgaccctgt tcctcgagct gtcgggctct caggccgcgg tgcaggccga catggggacg      960

gtcgacgaga tcctgcgcga cgccggcgca gcccgcgtct ccgtcgtcat ggatgagcgc     1020

gaacgccaga agctttggca cgcgcggcac aacgcggcgt atgcgctcat gcggacctac     1080

ccagggctgt cgcacctctc gacggacgtg tgcgtgccca tgtcgaagct gcccgaggca     1140

gtcgacgtgg cggagacgtg gatcgagcgg ctcgggatcc gcgggggcat cgtggggcac     1200

gtcggcgacg gcaacttcca cgtcagcctg atggtcaacc cgagcgaccc ggacgatctc     1260

ggccgcgcct acgagctctc gcaccacctg gtcgagtacg cgctgtccgt cggcggcacg     1320

tgcacgggcg agcacggcgt cgggctcggc aagatgaagt atcagaagca ggagcacggc     1380

gaggcgctcg ccctgatgca ggcggtgaag cggctgttcg atccggccga catgctcaac     1440

cccgggaagc tggtcgacgg gatcgcgtga                                      1470


<210>   698
<211>   388
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   698
Met Met Arg Thr Leu Asp Glu Trp Lys Lys Asp Val Asp Ala Tyr Val 
                5                   10                  15      

Ala Gly Pro Ala Arg Ala Trp Ser Glu His Ile Glu Ala Thr Gly Thr 
            20                  25                  30          

Val Pro Asp Ala Leu Trp Arg Glu Leu Arg Asp Ala Gly Tyr Leu Arg 
        35                  40                  45              

Leu Ala Ala Pro Pro His Leu Gly Gly His Gly Leu Ser Phe Thr Asp 
    50                  55                  60                  

Tyr Leu Asp Leu Leu Arg Arg Phe Ala His Thr His Gly Ser Ile Arg 
65                  70                  75                  80  

Val Met Val His Val Ala Asn Ser Leu Trp Arg Ser Leu Ala Gln Lys 
                85                  90                  95      

Ala Thr Pro Glu Gln Val Glu Arg Phe Val Lys Pro Phe Val Ala Gly 
            100                 105                 110         

Asp Ile Arg Val Thr Phe Thr Leu Thr Glu Pro Asn Ser Gly Ser Gly 
        115                 120                 125             

Ala Asp Ile Lys Thr Thr Ala Arg Arg Glu Gly Asp Glu Tyr Val Leu 
    130                 135                 140                 

Asn Gly Glu Lys Trp Met Ile Ile Phe Ser Asp Val Ala Asp Tyr Phe 
145                 150                 155                 160 

Leu Leu Phe Cys Arg Leu Glu Gly Thr Ser Gly Gly Glu Gly Thr Leu 
                165                 170                 175     

Ala Leu Leu Val Pro Arg Asp Ala Pro Gly Leu Thr Val Glu Leu Met 
            180                 185                 190         

Ala Pro Ala Met Gly Ile Ala Gly Thr Ala His Gly His Leu Arg Leu 
        195                 200                 205             

Arg Asp Cys Arg Val Pro Val Ala Asn Arg Leu Gly Glu Glu Gly Asp 
    210                 215                 220                 

Gly Leu Glu Val Ala Phe Arg Gly Phe Leu Asp Pro Ser Arg Thr Ala 
225                 230                 235                 240 

Ile Gly Met Thr Cys Val Gly Ala Ala Glu Arg Ala Leu Glu Leu Ala 
                245                 250                 255     

Ala Asp His Ala Leu Arg Arg Val Thr Phe Gly Gln Pro Leu Ala Lys 
            260                 265                 270         

Arg Gln Ile Ile Gln Met Trp Leu Ala Glu Met Ala Thr Asp Ile Glu 
        275                 280                 285             

Ala Ala Arg Gln Leu Val Leu His Ala Ala Arg Arg Phe Asp Glu Gly 
    290                 295                 300                 

His Pro Ile Thr Val Glu Ala Ala Met Ala Lys Met Phe Ala Thr Glu 
305                 310                 315                 320 

Met Leu Gln Arg Val Thr Asp Lys Ala Leu Gln Ile His Gly Gly Pro 
                325                 330                 335     

Gly Tyr Phe Lys Ser Ser Glu Ile Glu Arg Ile Tyr Arg Asp Ala Arg 
            340                 345                 350         

Met Gln Arg Phe Glu Glu Gly Thr Ser Glu Ile Gln Lys Met Val Ile 
        355                 360                 365             

Ala Arg Asp Val Ile Asp Lys Ala Lys Arg Ala Ser Glu Gly Ser Glu 
    370                 375                 380                 

Arg Arg Cys Trp 
385             

<210>   699
<211>   1167
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   699
atgatgcgga cgctggacga gtggaagaag gacgtcgacg cttacgtcgc gggcccggcc       60

agggcgtggt ctgagcatat tgaggcgacg gggacggtgc cggacgccct gtggcgagag      120

cttcgcgacg ccggctacct gcggctcgcc gccccgcccc atctcggcgg gcacgggctc      180

agcttcacgg attacctgga tctcttgcgc cgattcgcgc acacgcacgg gtccatccgc      240

gtgatggtgc acgtggcgaa cagcctatgg cgctcgctcg cgcagaaggc gacgccggag      300

caggtggagc ggtttgtgaa gccgtttgtc gcgggcgaca tccgcgtgac gttcacactg      360

acggagccga attcgggctc cggcgcggac atcaagacga cggcccggcg cgagggcgac      420

gagtacgtcc tgaacggcga aaagtggatg atcatcttca gcgacgtggc ggactacttc      480

ctgctcttct gccggttgga ggggacgtcg ggcggcgaag ggacgctcgc gctcctcgtc      540

ccgcgcgacg cgccgggcct cacggttgag ctcatggcgc cggccatggg catcgcgggc      600

acggcgcacg ggcaccttcg cctgcgcgac tgccgcgtac ccgtcgccaa ccgcctcggc      660

gaggagggcg acggcctgga ggtggcgttc cgcggctttc tggatccgtc ccgcaccgcc      720

attggcatga cctgcgtcgg cgcagcggag cgagcgctcg aactcgcggc cgatcacgcc      780

ctccggcgcg tcaccttcgg ccagccgctc gccaagcgcc aaatcatcca gatgtggctc      840

gcggagatgg cgacggacat cgaggcggcg cgccagctcg tcctccacgc ggcccggcgg      900

ttcgacgaag gccatcccat caccgtggag gcggcgatgg cgaagatgtt cgcgacggag      960

atgctgcagc gcgtgacgga caaggccctg cagattcacg gcgggccggg ttacttcaag     1020

tcgagcgaga tcgagcggat ctaccgggac gccaggatgc agcggttcga ggaaggcacg     1080

tcggagattc agaagatggt cattgcgcgc gacgtgatcg acaaggccaa gcgggcctca     1140

gaagggagcg agcggagatg ctggtga                                         1167


<210>   700
<211>   366
<212>   PRT
<213>   Acidothermus cellulolyticus 11B

<400>   700
Arg Arg Glu Val Glu Glu Phe Val Arg Gly Pro Gly Glu Arg Tyr Ala 
                5                   10                  15      

Glu Gln Ile Glu Ala Glu Asn Arg Val Pro Glu Ser Leu Trp Thr Glu 
            20                  25                  30          

Leu Arg Asp Arg Gly Tyr Leu Arg Leu Ala Ala Pro Gln Glu Tyr Gly 
        35                  40                  45              

Gly Arg Gly Leu Gln Phe Ser Lys Tyr Leu Glu Leu Val Glu Leu Phe 
    50                  55                  60                  

Ala Met Ser His Ala Ser Leu Arg Met Ile Val His Val Val Asn Gly 
65                  70                  75                  80  

Ile Trp Arg Ala Ile Asp Gln Leu Ala Thr Asp Glu Gln Arg Lys Lys 
                85                  90                  95      

Phe Val Leu Pro Gln Val Ala Gly Asp Ile Arg Val Ala Phe Thr Leu 
            100                 105                 110         

Thr Glu Pro Thr Ala Gly Thr Gly Ala Asp Ile Arg Ser Thr Val Val 
        115                 120                 125             

Arg Asp Gly Asp Thr Tyr Tyr Leu Thr Gly Glu Lys His Leu Ile Thr 
    130                 135                 140                 

Phe Gly Val Arg Cys Asp Tyr Trp Leu Leu Phe Ala Arg Val Ala Gly 
145                 150                 155                 160 

Thr Thr Gly Lys Asp Gly Thr Val Ala Leu Met Val Asp Arg His Ser 
                165                 170                 175     

Pro Asn Val Val Val Lys Glu Met Ser Pro Ser Met Gly Val Arg Gly 
            180                 185                 190         

Thr Asp His Ala His Leu Ile Phe Arg Glu Thr Pro Val Pro Val Ala 
        195                 200                 205             

Asn Arg Leu Gly Ala Glu Gly Glu Gly Leu Asp Val Ala Phe Gly Gly 
    210                 215                 220                 

Phe Leu Thr Pro Ser Arg Ile Ser Val Ala Met Thr Cys Val Gly Leu 
225                 230                 235                 240 

Ala Arg Arg Ala Gln Glu Leu Ala Val Glu Tyr Ala Lys Gln Arg Val 
                245                 250                 255     

Thr Phe Gly Lys Arg Leu Ala Asp Arg Gln Val Ile Ala Tyr Ala Leu 
            260                 265                 270         

Ala Glu Asn Ala Thr Asp Ile Glu Ala Ala Arg Gln Leu Thr Leu Tyr 
        275                 280                 285             

Ala Ala Arg Gln Trp Glu Ser Gly Ala Ala Asp Ala Leu Thr Leu Ser 
    290                 295                 300                 

Ser Met Ala Lys Leu Asn Ala Val Asp Met Leu Thr Arg Val Thr Asp 
305                 310                 315                 320 

Lys Ala Leu Gln Ile His Gly Gly Ile Gly Tyr Phe Gln Ser Ser Pro 
                325                 330                 335     

Ile Glu Arg Val Tyr Arg Asp Ala Arg Ala Gln Arg Phe Glu Glu Gly 
            340                 345                 350         

Thr Asn Glu Ile Gln Lys Thr Val Ile Ala Arg Ser Val Leu 
        355                 360                 365     

<210>   701
<211>   375
<212>   PRT
<213>   Streptomyces sp. HK803

<400>   701
Val Glu Arg Trp Val Glu Gly Pro Gly Glu Arg Trp Ala Glu Arg Ile 
                5                   10                  15      

Glu Glu Thr Gly Glu Val Pro Glu Ala Val Trp Ser Glu Leu Asp Glu 
            20                  25                  30          

Leu Gly Phe Leu Arg Leu Ala Ala Pro Val Glu Tyr Gly Gly Gln Gly 
        35                  40                  45              

Leu Gly Phe Thr Gln Trp Met Glu Leu Met Glu Ile Phe Ser Arg Ser 
    50                  55                  60                  

His Gly Ser Leu Arg Met Ile Val His Val Val Asn Gly Ile Trp Arg 
65                  70                  75                  80  

Ser Met Asp Gly His Ala Cys Asp Glu Gln Arg Lys Arg Phe Val Val 
                85                  90                  95      

Pro Ser Val Leu Gly Glu Ile Lys Ile Ala Phe Ala Leu Thr Glu Pro 
            100                 105                 110         

Gly Asn Gly Thr Gly Ala Asp Ile Thr Thr Ser Val Val Arg Glu Gly 
        115                 120                 125             

Asp Thr Tyr Tyr Leu Ser Gly Arg Lys His Leu Ile Thr Phe Gly Met 
    130                 135                 140                 

Arg Cys Asp Tyr Tyr Leu Leu Ala Ala Arg Val Ala Gly Ser Ala Gly 
145                 150                 155                 160 

His Glu Gly Thr Val Ala Leu Leu Val Pro Arg Asn Ala Pro Gly Val 
                165                 170                 175     

Ser Ala Glu Asp Thr Ser Arg Thr Met Gly Val Thr Gly Thr Asp His 
            180                 185                 190         

Ala Ser Ile Val Phe Asp Arg Thr Pro Val Pro Val Asp His Arg Leu 
        195                 200                 205             

Gly Glu Glu Gly Gln Gly Leu Glu Val Phe Leu Gly Gly Phe Leu Thr 
    210                 215                 220                 

Pro Ser Arg Ile Ser Val Ala Met Ser Cys Val Gly Leu Ala Gln Arg 
225                 230                 235                 240 

Ala Gln Gln Leu Ala Val Asp Tyr Ala Arg Ser Arg Val Thr Phe Gly 
                245                 250                 255     

Lys Ser Leu Thr Glu Arg Gln Ala Ile Gln Phe Met Leu Ala Glu Asn 
            260                 265                 270         

Ala Ala Asp Ile Glu Ala Ala Arg Gln Leu Val Leu His Ala Ala Arg 
        275                 280                 285             

Arg Phe Glu Glu Gly Ala Asp Asp Ala Ser Met Gln Ser Ser Met Ala 
    290                 295                 300                 

Lys Met His Ala Val Thr Met Leu Thr Thr Val Thr Asp Lys Ala Leu 
305                 310                 315                 320 

Gln Val His Gly Gly Leu Gly Tyr Trp Lys Ser Gln Lys Ile Glu Arg 
                325                 330                 335     

Val Tyr Arg Asp Ala Arg Ala Gln Arg Phe Glu Glu Gly Pro Asn Glu 
            340                 345                 350         

Val Gln Lys Ala Val Val Phe Arg Glu Leu Leu Arg Gln Ala Gly Thr 
        355                 360                 365             

Val Thr Ala Gly Gly Ala Arg 
    370                 375 

<210>   702
<211>   346
<212>   PRT
<213>   Rhodococcus sp. RHA1

<400>   702
Gln Arg Ile Glu Asp Asp Glu Gln Val Pro His Asp Ile Val Met Pro 
                5                   10                  15      

Ile Leu Glu Arg Ile Gly Ala Leu Gly Leu Leu Val Pro Arg Glu Tyr 
            20                  25                  30          

Gly Gly Ser Gly Leu Ser Ile Ala Gln Tyr Leu Pro Ile Ile Ala Glu 
        35                  40                  45              

Phe Ala Lys Val Gln Gly Ala Leu Arg Val Ile Val His Val His Asn 
    50                  55                  60                  

Ser Phe Ala His Ala Leu Ser Glu Ile Gly Ser Asp Arg Gln Lys Ala 
65                  70                  75                  80  

Asp Val Leu Pro Gly Thr Ala Thr Gly Arg Asn Ser Val Ala Phe Ala 
                85                  90                  95      

Leu Thr Glu Pro Gly Phe Gly Thr Gly Ala Asp Leu Gly Ser Thr Ala 
            100                 105                 110         

Val Arg Glu Gly Asp Gly Tyr Ile Leu Asn Gly Glu Lys Trp Leu Ile 
        115                 120                 125             

Thr Asn Ser Asp Ile Ala Ser His Phe Ile Val Phe Ala Lys Thr Thr 
    130                 135                 140                 

Ala Thr Asp Val Ser Ala Phe Leu Val Pro Arg Glu Thr Asp Gly Leu 
145                 150                 155                 160 

Ser Ile Ala Ala Leu Pro Glu Thr Met Gly Cys Lys Gly Thr Glu His 
                165                 170                 175     

Gly Arg Val Thr Leu Asp Ser Val Arg Val Pro Ala Thr Ala Leu Val 
            180                 185                 190         

Gly Val Glu Gly Gln Gly Asn Glu His Leu Glu Arg Ala Leu Glu Ile 
        195                 200                 205             

Ser Arg Val Phe Ile Ala Ala Ser Ser Leu Gly Thr Ser Glu Arg Ala 
    210                 215                 220                 

Leu Glu Leu Ser Ile Ala His Ala Lys Ser Arg Val Thr Phe Gly Lys 
225                 230                 235                 240 

Pro Ile Gly Thr Arg Gln Ala Ile Gln Arg Tyr Leu Ala Glu Met Ala 
                245                 250                 255     

Thr Asp Val Tyr Ala Leu Arg Gly Ile Leu Ala Asp Ala Ala Gln Lys 
            260                 265                 270         

Trp Asp Ala Gly Glu Arg Ile Pro Ala Glu Ala Ser Met Cys Lys Leu 
        275                 280                 285             

Phe Gly Leu Glu Ala Val Gly Arg Val Thr Asp Arg Ala Leu Leu Ile 
    290                 295                 300                 

His Gly Gly Ile Gly Tyr Thr Arg Ala His Pro Ile Glu Arg Leu Tyr 
305                 310                 315                 320 

Arg Asp Ala Arg Leu Asn Trp Leu Glu Glu Gly Thr Pro Thr Ile Gln 
                325                 330                 335     

Tyr Leu Val Thr Ala Gly Arg Leu Leu Asp 
            340                 345     

<210>   703
<211>   345
<212>   PRT
<213>   Mycobacterium smegmatis str. MC2 155

<400>   703
Glu Arg Ile Glu Asn Glu Glu Arg Ile Pro Asn Glu Ile Val Leu Pro 
                5                   10                  15      

Ile Leu Glu Arg Ile Gly Ala Phe Gly Leu Leu Val Pro Arg Glu Tyr 
            20                  25                  30          

Gly Gly Ser Gly Leu Ser Ile Ala Gln Tyr Leu Pro Ile Ile Ser Glu 
        35                  40                  45              

Phe Ala Lys Val Gln Gly Gly Leu Arg Val Ile Val His Val His Asn 
    50                  55                  60                  

Ser Phe Ala His Ala Leu Ser Glu Ile Gly Asn Asp Glu Gln Lys Ala 
65                  70                  75                  80  

Ala Val Leu His Gly Ala Ala Thr Gly Ala Asn Ser Val Ala Phe Ala 
                85                  90                  95      

Leu Thr Glu Pro Gly His Gly Thr Gly Ala Asp Leu Gly Ser Ser Ala 
            100                 105                 110         

Val Arg Met Gly Asp Glu Tyr Glu Ile Thr Gly Glu Lys Trp Leu Ile 
        115                 120                 125             

Thr Asn Ser Asp Ile Ala Thr His Phe Ile Val Phe Ala Lys Thr Ala 
    130                 135                 140                 

Pro Thr Glu Val Ser Ala Phe Leu Val Pro Arg Asp Thr Asp Gly Leu 
145                 150                 155                 160 

Ser Ile Glu Pro Leu Pro Glu Thr Met Gly Cys Lys Gly Gly Glu His 
                165                 170                 175     

Gly His Ile Arg Leu Ala Gly Val Arg Val Pro Ala Thr Ala Leu Ile 
            180                 185                 190         

Gly Ala Glu Gly Glu Gly Asn Gln His Leu Glu Arg Ala Leu Glu Ile 
        195                 200                 205             

Ser Arg Val Phe Ile Ala Ala Ser Ser Leu Gly Thr Ser Glu Arg Ala 
    210                 215                 220                 

Leu Glu Leu Ser Val Ala Arg Ala Lys Glu Arg Val Thr Phe Gly Lys 
225                 230                 235                 240 

Pro Ile Gly Ser Arg Gln Ala Ile Gln Arg Tyr Leu Ala Glu Met Ala 
                245                 250                 255     

Thr Asp Ile Tyr Ala Leu Arg Gly Leu Leu Ala Asp Ala Ala His Lys 
            260                 265                 270         

Trp Asp Ser Gly Lys Arg Ile Pro Ala Glu Ala Ser Met Cys Lys Leu 
        275                 280                 285             

Phe Gly Leu Glu Ala Val Gly Arg Val Thr Asp Arg Ala Leu Leu Ile 
    290                 295                 300                 

His Gly Gly Ile Gly Tyr Thr Arg Ala Tyr Pro Val Glu Arg Leu Tyr 
305                 310                 315                 320 

Arg Asp Ala Arg Leu Asn Trp Leu Glu Glu Gly Thr Pro Thr Ile Gln 
                325                 330                 335     

Tyr Met Val Ala Ala Asn Glu Leu Leu 
            340                 345 

<210>   704
<211>   363
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   704
Val Arg Gln Phe Ala Ala Glu Arg Val Ala Pro Phe Val Glu Glu Met 
                5                   10                  15      

Glu Met Asn Glu Thr Phe Pro Asp Ala Leu Leu Arg Glu Met Gly Glu 
            20                  25                  30          

Leu Gly Leu Leu Gly Ile Pro Val Glu Glu Glu His Gly Gly Ala Gly 
        35                  40                  45              

Met Asp Phe Thr Ser Tyr Ile Ile Ala Ile His Glu Leu Ser Lys Val 
    50                  55                  60                  

Ser Ala Thr Leu Gly Val Ile Leu Ser Val His Thr Ser Val Gly Thr 
65                  70                  75                  80  

Asn Pro Ile Arg Tyr Tyr Gly Thr Ala Asp Gln Ile Ser Arg Tyr Val 
                85                  90                  95      

Pro Lys Leu Ala Ser Gly Glu Trp Leu Gly Ala Phe Ala Leu Ser Glu 
            100                 105                 110         

Pro Gly Ala Gly Ser Asp Ala Ala Ser Leu Arg Thr Thr Ala Lys Lys 
        115                 120                 125             

Asp Gly Asp His Tyr Ile Leu Asn Gly Ser Lys Ala Trp Ile Thr Asn 
    130                 135                 140                 

Gly Gly Tyr Ala Asp Thr Tyr Ile Val Phe Ala Lys Thr Asp Pro Asp 
145                 150                 155                 160 

Ala Gly Lys Lys Gly Ile Thr Ala Phe Ile Val Glu Lys Asp Thr Pro 
                165                 170                 175     

Gly Phe Thr Val Leu Ala Lys Glu Arg Lys Met Gly Leu Leu Gly Ser 
            180                 185                 190         

Ser Thr Thr Gly Leu Ala Phe Glu Asp Cys Arg Ile His Glu Ser Arg 
        195                 200                 205             

Arg Leu Gly Glu Glu Gly Gln Gly Tyr Thr Ile Ala Leu Ser Asn Leu 
    210                 215                 220                 

Asp Tyr Gly Arg Val Gly Ile Ala Ala Gln Ala Leu Gly Ile Ala Glu 
225                 230                 235                 240 

Ala Ala Leu Glu His Ala Thr Asp Tyr Ala Lys Glu Arg Lys Gln Phe 
                245                 250                 255     

Gly Lys Pro Ile Ala Met Gln Gln Gly Leu Ala Phe Lys Leu Ala Asp 
            260                 265                 270         

Met Ala Thr Ala Val Glu Ala Ala Lys Leu Leu Thr Tyr Ser Ala Ala 
        275                 280                 285             

Asn Arg Lys Asp Gln Gly Leu Thr Thr Gly Ile Glu Ala Ser Met Ala 
    290                 295                 300                 

Lys Thr Phe Ala Ser Asp Thr Ala Met Lys Val Thr Thr Glu Ala Ile 
305                 310                 315                 320 

Gln Val Phe Gly Gly Tyr Gly Tyr Thr Lys Asp Tyr Pro Val Glu Arg 
                325                 330                 335     

Phe Phe Arg Asp Ala Lys Val Thr Gln Ile Tyr Glu Gly Thr Asn Glu 
            340                 345                 350         

Ile Gln Arg Ile Val Ile Ala Gly Gln Leu Leu 
        355                 360             

<210>   705
<211>   388
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   705
Met Met Arg Thr Leu Asp Glu Trp Lys Lys Asp Val Asp Ala Tyr Val 
                5                   10                  15      

Ala Gly Pro Ala Arg Ala Trp Ser Glu His Ile Glu Ala Thr Gly Thr 
            20                  25                  30          

Val Pro Asp Ala Leu Trp Arg Glu Leu Arg Asp Ala Gly Tyr Leu Arg 
        35                  40                  45              

Leu Ala Ala Pro Pro His Leu Gly Gly His Gly Leu Ser Phe Thr Asp 
    50                  55                  60                  

Tyr Leu Asp Leu Leu Arg Arg Phe Ala His Thr His Gly Ser Ile Arg 
65                  70                  75                  80  

Val Met Val His Val Ala Asn Ser Leu Trp Arg Ser Leu Ala Gln Lys 
                85                  90                  95      

Ala Thr Pro Glu Gln Val Glu Arg Phe Val Lys Pro Phe Val Ala Gly 
            100                 105                 110         

Asp Ile Arg Val Thr Phe Thr Leu Thr Glu Pro Asn Ser Gly Ser Gly 
        115                 120                 125             

Ala Asp Ile Lys Thr Thr Ala Arg Arg Glu Gly Asp Glu Tyr Val Leu 
    130                 135                 140                 

Asn Gly Glu Lys Trp Met Ile Ile Phe Ser Asp Val Ala Asp Tyr Phe 
145                 150                 155                 160 

Leu Leu Phe Cys Arg Leu Glu Gly Thr Ser Gly Gly Glu Gly Thr Ile 
                165                 170                 175     

Ala Leu Leu Val Pro Arg Asp Ala Pro Gly Leu Thr Val Glu Leu Met 
            180                 185                 190         

Ala Pro Ala Met Gly Ile Ala Gly Thr Ala His Gly His Leu Arg Leu 
        195                 200                 205             

Arg Asp Cys Arg Val Pro Val Ala Asn Arg Leu Gly Glu Glu Gly Asp 
    210                 215                 220                 

Gly Leu Glu Val Ala Phe Arg Gly Phe Leu Asp Pro Ser Arg Thr Ala 
225                 230                 235                 240 

Ile Gly Met Thr Cys Val Gly Ala Ala Glu Arg Ala Leu Glu Leu Ala 
                245                 250                 255     

Ala Asp His Ala Leu Arg Arg Val Thr Phe Gly Gln Pro Leu Ala Lys 
            260                 265                 270         

Arg Gln Ile Ile Gln Met Trp Leu Ala Glu Met Ala Thr Asp Ile Glu 
        275                 280                 285             

Ala Ala Arg Gln Leu Val Leu His Ala Ala Arg Arg Phe Asp Glu Gly 
    290                 295                 300                 

His Pro Ile Thr Val Glu Ala Ala Met Ala Lys Met Phe Ala Thr Glu 
305                 310                 315                 320 

Met Leu Gln Arg Val Thr Asp Lys Ala Leu Gln Ile His Gly Gly Pro 
                325                 330                 335     

Gly Tyr Phe Lys Ser Ser Glu Ile Glu Arg Ile Tyr Arg Asp Ala Arg 
            340                 345                 350         

Met Gln Arg Phe Glu Glu Gly Thr Ser Glu Ile Gln Lys Met Val Ile 
        355                 360                 365             

Ala Arg Asp Val Ile Asp Lys Ala Lys Arg Ala Ser Glu Gly Ser Glu 
    370                 375                 380                 

Arg Arg Cys Trp 
385             

<210>   706
<211>   388
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   706
Met Met Arg Thr Leu Asp Glu Trp Lys Lys Asp Val Asp Ala Tyr Val 
                5                   10                  15      

Ala Gly Pro Ala Arg Ala Trp Ser Glu His Ile Glu Ala Thr Gly Thr 
            20                  25                  30          

Val Pro Asp Ala Leu Trp Arg Glu Leu Arg Asp Ala Gly Tyr Leu Arg 
        35                  40                  45              

Leu Ala Ala Pro Pro His Leu Gly Gly His Gly Leu Ser Phe Thr Asp 
    50                  55                  60                  

Tyr Leu Asp Leu Leu Arg Arg Phe Ala His Thr His Gly Ser Ile Arg 
65                  70                  75                  80  

Val Met Val His Val Ala Asn Ser Leu Trp Arg Ser Leu Ala Gln Lys 
                85                  90                  95      

Ala Thr Pro Glu Gln Val Glu Arg Phe Val Lys Pro Phe Val Ala Gly 
            100                 105                 110         

Asp Ile Arg Val Thr Phe Thr Leu Thr Glu Pro Asn Ser Gly Ser Gly 
        115                 120                 125             

Ala Asp Ile Lys Thr Thr Ala Arg Arg Glu Gly Asp Glu Tyr Val Leu 
    130                 135                 140                 

Asn Gly Glu Lys Trp Met Ile Ile Phe Ser Asp Val Ala Asp Tyr Phe 
145                 150                 155                 160 

Leu Leu Phe Cys Arg Ile Glu Gly Thr Ser Gly Gly Glu Gly Thr Leu 
                165                 170                 175     

Ala Leu Leu Val Pro Arg Asp Ala Pro Gly Leu Thr Val Glu Leu Met 
            180                 185                 190         

Ala Pro Ala Met Gly Ile Ala Gly Thr Ala His Gly His Leu Arg Leu 
        195                 200                 205             

Arg Asp Cys Arg Val Pro Val Ala Asn Arg Leu Gly Glu Glu Gly Asp 
    210                 215                 220                 

Gly Leu Glu Val Ala Phe Arg Gly Phe Leu Asp Pro Ser Arg Thr Ala 
225                 230                 235                 240 

Ile Gly Met Thr Cys Val Gly Ala Ala Glu Arg Ala Leu Glu Leu Ala 
                245                 250                 255     

Ala Asp His Ala Leu Arg Arg Val Thr Phe Gly Gln Pro Leu Ala Lys 
            260                 265                 270         

Arg Gln Ile Ile Gln Met Trp Leu Ala Glu Met Ala Thr Asp Ile Glu 
        275                 280                 285             

Ala Ala Arg Gln Leu Val Leu His Ala Ala Arg Arg Phe Asp Glu Gly 
    290                 295                 300                 

His Pro Ile Thr Val Glu Ala Ala Met Ala Lys Met Phe Ala Thr Glu 
305                 310                 315                 320 

Met Leu Gln Arg Val Thr Asp Lys Ala Leu Gln Ile His Gly Gly Pro 
                325                 330                 335     

Gly Tyr Phe Lys Ser Ser Glu Ile Glu Arg Ile Tyr Arg Asp Ala Arg 
            340                 345                 350         

Met Gln Arg Phe Glu Glu Gly Thr Ser Glu Ile Gln Lys Met Val Ile 
        355                 360                 365             

Ala Arg Asp Val Ile Asp Lys Ala Lys Arg Ala Ser Glu Gly Ser Glu 
    370                 375                 380                 

Arg Arg Cys Trp 
385             

<210>   707
<211>   388
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   707
Met Met Arg Thr Leu Asp Glu Trp Lys Lys Asp Val Asp Ala Tyr Val 
                5                   10                  15      

Ala Gly Pro Ala Arg Ala Trp Ser Glu His Ile Glu Ala Thr Gly Thr 
            20                  25                  30          

Val Pro Asp Ala Leu Trp Arg Glu Leu Arg Asp Ala Gly Tyr Leu Arg 
        35                  40                  45              

Leu Ala Ala Pro Pro His Leu Gly Gly His Gly Leu Ser Phe Thr Asp 
    50                  55                  60                  

Tyr Leu Asp Leu Leu Arg Arg Phe Ala His Thr His Gly Ser Ile Arg 
65                  70                  75                  80  

Val Met Val His Val Ala Asn Ser Leu Trp Arg Ser Leu Ala Gln Lys 
                85                  90                  95      

Ala Thr Pro Glu Gln Val Glu Arg Phe Val Lys Pro Phe Val Ala Gly 
            100                 105                 110         

Asp Ile Arg Val Thr Phe Thr Leu Thr Glu Pro Asn Ser Gly Ser Gly 
        115                 120                 125             

Ala Asp Ile Lys Thr Thr Ala Arg Arg Glu Gly Asp Glu Tyr Val Leu 
    130                 135                 140                 

Asn Gly Glu Lys Trp Met Ile Ile Phe Ser Asp Val Ala Asp Tyr Phe 
145                 150                 155                 160 

Leu Leu Phe Cys Arg Leu Glu Gly Thr Ser Gly Gly Glu Gly Thr Leu 
                165                 170                 175     

Ala Leu Leu Val Pro Arg Asp Ala Pro Gly Leu Thr Val Glu Leu Met 
            180                 185                 190         

Ala Pro Ala Met Gly Ile Ala Gly Thr Ala His Gly His Leu Arg Leu 
        195                 200                 205             

Arg Asp Cys Arg Val Pro Val Ala Asn Arg Leu Gly Glu Glu Gly Asp 
    210                 215                 220                 

Gly Leu Glu Val Ala Phe Arg Gly Phe Leu Asp Pro Ser Arg Thr Ala 
225                 230                 235                 240 

Ile Gly Met Thr Cys Val Gly Ala Ala Glu Arg Ala Leu Glu Leu Ala 
                245                 250                 255     

Ala Asp His Ala Leu Arg Arg Val Thr Phe Gly Gln Pro Leu Ala Lys 
            260                 265                 270         

Arg Gln Ile Ile Gln Met Trp Leu Ala Glu Met Ala Thr Asp Ile Glu 
        275                 280                 285             

Ala Ala Arg Gln Leu Val Leu His Ala Ala Arg Arg Phe Asp Glu Gly 
    290                 295                 300                 

His Pro Ile Thr Val Glu Ala Ala Met Ala Lys Met Phe Ala Thr Glu 
305                 310                 315                 320 

Met Leu Gln Arg Val Thr Asp Lys Ala Leu Gln Ile His Gly Gly Pro 
                325                 330                 335     

Gly Tyr Phe Lys Ser Ser Glu Ile Glu Arg Ile Tyr Arg Asp Ala Arg 
            340                 345                 350         

Met Gln Arg Phe Glu Glu Gly Thr Ser Glu Ile Gln Lys Met Val Ile 
        355                 360                 365             

Ala Arg Asp Val Ile Asp Lys Ala Lys Lys Ala Ser Glu Gly Ser Glu 
    370                 375                 380                 

Arg Arg Cys Trp 
385             

<210>   708
<211>   388
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   708
Met Met Arg Thr Leu Asp Glu Trp Lys Lys Asp Val Asp Ala Tyr Val 
                5                   10                  15      

Ala Gly Pro Ala Arg Ala Trp Ser Glu His Ile Glu Ala Thr Gly Thr 
            20                  25                  30          

Val Pro Asp Ala Leu Trp Arg Glu Leu Arg Asp Ala Gly Tyr Leu Arg 
        35                  40                  45              

Leu Ala Ala Pro Pro His Leu Gly Gly His Gly Leu Ser Phe Thr Asp 
    50                  55                  60                  

Tyr Leu Asp Leu Leu Arg Arg Phe Ala His Thr His Gly Ser Ile Arg 
65                  70                  75                  80  

Val Met Val His Val Ala Asn Ser Leu Trp Arg Ser Leu Ala Gln Lys 
                85                  90                  95      

Ala Thr Pro Glu Gln Val Glu Arg Phe Val Lys Pro Phe Val Ala Gly 
            100                 105                 110         

Asp Ile Arg Val Thr Phe Thr Leu Thr Glu Pro Asn Ser Gly Ser Gly 
        115                 120                 125             

Ala Asp Ile Lys Thr Thr Ala Arg Arg Glu Gly Asp Glu Tyr Val Leu 
    130                 135                 140                 

Asn Gly Glu Lys Trp Met Ile Ile Phe Ser Asp Val Ala Asp Tyr Phe 
145                 150                 155                 160 

Leu Leu Phe Cys Arg Leu Glu Gly Thr Ser Gly Gly Glu Gly Thr Leu 
                165                 170                 175     

Ala Leu Leu Val Pro Arg Asp Ala Pro Gly Leu Thr Val Glu Leu Met 
            180                 185                 190         

Ala Pro Ala Met Gly Ile Ala Gly Thr Ala His Gly His Leu Arg Leu 
        195                 200                 205             

Arg Asp Cys Arg Val Pro Val Ala Asn Arg Leu Gly Asp Glu Gly Asp 
    210                 215                 220                 

Gly Leu Glu Val Ala Phe Arg Gly Phe Leu Asp Pro Ser Arg Thr Ala 
225                 230                 235                 240 

Ile Gly Met Thr Cys Val Gly Ala Ala Glu Arg Ala Leu Glu Leu Ala 
                245                 250                 255     

Ala Asp His Ala Leu Arg Arg Val Thr Phe Gly Gln Pro Leu Ala Lys 
            260                 265                 270         

Arg Gln Ile Ile Gln Met Trp Leu Ala Glu Met Ala Thr Asp Ile Glu 
        275                 280                 285             

Ala Ala Arg Gln Leu Val Leu His Ala Ala Arg Arg Phe Asp Glu Gly 
    290                 295                 300                 

His Pro Ile Thr Val Glu Ala Ala Met Ala Lys Met Phe Ala Thr Glu 
305                 310                 315                 320 

Met Leu Gln Arg Val Thr Asp Lys Ala Leu Gln Ile His Gly Gly Pro 
                325                 330                 335     

Gly Tyr Phe Lys Ser Ser Glu Ile Glu Arg Ile Tyr Arg Asp Ala Arg 
            340                 345                 350         

Met Gln Arg Phe Glu Glu Gly Thr Ser Glu Ile Gln Lys Met Val Ile 
        355                 360                 365             

Ala Arg Asp Val Ile Asp Lys Ala Lys Arg Ala Ser Glu Gly Ser Glu 
    370                 375                 380                 

Arg Arg Cys Trp 
385             

<210>   709
<211>   388
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   709
Met Met Arg Thr Leu Asp Glu Trp Lys Lys Asp Val Asp Ala Tyr Val 
                5                   10                  15      

Ala Gly Pro Ala Arg Ala Trp Ser Glu His Ile Glu Ala Thr Gly Thr 
            20                  25                  30          

Val Pro Asp Ala Leu Trp Arg Glu Leu Arg Asp Ala Gly Tyr Leu Arg 
        35                  40                  45              

Leu Ala Ala Pro Pro His Leu Gly Gly His Gly Leu Ser Phe Thr Asp 
    50                  55                  60                  

Tyr Leu Asp Leu Leu Arg Arg Phe Ala His Thr His Gly Ser Ile Arg 
65                  70                  75                  80  

Val Met Val His Val Ala Asn Ser Leu Trp Arg Ser Leu Ala Gln Lys 
                85                  90                  95      

Ala Thr Pro Glu Gln Val Glu Arg Phe Val Arg Pro Phe Val Ala Gly 
            100                 105                 110         

Asp Ile Arg Val Thr Phe Thr Leu Thr Glu Pro Asn Ser Gly Ser Gly 
        115                 120                 125             

Ala Asp Ile Lys Thr Thr Ala Arg Arg Glu Gly Asp Glu Tyr Val Leu 
    130                 135                 140                 

Asn Gly Glu Lys Trp Met Ile Ile Phe Ser Asp Val Ala Asp Tyr Phe 
145                 150                 155                 160 

Leu Leu Phe Cys Arg Leu Glu Gly Thr Ser Gly Gly Glu Gly Thr Leu 
                165                 170                 175     

Ala Leu Leu Val Pro Arg Asp Ala Pro Gly Leu Thr Val Glu Leu Met 
            180                 185                 190         

Ala Pro Ala Met Gly Ile Ala Gly Thr Ala His Gly His Leu Arg Leu 
        195                 200                 205             

Arg Asp Cys Arg Val Pro Val Ala Asn Arg Leu Gly Glu Glu Gly Asp 
    210                 215                 220                 

Gly Leu Glu Val Ala Phe Arg Gly Phe Leu Asp Pro Ser Arg Thr Ala 
225                 230                 235                 240 

Ile Gly Met Thr Cys Val Gly Ala Ala Glu Arg Ala Leu Glu Leu Ala 
                245                 250                 255     

Ala Asp His Ala Leu Arg Arg Val Thr Phe Gly Gln Pro Leu Ala Lys 
            260                 265                 270         

Arg Gln Ile Ile Gln Met Trp Leu Ala Glu Met Ala Thr Asp Ile Glu 
        275                 280                 285             

Ala Ala Arg Gln Leu Val Leu His Ala Ala Arg Arg Phe Asp Glu Gly 
    290                 295                 300                 

His Pro Ile Thr Val Glu Ala Ala Met Ala Lys Met Phe Ala Thr Glu 
305                 310                 315                 320 

Met Leu Gln Arg Val Thr Asp Lys Ala Leu Gln Ile His Gly Gly Pro 
                325                 330                 335     

Gly Tyr Phe Lys Ser Ser Glu Ile Glu Arg Ile Tyr Arg Asp Ala Arg 
            340                 345                 350         

Met Gln Arg Phe Glu Glu Gly Thr Ser Glu Ile Gln Lys Met Val Ile 
        355                 360                 365             

Ala Arg Asp Val Ile Asp Lys Ala Lys Arg Ala Ser Glu Gly Ser Glu 
    370                 375                 380                 

Arg Arg Cys Trp 
385             

<210>   710
<211>   1167
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   710
atgatgcgga cgctggacga gtggaagaag gacgtcgacg cttacgtcgc gggcccggcc       60

agggcgtggt ctgagcatat tgaggcgacg gggacggtgc cggacgccct gtggcgagag      120

cttcgcgacg ccggctacct gcggctcgcc gccccgcccc atctcggcgg gcacgggctc      180

agcttcacgg attacctgga tctcttgcgc cgattcgcgc acacgcacgg gtccatccgc      240

gtgatggtgc acgtggcgaa cagcctatgg cgctcgctcg cgcagaaggc gacgccggag      300

caggtggagc ggtttgtgaa gccgtttgtc gcgggcgaca tccgcgtgac gttcacactg      360

acggagccga attcgggctc cggcgcggac atcaagacga cggcccggcg cgagggcgac      420

gagtacgtcc tgaacggcga aaagtggatg atcatcttca gcgacgtggc ggactacttc      480

ctgctcttct gccggttgga ggggacgtcg ggcggcgaag ggacgattgc gctcctcgtc      540

ccgcgcgacg cgccgggcct cacggttgag ctcatggcgc cggccatggg catcgcgggc      600

acggcgcacg ggcaccttcg cctgcgcgac tgccgcgtac ccgtcgccaa ccgcctcggc      660

gaggagggcg acggcctgga ggtggcgttc cgcggctttc tggatccgtc ccgcaccgcc      720

attggcatga cctgcgtcgg cgcagcggag cgagcgctcg aactcgcggc cgatcacgcc      780

ctccggcgcg tcaccttcgg ccagccgctc gccaagcgcc aaatcatcca gatgtggctc      840

gcggagatgg cgacggacat cgaggcggcg cgccagctcg tcctccacgc ggcccggcgg      900

ttcgacgaag gccatcccat caccgtggag gcggcgatgg cgaagatgtt cgcgacggag      960

atgctgcagc gcgtgacgga caaggccctg cagattcacg gcgggccggg ttacttcaag     1020

tcgagcgaga tcgagcggat ctaccgggac gccaggatgc agcggttcga ggaaggcacg     1080

tcggagattc agaagatggt cattgcgcgc gacgtgatcg acaaggccaa gcgggcctca     1140

gaagggagcg agcggagatg ctggtga                                         1167


<210>   711
<211>   1167
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   711
atgatgcgga cgctggacga gtggaagaag gacgtcgacg cttacgtcgc gggcccggcc       60

agggcgtggt ctgagcatat tgaggcgacg gggacggtgc cggacgccct gtggcgagag      120

cttcgcgacg ccggctacct gcggctcgcc gccccgcccc atctcggcgg gcacgggctc      180

agcttcacgg attacctgga tctcttgcgc cgattcgcgc acacgcacgg gtccatccgc      240

gtgatggtgc acgtggcgaa cagcctatgg cgctcgctcg cgcagaaggc gacgccggag      300

caggtggagc ggtttgtgaa gccgtttgtc gcgggcgaca tccgcgtgac gttcacactg      360

acggagccga attcgggctc cggcgcggac atcaagacga cggcccggcg cgagggcgac      420

gagtacgtcc tgaacggcga aaagtggatg atcatcttca gcgacgtggc ggactacttc      480

ctgctcttct gccggattga ggggacgtcg ggcggcgaag ggacgctcgc gctcctcgtc      540

ccgcgcgacg cgccgggcct cacggttgag ctcatggcgc cggccatggg catcgcgggc      600

acggcgcacg ggcaccttcg cctgcgcgac tgccgcgtac ccgtcgccaa ccgcctcggc      660

gaggagggcg acggcctgga ggtggcgttc cgcggctttc tggatccgtc ccgcaccgcc      720

attggcatga cctgcgtcgg cgcagcggag cgagcgctcg aactcgcggc cgatcacgcc      780

ctccggcgcg tcaccttcgg ccagccgctc gccaagcgcc aaatcatcca gatgtggctc      840

gcggagatgg cgacggacat cgaggcggcg cgccagctcg tcctccacgc ggcccggcgg      900

ttcgacgaag gccatcccat caccgtggag gcggcgatgg cgaagatgtt cgcgacggag      960

atgctgcagc gcgtgacgga caaggccctg cagattcacg gcgggccggg ttacttcaag     1020

tcgagcgaga tcgagcggat ctaccgggac gccaggatgc agcggttcga ggaaggcacg     1080

tcggagattc agaagatggt cattgcgcgc gacgtgatcg acaaggccaa gcgggcctca     1140

gaagggagcg agcggagatg ctggtga                                         1167


<210>   712
<211>   1167
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   712
atgatgcgga cgctggacga gtggaagaag gacgtcgacg cttacgtcgc gggcccggcc       60

agggcgtggt ctgagcatat tgaggcgacg gggacggtgc cggacgccct gtggcgagag      120

cttcgcgacg ccggctacct gcggctcgcc gccccgcccc atctcggcgg gcacgggctc      180

agcttcacgg attacctgga tctcttgcgc cgattcgcgc acacgcacgg gtccatccgc      240

gtgatggtgc acgtggcgaa cagcctatgg cgctcgctcg cgcagaaggc gacgccggag      300

caggtggagc ggtttgtgaa gccgtttgtc gcgggcgaca tccgcgtgac gttcacactg      360

acggagccga attcgggctc cggcgcggac atcaagacga cggcccggcg cgagggcgac      420

gagtacgtcc tgaacggcga aaagtggatg atcatcttca gcgacgtggc ggactacttc      480

ctgctcttct gccggttgga ggggacgtcg ggcggcgaag ggacgctcgc gctcctcgtc      540

ccgcgcgacg cgccgggcct cacggttgag ctcatggcgc cggccatggg catcgcgggc      600

acggcgcacg ggcaccttcg cctgcgcgac tgccgcgtac ccgtcgccaa ccgcctcggc      660

gaggagggcg acggcctgga ggtggcgttc cgcggctttc tggatccgtc ccgcaccgcc      720

attggcatga cctgcgtcgg cgcagcggag cgagcgctcg aactcgcggc cgatcacgcc      780

ctccggcgcg tcaccttcgg ccagccgctc gccaagcgcc aaatcatcca gatgtggctc      840

gcggagatgg cgacggacat cgaggcggcg cgccagctcg tcctccacgc ggcccggcgg      900

ttcgacgaag gccatcccat caccgtggag gcggcgatgg cgaagatgtt cgcgacggag      960

atgctgcagc gcgtgacgga caaggccctg cagattcacg gcgggccggg ttacttcaag     1020

tcgagcgaga tcgagcggat ctaccgggac gccaggatgc agcggttcga ggaaggcacg     1080

tcggagattc agaagatggt cattgcgcgc gacgtgatcg acaaggccaa gaaagcctca     1140

gaagggagcg agcggagatg ctggtga                                         1167


<210>   713
<211>   1167
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   713
atgatgcgga cgctggacga gtggaagaag gacgtcgacg cttacgtcgc gggcccggcc       60

agggcgtggt ctgagcatat tgaggcgacg gggacggtgc cggacgccct gtggcgagag      120

cttcgcgacg ccggctacct gcggctcgcc gccccgcccc atctcggcgg gcacgggctc      180

agcttcacgg attacctgga tctcttgcgc cgattcgcgc acacgcacgg gtccatccgc      240

gtgatggtgc acgtggcgaa cagcctatgg cgctcgctcg cgcagaaggc gacgccggag      300

caggtggagc ggtttgtgaa gccgtttgtc gcgggcgaca tccgcgtgac gttcacactg      360

acggagccga attcgggctc cggcgcggac atcaagacga cggcccggcg cgagggcgac      420

gagtacgtcc tgaacggcga aaagtggatg atcatcttca gcgacgtggc ggactacttc      480

ctgctcttct gccggttgga ggggacgtcg ggcggcgaag ggacgctcgc gctcctcgtc      540

ccgcgcgacg cgccgggcct cacggttgag ctcatggcgc cggccatggg catcgcgggc      600

acggcgcacg ggcaccttcg cctgcgcgac tgccgcgtac ccgtcgccaa ccgcctcggc      660

gatgagggcg acggcctgga ggtggcgttc cgcggctttc tggatccgtc ccgcaccgcc      720

attggcatga cctgcgtcgg cgcagcggag cgagcgctcg aactcgcggc cgatcacgcc      780

ctccggcgcg tcaccttcgg ccagccgctc gccaagcgcc aaatcatcca gatgtggctc      840

gcggagatgg cgacggacat cgaggcggcg cgccagctcg tcctccacgc ggcccggcgg      900

ttcgacgaag gccatcccat caccgtggag gcggcgatgg cgaagatgtt cgcgacggag      960

atgctgcagc gcgtgacgga caaggccctg cagattcacg gcgggccggg ttacttcaag     1020

tcgagcgaga tcgagcggat ctaccgggac gccaggatgc agcggttcga ggaaggcacg     1080

tcggagattc agaagatggt cattgcgcgc gacgtgatcg acaaggccaa gcgggcctca     1140

gaagggagcg agcggagatg ctggtga                                         1167


<210>   714
<211>   1167
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   714
atgatgcgga cgctggacga gtggaagaag gacgtcgacg cttacgtcgc gggcccggcc       60

agggcgtggt ctgagcatat tgaggcgacg gggacggtgc cggacgccct gtggcgagag      120

cttcgcgacg ccggctacct gcggctcgcc gccccgcccc atctcggcgg gcacgggctc      180

agcttcacgg attacctgga tctcttgcgc cgattcgcgc acacgcacgg gtccatccgc      240

gtgatggtgc acgtggcgaa cagcctatgg cgctcgctcg cgcagaaggc gacgccggag      300

caggtggagc ggtttgtgcg tccgtttgtc gcgggcgaca tccgcgtgac gttcacactg      360

acggagccga attcgggctc cggcgcggac atcaagacga cggcccggcg cgagggcgac      420

gagtacgtcc tgaacggcga aaagtggatg atcatcttca gcgacgtggc ggactacttc      480

ctgctcttct gccggttgga ggggacgtcg ggcggcgaag ggacgctcgc gctcctcgtc      540

ccgcgcgacg cgccgggcct cacggttgag ctcatggcgc cggccatggg catcgcgggc      600

acggcgcacg ggcaccttcg cctgcgcgac tgccgcgtac ccgtcgccaa ccgcctcggc      660

gaggagggcg acggcctgga ggtggcgttc cgcggctttc tggatccgtc ccgcaccgcc      720

attggcatga cctgcgtcgg cgcagcggag cgagcgctcg aactcgcggc cgatcacgcc      780

ctccggcgcg tcaccttcgg ccagccgctc gccaagcgcc aaatcatcca gatgtggctc      840

gcggagatgg cgacggacat cgaggcggcg cgccagctcg tcctccacgc ggcccggcgg      900

ttcgacgaag gccatcccat caccgtggag gcggcgatgg cgaagatgtt cgcgacggag      960

atgctgcagc gcgtgacgga caaggccctg cagattcacg gcgggccggg ttacttcaag     1020

tcgagcgaga tcgagcggat ctaccgggac gccaggatgc agcggttcga ggaaggcacg     1080

tcggagattc agaagatggt cattgcgcgc gacgtgatcg acaaggccaa gcgggcctca     1140

gaagggagcg agcggagatg ctggtga                                         1167


<210>   715
<211>   393
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   715
Met Glu Val Ser Arg Val Asp Phe Thr Leu Pro Ser Glu Leu Glu Glu 
                5                   10                  15      

Met Arg Arg Thr Ile Arg Asp Phe Val Glu His Glu Val Glu Pro Leu 
            20                  25                  30          

Ala Met Gln Ile Glu Glu Glu Asp Arg Val Pro Asp Ser Val Leu Glu 
        35                  40                  45              

Lys Ser Lys Glu Leu Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr 
    50                  55                  60                  

Gly Gly Ile Gly Leu Ser Met Leu Gly Lys Cys Val Ile Tyr Glu Glu 
65                  70                  75                  80  

Leu Gly Lys Thr Ile Asn Gly Tyr Thr Thr Ile Ile Gly Ala His Asn 
                85                  90                  95      

Gly Ile Gly Ser Val Gly Ile Val Glu Phe Gly Thr Lys Glu Gln Lys 
            100                 105                 110         

Glu Lys Tyr Leu Pro Lys Met Ala Thr Gly Glu Trp Ile Gly Ala Phe 
        115                 120                 125             

Ala Leu Thr Glu Pro Gln Ala Gly Ser Asn Ala Ala Ala Ile Lys Thr 
    130                 135                 140                 

Thr Ala Val Lys Lys Gly Asp Arg Tyr Ile Leu Asn Gly Gln Lys Ile 
145                 150                 155                 160 

Tyr Ile Thr Asn Ala Pro Tyr Ala His Val Phe Thr Val Met Ala Val 
                165                 170                 175     

Thr Asp Pro Ser Lys Gly Ala Lys Gly Ile Thr Ser Phe Ile Val Glu 
            180                 185                 190         

Arg Asp Phe Pro Gly Phe Arg Val Gly His Ile Glu Lys Lys Met Gly 
        195                 200                 205             

Leu His Gly Ser His Thr Ala Gln Ile Phe Phe Glu Asp Met Glu Val 
    210                 215                 220                 

Pro Glu Glu Asn Val Leu Gly Arg Glu Gly Glu Gly Tyr Val Asn Ala 
225                 230                 235                 240 

Leu Lys Ile Leu Ala Asn Gly Arg Ala Gly Leu Ala Ala Arg Cys Leu 
                245                 250                 255     

Gly Ser Cys Glu Tyr Leu Leu Asp Lys Ser Leu Ala Phe Ala His Glu 
            260                 265                 270         

Arg Ile Gln Phe Gly Lys Pro Ile Phe Glu Gln Gln Ile Ile Gln His 
        275                 280                 285             

Tyr Leu Ala Glu Met Ala Leu Glu Ile Glu Leu Leu Arg Thr Phe Val 
    290                 295                 300                 

Tyr Arg Val Ala Trp Met Thr Asp Gln Lys Met Asn Val Ile Lys Glu 
305                 310                 315                 320 

Ala Ala Met Leu Lys Leu Tyr Gly Ser Glu Val Tyr Asn Arg Val Ala 
                325                 330                 335     

Asp Lys Ala Val Gln Ile His Gly Gly Leu Gly Phe Ile Ala Glu Tyr 
            340                 345                 350         

Pro Ile Glu Arg Phe Tyr Arg Asp Ala Arg Ile Thr Arg Ile Tyr Glu 
        355                 360                 365             

Gly Thr Ser Glu Ile Gln Lys Asn Ile Ile Ala Ala Gln Leu His Lys 
    370                 375                 380                 

Glu Tyr Glu Arg Thr Lys Ala Asp Ala 
385                 390             

<210>   716
<211>   1182
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   716
gtggaggtga gtcgcgtgga ctttacgctc ccatccgagc tggaagagat gaggcggacc       60

attcgcgact ttgtggaaca cgaggttgaa ccgctcgcca tgcagattga ggaagaggat      120

cgcgtgccgg acagcgtgct ggaaaaatcg aaggagcttg gactgtttgg cctcagcatc      180

cccgaggagt acggtggcat cggcctcagc atgctgggca agtgcgtcat ctacgaggag      240

ctcggcaaga ccatcaacgg ctacacgacc atcatcggcg cgcacaacgg cattggttcg      300

gtcggcatcg tggagtttgg caccaaggag cagaaggaga aatacctgcc caagatggcg      360

acgggtgagt ggatcggcgc gtttgcgctc accgagccgc aggccggatc gaacgcggcg      420

gccattaaga cgacggcggt aaagaagggc gataggtaca tcctcaacgg ccagaagatc      480

tacatcacaa acgcgccgta tgcgcacgtg ttcacggtga tggcggtcac ggatccgtcc      540

aaaggggcga agggcatcac ctcgttcatc gtcgaacgcg actttccagg ttttcgtgtg      600

ggacacattg aaaagaagat ggggctgcat ggatcacaca cggcgcagat cttcttcgag      660

gacatggagg ttccggagga gaacgtcctg ggccgagagg gcgaaggata tgtcaacgcg      720

ctcaagattc tggccaacgg ccgagcaggg ctcgcggcga ggtgcctggg ttcctgtgaa      780

tatctgctgg acaaatcgct ggcgtttgcg cacgagcgca tccagttcgg caagcccatc      840

tttgaacagc agatcatcca gcactacctc gcggagatgg cgctcgagat cgaactgctg      900

cgcacctttg tctaccgcgt ggcgtggatg acggatcaga aaatgaacgt catcaaggaa      960

gctgcgatgc tgaagctata cgggtccgag gtctacaacc gcgtggcgga caaggcggtc     1020

cagatccacg gcgggctcgg tttcatcgcg gagtatccca tcgagcggtt ctatcgcgat     1080

gcgcgcatca cgaggatcta cgagggaacg tccgagatcc aaaagaacat cattgccgca     1140

cagctgcaca aggagtacga gcgcaccaag gcggatgcgt ga                        1182


<210>   717
<211>   386
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   717
Met Asp Phe Thr Leu Pro Ala Glu Ile Glu Phe Leu Lys Glu Asn Val 
                5                   10                  15      

Arg Lys Phe Val Arg Glu Val Val Glu Pro Val Ala Met Asp Ile Glu 
            20                  25                  30          

Glu Asn Asp Gln Ile Pro Gln Asp Ile Ile Glu Lys Ser Lys Glu Met 
        35                  40                  45              

Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr Gly Gly Leu Gly Leu 
    50                  55                  60                  

Ser Met Val Gly Lys Cys Ala Ile Tyr Glu Glu Leu Gly Lys Thr His 
65                  70                  75                  80  

Asn Gly Tyr Thr Thr Leu Ile Gly Ala His Thr Gly Ile Gly Thr Val 
                85                  90                  95      

Gly Ile Val Glu Leu Gly Thr Glu Glu Gln Lys Gln Arg Tyr Leu Pro 
            100                 105                 110         

Lys Met Ala Thr Gly Glu Trp Ile Gly Ala Phe Ala Leu Thr Glu Pro 
        115                 120                 125             

Ser Ala Gly Ser Asn Ala Ala Ala Ile Lys Thr Thr Ala Val Arg Lys 
    130                 135                 140                 

Gly Asp Arg Tyr Ile Ile Asn Gly Ser Lys His Tyr Ile Thr Asn Ala 
145                 150                 155                 160 

Val Asp Ala His Val Phe Thr Val Met Ala Val Thr Asp Pro Ser Lys 
                165                 170                 175     

Gly Pro Lys Gly Ile Thr Ser Phe Ile Val Glu Lys Asp Phe Pro Gly 
            180                 185                 190         

Phe Ile Val Gly Lys Val Glu Arg Lys Met Gly Leu Arg Gly Ser His 
        195                 200                 205             

Ser Ala Glu Leu Phe Phe Asp Asn Leu Glu Val Pro Ala Glu Asn Val 
    210                 215                 220                 

Leu Gly Arg Glu Gly Glu Gly Tyr Val Asn Ala Leu Lys Ile Leu Ala 
225                 230                 235                 240 

Asn Gly Arg Ala Gly Leu Ala Ala Arg Asn Leu Gly Ser Cys Ile Arg 
                245                 250                 255     

Leu Leu Glu Tyr Cys Met Glu Tyr Ala Glu Gln Arg Glu Gln Phe Gly 
            260                 265                 270         

Lys Pro Ile Ile Glu Gln Gln Ala Ile Gln His Met Leu Ala Glu Met 
        275                 280                 285             

Ser Met Leu Ile Glu Val Leu Arg Ser Thr Val Tyr Arg Val Ala Trp 
    290                 295                 300                 

Met Val Asp Gln Lys Met Arg Val Val Lys Glu Ala Ala Ile Ala Lys 
305                 310                 315                 320 

Leu Phe Gly Ser Glu Val Tyr Asn Lys Ile Ala Asp Met Ala Val Gln 
                325                 330                 335     

Ile His Gly Gly Leu Gly Tyr Met Lys Asp Tyr Pro Ile Glu Arg Tyr 
            340                 345                 350         

Phe Arg Asp Ala Arg Ile Thr Lys Ile Tyr Glu Gly Thr Ser Glu Ile 
        355                 360                 365             

Gln Arg Asn Ile Ile Ala Ser Glu Leu Arg Lys Glu Tyr Gly Lys Val 
    370                 375                 380                 

Arg Ala 
385     

<210>   718
<211>   385
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   718
Met Glu Phe Thr Leu Pro Ala Glu Ile Glu Phe Leu Lys Glu Asn Val 
                5                   10                  15      

Arg Lys Phe Val Arg Glu Val Val Glu Pro Val Ala Met Asp Ile Glu 
            20                  25                  30          

Glu Asn Asp His Ile Pro Glu Asp Ile Ile Glu Lys Ser Lys Glu Met 
        35                  40                  45              

Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr Gly Gly Leu Gly Leu 
    50                  55                  60                  

Ser Met Val Gly Lys Cys Ala Ile Tyr Glu Glu Leu Gly Lys Thr His 
65                  70                  75                  80  

Asn Gly Tyr Thr Thr Leu Ile Gly Ala His Thr Gly Ile Gly Thr Val 
                85                  90                  95      

Gly Ile Val Glu Leu Gly Thr Glu Glu Gln Lys Gln Arg Tyr Leu Pro 
            100                 105                 110         

Lys Met Ala Thr Gly Glu Trp Ile Gly Ala Phe Ala Leu Thr Glu Pro 
        115                 120                 125             

Ser Ala Gly Ser Asn Ala Ala Ala Leu Lys Thr Thr Ala Val Arg Lys 
    130                 135                 140                 

Gly Asp Arg Tyr Ile Ile Asn Gly Ser Lys His Tyr Ile Thr Asn Ala 
145                 150                 155                 160 

Val Asp Ala His Val Phe Thr Val Met Ala Val Thr Asp Pro Ser Lys 
                165                 170                 175     

Gly Pro Lys Gly Ile Thr Ser Phe Ile Val Glu Lys Asp Phe Pro Gly 
            180                 185                 190         

Phe Thr Ile Gly Asn Val Glu Arg Lys Met Gly Leu Arg Gly Ser His 
        195                 200                 205             

Ser Ala Glu Leu Phe Phe Asp Asn Leu Glu Val Pro Val Glu Asn Val 
    210                 215                 220                 

Leu Gly Lys Glu Gly Glu Gly Tyr Ile Asn Ala Leu Lys Ile Leu Ala 
225                 230                 235                 240 

Asn Gly Arg Ala Gly Leu Ala Ala Arg Asn Leu Gly Ser Cys Ile Arg 
                245                 250                 255     

Leu Leu Glu Tyr Cys Met Glu Tyr Ala Glu Gln Arg Glu Gln Phe Gly 
            260                 265                 270         

Lys Pro Ile Ile Glu Gln Gln Ala Ile Gln His Met Leu Ala Glu Met 
        275                 280                 285             

Ser Met Leu Ile Glu Val Leu Arg Ser Thr Val Tyr Arg Val Ala Trp 
    290                 295                 300                 

Met Val Asp Gln Lys Met Arg Val Val Lys Glu Ala Ala Ile Ala Lys 
305                 310                 315                 320 

Leu Phe Gly Ser Glu Val Tyr Asn Lys Ile Ala Asp Met Ala Val Gln 
                325                 330                 335     

Ile His Gly Gly Leu Gly Tyr Met Lys Asp Tyr Pro Ile Glu Arg Tyr 
            340                 345                 350         

Phe Arg Asp Ala Arg Ile Thr Lys Ile Tyr Glu Gly Thr Ser Glu Ile 
        355                 360                 365             

Gln Arg Asn Ile Ile Ala Asn Glu Leu Arg Lys Glu Tyr Gly Lys Val 
    370                 375                 380                 

Arg 
385 

<210>   719
<211>   382
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   719
Met Asp Phe Thr Ile Ser Glu Glu Leu Gln Met Met Val Gln Thr Val 
                5                   10                  15      

Lys Asp Phe Val Asp Asn Glu Val Asp Pro Ile Ser Gln Gln Ile Asp 
            20                  25                  30          

Glu Glu Asp Arg Val Pro Glu Glu Ile Ile Gln Lys Ala Arg Glu Leu 
        35                  40                  45              

Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr Gly Gly Val Gly Ser 
    50                  55                  60                  

Ile Gly Met Leu Gly Lys Cys Ile Ile Tyr Glu Gln Leu Gly Arg Thr 
65                  70                  75                  80  

Ala Asn Gly Phe Thr Thr Leu Ile Gly Ala His Thr Gly Ile Gly Thr 
                85                  90                  95      

Thr Gly Ile Val Glu Leu Gly Thr Glu Glu Gln Lys Arg Arg Tyr Leu 
            100                 105                 110         

Pro Asp Leu Ala Ser Gly Lys Lys Leu Ala Ala Phe Ala Leu Thr Glu 
        115                 120                 125             

Pro Glu Ala Gly Ser Asp Ala Ala Ser Ile Arg Thr Thr Ala Val Lys 
    130                 135                 140                 

Lys Gly Asp Arg Tyr Ile Leu Asn Gly Val Lys His Phe Ile Thr Asn 
145                 150                 155                 160 

Gly Pro Asp Ala Asp Val Phe Thr Ile Ile Ala Val Thr Asp Lys Ser 
                165                 170                 175     

Lys Gly Ala Lys Gly Gly Ile Thr Ala Phe Ile Val Glu Lys Asn Phe 
            180                 185                 190         

Pro Gly Phe Lys Val Gly Thr Ile Glu Lys Lys Met Gly Leu Arg Gly 
        195                 200                 205             

Ser His Thr Ser Glu Ile Ile Leu Glu Asp Cys Glu Val Pro Glu Glu 
    210                 215                 220                 

Asn Val Leu Gly Asn Val Gly Glu Gly Tyr Ile Asn Ala Leu Lys Ile 
225                 230                 235                 240 

Leu Ala Lys Gly Arg Val Gly Leu Ala Ala Arg Cys Val Gly Ser Met 
                245                 250                 255     

Gln Lys Leu Leu Glu Leu Ser Thr Arg Tyr Ala Gln Gln Arg Val Gln 
            260                 265                 270         

Phe Gly Lys Pro Ile Ser Ser Phe Gln Ala Ile Gln His Met Leu Ala 
        275                 280                 285             

Glu Met Ala Val Asp Ile Glu Ala Thr Arg Trp Phe Ala Tyr Arg Val 
    290                 295                 300                 

Ala Trp Leu Val Asp Gln Gly Ala Lys Val Ile Lys Glu Ala Ala Ala 
305                 310                 315                 320 

Val Lys Leu Phe Ala Ser Glu Ala Tyr Gly Arg Val Val Asp Lys Ala 
                325                 330                 335     

Val Gln Ile Phe Gly Gly Met Gly Tyr Met Lys Glu Phe Pro Ile Glu 
            340                 345                 350         

Arg Tyr Tyr Arg Asp Ala Arg Ile Thr Arg Ile Tyr Glu Gly Thr Ser 
        355                 360                 365             

Glu Ile Gln Lys Asn Ile Ile Ala Ser Gln Ile Leu Lys Glu 
    370                 375                 380         

<210>   720
<211>   381
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   720
Met Asn Phe Glu Leu Asp Glu Asp Ile Gln Ile Ile Lys Asp Asn Val 
                5                   10                  15      

Arg Asn Phe Ile Gln Thr Glu Val Glu Gln Val Ala Asp Asn Ile Glu 
            20                  25                  30          

Arg Asn Asn Lys Ile Pro Asp Arg Ile Ile Glu Leu Ser Lys Gln Met 
        35                  40                  45              

Gly Leu Phe Gly Leu Ser Ile Pro Glu Gln Tyr Gly Gly Leu Gly Ile 
    50                  55                  60                  

Gly Met Val Gly Lys Cys Ala Leu Tyr Glu Glu Ile Gly Val Thr His 
65                  70                  75                  80  

Asn Gly Tyr Thr Thr Leu Ile Gly Ala His Thr Gly Ile Gly Thr Val 
                85                  90                  95      

Gly Ile Val Glu Met Gly Asn Glu Gln Gln Lys Gln Lys Tyr Leu Pro 
            100                 105                 110         

Leu Met Ala Ser Gly Glu Lys Ile Gly Ala Phe Ala Leu Thr Glu Pro 
        115                 120                 125             

Glu Ala Gly Ser Asn Ala Ser Ala Leu Lys Thr Ser Ala Ile Lys Lys 
    130                 135                 140                 

Lys Asp Lys Tyr Ile Leu Asn Gly Thr Lys His Tyr Ile Thr Asn Ala 
145                 150                 155                 160 

Thr Glu Ala Glu Val Phe Thr Val Met Ala Val Thr Asp Pro Ala Lys 
                165                 170                 175     

Gly Ala Lys Gly Ile Ser Ser Phe Ile Val Glu Lys Ser Asn Leu Gly 
            180                 185                 190         

Phe His Val Gly Ala Val Glu Glu Lys Met Gly Leu Lys Gly Ser His 
        195                 200                 205             

Ser Ala Glu Ile Ile Leu Asp Asp Cys Glu Val Ser Val Glu Asn Leu 
    210                 215                 220                 

Leu Gly Glu Glu Gly Gln Gly Tyr Val Asn Ala Leu Lys Ile Leu Thr 
225                 230                 235                 240 

Asn Gly Arg Ala Gly Leu Ala Ala Arg Asn Leu Gly Ser Cys Gln Lys 
                245                 250                 255     

Leu Leu Asp Met Ser Thr Thr Tyr Ala Ile Glu Arg Gln Gln Phe Gly 
            260                 265                 270         

Thr Ser Ile Ile Asp His Gln Ala Val Ala His Met Leu Ala Glu Met 
        275                 280                 285             

Ala Val Glu Ile Glu Ala Leu Arg Ala Leu Thr Tyr Lys Val Ala Trp 
    290                 295                 300                 

Met Val Asp Asn Gly Glu Asn Val Ile Lys Glu Ala Ala Met Leu Lys 
305                 310                 315                 320 

Leu Tyr Gly Ser Glu Val Tyr Asn Arg Val Ala Asp Lys Ala Val Gln 
                325                 330                 335     

Val His Gly Gly Ile Gly Tyr Ile Ser Asp Phe Pro Val Glu Arg Tyr 
            340                 345                 350         

Tyr Arg Asp Ala Arg Ile Thr Arg Ile Tyr Glu Gly Thr Ser Glu Ile 
        355                 360                 365             

Gln Lys Asn Ile Ile Ala Gly Gln Leu Lys Lys His Tyr 
    370                 375                 380     

<210>   721
<211>   378
<212>   PRT
<213>   Deinococcus radiodurans R1

<400>   721
Met Asp Phe Asn Leu Pro Asp Asp Leu Arg Glu Val Gln Ala Thr Ile 
                5                   10                  15      

Arg Asp Phe Met Leu Thr Arg Val Glu Asp Arg Ala Gln Glu Ile Glu 
            20                  25                  30          

His Thr Asn Ser Val Pro Pro Glu Leu Ile Lys Glu Ala Ala Asp Leu 
        35                  40                  45              

Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr Gly Gly Val Gly Leu 
    50                  55                  60                  

Ser Ser Leu Gly Arg Cys Ala Val Tyr Glu Ala Met Gly Gln Gly His 
65                  70                  75                  80  

Met Gly Phe Gly Gly Met Ile Ser Ala His Ala Ser Ile Gly Thr Ser 
                85                  90                  95      

Gly Leu Val Lys Leu Gly Asn Glu Glu Gln Lys Gln Arg Phe Leu Pro 
            100                 105                 110         

Arg Met Ala Ala Gly Glu Cys Ile Ala Gly Phe Ala Ile Thr Glu Pro 
        115                 120                 125             

Ser Ser Gly Ser Asp Ala Gly Asn Ile Arg Thr Lys Ala Val Lys Lys 
    130                 135                 140                 

Gly Asp Val Tyr Val Leu Asn Gly Thr Lys His Tyr Ile Ser Asn Ala 
145                 150                 155                 160 

Pro Ile Ala Gly Leu Leu Thr Val Ile Ala Ile Thr Asp Pro Ala Gln 
                165                 170                 175     

Gly Ser Arg Gly Met Ser Ala Phe Leu Val Glu Pro Gln Ser Thr Pro 
            180                 185                 190         

Gly Val Ser Ile Gly Lys Ile Asp Glu Lys Met Gly Gln Lys Gly Ala 
        195                 200                 205             

Leu Ser Ala Glu Val Ile Phe Glu Asp Ala Glu Ile Pro Ala Ala Asn 
    210                 215                 220                 

Leu Leu Gly Pro Glu Asn Arg Gly Tyr Arg Glu Ala Leu Gly Ile Leu 
225                 230                 235                 240 

Thr Asn Gly Arg Val Gly Ile Ala Ala Arg Ser Thr Gly Ala Met Gln 
                245                 250                 255     

Arg Leu Leu Asp Leu Ser Val Ala His Ala Gln Thr Arg Glu Gln Phe 
            260                 265                 270         

Gly Lys Pro Ile Ala Glu Phe Gln Ala Val Gln Phe Met Leu Ala Glu 
        275                 280                 285             

Met Glu Val Ala Ile Gln Thr Ser Arg Val Leu Trp Gln Lys Val Ala 
    290                 295                 300                 

Trp Met Val Asp Gln Gly Gln Asp Val Lys Arg Met Ala Ser Val Ala 
305                 310                 315                 320 

Lys Tyr His Ala Thr Glu Met Leu Ser Gln Val Ala Asp Lys Ala Val 
                325                 330                 335     

Gln Val Ala Gly Gly Met Gly Tyr Val Lys Asp Ala Pro Phe Glu Arg 
            340                 345                 350         

Phe Tyr Arg Asp Gln Arg Leu Leu Arg Ile Tyr Glu Gly Thr Ser Glu 
        355                 360                 365             

Ile Gln Lys Val Ile Ile Ala Ala Glu Leu 
    370                 375             

<210>   722
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   722
Met Asp Val Ser Arg Val Asp Phe Thr Leu Pro Ser Glu Leu Glu Glu 
                5                   10                  15      

Met Arg Arg Thr Ile Arg Asp Phe Val Glu His Glu Val Glu Pro Leu 
            20                  25                  30          

Ala Met Gln Ile Glu Glu Glu Asp Arg Val Pro Asp Ser Val Leu Glu 
        35                  40                  45              

Lys Ser Lys Glu Leu Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr 
    50                  55                  60                  

Gly Gly Ile Gly Leu Ser Met Leu Gly Lys Cys Val Ile Tyr Glu Glu 
65                  70                  75                  80  

Leu Gly Lys Thr Ile Asn Gly Tyr Thr Thr Ile Ile Gly Ala His Asn 
                85                  90                  95      

Gly Ile Gly Ser Val Gly Ile Val Glu Phe Gly Thr Lys Glu Gln Lys 
            100                 105                 110         

Glu Lys Tyr Leu Pro Lys Met Ala Thr Gly Glu Trp Ile Gly Ala Phe 
        115                 120                 125             

Ala Leu Thr Glu Pro Gln Ala Gly Ser Asn Ala Ala Ala Ile Lys Thr 
    130                 135                 140                 

Thr Ala Val Lys Lys Gly Asp Arg Tyr Ile Leu Asn Gly Gln Lys Ile 
145                 150                 155                 160 

Tyr Ile Thr Asn Ala Pro Tyr Ala His Val Phe Thr Val Met Ala Val 
                165                 170                 175     

Thr Asp Pro Ser Lys Gly Ala Lys Gly Ile Thr Ser Phe Ile Val Glu 
            180                 185                 190         

Arg Asp Phe Pro Gly Phe Arg Val Gly His Ile Glu Lys Lys Met Gly 
        195                 200                 205             

Leu His Gly Ser His Thr Ala Gln Ile Phe Phe Glu Asp Met Glu Val 
    210                 215                 220                 

Pro Glu Glu Asn Val Leu Gly Arg Glu Gly Glu Gly Tyr Val Asn Ala 
225                 230                 235                 240 

Leu Lys Ile Leu Ala Asn Gly Arg Ala Gly Leu Ala Ala Arg Cys Leu 
                245                 250                 255     

Gly Ser Cys Glu Tyr Leu Leu Asp Lys Ser Leu Ala Phe Ala His Glu 
            260                 265                 270         

Arg Ile Gln Phe Gly Lys Pro Ile Phe Glu Gln Gln Ile Ile Gln His 
        275                 280                 285             

Tyr Leu Ala Glu Met Ala Leu Glu Ile Glu Leu Leu Arg Thr Phe Val 
    290                 295                 300                 

Tyr Arg Val Ala Trp Met Thr Asp Gln Lys Met Asn Val Ile Lys Glu 
305                 310                 315                 320 

Ala Ala Met Leu Lys Leu Tyr Gly Ser Glu Val Tyr Asn Arg Val Ala 
                325                 330                 335     

Asp Lys Ala Val Gln Ile His Gly Gly Leu Gly Phe Ile Ala Glu Tyr 
            340                 345                 350         

Pro Ile Glu Arg Phe Tyr Arg Asp Ala Arg Ile Thr Arg Ile Tyr Glu 
        355                 360                 365             

Gly Thr Ser Glu Ile Gln Lys Asn Ile Ile Ala Ala Gln Leu His Lys 
    370                 375                 380                 

Glu Tyr Glu Arg Thr Lys Ala Asp Ala 
385                 390             

<210>   723
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   723
Met Glu Val Ser Arg Val Asp Phe Thr Leu Pro Ser Glu Leu Glu Glu 
                5                   10                  15      

Met Arg Arg Thr Ile Arg Asp Phe Val Glu His Glu Val Glu Pro Leu 
            20                  25                  30          

Ala Met Gln Ile Glu Glu Glu Asp Arg Val Pro Asp Ser Val Leu Glu 
        35                  40                  45              

Lys Ser Lys Glu Leu Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr 
    50                  55                  60                  

Gly Gly Ile Gly Leu Ser Met Leu Gly Lys Cys Val Ile Tyr Glu Glu 
65                  70                  75                  80  

Leu Gly Lys Thr Ile Asn Gly Tyr Thr Thr Ile Ile Gly Ala His Asn 
                85                  90                  95      

Gly Ile Gly Ser Val Gly Ile Val Glu Phe Gly Thr Lys Glu Gln Lys 
            100                 105                 110         

Glu Lys Tyr Leu Pro Lys Met Ala Thr Gly Glu Trp Ile Gly Ala Phe 
        115                 120                 125             

Ala Leu Thr Glu Pro Gln Ala Gly Ser Asn Ala Ala Ala Ile Lys Thr 
    130                 135                 140                 

Thr Ala Val Lys Lys Gly Asp Arg Tyr Ile Leu Asn Gly Gln Lys Ile 
145                 150                 155                 160 

Tyr Ile Thr Asn Ala Pro Tyr Ala His Val Phe Thr Val Met Ala Val 
                165                 170                 175     

Thr Asp Pro Ser Lys Gly Ala Lys Gly Ile Thr Ser Phe Ile Val Glu 
            180                 185                 190         

Arg Asp Phe Pro Gly Phe Arg Val Gly His Ile Glu Lys Lys Met Gly 
        195                 200                 205             

Leu His Gly Ser His Thr Ala Gln Ile Phe Phe Glu Asp Met Glu Val 
    210                 215                 220                 

Pro Glu Glu Asn Val Leu Gly Arg Glu Gly Glu Gly Tyr Val Asn Ala 
225                 230                 235                 240 

Leu Lys Ile Leu Ala Asn Gly Arg Ala Gly Leu Ala Ala Arg Cys Leu 
                245                 250                 255     

Gly Ser Cys Glu Tyr Leu Leu Asp Lys Ser Leu Ala Phe Ala His Glu 
            260                 265                 270         

Arg Ile Gln Phe Gly Lys Pro Ile Phe Glu Gln Gln Ile Ile Gln His 
        275                 280                 285             

Tyr Leu Ala Glu Met Ala Leu Glu Ile Glu Ile Leu Arg Thr Phe Val 
    290                 295                 300                 

Tyr Arg Val Ala Trp Met Thr Asp Gln Lys Met Asn Val Ile Lys Glu 
305                 310                 315                 320 

Ala Ala Met Leu Lys Leu Tyr Gly Ser Glu Val Tyr Asn Arg Val Ala 
                325                 330                 335     

Asp Lys Ala Val Gln Ile His Gly Gly Leu Gly Phe Ile Ala Glu Tyr 
            340                 345                 350         

Pro Ile Glu Arg Phe Tyr Arg Asp Ala Arg Ile Thr Arg Ile Tyr Glu 
        355                 360                 365             

Gly Thr Ser Glu Ile Gln Lys Asn Ile Ile Ala Ala Gln Leu His Lys 
    370                 375                 380                 

Glu Tyr Glu Arg Thr Lys Ala Asp Ala 
385                 390             

<210>   724
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   724
Met Glu Val Ser Arg Val Asp Phe Thr Leu Pro Ser Glu Leu Glu Glu 
                5                   10                  15      

Met Arg Arg Thr Ile Arg Asp Phe Val Glu His Glu Val Glu Pro Leu 
            20                  25                  30          

Ala Met Gln Ile Glu Glu Glu Asp Lys Val Pro Asp Ser Val Leu Glu 
        35                  40                  45              

Lys Ser Lys Glu Leu Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr 
    50                  55                  60                  

Gly Gly Ile Gly Leu Ser Met Leu Gly Lys Cys Val Ile Tyr Glu Glu 
65                  70                  75                  80  

Leu Gly Lys Thr Ile Asn Gly Tyr Thr Thr Ile Ile Gly Ala His Asn 
                85                  90                  95      

Gly Ile Gly Ser Val Gly Ile Val Glu Phe Gly Thr Lys Glu Gln Lys 
            100                 105                 110         

Glu Lys Tyr Leu Pro Lys Met Ala Thr Gly Glu Trp Ile Gly Ala Phe 
        115                 120                 125             

Ala Leu Thr Glu Pro Gln Ala Gly Ser Asn Ala Ala Ala Ile Lys Thr 
    130                 135                 140                 

Thr Ala Val Lys Lys Gly Asp Arg Tyr Ile Leu Asn Gly Gln Lys Ile 
145                 150                 155                 160 

Tyr Ile Thr Asn Ala Pro Tyr Ala His Val Phe Thr Val Met Ala Val 
                165                 170                 175     

Thr Asp Pro Ser Lys Gly Ala Lys Gly Ile Thr Ser Phe Ile Val Glu 
            180                 185                 190         

Arg Asp Phe Pro Gly Phe Arg Val Gly His Ile Glu Lys Lys Met Gly 
        195                 200                 205             

Leu His Gly Ser His Thr Ala Gln Ile Phe Phe Glu Asp Met Glu Val 
    210                 215                 220                 

Pro Glu Glu Asn Val Leu Gly Arg Glu Gly Glu Gly Tyr Val Asn Ala 
225                 230                 235                 240 

Leu Lys Ile Leu Ala Asn Gly Arg Ala Gly Leu Ala Ala Arg Cys Leu 
                245                 250                 255     

Gly Ser Cys Glu Tyr Leu Leu Asp Lys Ser Leu Ala Phe Ala His Glu 
            260                 265                 270         

Arg Ile Gln Phe Gly Lys Pro Ile Phe Glu Gln Gln Ile Ile Gln His 
        275                 280                 285             

Tyr Leu Ala Glu Met Ala Leu Glu Ile Glu Leu Leu Arg Thr Phe Val 
    290                 295                 300                 

Tyr Arg Val Ala Trp Met Thr Asp Gln Lys Met Asn Val Ile Lys Glu 
305                 310                 315                 320 

Ala Ala Met Leu Lys Leu Tyr Gly Ser Glu Val Tyr Asn Arg Val Ala 
                325                 330                 335     

Asp Lys Ala Val Gln Ile His Gly Gly Leu Gly Phe Ile Ala Glu Tyr 
            340                 345                 350         

Pro Ile Glu Arg Phe Tyr Arg Asp Ala Arg Ile Thr Arg Ile Tyr Glu 
        355                 360                 365             

Gly Thr Ser Glu Ile Gln Lys Asn Ile Ile Ala Ala Gln Leu His Lys 
    370                 375                 380                 

Glu Tyr Glu Arg Thr Lys Ala Asp Ala 
385                 390             

<210>   725
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   725
Met Glu Val Ser Arg Val Asp Phe Thr Leu Pro Ser Glu Leu Glu Glu 
                5                   10                  15      

Met Arg Arg Thr Ile Arg Asp Phe Val Glu His Glu Val Glu Pro Leu 
            20                  25                  30          

Ala Met Gln Ile Glu Glu Glu Asp Arg Val Pro Asp Ser Val Leu Glu 
        35                  40                  45              

Lys Ser Lys Glu Leu Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr 
    50                  55                  60                  

Gly Gly Ile Gly Leu Ser Met Leu Gly Lys Cys Val Ile Tyr Glu Glu 
65                  70                  75                  80  

Leu Gly Lys Thr Ile Asn Gly Tyr Thr Thr Ile Ile Gly Ala His Asn 
                85                  90                  95      

Gly Ile Gly Ser Val Gly Ile Val Glu Phe Gly Thr Lys Glu Gln Lys 
            100                 105                 110         

Glu Lys Tyr Leu Pro Lys Met Ala Thr Gly Glu Trp Ile Gly Ala Phe 
        115                 120                 125             

Ala Leu Thr Glu Pro Gln Ala Gly Ser Asn Ala Ala Ala Ile Lys Thr 
    130                 135                 140                 

Thr Ala Val Lys Lys Gly Asp Arg Tyr Ile Leu Asn Gly Gln Lys Ile 
145                 150                 155                 160 

Tyr Ile Thr Asn Ala Pro Tyr Ala His Val Phe Thr Val Met Ala Val 
                165                 170                 175     

Thr Asp Pro Ser Lys Gly Ala Lys Gly Ile Thr Ser Phe Ile Val Glu 
            180                 185                 190         

Arg Asp Phe Pro Gly Phe Arg Val Gly His Ile Glu Lys Lys Met Gly 
        195                 200                 205             

Leu His Gly Ser His Thr Ala Gln Ile Phe Phe Glu Asp Met Glu Val 
    210                 215                 220                 

Pro Asp Glu Asn Val Leu Gly Arg Glu Gly Glu Gly Tyr Val Asn Ala 
225                 230                 235                 240 

Leu Lys Ile Leu Ala Asn Gly Arg Ala Gly Leu Ala Ala Arg Cys Leu 
                245                 250                 255     

Gly Ser Cys Glu Tyr Leu Leu Asp Lys Ser Leu Ala Phe Ala His Glu 
            260                 265                 270         

Arg Ile Gln Phe Gly Lys Pro Ile Phe Glu Gln Gln Ile Ile Gln His 
        275                 280                 285             

Tyr Leu Ala Glu Met Ala Leu Glu Ile Glu Leu Leu Arg Thr Phe Val 
    290                 295                 300                 

Tyr Arg Val Ala Trp Met Thr Asp Gln Lys Met Asn Val Ile Lys Glu 
305                 310                 315                 320 

Ala Ala Met Leu Lys Leu Tyr Gly Ser Glu Val Tyr Asn Arg Val Ala 
                325                 330                 335     

Asp Lys Ala Val Gln Ile His Gly Gly Leu Gly Phe Ile Ala Glu Tyr 
            340                 345                 350         

Pro Ile Glu Arg Phe Tyr Arg Asp Ala Arg Ile Thr Arg Ile Tyr Glu 
        355                 360                 365             

Gly Thr Ser Glu Ile Gln Lys Asn Ile Ile Ala Ala Gln Leu His Lys 
    370                 375                 380                 

Glu Tyr Glu Arg Thr Lys Ala Asp Ala 
385                 390             

<210>   726
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   726
Met Glu Val Ser Arg Val Asp Phe Thr Leu Pro Ser Glu Leu Glu Glu 
                5                   10                  15      

Met Arg Arg Thr Ile Arg Asp Phe Val Glu His Glu Val Glu Pro Leu 
            20                  25                  30          

Ala Met Gln Ile Glu Glu Glu Asp Arg Val Pro Asp Ser Val Leu Glu 
        35                  40                  45              

Lys Ser Lys Glu Leu Gly Leu Phe Gly Leu Ser Ile Pro Glu Glu Tyr 
    50                  55                  60                  

Gly Gly Ile Gly Leu Ser Met Leu Gly Lys Cys Val Ile Tyr Glu Glu 
65                  70                  75                  80  

Leu Gly Lys Thr Ile Asn Gly Tyr Thr Thr Ile Ile Gly Ala His Asn 
                85                  90                  95      

Gly Ile Gly Ser Val Gly Ile Val Glu Phe Gly Thr Lys Glu Gln Lys 
            100                 105                 110         

Glu Lys Tyr Leu Pro Lys Met Ala Thr Gly Glu Trp Ile Gly Ala Phe 
        115                 120                 125             

Ala Leu Thr Glu Pro Gln Ala Gly Ser Asn Ala Ala Ala Ile Lys Thr 
    130                 135                 140                 

Thr Ala Val Lys Lys Gly Asp Arg Tyr Ile Leu Asn Gly Gln Lys Ile 
145                 150                 155                 160 

Tyr Ile Thr Asn Ala Pro Tyr Ala His Val Phe Thr Val Met Ala Val 
                165                 170                 175     

Thr Asp Pro Ser Lys Gly Ala Lys Gly Ile Thr Ser Phe Ile Val Glu 
            180                 185                 190         

Arg Asp Phe Pro Gly Phe Arg Val Gly His Ile Glu Lys Lys Met Gly 
        195                 200                 205             

Leu His Gly Ser His Thr Ala Gln Ile Phe Phe Glu Asp Met Glu Val 
    210                 215                 220                 

Pro Glu Glu Asn Val Leu Gly Arg Glu Gly Glu Gly Tyr Val Asn Ala 
225                 230                 235                 240 

Leu Lys Ile Leu Ala Asn Gly Arg Ala Gly Leu Ala Ala Arg Cys Leu 
                245                 250                 255     

Gly Ser Cys Glu Tyr Leu Leu Asp Lys Ser Ile Ala Phe Ala His Glu 
            260                 265                 270         

Arg Ile Gln Phe Gly Lys Pro Ile Phe Glu Gln Gln Ile Ile Gln His 
        275                 280                 285             

Tyr Leu Ala Glu Met Ala Leu Glu Ile Glu Leu Leu Arg Thr Phe Val 
    290                 295                 300                 

Tyr Arg Val Ala Trp Met Thr Asp Gln Lys Met Asn Val Ile Lys Glu 
305                 310                 315                 320 

Ala Ala Met Leu Lys Leu Tyr Gly Ser Glu Val Tyr Asn Arg Val Ala 
                325                 330                 335     

Asp Lys Ala Val Gln Ile His Gly Gly Leu Gly Phe Ile Ala Glu Tyr 
            340                 345                 350         

Pro Ile Glu Arg Phe Tyr Arg Asp Ala Arg Ile Thr Arg Ile Tyr Glu 
        355                 360                 365             

Gly Thr Ser Glu Ile Gln Lys Asn Ile Ile Ala Ala Gln Leu His Lys 
    370                 375                 380                 

Glu Tyr Glu Arg Thr Lys Ala Asp Ala 
385                 390             

<210>   727
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   727
gtggatgtga gtcgcgtgga ctttacgctc ccatccgagc tggaagagat gaggcggacc       60

attcgcgact ttgtggaaca cgaggttgaa ccgctcgcca tgcagattga ggaagaggat      120

cgcgtgccgg acagcgtgct ggaaaaatcg aaggagcttg gactgtttgg cctcagcatc      180

cccgaggagt acggtggcat cggcctcagc atgctgggca agtgcgtcat ctacgaggag      240

ctcggcaaga ccatcaacgg ctacacgacc atcatcggcg cgcacaacgg cattggttcg      300

gtcggcatcg tggagtttgg caccaaggag cagaaggaga aatacctgcc caagatggcg      360

acgggtgagt ggatcggcgc gtttgcgctc accgagccgc aggccggatc gaacgcggcg      420

gccattaaga cgacggcggt aaagaagggc gataggtaca tcctcaacgg ccagaagatc      480

tacatcacaa acgcgccgta tgcgcacgtg ttcacggtga tggcggtcac ggatccgtcc      540

aaaggggcga agggcatcac ctcgttcatc gtcgaacgcg actttccagg ttttcgtgtg      600

ggacacattg aaaagaagat ggggctgcat ggatcacaca cggcgcagat cttcttcgag      660

gacatggagg ttccggagga gaacgtcctg ggccgagagg gcgaaggata tgtcaacgcg      720

ctcaagattc tggccaacgg ccgagcaggg ctcgcggcga ggtgcctggg ttcctgtgaa      780

tatctgctgg acaaatcgct ggcgtttgcg cacgagcgca tccagttcgg caagcccatc      840

tttgaacagc agatcatcca gcactacctc gcggagatgg cgctcgagat cgaactgctg      900

cgcacctttg tctaccgcgt ggcgtggatg acggatcaga aaatgaacgt catcaaggaa      960

gctgcgatgc tgaagctata cgggtccgag gtctacaacc gcgtggcgga caaggcggtc     1020

cagatccacg gcgggctcgg tttcatcgcg gagtatccca tcgagcggtt ctatcgcgat     1080

gcgcgcatca cgaggatcta cgagggaacg tccgagatcc aaaagaacat cattgccgca     1140

cagctgcaca aggagtacga gcgcaccaag gcggatgcgt ga                        1182


<210>   728
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   728
gtggaggtga gtcgcgtgga ctttacgctc ccatccgagc tggaagagat gaggcggacc       60

attcgcgact ttgtggaaca cgaggttgaa ccgctcgcca tgcagattga ggaagaggat      120

cgcgtgccgg acagcgtgct ggaaaaatcg aaggagcttg gactgtttgg cctcagcatc      180

cccgaggagt acggtggcat cggcctcagc atgctgggca agtgcgtcat ctacgaggag      240

ctcggcaaga ccatcaacgg ctacacgacc atcatcggcg cgcacaacgg cattggttcg      300

gtcggcatcg tggagtttgg caccaaggag cagaaggaga aatacctgcc caagatggcg      360

acgggtgagt ggatcggcgc gtttgcgctc accgagccgc aggccggatc gaacgcggcg      420

gccattaaga cgacggcggt aaagaagggc gataggtaca tcctcaacgg ccagaagatc      480

tacatcacaa acgcgccgta tgcgcacgtg ttcacggtga tggcggtcac ggatccgtcc      540

aaaggggcga agggcatcac ctcgttcatc gtcgaacgcg actttccagg ttttcgtgtg      600

ggacacattg aaaagaagat ggggctgcat ggatcacaca cggcgcagat cttcttcgag      660

gacatggagg ttccggagga gaacgtcctg ggccgagagg gcgaaggata tgtcaacgcg      720

ctcaagattc tggccaacgg ccgagcaggg ctcgcggcga ggtgcctggg ttcctgtgaa      780

tatctgctgg acaaatcgct ggcgtttgcg cacgagcgca tccagttcgg caagcccatc      840

tttgaacagc agatcatcca gcactacctc gcggagatgg cgctcgagat cgaaattctg      900

cgcacctttg tctaccgcgt ggcgtggatg acggatcaga aaatgaacgt catcaaggaa      960

gctgcgatgc tgaagctata cgggtccgag gtctacaacc gcgtggcgga caaggcggtc     1020

cagatccacg gcgggctcgg tttcatcgcg gagtatccca tcgagcggtt ctatcgcgat     1080

gcgcgcatca cgaggatcta cgagggaacg tccgagatcc aaaagaacat cattgccgca     1140

cagctgcaca aggagtacga gcgcaccaag gcggatgcgt ga                        1182


<210>   729
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   729
gtggaggtga gtcgcgtgga ctttacgctc ccatccgagc tggaagagat gaggcggacc       60

attcgcgact ttgtggaaca cgaggttgaa ccgctcgcca tgcagattga ggaagaggat      120

aaagtgccgg acagcgtgct ggaaaaatcg aaggagcttg gactgtttgg cctcagcatc      180

cccgaggagt acggtggcat cggcctcagc atgctgggca agtgcgtcat ctacgaggag      240

ctcggcaaga ccatcaacgg ctacacgacc atcatcggcg cgcacaacgg cattggttcg      300

gtcggcatcg tggagtttgg caccaaggag cagaaggaga aatacctgcc caagatggcg      360

acgggtgagt ggatcggcgc gtttgcgctc accgagccgc aggccggatc gaacgcggcg      420

gccattaaga cgacggcggt aaagaagggc gataggtaca tcctcaacgg ccagaagatc      480

tacatcacaa acgcgccgta tgcgcacgtg ttcacggtga tggcggtcac ggatccgtcc      540

aaaggggcga agggcatcac ctcgttcatc gtcgaacgcg actttccagg ttttcgtgtg      600

ggacacattg aaaagaagat ggggctgcat ggatcacaca cggcgcagat cttcttcgag      660

gacatggagg ttccggagga gaacgtcctg ggccgagagg gcgaaggata tgtcaacgcg      720

ctcaagattc tggccaacgg ccgagcaggg ctcgcggcga ggtgcctggg ttcctgtgaa      780

tatctgctgg acaaatcgct ggcgtttgcg cacgagcgca tccagttcgg caagcccatc      840

tttgaacagc agatcatcca gcactacctc gcggagatgg cgctcgagat cgaactgctg      900

cgcacctttg tctaccgcgt ggcgtggatg acggatcaga aaatgaacgt catcaaggaa      960

gctgcgatgc tgaagctata cgggtccgag gtctacaacc gcgtggcgga caaggcggtc     1020

cagatccacg gcgggctcgg tttcatcgcg gagtatccca tcgagcggtt ctatcgcgat     1080

gcgcgcatca cgaggatcta cgagggaacg tccgagatcc aaaagaacat cattgccgca     1140

cagctgcaca aggagtacga gcgcaccaag gcggatgcgt ga                        1182


<210>   730
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   730
gtggaggtga gtcgcgtgga ctttacgctc ccatccgagc tggaagagat gaggcggacc       60

attcgcgact ttgtggaaca cgaggttgaa ccgctcgcca tgcagattga ggaagaggat      120

cgcgtgccgg acagcgtgct ggaaaaatcg aaggagcttg gactgtttgg cctcagcatc      180

cccgaggagt acggtggcat cggcctcagc atgctgggca agtgcgtcat ctacgaggag      240

ctcggcaaga ccatcaacgg ctacacgacc atcatcggcg cgcacaacgg cattggttcg      300

gtcggcatcg tggagtttgg caccaaggag cagaaggaga aatacctgcc caagatggcg      360

acgggtgagt ggatcggcgc gtttgcgctc accgagccgc aggccggatc gaacgcggcg      420

gccattaaga cgacggcggt aaagaagggc gataggtaca tcctcaacgg ccagaagatc      480

tacatcacaa acgcgccgta tgcgcacgtg ttcacggtga tggcggtcac ggatccgtcc      540

aaaggggcga agggcatcac ctcgttcatc gtcgaacgcg actttccagg ttttcgtgtg      600

ggacacattg aaaagaagat ggggctgcat ggatcacaca cggcgcagat cttcttcgag      660

gacatggagg ttccggatga gaacgtcctg ggccgagagg gcgaaggata tgtcaacgcg      720

ctcaagattc tggccaacgg ccgagcaggg ctcgcggcga ggtgcctggg ttcctgtgaa      780

tatctgctgg acaaatcgct ggcgtttgcg cacgagcgca tccagttcgg caagcccatc      840

tttgaacagc agatcatcca gcactacctc gcggagatgg cgctcgagat cgaactgctg      900

cgcacctttg tctaccgcgt ggcgtggatg acggatcaga aaatgaacgt catcaaggaa      960

gctgcgatgc tgaagctata cgggtccgag gtctacaacc gcgtggcgga caaggcggtc     1020

cagatccacg gcgggctcgg tttcatcgcg gagtatccca tcgagcggtt ctatcgcgat     1080

gcgcgcatca cgaggatcta cgagggaacg tccgagatcc aaaagaacat cattgccgca     1140

cagctgcaca aggagtacga gcgcaccaag gcggatgcgt ga                        1182


<210>   731
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   731
gtggaggtga gtcgcgtgga ctttacgctc ccatccgagc tggaagagat gaggcggacc       60

attcgcgact ttgtggaaca cgaggttgaa ccgctcgcca tgcagattga ggaagaggat      120

cgcgtgccgg acagcgtgct ggaaaaatcg aaggagcttg gactgtttgg cctcagcatc      180

cccgaggagt acggtggcat cggcctcagc atgctgggca agtgcgtcat ctacgaggag      240

ctcggcaaga ccatcaacgg ctacacgacc atcatcggcg cgcacaacgg cattggttcg      300

gtcggcatcg tggagtttgg caccaaggag cagaaggaga aatacctgcc caagatggcg      360

acgggtgagt ggatcggcgc gtttgcgctc accgagccgc aggccggatc gaacgcggcg      420

gccattaaga cgacggcggt aaagaagggc gataggtaca tcctcaacgg ccagaagatc      480

tacatcacaa acgcgccgta tgcgcacgtg ttcacggtga tggcggtcac ggatccgtcc      540

aaaggggcga agggcatcac ctcgttcatc gtcgaacgcg actttccagg ttttcgtgtg      600

ggacacattg aaaagaagat ggggctgcat ggatcacaca cggcgcagat cttcttcgag      660

gacatggagg ttccggagga gaacgtcctg ggccgagagg gcgaaggata tgtcaacgcg      720

ctcaagattc tggccaacgg ccgagcaggg ctcgcggcga ggtgcctggg ttcctgtgaa      780

tatctgctgg acaaatcgat tgcgtttgcg cacgagcgca tccagttcgg caagcccatc      840

tttgaacagc agatcatcca gcactacctc gcggagatgg cgctcgagat cgaactgctg      900

cgcacctttg tctaccgcgt ggcgtggatg acggatcaga aaatgaacgt catcaaggaa      960

gctgcgatgc tgaagctata cgggtccgag gtctacaacc gcgtggcgga caaggcggtc     1020

cagatccacg gcgggctcgg tttcatcgcg gagtatccca tcgagcggtt ctatcgcgat     1080

gcgcgcatca cgaggatcta cgagggaacg tccgagatcc aaaagaacat cattgccgca     1140

cagctgcaca aggagtacga gcgcaccaag gcggatgcgt ga                        1182


<210>   732
<211>   389
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   732
Met Thr His Val Thr Ser Ile Gly Ala Lys Gly Glu Ala Pro His Ile 
                5                   10                  15      

Leu Leu Ala Pro Asp Ser Phe Lys Gly Ser Leu Thr Ala Arg Glu Ala 
            20                  25                  30          

Ala Glu Ala Met Ala Glu Gly Val Ser Arg Ala Cys Pro Ser Ala Gln 
        35                  40                  45              

Leu Ala Leu Val Pro Ile Ala Asp Gly Gly Glu Gly Thr Leu Ala Ala 
    50                  55                  60                  

Ile Ala Thr Ser Thr Arg Ala Arg Trp Leu Ser Thr Glu Val Thr Ala 
65                  70                  75                  80  

Ala Ser Gly Gln Pro Lys Gln Gly Arg Phe Leu Ala Leu Pro Asp Gly 
                85                  90                  95      

Thr Ala Val Val Glu Cys Ala Glu Ala Val Gly Leu Pro Glu Ala Leu 
            100                 105                 110         

Arg Ser Gly Ala Asp Val Trp Arg Arg Thr Thr Val Gly Val Gly Glu 
        115                 120                 125             

Met Ile Arg His Ala Leu Glu Thr Gly His Arg Arg Ile Ala Val Ala 
    130                 135                 140                 

Leu Gly Gly Ser Ala Thr Asn Asp Ala Gly Val Gly Met Leu Ala Ala 
145                 150                 155                 160 

Leu Gly Val Arg Leu Leu Asp Asp Ala Gly Gln Asp Val Pro Pro Val 
                165                 170                 175     

Pro Ala Glu Phe His Arg Val Ala Arg Val Asp Val Ser Gly Leu Asp 
            180                 185                 190         

Glu Arg Leu Arg Gly Ala Glu Met Leu Ala Val Cys Asp Val Asp Asn 
        195                 200                 205             

Pro Leu Thr Gly Glu Asn Gly Ala Thr Thr Val Phe Gly Pro Gln Lys 
    210                 215                 220                 

Gly Val Ser Thr His Asp Val Pro Arg Leu Asp Glu Ala Leu Ala His 
225                 230                 235                 240 

Leu Ala Ala Arg Cys Glu Ala Ala Phe Gly Cys Lys Ala Ala Asp Leu 
                245                 250                 255     

Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Phe Ala Leu Tyr Leu Leu 
            260                 265                 270         

Gly Ala Ala Arg Val Ser Gly Ile Asp Phe Val Leu Asp Ala Val Gly 
        275                 280                 285             

Phe Asp His Ala Leu Glu Arg Ala Ala Leu Val Leu Thr Gly Glu Gly 
    290                 295                 300                 

Arg Thr Asp Ala Gln Thr Ala His Gly Lys Ala Val Ala Gly Val Ala 
305                 310                 315                 320 

Arg Arg Ala Lys Ala Arg Gly Val Pro Val Phe Cys Ile Ser Gly Ala 
                325                 330                 335     

Ile Gly Pro Gly Ala Glu Arg Leu Tyr Asp His Gly Val Ser Ala Leu 
            340                 345                 350         

Phe Ala Thr Ala Pro Gly Pro Ile Ala Leu Asp Glu Ala Met Ala Asn 
        355                 360                 365             

Ala Lys Ala Leu Leu Ala Ala Ala Ala Glu Asn Ala Val Arg Ala Trp 
    370                 375                 380                 

Leu Ala Gly Arg Pro 
385                 

<210>   733
<211>   1170
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   733
gtgacgcacg tgacatccat cggcgcgaaa ggtgaagctc cccacatcct gctcgccccc       60

gattccttca agggctcgct caccgcgcgc gaggcggctg aggcgatggc cgagggcgtg      120

agccgggcgt gtccatccgc ccagttggcg cttgtcccca tcgcggacgg cggcgaaggc      180

acgcttgcgg ccatcgccac ctcgacccgc gcgcggtggc tatcgaccga ggttacggcg      240

gcgagcggcc aacctaagca aggccgtttc cttgccctcc ccgatggcac cgccgtcgtc      300

gagtgcgcgg aggccgtcgg cctgccggag gccctccgtt cgggcgcgga cgtctggcgc      360

cggaccacgg tcggggtcgg cgagatgatc cggcacgcgc tcgagacggg gcatcgccgc      420

atcgcggtgg cgctcggggg atccgccacg aacgacgcgg gcgtcggcat gctcgcggcg      480

ctcggtgtgc gattactcga tgatgcgggc caggacgtgc ccccggtgcc ggcggagttt      540

caccgcgtgg cgcgcgtcga cgtgtctggc ctcgacgagc gcctccgcgg cgccgagatg      600

ctcgccgtgt gcgacgtgga taacccgctc acgggcgaaa acggggccac caccgtcttc      660

ggcccgcaga agggcgtctc gacccacgac gtgccgcgtc tagacgaggc gctcgcgcac      720

ctggccgcgc gctgcgaggc ggcctttggc tgcaaagcgg cggacctgcc cggcgcaggc      780

gcggcggggg gccttggctt cgcgctctac cttcttggcg ccgcgcgggt gtccggcatc      840

gactttgtgc tggacgcggt cgggttcgat cacgcccttg aacgtgccgc gctcgtcctc      900

accggcgaag gccgcacgga tgcgcagacg gcccacggca aggcggtggc tggcgtggcc      960

cggcgcgcca aagcccgcgg cgtgcctgtg ttctgcatct ccggggccat cggcccgggg     1020

gccgagcgcc tgtacgatca cggcgtctcc gcgctcttcg ccaccgcgcc cgggcccatc     1080

gcgctggacg aggccatggc gaacgccaag gcgctgcttg cggctgctgc ggaaaacgcc     1140

gtgcgtgcgt ggctcgctgg acggccttag                                      1170


<210>   734
<211>   351
<212>   PRT
<213>   Pelobacter propionicus DSM 2379

<400>   734
Ile Ile Ile Ala Pro Asp Ser Tyr Lys Gly Ser Leu Ser Ala Val Glu 
                5                   10                  15      

Val Ala Glu Ala Met Ala Arg Gly Ile Val Ser Val Phe Pro Asp Ala 
            20                  25                  30          

Glu Ile Val Ser Leu Pro Val Ala Asp Gly Gly Glu Gly Thr Val Glu 
        35                  40                  45              

Ala Leu Val Ala Ala Thr Ser Gly Arg Phe Val Cys Gln Glu Val Ser 
    50                  55                  60                  

Gly Pro Leu Gly Glu Pro Val Met Ala Arg Trp Gly Ile Leu Gly Asp 
65                  70                  75                  80  

Gly Ala Thr Ala Val Ile Glu Met Ala Ala Ala Ser Gly Leu Pro Leu 
                85                  90                  95      

Val Ala Pro Glu Arg Arg Asn Pro Leu Arg Ala Ser Thr Cys Gly Thr 
            100                 105                 110         

Gly Glu Leu Ile Arg Ala Ala Leu Asp Ala Gly Leu Arg Arg Leu Ile 
        115                 120                 125             

Val Gly Ile Gly Gly Ser Ala Thr Asn Asp Gly Gly Ala Gly Met Ala 
    130                 135                 140                 

Arg Ala Leu Gly Val Arg Phe Leu Asp Ala Asp Gly Thr Glu Leu Pro 
145                 150                 155                 160 

Glu Gly Gly Ala Ala Leu Ala Arg Leu Ala Arg Val Asp Leu Asp Gly 
                165                 170                 175     

Leu Asp Pro Arg Leu Val Glu Thr Ser Leu Gln Val Ala Cys Asp Val 
            180                 185                 190         

Thr Asn Pro Leu Cys Gly Glu Asn Gly Ala Ser Val Ile Tyr Gly Pro 
        195                 200                 205             

Gln Lys Gly Ala Thr Pro Glu Met Val Arg Glu Leu Asp Arg Ala Leu 
    210                 215                 220                 

Glu His Tyr Ser Gln Val Val Glu Gln Ala Ile Ala Arg Asn Val Ser 
225                 230                 235                 240 

Asp Gln Ala Gly Ser Gly Ala Ala Gly Gly Leu Gly Ala Gly Leu Arg 
                245                 250                 255     

Tyr Phe Thr Asn Ala Ser Leu Leu Pro Gly Val Lys Ile Val Leu Asp 
            260                 265                 270         

Ala Val Gly Phe Ala Glu Ala Leu Lys Thr Ala Asp Leu Val Ile Thr 
        275                 280                 285             

Gly Glu Gly Cys Ser Asp Ala Gln Thr Ala His Gly Lys Ala Pro Leu 
    290                 295                 300                 

Gly Val Ala Arg Leu Ala Arg Asn Gly Gly Val Pro Val Ile Cys Leu 
305                 310                 315                 320 

Ser Gly Gly Leu Gly Ala Gly Ala Glu Gln Leu Leu Glu His Gly Ile 
                325                 330                 335     

Asp Ala Leu Leu Gly Ile Val Ser Cys Pro Met Pro Leu Glu Asp 
            340                 345                 350     

<210>   735
<211>   351
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   735
Ile Ile Val Ala Pro Asp Ser Phe Lys Gly Ser Leu Thr Ala Leu Lys 
                5                   10                  15      

Ala Ala Glu Ala Met Arg Gln Gly Val Leu Asp Ala Met Pro Asp Ala 
            20                  25                  30          

Glu Val Val Ala Leu Pro Met Ala Asp Gly Gly Glu Gly Thr Thr Gln 
        35                  40                  45              

Ala Leu Val Ala Ala Thr Gly Gly Gln Leu Val Glu Ala Glu Val Thr 
    50                  55                  60                  

Gly Pro Leu Gly Glu Pro Val Arg Ala Ala Phe Gly Leu Leu Gly Asp 
65                  70                  75                  80  

Gly Asp Thr Ala Val Ile Glu Met Ala Ala Ala Ser Gly Leu Leu Leu 
                85                  90                  95      

Val Pro Pro Glu Arg Arg Asp Pro Lys Val Thr Thr Thr Tyr Gly Thr 
            100                 105                 110         

Gly Glu Leu Ile Arg Ala Ala Leu Asp Arg Gly Val Arg Arg Ile Leu 
        115                 120                 125             

Val Gly Ile Gly Gly Ser Ala Thr Asn Asp Gly Gly Val Gly Met Ala 
    130                 135                 140                 

Gln Ala Leu Gly Gly Arg Phe Leu Lys Ala Asp Gly Ser Pro Val Asp 
145                 150                 155                 160 

Arg Gly Gly Ala Ala Leu Leu Glu Leu Glu Arg Ile Asp Leu Ser Gly 
                165                 170                 175     

Leu Asp Pro Arg Leu Lys Gly Val Glu Leu Met Val Ala Cys Asp Val 
            180                 185                 190         

Asp Asn Pro Leu Thr Gly Pro Arg Gly Ala Ala Ala Val Tyr Gly Pro 
        195                 200                 205             

Gln Lys Gly Ala Thr Ala Glu Asp Val Ala Leu Leu Asp Arg Ala Leu 
    210                 215                 220                 

Thr Arg Leu Ala Asp Val Met Val Arg Asp Leu Gly Arg Asp Val Arg 
225                 230                 235                 240 

Asn Leu Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Ala Gly Leu Met 
                245                 250                 255     

Gly Phe Leu Gly Ala Arg Leu Arg Pro Gly Ile Asp Val Val Met Glu 
            260                 265                 270         

Val Thr Gly Leu Arg Arg Gln Leu Gln Gly Ala Ala Leu Leu Leu Thr 
        275                 280                 285             

Gly Glu Gly Arg Thr Asp Gly Gln Thr Leu Ala Gly Lys Val Pro Leu 
    290                 295                 300                 

Gly Leu Ala Arg Ala Ala Ala Pro Cys Gly Val Pro Val Val Val Ile 
305                 310                 315                 320 

Ser Gly Ala Val Thr Asp Asp Ala Asp Ala Leu Leu Glu Gln Gly Val 
                325                 330                 335     

Ala Ala Leu Leu Ser Thr Ala Pro Gly Pro Val Thr Leu Asp Glu 
            340                 345                 350     

<210>   736
<211>   350
<212>   PRT
<213>   Bordetella petrii

<400>   736
Ile Ile Ile Ala Pro Asp Ser Phe Lys Glu Ser Leu Ser Ala Pro Asp 
                5                   10                  15      

Ala Ala Ala Ala Ile Glu Arg Gly Val Lys Gln Ala Phe Pro Gly Ala 
            20                  25                  30          

Arg Thr Leu Cys Val Pro Met Ala Asp Gly Gly Glu Gly Thr Val Ala 
        35                  40                  45              

Ala Val Leu Ala Ala Thr Gly Gly Gln Trp Arg Thr Thr Pro Val Ser 
    50                  55                  60                  

Gly Ala Leu Gly Glu Pro Met Gln Ala Ala Trp Gly Trp Leu Asp Asp 
65                  70                  75                  80  

Ser Thr Ala Val Ile Glu Met Ala Ala Ala Ala Gly Leu Glu Gln Thr 
                85                  90                  95      

Pro Pro Glu Arg Arg Asp Pro Leu Arg Ala Ser Ser Gly Gly Val Gly 
            100                 105                 110         

Glu Leu Leu Arg Ala Ala Leu Asp Ala Gly Ala Arg Arg Ile Ile Leu 
        115                 120                 125             

Gly Leu Gly Gly Ser Ala Thr Asn Asp Gly Gly Ala Gly Met Leu Ala 
    130                 135                 140                 

Ala Leu Gly Val Arg Phe Leu Asp Ala Asn Gly Leu Asp Leu Pro Pro 
145                 150                 155                 160 

Gly Gly Ala Ala Leu Gln Gln Leu Ala Arg Ile Asp Val Gln Gly Leu 
                165                 170                 175     

Asp Pro Arg Leu Ala Gly Val Gln Ile Asp Ile Ala Ser Asp Val Asp 
            180                 185                 190         

Asn Pro Leu Cys Gly Pro Gln Gly Ala Ser His Thr Phe Gly Pro Gln 
        195                 200                 205             

Lys Gly Ala Ser Pro Glu Gln Val Ala Leu Leu Asp Arg Ser Leu Ala 
    210                 215                 220                 

Arg Leu Ala Asp Val Cys Ala Arg Asp Leu Gly Arg Asp Met Arg Asp 
225                 230                 235                 240 

Ala Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Tyr Ala Ala His Ala 
                245                 250                 255     

Phe Leu Asn Ala Arg Phe Arg Pro Gly Val Glu Leu Val Ala Glu Leu 
            260                 265                 270         

Gly Lys Leu Ala Gln Ala Met Glu Gly Ala Ala Leu Ala Phe Thr Gly 
        275                 280                 285             

Glu Gly Arg Met Asp Ala Gln Thr Leu Arg Gly Lys Thr Pro Ala Gly 
    290                 295                 300                 

Val Ala Arg Ile Ala Arg Arg Ala Gly Val Pro Val Val Ala Leu Ala 
305                 310                 315                 320 

Gly Ser Leu Gly Glu Gly Tyr Gln Asp Leu His Ala Gly Gly Ile Thr 
                325                 330                 335     

Ala Ala Phe Ser Leu Ala Pro Gly Pro Val Ser Leu Gln Gln 
            340                 345                 350 

<210>   737
<211>   351
<212>   PRT
<213>   Thermosinus carboxydivorans Nor1

<400>   737
Val Val Ile Ala Pro Asp Ser Phe Lys Gly Ser Val Ser Ala Leu Gly 
                5                   10                  15      

Val Ala Asn Ala Val Ala Asn Gly Val Arg Ala Val Phe Pro Asp Ala 
            20                  25                  30          

Glu Ile Ile Lys Val Pro Ile Ala Asp Gly Gly Glu Gly Thr Val Glu 
        35                  40                  45              

Ala Leu Val Thr Ala Thr Gly Gly Gln Ile Val Thr Arg Glu Val Val 
    50                  55                  60                  

Gly Pro Leu Gly Glu Pro Val Met Ala His Trp Gly Val Leu Gly Asp 
65                  70                  75                  80  

Gly Asp Thr Ala Val Ile Glu Met Ala Ala Ala Ser Gly Leu Thr Leu 
                85                  90                  95      

Val Pro Lys Glu Lys Arg Asp Pro Arg Ile Thr Thr Thr Tyr Gly Thr 
            100                 105                 110         

Gly Gln Leu Ile Lys Ala Val Leu Asp Arg Gly Ile Arg Lys Ile Ile 
        115                 120                 125             

Ile Gly Ile Gly Gly Ser Ala Thr Asn Asp Gly Gly Thr Gly Met Ala 
    130                 135                 140                 

Lys Ala Leu Gly Ala Arg Phe Leu Asp Ala Ser Gly Gln Glu Leu Pro 
145                 150                 155                 160 

Pro Gly Gly Ala Ala Leu Ala Arg Leu Ala Lys Ile Asp Leu Ser Gly 
                165                 170                 175     

Leu Asp Glu Arg Leu Arg Thr Thr Thr Ile Leu Val Ala Cys Asp Val 
            180                 185                 190         

Asp Asn Pro Leu Cys Gly Pro Arg Gly Ala Ser Ala Val Tyr Gly Pro 
        195                 200                 205             

Gln Lys Gly Ala Thr Pro Glu Met Val Lys Glu Leu Asp Ala Ala Leu 
    210                 215                 220                 

Lys Asn Phe Ala Ala Val Ala Thr Val Ala Thr Gly Lys Asp Val Ala 
225                 230                 235                 240 

Asp Tyr Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Ala Gly Leu Leu 
                245                 250                 255     

Phe Phe Thr Gly Ala Gln Leu Arg Pro Gly Val Glu Ile Val Leu Glu 
            260                 265                 270         

Thr Thr Gly Phe Ala Ser Leu Val Ala Thr Ala Asp Leu Val Ile Thr 
        275                 280                 285             

Gly Glu Gly Arg Thr Asp Phe Gln Thr Ala Tyr Gly Lys Ala Pro Val 
    290                 295                 300                 

Gly Val Ala Lys Val Ala Lys Gln Tyr Gly Val Pro Val Val Cys Leu 
305                 310                 315                 320 

Ser Gly Gly Leu Gly Asp Gly Ala Asp Asp Val Leu Ala Gln Gly Val 
                325                 330                 335     

Asp Ala Leu Met Ser Val Val Pro Gln Pro Met Ala Leu Asp Glu 
            340                 345                 350     

<210>   738
<211>   350
<212>   PRT
<213>   Moorella thermoacetica ATCC 39073

<400>   738
Ile Val Ile Ala Pro Asp Ser Phe Lys Glu Ser Leu Ser Ala Pro Glu 
                5                   10                  15      

Val Ala Ala Ala Ile Ala Gln Gly Ile His Arg Val Leu Pro Glu Val 
            20                  25                  30          

Glu Thr Val Asn Val Pro Met Ala Asp Gly Gly Glu Gly Leu Thr Ala 
        35                  40                  45              

Thr Leu Val Ala Ala Thr Gly Gly Arg Glu Met Thr Ala Thr Val Thr 
    50                  55                  60                  

Gly Pro Leu Gly Glu Pro Val Gln Ala Ser Trp Gly Ile Leu Gly Asp 
65                  70                  75                  80  

Gly Ile Thr Ala Val Val Glu Met Ala Gln Ala Ser Gly Leu Pro Leu 
                85                  90                  95      

Val Pro Arg Glu Lys Arg Asn Pro Leu Val Thr Thr Thr Tyr Gly Thr 
            100                 105                 110         

Gly Glu Leu Ile His Gln Ala Leu Glu Ala Gly Cys Arg Arg Leu Ile 
        115                 120                 125             

Val Gly Ile Gly Gly Ser Ala Thr Asn Asp Gly Gly Ala Gly Met Ala 
    130                 135                 140                 

Arg Ala Leu Gly Val Lys Leu Leu Asp Ala Glu Gly Ala Asp Ile Pro 
145                 150                 155                 160 

Pro Gly Ala Gly Gly Leu Glu Arg Leu Glu Arg Ile Asp Ile Gln Gly 
                165                 170                 175     

Leu Asp Pro Arg Val Lys Glu Val Glu Ile Leu Val Ala Cys Asp Val 
            180                 185                 190         

Asp Asn Pro Leu Cys Gly Pro Arg Gly Ala Ser Ala Val Tyr Gly Pro 
        195                 200                 205             

Gln Lys Gly Ala Thr Pro Glu Met Ile Pro Arg Leu Asp Ala Ala Leu 
    210                 215                 220                 

Ala Arg Leu Ala Asp Ile Val Ala Arg Asp Leu Lys Val Asp Val Arg 
225                 230                 235                 240 

Glu Leu Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Ala Gly Leu Val 
                245                 250                 255     

Ala Phe Leu Gly Ala Thr Leu Arg Arg Gly Ile Glu Leu Val Ile Glu 
            260                 265                 270         

Ala Val Asn Leu Asp Gly Ile Leu Ala Ala Gly Ala Asp Leu Val Ile 
        275                 280                 285             

Thr Gly Glu Gly Glu Ile Asn Arg Gln Thr Ala Tyr Gly Lys Val Pro 
    290                 295                 300                 

Ala Gly Val Ala Gly Val Ala Ala Lys Tyr Gly Ile Pro Val Val Ala 
305                 310                 315                 320 

Leu Val Gly Ser Ile Gly Glu Gly Ala Ser Ala Val Tyr Asp His Gly 
                325                 330                 335     

Ile Gln Gly Phe Met Ser Ile Val Pro Arg Pro Val Pro Leu 
            340                 345                 350 

<210>   739
<211>   389
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   739
Met Thr His Val Thr Ser Ile Gly Ala Lys Gly Glu Ala Pro His Ile 
                5                   10                  15      

Leu Leu Ala Pro Asp Ser Phe Lys Gly Ser Leu Thr Ala Arg Glu Ala 
            20                  25                  30          

Ala Glu Ala Met Ala Glu Gly Val Ser Lys Ala Cys Pro Ser Ala Gln 
        35                  40                  45              

Leu Ala Leu Val Pro Ile Ala Asp Gly Gly Glu Gly Thr Leu Ala Ala 
    50                  55                  60                  

Ile Ala Thr Ser Thr Arg Ala Arg Trp Leu Ser Thr Glu Val Thr Ala 
65                  70                  75                  80  

Ala Ser Gly Gln Pro Lys Gln Gly Arg Phe Leu Ala Leu Pro Asp Gly 
                85                  90                  95      

Thr Ala Val Val Glu Cys Ala Glu Ala Val Gly Leu Pro Glu Ala Leu 
            100                 105                 110         

Arg Ser Gly Ala Asp Val Trp Arg Arg Thr Thr Val Gly Val Gly Glu 
        115                 120                 125             

Met Ile Arg His Ala Leu Glu Thr Gly His Arg Arg Ile Ala Val Ala 
    130                 135                 140                 

Leu Gly Gly Ser Ala Thr Asn Asp Ala Gly Val Gly Met Leu Ala Ala 
145                 150                 155                 160 

Leu Gly Val Arg Leu Leu Asp Asp Ala Gly Gln Asp Val Pro Pro Val 
                165                 170                 175     

Pro Ala Glu Phe His Arg Val Ala Arg Val Asp Val Ser Gly Leu Asp 
            180                 185                 190         

Glu Arg Leu Arg Gly Ala Glu Met Leu Ala Val Cys Asp Val Asp Asn 
        195                 200                 205             

Pro Leu Thr Gly Glu Asn Gly Ala Thr Thr Val Phe Gly Pro Gln Lys 
    210                 215                 220                 

Gly Val Ser Thr His Asp Val Pro Arg Leu Asp Glu Ala Leu Ala His 
225                 230                 235                 240 

Leu Ala Ala Arg Cys Glu Ala Ala Phe Gly Cys Lys Ala Ala Asp Leu 
                245                 250                 255     

Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Phe Ala Leu Tyr Leu Leu 
            260                 265                 270         

Gly Ala Ala Arg Val Ser Gly Ile Asp Phe Val Leu Asp Ala Val Gly 
        275                 280                 285             

Phe Asp His Ala Leu Glu Arg Ala Ala Leu Val Leu Thr Gly Glu Gly 
    290                 295                 300                 

Arg Thr Asp Ala Gln Thr Ala His Gly Lys Ala Val Ala Gly Val Ala 
305                 310                 315                 320 

Arg Arg Ala Lys Ala Arg Gly Val Pro Val Phe Cys Ile Ser Gly Ala 
                325                 330                 335     

Ile Gly Pro Gly Ala Glu Arg Leu Tyr Asp His Gly Val Ser Ala Leu 
            340                 345                 350         

Phe Ala Thr Ala Pro Gly Pro Ile Ala Leu Asp Glu Ala Met Ala Asn 
        355                 360                 365             

Ala Lys Ala Leu Leu Ala Ala Ala Ala Glu Asn Ala Val Arg Ala Trp 
    370                 375                 380                 

Leu Ala Gly Arg Pro 
385                 

<210>   740
<211>   389
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   740
Met Thr His Val Thr Ser Ile Gly Ala Lys Gly Glu Ala Pro His Ile 
                5                   10                  15      

Leu Leu Ala Pro Asp Ser Phe Lys Gly Ser Leu Thr Ala Arg Glu Ala 
            20                  25                  30          

Ala Glu Ala Met Ala Glu Gly Val Ser Arg Ala Cys Pro Ser Ala Gln 
        35                  40                  45              

Leu Ala Leu Val Pro Ile Ala Asp Gly Gly Glu Gly Thr Leu Ala Ala 
    50                  55                  60                  

Ile Ala Thr Ser Thr Arg Ala Arg Trp Leu Ser Thr Glu Val Thr Ala 
65                  70                  75                  80  

Ala Ser Gly Gln Pro Lys Gln Gly Arg Phe Leu Ala Leu Pro Asp Gly 
                85                  90                  95      

Thr Ala Val Val Glu Cys Ala Glu Ala Val Gly Leu Pro Glu Ala Leu 
            100                 105                 110         

Arg Ser Gly Ala Asp Val Trp Arg Arg Thr Thr Val Gly Val Gly Glu 
        115                 120                 125             

Met Ile Arg His Ala Leu Glu Thr Gly His Arg Arg Ile Ala Val Ala 
    130                 135                 140                 

Leu Gly Gly Ser Ala Thr Asn Asp Ala Gly Val Gly Met Leu Ala Ala 
145                 150                 155                 160 

Leu Gly Val Arg Leu Leu Asp Asp Ala Gly Gln Asp Val Pro Pro Val 
                165                 170                 175     

Pro Ala Glu Phe His Arg Val Ala Arg Val Asp Val Ser Gly Leu Asp 
            180                 185                 190         

Glu Arg Leu Arg Gly Ala Glu Met Leu Ala Val Cys Asp Val Asp Asn 
        195                 200                 205             

Pro Leu Thr Gly Glu Asn Gly Ala Thr Thr Val Phe Gly Pro Gln Lys 
    210                 215                 220                 

Gly Val Ser Thr His Asp Val Pro Arg Leu Asp Glu Ala Leu Ala His 
225                 230                 235                 240 

Leu Ala Ala Arg Cys Glu Ala Ala Phe Gly Cys Lys Ala Ala Asp Leu 
                245                 250                 255     

Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Phe Ala Leu Tyr Leu Leu 
            260                 265                 270         

Gly Ala Ala Arg Val Ser Gly Ile Asp Phe Val Leu Asp Ala Val Gly 
        275                 280                 285             

Phe Asp His Ala Leu Glu Arg Ala Ala Leu Val Leu Thr Gly Glu Gly 
    290                 295                 300                 

Lys Thr Asp Ala Gln Thr Ala His Gly Lys Ala Val Ala Gly Val Ala 
305                 310                 315                 320 

Arg Arg Ala Lys Ala Arg Gly Val Pro Val Phe Cys Ile Ser Gly Ala 
                325                 330                 335     

Ile Gly Pro Gly Ala Glu Arg Leu Tyr Asp His Gly Val Ser Ala Leu 
            340                 345                 350         

Phe Ala Thr Ala Pro Gly Pro Ile Ala Leu Asp Glu Ala Met Ala Asn 
        355                 360                 365             

Ala Lys Ala Leu Leu Ala Ala Ala Ala Glu Asn Ala Val Arg Ala Trp 
    370                 375                 380                 

Leu Ala Gly Arg Pro 
385                 

<210>   741
<211>   389
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   741
Met Thr His Val Thr Ser Ile Gly Ala Lys Gly Glu Ala Pro His Ile 
                5                   10                  15      

Leu Leu Ala Pro Asp Ser Phe Lys Gly Ser Leu Thr Ala Arg Glu Ala 
            20                  25                  30          

Ala Glu Ala Met Ala Glu Gly Val Ser Arg Ala Cys Pro Ser Ala Gln 
        35                  40                  45              

Leu Ala Leu Val Pro Ile Ala Asp Gly Gly Glu Gly Thr Leu Ala Ala 
    50                  55                  60                  

Ile Ala Thr Ser Thr Arg Ala Arg Trp Leu Ser Thr Glu Val Thr Ala 
65                  70                  75                  80  

Ala Ser Gly Gln Pro Lys Gln Gly Arg Phe Leu Ala Leu Pro Asp Gly 
                85                  90                  95      

Thr Ala Val Val Glu Cys Ala Glu Ala Val Gly Leu Pro Glu Ala Leu 
            100                 105                 110         

Arg Ser Gly Ala Asp Val Trp Arg Arg Thr Thr Val Gly Val Gly Glu 
        115                 120                 125             

Met Ile Arg His Ala Leu Glu Thr Gly His Arg Arg Ile Ala Val Ala 
    130                 135                 140                 

Leu Gly Gly Ser Ala Thr Asn Asp Ala Gly Val Gly Met Leu Ala Ala 
145                 150                 155                 160 

Leu Gly Val Arg Leu Leu Asp Asp Ala Gly Gln Asp Val Pro Pro Val 
                165                 170                 175     

Pro Ala Glu Phe His Arg Val Ala Arg Val Asp Val Ser Gly Leu Asp 
            180                 185                 190         

Glu Arg Leu Arg Gly Ala Glu Met Leu Ala Val Cys Asp Val Asp Asn 
        195                 200                 205             

Pro Leu Thr Gly Glu Asn Gly Ala Thr Thr Val Phe Gly Pro Gln Lys 
    210                 215                 220                 

Gly Val Ser Thr His Asp Val Pro Arg Leu Asp Glu Ala Leu Ala His 
225                 230                 235                 240 

Leu Ala Ala Arg Cys Glu Ala Ala Phe Gly Cys Lys Ala Ala Asp Leu 
                245                 250                 255     

Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Phe Ala Leu Tyr Leu Leu 
            260                 265                 270         

Gly Ala Ala Arg Val Ser Gly Ile Asp Phe Val Leu Asp Ala Val Gly 
        275                 280                 285             

Phe Asp His Ala Leu Glu Arg Ala Ala Leu Val Leu Thr Gly Glu Gly 
    290                 295                 300                 

Arg Thr Asp Ala Gln Thr Ala His Gly Lys Ala Val Ala Gly Val Ala 
305                 310                 315                 320 

Arg Arg Ala Lys Ala Arg Gly Val Pro Val Phe Cys Ile Ser Gly Ala 
                325                 330                 335     

Ile Gly Pro Gly Ala Glu Arg Leu Tyr Asp His Gly Val Ser Ala Leu 
            340                 345                 350         

Phe Ala Thr Ala Pro Gly Pro Ile Ala Leu Asp Glu Ala Met Ala Asn 
        355                 360                 365             

Ala Lys Ala Leu Leu Ala Ala Ala Ala Glu Gln Ala Val Arg Ala Trp 
    370                 375                 380                 

Leu Ala Gly Arg Pro 
385                 

<210>   742
<211>   389
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   742
Met Thr His Val Thr Ser Ile Gly Ala Lys Gly Glu Ala Pro His Ile 
                5                   10                  15      

Leu Leu Ala Pro Asp Ser Phe Lys Gly Ser Leu Thr Ala Arg Glu Ala 
            20                  25                  30          

Ala Glu Ala Met Ala Glu Gly Val Ser Arg Ala Cys Pro Ser Ala Gln 
        35                  40                  45              

Leu Ala Leu Val Pro Ile Ala Asp Gly Gly Glu Gly Thr Leu Ala Ala 
    50                  55                  60                  

Ile Ala Thr Ser Thr Arg Ala Arg Trp Leu Ser Thr Glu Val Thr Ala 
65                  70                  75                  80  

Ala Ser Gly Gln Pro Lys Gln Gly Arg Phe Leu Ala Leu Pro Asp Gly 
                85                  90                  95      

Thr Ala Val Val Glu Cys Ala Glu Ala Val Gly Leu Pro Glu Ala Leu 
            100                 105                 110         

Arg Ser Gly Ala Asp Val Trp Arg Arg Thr Thr Val Gly Val Gly Glu 
        115                 120                 125             

Met Ile Arg His Ala Leu Glu Thr Gly His Arg Arg Ile Ala Val Ala 
    130                 135                 140                 

Leu Gly Gly Ser Ala Thr Asn Asp Ala Gly Val Gly Met Leu Ala Ala 
145                 150                 155                 160 

Leu Gly Val Arg Leu Leu Asp Asp Ala Gly Gln Asp Val Pro Pro Val 
                165                 170                 175     

Pro Ala Glu Phe His Arg Val Ala Arg Val Asp Val Ser Gly Leu Asp 
            180                 185                 190         

Glu Arg Leu Arg Gly Ala Glu Met Leu Ala Val Cys Asp Val Glu Asn 
        195                 200                 205             

Pro Leu Thr Gly Glu Asn Gly Ala Thr Thr Val Phe Gly Pro Gln Lys 
    210                 215                 220                 

Gly Val Ser Thr His Asp Val Pro Arg Leu Asp Glu Ala Leu Ala His 
225                 230                 235                 240 

Leu Ala Ala Arg Cys Glu Ala Ala Phe Gly Cys Lys Ala Ala Asp Leu 
                245                 250                 255     

Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Phe Ala Leu Tyr Leu Leu 
            260                 265                 270         

Gly Ala Ala Arg Val Ser Gly Ile Asp Phe Val Leu Asp Ala Val Gly 
        275                 280                 285             

Phe Asp His Ala Leu Glu Arg Ala Ala Leu Val Leu Thr Gly Glu Gly 
    290                 295                 300                 

Arg Thr Asp Ala Gln Thr Ala His Gly Lys Ala Val Ala Gly Val Ala 
305                 310                 315                 320 

Arg Arg Ala Lys Ala Arg Gly Val Pro Val Phe Cys Ile Ser Gly Ala 
                325                 330                 335     

Ile Gly Pro Gly Ala Glu Arg Leu Tyr Asp His Gly Val Ser Ala Leu 
            340                 345                 350         

Phe Ala Thr Ala Pro Gly Pro Ile Ala Leu Asp Glu Ala Met Ala Asn 
        355                 360                 365             

Ala Lys Ala Leu Leu Ala Ala Ala Ala Glu Asn Ala Val Arg Ala Trp 
    370                 375                 380                 

Leu Ala Gly Arg Pro 
385                 

<210>   743
<211>   389
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   743
Met Thr His Val Thr Ser Ile Gly Ala Lys Gly Glu Ala Pro His Ile 
                5                   10                  15      

Leu Leu Ala Pro Asp Ser Phe Lys Gly Ser Leu Thr Ala Arg Glu Ala 
            20                  25                  30          

Ala Glu Ala Met Ala Glu Gly Val Ser Arg Ala Cys Pro Ser Ala Gln 
        35                  40                  45              

Leu Ala Leu Val Pro Ile Ala Asp Gly Gly Glu Gly Thr Leu Ala Ala 
    50                  55                  60                  

Ile Ala Thr Ser Thr Arg Ala Arg Trp Leu Ser Thr Glu Val Thr Ala 
65                  70                  75                  80  

Ala Ser Gly Gln Pro Lys Gln Gly Arg Phe Leu Ala Leu Pro Asp Gly 
                85                  90                  95      

Thr Ala Val Val Glu Cys Ala Glu Ala Ile Gly Leu Pro Glu Ala Leu 
            100                 105                 110         

Arg Ser Gly Ala Asp Val Trp Arg Arg Thr Thr Val Gly Val Gly Glu 
        115                 120                 125             

Met Ile Arg His Ala Leu Glu Thr Gly His Arg Arg Ile Ala Val Ala 
    130                 135                 140                 

Leu Gly Gly Ser Ala Thr Asn Asp Ala Gly Val Gly Met Leu Ala Ala 
145                 150                 155                 160 

Leu Gly Val Arg Leu Leu Asp Asp Ala Gly Gln Asp Val Pro Pro Val 
                165                 170                 175     

Pro Ala Glu Phe His Arg Val Ala Arg Val Asp Val Ser Gly Leu Asp 
            180                 185                 190         

Glu Arg Leu Arg Gly Ala Glu Met Leu Ala Val Cys Asp Val Asp Asn 
        195                 200                 205             

Pro Leu Thr Gly Glu Asn Gly Ala Thr Thr Val Phe Gly Pro Gln Lys 
    210                 215                 220                 

Gly Val Ser Thr His Asp Val Pro Arg Leu Asp Glu Ala Leu Ala His 
225                 230                 235                 240 

Leu Ala Ala Arg Cys Glu Ala Ala Phe Gly Cys Lys Ala Ala Asp Leu 
                245                 250                 255     

Pro Gly Ala Gly Ala Ala Gly Gly Leu Gly Phe Ala Leu Tyr Leu Leu 
            260                 265                 270         

Gly Ala Ala Arg Val Ser Gly Ile Asp Phe Val Leu Asp Ala Val Gly 
        275                 280                 285             

Phe Asp His Ala Leu Glu Arg Ala Ala Leu Val Leu Thr Gly Glu Gly 
    290                 295                 300                 

Arg Thr Asp Ala Gln Thr Ala His Gly Lys Ala Val Ala Gly Val Ala 
305                 310                 315                 320 

Arg Arg Ala Lys Ala Arg Gly Val Pro Val Phe Cys Ile Ser Gly Ala 
                325                 330                 335     

Ile Gly Pro Gly Ala Glu Arg Leu Tyr Asp His Gly Val Ser Ala Leu 
            340                 345                 350         

Phe Ala Thr Ala Pro Gly Pro Ile Ala Leu Asp Glu Ala Met Ala Asn 
        355                 360                 365             

Ala Lys Ala Leu Leu Ala Ala Ala Ala Glu Asn Ala Val Arg Ala Trp 
    370                 375                 380                 

Leu Ala Gly Arg Pro 
385                 

<210>   744
<211>   1170
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   744
gtgacgcacg tgacatccat cggcgcgaaa ggtgaagctc cccacatcct gctcgccccc       60

gattccttca agggctcgct caccgcgcgc gaggcggctg aggcgatggc cgagggcgtg      120

agcaaagcgt gtccatccgc ccagttggcg cttgtcccca tcgcggacgg cggcgaaggc      180

acgcttgcgg ccatcgccac ctcgacccgc gcgcggtggc tatcgaccga ggttacggcg      240

gcgagcggcc aacctaagca aggccgtttc cttgccctcc ccgatggcac cgccgtcgtc      300

gagtgcgcgg aggccgtcgg cctgccggag gccctccgtt cgggcgcgga cgtctggcgc      360

cggaccacgg tcggggtcgg cgagatgatc cggcacgcgc tcgagacggg gcatcgccgc      420

atcgcggtgg cgctcggggg atccgccacg aacgacgcgg gcgtcggcat gctcgcggcg      480

ctcggtgtgc gattactcga tgatgcgggc caggacgtgc ccccggtgcc ggcggagttt      540

caccgcgtgg cgcgcgtcga cgtgtctggc ctcgacgagc gcctccgcgg cgccgagatg      600

ctcgccgtgt gcgacgtgga taacccgctc acgggcgaaa acggggccac caccgtcttc      660

ggcccgcaga agggcgtctc gacccacgac gtgccgcgtc tagacgaggc gctcgcgcac      720

ctggccgcgc gctgcgaggc ggcctttggc tgcaaagcgg cggacctgcc cggcgcaggc      780

gcggcggggg gccttggctt cgcgctctac cttcttggcg ccgcgcgggt gtccggcatc      840

gactttgtgc tggacgcggt cgggttcgat cacgcccttg aacgtgccgc gctcgtcctc      900

accggcgaag gccgcacgga tgcgcagacg gcccacggca aggcggtggc tggcgtggcc      960

cggcgcgcca aagcccgcgg cgtgcctgtg ttctgcatct ccggggccat cggcccgggg     1020

gccgagcgcc tgtacgatca cggcgtctcc gcgctcttcg ccaccgcgcc cgggcccatc     1080

gcgctggacg aggccatggc gaacgccaag gcgctgcttg cggctgctgc ggaaaacgcc     1140

gtgcgtgcgt ggctcgctgg acggccttag                                      1170


<210>   745
<211>   1170
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   745
gtgacgcacg tgacatccat cggcgcgaaa ggtgaagctc cccacatcct gctcgccccc       60

gattccttca agggctcgct caccgcgcgc gaggcggctg aggcgatggc cgagggcgtg      120

agccgggcgt gtccatccgc ccagttggcg cttgtcccca tcgcggacgg cggcgaaggc      180

acgcttgcgg ccatcgccac ctcgacccgc gcgcggtggc tatcgaccga ggttacggcg      240

gcgagcggcc aacctaagca aggccgtttc cttgccctcc ccgatggcac cgccgtcgtc      300

gagtgcgcgg aggccgtcgg cctgccggag gccctccgtt cgggcgcgga cgtctggcgc      360

cggaccacgg tcggggtcgg cgagatgatc cggcacgcgc tcgagacggg gcatcgccgc      420

atcgcggtgg cgctcggggg atccgccacg aacgacgcgg gcgtcggcat gctcgcggcg      480

ctcggtgtgc gattactcga tgatgcgggc caggacgtgc ccccggtgcc ggcggagttt      540

caccgcgtgg cgcgcgtcga cgtgtctggc ctcgacgagc gcctccgcgg cgccgagatg      600

ctcgccgtgt gcgacgtgga taacccgctc acgggcgaaa acggggccac caccgtcttc      660

ggcccgcaga agggcgtctc gacccacgac gtgccgcgtc tagacgaggc gctcgcgcac      720

ctggccgcgc gctgcgaggc ggcctttggc tgcaaagcgg cggacctgcc cggcgcaggc      780

gcggcggggg gccttggctt cgcgctctac cttcttggcg ccgcgcgggt gtccggcatc      840

gactttgtgc tggacgcggt cgggttcgat cacgcccttg aacgtgccgc gctcgtcctc      900

accggcgaag gcaaaacgga tgcgcagacg gcccacggca aggcggtggc tggcgtggcc      960

cggcgcgcca aagcccgcgg cgtgcctgtg ttctgcatct ccggggccat cggcccgggg     1020

gccgagcgcc tgtacgatca cggcgtctcc gcgctcttcg ccaccgcgcc cgggcccatc     1080

gcgctggacg aggccatggc gaacgccaag gcgctgcttg cggctgctgc ggaaaacgcc     1140

gtgcgtgcgt ggctcgctgg acggccttag                                      1170


<210>   746
<211>   1170
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   746
gtgacgcacg tgacatccat cggcgcgaaa ggtgaagctc cccacatcct gctcgccccc       60

gattccttca agggctcgct caccgcgcgc gaggcggctg aggcgatggc cgagggcgtg      120

agccgggcgt gtccatccgc ccagttggcg cttgtcccca tcgcggacgg cggcgaaggc      180

acgcttgcgg ccatcgccac ctcgacccgc gcgcggtggc tatcgaccga ggttacggcg      240

gcgagcggcc aacctaagca aggccgtttc cttgccctcc ccgatggcac cgccgtcgtc      300

gagtgcgcgg aggccgtcgg cctgccggag gccctccgtt cgggcgcgga cgtctggcgc      360

cggaccacgg tcggggtcgg cgagatgatc cggcacgcgc tcgagacggg gcatcgccgc      420

atcgcggtgg cgctcggggg atccgccacg aacgacgcgg gcgtcggcat gctcgcggcg      480

ctcggtgtgc gattactcga tgatgcgggc caggacgtgc ccccggtgcc ggcggagttt      540

caccgcgtgg cgcgcgtcga cgtgtctggc ctcgacgagc gcctccgcgg cgccgagatg      600

ctcgccgtgt gcgacgtgga taacccgctc acgggcgaaa acggggccac caccgtcttc      660

ggcccgcaga agggcgtctc gacccacgac gtgccgcgtc tagacgaggc gctcgcgcac      720

ctggccgcgc gctgcgaggc ggcctttggc tgcaaagcgg cggacctgcc cggcgcaggc      780

gcggcggggg gccttggctt cgcgctctac cttcttggcg ccgcgcgggt gtccggcatc      840

gactttgtgc tggacgcggt cgggttcgat cacgcccttg aacgtgccgc gctcgtcctc      900

accggcgaag gccgcacgga tgcgcagacg gcccacggca aggcggtggc tggcgtggcc      960

cggcgcgcca aagcccgcgg cgtgcctgtg ttctgcatct ccggggccat cggcccgggg     1020

gccgagcgcc tgtacgatca cggcgtctcc gcgctcttcg ccaccgcgcc cgggcccatc     1080

gcgctggacg aggccatggc gaacgccaag gcgctgcttg cggctgctgc ggaacaagcc     1140

gtgcgtgcgt ggctcgctgg acggccttag                                      1170


<210>   747
<211>   1170
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   747
gtgacgcacg tgacatccat cggcgcgaaa ggtgaagctc cccacatcct gctcgccccc       60

gattccttca agggctcgct caccgcgcgc gaggcggctg aggcgatggc cgagggcgtg      120

agccgggcgt gtccatccgc ccagttggcg cttgtcccca tcgcggacgg cggcgaaggc      180

acgcttgcgg ccatcgccac ctcgacccgc gcgcggtggc tatcgaccga ggttacggcg      240

gcgagcggcc aacctaagca aggccgtttc cttgccctcc ccgatggcac cgccgtcgtc      300

gagtgcgcgg aggccgtcgg cctgccggag gccctccgtt cgggcgcgga cgtctggcgc      360

cggaccacgg tcggggtcgg cgagatgatc cggcacgcgc tcgagacggg gcatcgccgc      420

atcgcggtgg cgctcggggg atccgccacg aacgacgcgg gcgtcggcat gctcgcggcg      480

ctcggtgtgc gattactcga tgatgcgggc caggacgtgc ccccggtgcc ggcggagttt      540

caccgcgtgg cgcgcgtcga cgtgtctggc ctcgacgagc gcctccgcgg cgccgagatg      600

ctcgccgtgt gcgacgtgga aaacccgctc acgggcgaaa acggggccac caccgtcttc      660

ggcccgcaga agggcgtctc gacccacgac gtgccgcgtc tagacgaggc gctcgcgcac      720

ctggccgcgc gctgcgaggc ggcctttggc tgcaaagcgg cggacctgcc cggcgcaggc      780

gcggcggggg gccttggctt cgcgctctac cttcttggcg ccgcgcgggt gtccggcatc      840

gactttgtgc tggacgcggt cgggttcgat cacgcccttg aacgtgccgc gctcgtcctc      900

accggcgaag gccgcacgga tgcgcagacg gcccacggca aggcggtggc tggcgtggcc      960

cggcgcgcca aagcccgcgg cgtgcctgtg ttctgcatct ccggggccat cggcccgggg     1020

gccgagcgcc tgtacgatca cggcgtctcc gcgctcttcg ccaccgcgcc cgggcccatc     1080

gcgctggacg aggccatggc gaacgccaag gcgctgcttg cggctgctgc ggaaaacgcc     1140

gtgcgtgcgt ggctcgctgg acggccttag                                      1170


<210>   748
<211>   1170
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   748
gtgacgcacg tgacatccat cggcgcgaaa ggtgaagctc cccacatcct gctcgccccc       60

gattccttca agggctcgct caccgcgcgc gaggcggctg aggcgatggc cgagggcgtg      120

agccgggcgt gtccatccgc ccagttggcg cttgtcccca tcgcggacgg cggcgaaggc      180

acgcttgcgg ccatcgccac ctcgacccgc gcgcggtggc tatcgaccga ggttacggcg      240

gcgagcggcc aacctaagca aggccgtttc cttgccctcc ccgatggcac cgccgtcgtc      300

gagtgcgcgg aggccattgg cctgccggag gccctccgtt cgggcgcgga cgtctggcgc      360

cggaccacgg tcggggtcgg cgagatgatc cggcacgcgc tcgagacggg gcatcgccgc      420

atcgcggtgg cgctcggggg atccgccacg aacgacgcgg gcgtcggcat gctcgcggcg      480

ctcggtgtgc gattactcga tgatgcgggc caggacgtgc ccccggtgcc ggcggagttt      540

caccgcgtgg cgcgcgtcga cgtgtctggc ctcgacgagc gcctccgcgg cgccgagatg      600

ctcgccgtgt gcgacgtgga taacccgctc acgggcgaaa acggggccac caccgtcttc      660

ggcccgcaga agggcgtctc gacccacgac gtgccgcgtc tagacgaggc gctcgcgcac      720

ctggccgcgc gctgcgaggc ggcctttggc tgcaaagcgg cggacctgcc cggcgcaggc      780

gcggcggggg gccttggctt cgcgctctac cttcttggcg ccgcgcgggt gtccggcatc      840

gactttgtgc tggacgcggt cgggttcgat cacgcccttg aacgtgccgc gctcgtcctc      900

accggcgaag gccgcacgga tgcgcagacg gcccacggca aggcggtggc tggcgtggcc      960

cggcgcgcca aagcccgcgg cgtgcctgtg ttctgcatct ccggggccat cggcccgggg     1020

gccgagcgcc tgtacgatca cggcgtctcc gcgctcttcg ccaccgcgcc cgggcccatc     1080

gcgctggacg aggccatggc gaacgccaag gcgctgcttg cggctgctgc ggaaaacgcc     1140

gtgcgtgcgt ggctcgctgg acggccttag                                      1170


<210>   749
<211>   148
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   749
Met Leu Thr Val Pro Leu Glu Ile Val Thr Pro Glu Arg Ile Val Leu 
                5                   10                  15      

Ser Met Asp Val Arg Met Val Ile Leu Arg Gly Gly Asp Gly Glu Ile 
            20                  25                  30          

Gly Ile Leu Pro Arg His Met Pro Leu Ala Thr Ala Val Lys Pro Cys 
        35                  40                  45              

Leu Val Arg Ile Arg Leu Ala Asp Asp Arg Gln Asp Val Val Pro Val 
    50                  55                  60                  

Ser Gly Gly Phe Val Glu Val Leu Pro Glu Lys Ile Thr Ile Leu Ala 
65                  70                  75                  80  

Asp Thr Ala Glu Leu Pro Glu Glu Ile Asp Val Asp Arg Ala Leu Arg 
                85                  90                  95      

Ala Lys Asp Arg Ala Glu Lys Arg Leu Gln Ala Ala Val Asp Glu Glu 
            100                 105                 110         

Glu Ala Asp Arg Ala Arg Gln Ala Leu Thr Arg Ala Glu Leu Arg Leu 
        115                 120                 125             

Gln Ala Val Glu Glu His Lys Arg Leu Asn Gly Phe Leu His Ala Ser 
    130                 135                 140                 

Val Pro Ser Ala 
145             

<210>   750
<211>   447
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   750
atgttgaccg tgccgctcga aatcgtcacg ccggagcgga tcgtgctgtc gatggacgtg       60

cgcatggtga tcctgcgggg cggcgatggc gaaatcggca tcttgccacg ccacatgccg      120

ctcgctacgg cggtgaagcc gtgcctggtg cgcattcggc tggcggacga tcgccaggac      180

gtggtaccgg tgtcaggcgg gttcgtcgag gtcctgcctg agaagatcac catcctcgcg      240

gacaccgcgg agttgcctga ggaaatcgac gtcgatcgcg cccttcgcgc caaggaccgc      300

gcggagaagc ggctgcaggc cgcggtcgac gaggaagaag cggatcgcgc gcgtcaggcg      360

ctcacgcgcg ctgaactgcg gctgcaggcg gtggaagagc acaaacgcct gaacggattt      420

ctgcacgcaa gtgtcccgag cgcttaa                                          447


<210>   751
<211>   133
<212>   PRT
<213>   Thermosinus carboxydivorans Nor1

<400>   751
Thr Val Arg Leu Asp Ile Val Thr Pro Glu Arg Leu Ala Tyr Ser Asp 
                5                   10                  15      

Asp Val Asn Met Val Ile Ala Arg Ala Thr Asp Gly Asp Ile Gly Ile 
            20                  25                  30          

Leu Pro Gly His Ala Pro Leu Ile Ala Gly Leu Glu Ile Ala Pro Leu 
        35                  40                  45              

Arg Ile Leu Lys Asp Asp Gly Glu Lys Arg Ile Ala Val Cys Gly Gly 
    50                  55                  60                  

Phe Ile Glu Val Arg Pro Asp Lys Val Thr Val Leu Ala Gly Cys Ala 
65                  70                  75                  80  

Glu Leu Pro Glu Glu Ile Asp Val Lys Arg Ala Glu Ala Ala Arg Glu 
                85                  90                  95      

Arg Ala Glu Ala Arg Leu Lys Tyr Arg Glu Gly Ile Asp Val Ala Arg 
            100                 105                 110         

Ala Glu Gln Ala Leu Lys Arg Ala Leu Met Arg Leu Ser Val Ala Glu 
        115                 120                 125             

Tyr His Lys Lys Met 
    130             

<210>   752
<211>   129
<212>   PRT
<213>   Bacillus sp. TA2.A1

<400>   752
Met Ala Thr Val Gln Val Asp Ile Val Thr Pro Glu Arg Lys Val Phe 
                5                   10                  15      

Gln Gly Glu Ala Asp Ile Val Ile Ala Arg Gly Val Glu Gly Glu Leu 
            20                  25                  30          

Gly Val Met Ala Gly His Ile Pro Leu Val Thr Pro Leu Lys Thr Ala 
        35                  40                  45              

Pro Val Arg Ile Lys Gln Gly Asp Lys Glu Thr Leu Ile Ala Val Ser 
    50                  55                  60                  

Gly Gly Phe Leu Glu Val Arg Pro Asp Lys Val Asn Ile Leu Ala Asp 
65                  70                  75                  80  

Thr Ala Glu Leu Pro Glu Glu Ile Asp Val Glu Arg Ala Lys Lys Ala 
                85                  90                  95      

Lys Ala Arg His Glu Thr Ile Leu Lys Arg Leu Asp Lys Thr Asp Lys 
            100                 105                 110         

Asp Tyr Leu Arg His Lys Arg Ala Leu Glu Arg Ala Glu Val Arg Leu 
        115                 120                 125             

Gln 
    

<210>   753
<211>   104
<212>   PRT
<213>   Bacillus pseudofirmus

<400>   753
Met Ser Thr Ile Arg Val Asn Val Val Thr Pro Asp Gly Lys Val Tyr 
                5                   10                  15      

Asp Gly Asp Val Asp Met Val Val Val Arg Thr Val Glu Gly Glu Leu 
            20                  25                  30          

Gly Ile Leu Pro Lys His Ile Pro Leu Val Ala Pro Leu Thr Val Gly 
        35                  40                  45              

Ala Val Arg Leu Lys Lys Gly Asn Ser Glu Glu Gln Val Ala Val Ser 
    50                  55                  60                  

Gly Gly Phe Val Glu Val Arg Pro Asp Gln Val Thr Ile Leu Ala Glu 
65                  70                  75                  80  

Ala Ala Glu Leu Pro Ser Ala Ile Asp Val Asp Arg Ala Arg Ala Ala 
                85                  90                  95      

Lys Glu Arg Ala Glu Ser Arg Leu 
            100                 

<210>   754
<211>   127
<212>   PRT
<213>   Halothermothrix orenii H 168

<400>   754
Thr Ile Arg Leu Glu Val Val Thr Pro Glu Lys Val Val Phe Ser Glu 
                5                   10                  15      

Pro Val Asn Ile Leu Ile Ala Pro Ala Ile Asp Gly Glu Ile Gly Ile 
            20                  25                  30          

Leu Pro Lys His Thr Pro Leu Val Thr Gly Leu Lys Thr Gly Val Met 
        35                  40                  45              

Arg Val Lys Lys Asp Gly Glu Glu Val Lys Ile Ser Ile Ser Glu Gly 
    50                  55                  60                  

Phe Met Glu Val Lys Pro Asp Glu Ile Asn Val Ile Val Arg Thr Ala 
65                  70                  75                  80  

Glu Leu Pro His Glu Ile Asp Val Glu Arg Ala Arg Asp Ala Leu Lys 
                85                  90                  95      

Arg Ala Glu Lys Arg Leu Asn Ser Arg Asn Asp Arg Ile Asp Arg Ala 
            100                 105                 110         

Arg Ala Arg Ala Ala Phe Glu Arg Ala Ile Ala Arg Leu Lys Ala 
        115                 120                 125         

<210>   755
<211>   102
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   755
Thr Phe Thr Leu Arg Val Val Ser Pro Glu Gly Asn Val Leu Lys Glu 
                5                   10                  15      

Glu Ala Glu Phe Val Val Leu Pro Gly Gly Asn Gly Glu Ile Gly Ile 
            20                  25                  30          

Leu Pro Asn His Ala Pro Leu Ile Ser Ser Ile Glu Ile Gly Val Ile 
        35                  40                  45              

Arg Tyr Thr Val Asn Gly Lys Val Glu Lys Ile Ala Thr Ser Gly Gly 
    50                  55                  60                  

Phe Val Glu Val Ser Asp Asn Lys Val Thr Ile Leu Ala Asp Thr Ala 
65                  70                  75                  80  

Glu Pro Gly Glu Lys Val Asp Leu Asp Arg Ala Leu Ala Ala Lys Glu 
                85                  90                  95      

Arg Ala Glu Lys Arg Leu 
            100         

<210>   756
<211>   148
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   756
Met Leu Thr Val Pro Leu Glu Ile Val Thr Pro Glu Arg Ile Val Leu 
                5                   10                  15      

Ser Met Asp Val Arg Met Val Ile Leu Arg Gly Gly Asp Gly Glu Ile 
            20                  25                  30          

Gly Ile Leu Pro Arg His Met Pro Leu Ala Thr Ala Val Lys Pro Cys 
        35                  40                  45              

Leu Val Arg Leu Arg Leu Ala Asp Asp Arg Gln Asp Val Val Pro Val 
    50                  55                  60                  

Ser Gly Gly Phe Val Glu Val Leu Pro Glu Lys Ile Thr Ile Leu Ala 
65                  70                  75                  80  

Asp Thr Ala Glu Leu Pro Glu Glu Ile Asp Val Asp Arg Ala Leu Arg 
                85                  90                  95      

Ala Lys Asp Arg Ala Glu Lys Arg Leu Gln Ala Ala Val Asp Glu Glu 
            100                 105                 110         

Glu Ala Asp Arg Ala Arg Gln Ala Leu Thr Arg Ala Glu Leu Arg Leu 
        115                 120                 125             

Gln Ala Val Glu Glu His Lys Arg Leu Asn Gly Phe Leu His Ala Ser 
    130                 135                 140                 

Val Pro Ser Ala 
145             

<210>   757
<211>   148
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   757
Met Leu Thr Val Pro Leu Glu Ile Val Thr Pro Glu Arg Ile Val Leu 
                5                   10                  15      

Ser Met Asp Val Arg Met Val Ile Leu Arg Gly Gly Asp Gly Glu Ile 
            20                  25                  30          

Gly Ile Leu Pro Arg His Met Pro Leu Ala Thr Ala Val Lys Pro Cys 
        35                  40                  45              

Leu Val Arg Ile Arg Leu Ala Asp Asp Arg Gln Asp Val Val Pro Val 
    50                  55                  60                  

Ser Gly Gly Phe Val Glu Val Leu Pro Glu Lys Ile Thr Ile Leu Ala 
65                  70                  75                  80  

Asp Thr Ala Glu Leu Pro Glu Glu Ile Asp Val Asp Arg Ala Leu Arg 
                85                  90                  95      

Ala Lys Asp Arg Ala Glu Arg Arg Leu Gln Ala Ala Val Asp Glu Glu 
            100                 105                 110         

Glu Ala Asp Arg Ala Arg Gln Ala Leu Thr Arg Ala Glu Leu Arg Leu 
        115                 120                 125             

Gln Ala Val Glu Glu His Lys Arg Leu Asn Gly Phe Leu His Ala Ser 
    130                 135                 140                 

Val Pro Ser Ala 
145             

<210>   758
<211>   148
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   758
Met Leu Thr Val Pro Leu Glu Ile Val Thr Pro Glu Arg Ile Val Leu 
                5                   10                  15      

Ser Met Asp Val Arg Met Val Ile Leu Arg Gly Gly Asp Gly Glu Ile 
            20                  25                  30          

Gly Ile Leu Pro Arg His Met Pro Leu Ala Thr Ala Val Lys Pro Cys 
        35                  40                  45              

Leu Val Arg Ile Arg Leu Ala Asp Asp Arg Gln Asp Val Val Pro Val 
    50                  55                  60                  

Ser Gly Gly Phe Val Glu Val Leu Pro Glu Lys Ile Thr Ile Leu Ala 
65                  70                  75                  80  

Asp Thr Ala Glu Leu Pro Glu Glu Ile Asp Val Asp Arg Ala Leu Arg 
                85                  90                  95      

Ala Lys Asp Arg Ala Glu Lys Arg Leu Gln Ala Ala Val Asp Glu Glu 
            100                 105                 110         

Glu Ala Asp Arg Ala Arg Gln Ala Leu Thr Arg Ala Glu Leu Arg Leu 
        115                 120                 125             

Gln Ala Val Glu Glu His Lys Arg Ile Asn Gly Phe Leu His Ala Ser 
    130                 135                 140                 

Val Pro Ser Ala 
145             

<210>   759
<211>   148
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   759
Met Leu Thr Val Pro Leu Glu Ile Val Thr Pro Glu Arg Ile Val Leu 
                5                   10                  15      

Ser Met Asp Val Arg Met Val Ile Leu Arg Gly Gly Asp Gly Glu Ile 
            20                  25                  30          

Gly Ile Leu Pro Arg His Met Pro Leu Ala Thr Ala Val Lys Pro Cys 
        35                  40                  45              

Leu Val Arg Ile Arg Leu Ala Asp Asp Arg Gln Asp Val Val Pro Val 
    50                  55                  60                  

Ser Gly Gly Phe Val Glu Val Leu Pro Glu Lys Ile Thr Ile Leu Ala 
65                  70                  75                  80  

Asp Thr Ala Glu Leu Pro Glu Glu Ile Asp Val Asp Arg Ala Leu Arg 
                85                  90                  95      

Ala Lys Asp Arg Ala Glu Lys Arg Ile Gln Ala Ala Val Asp Glu Glu 
            100                 105                 110         

Glu Ala Asp Arg Ala Arg Gln Ala Leu Thr Arg Ala Glu Leu Arg Leu 
        115                 120                 125             

Gln Ala Val Glu Glu His Lys Arg Leu Asn Gly Phe Leu His Ala Ser 
    130                 135                 140                 

Val Pro Ser Ala 
145             

<210>   760
<211>   148
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   760
Met Leu Thr Val Pro Leu Glu Ile Val Thr Pro Glu Arg Ile Val Leu 
                5                   10                  15      

Ser Met Asp Val Arg Met Val Ile Leu Arg Gly Gly Asp Gly Glu Ile 
            20                  25                  30          

Gly Ile Leu Pro Arg His Met Pro Leu Ala Thr Ala Val Lys Pro Cys 
        35                  40                  45              

Leu Val Arg Ile Arg Leu Ala Asp Glu Arg Gln Asp Val Val Pro Val 
    50                  55                  60                  

Ser Gly Gly Phe Val Glu Val Leu Pro Glu Lys Ile Thr Ile Leu Ala 
65                  70                  75                  80  

Asp Thr Ala Glu Leu Pro Glu Glu Ile Asp Val Asp Arg Ala Leu Arg 
                85                  90                  95      

Ala Lys Asp Arg Ala Glu Lys Arg Leu Gln Ala Ala Val Asp Glu Glu 
            100                 105                 110         

Glu Ala Asp Arg Ala Arg Gln Ala Leu Thr Arg Ala Glu Leu Arg Leu 
        115                 120                 125             

Gln Ala Val Glu Glu His Lys Arg Leu Asn Gly Phe Leu His Ala Ser 
    130                 135                 140                 

Val Pro Ser Ala 
145             

<210>   761
<211>   447
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   761
atgttgaccg tgccgctcga aatcgtcacg ccggagcgga tcgtgctgtc gatggacgtg       60

cgcatggtga tcctgcgggg cggcgatggc gaaatcggca tcttgccacg ccacatgccg      120

ctcgctacgg cggtgaagcc gtgcctggtg cgcttacggc tggcggacga tcgccaggac      180

gtggtaccgg tgtcaggcgg gttcgtcgag gtcctgcctg agaagatcac catcctcgcg      240

gacaccgcgg agttgcctga ggaaatcgac gtcgatcgcg cccttcgcgc caaggaccgc      300

gcggagaagc ggctgcaggc cgcggtcgac gaggaagaag cggatcgcgc gcgtcaggcg      360

ctcacgcgcg ctgaactgcg gctgcaggcg gtggaagagc acaaacgcct gaacggattt      420

ctgcacgcaa gtgtcccgag cgcttaa                                          447


<210>   762
<211>   447
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   762
atgttgaccg tgccgctcga aatcgtcacg ccggagcgga tcgtgctgtc gatggacgtg       60

cgcatggtga tcctgcgggg cggcgatggc gaaatcggca tcttgccacg ccacatgccg      120

ctcgctacgg cggtgaagcc gtgcctggtg cgcattcggc tggcggacga tcgccaggac      180

gtggtaccgg tgtcaggcgg gttcgtcgag gtcctgcctg agaagatcac catcctcgcg      240

gacaccgcgg agttgcctga ggaaatcgac gtcgatcgcg cccttcgcgc caaggaccgc      300

gcggagcgtc ggctgcaggc cgcggtcgac gaggaagaag cggatcgcgc gcgtcaggcg      360

ctcacgcgcg ctgaactgcg gctgcaggcg gtggaagagc acaaacgcct gaacggattt      420

ctgcacgcaa gtgtcccgag cgcttaa                                          447


<210>   763
<211>   447
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   763
atgttgaccg tgccgctcga aatcgtcacg ccggagcgga tcgtgctgtc gatggacgtg       60

cgcatggtga tcctgcgggg cggcgatggc gaaatcggca tcttgccacg ccacatgccg      120

ctcgctacgg cggtgaagcc gtgcctggtg cgcattcggc tggcggacga tcgccaggac      180

gtggtaccgg tgtcaggcgg gttcgtcgag gtcctgcctg agaagatcac catcctcgcg      240

gacaccgcgg agttgcctga ggaaatcgac gtcgatcgcg cccttcgcgc caaggaccgc      300

gcggagaagc ggctgcaggc cgcggtcgac gaggaagaag cggatcgcgc gcgtcaggcg      360

ctcacgcgcg ctgaactgcg gctgcaggcg gtggaagagc acaaacgcat taacggattt      420

ctgcacgcaa gtgtcccgag cgcttaa                                          447


<210>   764
<211>   447
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   764
atgttgaccg tgccgctcga aatcgtcacg ccggagcgga tcgtgctgtc gatggacgtg       60

cgcatggtga tcctgcgggg cggcgatggc gaaatcggca tcttgccacg ccacatgccg      120

ctcgctacgg cggtgaagcc gtgcctggtg cgcattcggc tggcggacga tcgccaggac      180

gtggtaccgg tgtcaggcgg gttcgtcgag gtcctgcctg agaagatcac catcctcgcg      240

gacaccgcgg agttgcctga ggaaatcgac gtcgatcgcg cccttcgcgc caaggaccgc      300

gcggagaagc ggattcaggc cgcggtcgac gaggaagaag cggatcgcgc gcgtcaggcg      360

ctcacgcgcg ctgaactgcg gctgcaggcg gtggaagagc acaaacgcct gaacggattt      420

ctgcacgcaa gtgtcccgag cgcttaa                                          447


<210>   765
<211>   447
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   765
atgttgaccg tgccgctcga aatcgtcacg ccggagcgga tcgtgctgtc gatggacgtg       60

cgcatggtga tcctgcgggg cggcgatggc gaaatcggca tcttgccacg ccacatgccg      120

ctcgctacgg cggtgaagcc gtgcctggtg cgcattcggc tggcggacga acgccaggac      180

gtggtaccgg tgtcaggcgg gttcgtcgag gtcctgcctg agaagatcac catcctcgcg      240

gacaccgcgg agttgcctga ggaaatcgac gtcgatcgcg cccttcgcgc caaggaccgc      300

gcggagaagc ggctgcaggc cgcggtcgac gaggaagaag cggatcgcgc gcgtcaggcg      360

ctcacgcgcg ctgaactgcg gctgcaggcg gtggaagagc acaaacgcct gaacggattt      420

ctgcacgcaa gtgtcccgag cgcttaa                                          447


<210>   766
<211>   497
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   766
Met Phe Trp Leu Leu Pro Arg Tyr Ala Pro Gly Leu Thr Gln Phe Ala 
                5                   10                  15      

Val Ala His Val Asp Gly Ala Arg Ile Tyr Leu Cys Leu Asn Leu Tyr 
            20                  25                  30          

Ser Gly Pro Val His Arg Ser Cys Arg Arg Ala Ser Cys Lys Arg Glu 
        35                  40                  45              

Thr Ile Gly Val Asp Gly Val Lys Ser Glu His Leu Leu Asp Val Arg 
    50                  55                  60                  

Pro Arg Val Asp Ala His Phe Pro Arg Asp Glu Lys Gly His Leu Leu 
65                  70                  75                  80  

Ile Gly Gly Val Ser Ala Val Asp Leu Val Ala Gln Phe Gly Thr Pro 
                85                  90                  95      

Leu Ile Ala Tyr Asp Glu Gly Leu Ile Arg Asp Thr Ile Arg Ala Phe 
            100                 105                 110         

His Arg Val Phe Gln Asp Glu Gly Val Pro Tyr Gln Ile Ser Tyr Ala 
        115                 120                 125             

Ser Lys Ala Phe Cys Thr Met Ala Ile Cys Gln Leu Ala His Glu Glu 
    130                 135                 140                 

Gly Leu Gly Ile Asp Val Val Ser Gly Gly Glu Leu Tyr Thr Ala Leu 
145                 150                 155                 160 

Ala Ala Gly Val Pro Ala Ser Lys Leu His Met His Gly Asn Asn Lys 
                165                 170                 175     

Thr Pro Glu Glu Leu Glu Tyr Ala Ile Glu Ser Gly Ile Gly Ala Val 
            180                 185                 190         

Ile Val Asp Asn Phe Asp Glu Ile Asp Leu Leu Ala Asp Ile Leu Gln 
        195                 200                 205             

Glu Thr Gly Arg Thr Val Asp Val Leu Val Arg Val Ala Pro Gly Val 
    210                 215                 220                 

Glu Ala His Thr His Asp Tyr Ile Ser Thr Gly Gln Gln Asp Ser Lys 
225                 230                 235                 240 

Phe Gly Phe Asp Leu Ala Ser His Gln Val Glu Glu Ala Phe Ser Arg 
                245                 250                 255     

Leu Lys Glu Val Glu Arg Ala Arg Val Ile Gly Val His Ala His Ile 
            260                 265                 270         

Gly Ser Gln Ile Phe Asp Val Glu Gly Phe Arg Leu Leu Ala Asp Arg 
        275                 280                 285             

Met Ala Gly Val Tyr Glu Asp Gly Leu Arg Arg Phe Gly Leu Pro Phe 
    290                 295                 300                 

Ser Val Leu Asn Leu Gly Gly Gly Phe Gly Ile Pro Tyr Thr Asp Glu 
305                 310                 315                 320 

Asp Ala Pro Pro Val Ala Asp Leu Val Arg Gly Val Ile Arg Ala Ala 
                325                 330                 335     

Lys Ala Ala Phe Ala Ala Arg Gly Met Asp Val Pro Val Leu Trp Ile 
            340                 345                 350         

Glu Pro Gly Arg Ser Ile Val Gly Pro Ala Gly Val Thr Leu Tyr Arg 
        355                 360                 365             

Val Gly Ser Arg Lys Val Ile Pro Gly Val Arg Asn Tyr Val Ala Ile 
    370                 375                 380                 

Asp Gly Gly Met Thr Asp Asn Pro Arg Leu Ala Leu Tyr Gly Ala Lys 
385                 390                 395                 400 

Tyr His Ala Cys Tyr Ala Asn Arg Ala Ala Asp Pro Pro Asp Arg Pro 
                405                 410                 415     

Trp Ser Val Ala Gly Lys Cys Cys Glu Ser Gly Asp Met Leu Ile Trp 
            420                 425                 430         

Asp Leu Pro Leu Pro Asp Pro Gln Pro Gly Asp Leu Leu Ala Val Phe 
        435                 440                 445             

Ala Thr Gly Ala Tyr Thr Tyr Ala Met Ala Ser His Tyr Asn Arg Ile 
    450                 455                 460                 

Pro Lys Pro Ala Val Val Phe Cys Arg Asp Gly Glu Ala Arg Leu Val 
465                 470                 475                 480 

Ala Arg Arg Glu Thr Trp Ala Asp Val Ala Arg Leu Asp Val Pro Leu 
                485                 490                 495     

Arg 
    

<210>   767
<211>   1494
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   767
gtgttctggc ttttaccgcg ctatgcaccg ggcttaacgc aatttgccgt tgcccacgtc       60

gatggcgcac gtatatactt gtgtctgaat ctttattcag gtcctgtaca caggtcgtgt      120

cgccgcgcgt catgcaagag agagacgata ggagtggacg gagtgaaatc agagcacctg      180

ttggacgtga ggccgagggt ggacgcgcat tttccgcgag acgaaaaggg tcatcttctc      240

atcggcgggg tgagcgcggt cgatctcgtg gcacagttcg gcacgccgct catcgcgtac      300

gacgaggggc tgattcgcga taccatccgc gcgtttcacc gcgtgtttca agacgaaggc      360

gtgccctatc agatttctta cgccagcaag gccttctgca ccatggccat ctgccaactc      420

gcgcacgagg agggcttggg catcgacgtg gtgtccggcg gcgagttgta caccgcgctc      480

gcggccggcg tgccggcgag caagctccac atgcatggca acaacaaaac gccggaggaa      540

ctcgaatacg ccattgagag cggcatcggg gccgtgatcg tggacaattt cgacgagatc      600

gatctcctgg ccgatatcct tcaagaaacc gggcgcacgg tcgatgtcct ggtgcgggtg      660

gcgccaggtg tcgaggcgca cacgcacgac tacatctcca ccgggcagca ggactccaag      720

tttggcttcg atctcgccag ccaccaggtg gaggaggcct tttcgcggct caaagaggtg      780

gaacgcgcgc gggtcatcgg cgtgcatgcg cacatcggat cgcagatctt cgatgtggag      840

ggctttcgac tgctcgccga tcgaatggcg ggcgtgtacg aagacggcct gcgccggttc      900

ggcctgccct tttccgtgct caacctgggt ggcgggtttg gcatcccgta cacggatgag      960

gatgcgccgc cggtggccga tctcgtccgg ggtgtgatcc gcgccgccaa ggcggccttt     1020

gcggcgcgag gcatggacgt gccggtgctc tggattgaac ccggccgaag catcgtcggg     1080

cccgcgggcg tgacgctgta ccgcgtgggc agtcgcaagg tcattccggg cgtgcggaat     1140

tacgtcgcca tcgacggggg catgacggac aacccgcgcc tggcgctcta tggcgcgaag     1200

taccacgcgt gttacgcaaa tcgggcggcg gatccgccgg atcgcccgtg gtcggtggcg     1260

ggcaagtgct gcgagagcgg ggacatgctc atctgggatc tcccgcttcc ggatccgcag     1320

ccgggggatc tcctcgccgt cttcgcgacc ggcgcgtaca cgtatgcgat ggcgagccac     1380

tacaaccgca ttcccaagcc cgccgtcgtg ttttgccgcg atggcgaggc gcgcctcgtg     1440

gcgcggcgcg agacgtgggc ggacgtggcg cggctcgatg tgccgcttcg gtga           1494


<210>   768
<211>   426
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   768
Gln Asn Glu Arg Gly His Leu Glu Ile Gly Gly Val Asp Val Leu Ser 
                5                   10                  15      

Leu Ala Glu Arg Tyr Gly Thr Pro Leu Tyr Val Tyr Asp Val Ala Leu 
            20                  25                  30          

Ile Arg Glu Arg Ala Arg Lys Phe Gln Lys Ala Phe Lys Glu Ala Gly 
        35                  40                  45              

Leu Lys Ala Gln Val Ala Tyr Ala Ser Lys Ala Phe Ser Ser Val Ala 
    50                  55                  60                  

Met Ile Gln Leu Ala Glu Gln Glu Gly Leu Ser Leu Asp Val Val Ser 
65                  70                  75                  80  

Gly Gly Glu Leu Phe Thr Ala Ile Lys Ala Gly Phe Pro Ala Glu Arg 
                85                  90                  95      

Ile His Phe His Gly Asn Asn Lys Ser Pro Glu Glu Leu Ala Met Ala 
            100                 105                 110         

Leu Glu His Gln Ile Gly Cys Ile Val Leu Asp Asn Phe His Glu Ile 
        115                 120                 125             

Ala Ile Thr Glu Asp Leu Cys Lys Arg Ser Gly Gln Thr Val Asp Val 
    130                 135                 140                 

Leu Leu Arg Ile Thr Pro Gly Val Glu Ala His Thr His Asp Tyr Ile 
145                 150                 155                 160 

Thr Thr Gly Gln Glu Asp Ser Lys Phe Gly Phe Asp Leu His Asn Gly 
                165                 170                 175     

Gln Val Glu Gln Ala Ile Glu Gln Val Leu Arg Ser Ser Ala Phe Lys 
            180                 185                 190         

Leu Leu Gly Val His Cys His Ile Gly Ser Gln Ile Phe Asp Thr Ala 
        195                 200                 205             

Gly Phe Val Leu Ala Ala Asp Lys Ile Phe Glu Lys Leu Ala Glu Trp 
    210                 215                 220                 

Arg Glu Thr Tyr Ser Phe Ile Pro Glu Val Leu Asn Leu Gly Gly Gly 
225                 230                 235                 240 

Phe Gly Ile Arg Tyr Thr Lys Asp Asp Glu Pro Leu Ala Ala Asp Val 
                245                 250                 255     

Tyr Val Glu Lys Ile Ile Glu Ala Val Lys Ala Asn Ala Glu His Phe 
            260                 265                 270         

Gly Phe Asp Ile Pro Glu Ile Trp Ile Glu Pro Gly Arg Ser Leu Val 
        275                 280                 285             

Gly Asp Ala Gly Thr Thr Leu Tyr Thr Ile Gly Ser Gln Lys Glu Val 
    290                 295                 300                 

Pro Gly Ile Arg Lys Tyr Val Ala Ile Asp Gly Gly Met Ser Asp Asn 
305                 310                 315                 320 

Ile Arg Pro Ala Leu Tyr Glu Ala Lys Tyr Glu Ala Ala Val Ala Asn 
                325                 330                 335     

Arg Met Asn Asp Ala Cys His Asp Thr Ala Ser Ile Ala Gly Lys Cys 
            340                 345                 350         

Cys Glu Ser Gly Asp Met Leu Ile Trp Asp Leu Glu Ile Pro Glu Val 
        355                 360                 365             

Arg Asp Gly Asp Val Leu Ala Val Phe Cys Thr Gly Ala Tyr Gly Tyr 
    370                 375                 380                 

Ser Met Ala Asn Asn Tyr Asn Arg Ile Pro Arg Pro Ala Val Val Phe 
385                 390                 395                 400 

Val Glu Asp Gly Glu Ala Gln Leu Val Ile Gln Arg Glu Thr Tyr Glu 
                405                 410                 415     

Asp Ile Val Lys Leu Asp Leu Pro Leu Lys 
            420                 425     

<210>   769
<211>   426
<212>   PRT
<213>   Bacillus subtilis

<400>   769
Gln Asn Gln His Gly His Leu Glu Ile Gly Gly Val Asp Ala Leu Tyr 
                5                   10                  15      

Leu Ala Glu Lys Tyr Gly Thr Pro Leu Tyr Val Tyr Asp Val Ala Leu 
            20                  25                  30          

Ile Arg Glu Arg Ala Lys Ser Phe Lys Gln Ala Phe Ile Ser Ala Gly 
        35                  40                  45              

Leu Lys Ala Gln Val Ala Tyr Ala Ser Lys Ala Phe Ser Ser Val Ala 
    50                  55                  60                  

Met Ile Gln Leu Ala Glu Glu Glu Gly Leu Ser Leu Asp Val Val Ser 
65                  70                  75                  80  

Gly Gly Glu Leu Tyr Thr Ala Val Ala Ala Gly Phe Pro Ala Glu Arg 
                85                  90                  95      

Ile His Phe His Gly Asn Asn Lys Ser Arg Glu Glu Leu Arg Met Ala 
            100                 105                 110         

Leu Glu His Arg Ile Gly Cys Ile Val Val Asp Asn Phe Tyr Glu Ile 
        115                 120                 125             

Ala Leu Leu Glu Asp Leu Cys Lys Glu Thr Gly His Ser Ile Asp Val 
    130                 135                 140                 

Leu Leu Arg Ile Thr Pro Gly Val Glu Ala His Thr His Asp Tyr Ile 
145                 150                 155                 160 

Thr Thr Gly Gln Glu Asp Ser Lys Phe Gly Phe Asp Leu His Asn Gly 
                165                 170                 175     

Gln Thr Glu Arg Ala Ile Glu Gln Val Leu Gln Ser Glu His Ile Gln 
            180                 185                 190         

Leu Leu Gly Val His Cys His Ile Gly Ser Gln Ile Phe Asp Thr Ala 
        195                 200                 205             

Gly Phe Val Leu Ala Ala Glu Lys Ile Phe Lys Lys Leu Asp Glu Trp 
    210                 215                 220                 

Arg Asp Ser Tyr Ser Phe Val Ser Lys Val Leu Asn Leu Gly Gly Gly 
225                 230                 235                 240 

Phe Gly Ile Arg Tyr Thr Glu Asp Asp Glu Pro Leu His Ala Thr Glu 
                245                 250                 255     

Tyr Val Glu Lys Ile Ile Glu Ala Val Lys Glu Asn Ala Ser Arg Tyr 
            260                 265                 270         

Gly Phe Asp Ile Pro Glu Ile Trp Ile Glu Pro Gly Arg Ser Leu Val 
        275                 280                 285             

Gly Asp Ala Gly Thr Thr Leu Tyr Thr Val Gly Ser Gln Lys Glu Val 
    290                 295                 300                 

Pro Gly Val Arg Gln Tyr Val Ala Val Asp Gly Gly Met Asn Asp Asn 
305                 310                 315                 320 

Ile Arg Pro Ala Leu Tyr Gln Ala Lys Tyr Glu Ala Ala Ala Ala Asn 
                325                 330                 335     

Arg Ile Gly Glu Ala His Asp Lys Thr Val Ser Ile Ala Gly Lys Cys 
            340                 345                 350         

Cys Glu Ser Gly Asp Met Leu Ile Trp Asp Ile Asp Leu Pro Glu Val 
        355                 360                 365             

Lys Glu Gly Asp Leu Leu Ala Val Phe Cys Thr Gly Ala Tyr Gly Tyr 
    370                 375                 380                 

Ser Met Ala Asn Asn Tyr Asn Arg Ile Pro Arg Pro Ala Val Val Phe 
385                 390                 395                 400 

Val Glu Asn Gly Glu Ala His Leu Val Val Lys Arg Glu Thr Tyr Glu 
                405                 410                 415     

Asp Ile Val Lys Leu Asp Leu Pro Phe Lys 
            420                 425     

<210>   770
<211>   426
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   770
Gln Asn Gln His Gly His Leu Glu Ile Gly Gly Val Asp Ala Leu Tyr 
                5                   10                  15      

Leu Ala Glu Lys Tyr Gly Thr Pro Leu Tyr Val Tyr Asp Val Ala Leu 
            20                  25                  30          

Ile Arg Glu Arg Ala Lys Ser Phe Lys Gln Ala Phe Ile Ser Ala Gly 
        35                  40                  45              

Leu Lys Ala Gln Val Ala Tyr Ala Ser Lys Ala Phe Ser Ser Val Ala 
    50                  55                  60                  

Met Ile Gln Leu Ala Glu Glu Glu Gly Leu Ser Leu Asp Val Val Ser 
65                  70                  75                  80  

Gly Gly Glu Leu Tyr Thr Ala Val Ala Ala Gly Phe Pro Ala Glu Arg 
                85                  90                  95      

Ile His Phe His Gly Asn Asn Lys Ser Arg Glu Glu Leu Arg Met Ala 
            100                 105                 110         

Leu Glu His Arg Ile Gly Cys Ile Val Val Asp Asn Phe Tyr Glu Ile 
        115                 120                 125             

Ala Leu Leu Glu Asp Leu Cys Lys Glu Thr Gly His Ser Ile Asp Val 
    130                 135                 140                 

Leu Leu Arg Ile Thr Pro Gly Val Glu Ala His Thr His Asp Tyr Ile 
145                 150                 155                 160 

Thr Thr Gly Gln Glu Asp Ser Lys Phe Gly Phe Asp Leu His Asn Gly 
                165                 170                 175     

Gln Thr Glu Arg Ala Ile Glu Gln Val Leu Gln Ser Glu His Ile Gln 
            180                 185                 190         

Leu Leu Gly Val His Cys His Ile Gly Ser Gln Ile Phe Asp Thr Ala 
        195                 200                 205             

Gly Phe Val Leu Ala Ala Glu Lys Ile Phe Lys Lys Leu Asp Glu Trp 
    210                 215                 220                 

Arg Asp Ser Tyr Ser Phe Val Ser Lys Val Leu Asn Leu Gly Gly Gly 
225                 230                 235                 240 

Phe Gly Ile Arg Tyr Thr Glu Asp Asp Glu Pro Leu His Ala Thr Glu 
                245                 250                 255     

Tyr Val Glu Lys Ile Ile Glu Ala Val Lys Glu Asn Ala Ser Arg Tyr 
            260                 265                 270         

Gly Phe Asp Ile Pro Glu Ile Trp Ile Glu Pro Gly Arg Ser Leu Val 
        275                 280                 285             

Gly Asp Ala Gly Thr Thr Leu Tyr Thr Val Gly Ser Gln Lys Glu Val 
    290                 295                 300                 

Pro Gly Val Arg Gln Tyr Val Ala Val Asp Gly Gly Met Asn Asp Asn 
305                 310                 315                 320 

Ile Arg Pro Ala Leu Tyr Gln Ala Lys Tyr Glu Ala Ala Ala Ala Asn 
                325                 330                 335     

Arg Ile Gly Glu Ala His Asp Lys Thr Val Ser Ile Ala Gly Lys Cys 
            340                 345                 350         

Cys Glu Ser Gly Asp Met Leu Ile Trp Asp Ile Asp Leu Pro Glu Val 
        355                 360                 365             

Lys Glu Gly Asp Leu Leu Ala Val Phe Cys Thr Gly Ala Tyr Gly Tyr 
    370                 375                 380                 

Ser Met Ala Asn Asn Tyr Asn Arg Ile Pro Arg Pro Ala Val Val Phe 
385                 390                 395                 400 

Val Glu Asn Gly Glu Ala His Leu Val Val Lys Arg Glu Thr Tyr Glu 
                405                 410                 415     

Asp Ile Val Lys Leu Asp Leu Pro Phe Lys 
            420                 425     

<210>   771
<211>   426
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   771
Gln Asn Lys Leu Gly His Leu Glu Ile Gly Gly Val Asp Ala Leu Tyr 
                5                   10                  15      

Leu Ala Glu His Tyr Gly Thr Pro Leu Tyr Val Tyr Asp Val Ala Leu 
            20                  25                  30          

Ile Arg Glu Arg Ala Lys Ser Phe Lys Gln Ala Phe Ile Asp Ala Asp 
        35                  40                  45              

Leu Lys Ala Gln Val Ala Tyr Ala Ser Lys Ala Phe Ser Ser Val Ala 
    50                  55                  60                  

Met Ile Gln Leu Ala Glu Gln Glu Gly Leu Ser Leu Asp Val Val Ser 
65                  70                  75                  80  

Gly Gly Glu Leu Phe Thr Ala Val Ala Ala Gly Phe Pro Ala Asp Arg 
                85                  90                  95      

Ile His Phe His Gly Asn Asn Lys Ser Glu Glu Glu Leu Lys Met Ala 
            100                 105                 110         

Leu Asp His Gln Ile Gly Cys Ile Val Val Asp Asn Phe Tyr Glu Ile 
        115                 120                 125             

Ser Leu Leu Ala Glu Leu Cys Arg Lys Ser Gly Arg Thr Met Asp Val 
    130                 135                 140                 

Leu Leu Arg Ile Thr Pro Gly Val Glu Ala His Thr His Asp Tyr Ile 
145                 150                 155                 160 

Thr Thr Gly Gln Glu Asp Ser Lys Phe Gly Phe Asp Leu His Asn Gly 
                165                 170                 175     

Gln Ile Glu Lys Ala Ile Glu Gln Val Leu Gln Ser Asp His Ile Arg 
            180                 185                 190         

Leu Leu Gly Val His Cys His Ile Gly Ser Gln Ile Phe Asp Thr Ala 
        195                 200                 205             

Gly Phe Val Leu Ala Ala Glu Lys Ile Phe Ala Lys Leu Asn Glu Trp 
    210                 215                 220                 

Arg Glu Ser Phe Gly Phe Val Ser Glu Val Leu Asn Leu Gly Gly Gly 
225                 230                 235                 240 

Phe Gly Ile Arg Tyr Thr Glu Glu Asp Glu Pro Leu His Pro Ala Val 
                245                 250                 255     

Tyr Val Glu Lys Ile Ile Glu Ala Val Lys Glu Asn Ala Ala Leu His 
            260                 265                 270         

Ala Phe Asp Ile Pro Glu Ile Trp Ile Glu Pro Gly Arg Ser Leu Val 
        275                 280                 285             

Gly Asp Ala Gly Thr Thr Leu Tyr Thr Ile Gly Ser Gln Lys Glu Val 
    290                 295                 300                 

Pro Gly Thr Arg Lys Tyr Ala Ala Val Asp Gly Gly Met Ser Asp Asn 
305                 310                 315                 320 

Ile Arg Pro Ala Leu Tyr Gln Ala Lys Tyr Glu Ala Val Ser Ala Asn 
                325                 330                 335     

Arg Ile Gly Glu His His Asp Lys Thr Val Ser Ile Ala Gly Lys Cys 
            340                 345                 350         

Cys Glu Ser Gly Asp Met Leu Ile Trp Asp Ile Asp Leu Pro Glu Val 
        355                 360                 365             

Lys Glu Gly Asp Leu Leu Ala Val Phe Cys Thr Gly Ala Tyr Gly Tyr 
    370                 375                 380                 

Ser Met Ala Asn Asn Tyr Asn Arg Ile Pro Arg Pro Ala Val Val Phe 
385                 390                 395                 400 

Val Glu Asp Gly Glu Ala His Leu Val Ile Arg Arg Glu Thr Tyr Glu 
                405                 410                 415     

Asp Ile Val Lys Leu Asp Leu Pro Phe Lys 
            420                 425     

<210>   772
<211>   424
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   772
Gln Asn Glu Leu Gly His Leu Glu Ile Gly Gly Val Asp Ala Val Ser 
                5                   10                  15      

Leu Ala Glu Thr Tyr Gly Thr Pro Leu Tyr Val Tyr Asp Val Ala Leu 
            20                  25                  30          

Ile Arg Glu Arg Ala Lys Ser Phe Gln Lys Ala Phe Ile Glu Glu Glu 
        35                  40                  45              

Leu Thr Ala Gln Val Ala Tyr Ala Ser Lys Ala Phe Ser Ser Ile Ala 
    50                  55                  60                  

Met Phe Gln Leu Ala Lys Glu Glu Gly Leu Ser Leu Asp Val Val Ser 
65                  70                  75                  80  

Gly Gly Glu Leu His Thr Ala Ile Cys Ala Gly Phe Pro Val Glu Lys 
                85                  90                  95      

Ile His Phe His Gly Asn Asn Lys Ser Arg Asp Glu Leu Lys Met Ala 
            100                 105                 110         

Leu Glu Asn Glu Ile Gly Cys Ile Val Val Asp Asn Phe Tyr Glu Met 
        115                 120                 125             

Lys Leu Leu Glu Glu Leu Gly Gln Glu Leu Ser Lys Gln Val Lys Val 
    130                 135                 140                 

Leu Leu Arg Ile Thr Pro Gly Val Glu Ala His Thr His Asp Tyr Ile 
145                 150                 155                 160 

Thr Thr Gly Gln Glu Asp Ser Lys Phe Gly Phe Asp Leu His Asn Gly 
                165                 170                 175     

Gln Ala Asp Glu Ala Val Lys Arg Val Leu Glu Ser Glu Val Ile Glu 
            180                 185                 190         

Leu Leu Gly Val His Cys His Ile Gly Ser Gln Ile Phe Asp Thr Ala 
        195                 200                 205             

Gly Phe Val Leu Ala Ala Asp Lys Ile Phe Leu Lys Leu Asn Glu Trp 
    210                 215                 220                 

Arg Glu Ser Phe Gly Phe Ile Ser Thr Val Leu Asn Leu Gly Gly Gly 
225                 230                 235                 240 

Phe Gly Ile Arg Tyr Thr Glu Glu Asp Glu Pro Leu Pro Ala Thr Glu 
                245                 250                 255     

Tyr Val Glu Lys Ile Ile Gln Ala Val Lys Glu Asn Val Ala Arg Tyr 
            260                 265                 270         

Glu Phe Asp Met Pro Glu Ile Trp Ile Glu Pro Gly Arg Ser Leu Val 
        275                 280                 285             

Gly Asp Ala Gly Thr Thr Leu Tyr Thr Ile Gly Ser Ser Lys His Val 
    290                 295                 300                 

Pro Gly Ile Arg Asp Tyr Val Ala Val Asp Gly Gly Met Ser Asp Asn 
305                 310                 315                 320 

Ile Arg Pro Ala Leu Tyr Gln Ala Lys Tyr Glu Ala Ala Ser Ala Asn 
                325                 330                 335     

Lys Met Ser Gln Ser His Asp Gln Thr Val Ser Ile Ala Gly Lys Cys 
            340                 345                 350         

Cys Glu Ser Gly Asp Met Leu Ile Trp Asp Ile Asp Leu Pro Glu Leu 
        355                 360                 365             

Ser Gln Gly Asp Leu Leu Ala Val Phe Cys Thr Gly Ala Tyr Gly Tyr 
    370                 375                 380                 

Ser Met Ser Asn Asn Tyr Asn Arg Ile Pro Arg Pro Ala Val Val Phe 
385                 390                 395                 400 

Val Glu Asp Gly Glu Ala Gln Leu Val Val Glu Arg Glu Ser Tyr Ala 
                405                 410                 415     

Asp Met Val Lys Leu Asp Leu Pro 
            420                 

<210>   773
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   773
Met Phe Trp Leu Leu Pro Arg Tyr Ala Pro Gly Leu Thr Gln Phe Ala 
                5                   10                  15      

Val Ala His Val Asp Gly Ala Arg Ile Tyr Leu Cys Leu Asn Leu Tyr 
            20                  25                  30          

Ser Gly Pro Val His Arg Ser Cys Arg Arg Ala Ser Cys Lys Arg Glu 
        35                  40                  45              

Thr Ile Gly Val Asp Gly Val Lys Ser Glu His Leu Leu Asp Val Arg 
    50                  55                  60                  

Pro Arg Val Asp Ala His Phe Pro Arg Asp Glu Lys Gly His Leu Leu 
65                  70                  75                  80  

Ile Gly Gly Val Ser Ala Val Glu Leu Val Ala Gln Phe Gly Thr Pro 
                85                  90                  95      

Leu Ile Ala Tyr Asp Glu Gly Leu Ile Arg Asp Thr Ile Arg Ala Phe 
            100                 105                 110         

His Arg Val Phe Gln Asp Glu Gly Val Pro Tyr Gln Ile Ser Tyr Ala 
        115                 120                 125             

Ser Lys Ala Phe Cys Thr Met Ala Ile Cys Gln Leu Ala His Glu Glu 
    130                 135                 140                 

Gly Leu Gly Ile Asp Val Val Ser Gly Gly Glu Leu Tyr Thr Ala Leu 
145                 150                 155                 160 

Ala Ala Gly Val Pro Ala Ser Lys Leu His Met His Gly Asn Asn Lys 
                165                 170                 175     

Thr Pro Glu Glu Leu Glu Tyr Ala Ile Glu Ser Gly Ile Gly Ala Val 
            180                 185                 190         

Ile Val Asp Asn Phe Asp Glu Ile Asp Leu Leu Ala Asp Ile Leu Gln 
        195                 200                 205             

Glu Thr Gly Arg Thr Val Asp Val Leu Val Arg Val Ala Pro Gly Val 
    210                 215                 220                 

Glu Ala His Thr His Asp Tyr Ile Ser Thr Gly Gln Gln Asp Ser Lys 
225                 230                 235                 240 

Phe Gly Phe Asp Leu Ala Ser His Gln Val Glu Glu Ala Phe Ser Arg 
                245                 250                 255     

Leu Lys Glu Val Glu Arg Ala Arg Val Ile Gly Val His Ala His Ile 
            260                 265                 270         

Gly Ser Gln Ile Phe Asp Val Glu Gly Phe Arg Leu Leu Ala Asp Arg 
        275                 280                 285             

Met Ala Gly Val Tyr Glu Asp Gly Leu Arg Arg Phe Gly Leu Pro Phe 
    290                 295                 300                 

Ser Val Leu Asn Leu Gly Gly Gly Phe Gly Ile Pro Tyr Thr Asp Glu 
305                 310                 315                 320 

Asp Ala Pro Pro Val Ala Asp Leu Val Arg Gly Val Ile Arg Ala Ala 
                325                 330                 335     

Lys Ala Ala Phe Ala Ala Arg Gly Met Asp Val Pro Val Leu Trp Ile 
            340                 345                 350         

Glu Pro Gly Arg Ser Ile Val Gly Pro Ala Gly Val Thr Leu Tyr Arg 
        355                 360                 365             

Val Gly Ser Arg Lys Val Ile Pro Gly Val Arg Asn Tyr Val Ala Ile 
    370                 375                 380                 

Asp Gly Gly Met Thr Asp Asn Pro Arg Leu Ala Leu Tyr Gly Ala Lys 
385                 390                 395                 400 

Tyr His Ala Cys Tyr Ala Asn Arg Ala Ala Asp Pro Pro Asp Arg Pro 
                405                 410                 415     

Trp Ser Val Ala Gly Lys Cys Cys Glu Ser Gly Asp Met Leu Ile Trp 
            420                 425                 430         

Asp Leu Pro Leu Pro Asp Pro Gln Pro Gly Asp Leu Leu Ala Val Phe 
        435                 440                 445             

Ala Thr Gly Ala Tyr Thr Tyr Ala Met Ala Ser His Tyr Asn Arg Ile 
    450                 455                 460                 

Pro Lys Pro Ala Val Val Phe Cys Arg Asp Gly Glu Ala Arg Leu Val 
465                 470                 475                 480 

Ala Arg Arg Glu Thr Trp Ala Asp Val Ala Arg Leu Asp Val Pro Leu 
                485                 490                 495     

Arg 
    

<210>   774
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   774
Met Phe Trp Leu Leu Pro Arg Tyr Ala Pro Gly Leu Thr Gln Phe Ala 
                5                   10                  15      

Val Ala His Val Asp Gly Ala Arg Ile Tyr Leu Cys Leu Asn Leu Tyr 
            20                  25                  30          

Ser Gly Pro Val His Arg Ser Cys Arg Arg Ala Ser Cys Lys Lys Glu 
        35                  40                  45              

Thr Ile Gly Val Asp Gly Val Lys Ser Glu His Leu Leu Asp Val Arg 
    50                  55                  60                  

Pro Arg Val Asp Ala His Phe Pro Arg Asp Glu Lys Gly His Leu Leu 
65                  70                  75                  80  

Ile Gly Gly Val Ser Ala Val Asp Leu Val Ala Gln Phe Gly Thr Pro 
                85                  90                  95      

Leu Ile Ala Tyr Asp Glu Gly Leu Ile Arg Asp Thr Ile Arg Ala Phe 
            100                 105                 110         

His Arg Val Phe Gln Asp Glu Gly Val Pro Tyr Gln Ile Ser Tyr Ala 
        115                 120                 125             

Ser Lys Ala Phe Cys Thr Met Ala Ile Cys Gln Leu Ala His Glu Glu 
    130                 135                 140                 

Gly Leu Gly Ile Asp Val Val Ser Gly Gly Glu Leu Tyr Thr Ala Leu 
145                 150                 155                 160 

Ala Ala Gly Val Pro Ala Ser Lys Leu His Met His Gly Asn Asn Lys 
                165                 170                 175     

Thr Pro Glu Glu Leu Glu Tyr Ala Ile Glu Ser Gly Ile Gly Ala Val 
            180                 185                 190         

Ile Val Asp Asn Phe Asp Glu Ile Asp Leu Leu Ala Asp Ile Leu Gln 
        195                 200                 205             

Glu Thr Gly Arg Thr Val Asp Val Leu Val Arg Val Ala Pro Gly Val 
    210                 215                 220                 

Glu Ala His Thr His Asp Tyr Ile Ser Thr Gly Gln Gln Asp Ser Lys 
225                 230                 235                 240 

Phe Gly Phe Asp Leu Ala Ser His Gln Val Glu Glu Ala Phe Ser Arg 
                245                 250                 255     

Leu Lys Glu Val Glu Arg Ala Arg Val Ile Gly Val His Ala His Ile 
            260                 265                 270         

Gly Ser Gln Ile Phe Asp Val Glu Gly Phe Arg Leu Leu Ala Asp Arg 
        275                 280                 285             

Met Ala Gly Val Tyr Glu Asp Gly Leu Arg Arg Phe Gly Leu Pro Phe 
    290                 295                 300                 

Ser Val Leu Asn Leu Gly Gly Gly Phe Gly Ile Pro Tyr Thr Asp Glu 
305                 310                 315                 320 

Asp Ala Pro Pro Val Ala Asp Leu Val Arg Gly Val Ile Arg Ala Ala 
                325                 330                 335     

Lys Ala Ala Phe Ala Ala Arg Gly Met Asp Val Pro Val Leu Trp Ile 
            340                 345                 350         

Glu Pro Gly Arg Ser Ile Val Gly Pro Ala Gly Val Thr Leu Tyr Arg 
        355                 360                 365             

Val Gly Ser Arg Lys Val Ile Pro Gly Val Arg Asn Tyr Val Ala Ile 
    370                 375                 380                 

Asp Gly Gly Met Thr Asp Asn Pro Arg Leu Ala Leu Tyr Gly Ala Lys 
385                 390                 395                 400 

Tyr His Ala Cys Tyr Ala Asn Arg Ala Ala Asp Pro Pro Asp Arg Pro 
                405                 410                 415     

Trp Ser Val Ala Gly Lys Cys Cys Glu Ser Gly Asp Met Leu Ile Trp 
            420                 425                 430         

Asp Leu Pro Leu Pro Asp Pro Gln Pro Gly Asp Leu Leu Ala Val Phe 
        435                 440                 445             

Ala Thr Gly Ala Tyr Thr Tyr Ala Met Ala Ser His Tyr Asn Arg Ile 
    450                 455                 460                 

Pro Lys Pro Ala Val Val Phe Cys Arg Asp Gly Glu Ala Arg Leu Val 
465                 470                 475                 480 

Ala Arg Arg Glu Thr Trp Ala Asp Val Ala Arg Leu Asp Val Pro Leu 
                485                 490                 495     

Arg 
    

<210>   775
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   775
Met Phe Trp Leu Leu Pro Arg Tyr Ala Pro Gly Leu Thr Gln Phe Ala 
                5                   10                  15      

Val Ala His Val Asp Gly Ala Arg Ile Tyr Leu Cys Leu Asn Leu Tyr 
            20                  25                  30          

Ser Gly Pro Val His Arg Ser Cys Arg Arg Ala Ser Cys Lys Arg Glu 
        35                  40                  45              

Thr Ile Gly Val Asp Gly Val Lys Ser Glu His Leu Leu Asp Val Arg 
    50                  55                  60                  

Pro Arg Val Asp Ala His Phe Pro Arg Asp Glu Lys Gly His Leu Leu 
65                  70                  75                  80  

Ile Gly Gly Val Ser Ala Val Asp Leu Val Ala Gln Phe Gly Thr Pro 
                85                  90                  95      

Leu Ile Ala Tyr Asp Glu Gly Leu Ile Arg Asp Thr Ile Arg Ala Phe 
            100                 105                 110         

His Arg Val Phe Gln Asp Glu Gly Val Pro Tyr Gln Ile Ser Tyr Ala 
        115                 120                 125             

Ser Lys Ala Phe Cys Thr Met Ala Ile Cys Gln Leu Ala His Glu Glu 
    130                 135                 140                 

Gly Leu Gly Ile Asp Val Val Ser Gly Gly Glu Leu Tyr Thr Ala Leu 
145                 150                 155                 160 

Ala Ala Gly Val Pro Ala Ser Lys Leu His Met His Gly Asn Asn Lys 
                165                 170                 175     

Thr Pro Glu Glu Leu Glu Tyr Ala Ile Glu Ser Gly Ile Gly Ala Val 
            180                 185                 190         

Ile Val Asp Asn Phe Asp Glu Ile Asp Leu Leu Ala Asp Ile Leu Gln 
        195                 200                 205             

Glu Thr Gly Arg Thr Val Asp Val Leu Val Arg Val Ala Pro Gly Val 
    210                 215                 220                 

Glu Ala His Thr His Asp Tyr Ile Ser Thr Gly Gln Gln Asp Ser Lys 
225                 230                 235                 240 

Phe Gly Phe Asp Leu Ala Ser His Gln Val Glu Glu Ala Phe Ser Arg 
                245                 250                 255     

Leu Lys Glu Val Glu Arg Ala Arg Val Ile Gly Val His Ala His Ile 
            260                 265                 270         

Gly Ser Gln Ile Phe Asp Val Glu Gly Phe Arg Leu Leu Ala Asp Arg 
        275                 280                 285             

Met Ala Gly Val Tyr Glu Asp Gly Leu Arg Arg Phe Gly Leu Pro Phe 
    290                 295                 300                 

Ser Val Leu Asn Leu Gly Gly Gly Phe Gly Ile Pro Tyr Thr Asp Glu 
305                 310                 315                 320 

Asp Ala Pro Pro Val Ala Asp Leu Val Arg Gly Val Ile Arg Ala Ala 
                325                 330                 335     

Lys Ala Ala Phe Ala Ala Lys Gly Met Asp Val Pro Val Leu Trp Ile 
            340                 345                 350         

Glu Pro Gly Arg Ser Ile Val Gly Pro Ala Gly Val Thr Leu Tyr Arg 
        355                 360                 365             

Val Gly Ser Arg Lys Val Ile Pro Gly Val Arg Asn Tyr Val Ala Ile 
    370                 375                 380                 

Asp Gly Gly Met Thr Asp Asn Pro Arg Leu Ala Leu Tyr Gly Ala Lys 
385                 390                 395                 400 

Tyr His Ala Cys Tyr Ala Asn Arg Ala Ala Asp Pro Pro Asp Arg Pro 
                405                 410                 415     

Trp Ser Val Ala Gly Lys Cys Cys Glu Ser Gly Asp Met Leu Ile Trp 
            420                 425                 430         

Asp Leu Pro Leu Pro Asp Pro Gln Pro Gly Asp Leu Leu Ala Val Phe 
        435                 440                 445             

Ala Thr Gly Ala Tyr Thr Tyr Ala Met Ala Ser His Tyr Asn Arg Ile 
    450                 455                 460                 

Pro Lys Pro Ala Val Val Phe Cys Arg Asp Gly Glu Ala Arg Leu Val 
465                 470                 475                 480 

Ala Arg Arg Glu Thr Trp Ala Asp Val Ala Arg Leu Asp Val Pro Leu 
                485                 490                 495     

Arg 
    

<210>   776
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   776
Met Phe Trp Leu Leu Pro Arg Tyr Ala Pro Gly Leu Thr Gln Phe Ala 
                5                   10                  15      

Val Ala His Val Asp Gly Ala Lys Ile Tyr Leu Cys Leu Asn Leu Tyr 
            20                  25                  30          

Ser Gly Pro Val His Arg Ser Cys Arg Arg Ala Ser Cys Lys Arg Glu 
        35                  40                  45              

Thr Ile Gly Val Asp Gly Val Lys Ser Glu His Leu Leu Asp Val Arg 
    50                  55                  60                  

Pro Arg Val Asp Ala His Phe Pro Arg Asp Glu Lys Gly His Leu Leu 
65                  70                  75                  80  

Ile Gly Gly Val Ser Ala Val Asp Leu Val Ala Gln Phe Gly Thr Pro 
                85                  90                  95      

Leu Ile Ala Tyr Asp Glu Gly Leu Ile Arg Asp Thr Ile Arg Ala Phe 
            100                 105                 110         

His Arg Val Phe Gln Asp Glu Gly Val Pro Tyr Gln Ile Ser Tyr Ala 
        115                 120                 125             

Ser Lys Ala Phe Cys Thr Met Ala Ile Cys Gln Leu Ala His Glu Glu 
    130                 135                 140                 

Gly Leu Gly Ile Asp Val Val Ser Gly Gly Glu Leu Tyr Thr Ala Leu 
145                 150                 155                 160 

Ala Ala Gly Val Pro Ala Ser Lys Leu His Met His Gly Asn Asn Lys 
                165                 170                 175     

Thr Pro Glu Glu Leu Glu Tyr Ala Ile Glu Ser Gly Ile Gly Ala Val 
            180                 185                 190         

Ile Val Asp Asn Phe Asp Glu Ile Asp Leu Leu Ala Asp Ile Leu Gln 
        195                 200                 205             

Glu Thr Gly Arg Thr Val Asp Val Leu Val Arg Val Ala Pro Gly Val 
    210                 215                 220                 

Glu Ala His Thr His Asp Tyr Ile Ser Thr Gly Gln Gln Asp Ser Lys 
225                 230                 235                 240 

Phe Gly Phe Asp Leu Ala Ser His Gln Val Glu Glu Ala Phe Ser Arg 
                245                 250                 255     

Leu Lys Glu Val Glu Arg Ala Arg Val Ile Gly Val His Ala His Ile 
            260                 265                 270         

Gly Ser Gln Ile Phe Asp Val Glu Gly Phe Arg Leu Leu Ala Asp Arg 
        275                 280                 285             

Met Ala Gly Val Tyr Glu Asp Gly Leu Arg Arg Phe Gly Leu Pro Phe 
    290                 295                 300                 

Ser Val Leu Asn Leu Gly Gly Gly Phe Gly Ile Pro Tyr Thr Asp Glu 
305                 310                 315                 320 

Asp Ala Pro Pro Val Ala Asp Leu Val Arg Gly Val Ile Arg Ala Ala 
                325                 330                 335     

Lys Ala Ala Phe Ala Ala Arg Gly Met Asp Val Pro Val Leu Trp Ile 
            340                 345                 350         

Glu Pro Gly Arg Ser Ile Val Gly Pro Ala Gly Val Thr Leu Tyr Arg 
        355                 360                 365             

Val Gly Ser Arg Lys Val Ile Pro Gly Val Arg Asn Tyr Val Ala Ile 
    370                 375                 380                 

Asp Gly Gly Met Thr Asp Asn Pro Arg Leu Ala Leu Tyr Gly Ala Lys 
385                 390                 395                 400 

Tyr His Ala Cys Tyr Ala Asn Arg Ala Ala Asp Pro Pro Asp Arg Pro 
                405                 410                 415     

Trp Ser Val Ala Gly Lys Cys Cys Glu Ser Gly Asp Met Leu Ile Trp 
            420                 425                 430         

Asp Leu Pro Leu Pro Asp Pro Gln Pro Gly Asp Leu Leu Ala Val Phe 
        435                 440                 445             

Ala Thr Gly Ala Tyr Thr Tyr Ala Met Ala Ser His Tyr Asn Arg Ile 
    450                 455                 460                 

Pro Lys Pro Ala Val Val Phe Cys Arg Asp Gly Glu Ala Arg Leu Val 
465                 470                 475                 480 

Ala Arg Arg Glu Thr Trp Ala Asp Val Ala Arg Leu Asp Val Pro Leu 
                485                 490                 495     

Arg 
    

<210>   777
<211>   497
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   777
Met Phe Trp Leu Leu Pro Arg Tyr Ala Pro Gly Leu Thr Gln Phe Ala 
                5                   10                  15      

Val Ala His Val Asp Gly Ala Arg Ile Tyr Leu Cys Leu Asn Leu Tyr 
            20                  25                  30          

Ser Gly Pro Val His Arg Ser Cys Arg Arg Ala Ser Cys Lys Arg Glu 
        35                  40                  45              

Thr Ile Gly Val Asp Gly Val Lys Ser Glu His Leu Leu Asp Val Arg 
    50                  55                  60                  

Pro Arg Val Asp Ala His Phe Pro Arg Asp Glu Lys Gly His Leu Leu 
65                  70                  75                  80  

Ile Gly Gly Val Ser Ala Val Asp Leu Val Ala Gln Phe Gly Thr Pro 
                85                  90                  95      

Leu Ile Ala Tyr Asp Glu Gly Leu Ile Arg Asp Thr Ile Arg Ala Phe 
            100                 105                 110         

His Arg Val Phe Gln Asp Glu Gly Val Pro Tyr Gln Ile Ser Tyr Ala 
        115                 120                 125             

Ser Lys Ala Phe Cys Thr Met Ala Ile Cys Gln Leu Ala His Glu Glu 
    130                 135                 140                 

Gly Leu Gly Ile Asp Val Val Ser Gly Gly Glu Leu Tyr Thr Ala Leu 
145                 150                 155                 160 

Ala Ala Gly Val Pro Ala Ser Lys Leu His Met His Gly Asn Asn Lys 
                165                 170                 175     

Thr Pro Glu Glu Leu Glu Tyr Ala Ile Glu Ser Gly Ile Gly Ala Val 
            180                 185                 190         

Ile Val Asp Asn Phe Asp Glu Ile Asp Leu Leu Ala Asp Ile Leu Gln 
        195                 200                 205             

Glu Thr Gly Arg Thr Val Asp Val Leu Val Arg Val Ala Pro Gly Val 
    210                 215                 220                 

Glu Ala His Thr His Asp Tyr Ile Ser Thr Gly Gln Gln Asp Ser Lys 
225                 230                 235                 240 

Phe Gly Phe Asp Leu Ala Ser His Gln Val Glu Glu Ala Phe Ser Arg 
                245                 250                 255     

Leu Lys Glu Ile Glu Arg Ala Arg Val Ile Gly Val His Ala His Ile 
            260                 265                 270         

Gly Ser Gln Ile Phe Asp Val Glu Gly Phe Arg Leu Leu Ala Asp Arg 
        275                 280                 285             

Met Ala Gly Val Tyr Glu Asp Gly Leu Arg Arg Phe Gly Leu Pro Phe 
    290                 295                 300                 

Ser Val Leu Asn Leu Gly Gly Gly Phe Gly Ile Pro Tyr Thr Asp Glu 
305                 310                 315                 320 

Asp Ala Pro Pro Val Ala Asp Leu Val Arg Gly Val Ile Arg Ala Ala 
                325                 330                 335     

Lys Ala Ala Phe Ala Ala Arg Gly Met Asp Val Pro Val Leu Trp Ile 
            340                 345                 350         

Glu Pro Gly Arg Ser Ile Val Gly Pro Ala Gly Val Thr Leu Tyr Arg 
        355                 360                 365             

Val Gly Ser Arg Lys Val Ile Pro Gly Val Arg Asn Tyr Val Ala Ile 
    370                 375                 380                 

Asp Gly Gly Met Thr Asp Asn Pro Arg Leu Ala Leu Tyr Gly Ala Lys 
385                 390                 395                 400 

Tyr His Ala Cys Tyr Ala Asn Arg Ala Ala Asp Pro Pro Asp Arg Pro 
                405                 410                 415     

Trp Ser Val Ala Gly Lys Cys Cys Glu Ser Gly Asp Met Leu Ile Trp 
            420                 425                 430         

Asp Leu Pro Leu Pro Asp Pro Gln Pro Gly Asp Leu Leu Ala Val Phe 
        435                 440                 445             

Ala Thr Gly Ala Tyr Thr Tyr Ala Met Ala Ser His Tyr Asn Arg Ile 
    450                 455                 460                 

Pro Lys Pro Ala Val Val Phe Cys Arg Asp Gly Glu Ala Arg Leu Val 
465                 470                 475                 480 

Ala Arg Arg Glu Thr Trp Ala Asp Val Ala Arg Leu Asp Val Pro Leu 
                485                 490                 495     

Arg 
    

<210>   778
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   778
gtgttctggc ttttaccgcg ctatgcaccg ggcttaacgc aatttgccgt tgcccacgtc       60

gatggcgcac gtatatactt gtgtctgaat ctttattcag gtcctgtaca caggtcgtgt      120

cgccgcgcgt catgcaagag agagacgata ggagtggacg gagtgaaatc agagcacctg      180

ttggacgtga ggccgagggt ggacgcgcat tttccgcgag acgaaaaggg tcatcttctc      240

atcggcgggg tgagcgcggt cgaactcgtg gcacagttcg gcacgccgct catcgcgtac      300

gacgaggggc tgattcgcga taccatccgc gcgtttcacc gcgtgtttca agacgaaggc      360

gtgccctatc agatttctta cgccagcaag gccttctgca ccatggccat ctgccaactc      420

gcgcacgagg agggcttggg catcgacgtg gtgtccggcg gcgagttgta caccgcgctc      480

gcggccggcg tgccggcgag caagctccac atgcatggca acaacaaaac gccggaggaa      540

ctcgaatacg ccattgagag cggcatcggg gccgtgatcg tggacaattt cgacgagatc      600

gatctcctgg ccgatatcct tcaagaaacc gggcgcacgg tcgatgtcct ggtgcgggtg      660

gcgccaggtg tcgaggcgca cacgcacgac tacatctcca ccgggcagca ggactccaag      720

tttggcttcg atctcgccag ccaccaggtg gaggaggcct tttcgcggct caaagaggtg      780

gaacgcgcgc gggtcatcgg cgtgcatgcg cacatcggat cgcagatctt cgatgtggag      840

ggctttcgac tgctcgccga tcgaatggcg ggcgtgtacg aagacggcct gcgccggttc      900

ggcctgccct tttccgtgct caacctgggt ggcgggtttg gcatcccgta cacggatgag      960

gatgcgccgc cggtggccga tctcgtccgg ggtgtgatcc gcgccgccaa ggcggccttt     1020

gcggcgcgag gcatggacgt gccggtgctc tggattgaac ccggccgaag catcgtcggg     1080

cccgcgggcg tgacgctgta ccgcgtgggc agtcgcaagg tcattccggg cgtgcggaat     1140

tacgtcgcca tcgacggggg catgacggac aacccgcgcc tggcgctcta tggcgcgaag     1200

taccacgcgt gttacgcaaa tcgggcggcg gatccgccgg atcgcccgtg gtcggtggcg     1260

ggcaagtgct gcgagagcgg ggacatgctc atctgggatc tcccgcttcc ggatccgcag     1320

ccgggggatc tcctcgccgt cttcgcgacc ggcgcgtaca cgtatgcgat ggcgagccac     1380

tacaaccgca ttcccaagcc cgccgtcgtg ttttgccgcg atggcgaggc gcgcctcgtg     1440

gcgcggcgcg agacgtgggc ggacgtggcg cggctcgatg tgccgcttcg gtga           1494


<210>   779
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   779
gtgttctggc ttttaccgcg ctatgcaccg ggcttaacgc aatttgccgt tgcccacgtc       60

gatggcgcac gtatatactt gtgtctgaat ctttattcag gtcctgtaca caggtcgtgt      120

cgccgcgcgt catgcaagaa agagacgata ggagtggacg gagtgaaatc agagcacctg      180

ttggacgtga ggccgagggt ggacgcgcat tttccgcgag acgaaaaggg tcatcttctc      240

atcggcgggg tgagcgcggt cgatctcgtg gcacagttcg gcacgccgct catcgcgtac      300

gacgaggggc tgattcgcga taccatccgc gcgtttcacc gcgtgtttca agacgaaggc      360

gtgccctatc agatttctta cgccagcaag gccttctgca ccatggccat ctgccaactc      420

gcgcacgagg agggcttggg catcgacgtg gtgtccggcg gcgagttgta caccgcgctc      480

gcggccggcg tgccggcgag caagctccac atgcatggca acaacaaaac gccggaggaa      540

ctcgaatacg ccattgagag cggcatcggg gccgtgatcg tggacaattt cgacgagatc      600

gatctcctgg ccgatatcct tcaagaaacc gggcgcacgg tcgatgtcct ggtgcgggtg      660

gcgccaggtg tcgaggcgca cacgcacgac tacatctcca ccgggcagca ggactccaag      720

tttggcttcg atctcgccag ccaccaggtg gaggaggcct tttcgcggct caaagaggtg      780

gaacgcgcgc gggtcatcgg cgtgcatgcg cacatcggat cgcagatctt cgatgtggag      840

ggctttcgac tgctcgccga tcgaatggcg ggcgtgtacg aagacggcct gcgccggttc      900

ggcctgccct tttccgtgct caacctgggt ggcgggtttg gcatcccgta cacggatgag      960

gatgcgccgc cggtggccga tctcgtccgg ggtgtgatcc gcgccgccaa ggcggccttt     1020

gcggcgcgag gcatggacgt gccggtgctc tggattgaac ccggccgaag catcgtcggg     1080

cccgcgggcg tgacgctgta ccgcgtgggc agtcgcaagg tcattccggg cgtgcggaat     1140

tacgtcgcca tcgacggggg catgacggac aacccgcgcc tggcgctcta tggcgcgaag     1200

taccacgcgt gttacgcaaa tcgggcggcg gatccgccgg atcgcccgtg gtcggtggcg     1260

ggcaagtgct gcgagagcgg ggacatgctc atctgggatc tcccgcttcc ggatccgcag     1320

ccgggggatc tcctcgccgt cttcgcgacc ggcgcgtaca cgtatgcgat ggcgagccac     1380

tacaaccgca ttcccaagcc cgccgtcgtg ttttgccgcg atggcgaggc gcgcctcgtg     1440

gcgcggcgcg agacgtgggc ggacgtggcg cggctcgatg tgccgcttcg gtga           1494


<210>   780
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   780
gtgttctggc ttttaccgcg ctatgcaccg ggcttaacgc aatttgccgt tgcccacgtc       60

gatggcgcac gtatatactt gtgtctgaat ctttattcag gtcctgtaca caggtcgtgt      120

cgccgcgcgt catgcaagag agagacgata ggagtggacg gagtgaaatc agagcacctg      180

ttggacgtga ggccgagggt ggacgcgcat tttccgcgag acgaaaaggg tcatcttctc      240

atcggcgggg tgagcgcggt cgatctcgtg gcacagttcg gcacgccgct catcgcgtac      300

gacgaggggc tgattcgcga taccatccgc gcgtttcacc gcgtgtttca agacgaaggc      360

gtgccctatc agatttctta cgccagcaag gccttctgca ccatggccat ctgccaactc      420

gcgcacgagg agggcttggg catcgacgtg gtgtccggcg gcgagttgta caccgcgctc      480

gcggccggcg tgccggcgag caagctccac atgcatggca acaacaaaac gccggaggaa      540

ctcgaatacg ccattgagag cggcatcggg gccgtgatcg tggacaattt cgacgagatc      600

gatctcctgg ccgatatcct tcaagaaacc gggcgcacgg tcgatgtcct ggtgcgggtg      660

gcgccaggtg tcgaggcgca cacgcacgac tacatctcca ccgggcagca ggactccaag      720

tttggcttcg atctcgccag ccaccaggtg gaggaggcct tttcgcggct caaagaggtg      780

gaacgcgcgc gggtcatcgg cgtgcatgcg cacatcggat cgcagatctt cgatgtggag      840

ggctttcgac tgctcgccga tcgaatggcg ggcgtgtacg aagacggcct gcgccggttc      900

ggcctgccct tttccgtgct caacctgggt ggcgggtttg gcatcccgta cacggatgag      960

gatgcgccgc cggtggccga tctcgtccgg ggtgtgatcc gcgccgccaa ggcggccttt     1020

gcggcgaaag gcatggacgt gccggtgctc tggattgaac ccggccgaag catcgtcggg     1080

cccgcgggcg tgacgctgta ccgcgtgggc agtcgcaagg tcattccggg cgtgcggaat     1140

tacgtcgcca tcgacggggg catgacggac aacccgcgcc tggcgctcta tggcgcgaag     1200

taccacgcgt gttacgcaaa tcgggcggcg gatccgccgg atcgcccgtg gtcggtggcg     1260

ggcaagtgct gcgagagcgg ggacatgctc atctgggatc tcccgcttcc ggatccgcag     1320

ccgggggatc tcctcgccgt cttcgcgacc ggcgcgtaca cgtatgcgat ggcgagccac     1380

tacaaccgca ttcccaagcc cgccgtcgtg ttttgccgcg atggcgaggc gcgcctcgtg     1440

gcgcggcgcg agacgtgggc ggacgtggcg cggctcgatg tgccgcttcg gtga           1494


<210>   781
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   781
gtgttctggc ttttaccgcg ctatgcaccg ggcttaacgc aatttgccgt tgcccacgtc       60

gatggcgcaa aaatatactt gtgtctgaat ctttattcag gtcctgtaca caggtcgtgt      120

cgccgcgcgt catgcaagag agagacgata ggagtggacg gagtgaaatc agagcacctg      180

ttggacgtga ggccgagggt ggacgcgcat tttccgcgag acgaaaaggg tcatcttctc      240

atcggcgggg tgagcgcggt cgatctcgtg gcacagttcg gcacgccgct catcgcgtac      300

gacgaggggc tgattcgcga taccatccgc gcgtttcacc gcgtgtttca agacgaaggc      360

gtgccctatc agatttctta cgccagcaag gccttctgca ccatggccat ctgccaactc      420

gcgcacgagg agggcttggg catcgacgtg gtgtccggcg gcgagttgta caccgcgctc      480

gcggccggcg tgccggcgag caagctccac atgcatggca acaacaaaac gccggaggaa      540

ctcgaatacg ccattgagag cggcatcggg gccgtgatcg tggacaattt cgacgagatc      600

gatctcctgg ccgatatcct tcaagaaacc gggcgcacgg tcgatgtcct ggtgcgggtg      660

gcgccaggtg tcgaggcgca cacgcacgac tacatctcca ccgggcagca ggactccaag      720

tttggcttcg atctcgccag ccaccaggtg gaggaggcct tttcgcggct caaagaggtg      780

gaacgcgcgc gggtcatcgg cgtgcatgcg cacatcggat cgcagatctt cgatgtggag      840

ggctttcgac tgctcgccga tcgaatggcg ggcgtgtacg aagacggcct gcgccggttc      900

ggcctgccct tttccgtgct caacctgggt ggcgggtttg gcatcccgta cacggatgag      960

gatgcgccgc cggtggccga tctcgtccgg ggtgtgatcc gcgccgccaa ggcggccttt     1020

gcggcgcgag gcatggacgt gccggtgctc tggattgaac ccggccgaag catcgtcggg     1080

cccgcgggcg tgacgctgta ccgcgtgggc agtcgcaagg tcattccggg cgtgcggaat     1140

tacgtcgcca tcgacggggg catgacggac aacccgcgcc tggcgctcta tggcgcgaag     1200

taccacgcgt gttacgcaaa tcgggcggcg gatccgccgg atcgcccgtg gtcggtggcg     1260

ggcaagtgct gcgagagcgg ggacatgctc atctgggatc tcccgcttcc ggatccgcag     1320

ccgggggatc tcctcgccgt cttcgcgacc ggcgcgtaca cgtatgcgat ggcgagccac     1380

tacaaccgca ttcccaagcc cgccgtcgtg ttttgccgcg atggcgaggc gcgcctcgtg     1440

gcgcggcgcg agacgtgggc ggacgtggcg cggctcgatg tgccgcttcg gtga           1494


<210>   782
<211>   1494
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   782
gtgttctggc ttttaccgcg ctatgcaccg ggcttaacgc aatttgccgt tgcccacgtc       60

gatggcgcac gtatatactt gtgtctgaat ctttattcag gtcctgtaca caggtcgtgt      120

cgccgcgcgt catgcaagag agagacgata ggagtggacg gagtgaaatc agagcacctg      180

ttggacgtga ggccgagggt ggacgcgcat tttccgcgag acgaaaaggg tcatcttctc      240

atcggcgggg tgagcgcggt cgatctcgtg gcacagttcg gcacgccgct catcgcgtac      300

gacgaggggc tgattcgcga taccatccgc gcgtttcacc gcgtgtttca agacgaaggc      360

gtgccctatc agatttctta cgccagcaag gccttctgca ccatggccat ctgccaactc      420

gcgcacgagg agggcttggg catcgacgtg gtgtccggcg gcgagttgta caccgcgctc      480

gcggccggcg tgccggcgag caagctccac atgcatggca acaacaaaac gccggaggaa      540

ctcgaatacg ccattgagag cggcatcggg gccgtgatcg tggacaattt cgacgagatc      600

gatctcctgg ccgatatcct tcaagaaacc gggcgcacgg tcgatgtcct ggtgcgggtg      660

gcgccaggtg tcgaggcgca cacgcacgac tacatctcca ccgggcagca ggactccaag      720

tttggcttcg atctcgccag ccaccaggtg gaggaggcct tttcgcggct caaagagatt      780

gaacgcgcgc gggtcatcgg cgtgcatgcg cacatcggat cgcagatctt cgatgtggag      840

ggctttcgac tgctcgccga tcgaatggcg ggcgtgtacg aagacggcct gcgccggttc      900

ggcctgccct tttccgtgct caacctgggt ggcgggtttg gcatcccgta cacggatgag      960

gatgcgccgc cggtggccga tctcgtccgg ggtgtgatcc gcgccgccaa ggcggccttt     1020

gcggcgcgag gcatggacgt gccggtgctc tggattgaac ccggccgaag catcgtcggg     1080

cccgcgggcg tgacgctgta ccgcgtgggc agtcgcaagg tcattccggg cgtgcggaat     1140

tacgtcgcca tcgacggggg catgacggac aacccgcgcc tggcgctcta tggcgcgaag     1200

taccacgcgt gttacgcaaa tcgggcggcg gatccgccgg atcgcccgtg gtcggtggcg     1260

ggcaagtgct gcgagagcgg ggacatgctc atctgggatc tcccgcttcc ggatccgcag     1320

ccgggggatc tcctcgccgt cttcgcgacc ggcgcgtaca cgtatgcgat ggcgagccac     1380

tacaaccgca ttcccaagcc cgccgtcgtg ttttgccgcg atggcgaggc gcgcctcgtg     1440

gcgcggcgcg agacgtgggc ggacgtggcg cggctcgatg tgccgcttcg gtga           1494


<210>   783
<211>   485
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   783
Met Leu Asp Leu Arg Gln Leu Ser Arg Gln Tyr Ile Ala Gly Glu Trp 
                5                   10                  15      

Arg Asp Gly Arg Ser Ser Arg Val His Arg Asp Leu Asn Pro Phe Asp 
            20                  25                  30          

Gly Ser Thr Val Ala Glu Ile Arg Leu Ala Thr Val Glu Asp Ile Asp 
        35                  40                  45              

Gln Ala Tyr Arg Ala Ala Ala Glu Ala Gln Lys Val Trp Ala Gln Val 
    50                  55                  60                  

Asn Pro Phe Glu Arg Gln Ala Val Met Glu Arg Ala Leu Gln Ile Trp 
65                  70                  75                  80  

Glu Gly Tyr Arg Asp Glu Val Ile Ser Leu Val Ala Asp Glu Ile Gly 
                85                  90                  95      

Gly Thr Phe Ile Lys Ala Ala Ile Glu Phe Glu Leu Val Lys Asn Phe 
            100                 105                 110         

Leu Arg Glu Ala Ala Thr Tyr Pro Leu Arg Met Glu Gly Arg Leu Leu 
        115                 120                 125             

Pro Ala Thr Ile Pro Gly Lys Glu Asn Arg Leu Leu Arg Leu Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Ile Leu Ser Pro Phe Asn Phe Pro Met Cys Leu Ser 
145                 150                 155                 160 

Met Arg Ala Leu Ala Pro Ala Ile Ala Cys Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Ala Ala Ile Thr Gly Gly Ala Leu Leu Ala Lys 
            180                 185                 190         

Val Phe Glu Glu Ala Gly Val Pro Lys Gly Leu Val Asn Ile Val Val 
        195                 200                 205             

Ala Asp Val Ala Glu Ile Gly Asp Ala Phe Leu Glu His Pro Ile Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Ala Val Gly Arg His Ile Ala 
225                 230                 235                 240 

Glu Val Ala Gly Arg His Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Leu Ile Val Leu Asp Asp Ala Asp Leu Asp Leu Ala Val 
            260                 265                 270         

Asp Ala Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Cys Ala Asn Arg Val Ile Ala Val Lys Asp Val Tyr Glu Arg Phe Leu 
    290                 295                 300                 

Gly Lys Phe Val Glu Arg Val Ser Lys Leu Lys Met Gly Ser Pro Arg 
305                 310                 315                 320 

Asp Pro Glu Thr Val Ile Gly Pro Leu Ile Asn Arg Arg Gln Val Glu 
                325                 330                 335     

Arg Leu Leu Ala Val Val Asp Ala Ser Ile Glu Gln Gly Ala Arg Val 
            340                 345                 350         

Ala Tyr Arg Gly Pro Val Asp Gly Asn Val Val Gly Pro Val Val Leu 
        355                 360                 365             

Ala Asp Val Gly Pro Glu Met Ala Cys Ala Lys Glu Glu Met Phe Gly 
    370                 375                 380                 

Pro Val Val Ala Val Met Pro Val Glu Asp Glu Glu Glu Ala Val Arg 
385                 390                 395                 400 

Ala Ala Asn Asp Ser Glu Tyr Gly Leu Thr Gly Ala Val Ile Thr Arg 
                405                 410                 415     

Asp Val Glu Arg Gly Val Arg Ile Ala Met Gln Val Glu Thr Gly Met 
            420                 425                 430         

Phe His Val Asn Asp Gly Thr Val Asn Asp Glu Pro Leu Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gly Ser Gly Val Gly Arg Tyr Asn Gly Gln Trp Gly 
    450                 455                 460                 

Ile Asp Glu Phe Thr Thr Leu Lys Trp Ile Ser Ile Gln Arg Glu Arg 
465                 470                 475                 480 

Arg Gln Tyr Pro Ile 
                485 

<210>   784
<211>   1458
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   784
atgctcgatc tcagacagct ctcacgtcaa tatatcgccg gtgagtggcg cgacggacgc       60

agttcccgcg tgcaccgaga tctgaatccg ttcgacggct cgacggtcgc cgaaattcgc      120

cttgccacgg tggaagacat cgaccaggcg taccgcgccg ccgcggaggc gcagaaggtc      180

tgggcgcagg tgaatccgtt tgaacgccag gcggtcatgg agcgagccct ccagatttgg      240

gagggctatc gagatgaggt gatctcgctc gtcgcggacg agatcggagg tacattcatc      300

aaggcggcca ttgagttcga actggtgaag aacttcctgc gcgaggcggc gacgtaccct      360

ctgcgcatgg aggggcggct gttgccggcg accattcccg ggaaagaaaa tcgcctgctg      420

cgcctgcctg ccggggtggt ggggatcctg agcccgttta acttcccgat gtgcttgtcg      480

atgcgcgctt tggcgcctgc catcgcgtgt ggcaacggcg ttgtcctgaa gccgcatgaa      540

gaagccgcca tcacgggtgg cgcgctgctt gcgaaggtgt tcgaggaggc gggggtgccg      600

aaggggctcg tcaacatcgt cgtggctgac gtcgcggaga tcggcgatgc gttcttggag      660

cacccgattc caagaatcat ctcgttcacc ggctccacag cggtcgggcg gcatatcgcg      720

gaggtggcgg gccggcacct gaagcgggtg acgctcgaac tgggcggcaa cagcgcgctc      780

atcgtgctcg acgatgccga tctcgacctc gccgtcgacg ccgcggtatt cagccgtttc      840

acgcatcagg gccagatttg catgtgcgcc aatcgcgtga tcgccgtgaa ggatgtgtac      900

gagcgatttc tcgggaaatt tgtcgagcgc gtgtcgaaac tgaagatggg cagtcctcga      960

gatcccgaga cggtcatcgg gccgctcatc aaccgccgcc aggtcgagcg gctgctcgcc     1020

gtcgtcgatg cgagcatcga gcagggcgct cgggtcgcct atcggggacc cgtggacgga     1080

aacgtggtgg ggccggtggt gctggccgac gtggggccgg agatggcgtg cgccaaagag     1140

gaaatgttcg gccccgtggt ggcggtcatg cccgtcgagg acgaggaaga ggcggtgcgc     1200

gcggccaacg acagcgagta cggtctgacg ggggccgtga tcacgcgcga cgtggagcgc     1260

ggcgtgcgga tcgccatgca ggtggagacg ggcatgtttc acgtaaacga cggcacggtg     1320

aacgacgagc ctctcgtggc gtttggcggc gagaagggtt cgggcgtcgg gcggtacaac     1380

ggacagtggg gtatcgacga gttcaccacg ctcaaatgga tctccattca gcgcgagcgg     1440

cgccagtacc ccatctga                                                   1458


<210>   785
<211>   484
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   785
Met Phe Asn Ile Gln Asp Leu Asn Lys Gln Tyr Ile Asp Gly Glu Trp 
                5                   10                  15      

Arg Asp Gly Lys Ser Pro Arg Val Leu Arg Asp Arg Asn Pro Tyr Asn 
            20                  25                  30          

Gln Glu Val Leu Ala Glu Phe Gln Ile Ala Thr Asp Ser Asp Val Asp 
        35                  40                  45              

Ala Ala Tyr His Ala Ala Leu Lys Ala Gln Asn Glu Trp Ala Thr Val 
    50                  55                  60                  

Asn Pro Tyr Arg Lys Arg Glu Ile Leu Glu Arg Ala Val Thr Tyr Ile 
65                  70                  75                  80  

Glu Glu His Glu Glu Glu Ile Val Ala Ile Ile Ile Asp Glu Leu Gly 
                85                  90                  95      

Gly Thr Arg Leu Lys Ala Ala Phe Glu Ile Gly Leu Val Lys Asn Met 
            100                 105                 110         

Ile Lys Glu Ala Ser Thr Phe Pro Leu Arg Met Glu Gly Lys Ile Leu 
        115                 120                 125             

Pro Ser Thr Glu Asn Gly Lys Glu Asn Arg Leu Tyr Arg Val Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Val Ile Ser Pro Phe Asn Phe Pro Phe Phe Leu Ser 
145                 150                 155                 160 

Val Lys Ser Val Ala Pro Ala Leu Gly Ala Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Thr Pro Ile Thr Gly Gly Thr Leu Ile Ala Lys 
            180                 185                 190         

Ile Phe Glu Glu Ala Gly Val Pro Lys Gly Leu Leu Asn Val Val Val 
        195                 200                 205             

Thr Glu Ile Asp Glu Ile Gly Asn Ala Phe Val Glu His Pro Ile Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Asn Val Gly Ser His Ile Gly 
225                 230                 235                 240 

Gln Leu Ala Val Lys His Phe Lys Lys Pro Leu Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Phe Leu Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala Val 
            260                 265                 270         

Gln Ala Ala Thr Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Ser Ala Asn Arg Ile Phe Val Gln Arg Asp Val Tyr Asp Glu Phe Val 
    290                 295                 300                 

Glu Arg Tyr Val Thr Lys Val Ala Ser Leu Lys Val Gly Asp Pro Arg 
305                 310                 315                 320 

Asp Pro Glu Thr Val Ile Gly Pro Val Met Asn Ser Arg Gln Ala Glu 
                325                 330                 335     

Thr Leu Lys Gln Ala Ile Glu Ser Gly Ile Ala Ala Gly Ala Lys Pro 
            340                 345                 350         

Val Leu His Gly Ala Ile Ser Gly Asn Met Val Glu Pro Thr Ile Leu 
        355                 360                 365             

Ile Asp Ala Ser Pro Glu Met Ala Ile Ala Gln Glu Glu Leu Phe Gly 
    370                 375                 380                 

Pro Val Val Cys Val Ile Pro Phe Asp Thr Glu Glu Glu Ala Val Glu 
385                 390                 395                 400 

Met Ala Asn Asp Thr Lys Tyr Gly Leu Ser Gly Ala Ile His Thr Ala 
                405                 410                 415     

Asn Val Glu Arg Gly Val Glu Ile Ala Lys Arg Ile Gln Thr Gly Met 
            420                 425                 430         

Ile His Val Asn Asp Ile Thr Ile Asn Asp Glu Pro Ile Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys His Ser Gly Leu Gly Arg Leu Asn Gly Glu Trp Ser 
    450                 455                 460                 

Leu Glu Glu Phe Thr Thr Leu Lys Trp Val Ser Val His Tyr Ser Gln 
465                 470                 475                 480 

Arg Val Phe Pro 
                

<210>   786
<211>   484
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   786
Met Ile Gln Ile Thr Asp Leu Asn Arg Gln Tyr Ile Gly Gly Glu Trp 
                5                   10                  15      

Arg Asp Gly Gln Ser Glu Ser Val Leu Ala Asp Leu Asn Pro Phe Thr 
            20                  25                  30          

His Lys Thr Ile Ala Ser Phe Arg Lys Ala Thr Arg Glu Asp Val Asp 
        35                  40                  45              

Ala Ala Tyr Lys Ala Ala Leu Glu Ala Lys Lys Lys Trp Asp Gly Val 
    50                  55                  60                  

Asn Pro Tyr Glu Lys Arg Ala Ile Leu Glu Lys Ala Ala Ala Tyr Ile 
65                  70                  75                  80  

Glu Asp Asn Arg Glu Ala Ile Val Phe Leu Ile Met Glu Glu Leu Gly 
                85                  90                  95      

Gly Thr Arg Leu Lys Ala Ala Phe Glu Ile Asp Leu Val Val Asn Met 
            100                 105                 110         

Ile Lys Glu Ala Ala Gly Phe Pro Leu Lys Met Glu Gly Lys Ile Leu 
        115                 120                 125             

Pro Ser Pro Val Asp Gly Lys Glu Asn Arg Ile Tyr Arg Ile Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Val Ile Ser Pro Phe Asn Phe Pro Phe Phe Leu Ser 
145                 150                 155                 160 

Val Lys Ser Val Ala Pro Ala Leu Gly Ala Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Thr Pro Ile Cys Gly Gly Thr Leu Ile Ala Lys 
            180                 185                 190         

Ile Phe Glu Glu Ala Gly Leu Pro Lys Gly Leu Leu Asn Val Val Val 
        195                 200                 205             

Thr Asp Ile Gly Glu Ile Gly Asp Ser Phe Val Glu His Pro Ile Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Lys Val Gly Ser Tyr Ile Gly 
225                 230                 235                 240 

Gln Leu Ala Ile Lys His Phe Lys Lys Pro Leu Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Leu Ile Val Leu Glu Asp Ala Asp Leu Glu Tyr Ala Val 
            260                 265                 270         

Asn Ala Ala Thr Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Ser Ala Asn Arg Ile Leu Val Gln Lys Glu Val Tyr Pro Glu Phe Leu 
    290                 295                 300                 

Lys Leu Phe Ser Gln Lys Val Ser Gly Leu Lys Thr Gly Asp Pro Leu 
305                 310                 315                 320 

Asp Pro Glu Thr Val Ile Gly Pro Val Ile Asn Glu Arg Gln Ala Glu 
                325                 330                 335     

His Leu Arg Lys Ser Ile Glu Lys Gly Ile Glu Glu Gly Ala Thr Pro 
            340                 345                 350         

Leu Leu Lys Gly Asp Ile Lys Gly Asn Leu Val Glu Pro Thr Ile Leu 
        355                 360                 365             

Ala Asp Val Thr Pro Asp Met Ser Val Ala Lys Glu Glu Leu Phe Gly 
    370                 375                 380                 

Pro Val Val Cys Val Met Pro Phe Glu Thr Glu Ala Asp Ala Val Glu 
385                 390                 395                 400 

Ile Ala Asn Asp Thr Pro Phe Gly Leu Ser Gly Ala Val His Thr Gly 
                405                 410                 415     

Asn Val Glu Ser Gly Val Ala Ile Ala Lys Gln Ile Glu Thr Gly Met 
            420                 425                 430         

Ile His Val Asn Asp Thr Thr Ile Asn Asp Glu Pro His Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gln Ser Gly Ile Gly Arg Leu Asn Gly Glu Trp Ser 
    450                 455                 460                 

Leu Asp Glu Phe Thr Thr Leu Lys Trp Ile Ser Val Gln His Gln Lys 
465                 470                 475                 480 

Arg Ser Phe Pro 
                

<210>   787
<211>   484
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   787
Met Phe Gln Tyr Glu Glu Leu Asn Lys Gln Phe Ile Gly Gly Arg Trp 
                5                   10                  15      

Arg Asp Gly Ser Ser Arg Asn Val Leu Glu Asn Arg Asn Pro Tyr Thr 
            20                  25                  30          

Gln Lys Val Ile Thr Ser Phe Gln Lys Ala Thr Ser Asp Asp Val Asp 
        35                  40                  45              

Ala Ala Tyr Arg Ala Ala Ala Leu Ala Lys Gln Glu Trp Asp Lys Val 
    50                  55                  60                  

Asn Pro Phe Lys Lys Arg Ala Ile Leu Glu Lys Ala Val Ser Phe Ile 
65                  70                  75                  80  

Glu Glu His Glu Glu Ala Ile Ile Tyr Leu Ile Met Glu Glu Leu Gly 
                85                  90                  95      

Gly Thr Arg Leu Lys Ala Glu Phe Glu Ile Gly Leu Val Lys Asn Met 
            100                 105                 110         

Ile Lys Glu Ala Ala Thr Phe Pro Val Arg Met Glu Gly Lys Ile Leu 
        115                 120                 125             

Pro Ser Thr Ile Asp Gly Lys Glu Asn Arg Leu Tyr Arg Ile Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Val Ile Ser Pro Phe Asn Phe Pro Phe Phe Leu Ser 
145                 150                 155                 160 

Met Lys Ser Val Ala Pro Ala Leu Gly Ala Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Thr Pro Ile Cys Gly Gly Thr Leu Ile Ala Lys 
            180                 185                 190         

Ile Phe Glu Ala Ala Gly Val Pro Asp Gly Leu Leu Asn Val Ile Val 
        195                 200                 205             

Thr Asp Ile Gly Glu Ile Gly Asp Ser Phe Val Glu His Pro Val Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Gly Val Gly Ser Tyr Ile Gly 
225                 230                 235                 240 

Gln Leu Ala Val Lys His Phe Lys Lys Pro Leu Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Leu Ile Val Leu Glu Asp Ala Asp Leu Glu Tyr Ala Val 
            260                 265                 270         

Asn Ala Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Ser Ala Asn Arg Val Leu Val His Thr Ser Val Tyr Asp Lys Phe Thr 
    290                 295                 300                 

Glu Leu Tyr Glu Ala Lys Val Ser Ser Leu Lys Val Gly Asp Pro Met 
305                 310                 315                 320 

Asp Pro Asp Thr Val Ile Gly Pro Leu Ile Asn Glu Arg Gln Ala Glu 
                325                 330                 335     

Gly Leu Arg Arg Ser Val Glu Lys Ala Ile Glu Glu Gly Ala Val Pro 
            340                 345                 350         

Val Leu Ser Gly Arg Phe Ser Gly Thr Val Ala Glu Pro Val Ile Leu 
        355                 360                 365             

Lys Asp Val Lys Pro Glu Met Ser Ile Ala Lys Glu Glu Leu Phe Gly 
    370                 375                 380                 

Pro Ala Val Cys Ile Met Thr Phe Glu Thr Glu Asp Glu Ala Val Ser 
385                 390                 395                 400 

Ile Ala Asn Ala Thr Pro Phe Gly Leu Ser Gly Ala Val His Thr Ala 
                405                 410                 415     

Asn Val Glu Arg Gly Val Glu Phe Ala Lys Arg Ile Glu Thr Gly Met 
            420                 425                 430         

Ile His Val Asn Asp Thr Thr Ile Asn Asp Glu Pro Asn Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gln Ser Gly Leu Gly Arg Leu Asn Gly Glu Trp Ser 
    450                 455                 460                 

Leu Glu Glu Phe Thr Thr Leu Lys Trp Ile Ser Val Gln His Glu Lys 
465                 470                 475                 480 

Arg Gln Phe Pro 
                

<210>   788
<211>   484
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   788
Met Phe Gln Tyr Glu Glu Leu Asn Lys Gln Phe Ile Gly Gly Lys Trp 
                5                   10                  15      

Gln Glu Gly Ser Ser Pro Asn Val Leu Glu Asn Lys Asn Pro Tyr Thr 
            20                  25                  30          

Gln Lys Thr Phe Thr Thr Phe Arg Lys Ala Thr Ala Asp Asp Val Asp 
        35                  40                  45              

Glu Ala Tyr Arg Ala Ala Ala Leu Ala Lys Lys Lys Trp Asp Ala Val 
    50                  55                  60                  

Asn Pro Phe Glu Lys Arg Thr Ile Leu Glu Lys Ala Val Thr Tyr Ile 
65                  70                  75                  80  

Glu Glu Asn Glu Glu Ala Ile Ile Tyr Leu Ile Met Glu Glu Leu Gly 
                85                  90                  95      

Gly Thr Arg Leu Lys Ala Ala Phe Glu Ile Gly Leu Val Lys Asn Ile 
            100                 105                 110         

Ile Lys Glu Ala Ala Thr Phe Pro Ile Arg Met Glu Gly Lys Ile Leu 
        115                 120                 125             

Pro Ser Thr Ile Asp Gly Lys Glu Asn Arg Leu Tyr Arg Val Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Val Ile Ser Pro Phe Asn Phe Pro Phe Phe Leu Ser 
145                 150                 155                 160 

Met Lys Ser Val Ala Pro Ala Leu Gly Ala Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Thr Pro Ile Cys Gly Gly Thr Leu Ile Ala Lys 
            180                 185                 190         

Ile Phe Glu Asn Ala Gly Ile Pro Ala Gly Leu Leu Asn Val Val Val 
        195                 200                 205             

Thr Asp Ile Ala Glu Ile Gly Asp Ser Phe Val Glu His Pro Val Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Lys Val Gly Ser Tyr Ile Gly 
225                 230                 235                 240 

Gln Leu Ala Met Lys His Phe Lys Lys Pro Leu Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Phe Ile Val Leu Glu Asp Ala Asp Ile Glu Tyr Ala Val 
            260                 265                 270         

Asn Ala Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Ser Ala Asn Arg Val Leu Val His Ser Ser Ile Tyr Asp Lys Phe Leu 
    290                 295                 300                 

Glu Leu Tyr Gln Ala Lys Val Glu Ser Leu Lys Val Gly Asp Pro Met 
305                 310                 315                 320 

Asp Pro Asp Thr Ile Ile Gly Pro Leu Ile Asn Ser Arg Gln Thr Asp 
                325                 330                 335     

Gly Leu Met Lys Thr Val Glu Gln Ala Ile Glu Glu Gly Ala Val Pro 
            340                 345                 350         

Val Lys Leu Gly Gly Phe Asn Gly Thr Ile Val Glu Pro Thr Ile Leu 
        355                 360                 365             

Lys Asp Val Lys Pro Phe Met Ser Ile Ala Lys Glu Glu Leu Phe Gly 
    370                 375                 380                 

Pro Val Val Ser Phe Met Lys Phe Asp Ser Glu Asp Glu Ala Val Asp 
385                 390                 395                 400 

Ile Ala Asn Glu Thr Pro Phe Gly Leu Ser Gly Ala Val His Thr Ser 
                405                 410                 415     

Asn Leu Glu Arg Gly Val Ala Phe Ala Lys Arg Ile Glu Thr Gly Met 
            420                 425                 430         

Ile His Val Asn Asp Thr Thr Ile Asn Asp Glu Pro Asn Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gln Ser Gly Leu Gly Arg Leu Asn Gly Glu Trp Ser 
    450                 455                 460                 

Leu Glu Glu Phe Thr Thr Leu Lys Trp Ile Ser Val Gln His Glu Lys 
465                 470                 475                 480 

Arg Ser Phe Pro 
                

<210>   789
<211>   479
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   789
Gln Leu Asp Ser Gln Tyr Ile Asn Gly Val Trp Lys Asp Gly Asn Gly 
                5                   10                  15      

Lys Ala Thr Ile Gln Asn Thr Asn Pro Tyr Ser Gly Glu Val Ile Ala 
            20                  25                  30          

Thr Tyr Arg Ala Ala Ser Leu Gln Asp Leu Asp Asp Ala Tyr Glu Thr 
        35                  40                  45              

Ala Gln Glu Val Gln Lys Ala Trp Ala Lys Glu Asn Pro Ile Thr Val 
    50                  55                  60                  

Gln Arg Ile Met Asp Lys Ala Val Thr Tyr Met Glu Glu Asn His Glu 
65                  70                  75                  80  

Glu Ile Val Asp Ile Ile Ile Gln Glu Ile Gly Gly Thr Arg Leu Lys 
                85                  90                  95      

Ala Glu Phe Glu Ile Gly Leu Val Thr Asn Met Ile Lys Glu Ala Ser 
            100                 105                 110         

Ser Phe Pro Met Arg Met Ser Gly Ser Ile Leu Pro Ser Pro Ile Asp 
        115                 120                 125             

Gly Lys Glu Asn Arg Val Tyr Arg Val Pro Val Gly Val Val Gly Val 
    130                 135                 140                 

Ile Ser Pro Phe Asn Phe Pro Phe Phe Leu Ser Met Lys Ser Val Ala 
145                 150                 155                 160 

Pro Ala Leu Ala Thr Gly Asn Ala Val Val Leu Lys Pro His Glu His 
                165                 170                 175     

Thr Ala Ile Thr Gly Gly Thr Met Ile Ala Lys Ile Phe Glu Glu Ala 
            180                 185                 190         

Gly Leu Pro Lys Gly Val Leu Gln Val Val Thr Thr Glu Ile Ser Glu 
        195                 200                 205             

Ile Gly Asp Arg Phe Val Asp His Pro Val Pro Ala Ala Ile Ser Phe 
    210                 215                 220                 

Thr Gly Ser Thr Lys Val Gly Lys His Ile Gly Glu Val Ala Ser Arg 
225                 230                 235                 240 

Asn Leu Lys Glu Val His Leu Glu Leu Gly Gly Asn Ser Ala Leu Ile 
                245                 250                 255     

Val Leu Glu Asp Ala Asp Val Asp Tyr Ala Val Ser Ala Gly Val Phe 
            260                 265                 270         

Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met Ser Ala Asn Arg Ile 
        275                 280                 285             

Ile Val His Glu Asp Val Tyr Asp Glu Phe Val Gln Lys Tyr Ala Asp 
    290                 295                 300                 

Lys Val Lys Thr Leu Thr Cys Gly Asp Pro Ala Asp Ser Ser Thr Ile 
305                 310                 315                 320 

Ile Gly Pro Leu Ile Asn Glu Arg Gln Val Gln Asn Thr Val Asn Leu 
                325                 330                 335     

Ile Glu Lys Gly Val Glu Glu Gly Ala His Pro Leu Val Arg Gly Gln 
            340                 345                 350         

Val Asn Gly Asn Val Val Glu Pro Val Ile Phe Thr Glu Val Thr Pro 
        355                 360                 365             

Asp Met Gln Ile Ala Asn Glu Glu Phe Phe Ala Pro Val Val Ala Ile 
    370                 375                 380                 

Met Lys Val Ser Ser Glu Glu Gln Ala Ile Ala Tyr Ala Asn Ala Ser 
385                 390                 395                 400 

Ser Tyr Gly Leu Ser Gly Ala Val His Thr Ser Asp Val Asn Arg Gly 
                405                 410                 415     

Ala Glu Val Ala Lys Gln Leu Glu Ser Gly Met Ile His Ile Asn Asp 
            420                 425                 430         

Gly Thr Ile Asn Asp Glu Pro Asn Val Ala Phe Gly Gly Val Lys Asn 
        435                 440                 445             

Ser Gly Val Gly Arg Leu Asn Gly Glu Trp Ser Leu Glu Ala Phe Thr 
    450                 455                 460                 

Thr Thr Lys Trp Ile Ser Ile Gln His Thr Lys Arg Gln Phe Pro 
465                 470                 475                 

<210>   790
<211>   485
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 783

<400>   790
Met Leu Asp Leu Arg Gln Leu Ser Arg Gln Tyr Ile Ala Gly Glu Trp 
                5                   10                  15      

Arg Asp Gly Arg Ser Ser Arg Val His Arg Asp Leu Asn Pro Phe Asp 
            20                  25                  30          

Gly Ser Thr Val Ala Glu Ile Arg Leu Ala Thr Val Glu Asp Ile Asp 
        35                  40                  45              

Gln Ala Tyr Arg Ala Ala Ala Glu Ala Gln Lys Val Trp Ala Gln Val 
    50                  55                  60                  

Asn Pro Phe Glu Arg Gln Ala Val Met Glu Arg Ala Leu Gln Ile Trp 
65                  70                  75                  80  

Glu Gly Tyr Arg Asp Glu Val Ile Ser Leu Val Ala Asp Glu Ile Gly 
                85                  90                  95      

Gly Thr Phe Ile Lys Ala Ala Ile Glu Phe Glu Leu Val Lys Asn Phe 
            100                 105                 110         

Leu Arg Glu Ala Ala Thr Tyr Pro Leu Arg Met Glu Gly Arg Leu Leu 
        115                 120                 125             

Pro Ala Thr Ile Pro Gly Lys Glu Asn Arg Leu Leu Arg Leu Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Ile Leu Ser Pro Phe Asn Phe Pro Met Cys Leu Ser 
145                 150                 155                 160 

Met Arg Ala Leu Ala Pro Ala Ile Ala Cys Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Ala Ala Ile Thr Gly Gly Ala Leu Leu Ala Lys 
            180                 185                 190         

Val Phe Glu Glu Ala Gly Val Pro Lys Gly Leu Val Asn Ile Val Val 
        195                 200                 205             

Ala Asp Val Ala Glu Ile Gly Asp Ala Phe Leu Glu His Pro Ile Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Ala Val Gly Arg His Ile Ala 
225                 230                 235                 240 

Glu Val Ala Gly Arg His Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Leu Ile Val Leu Asp Asp Ala Asp Leu Asp Leu Ala Val 
            260                 265                 270         

Asp Ala Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Cys Ala Asn Arg Val Ile Ala Val Lys Asp Val Tyr Glu Arg Phe Leu 
    290                 295                 300                 

Gly Lys Phe Val Glu Arg Val Ser Lys Leu Lys Met Gly Ser Pro Arg 
305                 310                 315                 320 

Asp Pro Glu Thr Val Ile Gly Pro Leu Ile Asn Arg Arg Gln Val Glu 
                325                 330                 335     

Arg Leu Leu Ala Val Val Asp Ala Ser Ile Glu Gln Gly Ala Arg Val 
            340                 345                 350         

Ala Tyr Arg Gly Pro Val Asp Gly Asn Val Val Gly Pro Val Val Leu 
        355                 360                 365             

Ala Asp Val Gly Pro Glu Met Ala Cys Ala Lys Glu Glu Met Phe Gly 
    370                 375                 380                 

Pro Val Val Ala Val Met Pro Val Glu Asp Glu Glu Glu Ala Val Arg 
385                 390                 395                 400 

Ala Ala Asn Asp Ser Glu Tyr Gly Leu Thr Gly Ala Val Ile Thr Arg 
                405                 410                 415     

Asp Val Glu Arg Gly Val Arg Ile Ala Met Gln Val Glu Thr Gly Met 
            420                 425                 430         

Phe His Val Asn Asp Gly Thr Val Asn Asp Glu Pro Ile Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gly Ser Gly Val Gly Arg Tyr Asn Gly Gln Trp Gly 
    450                 455                 460                 

Ile Asp Glu Phe Thr Thr Leu Lys Trp Ile Ser Ile Gln Arg Glu Arg 
465                 470                 475                 480 

Arg Gln Tyr Pro Ile 
                485 

<210>   791
<211>   485
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 783

<400>   791
Met Leu Asp Leu Arg Gln Leu Ser Arg Gln Tyr Ile Ala Gly Glu Trp 
                5                   10                  15      

Arg Asp Gly Arg Ser Ser Arg Val His Arg Asp Leu Asn Pro Phe Asp 
            20                  25                  30          

Gly Ser Thr Val Ala Glu Ile Arg Leu Ala Thr Val Glu Asp Ile Asp 
        35                  40                  45              

Gln Ala Tyr Arg Ala Ala Ala Glu Ala Gln Lys Val Trp Ala Gln Val 
    50                  55                  60                  

Asn Pro Phe Glu Arg Gln Ala Val Met Glu Arg Ala Leu Gln Ile Trp 
65                  70                  75                  80  

Glu Gly Tyr Arg Asp Glu Val Ile Ser Leu Val Ala Asp Glu Ile Gly 
                85                  90                  95      

Gly Thr Phe Ile Lys Ala Ala Ile Glu Phe Glu Leu Val Lys Asn Phe 
            100                 105                 110         

Leu Arg Glu Ala Ala Thr Tyr Pro Leu Arg Met Glu Gly Arg Leu Leu 
        115                 120                 125             

Pro Ala Thr Ile Pro Gly Lys Glu Asn Arg Leu Leu Arg Leu Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Ile Leu Ser Pro Phe Asn Phe Pro Met Cys Leu Ser 
145                 150                 155                 160 

Met Arg Ala Leu Ala Pro Ala Ile Ala Cys Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Ala Ala Ile Thr Gly Gly Ala Leu Leu Ala Lys 
            180                 185                 190         

Val Phe Glu Glu Ala Gly Val Pro Lys Gly Leu Val Asn Ile Val Val 
        195                 200                 205             

Ala Asp Val Ala Glu Ile Gly Asp Ala Phe Leu Glu His Pro Ile Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Ala Val Gly Arg His Ile Ala 
225                 230                 235                 240 

Glu Val Ala Gly Arg His Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Leu Ile Val Leu Asp Asp Ala Asp Leu Asp Leu Ala Val 
            260                 265                 270         

Asp Ala Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Cys Ala Asn Arg Val Ile Ala Val Lys Asp Val Tyr Glu Arg Phe Leu 
    290                 295                 300                 

Gly Arg Phe Val Glu Arg Val Ser Lys Leu Lys Met Gly Ser Pro Arg 
305                 310                 315                 320 

Asp Pro Glu Thr Val Ile Gly Pro Leu Ile Asn Arg Arg Gln Val Glu 
                325                 330                 335     

Arg Leu Leu Ala Val Val Asp Ala Ser Ile Glu Gln Gly Ala Arg Val 
            340                 345                 350         

Ala Tyr Arg Gly Pro Val Asp Gly Asn Val Val Gly Pro Val Val Leu 
        355                 360                 365             

Ala Asp Val Gly Pro Glu Met Ala Cys Ala Lys Glu Glu Met Phe Gly 
    370                 375                 380                 

Pro Val Val Ala Val Met Pro Val Glu Asp Glu Glu Glu Ala Val Arg 
385                 390                 395                 400 

Ala Ala Asn Asp Ser Glu Tyr Gly Leu Thr Gly Ala Val Ile Thr Arg 
                405                 410                 415     

Asp Val Glu Arg Gly Val Arg Ile Ala Met Gln Val Glu Thr Gly Met 
            420                 425                 430         

Phe His Val Asn Asp Gly Thr Val Asn Asp Glu Pro Leu Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gly Ser Gly Val Gly Arg Tyr Asn Gly Gln Trp Gly 
    450                 455                 460                 

Ile Asp Glu Phe Thr Thr Leu Lys Trp Ile Ser Ile Gln Arg Glu Arg 
465                 470                 475                 480 

Arg Gln Tyr Pro Ile 
                485 

<210>   792
<211>   485
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 783

<400>   792
Met Leu Asp Leu Arg Gln Leu Ser Arg Gln Tyr Ile Ala Gly Glu Trp 
                5                   10                  15      

Arg Asp Gly Arg Ser Ser Arg Val His Arg Asp Leu Asn Pro Phe Asp 
            20                  25                  30          

Gly Ser Thr Val Ala Glu Ile Arg Leu Ala Thr Val Glu Asp Ile Asp 
        35                  40                  45              

Gln Ala Tyr Arg Ala Ala Ala Glu Ala Gln Lys Val Trp Ala Gln Ile 
    50                  55                  60                  

Asn Pro Phe Glu Arg Gln Ala Val Met Glu Arg Ala Leu Gln Ile Trp 
65                  70                  75                  80  

Glu Gly Tyr Arg Asp Glu Val Ile Ser Leu Val Ala Asp Glu Ile Gly 
                85                  90                  95      

Gly Thr Phe Ile Lys Ala Ala Ile Glu Phe Glu Leu Val Lys Asn Phe 
            100                 105                 110         

Leu Arg Glu Ala Ala Thr Tyr Pro Leu Arg Met Glu Gly Arg Leu Leu 
        115                 120                 125             

Pro Ala Thr Ile Pro Gly Lys Glu Asn Arg Leu Leu Arg Leu Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Ile Leu Ser Pro Phe Asn Phe Pro Met Cys Leu Ser 
145                 150                 155                 160 

Met Arg Ala Leu Ala Pro Ala Ile Ala Cys Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Ala Ala Ile Thr Gly Gly Ala Leu Leu Ala Lys 
            180                 185                 190         

Val Phe Glu Glu Ala Gly Val Pro Lys Gly Leu Val Asn Ile Val Val 
        195                 200                 205             

Ala Asp Val Ala Glu Ile Gly Asp Ala Phe Leu Glu His Pro Ile Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Ala Val Gly Arg His Ile Ala 
225                 230                 235                 240 

Glu Val Ala Gly Arg His Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Leu Ile Val Leu Asp Asp Ala Asp Leu Asp Leu Ala Val 
            260                 265                 270         

Asp Ala Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Cys Ala Asn Arg Val Ile Ala Val Lys Asp Val Tyr Glu Arg Phe Leu 
    290                 295                 300                 

Gly Lys Phe Val Glu Arg Val Ser Lys Leu Lys Met Gly Ser Pro Arg 
305                 310                 315                 320 

Asp Pro Glu Thr Val Ile Gly Pro Leu Ile Asn Arg Arg Gln Val Glu 
                325                 330                 335     

Arg Leu Leu Ala Val Val Asp Ala Ser Ile Glu Gln Gly Ala Arg Val 
            340                 345                 350         

Ala Tyr Arg Gly Pro Val Asp Gly Asn Val Val Gly Pro Val Val Leu 
        355                 360                 365             

Ala Asp Val Gly Pro Glu Met Ala Cys Ala Lys Glu Glu Met Phe Gly 
    370                 375                 380                 

Pro Val Val Ala Val Met Pro Val Glu Asp Glu Glu Glu Ala Val Arg 
385                 390                 395                 400 

Ala Ala Asn Asp Ser Glu Tyr Gly Leu Thr Gly Ala Val Ile Thr Arg 
                405                 410                 415     

Asp Val Glu Arg Gly Val Arg Ile Ala Met Gln Val Glu Thr Gly Met 
            420                 425                 430         

Phe His Val Asn Asp Gly Thr Val Asn Asp Glu Pro Leu Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gly Ser Gly Val Gly Arg Tyr Asn Gly Gln Trp Gly 
    450                 455                 460                 

Ile Asp Glu Phe Thr Thr Leu Lys Trp Ile Ser Ile Gln Arg Glu Arg 
465                 470                 475                 480 

Arg Gln Tyr Pro Ile 
                485 

<210>   793
<211>   485
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 783

<400>   793
Met Leu Asp Leu Arg Gln Leu Ser Arg Gln Tyr Ile Ala Gly Glu Trp 
                5                   10                  15      

Arg Asp Gly Arg Ser Ser Arg Val His Arg Asp Leu Asn Pro Phe Asp 
            20                  25                  30          

Gly Ser Thr Val Ala Glu Ile Arg Leu Ala Thr Val Glu Asp Ile Asp 
        35                  40                  45              

Gln Ala Tyr Arg Ala Ala Ala Glu Ala Gln Lys Val Trp Ala Gln Val 
    50                  55                  60                  

Asn Pro Phe Glu Arg Gln Ala Val Met Glu Arg Ala Leu Gln Ile Trp 
65                  70                  75                  80  

Glu Gly Tyr Arg Asp Glu Val Ile Ser Leu Val Ala Asp Glu Ile Gly 
                85                  90                  95      

Gly Thr Phe Ile Lys Ala Ala Ile Glu Phe Glu Leu Val Lys Asn Phe 
            100                 105                 110         

Leu Arg Glu Ala Ala Thr Tyr Pro Leu Arg Met Glu Gly Arg Leu Leu 
        115                 120                 125             

Pro Ala Thr Leu Pro Gly Lys Glu Asn Arg Leu Leu Arg Leu Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Ile Leu Ser Pro Phe Asn Phe Pro Met Cys Leu Ser 
145                 150                 155                 160 

Met Arg Ala Leu Ala Pro Ala Ile Ala Cys Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Ala Ala Ile Thr Gly Gly Ala Leu Leu Ala Lys 
            180                 185                 190         

Val Phe Glu Glu Ala Gly Val Pro Lys Gly Leu Val Asn Ile Val Val 
        195                 200                 205             

Ala Asp Val Ala Glu Ile Gly Asp Ala Phe Leu Glu His Pro Ile Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Ala Val Gly Arg His Ile Ala 
225                 230                 235                 240 

Glu Val Ala Gly Arg His Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Leu Ile Val Leu Asp Asp Ala Asp Leu Asp Leu Ala Val 
            260                 265                 270         

Asp Ala Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Cys Ala Asn Arg Val Ile Ala Val Lys Asp Val Tyr Glu Arg Phe Leu 
    290                 295                 300                 

Gly Lys Phe Val Glu Arg Val Ser Lys Leu Lys Met Gly Ser Pro Arg 
305                 310                 315                 320 

Asp Pro Glu Thr Val Ile Gly Pro Leu Ile Asn Arg Arg Gln Val Glu 
                325                 330                 335     

Arg Leu Leu Ala Val Val Asp Ala Ser Ile Glu Gln Gly Ala Arg Val 
            340                 345                 350         

Ala Tyr Arg Gly Pro Val Asp Gly Asn Val Val Gly Pro Val Val Leu 
        355                 360                 365             

Ala Asp Val Gly Pro Glu Met Ala Cys Ala Lys Glu Glu Met Phe Gly 
    370                 375                 380                 

Pro Val Val Ala Val Met Pro Val Glu Asp Glu Glu Glu Ala Val Arg 
385                 390                 395                 400 

Ala Ala Asn Asp Ser Glu Tyr Gly Leu Thr Gly Ala Val Ile Thr Arg 
                405                 410                 415     

Asp Val Glu Arg Gly Val Arg Ile Ala Met Gln Val Glu Thr Gly Met 
            420                 425                 430         

Phe His Val Asn Asp Gly Thr Val Asn Asp Glu Pro Leu Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gly Ser Gly Val Gly Arg Tyr Asn Gly Gln Trp Gly 
    450                 455                 460                 

Ile Asp Glu Phe Thr Thr Leu Lys Trp Ile Ser Ile Gln Arg Glu Arg 
465                 470                 475                 480 

Arg Gln Tyr Pro Ile 
                485 

<210>   794
<211>   485
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 783

<400>   794
Met Leu Asp Leu Arg Gln Leu Ser Arg Gln Tyr Ile Ala Gly Glu Trp 
                5                   10                  15      

Arg Asp Gly Arg Ser Ser Arg Val His Arg Asp Leu Asn Pro Phe Asp 
            20                  25                  30          

Gly Ser Thr Val Ala Glu Ile Arg Leu Ala Thr Val Glu Asp Ile Asp 
        35                  40                  45              

Gln Ala Tyr Arg Ala Ala Ala Glu Ala Gln Lys Val Trp Ala Gln Val 
    50                  55                  60                  

Asn Pro Phe Glu Arg Gln Ala Val Met Glu Arg Ala Leu Gln Ile Trp 
65                  70                  75                  80  

Glu Gly Tyr Arg Asp Glu Val Ile Ser Leu Val Ala Asp Glu Ile Gly 
                85                  90                  95      

Gly Thr Phe Ile Lys Ala Ala Ile Glu Phe Glu Leu Val Lys Asn Phe 
            100                 105                 110         

Leu Arg Glu Ala Ala Thr Tyr Pro Leu Arg Met Glu Gly Arg Leu Leu 
        115                 120                 125             

Pro Ala Thr Ile Pro Gly Lys Glu Asn Arg Leu Leu Arg Leu Pro Ala 
    130                 135                 140                 

Gly Val Val Gly Ile Leu Ser Pro Phe Asn Phe Pro Met Cys Leu Ser 
145                 150                 155                 160 

Met Arg Ala Leu Ala Pro Ala Ile Ala Cys Gly Asn Gly Val Val Leu 
                165                 170                 175     

Lys Pro His Glu Glu Ala Ala Ile Thr Gly Gly Ala Leu Leu Ala Lys 
            180                 185                 190         

Val Phe Glu Glu Ala Gly Val Pro Lys Gly Leu Val Asn Ile Val Val 
        195                 200                 205             

Ala Asp Val Ala Glu Ile Gly Asp Ala Phe Leu Glu His Pro Ile Pro 
    210                 215                 220                 

Arg Ile Ile Ser Phe Thr Gly Ser Thr Ala Val Gly Arg His Ile Ala 
225                 230                 235                 240 

Glu Val Ala Gly Arg His Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
                245                 250                 255     

Asn Ser Ala Leu Ile Val Leu Asp Asp Ala Asp Leu Asp Leu Ala Val 
            260                 265                 270         

Asp Ala Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met 
        275                 280                 285             

Cys Ala Asn Arg Val Ile Ala Val Lys Asp Val Tyr Glu Arg Phe Leu 
    290                 295                 300                 

Gly Lys Phe Val Glu Arg Val Ser Lys Leu Lys Met Gly Ser Pro Arg 
305                 310                 315                 320 

Asp Pro Glu Thr Val Ile Gly Pro Leu Ile Asn Arg Arg Gln Val Glu 
                325                 330                 335     

Lys Leu Leu Ala Val Val Asp Ala Ser Ile Glu Gln Gly Ala Arg Val 
            340                 345                 350         

Ala Tyr Arg Gly Pro Val Asp Gly Asn Val Val Gly Pro Val Val Leu 
        355                 360                 365             

Ala Asp Val Gly Pro Glu Met Ala Cys Ala Lys Glu Glu Met Phe Gly 
    370                 375                 380                 

Pro Val Val Ala Val Met Pro Val Glu Asp Glu Glu Glu Ala Val Arg 
385                 390                 395                 400 

Ala Ala Asn Asp Ser Glu Tyr Gly Leu Thr Gly Ala Val Ile Thr Arg 
                405                 410                 415     

Asp Val Glu Arg Gly Val Arg Ile Ala Met Gln Val Glu Thr Gly Met 
            420                 425                 430         

Phe His Val Asn Asp Gly Thr Val Asn Asp Glu Pro Leu Val Ala Phe 
        435                 440                 445             

Gly Gly Glu Lys Gly Ser Gly Val Gly Arg Tyr Asn Gly Gln Trp Gly 
    450                 455                 460                 

Ile Asp Glu Phe Thr Thr Leu Lys Trp Ile Ser Ile Gln Arg Glu Arg 
465                 470                 475                 480 

Arg Gln Tyr Pro Ile 
                485 

<210>   795
<211>   1458
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 784

<400>   795
atgctcgatc tcagacagct ctcacgtcaa tatatcgccg gtgagtggcg cgacggacgc       60

agttcccgcg tgcaccgaga tctgaatccg ttcgacggct cgacggtcgc cgaaattcgc      120

cttgccacgg tggaagacat cgaccaggcg taccgcgccg ccgcggaggc gcagaaggtc      180

tgggcgcagg tgaatccgtt tgaacgccag gcggtcatgg agcgagccct ccagatttgg      240

gagggctatc gagatgaggt gatctcgctc gtcgcggacg agatcggagg tacattcatc      300

aaggcggcca ttgagttcga actggtgaag aacttcctgc gcgaggcggc gacgtaccct      360

ctgcgcatgg aggggcggct gttgccggcg accattcccg ggaaagaaaa tcgcctgctg      420

cgcctgcctg ccggggtggt ggggatcctg agcccgttta acttcccgat gtgcttgtcg      480

atgcgcgctt tggcgcctgc catcgcgtgt ggcaacggcg ttgtcctgaa gccgcatgaa      540

gaagccgcca tcacgggtgg cgcgctgctt gcgaaggtgt tcgaggaggc gggggtgccg      600

aaggggctcg tcaacatcgt cgtggctgac gtcgcggaga tcggcgatgc gttcttggag      660

cacccgattc caagaatcat ctcgttcacc ggctccacag cggtcgggcg gcatatcgcg      720

gaggtggcgg gccggcacct gaagcgggtg acgctcgaac tgggcggcaa cagcgcgctc      780

atcgtgctcg acgatgccga tctcgacctc gccgtcgacg ccgcggtatt cagccgtttc      840

acgcatcagg gccagatttg catgtgcgcc aatcgcgtga tcgccgtgaa ggatgtgtac      900

gagcgatttc tcgggaaatt tgtcgagcgc gtgtcgaaac tgaagatggg cagtcctcga      960

gatcccgaga cggtcatcgg gccgctcatc aaccgccgcc aggtcgagcg gctgctcgcc     1020

gtcgtcgatg cgagcatcga gcagggcgct cgggtcgcct atcggggacc cgtggacgga     1080

aacgtggtgg ggccggtggt gctggccgac gtggggccgg agatggcgtg cgccaaagag     1140

gaaatgttcg gccccgtggt ggcggtcatg cccgtcgagg acgaggaaga ggcggtgcgc     1200

gcggccaacg acagcgagta cggtctgacg ggggccgtga tcacgcgcga cgtggagcgc     1260

ggcgtgcgga tcgccatgca ggtggagacg ggcatgtttc acgtaaacga cggcacggtg     1320

aacgacgagc ctattgtggc gtttggcggc gagaagggtt cgggcgtcgg gcggtacaac     1380

ggacagtggg gtatcgacga gttcaccacg ctcaaatgga tctccattca gcgcgagcgg     1440

cgccagtacc ccatctga                                                   1458


<210>   796
<211>   1458
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 784

<400>   796
atgctcgatc tcagacagct ctcacgtcaa tatatcgccg gtgagtggcg cgacggacgc       60

agttcccgcg tgcaccgaga tctgaatccg ttcgacggct cgacggtcgc cgaaattcgc      120

cttgccacgg tggaagacat cgaccaggcg taccgcgccg ccgcggaggc gcagaaggtc      180

tgggcgcagg tgaatccgtt tgaacgccag gcggtcatgg agcgagccct ccagatttgg      240

gagggctatc gagatgaggt gatctcgctc gtcgcggacg agatcggagg tacattcatc      300

aaggcggcca ttgagttcga actggtgaag aacttcctgc gcgaggcggc gacgtaccct      360

ctgcgcatgg aggggcggct gttgccggcg accattcccg ggaaagaaaa tcgcctgctg      420

cgcctgcctg ccggggtggt ggggatcctg agcccgttta acttcccgat gtgcttgtcg      480

atgcgcgctt tggcgcctgc catcgcgtgt ggcaacggcg ttgtcctgaa gccgcatgaa      540

gaagccgcca tcacgggtgg cgcgctgctt gcgaaggtgt tcgaggaggc gggggtgccg      600

aaggggctcg tcaacatcgt cgtggctgac gtcgcggaga tcggcgatgc gttcttggag      660

cacccgattc caagaatcat ctcgttcacc ggctccacag cggtcgggcg gcatatcgcg      720

gaggtggcgg gccggcacct gaagcgggtg acgctcgaac tgggcggcaa cagcgcgctc      780

atcgtgctcg acgatgccga tctcgacctc gccgtcgacg ccgcggtatt cagccgtttc      840

acgcatcagg gccagatttg catgtgcgcc aatcgcgtga tcgccgtgaa ggatgtgtac      900

gagcgatttc tcgggcgttt tgtcgagcgc gtgtcgaaac tgaagatggg cagtcctcga      960

gatcccgaga cggtcatcgg gccgctcatc aaccgccgcc aggtcgagcg gctgctcgcc     1020

gtcgtcgatg cgagcatcga gcagggcgct cgggtcgcct atcggggacc cgtggacgga     1080

aacgtggtgg ggccggtggt gctggccgac gtggggccgg agatggcgtg cgccaaagag     1140

gaaatgttcg gccccgtggt ggcggtcatg cccgtcgagg acgaggaaga ggcggtgcgc     1200

gcggccaacg acagcgagta cggtctgacg ggggccgtga tcacgcgcga cgtggagcgc     1260

ggcgtgcgga tcgccatgca ggtggagacg ggcatgtttc acgtaaacga cggcacggtg     1320

aacgacgagc ctctcgtggc gtttggcggc gagaagggtt cgggcgtcgg gcggtacaac     1380

ggacagtggg gtatcgacga gttcaccacg ctcaaatgga tctccattca gcgcgagcgg     1440

cgccagtacc ccatctga                                                   1458


<210>   797
<211>   1458
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 784

<400>   797
atgctcgatc tcagacagct ctcacgtcaa tatatcgccg gtgagtggcg cgacggacgc       60

agttcccgcg tgcaccgaga tctgaatccg ttcgacggct cgacggtcgc cgaaattcgc      120

cttgccacgg tggaagacat cgaccaggcg taccgcgccg ccgcggaggc gcagaaggtc      180

tgggcgcaga ttaatccgtt tgaacgccag gcggtcatgg agcgagccct ccagatttgg      240

gagggctatc gagatgaggt gatctcgctc gtcgcggacg agatcggagg tacattcatc      300

aaggcggcca ttgagttcga actggtgaag aacttcctgc gcgaggcggc gacgtaccct      360

ctgcgcatgg aggggcggct gttgccggcg accattcccg ggaaagaaaa tcgcctgctg      420

cgcctgcctg ccggggtggt ggggatcctg agcccgttta acttcccgat gtgcttgtcg      480

atgcgcgctt tggcgcctgc catcgcgtgt ggcaacggcg ttgtcctgaa gccgcatgaa      540

gaagccgcca tcacgggtgg cgcgctgctt gcgaaggtgt tcgaggaggc gggggtgccg      600

aaggggctcg tcaacatcgt cgtggctgac gtcgcggaga tcggcgatgc gttcttggag      660

cacccgattc caagaatcat ctcgttcacc ggctccacag cggtcgggcg gcatatcgcg      720

gaggtggcgg gccggcacct gaagcgggtg acgctcgaac tgggcggcaa cagcgcgctc      780

atcgtgctcg acgatgccga tctcgacctc gccgtcgacg ccgcggtatt cagccgtttc      840

acgcatcagg gccagatttg catgtgcgcc aatcgcgtga tcgccgtgaa ggatgtgtac      900

gagcgatttc tcgggaaatt tgtcgagcgc gtgtcgaaac tgaagatggg cagtcctcga      960

gatcccgaga cggtcatcgg gccgctcatc aaccgccgcc aggtcgagcg gctgctcgcc     1020

gtcgtcgatg cgagcatcga gcagggcgct cgggtcgcct atcggggacc cgtggacgga     1080

aacgtggtgg ggccggtggt gctggccgac gtggggccgg agatggcgtg cgccaaagag     1140

gaaatgttcg gccccgtggt ggcggtcatg cccgtcgagg acgaggaaga ggcggtgcgc     1200

gcggccaacg acagcgagta cggtctgacg ggggccgtga tcacgcgcga cgtggagcgc     1260

ggcgtgcgga tcgccatgca ggtggagacg ggcatgtttc acgtaaacga cggcacggtg     1320

aacgacgagc ctctcgtggc gtttggcggc gagaagggtt cgggcgtcgg gcggtacaac     1380

ggacagtggg gtatcgacga gttcaccacg ctcaaatgga tctccattca gcgcgagcgg     1440

cgccagtacc ccatctga                                                   1458


<210>   798
<211>   1458
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 784

<400>   798
atgctcgatc tcagacagct ctcacgtcaa tatatcgccg gtgagtggcg cgacggacgc       60

agttcccgcg tgcaccgaga tctgaatccg ttcgacggct cgacggtcgc cgaaattcgc      120

cttgccacgg tggaagacat cgaccaggcg taccgcgccg ccgcggaggc gcagaaggtc      180

tgggcgcagg tgaatccgtt tgaacgccag gcggtcatgg agcgagccct ccagatttgg      240

gagggctatc gagatgaggt gatctcgctc gtcgcggacg agatcggagg tacattcatc      300

aaggcggcca ttgagttcga actggtgaag aacttcctgc gcgaggcggc gacgtaccct      360

ctgcgcatgg aggggcggct gttgccggcg accttacccg ggaaagaaaa tcgcctgctg      420

cgcctgcctg ccggggtggt ggggatcctg agcccgttta acttcccgat gtgcttgtcg      480

atgcgcgctt tggcgcctgc catcgcgtgt ggcaacggcg ttgtcctgaa gccgcatgaa      540

gaagccgcca tcacgggtgg cgcgctgctt gcgaaggtgt tcgaggaggc gggggtgccg      600

aaggggctcg tcaacatcgt cgtggctgac gtcgcggaga tcggcgatgc gttcttggag      660

cacccgattc caagaatcat ctcgttcacc ggctccacag cggtcgggcg gcatatcgcg      720

gaggtggcgg gccggcacct gaagcgggtg acgctcgaac tgggcggcaa cagcgcgctc      780

atcgtgctcg acgatgccga tctcgacctc gccgtcgacg ccgcggtatt cagccgtttc      840

acgcatcagg gccagatttg catgtgcgcc aatcgcgtga tcgccgtgaa ggatgtgtac      900

gagcgatttc tcgggaaatt tgtcgagcgc gtgtcgaaac tgaagatggg cagtcctcga      960

gatcccgaga cggtcatcgg gccgctcatc aaccgccgcc aggtcgagcg gctgctcgcc     1020

gtcgtcgatg cgagcatcga gcagggcgct cgggtcgcct atcggggacc cgtggacgga     1080

aacgtggtgg ggccggtggt gctggccgac gtggggccgg agatggcgtg cgccaaagag     1140

gaaatgttcg gccccgtggt ggcggtcatg cccgtcgagg acgaggaaga ggcggtgcgc     1200

gcggccaacg acagcgagta cggtctgacg ggggccgtga tcacgcgcga cgtggagcgc     1260

ggcgtgcgga tcgccatgca ggtggagacg ggcatgtttc acgtaaacga cggcacggtg     1320

aacgacgagc ctctcgtggc gtttggcggc gagaagggtt cgggcgtcgg gcggtacaac     1380

ggacagtggg gtatcgacga gttcaccacg ctcaaatgga tctccattca gcgcgagcgg     1440

cgccagtacc ccatctga                                                   1458


<210>   799
<211>   1458
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 784

<400>   799
atgctcgatc tcagacagct ctcacgtcaa tatatcgccg gtgagtggcg cgacggacgc       60

agttcccgcg tgcaccgaga tctgaatccg ttcgacggct cgacggtcgc cgaaattcgc      120

cttgccacgg tggaagacat cgaccaggcg taccgcgccg ccgcggaggc gcagaaggtc      180

tgggcgcagg tgaatccgtt tgaacgccag gcggtcatgg agcgagccct ccagatttgg      240

gagggctatc gagatgaggt gatctcgctc gtcgcggacg agatcggagg tacattcatc      300

aaggcggcca ttgagttcga actggtgaag aacttcctgc gcgaggcggc gacgtaccct      360

ctgcgcatgg aggggcggct gttgccggcg accattcccg ggaaagaaaa tcgcctgctg      420

cgcctgcctg ccggggtggt ggggatcctg agcccgttta acttcccgat gtgcttgtcg      480

atgcgcgctt tggcgcctgc catcgcgtgt ggcaacggcg ttgtcctgaa gccgcatgaa      540

gaagccgcca tcacgggtgg cgcgctgctt gcgaaggtgt tcgaggaggc gggggtgccg      600

aaggggctcg tcaacatcgt cgtggctgac gtcgcggaga tcggcgatgc gttcttggag      660

cacccgattc caagaatcat ctcgttcacc ggctccacag cggtcgggcg gcatatcgcg      720

gaggtggcgg gccggcacct gaagcgggtg acgctcgaac tgggcggcaa cagcgcgctc      780

atcgtgctcg acgatgccga tctcgacctc gccgtcgacg ccgcggtatt cagccgtttc      840

acgcatcagg gccagatttg catgtgcgcc aatcgcgtga tcgccgtgaa ggatgtgtac      900

gagcgatttc tcgggaaatt tgtcgagcgc gtgtcgaaac tgaagatggg cagtcctcga      960

gatcccgaga cggtcatcgg gccgctcatc aaccgccgcc aggtcgagaa actgctcgcc     1020

gtcgtcgatg cgagcatcga gcagggcgct cgggtcgcct atcggggacc cgtggacgga     1080

aacgtggtgg ggccggtggt gctggccgac gtggggccgg agatggcgtg cgccaaagag     1140

gaaatgttcg gccccgtggt ggcggtcatg cccgtcgagg acgaggaaga ggcggtgcgc     1200

gcggccaacg acagcgagta cggtctgacg ggggccgtga tcacgcgcga cgtggagcgc     1260

ggcgtgcgga tcgccatgca ggtggagacg ggcatgtttc acgtaaacga cggcacggtg     1320

aacgacgagc ctctcgtggc gtttggcggc gagaagggtt cgggcgtcgg gcggtacaac     1380

ggacagtggg gtatcgacga gttcaccacg ctcaaatgga tctccattca gcgcgagcgg     1440

cgccagtacc ccatctga                                                   1458


<210>   800
<211>   370
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   800
Met Leu Ala Glu His Asp Arg Ala Glu Arg Leu Met Glu Ile Ala Lys 
                5                   10                  15      

Ala Glu Gly Leu Tyr Glu Glu Ile His Leu Leu Lys Glu Asp Gly Thr 
            20                  25                  30          

Leu Ala Gly Ala Val Asp Asp Ile Pro Pro Glu Val Met Val Ala Met 
        35                  40                  45              

Tyr Arg His Met Val Phe Ala Arg Ala Phe Asp Arg Lys Ala Ile Ala 
    50                  55                  60                  

Leu Gln Arg Gln Gly Arg Ile Gly Thr Tyr Ala Pro Phe Glu Gly Gln 
65                  70                  75                  80  

Glu Ala Ala Gln Val Ala Ser Ala Met Ala Leu Ala Pro Glu Asp Phe 
                85                  90                  95      

Val Phe Pro Ser Tyr Arg Asp His Ala Ala Thr Met Val Leu Gly Gln 
            100                 105                 110         

Ser Pro Ala Asn Val Leu Leu Tyr Trp Ser Gly Arg Val Glu Gly Ile 
        115                 120                 125             

Arg Ser Pro Glu Gly Arg His Ile Leu Pro Pro Ser Val Pro Ile Ala 
    130                 135                 140                 

Thr His Val Leu His Ala Val Gly Ala Ala Trp Ala Ser Arg Tyr Arg 
145                 150                 155                 160 

Lys Glu Ser Ala Val Ser Ile Ala Tyr Phe Gly Asp Gly Ala Thr Ser 
                165                 170                 175     

Glu Gly Asp Phe His Glu Ala Leu Asn Phe Ala Gly Val Phe His Leu 
            180                 185                 190         

Pro Val Leu Phe Phe Cys Gln Asn Asn Gly Tyr Ala Ile Ser Val Pro 
        195                 200                 205             

Phe Ser Arg Gln Ser Ala Ser Arg Thr Ile Ala Gln Arg Ala Ile Ala 
    210                 215                 220                 

Tyr Asp Ile Val Gly Val Arg Val Asp Gly Asn Asp Ala Phe Ala Val 
225                 230                 235                 240 

Tyr Arg Ala Val Lys Glu Ala Arg Ser Arg Ala Leu His Gly Leu Gly 
                245                 250                 255     

Pro Thr Leu Ile Glu Ala Val Thr Phe Arg Met Gly Ala His Thr Thr 
            260                 265                 270         

Ala Asp Asp Pro Thr Arg Tyr Arg Asp Gln Lys Ala Val Val Glu Ala 
        275                 280                 285             

Trp Gln Lys Arg Asp Pro Ile Val Arg Leu Arg Leu Tyr Leu Glu Ser 
    290                 295                 300                 

Gln Lys Leu Trp Ser Glu Ser Asp Glu Ala Lys Leu Gln Asp Glu Val 
305                 310                 315                 320 

Lys Ala Arg Val Glu Ala Ala Val Glu Glu Ala Leu Ser Ile Ala Pro 
                325                 330                 335     

Pro Asp Met Glu Met Met Phe Asp His Val Tyr Ala Glu Glu Pro Trp 
            340                 345                 350         

His Leu Ala Ala Glu Arg Glu Glu Tyr Arg Arg Thr Arg Glu Gly Val 
        355                 360                 365             

Ser Val 
    370 

<210>   801
<211>   1113
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   801
atgttggccg aacacgatcg ggcagagcgg ctcatggaaa tcgccaaggc ggaagggctg       60

tacgaggaga ttcacctcct gaaggaggac ggcacgctgg cgggtgcggt ggacgacatc      120

ccgccggagg tcatggtggc gatgtaccgc cacatggtgt tcgcccgcgc gtttgaccgg      180

aaggccatcg cgcttcagcg gcaggggcgg attggcactt acgcgccgtt cgagggccag      240

gaggccgcgc aggtggcgag cgccatggcg ctcgcgccgg aggacttcgt gttcccgtcg      300

tatcgcgatc acgccgccac gatggtgctc gggcagtcgc ccgcgaacgt gcttctctac      360

tggtcggggc gcgtggaggg catccggagc ccggagggca ggcatatcct cccacccagc      420

gtgccgattg cgacgcacgt gttgcacgcc gttggtgccg cctgggccag ccggtatcgc      480

aaggagagcg cggtcagtat cgcgtacttc ggcgacggcg cgacgagcga aggcgacttt      540

cacgaggcgc tgaatttcgc aggcgtcttc cacctgccgg tccttttctt ctgccaaaat      600

aacgggtacg ccatcagcgt gccgttctct cgccagtccg catctcgcac catcgcgcag      660

cgggcgattg cgtacgacat cgtgggcgtg cgcgtggacg gcaacgacgc gttcgcggtg      720

taccgcgccg tgaaggaggc caggtcgcgc gcgctccacg gcctcgggcc gacgctcatc      780

gaggcggtga ccttccgcat gggcgcccac accacagcgg acgatccgac gcgctaccgc      840

gatcagaagg cggtcgtgga agcgtggcag aaacgggatc cgattgtgcg cctgcgcctg      900

tacctcgagt cgcaaaagct ttggtcggaa tccgacgagg cgaagctcca ggatgaggtg      960

aaggcgcggg tggaggcggc tgtggaggag gcgctctcca tcgcgccgcc cgacatggag     1020

atgatgttcg atcacgttta cgcggaagag ccctggcacc tcgccgccga gcgcgaggag     1080

taccgcagga cccgcgaggg ggtatccgta tga                                  1113


<210>   802
<211>   337
<212>   PRT
<213>   Bacillus sp. UTB2301

<400>   802
Glu His Gln Phe Pro Lys Ile Gln Ile Val Asp Glu Asn Gly Asn Ile 
                5                   10                  15      

Val Asp Ser Lys Tyr Glu Asp Lys Leu Thr Pro Glu Phe Ile Lys Glu 
            20                  25                  30          

Leu Tyr Glu Arg Leu Met Phe Val Arg Thr Phe Asp Arg Lys Ala Ile 
        35                  40                  45              

Ser Leu Gln Arg Gln Gly Arg Leu Gly Thr Tyr Ala Pro Phe Glu Gly 
    50                  55                  60                  

Gln Glu Ala Ala Gln Val Gly Ser Ala Leu Ala Leu Glu Lys Asp Asp 
65                  70                  75                  80  

Trp Leu Phe Pro Thr Tyr Arg Asp His Ala Ala Thr Ile Thr Phe Gly 
                85                  90                  95      

His Lys Leu Ser Thr Val Phe Leu Tyr Trp Asn Gly Arg Val Glu Gly 
            100                 105                 110         

Cys Val Pro Pro Glu Gly Lys Lys Ile Phe Pro Pro Ala Val Pro Ile 
        115                 120                 125             

Ala Thr Gln Leu Pro His Ala Thr Gly Ala Ala Met Ala Glu Lys Tyr 
    130                 135                 140                 

Lys Gly Thr Lys Asn Ala Ala Ile Val Tyr Phe Gly Asp Gly Ala Thr 
145                 150                 155                 160 

Ser Glu Gly Asp Phe His Glu Gly Leu Asn Phe Ala Ser Val Phe Lys 
                165                 170                 175     

Ala Pro Val Val Phe Phe Asn Gln Asn Asn Ser Phe Ala Ile Ser Val 
            180                 185                 190         

Pro Ile His Lys Gln Met Asn Ser Lys Thr Ile Ala Gln Lys Ser Val 
        195                 200                 205             

Ala Tyr Gly Ile Pro Gly Ile Arg Leu Asp Gly Asn Asp Ile Phe Ala 
    210                 215                 220                 

Val Tyr Phe Tyr Thr Lys Glu Ala Leu Asp Arg Ala Arg Asn Gly Glu 
225                 230                 235                 240 

Gly Pro Thr Leu Ile Glu Ala Val Thr Trp Arg Tyr Gly Ala His Thr 
                245                 250                 255     

Thr Ala Asp Asp Pro Thr Lys Tyr Arg Asn Gln Glu Glu Ser Leu Glu 
            260                 265                 270         

Arg Arg Glu Lys Tyr Asp Pro Ile Leu Arg Val Glu Arg Leu Met Lys 
        275                 280                 285             

Asn Lys Gly Ile Trp Asp Glu Lys Trp Ala Ala Ser Val Glu Glu Lys 
    290                 295                 300                 

Ala Ser Gln Thr Ile Glu Glu Ala Val Lys Glu Met Glu Ala Phe Pro 
305                 310                 315                 320 

Ala Pro Asp Val Asn Asp Leu Phe Asp His Val Phe Glu Lys Pro Thr 
                325                 330                 335     

Trp 
    

<210>   803
<211>   311
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   803
Val Leu Ser Met Tyr Lys Gln Met Ile Asn Cys Arg Glu Phe Asp Glu 
                5                   10                  15      

Lys Ala Leu Lys Leu Gln Arg Gln Gly Arg Ile Gly Thr Tyr Ala Ser 
            20                  25                  30          

Phe Lys Gly Gln Glu Ala Cys Gln Ile Gly Gly Ala Leu Ala Leu Arg 
        35                  40                  45              

Pro Thr Asp Trp Leu Phe Pro Thr Tyr Arg Asp His Ala Ala Ile Ser 
    50                  55                  60                  

Thr His Gly Gln Pro Trp His Arg Ile Phe Leu Tyr Trp Met Gly His 
65                  70                  75                  80  

Met Asp Gly Ser Leu Ser Pro Asp Asp Arg Asn Ile Leu Pro Pro Ala 
                85                  90                  95      

Val Pro Ile Ala Thr Gln Met Leu His Ala Val Gly Thr Ala Trp Ala 
            100                 105                 110         

Asp Lys Leu Lys Gly Asn Pro His Val Ser Leu Val Phe Phe Gly Asp 
        115                 120                 125             

Gly Ala Thr Ser Glu Gly Asp Phe His Glu Ala Leu Asn Phe Ala Gly 
    130                 135                 140                 

Val Tyr Gln Thr Pro Thr Ile Phe Phe Cys Gln Asn Asn Gly Tyr Ala 
145                 150                 155                 160 

Ile Ser Val Pro Phe Glu Lys Gln Ser Ala Ser Lys Thr Ile Lys Gln 
                165                 170                 175     

Arg Ser Val Ala Tyr Asp Met Arg Gly Glu Arg Val Asp Gly Asn Asp 
            180                 185                 190         

Ile Phe Ala Val Tyr Leu Thr Val Lys Arg Ala Ile Glu Gln Ala Arg 
        195                 200                 205             

Lys Gly Arg Gly Pro Thr Leu Ile Glu Ala Val Thr Thr Arg Phe Gly 
    210                 215                 220                 

Ser His Thr Thr Ala Asp Asp Ala Lys Lys Tyr Arg Asp Gln Glu Glu 
225                 230                 235                 240 

Ile Glu Arg Thr Trp Lys Glu Met Gln Asp Pro Leu Thr Arg Leu Lys 
                245                 250                 255     

Ala Tyr Ile Gln Ala Lys Gly Trp Leu Ser Glu Glu Glu Glu Ala Gln 
            260                 265                 270         

Met Lys Ala Lys Ile Arg Glu Thr Ile Asp Glu Glu Leu Ser Met Ala 
        275                 280                 285             

Glu Gln Tyr Pro Lys Pro Ser Ile Ser Gln Met Phe Glu His Val Tyr 
    290                 295                 300                 

Glu Asn Gln Pro Trp Tyr Val 
305                 310     

<210>   804
<211>   332
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   804
Val Leu Asn Glu Glu Gly Thr Val Val Gln Pro Glu Tyr Arg Glu Arg 
                5                   10                  15      

Ile Thr Lys Glu Leu Thr Met Val Met Tyr Arg His Leu Ile Arg Thr 
            20                  25                  30          

Arg Thr Phe Asp Arg Lys Cys Val Ser Leu Gln Arg Gln Gly Arg Ile 
        35                  40                  45              

Gly Thr Tyr Val Pro Tyr Glu Gly Gln Glu Ala Cys Gln Val Gly Ser 
    50                  55                  60                  

Ala Leu Ala Leu Asn Asp Glu Asp Trp Met Phe Pro Thr Tyr Arg Asp 
65                  70                  75                  80  

His Gly Ala Met Met Thr Phe Gly Arg Ser Leu Val Asn Thr Leu Leu 
                85                  90                  95      

Tyr Trp Lys Gly Arg Thr Glu Gly Cys Val Pro Pro Glu Gly Lys Lys 
            100                 105                 110         

Ile Val Pro Pro Ser Val Pro Ile Ala Thr Gln Leu Pro His Ala Ala 
        115                 120                 125             

Gly Ala Ala Cys Ala Glu Lys Trp Lys Gly Thr Lys Asn Ala Val Ile 
    130                 135                 140                 

Val Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Gly 
145                 150                 155                 160 

Leu Asn Phe Ala Ser Val Phe Asn Ala Pro Val Val Phe Phe Asn Gln 
                165                 170                 175     

Asn Asn Gln Tyr Ala Ile Ser Val Pro Ile Thr Arg Gln Met Arg Ser 
            180                 185                 190         

Lys Thr Ile Ala Gln Lys Ala Leu Ala Tyr Asp Ile Pro Gly Val Arg 
        195                 200                 205             

Ile Asp Gly Asn Asp Val Phe Ala Val Tyr Phe Gln Thr Ala Glu Ala 
    210                 215                 220                 

Leu Glu Arg Ala Arg His Gly Gly Gly Pro Thr Leu Ile Glu Ala Val 
225                 230                 235                 240 

Thr Trp Arg Tyr Gly Ala His Thr Thr Ser Asp Asp Pro Ser Arg Tyr 
                245                 250                 255     

Arg Asp Gln Glu Glu Ser Lys Lys Arg Arg Glu Thr Thr Asp Pro Ile 
            260                 265                 270         

Lys Arg Val Val Arg Leu Met Gln Arg Glu Gly Trp Trp Asn Glu Gln 
        275                 280                 285             

Trp Ala Asn Gln Val Gln Glu Glu Val Asn Ala Glu Ile Glu Gln Ala 
    290                 295                 300                 

Val Ala Glu Met Glu Arg Tyr Pro Lys Ala Asn Ala Ser Asp Met Phe 
305                 310                 315                 320 

Asp Tyr Val Phe Ala Glu Pro Thr Trp Thr Ile Ala 
                325                 330         

<210>   805
<211>   329
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   805
Met Ile Asp Glu Asn Gly Asn Glu Val Ser Gly Thr Ser Gly Phe Asp 
                5                   10                  15      

Thr Glu Leu Ala Leu Glu Phe Tyr Arg Gln Leu Val Arg Ile Arg Val 
            20                  25                  30          

Phe Asp Arg Lys Ala Val Ser Leu Gln Arg Gln Gly Arg Ile Gly Thr 
        35                  40                  45              

Tyr Ala Pro Phe Glu Gly Gln Glu Ala Ala Gln Ile Gly Ser Ala Met 
    50                  55                  60                  

Ala Leu Glu Glu Ser Asp Trp Met Phe Pro Thr Tyr Arg Asp His Gly 
65                  70                  75                  80  

Ala Ala Leu Ala Phe Gly His Ser Met Arg Asn Val Leu Leu Phe Trp 
                85                  90                  95      

Asn Gly Arg Asn Glu Gly Cys Ile Pro Pro Glu Gly Lys Asn Ile Phe 
            100                 105                 110         

Pro Pro Gly Ile Pro Ile Ala Thr Gln Ile Pro His Ala Ala Gly Ala 
        115                 120                 125             

Ala Tyr Ala Glu Lys Arg Lys Gly Thr Lys Lys Ala Ala Ile Val Tyr 
    130                 135                 140                 

Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Gly Leu Asn 
145                 150                 155                 160 

Phe Ala Ser Ile Val Lys Ala Pro Val Val Phe Phe Asn Gln Asn Asn 
                165                 170                 175     

Gln Tyr Ala Ile Ser Val Pro Leu Ser Lys Gln Met Asn Thr Lys Thr 
            180                 185                 190         

Ile Ala Gln Lys Ser Leu Ala Tyr Asp Ile Pro Gly Val Arg Val Asp 
        195                 200                 205             

Gly Asn Asp Val Phe Ala Val Tyr Arg Glu Thr Lys Lys Ala Leu Glu 
    210                 215                 220                 

Arg Ala Arg Glu Gly Gly Gly Pro Thr Leu Ile Glu Ala Val Thr Trp 
225                 230                 235                 240 

Arg Tyr Gly Ala His Thr Thr Ala Asp Asp Pro Ala Lys Tyr Arg Asp 
                245                 250                 255     

Gln Gln Glu Ser Ser Val Leu Arg Gly Lys Ile Asp Pro Ile Leu Arg 
            260                 265                 270         

Met Glu Arg Trp Leu Lys Asn Lys Asp Leu Tyr Asp Glu Asn Trp Ala 
        275                 280                 285             

Lys Arg Ala Glu Ser Glu Ala Ala Ala Glu Ile Asp Leu Ala Ile Ala 
    290                 295                 300                 

Glu Met Glu Ala Tyr Pro Pro Ala Asp Pro Ala Asp Ile Phe Asp His 
305                 310                 315                 320 

Val Phe Ala Glu Leu Ile Trp Pro Leu 
                325                 

<210>   806
<211>   350
<212>   PRT
<213>   Bacillus sp. SG-1

<400>   806
Met Ile Gln Ser Arg Asp Arg Gly Glu Glu Met Glu Glu Gln Phe Pro 
                5                   10                  15      

Ile Lys Arg Ile Ile Asp Asn Asp Gly Thr Leu Leu Gly Asp Lys Asp 
            20                  25                  30          

Pro Gly Ile Thr Glu Gln Leu Ala Lys Glu Phe Tyr Arg His Met Val 
        35                  40                  45              

Arg Ile Arg Thr Phe Asp Lys Lys Ala Ile Ser Leu Gln Arg Gln Gly 
    50                  55                  60                  

Arg Ile Gly Thr Tyr Ala Pro Phe Glu Gly Gln Glu Ala Ser Gln Val 
65                  70                  75                  80  

Gly Ser Ser Ala Ala Leu Lys Glu Asp Asp Trp Met Phe Pro Ser Tyr 
                85                  90                  95      

Arg Asp His Gly Ala Ala Met Thr Phe Gly His Ser Leu Arg Asn Ile 
            100                 105                 110         

Leu Leu Phe Trp Lys Gly Arg Asn Glu Gly Cys Val Pro Pro Gln Gly 
        115                 120                 125             

Lys Lys Ile Phe Pro Pro Gly Ile Pro Ile Ala Thr Gln Leu Pro His 
    130                 135                 140                 

Ala Ala Gly Ala Ala Tyr Ala Glu Met Arg Lys Gly Thr Lys Asn Ala 
145                 150                 155                 160 

Ala Ile Val Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His 
                165                 170                 175     

Glu Gly Leu Asn Val Ala Ser Val Leu Asn Ala Pro Val Val Phe Phe 
            180                 185                 190         

Asn Gln Asn Asn Gly Phe Ala Ile Ser Val Pro Ile Lys Lys Gln Met 
        195                 200                 205             

Lys Thr Lys Thr Ile Ala Gln Lys Ala Leu Ala Tyr Asp Ile Pro Gly 
    210                 215                 220                 

Val Arg Ile Asp Gly Asn Asp Ile Phe Ala Val Tyr Phe Glu Thr Leu 
225                 230                 235                 240 

Lys Ala Leu Glu Arg Ala Arg Asn Gly Glu Gly Pro Thr Leu Ile Glu 
                245                 250                 255     

Ala Val Thr Trp Arg Tyr Gly Ala His Thr Thr Ala Asp Asp Pro Thr 
            260                 265                 270         

Lys Tyr Arg Asp Gln Ser Glu Ser Asp Glu Arg Arg Lys Leu Gly Asp 
        275                 280                 285             

Pro Ile Ala Arg Leu Gln Arg Tyr Met Glu Arg Gln Gly Trp Trp Asp 
    290                 295                 300                 

Gln Glu Trp Ala Asp Ser Val Gln Lys Glu Tyr Thr Ala Glu Met Asp 
305                 310                 315                 320 

Gln Ala Val Glu Glu Leu Glu Ser Tyr Pro Glu Ala Asp Pro Lys Val 
                325                 330                 335     

Ile Phe Asp Tyr Val Phe Glu Lys Pro Thr Trp Thr Ile Ser 
            340                 345                 350 

<210>   807
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 800

<400>   807
Met Leu Ala Glu His Asp Arg Ala Glu Arg Leu Met Glu Ile Ala Lys 
                5                   10                  15      

Ala Glu Gly Leu Tyr Glu Glu Ile His Leu Leu Lys Glu Asp Gly Thr 
            20                  25                  30          

Leu Ala Gly Ala Val Asp Asp Ile Pro Pro Glu Val Met Val Ala Met 
        35                  40                  45              

Tyr Arg His Met Val Phe Ala Arg Ala Phe Asp Arg Lys Ala Ile Ala 
    50                  55                  60                  

Leu Gln Arg Gln Gly Arg Ile Gly Thr Tyr Ala Pro Phe Glu Gly Gln 
65                  70                  75                  80  

Glu Ala Ala Gln Val Ala Ser Ala Met Ala Leu Ala Pro Glu Asp Phe 
                85                  90                  95      

Val Phe Pro Ser Tyr Arg Asp His Ala Ala Thr Met Val Leu Gly Gln 
            100                 105                 110         

Ser Pro Ala Asn Val Leu Leu Tyr Trp Ser Gly Arg Val Glu Gly Ile 
        115                 120                 125             

Arg Ser Pro Glu Gly Arg His Ile Leu Pro Pro Ser Val Pro Ile Ala 
    130                 135                 140                 

Thr His Val Ile His Ala Val Gly Ala Ala Trp Ala Ser Arg Tyr Arg 
145                 150                 155                 160 

Lys Glu Ser Ala Val Ser Ile Ala Tyr Phe Gly Asp Gly Ala Thr Ser 
                165                 170                 175     

Glu Gly Asp Phe His Glu Ala Leu Asn Phe Ala Gly Val Phe His Leu 
            180                 185                 190         

Pro Val Leu Phe Phe Cys Gln Asn Asn Gly Tyr Ala Ile Ser Val Pro 
        195                 200                 205             

Phe Ser Arg Gln Ser Ala Ser Arg Thr Ile Ala Gln Arg Ala Ile Ala 
    210                 215                 220                 

Tyr Asp Ile Val Gly Val Arg Val Asp Gly Asn Asp Ala Phe Ala Val 
225                 230                 235                 240 

Tyr Arg Ala Val Lys Glu Ala Arg Ser Arg Ala Leu His Gly Leu Gly 
                245                 250                 255     

Pro Thr Leu Ile Glu Ala Val Thr Phe Arg Met Gly Ala His Thr Thr 
            260                 265                 270         

Ala Asp Asp Pro Thr Arg Tyr Arg Asp Gln Lys Ala Val Val Glu Ala 
        275                 280                 285             

Trp Gln Lys Arg Asp Pro Ile Val Arg Leu Arg Leu Tyr Leu Glu Ser 
    290                 295                 300                 

Gln Lys Leu Trp Ser Glu Ser Asp Glu Ala Lys Leu Gln Asp Glu Val 
305                 310                 315                 320 

Lys Ala Arg Val Glu Ala Ala Val Glu Glu Ala Leu Ser Ile Ala Pro 
                325                 330                 335     

Pro Asp Met Glu Met Met Phe Asp His Val Tyr Ala Glu Glu Pro Trp 
            340                 345                 350         

His Leu Ala Ala Glu Arg Glu Glu Tyr Arg Arg Thr Arg Glu Gly Val 
        355                 360                 365             

Ser Val 
    370 

<210>   808
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 800

<400>   808
Met Leu Ala Glu His Asp Arg Ala Glu Arg Leu Met Glu Ile Ala Lys 
                5                   10                  15      

Ala Glu Gly Leu Tyr Glu Glu Ile His Leu Leu Lys Glu Asp Gly Thr 
            20                  25                  30          

Leu Ala Gly Ala Val Asp Asp Ile Pro Pro Glu Val Met Val Ala Met 
        35                  40                  45              

Tyr Arg His Met Val Phe Ala Arg Ala Phe Asp Arg Lys Ala Ile Ala 
    50                  55                  60                  

Leu Gln Arg Gln Gly Arg Ile Gly Thr Tyr Ala Pro Phe Glu Gly Gln 
65                  70                  75                  80  

Glu Ala Ala Gln Val Ala Ser Ala Met Ala Leu Ala Pro Glu Asp Phe 
                85                  90                  95      

Val Phe Pro Ser Tyr Arg Asp His Ala Ala Thr Met Val Leu Gly Gln 
            100                 105                 110         

Ser Pro Ala Asn Val Leu Leu Tyr Trp Ser Gly Arg Val Glu Gly Ile 
        115                 120                 125             

Arg Ser Pro Glu Gly Arg His Ile Leu Pro Pro Ser Val Pro Ile Ala 
    130                 135                 140                 

Thr His Val Leu His Ala Val Gly Ala Ala Trp Ala Ser Arg Tyr Arg 
145                 150                 155                 160 

Lys Glu Ser Ala Val Ser Ile Ala Tyr Phe Gly Asp Gly Ala Thr Ser 
                165                 170                 175     

Glu Gly Asp Phe His Glu Ala Leu Asn Phe Ala Gly Val Phe His Leu 
            180                 185                 190         

Pro Val Leu Phe Phe Cys Gln Asn Asn Gly Tyr Ala Ile Ser Val Pro 
        195                 200                 205             

Phe Ser Arg Gln Ser Ala Ser Arg Thr Ile Ala Gln Arg Ala Ile Ala 
    210                 215                 220                 

Tyr Asp Ile Val Gly Val Arg Val Asp Gly Asn Asp Ala Phe Ala Val 
225                 230                 235                 240 

Tyr Arg Ala Val Lys Glu Ala Arg Ser Arg Ala Leu His Gly Leu Gly 
                245                 250                 255     

Pro Thr Leu Ile Glu Ala Val Thr Phe Arg Met Gly Ala His Thr Thr 
            260                 265                 270         

Ala Asp Asp Pro Thr Arg Tyr Arg Asp Gln Lys Ala Val Val Glu Ala 
        275                 280                 285             

Trp Gln Lys Arg Asp Pro Ile Val Arg Leu Arg Leu Tyr Leu Glu Ser 
    290                 295                 300                 

Gln Lys Leu Trp Ser Glu Ser Asp Glu Ala Lys Leu Gln Asp Glu Val 
305                 310                 315                 320 

Lys Ala Arg Val Glu Ala Ala Val Glu Glu Ala Leu Ser Ile Ala Pro 
                325                 330                 335     

Pro Asp Met Glu Met Met Phe Asp His Val Tyr Ala Glu Glu Pro Trp 
            340                 345                 350         

His Leu Ala Ala Asp Arg Glu Glu Tyr Arg Arg Thr Arg Glu Gly Val 
        355                 360                 365             

Ser Val 
    370 

<210>   809
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 800

<400>   809
Met Leu Ala Glu His Asp Arg Ala Glu Arg Leu Met Asp Ile Ala Lys 
                5                   10                  15      

Ala Glu Gly Leu Tyr Glu Glu Ile His Leu Leu Lys Glu Asp Gly Thr 
            20                  25                  30          

Leu Ala Gly Ala Val Asp Asp Ile Pro Pro Glu Val Met Val Ala Met 
        35                  40                  45              

Tyr Arg His Met Val Phe Ala Arg Ala Phe Asp Arg Lys Ala Ile Ala 
    50                  55                  60                  

Leu Gln Arg Gln Gly Arg Ile Gly Thr Tyr Ala Pro Phe Glu Gly Gln 
65                  70                  75                  80  

Glu Ala Ala Gln Val Ala Ser Ala Met Ala Leu Ala Pro Glu Asp Phe 
                85                  90                  95      

Val Phe Pro Ser Tyr Arg Asp His Ala Ala Thr Met Val Leu Gly Gln 
            100                 105                 110         

Ser Pro Ala Asn Val Leu Leu Tyr Trp Ser Gly Arg Val Glu Gly Ile 
        115                 120                 125             

Arg Ser Pro Glu Gly Arg His Ile Leu Pro Pro Ser Val Pro Ile Ala 
    130                 135                 140                 

Thr His Val Leu His Ala Val Gly Ala Ala Trp Ala Ser Arg Tyr Arg 
145                 150                 155                 160 

Lys Glu Ser Ala Val Ser Ile Ala Tyr Phe Gly Asp Gly Ala Thr Ser 
                165                 170                 175     

Glu Gly Asp Phe His Glu Ala Leu Asn Phe Ala Gly Val Phe His Leu 
            180                 185                 190         

Pro Val Leu Phe Phe Cys Gln Asn Asn Gly Tyr Ala Ile Ser Val Pro 
        195                 200                 205             

Phe Ser Arg Gln Ser Ala Ser Arg Thr Ile Ala Gln Arg Ala Ile Ala 
    210                 215                 220                 

Tyr Asp Ile Val Gly Val Arg Val Asp Gly Asn Asp Ala Phe Ala Val 
225                 230                 235                 240 

Tyr Arg Ala Val Lys Glu Ala Arg Ser Arg Ala Leu His Gly Leu Gly 
                245                 250                 255     

Pro Thr Leu Ile Glu Ala Val Thr Phe Arg Met Gly Ala His Thr Thr 
            260                 265                 270         

Ala Asp Asp Pro Thr Arg Tyr Arg Asp Gln Lys Ala Val Val Glu Ala 
        275                 280                 285             

Trp Gln Lys Arg Asp Pro Ile Val Arg Leu Arg Leu Tyr Leu Glu Ser 
    290                 295                 300                 

Gln Lys Leu Trp Ser Glu Ser Asp Glu Ala Lys Leu Gln Asp Glu Val 
305                 310                 315                 320 

Lys Ala Arg Val Glu Ala Ala Val Glu Glu Ala Leu Ser Ile Ala Pro 
                325                 330                 335     

Pro Asp Met Glu Met Met Phe Asp His Val Tyr Ala Glu Glu Pro Trp 
            340                 345                 350         

His Leu Ala Ala Glu Arg Glu Glu Tyr Arg Arg Thr Arg Glu Gly Val 
        355                 360                 365             

Ser Val 
    370 

<210>   810
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 800

<400>   810
Met Leu Ala Glu His Asp Arg Ala Glu Arg Leu Met Glu Ile Ala Lys 
                5                   10                  15      

Ala Glu Gly Leu Tyr Glu Glu Ile His Leu Leu Lys Glu Asp Gly Thr 
            20                  25                  30          

Leu Ala Gly Ala Val Asp Asp Ile Pro Pro Glu Val Met Val Ala Met 
        35                  40                  45              

Tyr Arg His Met Val Phe Ala Arg Ala Phe Asp Arg Lys Ala Ile Ala 
    50                  55                  60                  

Leu Gln Arg Gln Gly Arg Ile Gly Thr Tyr Ala Pro Phe Glu Gly Gln 
65                  70                  75                  80  

Glu Ala Ala Gln Val Ala Ser Ala Met Ala Leu Ala Pro Glu Asp Phe 
                85                  90                  95      

Val Phe Pro Ser Tyr Arg Asp His Ala Ala Thr Met Val Leu Gly Gln 
            100                 105                 110         

Ser Pro Ala Asn Val Leu Leu Tyr Trp Ser Gly Arg Val Glu Gly Ile 
        115                 120                 125             

Arg Ser Pro Glu Gly Arg His Ile Leu Pro Pro Ser Val Pro Ile Ala 
    130                 135                 140                 

Thr His Val Leu His Ala Val Gly Ala Ala Trp Ala Ser Arg Tyr Arg 
145                 150                 155                 160 

Lys Glu Ser Ala Val Ser Ile Ala Tyr Phe Gly Asp Gly Ala Thr Ser 
                165                 170                 175     

Glu Gly Asp Phe His Glu Ala Leu Asn Phe Ala Gly Val Phe His Leu 
            180                 185                 190         

Pro Val Leu Phe Phe Cys Gln Asn Asn Gly Tyr Ala Ile Ser Val Pro 
        195                 200                 205             

Phe Ser Arg Gln Ser Ala Ser Arg Thr Ile Ala Gln Arg Ala Ile Ala 
    210                 215                 220                 

Tyr Asp Ile Val Gly Val Arg Val Asp Gly Asn Asp Ala Phe Ala Val 
225                 230                 235                 240 

Tyr Arg Ala Val Lys Glu Ala Arg Ser Arg Ala Leu His Gly Leu Gly 
                245                 250                 255     

Pro Thr Leu Ile Glu Ala Val Thr Phe Arg Met Gly Ala His Thr Thr 
            260                 265                 270         

Ala Asp Asp Pro Thr Arg Tyr Arg Asp Gln Lys Ala Val Val Glu Ala 
        275                 280                 285             

Trp Gln Lys Arg Asp Pro Ile Val Arg Leu Arg Ile Tyr Leu Glu Ser 
    290                 295                 300                 

Gln Lys Leu Trp Ser Glu Ser Asp Glu Ala Lys Leu Gln Asp Glu Val 
305                 310                 315                 320 

Lys Ala Arg Val Glu Ala Ala Val Glu Glu Ala Leu Ser Ile Ala Pro 
                325                 330                 335     

Pro Asp Met Glu Met Met Phe Asp His Val Tyr Ala Glu Glu Pro Trp 
            340                 345                 350         

His Leu Ala Ala Glu Arg Glu Glu Tyr Arg Arg Thr Arg Glu Gly Val 
        355                 360                 365             

Ser Val 
    370 

<210>   811
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 800

<400>   811
Met Leu Ala Glu His Asp Arg Ala Glu Arg Leu Met Glu Ile Ala Lys 
                5                   10                  15      

Ala Glu Gly Leu Tyr Glu Glu Ile His Leu Leu Arg Glu Asp Gly Thr 
            20                  25                  30          

Leu Ala Gly Ala Val Asp Asp Ile Pro Pro Glu Val Met Val Ala Met 
        35                  40                  45              

Tyr Arg His Met Val Phe Ala Arg Ala Phe Asp Arg Lys Ala Ile Ala 
    50                  55                  60                  

Leu Gln Arg Gln Gly Arg Ile Gly Thr Tyr Ala Pro Phe Glu Gly Gln 
65                  70                  75                  80  

Glu Ala Ala Gln Val Ala Ser Ala Met Ala Leu Ala Pro Glu Asp Phe 
                85                  90                  95      

Val Phe Pro Ser Tyr Arg Asp His Ala Ala Thr Met Val Leu Gly Gln 
            100                 105                 110         

Ser Pro Ala Asn Val Leu Leu Tyr Trp Ser Gly Arg Val Glu Gly Ile 
        115                 120                 125             

Arg Ser Pro Glu Gly Arg His Ile Leu Pro Pro Ser Val Pro Ile Ala 
    130                 135                 140                 

Thr His Val Leu His Ala Val Gly Ala Ala Trp Ala Ser Arg Tyr Arg 
145                 150                 155                 160 

Lys Glu Ser Ala Val Ser Ile Ala Tyr Phe Gly Asp Gly Ala Thr Ser 
                165                 170                 175     

Glu Gly Asp Phe His Glu Ala Leu Asn Phe Ala Gly Val Phe His Leu 
            180                 185                 190         

Pro Val Leu Phe Phe Cys Gln Asn Asn Gly Tyr Ala Ile Ser Val Pro 
        195                 200                 205             

Phe Ser Arg Gln Ser Ala Ser Arg Thr Ile Ala Gln Arg Ala Ile Ala 
    210                 215                 220                 

Tyr Asp Ile Val Gly Val Arg Val Asp Gly Asn Asp Ala Phe Ala Val 
225                 230                 235                 240 

Tyr Arg Ala Val Lys Glu Ala Arg Ser Arg Ala Leu His Gly Leu Gly 
                245                 250                 255     

Pro Thr Leu Ile Glu Ala Val Thr Phe Arg Met Gly Ala His Thr Thr 
            260                 265                 270         

Ala Asp Asp Pro Thr Arg Tyr Arg Asp Gln Lys Ala Val Val Glu Ala 
        275                 280                 285             

Trp Gln Lys Arg Asp Pro Ile Val Arg Leu Arg Leu Tyr Leu Glu Ser 
    290                 295                 300                 

Gln Lys Leu Trp Ser Glu Ser Asp Glu Ala Lys Leu Gln Asp Glu Val 
305                 310                 315                 320 

Lys Ala Arg Val Glu Ala Ala Val Glu Glu Ala Leu Ser Ile Ala Pro 
                325                 330                 335     

Pro Asp Met Glu Met Met Phe Asp His Val Tyr Ala Glu Glu Pro Trp 
            340                 345                 350         

His Leu Ala Ala Glu Arg Glu Glu Tyr Arg Arg Thr Arg Glu Gly Val 
        355                 360                 365             

Ser Val 
    370 

<210>   812
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 801

<400>   812
atgttggccg aacacgatcg ggcagagcgg ctcatggaaa tcgccaaggc ggaagggctg       60

tacgaggaga ttcacctcct gaaggaggac ggcacgctgg cgggtgcggt ggacgacatc      120

ccgccggagg tcatggtggc gatgtaccgc cacatggtgt tcgcccgcgc gtttgaccgg      180

aaggccatcg cgcttcagcg gcaggggcgg attggcactt acgcgccgtt cgagggccag      240

gaggccgcgc aggtggcgag cgccatggcg ctcgcgccgg aggacttcgt gttcccgtcg      300

tatcgcgatc acgccgccac gatggtgctc gggcagtcgc ccgcgaacgt gcttctctac      360

tggtcggggc gcgtggaggg catccggagc ccggagggca ggcatatcct cccacccagc      420

gtgccgattg cgacgcacgt gattcacgcc gttggtgccg cctgggccag ccggtatcgc      480

aaggagagcg cggtcagtat cgcgtacttc ggcgacggcg cgacgagcga aggcgacttt      540

cacgaggcgc tgaatttcgc aggcgtcttc cacctgccgg tccttttctt ctgccaaaat      600

aacgggtacg ccatcagcgt gccgttctct cgccagtccg catctcgcac catcgcgcag      660

cgggcgattg cgtacgacat cgtgggcgtg cgcgtggacg gcaacgacgc gttcgcggtg      720

taccgcgccg tgaaggaggc caggtcgcgc gcgctccacg gcctcgggcc gacgctcatc      780

gaggcggtga ccttccgcat gggcgcccac accacagcgg acgatccgac gcgctaccgc      840

gatcagaagg cggtcgtgga agcgtggcag aaacgggatc cgattgtgcg cctgcgcctg      900

tacctcgagt cgcaaaagct ttggtcggaa tccgacgagg cgaagctcca ggatgaggtg      960

aaggcgcggg tggaggcggc tgtggaggag gcgctctcca tcgcgccgcc cgacatggag     1020

atgatgttcg atcacgttta cgcggaagag ccctggcacc tcgccgccga gcgcgaggag     1080

taccgcagga cccgcgaggg ggtatccgta tga                                  1113


<210>   813
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 801

<400>   813
atgttggccg aacacgatcg ggcagagcgg ctcatggaaa tcgccaaggc ggaagggctg       60

tacgaggaga ttcacctcct gaaggaggac ggcacgctgg cgggtgcggt ggacgacatc      120

ccgccggagg tcatggtggc gatgtaccgc cacatggtgt tcgcccgcgc gtttgaccgg      180

aaggccatcg cgcttcagcg gcaggggcgg attggcactt acgcgccgtt cgagggccag      240

gaggccgcgc aggtggcgag cgccatggcg ctcgcgccgg aggacttcgt gttcccgtcg      300

tatcgcgatc acgccgccac gatggtgctc gggcagtcgc ccgcgaacgt gcttctctac      360

tggtcggggc gcgtggaggg catccggagc ccggagggca ggcatatcct cccacccagc      420

gtgccgattg cgacgcacgt gttgcacgcc gttggtgccg cctgggccag ccggtatcgc      480

aaggagagcg cggtcagtat cgcgtacttc ggcgacggcg cgacgagcga aggcgacttt      540

cacgaggcgc tgaatttcgc aggcgtcttc cacctgccgg tccttttctt ctgccaaaat      600

aacgggtacg ccatcagcgt gccgttctct cgccagtccg catctcgcac catcgcgcag      660

cgggcgattg cgtacgacat cgtgggcgtg cgcgtggacg gcaacgacgc gttcgcggtg      720

taccgcgccg tgaaggaggc caggtcgcgc gcgctccacg gcctcgggcc gacgctcatc      780

gaggcggtga ccttccgcat gggcgcccac accacagcgg acgatccgac gcgctaccgc      840

gatcagaagg cggtcgtgga agcgtggcag aaacgggatc cgattgtgcg cctgcgcctg      900

tacctcgagt cgcaaaagct ttggtcggaa tccgacgagg cgaagctcca ggatgaggtg      960

aaggcgcggg tggaggcggc tgtggaggag gcgctctcca tcgcgccgcc cgacatggag     1020

atgatgttcg atcacgttta cgcggaagag ccctggcacc tcgccgccga tcgcgaggag     1080

taccgcagga cccgcgaggg ggtatccgta tga                                  1113


<210>   814
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 801

<400>   814
atgttggccg aacacgatcg ggcagagcgg ctcatggata tcgccaaggc ggaagggctg       60

tacgaggaga ttcacctcct gaaggaggac ggcacgctgg cgggtgcggt ggacgacatc      120

ccgccggagg tcatggtggc gatgtaccgc cacatggtgt tcgcccgcgc gtttgaccgg      180

aaggccatcg cgcttcagcg gcaggggcgg attggcactt acgcgccgtt cgagggccag      240

gaggccgcgc aggtggcgag cgccatggcg ctcgcgccgg aggacttcgt gttcccgtcg      300

tatcgcgatc acgccgccac gatggtgctc gggcagtcgc ccgcgaacgt gcttctctac      360

tggtcggggc gcgtggaggg catccggagc ccggagggca ggcatatcct cccacccagc      420

gtgccgattg cgacgcacgt gttgcacgcc gttggtgccg cctgggccag ccggtatcgc      480

aaggagagcg cggtcagtat cgcgtacttc ggcgacggcg cgacgagcga aggcgacttt      540

cacgaggcgc tgaatttcgc aggcgtcttc cacctgccgg tccttttctt ctgccaaaat      600

aacgggtacg ccatcagcgt gccgttctct cgccagtccg catctcgcac catcgcgcag      660

cgggcgattg cgtacgacat cgtgggcgtg cgcgtggacg gcaacgacgc gttcgcggtg      720

taccgcgccg tgaaggaggc caggtcgcgc gcgctccacg gcctcgggcc gacgctcatc      780

gaggcggtga ccttccgcat gggcgcccac accacagcgg acgatccgac gcgctaccgc      840

gatcagaagg cggtcgtgga agcgtggcag aaacgggatc cgattgtgcg cctgcgcctg      900

tacctcgagt cgcaaaagct ttggtcggaa tccgacgagg cgaagctcca ggatgaggtg      960

aaggcgcggg tggaggcggc tgtggaggag gcgctctcca tcgcgccgcc cgacatggag     1020

atgatgttcg atcacgttta cgcggaagag ccctggcacc tcgccgccga gcgcgaggag     1080

taccgcagga cccgcgaggg ggtatccgta tga                                  1113


<210>   815
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 801

<400>   815
atgttggccg aacacgatcg ggcagagcgg ctcatggaaa tcgccaaggc ggaagggctg       60

tacgaggaga ttcacctcct gaaggaggac ggcacgctgg cgggtgcggt ggacgacatc      120

ccgccggagg tcatggtggc gatgtaccgc cacatggtgt tcgcccgcgc gtttgaccgg      180

aaggccatcg cgcttcagcg gcaggggcgg attggcactt acgcgccgtt cgagggccag      240

gaggccgcgc aggtggcgag cgccatggcg ctcgcgccgg aggacttcgt gttcccgtcg      300

tatcgcgatc acgccgccac gatggtgctc gggcagtcgc ccgcgaacgt gcttctctac      360

tggtcggggc gcgtggaggg catccggagc ccggagggca ggcatatcct cccacccagc      420

gtgccgattg cgacgcacgt gttgcacgcc gttggtgccg cctgggccag ccggtatcgc      480

aaggagagcg cggtcagtat cgcgtacttc ggcgacggcg cgacgagcga aggcgacttt      540

cacgaggcgc tgaatttcgc aggcgtcttc cacctgccgg tccttttctt ctgccaaaat      600

aacgggtacg ccatcagcgt gccgttctct cgccagtccg catctcgcac catcgcgcag      660

cgggcgattg cgtacgacat cgtgggcgtg cgcgtggacg gcaacgacgc gttcgcggtg      720

taccgcgccg tgaaggaggc caggtcgcgc gcgctccacg gcctcgggcc gacgctcatc      780

gaggcggtga ccttccgcat gggcgcccac accacagcgg acgatccgac gcgctaccgc      840

gatcagaagg cggtcgtgga agcgtggcag aaacgggatc cgattgtgcg cctgcgcatt      900

tacctcgagt cgcaaaagct ttggtcggaa tccgacgagg cgaagctcca ggatgaggtg      960

aaggcgcggg tggaggcggc tgtggaggag gcgctctcca tcgcgccgcc cgacatggag     1020

atgatgttcg atcacgttta cgcggaagag ccctggcacc tcgccgccga gcgcgaggag     1080

taccgcagga cccgcgaggg ggtatccgta tga                                  1113


<210>   816
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 801

<400>   816
atgttggccg aacacgatcg ggcagagcgg ctcatggaaa tcgccaaggc ggaagggctg       60

tacgaggaga ttcacctcct gcgtgaggac ggcacgctgg cgggtgcggt ggacgacatc      120

ccgccggagg tcatggtggc gatgtaccgc cacatggtgt tcgcccgcgc gtttgaccgg      180

aaggccatcg cgcttcagcg gcaggggcgg attggcactt acgcgccgtt cgagggccag      240

gaggccgcgc aggtggcgag cgccatggcg ctcgcgccgg aggacttcgt gttcccgtcg      300

tatcgcgatc acgccgccac gatggtgctc gggcagtcgc ccgcgaacgt gcttctctac      360

tggtcggggc gcgtggaggg catccggagc ccggagggca ggcatatcct cccacccagc      420

gtgccgattg cgacgcacgt gttgcacgcc gttggtgccg cctgggccag ccggtatcgc      480

aaggagagcg cggtcagtat cgcgtacttc ggcgacggcg cgacgagcga aggcgacttt      540

cacgaggcgc tgaatttcgc aggcgtcttc cacctgccgg tccttttctt ctgccaaaat      600

aacgggtacg ccatcagcgt gccgttctct cgccagtccg catctcgcac catcgcgcag      660

cgggcgattg cgtacgacat cgtgggcgtg cgcgtggacg gcaacgacgc gttcgcggtg      720

taccgcgccg tgaaggaggc caggtcgcgc gcgctccacg gcctcgggcc gacgctcatc      780

gaggcggtga ccttccgcat gggcgcccac accacagcgg acgatccgac gcgctaccgc      840

gatcagaagg cggtcgtgga agcgtggcag aaacgggatc cgattgtgcg cctgcgcctg      900

tacctcgagt cgcaaaagct ttggtcggaa tccgacgagg cgaagctcca ggatgaggtg      960

aaggcgcggg tggaggcggc tgtggaggag gcgctctcca tcgcgccgcc cgacatggag     1020

atgatgttcg atcacgttta cgcggaagag ccctggcacc tcgccgccga gcgcgaggag     1080

taccgcagga cccgcgaggg ggtatccgta tga                                  1113


<210>   817
<211>   327
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   817
Met Ser Arg Met Leu Asn Leu Val Gln Ala Ile Asn Glu Ala Leu Asp 
                5                   10                  15      

Leu Lys Leu Ala Asp Asp Pro Arg Val Val Leu Leu Gly Glu Asp Ile 
            20                  25                  30          

Gly Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Glu Lys 
        35                  40                  45              

Tyr Gly Glu Glu Arg Val Ile Asp Thr Pro Leu Ala Glu Ser Ala Ile 
    50                  55                  60                  

Ile Gly Thr Ser Ile Gly Met Ala Val Asn Gly Leu Ile Pro Val Pro 
65                  70                  75                  80  

Glu Ile Gln Phe Leu Ala Phe Ile Phe Pro Ala Leu Asp Gln Leu Phe 
                85                  90                  95      

Ser His Val Ala Arg Met Arg Tyr Arg Ser Gln Gly Gln Phe Pro Val 
            100                 105                 110         

Pro Met Thr Ile Arg Thr Pro Tyr Gly Ala Gly Ile His Gly Pro Glu 
        115                 120                 125             

Leu His Ala Glu Ser Val Glu Ser Phe Phe Ala His Thr Pro Gly Leu 
    130                 135                 140                 

Lys Val Val Val Pro Ser Gly Pro Tyr Asp Ala Lys Gly Leu Leu Ile 
145                 150                 155                 160 

Ser Ala Ile Glu Asp Pro Asp Pro Val Val Phe Leu Glu Pro Thr Lys 
                165                 170                 175     

Leu Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Leu Tyr Arg Val 
            180                 185                 190         

Pro Ile Gly Lys Ala Lys Arg Val Arg Glu Gly Glu Asp Val Ser Val 
        195                 200                 205             

Phe Ala Trp Gly Ser Met Leu His Thr Ala Leu Lys Val Ala Glu Ala 
    210                 215                 220                 

Ile Glu Arg Glu Arg Gly Trp Thr Cys Asp Val Ile Asp Leu Arg Thr 
225                 230                 235                 240 

Leu Tyr Pro Leu Asp Arg Asp Ala Ile Val Glu Ser Val Gln Lys Thr 
                245                 250                 255     

Gly Arg Ala Val Val Val His Glu Ala His Lys Thr Ala Gly Leu Gly 
            260                 265                 270         

Ala Glu Ile Val Ser Leu Ile Asn Glu Glu Ala Leu Leu Tyr Leu Arg 
        275                 280                 285             

Ala Pro Ile Lys Arg Ile Ala Gly Phe Asp Val Pro Val Pro Phe Phe 
    290                 295                 300                 

Ala Leu Glu Asp Glu Tyr Met Pro Thr Glu Ala Arg Ile Arg Ala Gly 
305                 310                 315                 320 

Ile Glu Glu Thr Ile Thr Phe 
                325         

<210>   818
<211>   984
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   818
atgagcagga tgttgaacct ggtccaagcc atcaacgaag cgctcgatct caagctcgcg       60

gacgatccgc gcgtcgtgct cctcggcgag gacatcggga aaaacggcgg agtgtttcgc      120

gcgaccgatg gccttctcga gaagtacggc gaggagcgcg tgatcgacac gccgctcgcg      180

gagtcggcga tcatcggcac ctccatcggg atggcggtca acggcctcat cccggtgccg      240

gagattcagt ttttggcgtt catcttccct gcgctggatc agctgttctc gcacgtagct      300

cgcatgcgct accggtcgca ggggcagttt ccagtgccga tgaccatccg aacgccgtac      360

ggcgcgggca ttcacggtcc ggaactccac gccgagagcg tggagagttt cttcgcgcac      420

accccggggc tgaaggtggt cgtcccgagc ggtccgtacg acgccaaagg gctgctcatc      480

tcggccattg aagatcccga tccggtggtg ttcttggagc ccaccaagct gtaccgggcg      540

ttccgcgaag aggtgcccga agggctgtac cgggtgccca tcggcaaggc caagcgggtg      600

cgcgaaggcg aggacgtgtc ggtgttcgcg tggggctcga tgctgcacac ggcgctcaag      660

gtggcggagg ccatcgagcg cgagcggggc tggacgtgcg acgtgatcga cctccgcacg      720

ctgtatccgc tcgatcgcga cgccatcgtg gaatcggtgc agaagaccgg gcgcgcggtg      780

gtggtgcacg aggcgcacaa gacggcgggg cttggggccg agattgtgtc gctgatcaac      840

gaggaggcgc ttctctacct tcgagcgccc atcaagcgga ttgctgggtt cgatgtgccg      900

gtgccgttct tcgcactgga ggacgagtac atgccgaccg aagcgcgcat tcgcgcgggg      960

attgaagaga ccatcacgtt ctga                                             984


<210>   819
<211>   326
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   819
Ser Gln Gln Gln Thr Met Leu Gln Ala Ile Asn Gln Thr Leu Asp Asp 
                5                   10                  15      

Leu Leu Ala Thr Asn Asp Asp Val Met Leu Leu Gly Glu Asp Ile Gly 
            20                  25                  30          

Ile Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Tyr Glu Lys Tyr 
        35                  40                  45              

Gly Lys Asp Arg Val Val Asp Thr Pro Leu Ala Glu Ser Gly Ile Ile 
    50                  55                  60                  

Gly Ser Ala Ile Gly Leu Ala Met Asn Gly Lys Arg Pro Ile Val Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Ala Phe Ile Tyr Pro Gly Phe Glu Gln Leu Ile Ser 
                85                  90                  95      

His Ala Ala Arg Met Arg Tyr Arg Thr Arg Gly Gln Tyr Asn Val Pro 
            100                 105                 110         

Met Val Ile Arg Thr Pro Tyr Gly Ala Gly Ile Arg Gly Pro Glu Leu 
        115                 120                 125             

His Ser Glu Ser Val Glu Ala Phe Phe Ala His Thr Pro Gly Leu Lys 
    130                 135                 140                 

Val Val Ala Pro Ser Asn Pro Tyr Asp Ala Lys Gly Leu Leu Thr Ala 
145                 150                 155                 160 

Ala Thr Ser Asp Pro Asp Pro Val Ile Phe Leu Glu Asp Thr Lys Leu 
                165                 170                 175     

Tyr Arg Ala Phe Lys Glu Asp Val Pro Asn Thr Leu Tyr Glu Ile Pro 
            180                 185                 190         

Leu Gly Gln Ala Lys Val Val Gln Glu Gly Glu Asp Val Thr Val Ile 
        195                 200                 205             

Ala Trp Gly Gly Met Val Arg Glu Ala Leu Gln Ala Ala Lys Glu Ala 
    210                 215                 220                 

Glu Lys Ala His Gly Trp Ser Cys Glu Ile Ile Asp Leu Arg Thr Ile 
225                 230                 235                 240 

Ala Pro Ile Asp Arg Glu Thr Ile Ile Glu Ser Val Lys Lys Thr Gly 
                245                 250                 255     

Arg Ala Ile Ile Ile His Glu Ala His Lys Thr Ala Gly Leu Gly Gly 
            260                 265                 270         

Glu Ile Thr Ala Leu Ile Asn Glu Glu Ala Leu Ile Tyr Leu Lys Ala 
        275                 280                 285             

Pro Val Lys Arg Ile Ala Gly Phe Asp Ile Pro Val Pro Gln Phe Leu 
    290                 295                 300                 

Ser Glu Asn Gln Tyr Leu Pro Thr Ile Glu Arg Met Phe Arg Gly Ile 
305                 310                 315                 320 

Glu Glu Thr Val Ser Phe 
                325     

<210>   820
<211>   322
<212>   PRT
<213>   Bacillus sp. UTB2301

<400>   820
Leu Thr Leu Val Gln Ala Val Thr Asp Gly Leu Arg Thr Met Leu Lys 
                5                   10                  15      

Glu Lys Lys Glu Val Ile Val Leu Gly Glu Asp Val Gly Lys Asn Gly 
            20                  25                  30          

Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Glu Glu Phe Gly Glu Asp 
        35                  40                  45              

Arg Val Ile Asp Thr Pro Leu Ser Glu Ala Gly Ile Val Gly Val Ser 
    50                  55                  60                  

Ile Gly Met Ala Ile Asn Gly Met Leu Pro Val Ala Glu Ile Gln Phe 
65                  70                  75                  80  

Leu Gly Phe Ile Tyr Pro Ala Tyr Glu Gln Ile Met Thr His Ala Ser 
                85                  90                  95      

Arg Ile Arg Met Arg Thr Met Ser Lys Phe His Val Pro Leu Val Ile 
            100                 105                 110         

Arg Ala Pro Tyr Gly Ala Gly Val Arg Ala Pro Glu Ile His Ser Asp 
        115                 120                 125             

Ser Val Glu Thr Leu Phe Thr His Met Pro Gly Ile Lys Val Val Cys 
    130                 135                 140                 

Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ala Ala Ile Glu 
145                 150                 155                 160 

Asp Pro Asp Pro Val Leu Phe Met Glu Ser Met Lys Leu Tyr Arg Ser 
                165                 170                 175     

Ser Arg Glu Asp Val Pro Glu Gly Lys Tyr Thr Val Glu Ile Gly Lys 
            180                 185                 190         

Ala Arg Lys Val Arg Asp Gly Lys Asp Val Ser Ile Phe Ala Trp Gly 
        195                 200                 205             

Ala Met Val Pro Val Ala Thr Lys Ala Ala Glu Glu Met Glu Lys Lys 
    210                 215                 220                 

Gly Val Thr Cys Asp Val Ile Asp Leu Arg Thr Leu Tyr Pro Leu Asp 
225                 230                 235                 240 

Lys Asp Ala Ile Ala Glu Ser Val Gln Lys Thr Gly Arg Val Val Ile 
                245                 250                 255     

Val His Glu Ala His Ala Thr Gly Gly Val Ser Asn Asp Val Met Ala 
            260                 265                 270         

Val Ile Asn Asp Thr Ala Phe Leu Tyr Leu Lys Ala Pro Ile Glu Arg 
        275                 280                 285             

Val Thr Gly Phe Asp Val Pro Val Pro Phe Phe Thr Leu Glu Glu His 
    290                 295                 300                 

Tyr Leu Pro Asn Thr Gly Arg Val Val Lys Ala Ile Glu Lys Val Ile 
305                 310                 315                 320 

His Phe 
        

<210>   821
<211>   323
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   821
Thr Lys Ser Leu Thr Leu Val Gln Ala Val Asn Asp Ala Leu Arg Ile 
                5                   10                  15      

Met Leu Lys Glu Arg Asp Asp Val Val Leu Leu Gly Glu Asp Val Gly 
            20                  25                  30          

Arg Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Gln Glu Phe 
        35                  40                  45              

Gly Glu Glu Arg Val Ile Asp Thr Pro Leu Ser Glu Ala Gly Phe Thr 
    50                  55                  60                  

Gly Ala Ala Ile Gly Met Ala Leu Asn Gly Phe Arg Pro Val Val Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Ile Tyr Pro Ala Tyr Glu Gln Ile Met Thr 
                85                  90                  95      

His Ala Ala Arg Met Arg Ser Arg Thr Arg Gly His Phe Thr Val Pro 
            100                 105                 110         

Leu Val Ile Arg Ala Pro Tyr Gly Ala Gly Val Arg Ala Pro Glu Ile 
        115                 120                 125             

His Ser Asp Ser Thr Glu Ala Leu Phe Thr His Met Pro Gly Val Lys 
    130                 135                 140                 

Val Val Cys Pro Ser Ser Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ala 
145                 150                 155                 160 

Ala Ile Glu Asp Pro Asp Pro Val Leu Phe Leu Glu Pro Met Arg Asn 
                165                 170                 175     

Tyr Arg Ala Phe Arg Glu Asp Val Pro Glu Gly Lys Tyr Thr Val Asp 
            180                 185                 190         

Ile Gly Lys Gly Lys Lys Leu Arg Glu Gly Glu Asp Val Thr Val Ile 
        195                 200                 205             

Ala Trp Gly Ala Met Val Pro Val Ala Met Lys Ala Ala Glu Ala Ala 
    210                 215                 220                 

Ala Lys Lys Gly Ile Asp Ala Asp Val Ile Asp Leu Arg Thr Leu Tyr 
225                 230                 235                 240 

Pro Leu Asp Lys Asp Met Ile Ala Glu Ser Val Gln Lys Thr Gly Arg 
                245                 250                 255     

Thr Val Ile Val Gln Glu Ala His Ala Thr Gly Gly Leu Ala Asn Asp 
            260                 265                 270         

Ile Leu Ala Val Ile Asn Asp Thr Ser Phe Phe Tyr Gln Lys Ala Pro 
        275                 280                 285             

Ala Glu Arg Val Thr Gly Phe Asp Val Pro Val Pro Phe Phe Ala His 
    290                 295                 300                 

Glu Asp Asp Tyr Leu Pro Thr Pro Ala Arg Val Leu His Ala Ile Glu 
305                 310                 315                 320 

Lys Val Met 
            

<210>   822
<211>   325
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   822
Thr Lys Gln Leu Thr Leu Ile Gln Ala Ile Thr Asp Gly Met Arg Thr 
                5                   10                  15      

Met Leu His Glu Arg Glu Glu Val Val Val Leu Gly Glu Asp Val Gly 
            20                  25                  30          

Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Glu Glu Phe 
        35                  40                  45              

Gly Glu Lys Arg Val Phe Asp Thr Pro Leu Ser Glu Ala Gly Ile Ile 
    50                  55                  60                  

Gly Ser Ser Ile Gly Met Ala Ile Asn Gly Leu Leu Pro Val Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Ser Gly Phe Ile Tyr Pro Ala Tyr Glu Gln Ile Met Thr 
                85                  90                  95      

His Ala Thr Arg Met Arg Tyr Arg Thr Lys Gly Val Phe Thr Val Pro 
            100                 105                 110         

Leu Val Ile Arg Ala Pro Tyr Gly Ala Gly Val Arg Ala Pro Glu Ile 
        115                 120                 125             

His Ser Asp Ser Met Glu Ala Leu Phe Thr His Met Pro Gly Ile Lys 
    130                 135                 140                 

Val Val Cys Pro Ser Ser Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Glu Asp Pro Asp Pro Val Leu Phe Leu Glu Pro Leu Lys Leu 
                165                 170                 175     

Tyr Arg Ala Val Arg Gly Glu Val Pro Glu Glu Lys Tyr Glu Ile Glu 
            180                 185                 190         

Ile Gly Lys Gly Lys Tyr Leu Arg Glu Gly Asp Asp Val Thr Val Ile 
        195                 200                 205             

Ala Trp Gly Ala Met Val Pro Val Ala Met Lys Ala Ala Glu Gln Ala 
    210                 215                 220                 

Ala Glu Lys Gly Ile Thr Cys Glu Val Ile Asp Leu Arg Thr Leu Tyr 
225                 230                 235                 240 

Pro Ile Asp Arg Ala Ile Ile Ala Glu Ser Val Gln Lys Thr Gly Arg 
                245                 250                 255     

Cys Val Val Val His Glu Ala Pro Ala Thr Gly Gly Leu Gly Asn Asp 
            260                 265                 270         

Ile Ile Ser Ile Val Asn Asp Thr Ser Phe Leu Tyr Met Lys Ser Pro 
        275                 280                 285             

Ile Glu Arg Val Thr Gly Ala Asp Val His Val Pro Phe Trp Ala Leu 
    290                 295                 300                 

Glu Glu His Asn Ile Pro Thr Pro Ala Arg Val Met Asp Ala Ile Asn 
305                 310                 315                 320 

Gln Val Ile Asn Phe 
                325 

<210>   823
<211>   322
<212>   PRT
<213>   Exiguobacterium sibiricum 255-15

<400>   823
Met Thr Leu Val Gln Ala Val Thr Asp Ala Leu Arg Thr Lys Leu Thr 
                5                   10                  15      

Asp Asp Glu Thr Thr Leu Val Leu Gly Glu Asp Val Gly Lys Asn Gly 
            20                  25                  30          

Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Glu Glu Phe Gly Glu Asp 
        35                  40                  45              

Arg Ile Ile Asp Thr Pro Leu Ser Glu Ala Gly Ile Val Gly Thr Ser 
    50                  55                  60                  

Ile Gly Leu Ala Val Asn Gly Phe Lys Pro Ile Val Glu Ile Gln Phe 
65                  70                  75                  80  

Leu Gly Phe Ile Tyr Pro Ala Tyr Glu Gln Ile Met Thr His Val Ser 
                85                  90                  95      

Arg Ile Arg Met Arg Thr Met Gly Arg Tyr Gly Val Pro Met Val Ile 
            100                 105                 110         

Arg Ala Pro Tyr Gly Ala Gly Ile Arg Ala Pro Glu Ile His Ser Asp 
        115                 120                 125             

Ser Thr Glu Ala Leu Phe Thr Ser Met Pro Gly Leu Lys Val Val Cys 
    130                 135                 140                 

Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ala Ala Ile Glu 
145                 150                 155                 160 

Asp Pro Asp Pro Val Leu Phe Leu Glu Ser Met Arg Ser Tyr Arg Ala 
                165                 170                 175     

Phe Lys Glu Pro Val Pro Ser Glu Ala Tyr Thr Ile Glu Ile Gly Lys 
            180                 185                 190         

Ala Asn Cys Ile Thr Glu Gly Gln Asp Val Thr Leu Ile Ala Trp Gly 
        195                 200                 205             

Ala Met Val Gln Val Ala Gln Lys Ala Ala Thr Glu Ala Ala Thr Arg 
    210                 215                 220                 

Gly Ile Ser Cys Glu Val Ile Asp Leu Arg Thr Leu Tyr Pro Leu Asp 
225                 230                 235                 240 

Arg Glu Thr Ile Ser Ala Ser Val Gln Lys Thr Gly Arg Ala Val Ile 
                245                 250                 255     

Ile His Glu Ala Gln Ala Thr Gly Gly Leu Gly Asn Asp Leu Leu Ala 
            260                 265                 270         

Leu Ile Asn Asp Thr Ser Phe Leu Tyr Leu Arg Ala Pro Val Ala Arg 
        275                 280                 285             

Val Thr Gly Phe Asp Val Pro Val Pro Leu Phe Ala Leu Glu Asp His 
    290                 295                 300                 

Tyr Ile Pro Thr Pro Thr Arg Val Leu Glu Ala Ile Gln Arg Thr Val 
305                 310                 315                 320 

Asp Phe 
        

<210>   824
<211>   327
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 817

<400>   824
Met Ser Arg Met Leu Asn Leu Val Gln Ala Ile Asn Glu Ala Leu Asp 
                5                   10                  15      

Leu Lys Leu Ala Asp Asp Pro Arg Val Val Leu Leu Gly Glu Asp Ile 
            20                  25                  30          

Gly Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Glu Lys 
        35                  40                  45              

Tyr Gly Glu Glu Arg Val Ile Asp Thr Pro Leu Ala Glu Ser Ala Ile 
    50                  55                  60                  

Ile Gly Thr Ser Ile Gly Met Ala Val Asn Gly Leu Ile Pro Val Pro 
65                  70                  75                  80  

Glu Ile Gln Phe Leu Ala Phe Ile Phe Pro Ala Leu Asp Gln Leu Phe 
                85                  90                  95      

Ser His Val Ala Arg Met Arg Tyr Arg Ser Gln Gly Gln Phe Pro Val 
            100                 105                 110         

Pro Met Thr Ile Arg Thr Pro Tyr Gly Ala Gly Ile His Gly Pro Glu 
        115                 120                 125             

Leu His Ala Glu Ser Val Glu Ser Phe Phe Ala His Thr Pro Gly Leu 
    130                 135                 140                 

Lys Val Val Val Pro Ser Gly Pro Tyr Asp Ala Lys Gly Leu Leu Ile 
145                 150                 155                 160 

Ser Ala Ile Glu Asp Pro Asp Pro Val Val Phe Leu Glu Pro Thr Lys 
                165                 170                 175     

Leu Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Leu Tyr Arg Val 
            180                 185                 190         

Pro Ile Gly Lys Ala Lys Arg Val Arg Glu Gly Glu Asp Val Ser Val 
        195                 200                 205             

Phe Ala Trp Gly Ser Met Leu His Thr Ala Leu Lys Val Ala Glu Ala 
    210                 215                 220                 

Ile Glu Arg Glu Arg Gly Trp Thr Cys Asp Val Ile Asp Leu Arg Thr 
225                 230                 235                 240 

Leu Tyr Pro Leu Asp Arg Asp Ala Ile Val Glu Ser Val Gln Lys Thr 
                245                 250                 255     

Gly Arg Ala Val Val Val His Glu Ala His Lys Thr Ala Gly Leu Gly 
            260                 265                 270         

Ala Glu Ile Val Ser Leu Ile Asn Glu Glu Ala Leu Leu Tyr Leu Arg 
        275                 280                 285             

Ala Pro Ile Lys Arg Ile Ala Gly Phe Asp Val Pro Val Pro Phe Phe 
    290                 295                 300                 

Ala Leu Glu Asp Glu Tyr Met Pro Thr Asp Ala Arg Ile Arg Ala Gly 
305                 310                 315                 320 

Ile Glu Glu Thr Ile Thr Phe 
                325         

<210>   825
<211>   327
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 817

<400>   825
Met Ser Arg Met Leu Asn Leu Val Gln Ala Ile Asn Glu Ala Leu Asp 
                5                   10                  15      

Leu Lys Leu Ala Asp Asp Pro Arg Val Val Leu Leu Gly Glu Asp Ile 
            20                  25                  30          

Gly Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Glu Lys 
        35                  40                  45              

Tyr Gly Glu Glu Arg Val Ile Asp Thr Pro Leu Ala Glu Ser Ala Ile 
    50                  55                  60                  

Ile Gly Thr Ser Ile Gly Met Ala Val Asn Gly Leu Ile Pro Val Pro 
65                  70                  75                  80  

Glu Ile Gln Phe Leu Ala Phe Ile Phe Pro Ala Leu Asp Gln Leu Phe 
                85                  90                  95      

Ser His Val Ala Arg Met Arg Tyr Arg Ser Gln Gly Gln Phe Pro Val 
            100                 105                 110         

Pro Met Thr Ile Arg Thr Pro Tyr Gly Ala Gly Ile His Gly Pro Glu 
        115                 120                 125             

Leu His Ala Glu Ser Val Glu Ser Phe Phe Ala His Thr Pro Gly Leu 
    130                 135                 140                 

Lys Val Val Val Pro Ser Gly Pro Tyr Asp Ala Lys Gly Leu Leu Ile 
145                 150                 155                 160 

Ser Ala Ile Glu Asp Pro Asp Pro Val Val Phe Leu Glu Pro Thr Lys 
                165                 170                 175     

Leu Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Leu Tyr Arg Val 
            180                 185                 190         

Pro Ile Gly Lys Ala Lys Arg Val Arg Glu Gly Glu Asp Val Ser Val 
        195                 200                 205             

Phe Ala Trp Gly Ser Met Leu His Thr Ala Leu Lys Val Ala Glu Ala 
    210                 215                 220                 

Ile Glu Lys Glu Arg Gly Trp Thr Cys Asp Val Ile Asp Leu Arg Thr 
225                 230                 235                 240 

Leu Tyr Pro Leu Asp Arg Asp Ala Ile Val Glu Ser Val Gln Lys Thr 
                245                 250                 255     

Gly Arg Ala Val Val Val His Glu Ala His Lys Thr Ala Gly Leu Gly 
            260                 265                 270         

Ala Glu Ile Val Ser Leu Ile Asn Glu Glu Ala Leu Leu Tyr Leu Arg 
        275                 280                 285             

Ala Pro Ile Lys Arg Ile Ala Gly Phe Asp Val Pro Val Pro Phe Phe 
    290                 295                 300                 

Ala Leu Glu Asp Glu Tyr Met Pro Thr Glu Ala Arg Ile Arg Ala Gly 
305                 310                 315                 320 

Ile Glu Glu Thr Ile Thr Phe 
                325         

<210>   826
<211>   327
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 817

<400>   826
Met Ser Arg Met Leu Asn Leu Val Gln Ala Ile Asn Glu Ala Leu Asp 
                5                   10                  15      

Leu Lys Leu Ala Asp Asp Pro Arg Val Val Leu Leu Gly Glu Asp Ile 
            20                  25                  30          

Gly Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Glu Lys 
        35                  40                  45              

Tyr Gly Glu Glu Arg Val Ile Asp Thr Pro Leu Ala Glu Ser Ala Ile 
    50                  55                  60                  

Ile Gly Thr Ser Ile Gly Met Ala Val Asn Gly Leu Ile Pro Val Pro 
65                  70                  75                  80  

Glu Ile Gln Phe Leu Ala Phe Ile Phe Pro Ala Leu Asp Gln Leu Phe 
                85                  90                  95      

Ser His Val Ala Arg Met Arg Tyr Arg Ser Gln Gly Gln Phe Pro Val 
            100                 105                 110         

Pro Met Thr Ile Arg Thr Pro Tyr Gly Ala Gly Ile His Gly Pro Glu 
        115                 120                 125             

Leu His Ala Glu Ser Val Glu Ser Phe Phe Ala His Thr Pro Gly Leu 
    130                 135                 140                 

Lys Val Val Val Pro Ser Gly Pro Tyr Asp Ala Lys Gly Leu Leu Ile 
145                 150                 155                 160 

Ser Ala Ile Glu Asp Pro Asp Pro Val Val Phe Leu Glu Pro Thr Lys 
                165                 170                 175     

Leu Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Leu Tyr Arg Val 
            180                 185                 190         

Pro Ile Gly Lys Ala Lys Arg Val Arg Glu Gly Glu Asp Val Ser Val 
        195                 200                 205             

Phe Ala Trp Gly Ser Met Leu His Thr Ala Leu Lys Val Ala Glu Ala 
    210                 215                 220                 

Ile Glu Arg Glu Arg Gly Trp Thr Cys Asp Val Ile Asp Leu Arg Thr 
225                 230                 235                 240 

Leu Tyr Pro Leu Asp Arg Asp Ala Ile Val Glu Ser Val Gln Lys Thr 
                245                 250                 255     

Gly Arg Ala Val Val Val His Glu Ala His Lys Thr Ala Gly Leu Gly 
            260                 265                 270         

Ala Glu Ile Val Ser Leu Ile Asn Glu Glu Ala Leu Leu Tyr Ile Arg 
        275                 280                 285             

Ala Pro Ile Lys Arg Ile Ala Gly Phe Asp Val Pro Val Pro Phe Phe 
    290                 295                 300                 

Ala Leu Glu Asp Glu Tyr Met Pro Thr Glu Ala Arg Ile Arg Ala Gly 
305                 310                 315                 320 

Ile Glu Glu Thr Ile Thr Phe 
                325         

<210>   827
<211>   327
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 817

<400>   827
Met Ser Arg Met Leu Asn Leu Val Gln Ala Ile Asn Glu Ala Leu Asp 
                5                   10                  15      

Leu Lys Leu Ala Glu Asp Pro Arg Val Val Leu Leu Gly Glu Asp Ile 
            20                  25                  30          

Gly Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Glu Lys 
        35                  40                  45              

Tyr Gly Glu Glu Arg Val Ile Asp Thr Pro Leu Ala Glu Ser Ala Ile 
    50                  55                  60                  

Ile Gly Thr Ser Ile Gly Met Ala Val Asn Gly Leu Ile Pro Val Pro 
65                  70                  75                  80  

Glu Ile Gln Phe Leu Ala Phe Ile Phe Pro Ala Leu Asp Gln Leu Phe 
                85                  90                  95      

Ser His Val Ala Arg Met Arg Tyr Arg Ser Gln Gly Gln Phe Pro Val 
            100                 105                 110         

Pro Met Thr Ile Arg Thr Pro Tyr Gly Ala Gly Ile His Gly Pro Glu 
        115                 120                 125             

Leu His Ala Glu Ser Val Glu Ser Phe Phe Ala His Thr Pro Gly Leu 
    130                 135                 140                 

Lys Val Val Val Pro Ser Gly Pro Tyr Asp Ala Lys Gly Leu Leu Ile 
145                 150                 155                 160 

Ser Ala Ile Glu Asp Pro Asp Pro Val Val Phe Leu Glu Pro Thr Lys 
                165                 170                 175     

Leu Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Leu Tyr Arg Val 
            180                 185                 190         

Pro Ile Gly Lys Ala Lys Arg Val Arg Glu Gly Glu Asp Val Ser Val 
        195                 200                 205             

Phe Ala Trp Gly Ser Met Leu His Thr Ala Leu Lys Val Ala Glu Ala 
    210                 215                 220                 

Ile Glu Arg Glu Arg Gly Trp Thr Cys Asp Val Ile Asp Leu Arg Thr 
225                 230                 235                 240 

Leu Tyr Pro Leu Asp Arg Asp Ala Ile Val Glu Ser Val Gln Lys Thr 
                245                 250                 255     

Gly Arg Ala Val Val Val His Glu Ala His Lys Thr Ala Gly Leu Gly 
            260                 265                 270         

Ala Glu Ile Val Ser Leu Ile Asn Glu Glu Ala Leu Leu Tyr Leu Arg 
        275                 280                 285             

Ala Pro Ile Lys Arg Ile Ala Gly Phe Asp Val Pro Val Pro Phe Phe 
    290                 295                 300                 

Ala Leu Glu Asp Glu Tyr Met Pro Thr Glu Ala Arg Ile Arg Ala Gly 
305                 310                 315                 320 

Ile Glu Glu Thr Ile Thr Phe 
                325         

<210>   828
<211>   327
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 817

<400>   828
Met Ser Arg Met Leu Asn Leu Val Gln Ala Ile Asn Glu Ala Leu Asp 
                5                   10                  15      

Ile Lys Leu Ala Asp Asp Pro Arg Val Val Leu Leu Gly Glu Asp Ile 
            20                  25                  30          

Gly Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Glu Lys 
        35                  40                  45              

Tyr Gly Glu Glu Arg Val Ile Asp Thr Pro Leu Ala Glu Ser Ala Ile 
    50                  55                  60                  

Ile Gly Thr Ser Ile Gly Met Ala Val Asn Gly Leu Ile Pro Val Pro 
65                  70                  75                  80  

Glu Ile Gln Phe Leu Ala Phe Ile Phe Pro Ala Leu Asp Gln Leu Phe 
                85                  90                  95      

Ser His Val Ala Arg Met Arg Tyr Arg Ser Gln Gly Gln Phe Pro Val 
            100                 105                 110         

Pro Met Thr Ile Arg Thr Pro Tyr Gly Ala Gly Ile His Gly Pro Glu 
        115                 120                 125             

Leu His Ala Glu Ser Val Glu Ser Phe Phe Ala His Thr Pro Gly Leu 
    130                 135                 140                 

Lys Val Val Val Pro Ser Gly Pro Tyr Asp Ala Lys Gly Leu Leu Ile 
145                 150                 155                 160 

Ser Ala Ile Glu Asp Pro Asp Pro Val Val Phe Leu Glu Pro Thr Lys 
                165                 170                 175     

Leu Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Leu Tyr Arg Val 
            180                 185                 190         

Pro Ile Gly Lys Ala Lys Arg Val Arg Glu Gly Glu Asp Val Ser Val 
        195                 200                 205             

Phe Ala Trp Gly Ser Met Leu His Thr Ala Leu Lys Val Ala Glu Ala 
    210                 215                 220                 

Ile Glu Arg Glu Arg Gly Trp Thr Cys Asp Val Ile Asp Leu Arg Thr 
225                 230                 235                 240 

Leu Tyr Pro Leu Asp Arg Asp Ala Ile Val Glu Ser Val Gln Lys Thr 
                245                 250                 255     

Gly Arg Ala Val Val Val His Glu Ala His Lys Thr Ala Gly Leu Gly 
            260                 265                 270         

Ala Glu Ile Val Ser Leu Ile Asn Glu Glu Ala Leu Leu Tyr Leu Arg 
        275                 280                 285             

Ala Pro Ile Lys Arg Ile Ala Gly Phe Asp Val Pro Val Pro Phe Phe 
    290                 295                 300                 

Ala Leu Glu Asp Glu Tyr Met Pro Thr Glu Ala Arg Ile Arg Ala Gly 
305                 310                 315                 320 

Ile Glu Glu Thr Ile Thr Phe 
                325         

<210>   829
<211>   984
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 818

<400>   829
atgagcagga tgttgaacct ggtccaagcc atcaacgaag cgctcgatct caagctcgcg       60

gacgatccgc gcgtcgtgct cctcggcgag gacatcggga aaaacggcgg agtgtttcgc      120

gcgaccgatg gccttctcga gaagtacggc gaggagcgcg tgatcgacac gccgctcgcg      180

gagtcggcga tcatcggcac ctccatcggg atggcggtca acggcctcat cccggtgccg      240

gagattcagt ttttggcgtt catcttccct gcgctggatc agctgttctc gcacgtagct      300

cgcatgcgct accggtcgca ggggcagttt ccagtgccga tgaccatccg aacgccgtac      360

ggcgcgggca ttcacggtcc ggaactccac gccgagagcg tggagagttt cttcgcgcac      420

accccggggc tgaaggtggt cgtcccgagc ggtccgtacg acgccaaagg gctgctcatc      480

tcggccattg aagatcccga tccggtggtg ttcttggagc ccaccaagct gtaccgggcg      540

ttccgcgaag aggtgcccga agggctgtac cgggtgccca tcggcaaggc caagcgggtg      600

cgcgaaggcg aggacgtgtc ggtgttcgcg tggggctcga tgctgcacac ggcgctcaag      660

gtggcggagg ccatcgagcg cgagcggggc tggacgtgcg acgtgatcga cctccgcacg      720

ctgtatccgc tcgatcgcga cgccatcgtg gaatcggtgc agaagaccgg gcgcgcggtg      780

gtggtgcacg aggcgcacaa gacggcgggg cttggggccg agattgtgtc gctgatcaac      840

gaggaggcgc ttctctacct tcgagcgccc atcaagcgga ttgctgggtt cgatgtgccg      900

gtgccgttct tcgcactgga ggacgagtac atgccgaccg atgcgcgcat tcgcgcgggg      960

attgaagaga ccatcacgtt ctga                                             984


<210>   830
<211>   984
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 818

<400>   830
atgagcagga tgttgaacct ggtccaagcc atcaacgaag cgctcgatct caagctcgcg       60

gacgatccgc gcgtcgtgct cctcggcgag gacatcggga aaaacggcgg agtgtttcgc      120

gcgaccgatg gccttctcga gaagtacggc gaggagcgcg tgatcgacac gccgctcgcg      180

gagtcggcga tcatcggcac ctccatcggg atggcggtca acggcctcat cccggtgccg      240

gagattcagt ttttggcgtt catcttccct gcgctggatc agctgttctc gcacgtagct      300

cgcatgcgct accggtcgca ggggcagttt ccagtgccga tgaccatccg aacgccgtac      360

ggcgcgggca ttcacggtcc ggaactccac gccgagagcg tggagagttt cttcgcgcac      420

accccggggc tgaaggtggt cgtcccgagc ggtccgtacg acgccaaagg gctgctcatc      480

tcggccattg aagatcccga tccggtggtg ttcttggagc ccaccaagct gtaccgggcg      540

ttccgcgaag aggtgcccga agggctgtac cgggtgccca tcggcaaggc caagcgggtg      600

cgcgaaggcg aggacgtgtc ggtgttcgcg tggggctcga tgctgcacac ggcgctcaag      660

gtggcggagg ccatcgagaa agagcggggc tggacgtgcg acgtgatcga cctccgcacg      720

ctgtatccgc tcgatcgcga cgccatcgtg gaatcggtgc agaagaccgg gcgcgcggtg      780

gtggtgcacg aggcgcacaa gacggcgggg cttggggccg agattgtgtc gctgatcaac      840

gaggaggcgc ttctctacct tcgagcgccc atcaagcgga ttgctgggtt cgatgtgccg      900

gtgccgttct tcgcactgga ggacgagtac atgccgaccg aagcgcgcat tcgcgcgggg      960

attgaagaga ccatcacgtt ctga                                             984


<210>   831
<211>   984
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 818

<400>   831
atgagcagga tgttgaacct ggtccaagcc atcaacgaag cgctcgatct caagctcgcg       60

gacgatccgc gcgtcgtgct cctcggcgag gacatcggga aaaacggcgg agtgtttcgc      120

gcgaccgatg gccttctcga gaagtacggc gaggagcgcg tgatcgacac gccgctcgcg      180

gagtcggcga tcatcggcac ctccatcggg atggcggtca acggcctcat cccggtgccg      240

gagattcagt ttttggcgtt catcttccct gcgctggatc agctgttctc gcacgtagct      300

cgcatgcgct accggtcgca ggggcagttt ccagtgccga tgaccatccg aacgccgtac      360

ggcgcgggca ttcacggtcc ggaactccac gccgagagcg tggagagttt cttcgcgcac      420

accccggggc tgaaggtggt cgtcccgagc ggtccgtacg acgccaaagg gctgctcatc      480

tcggccattg aagatcccga tccggtggtg ttcttggagc ccaccaagct gtaccgggcg      540

ttccgcgaag aggtgcccga agggctgtac cgggtgccca tcggcaaggc caagcgggtg      600

cgcgaaggcg aggacgtgtc ggtgttcgcg tggggctcga tgctgcacac ggcgctcaag      660

gtggcggagg ccatcgagcg cgagcggggc tggacgtgcg acgtgatcga cctccgcacg      720

ctgtatccgc tcgatcgcga cgccatcgtg gaatcggtgc agaagaccgg gcgcgcggtg      780

gtggtgcacg aggcgcacaa gacggcgggg cttggggccg agattgtgtc gctgatcaac      840

gaggaggcgc ttctctacat tcgagcgccc atcaagcgga ttgctgggtt cgatgtgccg      900

gtgccgttct tcgcactgga ggacgagtac atgccgaccg aagcgcgcat tcgcgcgggg      960

attgaagaga ccatcacgtt ctga                                             984


<210>   832
<211>   984
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 818

<400>   832
atgagcagga tgttgaacct ggtccaagcc atcaacgaag cgctcgatct caagctcgcg       60

gaagatccgc gcgtcgtgct cctcggcgag gacatcggga aaaacggcgg agtgtttcgc      120

gcgaccgatg gccttctcga gaagtacggc gaggagcgcg tgatcgacac gccgctcgcg      180

gagtcggcga tcatcggcac ctccatcggg atggcggtca acggcctcat cccggtgccg      240

gagattcagt ttttggcgtt catcttccct gcgctggatc agctgttctc gcacgtagct      300

cgcatgcgct accggtcgca ggggcagttt ccagtgccga tgaccatccg aacgccgtac      360

ggcgcgggca ttcacggtcc ggaactccac gccgagagcg tggagagttt cttcgcgcac      420

accccggggc tgaaggtggt cgtcccgagc ggtccgtacg acgccaaagg gctgctcatc      480

tcggccattg aagatcccga tccggtggtg ttcttggagc ccaccaagct gtaccgggcg      540

ttccgcgaag aggtgcccga agggctgtac cgggtgccca tcggcaaggc caagcgggtg      600

cgcgaaggcg aggacgtgtc ggtgttcgcg tggggctcga tgctgcacac ggcgctcaag      660

gtggcggagg ccatcgagcg cgagcggggc tggacgtgcg acgtgatcga cctccgcacg      720

ctgtatccgc tcgatcgcga cgccatcgtg gaatcggtgc agaagaccgg gcgcgcggtg      780

gtggtgcacg aggcgcacaa gacggcgggg cttggggccg agattgtgtc gctgatcaac      840

gaggaggcgc ttctctacct tcgagcgccc atcaagcgga ttgctgggtt cgatgtgccg      900

gtgccgttct tcgcactgga ggacgagtac atgccgaccg aagcgcgcat tcgcgcgggg      960

attgaagaga ccatcacgtt ctga                                             984


<210>   833
<211>   984
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 818

<400>   833
atgagcagga tgttgaacct ggtccaagcc atcaacgaag cgctcgatat taagctcgcg       60

gacgatccgc gcgtcgtgct cctcggcgag gacatcggga aaaacggcgg agtgtttcgc      120

gcgaccgatg gccttctcga gaagtacggc gaggagcgcg tgatcgacac gccgctcgcg      180

gagtcggcga tcatcggcac ctccatcggg atggcggtca acggcctcat cccggtgccg      240

gagattcagt ttttggcgtt catcttccct gcgctggatc agctgttctc gcacgtagct      300

cgcatgcgct accggtcgca ggggcagttt ccagtgccga tgaccatccg aacgccgtac      360

ggcgcgggca ttcacggtcc ggaactccac gccgagagcg tggagagttt cttcgcgcac      420

accccggggc tgaaggtggt cgtcccgagc ggtccgtacg acgccaaagg gctgctcatc      480

tcggccattg aagatcccga tccggtggtg ttcttggagc ccaccaagct gtaccgggcg      540

ttccgcgaag aggtgcccga agggctgtac cgggtgccca tcggcaaggc caagcgggtg      600

cgcgaaggcg aggacgtgtc ggtgttcgcg tggggctcga tgctgcacac ggcgctcaag      660

gtggcggagg ccatcgagcg cgagcggggc tggacgtgcg acgtgatcga cctccgcacg      720

ctgtatccgc tcgatcgcga cgccatcgtg gaatcggtgc agaagaccgg gcgcgcggtg      780

gtggtgcacg aggcgcacaa gacggcgggg cttggggccg agattgtgtc gctgatcaac      840

gaggaggcgc ttctctacct tcgagcgccc atcaagcgga ttgctgggtt cgatgtgccg      900

gtgccgttct tcgcactgga ggacgagtac atgccgaccg aagcgcgcat tcgcgcgggg      960

attgaagaga ccatcacgtt ctga                                             984


<210>   834
<211>   343
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   834
Met Arg Ser Arg Pro Pro Lys Glu Val His Asp Met Thr Thr Phe Arg 
                5                   10                  15      

Ala His Met Val Glu Gln Asp Gly Asn Ala His Arg Ala Gly Val Arg 
            20                  25                  30          

Glu Leu Thr Leu Asp Gln Leu Pro Glu Gly Glu Val Leu Ile Arg Val 
        35                  40                  45              

Arg Tyr Ser Ser Val Asn Tyr Lys Asp Gly Ile Cys Ser Gln Pro Ala 
    50                  55                  60                  

Ser Arg Leu Val Thr Arg Tyr Pro Met Val Leu Gly Ile Asp Leu Ala 
65                  70                  75                  80  

Gly Glu Val Val Glu Ser Arg Asp Ala Arg Phe Arg Pro Gly Asp Pro 
                85                  90                  95      

Val Ile Cys Thr Ser Tyr Asp Leu Gly Thr Gly His Phe Gly Gly Phe 
            100                 105                 110         

Ser Glu Tyr Ala Arg Val Pro Ala Asp Trp Val Val Pro Leu Pro Asp 
        115                 120                 125             

Gly Leu Ser Leu Arg Asp Ala Met Val Leu Gly Thr Ala Gly Phe Thr 
    130                 135                 140                 

Ala Ala Leu Ser Leu Tyr Arg Met Glu Gln Asn Gly Val Ser Pro Ala 
145                 150                 155                 160 

Met Gly Ala Met Leu Val Thr Gly Ala Thr Gly Gly Val Gly Ala Thr 
                165                 170                 175     

Gly Ile Ala Ile Ala Lys Arg Ala Gly Tyr Arg Val Val Ala Ser Thr 
            180                 185                 190         

Arg Lys Asp Glu Ala Ala Glu Trp Leu Lys Thr Leu Gly Ala Asp Asp 
        195                 200                 205             

Val Val Arg Pro Asp Ala Leu Leu Leu Gln Glu Gly Glu Ser Tyr Leu 
    210                 215                 220                 

Asn Val Lys Thr Arg Tyr Ala Gly Val Ile Asp Pro Val Ser Gly Lys 
225                 230                 235                 240 

Tyr Val Pro His Leu Leu Gln Arg Leu Glu Tyr Gly Gly Val Ile Ala 
                245                 250                 255     

Ile Ser Gly Tyr Thr Gly Gly Pro Asp Phe Thr Ala Ser Val Phe Pro 
            260                 265                 270         

Phe Leu Arg Arg Gln Ala Ala Ile Ile Gly Ile Asp Ser Val Trp Leu 
        275                 280                 285             

Asp Met Glu Thr Arg Arg Glu Ile Trp Arg Arg Leu Ala Gly Pro Trp 
    290                 295                 300                 

Lys Pro Ser Asp Glu Ala Leu Arg Gln Ile Gly His Asp Ile Thr Leu 
305                 310                 315                 320 

Asp Asp Leu Asp Ser Ala Leu Lys Gln Ile Leu Ala Gly Arg Met Gln 
                325                 330                 335     

Gly Arg Ala Val Val Asn Leu 
            340             

<210>   835
<211>   1032
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   835
atgcgctcac gcccaccgaa ggaggtacac gacatgacca cgtttcgcgc ccacatggtg       60

gaacaggacg gaaacgcaca tcgcgccggc gtccgcgagc tcaccctaga ccaactgccc      120

gaaggtgagg tgctcatccg cgtccgctac tcgagcgtca actacaagga cggaatctgt      180

tcccagcccg cgagccggct cgtgacgcgc taccccatgg tgctcgggat tgatctcgca      240

ggcgaagtcg tcgaatcgcg ggatgctcgg tttcggccgg gcgatcccgt catctgcacc      300

agctacgatc tcggcacggg ccacttcggg ggcttcagcg aatacgcccg cgtgcctgcc      360

gactgggtgg tcccgcttcc cgacgggctg tcgctgcgcg acgccatggt gctcggcacc      420

gccggattca ccgccgcact atccctgtac cgtatggagc aaaacggcgt gtctcccgcc      480

atgggcgcca tgctcgtgac gggcgccacc ggcggcgtcg gcgcgaccgg catcgccatc      540

gccaaacggg ccgggtaccg cgtggtggcg tcgacgcgca aggacgaggc cgccgaatgg      600

ctgaaaaccc tcggcgcgga cgacgtggtg cggcccgatg cgcttcttct gcaggaaggc      660

gaatcctacc tgaacgtgaa gacgcgctat gcgggcgtga tcgatcccgt gtcgggcaaa      720

tacgtgccac acctgctgca gcgcctcgag tacggcggcg tcatcgccat cagcggttac      780

acgggcgggc cggatttcac cgccagcgtg ttcccgttcc tccgccgcca agcggccatc      840

atcggcatcg actcggtgtg gctcgacatg gagacgcgcc gcgagatctg gcgccggctc      900

gccgggccgt ggaaaccgag cgatgaggcg ctgaggcaaa tcggccacga catcacactg      960

gacgacctcg acagcgccct gaagcagatc ctcgcgggcc ggatgcaggg ccgcgccgtc     1020

gtcaacctgt ga                                                         1032


<210>   836
<211>   327
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   836
Met Pro Thr Phe Gln Ala Phe Val Val Asn Lys Thr Glu Ala Glu Phe 
                5                   10                  15      

Thr Ala Gly Val Glu Thr Leu Ser Met Asp Asp Leu Pro Glu Gly Asp 
            20                  25                  30          

Val Val Val Arg Val His Tyr Ser Ser Val Asn Tyr Lys Asp Gly Leu 
        35                  40                  45              

Ala Ser Ile Pro Asp Gly Lys Ile Val Lys Thr Tyr Pro Phe Val Pro 
    50                  55                  60                  

Gly Ile Asp Leu Ala Gly Ile Val Val Ser Ser Asn Asp Ala Arg Phe 
65                  70                  75                  80  

Arg Glu Gly Asp Glu Val Ile Ala Thr Gly Tyr Glu Ile Gly Val Thr 
                85                  90                  95      

His Phe Gly Gly Tyr Ser Glu Tyr Ala Arg Leu His Gly Asp Trp Leu 
            100                 105                 110         

Val Pro Leu Pro Lys Gly Leu Thr Leu Arg Glu Ala Met Ala Ile Gly 
        115                 120                 125             

Thr Ala Gly Phe Thr Ala Ala Leu Ser Ile His Arg Leu Glu Glu Leu 
    130                 135                 140                 

Gly Leu Val Pro Glu Arg Gly Pro Val Leu Val Thr Gly Ala Thr Gly 
145                 150                 155                 160 

Gly Val Gly Ser Leu Ala Val Ser Met Leu Ala Lys Arg Gly Tyr Thr 
                165                 170                 175     

Val Ala Ala Ser Thr Gly Lys Ala Thr Glu His Asp Tyr Leu Arg Ala 
            180                 185                 190         

Leu Gly Ala Lys Glu Val Leu Thr Arg Glu Asp Val Thr Ala Glu Arg 
        195                 200                 205             

Ile Arg Pro Leu Asp Lys Gln Arg Trp Ala Ala Ala Val Asp Pro Val 
    210                 215                 220                 

Gly Gly Arg Thr Leu Ala Thr Val Leu Ser Arg Ile Arg Tyr Gly Gly 
225                 230                 235                 240 

Ala Val Ala Val Ser Gly Leu Thr Gly Gly Val Glu Val Pro Thr Thr 
                245                 250                 255     

Val His Pro Phe Ile Leu Arg Gly Val Ser Leu Leu Gly Ile Asp Ser 
            260                 265                 270         

Val Tyr Cys Pro Met Asp Leu Arg Leu Arg Ile Trp Glu Gln Leu Ala 
        275                 280                 285             

Ser Asp Leu Lys Pro Asp Leu Glu Gln Ile Val His Glu Ile Ser Leu 
    290                 295                 300                 

His Glu Leu Pro Gly Ala Leu Ala Arg Ile Leu Arg Gly Glu Leu Arg 
305                 310                 315                 320 

Gly Arg Thr Val Val Arg Leu 
                325         

<210>   837
<211>   327
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   837
Met Ser Ala Phe Gln Ala Phe Val Val Asn Lys Thr Glu Thr Glu Phe 
                5                   10                  15      

Thr Ala Gly Val Gln Thr Ile Ser Met Asp Asp Leu Pro Glu Gly Asp 
            20                  25                  30          

Val Val Val Arg Val His Tyr Ser Ser Val Asn Tyr Lys Asp Gly Leu 
        35                  40                  45              

Ala Ser Ile Pro Asp Gly Lys Ile Val Lys Thr Tyr Pro Phe Val Pro 
    50                  55                  60                  

Gly Ile Asp Leu Ala Gly Val Val Val Ser Ser Gln His Pro Arg Phe 
65                  70                  75                  80  

Arg Glu Gly Asp Glu Val Ile Ala Thr Gly Tyr Glu Ile Gly Val Thr 
                85                  90                  95      

His Phe Gly Gly Tyr Ser Glu Tyr Ala Arg Leu His Gly Asp Trp Leu 
            100                 105                 110         

Val Pro Leu Pro Lys Gly Leu Thr Leu Lys Glu Ala Met Ala Ile Gly 
        115                 120                 125             

Thr Ala Gly Phe Thr Ala Ala Leu Ser Ile His Arg Leu Glu Glu His 
    130                 135                 140                 

Gly Leu Thr Pro Glu Arg Gly Pro Val Leu Val Thr Gly Ala Thr Gly 
145                 150                 155                 160 

Gly Val Gly Ser Leu Ala Val Ser Met Leu Ser Lys Arg Gly Tyr Thr 
                165                 170                 175     

Val Glu Ala Ser Thr Gly Lys Thr Ala Glu His Asp Tyr Leu Arg Ala 
            180                 185                 190         

Leu Gly Ala Lys Glu Val Leu Thr Arg Glu Asp Val Thr Ala Glu Arg 
        195                 200                 205             

Ile Arg Pro Leu Asp Lys Gln Arg Trp Ala Ala Ala Val Asp Pro Val 
    210                 215                 220                 

Gly Gly Arg Thr Leu Ala Thr Val Leu Ser Arg Ile Arg Tyr Gly Gly 
225                 230                 235                 240 

Ala Val Ala Val Ser Gly Leu Thr Gly Gly Ala Glu Val Pro Thr Thr 
                245                 250                 255     

Val His Pro Phe Ile Leu Arg Gly Val Ser Leu Leu Gly Ile Asp Ser 
            260                 265                 270         

Val Tyr Cys Pro Met Asp Val Arg Leu Arg Ile Trp Glu Arg Leu Ala 
        275                 280                 285             

Gly Asp Leu Lys Pro Asp Leu Glu Arg Ile Ala Gln Glu Ile Ser Leu 
    290                 295                 300                 

Ala Glu Leu Pro Gln Ala Leu Lys Arg Ile Leu Arg Gly Glu Leu Arg 
305                 310                 315                 320 

Gly Arg Met Val Val Arg Leu 
                325         

<210>   838
<211>   326
<212>   PRT
<213>   Bacillus sp. SG-1

<400>   838
Thr Phe Lys Ala Leu Val Val Asn Lys Thr Glu Glu Asp Phe Ser Val 
                5                   10                  15      

Asn Ile Glu Pro Leu Thr Phe Glu Asp Leu Pro Gln Gly Asp Val Thr 
            20                  25                  30          

Ile Arg Val His Tyr Ser Ser Val Asn Tyr Lys Asp Gly Leu Ala Ser 
        35                  40                  45              

Ile Pro Asn Gly Lys Val Val Gln Ser Tyr Pro Phe Val Pro Gly Ile 
    50                  55                  60                  

Asp Leu Ala Gly Val Val Thr Ser Ser Asp Asp Asp Arg Tyr Lys Glu 
65                  70                  75                  80  

Gly Asp Lys Val Ile Val Thr Ser Tyr Glu Leu Gly Val Ser His Tyr 
                85                  90                  95      

Gly Gly Tyr Ser Glu Tyr Ala Arg Val Pro Gly Asp Trp Val Val Pro 
            100                 105                 110         

Leu Pro Asp Asn Leu Thr Leu Lys Glu Ala Met Val Phe Gly Thr Ala 
        115                 120                 125             

Gly Phe Thr Ala Ala Leu Ser Ile His Gln Leu Glu Asn Ser Gly Leu 
    130                 135                 140                 

Arg Pro Glu Asn Gly Pro Val Leu Val Thr Gly Ala Thr Gly Gly Val 
145                 150                 155                 160 

Gly Ser Met Ala Val Ala Met Leu Ala Lys Arg Asn Tyr His Val Thr 
                165                 170                 175     

Ala Ser Thr Gly Lys Glu Ser Glu His Glu Tyr Leu Lys Ser Leu Gly 
            180                 185                 190         

Ala Lys Glu Ile Val Ser Arg Glu Glu Val Ala Pro Glu Lys Ile Arg 
        195                 200                 205             

Pro Ile Gly Lys Gln Arg Trp Ala Gly Ala Val Asp Pro Val Gly Gly 
    210                 215                 220                 

Lys Thr Leu Ala Ser Val Leu Ser Asn Thr Lys Tyr Gly Gly Ala Val 
225                 230                 235                 240 

Ala Val Ser Gly Leu Thr Gly Gly Ala Asp Val Pro Thr Thr Val Phe 
                245                 250                 255     

Pro Phe Ile Leu Arg Gly Val Asn Leu Leu Gly Ile Asp Ser Val Tyr 
            260                 265                 270         

Cys Pro Lys Glu Leu Arg Glu Thr Leu Trp Asn Arg Met Ala Asp Asp 
        275                 280                 285             

Leu Lys Pro Asp Gly Leu Gly Glu Ile Glu Asn Glu Val Thr Leu Glu 
    290                 295                 300                 

Glu Leu Pro Arg Thr Leu Ser Ala Ile Leu Gln Gly Lys Thr Arg Gly 
305                 310                 315                 320 

Arg Thr Val Val Lys Ile 
                325     

<210>   839
<211>   328
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   839
Thr Leu Phe Gln Ala Leu Gln Ala Glu Lys Asn Ala Asp Asp Val Ser 
                5                   10                  15      

Val His Val Lys Thr Ile Ser Thr Glu Asp Leu Pro Lys Asp Gly Val 
            20                  25                  30          

Leu Ile Lys Val Ala Tyr Ser Gly Ile Asn Tyr Lys Asp Gly Leu Ala 
        35                  40                  45              

Gly Lys Ala Gly Gly Asn Ile Val Arg Glu Tyr Pro Leu Ile Leu Gly 
    50                  55                  60                  

Ile Asp Ala Ala Gly Thr Val Val Ser Ser Asn Asp Pro Arg Phe Ala 
65                  70                  75                  80  

Glu Gly Asp Glu Val Ile Ala Thr Ser Tyr Glu Leu Gly Val Ser Arg 
                85                  90                  95      

Asp Gly Gly Leu Ser Glu Tyr Ala Ser Val Pro Gly Asp Trp Leu Val 
            100                 105                 110         

Pro Leu Pro Gln Asn Leu Ser Leu Lys Glu Ala Met Val Tyr Gly Thr 
        115                 120                 125             

Ala Gly Phe Thr Ala Ala Leu Ser Val His Arg Leu Glu Gln Asn Gly 
    130                 135                 140                 

Leu Ser Pro Glu Lys Gly Ser Val Leu Val Thr Gly Ala Thr Gly Gly 
145                 150                 155                 160 

Val Gly Gly Ile Ala Val Ser Met Leu Asn Lys Arg Gly Tyr Asp Val 
                165                 170                 175     

Val Ala Ser Thr Gly Asn Arg Glu Ala Ala Asp Tyr Leu Lys Gln Leu 
            180                 185                 190         

Gly Ala Ser Glu Val Ile Ser Arg Glu Asp Val Tyr Asp Gly Thr Leu 
        195                 200                 205             

Lys Ala Leu Ser Lys Gln Gln Trp Gln Gly Ala Val Asp Pro Val Gly 
    210                 215                 220                 

Gly Lys Gln Leu Ala Ser Leu Leu Ser Lys Ile Gln Tyr Gly Gly Ser 
225                 230                 235                 240 

Val Ala Val Ser Gly Leu Thr Gly Gly Gly Glu Val Pro Ala Thr Val 
                245                 250                 255     

Tyr Pro Phe Ile Leu Arg Gly Val Ser Leu Leu Gly Ile Asp Ser Val 
            260                 265                 270         

Tyr Cys Pro Met Asp Val Arg Ala Ala Val Trp Glu Arg Met Ser Ser 
        275                 280                 285             

Asp Leu Lys Pro Asp Gln Leu Leu Thr Ile Val Asp Arg Glu Val Ser 
    290                 295                 300                 

Leu Glu Glu Thr Pro Gly Ala Leu Lys Asp Ile Leu Gln Asn Arg Ile 
305                 310                 315                 320 

Gln Gly Arg Val Ile Val Lys Leu 
                325             

<210>   840
<211>   326
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   840
Phe Lys Ala Leu Val Val Asp Gln Arg Glu Asp Arg Phe Ser Val Ser 
                5                   10                  15      

Val Arg Glu Leu Ala Val Gln Asp Leu Pro Glu Gly Glu Val Leu Ile 
            20                  25                  30          

Lys Val Cys Tyr Ser Gly Val Asn Tyr Lys Asp Ser Leu Ala Ala Ile 
        35                  40                  45              

Pro Asp Gly Lys Ile Val Thr Ser Tyr Pro Phe Val Pro Gly Ile Asp 
    50                  55                  60                  

Leu Ala Gly Ile Val Val Ser Ser Asp Asp Ala Arg Phe Lys Glu Gly 
65                  70                  75                  80  

Asp Lys Val Ile Ala Thr Ser Tyr Gly Ile Gly Val Ser Arg Phe Gly 
                85                  90                  95      

Gly Tyr Ser Gly Met Ala Arg Ile Pro Ala Asp Trp Ile Val Pro Leu 
            100                 105                 110         

Pro Glu Gly Leu Thr Leu Lys Glu Ala Met Thr Ile Gly Thr Ala Gly 
        115                 120                 125             

Phe Thr Ala Ala Leu Ser Val Gln Arg Leu Glu Glu Asn His Ala Ala 
    130                 135                 140                 

Pro Glu Lys Gly Lys Val Leu Val Thr Gly Ala Thr Gly Gly Val Gly 
145                 150                 155                 160 

Ser Phe Ala Val Ser Ile Leu Ser Thr Leu Gly Tyr Glu Val Glu Ala 
                165                 170                 175     

Ser Thr Gly Lys Glu Asp Glu Ser Gly Tyr Leu Lys Ser Leu Gly Ala 
            180                 185                 190         

Lys Thr Val Ile His Arg Asp Glu Val Tyr Asn Gly Thr Leu Lys Pro 
        195                 200                 205             

Met Gln Lys Gln Lys Trp Ala Ala Ala Val Asp Pro Val Gly Gly Glu 
    210                 215                 220                 

Pro Leu Ala Ser Val Leu Ser Gln Ile Gln Tyr Gly Gly Ser Val Ala 
225                 230                 235                 240 

Val Ser Gly Leu Thr Ala Gly Thr Lys Leu Pro Ala Thr Val Phe Pro 
                245                 250                 255     

Phe Ile Leu Arg Gly Val Ser Leu Leu Gly Ile Asp Ser Val Phe Cys 
            260                 265                 270         

Pro Met Glu Thr Arg Lys Lys Thr Trp Gln Arg Leu Ala Asp Asp Phe 
        275                 280                 285             

Lys Pro Ala Asp Leu Glu Ala Phe Ile Gln Lys Glu Ile Thr Leu Glu 
    290                 295                 300                 

Glu Leu Pro Asp Thr Leu Pro Ala Leu Leu Lys Gly Glu Ala Arg Gly 
305                 310                 315                 320 

Arg Thr Ile Val Thr Ile 
                325     

<210>   841
<211>   343
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 834

<400>   841
Met Arg Ser Arg Pro Pro Lys Glu Val His Asp Met Thr Thr Phe Arg 
                5                   10                  15      

Ala His Met Val Glu Gln Asp Gly Asn Ala His Arg Ala Gly Val Arg 
            20                  25                  30          

Glu Leu Thr Leu Asp Gln Leu Pro Glu Gly Glu Val Leu Ile Arg Val 
        35                  40                  45              

Arg Tyr Ser Ser Val Asn Tyr Lys Asp Gly Ile Cys Ser Gln Pro Ala 
    50                  55                  60                  

Ser Arg Leu Val Thr Arg Tyr Pro Met Val Leu Gly Ile Asp Leu Ala 
65                  70                  75                  80  

Gly Glu Val Val Glu Ser Arg Asp Ala Arg Phe Arg Pro Gly Asp Pro 
                85                  90                  95      

Val Ile Cys Thr Ser Tyr Asp Leu Gly Thr Gly His Phe Gly Gly Phe 
            100                 105                 110         

Ser Glu Tyr Ala Arg Val Pro Ala Asp Trp Val Val Pro Leu Pro Asp 
        115                 120                 125             

Gly Leu Ser Leu Arg Asp Ala Met Val Leu Gly Thr Ala Gly Phe Thr 
    130                 135                 140                 

Ala Ala Leu Ser Leu Tyr Arg Met Glu Gln Asn Gly Val Ser Pro Ala 
145                 150                 155                 160 

Met Gly Ala Met Leu Val Thr Gly Ala Thr Gly Gly Val Gly Ala Thr 
                165                 170                 175     

Gly Ile Ala Ile Ala Lys Arg Ala Gly Tyr Arg Val Val Ala Ser Thr 
            180                 185                 190         

Arg Lys Asp Glu Ala Ala Glu Trp Leu Lys Thr Leu Gly Ala Asp Asp 
        195                 200                 205             

Val Val Arg Pro Asp Ala Leu Leu Leu Gln Glu Gly Glu Ser Tyr Leu 
    210                 215                 220                 

Asn Val Lys Thr Arg Tyr Ala Gly Val Ile Asp Pro Val Ser Gly Lys 
225                 230                 235                 240 

Tyr Val Pro His Leu Leu Gln Arg Leu Glu Tyr Gly Gly Val Ile Ala 
                245                 250                 255     

Ile Ser Gly Tyr Thr Gly Gly Pro Asp Phe Thr Ala Ser Val Phe Pro 
            260                 265                 270         

Phe Leu Arg Arg Gln Ala Ala Ile Ile Gly Ile Asp Ser Val Trp Leu 
        275                 280                 285             

Asp Met Glu Thr Arg Arg Glu Ile Trp Arg Arg Leu Ala Gly Pro Trp 
    290                 295                 300                 

Lys Pro Ser Glu Glu Ala Leu Arg Gln Ile Gly His Asp Ile Thr Leu 
305                 310                 315                 320 

Asp Asp Leu Asp Ser Ala Leu Lys Gln Ile Leu Ala Gly Arg Met Gln 
                325                 330                 335     

Gly Arg Ala Val Val Asn Leu 
            340             

<210>   842
<211>   343
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 834

<400>   842
Met Arg Ser Arg Pro Pro Lys Glu Val His Glu Met Thr Thr Phe Arg 
                5                   10                  15      

Ala His Met Val Glu Gln Asp Gly Asn Ala His Arg Ala Gly Val Arg 
            20                  25                  30          

Glu Leu Thr Leu Asp Gln Leu Pro Glu Gly Glu Val Leu Ile Arg Val 
        35                  40                  45              

Arg Tyr Ser Ser Val Asn Tyr Lys Asp Gly Ile Cys Ser Gln Pro Ala 
    50                  55                  60                  

Ser Arg Leu Val Thr Arg Tyr Pro Met Val Leu Gly Ile Asp Leu Ala 
65                  70                  75                  80  

Gly Glu Val Val Glu Ser Arg Asp Ala Arg Phe Arg Pro Gly Asp Pro 
                85                  90                  95      

Val Ile Cys Thr Ser Tyr Asp Leu Gly Thr Gly His Phe Gly Gly Phe 
            100                 105                 110         

Ser Glu Tyr Ala Arg Val Pro Ala Asp Trp Val Val Pro Leu Pro Asp 
        115                 120                 125             

Gly Leu Ser Leu Arg Asp Ala Met Val Leu Gly Thr Ala Gly Phe Thr 
    130                 135                 140                 

Ala Ala Leu Ser Leu Tyr Arg Met Glu Gln Asn Gly Val Ser Pro Ala 
145                 150                 155                 160 

Met Gly Ala Met Leu Val Thr Gly Ala Thr Gly Gly Val Gly Ala Thr 
                165                 170                 175     

Gly Ile Ala Ile Ala Lys Arg Ala Gly Tyr Arg Val Val Ala Ser Thr 
            180                 185                 190         

Arg Lys Asp Glu Ala Ala Glu Trp Leu Lys Thr Leu Gly Ala Asp Asp 
        195                 200                 205             

Val Val Arg Pro Asp Ala Leu Leu Leu Gln Glu Gly Glu Ser Tyr Leu 
    210                 215                 220                 

Asn Val Lys Thr Arg Tyr Ala Gly Val Ile Asp Pro Val Ser Gly Lys 
225                 230                 235                 240 

Tyr Val Pro His Leu Leu Gln Arg Leu Glu Tyr Gly Gly Val Ile Ala 
                245                 250                 255     

Ile Ser Gly Tyr Thr Gly Gly Pro Asp Phe Thr Ala Ser Val Phe Pro 
            260                 265                 270         

Phe Leu Arg Arg Gln Ala Ala Ile Ile Gly Ile Asp Ser Val Trp Leu 
        275                 280                 285             

Asp Met Glu Thr Arg Arg Glu Ile Trp Arg Arg Leu Ala Gly Pro Trp 
    290                 295                 300                 

Lys Pro Ser Asp Glu Ala Leu Arg Gln Ile Gly His Asp Ile Thr Leu 
305                 310                 315                 320 

Asp Asp Leu Asp Ser Ala Leu Lys Gln Ile Leu Ala Gly Arg Met Gln 
                325                 330                 335     

Gly Arg Ala Val Val Asn Leu 
            340             

<210>   843
<211>   343
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 834

<400>   843
Met Arg Ser Arg Pro Pro Lys Glu Val His Asp Met Thr Thr Phe Arg 
                5                   10                  15      

Ala His Met Val Glu Gln Asp Gly Asn Ala His Arg Ala Gly Val Arg 
            20                  25                  30          

Glu Leu Thr Ile Asp Gln Leu Pro Glu Gly Glu Val Leu Ile Arg Val 
        35                  40                  45              

Arg Tyr Ser Ser Val Asn Tyr Lys Asp Gly Ile Cys Ser Gln Pro Ala 
    50                  55                  60                  

Ser Arg Leu Val Thr Arg Tyr Pro Met Val Leu Gly Ile Asp Leu Ala 
65                  70                  75                  80  

Gly Glu Val Val Glu Ser Arg Asp Ala Arg Phe Arg Pro Gly Asp Pro 
                85                  90                  95      

Val Ile Cys Thr Ser Tyr Asp Leu Gly Thr Gly His Phe Gly Gly Phe 
            100                 105                 110         

Ser Glu Tyr Ala Arg Val Pro Ala Asp Trp Val Val Pro Leu Pro Asp 
        115                 120                 125             

Gly Leu Ser Leu Arg Asp Ala Met Val Leu Gly Thr Ala Gly Phe Thr 
    130                 135                 140                 

Ala Ala Leu Ser Leu Tyr Arg Met Glu Gln Asn Gly Val Ser Pro Ala 
145                 150                 155                 160 

Met Gly Ala Met Leu Val Thr Gly Ala Thr Gly Gly Val Gly Ala Thr 
                165                 170                 175     

Gly Ile Ala Ile Ala Lys Arg Ala Gly Tyr Arg Val Val Ala Ser Thr 
            180                 185                 190         

Arg Lys Asp Glu Ala Ala Glu Trp Leu Lys Thr Leu Gly Ala Asp Asp 
        195                 200                 205             

Val Val Arg Pro Asp Ala Leu Leu Leu Gln Glu Gly Glu Ser Tyr Leu 
    210                 215                 220                 

Asn Val Lys Thr Arg Tyr Ala Gly Val Ile Asp Pro Val Ser Gly Lys 
225                 230                 235                 240 

Tyr Val Pro His Leu Leu Gln Arg Leu Glu Tyr Gly Gly Val Ile Ala 
                245                 250                 255     

Ile Ser Gly Tyr Thr Gly Gly Pro Asp Phe Thr Ala Ser Val Phe Pro 
            260                 265                 270         

Phe Leu Arg Arg Gln Ala Ala Ile Ile Gly Ile Asp Ser Val Trp Leu 
        275                 280                 285             

Asp Met Glu Thr Arg Arg Glu Ile Trp Arg Arg Leu Ala Gly Pro Trp 
    290                 295                 300                 

Lys Pro Ser Asp Glu Ala Leu Arg Gln Ile Gly His Asp Ile Thr Leu 
305                 310                 315                 320 

Asp Asp Leu Asp Ser Ala Leu Lys Gln Ile Leu Ala Gly Arg Met Gln 
                325                 330                 335     

Gly Arg Ala Val Val Asn Leu 
            340             

<210>   844
<211>   343
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 834

<400>   844
Met Arg Ser Arg Pro Pro Lys Glu Val His Asp Met Thr Thr Phe Arg 
                5                   10                  15      

Ala His Met Val Glu Gln Asp Gly Asn Ala His Arg Ala Gly Val Arg 
            20                  25                  30          

Glu Leu Thr Leu Asp Gln Leu Pro Glu Gly Glu Val Leu Ile Arg Val 
        35                  40                  45              

Arg Tyr Ser Ser Val Asn Tyr Lys Asp Gly Ile Cys Ser Gln Pro Ala 
    50                  55                  60                  

Ser Arg Leu Val Thr Arg Tyr Pro Met Val Leu Gly Ile Asp Leu Ala 
65                  70                  75                  80  

Gly Glu Val Val Glu Ser Arg Asp Ala Arg Phe Arg Pro Gly Asp Pro 
                85                  90                  95      

Val Ile Cys Thr Ser Tyr Asp Leu Gly Thr Gly His Phe Gly Gly Phe 
            100                 105                 110         

Ser Glu Tyr Ala Arg Val Pro Ala Asp Trp Val Val Pro Leu Pro Asp 
        115                 120                 125             

Gly Leu Ser Leu Arg Asp Ala Met Val Leu Gly Thr Ala Gly Phe Thr 
    130                 135                 140                 

Ala Ala Leu Ser Leu Tyr Arg Met Glu Gln Asn Gly Val Ser Pro Ala 
145                 150                 155                 160 

Met Gly Ala Met Leu Val Thr Gly Ala Thr Gly Gly Val Gly Ala Thr 
                165                 170                 175     

Gly Ile Ala Ile Ala Lys Arg Ala Gly Tyr Arg Val Val Ala Ser Thr 
            180                 185                 190         

Arg Lys Asp Glu Ala Ala Glu Trp Leu Lys Thr Leu Gly Ala Asp Asp 
        195                 200                 205             

Val Val Arg Pro Asp Ala Leu Leu Leu Gln Glu Gly Glu Ser Tyr Leu 
    210                 215                 220                 

Asn Val Lys Thr Arg Tyr Ala Gly Val Ile Asp Pro Val Ser Gly Lys 
225                 230                 235                 240 

Tyr Val Pro His Leu Leu Gln Arg Leu Glu Tyr Gly Gly Val Ile Ala 
                245                 250                 255     

Ile Ser Gly Tyr Thr Gly Gly Pro Asp Phe Thr Ala Ser Val Phe Pro 
            260                 265                 270         

Phe Leu Arg Arg Gln Ala Ala Ile Ile Gly Ile Asp Ser Val Trp Leu 
        275                 280                 285             

Glu Met Glu Thr Arg Arg Glu Ile Trp Arg Arg Leu Ala Gly Pro Trp 
    290                 295                 300                 

Lys Pro Ser Asp Glu Ala Leu Arg Gln Ile Gly His Asp Ile Thr Leu 
305                 310                 315                 320 

Asp Asp Leu Asp Ser Ala Leu Lys Gln Ile Leu Ala Gly Arg Met Gln 
                325                 330                 335     

Gly Arg Ala Val Val Asn Leu 
            340             

<210>   845
<211>   343
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 834

<400>   845
Met Arg Ser Arg Pro Pro Lys Glu Val His Asp Met Thr Thr Phe Arg 
                5                   10                  15      

Ala His Met Val Glu Gln Asp Gly Asn Ala His Arg Ala Gly Val Arg 
            20                  25                  30          

Glu Leu Thr Leu Asp Gln Leu Pro Glu Gly Glu Val Leu Ile Arg Val 
        35                  40                  45              

Arg Tyr Ser Ser Val Asn Tyr Lys Asp Gly Ile Cys Ser Gln Pro Ala 
    50                  55                  60                  

Ser Arg Leu Val Thr Arg Tyr Pro Met Val Leu Gly Ile Asp Leu Ala 
65                  70                  75                  80  

Gly Glu Val Val Glu Ser Arg Asp Ala Arg Phe Arg Pro Gly Asp Pro 
                85                  90                  95      

Val Ile Cys Thr Ser Tyr Asp Leu Gly Thr Gly His Phe Gly Gly Phe 
            100                 105                 110         

Ser Glu Tyr Ala Arg Val Pro Ala Asp Trp Val Val Pro Leu Pro Asp 
        115                 120                 125             

Gly Leu Ser Leu Arg Asp Ala Met Val Leu Gly Thr Ala Gly Phe Thr 
    130                 135                 140                 

Ala Ala Leu Ser Leu Tyr Arg Met Glu Gln Asn Gly Val Ser Pro Ala 
145                 150                 155                 160 

Met Gly Ala Met Leu Val Thr Gly Ala Thr Gly Gly Val Gly Ala Thr 
                165                 170                 175     

Gly Ile Ala Ile Ala Lys Arg Ala Gly Tyr Arg Val Val Ala Ser Thr 
            180                 185                 190         

Arg Lys Asp Glu Ala Ala Glu Trp Leu Lys Thr Leu Gly Ala Asp Asp 
        195                 200                 205             

Val Val Arg Pro Asp Ala Leu Leu Leu Gln Glu Gly Glu Ser Tyr Leu 
    210                 215                 220                 

Asn Val Lys Thr Arg Tyr Ala Gly Val Ile Asp Pro Val Ser Gly Lys 
225                 230                 235                 240 

Tyr Val Pro His Leu Leu Gln Arg Leu Glu Tyr Gly Gly Val Ile Ala 
                245                 250                 255     

Ile Ser Gly Tyr Thr Gly Gly Pro Asp Phe Thr Ala Ser Val Phe Pro 
            260                 265                 270         

Phe Leu Arg Arg Gln Ala Ala Ile Ile Gly Ile Asp Ser Val Trp Leu 
        275                 280                 285             

Asp Met Glu Thr Arg Arg Glu Ile Trp Arg Arg Leu Ala Gly Pro Trp 
    290                 295                 300                 

Lys Pro Ser Asp Glu Ala Leu Arg Gln Ile Gly His Asp Ile Thr Leu 
305                 310                 315                 320 

Glu Asp Leu Asp Ser Ala Leu Lys Gln Ile Leu Ala Gly Arg Met Gln 
                325                 330                 335     

Gly Arg Ala Val Val Asn Leu 
            340             

<210>   846
<211>   1032
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 835

<400>   846
atgcgctcac gcccaccgaa ggaggtacac gacatgacca cgtttcgcgc ccacatggtg       60

gaacaggacg gaaacgcaca tcgcgccggc gtccgcgagc tcaccctaga ccaactgccc      120

gaaggtgagg tgctcatccg cgtccgctac tcgagcgtca actacaagga cggaatctgt      180

tcccagcccg cgagccggct cgtgacgcgc taccccatgg tgctcgggat tgatctcgca      240

ggcgaagtcg tcgaatcgcg ggatgctcgg tttcggccgg gcgatcccgt catctgcacc      300

agctacgatc tcggcacggg ccacttcggg ggcttcagcg aatacgcccg cgtgcctgcc      360

gactgggtgg tcccgcttcc cgacgggctg tcgctgcgcg acgccatggt gctcggcacc      420

gccggattca ccgccgcact atccctgtac cgtatggagc aaaacggcgt gtctcccgcc      480

atgggcgcca tgctcgtgac gggcgccacc ggcggcgtcg gcgcgaccgg catcgccatc      540

gccaaacggg ccgggtaccg cgtggtggcg tcgacgcgca aggacgaggc cgccgaatgg      600

ctgaaaaccc tcggcgcgga cgacgtggtg cggcccgatg cgcttcttct gcaggaaggc      660

gaatcctacc tgaacgtgaa gacgcgctat gcgggcgtga tcgatcccgt gtcgggcaaa      720

tacgtgccac acctgctgca gcgcctcgag tacggcggcg tcatcgccat cagcggttac      780

acgggcgggc cggatttcac cgccagcgtg ttcccgttcc tccgccgcca agcggccatc      840

atcggcatcg actcggtgtg gctcgacatg gagacgcgcc gcgagatctg gcgccggctc      900

gccgggccgt ggaaaccgag cgaagaggcg ctgaggcaaa tcggccacga catcacactg      960

gacgacctcg acagcgccct gaagcagatc ctcgcgggcc ggatgcaggg ccgcgccgtc     1020

gtcaacctgt ga                                                         1032


<210>   847
<211>   1032
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 835

<400>   847
atgcgctcac gcccaccgaa ggaggtacac gaaatgacca cgtttcgcgc ccacatggtg       60

gaacaggacg gaaacgcaca tcgcgccggc gtccgcgagc tcaccctaga ccaactgccc      120

gaaggtgagg tgctcatccg cgtccgctac tcgagcgtca actacaagga cggaatctgt      180

tcccagcccg cgagccggct cgtgacgcgc taccccatgg tgctcgggat tgatctcgca      240

ggcgaagtcg tcgaatcgcg ggatgctcgg tttcggccgg gcgatcccgt catctgcacc      300

agctacgatc tcggcacggg ccacttcggg ggcttcagcg aatacgcccg cgtgcctgcc      360

gactgggtgg tcccgcttcc cgacgggctg tcgctgcgcg acgccatggt gctcggcacc      420

gccggattca ccgccgcact atccctgtac cgtatggagc aaaacggcgt gtctcccgcc      480

atgggcgcca tgctcgtgac gggcgccacc ggcggcgtcg gcgcgaccgg catcgccatc      540

gccaaacggg ccgggtaccg cgtggtggcg tcgacgcgca aggacgaggc cgccgaatgg      600

ctgaaaaccc tcggcgcgga cgacgtggtg cggcccgatg cgcttcttct gcaggaaggc      660

gaatcctacc tgaacgtgaa gacgcgctat gcgggcgtga tcgatcccgt gtcgggcaaa      720

tacgtgccac acctgctgca gcgcctcgag tacggcggcg tcatcgccat cagcggttac      780

acgggcgggc cggatttcac cgccagcgtg ttcccgttcc tccgccgcca agcggccatc      840

atcggcatcg actcggtgtg gctcgacatg gagacgcgcc gcgagatctg gcgccggctc      900

gccgggccgt ggaaaccgag cgatgaggcg ctgaggcaaa tcggccacga catcacactg      960

gacgacctcg acagcgccct gaagcagatc ctcgcgggcc ggatgcaggg ccgcgccgtc     1020

gtcaacctgt ga                                                         1032


<210>   848
<211>   1032
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 835

<400>   848
atgcgctcac gcccaccgaa ggaggtacac gacatgacca cgtttcgcgc ccacatggtg       60

gaacaggacg gaaacgcaca tcgcgccggc gtccgcgagc tcaccattga ccaactgccc      120

gaaggtgagg tgctcatccg cgtccgctac tcgagcgtca actacaagga cggaatctgt      180

tcccagcccg cgagccggct cgtgacgcgc taccccatgg tgctcgggat tgatctcgca      240

ggcgaagtcg tcgaatcgcg ggatgctcgg tttcggccgg gcgatcccgt catctgcacc      300

agctacgatc tcggcacggg ccacttcggg ggcttcagcg aatacgcccg cgtgcctgcc      360

gactgggtgg tcccgcttcc cgacgggctg tcgctgcgcg acgccatggt gctcggcacc      420

gccggattca ccgccgcact atccctgtac cgtatggagc aaaacggcgt gtctcccgcc      480

atgggcgcca tgctcgtgac gggcgccacc ggcggcgtcg gcgcgaccgg catcgccatc      540

gccaaacggg ccgggtaccg cgtggtggcg tcgacgcgca aggacgaggc cgccgaatgg      600

ctgaaaaccc tcggcgcgga cgacgtggtg cggcccgatg cgcttcttct gcaggaaggc      660

gaatcctacc tgaacgtgaa gacgcgctat gcgggcgtga tcgatcccgt gtcgggcaaa      720

tacgtgccac acctgctgca gcgcctcgag tacggcggcg tcatcgccat cagcggttac      780

acgggcgggc cggatttcac cgccagcgtg ttcccgttcc tccgccgcca agcggccatc      840

atcggcatcg actcggtgtg gctcgacatg gagacgcgcc gcgagatctg gcgccggctc      900

gccgggccgt ggaaaccgag cgatgaggcg ctgaggcaaa tcggccacga catcacactg      960

gacgacctcg acagcgccct gaagcagatc ctcgcgggcc ggatgcaggg ccgcgccgtc     1020

gtcaacctgt ga                                                         1032


<210>   849
<211>   1032
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 835

<400>   849
atgcgctcac gcccaccgaa ggaggtacac gacatgacca cgtttcgcgc ccacatggtg       60

gaacaggacg gaaacgcaca tcgcgccggc gtccgcgagc tcaccctaga ccaactgccc      120

gaaggtgagg tgctcatccg cgtccgctac tcgagcgtca actacaagga cggaatctgt      180

tcccagcccg cgagccggct cgtgacgcgc taccccatgg tgctcgggat tgatctcgca      240

ggcgaagtcg tcgaatcgcg ggatgctcgg tttcggccgg gcgatcccgt catctgcacc      300

agctacgatc tcggcacggg ccacttcggg ggcttcagcg aatacgcccg cgtgcctgcc      360

gactgggtgg tcccgcttcc cgacgggctg tcgctgcgcg acgccatggt gctcggcacc      420

gccggattca ccgccgcact atccctgtac cgtatggagc aaaacggcgt gtctcccgcc      480

atgggcgcca tgctcgtgac gggcgccacc ggcggcgtcg gcgcgaccgg catcgccatc      540

gccaaacggg ccgggtaccg cgtggtggcg tcgacgcgca aggacgaggc cgccgaatgg      600

ctgaaaaccc tcggcgcgga cgacgtggtg cggcccgatg cgcttcttct gcaggaaggc      660

gaatcctacc tgaacgtgaa gacgcgctat gcgggcgtga tcgatcccgt gtcgggcaaa      720

tacgtgccac acctgctgca gcgcctcgag tacggcggcg tcatcgccat cagcggttac      780

acgggcgggc cggatttcac cgccagcgtg ttcccgttcc tccgccgcca agcggccatc      840

atcggcatcg actcggtgtg gctcgaaatg gagacgcgcc gcgagatctg gcgccggctc      900

gccgggccgt ggaaaccgag cgatgaggcg ctgaggcaaa tcggccacga catcacactg      960

gacgacctcg acagcgccct gaagcagatc ctcgcgggcc ggatgcaggg ccgcgccgtc     1020

gtcaacctgt ga                                                         1032


<210>   850
<211>   1032
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 835

<400>   850
atgcgctcac gcccaccgaa ggaggtacac gacatgacca cgtttcgcgc ccacatggtg       60

gaacaggacg gaaacgcaca tcgcgccggc gtccgcgagc tcaccctaga ccaactgccc      120

gaaggtgagg tgctcatccg cgtccgctac tcgagcgtca actacaagga cggaatctgt      180

tcccagcccg cgagccggct cgtgacgcgc taccccatgg tgctcgggat tgatctcgca      240

ggcgaagtcg tcgaatcgcg ggatgctcgg tttcggccgg gcgatcccgt catctgcacc      300

agctacgatc tcggcacggg ccacttcggg ggcttcagcg aatacgcccg cgtgcctgcc      360

gactgggtgg tcccgcttcc cgacgggctg tcgctgcgcg acgccatggt gctcggcacc      420

gccggattca ccgccgcact atccctgtac cgtatggagc aaaacggcgt gtctcccgcc      480

atgggcgcca tgctcgtgac gggcgccacc ggcggcgtcg gcgcgaccgg catcgccatc      540

gccaaacggg ccgggtaccg cgtggtggcg tcgacgcgca aggacgaggc cgccgaatgg      600

ctgaaaaccc tcggcgcgga cgacgtggtg cggcccgatg cgcttcttct gcaggaaggc      660

gaatcctacc tgaacgtgaa gacgcgctat gcgggcgtga tcgatcccgt gtcgggcaaa      720

tacgtgccac acctgctgca gcgcctcgag tacggcggcg tcatcgccat cagcggttac      780

acgggcgggc cggatttcac cgccagcgtg ttcccgttcc tccgccgcca agcggccatc      840

atcggcatcg actcggtgtg gctcgacatg gagacgcgcc gcgagatctg gcgccggctc      900

gccgggccgt ggaaaccgag cgatgaggcg ctgaggcaaa tcggccacga catcacactg      960

gaagacctcg acagcgccct gaagcagatc ctcgcgggcc ggatgcaggg ccgcgccgtc     1020

gtcaacctgt ga                                                         1032


<210>   851
<211>   994
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   851
Met Ile Asp Ile Arg Thr Glu Ala Gln Ala Glu Ala Arg Thr Val Gln 
                5                   10                  15      

Leu Glu Ile Asp Gly Lys Glu Val Thr Val Glu Arg Gly Ala Ser Val 
            20                  25                  30          

Leu Asp Ala Ile Leu Ser Thr Gly Gln Glu His Pro His Val Cys Tyr 
        35                  40                  45              

His Pro Ala Leu Gly Pro Ile Glu Thr Cys Asp Thr Cys Ile Val Glu 
    50                  55                  60                  

Ile Asp Gly Lys Leu Met Arg Ala Cys Ser Thr Pro Val Glu Asp Gly 
65                  70                  75                  80  

Met Ala Val Arg Thr Lys Ser Val Ala Ala Arg Tyr Ala Arg Lys Glu 
                85                  90                  95      

Ala Met Asp Arg Ile Leu Lys Asn His Glu Leu Tyr Cys Thr Val Cys 
            100                 105                 110         

Asp Asn Asn Asn Gly Asn Cys Val Leu His Asn Thr Val Met Gln Met 
        115                 120                 125             

Gly Val Glu His Gln Ala Tyr Pro Phe Thr Pro Lys Pro Tyr Glu Val 
    130                 135                 140                 

Asp Met Ser Asn Pro Phe Tyr Arg Tyr Asp Pro Gln Gln Cys Ile Leu 
145                 150                 155                 160 

Cys Gly Arg Cys Val Glu Ala Cys Gln Asn Leu Gln Val Ser Glu Val 
                165                 170                 175     

Leu Ser Ile Ala Trp Asp Arg Glu Val Pro Arg Val Ile Trp Asp Asn 
            180                 185                 190         

Asp Val Pro Ile Asn Glu Ser Ser Cys Val Ser Cys Gly His Cys Val 
        195                 200                 205             

Thr Val Cys Pro Thr Asn Ala Leu Met Glu Lys Ser Met Leu Gly Glu 
    210                 215                 220                 

Ala Gly Phe Leu Thr Gly Ile Glu Lys Pro Thr Leu Asp Lys Met Ile 
225                 230                 235                 240 

Asp Ile Thr Lys Lys Val Glu Pro Gly Tyr Ser Ser Ile Phe Val Val 
                245                 250                 255     

Ser Glu Ile Glu His Glu Met Arg Glu Ala Arg Ile Arg Lys Thr Lys 
            260                 265                 270         

Thr Val Cys Thr Tyr Cys Gly Val Gly Cys Ala Phe Asp Val Trp Thr 
        275                 280                 285             

Lys Asp Arg His Ile Leu Lys Val Glu Pro Gln Met Glu Ala Pro Val 
    290                 295                 300                 

Asn Gln Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp Asp Phe Val 
305                 310                 315                 320 

Asn Ser Pro Asp Arg Leu Thr Lys Pro Leu Val Arg Lys Gly Asp Arg 
                325                 330                 335     

Phe Val Glu Val Ser Trp Asp Glu Ala Leu Asp Val Ile Glu Arg Arg 
            340                 345                 350         

Ile Lys Glu Ile Gln Ala Lys His Gly Tyr Asp Ala Val Ala Phe Ile 
        355                 360                 365             

Ser Ser Ser Lys Thr Thr Asn Glu Glu Asn Tyr Leu Met Gln Lys Leu 
    370                 375                 380                 

Ala Arg Ala Val Met His Thr Asn Asn Ile Asp Asn Cys Ser Arg Tyr 
385                 390                 395                 400 

Cys Gln Ser Pro Ala Thr Glu Ala Leu Arg Arg Thr Met Gly Leu Gly 
                405                 410                 415     

Gly Asp Thr Gly Ser Ile Lys Asp Leu Glu Leu Ala Asp Leu Val Leu 
            420                 425                 430         

Ile Val Gly Ala Asn Pro Ala Glu Ala His Pro Val Leu Ser Thr Arg 
        435                 440                 445             

Leu Arg Arg Ala Gln Lys Lys Arg Gly Gln Lys His Ile Val Ala Asp 
    450                 455                 460                 

Val Arg Arg Asn Ile Met Ala Thr Arg Ala Asp Leu Phe Ile Gln Pro 
465                 470                 475                 480 

Arg Gln Gly Thr Asp Leu Val Trp Leu Ser Ala Val Thr Lys Tyr Ile 
                485                 490                 495     

Ile Asp Gln Gly Arg His Asp Glu Ala Phe Leu Arg Asp Arg Val Asn 
            500                 505                 510         

Gly Phe Asp Glu Tyr Val Gln Ser Leu Glu Lys Phe Thr Leu Asp Tyr 
        515                 520                 525             

Ala Ser Glu Ile Cys Gly Leu Arg Lys Glu Glu Leu Val Arg Val Ala 
    530                 535                 540                 

Glu Met Ile Met Glu Ala Lys Arg Val Ala Val Cys Trp Ala Met Gly 
545                 550                 555                 560 

Val Thr Gln His Arg Gly Gly Ser Asp Thr Ser Thr Ala Ile Cys Asn 
                565                 570                 575     

Leu Leu Leu Val Thr Gly Asn Val Ala Arg Pro Gly Thr Gly Ala Tyr 
            580                 585                 590         

Pro Leu Arg Gly His Asn Asn Val Gln Gly Ala Gly Asp Met Gly Cys 
        595                 600                 605             

Ala Pro Pro Phe Leu Pro Gly Tyr Glu Arg Val Asp Asn Glu Glu Gln 
    610                 615                 620                 

Arg Arg Lys Trp Glu Lys Leu Trp Gly Val Glu Leu Pro Thr Thr Pro 
625                 630                 635                 640 

Gly Leu Asn Asn His Gln Met Val Asp Ala Ile His Glu Gly Lys Leu 
                645                 650                 655     

Lys Ala Met Tyr Leu Cys Gly Glu Asp Met Ala Val Val Asp Ser Asn 
            660                 665                 670         

Ala Asn Tyr Val Glu Asp Ala Phe Arg Lys Leu Glu Phe Phe Val Val 
        675                 680                 685             

Gln Asp Val Phe Leu Ser Lys Thr Ala Gln Phe Ala Asp Val Val Leu 
    690                 695                 700                 

Pro Ala Cys Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr Asn Thr Glu 
705                 710                 715                 720 

Arg Arg Ile Gln Arg Leu Tyr Arg Val Leu Glu Pro Leu Gly Asp Ala 
                725                 730                 735     

Lys Pro Asp Trp Glu Ile Ile Gln Met Val Ala Asn Arg Phe Gly Ala 
            740                 745                 750         

His Trp Asn Tyr Thr Ser Ala Arg Glu Ile Phe Glu Glu Met Ala Ser 
        755                 760                 765             

Ala Ala Asp Leu Phe Arg Gly Ala Ser Tyr Asp Arg Leu Glu Gly Tyr 
    770                 775                 780                 

Gly Ser Leu Gln Trp Pro Val Leu Pro Asp Gly Thr Asp Thr Pro Leu 
785                 790                 795                 800 

Leu Tyr Thr Asp Gly Phe Ala Phe Pro Asp Lys Lys Ala Arg Leu Tyr 
                805                 810                 815     

Pro Val Asp Trp Thr Pro Pro Ile Glu Val Gly Glu Glu Tyr Asp Leu 
            820                 825                 830         

Glu Leu Asn Asn Gly Arg Leu Leu Glu His Phe His Glu Gly Asn Met 
        835                 840                 845             

Thr Ser Arg Val Pro Gly Ile His Glu Lys Val Pro Glu Thr Phe Val 
    850                 855                 860                 

Glu Ile Ser Pro Glu Leu Ala Lys Glu Arg Gly Val Gln Asp Gly Ala 
865                 870                 875                 880 

Leu Val Arg Leu Val Ser Pro Tyr Gly Ser Ile Lys Val Arg Val Ala 
                885                 890                 895     

Val Thr Asp Arg Val Ser Gly Lys His Val Tyr Val Pro Leu Leu Ser 
            900                 905                 910         

His Ala Asp Glu Glu Ala Val Asn Arg Leu Thr Ser Ser Asp His Asp 
        915                 920                 925             

Thr Ala Thr Tyr Thr Pro Ala Tyr Lys Glu Met Arg Val Arg Met Glu 
    930                 935                 940                 

Val Ile Gln Ser Cys Gly Glu Pro Pro Ile Lys Arg Gly Asn Phe Arg 
945                 950                 955                 960 

Leu Gly Lys Pro Asn Pro Gln Pro Gly Val Asn Val Glu Gln Lys Trp 
                965                 970                 975     

Ala Arg Lys Asp Tyr Val Pro Leu Val Thr Asp Arg Ala Leu Val Lys 
            980                 985                 990         

Glu Gly 
        

<210>   852
<211>   2985
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   852
atgatcgata tcaggaccga agcacaggcc gaggcgcgga ccgtgcaact cgagatcgac       60

ggcaaggaag tcaccgtgga acgaggtgcg tcggtgctcg acgccattct gtccacgggc      120

caggaacatc cgcacgtctg ttatcatccg gcgctcggcc ccattgaaac gtgcgacacc      180

tgcattgtcg agatcgacgg caagctgatg cgcgcgtgtt ccacacctgt cgaggacggg      240

atggcggtcc ggaccaagtc cgtggccgcg cggtatgccc gcaaagaggc gatggaccgc      300

attctgaaga accacgagct gtactgcacc gtgtgcgaca acaacaacgg caactgcgtg      360

ctgcacaaca ccgtgatgca gatgggcgtg gaacatcagg cgtatccgtt cacgcccaag      420

ccgtacgagg tcgacatgtc gaacccgttt tatcggtacg atccgcagca gtgcatcctt      480

tgcggccgct gcgtcgaggc gtgccaaaac ctgcaggtga gcgaggttct ctccatcgcg      540

tgggatcgcg aggtgccgcg ggtcatctgg gacaacgacg tgcccatcaa cgagtcgtcg      600

tgtgtgtcgt gtggccactg cgtgacggtc tgtccgacca acgcgctcat ggaaaaatcc      660

atgcttgggg aagcgggctt cctcacgggc atcgaaaagc cgaccctgga taagatgatc      720

gacatcacca agaaggtcga gcccggttac tcgtccatct ttgtcgtctc ggagattgag      780

cacgagatgc gcgaagcgcg cattcggaag acgaagacgg tctgcacgta ttgcggcgtg      840

ggctgcgcgt tcgacgtgtg gacgaaggat cggcacattt taaaggtcga gccgcagatg      900

gaggcgccgg tcaaccagat ctccacgtgc gtcaagggca agttcggctg ggactttgtg      960

aacagcccgg atcgcctgac caagcctctg gtgcgcaagg gcgatcggtt cgtggaagtg     1020

agctgggacg aggcgctcga cgtgatcgaa cggcgcatca aggagatcca ggcgaagcac     1080

gggtacgacg cggtggcgtt catctcgtcg tccaagacga ccaacgaaga aaactacctg     1140

atgcagaagc tggcgcgcgc cgtcatgcac acgaacaaca tcgacaactg ctcgcgttac     1200

tgccagtctc ctgcgaccga ggcgctgcgg cggaccatgg ggctcggcgg cgacaccgga     1260

tctatcaagg atctggagct ggccgatctc gtcctcatcg tcggcgcgaa ccctgccgag     1320

gcgcatcccg tgttgtcgac gcgcctgcgc cgggcgcaga agaagcgcgg ccagaagcac     1380

atcgtggccg acgtgcggcg caacatcatg gcgacacgcg ccgatctctt catccagccg     1440

cgccagggca cggacttggt ctggttgtcc gcggtgacga agtacatcat cgatcagggc     1500

cggcacgacg aggcattcct gcgggatcgc gtgaatggct ttgacgaata cgtgcagtcg     1560

ctcgagaagt tcacgctgga ctacgcgagc gagatctgcg gcctccgcaa agaggagctc     1620

gtccgcgtgg ccgagatgat catggaggca aagcgcgtcg cggtctgctg ggccatgggc     1680

gtgacgcagc accggggtgg cagtgacacg tcgaccgcca tctgcaactt gcttttggtg     1740

accgggaacg tggcgcggcc gggcacgggt gcgtatccgc tgcgcggtca caacaacgtg     1800

cagggagccg gtgacatggg ctgcgcgcct ccgttcctgc cgggctacga gcgcgtggac     1860

aacgaagagc agcggcgcaa gtgggagaag ctctggggcg tcgaactgcc gaccacgcct     1920

gggctcaaca atcatcagat ggtggatgcc attcacgaag gcaagctgaa ggcgatgtac     1980

ctctgcgggg aggacatggc ggtggtggac tccaacgcca actacgtgga ggacgccttc     2040

cggaaactcg agttcttcgt ggtccaggac gtcttcctgt ccaagaccgc gcagttcgcg     2100

gacgtggtcc ttccggcctg cccgagcctt gagaaggagg gcacgttcac gaacaccgag     2160

cggcgcatcc agcgcttgta tcgggtgctt gaaccgctgg gagacgcgaa gccggactgg     2220

gagatcattc aaatggtcgc caaccggttt ggcgcccatt ggaactacac atctgcgcgc     2280

gagattttcg aggagatggc gagtgcggcc gatctgttcc ggggggcgtc gtacgaccgc     2340

ctcgagggct acgggagcct gcagtggccc gtgcttcccg acggcaccga cacgccgctc     2400

ctgtacacgg acggcttcgc attccccgac aagaaggcgc ggctctatcc ggtcgactgg     2460

acgccgccca tcgaagtcgg ggaggaatac gatctagagt tgaacaacgg gcgcttgctc     2520

gagcacttcc acgagggcaa catgacgagc cgcgtgcccg gtatccacga aaaagtgccg     2580

gaaaccttcg tcgagatctc gccggagctc gcgaaggagc gcggtgtcca ggacggcgcg     2640

ctggtgcgcc tcgtctcgcc gtacggcagc atcaaggtgc gcgtggccgt gacggatcgc     2700

gtgtccggga aacacgtgta cgttccgctc ttgtcccatg cggacgagga ggcggtcaac     2760

cgcctcacgt cgagcgatca cgacaccgcc acctacacgc ctgcctataa ggaaatgcgc     2820

gtgcgcatgg aggtcatcca atcgtgtggc gagccgccca tcaagcgcgg gaacttccgc     2880

ctgggcaagc cgaacccgca gcccggtgtg aacgtcgagc aaaagtgggc gcgcaaggac     2940

tacgtgccgc tggtgacgga tcgcgcgctt gtgaaggagg gttga                     2985


<210>   853
<211>   974
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   853
Glu Glu Ala Thr Phe Ser Ile Arg Ile Asn Gly Gln Glu Leu Ala Ala 
                5                   10                  15      

Arg Lys Gly Gln Thr Ile Leu Glu Val Ala Asn Ala His Asp Met Tyr 
            20                  25                  30          

Ile Pro Ala Ile Cys Tyr His Pro Asn Leu Gly Ser Ile Gln Thr Cys 
        35                  40                  45              

Asp Thr Cys Phe Val Asn Val Asn Gly Asn Leu Val Arg Ala Cys Ala 
    50                  55                  60                  

Thr Lys Val Glu Pro Gly Met Glu Val Glu Ser Gly Ser Lys Pro Val 
65                  70                  75                  80  

Lys Asp Ala Gln Tyr Glu Ala Met Ser Arg Ile Leu Lys Asn His Glu 
                85                  90                  95      

Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Val Val His 
            100                 105                 110         

Asn Thr Ala Glu His Leu Glu Ile Glu His Gln Lys Tyr Gln Phe Glu 
        115                 120                 125             

Ala Lys Pro Tyr Pro Pro Asp Gln Ser His Pro Phe Tyr Arg Tyr Glu 
    130                 135                 140                 

Pro Asp Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys Gln Asp 
145                 150                 155                 160 

Leu Gln Val Asn Glu Thr Leu Thr Ile Asp Trp Asp Arg Glu Val Pro 
                165                 170                 175     

Arg Val Ile Trp Asp Asn Asp Val Pro Ile Asp Glu Ser Ser Cys Val 
            180                 185                 190         

Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu Met Glu 
        195                 200                 205             

Lys Ser Met Leu Gly Glu Ala Gly Tyr Leu Thr Gly Ile Pro Gln Lys 
    210                 215                 220                 

Val Leu Glu Pro Met Ile Asp Leu Thr Lys Glu Val Glu Pro Gly Tyr 
225                 230                 235                 240 

Lys Glu Ile Phe Ala Ile Ser Glu Met Glu Ala Ala Met Arg Lys Ser 
                245                 250                 255     

Arg Ile Lys Arg Thr Lys Thr Val Cys Thr Tyr Cys Gly Val Gly Cys 
            260                 265                 270         

Ser Phe Glu Ile Trp Thr Lys Gly Arg His Ile Leu Lys Val Glu Pro 
        275                 280                 285             

Gln Glu His Ala Pro Val Asn Gly Ile Ser Thr Cys Val Lys Gly Lys 
    290                 295                 300                 

Phe Gly Trp Asp Phe Val Asn Ser Glu Glu Arg Leu Thr Lys Pro Leu 
305                 310                 315                 320 

Ile Arg Lys Gly Glu Glu Phe Val Glu Ala Ser Trp Asp Glu Ala Leu 
                325                 330                 335     

Asn Leu Ile Ala Ser Lys Leu Gln Glu Ile Lys Lys Gln His Gly Pro 
            340                 345                 350         

Asp Ala Leu Gly Phe Ile Ala Ser Ser Lys Cys Ser Asn Glu Glu Asn 
        355                 360                 365             

Tyr Leu Phe Gln Lys Phe Ala Arg Ala Ile Ile Gly Thr Asn Asn Leu 
    370                 375                 380                 

Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Ser Gly Leu Leu 
385                 390                 395                 400 

Arg Thr Val Gly Ile Gly Gly Asp Ser Gly Thr Ile Arg Asp Ile Gln 
                405                 410                 415     

Gln Ala Asp Leu Val Val Thr Val Gly Ala Asn Pro Ala Glu Ser His 
            420                 425                 430         

Pro Val Leu Ala Thr Arg Ile Lys Arg Ala His Lys Leu His Gly Gln 
        435                 440                 445             

Lys Leu Met Val Val Asp Leu Arg Glu Asn Glu Leu Ala Ser Arg Ala 
    450                 455                 460                 

Asn Leu Phe Ile His Ser Lys Pro Ser Thr Asp Leu Ile Trp Leu Asn 
465                 470                 475                 480 

Ala Val Thr Lys Tyr Ile Leu Asp Gln Gly Trp Glu Asp Lys Ala Phe 
                485                 490                 495     

Leu Glu Ala Arg Val Lys Gly Leu Asp Lys Phe Arg Ala Ser Leu Glu 
            500                 505                 510         

Lys Tyr Thr Leu Ala Phe Ala Glu Glu Lys Thr Gly Ile Ser Lys Glu 
        515                 520                 525             

Asn Leu Ile Lys Met Ala Thr Met Ile His Glu Ala Lys Ser Val Cys 
    530                 535                 540                 

Ile Leu Trp Ala Met Gly Ile Thr Gln His Thr Cys Gly Thr Asp Ala 
545                 550                 555                 560 

Ser Thr Ala Ile Ser Asn Leu Leu Leu Val Thr Gly Asn Tyr Gly Arg 
                565                 570                 575     

Pro Gly Thr Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val Gln Gly 
            580                 585                 590         

Ala Cys Asp Phe Gly Thr Met Pro Ala Trp Phe Pro Gly Tyr Glu Pro 
        595                 600                 605             

Val Glu Asp Asn Glu Val Arg Glu Arg Tyr Glu Lys Ala Trp Gly Val 
    610                 615                 620                 

Lys Leu Pro Glu Asn Pro Gly Leu Asp Asn His Gln Met Ile Gly Gly 
625                 630                 635                 640 

Ile Lys Ser Gly Lys Leu Arg Gly Leu Tyr Leu Phe Gly Glu Glu Met 
                645                 650                 655     

Ala Ile Val Asp Ser Asn Ile Asn Phe Val Glu Glu His Leu Glu Lys 
            660                 665                 670         

Leu Asp Phe Phe Val Val Gln Asp Val Phe Phe Ser Lys Thr Ala Gln 
        675                 680                 685             

Phe Ala Asp Val Ile Leu Pro Ala Ala Pro Ser Leu Glu Lys Glu Gly 
    690                 695                 700                 

Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Phe Tyr Gln Val Phe 
705                 710                 715                 720 

Glu Pro Met Gly Glu Ser Lys Pro Asp Trp Val Ile Phe Gln Glu Leu 
                725                 730                 735     

Ala Asn Lys Met Gly Ala Gln Trp His Tyr Gln His Pro Gly Glu Ile 
            740                 745                 750         

Met Ala Glu Ala Ala Ser Leu Ala Lys Tyr Phe Ala Gly Ile Ser Tyr 
        755                 760                 765             

Glu Arg Leu Glu Gly Phe Asn Ser Gln Ile Trp Pro Val Lys Lys Asp 
    770                 775                 780                 

Gly Thr Ser Thr Pro Leu Leu Tyr Gln Asp Arg Phe Ala Phe Pro Asp 
785                 790                 795                 800 

Gly Lys Ala Arg Leu Val Pro Val Asp Trp Glu Pro Pro Phe Ser Ala 
                805                 810                 815     

Gly Glu Gly Phe Asp Tyr His Leu Asn Asn Gly Arg Leu Leu Glu Gln 
            820                 825                 830         

Phe His Glu Gly Asn Leu Thr Asp Arg Ser Pro Gly Ile His His Lys 
        835                 840                 845             

Val Pro Glu Pro Trp Leu Glu Ile Ser Pro Glu Ala Ala Ser Glu Arg 
    850                 855                 860                 

Gly Ile Lys Asp Gly Ala Leu Val Arg Leu Thr Ser Pro Tyr Gly Lys 
865                 870                 875                 880 

Val Lys Val Arg Ala Val Val Thr Gly Arg Val Gln Gly Lys Glu Leu 
                885                 890                 895     

Tyr Leu Thr Met Asn Ala Arg Lys Glu Asp Glu Met Val Asn Arg Leu 
            900                 905                 910         

Thr Ser Ser Tyr His Asp Arg Val Thr His Thr Pro Asn Tyr Lys Glu 
        915                 920                 925             

Met Gly Val Lys Met Glu Ile Leu Glu Glu Lys Gly Lys Pro Pro Leu 
    930                 935                 940                 

Pro Lys Val Asn His Arg Tyr Gly Asn Arg Ile Pro Gln Ile Ser Val 
945                 950                 955                 960 

Arg Val Glu Glu Lys Trp Lys Arg Asp Asp Phe Ile Pro Ile 
                965                 970                 

<210>   854
<211>   985
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   854
Glu Ala Gln Met Val Thr Val Thr Ile Asn Gly Arg Ala Tyr Arg Ala 
                5                   10                  15      

Lys Pro Gly Met Thr Ile Leu Glu Val Val Asn Glu His Gly Leu Pro 
            20                  25                  30          

His Pro Gln Val Cys Tyr Thr Pro Glu Leu Gly Ala Ile Gln Thr Cys 
        35                  40                  45              

Asp Thr Cys Ile Ala Glu Val Asn Gly Thr Leu Leu Arg Ala Cys Ala 
    50                  55                  60                  

Thr Pro Val Glu Asp Gly Met Val Val Glu Leu Gly Ser Pro Arg Ala 
65                  70                  75                  80  

Lys Ala Ala Gln Lys Glu Ala Met Asp Arg Leu Leu Glu Asn His Leu 
                85                  90                  95      

Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Lys Leu His 
            100                 105                 110         

Asn Thr Ala Glu Met Met Gln Ile Glu His Gln Thr Tyr Pro Tyr Arg 
        115                 120                 125             

Pro Lys Val Asp Pro Ser Glu Val Asp Met Ser His Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Asn Gln Cys Ile Ala Cys Gly Gln Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Asn Glu Thr Leu Ser Ile Asp Trp Glu Ala Glu 
                165                 170                 175     

Arg Pro Arg Val Val Trp Asp Gly Gly Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly Gln Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Glu Ala Gly Phe Leu Thr Gly Leu Asp 
    210                 215                 220                 

Lys Asp Val Leu Asn Pro Met Ile Asp Phe Val Lys Glu Val Glu Pro 
225                 230                 235                 240 

Asn Tyr Thr Ser Ile Phe Ala Ile Ser Glu Ile Glu Ala Ala Met Arg 
                245                 250                 255     

Glu Gln Arg Ile Lys Lys Thr Lys Thr Val Cys Thr Phe Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Glu Val Trp Thr Lys Gly Arg Lys Ile Leu Lys Ile 
        275                 280                 285             

Gln Pro Val Ser Glu Ala Pro Val Asn Ala Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Glu Glu Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Lys Gly Asp Val Phe Val Glu Ser Thr Trp Asp Glu 
                325                 330                 335     

Ala Leu Asp Leu Val Ala Glu Lys Leu Gly Ala Ile Lys Arg Gln Tyr 
            340                 345                 350         

Gly Gly Asn Ala Ile Gly Phe Ile Ser Ser Ser Lys Ile Ser Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Gln Val Phe Glu Thr Asn 
    370                 375                 380                 

Asn Val Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Asp Gly 
385                 390                 395                 400 

Leu Phe Arg Thr Val Gly Met Gly Gly Asp Ser Gly Thr Ile His Asp 
                405                 410                 415     

Ile Ala Thr Ala Gly Leu Val Ile Ile Ile Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Gly His Pro Val Leu Ala Thr Arg Val Lys Arg Ala His Lys Leu Phe 
        435                 440                 445             

Gly Gln Lys Leu Ile Val Ala Asp Leu Arg Arg Asn Glu Met Ala Glu 
    450                 455                 460                 

Arg Ala Asp Leu Phe Ile Arg Pro Lys Gln Gly Thr Asp Gln Val Trp 
465                 470                 475                 480 

Leu Met Ala Val Thr Lys Tyr Ile Ile Asp Gln Gly Trp His Asp Glu 
                485                 490                 495     

Ala Phe Ile Arg Glu Arg Val His Phe Phe Glu Glu Phe Lys Gln Leu 
            500                 505                 510         

Leu Glu Lys Tyr Thr Leu Asp Tyr Ala Glu Gln Val Thr Gly Ile Ala 
        515                 520                 525             

Lys Ala Asp Leu Ile Arg Ile Ala Glu Met Ile His Glu Ala Asp Gly 
    530                 535                 540                 

Thr Cys Val Leu Trp Gly Met Gly Val Thr Gln Asn Thr Gly Gly Ser 
545                 550                 555                 560 

Asp Thr Ser Ala Ala Ile Ser Asn Leu Leu Leu Ala Thr Gly Asn Tyr 
                565                 570                 575     

Gly Arg Pro Gly Ala Gly Ala Phe Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Cys Asp Met Gly Ser Leu Pro Ala Trp Leu Pro Gly Tyr 
        595                 600                 605             

Gln His Val Thr Asp Asp Glu Ala Arg Ala Lys Phe Glu Gln Ala Tyr 
    610                 615                 620                 

Gly Val Arg Ile Asp Ala Lys Pro Gly Leu Asp Asn Ile Gln Met Leu 
625                 630                 635                 640 

Glu Ala Ala Glu Arg Gly Glu Leu Lys Ala Met Tyr Ile Val Gly Glu 
                645                 650                 655     

Asp Met Ala Leu Val Asp Cys Asn Ala Asn His Val Gln Glu Thr Leu 
            660                 665                 670         

Ala Lys Leu Asp Phe Val Val Val Gln Asp Ile Phe Leu Ser Lys Thr 
        675                 680                 685             

Ala Gln Phe Ala Asp Val Ile Leu Pro Ala Ala Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Phe Tyr Gln 
705                 710                 715                 720 

Ala Leu Glu Pro Leu Gly Asp Ser Lys Pro Asp Trp Trp Ile Ile Gln 
                725                 730                 735     

Glu Ile Ala Lys Arg Leu Gly Ala Asp Trp Asn Tyr Ala Gly Pro Lys 
            740                 745                 750         

Glu Ile Met Asp Glu Ile Ala Ser Leu Ala Pro Leu Tyr Ser Gln Ala 
        755                 760                 765             

His Tyr Asp Arg Leu Glu Gly Trp Asn Ser Leu Cys Trp Gly Ser His 
    770                 775                 780                 

Asp Gly Ala Asp Thr Pro Leu Leu Tyr Lys Glu Arg Phe Asn Phe Pro 
785                 790                 795                 800 

Asp Gly Lys Ala Arg Phe Ala Leu Ala Asp Trp Val Glu Pro Val Gln 
                805                 810                 815     

Tyr Pro Glu Glu Tyr Asp Leu Leu Val Asn Asn Gly Arg Leu Leu Glu 
            820                 825                 830         

His Phe His Glu Gly Asn Leu Thr Tyr Lys Ser Lys Gly Ile Glu His 
        835                 840                 845             

Lys Phe Pro Glu Val Phe Val Glu Val Ser Pro Glu Leu Ala Lys Glu 
    850                 855                 860                 

Arg Gly Ile Glu Asp Gly Ala Leu Val Arg Leu Ile Ser Pro Tyr Gly 
865                 870                 875                 880 

Arg Val Lys Val Arg Val Leu Val Thr Asp Arg Val Arg Gly Asn Glu 
                885                 890                 895     

Leu Phe Leu Pro Met His Ser Thr Ala Asn Glu Ser Ala Ile Asn Ile 
            900                 905                 910         

Leu Thr Gly Pro Ala Thr Asp Arg Arg Thr Asn Thr Pro Ala Tyr Lys 
        915                 920                 925             

Gln Ala Arg Val Arg Met Glu Val Ile Glu Arg Ser Gly Lys Thr Pro 
    930                 935                 940                 

Leu Pro Arg Thr Asn Pro Arg Phe Lys Lys Arg His Pro Gln Asn Gly 
945                 950                 955                 960 

Val Glu Val Glu Arg Lys Trp Arg Arg Ser Asp Tyr Val Pro Leu Thr 
                965                 970                 975     

Glu Glu Asn Lys Gly Val Thr Ile Gly 
            980                 985 

<210>   855
<211>   970
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   855
Thr Tyr Gln Val Lys Leu Asn Gly Ala Glu Val Lys Val Ala Ala Gly 
                5                   10                  15      

Asp Glu Thr Thr Ile Leu Gln Leu Leu Gln Asn Ser Ser Val Glu Val 
            20                  25                  30          

Pro Asn Val Cys Tyr His Pro Ser Leu Gly Pro Ile Glu Thr Cys Asp 
        35                  40                  45              

Thr Cys Ile Val Ser Val Asn Gly Glu Leu Val Arg Ser Cys Ser Thr 
    50                  55                  60                  

Lys Leu Asn Asp Gly Asp Ile Ile Asp Thr Val Ser Ala Asp Val Lys 
65                  70                  75                  80  

Glu Ala Gln Val Ile Gly Met Asp Arg Ile Leu Thr Asn His Glu Leu 
                85                  90                  95      

Tyr Cys Thr Val Cys Asp Tyr Asn Asn Gly Gly Cys Glu Val His Asn 
            100                 105                 110         

Thr Val Lys Glu Met Lys Ile Asn His Gln Ser Val Pro Phe Ala Gln 
        115                 120                 125             

Lys Pro Tyr Pro Ala Asp Asn Ser His Pro Phe Tyr Arg Tyr Asp Pro 
    130                 135                 140                 

Asp Gln Cys Ile Leu Cys Gly Arg Cys Val Glu Ala Cys Gln Asp Val 
145                 150                 155                 160 

Gln Val Thr Glu Thr Leu Thr Ile Asp Trp Glu Arg Glu Lys Pro Arg 
                165                 170                 175     

Val Ile Trp Asp Asn Asp Val Pro Ile Asn Glu Ser Ser Cys Val Ser 
            180                 185                 190         

Cys Gly His Cys Ser Thr Val Cys Pro Cys Asn Ala Met Leu Glu Lys 
        195                 200                 205             

Gly Met Glu Gly Glu Ala Gly Tyr Leu Thr Gly Ile Ala Lys Gln Thr 
    210                 215                 220                 

Leu Arg Pro Met Ile Glu Ile Thr Lys Asn Val Glu Thr Gly Tyr Gly 
225                 230                 235                 240 

Ser Ile Leu Ala Ile Ser Asp Met Glu Ala Ala Met Arg Asp Glu Arg 
                245                 250                 255     

Ile Lys Lys Thr Lys Thr Val Cys Thr Tyr Cys Gly Val Gly Cys Ser 
            260                 265                 270         

Phe Asp Val Trp Thr Lys Gly Arg Glu Ile Leu Lys Val Asp Pro Gln 
        275                 280                 285             

Pro Glu Ala Pro Ala Asn Gly Ile Ser Thr Cys Val Lys Gly Lys Phe 
    290                 295                 300                 

Gly Trp Asp Phe Val Asn Ser Glu Glu Arg Leu Thr Lys Pro Leu Ile 
305                 310                 315                 320 

Arg Glu Gly Glu Phe Phe Arg Glu Ala Glu Trp Asp Glu Ala Ile Ser 
                325                 330                 335     

Leu Ile Ala Arg Arg Phe Thr Glu Ile Lys Asn Glu His Gly Ala Gln 
            340                 345                 350         

Ala Met Ser Phe Ile Ser Ser Ser Lys Cys Thr Asn Glu Glu Ser Phe 
        355                 360                 365             

Leu Met Gln Lys Leu Gly Arg Ala Val Ile Gly Thr Asn Asn Ile Asp 
    370                 375                 380                 

Asn Cys Ser Arg Tyr Cys Gln Thr Pro Ala Thr Val Gly Leu Phe Arg 
385                 390                 395                 400 

Thr Val Gly Tyr Gly Gly Asp Ala Gly Ser Ile Arg Asp Ile Gln Met 
                405                 410                 415     

Ser Asp Leu Val Leu Ile Ile Gly Ser Asn Thr Ala Glu Ser His Pro 
            420                 425                 430         

Val Leu Ser Thr Arg Val Lys Arg Ser His Lys Leu Gly Gly Gln Lys 
        435                 440                 445             

Leu Ile Val Ala Asp Leu Arg Lys His Glu Met Ala Asp Arg Ala Asp 
    450                 455                 460                 

Leu Phe Val Gln Pro Lys Ala Gly Thr Asp Ile Val Trp Leu Ser Ala 
465                 470                 475                 480 

Val Ala Lys Tyr Ile Ile Asp Asn Gly Met Ala Asp Glu Glu Phe Leu 
                485                 490                 495     

Ala Glu Lys Val Asn Gly Leu Asp Glu Phe Thr Lys Asn Leu Glu Lys 
            500                 505                 510         

Tyr Thr Met Glu Tyr Ala Ala Glu Val Thr Gly Ile Ala Leu Glu Gln 
        515                 520                 525             

Leu Ile Asp Met Ala Glu Met Ile Gly Arg Ala Lys Ser Val Cys Ala 
    530                 535                 540                 

Leu Trp Ala Met Gly Ile Thr Gln His Met Gly Gly Ser Asp Ala Ser 
545                 550                 555                 560 

Thr Ala Ile Ser Asn Leu Leu Leu Val Thr Gly Asn Tyr Ala Lys Pro 
                565                 570                 575     

Gly Ala Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val Gln Gly Ala 
            580                 585                 590         

Ser Asp Phe Gly Ser Met Pro Asn Met Phe Pro Gly Tyr Gln Glu Val 
        595                 600                 605             

Ala Asp Pro Glu Ile Arg Lys Lys Tyr Glu Leu Ala Trp Gly Thr Glu 
    610                 615                 620                 

Leu Pro Gly Glu Pro Gly Leu Asn Asn His Glu Met Val Glu Gly Ile 
625                 630                 635                 640 

His Ala Gly Thr Leu Lys Ala Met Tyr Leu Lys Gly Glu Asp Met Gly 
                645                 650                 655     

Leu Val Asp Ser Asn Ile Asn His Val His Ala Ala Phe Glu Lys Leu 
            660                 665                 670         

Asp Phe Phe Val Val Gln Asp Ile Phe Leu Ser Lys Thr Ala Glu Phe 
        675                 680                 685             

Ala Asp Val Val Leu Pro Ala Ser Pro Ser Leu Glu Lys Glu Gly Thr 
    690                 695                 700                 

Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Leu Tyr Gln Ala Leu Glu 
705                 710                 715                 720 

Pro Leu Gly Asp Ser Lys Pro Asp Trp Gln Ile Ile Met Glu Ile Ala 
                725                 730                 735     

Asn Ser Leu Gly Ala Gly Trp Asn Tyr Thr His Pro Ser Glu Ile Met 
            740                 745                 750         

Glu Glu Ala Ser Arg Leu Met Pro Leu Tyr Ser Gly Val Thr Tyr Glu 
        755                 760                 765             

Arg Leu Glu Gly Tyr Asn Ser Leu Gln Trp Pro Val Ala Glu Asp Gly 
    770                 775                 780                 

Gln Asp Thr Pro Leu Leu Tyr Thr Glu Arg Phe Pro Phe Glu Asp Gly 
785                 790                 795                 800 

Arg Ala Arg Leu Val Pro Val Asp Trp Thr Lys Pro Leu Glu Phe Glu 
                805                 810                 815     

Glu Glu Tyr Asp Leu His Ile Asn Asn Gly Arg Leu Leu Glu His Phe 
            820                 825                 830         

His Glu Gly Asn Met Thr Tyr Arg Ser Lys Gly Ile Ser Glu Lys Thr 
        835                 840                 845             

Pro Ser Val Phe Leu Glu Val Ser Pro Glu Leu Ala Glu Glu Arg Gly 
    850                 855                 860                 

Leu Glu Ser Gly Thr Leu Val Arg Leu Ser Ser Pro Tyr Gly Asn Val 
865                 870                 875                 880 

Lys Val Gln Cys His Ile Thr Asp Arg Val Lys Gly Lys Glu Val Tyr 
                885                 890                 895     

Leu Pro Met Asn Asp Arg Gly Glu Ala Ala Ile Asn Leu Leu Thr Ser 
            900                 905                 910         

Ser Tyr Ala Asp Lys Asp Thr Asp Thr Pro Ala Tyr Lys Glu Ile Arg 
        915                 920                 925             

Ala Lys Met Glu Ile Leu Lys Ala Lys Gly Glu Asp Pro Leu Pro Arg 
    930                 935                 940                 

Ile Asn His Arg Tyr Gly Asn Pro Gln Pro Gln Ile Gly Val Gln Val 
945                 950                 955                 960 

Gln Lys Lys Trp Ala Arg Lys Asp Tyr Ile 
                965                 970 

<210>   856
<211>   985
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   856
Glu Thr Arg Thr Val Thr Val Thr Ile Asn Gly Arg Pro Tyr His Val 
                5                   10                  15      

Lys Gln Gly Met Thr Ile Leu Glu Thr Val Asn Glu His Gly Leu Pro 
            20                  25                  30          

His Pro Gln Val Cys Tyr Thr Pro Glu Leu Gly Ala Ile Gln Thr Cys 
        35                  40                  45              

Asp Thr Cys Ile Ala Glu Val Asn Gly Thr Leu Leu Arg Ala Cys Ser 
    50                  55                  60                  

Thr Leu Val Glu Asp Gly Met Val Val Glu Leu Ser Ser Pro Arg Ala 
65                  70                  75                  80  

Lys Val Val Gln Lys Glu Ala Met Asp Arg Leu Leu Glu Asn His Leu 
                85                  90                  95      

Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Lys Leu His 
            100                 105                 110         

Asn Thr Thr Glu Met Met Gln Ile Glu His Gln Thr Tyr Pro Tyr Arg 
        115                 120                 125             

Pro Lys Val Asp Pro Ser Glu Val Asp Met Ser His Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Asn Gln Cys Ile Ala Cys Gly Gln Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Asn Glu Thr Leu Ser Ile Asp Trp Glu Ala Glu 
                165                 170                 175     

Arg Pro Arg Val Val Trp Asp Gly Gly Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Glu Ala Gly Phe Met Thr Gly Leu Asp 
    210                 215                 220                 

Gln Asp Val Leu Lys Pro Met Ile Asp Phe Val Lys Glu Val Glu Pro 
225                 230                 235                 240 

Asn Tyr Thr Ser Ile Phe Ala Ile Ser Glu Ile Glu Ala Ala Met Arg 
                245                 250                 255     

Gln Gln Arg Ile Lys Lys Thr Lys Thr Val Cys Thr Phe Cys Gly Val 
            260                 265                 270         

Gly Cys Ser Phe Glu Val Trp Thr Lys Gly Arg Lys Ile Leu Lys Ile 
        275                 280                 285             

Gln Pro Val Ser Glu Ala Pro Val Asn Ala Ile Ser Thr Cys Val Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Ile Asn Ser Glu Glu Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Ile Arg Lys Gly Asp Thr Phe Val Glu Ser Thr Trp Glu Glu 
                325                 330                 335     

Ala Leu Asp Leu Val Ala Glu Lys Leu Gly Ala Ile Lys Gln Gln Tyr 
            340                 345                 350         

Gly Gly Asn Ala Ile Gly Phe Ile Ser Ser Ser Lys Ile Ser Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Gln Val Phe Glu Thr Asn 
    370                 375                 380                 

Asn Val Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Asp Gly 
385                 390                 395                 400 

Leu Phe Arg Thr Val Gly Met Gly Gly Asp Ser Gly Thr Ile Tyr Asp 
                405                 410                 415     

Ile Ala Ser Ala Gly Leu Val Ile Ile Ile Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Gly His Pro Val Ile Ala Thr Arg Val Lys Arg Ala His Lys Leu Phe 
        435                 440                 445             

Gly Gln Lys Leu Ile Val Ala Asp Leu Arg Arg Asn Glu Met Ala Glu 
    450                 455                 460                 

Arg Ala Asp Leu Phe Ile Arg Pro Lys Gln Gly Thr Asp Gln Val Trp 
465                 470                 475                 480 

Leu Met Ala Val Thr Lys Tyr Ile Ile Asp Gln Gly Trp His Asp Glu 
                485                 490                 495     

Ser Phe Ile Arg Glu Arg Val His Phe Phe Asp Glu Phe Lys Gln Leu 
            500                 505                 510         

Leu Glu Lys Tyr Thr Leu Asp Tyr Ala Glu Gln Ile Thr Gly Ile Ala 
        515                 520                 525             

Lys Thr Asp Leu Ile Arg Ile Ala Glu Met Ile His Glu Ala Asp Gly 
    530                 535                 540                 

Thr Cys Val Leu Trp Gly Met Gly Val Thr Gln Asn Thr Gly Gly Ser 
545                 550                 555                 560 

Asp Thr Ser Ala Ala Ile Ser Asn Leu Leu Leu Ala Thr Gly Asn Tyr 
                565                 570                 575     

Gly Arg Pro Gly Ala Gly Ala Phe Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Cys Asp Met Gly Ser Leu Pro Ser Trp Leu Pro Gly Tyr 
        595                 600                 605             

Gln His Val Thr Asp Asp Ala Ala Arg Thr Lys Phe Glu Lys Val Tyr 
    610                 615                 620                 

Gly Val Arg Ile Asp Ala Lys Pro Gly Leu Asp Asn Ile Gln Met Ile 
625                 630                 635                 640 

Glu Ala Ala Glu Arg Gly Asp Leu Lys Ala Met Tyr Ile Ile Gly Glu 
                645                 650                 655     

Asp Met Ala Leu Val Asp Cys Asn Ala Asn His Val Gln Asp Thr Leu 
            660                 665                 670         

Ala Lys Leu Asp Phe Val Val Val Gln Asp Ile Phe Leu Ser Lys Thr 
        675                 680                 685             

Ala Gln Phe Ala Asp Val Ile Leu Pro Ala Ala Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Ile Gln Arg Phe Tyr Gln 
705                 710                 715                 720 

Ala Leu Glu Pro Leu Gly Asp Ser Lys Pro Asp Trp Trp Ile Ile Gln 
                725                 730                 735     

Glu Ile Ala Lys Arg Leu Gly Ala Asp Trp Asn Tyr Ala Gly Pro Ser 
            740                 745                 750         

Glu Ile Met Asp Glu Ile Ala Ser Leu Ala Pro Leu Tyr Ser Gln Ala 
        755                 760                 765             

His Tyr Asp Arg Leu Glu Gly Trp Asn Ser Leu Cys Trp Gly Ser Tyr 
    770                 775                 780                 

Asp Gly Ala Asp Thr Pro Leu Leu Tyr Lys Glu Arg Phe Asn Phe Pro 
785                 790                 795                 800 

Asp Gly Lys Ala Arg Phe Ala Leu Ala Asp Trp Val Glu Pro Val Gln 
                805                 810                 815     

Tyr Pro Glu Glu Tyr Asp Leu Leu Val Asn Asn Gly Arg Leu Leu Glu 
            820                 825                 830         

His Phe His Glu Gly Asn Leu Thr Tyr Lys Ser Lys Gly Ile Gln Arg 
        835                 840                 845             

Lys Phe Pro Asp Ile Phe Val Glu Val Ser Pro Glu Leu Ala Lys Glu 
    850                 855                 860                 

Arg Gly Ile Ser Asp Gly Ala Leu Val Arg Leu Ile Ser Pro Tyr Gly 
865                 870                 875                 880 

Arg Val Lys Val Arg Val Leu Val Thr Asp Arg Val Arg Gly Asn Glu 
                885                 890                 895     

Leu Phe Leu Pro Met His Ser Thr Ala Asn Glu Ser Ala Ile Asn Ile 
            900                 905                 910         

Leu Thr Gly Pro Gln Thr Asp His Arg Thr Asn Thr Pro Ala Tyr Lys 
        915                 920                 925             

Gln Ala Arg Val Arg Met Glu Val Leu Glu Arg Ser Gly Glu Thr Pro 
    930                 935                 940                 

Leu Pro Cys Thr Asn Pro Arg Phe Gln Lys Arg His Pro Gln Asn Gly 
945                 950                 955                 960 

Val Glu Val Glu Arg Lys Trp Arg Arg Arg Asp Tyr Val Pro Leu Thr 
                965                 970                 975     

Glu Ala Glu Lys Glu Val Lys Ile Gly 
            980                 985 

<210>   857
<211>   975
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   857
Glu Thr Lys Ser Ile His Ile Thr Ile Asp Gly Arg Asp Tyr Glu Ala 
                5                   10                  15      

Arg Pro Gly Glu Lys Ile Ile Asp Val Ile Asn Arg Asn Asp Ile Phe 
            20                  25                  30          

His Pro Gln Ile Cys Tyr Tyr Pro Glu Val Asp Pro Ile Gln Thr Cys 
        35                  40                  45              

Asp Thr Cys Ile Ala Glu Val Asn Gly Glu Leu Met Arg Thr Cys Ser 
    50                  55                  60                  

Thr Val Ala Glu Asp Gly Met Val Val Arg Leu Ser Asp Asp Arg Ser 
65                  70                  75                  80  

Glu Ala Ala Arg His Glu Ala Met Asp Arg Ile Leu Ala Asn His Leu 
                85                  90                  95      

Leu Tyr Cys Thr Val Cys Asp Asn Asn Asn Gly Asn Cys Ile Val His 
            100                 105                 110         

Asn Thr Thr Glu Lys Met Gly Ile Glu His Gln Lys Tyr Pro Phe Thr 
        115                 120                 125             

Pro Lys Thr Asp Ala Ser Gly Val Asp Tyr Ser Asn Pro Phe Tyr Arg 
    130                 135                 140                 

Tyr Asp Pro Asn Gln Cys Ile Ala Cys Gly Arg Cys Val Glu Ala Cys 
145                 150                 155                 160 

Gln Asn Leu Gln Val Asn Glu Thr Leu Ser Ile Asp Trp Glu Ala Glu 
                165                 170                 175     

Arg Pro Arg Val Ile Trp Asp Asn Gly Val Pro Ile Asn Glu Ser Ser 
            180                 185                 190         

Cys Val Ser Cys Gly His Cys Val Thr Val Cys Pro Cys Asn Ala Leu 
        195                 200                 205             

Met Glu Lys Ser Met Leu Gly Glu Ala Gly Tyr Leu Thr Gly Leu Glu 
    210                 215                 220                 

Glu Asp Leu Leu Asp Pro Met Ile Asp Leu Val Lys Lys Val Glu Pro 
225                 230                 235                 240 

Gly Tyr Gly Ser Ile Phe Ala Ile Ser Glu Ile Glu Ala Ser Met Arg 
                245                 250                 255     

Glu Gln Arg Thr Lys Lys Thr Lys Thr Val Cys Thr Phe Cys Gly Val 
            260                 265                 270         

Gly Cys Thr Phe Glu Val Trp Thr Lys Gly Arg Lys Ile Leu Lys Ile 
        275                 280                 285             

Glu Pro Lys His Glu Gly Pro Val Asn Ala Ile Ser Thr Cys Ile Lys 
    290                 295                 300                 

Gly Lys Phe Gly Trp Asp Phe Val Asn Ser Asp Lys Arg Leu Thr Lys 
305                 310                 315                 320 

Pro Leu Val Arg Lys Asp Gly Lys Phe Val Glu Thr Ser Trp Asp Glu 
                325                 330                 335     

Ala Leu Ser Val Val Ala Ser Arg Leu Lys Glu Ile His Ser Gln Tyr 
            340                 345                 350         

Gly Lys Asp Ala Val Gly Phe Ile Ser Ser Ser Lys Val Thr Asn Glu 
        355                 360                 365             

Glu Asn Tyr Leu Met Gln Lys Leu Ala Arg Gln Val Phe Glu Thr Asn 
    370                 375                 380                 

Asn Val Asp Asn Cys Ser Arg Tyr Cys Gln Ser Pro Ala Thr Asp Gly 
385                 390                 395                 400 

Leu Leu Arg Thr Val Gly Met Gly Gly Asp Ser Gly Thr Ile Lys Asp 
                405                 410                 415     

Ile Ala Ser Ala Gly Leu Val Ile Ile Val Gly Ala Asn Pro Ala Glu 
            420                 425                 430         

Ala His Pro Val Leu Ala Thr Arg Ile Lys Arg Ala His Lys Leu His 
        435                 440                 445             

Gly Gln Lys Leu Ile Val Ala Asp Met Arg Lys Asn Glu Met Ala Glu 
    450                 455                 460                 

Arg Ala Asp Leu Phe Ile His Pro Asn Gln Gly Thr Asp Gln Val Trp 
465                 470                 475                 480 

Leu Met Ala Val Thr Lys Tyr Ile Ile Asp Gln Gly Trp His Asp Glu 
                485                 490                 495     

Asn Phe Ile Ala Glu Lys Val Asn Phe Phe Asp Glu Phe Lys Glu Thr 
            500                 505                 510         

Leu Glu Lys Tyr Thr Leu Asp Tyr Ala Glu Lys Met Thr Gly Ile Pro 
        515                 520                 525             

Lys Glu Thr Leu Ile Gln Ile Ala Glu Met Ile His Gln Ala Asp Gly 
    530                 535                 540                 

Thr Cys Ile Leu Trp Gly Met Gly Val Thr Gln Asn Thr Gly Gly Ser 
545                 550                 555                 560 

Asp Thr Ser Ala Ala Ile Ser Asn Leu Leu Leu Ala Thr Gly Asn Tyr 
                565                 570                 575     

Thr Arg Pro Gly Thr Gly Ala Tyr Pro Leu Arg Gly His Asn Asn Val 
            580                 585                 590         

Gln Gly Ala Cys Asp Met Gly Thr Leu Pro Gly Trp Leu Pro Gly Tyr 
        595                 600                 605             

Gln His Val Glu Asp Asp Ala Ala Arg Glu Lys Phe Glu Lys Ala Tyr 
    610                 615                 620                 

Gly Val Lys Ile Ser Asn Lys Pro Gly Leu Asn Asn Ile Glu Met Leu 
625                 630                 635                 640 

His Ala Ile Ala Ala Gly Gln Leu Lys Ala Met Tyr Ile Ile Gly Glu 
                645                 650                 655     

Asp Met Ala Leu Val Asp Ser Asp Ala Asn His Val Ser Glu Glu Leu 
            660                 665                 670         

Ser Asn Leu Asp Phe Leu Val Val Gln Asp Val Phe Phe Ser Lys Thr 
        675                 680                 685             

Ala Gln Tyr Ala Asp Val Ile Leu Pro Ala Ala Pro Ser Leu Glu Lys 
    690                 695                 700                 

Glu Gly Thr Phe Thr Asn Thr Glu Arg Arg Val Gln Arg Leu Tyr Gln 
705                 710                 715                 720 

Ala Leu Pro Ala Leu Gly Glu Ser Lys Pro Asp Trp Trp Ile Ile Gln 
                725                 730                 735     

Glu Val Ala Lys Arg Leu Gly Ala Asp Trp Asn Tyr Ser His Pro Gly 
            740                 745                 750         

Glu Ile Phe Ala Glu Met Ala Ser Leu Thr Pro Leu Phe Ala Gln Ala 
        755                 760                 765             

Asp Tyr Asp Lys Leu Glu Gly Trp Asn Ser Phe Leu Trp Gly Ser Leu 
    770                 775                 780                 

Asp Gly Ala Asn Thr Pro Leu Leu Tyr Lys Asp Gly Phe Pro Phe Pro 
785                 790                 795                 800 

Asp Gly Lys Ala Arg Phe Ala Leu Thr Asp Trp Val Lys Pro Ala Glu 
                805                 810                 815     

Phe Pro Glu Gln Tyr Asp Leu His Ile Asn Asn Gly Arg Met Leu Glu 
            820                 825                 830         

Gln Phe His Glu Gly Asn Leu Thr Asn Lys Ser Glu Gly Ile Glu Ser 
        835                 840                 845             

Lys Val Pro Gly Val Phe Val Glu Val Ser Pro Glu Leu Ala Lys Glu 
    850                 855                 860                 

Arg Asn Leu Asp Thr Gly Asp Leu Val Arg Val Thr Ser Pro Phe Gly 
865                 870                 875                 880 

Ser Leu Gln Leu His Val Leu Val Thr Asp Arg Val Gln Gly Lys Glu 
                885                 890                 895     

Leu Tyr Leu Pro Met His Ser Thr Glu Lys Glu Ser Ala Ile Asn Phe 
            900                 905                 910         

Leu Thr Gly Pro Ile Tyr Asp Lys Arg Gln Ser Thr Pro Ala Phe Lys 
        915                 920                 925             

Gln Thr Lys Val Lys Met Glu Leu Ile Arg Lys Gly Gly Glu Ser Pro 
    930                 935                 940                 

Leu Pro Lys Ser Asn His Arg Asp Lys Lys Arg Asn Pro Thr Arg Gly 
945                 950                 955                 960 

Val Glu Val Glu Arg Lys Trp Gln Arg Glu Gly Tyr Gln Pro Leu 
                965                 970                 975 

<210>   858
<211>   994
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 851

<400>   858
Met Ile Asp Ile Arg Thr Glu Ala Gln Ala Glu Ala Arg Thr Val Gln 
                5                   10                  15      

Leu Glu Ile Asp Gly Lys Glu Val Thr Val Glu Arg Gly Ala Ser Val 
            20                  25                  30          

Leu Asp Ala Ile Leu Ser Thr Gly Gln Glu His Pro His Val Cys Tyr 
        35                  40                  45              

His Pro Ala Leu Gly Pro Ile Glu Thr Cys Asp Thr Cys Ile Val Glu 
    50                  55                  60                  

Ile Asp Gly Lys Leu Met Arg Ala Cys Ser Thr Pro Val Glu Asp Gly 
65                  70                  75                  80  

Met Ala Val Arg Thr Lys Ser Val Ala Ala Arg Tyr Ala Arg Lys Glu 
                85                  90                  95      

Ala Met Asp Arg Ile Leu Lys Asn His Glu Leu Tyr Cys Thr Val Cys 
            100                 105                 110         

Asp Asn Asn Asn Gly Asn Cys Val Leu His Asn Thr Val Met Gln Met 
        115                 120                 125             

Gly Val Glu His Gln Ala Tyr Pro Phe Thr Pro Lys Pro Tyr Glu Val 
    130                 135                 140                 

Asp Met Ser Asn Pro Phe Tyr Arg Tyr Asp Pro Gln Gln Cys Ile Leu 
145                 150                 155                 160 

Cys Gly Arg Cys Val Glu Ala Cys Gln Asn Leu Gln Val Ser Glu Val 
                165                 170                 175     

Leu Ser Ile Ala Trp Asp Arg Glu Val Pro Arg Val Ile Trp Asp Asn 
            180                 185                 190         

Asp Val Pro Ile Asn Glu Ser Ser Cys Val Ser Cys Gly His Cys Val 
        195                 200                 205             

Thr Val Cys Pro Thr Asn Ala Leu Met Glu Lys Ser Met Leu Gly Glu 
    210                 215                 220                 

Ala Gly Phe Leu Thr Gly Ile Glu Lys Pro Thr Leu Asp Lys Met Ile 
225                 230                 235                 240 

Asp Ile Thr Lys Lys Val Glu Pro Gly Tyr Ser Ser Ile Phe Val Val 
                245                 250                 255     

Ser Glu Ile Glu His Glu Met Arg Glu Ala Arg Ile Arg Lys Thr Lys 
            260                 265                 270         

Thr Val Cys Thr Tyr Cys Gly Val Gly Cys Ala Phe Asp Val Trp Thr 
        275                 280                 285             

Lys Asp Arg His Ile Leu Lys Val Glu Pro Gln Met Glu Ala Pro Val 
    290                 295                 300                 

Asn Gln Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp Asp Phe Val 
305                 310                 315                 320 

Asn Ser Pro Asp Arg Leu Thr Lys Pro Leu Val Arg Lys Gly Asp Arg 
                325                 330                 335     

Phe Val Glu Val Ser Trp Asp Glu Ala Leu Asp Val Ile Glu Arg Arg 
            340                 345                 350         

Ile Lys Glu Ile Gln Ala Lys His Gly Tyr Asp Ala Val Ala Phe Ile 
        355                 360                 365             

Ser Ser Ser Lys Thr Thr Asn Glu Glu Asn Tyr Leu Met Gln Lys Leu 
    370                 375                 380                 

Ala Arg Ala Val Met His Thr Asn Asn Ile Asp Asn Cys Ser Arg Tyr 
385                 390                 395                 400 

Cys Gln Ser Pro Ala Thr Glu Ala Leu Arg Arg Thr Met Gly Leu Gly 
                405                 410                 415     

Gly Asp Thr Gly Ser Ile Lys Asp Leu Glu Leu Ala Asp Leu Val Leu 
            420                 425                 430         

Ile Val Gly Ala Asn Pro Ala Glu Ala His Pro Val Leu Ser Thr Arg 
        435                 440                 445             

Leu Arg Arg Ala Gln Lys Lys Arg Gly Gln Lys His Ile Val Ala Asp 
    450                 455                 460                 

Val Arg Arg Asn Ile Met Ala Thr Arg Ala Asp Leu Phe Ile Gln Pro 
465                 470                 475                 480 

Arg Gln Gly Thr Asp Leu Val Trp Leu Ser Ala Val Thr Lys Tyr Ile 
                485                 490                 495     

Ile Asp Gln Gly Arg His Asp Glu Ala Phe Leu Arg Asp Arg Val Asn 
            500                 505                 510         

Gly Phe Asp Glu Tyr Val Gln Ser Leu Glu Lys Phe Thr Leu Asp Tyr 
        515                 520                 525             

Ala Ser Glu Ile Cys Gly Leu Lys Lys Glu Glu Leu Val Arg Val Ala 
    530                 535                 540                 

Glu Met Ile Met Glu Ala Lys Arg Val Ala Val Cys Trp Ala Met Gly 
545                 550                 555                 560 

Val Thr Gln His Arg Gly Gly Ser Asp Thr Ser Thr Ala Ile Cys Asn 
                565                 570                 575     

Leu Leu Leu Val Thr Gly Asn Val Ala Arg Pro Gly Thr Gly Ala Tyr 
            580                 585                 590         

Pro Leu Arg Gly His Asn Asn Val Gln Gly Ala Gly Asp Met Gly Cys 
        595                 600                 605             

Ala Pro Pro Phe Leu Pro Gly Tyr Glu Arg Val Asp Asn Glu Glu Gln 
    610                 615                 620                 

Arg Arg Lys Trp Glu Lys Leu Trp Gly Val Glu Leu Pro Thr Thr Pro 
625                 630                 635                 640 

Gly Leu Asn Asn His Gln Met Val Asp Ala Ile His Glu Gly Lys Leu 
                645                 650                 655     

Lys Ala Met Tyr Leu Cys Gly Glu Asp Met Ala Val Val Asp Ser Asn 
            660                 665                 670         

Ala Asn Tyr Val Glu Asp Ala Phe Arg Lys Leu Glu Phe Phe Val Val 
        675                 680                 685             

Gln Asp Val Phe Leu Ser Lys Thr Ala Gln Phe Ala Asp Val Val Leu 
    690                 695                 700                 

Pro Ala Cys Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr Asn Thr Glu 
705                 710                 715                 720 

Arg Arg Ile Gln Arg Leu Tyr Arg Val Leu Glu Pro Leu Gly Asp Ala 
                725                 730                 735     

Lys Pro Asp Trp Glu Ile Ile Gln Met Val Ala Asn Arg Phe Gly Ala 
            740                 745                 750         

His Trp Asn Tyr Thr Ser Ala Arg Glu Ile Phe Glu Glu Met Ala Ser 
        755                 760                 765             

Ala Ala Asp Leu Phe Arg Gly Ala Ser Tyr Asp Arg Leu Glu Gly Tyr 
    770                 775                 780                 

Gly Ser Leu Gln Trp Pro Val Leu Pro Asp Gly Thr Asp Thr Pro Leu 
785                 790                 795                 800 

Leu Tyr Thr Asp Gly Phe Ala Phe Pro Asp Lys Lys Ala Arg Leu Tyr 
                805                 810                 815     

Pro Val Asp Trp Thr Pro Pro Ile Glu Val Gly Glu Glu Tyr Asp Leu 
            820                 825                 830         

Glu Leu Asn Asn Gly Arg Leu Leu Glu His Phe His Glu Gly Asn Met 
        835                 840                 845             

Thr Ser Arg Val Pro Gly Ile His Glu Lys Val Pro Glu Thr Phe Val 
    850                 855                 860                 

Glu Ile Ser Pro Glu Leu Ala Lys Glu Arg Gly Val Gln Asp Gly Ala 
865                 870                 875                 880 

Leu Val Arg Leu Val Ser Pro Tyr Gly Ser Ile Lys Val Arg Val Ala 
                885                 890                 895     

Val Thr Asp Arg Val Ser Gly Lys His Val Tyr Val Pro Leu Leu Ser 
            900                 905                 910         

His Ala Asp Glu Glu Ala Val Asn Arg Leu Thr Ser Ser Asp His Asp 
        915                 920                 925             

Thr Ala Thr Tyr Thr Pro Ala Tyr Lys Glu Met Arg Val Arg Met Glu 
    930                 935                 940                 

Val Ile Gln Ser Cys Gly Glu Pro Pro Ile Lys Arg Gly Asn Phe Arg 
945                 950                 955                 960 

Leu Gly Lys Pro Asn Pro Gln Pro Gly Val Asn Val Glu Gln Lys Trp 
                965                 970                 975     

Ala Arg Lys Asp Tyr Val Pro Leu Val Thr Asp Arg Ala Leu Val Lys 
            980                 985                 990         

Glu Gly 
        

<210>   859
<211>   994
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 851

<400>   859
Met Ile Asp Ile Arg Thr Glu Ala Gln Ala Glu Ala Arg Thr Val Gln 
                5                   10                  15      

Leu Glu Ile Asp Gly Lys Glu Val Thr Val Glu Arg Gly Ala Ser Val 
            20                  25                  30          

Leu Asp Ala Ile Leu Ser Thr Gly Gln Glu His Pro His Val Cys Tyr 
        35                  40                  45              

His Pro Ala Leu Gly Pro Ile Glu Thr Cys Asp Thr Cys Ile Val Glu 
    50                  55                  60                  

Ile Asp Gly Lys Leu Met Arg Ala Cys Ser Thr Pro Val Glu Asp Gly 
65                  70                  75                  80  

Met Ala Val Arg Thr Lys Ser Val Ala Ala Arg Tyr Ala Arg Lys Glu 
                85                  90                  95      

Ala Met Asp Arg Ile Leu Lys Asn His Glu Leu Tyr Cys Thr Val Cys 
            100                 105                 110         

Asp Asn Asn Asn Gly Asn Cys Val Leu His Asn Thr Val Met Gln Met 
        115                 120                 125             

Gly Val Glu His Gln Ala Tyr Pro Phe Thr Pro Lys Pro Tyr Glu Val 
    130                 135                 140                 

Asp Met Ser Asn Pro Phe Tyr Arg Tyr Asp Pro Gln Gln Cys Ile Leu 
145                 150                 155                 160 

Cys Gly Arg Cys Val Glu Ala Cys Gln Asn Leu Gln Val Ser Glu Val 
                165                 170                 175     

Leu Ser Ile Ala Trp Asp Arg Glu Val Pro Arg Val Ile Trp Asp Asn 
            180                 185                 190         

Asp Val Pro Ile Asn Glu Ser Ser Cys Val Ser Cys Gly His Cys Val 
        195                 200                 205             

Thr Val Cys Pro Thr Asn Ala Leu Met Glu Lys Ser Met Leu Gly Glu 
    210                 215                 220                 

Ala Gly Phe Leu Thr Gly Ile Glu Lys Pro Thr Leu Asp Lys Met Ile 
225                 230                 235                 240 

Asp Ile Thr Lys Lys Val Glu Pro Gly Tyr Ser Ser Ile Phe Val Val 
                245                 250                 255     

Ser Glu Ile Glu His Glu Met Arg Glu Ala Arg Ile Arg Lys Thr Lys 
            260                 265                 270         

Thr Val Cys Thr Tyr Cys Gly Val Gly Cys Ala Phe Asp Val Trp Thr 
        275                 280                 285             

Lys Asp Arg His Ile Leu Lys Val Glu Pro Gln Met Glu Ala Pro Val 
    290                 295                 300                 

Asn Gln Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp Asp Phe Val 
305                 310                 315                 320 

Asn Ser Pro Asp Arg Leu Thr Lys Pro Leu Val Arg Lys Gly Asp Arg 
                325                 330                 335     

Phe Val Glu Val Ser Trp Asp Glu Ala Leu Asp Val Ile Glu Arg Arg 
            340                 345                 350         

Ile Lys Glu Ile Gln Ala Lys His Gly Tyr Asp Ala Val Ala Phe Ile 
        355                 360                 365             

Ser Ser Ser Lys Thr Thr Asn Glu Glu Asn Tyr Leu Met Gln Lys Leu 
    370                 375                 380                 

Ala Arg Ala Val Met His Thr Asn Asn Ile Asp Asn Cys Ser Arg Tyr 
385                 390                 395                 400 

Cys Gln Ser Pro Ala Thr Glu Ala Leu Arg Arg Thr Met Gly Leu Gly 
                405                 410                 415     

Gly Asp Thr Gly Ser Ile Lys Asp Leu Glu Leu Ala Asp Leu Val Leu 
            420                 425                 430         

Ile Val Gly Ala Asn Pro Ala Glu Ala His Pro Val Leu Ser Thr Arg 
        435                 440                 445             

Leu Arg Arg Ala Gln Lys Lys Arg Gly Gln Lys His Ile Val Ala Asp 
    450                 455                 460                 

Val Arg Arg Asn Ile Met Ala Thr Arg Ala Asp Leu Phe Ile Gln Pro 
465                 470                 475                 480 

Arg Gln Gly Thr Asp Leu Val Trp Leu Ser Ala Val Thr Lys Tyr Ile 
                485                 490                 495     

Ile Asp Gln Gly Arg His Asp Glu Ala Phe Leu Arg Asp Arg Val Asn 
            500                 505                 510         

Gly Phe Asp Glu Tyr Val Gln Ser Leu Glu Lys Phe Thr Leu Asp Tyr 
        515                 520                 525             

Ala Ser Glu Ile Cys Gly Leu Arg Lys Glu Glu Leu Val Arg Val Ala 
    530                 535                 540                 

Glu Met Ile Met Glu Ala Lys Arg Val Ala Val Cys Trp Ala Met Gly 
545                 550                 555                 560 

Val Thr Gln His Arg Gly Gly Ser Asp Thr Ser Thr Ala Ile Cys Asn 
                565                 570                 575     

Leu Leu Leu Val Thr Gly Asn Val Ala Arg Pro Gly Thr Gly Ala Tyr 
            580                 585                 590         

Pro Leu Arg Gly His Asn Asn Val Gln Gly Ala Gly Asp Met Gly Cys 
        595                 600                 605             

Ala Pro Pro Phe Leu Pro Gly Tyr Glu Arg Val Asp Asn Glu Glu Gln 
    610                 615                 620                 

Arg Arg Lys Trp Glu Lys Leu Trp Gly Val Glu Leu Pro Thr Thr Pro 
625                 630                 635                 640 

Gly Leu Asn Asn His Gln Met Val Asp Ala Ile His Glu Gly Lys Leu 
                645                 650                 655     

Lys Ala Met Tyr Leu Cys Gly Glu Asp Met Ala Val Val Asp Ser Asn 
            660                 665                 670         

Ala Asn Tyr Val Glu Asp Ala Phe Arg Lys Leu Glu Phe Phe Val Val 
        675                 680                 685             

Gln Asp Val Phe Leu Ser Lys Thr Ala Gln Phe Ala Asp Val Val Leu 
    690                 695                 700                 

Pro Ala Cys Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr Asn Thr Glu 
705                 710                 715                 720 

Arg Arg Ile Gln Arg Leu Tyr Arg Val Leu Glu Pro Leu Gly Asp Ala 
                725                 730                 735     

Lys Pro Asp Trp Glu Ile Ile Gln Met Val Ala Asn Arg Phe Gly Ala 
            740                 745                 750         

His Trp Asn Tyr Thr Ser Ala Arg Glu Ile Phe Glu Glu Met Ala Ser 
        755                 760                 765             

Ala Ala Asp Leu Phe Arg Gly Ala Ser Tyr Asp Arg Leu Glu Gly Tyr 
    770                 775                 780                 

Gly Ser Leu Gln Trp Pro Val Leu Pro Asp Gly Thr Asp Thr Pro Leu 
785                 790                 795                 800 

Leu Tyr Thr Asp Gly Phe Ala Phe Pro Asp Lys Lys Ala Arg Leu Tyr 
                805                 810                 815     

Pro Val Asp Trp Thr Pro Pro Ile Glu Val Gly Glu Glu Tyr Asp Leu 
            820                 825                 830         

Glu Leu Asn Asn Gly Arg Leu Leu Glu His Phe His Glu Gly Asn Met 
        835                 840                 845             

Thr Ser Arg Val Pro Gly Ile His Glu Lys Val Pro Glu Thr Phe Val 
    850                 855                 860                 

Glu Ile Ser Pro Glu Leu Ala Lys Glu Arg Gly Val Gln Asp Gly Ala 
865                 870                 875                 880 

Leu Val Arg Leu Val Ser Pro Tyr Gly Ser Ile Lys Val Arg Val Ala 
                885                 890                 895     

Val Thr Asp Arg Val Ser Gly Lys His Val Tyr Val Pro Leu Leu Ser 
            900                 905                 910         

His Ala Asp Glu Glu Ala Val Asn Arg Leu Thr Ser Ser Asp His Asp 
        915                 920                 925             

Thr Ala Thr Tyr Thr Pro Ala Tyr Lys Glu Met Arg Val Arg Met Glu 
    930                 935                 940                 

Val Ile Gln Ser Cys Gly Glu Pro Pro Ile Lys Arg Gly Asn Phe Arg 
945                 950                 955                 960 

Leu Gly Lys Pro Asn Pro Gln Pro Gly Val Asn Val Glu Gln Lys Trp 
                965                 970                 975     

Ala Arg Lys Asp Tyr Val Pro Leu Val Thr Asp Arg Ala Leu Val Lys 
            980                 985                 990         

Asp Gly 
        

<210>   860
<211>   994
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 851

<400>   860
Met Ile Asp Ile Arg Thr Glu Ala Gln Ala Glu Ala Arg Thr Val Gln 
                5                   10                  15      

Leu Glu Ile Asp Gly Lys Glu Val Thr Val Glu Arg Gly Ala Ser Val 
            20                  25                  30          

Leu Asp Ala Ile Leu Ser Thr Gly Gln Glu His Pro His Val Cys Tyr 
        35                  40                  45              

His Pro Ala Leu Gly Pro Ile Glu Thr Cys Asp Thr Cys Ile Val Glu 
    50                  55                  60                  

Ile Asp Gly Lys Leu Met Arg Ala Cys Ser Thr Pro Val Glu Asp Gly 
65                  70                  75                  80  

Met Ala Val Arg Thr Lys Ser Val Ala Ala Arg Tyr Ala Arg Lys Glu 
                85                  90                  95      

Ala Met Asp Arg Ile Leu Lys Asn His Glu Leu Tyr Cys Thr Val Cys 
            100                 105                 110         

Asp Asn Asn Asn Gly Asn Cys Val Leu His Asn Thr Val Met Gln Met 
        115                 120                 125             

Gly Val Glu His Gln Ala Tyr Pro Phe Thr Pro Lys Pro Tyr Glu Val 
    130                 135                 140                 

Asp Met Ser Asn Pro Phe Tyr Arg Tyr Asp Pro Gln Gln Cys Ile Leu 
145                 150                 155                 160 

Cys Gly Arg Cys Val Glu Ala Cys Gln Asn Leu Gln Val Ser Glu Val 
                165                 170                 175     

Leu Ser Ile Ala Trp Asp Arg Glu Val Pro Arg Val Ile Trp Asp Asn 
            180                 185                 190         

Asp Val Pro Ile Asn Glu Ser Ser Cys Val Ser Cys Gly His Cys Val 
        195                 200                 205             

Thr Val Cys Pro Thr Asn Ala Leu Met Glu Lys Ser Met Leu Gly Glu 
    210                 215                 220                 

Ala Gly Phe Leu Thr Gly Ile Glu Lys Pro Thr Leu Asp Lys Met Ile 
225                 230                 235                 240 

Asp Ile Thr Lys Lys Val Glu Pro Gly Tyr Ser Ser Ile Phe Val Val 
                245                 250                 255     

Ser Glu Ile Glu His Glu Met Arg Glu Ala Arg Ile Arg Lys Thr Lys 
            260                 265                 270         

Thr Val Cys Thr Tyr Cys Gly Val Gly Cys Ala Phe Asp Val Trp Thr 
        275                 280                 285             

Lys Asp Arg His Ile Leu Lys Val Glu Pro Gln Met Glu Ala Pro Val 
    290                 295                 300                 

Asn Gln Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp Asp Phe Val 
305                 310                 315                 320 

Asn Ser Pro Asp Arg Leu Thr Lys Pro Leu Val Arg Lys Gly Asp Arg 
                325                 330                 335     

Phe Ile Glu Val Ser Trp Asp Glu Ala Leu Asp Val Ile Glu Arg Arg 
            340                 345                 350         

Ile Lys Glu Ile Gln Ala Lys His Gly Tyr Asp Ala Val Ala Phe Ile 
        355                 360                 365             

Ser Ser Ser Lys Thr Thr Asn Glu Glu Asn Tyr Leu Met Gln Lys Leu 
    370                 375                 380                 

Ala Arg Ala Val Met His Thr Asn Asn Ile Asp Asn Cys Ser Arg Tyr 
385                 390                 395                 400 

Cys Gln Ser Pro Ala Thr Glu Ala Leu Arg Arg Thr Met Gly Leu Gly 
                405                 410                 415     

Gly Asp Thr Gly Ser Ile Lys Asp Leu Glu Leu Ala Asp Leu Val Leu 
            420                 425                 430         

Ile Val Gly Ala Asn Pro Ala Glu Ala His Pro Val Leu Ser Thr Arg 
        435                 440                 445             

Leu Arg Arg Ala Gln Lys Lys Arg Gly Gln Lys His Ile Val Ala Asp 
    450                 455                 460                 

Val Arg Arg Asn Ile Met Ala Thr Arg Ala Asp Leu Phe Ile Gln Pro 
465                 470                 475                 480 

Arg Gln Gly Thr Asp Leu Val Trp Leu Ser Ala Val Thr Lys Tyr Ile 
                485                 490                 495     

Ile Asp Gln Gly Arg His Asp Glu Ala Phe Leu Arg Asp Arg Val Asn 
            500                 505                 510         

Gly Phe Asp Glu Tyr Val Gln Ser Leu Glu Lys Phe Thr Leu Asp Tyr 
        515                 520                 525             

Ala Ser Glu Ile Cys Gly Leu Arg Lys Glu Glu Leu Val Arg Val Ala 
    530                 535                 540                 

Glu Met Ile Met Glu Ala Lys Arg Val Ala Val Cys Trp Ala Met Gly 
545                 550                 555                 560 

Val Thr Gln His Arg Gly Gly Ser Asp Thr Ser Thr Ala Ile Cys Asn 
                565                 570                 575     

Leu Leu Leu Val Thr Gly Asn Val Ala Arg Pro Gly Thr Gly Ala Tyr 
            580                 585                 590         

Pro Leu Arg Gly His Asn Asn Val Gln Gly Ala Gly Asp Met Gly Cys 
        595                 600                 605             

Ala Pro Pro Phe Leu Pro Gly Tyr Glu Arg Val Asp Asn Glu Glu Gln 
    610                 615                 620                 

Arg Arg Lys Trp Glu Lys Leu Trp Gly Val Glu Leu Pro Thr Thr Pro 
625                 630                 635                 640 

Gly Leu Asn Asn His Gln Met Val Asp Ala Ile His Glu Gly Lys Leu 
                645                 650                 655     

Lys Ala Met Tyr Leu Cys Gly Glu Asp Met Ala Val Val Asp Ser Asn 
            660                 665                 670         

Ala Asn Tyr Val Glu Asp Ala Phe Arg Lys Leu Glu Phe Phe Val Val 
        675                 680                 685             

Gln Asp Val Phe Leu Ser Lys Thr Ala Gln Phe Ala Asp Val Val Leu 
    690                 695                 700                 

Pro Ala Cys Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr Asn Thr Glu 
705                 710                 715                 720 

Arg Arg Ile Gln Arg Leu Tyr Arg Val Leu Glu Pro Leu Gly Asp Ala 
                725                 730                 735     

Lys Pro Asp Trp Glu Ile Ile Gln Met Val Ala Asn Arg Phe Gly Ala 
            740                 745                 750         

His Trp Asn Tyr Thr Ser Ala Arg Glu Ile Phe Glu Glu Met Ala Ser 
        755                 760                 765             

Ala Ala Asp Leu Phe Arg Gly Ala Ser Tyr Asp Arg Leu Glu Gly Tyr 
    770                 775                 780                 

Gly Ser Leu Gln Trp Pro Val Leu Pro Asp Gly Thr Asp Thr Pro Leu 
785                 790                 795                 800 

Leu Tyr Thr Asp Gly Phe Ala Phe Pro Asp Lys Lys Ala Arg Leu Tyr 
                805                 810                 815     

Pro Val Asp Trp Thr Pro Pro Ile Glu Val Gly Glu Glu Tyr Asp Leu 
            820                 825                 830         

Glu Leu Asn Asn Gly Arg Leu Leu Glu His Phe His Glu Gly Asn Met 
        835                 840                 845             

Thr Ser Arg Val Pro Gly Ile His Glu Lys Val Pro Glu Thr Phe Val 
    850                 855                 860                 

Glu Ile Ser Pro Glu Leu Ala Lys Glu Arg Gly Val Gln Asp Gly Ala 
865                 870                 875                 880 

Leu Val Arg Leu Val Ser Pro Tyr Gly Ser Ile Lys Val Arg Val Ala 
                885                 890                 895     

Val Thr Asp Arg Val Ser Gly Lys His Val Tyr Val Pro Leu Leu Ser 
            900                 905                 910         

His Ala Asp Glu Glu Ala Val Asn Arg Leu Thr Ser Ser Asp His Asp 
        915                 920                 925             

Thr Ala Thr Tyr Thr Pro Ala Tyr Lys Glu Met Arg Val Arg Met Glu 
    930                 935                 940                 

Val Ile Gln Ser Cys Gly Glu Pro Pro Ile Lys Arg Gly Asn Phe Arg 
945                 950                 955                 960 

Leu Gly Lys Pro Asn Pro Gln Pro Gly Val Asn Val Glu Gln Lys Trp 
                965                 970                 975     

Ala Arg Lys Asp Tyr Val Pro Leu Val Thr Asp Arg Ala Leu Val Lys 
            980                 985                 990         

Glu Gly 
        

<210>   861
<211>   994
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 851

<400>   861
Met Ile Asp Ile Arg Thr Glu Ala Gln Ala Glu Ala Arg Thr Val Gln 
                5                   10                  15      

Leu Glu Ile Asp Gly Lys Asp Val Thr Val Glu Arg Gly Ala Ser Val 
            20                  25                  30          

Leu Asp Ala Ile Leu Ser Thr Gly Gln Glu His Pro His Val Cys Tyr 
        35                  40                  45              

His Pro Ala Leu Gly Pro Ile Glu Thr Cys Asp Thr Cys Ile Val Glu 
    50                  55                  60                  

Ile Asp Gly Lys Leu Met Arg Ala Cys Ser Thr Pro Val Glu Asp Gly 
65                  70                  75                  80  

Met Ala Val Arg Thr Lys Ser Val Ala Ala Arg Tyr Ala Arg Lys Glu 
                85                  90                  95      

Ala Met Asp Arg Ile Leu Lys Asn His Glu Leu Tyr Cys Thr Val Cys 
            100                 105                 110         

Asp Asn Asn Asn Gly Asn Cys Val Leu His Asn Thr Val Met Gln Met 
        115                 120                 125             

Gly Val Glu His Gln Ala Tyr Pro Phe Thr Pro Lys Pro Tyr Glu Val 
    130                 135                 140                 

Asp Met Ser Asn Pro Phe Tyr Arg Tyr Asp Pro Gln Gln Cys Ile Leu 
145                 150                 155                 160 

Cys Gly Arg Cys Val Glu Ala Cys Gln Asn Leu Gln Val Ser Glu Val 
                165                 170                 175     

Leu Ser Ile Ala Trp Asp Arg Glu Val Pro Arg Val Ile Trp Asp Asn 
            180                 185                 190         

Asp Val Pro Ile Asn Glu Ser Ser Cys Val Ser Cys Gly His Cys Val 
        195                 200                 205             

Thr Val Cys Pro Thr Asn Ala Leu Met Glu Lys Ser Met Leu Gly Glu 
    210                 215                 220                 

Ala Gly Phe Leu Thr Gly Ile Glu Lys Pro Thr Leu Asp Lys Met Ile 
225                 230                 235                 240 

Asp Ile Thr Lys Lys Val Glu Pro Gly Tyr Ser Ser Ile Phe Val Val 
                245                 250                 255     

Ser Glu Ile Glu His Glu Met Arg Glu Ala Arg Ile Arg Lys Thr Lys 
            260                 265                 270         

Thr Val Cys Thr Tyr Cys Gly Val Gly Cys Ala Phe Asp Val Trp Thr 
        275                 280                 285             

Lys Asp Arg His Ile Leu Lys Val Glu Pro Gln Met Glu Ala Pro Val 
    290                 295                 300                 

Asn Gln Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp Asp Phe Val 
305                 310                 315                 320 

Asn Ser Pro Asp Arg Leu Thr Lys Pro Leu Val Arg Lys Gly Asp Arg 
                325                 330                 335     

Phe Val Glu Val Ser Trp Asp Glu Ala Leu Asp Val Ile Glu Arg Arg 
            340                 345                 350         

Ile Lys Glu Ile Gln Ala Lys His Gly Tyr Asp Ala Val Ala Phe Ile 
        355                 360                 365             

Ser Ser Ser Lys Thr Thr Asn Glu Glu Asn Tyr Leu Met Gln Lys Leu 
    370                 375                 380                 

Ala Arg Ala Val Met His Thr Asn Asn Ile Asp Asn Cys Ser Arg Tyr 
385                 390                 395                 400 

Cys Gln Ser Pro Ala Thr Glu Ala Leu Arg Arg Thr Met Gly Leu Gly 
                405                 410                 415     

Gly Asp Thr Gly Ser Ile Lys Asp Leu Glu Leu Ala Asp Leu Val Leu 
            420                 425                 430         

Ile Val Gly Ala Asn Pro Ala Glu Ala His Pro Val Leu Ser Thr Arg 
        435                 440                 445             

Leu Arg Arg Ala Gln Lys Lys Arg Gly Gln Lys His Ile Val Ala Asp 
    450                 455                 460                 

Val Arg Arg Asn Ile Met Ala Thr Arg Ala Asp Leu Phe Ile Gln Pro 
465                 470                 475                 480 

Arg Gln Gly Thr Asp Leu Val Trp Leu Ser Ala Val Thr Lys Tyr Ile 
                485                 490                 495     

Ile Asp Gln Gly Arg His Asp Glu Ala Phe Leu Arg Asp Arg Val Asn 
            500                 505                 510         

Gly Phe Asp Glu Tyr Val Gln Ser Leu Glu Lys Phe Thr Leu Asp Tyr 
        515                 520                 525             

Ala Ser Glu Ile Cys Gly Leu Arg Lys Glu Glu Leu Val Arg Val Ala 
    530                 535                 540                 

Glu Met Ile Met Glu Ala Lys Arg Val Ala Val Cys Trp Ala Met Gly 
545                 550                 555                 560 

Val Thr Gln His Arg Gly Gly Ser Asp Thr Ser Thr Ala Ile Cys Asn 
                565                 570                 575     

Leu Leu Leu Val Thr Gly Asn Val Ala Arg Pro Gly Thr Gly Ala Tyr 
            580                 585                 590         

Pro Leu Arg Gly His Asn Asn Val Gln Gly Ala Gly Asp Met Gly Cys 
        595                 600                 605             

Ala Pro Pro Phe Leu Pro Gly Tyr Glu Arg Val Asp Asn Glu Glu Gln 
    610                 615                 620                 

Arg Arg Lys Trp Glu Lys Leu Trp Gly Val Glu Leu Pro Thr Thr Pro 
625                 630                 635                 640 

Gly Leu Asn Asn His Gln Met Val Asp Ala Ile His Glu Gly Lys Leu 
                645                 650                 655     

Lys Ala Met Tyr Leu Cys Gly Glu Asp Met Ala Val Val Asp Ser Asn 
            660                 665                 670         

Ala Asn Tyr Val Glu Asp Ala Phe Arg Lys Leu Glu Phe Phe Val Val 
        675                 680                 685             

Gln Asp Val Phe Leu Ser Lys Thr Ala Gln Phe Ala Asp Val Val Leu 
    690                 695                 700                 

Pro Ala Cys Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr Asn Thr Glu 
705                 710                 715                 720 

Arg Arg Ile Gln Arg Leu Tyr Arg Val Leu Glu Pro Leu Gly Asp Ala 
                725                 730                 735     

Lys Pro Asp Trp Glu Ile Ile Gln Met Val Ala Asn Arg Phe Gly Ala 
            740                 745                 750         

His Trp Asn Tyr Thr Ser Ala Arg Glu Ile Phe Glu Glu Met Ala Ser 
        755                 760                 765             

Ala Ala Asp Leu Phe Arg Gly Ala Ser Tyr Asp Arg Leu Glu Gly Tyr 
    770                 775                 780                 

Gly Ser Leu Gln Trp Pro Val Leu Pro Asp Gly Thr Asp Thr Pro Leu 
785                 790                 795                 800 

Leu Tyr Thr Asp Gly Phe Ala Phe Pro Asp Lys Lys Ala Arg Leu Tyr 
                805                 810                 815     

Pro Val Asp Trp Thr Pro Pro Ile Glu Val Gly Glu Glu Tyr Asp Leu 
            820                 825                 830         

Glu Leu Asn Asn Gly Arg Leu Leu Glu His Phe His Glu Gly Asn Met 
        835                 840                 845             

Thr Ser Arg Val Pro Gly Ile His Glu Lys Val Pro Glu Thr Phe Val 
    850                 855                 860                 

Glu Ile Ser Pro Glu Leu Ala Lys Glu Arg Gly Val Gln Asp Gly Ala 
865                 870                 875                 880 

Leu Val Arg Leu Val Ser Pro Tyr Gly Ser Ile Lys Val Arg Val Ala 
                885                 890                 895     

Val Thr Asp Arg Val Ser Gly Lys His Val Tyr Val Pro Leu Leu Ser 
            900                 905                 910         

His Ala Asp Glu Glu Ala Val Asn Arg Leu Thr Ser Ser Asp His Asp 
        915                 920                 925             

Thr Ala Thr Tyr Thr Pro Ala Tyr Lys Glu Met Arg Val Arg Met Glu 
    930                 935                 940                 

Val Ile Gln Ser Cys Gly Glu Pro Pro Ile Lys Arg Gly Asn Phe Arg 
945                 950                 955                 960 

Leu Gly Lys Pro Asn Pro Gln Pro Gly Val Asn Val Glu Gln Lys Trp 
                965                 970                 975     

Ala Arg Lys Asp Tyr Val Pro Leu Val Thr Asp Arg Ala Leu Val Lys 
            980                 985                 990         

Glu Gly 
        

<210>   862
<211>   994
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 851

<400>   862
Met Ile Asp Ile Arg Thr Glu Ala Gln Ala Glu Ala Arg Thr Val Gln 
                5                   10                  15      

Leu Glu Ile Asp Gly Lys Glu Val Thr Val Glu Arg Gly Ala Ser Val 
            20                  25                  30          

Leu Asp Ala Ile Leu Ser Thr Gly Gln Glu His Pro His Val Cys Tyr 
        35                  40                  45              

His Pro Ala Leu Gly Pro Ile Glu Thr Cys Asp Thr Cys Ile Val Glu 
    50                  55                  60                  

Ile Asp Gly Lys Leu Met Arg Ala Cys Ser Thr Pro Ile Glu Asp Gly 
65                  70                  75                  80  

Met Ala Val Arg Thr Lys Ser Val Ala Ala Arg Tyr Ala Arg Lys Glu 
                85                  90                  95      

Ala Met Asp Arg Ile Leu Lys Asn His Glu Leu Tyr Cys Thr Val Cys 
            100                 105                 110         

Asp Asn Asn Asn Gly Asn Cys Val Leu His Asn Thr Val Met Gln Met 
        115                 120                 125             

Gly Val Glu His Gln Ala Tyr Pro Phe Thr Pro Lys Pro Tyr Glu Val 
    130                 135                 140                 

Asp Met Ser Asn Pro Phe Tyr Arg Tyr Asp Pro Gln Gln Cys Ile Leu 
145                 150                 155                 160 

Cys Gly Arg Cys Val Glu Ala Cys Gln Asn Leu Gln Val Ser Glu Val 
                165                 170                 175     

Leu Ser Ile Ala Trp Asp Arg Glu Val Pro Arg Val Ile Trp Asp Asn 
            180                 185                 190         

Asp Val Pro Ile Asn Glu Ser Ser Cys Val Ser Cys Gly His Cys Val 
        195                 200                 205             

Thr Val Cys Pro Thr Asn Ala Leu Met Glu Lys Ser Met Leu Gly Glu 
    210                 215                 220                 

Ala Gly Phe Leu Thr Gly Ile Glu Lys Pro Thr Leu Asp Lys Met Ile 
225                 230                 235                 240 

Asp Ile Thr Lys Lys Val Glu Pro Gly Tyr Ser Ser Ile Phe Val Val 
                245                 250                 255     

Ser Glu Ile Glu His Glu Met Arg Glu Ala Arg Ile Arg Lys Thr Lys 
            260                 265                 270         

Thr Val Cys Thr Tyr Cys Gly Val Gly Cys Ala Phe Asp Val Trp Thr 
        275                 280                 285             

Lys Asp Arg His Ile Leu Lys Val Glu Pro Gln Met Glu Ala Pro Val 
    290                 295                 300                 

Asn Gln Ile Ser Thr Cys Val Lys Gly Lys Phe Gly Trp Asp Phe Val 
305                 310                 315                 320 

Asn Ser Pro Asp Arg Leu Thr Lys Pro Leu Val Arg Lys Gly Asp Arg 
                325                 330                 335     

Phe Val Glu Val Ser Trp Asp Glu Ala Leu Asp Val Ile Glu Arg Arg 
            340                 345                 350         

Ile Lys Glu Ile Gln Ala Lys His Gly Tyr Asp Ala Val Ala Phe Ile 
        355                 360                 365             

Ser Ser Ser Lys Thr Thr Asn Glu Glu Asn Tyr Leu Met Gln Lys Leu 
    370                 375                 380                 

Ala Arg Ala Val Met His Thr Asn Asn Ile Asp Asn Cys Ser Arg Tyr 
385                 390                 395                 400 

Cys Gln Ser Pro Ala Thr Glu Ala Leu Arg Arg Thr Met Gly Leu Gly 
                405                 410                 415     

Gly Asp Thr Gly Ser Ile Lys Asp Leu Glu Leu Ala Asp Leu Val Leu 
            420                 425                 430         

Ile Val Gly Ala Asn Pro Ala Glu Ala His Pro Val Leu Ser Thr Arg 
        435                 440                 445             

Leu Arg Arg Ala Gln Lys Lys Arg Gly Gln Lys His Ile Val Ala Asp 
    450                 455                 460                 

Val Arg Arg Asn Ile Met Ala Thr Arg Ala Asp Leu Phe Ile Gln Pro 
465                 470                 475                 480 

Arg Gln Gly Thr Asp Leu Val Trp Leu Ser Ala Val Thr Lys Tyr Ile 
                485                 490                 495     

Ile Asp Gln Gly Arg His Asp Glu Ala Phe Leu Arg Asp Arg Val Asn 
            500                 505                 510         

Gly Phe Asp Glu Tyr Val Gln Ser Leu Glu Lys Phe Thr Leu Asp Tyr 
        515                 520                 525             

Ala Ser Glu Ile Cys Gly Leu Arg Lys Glu Glu Leu Val Arg Val Ala 
    530                 535                 540                 

Glu Met Ile Met Glu Ala Lys Arg Val Ala Val Cys Trp Ala Met Gly 
545                 550                 555                 560 

Val Thr Gln His Arg Gly Gly Ser Asp Thr Ser Thr Ala Ile Cys Asn 
                565                 570                 575     

Leu Leu Leu Val Thr Gly Asn Val Ala Arg Pro Gly Thr Gly Ala Tyr 
            580                 585                 590         

Pro Leu Arg Gly His Asn Asn Val Gln Gly Ala Gly Asp Met Gly Cys 
        595                 600                 605             

Ala Pro Pro Phe Leu Pro Gly Tyr Glu Arg Val Asp Asn Glu Glu Gln 
    610                 615                 620                 

Arg Arg Lys Trp Glu Lys Leu Trp Gly Val Glu Leu Pro Thr Thr Pro 
625                 630                 635                 640 

Gly Leu Asn Asn His Gln Met Val Asp Ala Ile His Glu Gly Lys Leu 
                645                 650                 655     

Lys Ala Met Tyr Leu Cys Gly Glu Asp Met Ala Val Val Asp Ser Asn 
            660                 665                 670         

Ala Asn Tyr Val Glu Asp Ala Phe Arg Lys Leu Glu Phe Phe Val Val 
        675                 680                 685             

Gln Asp Val Phe Leu Ser Lys Thr Ala Gln Phe Ala Asp Val Val Leu 
    690                 695                 700                 

Pro Ala Cys Pro Ser Leu Glu Lys Glu Gly Thr Phe Thr Asn Thr Glu 
705                 710                 715                 720 

Arg Arg Ile Gln Arg Leu Tyr Arg Val Leu Glu Pro Leu Gly Asp Ala 
                725                 730                 735     

Lys Pro Asp Trp Glu Ile Ile Gln Met Val Ala Asn Arg Phe Gly Ala 
            740                 745                 750         

His Trp Asn Tyr Thr Ser Ala Arg Glu Ile Phe Glu Glu Met Ala Ser 
        755                 760                 765             

Ala Ala Asp Leu Phe Arg Gly Ala Ser Tyr Asp Arg Leu Glu Gly Tyr 
    770                 775                 780                 

Gly Ser Leu Gln Trp Pro Val Leu Pro Asp Gly Thr Asp Thr Pro Leu 
785                 790                 795                 800 

Leu Tyr Thr Asp Gly Phe Ala Phe Pro Asp Lys Lys Ala Arg Leu Tyr 
                805                 810                 815     

Pro Val Asp Trp Thr Pro Pro Ile Glu Val Gly Glu Glu Tyr Asp Leu 
            820                 825                 830         

Glu Leu Asn Asn Gly Arg Leu Leu Glu His Phe His Glu Gly Asn Met 
        835                 840                 845             

Thr Ser Arg Val Pro Gly Ile His Glu Lys Val Pro Glu Thr Phe Val 
    850                 855                 860                 

Glu Ile Ser Pro Glu Leu Ala Lys Glu Arg Gly Val Gln Asp Gly Ala 
865                 870                 875                 880 

Leu Val Arg Leu Val Ser Pro Tyr Gly Ser Ile Lys Val Arg Val Ala 
                885                 890                 895     

Val Thr Asp Arg Val Ser Gly Lys His Val Tyr Val Pro Leu Leu Ser 
            900                 905                 910         

His Ala Asp Glu Glu Ala Val Asn Arg Leu Thr Ser Ser Asp His Asp 
        915                 920                 925             

Thr Ala Thr Tyr Thr Pro Ala Tyr Lys Glu Met Arg Val Arg Met Glu 
    930                 935                 940                 

Val Ile Gln Ser Cys Gly Glu Pro Pro Ile Lys Arg Gly Asn Phe Arg 
945                 950                 955                 960 

Leu Gly Lys Pro Asn Pro Gln Pro Gly Val Asn Val Glu Gln Lys Trp 
                965                 970                 975     

Ala Arg Lys Asp Tyr Val Pro Leu Val Thr Asp Arg Ala Leu Val Lys 
            980                 985                 990         

Glu Gly 
        

<210>   863
<211>   2985
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 852

<400>   863
atgatcgata tcaggaccga agcacaggcc gaggcgcgga ccgtgcaact cgagatcgac       60

ggcaaggaag tcaccgtgga acgaggtgcg tcggtgctcg acgccattct gtccacgggc      120

caggaacatc cgcacgtctg ttatcatccg gcgctcggcc ccattgaaac gtgcgacacc      180

tgcattgtcg agatcgacgg caagctgatg cgcgcgtgtt ccacacctgt cgaggacggg      240

atggcggtcc ggaccaagtc cgtggccgcg cggtatgccc gcaaagaggc gatggaccgc      300

attctgaaga accacgagct gtactgcacc gtgtgcgaca acaacaacgg caactgcgtg      360

ctgcacaaca ccgtgatgca gatgggcgtg gaacatcagg cgtatccgtt cacgcccaag      420

ccgtacgagg tcgacatgtc gaacccgttt tatcggtacg atccgcagca gtgcatcctt      480

tgcggccgct gcgtcgaggc gtgccaaaac ctgcaggtga gcgaggttct ctccatcgcg      540

tgggatcgcg aggtgccgcg ggtcatctgg gacaacgacg tgcccatcaa cgagtcgtcg      600

tgtgtgtcgt gtggccactg cgtgacggtc tgtccgacca acgcgctcat ggaaaaatcc      660

atgcttgggg aagcgggctt cctcacgggc atcgaaaagc cgaccctgga taagatgatc      720

gacatcacca agaaggtcga gcccggttac tcgtccatct ttgtcgtctc ggagattgag      780

cacgagatgc gcgaagcgcg cattcggaag acgaagacgg tctgcacgta ttgcggcgtg      840

ggctgcgcgt tcgacgtgtg gacgaaggat cggcacattt taaaggtcga gccgcagatg      900

gaggcgccgg tcaaccagat ctccacgtgc gtcaagggca agttcggctg ggactttgtg      960

aacagcccgg atcgcctgac caagcctctg gtgcgcaagg gcgatcggtt cgtggaagtg     1020

agctgggacg aggcgctcga cgtgatcgaa cggcgcatca aggagatcca ggcgaagcac     1080

gggtacgacg cggtggcgtt catctcgtcg tccaagacga ccaacgaaga aaactacctg     1140

atgcagaagc tggcgcgcgc cgtcatgcac acgaacaaca tcgacaactg ctcgcgttac     1200

tgccagtctc ctgcgaccga ggcgctgcgg cggaccatgg ggctcggcgg cgacaccgga     1260

tctatcaagg atctggagct ggccgatctc gtcctcatcg tcggcgcgaa ccctgccgag     1320

gcgcatcccg tgttgtcgac gcgcctgcgc cgggcgcaga agaagcgcgg ccagaagcac     1380

atcgtggccg acgtgcggcg caacatcatg gcgacacgcg ccgatctctt catccagccg     1440

cgccagggca cggacttggt ctggttgtcc gcggtgacga agtacatcat cgatcagggc     1500

cggcacgacg aggcattcct gcgggatcgc gtgaatggct ttgacgaata cgtgcagtcg     1560

ctcgagaagt tcacgctgga ctacgcgagc gagatctgcg gcctcaaaaa agaggagctc     1620

gtccgcgtgg ccgagatgat catggaggca aagcgcgtcg cggtctgctg ggccatgggc     1680

gtgacgcagc accggggtgg cagtgacacg tcgaccgcca tctgcaactt gcttttggtg     1740

accgggaacg tggcgcggcc gggcacgggt gcgtatccgc tgcgcggtca caacaacgtg     1800

cagggagccg gtgacatggg ctgcgcgcct ccgttcctgc cgggctacga gcgcgtggac     1860

aacgaagagc agcggcgcaa gtgggagaag ctctggggcg tcgaactgcc gaccacgcct     1920

gggctcaaca atcatcagat ggtggatgcc attcacgaag gcaagctgaa ggcgatgtac     1980

ctctgcgggg aggacatggc ggtggtggac tccaacgcca actacgtgga ggacgccttc     2040

cggaaactcg agttcttcgt ggtccaggac gtcttcctgt ccaagaccgc gcagttcgcg     2100

gacgtggtcc ttccggcctg cccgagcctt gagaaggagg gcacgttcac gaacaccgag     2160

cggcgcatcc agcgcttgta tcgggtgctt gaaccgctgg gagacgcgaa gccggactgg     2220

gagatcattc aaatggtcgc caaccggttt ggcgcccatt ggaactacac atctgcgcgc     2280

gagattttcg aggagatggc gagtgcggcc gatctgttcc ggggggcgtc gtacgaccgc     2340

ctcgagggct acgggagcct gcagtggccc gtgcttcccg acggcaccga cacgccgctc     2400

ctgtacacgg acggcttcgc attccccgac aagaaggcgc ggctctatcc ggtcgactgg     2460

acgccgccca tcgaagtcgg ggaggaatac gatctagagt tgaacaacgg gcgcttgctc     2520

gagcacttcc acgagggcaa catgacgagc cgcgtgcccg gtatccacga aaaagtgccg     2580

gaaaccttcg tcgagatctc gccggagctc gcgaaggagc gcggtgtcca ggacggcgcg     2640

ctggtgcgcc tcgtctcgcc gtacggcagc atcaaggtgc gcgtggccgt gacggatcgc     2700

gtgtccggga aacacgtgta cgttccgctc ttgtcccatg cggacgagga ggcggtcaac     2760

cgcctcacgt cgagcgatca cgacaccgcc acctacacgc ctgcctataa ggaaatgcgc     2820

gtgcgcatgg aggtcatcca atcgtgtggc gagccgccca tcaagcgcgg gaacttccgc     2880

ctgggcaagc cgaacccgca gcccggtgtg aacgtcgagc aaaagtgggc gcgcaaggac     2940

tacgtgccgc tggtgacgga tcgcgcgctt gtgaaggagg gttga                     2985


<210>   864
<211>   2985
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 852

<400>   864
atgatcgata tcaggaccga agcacaggcc gaggcgcgga ccgtgcaact cgagatcgac       60

ggcaaggaag tcaccgtgga acgaggtgcg tcggtgctcg acgccattct gtccacgggc      120

caggaacatc cgcacgtctg ttatcatccg gcgctcggcc ccattgaaac gtgcgacacc      180

tgcattgtcg agatcgacgg caagctgatg cgcgcgtgtt ccacacctgt cgaggacggg      240

atggcggtcc ggaccaagtc cgtggccgcg cggtatgccc gcaaagaggc gatggaccgc      300

attctgaaga accacgagct gtactgcacc gtgtgcgaca acaacaacgg caactgcgtg      360

ctgcacaaca ccgtgatgca gatgggcgtg gaacatcagg cgtatccgtt cacgcccaag      420

ccgtacgagg tcgacatgtc gaacccgttt tatcggtacg atccgcagca gtgcatcctt      480

tgcggccgct gcgtcgaggc gtgccaaaac ctgcaggtga gcgaggttct ctccatcgcg      540

tgggatcgcg aggtgccgcg ggtcatctgg gacaacgacg tgcccatcaa cgagtcgtcg      600

tgtgtgtcgt gtggccactg cgtgacggtc tgtccgacca acgcgctcat ggaaaaatcc      660

atgcttgggg aagcgggctt cctcacgggc atcgaaaagc cgaccctgga taagatgatc      720

gacatcacca agaaggtcga gcccggttac tcgtccatct ttgtcgtctc ggagattgag      780

cacgagatgc gcgaagcgcg cattcggaag acgaagacgg tctgcacgta ttgcggcgtg      840

ggctgcgcgt tcgacgtgtg gacgaaggat cggcacattt taaaggtcga gccgcagatg      900

gaggcgccgg tcaaccagat ctccacgtgc gtcaagggca agttcggctg ggactttgtg      960

aacagcccgg atcgcctgac caagcctctg gtgcgcaagg gcgatcggtt cgtggaagtg     1020

agctgggacg aggcgctcga cgtgatcgaa cggcgcatca aggagatcca ggcgaagcac     1080

gggtacgacg cggtggcgtt catctcgtcg tccaagacga ccaacgaaga aaactacctg     1140

atgcagaagc tggcgcgcgc cgtcatgcac acgaacaaca tcgacaactg ctcgcgttac     1200

tgccagtctc ctgcgaccga ggcgctgcgg cggaccatgg ggctcggcgg cgacaccgga     1260

tctatcaagg atctggagct ggccgatctc gtcctcatcg tcggcgcgaa ccctgccgag     1320

gcgcatcccg tgttgtcgac gcgcctgcgc cgggcgcaga agaagcgcgg ccagaagcac     1380

atcgtggccg acgtgcggcg caacatcatg gcgacacgcg ccgatctctt catccagccg     1440

cgccagggca cggacttggt ctggttgtcc gcggtgacga agtacatcat cgatcagggc     1500

cggcacgacg aggcattcct gcgggatcgc gtgaatggct ttgacgaata cgtgcagtcg     1560

ctcgagaagt tcacgctgga ctacgcgagc gagatctgcg gcctccgcaa agaggagctc     1620

gtccgcgtgg ccgagatgat catggaggca aagcgcgtcg cggtctgctg ggccatgggc     1680

gtgacgcagc accggggtgg cagtgacacg tcgaccgcca tctgcaactt gcttttggtg     1740

accgggaacg tggcgcggcc gggcacgggt gcgtatccgc tgcgcggtca caacaacgtg     1800

cagggagccg gtgacatggg ctgcgcgcct ccgttcctgc cgggctacga gcgcgtggac     1860

aacgaagagc agcggcgcaa gtgggagaag ctctggggcg tcgaactgcc gaccacgcct     1920

gggctcaaca atcatcagat ggtggatgcc attcacgaag gcaagctgaa ggcgatgtac     1980

ctctgcgggg aggacatggc ggtggtggac tccaacgcca actacgtgga ggacgccttc     2040

cggaaactcg agttcttcgt ggtccaggac gtcttcctgt ccaagaccgc gcagttcgcg     2100

gacgtggtcc ttccggcctg cccgagcctt gagaaggagg gcacgttcac gaacaccgag     2160

cggcgcatcc agcgcttgta tcgggtgctt gaaccgctgg gagacgcgaa gccggactgg     2220

gagatcattc aaatggtcgc caaccggttt ggcgcccatt ggaactacac atctgcgcgc     2280

gagattttcg aggagatggc gagtgcggcc gatctgttcc ggggggcgtc gtacgaccgc     2340

ctcgagggct acgggagcct gcagtggccc gtgcttcccg acggcaccga cacgccgctc     2400

ctgtacacgg acggcttcgc attccccgac aagaaggcgc ggctctatcc ggtcgactgg     2460

acgccgccca tcgaagtcgg ggaggaatac gatctagagt tgaacaacgg gcgcttgctc     2520

gagcacttcc acgagggcaa catgacgagc cgcgtgcccg gtatccacga aaaagtgccg     2580

gaaaccttcg tcgagatctc gccggagctc gcgaaggagc gcggtgtcca ggacggcgcg     2640

ctggtgcgcc tcgtctcgcc gtacggcagc atcaaggtgc gcgtggccgt gacggatcgc     2700

gtgtccggga aacacgtgta cgttccgctc ttgtcccatg cggacgagga ggcggtcaac     2760

cgcctcacgt cgagcgatca cgacaccgcc acctacacgc ctgcctataa ggaaatgcgc     2820

gtgcgcatgg aggtcatcca atcgtgtggc gagccgccca tcaagcgcgg gaacttccgc     2880

ctgggcaagc cgaacccgca gcccggtgtg aacgtcgagc aaaagtgggc gcgcaaggac     2940

tacgtgccgc tggtgacgga tcgcgcgctt gtgaaggatg gttga                     2985


<210>   865
<211>   2985
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 852

<400>   865
atgatcgata tcaggaccga agcacaggcc gaggcgcgga ccgtgcaact cgagatcgac       60

ggcaaggaag tcaccgtgga acgaggtgcg tcggtgctcg acgccattct gtccacgggc      120

caggaacatc cgcacgtctg ttatcatccg gcgctcggcc ccattgaaac gtgcgacacc      180

tgcattgtcg agatcgacgg caagctgatg cgcgcgtgtt ccacacctgt cgaggacggg      240

atggcggtcc ggaccaagtc cgtggccgcg cggtatgccc gcaaagaggc gatggaccgc      300

attctgaaga accacgagct gtactgcacc gtgtgcgaca acaacaacgg caactgcgtg      360

ctgcacaaca ccgtgatgca gatgggcgtg gaacatcagg cgtatccgtt cacgcccaag      420

ccgtacgagg tcgacatgtc gaacccgttt tatcggtacg atccgcagca gtgcatcctt      480

tgcggccgct gcgtcgaggc gtgccaaaac ctgcaggtga gcgaggttct ctccatcgcg      540

tgggatcgcg aggtgccgcg ggtcatctgg gacaacgacg tgcccatcaa cgagtcgtcg      600

tgtgtgtcgt gtggccactg cgtgacggtc tgtccgacca acgcgctcat ggaaaaatcc      660

atgcttgggg aagcgggctt cctcacgggc atcgaaaagc cgaccctgga taagatgatc      720

gacatcacca agaaggtcga gcccggttac tcgtccatct ttgtcgtctc ggagattgag      780

cacgagatgc gcgaagcgcg cattcggaag acgaagacgg tctgcacgta ttgcggcgtg      840

ggctgcgcgt tcgacgtgtg gacgaaggat cggcacattt taaaggtcga gccgcagatg      900

gaggcgccgg tcaaccagat ctccacgtgc gtcaagggca agttcggctg ggactttgtg      960

aacagcccgg atcgcctgac caagcctctg gtgcgcaagg gcgatcggtt cattgaagtg     1020

agctgggacg aggcgctcga cgtgatcgaa cggcgcatca aggagatcca ggcgaagcac     1080

gggtacgacg cggtggcgtt catctcgtcg tccaagacga ccaacgaaga aaactacctg     1140

atgcagaagc tggcgcgcgc cgtcatgcac acgaacaaca tcgacaactg ctcgcgttac     1200

tgccagtctc ctgcgaccga ggcgctgcgg cggaccatgg ggctcggcgg cgacaccgga     1260

tctatcaagg atctggagct ggccgatctc gtcctcatcg tcggcgcgaa ccctgccgag     1320

gcgcatcccg tgttgtcgac gcgcctgcgc cgggcgcaga agaagcgcgg ccagaagcac     1380

atcgtggccg acgtgcggcg caacatcatg gcgacacgcg ccgatctctt catccagccg     1440

cgccagggca cggacttggt ctggttgtcc gcggtgacga agtacatcat cgatcagggc     1500

cggcacgacg aggcattcct gcgggatcgc gtgaatggct ttgacgaata cgtgcagtcg     1560

ctcgagaagt tcacgctgga ctacgcgagc gagatctgcg gcctccgcaa agaggagctc     1620

gtccgcgtgg ccgagatgat catggaggca aagcgcgtcg cggtctgctg ggccatgggc     1680

gtgacgcagc accggggtgg cagtgacacg tcgaccgcca tctgcaactt gcttttggtg     1740

accgggaacg tggcgcggcc gggcacgggt gcgtatccgc tgcgcggtca caacaacgtg     1800

cagggagccg gtgacatggg ctgcgcgcct ccgttcctgc cgggctacga gcgcgtggac     1860

aacgaagagc agcggcgcaa gtgggagaag ctctggggcg tcgaactgcc gaccacgcct     1920

gggctcaaca atcatcagat ggtggatgcc attcacgaag gcaagctgaa ggcgatgtac     1980

ctctgcgggg aggacatggc ggtggtggac tccaacgcca actacgtgga ggacgccttc     2040

cggaaactcg agttcttcgt ggtccaggac gtcttcctgt ccaagaccgc gcagttcgcg     2100

gacgtggtcc ttccggcctg cccgagcctt gagaaggagg gcacgttcac gaacaccgag     2160

cggcgcatcc agcgcttgta tcgggtgctt gaaccgctgg gagacgcgaa gccggactgg     2220

gagatcattc aaatggtcgc caaccggttt ggcgcccatt ggaactacac atctgcgcgc     2280

gagattttcg aggagatggc gagtgcggcc gatctgttcc ggggggcgtc gtacgaccgc     2340

ctcgagggct acgggagcct gcagtggccc gtgcttcccg acggcaccga cacgccgctc     2400

ctgtacacgg acggcttcgc attccccgac aagaaggcgc ggctctatcc ggtcgactgg     2460

acgccgccca tcgaagtcgg ggaggaatac gatctagagt tgaacaacgg gcgcttgctc     2520

gagcacttcc acgagggcaa catgacgagc cgcgtgcccg gtatccacga aaaagtgccg     2580

gaaaccttcg tcgagatctc gccggagctc gcgaaggagc gcggtgtcca ggacggcgcg     2640

ctggtgcgcc tcgtctcgcc gtacggcagc atcaaggtgc gcgtggccgt gacggatcgc     2700

gtgtccggga aacacgtgta cgttccgctc ttgtcccatg cggacgagga ggcggtcaac     2760

cgcctcacgt cgagcgatca cgacaccgcc acctacacgc ctgcctataa ggaaatgcgc     2820

gtgcgcatgg aggtcatcca atcgtgtggc gagccgccca tcaagcgcgg gaacttccgc     2880

ctgggcaagc cgaacccgca gcccggtgtg aacgtcgagc aaaagtgggc gcgcaaggac     2940

tacgtgccgc tggtgacgga tcgcgcgctt gtgaaggagg gttga                     2985


<210>   866
<211>   2985
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 852

<400>   866
atgatcgata tcaggaccga agcacaggcc gaggcgcgga ccgtgcaact cgagatcgac       60

ggcaaggatg tcaccgtgga acgaggtgcg tcggtgctcg acgccattct gtccacgggc      120

caggaacatc cgcacgtctg ttatcatccg gcgctcggcc ccattgaaac gtgcgacacc      180

tgcattgtcg agatcgacgg caagctgatg cgcgcgtgtt ccacacctgt cgaggacggg      240

atggcggtcc ggaccaagtc cgtggccgcg cggtatgccc gcaaagaggc gatggaccgc      300

attctgaaga accacgagct gtactgcacc gtgtgcgaca acaacaacgg caactgcgtg      360

ctgcacaaca ccgtgatgca gatgggcgtg gaacatcagg cgtatccgtt cacgcccaag      420

ccgtacgagg tcgacatgtc gaacccgttt tatcggtacg atccgcagca gtgcatcctt      480

tgcggccgct gcgtcgaggc gtgccaaaac ctgcaggtga gcgaggttct ctccatcgcg      540

tgggatcgcg aggtgccgcg ggtcatctgg gacaacgacg tgcccatcaa cgagtcgtcg      600

tgtgtgtcgt gtggccactg cgtgacggtc tgtccgacca acgcgctcat ggaaaaatcc      660

atgcttgggg aagcgggctt cctcacgggc atcgaaaagc cgaccctgga taagatgatc      720

gacatcacca agaaggtcga gcccggttac tcgtccatct ttgtcgtctc ggagattgag      780

cacgagatgc gcgaagcgcg cattcggaag acgaagacgg tctgcacgta ttgcggcgtg      840

ggctgcgcgt tcgacgtgtg gacgaaggat cggcacattt taaaggtcga gccgcagatg      900

gaggcgccgg tcaaccagat ctccacgtgc gtcaagggca agttcggctg ggactttgtg      960

aacagcccgg atcgcctgac caagcctctg gtgcgcaagg gcgatcggtt cgtggaagtg     1020

agctgggacg aggcgctcga cgtgatcgaa cggcgcatca aggagatcca ggcgaagcac     1080

gggtacgacg cggtggcgtt catctcgtcg tccaagacga ccaacgaaga aaactacctg     1140

atgcagaagc tggcgcgcgc cgtcatgcac acgaacaaca tcgacaactg ctcgcgttac     1200

tgccagtctc ctgcgaccga ggcgctgcgg cggaccatgg ggctcggcgg cgacaccgga     1260

tctatcaagg atctggagct ggccgatctc gtcctcatcg tcggcgcgaa ccctgccgag     1320

gcgcatcccg tgttgtcgac gcgcctgcgc cgggcgcaga agaagcgcgg ccagaagcac     1380

atcgtggccg acgtgcggcg caacatcatg gcgacacgcg ccgatctctt catccagccg     1440

cgccagggca cggacttggt ctggttgtcc gcggtgacga agtacatcat cgatcagggc     1500

cggcacgacg aggcattcct gcgggatcgc gtgaatggct ttgacgaata cgtgcagtcg     1560

ctcgagaagt tcacgctgga ctacgcgagc gagatctgcg gcctccgcaa agaggagctc     1620

gtccgcgtgg ccgagatgat catggaggca aagcgcgtcg cggtctgctg ggccatgggc     1680

gtgacgcagc accggggtgg cagtgacacg tcgaccgcca tctgcaactt gcttttggtg     1740

accgggaacg tggcgcggcc gggcacgggt gcgtatccgc tgcgcggtca caacaacgtg     1800

cagggagccg gtgacatggg ctgcgcgcct ccgttcctgc cgggctacga gcgcgtggac     1860

aacgaagagc agcggcgcaa gtgggagaag ctctggggcg tcgaactgcc gaccacgcct     1920

gggctcaaca atcatcagat ggtggatgcc attcacgaag gcaagctgaa ggcgatgtac     1980

ctctgcgggg aggacatggc ggtggtggac tccaacgcca actacgtgga ggacgccttc     2040

cggaaactcg agttcttcgt ggtccaggac gtcttcctgt ccaagaccgc gcagttcgcg     2100

gacgtggtcc ttccggcctg cccgagcctt gagaaggagg gcacgttcac gaacaccgag     2160

cggcgcatcc agcgcttgta tcgggtgctt gaaccgctgg gagacgcgaa gccggactgg     2220

gagatcattc aaatggtcgc caaccggttt ggcgcccatt ggaactacac atctgcgcgc     2280

gagattttcg aggagatggc gagtgcggcc gatctgttcc ggggggcgtc gtacgaccgc     2340

ctcgagggct acgggagcct gcagtggccc gtgcttcccg acggcaccga cacgccgctc     2400

ctgtacacgg acggcttcgc attccccgac aagaaggcgc ggctctatcc ggtcgactgg     2460

acgccgccca tcgaagtcgg ggaggaatac gatctagagt tgaacaacgg gcgcttgctc     2520

gagcacttcc acgagggcaa catgacgagc cgcgtgcccg gtatccacga aaaagtgccg     2580

gaaaccttcg tcgagatctc gccggagctc gcgaaggagc gcggtgtcca ggacggcgcg     2640

ctggtgcgcc tcgtctcgcc gtacggcagc atcaaggtgc gcgtggccgt gacggatcgc     2700

gtgtccggga aacacgtgta cgttccgctc ttgtcccatg cggacgagga ggcggtcaac     2760

cgcctcacgt cgagcgatca cgacaccgcc acctacacgc ctgcctataa ggaaatgcgc     2820

gtgcgcatgg aggtcatcca atcgtgtggc gagccgccca tcaagcgcgg gaacttccgc     2880

ctgggcaagc cgaacccgca gcccggtgtg aacgtcgagc aaaagtgggc gcgcaaggac     2940

tacgtgccgc tggtgacgga tcgcgcgctt gtgaaggagg gttga                     2985


<210>   867
<211>   2985
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 852

<400>   867
atgatcgata tcaggaccga agcacaggcc gaggcgcgga ccgtgcaact cgagatcgac       60

ggcaaggaag tcaccgtgga acgaggtgcg tcggtgctcg acgccattct gtccacgggc      120

caggaacatc cgcacgtctg ttatcatccg gcgctcggcc ccattgaaac gtgcgacacc      180

tgcattgtcg agatcgacgg caagctgatg cgcgcgtgtt ccacacctat tgaggacggg      240

atggcggtcc ggaccaagtc cgtggccgcg cggtatgccc gcaaagaggc gatggaccgc      300

attctgaaga accacgagct gtactgcacc gtgtgcgaca acaacaacgg caactgcgtg      360

ctgcacaaca ccgtgatgca gatgggcgtg gaacatcagg cgtatccgtt cacgcccaag      420

ccgtacgagg tcgacatgtc gaacccgttt tatcggtacg atccgcagca gtgcatcctt      480

tgcggccgct gcgtcgaggc gtgccaaaac ctgcaggtga gcgaggttct ctccatcgcg      540

tgggatcgcg aggtgccgcg ggtcatctgg gacaacgacg tgcccatcaa cgagtcgtcg      600

tgtgtgtcgt gtggccactg cgtgacggtc tgtccgacca acgcgctcat ggaaaaatcc      660

atgcttgggg aagcgggctt cctcacgggc atcgaaaagc cgaccctgga taagatgatc      720

gacatcacca agaaggtcga gcccggttac tcgtccatct ttgtcgtctc ggagattgag      780

cacgagatgc gcgaagcgcg cattcggaag acgaagacgg tctgcacgta ttgcggcgtg      840

ggctgcgcgt tcgacgtgtg gacgaaggat cggcacattt taaaggtcga gccgcagatg      900

gaggcgccgg tcaaccagat ctccacgtgc gtcaagggca agttcggctg ggactttgtg      960

aacagcccgg atcgcctgac caagcctctg gtgcgcaagg gcgatcggtt cgtggaagtg     1020

agctgggacg aggcgctcga cgtgatcgaa cggcgcatca aggagatcca ggcgaagcac     1080

gggtacgacg cggtggcgtt catctcgtcg tccaagacga ccaacgaaga aaactacctg     1140

atgcagaagc tggcgcgcgc cgtcatgcac acgaacaaca tcgacaactg ctcgcgttac     1200

tgccagtctc ctgcgaccga ggcgctgcgg cggaccatgg ggctcggcgg cgacaccgga     1260

tctatcaagg atctggagct ggccgatctc gtcctcatcg tcggcgcgaa ccctgccgag     1320

gcgcatcccg tgttgtcgac gcgcctgcgc cgggcgcaga agaagcgcgg ccagaagcac     1380

atcgtggccg acgtgcggcg caacatcatg gcgacacgcg ccgatctctt catccagccg     1440

cgccagggca cggacttggt ctggttgtcc gcggtgacga agtacatcat cgatcagggc     1500

cggcacgacg aggcattcct gcgggatcgc gtgaatggct ttgacgaata cgtgcagtcg     1560

ctcgagaagt tcacgctgga ctacgcgagc gagatctgcg gcctccgcaa agaggagctc     1620

gtccgcgtgg ccgagatgat catggaggca aagcgcgtcg cggtctgctg ggccatgggc     1680

gtgacgcagc accggggtgg cagtgacacg tcgaccgcca tctgcaactt gcttttggtg     1740

accgggaacg tggcgcggcc gggcacgggt gcgtatccgc tgcgcggtca caacaacgtg     1800

cagggagccg gtgacatggg ctgcgcgcct ccgttcctgc cgggctacga gcgcgtggac     1860

aacgaagagc agcggcgcaa gtgggagaag ctctggggcg tcgaactgcc gaccacgcct     1920

gggctcaaca atcatcagat ggtggatgcc attcacgaag gcaagctgaa ggcgatgtac     1980

ctctgcgggg aggacatggc ggtggtggac tccaacgcca actacgtgga ggacgccttc     2040

cggaaactcg agttcttcgt ggtccaggac gtcttcctgt ccaagaccgc gcagttcgcg     2100

gacgtggtcc ttccggcctg cccgagcctt gagaaggagg gcacgttcac gaacaccgag     2160

cggcgcatcc agcgcttgta tcgggtgctt gaaccgctgg gagacgcgaa gccggactgg     2220

gagatcattc aaatggtcgc caaccggttt ggcgcccatt ggaactacac atctgcgcgc     2280

gagattttcg aggagatggc gagtgcggcc gatctgttcc ggggggcgtc gtacgaccgc     2340

ctcgagggct acgggagcct gcagtggccc gtgcttcccg acggcaccga cacgccgctc     2400

ctgtacacgg acggcttcgc attccccgac aagaaggcgc ggctctatcc ggtcgactgg     2460

acgccgccca tcgaagtcgg ggaggaatac gatctagagt tgaacaacgg gcgcttgctc     2520

gagcacttcc acgagggcaa catgacgagc cgcgtgcccg gtatccacga aaaagtgccg     2580

gaaaccttcg tcgagatctc gccggagctc gcgaaggagc gcggtgtcca ggacggcgcg     2640

ctggtgcgcc tcgtctcgcc gtacggcagc atcaaggtgc gcgtggccgt gacggatcgc     2700

gtgtccggga aacacgtgta cgttccgctc ttgtcccatg cggacgagga ggcggtcaac     2760

cgcctcacgt cgagcgatca cgacaccgcc acctacacgc ctgcctataa ggaaatgcgc     2820

gtgcgcatgg aggtcatcca atcgtgtggc gagccgccca tcaagcgcgg gaacttccgc     2880

ctgggcaagc cgaacccgca gcccggtgtg aacgtcgagc aaaagtgggc gcgcaaggac     2940

tacgtgccgc tggtgacgga tcgcgcgctt gtgaaggagg gttga                     2985


<210>   868
<211>   529
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   868
Met Ser Tyr Val Tyr Leu Leu Asp Thr Thr Leu Arg Asp Gly Thr Gln 
                5                   10                  15      

Gly Glu Gly Val Ser Leu Thr Val Ala Asp Lys Leu Lys Ile Ala Glu 
            20                  25                  30          

Lys Leu Asp Asp Leu Gly Val Ala Tyr Ile Glu Gly Gly Phe Pro Gly 
        35                  40                  45              

Ala Asn Pro Lys Asp Glu Glu Phe Phe Arg Ala Ala Lys Ser Leu His 
    50                  55                  60                  

Leu Lys His Ala Lys Leu Thr Ala Phe Gly Ser Thr Arg Arg Pro Gly 
65                  70                  75                  80  

Val Arg Val Glu Asp Asp Ala Ser Val Arg Ala Val Leu Asp Ala Ser 
                85                  90                  95      

Thr Pro Val Val Ala Ile Val Gly Lys Ala Trp Asp Phe His Val Thr 
            100                 105                 110         

Glu Ala Leu Arg Ile Asp Leu Asp Glu Asn Leu Ala Met Ile Arg Asp 
        115                 120                 125             

Thr Val Gln Tyr Leu Lys Gln His Gly Arg Glu Val Ile Phe Asp Ala 
    130                 135                 140                 

Glu His Phe Phe Asp Gly Phe Lys Arg Asn Arg Ala Tyr Ala Leu Ala 
145                 150                 155                 160 

Thr Val Arg Ala Ala Trp Glu Ala Gly Val Asp Trp Val Ala Leu Cys 
                165                 170                 175     

Asp Thr Asn Gly Gly Ser Met Pro His Glu Ile His Glu Met Val Thr 
            180                 185                 190         

Gln Val Ile Gln Glu Val Pro Val Gln Val Gly Ile His Thr His Asn 
        195                 200                 205             

Asp Cys Glu Leu Ala Val Ala Asn Ser Leu Ala Ala Val Gln Ala Gly 
    210                 215                 220                 

Ala Arg Met Val His Gly Thr Ile Asn Gly Ile Gly Glu Arg Cys Gly 
225                 230                 235                 240 

Asn Ala Asn Leu Ala Ser Ile Ile Pro Asn Leu Glu Leu Lys Leu Gly 
                245                 250                 255     

Tyr Pro Cys Leu Pro Ser Arg Asp His Leu Arg Leu Leu Thr Pro Val 
            260                 265                 270         

Ala Arg Phe Val Gly Glu Val Cys Asn Leu Val Ala His Ser Tyr Gln 
        275                 280                 285             

Pro Phe Val Gly His Ser Ala Phe Ala His Lys Gly Gly Ile His Val 
    290                 295                 300                 

Ser Ala Ile Gln Arg Asp Pro Glu Thr Tyr Glu His Ile Pro Pro Glu 
305                 310                 315                 320 

Leu Val Gly Asn Glu Arg Arg Val Leu Leu Ser Glu Leu Ser Gly Val 
                325                 330                 335     

Ser Asn Val Leu Ala Gln Ala Gln Ala Phe Gly Ile Pro Thr Glu Gly 
            340                 345                 350         

Arg Glu Thr Glu Leu Arg Arg Leu Leu Glu Arg Ile Lys Gln Met Glu 
        355                 360                 365             

His Met Gly Tyr Gln Phe Glu Gly Ala Glu Ala Ser Gln Glu Leu Leu 
    370                 375                 380                 

Phe Arg Arg Val Leu Asn Asp Phe Thr Pro Pro Phe Lys Val Leu Ala 
385                 390                 395                 400 

Val Arg Val Asp Thr Asp Val Gln Arg Gln Gly Glu Ala Thr Ser Gln 
                405                 410                 415     

Ala Ile Ile Lys Leu Glu Val Asp Gly Glu Ile Val His Thr Val Ser 
            420                 425                 430         

Glu Gly Asn Gly Pro Val Asn Ala Leu Asp Ala Val Leu Arg Lys Ala 
        435                 440                 445             

Leu Ala Pro His Arg Pro Glu Ile Arg Arg Met His Leu Thr Asp Tyr 
    450                 455                 460                 

Lys Val Arg Val Leu Asp Glu Lys Asp Ala Thr Ala Ala Arg Val Arg 
465                 470                 475                 480 

Val Leu Ile Glu Ser Thr Asp Gly Glu His Val Trp Arg Thr Val Gly 
                485                 490                 495     

Val Ser Glu Asn Val Ile Ala Ala Ser Trp Glu Ala Leu Val Asp Ser 
            500                 505                 510         

Ile Gln Tyr Tyr Leu Ala Leu Val Val Pro Ser Gln Ala Leu Val Glu 
        515                 520                 525             

Ala 
    

<210>   869
<211>   1590
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   869
atgagctacg tgtatttgct cgataccaca ttgcgggatg gcacgcaggg cgagggggtc       60

agcctcaccg tcgccgacaa actcaagatt gcagaaaagt tggacgatct cggcgtcgcc      120

tacatcgaag gcggctttcc gggcgcgaat ccgaaggatg aggagttttt ccgcgccgcg      180

aagtcgcttc acctcaagca cgcgaagctc acggcgtttg gctccacgcg ccgccccggg      240

gttcgcgtcg aggacgacgc gagcgtgcgg gccgtgctgg acgcttcgac gcctgtggtc      300

gcgatcgtcg ggaaagcctg ggattttcat gtgacggagg ccctccggat cgatctcgac      360

gagaacctcg cgatgatcag ggacaccgtg cagtacttga agcagcacgg gcgcgaggtc      420

atcttcgacg cggagcactt tttcgacgga ttcaagcgaa accgagcgta tgcgctcgcg      480

acggttcggg cggcgtggga ggccggcgtg gactgggtgg cgctttgcga tacgaacggc      540

gggagcatgc cgcacgagat ccacgagatg gtcacacagg tcattcagga agtgccggtc      600

caagtcggca ttcacacgca taacgactgc gaactggcgg tggccaacag cctcgccgcg      660

gttcaggcgg gtgcccggat ggtgcacggg accatcaatg gcatcgggga gcgctgcgga      720

aatgccaatt tggcctccat cattccgaac cttgagctga aactcgggta tccgtgcctg      780

ccttctcgcg accatctgcg gctgctgacg ccggtggccc ggtttgtcgg ggaagtctgc      840

aatctcgtgg cgcacagtta ccagccattc gtcggccaca gcgcgtttgc ccataagggc      900

ggcatccacg tgagcgccat ccagcgagat cccgagacat atgagcacat tcctccggaa      960

ctcgtcggca acgagcgccg cgtcctgctc tcggagttgt cgggcgtttc gaacgtcttg     1020

gcgcaggcgc aggcgttcgg tatcccgacg gaggggcgag agaccgagct taggcgcttg     1080

ctcgagcgca tcaagcagat ggagcacatg gggtatcagt tcgagggcgc cgaggcgtcg     1140

caggaacttt tgttccgtcg cgtcctcaac gatttcacgc cgccttttaa ggtccttgct     1200

gtgcgcgtgg ataccgacgt gcagcgccaa ggcgaggcga cgtctcaggc catcatcaag     1260

ctcgaggtgg acggagaaat cgtccacacc gtgtccgagg gcaacgggcc ggtcaatgcg     1320

ctcgacgcgg tgttgcgcaa ggcgctcgct ccgcatcgcc ccgaaatccg ccgcatgcac     1380

ctcacggact acaaggtccg cgtgttggac gaaaaggatg cgacggcggc cagggtccgc     1440

gtcttgatag aatcgacgga cggcgaacac gtctggcgga cagtcggcgt atcggaaaac     1500

gtgattgccg cgagctggga ggcgctcgtc gatagcatcc agtactacct ggcgctcgtg     1560

gtgccgagcc aggcgctcgt cgaagcttga                                      1590


<210>   870
<211>   511
<212>   PRT
<213>   Moorella thermoacetica ATCC 39073

<400>   870
Ile Leu Ile Tyr Asp Thr Thr Leu Arg Asp Gly Ser Gln Gly Glu Gly 
                5                   10                  15      

Ile Ser Leu Ser Val Glu Asp Lys Leu Lys Ile Ala Ser Arg Leu Asp 
            20                  25                  30          

Arg Leu Gly Val Asp Tyr Ile Glu Gly Gly Trp Pro Trp Ala Asn Pro 
        35                  40                  45              

Lys Asp Met Glu Phe Phe Leu Arg Ala Arg Glu Val Ile Trp Arg Gln 
    50                  55                  60                  

Ala Arg Leu Val Ala Phe Gly Arg Thr Arg Lys Pro Gly Gln Ala Ala 
65                  70                  75                  80  

Ala Glu Asp Ala Asn Leu Leu Ala Ile Lys Arg Ala Gly Val Lys Val 
                85                  90                  95      

Ala Thr Ile Phe Gly Lys Ser Trp Asp Leu His Val Thr Ala Ala Leu 
            100                 105                 110         

Gly Thr Thr Leu Ala Glu Asn Leu Ala Met Ile Gly Asp Ser Val Ala 
        115                 120                 125             

Phe Leu Val Asp Gln Gly Leu Glu Val Ile Tyr Asp Ala Glu His Phe 
    130                 135                 140                 

Phe Asp Gly Phe Lys Ala Asn Pro Asp Tyr Ala Leu Glu Thr Leu Lys 
145                 150                 155                 160 

Ala Ala Ala Lys Ala Gly Ala Ser Trp Ile Val Leu Cys Asp Thr Asn 
                165                 170                 175     

Gly Gly Cys Leu Pro Trp Glu Ile Glu Glu Ala Val Ala Arg Val Arg 
            180                 185                 190         

Gln Glu Ile Gln Val Pro Val Gly Ile His Ala His Asn Asp Gly Asp 
        195                 200                 205             

Leu Ala Val Ala Asn Thr Leu Ala Ala Val Thr Ala Gly Cys Arg Gln 
    210                 215                 220                 

Val Gln Gly Thr Ile Asn Gly Phe Gly Glu Arg Cys Gly Asn Ala Asp 
225                 230                 235                 240 

Leu Cys Ser Val Met Pro Asn Leu Glu Leu Lys Met Gly Tyr Gln Cys 
                245                 250                 255     

Leu Pro Pro Gly Gln Leu Ala Phe Leu Thr Glu Val Ser Arg Tyr Val 
            260                 265                 270         

Ser Glu Ile Ala Asn Val Val Pro Ala Gly Asn Gln Pro Phe Val Gly 
        275                 280                 285             

Tyr Ser Ala Phe Ala His Lys Gly Gly Ile His Val Ser Ala Val Leu 
    290                 295                 300                 

Lys Ala Pro Asp Thr Tyr Glu His Ile Arg Pro Gln Gln Val Gly Asn 
305                 310                 315                 320 

Glu Arg Arg Val Leu Met Ser Asp Gln Ala Gly Ala Ser Asn Leu Arg 
                325                 330                 335     

Cys Lys Ala Glu Glu Met Gly Leu Glu Leu Asn Pro Glu Arg Glu Arg 
            340                 345                 350         

Gly Ile Ile Glu Gly Ile Lys Glu Leu Glu Arg Gln Gly Tyr Gln Phe 
        355                 360                 365             

Glu Gly Ala Asp Ala Ser Leu Glu Leu Phe Leu Arg Lys Thr Thr Gly 
    370                 375                 380                 

Glu Tyr Arg Gln Gln Phe Glu Val Glu Tyr Val Lys Ala Leu Val Glu 
385                 390                 395                 400 

Lys Arg Ala Gly Gln Glu Ala Ile Ser Glu Ala Ile Val Lys Leu Arg 
                405                 410                 415     

Val Gly Asp Gln Val Val His Thr Ala Ala Glu Gly Asn Gly Pro Val 
            420                 425                 430         

Asn Ala Met Asp Asn Ala Leu Arg Lys Ala Leu Glu Glu Val Phe Pro 
        435                 440                 445             

Ala Ile Arg His Met Arg Leu Thr Asp Tyr Lys Val Arg Val Leu Asp 
    450                 455                 460                 

Glu Lys Asp Ala Thr Ser Ala Arg Val Arg Val Leu Ile Glu Ser Arg 
465                 470                 475                 480 

Asp Gly Ser Asn Ser Trp Asn Thr Val Gly Val Ser Thr Asn Ile Ile 
                485                 490                 495     

Glu Ala Ser Trp Glu Ala Leu Leu Asp Ser Met Glu Tyr Ala Leu 
            500                 505                 510     

<210>   871
<211>   516
<212>   PRT
<213>   Pelotomaculum thermopropionicum SI

<400>   871
Met Pro Ser Val Lys Ile Tyr Asp Thr Thr Leu Arg Asp Gly Ala Gln 
                5                   10                  15      

Ala Glu Gly Ile Ser Phe Ser Val Glu Asp Lys Ile Lys Ile Ala Leu 
            20                  25                  30          

Arg Leu Asp Lys Met Gly Phe His Tyr Ile Glu Gly Gly Trp Pro Gly 
        35                  40                  45              

Ser Asn Pro Lys Asp Leu Glu Phe Phe Lys Lys Ile Arg His Cys Pro 
    50                  55                  60                  

Leu Arg His Ala Arg Leu Ala Ala Phe Gly Ser Thr Arg Lys Ala Gly 
65                  70                  75                  80  

Ala Ala Ala Glu Asn Asp Ala Ser Val Lys Ala Ile Ile Asp Ser Gly 
                85                  90                  95      

Val Gln Val Ala Thr Ile Phe Gly Lys Ser Trp Asp Phe His Val Phe 
            100                 105                 110         

Lys Ala Leu Gly Val Thr Leu Glu Glu Asn Leu Ala Met Ile Arg Glu 
        115                 120                 125             

Thr Val Ala Tyr Leu Lys Ser Arg Gly Leu Glu Val Ile Tyr Asp Ala 
    130                 135                 140                 

Glu His Phe Phe Asp Gly Cys Lys Ala Asn Pro Ala Tyr Ala Leu Glu 
145                 150                 155                 160 

Thr Ile Arg Ala Ala Ala Glu Ser Gly Ala Ser Ala Val Val Leu Cys 
                165                 170                 175     

Asp Thr Asn Gly Gly Thr Leu Pro Ala Glu Val Lys Glu Leu Val Glu 
            180                 185                 190         

Lys Ala Arg Ser Val Leu Gly Val Pro Val Gly Ile His Ala His Asn 
        195                 200                 205             

Asp Gly Glu Leu Ala Val Ala Asn Thr Leu Ala Ala Val Gln Ala Gly 
    210                 215                 220                 

Ala Glu Gln Val Gln Gly Thr Val Asn Gly Tyr Gly Glu Arg Cys Gly 
225                 230                 235                 240 

Asn Ala Asn Leu Cys Ser Val Ile Pro Asn Leu Thr Leu Lys Cys Gly 
                245                 250                 255     

Ile Glu Thr Ile Pro Arg Glu Lys Leu Val His Leu Thr Asp Leu Ser 
            260                 265                 270         

His Phe Val Ser Glu Val Ala Asn Ile Ser Pro Asn Pro His Gln Pro 
        275                 280                 285             

Phe Val Gly Ala Ser Ala Phe Ala His Lys Gly Gly Val His Val Ser 
    290                 295                 300                 

Ala Leu Leu Lys Asp Ser Arg Thr Tyr Glu His Ile Ser Pro Gly Glu 
305                 310                 315                 320 

Val Gly Asn Arg Arg Arg Val Leu Val Ser Glu Leu Ser Gly Met Ser 
                325                 330                 335     

Asn Leu Leu Tyr Lys Tyr Lys Glu Leu Asn Leu Asp Ile Glu Arg Gln 
            340                 345                 350         

Ser Pro Glu Gly Lys Arg Ile Leu Glu Asp Ile Lys Lys Leu Glu Ser 
        355                 360                 365             

Gln Gly Phe Gln Phe Glu Asp Ala Glu Gly Ser Phe Glu Leu Leu Val 
    370                 375                 380                 

Arg Lys Thr Asn His Gly Tyr Arg Asp Pro Phe Ile Leu Glu Ala Leu 
385                 390                 395                 400 

Arg Leu Leu Val Glu Ile Lys Glu Asn Thr Pro Ala Tyr Ser Glu Ala 
                405                 410                 415     

Ile Ile Lys Met Arg Val Gly Asp Arg Val Val His Thr Ala Ala Glu 
            420                 425                 430         

Gly Asn Gly Pro Val Asn Ala Leu Asp Asn Ala Leu Arg Lys Ala Leu 
        435                 440                 445             

Tyr Asp Phe Tyr Pro Cys Ile Gly Ser Met His Leu Thr Asp Tyr Lys 
    450                 455                 460                 

Val Arg Val Leu Glu Glu Lys Asp Gly Thr Gly Ala Ala Val Arg Val 
465                 470                 475                 480 

His Ile Gln Thr Gly Asp Gly Lys Arg Ser Trp Gly Thr Val Gly Val 
                485                 490                 495     

Ser Arg Asn Ile Ile Glu Ala Ser Trp Gln Ala Leu Ala Asp Ser Ile 
            500                 505                 510         

Ser Tyr Gly Leu 
        515     

<210>   872
<211>   510
<212>   PRT
<213>   Desulfotomaculum reducens MI-1

<400>   872
Met Tyr Asp Thr Thr Leu Arg Asp Gly Thr Gln Gly Glu Gly Val Ser 
                5                   10                  15      

Leu Ser Ala Glu Asp Lys Val Lys Ile Ala Leu Arg Leu Asp Glu Met 
            20                  25                  30          

Gly Phe Gln Tyr Ile Glu Gly Gly Trp Pro Gly Ser Asn Pro Lys Asp 
        35                  40                  45              

Met Glu Phe Phe Gln Lys Ile Gln Gln Tyr Ser Leu Arg Asn Ala Gln 
    50                  55                  60                  

Val Thr Ala Phe Gly Ser Thr Cys Arg Pro Gly Val Glu Pro His Glu 
65                  70                  75                  80  

Asp Ala Asn Ile Asn Cys Leu Leu Glu Ala Gly Ala Lys Ile Ala Thr 
                85                  90                  95      

Ile Phe Gly Lys Cys Trp Asp Phe His Val Thr Lys Ala Leu Asn Thr 
            100                 105                 110         

Thr Leu Glu Glu Asn Leu Arg Met Val Arg Glu Ser Val Ala Tyr Leu 
        115                 120                 125             

Lys Ser Lys Gly Leu Met Val Phe Phe Asp Gly Glu His Phe Phe Asp 
    130                 135                 140                 

Gly Tyr Lys Ala Asn Ala Asp Tyr Ala Leu Ser Val Leu Lys Ala Ala 
145                 150                 155                 160 

Val Gln Gly Gly Ala Ala Thr Val Ile Leu Cys Asp Thr Asn Gly Gly 
                165                 170                 175     

Ser Met Pro Gln Glu Ile Gln Arg Ala Val Thr His Val Val Glu Glu 
            180                 185                 190         

Leu Pro Gly Val Glu Leu Gly Ile His Ala His Asn Asp Gly Glu Met 
        195                 200                 205             

Ala Val Ala Asn Ser Ile Met Ala Val Gln Ala Gly Val Ser Gln Val 
    210                 215                 220                 

Gln Gly Thr Val Asn Gly Leu Gly Glu Arg Cys Gly Asn Ala Asn Leu 
225                 230                 235                 240 

Cys Ser Ile Ile Pro Asn Leu Ala Leu Lys Met Gly Tyr Ser Thr Ile 
                245                 250                 255     

Pro Ala Glu Asn Leu Val Tyr Leu Thr Glu Leu Ser Arg Tyr Val Tyr 
            260                 265                 270         

Glu Leu Ala Asn Leu Asn Pro Ile Ala Asn Gln Pro Phe Val Gly Glu 
        275                 280                 285             

Ser Ala Phe Ala His Lys Gly Gly Ile His Val Ser Ala Leu Met Lys 
    290                 295                 300                 

Glu Pro Gly Thr Tyr Glu His Met Asn Pro Glu Ala Val Gly Asn Val 
305                 310                 315                 320 

Arg Arg Val Leu Met Ser Glu Leu Ala Gly Ile Ser Asn Leu Leu Tyr 
                325                 330                 335     

Lys Tyr Lys Glu Leu His Leu Asp Lys Ser Ser Pro Glu Gly Arg Gln 
            340                 345                 350         

Val Leu Glu Lys Leu Lys Asn Met Glu His Gly Gly Tyr Gln Phe Glu 
        355                 360                 365             

Ala Ala Glu Gly Ser Leu Glu Leu Met Leu Arg Lys Ala Met Asn Gly 
    370                 375                 380                 

Tyr Arg Glu Pro Phe Gln Leu Glu Ser Met Arg Leu Ile Leu Glu Met 
385                 390                 395                 400 

Arg Glu Glu Asn Pro Ile His Ser Glu Ala Val Ile Lys Leu Lys Val 
                405                 410                 415     

Gly Asp Gln Val Val His Thr Ala Ala Glu Gly Asn Gly Pro Val His 
            420                 425                 430         

Ala Leu Asp Asn Ala Leu Arg Lys Ala Leu Glu Thr Phe Tyr Pro Glu 
        435                 440                 445             

Val Ala Gly Met Arg Leu Ser Asp Tyr Lys Val Arg Val Leu Glu Glu 
    450                 455                 460                 

Lys Ala Gly Thr Glu Ala Arg Val Arg Val Leu Ile Glu Thr Gly Asp 
465                 470                 475                 480 

Gly Lys Lys Thr Trp Gly Thr Val Gly Val Ser Thr Asn Ile Ile Glu 
                485                 490                 495     

Ala Ser Trp Gln Ala Leu Ala Asp Ser Met Ala Tyr Gly Leu 
            500                 505                 510 

<210>   873
<211>   520
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   873
Ile Phe Leu Tyr Asp Thr Thr Leu Arg Asp Gly Thr Gln Arg Glu Gly 
                5                   10                  15      

Leu Ser Leu Ser Leu Ala Asp Lys Leu Lys Ile Ala Arg Glu Leu Asp 
            20                  25                  30          

Arg Phe Gly Met His Tyr Ile Glu Gly Gly Trp Pro Gly Ser Asn Pro 
        35                  40                  45              

Lys Asp Ala Ala Phe Phe Ala Glu Ala Ala Lys Met Glu Trp Lys His 
    50                  55                  60                  

Ala Lys Ile Ala Ala Phe Gly Ser Thr Arg Arg Ala Asn Ser Lys Pro 
65                  70                  75                  80  

Glu Thr Asp Ala Asn Leu Lys Ala Leu Leu Asp Ala Asn Thr Pro Val 
                85                  90                  95      

Val Thr Leu Val Gly Lys Ser Trp Thr Leu His Val Thr Glu Val Leu 
            100                 105                 110         

Glu Thr Thr Leu Glu Glu Asn Leu Ala Met Ile Arg Asp Ser Val Ala 
        115                 120                 125             

Leu Met Lys Ala His Gly Lys Glu Val Ile Tyr Asp Ala Glu His Phe 
    130                 135                 140                 

Phe Asp Gly Tyr Arg Ala Asp Asn Asp Tyr Ala Leu Ala Thr Ile Lys 
145                 150                 155                 160 

Ala Ala Ala Glu Ala Gly Ala Asp Trp Ile Val Leu Cys Asp Thr Asn 
                165                 170                 175     

Gly Gly Ser Leu Pro Asp Trp Ile Ser Ala Val Val Gln Arg Val Lys 
            180                 185                 190         

Gly Lys Ile Asn Thr Gln Leu Gly Ile His Thr His Asn Asp Ser Glu 
        195                 200                 205             

Leu Ala Val Ala Asn Ser Leu Ala Ala Ile Val Gly Gly Cys Arg Gln 
    210                 215                 220                 

Val Gln Gly Thr Ile Asn Gly Tyr Gly Glu Arg Cys Gly Asn Ala Asn 
225                 230                 235                 240 

Leu Ile Ser Ile Ile Pro Asn Leu Gln Leu Lys Met Gly Met Phe Cys 
                245                 250                 255     

Val Leu Pro Asp Gln Leu Gln Arg Leu Thr Glu Leu Ser Arg Thr Val 
            260                 265                 270         

Ser Glu Ile Ala Asn Leu Asn Pro Asp Glu His Ala Ala Tyr Val Gly 
        275                 280                 285             

Asn Ser Ala Phe Ala His Lys Gly Gly Ile His Val Ala Ala Val Ala 
    290                 295                 300                 

Lys Val Glu His Ser Tyr Gln His Ile Glu Pro Val Gln Val Gly Asn 
305                 310                 315                 320 

Arg Lys Arg Val Val Ile Ser Glu Leu Ser Gly Arg Gly Asn Ile Lys 
                325                 330                 335     

Met Arg Ala Glu Glu Leu Gly Val Glu Ser Thr Gly Leu Glu Arg Gly 
            340                 345                 350         

Val Leu Glu Arg Val Lys Leu Leu Glu Ser Lys Gly Phe Gln Phe Glu 
        355                 360                 365             

Ala Ala Glu Gly Ser Phe Glu Leu Leu Val Arg Arg Ala Ala Ala Asp 
    370                 375                 380                 

Tyr Ala Ala Pro Phe Lys Leu Leu Asp Val Val Thr Ile Val Glu Gln 
385                 390                 395                 400 

Arg Arg Gly Val Glu Met Gln Ala Glu Ala Thr Val Lys Leu Gln Ile 
                405                 410                 415     

Gly Glu Glu Ile Tyr His Thr Ala Ala Ser Gly Asn Gly Pro Val Asn 
            420                 425                 430         

Ala Leu Asp Gln Ala Met Arg Lys Ala Leu Leu Ser Arg Tyr Pro Glu 
        435                 440                 445             

Leu Ala Glu Val His Leu Val Asp Tyr Lys Val Arg Ile Leu Asp Ser 
    450                 455                 460                 

Glu Ser Ala Thr Gly Ala Thr Thr Arg Val Leu Ile Glu Ala Ala Met 
465                 470                 475                 480 

Gly Asp Glu Arg Trp Thr Thr Val Gly Cys Ser Glu Asn Ile Ile Glu 
                485                 490                 495     

Ala Ser Trp Gln Ala Leu Val Asp Ser Leu Glu Leu Pro Leu Val Arg 
            500                 505                 510         

Ala Arg Ser Asn Gln Pro Val Leu 
        515                 520 

<210>   874
<211>   515
<212>   PRT
<213>   Aquifex aeolicus VF5

<400>   874
Val Tyr Ile Tyr Asp Thr Thr Leu Arg Asp Gly Ser Gln Met Glu Gly 
                5                   10                  15      

Val Ser Phe Ser Leu Glu Asp Lys Ile Arg Ile Ala Glu Lys Leu Asp 
            20                  25                  30          

Asp Phe Gly Ile His Tyr Ile Glu Gly Gly Trp Pro Tyr Ala Asn Pro 
        35                  40                  45              

Lys Asp Asn Leu Phe Phe Gln Lys Ala Lys Lys Met Asn Phe Lys Asn 
    50                  55                  60                  

Ala Lys Leu Thr Ala Phe Gly Ser Thr Arg Arg Pro Asn Lys Lys Val 
65                  70                  75                  80  

Ser Glu Asp Pro Gln Val Glu Ser Leu Ile Lys Ala Glu Thr Pro Val 
                85                  90                  95      

Val Thr Ile Phe Gly Lys Ser Trp Asp Leu His Val Thr Asp Ala Leu 
            100                 105                 110         

Lys Thr Thr Leu Glu Glu Asn Leu Asn Met Ile Tyr Glu Thr Val Glu 
        115                 120                 125             

Tyr Leu Lys Arg Tyr Val Asp Glu Val Ile Phe Asp Ala Glu His Phe 
    130                 135                 140                 

Phe Asp Gly Tyr Lys Ser Asn Pro Glu Tyr Ala Leu Gln Val Leu Glu 
145                 150                 155                 160 

Ala Ala Leu Lys Gly Gly Ala Asp Trp Val Val Leu Cys Asp Thr Asn 
                165                 170                 175     

Gly Gly Thr Leu Pro His Glu Ile Tyr Glu Ile Thr Lys Lys Val Lys 
            180                 185                 190         

Glu Arg Phe Lys Asp Ala Asn Val Gly Ile His Ala His Asn Asp Ser 
        195                 200                 205             

Glu Thr Ala Val Ala Asn Ser Leu Met Ala Val Leu Ala Gly Ala Arg 
    210                 215                 220                 

Gln Val His Gly Thr Ile Asn Gly Ile Gly Glu Arg Thr Gly Asn Ala 
225                 230                 235                 240 

Asn Leu Cys Ser Ile Ile Pro Asn Leu Gln Leu Lys Leu Gly Phe Asp 
                245                 250                 255     

Val Ile Pro Gln Glu Asn Leu Lys Lys Leu Thr Glu Leu Ala Asn Phe 
            260                 265                 270         

Val Ala Glu Ile Ile Asn Met Pro Leu Pro Arg Asn Met Pro Tyr Val 
        275                 280                 285             

Gly Glu Ser Ala Phe Ala His Lys Gly Gly Val His Ala Ser Ala Val 
    290                 295                 300                 

Leu Lys Asn Ala Lys Thr Tyr Glu His Ile Asn Pro Glu Leu Val Gly 
305                 310                 315                 320 

Asn Lys Arg Lys Ile Thr Val Ser Asp Leu Ala Gly Arg Ser Asn Leu 
                325                 330                 335     

Val His Lys Leu Lys Glu Phe Gly Ile Glu Ile Asp Pro Lys Ser Pro 
            340                 345                 350         

Glu Leu Lys Lys Leu Ile Asp Lys Ile Lys Glu Leu Glu Lys Glu Gly 
        355                 360                 365             

Tyr His Phe Glu Ala Ala Glu Ala Ser Leu Glu Leu Leu Ile Lys Arg 
    370                 375                 380                 

His Phe Gly Leu Val Lys Asp Tyr Phe Asp Phe Asp Ala Tyr Arg Val 
385                 390                 395                 400 

Leu Ile Ala Lys Arg Arg Asp Asp Ser Leu Pro Thr Ser Glu Ala Thr 
                405                 410                 415     

Val Arg Leu Ser Val Glu Gly Val Glu Glu His Thr Ala Ser Leu Gly 
            420                 425                 430         

Asn Gly Pro Ile Ser Ala Leu Asp Arg Ala Leu Arg Lys Ala Leu Glu 
        435                 440                 445             

Glu Phe Tyr Pro Asn Leu Lys Glu Leu Gln Leu Ile Asp Tyr Lys Val 
    450                 455                 460                 

Arg Ile Ile Asn Glu Ser Ala Gly Thr Ser Ala Lys Val Arg Val Leu 
465                 470                 475                 480 

Ile Glu Ser Thr Asp Gly Lys Arg Lys Trp Gly Thr Val Gly Val Ser 
                485                 490                 495     

Glu Asn Val Ile Glu Ala Ser Trp Ile Ala Leu Arg Asp Ser Ile Val 
            500                 505                 510         

Tyr Lys Leu 
        515 

<210>   875
<211>   529
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 868

<400>   875
Met Ser Tyr Val Tyr Leu Leu Asp Thr Thr Leu Arg Asp Gly Thr Gln 
                5                   10                  15      

Gly Glu Gly Val Ser Leu Thr Val Ala Asp Lys Leu Lys Ile Ala Glu 
            20                  25                  30          

Lys Leu Asp Asp Leu Gly Val Ala Tyr Ile Glu Gly Gly Phe Pro Gly 
        35                  40                  45              

Ala Asn Pro Lys Asp Glu Glu Phe Phe Arg Ala Ala Lys Ser Leu His 
    50                  55                  60                  

Leu Lys His Ala Lys Leu Thr Ala Phe Gly Ser Thr Arg Arg Pro Gly 
65                  70                  75                  80  

Val Arg Val Glu Asp Asp Ala Ser Val Arg Ala Val Leu Asp Ala Ser 
                85                  90                  95      

Thr Pro Val Val Ala Ile Val Gly Lys Ala Trp Asp Phe His Val Thr 
            100                 105                 110         

Glu Ala Leu Arg Ile Asp Leu Asp Glu Asn Leu Ala Met Ile Arg Asp 
        115                 120                 125             

Thr Val Gln Tyr Leu Lys Gln His Gly Arg Glu Val Ile Phe Asp Ala 
    130                 135                 140                 

Glu His Phe Phe Asp Gly Phe Lys Arg Asn Arg Ala Tyr Ala Leu Ala 
145                 150                 155                 160 

Thr Val Arg Ala Ala Trp Glu Ala Gly Val Asp Trp Val Ala Leu Cys 
                165                 170                 175     

Asp Thr Asn Gly Gly Ser Met Pro His Glu Ile His Glu Met Val Thr 
            180                 185                 190         

Gln Val Ile Gln Glu Val Pro Val Gln Val Gly Ile His Thr His Asn 
        195                 200                 205             

Asp Cys Glu Leu Ala Val Ala Asn Ser Leu Ala Ala Val Gln Ala Gly 
    210                 215                 220                 

Ala Arg Met Val His Gly Thr Ile Asn Gly Ile Gly Glu Arg Cys Gly 
225                 230                 235                 240 

Asn Ala Asn Leu Ala Ser Ile Ile Pro Asn Leu Glu Leu Lys Leu Gly 
                245                 250                 255     

Tyr Pro Cys Leu Pro Ser Arg Asp His Leu Arg Leu Leu Thr Pro Val 
            260                 265                 270         

Ala Arg Phe Val Gly Glu Val Cys Asn Leu Val Ala His Ser Tyr Gln 
        275                 280                 285             

Pro Phe Val Gly His Ser Ala Phe Ala His Lys Gly Gly Ile His Val 
    290                 295                 300                 

Ser Ala Ile Gln Arg Asp Pro Glu Thr Tyr Glu His Ile Pro Pro Glu 
305                 310                 315                 320 

Leu Val Gly Asn Glu Arg Arg Val Leu Leu Ser Glu Leu Ser Gly Val 
                325                 330                 335     

Ser Asn Val Leu Ala Gln Ala Gln Ala Phe Gly Ile Pro Thr Glu Gly 
            340                 345                 350         

Arg Glu Thr Glu Leu Arg Arg Leu Leu Glu Arg Ile Lys Gln Met Glu 
        355                 360                 365             

His Met Gly Tyr Gln Phe Glu Gly Ala Glu Ala Ser Gln Glu Leu Leu 
    370                 375                 380                 

Phe Arg Arg Val Leu Asn Asp Phe Thr Pro Pro Phe Lys Val Leu Ala 
385                 390                 395                 400 

Val Arg Val Asp Thr Asp Val Gln Arg Gln Gly Glu Ala Thr Ser Gln 
                405                 410                 415     

Ala Leu Ile Lys Leu Glu Val Asp Gly Glu Ile Val His Thr Val Ser 
            420                 425                 430         

Glu Gly Asn Gly Pro Val Asn Ala Leu Asp Ala Val Leu Arg Lys Ala 
        435                 440                 445             

Leu Ala Pro His Arg Pro Glu Ile Arg Arg Met His Leu Thr Asp Tyr 
    450                 455                 460                 

Lys Val Arg Val Leu Asp Glu Lys Asp Ala Thr Ala Ala Arg Val Arg 
465                 470                 475                 480 

Val Leu Ile Glu Ser Thr Asp Gly Glu His Val Trp Arg Thr Val Gly 
                485                 490                 495     

Val Ser Glu Asn Val Ile Ala Ala Ser Trp Glu Ala Leu Val Asp Ser 
            500                 505                 510         

Ile Gln Tyr Tyr Leu Ala Leu Val Val Pro Ser Gln Ala Leu Val Glu 
        515                 520                 525             

Ala 
    

<210>   876
<211>   529
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 868

<400>   876
Met Ser Tyr Val Tyr Leu Leu Asp Thr Thr Leu Arg Asp Gly Thr Gln 
                5                   10                  15      

Gly Glu Gly Val Ser Leu Thr Val Ala Asp Lys Leu Lys Ile Ala Glu 
            20                  25                  30          

Lys Leu Asp Asp Leu Gly Val Ala Tyr Ile Glu Gly Gly Phe Pro Gly 
        35                  40                  45              

Ala Asn Pro Lys Asp Glu Glu Phe Phe Arg Ala Ala Arg Ser Leu His 
    50                  55                  60                  

Leu Lys His Ala Lys Leu Thr Ala Phe Gly Ser Thr Arg Arg Pro Gly 
65                  70                  75                  80  

Val Arg Val Glu Asp Asp Ala Ser Val Arg Ala Val Leu Asp Ala Ser 
                85                  90                  95      

Thr Pro Val Val Ala Ile Val Gly Lys Ala Trp Asp Phe His Val Thr 
            100                 105                 110         

Glu Ala Leu Arg Ile Asp Leu Asp Glu Asn Leu Ala Met Ile Arg Asp 
        115                 120                 125             

Thr Val Gln Tyr Leu Lys Gln His Gly Arg Glu Val Ile Phe Asp Ala 
    130                 135                 140                 

Glu His Phe Phe Asp Gly Phe Lys Arg Asn Arg Ala Tyr Ala Leu Ala 
145                 150                 155                 160 

Thr Val Arg Ala Ala Trp Glu Ala Gly Val Asp Trp Val Ala Leu Cys 
                165                 170                 175     

Asp Thr Asn Gly Gly Ser Met Pro His Glu Ile His Glu Met Val Thr 
            180                 185                 190         

Gln Val Ile Gln Glu Val Pro Val Gln Val Gly Ile His Thr His Asn 
        195                 200                 205             

Asp Cys Glu Leu Ala Val Ala Asn Ser Leu Ala Ala Val Gln Ala Gly 
    210                 215                 220                 

Ala Arg Met Val His Gly Thr Ile Asn Gly Ile Gly Glu Arg Cys Gly 
225                 230                 235                 240 

Asn Ala Asn Leu Ala Ser Ile Ile Pro Asn Leu Glu Leu Lys Leu Gly 
                245                 250                 255     

Tyr Pro Cys Leu Pro Ser Arg Asp His Leu Arg Leu Leu Thr Pro Val 
            260                 265                 270         

Ala Arg Phe Val Gly Glu Val Cys Asn Leu Val Ala His Ser Tyr Gln 
        275                 280                 285             

Pro Phe Val Gly His Ser Ala Phe Ala His Lys Gly Gly Ile His Val 
    290                 295                 300                 

Ser Ala Ile Gln Arg Asp Pro Glu Thr Tyr Glu His Ile Pro Pro Glu 
305                 310                 315                 320 

Leu Val Gly Asn Glu Arg Arg Val Leu Leu Ser Glu Leu Ser Gly Val 
                325                 330                 335     

Ser Asn Val Leu Ala Gln Ala Gln Ala Phe Gly Ile Pro Thr Glu Gly 
            340                 345                 350         

Arg Glu Thr Glu Leu Arg Arg Leu Leu Glu Arg Ile Lys Gln Met Glu 
        355                 360                 365             

His Met Gly Tyr Gln Phe Glu Gly Ala Glu Ala Ser Gln Glu Leu Leu 
    370                 375                 380                 

Phe Arg Arg Val Leu Asn Asp Phe Thr Pro Pro Phe Lys Val Leu Ala 
385                 390                 395                 400 

Val Arg Val Asp Thr Asp Val Gln Arg Gln Gly Glu Ala Thr Ser Gln 
                405                 410                 415     

Ala Ile Ile Lys Leu Glu Val Asp Gly Glu Ile Val His Thr Val Ser 
            420                 425                 430         

Glu Gly Asn Gly Pro Val Asn Ala Leu Asp Ala Val Leu Arg Lys Ala 
        435                 440                 445             

Leu Ala Pro His Arg Pro Glu Ile Arg Arg Met His Leu Thr Asp Tyr 
    450                 455                 460                 

Lys Val Arg Val Leu Asp Glu Lys Asp Ala Thr Ala Ala Arg Val Arg 
465                 470                 475                 480 

Val Leu Ile Glu Ser Thr Asp Gly Glu His Val Trp Arg Thr Val Gly 
                485                 490                 495     

Val Ser Glu Asn Val Ile Ala Ala Ser Trp Glu Ala Leu Val Asp Ser 
            500                 505                 510         

Ile Gln Tyr Tyr Leu Ala Leu Val Val Pro Ser Gln Ala Leu Val Glu 
        515                 520                 525             

Ala 
    

<210>   877
<211>   529
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 868

<400>   877
Met Ser Tyr Val Tyr Leu Leu Asp Thr Thr Leu Arg Asp Gly Thr Gln 
                5                   10                  15      

Gly Glu Gly Val Ser Leu Thr Val Ala Asp Lys Leu Lys Ile Ala Glu 
            20                  25                  30          

Lys Leu Asp Asp Leu Gly Val Ala Tyr Ile Glu Gly Gly Phe Pro Gly 
        35                  40                  45              

Ala Asn Pro Lys Asp Glu Glu Phe Phe Arg Ala Ala Lys Ser Leu His 
    50                  55                  60                  

Leu Lys His Ala Lys Leu Thr Ala Phe Gly Ser Thr Arg Arg Pro Gly 
65                  70                  75                  80  

Val Arg Val Glu Asp Asp Ala Ser Val Arg Ala Val Leu Asp Ala Ser 
                85                  90                  95      

Thr Pro Val Val Ala Ile Val Gly Lys Ala Trp Asp Phe His Val Thr 
            100                 105                 110         

Glu Ala Leu Arg Ile Asp Leu Asp Glu Asn Leu Ala Met Ile Arg Asp 
        115                 120                 125             

Thr Val Gln Tyr Leu Lys Gln His Gly Arg Glu Val Ile Phe Asp Ala 
    130                 135                 140                 

Glu His Phe Phe Asp Gly Phe Lys Arg Asn Arg Ala Tyr Ala Leu Ala 
145                 150                 155                 160 

Thr Val Arg Ala Ala Trp Glu Ala Gly Val Asp Trp Val Ala Leu Cys 
                165                 170                 175     

Asp Thr Asn Gly Gly Ser Met Pro His Glu Ile His Glu Met Val Thr 
            180                 185                 190         

Gln Val Ile Gln Glu Val Pro Val Gln Val Gly Ile His Thr His Asn 
        195                 200                 205             

Asp Cys Glu Leu Ala Val Ala Asn Ser Leu Ala Ala Val Gln Ala Gly 
    210                 215                 220                 

Ala Arg Met Val His Gly Thr Ile Asn Gly Ile Gly Glu Arg Cys Gly 
225                 230                 235                 240 

Asn Ala Asn Leu Ala Ser Ile Ile Pro Asn Leu Glu Leu Lys Leu Gly 
                245                 250                 255     

Tyr Pro Cys Leu Pro Ser Arg Asp His Leu Arg Leu Leu Thr Pro Val 
            260                 265                 270         

Ala Arg Phe Val Gly Glu Val Cys Asn Leu Val Ala His Ser Tyr Gln 
        275                 280                 285             

Pro Phe Val Gly His Ser Ala Phe Ala His Lys Gly Gly Ile His Val 
    290                 295                 300                 

Ser Ala Ile Gln Arg Asp Pro Glu Thr Tyr Glu His Ile Pro Pro Glu 
305                 310                 315                 320 

Leu Val Gly Asn Glu Arg Arg Val Leu Leu Ser Glu Leu Ser Gly Val 
                325                 330                 335     

Ser Asn Val Leu Ala Gln Ala Gln Ala Phe Gly Ile Pro Thr Glu Gly 
            340                 345                 350         

Arg Glu Thr Glu Leu Arg Arg Leu Leu Glu Arg Ile Lys Gln Met Glu 
        355                 360                 365             

His Met Gly Tyr Gln Phe Glu Gly Ala Glu Ala Ser Gln Glu Leu Leu 
    370                 375                 380                 

Phe Arg Arg Val Leu Asn Asp Phe Thr Pro Pro Phe Lys Val Leu Ala 
385                 390                 395                 400 

Val Arg Val Asp Thr Asp Val Gln Arg Gln Gly Glu Ala Thr Ser Gln 
                405                 410                 415     

Ala Ile Ile Lys Leu Glu Val Asp Gly Glu Ile Val His Thr Val Ser 
            420                 425                 430         

Asp Gly Asn Gly Pro Val Asn Ala Leu Asp Ala Val Leu Arg Lys Ala 
        435                 440                 445             

Leu Ala Pro His Arg Pro Glu Ile Arg Arg Met His Leu Thr Asp Tyr 
    450                 455                 460                 

Lys Val Arg Val Leu Asp Glu Lys Asp Ala Thr Ala Ala Arg Val Arg 
465                 470                 475                 480 

Val Leu Ile Glu Ser Thr Asp Gly Glu His Val Trp Arg Thr Val Gly 
                485                 490                 495     

Val Ser Glu Asn Val Ile Ala Ala Ser Trp Glu Ala Leu Val Asp Ser 
            500                 505                 510         

Ile Gln Tyr Tyr Leu Ala Leu Val Val Pro Ser Gln Ala Leu Val Glu 
        515                 520                 525             

Ala 
    

<210>   878
<211>   529
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 868

<400>   878
Met Ser Tyr Val Tyr Leu Leu Asp Thr Thr Leu Arg Asp Gly Thr Gln 
                5                   10                  15      

Gly Glu Gly Val Ser Leu Thr Val Ala Asp Lys Leu Lys Ile Ala Glu 
            20                  25                  30          

Lys Leu Asp Asp Leu Gly Val Ala Tyr Ile Glu Gly Gly Phe Pro Gly 
        35                  40                  45              

Ala Asn Pro Lys Asp Glu Glu Phe Phe Arg Ala Ala Lys Ser Leu His 
    50                  55                  60                  

Leu Lys His Ala Lys Leu Thr Ala Phe Gly Ser Thr Arg Arg Pro Gly 
65                  70                  75                  80  

Val Arg Val Glu Asp Asp Ala Ser Val Arg Ala Val Leu Asp Ala Ser 
                85                  90                  95      

Thr Pro Val Val Ala Ile Val Gly Lys Ala Trp Asp Phe His Val Thr 
            100                 105                 110         

Glu Ala Leu Arg Leu Asp Leu Asp Glu Asn Leu Ala Met Ile Arg Asp 
        115                 120                 125             

Thr Val Gln Tyr Leu Lys Gln His Gly Arg Glu Val Ile Phe Asp Ala 
    130                 135                 140                 

Glu His Phe Phe Asp Gly Phe Lys Arg Asn Arg Ala Tyr Ala Leu Ala 
145                 150                 155                 160 

Thr Val Arg Ala Ala Trp Glu Ala Gly Val Asp Trp Val Ala Leu Cys 
                165                 170                 175     

Asp Thr Asn Gly Gly Ser Met Pro His Glu Ile His Glu Met Val Thr 
            180                 185                 190         

Gln Val Ile Gln Glu Val Pro Val Gln Val Gly Ile His Thr His Asn 
        195                 200                 205             

Asp Cys Glu Leu Ala Val Ala Asn Ser Leu Ala Ala Val Gln Ala Gly 
    210                 215                 220                 

Ala Arg Met Val His Gly Thr Ile Asn Gly Ile Gly Glu Arg Cys Gly 
225                 230                 235                 240 

Asn Ala Asn Leu Ala Ser Ile Ile Pro Asn Leu Glu Leu Lys Leu Gly 
                245                 250                 255     

Tyr Pro Cys Leu Pro Ser Arg Asp His Leu Arg Leu Leu Thr Pro Val 
            260                 265                 270         

Ala Arg Phe Val Gly Glu Val Cys Asn Leu Val Ala His Ser Tyr Gln 
        275                 280                 285             

Pro Phe Val Gly His Ser Ala Phe Ala His Lys Gly Gly Ile His Val 
    290                 295                 300                 

Ser Ala Ile Gln Arg Asp Pro Glu Thr Tyr Glu His Ile Pro Pro Glu 
305                 310                 315                 320 

Leu Val Gly Asn Glu Arg Arg Val Leu Leu Ser Glu Leu Ser Gly Val 
                325                 330                 335     

Ser Asn Val Leu Ala Gln Ala Gln Ala Phe Gly Ile Pro Thr Glu Gly 
            340                 345                 350         

Arg Glu Thr Glu Leu Arg Arg Leu Leu Glu Arg Ile Lys Gln Met Glu 
        355                 360                 365             

His Met Gly Tyr Gln Phe Glu Gly Ala Glu Ala Ser Gln Glu Leu Leu 
    370                 375                 380                 

Phe Arg Arg Val Leu Asn Asp Phe Thr Pro Pro Phe Lys Val Leu Ala 
385                 390                 395                 400 

Val Arg Val Asp Thr Asp Val Gln Arg Gln Gly Glu Ala Thr Ser Gln 
                405                 410                 415     

Ala Ile Ile Lys Leu Glu Val Asp Gly Glu Ile Val His Thr Val Ser 
            420                 425                 430         

Glu Gly Asn Gly Pro Val Asn Ala Leu Asp Ala Val Leu Arg Lys Ala 
        435                 440                 445             

Leu Ala Pro His Arg Pro Glu Ile Arg Arg Met His Leu Thr Asp Tyr 
    450                 455                 460                 

Lys Val Arg Val Leu Asp Glu Lys Asp Ala Thr Ala Ala Arg Val Arg 
465                 470                 475                 480 

Val Leu Ile Glu Ser Thr Asp Gly Glu His Val Trp Arg Thr Val Gly 
                485                 490                 495     

Val Ser Glu Asn Val Ile Ala Ala Ser Trp Glu Ala Leu Val Asp Ser 
            500                 505                 510         

Ile Gln Tyr Tyr Leu Ala Leu Val Val Pro Ser Gln Ala Leu Val Glu 
        515                 520                 525             

Ala 
    

<210>   879
<211>   529
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 868

<400>   879
Met Ser Tyr Val Tyr Leu Leu Asp Thr Thr Leu Arg Asp Gly Thr Gln 
                5                   10                  15      

Gly Glu Gly Val Ser Leu Thr Val Ala Asp Lys Leu Lys Ile Ala Glu 
            20                  25                  30          

Lys Leu Asp Asp Leu Gly Val Ala Tyr Ile Glu Gly Gly Phe Pro Gly 
        35                  40                  45              

Ala Asn Pro Lys Asp Glu Glu Phe Phe Arg Ala Ala Lys Ser Leu His 
    50                  55                  60                  

Leu Lys His Ala Lys Leu Thr Ala Phe Gly Ser Thr Arg Arg Pro Gly 
65                  70                  75                  80  

Val Arg Val Glu Asp Asp Ala Ser Val Lys Ala Val Leu Asp Ala Ser 
                85                  90                  95      

Thr Pro Val Val Ala Ile Val Gly Lys Ala Trp Asp Phe His Val Thr 
            100                 105                 110         

Glu Ala Leu Arg Ile Asp Leu Asp Glu Asn Leu Ala Met Ile Arg Asp 
        115                 120                 125             

Thr Val Gln Tyr Leu Lys Gln His Gly Arg Glu Val Ile Phe Asp Ala 
    130                 135                 140                 

Glu His Phe Phe Asp Gly Phe Lys Arg Asn Arg Ala Tyr Ala Leu Ala 
145                 150                 155                 160 

Thr Val Arg Ala Ala Trp Glu Ala Gly Val Asp Trp Val Ala Leu Cys 
                165                 170                 175     

Asp Thr Asn Gly Gly Ser Met Pro His Glu Ile His Glu Met Val Thr 
            180                 185                 190         

Gln Val Ile Gln Glu Val Pro Val Gln Val Gly Ile His Thr His Asn 
        195                 200                 205             

Asp Cys Glu Leu Ala Val Ala Asn Ser Leu Ala Ala Val Gln Ala Gly 
    210                 215                 220                 

Ala Arg Met Val His Gly Thr Ile Asn Gly Ile Gly Glu Arg Cys Gly 
225                 230                 235                 240 

Asn Ala Asn Leu Ala Ser Ile Ile Pro Asn Leu Glu Leu Lys Leu Gly 
                245                 250                 255     

Tyr Pro Cys Leu Pro Ser Arg Asp His Leu Arg Leu Leu Thr Pro Val 
            260                 265                 270         

Ala Arg Phe Val Gly Glu Val Cys Asn Leu Val Ala His Ser Tyr Gln 
        275                 280                 285             

Pro Phe Val Gly His Ser Ala Phe Ala His Lys Gly Gly Ile His Val 
    290                 295                 300                 

Ser Ala Ile Gln Arg Asp Pro Glu Thr Tyr Glu His Ile Pro Pro Glu 
305                 310                 315                 320 

Leu Val Gly Asn Glu Arg Arg Val Leu Leu Ser Glu Leu Ser Gly Val 
                325                 330                 335     

Ser Asn Val Leu Ala Gln Ala Gln Ala Phe Gly Ile Pro Thr Glu Gly 
            340                 345                 350         

Arg Glu Thr Glu Leu Arg Arg Leu Leu Glu Arg Ile Lys Gln Met Glu 
        355                 360                 365             

His Met Gly Tyr Gln Phe Glu Gly Ala Glu Ala Ser Gln Glu Leu Leu 
    370                 375                 380                 

Phe Arg Arg Val Leu Asn Asp Phe Thr Pro Pro Phe Lys Val Leu Ala 
385                 390                 395                 400 

Val Arg Val Asp Thr Asp Val Gln Arg Gln Gly Glu Ala Thr Ser Gln 
                405                 410                 415     

Ala Ile Ile Lys Leu Glu Val Asp Gly Glu Ile Val His Thr Val Ser 
            420                 425                 430         

Glu Gly Asn Gly Pro Val Asn Ala Leu Asp Ala Val Leu Arg Lys Ala 
        435                 440                 445             

Leu Ala Pro His Arg Pro Glu Ile Arg Arg Met His Leu Thr Asp Tyr 
    450                 455                 460                 

Lys Val Arg Val Leu Asp Glu Lys Asp Ala Thr Ala Ala Arg Val Arg 
465                 470                 475                 480 

Val Leu Ile Glu Ser Thr Asp Gly Glu His Val Trp Arg Thr Val Gly 
                485                 490                 495     

Val Ser Glu Asn Val Ile Ala Ala Ser Trp Glu Ala Leu Val Asp Ser 
            500                 505                 510         

Ile Gln Tyr Tyr Leu Ala Leu Val Val Pro Ser Gln Ala Leu Val Glu 
        515                 520                 525             

Ala 
    

<210>   880
<211>   1590
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 869

<400>   880
atgagctacg tgtatttgct cgataccaca ttgcgggatg gcacgcaggg cgagggggtc       60

agcctcaccg tcgccgacaa actcaagatt gcagaaaagt tggacgatct cggcgtcgcc      120

tacatcgaag gcggctttcc gggcgcgaat ccgaaggatg aggagttttt ccgcgccgcg      180

aagtcgcttc acctcaagca cgcgaagctc acggcgtttg gctccacgcg ccgccccggg      240

gttcgcgtcg aggacgacgc gagcgtgcgg gccgtgctgg acgcttcgac gcctgtggtc      300

gcgatcgtcg ggaaagcctg ggattttcat gtgacggagg ccctccggat cgatctcgac      360

gagaacctcg cgatgatcag ggacaccgtg cagtacttga agcagcacgg gcgcgaggtc      420

atcttcgacg cggagcactt tttcgacgga ttcaagcgaa accgagcgta tgcgctcgcg      480

acggttcggg cggcgtggga ggccggcgtg gactgggtgg cgctttgcga tacgaacggc      540

gggagcatgc cgcacgagat ccacgagatg gtcacacagg tcattcagga agtgccggtc      600

caagtcggca ttcacacgca taacgactgc gaactggcgg tggccaacag cctcgccgcg      660

gttcaggcgg gtgcccggat ggtgcacggg accatcaatg gcatcgggga gcgctgcgga      720

aatgccaatt tggcctccat cattccgaac cttgagctga aactcgggta tccgtgcctg      780

ccttctcgcg accatctgcg gctgctgacg ccggtggccc ggtttgtcgg ggaagtctgc      840

aatctcgtgg cgcacagtta ccagccattc gtcggccaca gcgcgtttgc ccataagggc      900

ggcatccacg tgagcgccat ccagcgagat cccgagacat atgagcacat tcctccggaa      960

ctcgtcggca acgagcgccg cgtcctgctc tcggagttgt cgggcgtttc gaacgtcttg     1020

gcgcaggcgc aggcgttcgg tatcccgacg gaggggcgag agaccgagct taggcgcttg     1080

ctcgagcgca tcaagcagat ggagcacatg gggtatcagt tcgagggcgc cgaggcgtcg     1140

caggaacttt tgttccgtcg cgtcctcaac gatttcacgc cgccttttaa ggtccttgct     1200

gtgcgcgtgg ataccgacgt gcagcgccaa ggcgaggcga cgtctcaggc cttaatcaag     1260

ctcgaggtgg acggagaaat cgtccacacc gtgtccgagg gcaacgggcc ggtcaatgcg     1320

ctcgacgcgg tgttgcgcaa ggcgctcgct ccgcatcgcc ccgaaatccg ccgcatgcac     1380

ctcacggact acaaggtccg cgtgttggac gaaaaggatg cgacggcggc cagggtccgc     1440

gtcttgatag aatcgacgga cggcgaacac gtctggcgga cagtcggcgt atcggaaaac     1500

gtgattgccg cgagctggga ggcgctcgtc gatagcatcc agtactacct ggcgctcgtg     1560

gtgccgagcc aggcgctcgt cgaagcttga                                      1590


<210>   881
<211>   1590
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 869

<400>   881
atgagctacg tgtatttgct cgataccaca ttgcgggatg gcacgcaggg cgagggggtc       60

agcctcaccg tcgccgacaa actcaagatt gcagaaaagt tggacgatct cggcgtcgcc      120

tacatcgaag gcggctttcc gggcgcgaat ccgaaggatg aggagttttt ccgcgccgcg      180

cgttcgcttc acctcaagca cgcgaagctc acggcgtttg gctccacgcg ccgccccggg      240

gttcgcgtcg aggacgacgc gagcgtgcgg gccgtgctgg acgcttcgac gcctgtggtc      300

gcgatcgtcg ggaaagcctg ggattttcat gtgacggagg ccctccggat cgatctcgac      360

gagaacctcg cgatgatcag ggacaccgtg cagtacttga agcagcacgg gcgcgaggtc      420

atcttcgacg cggagcactt tttcgacgga ttcaagcgaa accgagcgta tgcgctcgcg      480

acggttcggg cggcgtggga ggccggcgtg gactgggtgg cgctttgcga tacgaacggc      540

gggagcatgc cgcacgagat ccacgagatg gtcacacagg tcattcagga agtgccggtc      600

caagtcggca ttcacacgca taacgactgc gaactggcgg tggccaacag cctcgccgcg      660

gttcaggcgg gtgcccggat ggtgcacggg accatcaatg gcatcgggga gcgctgcgga      720

aatgccaatt tggcctccat cattccgaac cttgagctga aactcgggta tccgtgcctg      780

ccttctcgcg accatctgcg gctgctgacg ccggtggccc ggtttgtcgg ggaagtctgc      840

aatctcgtgg cgcacagtta ccagccattc gtcggccaca gcgcgtttgc ccataagggc      900

ggcatccacg tgagcgccat ccagcgagat cccgagacat atgagcacat tcctccggaa      960

ctcgtcggca acgagcgccg cgtcctgctc tcggagttgt cgggcgtttc gaacgtcttg     1020

gcgcaggcgc aggcgttcgg tatcccgacg gaggggcgag agaccgagct taggcgcttg     1080

ctcgagcgca tcaagcagat ggagcacatg gggtatcagt tcgagggcgc cgaggcgtcg     1140

caggaacttt tgttccgtcg cgtcctcaac gatttcacgc cgccttttaa ggtccttgct     1200

gtgcgcgtgg ataccgacgt gcagcgccaa ggcgaggcga cgtctcaggc catcatcaag     1260

ctcgaggtgg acggagaaat cgtccacacc gtgtccgagg gcaacgggcc ggtcaatgcg     1320

ctcgacgcgg tgttgcgcaa ggcgctcgct ccgcatcgcc ccgaaatccg ccgcatgcac     1380

ctcacggact acaaggtccg cgtgttggac gaaaaggatg cgacggcggc cagggtccgc     1440

gtcttgatag aatcgacgga cggcgaacac gtctggcgga cagtcggcgt atcggaaaac     1500

gtgattgccg cgagctggga ggcgctcgtc gatagcatcc agtactacct ggcgctcgtg     1560

gtgccgagcc aggcgctcgt cgaagcttga                                      1590


<210>   882
<211>   1590
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 869

<400>   882
atgagctacg tgtatttgct cgataccaca ttgcgggatg gcacgcaggg cgagggggtc       60

agcctcaccg tcgccgacaa actcaagatt gcagaaaagt tggacgatct cggcgtcgcc      120

tacatcgaag gcggctttcc gggcgcgaat ccgaaggatg aggagttttt ccgcgccgcg      180

aagtcgcttc acctcaagca cgcgaagctc acggcgtttg gctccacgcg ccgccccggg      240

gttcgcgtcg aggacgacgc gagcgtgcgg gccgtgctgg acgcttcgac gcctgtggtc      300

gcgatcgtcg ggaaagcctg ggattttcat gtgacggagg ccctccggat cgatctcgac      360

gagaacctcg cgatgatcag ggacaccgtg cagtacttga agcagcacgg gcgcgaggtc      420

atcttcgacg cggagcactt tttcgacgga ttcaagcgaa accgagcgta tgcgctcgcg      480

acggttcggg cggcgtggga ggccggcgtg gactgggtgg cgctttgcga tacgaacggc      540

gggagcatgc cgcacgagat ccacgagatg gtcacacagg tcattcagga agtgccggtc      600

caagtcggca ttcacacgca taacgactgc gaactggcgg tggccaacag cctcgccgcg      660

gttcaggcgg gtgcccggat ggtgcacggg accatcaatg gcatcgggga gcgctgcgga      720

aatgccaatt tggcctccat cattccgaac cttgagctga aactcgggta tccgtgcctg      780

ccttctcgcg accatctgcg gctgctgacg ccggtggccc ggtttgtcgg ggaagtctgc      840

aatctcgtgg cgcacagtta ccagccattc gtcggccaca gcgcgtttgc ccataagggc      900

ggcatccacg tgagcgccat ccagcgagat cccgagacat atgagcacat tcctccggaa      960

ctcgtcggca acgagcgccg cgtcctgctc tcggagttgt cgggcgtttc gaacgtcttg     1020

gcgcaggcgc aggcgttcgg tatcccgacg gaggggcgag agaccgagct taggcgcttg     1080

ctcgagcgca tcaagcagat ggagcacatg gggtatcagt tcgagggcgc cgaggcgtcg     1140

caggaacttt tgttccgtcg cgtcctcaac gatttcacgc cgccttttaa ggtccttgct     1200

gtgcgcgtgg ataccgacgt gcagcgccaa ggcgaggcga cgtctcaggc catcatcaag     1260

ctcgaggtgg acggagaaat cgtccacacc gtgtccgatg gcaacgggcc ggtcaatgcg     1320

ctcgacgcgg tgttgcgcaa ggcgctcgct ccgcatcgcc ccgaaatccg ccgcatgcac     1380

ctcacggact acaaggtccg cgtgttggac gaaaaggatg cgacggcggc cagggtccgc     1440

gtcttgatag aatcgacgga cggcgaacac gtctggcgga cagtcggcgt atcggaaaac     1500

gtgattgccg cgagctggga ggcgctcgtc gatagcatcc agtactacct ggcgctcgtg     1560

gtgccgagcc aggcgctcgt cgaagcttga                                      1590


<210>   883
<211>   1590
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 869

<400>   883
atgagctacg tgtatttgct cgataccaca ttgcgggatg gcacgcaggg cgagggggtc       60

agcctcaccg tcgccgacaa actcaagatt gcagaaaagt tggacgatct cggcgtcgcc      120

tacatcgaag gcggctttcc gggcgcgaat ccgaaggatg aggagttttt ccgcgccgcg      180

aagtcgcttc acctcaagca cgcgaagctc acggcgtttg gctccacgcg ccgccccggg      240

gttcgcgtcg aggacgacgc gagcgtgcgg gccgtgctgg acgcttcgac gcctgtggtc      300

gcgatcgtcg ggaaagcctg ggattttcat gtgacggagg ccctccggtt agatctcgac      360

gagaacctcg cgatgatcag ggacaccgtg cagtacttga agcagcacgg gcgcgaggtc      420

atcttcgacg cggagcactt tttcgacgga ttcaagcgaa accgagcgta tgcgctcgcg      480

acggttcggg cggcgtggga ggccggcgtg gactgggtgg cgctttgcga tacgaacggc      540

gggagcatgc cgcacgagat ccacgagatg gtcacacagg tcattcagga agtgccggtc      600

caagtcggca ttcacacgca taacgactgc gaactggcgg tggccaacag cctcgccgcg      660

gttcaggcgg gtgcccggat ggtgcacggg accatcaatg gcatcgggga gcgctgcgga      720

aatgccaatt tggcctccat cattccgaac cttgagctga aactcgggta tccgtgcctg      780

ccttctcgcg accatctgcg gctgctgacg ccggtggccc ggtttgtcgg ggaagtctgc      840

aatctcgtgg cgcacagtta ccagccattc gtcggccaca gcgcgtttgc ccataagggc      900

ggcatccacg tgagcgccat ccagcgagat cccgagacat atgagcacat tcctccggaa      960

ctcgtcggca acgagcgccg cgtcctgctc tcggagttgt cgggcgtttc gaacgtcttg     1020

gcgcaggcgc aggcgttcgg tatcccgacg gaggggcgag agaccgagct taggcgcttg     1080

ctcgagcgca tcaagcagat ggagcacatg gggtatcagt tcgagggcgc cgaggcgtcg     1140

caggaacttt tgttccgtcg cgtcctcaac gatttcacgc cgccttttaa ggtccttgct     1200

gtgcgcgtgg ataccgacgt gcagcgccaa ggcgaggcga cgtctcaggc catcatcaag     1260

ctcgaggtgg acggagaaat cgtccacacc gtgtccgagg gcaacgggcc ggtcaatgcg     1320

ctcgacgcgg tgttgcgcaa ggcgctcgct ccgcatcgcc ccgaaatccg ccgcatgcac     1380

ctcacggact acaaggtccg cgtgttggac gaaaaggatg cgacggcggc cagggtccgc     1440

gtcttgatag aatcgacgga cggcgaacac gtctggcgga cagtcggcgt atcggaaaac     1500

gtgattgccg cgagctggga ggcgctcgtc gatagcatcc agtactacct ggcgctcgtg     1560

gtgccgagcc aggcgctcgt cgaagcttga                                      1590


<210>   884
<211>   1590
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 869

<400>   884
atgagctacg tgtatttgct cgataccaca ttgcgggatg gcacgcaggg cgagggggtc       60

agcctcaccg tcgccgacaa actcaagatt gcagaaaagt tggacgatct cggcgtcgcc      120

tacatcgaag gcggctttcc gggcgcgaat ccgaaggatg aggagttttt ccgcgccgcg      180

aagtcgcttc acctcaagca cgcgaagctc acggcgtttg gctccacgcg ccgccccggg      240

gttcgcgtcg aggacgacgc gagcgtgaaa gccgtgctgg acgcttcgac gcctgtggtc      300

gcgatcgtcg ggaaagcctg ggattttcat gtgacggagg ccctccggat cgatctcgac      360

gagaacctcg cgatgatcag ggacaccgtg cagtacttga agcagcacgg gcgcgaggtc      420

atcttcgacg cggagcactt tttcgacgga ttcaagcgaa accgagcgta tgcgctcgcg      480

acggttcggg cggcgtggga ggccggcgtg gactgggtgg cgctttgcga tacgaacggc      540

gggagcatgc cgcacgagat ccacgagatg gtcacacagg tcattcagga agtgccggtc      600

caagtcggca ttcacacgca taacgactgc gaactggcgg tggccaacag cctcgccgcg      660

gttcaggcgg gtgcccggat ggtgcacggg accatcaatg gcatcgggga gcgctgcgga      720

aatgccaatt tggcctccat cattccgaac cttgagctga aactcgggta tccgtgcctg      780

ccttctcgcg accatctgcg gctgctgacg ccggtggccc ggtttgtcgg ggaagtctgc      840

aatctcgtgg cgcacagtta ccagccattc gtcggccaca gcgcgtttgc ccataagggc      900

ggcatccacg tgagcgccat ccagcgagat cccgagacat atgagcacat tcctccggaa      960

ctcgtcggca acgagcgccg cgtcctgctc tcggagttgt cgggcgtttc gaacgtcttg     1020

gcgcaggcgc aggcgttcgg tatcccgacg gaggggcgag agaccgagct taggcgcttg     1080

ctcgagcgca tcaagcagat ggagcacatg gggtatcagt tcgagggcgc cgaggcgtcg     1140

caggaacttt tgttccgtcg cgtcctcaac gatttcacgc cgccttttaa ggtccttgct     1200

gtgcgcgtgg ataccgacgt gcagcgccaa ggcgaggcga cgtctcaggc catcatcaag     1260

ctcgaggtgg acggagaaat cgtccacacc gtgtccgagg gcaacgggcc ggtcaatgcg     1320

ctcgacgcgg tgttgcgcaa ggcgctcgct ccgcatcgcc ccgaaatccg ccgcatgcac     1380

ctcacggact acaaggtccg cgtgttggac gaaaaggatg cgacggcggc cagggtccgc     1440

gtcttgatag aatcgacgga cggcgaacac gtctggcgga cagtcggcgt atcggaaaac     1500

gtgattgccg cgagctggga ggcgctcgtc gatagcatcc agtactacct ggcgctcgtg     1560

gtgccgagcc aggcgctcgt cgaagcttga                                      1590


<210>   885
<211>   358
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   885
Met Asp Asp Val Gln Val Tyr Arg Phe Thr Gly Asp Thr Lys Pro Asp 
                5                   10                  15      

Gln Val Leu Asn Glu Ala Gly Glu Met Val Gly Glu Leu Pro Glu Asn 
            20                  25                  30          

Ala Ala Asp Leu Ala Leu Glu Trp Tyr Pro Phe Met Ile Phe Cys Arg 
        35                  40                  45              

Lys Phe Asp Glu Arg Ala Gln Leu Leu Gln Arg Gln Gly Arg Leu Gly 
    50                  55                  60                  

Thr Tyr Ala Pro Phe Arg Gly Gln Glu Ala Ala Gln Ile Ala Ser Phe 
65                  70                  75                  80  

Ala Val Leu Arg Pro Ser Asp Trp Val Phe Pro Thr Tyr Arg Glu Leu 
                85                  90                  95      

Ala Gly Met Met Tyr His Gly Leu Glu Pro Val His Ala Leu Leu Lys 
            100                 105                 110         

Ser Arg Gly His Pro Asp Ala Gly Arg Met Pro Glu Glu Ile His Met 
        115                 120                 125             

Ala Pro Pro Gln Ile Ala Ile Ala Ala Gln Ile Leu His Ala Val Gly 
    130                 135                 140                 

Ala Gly Trp Ala Cys Lys Leu Gln Glu Lys Asp Asp Ile Ala Val Ala 
145                 150                 155                 160 

Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Gly Met 
                165                 170                 175     

Asn Phe Ala Ser Val Met Arg Leu Pro Val Val Phe Phe Cys Gln Asn 
            180                 185                 190         

Asn Gln Tyr Ala Ile Ser Val Pro Val His Arg Gln Met Ala Ser Pro 
        195                 200                 205             

Thr Ile Ala Gln Lys Ala Ile Ala Tyr Gly Met Glu Gly Leu Arg Val 
    210                 215                 220                 

Asp Gly Asn Asp Ala Phe Ala Val Tyr Gln Ala Met Cys Tyr Ala Val 
225                 230                 235                 240 

Glu Arg Ala Arg Arg Gly Asp Gly Pro Thr Leu Ile Glu Ala Val Thr 
                245                 250                 255     

Tyr Arg Leu Gly Pro His Thr Thr Ala Asp Asp Pro Gly Arg Tyr Arg 
            260                 265                 270         

Asp Ala Val Asp Val Glu Arg Trp Ala Ala Ala Lys Asp Pro Leu Val 
        275                 280                 285             

Arg Leu Arg Leu Trp Leu Thr Arg Gln Gly Leu Trp Asp Asp Glu Arg 
    290                 295                 300                 

Gln Ala Ala Cys Glu Glu Glu Ala Glu Ala Arg Val Arg Gln Ala Val 
305                 310                 315                 320 

Ala Asp Met Glu Ala Tyr Pro His Lys Ser Leu Glu Glu Ala Ala Arg 
                325                 330                 335     

His Val Tyr Ala Glu Val Pro Glu Ala Leu Ala Leu His Leu Ala Lys 
            340                 345                 350         

Arg Gly Lys Glu Ala Arg 
        355             

<210>   886
<211>   1077
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   886
gtggatgacg tgcaggttta ccggttcacg ggcgacacaa aaccggatca ggtgctgaat       60

gaggcgggcg agatggtggg cgagttgccc gagaacgcgg ccgatctcgc cctcgagtgg      120

taccctttca tgatcttctg ccgaaaattc gacgagcgcg cgcaactcct gcagcggcag      180

gggcggctcg gaacctacgc gccgtttcgc ggccaggagg cggcgcagat cgccagtttt      240

gccgtgcttc gtccgagcga ttgggtgttt cccacgtacc gcgagctcgc cggcatgatg      300

taccacgggc tggaacctgt gcacgccctg ctcaagagcc gcggacatcc ggacgcaggc      360

cgcatgccgg aagagatcca catggcgcct cctcagatcg ccatcgcggc gcagatttta      420

cacgcggtgg gcgcgggctg ggcgtgcaag ttgcaggaga aggacgacat cgccgtggcg      480

tatttcggtg acggtgcgac gtccgaggga gattttcacg agggcatgaa cttcgcttcc      540

gtcatgcgcc tgcccgtcgt gttcttctgc cagaacaacc agtacgccat cagcgtgccc      600

gtgcatcggc agatggcgtc gccgaccatc gcgcaaaagg ccatcgcgta cggcatggag      660

ggcctcaggg tcgacgggaa cgacgccttc gccgtgtatc aggcgatgtg ctacgccgtc      720

gagcgggcgc gccgtgggga cggcccgacg ctcatcgagg cggtcacgta tcgcctgggt      780

ccgcacacga ccgcggacga tcccggaagg tatcgggacg ccgtggatgt ggagcgatgg      840

gcggcggcca aagacccgct cgtgaggctc aggctctggc ttacgcgaca gggactctgg      900

gacgatgagc ggcaagccgc gtgtgaagag gaggccgaag cgcgcgtgcg ccaggcggtg      960

gccgacatgg aagcgtaccc gcataagtcc ctcgaggagg ccgcgcgcca cgtgtacgcc     1020

gaggtcccgg aggcactcgc gcttcatctc gccaaacgcg gaaaggaggc gcgctga        1077


<210>   887
<211>   331
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   887
Gln Ile Leu Asp Glu Asn Gly Asn Gly Asp Glu Ala Lys Ile Ala Ala 
                5                   10                  15      

Phe Ser Asp Glu Trp Leu Leu Asp Ala Tyr Arg Ala Met Arg Arg Ala 
            20                  25                  30          

Arg Val Val Asp Glu Arg Leu Leu Arg Met Gln Arg Gln Gly Arg Ile 
        35                  40                  45              

Gly Thr Tyr Ala Pro Phe Ser Gly Gln Glu Ala Ala Gln Ile Gly Ser 
    50                  55                  60                  

Val Leu Ala Leu Gln Lys Asp Asp Trp Ile Phe Pro Ser Tyr Arg Glu 
65                  70                  75                  80  

Val Ala Val Cys Leu Thr His Gly Met Pro Leu Glu Gln Phe Phe His 
                85                  90                  95      

Tyr Val Arg Gly Arg Leu Ser Gly Lys Arg Met Pro Glu Glu Leu Asn 
            100                 105                 110         

Ile Phe Pro Thr Gln Ile Ile Ile Ala Ala Gln Thr Leu His Ala Val 
        115                 120                 125             

Gly Cys Ala Trp Ala Thr Lys Leu Lys Gly Glu Ser His Val Ser Val 
    130                 135                 140                 

Ala Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Ala 
145                 150                 155                 160 

Met Asn Phe Ala Ala Val Tyr Asn Val Pro Val Ile Phe Phe Cys Gln 
                165                 170                 175     

Asn Asn Gln Tyr Ala Ile Ser Val Pro Tyr Ala Lys Gln Thr Ala Ser 
            180                 185                 190         

Arg Thr Ile Ala Gln Lys Ala Leu Ala Tyr Gly Met Lys Gly Val Leu 
        195                 200                 205             

Val Asp Gly Asn Asp Val Leu Ala Val Tyr Glu Thr Met Lys Gln Ala 
    210                 215                 220                 

Val Glu Ala Ala Arg Arg Gly Glu Gly Pro Met Leu Ile Glu Ala Leu 
225                 230                 235                 240 

Thr Tyr Arg Leu Gly Pro His Thr Thr Ala Asp Asp Pro Thr Lys Tyr 
                245                 250                 255     

Arg His Pro Glu Glu Val Glu Thr Trp Arg Arg Lys Asp Pro Leu His 
            260                 265                 270         

Arg Leu Arg Val Leu Leu Glu Arg Arg Gly Leu Trp Thr Asp Ala Lys 
        275                 280                 285             

Glu Glu Glu Phe Val Ala Lys Val Asn Glu Glu Val Thr Ala Ala Tyr 
    290                 295                 300                 

Glu Ala Ala Val Ala Ser Glu Ser Gly Ser Ile Ala Asp Val Phe Asp 
305                 310                 315                 320 

Tyr Val Tyr Ser Glu Ala Pro Lys Leu Leu Ala 
                325                 330     

<210>   888
<211>   342
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   888
Phe Asp Pro Asp Lys Leu Pro Val Glu Ile Val Arg Ile Leu Asp Glu 
                5                   10                  15      

Asn Gly Asn Gly Asp Glu Glu Lys Leu Ala Ala Phe Ser Asp Glu Trp 
            20                  25                  30          

Leu Leu Arg Ala Tyr Arg Glu Met Arg Arg Ala Arg Val Ile Asp Glu 
        35                  40                  45              

Arg Leu Leu Arg Met Gln Arg Gln Gly Arg Ile Gly Thr Tyr Ala Pro 
    50                  55                  60                  

Phe Ser Gly Gln Glu Ala Ala Gln Ile Gly Ser Ala Leu Ala Leu His 
65                  70                  75                  80  

Lys Asp Asp Trp Ile Phe Pro Ser Tyr Arg Glu Val Ala Val Cys Leu 
                85                  90                  95      

Met His Gly Met Pro Leu Glu Gln Phe Phe His Tyr Val Gln Gly Arg 
            100                 105                 110         

Leu Ser Gly Lys Arg Met Pro Glu Gly Val Asn Ile Phe Pro Thr Gln 
        115                 120                 125             

Ile Ile Ile Ala Ala Gln Thr Leu His Ala Val Gly Cys Ala Trp Ala 
    130                 135                 140                 

Ser Lys Leu Lys Gly Glu Pro His Val Ser Val Ala Tyr Phe Gly Asp 
145                 150                 155                 160 

Gly Ala Thr Ser Glu Gly Asp Phe His Glu Ala Met Asn Phe Ala Ala 
                165                 170                 175     

Val Tyr Asn Val Pro Val Ile Phe Phe Cys Gln Asn Asn Gln Tyr Ala 
            180                 185                 190         

Ile Ser Val Pro Tyr Arg Lys Gln Thr Ala Ser Arg Thr Ile Ala Gln 
        195                 200                 205             

Lys Ala Leu Ala Tyr Gly Met Lys Gly Val Leu Val Asp Gly Asn Asp 
    210                 215                 220                 

Val Leu Ala Val Tyr Glu Thr Met Lys Gln Ala Val Glu Ala Ala Arg 
225                 230                 235                 240 

Arg Gly Glu Gly Pro Met Leu Ile Glu Ala Leu Thr Tyr Arg Leu Gly 
                245                 250                 255     

Pro His Thr Thr Ala Asp Asp Pro Thr Lys Tyr Arg Arg Pro Glu Glu 
            260                 265                 270         

Val Glu Thr Trp Arg Ala Lys Asp Pro Leu Arg Arg Leu Arg Leu Leu 
        275                 280                 285             

Leu Glu Arg Arg Gly Leu Trp Thr Glu Ala Gln Glu Asp Ala Leu Val 
    290                 295                 300                 

Ala Gln Val Asn Asp Glu Val Thr Ala Ala Tyr Glu Ala Ala Ile Ala 
305                 310                 315                 320 

Ser Lys Ser Gly Ser Ile Val Asp Ala Phe Asp Cys Val Tyr Ser Glu 
                325                 330                 335     

Ala Pro Lys Leu Leu Ala 
            340         

<210>   889
<211>   329
<212>   PRT
<213>   Exiguobacterium sibiricum 255-15

<400>   889
Arg Ile Leu Asp Asp Ala Gly Gln Val Thr Asp Thr Ser Lys Thr Asp 
                5                   10                  15      

Leu Leu Thr Lys Asp Leu Ser Leu Ala Leu Phe Thr His Met Asn Arg 
            20                  25                  30          

Ile Arg Thr Phe Asp Arg Lys Ala Ile Asn Leu Gln Arg Gln Gly Arg 
        35                  40                  45              

Leu Gly Thr Tyr Ala Pro Phe Glu Gly Gln Glu Ala Ala Gln Val Gly 
    50                  55                  60                  

Ser Ala Tyr Ala Leu Gln Asp Lys Asp Trp Val Phe Pro Thr Tyr Arg 
65                  70                  75                  80  

Asp His Gly Ala Thr Leu Thr Phe Gly Ala Asp Met Val Arg Thr Phe 
                85                  90                  95      

Leu Tyr Trp Asn Gly Arg Val Glu Gly Cys Val Ala Thr Asp Glu Leu 
            100                 105                 110         

His Ile Phe Pro Pro Ala Val Pro Ile Ala Thr Gln Ile Pro His Ala 
        115                 120                 125             

Val Gly Ala Ala Trp Ala Glu Lys Arg Lys Gly Ser Thr Gln Val Ala 
    130                 135                 140                 

Val Ala Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu 
145                 150                 155                 160 

Gly Met Asn Phe Ala Ser Val Phe Gln Ala Pro Val Ile Leu Phe Asn 
                165                 170                 175     

Gln Asn Asn Gly Tyr Ala Ile Ser Val Pro Ile Gln Lys Gln Met His 
            180                 185                 190         

Ser Glu Thr Ile Ala Gln Lys Ala Leu Ala Tyr Gly Met Pro Ser Val 
        195                 200                 205             

Arg Ile Asp Gly Asn Asp Val Phe Ala Val Tyr Phe Thr Met Gln Lys 
    210                 215                 220                 

Ala Leu Glu Arg Ala Arg Ser Gly Gly Gly Pro Thr Leu Ile Glu Ala 
225                 230                 235                 240 

Val Thr Trp Arg Phe Gly Ala His Thr Thr Ala Asp Asp Pro Ser Lys 
                245                 250                 255     

Tyr Arg Asp Gln Glu Arg Ser Arg Asp Arg Val Asp Pro Leu Glu Arg 
            260                 265                 270         

Leu Glu Ala Phe Met Lys Glu Gln Gly Phe Tyr Asp Glu Gln Glu Ile 
        275                 280                 285             

Glu Thr Ile Arg Ser Arg His Gln Glu Glu Val Glu Ala Ala Val Lys 
    290                 295                 300                 

Thr Met Glu Ser Phe Pro Pro Pro Asp Val Asn Asp Leu Phe Asp His 
305                 310                 315                 320 

Thr Phe Ala Thr Leu Pro Asp Asp Leu 
                325                 

<210>   890
<211>   329
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   890
Gln Val Leu Thr Pro Lys Gly Glu Cys Gln Tyr Glu Gly Ser Glu Phe 
                5                   10                  15      

Leu Asp Lys Thr Phe Val Leu Ser Met Tyr Lys Gln Met Ile Asn Cys 
            20                  25                  30          

Arg Glu Phe Asp Glu Lys Ala Leu Lys Leu Gln Arg Gln Gly Arg Ile 
        35                  40                  45              

Gly Thr Tyr Ala Ser Phe Lys Gly Gln Glu Ala Cys Gln Ile Gly Gly 
    50                  55                  60                  

Ala Leu Ala Leu Arg Pro Thr Asp Trp Leu Phe Pro Thr Tyr Arg Asp 
65                  70                  75                  80  

His Ala Ala Ile Ser Thr His Gly Gln Pro Trp His Arg Ile Phe Leu 
                85                  90                  95      

Tyr Trp Met Gly His Met Asp Gly Ser Leu Ser Pro Asp Asp Arg Asn 
            100                 105                 110         

Ile Leu Pro Pro Ala Val Pro Ile Ala Thr Gln Met Leu His Ala Val 
        115                 120                 125             

Gly Thr Ala Trp Ala Asp Lys Leu Lys Gly Asn Pro His Val Ser Leu 
    130                 135                 140                 

Val Phe Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Ala 
145                 150                 155                 160 

Leu Asn Phe Ala Gly Val Tyr Gln Thr Pro Thr Ile Phe Phe Cys Gln 
                165                 170                 175     

Asn Asn Gly Tyr Ala Ile Ser Val Pro Phe Glu Lys Gln Ser Ala Ser 
            180                 185                 190         

Lys Thr Ile Lys Gln Arg Ser Val Ala Tyr Asp Met Arg Gly Glu Arg 
        195                 200                 205             

Val Asp Gly Asn Asp Ile Phe Ala Val Tyr Leu Thr Val Lys Arg Ala 
    210                 215                 220                 

Ile Glu Gln Ala Arg Lys Gly Arg Gly Pro Thr Leu Ile Glu Ala Val 
225                 230                 235                 240 

Thr Thr Arg Phe Gly Ser His Thr Thr Ala Asp Asp Ala Lys Lys Tyr 
                245                 250                 255     

Arg Asp Gln Glu Glu Ile Glu Arg Thr Trp Lys Glu Met Gln Asp Pro 
            260                 265                 270         

Leu Thr Arg Leu Lys Ala Tyr Ile Gln Ala Lys Gly Trp Leu Ser Glu 
        275                 280                 285             

Glu Glu Glu Ala Gln Met Lys Ala Lys Ile Arg Glu Thr Ile Asp Glu 
    290                 295                 300                 

Glu Leu Ser Met Ala Glu Gln Tyr Pro Lys Pro Ser Ile Ser Gln Met 
305                 310                 315                 320 

Phe Glu His Val Tyr Glu Asn Gln Pro 
                325                 

<210>   891
<211>   350
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   891
Arg Ile Leu Gln Ala Asp Gly Thr Leu Leu Glu Pro Val Pro Ala Phe 
                5                   10                  15      

Leu Ser Val Asp Gln Leu Lys Asp Val Tyr Arg Lys Met Val Tyr Leu 
            20                  25                  30          

Arg Val Phe Asp Gln Arg Cys Leu Asn Leu Gln Arg Gln Gly Arg Met 
        35                  40                  45              

Gly Thr Phe Ala Pro Phe Ser Gly Gln Glu Ala Ser Gln Val Gly Ser 
    50                  55                  60                  

Ala Tyr Leu Leu Arg Pro Asp Arg Asp Trp Ile Phe Pro Thr Tyr Arg 
65                  70                  75                  80  

Asp His Gly Ala Met His Val Met Gly Val Pro Leu Val Asn Ile Leu 
                85                  90                  95      

Arg Tyr Phe Met Gly Asp Glu Gln Gly Ser His Ala Pro Gln Gly Val 
            100                 105                 110         

Asn Ala Phe Pro Ile Ser Ile Pro Ile Ala Thr Gln Leu Leu His Ala 
        115                 120                 125             

Val Gly Ala Ala Trp Ala Gly Arg Ile Lys Gly Glu Asp Thr Val Ala 
    130                 135                 140                 

Val Gly Tyr Ala Gly Asp Gly Gly Thr Ser Pro Gly Asp Phe His Glu 
145                 150                 155                 160 

Ala Leu Asn Phe Ala Ala Val Phe Asn Val Pro Val Ile Phe Phe Ile 
                165                 170                 175     

Gln Asn Asn Arg Tyr Ala Ile Ser Thr Pro Asn Ser Arg Gln Phe Lys 
            180                 185                 190         

Thr Pro Thr Ile Ala Gln Arg Ala Leu Gly Tyr Asp Ile Ala Gly Val 
        195                 200                 205             

Arg Val Asp Gly Gln Asp Val Leu Ala Val Leu Ala Val Met His Glu 
    210                 215                 220                 

Ala Ile Glu Arg Ala Arg Ser Gly Gly Gly Pro Thr Leu Val Glu Ser 
225                 230                 235                 240 

Val Thr Phe Arg Tyr Gly Pro His Thr Thr Ser Asp Asp Pro Lys Arg 
                245                 250                 255     

Tyr Arg Ser Gln Glu Glu Leu Glu Glu Trp Gln Ala Arg Asp Pro Ile 
            260                 265                 270         

Glu Arg Leu Arg Leu Tyr Leu Val Ser Gln Gly Gln Trp Ser Asp Ser 
        275                 280                 285             

Asp Asp Glu Ala Leu Trp Thr Ala Ala Arg Glu Gln Val Ala Ala Ala 
    290                 295                 300                 

Val Ala Glu Ala Glu Ala Met Pro Arg Pro Ser Val Asp Asp Leu Phe 
305                 310                 315                 320 

Asp Tyr Leu Tyr Ala Glu Pro Thr Pro Asn Leu Val Arg Gln Lys Glu 
                325                 330                 335     

Tyr Leu Lys Ala Tyr Leu Ala Lys Lys Glu Gly Gly Ala Arg 
            340                 345                 350 

<210>   892
<211>   358
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 885

<400>   892
Met Asp Asp Val Gln Ile Tyr Arg Phe Thr Gly Asp Thr Lys Pro Asp 
                5                   10                  15      

Gln Val Leu Asn Glu Ala Gly Glu Met Val Gly Glu Leu Pro Glu Asn 
            20                  25                  30          

Ala Ala Asp Leu Ala Leu Glu Trp Tyr Pro Phe Met Ile Phe Cys Arg 
        35                  40                  45              

Lys Phe Asp Glu Arg Ala Gln Leu Leu Gln Arg Gln Gly Arg Leu Gly 
    50                  55                  60                  

Thr Tyr Ala Pro Phe Arg Gly Gln Glu Ala Ala Gln Ile Ala Ser Phe 
65                  70                  75                  80  

Ala Val Leu Arg Pro Ser Asp Trp Val Phe Pro Thr Tyr Arg Glu Leu 
                85                  90                  95      

Ala Gly Met Met Tyr His Gly Leu Glu Pro Val His Ala Leu Leu Lys 
            100                 105                 110         

Ser Arg Gly His Pro Asp Ala Gly Arg Met Pro Glu Glu Ile His Met 
        115                 120                 125             

Ala Pro Pro Gln Ile Ala Ile Ala Ala Gln Ile Leu His Ala Val Gly 
    130                 135                 140                 

Ala Gly Trp Ala Cys Lys Leu Gln Glu Lys Asp Asp Ile Ala Val Ala 
145                 150                 155                 160 

Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Gly Met 
                165                 170                 175     

Asn Phe Ala Ser Val Met Arg Leu Pro Val Val Phe Phe Cys Gln Asn 
            180                 185                 190         

Asn Gln Tyr Ala Ile Ser Val Pro Val His Arg Gln Met Ala Ser Pro 
        195                 200                 205             

Thr Ile Ala Gln Lys Ala Ile Ala Tyr Gly Met Glu Gly Leu Arg Val 
    210                 215                 220                 

Asp Gly Asn Asp Ala Phe Ala Val Tyr Gln Ala Met Cys Tyr Ala Val 
225                 230                 235                 240 

Glu Arg Ala Arg Arg Gly Asp Gly Pro Thr Leu Ile Glu Ala Val Thr 
                245                 250                 255     

Tyr Arg Leu Gly Pro His Thr Thr Ala Asp Asp Pro Gly Arg Tyr Arg 
            260                 265                 270         

Asp Ala Val Asp Val Glu Arg Trp Ala Ala Ala Lys Asp Pro Leu Val 
        275                 280                 285             

Arg Leu Arg Leu Trp Leu Thr Arg Gln Gly Leu Trp Asp Asp Glu Arg 
    290                 295                 300                 

Gln Ala Ala Cys Glu Glu Glu Ala Glu Ala Arg Val Arg Gln Ala Val 
305                 310                 315                 320 

Ala Asp Met Glu Ala Tyr Pro His Lys Ser Leu Glu Glu Ala Ala Arg 
                325                 330                 335     

His Val Tyr Ala Glu Val Pro Glu Ala Leu Ala Leu His Leu Ala Lys 
            340                 345                 350         

Arg Gly Lys Glu Ala Arg 
        355             

<210>   893
<211>   358
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 885

<400>   893
Met Asp Asp Val Gln Val Tyr Arg Phe Thr Gly Asp Thr Lys Pro Asp 
                5                   10                  15      

Gln Val Leu Asn Glu Ala Gly Glu Met Val Gly Glu Leu Pro Glu Asn 
            20                  25                  30          

Ala Ala Asp Leu Ala Leu Glu Trp Tyr Pro Phe Met Ile Phe Cys Arg 
        35                  40                  45              

Lys Phe Asp Glu Arg Ala Gln Ile Leu Gln Arg Gln Gly Arg Leu Gly 
    50                  55                  60                  

Thr Tyr Ala Pro Phe Arg Gly Gln Glu Ala Ala Gln Ile Ala Ser Phe 
65                  70                  75                  80  

Ala Val Leu Arg Pro Ser Asp Trp Val Phe Pro Thr Tyr Arg Glu Leu 
                85                  90                  95      

Ala Gly Met Met Tyr His Gly Leu Glu Pro Val His Ala Leu Leu Lys 
            100                 105                 110         

Ser Arg Gly His Pro Asp Ala Gly Arg Met Pro Glu Glu Ile His Met 
        115                 120                 125             

Ala Pro Pro Gln Ile Ala Ile Ala Ala Gln Ile Leu His Ala Val Gly 
    130                 135                 140                 

Ala Gly Trp Ala Cys Lys Leu Gln Glu Lys Asp Asp Ile Ala Val Ala 
145                 150                 155                 160 

Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Gly Met 
                165                 170                 175     

Asn Phe Ala Ser Val Met Arg Leu Pro Val Val Phe Phe Cys Gln Asn 
            180                 185                 190         

Asn Gln Tyr Ala Ile Ser Val Pro Val His Arg Gln Met Ala Ser Pro 
        195                 200                 205             

Thr Ile Ala Gln Lys Ala Ile Ala Tyr Gly Met Glu Gly Leu Arg Val 
    210                 215                 220                 

Asp Gly Asn Asp Ala Phe Ala Val Tyr Gln Ala Met Cys Tyr Ala Val 
225                 230                 235                 240 

Glu Arg Ala Arg Arg Gly Asp Gly Pro Thr Leu Ile Glu Ala Val Thr 
                245                 250                 255     

Tyr Arg Leu Gly Pro His Thr Thr Ala Asp Asp Pro Gly Arg Tyr Arg 
            260                 265                 270         

Asp Ala Val Asp Val Glu Arg Trp Ala Ala Ala Lys Asp Pro Leu Val 
        275                 280                 285             

Arg Leu Arg Leu Trp Leu Thr Arg Gln Gly Leu Trp Asp Asp Glu Arg 
    290                 295                 300                 

Gln Ala Ala Cys Glu Glu Glu Ala Glu Ala Arg Val Arg Gln Ala Val 
305                 310                 315                 320 

Ala Asp Met Glu Ala Tyr Pro His Lys Ser Leu Glu Glu Ala Ala Arg 
                325                 330                 335     

His Val Tyr Ala Glu Val Pro Glu Ala Leu Ala Leu His Leu Ala Lys 
            340                 345                 350         

Arg Gly Lys Glu Ala Arg 
        355             

<210>   894
<211>   358
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 885

<400>   894
Met Asp Asp Val Gln Val Tyr Arg Phe Thr Gly Asp Thr Lys Pro Asp 
                5                   10                  15      

Gln Val Leu Asn Glu Ala Gly Glu Met Val Gly Glu Leu Pro Glu Asn 
            20                  25                  30          

Ala Ala Asp Leu Ala Leu Glu Trp Tyr Pro Phe Met Ile Phe Cys Arg 
        35                  40                  45              

Arg Phe Asp Glu Arg Ala Gln Leu Leu Gln Arg Gln Gly Arg Leu Gly 
    50                  55                  60                  

Thr Tyr Ala Pro Phe Arg Gly Gln Glu Ala Ala Gln Ile Ala Ser Phe 
65                  70                  75                  80  

Ala Val Leu Arg Pro Ser Asp Trp Val Phe Pro Thr Tyr Arg Glu Leu 
                85                  90                  95      

Ala Gly Met Met Tyr His Gly Leu Glu Pro Val His Ala Leu Leu Lys 
            100                 105                 110         

Ser Arg Gly His Pro Asp Ala Gly Arg Met Pro Glu Glu Ile His Met 
        115                 120                 125             

Ala Pro Pro Gln Ile Ala Ile Ala Ala Gln Ile Leu His Ala Val Gly 
    130                 135                 140                 

Ala Gly Trp Ala Cys Lys Leu Gln Glu Lys Asp Asp Ile Ala Val Ala 
145                 150                 155                 160 

Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Gly Met 
                165                 170                 175     

Asn Phe Ala Ser Val Met Arg Leu Pro Val Val Phe Phe Cys Gln Asn 
            180                 185                 190         

Asn Gln Tyr Ala Ile Ser Val Pro Val His Arg Gln Met Ala Ser Pro 
        195                 200                 205             

Thr Ile Ala Gln Lys Ala Ile Ala Tyr Gly Met Glu Gly Leu Arg Val 
    210                 215                 220                 

Asp Gly Asn Asp Ala Phe Ala Val Tyr Gln Ala Met Cys Tyr Ala Val 
225                 230                 235                 240 

Glu Arg Ala Arg Arg Gly Asp Gly Pro Thr Leu Ile Glu Ala Val Thr 
                245                 250                 255     

Tyr Arg Leu Gly Pro His Thr Thr Ala Asp Asp Pro Gly Arg Tyr Arg 
            260                 265                 270         

Asp Ala Val Asp Val Glu Arg Trp Ala Ala Ala Lys Asp Pro Leu Val 
        275                 280                 285             

Arg Leu Arg Leu Trp Leu Thr Arg Gln Gly Leu Trp Asp Asp Glu Arg 
    290                 295                 300                 

Gln Ala Ala Cys Glu Glu Glu Ala Glu Ala Arg Val Arg Gln Ala Val 
305                 310                 315                 320 

Ala Asp Met Glu Ala Tyr Pro His Lys Ser Leu Glu Glu Ala Ala Arg 
                325                 330                 335     

His Val Tyr Ala Glu Val Pro Glu Ala Leu Ala Leu His Leu Ala Lys 
            340                 345                 350         

Arg Gly Lys Glu Ala Arg 
        355             

<210>   895
<211>   358
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 885

<400>   895
Met Asp Asp Val Gln Val Tyr Arg Phe Thr Gly Asp Thr Lys Pro Asp 
                5                   10                  15      

Gln Val Leu Asn Glu Ala Gly Glu Met Val Gly Glu Leu Pro Glu Asn 
            20                  25                  30          

Ala Ala Asp Leu Ala Leu Glu Trp Tyr Pro Phe Met Ile Phe Cys Arg 
        35                  40                  45              

Lys Phe Asp Glu Arg Ala Gln Leu Leu Gln Arg Gln Gly Arg Leu Gly 
    50                  55                  60                  

Thr Tyr Ala Pro Phe Arg Gly Gln Glu Ala Ala Gln Ile Ala Ser Phe 
65                  70                  75                  80  

Ala Val Leu Arg Pro Ser Asp Trp Val Phe Pro Thr Tyr Arg Glu Leu 
                85                  90                  95      

Ala Gly Met Met Tyr His Gly Leu Glu Pro Val His Ala Leu Leu Lys 
            100                 105                 110         

Ser Arg Gly His Pro Asp Ala Gly Arg Met Pro Glu Glu Ile His Met 
        115                 120                 125             

Ala Pro Pro Gln Ile Ala Ile Ala Ala Gln Ile Leu His Ala Val Gly 
    130                 135                 140                 

Ala Gly Trp Ala Cys Lys Leu Gln Glu Lys Asp Asp Ile Ala Val Ala 
145                 150                 155                 160 

Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Gly Met 
                165                 170                 175     

Asn Phe Ala Ser Val Met Arg Leu Pro Val Val Phe Phe Cys Gln Asn 
            180                 185                 190         

Asn Gln Tyr Ala Ile Ser Val Pro Val His Arg Gln Met Ala Ser Pro 
        195                 200                 205             

Thr Ile Ala Gln Lys Ala Ile Ala Tyr Gly Met Glu Gly Leu Arg Val 
    210                 215                 220                 

Asp Gly Asn Asp Ala Phe Ala Val Tyr Gln Ala Met Cys Tyr Ala Val 
225                 230                 235                 240 

Glu Arg Ala Arg Arg Gly Asp Gly Pro Thr Leu Ile Glu Ala Val Thr 
                245                 250                 255     

Tyr Arg Ile Gly Pro His Thr Thr Ala Asp Asp Pro Gly Arg Tyr Arg 
            260                 265                 270         

Asp Ala Val Asp Val Glu Arg Trp Ala Ala Ala Lys Asp Pro Leu Val 
        275                 280                 285             

Arg Leu Arg Leu Trp Leu Thr Arg Gln Gly Leu Trp Asp Asp Glu Arg 
    290                 295                 300                 

Gln Ala Ala Cys Glu Glu Glu Ala Glu Ala Arg Val Arg Gln Ala Val 
305                 310                 315                 320 

Ala Asp Met Glu Ala Tyr Pro His Lys Ser Leu Glu Glu Ala Ala Arg 
                325                 330                 335     

His Val Tyr Ala Glu Val Pro Glu Ala Leu Ala Leu His Leu Ala Lys 
            340                 345                 350         

Arg Gly Lys Glu Ala Arg 
        355             

<210>   896
<211>   358
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 885

<400>   896
Met Asp Asp Val Gln Val Tyr Arg Phe Thr Gly Asp Thr Lys Pro Asp 
                5                   10                  15      

Gln Val Leu Asn Glu Ala Gly Glu Met Val Gly Glu Leu Pro Glu Asn 
            20                  25                  30          

Ala Ala Asp Leu Ala Leu Glu Trp Tyr Pro Phe Met Ile Phe Cys Arg 
        35                  40                  45              

Lys Phe Asp Glu Arg Ala Gln Leu Leu Gln Arg Gln Gly Arg Leu Gly 
    50                  55                  60                  

Thr Tyr Ala Pro Phe Arg Gly Gln Glu Ala Ala Gln Ile Ala Ser Phe 
65                  70                  75                  80  

Ala Val Leu Arg Pro Ser Asp Trp Val Phe Pro Thr Tyr Arg Glu Leu 
                85                  90                  95      

Ala Gly Met Met Tyr His Gly Leu Glu Pro Val His Ala Leu Leu Lys 
            100                 105                 110         

Ser Arg Gly His Pro Asp Ala Gly Lys Met Pro Glu Glu Ile His Met 
        115                 120                 125             

Ala Pro Pro Gln Ile Ala Ile Ala Ala Gln Ile Leu His Ala Val Gly 
    130                 135                 140                 

Ala Gly Trp Ala Cys Lys Leu Gln Glu Lys Asp Asp Ile Ala Val Ala 
145                 150                 155                 160 

Tyr Phe Gly Asp Gly Ala Thr Ser Glu Gly Asp Phe His Glu Gly Met 
                165                 170                 175     

Asn Phe Ala Ser Val Met Arg Leu Pro Val Val Phe Phe Cys Gln Asn 
            180                 185                 190         

Asn Gln Tyr Ala Ile Ser Val Pro Val His Arg Gln Met Ala Ser Pro 
        195                 200                 205             

Thr Ile Ala Gln Lys Ala Ile Ala Tyr Gly Met Glu Gly Leu Arg Val 
    210                 215                 220                 

Asp Gly Asn Asp Ala Phe Ala Val Tyr Gln Ala Met Cys Tyr Ala Val 
225                 230                 235                 240 

Glu Arg Ala Arg Arg Gly Asp Gly Pro Thr Leu Ile Glu Ala Val Thr 
                245                 250                 255     

Tyr Arg Leu Gly Pro His Thr Thr Ala Asp Asp Pro Gly Arg Tyr Arg 
            260                 265                 270         

Asp Ala Val Asp Val Glu Arg Trp Ala Ala Ala Lys Asp Pro Leu Val 
        275                 280                 285             

Arg Leu Arg Leu Trp Leu Thr Arg Gln Gly Leu Trp Asp Asp Glu Arg 
    290                 295                 300                 

Gln Ala Ala Cys Glu Glu Glu Ala Glu Ala Arg Val Arg Gln Ala Val 
305                 310                 315                 320 

Ala Asp Met Glu Ala Tyr Pro His Lys Ser Leu Glu Glu Ala Ala Arg 
                325                 330                 335     

His Val Tyr Ala Glu Val Pro Glu Ala Leu Ala Leu His Leu Ala Lys 
            340                 345                 350         

Arg Gly Lys Glu Ala Arg 
        355             

<210>   897
<211>   1077
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 886

<400>   897
gtggatgacg tgcagattta ccggttcacg ggcgacacaa aaccggatca ggtgctgaat       60

gaggcgggcg agatggtggg cgagttgccc gagaacgcgg ccgatctcgc cctcgagtgg      120

taccctttca tgatcttctg ccgaaaattc gacgagcgcg cgcaactcct gcagcggcag      180

gggcggctcg gaacctacgc gccgtttcgc ggccaggagg cggcgcagat cgccagtttt      240

gccgtgcttc gtccgagcga ttgggtgttt cccacgtacc gcgagctcgc cggcatgatg      300

taccacgggc tggaacctgt gcacgccctg ctcaagagcc gcggacatcc ggacgcaggc      360

cgcatgccgg aagagatcca catggcgcct cctcagatcg ccatcgcggc gcagatttta      420

cacgcggtgg gcgcgggctg ggcgtgcaag ttgcaggaga aggacgacat cgccgtggcg      480

tatttcggtg acggtgcgac gtccgaggga gattttcacg agggcatgaa cttcgcttcc      540

gtcatgcgcc tgcccgtcgt gttcttctgc cagaacaacc agtacgccat cagcgtgccc      600

gtgcatcggc agatggcgtc gccgaccatc gcgcaaaagg ccatcgcgta cggcatggag      660

ggcctcaggg tcgacgggaa cgacgccttc gccgtgtatc aggcgatgtg ctacgccgtc      720

gagcgggcgc gccgtgggga cggcccgacg ctcatcgagg cggtcacgta tcgcctgggt      780

ccgcacacga ccgcggacga tcccggaagg tatcgggacg ccgtggatgt ggagcgatgg      840

gcggcggcca aagacccgct cgtgaggctc aggctctggc ttacgcgaca gggactctgg      900

gacgatgagc ggcaagccgc gtgtgaagag gaggccgaag cgcgcgtgcg ccaggcggtg      960

gccgacatgg aagcgtaccc gcataagtcc ctcgaggagg ccgcgcgcca cgtgtacgcc     1020

gaggtcccgg aggcactcgc gcttcatctc gccaaacgcg gaaaggaggc gcgctga        1077


<210>   898
<211>   1077
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 886

<400>   898
gtggatgacg tgcaggttta ccggttcacg ggcgacacaa aaccggatca ggtgctgaat       60

gaggcgggcg agatggtggg cgagttgccc gagaacgcgg ccgatctcgc cctcgagtgg      120

taccctttca tgatcttctg ccgaaaattc gacgagcgcg cgcaaattct gcagcggcag      180

gggcggctcg gaacctacgc gccgtttcgc ggccaggagg cggcgcagat cgccagtttt      240

gccgtgcttc gtccgagcga ttgggtgttt cccacgtacc gcgagctcgc cggcatgatg      300

taccacgggc tggaacctgt gcacgccctg ctcaagagcc gcggacatcc ggacgcaggc      360

cgcatgccgg aagagatcca catggcgcct cctcagatcg ccatcgcggc gcagatttta      420

cacgcggtgg gcgcgggctg ggcgtgcaag ttgcaggaga aggacgacat cgccgtggcg      480

tatttcggtg acggtgcgac gtccgaggga gattttcacg agggcatgaa cttcgcttcc      540

gtcatgcgcc tgcccgtcgt gttcttctgc cagaacaacc agtacgccat cagcgtgccc      600

gtgcatcggc agatggcgtc gccgaccatc gcgcaaaagg ccatcgcgta cggcatggag      660

ggcctcaggg tcgacgggaa cgacgccttc gccgtgtatc aggcgatgtg ctacgccgtc      720

gagcgggcgc gccgtgggga cggcccgacg ctcatcgagg cggtcacgta tcgcctgggt      780

ccgcacacga ccgcggacga tcccggaagg tatcgggacg ccgtggatgt ggagcgatgg      840

gcggcggcca aagacccgct cgtgaggctc aggctctggc ttacgcgaca gggactctgg      900

gacgatgagc ggcaagccgc gtgtgaagag gaggccgaag cgcgcgtgcg ccaggcggtg      960

gccgacatgg aagcgtaccc gcataagtcc ctcgaggagg ccgcgcgcca cgtgtacgcc     1020

gaggtcccgg aggcactcgc gcttcatctc gccaaacgcg gaaaggaggc gcgctga        1077


<210>   899
<211>   1077
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 886

<400>   899
gtggatgacg tgcaggttta ccggttcacg ggcgacacaa aaccggatca ggtgctgaat       60

gaggcgggcg agatggtggg cgagttgccc gagaacgcgg ccgatctcgc cctcgagtgg      120

taccctttca tgatcttctg ccgacgtttc gacgagcgcg cgcaactcct gcagcggcag      180

gggcggctcg gaacctacgc gccgtttcgc ggccaggagg cggcgcagat cgccagtttt      240

gccgtgcttc gtccgagcga ttgggtgttt cccacgtacc gcgagctcgc cggcatgatg      300

taccacgggc tggaacctgt gcacgccctg ctcaagagcc gcggacatcc ggacgcaggc      360

cgcatgccgg aagagatcca catggcgcct cctcagatcg ccatcgcggc gcagatttta      420

cacgcggtgg gcgcgggctg ggcgtgcaag ttgcaggaga aggacgacat cgccgtggcg      480

tatttcggtg acggtgcgac gtccgaggga gattttcacg agggcatgaa cttcgcttcc      540

gtcatgcgcc tgcccgtcgt gttcttctgc cagaacaacc agtacgccat cagcgtgccc      600

gtgcatcggc agatggcgtc gccgaccatc gcgcaaaagg ccatcgcgta cggcatggag      660

ggcctcaggg tcgacgggaa cgacgccttc gccgtgtatc aggcgatgtg ctacgccgtc      720

gagcgggcgc gccgtgggga cggcccgacg ctcatcgagg cggtcacgta tcgcctgggt      780

ccgcacacga ccgcggacga tcccggaagg tatcgggacg ccgtggatgt ggagcgatgg      840

gcggcggcca aagacccgct cgtgaggctc aggctctggc ttacgcgaca gggactctgg      900

gacgatgagc ggcaagccgc gtgtgaagag gaggccgaag cgcgcgtgcg ccaggcggtg      960

gccgacatgg aagcgtaccc gcataagtcc ctcgaggagg ccgcgcgcca cgtgtacgcc     1020

gaggtcccgg aggcactcgc gcttcatctc gccaaacgcg gaaaggaggc gcgctga        1077


<210>   900
<211>   1077
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 886

<400>   900
gtggatgacg tgcaggttta ccggttcacg ggcgacacaa aaccggatca ggtgctgaat       60

gaggcgggcg agatggtggg cgagttgccc gagaacgcgg ccgatctcgc cctcgagtgg      120

taccctttca tgatcttctg ccgaaaattc gacgagcgcg cgcaactcct gcagcggcag      180

gggcggctcg gaacctacgc gccgtttcgc ggccaggagg cggcgcagat cgccagtttt      240

gccgtgcttc gtccgagcga ttgggtgttt cccacgtacc gcgagctcgc cggcatgatg      300

taccacgggc tggaacctgt gcacgccctg ctcaagagcc gcggacatcc ggacgcaggc      360

cgcatgccgg aagagatcca catggcgcct cctcagatcg ccatcgcggc gcagatttta      420

cacgcggtgg gcgcgggctg ggcgtgcaag ttgcaggaga aggacgacat cgccgtggcg      480

tatttcggtg acggtgcgac gtccgaggga gattttcacg agggcatgaa cttcgcttcc      540

gtcatgcgcc tgcccgtcgt gttcttctgc cagaacaacc agtacgccat cagcgtgccc      600

gtgcatcggc agatggcgtc gccgaccatc gcgcaaaagg ccatcgcgta cggcatggag      660

ggcctcaggg tcgacgggaa cgacgccttc gccgtgtatc aggcgatgtg ctacgccgtc      720

gagcgggcgc gccgtgggga cggcccgacg ctcatcgagg cggtcacgta tcgcattggt      780

ccgcacacga ccgcggacga tcccggaagg tatcgggacg ccgtggatgt ggagcgatgg      840

gcggcggcca aagacccgct cgtgaggctc aggctctggc ttacgcgaca gggactctgg      900

gacgatgagc ggcaagccgc gtgtgaagag gaggccgaag cgcgcgtgcg ccaggcggtg      960

gccgacatgg aagcgtaccc gcataagtcc ctcgaggagg ccgcgcgcca cgtgtacgcc     1020

gaggtcccgg aggcactcgc gcttcatctc gccaaacgcg gaaaggaggc gcgctga        1077


<210>   901
<211>   1077
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 886

<400>   901
gtggatgacg tgcaggttta ccggttcacg ggcgacacaa aaccggatca ggtgctgaat       60

gaggcgggcg agatggtggg cgagttgccc gagaacgcgg ccgatctcgc cctcgagtgg      120

taccctttca tgatcttctg ccgaaaattc gacgagcgcg cgcaactcct gcagcggcag      180

gggcggctcg gaacctacgc gccgtttcgc ggccaggagg cggcgcagat cgccagtttt      240

gccgtgcttc gtccgagcga ttgggtgttt cccacgtacc gcgagctcgc cggcatgatg      300

taccacgggc tggaacctgt gcacgccctg ctcaagagcc gcggacatcc ggacgcaggc      360

aaaatgccgg aagagatcca catggcgcct cctcagatcg ccatcgcggc gcagatttta      420

cacgcggtgg gcgcgggctg ggcgtgcaag ttgcaggaga aggacgacat cgccgtggcg      480

tatttcggtg acggtgcgac gtccgaggga gattttcacg agggcatgaa cttcgcttcc      540

gtcatgcgcc tgcccgtcgt gttcttctgc cagaacaacc agtacgccat cagcgtgccc      600

gtgcatcggc agatggcgtc gccgaccatc gcgcaaaagg ccatcgcgta cggcatggag      660

ggcctcaggg tcgacgggaa cgacgccttc gccgtgtatc aggcgatgtg ctacgccgtc      720

gagcgggcgc gccgtgggga cggcccgacg ctcatcgagg cggtcacgta tcgcctgggt      780

ccgcacacga ccgcggacga tcccggaagg tatcgggacg ccgtggatgt ggagcgatgg      840

gcggcggcca aagacccgct cgtgaggctc aggctctggc ttacgcgaca gggactctgg      900

gacgatgagc ggcaagccgc gtgtgaagag gaggccgaag cgcgcgtgcg ccaggcggtg      960

gccgacatgg aagcgtaccc gcataagtcc ctcgaggagg ccgcgcgcca cgtgtacgcc     1020

gaggtcccgg aggcactcgc gcttcatctc gccaaacgcg gaaaggaggc gcgctga        1077


<210>   902
<211>   325
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   902
Met Pro Lys Trp Thr Met Ile Glu Ala Ile Arg Asp Ala Leu Ala Ile 
                5                   10                  15      

Ala Leu Arg Asp Asp Pro Arg Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Ala Arg Val Ala Asp Thr Pro Leu Ala Glu Lys Ala Ile Val 
    50                  55                  60                  

Gly Thr Ala Val Gly Leu Ala Met Ala Gly Met Lys Pro Val Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Ala Tyr Glu Ala Met Asp Gln Ile Ala Ala 
                85                  90                  95      

Gln Leu Ala Arg Ile Arg Phe Arg Thr Gln Gly Arg Phe Thr Ala Pro 
            100                 105                 110         

Ala Val Ile Arg Ala Pro Tyr Gly Gly Gly Val Arg Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Ala Leu Phe Ala His Thr Pro Gly Leu Val 
    130                 135                 140                 

Val Val Thr Pro Ser Arg Pro Tyr Asp Ala Lys Gly Leu Leu Leu Ser 
145                 150                 155                 160 

Ala Ile Arg Ser Pro Asp Pro Val Val Phe Leu Glu Pro Ile Arg Leu 
                165                 170                 175     

Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Asp Tyr Gln Val Pro 
            180                 185                 190         

Leu Gly Arg Ala Ala Val Arg Arg Glu Gly Ser Asp Val Thr Leu Val 
        195                 200                 205             

Ala Trp Gly Pro Thr Val Pro Val Ala Glu Ser Ala Ala Ala Gln Val 
    210                 215                 220                 

Ala Ser Arg Gly Ile Ser Cys Glu Val Leu Asp Leu Arg Thr Leu Ala 
225                 230                 235                 240 

Pro Leu Asp Arg Ser Ala Leu Lys Ala Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Val Ile Val His Glu Ala Val Arg Tyr Ala Gly Leu Gly Ala Glu 
            260                 265                 270         

Ile Ala Ala Ser Ile Met Asp Leu Ala Phe Tyr His Leu Arg Ala Pro 
        275                 280                 285             

Ile Glu Arg Val Ala Gly Leu Asp Thr Pro Tyr Pro Pro Pro Ala Leu 
    290                 295                 300                 

Glu Asp Ala Trp Leu Pro Ser Val Thr Arg Val Val Glu Ala Ile Glu 
305                 310                 315                 320 

Arg Val Met Glu Asp 
                325 

<210>   903
<211>   978
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   903
atgcccaagt ggacgatgat cgaggccatt cgggatgcgc tggccatcgc ccttcgcgac       60

gatccgcgcg ttctcgtctt cggcgaggac gtagggaaaa acggcggtgt cttccgcgcc      120

acggacgggc tgcaggccga attcggcgaa gcgcgcgtcg ccgacacgcc gctcgcggag      180

aaggccatcg tcggaacggc cgtgggcctc gccatggcgg gcatgaagcc cgtcgccgag      240

atccagtttc tcggctttgc ctacgaggcg atggatcaga tcgccgcgca gctcgcgcgc      300

atccgcttcc gcacgcaggg acggttcacg gcccccgcgg tcattcgtgc cccatacgga      360

ggtggcgtgc gcacgccgga gctgcactcg gacagcctgg aggcgctctt tgcccacacg      420

ccggggctcg tcgtcgtgac gcctagccgt ccgtacgacg ccaaggggct tttgctcagc      480

gccatccgtt cgcccgatcc cgtcgtcttc ctggaaccca tcaggctcta tcgcgccttc      540

cgggaagagg tgcctgaggg agactaccag gtgccgctcg gccgggcggc cgtccgccgc      600

gagggctcgg acgtcacgct cgtcgcctgg gggcccaccg tgccggtggc ggaatcggcg      660

gcagcccagg tggcatcccg ggggatttcg tgcgaggttc tggatctgcg cacgctcgcg      720

ccgctcgacc gatccgccct caaagcgtcc gtggagaaga cgggccgcgc cgtcatcgtc      780

cacgaggcgg tgcggtatgc cgggctcggc gccgagatcg ccgcctccat catggacctg      840

gcgttttacc acctgcgggc gcccatcgag cgggtggccg ggctcgacac gccctacccg      900

ccgcccgcgc tcgaggacgc ctggctcccg agcgtgacgc gcgtcgtcga ggccatcgag      960

cgcgtcatgg aagattga                                                    978


<210>   904
<211>   323
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   904
Met Ala Glu Leu Thr Met Ile Glu Ala Ile Asn Glu Ala Met Arg Gln 
                5                   10                  15      

Glu Met Glu Arg Asp Pro Arg Ile Ile Val Leu Gly Glu Asp Val Gly 
            20                  25                  30          

Glu Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Ala Gln Phe 
        35                  40                  45              

Gly Glu Gly Arg Val Phe Asp Thr Pro Leu Ala Glu Ser Gly Ile Ile 
    50                  55                  60                  

Gly Thr Ser Ile Gly Leu Ala Ile Asn Gly Met Arg Pro Ile Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Val Tyr Gln Ala Met Asp Gln Leu Ala Ala 
                85                  90                  95      

Gln Ala Ala Arg Ile Arg Phe Arg Ser Ala Gly Arg Phe Ser Cys Pro 
            100                 105                 110         

Ile Val Val Arg Ser Pro Tyr Gly Gly Gly Val Arg Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ala Leu Glu Ala Leu Phe Thr His Ser Pro Gly Leu Lys 
    130                 135                 140                 

Val Val Met Pro Ser Asn Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Arg Asp Glu Asp Pro Val Leu Phe Leu Glu Pro Met Lys Leu 
                165                 170                 175     

Tyr Arg Ala Phe Arg Met Glu Val Pro Glu Glu Pro Tyr Thr Ile Pro 
            180                 185                 190         

Leu Gly Gln Ala Arg Val Val Lys Glu Gly Asp Asp Val Thr Ile Ile 
        195                 200                 205             

Ala Trp Gly Ala Thr Val Pro Leu Ala Ala Lys Val Ala Ala Glu Met 
    210                 215                 220                 

Gln Ala Lys Gly Val Asn Ala Glu Val Ile Asp Leu Arg Cys Leu Gln 
225                 230                 235                 240 

Pro Leu Asp Ile Asp Thr Ile Ile Thr Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Val Met Ile Val His Glu Ala Val Lys Thr Gly Gly Phe Gly Ala Glu 
            260                 265                 270         

Val Ala Ala Leu Ile Ser Glu Arg Ala Leu Phe Ser Leu Ser Ala Pro 
        275                 280                 285             

Ile Val Arg Ile Ala Gly Tyr Asp Thr Pro Tyr Pro Val Pro Ser Val 
    290                 295                 300                 

Glu Asp Asp Trp Leu Pro Asn Ala Glu Arg Ile Ala Glu Gly Ile Glu 
305                 310                 315                 320 

Thr Leu Leu 
            

<210>   905
<211>   323
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   905
Met Ala Glu Leu Thr Met Ile Glu Ala Ile Asn Glu Ala Met Arg Gln 
                5                   10                  15      

Glu Met Glu Arg Asn Ser Arg Val Ile Val Leu Gly Glu Asp Val Gly 
            20                  25                  30          

Glu Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Leu Glu Gln Phe 
        35                  40                  45              

Gly Ser Gly Arg Val Phe Asp Thr Pro Leu Ala Glu Ser Gly Ile Ile 
    50                  55                  60                  

Gly Thr Ser Ile Gly Leu Ala Ile Asn Gly Met Arg Pro Ile Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Val Tyr Gln Ala Met Asp Gln Leu Ala Ala 
                85                  90                  95      

Gln Ala Ala Arg Ile Arg Phe Arg Ser Gly Gly Arg Phe Ser Cys Pro 
            100                 105                 110         

Ile Val Val Arg Ser Pro Tyr Gly Gly Gly Val Arg Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ala Leu Glu Ala Leu Phe Thr His Ser Pro Gly Leu Lys 
    130                 135                 140                 

Val Val Met Pro Ser Asn Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Arg Asp Asp Asp Pro Val Leu Phe Phe Glu Pro Met Lys Leu 
                165                 170                 175     

Tyr Arg Ala Phe Arg Met Glu Val Pro Glu Glu Pro Tyr Thr Ile Pro 
            180                 185                 190         

Leu Gly Gln Ala Arg Ile Val Lys Glu Gly Asp Asp Val Thr Ile Leu 
        195                 200                 205             

Thr Trp Gly Ala Thr Val Pro Leu Val Ala Lys Leu Ala Asp Glu Met 
    210                 215                 220                 

Arg Met Arg Gly Val Asp Ala Glu Val Ile Asp Leu Arg Cys Leu Gln 
225                 230                 235                 240 

Pro Leu Asp Ile Asp Thr Ile Ile Ala Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Val Met Ile Val His Glu Ala Val Lys Thr Ser Gly Phe Gly Ala Glu 
            260                 265                 270         

Val Ala Ala Leu Ile Ser Glu Arg Ala Leu Phe Ser Leu Ser Ala Pro 
        275                 280                 285             

Ile Val Arg Ile Ala Gly Tyr Asp Thr Pro Tyr Pro Val Pro Ser Val 
    290                 295                 300                 

Glu Asp Asp Trp Leu Pro Asn Pro Ala Arg Ile Val Glu Gly Ile Glu 
305                 310                 315                 320 

Thr Leu Met 
            

<210>   906
<211>   320
<212>   PRT
<213>   Exiguobacterium sibiricum 255-15

<400>   906
Thr Leu Val Gln Ala Val Thr Asp Ala Leu Arg Thr Lys Leu Thr Asp 
                5                   10                  15      

Asp Glu Thr Thr Leu Val Leu Gly Glu Asp Val Gly Lys Asn Gly Gly 
            20                  25                  30          

Val Phe Arg Ala Thr Asp Gly Leu Gln Glu Glu Phe Gly Glu Asp Arg 
        35                  40                  45              

Ile Ile Asp Thr Pro Leu Ser Glu Ala Gly Ile Val Gly Thr Ser Ile 
    50                  55                  60                  

Gly Leu Ala Val Asn Gly Phe Lys Pro Ile Val Glu Ile Gln Phe Leu 
65                  70                  75                  80  

Gly Phe Ile Tyr Pro Ala Tyr Glu Gln Ile Met Thr His Val Ser Arg 
                85                  90                  95      

Ile Arg Met Arg Thr Met Gly Arg Tyr Gly Val Pro Met Val Ile Arg 
            100                 105                 110         

Ala Pro Tyr Gly Ala Gly Ile Arg Ala Pro Glu Ile His Ser Asp Ser 
        115                 120                 125             

Thr Glu Ala Leu Phe Thr Ser Met Pro Gly Leu Lys Val Val Cys Pro 
    130                 135                 140                 

Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ala Ala Ile Glu Asp 
145                 150                 155                 160 

Pro Asp Pro Val Leu Phe Leu Glu Ser Met Arg Ser Tyr Arg Ala Phe 
                165                 170                 175     

Lys Glu Pro Val Pro Ser Glu Ala Tyr Thr Ile Glu Ile Gly Lys Ala 
            180                 185                 190         

Asn Cys Ile Thr Glu Gly Gln Asp Val Thr Leu Ile Ala Trp Gly Ala 
        195                 200                 205             

Met Val Gln Val Ala Gln Lys Ala Ala Thr Glu Ala Ala Thr Arg Gly 
    210                 215                 220                 

Ile Ser Cys Glu Val Ile Asp Leu Arg Thr Leu Tyr Pro Leu Asp Arg 
225                 230                 235                 240 

Glu Thr Ile Ser Ala Ser Val Gln Lys Thr Gly Arg Ala Val Ile Ile 
                245                 250                 255     

His Glu Ala Gln Ala Thr Gly Gly Leu Gly Asn Asp Leu Leu Ala Leu 
            260                 265                 270         

Ile Asn Asp Thr Ser Phe Leu Tyr Leu Arg Ala Pro Val Ala Arg Val 
        275                 280                 285             

Thr Gly Phe Asp Val Pro Val Pro Leu Phe Ala Leu Glu Asp His Tyr 
    290                 295                 300                 

Ile Pro Thr Pro Thr Arg Val Leu Glu Ala Ile Gln Arg Thr Val Asp 
305                 310                 315                 320 

<210>   907
<211>   323
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   907
Met Ala Gln Met Thr Met Val Gln Ala Ile Thr Asp Ala Leu Arg Ile 
                5                   10                  15      

Glu Leu Lys Asn Asp Pro Asn Val Leu Ile Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Val Asn Gly Gly Val Phe Arg Ala Thr Glu Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Glu Arg Val Phe Asp Thr Pro Leu Ala Glu Ser Gly Ile Gly 
    50                  55                  60                  

Gly Leu Ala Val Gly Leu Ala Leu Gln Gly Phe Arg Pro Val Pro Glu 
65                  70                  75                  80  

Ile Gln Phe Phe Gly Phe Val Tyr Glu Val Met Asp Ser Ile Ser Gly 
                85                  90                  95      

Gln Met Ala Arg Ile Arg Tyr Arg Thr Gly Gly Arg Tyr His Met Pro 
            100                 105                 110         

Ile Thr Val Arg Ser Pro Phe Gly Gly Gly Val His Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Gly Leu Val Ala Gln Gln Pro Gly Leu Lys 
    130                 135                 140                 

Val Val Ile Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Arg Asp Asn Asp Pro Val Ile Phe Leu Glu His Leu Lys Leu 
                165                 170                 175     

Tyr Arg Ser Phe Arg Gln Glu Val Pro Glu Gly Glu Tyr Thr Ile Pro 
            180                 185                 190         

Ile Gly Lys Ala Asp Ile Lys Arg Glu Gly Lys Asp Ile Thr Ile Ile 
        195                 200                 205             

Ala Tyr Gly Ala Met Val His Glu Ser Leu Lys Ala Ala Ala Glu Leu 
    210                 215                 220                 

Glu Lys Glu Gly Ile Ser Ala Glu Val Val Asp Leu Arg Thr Val Gln 
225                 230                 235                 240 

Pro Leu Asp Ile Glu Thr Ile Ile Gly Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Ile Val Val Gln Glu Ala Gln Arg Gln Ala Gly Ile Ala Ala Asn 
            260                 265                 270         

Val Val Ala Glu Ile Asn Glu Arg Ala Ile Leu Ser Leu Glu Ala Pro 
        275                 280                 285             

Val Leu Arg Val Ala Ala Pro Asp Thr Val Tyr Pro Phe Ala Gln Ala 
    290                 295                 300                 

Glu Ser Val Trp Leu Pro Asn Phe Lys Asp Val Ile Glu Thr Ala Lys 
305                 310                 315                 320 

Lys Val Met 
            

<210>   908
<211>   323
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   908
Met Ala Gln Met Thr Met Ile Gln Ala Ile Thr Asp Ala Leu Arg Val 
                5                   10                  15      

Glu Met Lys Asn Asp Pro Asn Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Val Asn Gly Gly Val Phe Arg Ala Thr Glu Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Asp Arg Val Met Asp Thr Pro Leu Ala Glu Ser Gly Ile Gly 
    50                  55                  60                  

Gly Leu Ala Val Gly Leu Ala Leu Glu Gly Phe Arg Pro Val Pro Glu 
65                  70                  75                  80  

Ile Gln Phe Phe Gly Phe Val Tyr Glu Val Met Asp Ser Ile Ser Gly 
                85                  90                  95      

Gln Leu Ala Arg Met Arg Tyr Arg Ser Gly Gly Arg Trp Thr Ala Pro 
            100                 105                 110         

Val Thr Val Arg Ser Pro Phe Gly Gly Gly Val His Thr Pro Glu Leu 
        115                 120                 125             

His Ala Asp Ser Leu Glu Gly Leu Val Ala Gln Gln Pro Gly Leu Lys 
    130                 135                 140                 

Val Val Ile Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Arg Asp Asn Asp Pro Val Ile Tyr Leu Glu His Met Lys Leu 
                165                 170                 175     

Tyr Arg Ser Phe Arg Gln Glu Val Pro Glu Gly Asp Tyr Thr Ile Asp 
            180                 185                 190         

Leu Gly Lys Ala Asp Ile Lys Arg Glu Gly Thr Asp Val Ser Val Ile 
        195                 200                 205             

Ala Tyr Gly Ala Met Val His Ala Ala Leu Lys Ala Ala Glu Glu Leu 
    210                 215                 220                 

Glu Lys Glu Gly Ile Ser Leu Glu Val Val Asp Leu Arg Thr Val Gln 
225                 230                 235                 240 

Pro Leu Asp Ile Glu Thr Ile Ile Ala Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Val Val Val Val Gln Glu Ala Gln Lys Gln Ala Gly Ile Ala Ala Asn 
            260                 265                 270         

Val Val Ala Glu Ile Asn Asp Arg Ala Ile Leu Asn Leu Glu Ala Pro 
        275                 280                 285             

Val Val Arg Val Ala Ala Ala Asp Thr Val Phe Pro Phe Ser Gln Ala 
    290                 295                 300                 

Glu Ser Val Trp Leu Pro Asn His Lys Asp Ile Val Glu Ala Val Asn 
305                 310                 315                 320 

Lys Val Met 
            

<210>   909
<211>   325
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 902

<400>   909
Met Pro Lys Trp Thr Met Ile Glu Ala Ile Arg Asp Ala Leu Ala Ile 
                5                   10                  15      

Ala Leu Arg Asp Asp Pro Arg Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Ala Arg Val Ala Asp Thr Pro Leu Ala Glu Lys Ala Ile Val 
    50                  55                  60                  

Gly Thr Ala Val Gly Leu Ala Met Ala Gly Met Lys Pro Val Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Ala Tyr Glu Ala Met Asp Gln Ile Ala Ala 
                85                  90                  95      

Gln Leu Ala Arg Ile Arg Phe Arg Thr Gln Gly Arg Phe Thr Ala Pro 
            100                 105                 110         

Ala Val Ile Arg Ala Pro Tyr Gly Gly Gly Val Arg Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Ala Leu Phe Ala His Thr Pro Gly Leu Val 
    130                 135                 140                 

Val Val Thr Pro Ser Arg Pro Tyr Asp Ala Lys Gly Leu Leu Leu Ser 
145                 150                 155                 160 

Ala Ile Arg Ser Pro Asp Pro Val Val Phe Leu Glu Pro Ile Arg Leu 
                165                 170                 175     

Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Asp Tyr Gln Val Pro 
            180                 185                 190         

Leu Gly Arg Ala Ala Val Arg Arg Glu Gly Ser Asp Val Thr Leu Val 
        195                 200                 205             

Ala Trp Gly Pro Thr Val Pro Val Ala Glu Ser Ala Ala Ala Gln Val 
    210                 215                 220                 

Ala Ser Arg Gly Ile Ser Cys Glu Val Leu Asp Leu Arg Thr Leu Ala 
225                 230                 235                 240 

Pro Leu Asp Arg Ser Ala Leu Lys Ala Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Val Ile Val His Glu Ala Val Arg Tyr Ala Gly Leu Gly Ala Glu 
            260                 265                 270         

Ile Ala Ala Ser Ile Met Asp Leu Ala Phe Tyr His Leu Arg Ala Pro 
        275                 280                 285             

Ile Glu Arg Val Ala Gly Leu Asp Thr Pro Tyr Pro Pro Pro Ala Leu 
    290                 295                 300                 

Glu Asp Ala Trp Leu Pro Ser Val Thr Arg Val Val Glu Ala Ile Glu 
305                 310                 315                 320 

Arg Val Met Glu Glu 
                325 

<210>   910
<211>   325
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 902

<400>   910
Met Pro Lys Trp Thr Met Ile Glu Ala Ile Arg Asp Ala Leu Ala Ile 
                5                   10                  15      

Ala Leu Arg Asp Asp Pro Arg Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Ala Arg Val Ala Asp Thr Pro Leu Ala Glu Lys Ala Ile Val 
    50                  55                  60                  

Gly Thr Ala Val Gly Leu Ala Met Ala Gly Met Lys Pro Val Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Ala Tyr Glu Ala Met Asp Gln Ile Ala Ala 
                85                  90                  95      

Gln Leu Ala Arg Ile Arg Phe Arg Thr Gln Gly Arg Phe Thr Ala Pro 
            100                 105                 110         

Ala Val Ile Arg Ala Pro Tyr Gly Gly Gly Val Arg Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Ala Leu Phe Ala His Thr Pro Gly Leu Val 
    130                 135                 140                 

Val Val Thr Pro Ser Arg Pro Tyr Asp Ala Lys Gly Leu Leu Leu Ser 
145                 150                 155                 160 

Ala Ile Arg Ser Pro Asp Pro Val Val Phe Leu Glu Pro Ile Arg Leu 
                165                 170                 175     

Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Asp Tyr Gln Val Pro 
            180                 185                 190         

Leu Gly Arg Ala Ala Val Arg Arg Glu Gly Ser Asp Val Thr Leu Val 
        195                 200                 205             

Ala Trp Gly Pro Thr Val Pro Val Ala Glu Ser Ala Ala Ala Gln Val 
    210                 215                 220                 

Ala Ser Arg Gly Ile Ser Cys Glu Val Leu Asp Leu Arg Thr Leu Ala 
225                 230                 235                 240 

Pro Leu Asp Arg Ser Ala Leu Lys Ala Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Val Ile Val His Glu Ala Val Lys Tyr Ala Gly Leu Gly Ala Glu 
            260                 265                 270         

Ile Ala Ala Ser Ile Met Asp Leu Ala Phe Tyr His Leu Arg Ala Pro 
        275                 280                 285             

Ile Glu Arg Val Ala Gly Leu Asp Thr Pro Tyr Pro Pro Pro Ala Leu 
    290                 295                 300                 

Glu Asp Ala Trp Leu Pro Ser Val Thr Arg Val Val Glu Ala Ile Glu 
305                 310                 315                 320 

Arg Val Met Glu Asp 
                325 

<210>   911
<211>   325
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 902

<400>   911
Met Pro Lys Trp Thr Met Ile Glu Ala Ile Arg Asp Ala Leu Ala Ile 
                5                   10                  15      

Ala Leu Arg Asp Asp Pro Arg Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Ala Arg Val Ala Asp Thr Pro Leu Ala Glu Lys Ala Ile Val 
    50                  55                  60                  

Gly Thr Ala Val Gly Leu Ala Met Ala Gly Met Lys Pro Val Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Ala Tyr Glu Ala Met Asp Gln Ile Ala Ala 
                85                  90                  95      

Gln Leu Ala Arg Ile Arg Phe Arg Thr Gln Gly Arg Phe Thr Ala Pro 
            100                 105                 110         

Ala Val Ile Arg Ala Pro Tyr Gly Gly Gly Val Arg Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Ala Leu Phe Ala His Thr Pro Gly Leu Val 
    130                 135                 140                 

Val Val Thr Pro Ser Arg Pro Tyr Asp Ala Lys Gly Leu Leu Leu Ser 
145                 150                 155                 160 

Ala Ile Arg Ser Pro Asp Pro Val Val Phe Leu Glu Pro Ile Arg Leu 
                165                 170                 175     

Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Asp Tyr Gln Val Pro 
            180                 185                 190         

Leu Gly Arg Ala Ala Val Arg Arg Glu Gly Ser Asp Val Thr Leu Val 
        195                 200                 205             

Ala Trp Gly Pro Thr Val Pro Val Ala Glu Ser Ala Ala Ala Gln Val 
    210                 215                 220                 

Ala Ser Arg Gly Ile Ser Cys Glu Val Leu Asp Leu Arg Thr Leu Ala 
225                 230                 235                 240 

Pro Leu Asp Arg Ser Ala Leu Lys Ala Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Val Ile Val His Glu Ala Val Arg Tyr Ala Gly Leu Gly Ala Glu 
            260                 265                 270         

Ile Ala Ala Ser Ile Met Asp Leu Ala Phe Tyr His Leu Arg Ala Pro 
        275                 280                 285             

Ile Glu Arg Val Ala Gly Leu Asp Thr Pro Tyr Pro Pro Pro Ala Leu 
    290                 295                 300                 

Glu Asp Ala Trp Leu Pro Ser Val Thr Arg Val Val Glu Ala Ile Glu 
305                 310                 315                 320 

Lys Val Met Glu Asp 
                325 

<210>   912
<211>   325
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 902

<400>   912
Met Pro Lys Trp Thr Met Ile Glu Ala Ile Arg Asp Ala Leu Ala Ile 
                5                   10                  15      

Ala Leu Arg Asp Asp Pro Arg Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Ala Arg Val Ala Asp Thr Pro Leu Ala Glu Lys Ala Ile Val 
    50                  55                  60                  

Gly Thr Ala Val Gly Leu Ala Met Ala Gly Met Lys Pro Val Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Ala Tyr Glu Ala Met Asp Gln Ile Ala Ala 
                85                  90                  95      

Gln Leu Ala Arg Ile Arg Phe Arg Thr Gln Gly Arg Phe Thr Ala Pro 
            100                 105                 110         

Ala Val Ile Arg Ala Pro Tyr Gly Gly Gly Val Arg Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Ala Leu Phe Ala His Thr Pro Gly Leu Val 
    130                 135                 140                 

Val Val Thr Pro Ser Arg Pro Tyr Asp Ala Lys Gly Leu Leu Leu Ser 
145                 150                 155                 160 

Ala Ile Arg Ser Pro Asp Pro Val Val Phe Leu Glu Pro Ile Arg Leu 
                165                 170                 175     

Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Asp Tyr Gln Val Pro 
            180                 185                 190         

Leu Gly Arg Ala Ala Val Arg Arg Glu Gly Ser Asp Val Thr Leu Val 
        195                 200                 205             

Ala Trp Gly Pro Thr Val Pro Val Ala Glu Ser Ala Ala Ala Gln Val 
    210                 215                 220                 

Ala Ser Arg Gly Ile Ser Cys Glu Val Leu Asp Leu Arg Thr Leu Ala 
225                 230                 235                 240 

Pro Leu Asp Arg Ser Ala Leu Lys Ala Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Val Ile Val His Glu Ala Val Arg Tyr Ala Gly Leu Gly Ala Glu 
            260                 265                 270         

Ile Ala Ala Ser Ile Met Asp Leu Ala Phe Tyr His Leu Arg Ala Pro 
        275                 280                 285             

Ile Glu Arg Val Ala Gly Leu Asp Thr Pro Tyr Pro Pro Pro Ala Leu 
    290                 295                 300                 

Glu Asp Ala Trp Leu Pro Ser Val Thr Arg Val Val Glu Ala Ile Glu 
305                 310                 315                 320 

Arg Val Met Asp Asp 
                325 

<210>   913
<211>   325
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 902

<400>   913
Met Pro Lys Trp Thr Met Ile Glu Ala Ile Arg Asp Ala Leu Ala Ile 
                5                   10                  15      

Ala Leu Lys Asp Asp Pro Arg Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Lys Asn Gly Gly Val Phe Arg Ala Thr Asp Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Ala Arg Val Ala Asp Thr Pro Leu Ala Glu Lys Ala Ile Val 
    50                  55                  60                  

Gly Thr Ala Val Gly Leu Ala Met Ala Gly Met Lys Pro Val Ala Glu 
65                  70                  75                  80  

Ile Gln Phe Leu Gly Phe Ala Tyr Glu Ala Met Asp Gln Ile Ala Ala 
                85                  90                  95      

Gln Leu Ala Arg Ile Arg Phe Arg Thr Gln Gly Arg Phe Thr Ala Pro 
            100                 105                 110         

Ala Val Ile Arg Ala Pro Tyr Gly Gly Gly Val Arg Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Ala Leu Phe Ala His Thr Pro Gly Leu Val 
    130                 135                 140                 

Val Val Thr Pro Ser Arg Pro Tyr Asp Ala Lys Gly Leu Leu Leu Ser 
145                 150                 155                 160 

Ala Ile Arg Ser Pro Asp Pro Val Val Phe Leu Glu Pro Ile Arg Leu 
                165                 170                 175     

Tyr Arg Ala Phe Arg Glu Glu Val Pro Glu Gly Asp Tyr Gln Val Pro 
            180                 185                 190         

Leu Gly Arg Ala Ala Val Arg Arg Glu Gly Ser Asp Val Thr Leu Val 
        195                 200                 205             

Ala Trp Gly Pro Thr Val Pro Val Ala Glu Ser Ala Ala Ala Gln Val 
    210                 215                 220                 

Ala Ser Arg Gly Ile Ser Cys Glu Val Leu Asp Leu Arg Thr Leu Ala 
225                 230                 235                 240 

Pro Leu Asp Arg Ser Ala Leu Lys Ala Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Val Ile Val His Glu Ala Val Arg Tyr Ala Gly Leu Gly Ala Glu 
            260                 265                 270         

Ile Ala Ala Ser Ile Met Asp Leu Ala Phe Tyr His Leu Arg Ala Pro 
        275                 280                 285             

Ile Glu Arg Val Ala Gly Leu Asp Thr Pro Tyr Pro Pro Pro Ala Leu 
    290                 295                 300                 

Glu Asp Ala Trp Leu Pro Ser Val Thr Arg Val Val Glu Ala Ile Glu 
305                 310                 315                 320 

Arg Val Met Glu Asp 
                325 

<210>   914
<211>   978
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 903

<400>   914
atgcccaagt ggacgatgat cgaggccatt cgggatgcgc tggccatcgc ccttcgcgac       60

gatccgcgcg ttctcgtctt cggcgaggac gtagggaaaa acggcggtgt cttccgcgcc      120

acggacgggc tgcaggccga attcggcgaa gcgcgcgtcg ccgacacgcc gctcgcggag      180

aaggccatcg tcggaacggc cgtgggcctc gccatggcgg gcatgaagcc cgtcgccgag      240

atccagtttc tcggctttgc ctacgaggcg atggatcaga tcgccgcgca gctcgcgcgc      300

atccgcttcc gcacgcaggg acggttcacg gcccccgcgg tcattcgtgc cccatacgga      360

ggtggcgtgc gcacgccgga gctgcactcg gacagcctgg aggcgctctt tgcccacacg      420

ccggggctcg tcgtcgtgac gcctagccgt ccgtacgacg ccaaggggct tttgctcagc      480

gccatccgtt cgcccgatcc cgtcgtcttc ctggaaccca tcaggctcta tcgcgccttc      540

cgggaagagg tgcctgaggg agactaccag gtgccgctcg gccgggcggc cgtccgccgc      600

gagggctcgg acgtcacgct cgtcgcctgg gggcccaccg tgccggtggc ggaatcggcg      660

gcagcccagg tggcatcccg ggggatttcg tgcgaggttc tggatctgcg cacgctcgcg      720

ccgctcgacc gatccgccct caaagcgtcc gtggagaaga cgggccgcgc cgtcatcgtc      780

cacgaggcgg tgcggtatgc cgggctcggc gccgagatcg ccgcctccat catggacctg      840

gcgttttacc acctgcgggc gcccatcgag cgggtggccg ggctcgacac gccctacccg      900

ccgcccgcgc tcgaggacgc ctggctcccg agcgtgacgc gcgtcgtcga ggccatcgag      960

cgcgtcatgg aagaatga                                                    978


<210>   915
<211>   978
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 903

<400>   915
atgcccaagt ggacgatgat cgaggccatt cgggatgcgc tggccatcgc ccttcgcgac       60

gatccgcgcg ttctcgtctt cggcgaggac gtagggaaaa acggcggtgt cttccgcgcc      120

acggacgggc tgcaggccga attcggcgaa gcgcgcgtcg ccgacacgcc gctcgcggag      180

aaggccatcg tcggaacggc cgtgggcctc gccatggcgg gcatgaagcc cgtcgccgag      240

atccagtttc tcggctttgc ctacgaggcg atggatcaga tcgccgcgca gctcgcgcgc      300

atccgcttcc gcacgcaggg acggttcacg gcccccgcgg tcattcgtgc cccatacgga      360

ggtggcgtgc gcacgccgga gctgcactcg gacagcctgg aggcgctctt tgcccacacg      420

ccggggctcg tcgtcgtgac gcctagccgt ccgtacgacg ccaaggggct tttgctcagc      480

gccatccgtt cgcccgatcc cgtcgtcttc ctggaaccca tcaggctcta tcgcgccttc      540

cgggaagagg tgcctgaggg agactaccag gtgccgctcg gccgggcggc cgtccgccgc      600

gagggctcgg acgtcacgct cgtcgcctgg gggcccaccg tgccggtggc ggaatcggcg      660

gcagcccagg tggcatcccg ggggatttcg tgcgaggttc tggatctgcg cacgctcgcg      720

ccgctcgacc gatccgccct caaagcgtcc gtggagaaga cgggccgcgc cgtcatcgtc      780

cacgaggcgg tgaaatatgc cgggctcggc gccgagatcg ccgcctccat catggacctg      840

gcgttttacc acctgcgggc gcccatcgag cgggtggccg ggctcgacac gccctacccg      900

ccgcccgcgc tcgaggacgc ctggctcccg agcgtgacgc gcgtcgtcga ggccatcgag      960

cgcgtcatgg aagattga                                                    978


<210>   916
<211>   978
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 903

<400>   916
atgcccaagt ggacgatgat cgaggccatt cgggatgcgc tggccatcgc ccttcgcgac       60

gatccgcgcg ttctcgtctt cggcgaggac gtagggaaaa acggcggtgt cttccgcgcc      120

acggacgggc tgcaggccga attcggcgaa gcgcgcgtcg ccgacacgcc gctcgcggag      180

aaggccatcg tcggaacggc cgtgggcctc gccatggcgg gcatgaagcc cgtcgccgag      240

atccagtttc tcggctttgc ctacgaggcg atggatcaga tcgccgcgca gctcgcgcgc      300

atccgcttcc gcacgcaggg acggttcacg gcccccgcgg tcattcgtgc cccatacgga      360

ggtggcgtgc gcacgccgga gctgcactcg gacagcctgg aggcgctctt tgcccacacg      420

ccggggctcg tcgtcgtgac gcctagccgt ccgtacgacg ccaaggggct tttgctcagc      480

gccatccgtt cgcccgatcc cgtcgtcttc ctggaaccca tcaggctcta tcgcgccttc      540

cgggaagagg tgcctgaggg agactaccag gtgccgctcg gccgggcggc cgtccgccgc      600

gagggctcgg acgtcacgct cgtcgcctgg gggcccaccg tgccggtggc ggaatcggcg      660

gcagcccagg tggcatcccg ggggatttcg tgcgaggttc tggatctgcg cacgctcgcg      720

ccgctcgacc gatccgccct caaagcgtcc gtggagaaga cgggccgcgc cgtcatcgtc      780

cacgaggcgg tgcggtatgc cgggctcggc gccgagatcg ccgcctccat catggacctg      840

gcgttttacc acctgcgggc gcccatcgag cgggtggccg ggctcgacac gccctacccg      900

ccgcccgcgc tcgaggacgc ctggctcccg agcgtgacgc gcgtcgtcga ggccatcgag      960

aaagtcatgg aagattga                                                    978


<210>   917
<211>   978
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 903

<400>   917
atgcccaagt ggacgatgat cgaggccatt cgggatgcgc tggccatcgc ccttcgcgac       60

gatccgcgcg ttctcgtctt cggcgaggac gtagggaaaa acggcggtgt cttccgcgcc      120

acggacgggc tgcaggccga attcggcgaa gcgcgcgtcg ccgacacgcc gctcgcggag      180

aaggccatcg tcggaacggc cgtgggcctc gccatggcgg gcatgaagcc cgtcgccgag      240

atccagtttc tcggctttgc ctacgaggcg atggatcaga tcgccgcgca gctcgcgcgc      300

atccgcttcc gcacgcaggg acggttcacg gcccccgcgg tcattcgtgc cccatacgga      360

ggtggcgtgc gcacgccgga gctgcactcg gacagcctgg aggcgctctt tgcccacacg      420

ccggggctcg tcgtcgtgac gcctagccgt ccgtacgacg ccaaggggct tttgctcagc      480

gccatccgtt cgcccgatcc cgtcgtcttc ctggaaccca tcaggctcta tcgcgccttc      540

cgggaagagg tgcctgaggg agactaccag gtgccgctcg gccgggcggc cgtccgccgc      600

gagggctcgg acgtcacgct cgtcgcctgg gggcccaccg tgccggtggc ggaatcggcg      660

gcagcccagg tggcatcccg ggggatttcg tgcgaggttc tggatctgcg cacgctcgcg      720

ccgctcgacc gatccgccct caaagcgtcc gtggagaaga cgggccgcgc cgtcatcgtc      780

cacgaggcgg tgcggtatgc cgggctcggc gccgagatcg ccgcctccat catggacctg      840

gcgttttacc acctgcgggc gcccatcgag cgggtggccg ggctcgacac gccctacccg      900

ccgcccgcgc tcgaggacgc ctggctcccg agcgtgacgc gcgtcgtcga ggccatcgag      960

cgcgtcatgg atgattga                                                    978


<210>   918
<211>   978
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 903

<400>   918
atgcccaagt ggacgatgat cgaggccatt cgggatgcgc tggccatcgc ccttaaagac       60

gatccgcgcg ttctcgtctt cggcgaggac gtagggaaaa acggcggtgt cttccgcgcc      120

acggacgggc tgcaggccga attcggcgaa gcgcgcgtcg ccgacacgcc gctcgcggag      180

aaggccatcg tcggaacggc cgtgggcctc gccatggcgg gcatgaagcc cgtcgccgag      240

atccagtttc tcggctttgc ctacgaggcg atggatcaga tcgccgcgca gctcgcgcgc      300

atccgcttcc gcacgcaggg acggttcacg gcccccgcgg tcattcgtgc cccatacgga      360

ggtggcgtgc gcacgccgga gctgcactcg gacagcctgg aggcgctctt tgcccacacg      420

ccggggctcg tcgtcgtgac gcctagccgt ccgtacgacg ccaaggggct tttgctcagc      480

gccatccgtt cgcccgatcc cgtcgtcttc ctggaaccca tcaggctcta tcgcgccttc      540

cgggaagagg tgcctgaggg agactaccag gtgccgctcg gccgggcggc cgtccgccgc      600

gagggctcgg acgtcacgct cgtcgcctgg gggcccaccg tgccggtggc ggaatcggcg      660

gcagcccagg tggcatcccg ggggatttcg tgcgaggttc tggatctgcg cacgctcgcg      720

ccgctcgacc gatccgccct caaagcgtcc gtggagaaga cgggccgcgc cgtcatcgtc      780

cacgaggcgg tgcggtatgc cgggctcggc gccgagatcg ccgcctccat catggacctg      840

gcgttttacc acctgcgggc gcccatcgag cgggtggccg ggctcgacac gccctacccg      900

ccgcccgcgc tcgaggacgc ctggctcccg agcgtgacgc gcgtcgtcga ggccatcgag      960

cgcgtcatgg aagattga                                                    978


<210>   919
<211>   391
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   919
Met Lys Arg Met Asn Ile Gly Asn Glu Ala Gln Phe Gln Ile Tyr Gln 
                5                   10                  15      

Met Arg Leu Thr Gly Gln Tyr Gly Gly Asp Pro Leu Cys Ile Ser Met 
            20                  25                  30          

Glu Asp Trp Val Ala Arg Ala Arg Glu Val Leu Ser Pro Glu Ala Phe 
        35                  40                  45              

Trp Tyr Leu Ala Gly Gly Ser Gly Arg Gly Glu Thr Met Arg Ala Asn 
    50                  55                  60                  

Glu Glu Ala Phe Ala Lys Trp Arg Ile Val Pro Arg Val Phe Arg Asp 
65                  70                  75                  80  

Val Ser Val Arg Asp Leu Ser Ile Glu Leu Phe Gly Glu Arg Leu Pro 
                85                  90                  95      

Tyr Pro Val Leu Leu Ala Pro Ile Gly Val Gln Ser Ile Leu His Ala 
            100                 105                 110         

Asp Gly Glu Val Ala Ala Val Arg Gly Ala Ala Lys Val Gly Leu Pro 
        115                 120                 125             

Tyr Ile Val Ser Ser Ala Ser Thr Met Pro Leu Glu Thr Ile Ala Glu 
    130                 135                 140                 

Lys Ala Pro Gly Ala Thr Leu Trp Phe Gln Leu Tyr Trp Ser Arg Asp 
145                 150                 155                 160 

Arg Asp Val Ala Gln Ser Phe Val Arg Arg Ala Glu Ala Ala Gly Cys 
                165                 170                 175     

Lys Ala Leu Val Val Thr Leu Asp Thr Pro Met Met Ala Trp Arg Glu 
            180                 185                 190         

Arg Asp Leu Glu Arg Ala Tyr Leu Pro Phe Leu Leu Gly Glu Gly Leu 
        195                 200                 205             

Gly Asn Tyr Leu Ser Asp Pro Ala Phe Arg Ala Lys Leu Arg Arg Pro 
    210                 215                 220                 

Pro Glu Glu Asp Pro Ala Ser Ala Ile Leu Leu Trp Thr Gln Ile Phe 
225                 230                 235                 240 

Gly His Pro Gly Leu Thr Cys Asp Asp Leu Asp Trp Leu Arg Glu Thr 
                245                 250                 255     

Thr Asp Leu Pro Leu Leu Leu Lys Gly Ile Leu His Pro Asp Asp Ala 
            260                 265                 270         

Glu Glu Ala Phe Arg Arg Gly Ala Asp Gly Ile Ile Val Ser Asn His 
        275                 280                 285             

Gly Gly Arg Gln Val Asp Gly Ala Val Pro Ser Leu Asp Ala Leu Val 
    290                 295                 300                 

Ala Ile Arg Glu Arg Val Gly Arg Glu Lys Val Val Leu Met Asp Gly 
305                 310                 315                 320 

Gly Val Arg Arg Gly Ser Asp Val Val Lys Ala Leu Ala Leu Gly Ala 
                325                 330                 335     

Asn Ala Val Leu Val Gly Arg Leu Tyr Ala Tyr Gly Leu Ala Val Asp 
            340                 345                 350         

Gly Glu Arg Gly Val Glu Thr Val Leu Arg Tyr Leu Leu Ala Asp Phe 
        355                 360                 365             

Asp Leu Thr Met Ala Leu Ser Gly His Arg Ser Leu Ser Thr Leu Asp 
    370                 375                 380                 

Val Arg Ala Leu Ala Arg Ala 
385                 390     

<210>   920
<211>   1176
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   920
gtgaagcgga tgaacatcgg caacgaagcg cagtttcaga tttatcagat gcggctcacc       60

ggccaatatg gcggcgatcc gctctgcatc tcgatggagg actgggtcgc gcgagcgcgg      120

gaggtgttat cgccagaggc gttctggtat ctcgcgggcg gatcggggcg gggcgagacg      180

atgcgggcaa acgaggaggc gttcgccaag tggcggattg tgccccgcgt gttccgcgac      240

gtgtcggttc gagacctgtc catcgagctt ttcggcgagc ggctgcctta tcccgtgctc      300

ctcgcgccca tcggcgtgca gtccatcctg cacgccgatg gggaggtggc ggcggtgcgg      360

ggcgccgcga aggtgggact tccgtacatc gtgagttcgg catcgaccat gccacttgag      420

accatcgccg aaaaggcgcc cggcgcgaca ctctggttcc agctctactg gtcgagggat      480

cgagatgttg cccagagctt cgtgcgccgc gccgaggccg ccggctgcaa ggcgctcgtc      540

gtcacgctcg acacacccat gatggcctgg cgggagcggg atcttgagcg cgcgtacttg      600

ccttttttgc tcggcgaagg actcgggaac tatctctcgg atccggcgtt tcgcgcgaag      660

ctgcgccggc ctcccgagga agatccggcg agcgccatcc tcctctggac gcaaattttc      720

ggccacccgg gcctcacgtg tgacgatctc gactggctgc gggagacgac agatcttccg      780

ctcctcctga aggggattct ccatcccgac gacgccgagg aggcgtttcg ccgcggagcg      840

gacggcatca tcgtttcgaa ccacggcggc cggcaggtgg acggggccgt cccatcgctg      900

gacgcgctgg tcgccatacg ggaacgcgtc ggccgcgaga aggtggtcct catggacggc      960

ggtgtgcggc gcggctccga cgtggtgaag gcgcttgcgc tcggtgcgaa cgccgtgctg     1020

gtgggccgac tgtatgccta cggcctcgcg gtcgacggcg agcgcggtgt ggagaccgtg     1080

ctgcggtatc tcctcgcgga cttcgatctc acgatggccc tgtctggaca ccgttcgctt     1140

tcgacgctcg acgtacgcgc actcgcccgc gcgtag                               1176


<210>   921
<211>   371
<212>   PRT
<213>   Streptomyces avermitilis MA-4680

<400>   921
Gln Tyr Glu Ile Tyr Leu Asn Gly Met Thr Gly Ala Val Pro Arg Leu 
                5                   10                  15      

Pro Thr Asp Leu Thr Arg Leu Glu Glu Leu Thr Glu Gln Arg Leu Gly 
            20                  25                  30          

Pro Gly Pro Val Gly Tyr Val Ala Gly Gly Ala Gly Asn Gly Ser Thr 
        35                  40                  45              

Ala Arg Ala Asn Arg Ser Ala Leu Asp Arg Arg Arg Ile Val Pro Arg 
    50                  55                  60                  

Met Leu Arg Asp Val His Glu Arg Asp Leu Ser Val Glu Val Leu Gly 
65                  70                  75                  80  

Arg Thr Leu Pro Ala Pro Leu Ala Leu Ala Pro Val Gly Val Leu Ser 
                85                  90                  95      

Ile Met His Pro Asp Ala Glu Ser Ala Ala Ala Arg Ala Ala Ala Ala 
            100                 105                 110         

Gln Gly Val Pro Tyr Ile Leu Ser Ser Ala Ser Ser Thr Pro Met Glu 
        115                 120                 125             

Arg Val Ala Glu Ala Met Gly Asp Ala Glu Arg Trp Phe Gln Leu Tyr 
    130                 135                 140                 

Trp Ala Lys Asp Arg Glu Val Thr Arg Ser Phe Leu Asn Arg Ala Lys 
145                 150                 155                 160 

Ala Ala Gly Tyr Thr Ala Leu Phe Val Thr Leu Asp Thr Pro Leu Leu 
                165                 170                 175     

Ala Trp Arg Pro Arg Asp Leu Asp Gln Ala Tyr Leu Pro Phe Leu His 
            180                 185                 190         

Gly Val Gly Thr Ala Asn Tyr Phe Thr Asp Pro Ala Phe Arg Ala Gly 
        195                 200                 205             

Leu Ala Lys Pro Val His Glu Asp Pro Asn Ala Ala Val Met His Phe 
    210                 215                 220                 

Val Ser Met Phe Ala Asp Pro Gly Lys Thr Trp Pro Asp Leu Glu Phe 
225                 230                 235                 240 

Leu Arg Glu Asn Trp Asp Gly Pro Ile Val Leu Lys Gly Ile Leu His 
                245                 250                 255     

Pro Asp Asp Ala Arg Arg Ala Ala Ser Ala Gly Met Asp Gly Val Val 
            260                 265                 270         

Val Ser Asn His Gly Gly Arg Gln Val Ala Gly Ser Val Ala Ala Ala 
        275                 280                 285             

Asp Ala Leu Pro Arg Val Val Glu Ala Ala Gly Asp Arg Leu Thr Val 
    290                 295                 300                 

Leu Phe Asp Ser Gly Ile Arg Thr Gly Asp Asp Ile Phe Lys Ala Leu 
305                 310                 315                 320 

Ala Leu Gly Ala Arg Ala Val Leu Val Gly Arg Pro Tyr Ala Tyr Gly 
                325                 330                 335     

Leu Gly Leu Asp Gly Gln Ala Gly Val Glu His Val Val Arg Cys Leu 
            340                 345                 350         

Leu Ala Glu Phe Asp Leu Thr Leu Ala Leu Ser Gly His Ala Gly Pro 
        355                 360                 365             

Gly Thr Leu 
    370     

<210>   922
<211>   370
<212>   PRT
<213>   Streptomyces ambofaciens ATCC 23877

<400>   922
Gln Tyr Glu Ile Tyr Leu Asn Gly Met Thr Gly Ala Val Pro Arg Leu 
                5                   10                  15      

Pro Thr Asp Leu Thr Arg Leu Glu Glu Leu Ala Glu Arg Arg Leu Gly 
            20                  25                  30          

Pro Gly Pro Val Gly Tyr Val Ala Gly Ser Ala Gly Asp Gly Ser Ala 
        35                  40                  45              

Ala Arg Ala Asn Arg Ala Ala Leu Asp Arg Arg Arg Ile Val Pro Arg 
    50                  55                  60                  

Met Leu Arg Asp Val His Arg Arg Asp Leu Ser Val Glu Val Leu Gly 
65                  70                  75                  80  

Arg Pro Leu Pro Ala Pro Leu Ala Leu Ala Pro Val Gly Val Leu Ser 
                85                  90                  95      

Ile Met His Pro Asp Ala Glu Pro Ala Ala Ala Arg Ala Ala Ala Ala 
            100                 105                 110         

Gln Gly Val Pro Tyr Ile Leu Ser Ser Ala Ser Ser Thr Pro Met Glu 
        115                 120                 125             

Gln Val Ala Glu Ala Met Gly Asp Ala Glu Arg Trp Phe Gln Leu Tyr 
    130                 135                 140                 

Trp Pro Lys Asp Arg Glu Val Ala Arg Ser Phe Leu Glu Arg Ala Arg 
145                 150                 155                 160 

Ala Ala Gly Tyr Ser Ala Leu Phe Val Thr Leu Asp Thr Pro Leu Leu 
                165                 170                 175     

Ser Trp Arg Pro Arg Asp Leu Asp Gln Ala Tyr Leu Pro Phe Leu His 
            180                 185                 190         

Gly Val Gly Thr Ala Asn Tyr Phe Ser Asp Pro Ala Phe Arg Ala Gly 
        195                 200                 205             

Leu Ala Lys Pro Val His Glu Asp Pro Asn Ala Ala Val Met His Phe 
    210                 215                 220                 

Val Gly Met Phe Ser Asp Pro Ala Lys Thr Trp Pro Asp Leu Ala Phe 
225                 230                 235                 240 

Leu Arg Glu Asn Trp Asp Gly Pro Ile Val Leu Lys Gly Val Leu His 
                245                 250                 255     

Pro Asp Asp Ala Arg Met Ala Ala Asp Ala Gly Met Asp Gly Val Val 
            260                 265                 270         

Val Ser Asn His Gly Gly Arg Gln Val Ala Gly Ser Val Ala Ala Ala 
        275                 280                 285             

Asp Ala Leu Pro Arg Val Val Glu Ala Ala Gly Asp Arg Leu Thr Val 
    290                 295                 300                 

Leu Phe Asp Ser Gly Val Arg Thr Gly Asp Asp Val Phe Lys Ala Leu 
305                 310                 315                 320 

Ala Leu Gly Ala Arg Ala Val Leu Leu Gly Arg Pro Tyr Ala Tyr Gly 
                325                 330                 335     

Leu Gly Leu Asp Gly Gln Ala Gly Val Glu His Val Ile Arg Cys Leu 
            340                 345                 350         

Leu Ala Glu Leu Asp Leu Thr Leu Ala Leu Ser Gly His Ser Ser Pro 
        355                 360                 365             

Ala Thr 
    370 

<210>   923
<211>   370
<212>   PRT
<213>   Streptomyces coelicolor A3(2)

<400>   923
Gln Tyr Glu Ile Tyr Leu Asn Gly Met Thr Gly Ala Val Pro Arg Leu 
                5                   10                  15      

Pro Thr Asp Leu Thr Arg Leu Glu Glu Leu Thr Glu Arg Arg Leu Gly 
            20                  25                  30          

Pro Gly Pro Phe Gly Tyr Val Ala Gly Ser Ala Gly Asp Gly Ser Thr 
        35                  40                  45              

Ala Arg Ala Asn Arg Ala Ala Leu Ala Arg Arg Arg Ile Val Pro Arg 
    50                  55                  60                  

Met Leu Arg Asp Val His Glu Arg Asp Leu Arg Val Glu Val Leu Gly 
65                  70                  75                  80  

Arg Ser Leu Pro Ala Pro Leu Ala Leu Ala Pro Val Gly Val Leu Ser 
                85                  90                  95      

Ile Met His Pro Glu Ala Glu Pro Ala Ala Ala Arg Ala Ala Ala Ala 
            100                 105                 110         

Gln Gly Val Pro Tyr Ile Leu Ser Ser Ala Ser Ser Thr Pro Met Glu 
        115                 120                 125             

Glu Val Ala Glu Ala Met Gly Asp Ala Glu Arg Trp Phe Gln Leu Tyr 
    130                 135                 140                 

Trp Pro Lys Asp Arg Glu Val Ala Arg Ser Phe Leu Asp Arg Ala Arg 
145                 150                 155                 160 

Ala Ala Gly Tyr Thr Ala Leu Phe Val Thr Leu Asp Thr Pro Leu Leu 
                165                 170                 175     

Ser Trp Arg Pro Arg Asp Leu Asp Gln Ala Tyr Leu Pro Phe Leu His 
            180                 185                 190         

Gly Val Gly Thr Ala Asn Tyr Phe Ser Asp Pro Ala Phe Arg Ala Gly 
        195                 200                 205             

Leu Ala Lys Pro Val His Glu Asp Pro Asn Ala Ala Val Met His Phe 
    210                 215                 220                 

Val Gly Met Phe Ser Asp Pro Ala Lys Ser Trp Pro Asp Leu Ala Phe 
225                 230                 235                 240 

Leu Arg Glu Asn Trp Asp Gly Pro Ile Val Leu Lys Gly Val Leu His 
                245                 250                 255     

Pro Asp Asp Ala Arg Leu Ala Ala Asp Ala Gly Met Asp Gly Val Val 
            260                 265                 270         

Val Ser Asn His Gly Gly Arg Gln Val Ala Gly Ser Val Ala Ala Ala 
        275                 280                 285             

Asp Ala Leu Pro Arg Val Ala Glu Ala Val Gly Asp Arg Leu Thr Val 
    290                 295                 300                 

Leu Phe Asp Ser Gly Val Arg Thr Gly Asp Asp Val Phe Lys Ala Leu 
305                 310                 315                 320 

Ala Leu Gly Ala Arg Ala Val Leu Leu Gly Arg Pro Tyr Val Tyr Gly 
                325                 330                 335     

Leu Gly Leu Asp Gly Arg Pro Gly Val Glu His Val Ile Arg Cys Leu 
            340                 345                 350         

Leu Ala Glu Leu Asp Leu Thr Leu Ala Leu Ser Gly His Ala Ser Pro 
        355                 360                 365             

Ala Thr 
    370 

<210>   924
<211>   354
<212>   PRT
<213>   Saccharopolyspora erythraea NRRL 2338

<400>   924
Ser Met Glu Glu His Ala Arg Ala Val Leu Pro Ala Asn Ala Tyr Gly 
                5                   10                  15      

Tyr Val Ala Gly Asn Ala Gly Val Gly Ala Thr Gly Arg Ala Asn Arg 
            20                  25                  30          

Gln Ala Phe Asp Gln Trp Arg Leu Val Pro Arg Met Leu Arg Gly Ala 
        35                  40                  45              

Thr Arg Arg Asp Leu Thr Val Ser Leu Phe Gly Gln Arg Leu Ala Ala 
    50                  55                  60                  

Pro Val Leu Leu Ala Pro Ile Ala Ala Gln Thr Val Val His Pro Glu 
65                  70                  75                  80  

Gly Glu Leu Ala Ala Val Arg Gly Ala Ala Asp Ala Gly Val Pro Phe 
                85                  90                  95      

Val Leu Ser Thr Gly Ala Ser His Pro Leu Glu Asp Val Ala Ala Ala 
            100                 105                 110         

Ala Gly Gly Gln Pro Arg Trp Phe Gln Leu Tyr Trp Pro Ala His Arg 
        115                 120                 125             

Ala Val Cys Glu Ser Leu Val Arg Arg Ala Glu Ala Ser Gly Tyr Ser 
    130                 135                 140                 

Ala Leu Val Leu Thr Val Asp Ser Pro Ser Phe Gly Tyr Arg Pro Ala 
145                 150                 155                 160 

Asp Leu Asp Asn Gly Tyr Leu Pro Phe Leu Asn Gly Ala Gly Ile Ala 
                165                 170                 175     

Asn Phe Val Ser Asp Pro Glu Phe Gln Gly Gly Leu Pro Ser Asp Ala 
            180                 185                 190         

Gly Glu Arg Glu Val Val Glu His Trp Ala Arg Val Phe Ala Asn Pro 
        195                 200                 205             

Gly Leu Thr Trp Asp Asp Leu Pro Trp Leu Arg Ser Leu Thr Gly Leu 
    210                 215                 220                 

Pro Ile Val Ile Lys Gly Val Leu His Ala Asp Asp Ala Arg Arg Ala 
225                 230                 235                 240 

Val Glu Leu Gly Ala Asp Gly Leu Val Val Ser Asn His Gly Gly Arg 
                245                 250                 255     

Gln Leu Asp Gly Ser Val Ala Ser Leu Asp Ala Leu Pro Ala Val Arg 
            260                 265                 270         

Ala Ala Val Gly Asp Gly Val Pro Val Leu Leu Asp Ser Gly Val Arg 
        275                 280                 285             

Thr Gly Ser Asp Val Val Lys Ala Leu Ala Leu Gly Ala Asp Ala Val 
    290                 295                 300                 

Leu Tyr Gly Arg Pro Tyr Val Tyr Gly Leu Ala Leu Asp Gly Gln Glu 
305                 310                 315                 320 

Gly Val Ser His Val Leu Arg Cys Leu Leu Ala Glu Leu Asp Leu Ala 
                325                 330                 335     

Leu Ala Leu Thr Gly Ser Gly Ala Val Ser Glu Ile Thr Ala Asp Leu 
            340                 345                 350         

Leu Ala 
        

<210>   925
<211>   358
<212>   PRT
<213>   Haloquadratum walsbyi DSM 16790

<400>   925
Val Ser Phe Ser Asp Leu Arg Glu Glu Ala Phe Glu Glu Met Ser Trp 
                5                   10                  15      

Lys Ala Lys Ala Tyr Val His Gly Gly Ala Gly Thr Glu Glu Thr Phe 
            20                  25                  30          

Glu Arg Asn Lys Asp Phe Ser Arg Trp Arg Ile Ile Pro Arg Met Leu 
        35                  40                  45              

Arg Gly Val Ala Asp Arg Asp Leu Ser Thr Thr Val Leu Gly Asn Glu 
    50                  55                  60                  

His Ser Tyr Pro Leu Met Ile Thr Pro Leu Gly Val Gln Ser Leu Leu 
65                  70                  75                  80  

His Asp Asp Gly Glu Ile Ala Thr Ala Arg Ala Cys Ala Glu Met Asp 
                85                  90                  95      

Val Pro Phe Val Leu Ser Ser Leu Ser Ser Ala Thr Met Glu Asp Val 
            100                 105                 110         

Ala Glu Ala Leu Gly Asp Thr Pro Lys Trp Phe Gln Tyr Tyr Trp Ala 
        115                 120                 125             

Ser Asp Arg Asp Val Ala Thr Ser Phe Leu Asp Arg Ala Glu Thr Ala 
    130                 135                 140                 

Gly Tyr Asp Ala Ile Val Val Thr Val Asp Ala Pro Thr Leu Gly Trp 
145                 150                 155                 160 

Arg Asp Arg Leu Leu Glu Lys Gly Tyr Tyr Pro Phe Leu Glu Gly Glu 
                165                 170                 175     

Gly Ile Gly Asn Tyr Phe Ser Asp Pro Ala Phe Arg Asp Ser Leu Ala 
            180                 185                 190         

Arg Pro Pro Glu Glu Asp Pro Glu Ala Ala Val Asp Arg Phe Leu Ser 
        195                 200                 205             

Ile Phe Gly Asp Ala Ser Leu Thr Trp Asp Asp Leu Ala Phe Val Arg 
    210                 215                 220                 

Glu Gln Thr Asp Leu Pro Ile Ile Ile Lys Gly Val Leu His Pro Asp 
225                 230                 235                 240 

Asp Ala Arg Arg Ala Val Glu Ala Gly Ala Asp Ala Val Gln Val Ser 
                245                 250                 255     

Thr His Gly Gly Arg Gln Val Asp Gly Ser Ile Ala Ala Ile Glu Ala 
            260                 265                 270         

Leu Pro Glu Ile Ala Glu Ala Val Gly Asp Glu Thr Thr Val Leu Phe 
        275                 280                 285             

Asp Ser Gly Ile Arg Arg Gly Ala Gln Ala Phe Lys Ala Leu Ala Leu 
    290                 295                 300                 

Gly Ala Asp Thr Val Leu Leu Gly Arg Pro Phe Ala Tyr Gly Leu Ala 
305                 310                 315                 320 

His Ser Gly Gln Glu Gly Val Glu Gln Val Leu Glu Asn Thr Leu Ser 
                325                 330                 335     

Gln Ile Asp Leu Thr Met Gly Leu Ala Gly Ile Asp Asp Val Asp Asp 
            340                 345                 350         

Ile Asp Arg Ser Ala Val 
        355             

<210>   926
<211>   391
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 919

<400>   926
Met Lys Arg Met Asn Ile Gly Asn Glu Ala Gln Phe Gln Ile Tyr Gln 
                5                   10                  15      

Met Arg Leu Thr Gly Gln Tyr Gly Gly Asp Pro Leu Cys Ile Ser Met 
            20                  25                  30          

Glu Asp Trp Val Ala Arg Ala Arg Glu Val Leu Ser Pro Glu Ala Phe 
        35                  40                  45              

Trp Tyr Leu Ala Gly Gly Ser Gly Arg Gly Glu Thr Met Arg Ala Asn 
    50                  55                  60                  

Glu Glu Ala Phe Ala Lys Trp Arg Ile Val Pro Arg Val Phe Arg Asp 
65                  70                  75                  80  

Val Ser Val Arg Asp Leu Ser Ile Glu Leu Phe Gly Glu Arg Leu Pro 
                85                  90                  95      

Tyr Pro Val Leu Leu Ala Pro Ile Gly Val Gln Ser Ile Leu His Ala 
            100                 105                 110         

Asp Gly Glu Val Ala Ala Val Arg Gly Ala Ala Lys Val Gly Leu Pro 
        115                 120                 125             

Tyr Ile Val Ser Ser Ala Ser Thr Met Pro Leu Glu Thr Ile Ala Glu 
    130                 135                 140                 

Lys Ala Pro Gly Ala Thr Leu Trp Phe Gln Leu Tyr Trp Ser Arg Asp 
145                 150                 155                 160 

Arg Asp Val Ala Gln Ser Phe Val Arg Arg Ala Glu Ala Ala Gly Cys 
                165                 170                 175     

Lys Ala Leu Val Val Thr Leu Asp Thr Pro Met Met Ala Trp Arg Glu 
            180                 185                 190         

Arg Asp Leu Glu Arg Ala Tyr Leu Pro Phe Leu Leu Gly Glu Gly Leu 
        195                 200                 205             

Gly Asn Tyr Leu Ser Asp Pro Ala Phe Arg Ala Lys Leu Arg Arg Pro 
    210                 215                 220                 

Pro Glu Glu Asp Pro Ala Ser Ala Ile Leu Leu Trp Thr Gln Ile Phe 
225                 230                 235                 240 

Gly His Pro Gly Leu Thr Cys Asp Asp Leu Asp Trp Leu Arg Glu Thr 
                245                 250                 255     

Thr Asp Leu Pro Leu Leu Leu Lys Gly Ile Leu His Pro Asp Asp Ala 
            260                 265                 270         

Glu Glu Ala Phe Arg Arg Gly Ala Asp Gly Ile Ile Val Ser Asn His 
        275                 280                 285             

Gly Gly Arg Gln Val Asp Gly Ala Val Pro Ser Leu Asp Ala Leu Val 
    290                 295                 300                 

Ala Ile Arg Glu Arg Val Gly Arg Glu Lys Val Val Leu Met Asp Gly 
305                 310                 315                 320 

Gly Val Arg Arg Gly Ser Asp Val Val Lys Ala Leu Ala Leu Gly Ala 
                325                 330                 335     

Asn Ala Val Leu Val Gly Arg Leu Tyr Ala Tyr Gly Leu Ala Val Asp 
            340                 345                 350         

Gly Glu Arg Gly Val Glu Thr Val Leu Arg Tyr Leu Leu Ala Asp Phe 
        355                 360                 365             

Asp Leu Thr Met Ala Leu Ser Gly His Arg Ser Leu Ser Thr Leu Asp 
    370                 375                 380                 

Val Arg Ala Ile Ala Arg Ala 
385                 390     

<210>   927
<211>   391
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 919

<400>   927
Met Lys Arg Met Asn Ile Gly Asn Glu Ala Gln Phe Gln Ile Tyr Gln 
                5                   10                  15      

Met Arg Leu Thr Gly Gln Tyr Gly Gly Asp Pro Leu Cys Ile Ser Met 
            20                  25                  30          

Glu Asp Trp Val Ala Arg Ala Arg Glu Val Leu Ser Pro Glu Ala Phe 
        35                  40                  45              

Trp Tyr Leu Ala Gly Gly Ser Gly Arg Gly Glu Thr Met Arg Ala Asn 
    50                  55                  60                  

Glu Glu Ala Phe Ala Lys Trp Arg Ile Val Pro Arg Val Phe Arg Asp 
65                  70                  75                  80  

Val Ser Val Arg Asp Leu Ser Ile Glu Leu Phe Gly Glu Arg Leu Pro 
                85                  90                  95      

Tyr Pro Val Leu Leu Ala Pro Ile Gly Val Gln Ser Ile Leu His Ala 
            100                 105                 110         

Asp Gly Glu Val Ala Ala Val Arg Gly Ala Ala Lys Ile Gly Leu Pro 
        115                 120                 125             

Tyr Ile Val Ser Ser Ala Ser Thr Met Pro Leu Glu Thr Ile Ala Glu 
    130                 135                 140                 

Lys Ala Pro Gly Ala Thr Leu Trp Phe Gln Leu Tyr Trp Ser Arg Asp 
145                 150                 155                 160 

Arg Asp Val Ala Gln Ser Phe Val Arg Arg Ala Glu Ala Ala Gly Cys 
                165                 170                 175     

Lys Ala Leu Val Val Thr Leu Asp Thr Pro Met Met Ala Trp Arg Glu 
            180                 185                 190         

Arg Asp Leu Glu Arg Ala Tyr Leu Pro Phe Leu Leu Gly Glu Gly Leu 
        195                 200                 205             

Gly Asn Tyr Leu Ser Asp Pro Ala Phe Arg Ala Lys Leu Arg Arg Pro 
    210                 215                 220                 

Pro Glu Glu Asp Pro Ala Ser Ala Ile Leu Leu Trp Thr Gln Ile Phe 
225                 230                 235                 240 

Gly His Pro Gly Leu Thr Cys Asp Asp Leu Asp Trp Leu Arg Glu Thr 
                245                 250                 255     

Thr Asp Leu Pro Leu Leu Leu Lys Gly Ile Leu His Pro Asp Asp Ala 
            260                 265                 270         

Glu Glu Ala Phe Arg Arg Gly Ala Asp Gly Ile Ile Val Ser Asn His 
        275                 280                 285             

Gly Gly Arg Gln Val Asp Gly Ala Val Pro Ser Leu Asp Ala Leu Val 
    290                 295                 300                 

Ala Ile Arg Glu Arg Val Gly Arg Glu Lys Val Val Leu Met Asp Gly 
305                 310                 315                 320 

Gly Val Arg Arg Gly Ser Asp Val Val Lys Ala Leu Ala Leu Gly Ala 
                325                 330                 335     

Asn Ala Val Leu Val Gly Arg Leu Tyr Ala Tyr Gly Leu Ala Val Asp 
            340                 345                 350         

Gly Glu Arg Gly Val Glu Thr Val Leu Arg Tyr Leu Leu Ala Asp Phe 
        355                 360                 365             

Asp Leu Thr Met Ala Leu Ser Gly His Arg Ser Leu Ser Thr Leu Asp 
    370                 375                 380                 

Val Arg Ala Leu Ala Arg Ala 
385                 390     

<210>   928
<211>   391
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 919

<400>   928
Met Lys Arg Met Asn Ile Gly Asn Glu Ala Gln Phe Gln Ile Tyr Gln 
                5                   10                  15      

Met Arg Leu Thr Gly Gln Tyr Gly Gly Asp Pro Leu Cys Ile Ser Met 
            20                  25                  30          

Glu Asp Trp Val Ala Arg Ala Arg Glu Val Leu Ser Pro Glu Ala Phe 
        35                  40                  45              

Trp Tyr Leu Ala Gly Gly Ser Gly Arg Gly Glu Thr Met Arg Ala Asn 
    50                  55                  60                  

Glu Glu Ala Phe Ala Lys Trp Arg Ile Val Pro Arg Val Phe Arg Asp 
65                  70                  75                  80  

Val Ser Val Arg Asp Leu Ser Ile Glu Leu Phe Gly Glu Arg Leu Pro 
                85                  90                  95      

Tyr Pro Val Leu Leu Ala Pro Ile Gly Val Gln Ser Ile Leu His Ala 
            100                 105                 110         

Asp Gly Glu Val Ala Ala Val Arg Gly Ala Ala Lys Val Gly Leu Pro 
        115                 120                 125             

Tyr Ile Val Ser Ser Ala Ser Thr Met Pro Leu Glu Thr Ile Ala Glu 
    130                 135                 140                 

Lys Ala Pro Gly Ala Thr Leu Trp Phe Gln Leu Tyr Trp Ser Arg Asp 
145                 150                 155                 160 

Arg Asp Val Ala Gln Ser Phe Val Lys Arg Ala Glu Ala Ala Gly Cys 
                165                 170                 175     

Lys Ala Leu Val Val Thr Leu Asp Thr Pro Met Met Ala Trp Arg Glu 
            180                 185                 190         

Arg Asp Leu Glu Arg Ala Tyr Leu Pro Phe Leu Leu Gly Glu Gly Leu 
        195                 200                 205             

Gly Asn Tyr Leu Ser Asp Pro Ala Phe Arg Ala Lys Leu Arg Arg Pro 
    210                 215                 220                 

Pro Glu Glu Asp Pro Ala Ser Ala Ile Leu Leu Trp Thr Gln Ile Phe 
225                 230                 235                 240 

Gly His Pro Gly Leu Thr Cys Asp Asp Leu Asp Trp Leu Arg Glu Thr 
                245                 250                 255     

Thr Asp Leu Pro Leu Leu Leu Lys Gly Ile Leu His Pro Asp Asp Ala 
            260                 265                 270         

Glu Glu Ala Phe Arg Arg Gly Ala Asp Gly Ile Ile Val Ser Asn His 
        275                 280                 285             

Gly Gly Arg Gln Val Asp Gly Ala Val Pro Ser Leu Asp Ala Leu Val 
    290                 295                 300                 

Ala Ile Arg Glu Arg Val Gly Arg Glu Lys Val Val Leu Met Asp Gly 
305                 310                 315                 320 

Gly Val Arg Arg Gly Ser Asp Val Val Lys Ala Leu Ala Leu Gly Ala 
                325                 330                 335     

Asn Ala Val Leu Val Gly Arg Leu Tyr Ala Tyr Gly Leu Ala Val Asp 
            340                 345                 350         

Gly Glu Arg Gly Val Glu Thr Val Leu Arg Tyr Leu Leu Ala Asp Phe 
        355                 360                 365             

Asp Leu Thr Met Ala Leu Ser Gly His Arg Ser Leu Ser Thr Leu Asp 
    370                 375                 380                 

Val Arg Ala Leu Ala Arg Ala 
385                 390     

<210>   929
<211>   391
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 919

<400>   929
Met Lys Arg Met Asn Ile Gly Asn Glu Ala Gln Phe Gln Ile Tyr Gln 
                5                   10                  15      

Met Arg Leu Thr Gly Gln Tyr Gly Gly Asp Pro Leu Cys Ile Ser Met 
            20                  25                  30          

Glu Asp Trp Val Ala Arg Ala Arg Glu Val Leu Ser Pro Glu Ala Phe 
        35                  40                  45              

Trp Tyr Leu Ala Gly Gly Ser Gly Arg Gly Glu Thr Met Arg Ala Asn 
    50                  55                  60                  

Glu Glu Ala Phe Ala Lys Trp Arg Ile Val Pro Arg Val Phe Arg Asp 
65                  70                  75                  80  

Val Ser Val Arg Asp Leu Ser Ile Glu Leu Phe Gly Glu Arg Leu Pro 
                85                  90                  95      

Tyr Pro Val Leu Leu Ala Pro Ile Gly Val Gln Ser Ile Leu His Ala 
            100                 105                 110         

Asp Gly Glu Val Ala Ala Val Arg Gly Ala Ala Lys Val Gly Leu Pro 
        115                 120                 125             

Tyr Ile Val Ser Ser Ala Ser Thr Met Pro Leu Glu Thr Ile Ala Glu 
    130                 135                 140                 

Lys Ala Pro Gly Ala Thr Leu Trp Phe Gln Leu Tyr Trp Ser Arg Asp 
145                 150                 155                 160 

Arg Asp Val Ala Gln Ser Phe Val Arg Arg Ala Glu Ala Ala Gly Cys 
                165                 170                 175     

Lys Ala Leu Val Val Thr Leu Asp Thr Pro Met Met Ala Trp Arg Glu 
            180                 185                 190         

Arg Asp Leu Glu Arg Ala Tyr Leu Pro Phe Leu Leu Gly Glu Gly Leu 
        195                 200                 205             

Gly Asn Tyr Leu Ser Asp Pro Ala Phe Arg Ala Lys Leu Arg Arg Pro 
    210                 215                 220                 

Pro Glu Glu Asp Pro Ala Ser Ala Ile Leu Leu Trp Thr Gln Ile Phe 
225                 230                 235                 240 

Gly His Pro Gly Leu Thr Cys Asp Asp Leu Asp Trp Leu Arg Glu Thr 
                245                 250                 255     

Thr Asp Leu Pro Leu Leu Leu Lys Gly Ile Leu His Pro Asp Asp Ala 
            260                 265                 270         

Glu Glu Ala Phe Arg Arg Gly Ala Asp Gly Ile Ile Val Ser Asn His 
        275                 280                 285             

Gly Gly Arg Gln Val Asp Gly Ala Val Pro Ser Leu Asp Ala Leu Val 
    290                 295                 300                 

Ala Ile Lys Glu Arg Val Gly Arg Glu Lys Val Val Leu Met Asp Gly 
305                 310                 315                 320 

Gly Val Arg Arg Gly Ser Asp Val Val Lys Ala Leu Ala Leu Gly Ala 
                325                 330                 335     

Asn Ala Val Leu Val Gly Arg Leu Tyr Ala Tyr Gly Leu Ala Val Asp 
            340                 345                 350         

Gly Glu Arg Gly Val Glu Thr Val Leu Arg Tyr Leu Leu Ala Asp Phe 
        355                 360                 365             

Asp Leu Thr Met Ala Leu Ser Gly His Arg Ser Leu Ser Thr Leu Asp 
    370                 375                 380                 

Val Arg Ala Leu Ala Arg Ala 
385                 390     

<210>   930
<211>   391
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 919

<400>   930
Met Lys Arg Met Asn Ile Gly Asn Glu Ala Gln Phe Gln Ile Tyr Gln 
                5                   10                  15      

Met Arg Leu Thr Gly Gln Tyr Gly Gly Asp Pro Leu Cys Ile Ser Met 
            20                  25                  30          

Glu Asp Trp Val Ala Arg Ala Arg Glu Val Leu Ser Pro Glu Ala Phe 
        35                  40                  45              

Trp Tyr Leu Ala Gly Gly Ser Gly Arg Gly Glu Thr Met Arg Ala Asn 
    50                  55                  60                  

Glu Glu Ala Phe Ala Lys Trp Arg Ile Val Pro Arg Val Phe Arg Asp 
65                  70                  75                  80  

Val Ser Val Arg Asp Leu Ser Ile Glu Leu Phe Gly Glu Arg Leu Pro 
                85                  90                  95      

Tyr Pro Val Leu Leu Ala Pro Ile Gly Val Gln Ser Ile Leu His Ala 
            100                 105                 110         

Asp Gly Glu Val Ala Ala Val Arg Gly Ala Ala Lys Val Gly Leu Pro 
        115                 120                 125             

Tyr Ile Val Ser Ser Ala Ser Thr Met Pro Leu Glu Thr Ile Ala Glu 
    130                 135                 140                 

Lys Ala Pro Gly Ala Thr Leu Trp Phe Gln Leu Tyr Trp Ser Arg Asp 
145                 150                 155                 160 

Arg Asp Val Ala Asn Ser Phe Val Arg Arg Ala Glu Ala Ala Gly Cys 
                165                 170                 175     

Lys Ala Leu Val Val Thr Leu Asp Thr Pro Met Met Ala Trp Arg Glu 
            180                 185                 190         

Arg Asp Leu Glu Arg Ala Tyr Leu Pro Phe Leu Leu Gly Glu Gly Leu 
        195                 200                 205             

Gly Asn Tyr Leu Ser Asp Pro Ala Phe Arg Ala Lys Leu Arg Arg Pro 
    210                 215                 220                 

Pro Glu Glu Asp Pro Ala Ser Ala Ile Leu Leu Trp Thr Gln Ile Phe 
225                 230                 235                 240 

Gly His Pro Gly Leu Thr Cys Asp Asp Leu Asp Trp Leu Arg Glu Thr 
                245                 250                 255     

Thr Asp Leu Pro Leu Leu Leu Lys Gly Ile Leu His Pro Asp Asp Ala 
            260                 265                 270         

Glu Glu Ala Phe Arg Arg Gly Ala Asp Gly Ile Ile Val Ser Asn His 
        275                 280                 285             

Gly Gly Arg Gln Val Asp Gly Ala Val Pro Ser Leu Asp Ala Leu Val 
    290                 295                 300                 

Ala Ile Arg Glu Arg Val Gly Arg Glu Lys Val Val Leu Met Asp Gly 
305                 310                 315                 320 

Gly Val Arg Arg Gly Ser Asp Val Val Lys Ala Leu Ala Leu Gly Ala 
                325                 330                 335     

Asn Ala Val Leu Val Gly Arg Leu Tyr Ala Tyr Gly Leu Ala Val Asp 
            340                 345                 350         

Gly Glu Arg Gly Val Glu Thr Val Leu Arg Tyr Leu Leu Ala Asp Phe 
        355                 360                 365             

Asp Leu Thr Met Ala Leu Ser Gly His Arg Ser Leu Ser Thr Leu Asp 
    370                 375                 380                 

Val Arg Ala Leu Ala Arg Ala 
385                 390     

<210>   931
<211>   1176
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 920

<400>   931
gtgaagcgga tgaacatcgg caacgaagcg cagtttcaga tttatcagat gcggctcacc       60

ggccaatatg gcggcgatcc gctctgcatc tcgatggagg actgggtcgc gcgagcgcgg      120

gaggtgttat cgccagaggc gttctggtat ctcgcgggcg gatcggggcg gggcgagacg      180

atgcgggcaa acgaggaggc gttcgccaag tggcggattg tgccccgcgt gttccgcgac      240

gtgtcggttc gagacctgtc catcgagctt ttcggcgagc ggctgcctta tcccgtgctc      300

ctcgcgccca tcggcgtgca gtccatcctg cacgccgatg gggaggtggc ggcggtgcgg      360

ggcgccgcga aggtgggact tccgtacatc gtgagttcgg catcgaccat gccacttgag      420

accatcgccg aaaaggcgcc cggcgcgaca ctctggttcc agctctactg gtcgagggat      480

cgagatgttg cccagagctt cgtgcgccgc gccgaggccg ccggctgcaa ggcgctcgtc      540

gtcacgctcg acacacccat gatggcctgg cgggagcggg atcttgagcg cgcgtacttg      600

ccttttttgc tcggcgaagg actcgggaac tatctctcgg atccggcgtt tcgcgcgaag      660

ctgcgccggc ctcccgagga agatccggcg agcgccatcc tcctctggac gcaaattttc      720

ggccacccgg gcctcacgtg tgacgatctc gactggctgc gggagacgac agatcttccg      780

ctcctcctga aggggattct ccatcccgac gacgccgagg aggcgtttcg ccgcggagcg      840

gacggcatca tcgtttcgaa ccacggcggc cggcaggtgg acggggccgt cccatcgctg      900

gacgcgctgg tcgccatacg ggaacgcgtc ggccgcgaga aggtggtcct catggacggc      960

ggtgtgcggc gcggctccga cgtggtgaag gcgcttgcgc tcggtgcgaa cgccgtgctg     1020

gtgggccgac tgtatgccta cggcctcgcg gtcgacggcg agcgcggtgt ggagaccgtg     1080

ctgcggtatc tcctcgcgga cttcgatctc acgatggccc tgtctggaca ccgttcgctt     1140

tcgacgctcg acgtacgcgc aattgcccgc gcgtag                               1176


<210>   932
<211>   1176
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 920

<400>   932
gtgaagcgga tgaacatcgg caacgaagcg cagtttcaga tttatcagat gcggctcacc       60

ggccaatatg gcggcgatcc gctctgcatc tcgatggagg actgggtcgc gcgagcgcgg      120

gaggtgttat cgccagaggc gttctggtat ctcgcgggcg gatcggggcg gggcgagacg      180

atgcgggcaa acgaggaggc gttcgccaag tggcggattg tgccccgcgt gttccgcgac      240

gtgtcggttc gagacctgtc catcgagctt ttcggcgagc ggctgcctta tcccgtgctc      300

ctcgcgccca tcggcgtgca gtccatcctg cacgccgatg gggaggtggc ggcggtgcgg      360

ggcgccgcga agattggact tccgtacatc gtgagttcgg catcgaccat gccacttgag      420

accatcgccg aaaaggcgcc cggcgcgaca ctctggttcc agctctactg gtcgagggat      480

cgagatgttg cccagagctt cgtgcgccgc gccgaggccg ccggctgcaa ggcgctcgtc      540

gtcacgctcg acacacccat gatggcctgg cgggagcggg atcttgagcg cgcgtacttg      600

ccttttttgc tcggcgaagg actcgggaac tatctctcgg atccggcgtt tcgcgcgaag      660

ctgcgccggc ctcccgagga agatccggcg agcgccatcc tcctctggac gcaaattttc      720

ggccacccgg gcctcacgtg tgacgatctc gactggctgc gggagacgac agatcttccg      780

ctcctcctga aggggattct ccatcccgac gacgccgagg aggcgtttcg ccgcggagcg      840

gacggcatca tcgtttcgaa ccacggcggc cggcaggtgg acggggccgt cccatcgctg      900

gacgcgctgg tcgccatacg ggaacgcgtc ggccgcgaga aggtggtcct catggacggc      960

ggtgtgcggc gcggctccga cgtggtgaag gcgcttgcgc tcggtgcgaa cgccgtgctg     1020

gtgggccgac tgtatgccta cggcctcgcg gtcgacggcg agcgcggtgt ggagaccgtg     1080

ctgcggtatc tcctcgcgga cttcgatctc acgatggccc tgtctggaca ccgttcgctt     1140

tcgacgctcg acgtacgcgc actcgcccgc gcgtag                               1176


<210>   933
<211>   1176
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 920

<400>   933
gtgaagcgga tgaacatcgg caacgaagcg cagtttcaga tttatcagat gcggctcacc       60

ggccaatatg gcggcgatcc gctctgcatc tcgatggagg actgggtcgc gcgagcgcgg      120

gaggtgttat cgccagaggc gttctggtat ctcgcgggcg gatcggggcg gggcgagacg      180

atgcgggcaa acgaggaggc gttcgccaag tggcggattg tgccccgcgt gttccgcgac      240

gtgtcggttc gagacctgtc catcgagctt ttcggcgagc ggctgcctta tcccgtgctc      300

ctcgcgccca tcggcgtgca gtccatcctg cacgccgatg gggaggtggc ggcggtgcgg      360

ggcgccgcga aggtgggact tccgtacatc gtgagttcgg catcgaccat gccacttgag      420

accatcgccg aaaaggcgcc cggcgcgaca ctctggttcc agctctactg gtcgagggat      480

cgagatgttg cccagagctt cgtgaaacgc gccgaggccg ccggctgcaa ggcgctcgtc      540

gtcacgctcg acacacccat gatggcctgg cgggagcggg atcttgagcg cgcgtacttg      600

ccttttttgc tcggcgaagg actcgggaac tatctctcgg atccggcgtt tcgcgcgaag      660

ctgcgccggc ctcccgagga agatccggcg agcgccatcc tcctctggac gcaaattttc      720

ggccacccgg gcctcacgtg tgacgatctc gactggctgc gggagacgac agatcttccg      780

ctcctcctga aggggattct ccatcccgac gacgccgagg aggcgtttcg ccgcggagcg      840

gacggcatca tcgtttcgaa ccacggcggc cggcaggtgg acggggccgt cccatcgctg      900

gacgcgctgg tcgccatacg ggaacgcgtc ggccgcgaga aggtggtcct catggacggc      960

ggtgtgcggc gcggctccga cgtggtgaag gcgcttgcgc tcggtgcgaa cgccgtgctg     1020

gtgggccgac tgtatgccta cggcctcgcg gtcgacggcg agcgcggtgt ggagaccgtg     1080

ctgcggtatc tcctcgcgga cttcgatctc acgatggccc tgtctggaca ccgttcgctt     1140

tcgacgctcg acgtacgcgc actcgcccgc gcgtag                               1176


<210>   934
<211>   1176
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 920

<400>   934
gtgaagcgga tgaacatcgg caacgaagcg cagtttcaga tttatcagat gcggctcacc       60

ggccaatatg gcggcgatcc gctctgcatc tcgatggagg actgggtcgc gcgagcgcgg      120

gaggtgttat cgccagaggc gttctggtat ctcgcgggcg gatcggggcg gggcgagacg      180

atgcgggcaa acgaggaggc gttcgccaag tggcggattg tgccccgcgt gttccgcgac      240

gtgtcggttc gagacctgtc catcgagctt ttcggcgagc ggctgcctta tcccgtgctc      300

ctcgcgccca tcggcgtgca gtccatcctg cacgccgatg gggaggtggc ggcggtgcgg      360

ggcgccgcga aggtgggact tccgtacatc gtgagttcgg catcgaccat gccacttgag      420

accatcgccg aaaaggcgcc cggcgcgaca ctctggttcc agctctactg gtcgagggat      480

cgagatgttg cccagagctt cgtgcgccgc gccgaggccg ccggctgcaa ggcgctcgtc      540

gtcacgctcg acacacccat gatggcctgg cgggagcggg atcttgagcg cgcgtacttg      600

ccttttttgc tcggcgaagg actcgggaac tatctctcgg atccggcgtt tcgcgcgaag      660

ctgcgccggc ctcccgagga agatccggcg agcgccatcc tcctctggac gcaaattttc      720

ggccacccgg gcctcacgtg tgacgatctc gactggctgc gggagacgac agatcttccg      780

ctcctcctga aggggattct ccatcccgac gacgccgagg aggcgtttcg ccgcggagcg      840

gacggcatca tcgtttcgaa ccacggcggc cggcaggtgg acggggccgt cccatcgctg      900

gacgcgctgg tcgccataaa agaacgcgtc ggccgcgaga aggtggtcct catggacggc      960

ggtgtgcggc gcggctccga cgtggtgaag gcgcttgcgc tcggtgcgaa cgccgtgctg     1020

gtgggccgac tgtatgccta cggcctcgcg gtcgacggcg agcgcggtgt ggagaccgtg     1080

ctgcggtatc tcctcgcgga cttcgatctc acgatggccc tgtctggaca ccgttcgctt     1140

tcgacgctcg acgtacgcgc actcgcccgc gcgtag                               1176


<210>   935
<211>   1176
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 920

<400>   935
gtgaagcgga tgaacatcgg caacgaagcg cagtttcaga tttatcagat gcggctcacc       60

ggccaatatg gcggcgatcc gctctgcatc tcgatggagg actgggtcgc gcgagcgcgg      120

gaggtgttat cgccagaggc gttctggtat ctcgcgggcg gatcggggcg gggcgagacg      180

atgcgggcaa acgaggaggc gttcgccaag tggcggattg tgccccgcgt gttccgcgac      240

gtgtcggttc gagacctgtc catcgagctt ttcggcgagc ggctgcctta tcccgtgctc      300

ctcgcgccca tcggcgtgca gtccatcctg cacgccgatg gggaggtggc ggcggtgcgg      360

ggcgccgcga aggtgggact tccgtacatc gtgagttcgg catcgaccat gccacttgag      420

accatcgccg aaaaggcgcc cggcgcgaca ctctggttcc agctctactg gtcgagggat      480

cgagatgttg ccaatagctt cgtgcgccgc gccgaggccg ccggctgcaa ggcgctcgtc      540

gtcacgctcg acacacccat gatggcctgg cgggagcggg atcttgagcg cgcgtacttg      600

ccttttttgc tcggcgaagg actcgggaac tatctctcgg atccggcgtt tcgcgcgaag      660

ctgcgccggc ctcccgagga agatccggcg agcgccatcc tcctctggac gcaaattttc      720

ggccacccgg gcctcacgtg tgacgatctc gactggctgc gggagacgac agatcttccg      780

ctcctcctga aggggattct ccatcccgac gacgccgagg aggcgtttcg ccgcggagcg      840

gacggcatca tcgtttcgaa ccacggcggc cggcaggtgg acggggccgt cccatcgctg      900

gacgcgctgg tcgccatacg ggaacgcgtc ggccgcgaga aggtggtcct catggacggc      960

ggtgtgcggc gcggctccga cgtggtgaag gcgcttgcgc tcggtgcgaa cgccgtgctg     1020

gtgggccgac tgtatgccta cggcctcgcg gtcgacggcg agcgcggtgt ggagaccgtg     1080

ctgcggtatc tcctcgcgga cttcgatctc acgatggccc tgtctggaca ccgttcgctt     1140

tcgacgctcg acgtacgcgc actcgcccgc gcgtag                               1176


<210>   936
<211>   467
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   936
Met Asn Lys Gly Tyr Val Val Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Arg Phe Pro Glu Gly Gln Leu Pro Ala Ile Asn Asn Ala Leu Arg Ile 
            20                  25                  30          

Asp Tyr Glu Gly Asp Leu Pro Val His Leu Thr Leu Glu Val Ala Leu 
        35                  40                  45              

His Leu Gly Asp Asn Val Val Arg Thr Ile Ala Met Ser Ser Thr Asp 
    50                  55                  60                  

Gly Leu Val Arg Gly Val Glu Val Val Asp Thr Gly Gln Pro Ile Ser 
65                  70                  75                  80  

Met Pro Val Gly Pro Gly Thr Leu Gly Arg Ile Phe Asn Val Leu Gly 
                85                  90                  95      

Glu Thr Ile Asp Glu Arg Gly Pro Val Asp Ala Pro Glu Arg Trp Pro 
            100                 105                 110         

Ile His Arg Pro Ala Pro Ala Phe Gly Asp Leu Thr Thr Lys Thr Glu 
        115                 120                 125             

Ile Phe Glu Thr Gly Ile Lys Val Val Asp Leu Leu Ala Pro Tyr Val 
    130                 135                 140                 

Lys Gly Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr 
145                 150                 155                 160 

Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala Lys Glu His Gly Gly 
                165                 170                 175     

Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp 
            180                 185                 190         

Leu Tyr His Glu Met Lys Glu Ser Gly Val Leu Asp Lys Thr Cys Met 
        195                 200                 205             

Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Leu Arg Val Ala 
    210                 215                 220                 

Leu Ser Gly Leu Thr Leu Ala Glu Tyr Phe Arg Asp Val Glu Gln Arg 
225                 230                 235                 240 

Asp Val Leu Phe Phe Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly 
                245                 250                 255     

Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro Ser Ala Val Gly Tyr 
            260                 265                 270         

Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu Gln Glu Arg Ile Ala 
        275                 280                 285             

Ser Thr Val Arg Gly Ser Ile Thr Ser Ile Gln Ala Val Tyr Val Pro 
    290                 295                 300                 

Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Asn Thr Phe Thr His Leu 
305                 310                 315                 320 

Asp Ala Thr Thr Val Leu Glu Arg Arg Ile Ala Asp Met Gly Leu Tyr 
                325                 330                 335     

Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg Ala Leu Gln Pro Asp 
            340                 345                 350         

Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg Gly Val Gln Ala Val 
        355                 360                 365             

Leu Gln Arg Tyr Arg Glu Leu Gln Asp Ile Ile Ala Ile Leu Gly Met 
    370                 375                 380                 

Asp Glu Leu Thr Asp Glu Asp Arg Leu Ile Val Ser Arg Ala Arg Lys 
385                 390                 395                 400 

Ile Gln Asn Phe Leu Ser Gln Pro Phe Phe Val Ala Glu Val Phe Thr 
                405                 410                 415     

Gly Thr Pro Gly Lys Tyr Val Pro Val Lys Asp Thr Val Arg Ser Phe 
            420                 425                 430         

Lys Glu Ile Leu Glu Gly Lys His Asp Asp Ile Pro Glu Thr Tyr Phe 
        435                 440                 445             

Arg Tyr Cys Gly Ala Ile Glu Asp Val Ile Glu Lys Ala Arg Lys Asp 
    450                 455                 460                 

Gly Tyr Ala 
465         

<210>   937
<211>   1404
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   937
gtgaacaaag ggtatgtagt gcaggtcatg ggcccggtgg tcgatgtccg ctttccagaa       60

ggacaactgc cggcgatcaa caacgccctc cgcattgatt acgagggcga tctgcccgtg      120

catctgacgc tcgaggtggc gctgcacctc ggagacaacg tggttcgaac catcgcgatg      180

tcgtcgacgg acgggctcgt ccgcggcgtc gaagtcgtcg atacagggca gcccatctcg      240

atgcccgtag gaccgggcac cctggggcgc atcttcaacg tgctcggcga gacgattgac      300

gagagggggc ccgtcgatgc cccggagcgc tggccgatcc accgtcccgc gcccgcgttt      360

ggggatctga cgacgaagac cgagatcttc gaaaccggca tcaaggtcgt ggatctgctc      420

gctccgtacg tcaagggcgg taaggttggc ctgttcggcg gcgcgggcgt cggcaaaacg      480

gtgctcattc aggagctcat tcacaacatc gcgaaggagc acggcggtta ttcggtgttc      540

gccggcgtcg gcgagcggac gcgcgagggt aacgacctct accatgaaat gaaggagtcg      600

ggcgtcctcg acaagacgtg catggtgttc ggccagatga acgagccgcc cggtgcgcgc      660

ctccgcgtgg cgctgtccgg cctgacgctc gctgagtact tccgcgatgt ggagcagcgc      720

gacgtcctgt tcttcatcga caacatcttc cgcttcacac aggcgggttc cgaggtgtct      780

gcgcttctcg gccgcatgcc gtcggccgtc ggttaccagc ccaccctggc cacggaaatg      840

ggccaactgc aggaacgcat tgcctcgacg gtgcgagggt ccatcacgtc catccaggcg      900

gtgtacgtgc cggcggacga ctacaccgat ccggcgccgg ccaacacgtt cacccacctc      960

gatgccacga ccgtgttgga gcgccggatc gccgacatgg gcctgtatcc ggcggtcgat     1020

ccgctcgctt cgacgtcgcg ggcgctccag cctgacatcg tgggtgagga gcactatcag     1080

gtggcgcgtg gcgtccaagc ggtgctgcag cggtatcgcg agctgcagga catcatcgcc     1140

atcctcggca tggacgagct gacggatgag gaccgcctca tcgtgtcgcg cgcgcgcaaa     1200

atccagaact tcctgtcgca gccgttcttc gtcgctgagg tgttcaccgg gacgccgggc     1260

aagtacgtgc cggtgaagga taccgtgcgc tcgttcaagg agatcctgga gggcaagcac     1320

gacgacattc cggagacgta cttccgctac tgcggcgcga ttgaagacgt gatcgagaag     1380

gcgcgcaagg acggctacgc ctga                                            1404


<210>   938
<211>   461
<212>   PRT
<213>   Bacillus sp. TA2.A1

<400>   938
Met Asn Lys Gly Arg Ile Ile Gln Val Met Gly Pro Val Val Asp Ile 
                5                   10                  15      

Gln Phe Glu Ser Gly Gln Leu Pro Asp Ile Tyr Asn Ala Ile Thr Ile 
            20                  25                  30          

Glu Arg Pro Gln Gly Gly Thr Leu Thr Val Glu Ala Ala Val His Leu 
        35                  40                  45              

Gly Asp Asn Val Val Arg Cys Val Ala Met Ala Ser Thr Asp Gly Leu 
    50                  55                  60                  

Val Arg Gly Leu Glu Ala Val Asp Thr Gly Ala Pro Ile Ser Val Pro 
65                  70                  75                  80  

Val Gly Lys Ala Thr Leu Gly Arg Val Phe Asn Val Leu Gly Glu Pro 
                85                  90                  95      

Ile Asp Glu Gln Gly Glu Val Asn Ala Glu Glu Arg His Pro Ile His 
            100                 105                 110         

Arg Pro Ala Pro Glu Phe Glu Glu Leu Ser Thr Ala Asp Glu Ile Leu 
        115                 120                 125             

Glu Thr Gly Ile Lys Val Ile Asp Leu Leu Ala Pro Tyr Ala Lys Gly 
    130                 135                 140                 

Gly Lys Ile Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr Val Leu 
145                 150                 155                 160 

Ile Gln Glu Leu Ile Asn Asn Val Ala Gln Glu His Gly Gly Leu Ser 
                165                 170                 175     

Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp Leu Tyr 
            180                 185                 190         

His Glu Met Lys Asp Ser Gly Val Ile Ser Lys Thr Ser Met Val Phe 
        195                 200                 205             

Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Leu Arg Val Ala Leu Thr 
    210                 215                 220                 

Gly Leu Thr Met Ala Glu Tyr Phe Arg Asp Arg Glu Gly Gln Asp Val 
225                 230                 235                 240 

Leu Leu Phe Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu 
                245                 250                 255     

Val Ser Ala Leu Leu Gly Arg Met Pro Ser Ala Val Gly Tyr Gln Pro 
            260                 265                 270         

Thr Leu Ala Thr Glu Met Gly Gln Leu Gln Glu Arg Ile Thr Ser Thr 
        275                 280                 285             

Lys Lys Gly Ser Ile Thr Ser Ile Gln Ala Ile Tyr Val Pro Ala Asp 
    290                 295                 300                 

Asp Tyr Thr Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala 
305                 310                 315                 320 

Thr Thr Asn Leu Glu Arg Lys Leu Ala Glu Met Gly Ile Tyr Pro Ala 
                325                 330                 335     

Val Asp Pro Leu Ala Ser Thr Ser Arg Ile Leu Ser Pro Ala Val Val 
            340                 345                 350         

Gly Glu Glu His Tyr Arg Val Ala Arg Gly Val Gln Gln Val Leu Gln 
        355                 360                 365             

Arg Tyr Asn Asp Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu 
    370                 375                 380                 

Leu Ser Asp Glu Asp Lys Leu Ile Val Ala Arg Ala Arg Lys Ile Gln 
385                 390                 395                 400 

Arg Phe Leu Ser Gln Pro Phe His Val Ala Glu Gln Phe Thr Gly Met 
                405                 410                 415     

Pro Gly Lys Tyr Val Pro Val Lys Glu Thr Val Arg Gly Phe Lys Glu 
            420                 425                 430         

Ile Leu Glu Gly Lys His Asp Asn Leu Pro Glu Glu Ala Phe Tyr Met 
        435                 440                 445             

Val Gly Thr Ile Asp Glu Ala Val Glu Lys Ala Lys Lys 
    450                 455                 460     

<210>   939
<211>   470
<212>   PRT
<213>   Geobacillus thermoleovorans

<400>   939
Met Thr Arg Gly Arg Val Ile Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Lys Phe Glu Asn Gly His Leu Pro Ala Ile Tyr Asn Ala Leu Lys Ile 
            20                  25                  30          

Gln His Lys Ala Arg Asn Glu Asn Glu Val Asp Ile Asp Leu Thr Leu 
        35                  40                  45              

Glu Val Ala Leu His Leu Gly Asp Asp Thr Val Arg Thr Ile Ala Met 
    50                  55                  60                  

Ala Ser Thr Asp Gly Leu Ile Arg Gly Met Glu Val Ile Asp Thr Gly 
65                  70                  75                  80  

Ala Pro Ile Ser Val Pro Val Gly Glu Val Thr Leu Gly Arg Val Phe 
                85                  90                  95      

Asn Val Leu Gly Glu Pro Ile Asp Leu Glu Gly Asp Ile Pro Ala Asp 
            100                 105                 110         

Ala Arg Arg Asp Pro Ile His Arg Pro Ala Pro Lys Phe Glu Glu Leu 
        115                 120                 125             

Ala Thr Glu Val Glu Ile Leu Glu Thr Gly Ile Lys Val Val Asp Leu 
    130                 135                 140                 

Leu Ala Pro Tyr Ile Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
145                 150                 155                 160 

Gly Val Gly Lys Thr Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala 
                165                 170                 175     

Gln Glu His Gly Gly Ile Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
            180                 185                 190         

Arg Glu Gly Asn Asp Leu Tyr His Glu Met Lys Asp Ser Gly Val Ile 
        195                 200                 205             

Ser Lys Thr Ala Met Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala 
    210                 215                 220                 

Arg Met Arg Val Ala Leu Thr Gly Leu Thr Met Ala Glu Tyr Phe Arg 
225                 230                 235                 240 

Asp Glu Gln Gly Gln Asp Val Leu Leu Phe Ile Asp Asn Ile Phe Arg 
                245                 250                 255     

Phe Thr Gln Ala Gly Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro 
            260                 265                 270         

Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu 
        275                 280                 285             

Gln Glu Arg Ile Thr Ser Thr Ala Lys Gly Ser Ile Thr Ser Ile Gln 
    290                 295                 300                 

Ala Ile Tyr Val Pro Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Thr 
305                 310                 315                 320 

Thr Phe Ser His Leu Asp Ala Thr Thr Asn Leu Glu Arg Lys Leu Ala 
                325                 330                 335     

Glu Met Gly Ile Tyr Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg 
            340                 345                 350         

Ala Leu Ala Pro Glu Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg 
        355                 360                 365             

Lys Val Gln Gln Thr Leu Gln Arg Tyr Lys Glu Leu Gln Asp Ile Ile 
    370                 375                 380                 

Ala Ile Leu Gly Met Asp Glu Leu Ser Asp Glu Asp Lys Leu Val Val 
385                 390                 395                 400 

His Arg Ala Arg Arg Ile Gln Phe Phe Leu Ser Gln Asn Phe His Val 
                405                 410                 415     

Ala Glu Gln Phe Thr Gly Gln Pro Gly Ser Tyr Val Pro Val Lys Glu 
            420                 425                 430         

Thr Val Arg Gly Phe Lys Glu Ile Leu Glu Gly Lys Tyr Asp His Leu 
        435                 440                 445             

Pro Glu Asp Arg Phe Arg Leu Val Gly Arg Ile Glu Asp Val Val Glu 
    450                 455                 460                 

Lys Ala Lys Ala Met Gly 
465                 470 

<210>   940
<211>   470
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   940
Met Thr Arg Gly Arg Val Ile Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Lys Phe Glu Asn Gly His Leu Pro Ala Ile Tyr Asn Ala Leu Lys Ile 
            20                  25                  30          

Gln His Lys Ala Arg Asn Glu Asn Glu Val Asp Ile Asp Leu Thr Leu 
        35                  40                  45              

Glu Val Ala Leu His Leu Gly Asp Asp Thr Val Arg Thr Ile Ala Met 
    50                  55                  60                  

Ala Ser Thr Asp Gly Leu Ile Arg Gly Met Glu Val Ile Asp Thr Gly 
65                  70                  75                  80  

Ala Pro Ile Ser Val Pro Val Gly Glu Val Thr Leu Gly Arg Val Phe 
                85                  90                  95      

Asn Val Leu Gly Glu Pro Ile Asp Leu Glu Gly Asp Ile Pro Ala Asp 
            100                 105                 110         

Ala Arg Arg Asp Pro Ile His Arg Pro Ala Pro Lys Phe Glu Glu Leu 
        115                 120                 125             

Ala Thr Glu Val Glu Ile Leu Glu Thr Gly Ile Lys Val Val Asp Leu 
    130                 135                 140                 

Leu Ala Pro Tyr Ile Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
145                 150                 155                 160 

Gly Val Gly Lys Thr Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala 
                165                 170                 175     

Gln Glu His Gly Gly Ile Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
            180                 185                 190         

Arg Glu Gly Asn Asp Leu Tyr His Glu Met Lys Asp Ser Gly Val Ile 
        195                 200                 205             

Ser Lys Thr Ala Met Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala 
    210                 215                 220                 

Arg Met Arg Val Ala Leu Thr Gly Leu Thr Met Ala Glu Tyr Phe Arg 
225                 230                 235                 240 

Asp Glu Gln Gly Gln Asp Val Leu Leu Phe Ile Asp Asn Ile Phe Arg 
                245                 250                 255     

Phe Thr Gln Ala Gly Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro 
            260                 265                 270         

Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu 
        275                 280                 285             

Gln Glu Arg Ile Thr Ser Thr Ala Lys Gly Ser Ile Thr Ser Ile Gln 
    290                 295                 300                 

Ala Ile Tyr Val Pro Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Thr 
305                 310                 315                 320 

Thr Phe Ser His Leu Asp Ala Thr Thr Asn Leu Glu Arg Lys Leu Ala 
                325                 330                 335     

Glu Met Gly Ile Tyr Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg 
            340                 345                 350         

Ala Leu Ala Pro Glu Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg 
        355                 360                 365             

Lys Val Gln Gln Thr Leu Gln Arg Tyr Lys Glu Leu Gln Asp Ile Ile 
    370                 375                 380                 

Ala Ile Leu Gly Met Asp Glu Leu Ser Asp Glu Asp Lys Leu Val Val 
385                 390                 395                 400 

His Arg Ala Arg Arg Ile Gln Phe Phe Leu Ser Gln Asn Phe His Val 
                405                 410                 415     

Ala Glu Gln Phe Thr Gly Gln Pro Gly Ser Tyr Val Pro Val Lys Glu 
            420                 425                 430         

Thr Val Arg Gly Phe Lys Glu Ile Leu Glu Gly Lys Tyr Asp His Leu 
        435                 440                 445             

Pro Glu Asp Ala Phe Arg Leu Val Gly Arg Ile Glu Glu Val Val Glu 
    450                 455                 460                 

Lys Ala Lys Ala Met Gly 
465                 470 

<210>   941
<211>   470
<212>   PRT
<213>   Bacillus caldotenax

<400>   941
Met Thr Arg Gly Arg Val Ile Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Lys Phe Glu Asn Gly His Leu Pro Ala Ile Tyr Asn Ala Leu Lys Ile 
            20                  25                  30          

Gln His Lys Ala Arg Asn Glu Asn Glu Val Asp Ile Asp Leu Thr Leu 
        35                  40                  45              

Glu Val Ala Leu His Leu Gly Asp Asp Thr Val Arg Thr Ile Ala Met 
    50                  55                  60                  

Ala Ser Thr Asp Gly Leu Ile Arg Gly Met Glu Val Ile Asp Thr Gly 
65                  70                  75                  80  

Ala Pro Ile Ser Val Pro Val Gly Glu Val Thr Leu Gly Arg Val Phe 
                85                  90                  95      

Asn Val Leu Gly Glu Pro Ile Asp Leu Glu Gly Asp Ile Pro Ala Asp 
            100                 105                 110         

Ala Arg Arg Asp Pro Ile His Arg Pro Ala Pro Lys Phe Glu Glu Leu 
        115                 120                 125             

Ala Thr Glu Val Glu Ile Leu Glu Thr Gly Ile Lys Val Val Asp Leu 
    130                 135                 140                 

Leu Ala Pro Tyr Ile Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
145                 150                 155                 160 

Gly Val Gly Lys Thr Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala 
                165                 170                 175     

Gln Glu His Gly Gly Ile Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
            180                 185                 190         

Arg Glu Gly Asn Asp Leu Tyr His Glu Met Lys Asp Ser Gly Val Ile 
        195                 200                 205             

Ser Lys Thr Ala Met Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala 
    210                 215                 220                 

Arg Met Arg Val Ala Leu Thr Gly Leu Thr Met Ala Glu Tyr Phe Arg 
225                 230                 235                 240 

Asp Glu Gln Gly Gln Asp Val Leu Leu Phe Ile Asp Asn Ile Phe Arg 
                245                 250                 255     

Phe Thr Gln Ala Gly Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro 
            260                 265                 270         

Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu 
        275                 280                 285             

Gln Glu Arg Ile Thr Ser Thr Ala Lys Gly Ser Thr Thr Ser Ile Gln 
    290                 295                 300                 

Ala Ile Tyr Val Pro Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Thr 
305                 310                 315                 320 

Thr Phe Ser His Leu Asp Ala Thr Thr Asn Leu Glu Arg Asn Val Ala 
                325                 330                 335     

Glu Met Gly Ile Tyr Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg 
            340                 345                 350         

Ala Leu Ala Pro Glu Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg 
        355                 360                 365             

Lys Val Gln Gln Thr Leu Gln Arg Tyr Lys Glu Leu Gln Asp Ile Ile 
    370                 375                 380                 

Ala Ile Leu Gly Met Asp Glu Leu Ser Asp Glu Asp Lys Leu Val Val 
385                 390                 395                 400 

His Arg Ala Arg Arg Ile Gln Phe Phe Leu Ser Gln Asn Phe His Val 
                405                 410                 415     

Ala Glu Gln Phe Thr Gly Gln Pro Gly Ser Tyr Val Pro Val Lys Glu 
            420                 425                 430         

Thr Val Arg Gly Phe Lys Glu Ile Leu Glu Gly Lys Tyr Asp His Leu 
        435                 440                 445             

Pro Glu Asp Arg Phe Arg Leu Val Gly Arg Ile Glu Glu Val Val Glu 
    450                 455                 460                 

Lys Ala Lys Ala Met Gly 
465                 470 

<210>   942
<211>   470
<212>   PRT
<213>   ATPase beta F1 Score: 674 Significance: 0.0 Identities: 344/470 Positives: 391/470 Gaps: 5/470

<400>   942
Met Thr Arg Gly Arg Val Ile Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Lys Phe Glu Asn Gly His Leu Pro Ala Ile Tyr Asn Ala Leu Lys Ile 
            20                  25                  30          

Gln His Lys Ala Arg Asn Glu Asn Glu Val Asp Ile Asp Leu Thr Leu 
        35                  40                  45              

Glu Val Ala Leu His Leu Gly Asp Asp Thr Val Arg Thr Ile Ala Met 
    50                  55                  60                  

Ala Ser Thr Asp Gly Leu Ile Arg Gly Met Glu Val Ile Asp Thr Gly 
65                  70                  75                  80  

Ala Pro Ile Ser Val Pro Val Gly Gln Val Thr Leu Gly Arg Val Phe 
                85                  90                  95      

Asn Val Leu Gly Glu Pro Ile Asp Leu Glu Gly Asp Ile Pro Ala Asp 
            100                 105                 110         

Ala Arg Arg Asp Pro Ile His Arg Pro Ala Pro Lys Phe Glu Glu Leu 
        115                 120                 125             

Ala Thr Glu Val Glu Ile Leu Glu Thr Gly Ile Lys Val Val Asp Leu 
    130                 135                 140                 

Leu Ala Pro Tyr Ile Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
145                 150                 155                 160 

Gly Asp Gly Lys Thr Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala 
                165                 170                 175     

Gln Glu His Gly Gly Ile Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
            180                 185                 190         

Arg Glu Gly Asn Asp Leu Tyr His Glu Met Lys Asp Ser Gly Val Ile 
        195                 200                 205             

Ser Lys Thr Ala Met Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala 
    210                 215                 220                 

Arg Met Arg Val Ala Leu Thr Gly Leu Thr Met Ala Glu Tyr Phe Arg 
225                 230                 235                 240 

Asp Glu Gln Gly Gln Asp Val Leu Leu Phe Ile Asp Asn Ile Phe Arg 
                245                 250                 255     

Phe Thr Gln Ala Gly Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro 
            260                 265                 270         

Ser Ala Ile Gly Tyr Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu 
        275                 280                 285             

Gln Glu Arg Ile Thr Ser Thr Ala Lys Gly Ser Ile Thr Ser Ile Gln 
    290                 295                 300                 

Ala Ile Tyr Val Pro Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Thr 
305                 310                 315                 320 

Thr Phe Ser His Leu Asp Ala Thr Thr Asn Leu Glu Arg Lys Leu Ala 
                325                 330                 335     

Glu Met Gly Ile Tyr Pro Ala Val Asp Pro Leu Val Ser Thr Ser Arg 
            340                 345                 350         

Ala Leu Ala Pro Glu Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg 
        355                 360                 365             

Lys Val Gln Gln Thr Leu Glu Arg Tyr Lys Glu Leu Gln Asp Ile Ile 
    370                 375                 380                 

Ala Ile Leu Gly Met Asp Glu Leu Ser Asp Glu Asp Lys Leu Val Val 
385                 390                 395                 400 

His Arg Ala Arg Arg Ile Gln Phe Phe Leu Ser Gln Asn Phe His Val 
                405                 410                 415     

Ala Glu Gln Phe Thr Gly Gln Pro Gly Ser Tyr Val Pro Val Lys Glu 
            420                 425                 430         

Thr Val Arg Gly Phe Lys Glu Ile Leu Glu Gly Lys Tyr Asp His Leu 
        435                 440                 445             

Pro Glu Asp Arg Phe Arg Leu Val Gly Arg Ile Glu Glu Val Val Glu 
    450                 455                 460                 

Lys Ala Lys Ala Met Gly 
465                 470 

<210>   943
<211>   467
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 936

<400>   943
Met Asn Lys Gly Tyr Val Val Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Arg Phe Pro Glu Gly Gln Leu Pro Ala Ile Asn Asn Ala Leu Arg Ile 
            20                  25                  30          

Asp Tyr Glu Gly Asp Leu Pro Val His Leu Thr Leu Glu Val Ala Leu 
        35                  40                  45              

His Leu Gly Asp Asn Val Val Arg Thr Ile Ala Met Ser Ser Thr Asp 
    50                  55                  60                  

Gly Leu Val Arg Gly Val Glu Val Val Asp Thr Gly Gln Pro Ile Ser 
65                  70                  75                  80  

Met Pro Val Gly Pro Gly Thr Leu Gly Arg Ile Phe Asn Val Leu Gly 
                85                  90                  95      

Glu Thr Ile Asp Glu Arg Gly Pro Val Glu Ala Pro Glu Arg Trp Pro 
            100                 105                 110         

Ile His Arg Pro Ala Pro Ala Phe Gly Asp Leu Thr Thr Lys Thr Glu 
        115                 120                 125             

Ile Phe Glu Thr Gly Ile Lys Val Val Asp Leu Leu Ala Pro Tyr Val 
    130                 135                 140                 

Lys Gly Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr 
145                 150                 155                 160 

Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala Lys Glu His Gly Gly 
                165                 170                 175     

Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp 
            180                 185                 190         

Leu Tyr His Glu Met Lys Glu Ser Gly Val Leu Asp Lys Thr Cys Met 
        195                 200                 205             

Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Leu Arg Val Ala 
    210                 215                 220                 

Leu Ser Gly Leu Thr Leu Ala Glu Tyr Phe Arg Asp Val Glu Gln Arg 
225                 230                 235                 240 

Asp Val Leu Phe Phe Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly 
                245                 250                 255     

Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro Ser Ala Val Gly Tyr 
            260                 265                 270         

Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu Gln Glu Arg Ile Ala 
        275                 280                 285             

Ser Thr Val Arg Gly Ser Ile Thr Ser Ile Gln Ala Val Tyr Val Pro 
    290                 295                 300                 

Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Asn Thr Phe Thr His Leu 
305                 310                 315                 320 

Asp Ala Thr Thr Val Leu Glu Arg Arg Ile Ala Asp Met Gly Leu Tyr 
                325                 330                 335     

Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg Ala Leu Gln Pro Asp 
            340                 345                 350         

Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg Gly Val Gln Ala Val 
        355                 360                 365             

Leu Gln Arg Tyr Arg Glu Leu Gln Asp Ile Ile Ala Ile Leu Gly Met 
    370                 375                 380                 

Asp Glu Leu Thr Asp Glu Asp Arg Leu Ile Val Ser Arg Ala Arg Lys 
385                 390                 395                 400 

Ile Gln Asn Phe Leu Ser Gln Pro Phe Phe Val Ala Glu Val Phe Thr 
                405                 410                 415     

Gly Thr Pro Gly Lys Tyr Val Pro Val Lys Asp Thr Val Arg Ser Phe 
            420                 425                 430         

Lys Glu Ile Leu Glu Gly Lys His Asp Asp Ile Pro Glu Thr Tyr Phe 
        435                 440                 445             

Arg Tyr Cys Gly Ala Ile Glu Asp Val Ile Glu Lys Ala Arg Lys Asp 
    450                 455                 460                 

Gly Tyr Ala 
465         

<210>   944
<211>   467
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 936

<400>   944
Met Asn Lys Gly Tyr Val Val Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Arg Phe Pro Glu Gly Gln Leu Pro Ala Ile Asn Asn Ala Leu Arg Ile 
            20                  25                  30          

Asp Tyr Glu Gly Asp Leu Pro Val His Leu Thr Leu Glu Val Ala Leu 
        35                  40                  45              

His Leu Gly Asp Asn Val Val Arg Thr Ile Ala Met Ser Ser Thr Asp 
    50                  55                  60                  

Gly Leu Val Arg Gly Val Glu Val Val Asp Thr Gly Asn Pro Ile Ser 
65                  70                  75                  80  

Met Pro Val Gly Pro Gly Thr Leu Gly Arg Ile Phe Asn Val Leu Gly 
                85                  90                  95      

Glu Thr Ile Asp Glu Arg Gly Pro Val Asp Ala Pro Glu Arg Trp Pro 
            100                 105                 110         

Ile His Arg Pro Ala Pro Ala Phe Gly Asp Leu Thr Thr Lys Thr Glu 
        115                 120                 125             

Ile Phe Glu Thr Gly Ile Lys Val Val Asp Leu Leu Ala Pro Tyr Val 
    130                 135                 140                 

Lys Gly Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr 
145                 150                 155                 160 

Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala Lys Glu His Gly Gly 
                165                 170                 175     

Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp 
            180                 185                 190         

Leu Tyr His Glu Met Lys Glu Ser Gly Val Leu Asp Lys Thr Cys Met 
        195                 200                 205             

Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Leu Arg Val Ala 
    210                 215                 220                 

Leu Ser Gly Leu Thr Leu Ala Glu Tyr Phe Arg Asp Val Glu Gln Arg 
225                 230                 235                 240 

Asp Val Leu Phe Phe Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly 
                245                 250                 255     

Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro Ser Ala Val Gly Tyr 
            260                 265                 270         

Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu Gln Glu Arg Ile Ala 
        275                 280                 285             

Ser Thr Val Arg Gly Ser Ile Thr Ser Ile Gln Ala Val Tyr Val Pro 
    290                 295                 300                 

Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Asn Thr Phe Thr His Leu 
305                 310                 315                 320 

Asp Ala Thr Thr Val Leu Glu Arg Arg Ile Ala Asp Met Gly Leu Tyr 
                325                 330                 335     

Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg Ala Leu Gln Pro Asp 
            340                 345                 350         

Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg Gly Val Gln Ala Val 
        355                 360                 365             

Leu Gln Arg Tyr Arg Glu Leu Gln Asp Ile Ile Ala Ile Leu Gly Met 
    370                 375                 380                 

Asp Glu Leu Thr Asp Glu Asp Arg Leu Ile Val Ser Arg Ala Arg Lys 
385                 390                 395                 400 

Ile Gln Asn Phe Leu Ser Gln Pro Phe Phe Val Ala Glu Val Phe Thr 
                405                 410                 415     

Gly Thr Pro Gly Lys Tyr Val Pro Val Lys Asp Thr Val Arg Ser Phe 
            420                 425                 430         

Lys Glu Ile Leu Glu Gly Lys His Asp Asp Ile Pro Glu Thr Tyr Phe 
        435                 440                 445             

Arg Tyr Cys Gly Ala Ile Glu Asp Val Ile Glu Lys Ala Arg Lys Asp 
    450                 455                 460                 

Gly Tyr Ala 
465         

<210>   945
<211>   467
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 936

<400>   945
Met Asn Lys Gly Tyr Val Val Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Arg Phe Pro Glu Gly Gln Leu Pro Ala Ile Asn Asn Ala Leu Arg Ile 
            20                  25                  30          

Asp Tyr Glu Gly Asp Leu Pro Val His Leu Thr Leu Glu Val Ala Leu 
        35                  40                  45              

His Leu Gly Asp Asn Val Val Arg Thr Ile Ala Met Ser Ser Thr Asp 
    50                  55                  60                  

Gly Leu Val Arg Gly Val Glu Val Val Asp Thr Gly Gln Pro Ile Ser 
65                  70                  75                  80  

Met Pro Val Gly Pro Gly Thr Leu Gly Arg Ile Phe Asn Val Leu Gly 
                85                  90                  95      

Glu Thr Ile Asp Glu Arg Gly Pro Val Asp Ala Pro Glu Arg Trp Pro 
            100                 105                 110         

Ile His Arg Pro Ala Pro Ala Phe Gly Asp Leu Thr Thr Lys Thr Glu 
        115                 120                 125             

Ile Phe Glu Thr Gly Ile Lys Val Val Asp Leu Leu Ala Pro Tyr Ile 
    130                 135                 140                 

Lys Gly Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr 
145                 150                 155                 160 

Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala Lys Glu His Gly Gly 
                165                 170                 175     

Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp 
            180                 185                 190         

Leu Tyr His Glu Met Lys Glu Ser Gly Val Leu Asp Lys Thr Cys Met 
        195                 200                 205             

Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Leu Arg Val Ala 
    210                 215                 220                 

Leu Ser Gly Leu Thr Leu Ala Glu Tyr Phe Arg Asp Val Glu Gln Arg 
225                 230                 235                 240 

Asp Val Leu Phe Phe Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly 
                245                 250                 255     

Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro Ser Ala Val Gly Tyr 
            260                 265                 270         

Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu Gln Glu Arg Ile Ala 
        275                 280                 285             

Ser Thr Val Arg Gly Ser Ile Thr Ser Ile Gln Ala Val Tyr Val Pro 
    290                 295                 300                 

Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Asn Thr Phe Thr His Leu 
305                 310                 315                 320 

Asp Ala Thr Thr Val Leu Glu Arg Arg Ile Ala Asp Met Gly Leu Tyr 
                325                 330                 335     

Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg Ala Leu Gln Pro Asp 
            340                 345                 350         

Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg Gly Val Gln Ala Val 
        355                 360                 365             

Leu Gln Arg Tyr Arg Glu Leu Gln Asp Ile Ile Ala Ile Leu Gly Met 
    370                 375                 380                 

Asp Glu Leu Thr Asp Glu Asp Arg Leu Ile Val Ser Arg Ala Arg Lys 
385                 390                 395                 400 

Ile Gln Asn Phe Leu Ser Gln Pro Phe Phe Val Ala Glu Val Phe Thr 
                405                 410                 415     

Gly Thr Pro Gly Lys Tyr Val Pro Val Lys Asp Thr Val Arg Ser Phe 
            420                 425                 430         

Lys Glu Ile Leu Glu Gly Lys His Asp Asp Ile Pro Glu Thr Tyr Phe 
        435                 440                 445             

Arg Tyr Cys Gly Ala Ile Glu Asp Val Ile Glu Lys Ala Arg Lys Asp 
    450                 455                 460                 

Gly Tyr Ala 
465         

<210>   946
<211>   467
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 936

<400>   946
Met Asn Lys Gly Tyr Val Val Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Arg Phe Pro Glu Gly Gln Leu Pro Ala Ile Asn Asn Ala Leu Arg Ile 
            20                  25                  30          

Asp Tyr Glu Gly Asp Leu Pro Val His Leu Thr Leu Glu Val Ala Leu 
        35                  40                  45              

His Leu Gly Asp Asn Val Val Arg Thr Ile Ala Met Ser Ser Thr Asp 
    50                  55                  60                  

Gly Leu Val Arg Gly Val Glu Val Val Asp Thr Gly Gln Pro Ile Ser 
65                  70                  75                  80  

Met Pro Val Gly Pro Gly Thr Leu Gly Arg Ile Phe Asn Val Leu Gly 
                85                  90                  95      

Glu Thr Ile Asp Glu Arg Gly Pro Val Asp Ala Pro Glu Arg Trp Pro 
            100                 105                 110         

Ile His Arg Pro Ala Pro Ala Phe Gly Asp Leu Thr Thr Lys Thr Glu 
        115                 120                 125             

Ile Phe Glu Thr Gly Ile Lys Val Val Asp Leu Leu Ala Pro Tyr Val 
    130                 135                 140                 

Lys Gly Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr 
145                 150                 155                 160 

Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala Lys Glu His Gly Gly 
                165                 170                 175     

Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp 
            180                 185                 190         

Leu Tyr His Glu Met Lys Glu Ser Gly Val Leu Asp Lys Thr Cys Met 
        195                 200                 205             

Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Leu Arg Val Ala 
    210                 215                 220                 

Leu Ser Gly Leu Thr Leu Ala Glu Tyr Phe Arg Asp Val Glu Gln Arg 
225                 230                 235                 240 

Asp Val Leu Phe Phe Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly 
                245                 250                 255     

Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro Ser Ala Val Gly Tyr 
            260                 265                 270         

Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu Gln Glu Arg Ile Ala 
        275                 280                 285             

Ser Thr Val Arg Gly Ser Ile Thr Ser Ile Gln Ala Val Tyr Val Pro 
    290                 295                 300                 

Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Asn Thr Phe Thr His Leu 
305                 310                 315                 320 

Asp Ala Thr Thr Val Leu Glu Arg Arg Ile Ala Asp Met Gly Leu Tyr 
                325                 330                 335     

Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg Ala Leu Gln Pro Asp 
            340                 345                 350         

Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg Gly Val Gln Ala Val 
        355                 360                 365             

Leu Gln Arg Tyr Arg Glu Leu Gln Asp Ile Ile Ala Ile Leu Gly Met 
    370                 375                 380                 

Asp Glu Leu Thr Asp Glu Asp Arg Leu Ile Val Ser Arg Ala Arg Lys 
385                 390                 395                 400 

Ile Gln Asn Phe Leu Ser Gln Pro Phe Phe Val Ala Glu Val Phe Thr 
                405                 410                 415     

Gly Thr Pro Gly Lys Tyr Val Pro Val Lys Asp Thr Val Arg Ser Phe 
            420                 425                 430         

Lys Glu Ile Leu Glu Gly Lys His Asp Asp Ile Pro Glu Thr Tyr Phe 
        435                 440                 445             

Arg Tyr Cys Gly Ala Ile Glu Asp Val Ile Glu Lys Ala Arg Lys Glu 
    450                 455                 460                 

Gly Tyr Ala 
465         

<210>   947
<211>   467
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 936

<400>   947
Met Asn Lys Gly Tyr Val Val Gln Val Met Gly Pro Val Val Asp Val 
                5                   10                  15      

Arg Phe Pro Glu Gly Gln Leu Pro Ala Ile Asn Asn Ala Leu Arg Ile 
            20                  25                  30          

Asp Tyr Glu Gly Glu Leu Pro Val His Leu Thr Leu Glu Val Ala Leu 
        35                  40                  45              

His Leu Gly Asp Asn Val Val Arg Thr Ile Ala Met Ser Ser Thr Asp 
    50                  55                  60                  

Gly Leu Val Arg Gly Val Glu Val Val Asp Thr Gly Gln Pro Ile Ser 
65                  70                  75                  80  

Met Pro Val Gly Pro Gly Thr Leu Gly Arg Ile Phe Asn Val Leu Gly 
                85                  90                  95      

Glu Thr Ile Asp Glu Arg Gly Pro Val Asp Ala Pro Glu Arg Trp Pro 
            100                 105                 110         

Ile His Arg Pro Ala Pro Ala Phe Gly Asp Leu Thr Thr Lys Thr Glu 
        115                 120                 125             

Ile Phe Glu Thr Gly Ile Lys Val Val Asp Leu Leu Ala Pro Tyr Val 
    130                 135                 140                 

Lys Gly Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr 
145                 150                 155                 160 

Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala Lys Glu His Gly Gly 
                165                 170                 175     

Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp 
            180                 185                 190         

Leu Tyr His Glu Met Lys Glu Ser Gly Val Leu Asp Lys Thr Cys Met 
        195                 200                 205             

Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Leu Arg Val Ala 
    210                 215                 220                 

Leu Ser Gly Leu Thr Leu Ala Glu Tyr Phe Arg Asp Val Glu Gln Arg 
225                 230                 235                 240 

Asp Val Leu Phe Phe Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly 
                245                 250                 255     

Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro Ser Ala Val Gly Tyr 
            260                 265                 270         

Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu Gln Glu Arg Ile Ala 
        275                 280                 285             

Ser Thr Val Arg Gly Ser Ile Thr Ser Ile Gln Ala Val Tyr Val Pro 
    290                 295                 300                 

Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Asn Thr Phe Thr His Leu 
305                 310                 315                 320 

Asp Ala Thr Thr Val Leu Glu Arg Arg Ile Ala Asp Met Gly Leu Tyr 
                325                 330                 335     

Pro Ala Val Asp Pro Leu Ala Ser Thr Ser Arg Ala Leu Gln Pro Asp 
            340                 345                 350         

Ile Val Gly Glu Glu His Tyr Gln Val Ala Arg Gly Val Gln Ala Val 
        355                 360                 365             

Leu Gln Arg Tyr Arg Glu Leu Gln Asp Ile Ile Ala Ile Leu Gly Met 
    370                 375                 380                 

Asp Glu Leu Thr Asp Glu Asp Arg Leu Ile Val Ser Arg Ala Arg Lys 
385                 390                 395                 400 

Ile Gln Asn Phe Leu Ser Gln Pro Phe Phe Val Ala Glu Val Phe Thr 
                405                 410                 415     

Gly Thr Pro Gly Lys Tyr Val Pro Val Lys Asp Thr Val Arg Ser Phe 
            420                 425                 430         

Lys Glu Ile Leu Glu Gly Lys His Asp Asp Ile Pro Glu Thr Tyr Phe 
        435                 440                 445             

Arg Tyr Cys Gly Ala Ile Glu Asp Val Ile Glu Lys Ala Arg Lys Asp 
    450                 455                 460                 

Gly Tyr Ala 
465         

<210>   948
<211>   1404
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 937

<400>   948
gtgaacaaag ggtatgtagt gcaggtcatg ggcccggtgg tcgatgtccg ctttccagaa       60

ggacaactgc cggcgatcaa caacgccctc cgcattgatt acgagggcga tctgcccgtg      120

catctgacgc tcgaggtggc gctgcacctc ggagacaacg tggttcgaac catcgcgatg      180

tcgtcgacgg acgggctcgt ccgcggcgtc gaagtcgtcg atacagggca gcccatctcg      240

atgcccgtag gaccgggcac cctggggcgc atcttcaacg tgctcggcga gacgattgac      300

gagagggggc ccgtcgaagc cccggagcgc tggccgatcc accgtcccgc gcccgcgttt      360

ggggatctga cgacgaagac cgagatcttc gaaaccggca tcaaggtcgt ggatctgctc      420

gctccgtacg tcaagggcgg taaggttggc ctgttcggcg gcgcgggcgt cggcaaaacg      480

gtgctcattc aggagctcat tcacaacatc gcgaaggagc acggcggtta ttcggtgttc      540

gccggcgtcg gcgagcggac gcgcgagggt aacgacctct accatgaaat gaaggagtcg      600

ggcgtcctcg acaagacgtg catggtgttc ggccagatga acgagccgcc cggtgcgcgc      660

ctccgcgtgg cgctgtccgg cctgacgctc gctgagtact tccgcgatgt ggagcagcgc      720

gacgtcctgt tcttcatcga caacatcttc cgcttcacac aggcgggttc cgaggtgtct      780

gcgcttctcg gccgcatgcc gtcggccgtc ggttaccagc ccaccctggc cacggaaatg      840

ggccaactgc aggaacgcat tgcctcgacg gtgcgagggt ccatcacgtc catccaggcg      900

gtgtacgtgc cggcggacga ctacaccgat ccggcgccgg ccaacacgtt cacccacctc      960

gatgccacga ccgtgttgga gcgccggatc gccgacatgg gcctgtatcc ggcggtcgat     1020

ccgctcgctt cgacgtcgcg ggcgctccag cctgacatcg tgggtgagga gcactatcag     1080

gtggcgcgtg gcgtccaagc ggtgctgcag cggtatcgcg agctgcagga catcatcgcc     1140

atcctcggca tggacgagct gacggatgag gaccgcctca tcgtgtcgcg cgcgcgcaaa     1200

atccagaact tcctgtcgca gccgttcttc gtcgctgagg tgttcaccgg gacgccgggc     1260

aagtacgtgc cggtgaagga taccgtgcgc tcgttcaagg agatcctgga gggcaagcac     1320

gacgacattc cggagacgta cttccgctac tgcggcgcga ttgaagacgt gatcgagaag     1380

gcgcgcaagg acggctacgc ctga                                            1404


<210>   949
<211>   1404
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 937

<400>   949
gtgaacaaag ggtatgtagt gcaggtcatg ggcccggtgg tcgatgtccg ctttccagaa       60

ggacaactgc cggcgatcaa caacgccctc cgcattgatt acgagggcga tctgcccgtg      120

catctgacgc tcgaggtggc gctgcacctc ggagacaacg tggttcgaac catcgcgatg      180

tcgtcgacgg acgggctcgt ccgcggcgtc gaagtcgtcg atacagggaa tcccatctcg      240

atgcccgtag gaccgggcac cctggggcgc atcttcaacg tgctcggcga gacgattgac      300

gagagggggc ccgtcgatgc cccggagcgc tggccgatcc accgtcccgc gcccgcgttt      360

ggggatctga cgacgaagac cgagatcttc gaaaccggca tcaaggtcgt ggatctgctc      420

gctccgtacg tcaagggcgg taaggttggc ctgttcggcg gcgcgggcgt cggcaaaacg      480

gtgctcattc aggagctcat tcacaacatc gcgaaggagc acggcggtta ttcggtgttc      540

gccggcgtcg gcgagcggac gcgcgagggt aacgacctct accatgaaat gaaggagtcg      600

ggcgtcctcg acaagacgtg catggtgttc ggccagatga acgagccgcc cggtgcgcgc      660

ctccgcgtgg cgctgtccgg cctgacgctc gctgagtact tccgcgatgt ggagcagcgc      720

gacgtcctgt tcttcatcga caacatcttc cgcttcacac aggcgggttc cgaggtgtct      780

gcgcttctcg gccgcatgcc gtcggccgtc ggttaccagc ccaccctggc cacggaaatg      840

ggccaactgc aggaacgcat tgcctcgacg gtgcgagggt ccatcacgtc catccaggcg      900

gtgtacgtgc cggcggacga ctacaccgat ccggcgccgg ccaacacgtt cacccacctc      960

gatgccacga ccgtgttgga gcgccggatc gccgacatgg gcctgtatcc ggcggtcgat     1020

ccgctcgctt cgacgtcgcg ggcgctccag cctgacatcg tgggtgagga gcactatcag     1080

gtggcgcgtg gcgtccaagc ggtgctgcag cggtatcgcg agctgcagga catcatcgcc     1140

atcctcggca tggacgagct gacggatgag gaccgcctca tcgtgtcgcg cgcgcgcaaa     1200

atccagaact tcctgtcgca gccgttcttc gtcgctgagg tgttcaccgg gacgccgggc     1260

aagtacgtgc cggtgaagga taccgtgcgc tcgttcaagg agatcctgga gggcaagcac     1320

gacgacattc cggagacgta cttccgctac tgcggcgcga ttgaagacgt gatcgagaag     1380

gcgcgcaagg acggctacgc ctga                                            1404


<210>   950
<211>   1404
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 937

<400>   950
gtgaacaaag ggtatgtagt gcaggtcatg ggcccggtgg tcgatgtccg ctttccagaa       60

ggacaactgc cggcgatcaa caacgccctc cgcattgatt acgagggcga tctgcccgtg      120

catctgacgc tcgaggtggc gctgcacctc ggagacaacg tggttcgaac catcgcgatg      180

tcgtcgacgg acgggctcgt ccgcggcgtc gaagtcgtcg atacagggca gcccatctcg      240

atgcccgtag gaccgggcac cctggggcgc atcttcaacg tgctcggcga gacgattgac      300

gagagggggc ccgtcgatgc cccggagcgc tggccgatcc accgtcccgc gcccgcgttt      360

ggggatctga cgacgaagac cgagatcttc gaaaccggca tcaaggtcgt ggatctgctc      420

gctccgtaca ttaagggcgg taaggttggc ctgttcggcg gcgcgggcgt cggcaaaacg      480

gtgctcattc aggagctcat tcacaacatc gcgaaggagc acggcggtta ttcggtgttc      540

gccggcgtcg gcgagcggac gcgcgagggt aacgacctct accatgaaat gaaggagtcg      600

ggcgtcctcg acaagacgtg catggtgttc ggccagatga acgagccgcc cggtgcgcgc      660

ctccgcgtgg cgctgtccgg cctgacgctc gctgagtact tccgcgatgt ggagcagcgc      720

gacgtcctgt tcttcatcga caacatcttc cgcttcacac aggcgggttc cgaggtgtct      780

gcgcttctcg gccgcatgcc gtcggccgtc ggttaccagc ccaccctggc cacggaaatg      840

ggccaactgc aggaacgcat tgcctcgacg gtgcgagggt ccatcacgtc catccaggcg      900

gtgtacgtgc cggcggacga ctacaccgat ccggcgccgg ccaacacgtt cacccacctc      960

gatgccacga ccgtgttgga gcgccggatc gccgacatgg gcctgtatcc ggcggtcgat     1020

ccgctcgctt cgacgtcgcg ggcgctccag cctgacatcg tgggtgagga gcactatcag     1080

gtggcgcgtg gcgtccaagc ggtgctgcag cggtatcgcg agctgcagga catcatcgcc     1140

atcctcggca tggacgagct gacggatgag gaccgcctca tcgtgtcgcg cgcgcgcaaa     1200

atccagaact tcctgtcgca gccgttcttc gtcgctgagg tgttcaccgg gacgccgggc     1260

aagtacgtgc cggtgaagga taccgtgcgc tcgttcaagg agatcctgga gggcaagcac     1320

gacgacattc cggagacgta cttccgctac tgcggcgcga ttgaagacgt gatcgagaag     1380

gcgcgcaagg acggctacgc ctga                                            1404


<210>   951
<211>   1404
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 937

<400>   951
gtgaacaaag ggtatgtagt gcaggtcatg ggcccggtgg tcgatgtccg ctttccagaa       60

ggacaactgc cggcgatcaa caacgccctc cgcattgatt acgagggcga tctgcccgtg      120

catctgacgc tcgaggtggc gctgcacctc ggagacaacg tggttcgaac catcgcgatg      180

tcgtcgacgg acgggctcgt ccgcggcgtc gaagtcgtcg atacagggca gcccatctcg      240

atgcccgtag gaccgggcac cctggggcgc atcttcaacg tgctcggcga gacgattgac      300

gagagggggc ccgtcgatgc cccggagcgc tggccgatcc accgtcccgc gcccgcgttt      360

ggggatctga cgacgaagac cgagatcttc gaaaccggca tcaaggtcgt ggatctgctc      420

gctccgtacg tcaagggcgg taaggttggc ctgttcggcg gcgcgggcgt cggcaaaacg      480

gtgctcattc aggagctcat tcacaacatc gcgaaggagc acggcggtta ttcggtgttc      540

gccggcgtcg gcgagcggac gcgcgagggt aacgacctct accatgaaat gaaggagtcg      600

ggcgtcctcg acaagacgtg catggtgttc ggccagatga acgagccgcc cggtgcgcgc      660

ctccgcgtgg cgctgtccgg cctgacgctc gctgagtact tccgcgatgt ggagcagcgc      720

gacgtcctgt tcttcatcga caacatcttc cgcttcacac aggcgggttc cgaggtgtct      780

gcgcttctcg gccgcatgcc gtcggccgtc ggttaccagc ccaccctggc cacggaaatg      840

ggccaactgc aggaacgcat tgcctcgacg gtgcgagggt ccatcacgtc catccaggcg      900

gtgtacgtgc cggcggacga ctacaccgat ccggcgccgg ccaacacgtt cacccacctc      960

gatgccacga ccgtgttgga gcgccggatc gccgacatgg gcctgtatcc ggcggtcgat     1020

ccgctcgctt cgacgtcgcg ggcgctccag cctgacatcg tgggtgagga gcactatcag     1080

gtggcgcgtg gcgtccaagc ggtgctgcag cggtatcgcg agctgcagga catcatcgcc     1140

atcctcggca tggacgagct gacggatgag gaccgcctca tcgtgtcgcg cgcgcgcaaa     1200

atccagaact tcctgtcgca gccgttcttc gtcgctgagg tgttcaccgg gacgccgggc     1260

aagtacgtgc cggtgaagga taccgtgcgc tcgttcaagg agatcctgga gggcaagcac     1320

gacgacattc cggagacgta cttccgctac tgcggcgcga ttgaagacgt gatcgagaag     1380

gcgcgcaagg aaggctacgc ctga                                            1404


<210>   952
<211>   1404
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 937

<400>   952
gtgaacaaag ggtatgtagt gcaggtcatg ggcccggtgg tcgatgtccg ctttccagaa       60

ggacaactgc cggcgatcaa caacgccctc cgcattgatt acgagggcga actgcccgtg      120

catctgacgc tcgaggtggc gctgcacctc ggagacaacg tggttcgaac catcgcgatg      180

tcgtcgacgg acgggctcgt ccgcggcgtc gaagtcgtcg atacagggca gcccatctcg      240

atgcccgtag gaccgggcac cctggggcgc atcttcaacg tgctcggcga gacgattgac      300

gagagggggc ccgtcgatgc cccggagcgc tggccgatcc accgtcccgc gcccgcgttt      360

ggggatctga cgacgaagac cgagatcttc gaaaccggca tcaaggtcgt ggatctgctc      420

gctccgtacg tcaagggcgg taaggttggc ctgttcggcg gcgcgggcgt cggcaaaacg      480

gtgctcattc aggagctcat tcacaacatc gcgaaggagc acggcggtta ttcggtgttc      540

gccggcgtcg gcgagcggac gcgcgagggt aacgacctct accatgaaat gaaggagtcg      600

ggcgtcctcg acaagacgtg catggtgttc ggccagatga acgagccgcc cggtgcgcgc      660

ctccgcgtgg cgctgtccgg cctgacgctc gctgagtact tccgcgatgt ggagcagcgc      720

gacgtcctgt tcttcatcga caacatcttc cgcttcacac aggcgggttc cgaggtgtct      780

gcgcttctcg gccgcatgcc gtcggccgtc ggttaccagc ccaccctggc cacggaaatg      840

ggccaactgc aggaacgcat tgcctcgacg gtgcgagggt ccatcacgtc catccaggcg      900

gtgtacgtgc cggcggacga ctacaccgat ccggcgccgg ccaacacgtt cacccacctc      960

gatgccacga ccgtgttgga gcgccggatc gccgacatgg gcctgtatcc ggcggtcgat     1020

ccgctcgctt cgacgtcgcg ggcgctccag cctgacatcg tgggtgagga gcactatcag     1080

gtggcgcgtg gcgtccaagc ggtgctgcag cggtatcgcg agctgcagga catcatcgcc     1140

atcctcggca tggacgagct gacggatgag gaccgcctca tcgtgtcgcg cgcgcgcaaa     1200

atccagaact tcctgtcgca gccgttcttc gtcgctgagg tgttcaccgg gacgccgggc     1260

aagtacgtgc cggtgaagga taccgtgcgc tcgttcaagg agatcctgga gggcaagcac     1320

gacgacattc cggagacgta cttccgctac tgcggcgcga ttgaagacgt gatcgagaag     1380

gcgcgcaagg acggctacgc ctga                                            1404


<210>   953
<211>   904
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   953
Met Gly Ala Asn Leu Phe Gln Ala Lys Gln Thr Leu Thr Val Gly Gly 
                5                   10                  15      

Lys Ser Tyr Thr Tyr Tyr Arg Leu Asp Ala Leu Gln Glu Gln Gly Val 
            20                  25                  30          

Ala Asp Ile Ser Arg Leu Pro Ile Ser Ile Lys Ile Leu Leu Glu Ser 
        35                  40                  45              

Val Leu Arg Gln Tyr Asp Gly Arg Val Ile Thr Glu Glu His Val Arg 
    50                  55                  60                  

Glu Leu Ala Asn Trp Asn Ala Ala Asn Pro Ala Lys Ser Glu Val Pro 
65                  70                  75                  80  

Phe Lys Pro Ala Arg Ile Leu Leu Gln Asp Phe Thr Gly Val Pro Val 
                85                  90                  95      

Val Val Asp Leu Ala Ala Met Arg Thr Ala Met His Lys Leu Gly Gly 
            100                 105                 110         

Asn Pro Lys Arg Ile Asn Pro Leu Ile Pro Val Asp Leu Val Ile Asp 
        115                 120                 125             

His Ser Val Gln Val Asp Ala Phe Gly Ser Lys Glu Ala Leu Glu Phe 
    130                 135                 140                 

Asn Ile Ala Lys Glu Phe Glu Arg Asn Glu Glu Arg Tyr Arg Phe Leu 
145                 150                 155                 160 

Arg Trp Ala Gln Thr Ala Phe Asp Asn Phe Arg Ala Val Pro Pro Gly 
                165                 170                 175     

Met Gly Ile Val His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val 
            180                 185                 190         

Gln Glu Arg Thr Val Asp Gly Glu Gln Val Val Phe Pro Asp Ser Leu 
        195                 200                 205             

Val Gly Thr Asp Ser His Thr Thr Met Ile Asn Gly Val Gly Val Leu 
    210                 215                 220                 

Gly Trp Gly Val Gly Gly Ile Glu Ala Glu Ala Cys Met Leu Gly Gln 
225                 230                 235                 240 

Pro Leu Tyr Phe Val Gln Pro Glu Val Ile Gly Phe Lys Leu Thr Gly 
                245                 250                 255     

Lys Leu Pro Glu Gly Ala Thr Ala Thr Asp Leu Ala Leu Thr Val Val 
            260                 265                 270         

Asn Met Leu Arg Lys Lys Gly Val Val Gly Lys Phe Val Glu Phe Tyr 
        275                 280                 285             

Gly Ala Gly Leu Ser Asn Ile Ser Val Ala Asp Arg Ala Thr Ile Ala 
    290                 295                 300                 

Asn Met Ala Pro Glu Tyr Gly Ala Thr Met Gly Phe Phe Pro Ile Asp 
305                 310                 315                 320 

Gln Ala Thr Leu Asp Tyr Leu Arg Leu Thr Gly Arg Asp Glu Ser Leu 
                325                 330                 335     

Ile Gln Leu Val Glu Ala Tyr Ala Lys Ala Gln Gly Met Phe Arg Thr 
            340                 345                 350         

Asp Asp Met Pro Asp Pro Val Phe Thr Asp Thr Leu Glu Leu Asp Leu 
        355                 360                 365             

Gly Ser Ile Gln Pro Thr Met Ala Gly Pro Lys Arg Pro Gln Asp Lys 
    370                 375                 380                 

Ile Phe Leu Ser Asp Met Lys Asn Asn Phe Glu Ala Ala Leu Glu Lys 
385                 390                 395                 400 

Pro Val Ser Glu Gly Gly Phe Gly Leu Ala Asp Gln Arg Asp Lys Thr 
                405                 410                 415     

Ala Leu Val Gln Tyr Pro Asp Gly His Lys Asp Glu Leu His His Gly 
            420                 425                 430         

Ala Val Val Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro 
        435                 440                 445             

Ser Val Met Ile Gly Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Lys 
    450                 455                 460                 

Gly Leu Lys Thr Pro Arg Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser 
465                 470                 475                 480 

Arg Val Val Thr Asp Tyr Leu Glu Arg Ser Gly Leu Leu Glu Pro Leu 
                485                 490                 495     

Ser Lys Leu Gly Phe Asp Val Val Gly Tyr Gly Cys Thr Thr Cys Ile 
            500                 505                 510         

Gly Asn Ser Gly Pro Leu Pro Glu Glu Val Ala Lys Ala Ile Gln Glu 
        515                 520                 525             

Asn Asp Leu Leu Val Ser Ala Val Leu Ser Gly Asn Arg Asn Phe Glu 
    530                 535                 540                 

Gly Arg Ile His Ser Leu Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro 
545                 550                 555                 560 

Leu Val Val Ala Tyr Ala Ile Ala Gly Thr Val Asp Ile Asp Leu Val 
                565                 570                 575     

Asn Glu Pro Ile Gly Lys Asp Glu Asn Gly Asn Asp Val Phe Leu Arg 
            580                 585                 590         

Asp Ile Trp Pro Ser Asn Glu Glu Ile Gln Ala Val Ile Arg Gln Ile 
        595                 600                 605             

Ile Asn Pro Glu Met Phe Lys Lys Glu Tyr Glu Ser Val Phe Asn Arg 
    610                 615                 620                 

Asn Glu Arg Trp Asn Lys Leu Asp Val Pro Lys Gly Glu Leu Tyr Glu 
625                 630                 635                 640 

Trp Asp Pro Asn Ser Thr Tyr Ile Gln Glu Pro Pro Phe Phe Glu Gly 
                645                 650                 655     

Leu Ser Glu Glu Val Pro Asp Ile Gln Glu Ile Gln Gly Ala Arg Val 
            660                 665                 670         

Leu Ala Tyr Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala 
        675                 680                 685             

Gly Ser Ile Ala Pro Ser Ser Pro Ala Gly Gln Tyr Leu Gln Ser Lys 
    690                 695                 700                 

Gly Val Lys Pro His Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn 
705                 710                 715                 720 

His Glu Val Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Arg Asn 
                725                 730                 735     

Lys Val Ala Pro Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Phe Pro Thr 
            740                 745                 750         

Gly Glu Val Met Pro Ile Tyr Asp Ala Ala Met Lys Tyr Lys Ala Asp 
        755                 760                 765             

Gly Thr Pro Leu Val Val Ile Ala Gly Lys Glu Tyr Gly Thr Gly Ser 
    770                 775                 780                 

Ser Arg Asp Trp Ala Ala Lys Gly Thr Tyr Leu Leu Gly Val Lys Ala 
785                 790                 795                 800 

Val Ile Ala Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Gly 
                805                 810                 815     

Met Gly Val Leu Pro Leu Glu Phe Ile Asp Gly Gln Asn Ala Glu Thr 
            820                 825                 830         

Leu Gly Leu Thr Gly Arg Glu Val Tyr Thr Ile Lys Gly Leu Ser Asn 
        835                 840                 845             

Asp Leu Lys Pro Arg Gln Thr Val Thr Val Glu Val Thr Arg Glu Asp 
    850                 855                 860                 

Gly Ser Ser Phe Thr Phe Gln Ala Leu Val Arg Leu Asp Ser Asp Ile 
865                 870                 875                 880 

Glu Val Asp Tyr Tyr Arg Asn Gly Gly Ile Leu Gln Thr Val Leu Arg 
                885                 890                 895     

Asn Phe Met Arg Glu Gln His Ala 
            900                 

<210>   954
<211>   2715
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   954
gtgggcgcca atctgtttca agccaaacag accctcaccg ttggcgggaa gtcctatacc       60

tactaccgcc tggacgctct tcaggagcaa ggcgtagccg acatctcccg cctccccatt      120

tccatcaaaa ttctgcttga atccgtgctt cgccagtacg atggccgcgt catcacggag      180

gagcacgtgc gcgaactcgc caactggaac gcggcgaacc cggcgaaatc cgaggtccct      240

tttaagcccg cgcgcatcct gctgcaggat ttcacgggcg tgcctgtcgt ggtggatctg      300

gccgccatgc gcacggcgat gcacaagctc ggcggcaatc cgaagcggat caacccgctc      360

atcccggtcg atctcgtcat cgaccactcg gtgcaggtgg acgcgttcgg ttccaaagag      420

gcgctggagt tcaacatcgc gaaggaattc gagcgcaacg aggagcgcta ccgcttcctc      480

cgctgggcac aaacggcgtt cgacaacttc cgcgcggtgc cacccggaat gggcatcgtc      540

caccaggtca acctggagta cctcgcgcgc gtggtccagg agcggaccgt cgacggcgag      600

caagtcgtct tcccggatag cctcgtcggc accgactcgc acacgaccat gatcaacggc      660

gtcggcgtcc tcggctgggg cgtgggcggc atcgaggccg aggcgtgcat gctcggtcag      720

cccttgtact tcgtgcagcc cgaggtcatc ggcttcaagc tgaccggcaa actgcccgag      780

ggcgcgaccg cgaccgatct cgccctgact gtcgtgaaca tgctgcgcaa gaagggcgtc      840

gtcggcaagt tcgtcgagtt ctacggcgcc ggcctctcca acatcagcgt cgctgaccgc      900

gcgaccatcg ccaacatggc gcccgagtac ggtgcgacga tgggcttctt ccccatcgac      960

caggcgacgc tcgactatct ccgcctgacc ggccgcgacg aatcgctcat ccagctcgtc     1020

gaggcgtacg cgaaggcaca gggtatgttc cgcacggacg acatgccgga tcccgtcttc     1080

accgacacgc tggagctcga tctcggctcc atccagccga cgatggcggg tccgaagcgg     1140

ccgcaggata agatcttcct ctccgatatg aagaacaact tcgaggcggc gctcgagaag     1200

ccggtgtcgg agggcggttt cgggcttgcg gaccagcggg ataagacggc ccttgtccaa     1260

tatccggacg ggcacaagga cgaactccac cacggcgcgg tcgtgatcgc cgccatcacg     1320

agctgcacca acacctccaa cccgtccgtg atgattggcg cggggctgtt ggcgaagaag     1380

gccgtggaga aggggctgaa gacgccgcgc tacgtgaaga cgtcgctcgc gccgggatcg     1440

cgcgtcgtca cggattacct ggagcgctcg ggcctgctcg agccactctc caagctcggc     1500

tttgacgtgg tcggctacgg ctgtaccacg tgcatcggaa acagcggccc gctgccggag     1560

gaagtggcca aggcgattca ggagaacgac ctcctggtct ccgcggtgtt gtcgggcaac     1620

cgcaacttcg aggggcgcat ccactcgctc gttcgcgcca actatctcgc ttcgccgccg     1680

ctcgtcgtgg cgtacgctat cgcgggcacg gtggacatcg atctcgtcaa cgagcccatc     1740

ggcaaggacg agaacggcaa cgacgtgttc ctgagggaca tctggccgtc gaacgaggag     1800

attcaggcgg tcatccggca aatcatcaat ccggagatgt tcaagaagga atacgagagc     1860

gtgttcaacc ggaacgagcg gtggaacaag ctggacgtcc cgaagggcga gctgtacgaa     1920

tgggatccga attcgacgta catccaggag ccgccgttct tcgaggggct gtcggaagag     1980

gttccggaca tccaggagat ccaaggcgcg cgcgtgctcg cgtacctggg cgactcggtg     2040

acgacggacc acatctcgcc cgcgggcagc atcgcgccgt cgagcccggc tggccagtac     2100

ctgcagtcca agggcgtgaa gccgcatgag ttcaactcgt acggttcgcg ccgcggcaac     2160

cacgaggtca tgatgcgcgg cacgttcgcg aacatccgca ttcgcaacaa ggtggcgcct     2220

ggcacggagg gcggttacac gacgtacttc ccgacgggcg aagtgatgcc gatttacgac     2280

gcggcgatga agtacaaggc ggatggcacg ccgctcgtgg tcatcgccgg caaggagtac     2340

ggaacaggct cgtcccgcga ctgggcggcg aagggcacct acttgctcgg cgtgaaggcc     2400

gtgatcgcgg agagcttcga gcgcatccac cggagcaacc tggtcggcat gggcgtgctg     2460

ccgctcgagt tcatcgacgg gcaaaacgcg gagacgcttg gcctgaccgg ccgcgaggtg     2520

tacaccatca aggggctgtc gaacgacctg aagccgcgcc agacggtcac ggtcgaagtc     2580

acgcgcgaag acggatcgtc gttcacgttc caagcgctcg tgcggctcga cagcgacatc     2640

gaggtggatt actaccgcaa cggcggtatc ctgcagacag tgctccgcaa cttcatgcgc     2700

gagcaacacg cgtaa                                                      2715


<210>   955
<211>   893
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   955
Leu Tyr Gln Ala Lys Lys Gln Phe Glu Val Asn Gly Lys Thr Tyr His 
                5                   10                  15      

Tyr Tyr Asp Leu Lys Ala Ile Glu Glu Ala Gly Ile Gly Asn Val Ser 
            20                  25                  30          

Lys Leu Pro Tyr Ser Ile Arg Val Leu Leu Glu Ser Val Leu Arg Gln 
        35                  40                  45              

His Asp Gly Arg Val Ile Lys Gln Glu His Val Asp Asn Leu Ala Lys 
    50                  55                  60                  

Phe Gly Ser Gly Glu Leu Ala Ala Ile Asp Val Pro Phe Lys Pro Ala 
65                  70                  75                  80  

Arg Val Ile Leu Gln Asp Phe Thr Gly Val Pro Ala Val Val Asp Leu 
                85                  90                  95      

Ala Ser Leu Arg Lys Ala Met Ala Asp Phe Gly Gly Asp Pro Lys Glu 
            100                 105                 110         

Ile Asn Pro Ala Ile Pro Val Asp Leu Val Val Asp His Ser Leu Gln 
        115                 120                 125             

Val Asp Lys Phe Gly Ala Ala Asp Ser Leu Met Phe Asn Met Glu Arg 
    130                 135                 140                 

Glu Phe Glu Arg Asn Leu Glu Arg Tyr Lys Phe Leu Asn Trp Ala Gln 
145                 150                 155                 160 

Lys Ser Leu Asp Asn Tyr Arg Ala Val Pro Pro Ala Thr Gly Ile Val 
                165                 170                 175     

His Gln Val Asn Leu Glu Tyr Leu Ala Asn Val Val Gln Glu Glu Glu 
            180                 185                 190         

Gln Asp Gly Glu Leu Val Ala Phe Pro Asp Ser Leu Val Gly Thr Asp 
        195                 200                 205             

Ser His Thr Thr Met Ile Asn Gly Leu Gly Val Leu Gly Trp Gly Val 
    210                 215                 220                 

Gly Gly Ile Glu Ala Glu Ala Gly Met Leu Lys Gln Pro Ser Tyr Phe 
225                 230                 235                 240 

Pro Val Pro Glu Val Val Gly Leu Lys Phe Thr Gly Lys Met Pro Glu 
                245                 250                 255     

Gly Ala Thr Ala Thr Asp Leu Ala Leu Lys Val Thr Gln Ile Leu Arg 
            260                 265                 270         

Gln Ala Asn Val Val Gly Lys Phe Val Glu Phe Phe Gly Pro Gly Leu 
        275                 280                 285             

Ser Asp Met Thr Leu Ala Asp Arg Ala Thr Ile Ser Asn Met Ala Pro 
    290                 295                 300                 

Glu Tyr Gly Ala Thr Cys Gly Phe Phe Pro Val Asp Glu Glu Thr Leu 
305                 310                 315                 320 

Asn Tyr Met Arg Phe Thr Gly Arg Ser Glu Glu Leu Val Lys Leu Val 
                325                 330                 335     

Glu Thr Tyr Thr Lys Ala Asn Asp Met Tyr Tyr Thr Pro Asp Lys Glu 
            340                 345                 350         

Asp Pro Glu Phe Thr Glu Val Ile Glu Leu Asp Leu Gly Thr Ile Glu 
        355                 360                 365             

Pro Asn Leu Ser Gly Pro Lys Arg Pro Gln Asp Leu Ile Pro Leu Ser 
    370                 375                 380                 

Gln Met Lys Lys Glu Trp Arg Lys Ala Leu Thr Ala Pro Val Gly Asn 
385                 390                 395                 400 

Gln Gly Phe Gly Leu Glu Ala Ala Glu Ala Asp Arg Ser Val Asp Val 
                405                 410                 415     

Lys His Pro Asp Gly Arg Thr Ser Gln Leu Lys Thr Gly Ala Val Thr 
            420                 425                 430         

Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro His Val Met 
        435                 440                 445             

Ile Gly Ser Gly Leu Leu Ala Lys Asn Ala Val Asp Lys Gly Leu Glu 
    450                 455                 460                 

Val Pro Ala Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser Lys Val Val 
465                 470                 475                 480 

Thr Gly Tyr Leu Glu Asp Ala Gly Leu Met Pro Tyr Leu Asp Lys Leu 
                485                 490                 495     

Gly Phe Asn Leu Val Gly Tyr Gly Cys Thr Thr Cys Ile Gly Asn Ser 
            500                 505                 510         

Gly Pro Leu Pro Asp Glu Val Glu Gln Ala Ile Ser Glu Asn Asp Leu 
        515                 520                 525             

Thr Val Ser Ser Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg Ile 
    530                 535                 540                 

His Pro Leu Val Lys Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Val 
545                 550                 555                 560 

Ala Tyr Ala Leu Ala Gly Thr Val Asp Ile Asp Phe Glu Thr Glu Pro 
                565                 570                 575     

Leu Gly Gln Asp Lys Glu Gly Asn Asp Val Phe Phe Arg Asp Ile Trp 
            580                 585                 590         

Pro Ser Asn Glu Glu Ile His Lys Ser Met Gln Glu Ala Val Asp Pro 
        595                 600                 605             

Lys Leu Phe Lys Arg Glu Tyr Lys Arg Val Phe Asp Asp Asn Glu Arg 
    610                 615                 620                 

Trp Asn Ala Leu Glu Thr Pro Asp Gly Asp Leu Tyr Glu Phe Asp Glu 
625                 630                 635                 640 

Glu Ser Thr Tyr Ile Gln Asn Pro Pro Phe Phe Glu Asn Leu Ser Pro 
                645                 650                 655     

Asp Pro Lys Asp Val Glu Lys Leu Ser Gly Leu Arg Ala Val Gly Lys 
            660                 665                 670         

Phe Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Ala Ile 
        675                 680                 685             

Ala Lys Asn Ser Pro Ala Gly Arg Tyr Leu Met Glu Lys Gly Leu Glu 
    690                 695                 700                 

Pro Lys Asp Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn His Glu Val 
705                 710                 715                 720 

Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Lys Asn Gln Leu Ala 
                725                 730                 735     

Pro Gly Thr Glu Gly Gly Tyr Thr Thr His Trp Pro Thr Gly Asp Val 
            740                 745                 750         

Met Ala Ile Tyr Asp Ala Cys Met Gln Tyr Lys Glu Glu Gly Thr Gly 
        755                 760                 765             

Leu Leu Val Met Ala Gly Lys Asp Tyr Gly Met Gly Ser Ser Arg Asp 
    770                 775                 780                 

Trp Ala Ala Lys Gly Thr Asn Leu Leu Gly Ile Lys Thr Val Ile Ala 
785                 790                 795                 800 

Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Leu Met Gly Val 
                805                 810                 815     

Leu Pro Leu Gln Phe Lys Ser Gly Glu Asn Ala Asp Thr Leu Gly Leu 
            820                 825                 830         

Thr Gly Glu Glu His Phe Asp Val His Val Asp Asn Asp Val Gln Pro 
        835                 840                 845             

Arg Gln Glu Ile Lys Val Thr Ala Thr Asp Ser Asp Gly Lys Gly Thr 
    850                 855                 860                 

Glu Phe His Val Ile Ala Arg Phe Asp Ser Glu Val Glu Ile Asp Tyr 
865                 870                 875                 880 

Tyr Arg His Gly Gly Ile Leu Gln Met Val Leu Arg Asn 
                885                 890             

<210>   956
<211>   895
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   956
Phe Gly Ala Lys Ala Thr Leu Thr Val Gly Asp Arg Ser Leu Val Tyr 
                5                   10                  15      

Tyr Arg Leu Asn Lys Leu Glu Glu Asp Gly Ile Ala Ala Val Ser Lys 
            20                  25                  30          

Leu Pro Phe Ser Ile Lys Val Leu Leu Glu Ala Met Leu Arg Asn Asn 
        35                  40                  45              

Asp Gly Phe Ala Val Thr Lys Gln Asp Val Glu Asn Met Ala Arg Trp 
    50                  55                  60                  

Asn Ala Ala Asn Pro Glu Lys Ile Glu Val Pro Phe Lys Pro Ala Arg 
65                  70                  75                  80  

Val Ile Leu Gln Asp Phe Thr Gly Val Pro Ala Val Val Asp Leu Ala 
                85                  90                  95      

Ala Met Arg Ala Ala Met Ala Gln Gln Gly Gly Asp Pro Gln Arg Ile 
            100                 105                 110         

Asn Pro Leu Val Pro Val Asp Leu Val Ile Asp His Ser Val Gln Ile 
        115                 120                 125             

Asp Gln Phe Gly Ser Lys Met Ala Leu Phe Phe Asn Ala Glu Arg Glu 
    130                 135                 140                 

Phe Glu Arg Asn Ala Glu Arg Tyr Glu Phe Leu Lys Trp Gly Gln Gln 
145                 150                 155                 160 

Ala Phe Asp Asn Phe Ser Val Val Pro Pro Glu Thr Gly Ile Val His 
                165                 170                 175     

Gln Val Asn Leu Glu Tyr Leu Ala Lys Val Val Gln Val Phe Thr Glu 
            180                 185                 190         

Glu Gly Glu Leu Val Ala Leu Pro Asp Ser Leu Val Gly Thr Asp Ser 
        195                 200                 205             

His Thr Thr Met Ile Asn Gly Leu Gly Val Val Gly Trp Gly Val Gly 
    210                 215                 220                 

Gly Ile Glu Ala Glu Ala Val Met Leu Gly Gln Pro Ile Tyr Met Leu 
225                 230                 235                 240 

Leu Pro Glu Val Ile Gly Phe Lys Val Thr Gly Gln Leu Pro Glu Gly 
                245                 250                 255     

Ala Thr Ala Thr Asp Leu Ala Leu Thr Val Thr Glu Leu Leu Arg Lys 
            260                 265                 270         

Lys Gly Val Val Gly Lys Phe Val Glu Phe Tyr Gly Pro Gly Val Ala 
        275                 280                 285             

Asn Met Ala Leu Ser Asp Arg Ala Thr Ile Ala Asn Met Ala Pro Glu 
    290                 295                 300                 

Tyr Gly Ala Thr Met Gly Phe Phe Pro Val Asp Gln Glu Thr Ile His 
305                 310                 315                 320 

Phe Leu Arg Ser Thr Gly Arg Ser Asp Glu Leu Ala Asp Leu Val Glu 
                325                 330                 335     

Ala Tyr Ser Lys Ala Gln Gly Leu Phe Leu Asp Ala Asn Ser Pro Glu 
            340                 345                 350         

Ala Glu Tyr Thr Asp Thr Val His Leu Asp Leu Ser Thr Ile Val Pro 
        355                 360                 365             

Ser Val Ala Gly Pro Lys Arg Pro Gln Asp Arg Val Glu Leu Gln Asn 
    370                 375                 380                 

Thr Lys Ala Ser Phe Gln Lys Ser Leu Thr Ala Pro Ile Ala Glu Arg 
385                 390                 395                 400 

Gly Phe Ala Leu Ser Thr Glu Lys Ala Glu Asn Thr Ala Thr Val Gln 
                405                 410                 415     

Asn Asn Gly His Ser Ala Thr Ile Gly His Gly Ala Val Val Ile Ala 
            420                 425                 430         

Ser Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro Ser Val Met Leu Gly 
        435                 440                 445             

Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Lys Gly Leu Thr Val Ala 
    450                 455                 460                 

Pro Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser Arg Val Val Ser Ser 
465                 470                 475                 480 

Tyr Leu Glu Gln Ala Glu Leu Ile Glu Pro Leu Glu Ala Leu Gly Phe 
                485                 490                 495     

His Val Val Gly Tyr Gly Cys Thr Thr Cys Ile Gly Asn Ser Gly Pro 
            500                 505                 510         

Leu Pro Glu Pro Val Ala Ala Ala Val Gln Glu Gly Glu Leu Val Ala 
        515                 520                 525             

Ala Ala Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg Ile Asn Pro 
    530                 535                 540                 

Leu Val Lys Ala Ala Tyr Leu Ala Ser Pro Pro Leu Val Val Ala Tyr 
545                 550                 555                 560 

Ala Leu Ala Gly Thr Ile Asn Leu Asp Leu Ala Thr Glu Pro Leu Gly 
                565                 570                 575     

Asn Asp Lys Glu Gly Asn Pro Val Tyr Leu Arg Asp Ile Trp Pro Ser 
            580                 585                 590         

Gln Ser Glu Ile Gln Glu Thr Val Arg Lys Ala Ile Lys Pro Glu Met 
        595                 600                 605             

Phe Thr Gln Gln Tyr Gly Asn Val Phe Ala Gly Ser Asp Ala Trp Lys 
    610                 615                 620                 

Arg Val Gln Ala Pro Thr Gly Asn Ile Tyr Ala Trp Asn Asn Asp Ser 
625                 630                 635                 640 

Thr Tyr Ile Gln His Pro Pro Phe Phe Gln Asp Leu Gln Pro Glu Pro 
                645                 650                 655     

Ala Pro Ile Gly Asp Ile Thr Gly Ala Arg Val Leu Ala Leu Leu Gly 
            660                 665                 670         

Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Ser Ile Ala Lys 
        675                 680                 685             

Asn Ser Pro Ala Ala Lys Tyr Leu Ile Asp Asn Gly Val Asp Pro Gln 
    690                 695                 700                 

Asp Phe Asn Ser Tyr Gly Ala Arg Arg Gly Asn His Glu Val Met Met 
705                 710                 715                 720 

Arg Gly Thr Phe Ala Asn Ile Arg Leu Lys Asn Leu Leu Leu Asn Gly 
                725                 730                 735     

Val Glu Gly Gly Tyr Thr Leu Tyr Phe Pro Thr Gly Glu Gln Gln Ser 
            740                 745                 750         

Ile Tyr Asp Ala Ser Met Ala Tyr Gln Ala Ser Gly Thr Pro Leu Val 
        755                 760                 765             

Ile Leu Ala Gly Lys Glu Tyr Gly Thr Gly Ser Ser Arg Asp Trp Ala 
    770                 775                 780                 

Ala Lys Gly Thr Tyr Leu Leu Gly Val Lys Val Val Ile Ala Glu Ser 
785                 790                 795                 800 

Tyr Glu Arg Ile His Arg Ser Asn Leu Val Gly Met Gly Val Leu Pro 
                805                 810                 815     

Leu Gln Tyr Arg Ala Gly Glu Ser Ala Ala Ser Leu Gly Leu Lys Gly 
            820                 825                 830         

Asp Glu Ser Phe Ser Val Glu Gly Ile Asn Asp Asp Leu Gln Ala Arg 
        835                 840                 845             

Ser Glu Leu Thr Val Arg Ala Val Arg Pro Asp Gly Ser Glu Leu Ser 
    850                 855                 860                 

Phe Gln Ala Val Val Arg Ile Asp Thr Pro Val Glu Val Glu Tyr Tyr 
865                 870                 875                 880 

Lys Asn Gly Gly Ile Leu His Thr Val Leu Arg Gln Leu Ala Lys 
                885                 890                 895 

<210>   957
<211>   894
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   957
Asp Val Phe Asn Ala Arg Ser Ser Phe Glu Val Asn Gly Lys Lys Tyr 
                5                   10                  15      

Asn Tyr Tyr Arg Leu Gln Ala Leu Glu Glu Ala Gly Ile Gly Arg Val 
            20                  25                  30          

Ser Arg Leu Pro Tyr Ser Ile Lys Val Leu Leu Glu Ser Val Leu Arg 
        35                  40                  45              

Gln Val Asp Gly Arg Val Ile Thr Lys Glu His Val Glu Asn Leu Ala 
    50                  55                  60                  

Lys Trp Gly Thr Pro Glu Met Lys Asp Ile Asp Val Pro Phe Lys Pro 
65                  70                  75                  80  

Ser Arg Val Ile Leu Gln Asp Phe Thr Gly Val Pro Ala Val Val Asp 
                85                  90                  95      

Leu Ala Ser Met Arg Lys Ala Met Ala Asp Leu Gly Gly Asp Pro Tyr 
            100                 105                 110         

Glu Ile Asn Pro Glu Ile Pro Val Asp Leu Val Ile Asp His Ser Val 
        115                 120                 125             

Gln Val Asp Arg Tyr Gly Ser Asp Asp Ala Leu Glu Tyr Asn Met Asp 
    130                 135                 140                 

Leu Glu Phe Gln Arg Asn Ala Glu Arg Tyr Lys Phe Leu Lys Trp Ala 
145                 150                 155                 160 

Gln Lys Ala Phe Asp Asn Tyr Arg Ala Val Pro Pro Ala Thr Gly Ile 
                165                 170                 175     

Val His Gln Val Asn Leu Glu Tyr Leu Ala Ser Val Val His Ala Val 
            180                 185                 190         

Glu Gly Glu Asn Gly Glu Tyr Glu Ala Phe Pro Asp Thr Leu Val Gly 
        195                 200                 205             

Thr Asp Ser His Thr Thr Met Ile Asn Gly Ile Gly Val Leu Gly Trp 
    210                 215                 220                 

Gly Val Gly Gly Ile Glu Ala Glu Ala Gly Met Leu Gly Gln Pro Ser 
225                 230                 235                 240 

Tyr Phe Pro Val Pro Glu Val Val Gly Val Arg Leu Thr Gly Lys Leu 
                245                 250                 255     

Pro Asp Gly Ser Thr Ala Thr Asp Leu Ala Leu Lys Val Thr Gln Val 
            260                 265                 270         

Leu Arg Lys Lys Gly Val Val Gly Lys Phe Val Glu Phe Phe Gly Pro 
        275                 280                 285             

Gly Val Ala Thr Leu Pro Leu Ala Asp Arg Ala Thr Ile Ala Asn Met 
    290                 295                 300                 

Ala Pro Glu Tyr Gly Ala Thr Cys Gly Phe Phe Pro Val Asp Ala Glu 
305                 310                 315                 320 

Ala Leu Asp Tyr Leu Arg Leu Thr Gly Arg Asp Glu His His Ile Gln 
                325                 330                 335     

Val Val Glu Ala Tyr Cys Lys Ala Asn Gly Leu Phe Tyr Thr Pro Asp 
            340                 345                 350         

Ala Pro Glu Pro Thr Phe Thr Asp Val Val Glu Ile Asn Leu Ser Glu 
        355                 360                 365             

Ile Glu Thr Asn Leu Ser Gly Pro Lys Arg Pro Gln Asp Leu Ile Pro 
    370                 375                 380                 

Leu Ser Lys Met Lys Gln Ser Phe Arg Glu Ala Val Lys Ala Pro Gln 
385                 390                 395                 400 

Gly Asn Gln Gly Phe Gly Leu Thr Glu Ala Asp Leu Glu Arg Glu Ile 
                405                 410                 415     

Thr Val Thr Leu Asn Gly Glu Gln Val Ser Met Lys Thr Gly Ala Val 
            420                 425                 430         

Val Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro Tyr Val 
        435                 440                 445             

Leu Val Ala Ala Gly Leu Val Ala Lys Lys Ala Val Glu Lys Gly Leu 
    450                 455                 460                 

Gln Val Pro Lys Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser Lys Val 
465                 470                 475                 480 

Val Thr Gly Tyr Leu Arg Asp Ser Gly Leu Leu Pro Tyr Leu Gln Gln 
                485                 490                 495     

Leu Gly Phe Asn Val Val Gly Tyr Gly Cys Thr Thr Cys Ile Gly Asn 
            500                 505                 510         

Ser Gly Pro Leu Ala Pro Glu Leu Glu Lys Ala Leu Ala Glu Ser Asp 
        515                 520                 525             

Leu Leu Val Thr Ser Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg 
    530                 535                 540                 

Ile His Pro Leu Val Lys Gly Asn Tyr Leu Ala Ser Pro Pro Leu Val 
545                 550                 555                 560 

Val Ala Tyr Ala Leu Ala Gly Thr Val Asp Ile Asp Leu Leu Asn Glu 
                565                 570                 575     

Pro Ile Gly Lys Asp Lys Asp Gly Asn Asp Val Tyr Phe Arg Asp Ile 
            580                 585                 590         

Trp Pro Ser Met Glu Glu Val Lys Glu Val Val Lys Arg Ala Val Asp 
        595                 600                 605             

Pro Glu Leu Phe Arg Lys Glu Tyr Glu Arg Val Phe Asp Gly Asn Pro 
    610                 615                 620                 

Arg Trp Asn Ala Ile Glu Thr Thr Asp Glu Pro Leu Tyr Gln Trp Asp 
625                 630                 635                 640 

Glu Gln Ser Thr Tyr Ile Gln Asn Pro Pro Phe Phe Glu Gly Leu Ser 
                645                 650                 655     

Pro Asp Val Arg Lys Val Glu Pro Leu Thr Gly Leu Arg Val Val Gly 
            660                 665                 670         

Lys Phe Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Ser 
        675                 680                 685             

Ile Gly Lys Ser Thr Pro Ala Gly Gln Tyr Leu Ile Ser Lys Gly Val 
    690                 695                 700                 

Glu Pro Lys Asp Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn His Glu 
705                 710                 715                 720 

Val Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Arg Asn Gln Ile 
                725                 730                 735     

Ala Pro Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Trp Pro Thr Gly Glu 
            740                 745                 750         

Val Met Ser Ile Tyr Asp Ala Cys Met Lys Tyr Lys Gln Asp Gly Thr 
        755                 760                 765             

Gly Leu Val Val Val Ala Gly Lys Asp Tyr Gly Met Gly Ser Ser Arg 
    770                 775                 780                 

Asp Trp Ala Ala Lys Gly Thr Phe Leu Leu Gly Ile Lys Thr Val Ile 
785                 790                 795                 800 

Ala Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Leu Met Gly 
                805                 810                 815     

Val Leu Pro Leu Gln Phe Lys Glu Gly Glu Asn Ala Glu Thr Leu Gly 
            820                 825                 830         

Leu Thr Gly Lys Glu Val Phe Glu Val Gln Ile Asp Glu Ser Val Lys 
        835                 840                 845             

Pro Arg Asp Leu Val Lys Val Thr Ala Thr Asn Pro Asp Thr Gly Glu 
    850                 855                 860                 

Lys Lys Glu Phe Glu Val Ile Val Arg Phe Asp Ser Glu Val Glu Ile 
865                 870                 875                 880 

Asp Tyr Tyr Arg His Gly Gly Ile Leu Gln Met Val Leu Arg 
                885                 890                 

<210>   958
<211>   894
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   958
Asp Val Phe Asn Thr Arg Ser Ser Phe Glu Val Asn Gly Lys Lys Tyr 
                5                   10                  15      

Asn Tyr Tyr Arg Leu Gln Ala Leu Glu Glu Ala Gly Ile Gly Gln Val 
            20                  25                  30          

Ser Arg Leu Pro Tyr Ser Ile Lys Val Leu Leu Glu Ser Val Leu Arg 
        35                  40                  45              

Gln Val Asp Gly Arg Val Ile Thr Lys Glu His Val Glu Asn Leu Ala 
    50                  55                  60                  

Lys Trp Gly Thr Pro Glu Met Lys Asp Ile Asp Val Pro Phe Lys Pro 
65                  70                  75                  80  

Ser Arg Val Ile Leu Gln Asp Phe Thr Gly Val Pro Val Val Val Asp 
                85                  90                  95      

Leu Ala Ser Met Arg Lys Ala Met Ala Asp Leu Gly Gly Asp Pro Tyr 
            100                 105                 110         

Glu Ile Asn Pro Glu Ile Pro Val Asp Leu Val Ile Asp His Ser Val 
        115                 120                 125             

Gln Val Asp Arg Tyr Gly Ser Asp Asp Ala Leu Glu Tyr Asn Met Asp 
    130                 135                 140                 

Leu Glu Phe Lys Arg Asn Ala Glu Arg Tyr Lys Phe Leu Lys Trp Ala 
145                 150                 155                 160 

Gln Lys Ala Phe Asp Asn Tyr Arg Ala Val Pro Pro Ala Thr Gly Ile 
                165                 170                 175     

Val His Gln Val Asn Leu Glu Tyr Leu Ala Ser Val Val His Ala Val 
            180                 185                 190         

Glu Gly Glu Asn Gly Glu Tyr Glu Ala Phe Pro Asp Thr Leu Val Gly 
        195                 200                 205             

Thr Asp Ser His Thr Thr Met Ile Asn Gly Leu Gly Val Leu Gly Trp 
    210                 215                 220                 

Gly Val Gly Gly Ile Glu Ala Glu Ala Gly Met Leu Gly Gln Pro Ser 
225                 230                 235                 240 

Tyr Phe Pro Val Pro Glu Val Ile Gly Val Arg Leu Thr Gly Lys Leu 
                245                 250                 255     

Pro Asp Gly Ala Thr Ala Thr Asp Leu Ala Leu Lys Val Thr Gln Val 
            260                 265                 270         

Leu Arg Lys Lys Gly Val Val Gly Lys Phe Val Glu Phe Phe Gly Pro 
        275                 280                 285             

Gly Val Ala Thr Leu Pro Leu Ala Asp Arg Ala Thr Ile Ala Asn Met 
    290                 295                 300                 

Ala Pro Glu Tyr Gly Ala Thr Cys Gly Phe Phe Pro Val Asp Ala Glu 
305                 310                 315                 320 

Ala Leu Asp Tyr Leu Arg Leu Thr Gly Arg Asp Glu His His Val Gln 
                325                 330                 335     

Val Val Glu Ala Tyr Cys Lys Ala Asn Gly Leu Phe Tyr Thr Pro Asp 
            340                 345                 350         

Ala Pro Glu Pro Val Phe Thr Asp Val Val Glu Ile Asn Leu Ser Glu 
        355                 360                 365             

Ile Glu Thr Asn Leu Ser Gly Pro Lys Arg Pro Gln Asp Leu Ile Pro 
    370                 375                 380                 

Leu Ser Lys Met Lys Gln Ser Phe Arg Asp Ala Val Lys Ala Pro Gln 
385                 390                 395                 400 

Gly Asn Gln Gly Phe Gly Leu Thr Glu Ala Asp Leu Glu Arg Glu Ile 
                405                 410                 415     

Thr Val Glu Leu Asn Gly Glu Gln Val Lys Leu Lys Thr Gly Ala Val 
            420                 425                 430         

Val Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro Tyr Val 
        435                 440                 445             

Leu Val Ala Ala Gly Leu Val Ala Lys Lys Ala Val Glu Lys Gly Leu 
    450                 455                 460                 

Gln Val Pro Lys Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser Lys Val 
465                 470                 475                 480 

Val Thr Gly Tyr Leu Arg Asp Ser Gly Leu Leu Pro Tyr Leu Glu Gln 
                485                 490                 495     

Leu Gly Phe Asn Ile Val Gly Tyr Gly Cys Thr Thr Cys Ile Gly Asn 
            500                 505                 510         

Ser Gly Pro Leu Ala Pro Glu Leu Glu Lys Ala Leu Ala Glu Ser Asp 
        515                 520                 525             

Leu Leu Val Thr Ser Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg 
    530                 535                 540                 

Ile His Pro Leu Val Lys Gly Asn Tyr Leu Ala Ser Pro Pro Leu Val 
545                 550                 555                 560 

Val Ala Tyr Ala Leu Ala Gly Thr Val Asp Ile Asp Leu Leu Ser Glu 
                565                 570                 575     

Pro Ile Gly Lys Gly Lys Asp Gly Ser Asp Val Tyr Phe Arg Asp Ile 
            580                 585                 590         

Trp Pro Ser Met Glu Glu Val Lys Asp Val Val Lys Arg Ala Val Asp 
        595                 600                 605             

Pro Glu Leu Phe Arg Lys Glu Tyr Glu Arg Val Phe Asp Gly Asn Pro 
    610                 615                 620                 

Arg Trp Asn Ala Ile Glu Thr Thr Asp Glu Pro Leu Tyr Gln Trp Asp 
625                 630                 635                 640 

Glu Asn Ser Thr Tyr Ile Gln Asn Pro Pro Phe Phe Glu Gly Leu Ser 
                645                 650                 655     

Pro Glu Val Arg Lys Val Glu Pro Leu Thr Gly Leu Arg Val Val Gly 
            660                 665                 670         

Lys Phe Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Ser 
        675                 680                 685             

Ile Gly Lys Asn Thr Pro Ala Gly Gln Tyr Leu Ile Ser Lys Gly Val 
    690                 695                 700                 

Asp Pro Lys Asp Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn His Glu 
705                 710                 715                 720 

Val Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Arg Asn Gln Ile 
                725                 730                 735     

Ala Pro Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Trp Pro Thr Gly Glu 
            740                 745                 750         

Val Met Ser Met Tyr Asp Ala Cys Met Lys Tyr Lys Gln Asp Gly Thr 
        755                 760                 765             

Gly Leu Val Val Ile Ala Gly Lys Asp Tyr Gly Met Gly Ser Ser Arg 
    770                 775                 780                 

Asp Trp Ala Ala Lys Gly Thr Phe Leu Leu Gly Ile Lys Thr Val Ile 
785                 790                 795                 800 

Ala Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Leu Met Gly 
                805                 810                 815     

Val Leu Pro Leu Gln Phe Lys Glu Gly Glu Asn Ala Glu Thr Leu Gly 
            820                 825                 830         

Leu Thr Gly Lys Glu Val Phe Asp Ile His Ile Asp Glu Asn Val Lys 
        835                 840                 845             

Pro Arg Asp Leu Val Lys Val Thr Ala Thr Asn Pro Asp Thr Gly Glu 
    850                 855                 860                 

Lys Lys Glu Phe Glu Val Ile Val Arg Phe Asp Ser Glu Val Glu Ile 
865                 870                 875                 880 

Asp Tyr Tyr Arg His Gly Gly Ile Leu Gln Met Val Leu Arg 
                885                 890                 

<210>   959
<211>   896
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   959
Phe Gln Ser Arg Lys Thr Phe Thr Val Gln Gly Lys Thr Tyr Ser Tyr 
                5                   10                  15      

Tyr Ser Leu Lys Ala Leu Glu Asp Gln Gly Ile Gly Asn Val Ser Lys 
            20                  25                  30          

Leu Pro Tyr Ser Ile Lys Val Leu Leu Glu Ser Val Leu Arg Gln Val 
        35                  40                  45              

Asp Gly Arg Val Ile Thr Glu Glu His Val Glu Asn Leu Ala Lys Trp 
    50                  55                  60                  

Gly Thr Ala Glu Leu Lys Asp Ile Asp Val Pro Phe Lys Pro Ser Arg 
65                  70                  75                  80  

Val Ile Leu Gln Asp Phe Thr Gly Val Pro Ala Val Val Asp Leu Ala 
                85                  90                  95      

Ser Leu Arg Lys Ala Met Ala Ser Val Gly Gly Asp Pro Asp Lys Ile 
            100                 105                 110         

Asn Pro Glu Ile Pro Val Asp Leu Val Ile Asp His Ser Val Gln Val 
        115                 120                 125             

Asp Lys Ala Gly Thr Glu Asp Ala Leu Thr Val Asn Met Asp Leu Glu 
    130                 135                 140                 

Phe Gln Arg Asn Ala Glu Arg Tyr Lys Phe Leu Ser Trp Ala Lys Lys 
145                 150                 155                 160 

Ala Phe Asn Asn Tyr Gln Ala Val Pro Pro Ala Thr Gly Ile Val His 
                165                 170                 175     

Gln Val Asn Leu Glu Tyr Leu Ala Asn Val Val His Ala Val Glu Glu 
            180                 185                 190         

Asp Gly Glu Ile Val Thr Tyr Pro Asp Thr Leu Val Gly Thr Asp Ser 
        195                 200                 205             

His Thr Thr Met Ile Asn Gly Ile Gly Val Leu Gly Trp Gly Val Gly 
    210                 215                 220                 

Gly Ile Glu Ala Glu Ala Gly Met Leu Gly Gln Pro Ser Tyr Phe Pro 
225                 230                 235                 240 

Val Pro Glu Val Ile Gly Ala Lys Leu Val Gly Lys Leu Pro Asn Gly 
                245                 250                 255     

Thr Thr Ala Thr Asp Leu Ala Leu Lys Val Thr Gln Val Leu Arg Glu 
            260                 265                 270         

Lys Gly Val Val Gly Lys Phe Val Glu Phe Phe Gly Pro Gly Val Ala 
        275                 280                 285             

Glu Leu Pro Leu Ala Asp Arg Ala Thr Ile Ala Asn Met Ala Pro Glu 
    290                 295                 300                 

Tyr Gly Ala Thr Cys Gly Phe Phe Pro Val Asp Glu Glu Ala Leu Glu 
305                 310                 315                 320 

Tyr Met Arg Leu Thr Gly Arg Asp Glu Glu His Ile Asn Val Val Lys 
                325                 330                 335     

Glu Tyr Cys Arg Gln Asn Gly Leu Phe Tyr Thr Pro Asp Gln Glu Asp 
            340                 345                 350         

Pro Val Phe Thr Asp Ile Val Glu Ile Asp Leu Ser Lys Val Glu Ala 
        355                 360                 365             

Asn Leu Ser Gly Pro Lys Arg Pro Gln Asp Leu Ile Pro Leu Thr Asp 
    370                 375                 380                 

Met Lys Glu Thr Phe His Lys His Leu Ala Ser Pro Ala Gly Asn Gln 
385                 390                 395                 400 

Gly Phe Gly Leu Asn Ala Ser Glu Ala Asp Lys Glu Ile Lys Phe Lys 
                405                 410                 415     

Leu Glu Asn Gly Glu Glu Ala Val Met Lys Thr Gly Ala Ile Ala Ile 
            420                 425                 430         

Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro Tyr Val Leu Ile 
        435                 440                 445             

Gly Ala Gly Leu Val Ala Lys Lys Ala Val Glu Leu Gly Leu Lys Val 
    450                 455                 460                 

Pro Asn Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser Lys Val Val Thr 
465                 470                 475                 480 

Gly Tyr Leu Val Asn Ser Gly Leu Leu Pro Tyr Met Arg Glu Leu Gly 
                485                 490                 495     

Phe Asn Ile Val Gly Tyr Gly Cys Thr Thr Cys Ile Gly Asn Ser Gly 
            500                 505                 510         

Pro Leu Ala Pro Glu Ile Glu Lys Ala Val Ala Glu Asn Asp Leu Leu 
        515                 520                 525             

Ile Thr Ser Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg Ile His 
    530                 535                 540                 

Pro Leu Val Lys Gly Asn Tyr Leu Ala Ser Pro Pro Leu Val Val Ala 
545                 550                 555                 560 

Tyr Ala Leu Ala Gly Thr Val Asp Ile Asp Leu Lys Asn Glu Pro Ile 
                565                 570                 575     

Gly Val Gly Lys Asp Gly Gln Asn Val Tyr Phe Asn Asp Ile Trp Pro 
            580                 585                 590         

Thr Met Asp Glu Ile Asn Ser Val Val Lys Gln Thr Val Thr Pro Glu 
        595                 600                 605             

Leu Phe Arg Lys Glu Tyr Glu Arg Val Phe Asp Asp Asn Glu Arg Trp 
    610                 615                 620                 

Asn Ala Ile Glu Thr Thr Asp Glu Ala Leu Tyr Lys Trp Asp Glu Glu 
625                 630                 635                 640 

Ser Thr Tyr Ile Gln Asn Pro Pro Phe Phe Glu Asn Met Ser Val Glu 
                645                 650                 655     

Pro Gly Thr Val Glu Pro Leu Lys Gly Leu Arg Ile Val Gly Lys Phe 
            660                 665                 670         

Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Ala Ile Gly 
        675                 680                 685             

Lys Asp Thr Pro Ala Gly Lys Tyr Leu Gln Glu Lys Gly Val Ser Pro 
    690                 695                 700                 

Arg Asp Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn His Glu Val Met 
705                 710                 715                 720 

Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Lys Asn Gln Ile Ala Pro 
                725                 730                 735     

Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Trp Pro Thr Gly Glu Val Met 
            740                 745                 750         

Ser Ile Tyr Asp Ala Cys Met Lys Tyr Lys Glu Asp Gly Thr Gly Leu 
        755                 760                 765             

Val Val Ile Ala Gly Lys Asp Tyr Gly Met Gly Ser Ser Arg Asp Trp 
    770                 775                 780                 

Ala Ala Lys Gly Thr Asn Leu Leu Gly Ile Lys Thr Val Ile Ala Glu 
785                 790                 795                 800 

Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Leu Met Gly Val Leu 
                805                 810                 815     

Pro Leu Gln Phe Lys Glu Gly Glu Asn Ala Glu Thr Leu Gly Leu Thr 
            820                 825                 830         

Gly Lys Glu Thr Ile Glu Val Asp Val Ser Glu Ser Val Arg Pro Arg 
        835                 840                 845             

Asp Leu Val Gln Val Lys Ala Ile Ala Glu Asp Gly Thr Val Lys Ser 
    850                 855                 860                 

Phe Glu Ala Val Val Arg Phe Asp Ser Glu Val Glu Ile Asp Tyr Tyr 
865                 870                 875                 880 

Arg His Gly Gly Ile Leu Gln Met Val Leu Arg Asn Lys Met Lys Gln 
                885                 890                 895     

<210>   960
<211>   904
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 953

<400>   960
Met Gly Ala Asn Leu Phe Gln Ala Lys Gln Thr Leu Thr Val Gly Gly 
                5                   10                  15      

Lys Ser Tyr Thr Tyr Tyr Arg Leu Asp Ala Leu Gln Glu Gln Gly Val 
            20                  25                  30          

Ala Asp Ile Ser Arg Leu Pro Ile Ser Ile Lys Ile Leu Leu Glu Ser 
        35                  40                  45              

Val Leu Arg Gln Tyr Asp Gly Arg Val Ile Thr Glu Glu His Val Arg 
    50                  55                  60                  

Glu Leu Ala Asn Trp Asn Ala Ala Asn Pro Ala Lys Ser Glu Val Pro 
65                  70                  75                  80  

Phe Lys Pro Ala Arg Ile Leu Leu Gln Asp Phe Thr Gly Val Pro Val 
                85                  90                  95      

Val Val Asp Leu Ala Ala Met Arg Thr Ala Met His Lys Leu Gly Gly 
            100                 105                 110         

Asn Pro Lys Arg Ile Asn Pro Leu Ile Pro Val Asp Leu Val Ile Asp 
        115                 120                 125             

His Ser Val Gln Val Asp Ala Phe Gly Ser Lys Glu Ala Leu Glu Phe 
    130                 135                 140                 

Asn Ile Ala Lys Glu Phe Glu Arg Asn Glu Glu Arg Tyr Arg Phe Leu 
145                 150                 155                 160 

Arg Trp Ala Gln Thr Ala Phe Asp Asn Phe Arg Ala Val Pro Pro Gly 
                165                 170                 175     

Met Gly Ile Val His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val 
            180                 185                 190         

Gln Glu Arg Thr Val Asp Gly Glu Gln Val Val Phe Pro Asp Ser Leu 
        195                 200                 205             

Val Gly Thr Asp Ser His Thr Thr Met Ile Asn Gly Val Gly Val Leu 
    210                 215                 220                 

Gly Trp Gly Val Gly Gly Ile Glu Ala Glu Ala Cys Met Leu Gly Gln 
225                 230                 235                 240 

Pro Leu Tyr Phe Val Gln Pro Glu Val Ile Gly Phe Lys Leu Thr Gly 
                245                 250                 255     

Lys Leu Pro Glu Gly Ala Thr Ala Thr Asp Leu Ala Leu Thr Val Val 
            260                 265                 270         

Asn Met Leu Arg Lys Lys Gly Val Val Gly Lys Phe Val Glu Phe Tyr 
        275                 280                 285             

Gly Ala Gly Leu Ser Asn Ile Ser Val Ala Asp Arg Ala Thr Ile Ala 
    290                 295                 300                 

Asn Met Ala Pro Glu Tyr Gly Ala Thr Met Gly Phe Phe Pro Ile Asp 
305                 310                 315                 320 

Gln Ala Thr Leu Asp Tyr Leu Arg Leu Thr Gly Arg Asp Glu Ser Leu 
                325                 330                 335     

Ile Gln Leu Val Glu Ala Tyr Ala Lys Ala Gln Gly Met Phe Arg Thr 
            340                 345                 350         

Asp Asp Met Pro Asp Pro Val Phe Thr Asp Thr Leu Glu Leu Asp Leu 
        355                 360                 365             

Gly Ser Ile Gln Pro Thr Met Ala Gly Pro Lys Arg Pro Gln Asp Lys 
    370                 375                 380                 

Ile Phe Leu Ser Asp Met Lys Asn Asn Phe Glu Ala Ala Leu Glu Lys 
385                 390                 395                 400 

Pro Val Ser Glu Gly Gly Phe Gly Leu Ala Asp Gln Arg Asp Lys Thr 
                405                 410                 415     

Ala Leu Val Gln Tyr Pro Asp Gly His Lys Asp Glu Leu His His Gly 
            420                 425                 430         

Ala Val Val Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro 
        435                 440                 445             

Ser Val Met Ile Gly Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Lys 
    450                 455                 460                 

Gly Leu Lys Thr Pro Arg Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser 
465                 470                 475                 480 

Arg Val Val Thr Asp Tyr Leu Glu Arg Ser Gly Leu Leu Glu Pro Leu 
                485                 490                 495     

Ser Lys Leu Gly Phe Asp Val Val Gly Tyr Gly Cys Thr Thr Cys Ile 
            500                 505                 510         

Gly Asn Ser Gly Pro Leu Pro Glu Glu Val Ala Lys Ala Ile Gln Glu 
        515                 520                 525             

Asn Asp Leu Leu Val Ser Ala Val Leu Ser Gly Asn Arg Asn Phe Glu 
    530                 535                 540                 

Gly Arg Ile His Ser Leu Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro 
545                 550                 555                 560 

Leu Val Val Ala Tyr Ala Ile Ala Gly Thr Val Asp Ile Asp Leu Val 
                565                 570                 575     

Asn Glu Pro Ile Gly Lys Asp Glu Asn Gly Asn Asp Val Phe Leu Arg 
            580                 585                 590         

Asp Ile Trp Pro Ser Asn Glu Glu Ile Gln Ala Val Ile Arg Gln Ile 
        595                 600                 605             

Ile Asn Pro Glu Met Phe Lys Lys Glu Tyr Glu Ser Val Phe Asn Arg 
    610                 615                 620                 

Asn Glu Arg Trp Asn Lys Leu Asp Val Pro Lys Gly Glu Leu Tyr Asp 
625                 630                 635                 640 

Trp Asp Pro Asn Ser Thr Tyr Ile Gln Glu Pro Pro Phe Phe Glu Gly 
                645                 650                 655     

Leu Ser Glu Glu Val Pro Asp Ile Gln Glu Ile Gln Gly Ala Arg Val 
            660                 665                 670         

Leu Ala Tyr Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala 
        675                 680                 685             

Gly Ser Ile Ala Pro Ser Ser Pro Ala Gly Gln Tyr Leu Gln Ser Lys 
    690                 695                 700                 

Gly Val Lys Pro His Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn 
705                 710                 715                 720 

His Glu Val Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Arg Asn 
                725                 730                 735     

Lys Val Ala Pro Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Phe Pro Thr 
            740                 745                 750         

Gly Glu Val Met Pro Ile Tyr Asp Ala Ala Met Lys Tyr Lys Ala Asp 
        755                 760                 765             

Gly Thr Pro Leu Val Val Ile Ala Gly Lys Glu Tyr Gly Thr Gly Ser 
    770                 775                 780                 

Ser Arg Asp Trp Ala Ala Lys Gly Thr Tyr Leu Leu Gly Val Lys Ala 
785                 790                 795                 800 

Val Ile Ala Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Gly 
                805                 810                 815     

Met Gly Val Leu Pro Leu Glu Phe Ile Asp Gly Gln Asn Ala Glu Thr 
            820                 825                 830         

Leu Gly Leu Thr Gly Arg Glu Val Tyr Thr Ile Lys Gly Leu Ser Asn 
        835                 840                 845             

Asp Leu Lys Pro Arg Gln Thr Val Thr Val Glu Val Thr Arg Glu Asp 
    850                 855                 860                 

Gly Ser Ser Phe Thr Phe Gln Ala Leu Val Arg Leu Asp Ser Asp Ile 
865                 870                 875                 880 

Glu Val Asp Tyr Tyr Arg Asn Gly Gly Ile Leu Gln Thr Val Leu Arg 
                885                 890                 895     

Asn Phe Met Arg Glu Gln His Ala 
            900                 

<210>   961
<211>   904
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 953

<400>   961
Met Gly Ala Asn Leu Phe Gln Ala Lys Gln Thr Leu Thr Val Gly Gly 
                5                   10                  15      

Lys Ser Tyr Thr Tyr Tyr Arg Leu Asp Ala Leu Gln Glu Gln Gly Val 
            20                  25                  30          

Ala Asp Ile Ser Arg Leu Pro Ile Ser Ile Lys Ile Leu Leu Glu Ser 
        35                  40                  45              

Val Leu Arg Gln Tyr Asp Gly Arg Val Ile Thr Glu Glu His Val Arg 
    50                  55                  60                  

Glu Leu Ala Asn Trp Asn Ala Ala Asn Pro Ala Lys Ser Glu Val Pro 
65                  70                  75                  80  

Phe Lys Pro Ala Arg Ile Leu Leu Gln Asp Phe Thr Gly Val Pro Val 
                85                  90                  95      

Val Val Asp Leu Ala Ala Met Arg Thr Ala Met His Lys Leu Gly Gly 
            100                 105                 110         

Asn Pro Lys Arg Ile Asn Pro Leu Ile Pro Val Asp Leu Val Ile Asp 
        115                 120                 125             

His Ser Val Gln Val Asp Ala Phe Gly Ser Lys Glu Ala Leu Glu Phe 
    130                 135                 140                 

Asn Ile Ala Lys Glu Phe Glu Arg Asn Glu Glu Arg Tyr Arg Phe Leu 
145                 150                 155                 160 

Arg Trp Ala Gln Thr Ala Phe Asp Asn Phe Arg Ala Val Pro Pro Gly 
                165                 170                 175     

Met Gly Ile Val His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val 
            180                 185                 190         

Gln Glu Arg Thr Val Asp Gly Glu Gln Val Val Phe Pro Asp Ser Leu 
        195                 200                 205             

Val Gly Thr Asp Ser His Thr Thr Met Ile Asn Gly Val Gly Val Leu 
    210                 215                 220                 

Gly Trp Gly Val Gly Gly Ile Glu Ala Glu Ala Cys Met Leu Gly Gln 
225                 230                 235                 240 

Pro Leu Tyr Phe Val Gln Pro Glu Val Ile Gly Phe Lys Leu Thr Gly 
                245                 250                 255     

Lys Leu Pro Glu Gly Ala Thr Ala Thr Asp Leu Ala Leu Thr Val Val 
            260                 265                 270         

Asn Met Leu Arg Lys Lys Gly Val Val Gly Lys Phe Val Glu Phe Tyr 
        275                 280                 285             

Gly Ala Gly Leu Ser Asn Ile Ser Val Ala Asp Arg Ala Thr Ile Ala 
    290                 295                 300                 

Asn Met Ala Pro Glu Tyr Gly Ala Thr Met Gly Phe Phe Pro Ile Asp 
305                 310                 315                 320 

Gln Ala Thr Leu Asp Tyr Leu Arg Leu Thr Gly Arg Asp Glu Ser Leu 
                325                 330                 335     

Ile Gln Leu Val Glu Ala Tyr Ala Lys Ala Gln Gly Met Phe Arg Thr 
            340                 345                 350         

Asp Asp Met Pro Asp Pro Val Phe Thr Asp Thr Leu Glu Leu Asp Leu 
        355                 360                 365             

Gly Ser Ile Gln Pro Thr Met Ala Gly Pro Lys Arg Pro Gln Asp Lys 
    370                 375                 380                 

Ile Phe Leu Ser Asp Met Lys Asn Asn Phe Glu Ala Ala Leu Glu Lys 
385                 390                 395                 400 

Pro Val Ser Glu Gly Gly Phe Gly Leu Ala Asp Gln Arg Asp Lys Thr 
                405                 410                 415     

Ala Leu Val Gln Tyr Pro Asp Gly His Lys Asp Glu Leu His His Gly 
            420                 425                 430         

Ala Val Val Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro 
        435                 440                 445             

Ser Val Met Ile Gly Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Lys 
    450                 455                 460                 

Gly Leu Lys Thr Pro Arg Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser 
465                 470                 475                 480 

Arg Val Val Thr Asp Tyr Leu Glu Arg Ser Gly Leu Leu Glu Pro Leu 
                485                 490                 495     

Ser Lys Leu Gly Phe Asp Val Val Gly Tyr Gly Cys Thr Thr Cys Ile 
            500                 505                 510         

Gly Asn Ser Gly Pro Leu Pro Glu Glu Val Ala Lys Ala Ile Gln Glu 
        515                 520                 525             

Asn Asp Leu Leu Val Ser Ala Val Leu Ser Gly Asn Arg Asn Phe Glu 
    530                 535                 540                 

Gly Arg Ile His Ser Leu Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro 
545                 550                 555                 560 

Leu Val Val Ala Tyr Ala Ile Ala Gly Thr Val Asp Ile Asp Leu Ile 
                565                 570                 575     

Asn Glu Pro Ile Gly Lys Asp Glu Asn Gly Asn Asp Val Phe Leu Arg 
            580                 585                 590         

Asp Ile Trp Pro Ser Asn Glu Glu Ile Gln Ala Val Ile Arg Gln Ile 
        595                 600                 605             

Ile Asn Pro Glu Met Phe Lys Lys Glu Tyr Glu Ser Val Phe Asn Arg 
    610                 615                 620                 

Asn Glu Arg Trp Asn Lys Leu Asp Val Pro Lys Gly Glu Leu Tyr Glu 
625                 630                 635                 640 

Trp Asp Pro Asn Ser Thr Tyr Ile Gln Glu Pro Pro Phe Phe Glu Gly 
                645                 650                 655     

Leu Ser Glu Glu Val Pro Asp Ile Gln Glu Ile Gln Gly Ala Arg Val 
            660                 665                 670         

Leu Ala Tyr Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala 
        675                 680                 685             

Gly Ser Ile Ala Pro Ser Ser Pro Ala Gly Gln Tyr Leu Gln Ser Lys 
    690                 695                 700                 

Gly Val Lys Pro His Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn 
705                 710                 715                 720 

His Glu Val Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Arg Asn 
                725                 730                 735     

Lys Val Ala Pro Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Phe Pro Thr 
            740                 745                 750         

Gly Glu Val Met Pro Ile Tyr Asp Ala Ala Met Lys Tyr Lys Ala Asp 
        755                 760                 765             

Gly Thr Pro Leu Val Val Ile Ala Gly Lys Glu Tyr Gly Thr Gly Ser 
    770                 775                 780                 

Ser Arg Asp Trp Ala Ala Lys Gly Thr Tyr Leu Leu Gly Val Lys Ala 
785                 790                 795                 800 

Val Ile Ala Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Gly 
                805                 810                 815     

Met Gly Val Leu Pro Leu Glu Phe Ile Asp Gly Gln Asn Ala Glu Thr 
            820                 825                 830         

Leu Gly Leu Thr Gly Arg Glu Val Tyr Thr Ile Lys Gly Leu Ser Asn 
        835                 840                 845             

Asp Leu Lys Pro Arg Gln Thr Val Thr Val Glu Val Thr Arg Glu Asp 
    850                 855                 860                 

Gly Ser Ser Phe Thr Phe Gln Ala Leu Val Arg Leu Asp Ser Asp Ile 
865                 870                 875                 880 

Glu Val Asp Tyr Tyr Arg Asn Gly Gly Ile Leu Gln Thr Val Leu Arg 
                885                 890                 895     

Asn Phe Met Arg Glu Gln His Ala 
            900                 

<210>   962
<211>   904
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 953

<400>   962
Met Gly Ala Asn Leu Phe Gln Ala Lys Gln Thr Leu Thr Val Gly Gly 
                5                   10                  15      

Lys Ser Tyr Thr Tyr Tyr Arg Leu Asp Ala Leu Gln Glu Gln Gly Val 
            20                  25                  30          

Ala Asp Ile Ser Arg Leu Pro Ile Ser Ile Lys Ile Leu Leu Glu Ser 
        35                  40                  45              

Val Leu Arg Gln Tyr Asp Gly Arg Val Ile Thr Glu Glu His Val Arg 
    50                  55                  60                  

Glu Leu Ala Asn Trp Asn Ala Ala Asn Pro Ala Lys Ser Glu Val Pro 
65                  70                  75                  80  

Phe Lys Pro Ala Arg Ile Leu Leu Gln Asp Phe Thr Gly Val Pro Val 
                85                  90                  95      

Val Val Asp Leu Ala Ala Met Arg Thr Ala Met His Lys Leu Gly Gly 
            100                 105                 110         

Asn Pro Lys Arg Ile Asn Pro Leu Ile Pro Val Asp Leu Val Ile Asp 
        115                 120                 125             

His Ser Val Gln Val Asp Ala Phe Gly Ser Lys Glu Ala Leu Glu Phe 
    130                 135                 140                 

Asn Ile Ala Lys Glu Phe Glu Arg Asn Glu Glu Arg Tyr Arg Phe Leu 
145                 150                 155                 160 

Arg Trp Ala Gln Thr Ala Phe Asp Asn Phe Arg Ala Val Pro Pro Gly 
                165                 170                 175     

Met Gly Ile Val His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val 
            180                 185                 190         

Gln Glu Arg Thr Val Asp Gly Glu Gln Val Val Phe Pro Asp Ser Leu 
        195                 200                 205             

Val Gly Thr Asp Ser His Thr Thr Met Ile Asn Gly Val Gly Val Leu 
    210                 215                 220                 

Gly Trp Gly Val Gly Gly Ile Glu Ala Glu Ala Cys Met Leu Gly Gln 
225                 230                 235                 240 

Pro Leu Tyr Phe Val Gln Pro Glu Val Ile Gly Phe Lys Leu Thr Gly 
                245                 250                 255     

Lys Leu Pro Glu Gly Ala Thr Ala Thr Asp Leu Ala Leu Thr Val Val 
            260                 265                 270         

Asn Met Leu Arg Lys Lys Gly Val Val Gly Lys Phe Val Glu Phe Tyr 
        275                 280                 285             

Gly Ala Gly Leu Ser Asn Ile Ser Val Ala Asp Arg Ala Thr Ile Ala 
    290                 295                 300                 

Asn Met Ala Pro Glu Tyr Gly Ala Thr Met Gly Phe Phe Pro Ile Asp 
305                 310                 315                 320 

Gln Ala Thr Leu Asp Tyr Leu Arg Leu Thr Gly Arg Asp Glu Ser Leu 
                325                 330                 335     

Ile Gln Leu Val Glu Ala Tyr Ala Lys Ala Gln Gly Met Phe Arg Thr 
            340                 345                 350         

Asp Asp Met Pro Asp Pro Val Phe Thr Asp Thr Leu Glu Leu Asp Leu 
        355                 360                 365             

Gly Ser Ile Gln Pro Thr Met Ala Gly Pro Lys Arg Pro Gln Asp Lys 
    370                 375                 380                 

Ile Phe Leu Ser Asp Met Lys Asn Asn Phe Glu Ala Ala Leu Glu Lys 
385                 390                 395                 400 

Pro Val Ser Glu Gly Gly Phe Gly Leu Ala Asp Gln Arg Asp Lys Thr 
                405                 410                 415     

Ala Leu Val Gln Tyr Pro Asp Gly His Lys Asp Glu Leu His His Gly 
            420                 425                 430         

Ala Val Val Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro 
        435                 440                 445             

Ser Val Met Ile Gly Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Lys 
    450                 455                 460                 

Gly Leu Lys Thr Pro Arg Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser 
465                 470                 475                 480 

Arg Val Val Thr Asp Tyr Leu Glu Lys Ser Gly Leu Leu Glu Pro Leu 
                485                 490                 495     

Ser Lys Leu Gly Phe Asp Val Val Gly Tyr Gly Cys Thr Thr Cys Ile 
            500                 505                 510         

Gly Asn Ser Gly Pro Leu Pro Glu Glu Val Ala Lys Ala Ile Gln Glu 
        515                 520                 525             

Asn Asp Leu Leu Val Ser Ala Val Leu Ser Gly Asn Arg Asn Phe Glu 
    530                 535                 540                 

Gly Arg Ile His Ser Leu Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro 
545                 550                 555                 560 

Leu Val Val Ala Tyr Ala Ile Ala Gly Thr Val Asp Ile Asp Leu Val 
                565                 570                 575     

Asn Glu Pro Ile Gly Lys Asp Glu Asn Gly Asn Asp Val Phe Leu Arg 
            580                 585                 590         

Asp Ile Trp Pro Ser Asn Glu Glu Ile Gln Ala Val Ile Arg Gln Ile 
        595                 600                 605             

Ile Asn Pro Glu Met Phe Lys Lys Glu Tyr Glu Ser Val Phe Asn Arg 
    610                 615                 620                 

Asn Glu Arg Trp Asn Lys Leu Asp Val Pro Lys Gly Glu Leu Tyr Glu 
625                 630                 635                 640 

Trp Asp Pro Asn Ser Thr Tyr Ile Gln Glu Pro Pro Phe Phe Glu Gly 
                645                 650                 655     

Leu Ser Glu Glu Val Pro Asp Ile Gln Glu Ile Gln Gly Ala Arg Val 
            660                 665                 670         

Leu Ala Tyr Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala 
        675                 680                 685             

Gly Ser Ile Ala Pro Ser Ser Pro Ala Gly Gln Tyr Leu Gln Ser Lys 
    690                 695                 700                 

Gly Val Lys Pro His Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn 
705                 710                 715                 720 

His Glu Val Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Arg Asn 
                725                 730                 735     

Lys Val Ala Pro Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Phe Pro Thr 
            740                 745                 750         

Gly Glu Val Met Pro Ile Tyr Asp Ala Ala Met Lys Tyr Lys Ala Asp 
        755                 760                 765             

Gly Thr Pro Leu Val Val Ile Ala Gly Lys Glu Tyr Gly Thr Gly Ser 
    770                 775                 780                 

Ser Arg Asp Trp Ala Ala Lys Gly Thr Tyr Leu Leu Gly Val Lys Ala 
785                 790                 795                 800 

Val Ile Ala Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Gly 
                805                 810                 815     

Met Gly Val Leu Pro Leu Glu Phe Ile Asp Gly Gln Asn Ala Glu Thr 
            820                 825                 830         

Leu Gly Leu Thr Gly Arg Glu Val Tyr Thr Ile Lys Gly Leu Ser Asn 
        835                 840                 845             

Asp Leu Lys Pro Arg Gln Thr Val Thr Val Glu Val Thr Arg Glu Asp 
    850                 855                 860                 

Gly Ser Ser Phe Thr Phe Gln Ala Leu Val Arg Leu Asp Ser Asp Ile 
865                 870                 875                 880 

Glu Val Asp Tyr Tyr Arg Asn Gly Gly Ile Leu Gln Thr Val Leu Arg 
                885                 890                 895     

Asn Phe Met Arg Glu Gln His Ala 
            900                 

<210>   963
<211>   904
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 953

<400>   963
Met Gly Ala Asn Leu Phe Gln Ala Lys Gln Thr Leu Thr Val Gly Gly 
                5                   10                  15      

Lys Ser Tyr Thr Tyr Tyr Arg Leu Asp Ala Leu Gln Glu Gln Gly Val 
            20                  25                  30          

Ala Asp Ile Ser Arg Leu Pro Ile Ser Ile Lys Ile Leu Leu Glu Ser 
        35                  40                  45              

Val Leu Arg Gln Tyr Asp Gly Arg Val Ile Thr Glu Glu His Val Arg 
    50                  55                  60                  

Glu Leu Ala Asn Trp Asn Ala Ala Asn Pro Ala Lys Ser Glu Val Pro 
65                  70                  75                  80  

Phe Lys Pro Ala Arg Ile Leu Leu Gln Asp Phe Thr Gly Val Pro Val 
                85                  90                  95      

Val Val Asp Leu Ala Ala Met Arg Thr Ala Met His Lys Leu Gly Gly 
            100                 105                 110         

Asn Pro Lys Arg Ile Asn Pro Leu Ile Pro Val Asp Leu Val Ile Asp 
        115                 120                 125             

His Ser Val Gln Val Asp Ala Phe Gly Ser Lys Glu Ala Leu Glu Phe 
    130                 135                 140                 

Asn Ile Ala Lys Glu Phe Glu Arg Asn Glu Glu Arg Tyr Arg Phe Leu 
145                 150                 155                 160 

Arg Trp Ala Gln Thr Ala Phe Asp Asn Phe Arg Ala Val Pro Pro Gly 
                165                 170                 175     

Met Gly Ile Val His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val 
            180                 185                 190         

Gln Glu Arg Thr Val Asp Gly Glu Gln Val Val Phe Pro Asp Ser Leu 
        195                 200                 205             

Val Gly Thr Asp Ser His Thr Thr Met Ile Asn Gly Val Gly Val Leu 
    210                 215                 220                 

Gly Trp Gly Val Gly Gly Ile Glu Ala Glu Ala Cys Met Leu Gly Gln 
225                 230                 235                 240 

Pro Leu Tyr Phe Val Gln Pro Glu Val Ile Gly Phe Lys Leu Thr Gly 
                245                 250                 255     

Lys Leu Pro Glu Gly Ala Thr Ala Thr Asp Leu Ala Leu Thr Val Val 
            260                 265                 270         

Asn Met Leu Arg Lys Lys Gly Val Val Gly Lys Phe Val Glu Phe Tyr 
        275                 280                 285             

Gly Ala Gly Leu Ser Asn Ile Ser Val Ala Asp Arg Ala Thr Ile Ala 
    290                 295                 300                 

Asn Met Ala Pro Glu Tyr Gly Ala Thr Met Gly Phe Phe Pro Ile Asp 
305                 310                 315                 320 

Gln Ala Thr Leu Asp Tyr Leu Arg Leu Thr Gly Arg Asp Glu Ser Leu 
                325                 330                 335     

Ile Gln Leu Val Glu Ala Tyr Ala Lys Ala Gln Gly Met Phe Arg Thr 
            340                 345                 350         

Asp Asp Met Pro Asp Pro Val Phe Thr Asp Thr Leu Glu Leu Asp Leu 
        355                 360                 365             

Gly Ser Ile Gln Pro Thr Met Ala Gly Pro Lys Arg Pro Gln Asp Lys 
    370                 375                 380                 

Ile Phe Leu Ser Asp Met Lys Asn Asn Phe Glu Ala Ala Leu Glu Lys 
385                 390                 395                 400 

Pro Val Ser Glu Gly Gly Phe Gly Leu Ala Asp Gln Arg Asp Lys Thr 
                405                 410                 415     

Ala Leu Val Gln Tyr Pro Asp Gly His Lys Asp Glu Leu His His Gly 
            420                 425                 430         

Ala Val Val Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro 
        435                 440                 445             

Ser Val Met Ile Gly Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Lys 
    450                 455                 460                 

Gly Leu Lys Thr Pro Arg Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser 
465                 470                 475                 480 

Arg Val Val Thr Asp Tyr Leu Glu Arg Ser Gly Leu Leu Glu Pro Leu 
                485                 490                 495     

Ser Lys Leu Gly Phe Asp Val Val Gly Tyr Gly Cys Thr Thr Cys Ile 
            500                 505                 510         

Gly Asn Ser Gly Pro Leu Pro Glu Glu Val Ala Lys Ala Ile Gln Glu 
        515                 520                 525             

Asn Asp Leu Leu Val Ser Ala Val Leu Ser Gly Asn Arg Asn Phe Glu 
    530                 535                 540                 

Gly Arg Ile His Ser Leu Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro 
545                 550                 555                 560 

Leu Val Val Ala Tyr Ala Ile Ala Gly Thr Val Asp Ile Asp Leu Val 
                565                 570                 575     

Asn Glu Pro Ile Gly Lys Asp Glu Asn Gly Asn Asp Val Phe Leu Arg 
            580                 585                 590         

Asp Ile Trp Pro Ser Asn Glu Glu Ile Gln Ala Val Ile Arg Gln Ile 
        595                 600                 605             

Ile Gln Pro Glu Met Phe Lys Lys Glu Tyr Glu Ser Val Phe Asn Arg 
    610                 615                 620                 

Asn Glu Arg Trp Asn Lys Leu Asp Val Pro Lys Gly Glu Leu Tyr Glu 
625                 630                 635                 640 

Trp Asp Pro Asn Ser Thr Tyr Ile Gln Glu Pro Pro Phe Phe Glu Gly 
                645                 650                 655     

Leu Ser Glu Glu Val Pro Asp Ile Gln Glu Ile Gln Gly Ala Arg Val 
            660                 665                 670         

Leu Ala Tyr Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala 
        675                 680                 685             

Gly Ser Ile Ala Pro Ser Ser Pro Ala Gly Gln Tyr Leu Gln Ser Lys 
    690                 695                 700                 

Gly Val Lys Pro His Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn 
705                 710                 715                 720 

His Glu Val Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Arg Asn 
                725                 730                 735     

Lys Val Ala Pro Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Phe Pro Thr 
            740                 745                 750         

Gly Glu Val Met Pro Ile Tyr Asp Ala Ala Met Lys Tyr Lys Ala Asp 
        755                 760                 765             

Gly Thr Pro Leu Val Val Ile Ala Gly Lys Glu Tyr Gly Thr Gly Ser 
    770                 775                 780                 

Ser Arg Asp Trp Ala Ala Lys Gly Thr Tyr Leu Leu Gly Val Lys Ala 
785                 790                 795                 800 

Val Ile Ala Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Gly 
                805                 810                 815     

Met Gly Val Leu Pro Leu Glu Phe Ile Asp Gly Gln Asn Ala Glu Thr 
            820                 825                 830         

Leu Gly Leu Thr Gly Arg Glu Val Tyr Thr Ile Lys Gly Leu Ser Asn 
        835                 840                 845             

Asp Leu Lys Pro Arg Gln Thr Val Thr Val Glu Val Thr Arg Glu Asp 
    850                 855                 860                 

Gly Ser Ser Phe Thr Phe Gln Ala Leu Val Arg Leu Asp Ser Asp Ile 
865                 870                 875                 880 

Glu Val Asp Tyr Tyr Arg Asn Gly Gly Ile Leu Gln Thr Val Leu Arg 
                885                 890                 895     

Asn Phe Met Arg Glu Gln His Ala 
            900                 

<210>   964
<211>   904
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 953

<400>   964
Met Gly Ala Asn Leu Phe Gln Ala Lys Gln Thr Leu Thr Val Gly Gly 
                5                   10                  15      

Lys Ser Tyr Thr Tyr Tyr Arg Leu Asp Ala Leu Gln Glu Gln Gly Val 
            20                  25                  30          

Ala Asp Ile Ser Arg Leu Pro Ile Ser Ile Lys Ile Leu Leu Glu Ser 
        35                  40                  45              

Val Leu Arg Gln Tyr Asp Gly Arg Val Ile Thr Glu Glu His Val Arg 
    50                  55                  60                  

Glu Leu Ala Asn Trp Asn Ala Ala Asn Pro Ala Lys Ser Glu Val Pro 
65                  70                  75                  80  

Phe Lys Pro Ala Arg Ile Leu Leu Gln Asp Phe Thr Gly Val Pro Val 
                85                  90                  95      

Val Val Asp Leu Ala Ala Met Arg Thr Ala Met His Lys Leu Gly Gly 
            100                 105                 110         

Asn Pro Lys Arg Ile Asn Pro Leu Ile Pro Val Asp Leu Val Ile Asp 
        115                 120                 125             

His Ser Val Gln Val Asp Ala Phe Gly Ser Lys Glu Ala Leu Glu Phe 
    130                 135                 140                 

Asn Ile Ala Lys Glu Phe Glu Arg Asn Glu Glu Arg Tyr Arg Phe Leu 
145                 150                 155                 160 

Arg Trp Ala Gln Thr Ala Phe Asp Asn Phe Arg Ala Val Pro Pro Gly 
                165                 170                 175     

Met Gly Ile Val His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val 
            180                 185                 190         

Gln Glu Arg Thr Val Asp Gly Glu Gln Val Val Phe Pro Asp Ser Leu 
        195                 200                 205             

Val Gly Thr Asp Ser His Thr Thr Met Ile Asn Gly Val Gly Val Leu 
    210                 215                 220                 

Gly Trp Gly Val Gly Gly Ile Glu Ala Glu Ala Cys Met Leu Gly Gln 
225                 230                 235                 240 

Pro Leu Tyr Phe Ile Gln Pro Glu Val Ile Gly Phe Lys Leu Thr Gly 
                245                 250                 255     

Lys Leu Pro Glu Gly Ala Thr Ala Thr Asp Leu Ala Leu Thr Val Val 
            260                 265                 270         

Asn Met Leu Arg Lys Lys Gly Val Val Gly Lys Phe Val Glu Phe Tyr 
        275                 280                 285             

Gly Ala Gly Leu Ser Asn Ile Ser Val Ala Asp Arg Ala Thr Ile Ala 
    290                 295                 300                 

Asn Met Ala Pro Glu Tyr Gly Ala Thr Met Gly Phe Phe Pro Ile Asp 
305                 310                 315                 320 

Gln Ala Thr Leu Asp Tyr Leu Arg Leu Thr Gly Arg Asp Glu Ser Leu 
                325                 330                 335     

Ile Gln Leu Val Glu Ala Tyr Ala Lys Ala Gln Gly Met Phe Arg Thr 
            340                 345                 350         

Asp Asp Met Pro Asp Pro Val Phe Thr Asp Thr Leu Glu Leu Asp Leu 
        355                 360                 365             

Gly Ser Ile Gln Pro Thr Met Ala Gly Pro Lys Arg Pro Gln Asp Lys 
    370                 375                 380                 

Ile Phe Leu Ser Asp Met Lys Asn Asn Phe Glu Ala Ala Leu Glu Lys 
385                 390                 395                 400 

Pro Val Ser Glu Gly Gly Phe Gly Leu Ala Asp Gln Arg Asp Lys Thr 
                405                 410                 415     

Ala Leu Val Gln Tyr Pro Asp Gly His Lys Asp Glu Leu His His Gly 
            420                 425                 430         

Ala Val Val Ile Ala Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro 
        435                 440                 445             

Ser Val Met Ile Gly Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Lys 
    450                 455                 460                 

Gly Leu Lys Thr Pro Arg Tyr Val Lys Thr Ser Leu Ala Pro Gly Ser 
465                 470                 475                 480 

Arg Val Val Thr Asp Tyr Leu Glu Arg Ser Gly Leu Leu Glu Pro Leu 
                485                 490                 495     

Ser Lys Leu Gly Phe Asp Val Val Gly Tyr Gly Cys Thr Thr Cys Ile 
            500                 505                 510         

Gly Asn Ser Gly Pro Leu Pro Glu Glu Val Ala Lys Ala Ile Gln Glu 
        515                 520                 525             

Asn Asp Leu Leu Val Ser Ala Val Leu Ser Gly Asn Arg Asn Phe Glu 
    530                 535                 540                 

Gly Arg Ile His Ser Leu Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro 
545                 550                 555                 560 

Leu Val Val Ala Tyr Ala Ile Ala Gly Thr Val Asp Ile Asp Leu Val 
                565                 570                 575     

Asn Glu Pro Ile Gly Lys Asp Glu Asn Gly Asn Asp Val Phe Leu Arg 
            580                 585                 590         

Asp Ile Trp Pro Ser Asn Glu Glu Ile Gln Ala Val Ile Arg Gln Ile 
        595                 600                 605             

Ile Asn Pro Glu Met Phe Lys Lys Glu Tyr Glu Ser Val Phe Asn Arg 
    610                 615                 620                 

Asn Glu Arg Trp Asn Lys Leu Asp Val Pro Lys Gly Glu Leu Tyr Glu 
625                 630                 635                 640 

Trp Asp Pro Asn Ser Thr Tyr Ile Gln Glu Pro Pro Phe Phe Glu Gly 
                645                 650                 655     

Leu Ser Glu Glu Val Pro Asp Ile Gln Glu Ile Gln Gly Ala Arg Val 
            660                 665                 670         

Leu Ala Tyr Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala 
        675                 680                 685             

Gly Ser Ile Ala Pro Ser Ser Pro Ala Gly Gln Tyr Leu Gln Ser Lys 
    690                 695                 700                 

Gly Val Lys Pro His Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn 
705                 710                 715                 720 

His Glu Val Met Met Arg Gly Thr Phe Ala Asn Ile Arg Ile Arg Asn 
                725                 730                 735     

Lys Val Ala Pro Gly Thr Glu Gly Gly Tyr Thr Thr Tyr Phe Pro Thr 
            740                 745                 750         

Gly Glu Val Met Pro Ile Tyr Asp Ala Ala Met Lys Tyr Lys Ala Asp 
        755                 760                 765             

Gly Thr Pro Leu Val Val Ile Ala Gly Lys Glu Tyr Gly Thr Gly Ser 
    770                 775                 780                 

Ser Arg Asp Trp Ala Ala Lys Gly Thr Tyr Leu Leu Gly Val Lys Ala 
785                 790                 795                 800 

Val Ile Ala Glu Ser Phe Glu Arg Ile His Arg Ser Asn Leu Val Gly 
                805                 810                 815     

Met Gly Val Leu Pro Leu Glu Phe Ile Asp Gly Gln Asn Ala Glu Thr 
            820                 825                 830         

Leu Gly Leu Thr Gly Arg Glu Val Tyr Thr Ile Lys Gly Leu Ser Asn 
        835                 840                 845             

Asp Leu Lys Pro Arg Gln Thr Val Thr Val Glu Val Thr Arg Glu Asp 
    850                 855                 860                 

Gly Ser Ser Phe Thr Phe Gln Ala Leu Val Arg Leu Asp Ser Asp Ile 
865                 870                 875                 880 

Glu Val Asp Tyr Tyr Arg Asn Gly Gly Ile Leu Gln Thr Val Leu Arg 
                885                 890                 895     

Asn Phe Met Arg Glu Gln His Ala 
            900                 

<210>   965
<211>   2715
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 954

<400>   965
gtgggcgcca atctgtttca agccaaacag accctcaccg ttggcgggaa gtcctatacc       60

tactaccgcc tggacgctct tcaggagcaa ggcgtagccg acatctcccg cctccccatt      120

tccatcaaaa ttctgcttga atccgtgctt cgccagtacg atggccgcgt catcacggag      180

gagcacgtgc gcgaactcgc caactggaac gcggcgaacc cggcgaaatc cgaggtccct      240

tttaagcccg cgcgcatcct gctgcaggat ttcacgggcg tgcctgtcgt ggtggatctg      300

gccgccatgc gcacggcgat gcacaagctc ggcggcaatc cgaagcggat caacccgctc      360

atcccggtcg atctcgtcat cgaccactcg gtgcaggtgg acgcgttcgg ttccaaagag      420

gcgctggagt tcaacatcgc gaaggaattc gagcgcaacg aggagcgcta ccgcttcctc      480

cgctgggcac aaacggcgtt cgacaacttc cgcgcggtgc cacccggaat gggcatcgtc      540

caccaggtca acctggagta cctcgcgcgc gtggtccagg agcggaccgt cgacggcgag      600

caagtcgtct tcccggatag cctcgtcggc accgactcgc acacgaccat gatcaacggc      660

gtcggcgtcc tcggctgggg cgtgggcggc atcgaggccg aggcgtgcat gctcggtcag      720

cccttgtact tcgtgcagcc cgaggtcatc ggcttcaagc tgaccggcaa actgcccgag      780

ggcgcgaccg cgaccgatct cgccctgact gtcgtgaaca tgctgcgcaa gaagggcgtc      840

gtcggcaagt tcgtcgagtt ctacggcgcc ggcctctcca acatcagcgt cgctgaccgc      900

gcgaccatcg ccaacatggc gcccgagtac ggtgcgacga tgggcttctt ccccatcgac      960

caggcgacgc tcgactatct ccgcctgacc ggccgcgacg aatcgctcat ccagctcgtc     1020

gaggcgtacg cgaaggcaca gggtatgttc cgcacggacg acatgccgga tcccgtcttc     1080

accgacacgc tggagctcga tctcggctcc atccagccga cgatggcggg tccgaagcgg     1140

ccgcaggata agatcttcct ctccgatatg aagaacaact tcgaggcggc gctcgagaag     1200

ccggtgtcgg agggcggttt cgggcttgcg gaccagcggg ataagacggc ccttgtccaa     1260

tatccggacg ggcacaagga cgaactccac cacggcgcgg tcgtgatcgc cgccatcacg     1320

agctgcacca acacctccaa cccgtccgtg atgattggcg cggggctgtt ggcgaagaag     1380

gccgtggaga aggggctgaa gacgccgcgc tacgtgaaga cgtcgctcgc gccgggatcg     1440

cgcgtcgtca cggattacct ggagcgctcg ggcctgctcg agccactctc caagctcggc     1500

tttgacgtgg tcggctacgg ctgtaccacg tgcatcggaa acagcggccc gctgccggag     1560

gaagtggcca aggcgattca ggagaacgac ctcctggtct ccgcggtgtt gtcgggcaac     1620

cgcaacttcg aggggcgcat ccactcgctc gttcgcgcca actatctcgc ttcgccgccg     1680

ctcgtcgtgg cgtacgctat cgcgggcacg gtggacatcg atctcgtcaa cgagcccatc     1740

ggcaaggacg agaacggcaa cgacgtgttc ctgagggaca tctggccgtc gaacgaggag     1800

attcaggcgg tcatccggca aatcatcaat ccggagatgt tcaagaagga atacgagagc     1860

gtgttcaacc ggaacgagcg gtggaacaag ctggacgtcc cgaagggcga gctgtacgat     1920

tgggatccga attcgacgta catccaggag ccgccgttct tcgaggggct gtcggaagag     1980

gttccggaca tccaggagat ccaaggcgcg cgcgtgctcg cgtacctggg cgactcggtg     2040

acgacggacc acatctcgcc cgcgggcagc atcgcgccgt cgagcccggc tggccagtac     2100

ctgcagtcca agggcgtgaa gccgcatgag ttcaactcgt acggttcgcg ccgcggcaac     2160

cacgaggtca tgatgcgcgg cacgttcgcg aacatccgca ttcgcaacaa ggtggcgcct     2220

ggcacggagg gcggttacac gacgtacttc ccgacgggcg aagtgatgcc gatttacgac     2280

gcggcgatga agtacaaggc ggatggcacg ccgctcgtgg tcatcgccgg caaggagtac     2340

ggaacaggct cgtcccgcga ctgggcggcg aagggcacct acttgctcgg cgtgaaggcc     2400

gtgatcgcgg agagcttcga gcgcatccac cggagcaacc tggtcggcat gggcgtgctg     2460

ccgctcgagt tcatcgacgg gcaaaacgcg gagacgcttg gcctgaccgg ccgcgaggtg     2520

tacaccatca aggggctgtc gaacgacctg aagccgcgcc agacggtcac ggtcgaagtc     2580

acgcgcgaag acggatcgtc gttcacgttc caagcgctcg tgcggctcga cagcgacatc     2640

gaggtggatt actaccgcaa cggcggtatc ctgcagacag tgctccgcaa cttcatgcgc     2700

gagcaacacg cgtaa                                                      2715


<210>   966
<211>   2715
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 954

<400>   966
gtgggcgcca atctgtttca agccaaacag accctcaccg ttggcgggaa gtcctatacc       60

tactaccgcc tggacgctct tcaggagcaa ggcgtagccg acatctcccg cctccccatt      120

tccatcaaaa ttctgcttga atccgtgctt cgccagtacg atggccgcgt catcacggag      180

gagcacgtgc gcgaactcgc caactggaac gcggcgaacc cggcgaaatc cgaggtccct      240

tttaagcccg cgcgcatcct gctgcaggat ttcacgggcg tgcctgtcgt ggtggatctg      300

gccgccatgc gcacggcgat gcacaagctc ggcggcaatc cgaagcggat caacccgctc      360

atcccggtcg atctcgtcat cgaccactcg gtgcaggtgg acgcgttcgg ttccaaagag      420

gcgctggagt tcaacatcgc gaaggaattc gagcgcaacg aggagcgcta ccgcttcctc      480

cgctgggcac aaacggcgtt cgacaacttc cgcgcggtgc cacccggaat gggcatcgtc      540

caccaggtca acctggagta cctcgcgcgc gtggtccagg agcggaccgt cgacggcgag      600

caagtcgtct tcccggatag cctcgtcggc accgactcgc acacgaccat gatcaacggc      660

gtcggcgtcc tcggctgggg cgtgggcggc atcgaggccg aggcgtgcat gctcggtcag      720

cccttgtact tcgtgcagcc cgaggtcatc ggcttcaagc tgaccggcaa actgcccgag      780

ggcgcgaccg cgaccgatct cgccctgact gtcgtgaaca tgctgcgcaa gaagggcgtc      840

gtcggcaagt tcgtcgagtt ctacggcgcc ggcctctcca acatcagcgt cgctgaccgc      900

gcgaccatcg ccaacatggc gcccgagtac ggtgcgacga tgggcttctt ccccatcgac      960

caggcgacgc tcgactatct ccgcctgacc ggccgcgacg aatcgctcat ccagctcgtc     1020

gaggcgtacg cgaaggcaca gggtatgttc cgcacggacg acatgccgga tcccgtcttc     1080

accgacacgc tggagctcga tctcggctcc atccagccga cgatggcggg tccgaagcgg     1140

ccgcaggata agatcttcct ctccgatatg aagaacaact tcgaggcggc gctcgagaag     1200

ccggtgtcgg agggcggttt cgggcttgcg gaccagcggg ataagacggc ccttgtccaa     1260

tatccggacg ggcacaagga cgaactccac cacggcgcgg tcgtgatcgc cgccatcacg     1320

agctgcacca acacctccaa cccgtccgtg atgattggcg cggggctgtt ggcgaagaag     1380

gccgtggaga aggggctgaa gacgccgcgc tacgtgaaga cgtcgctcgc gccgggatcg     1440

cgcgtcgtca cggattacct ggagcgctcg ggcctgctcg agccactctc caagctcggc     1500

tttgacgtgg tcggctacgg ctgtaccacg tgcatcggaa acagcggccc gctgccggag     1560

gaagtggcca aggcgattca ggagaacgac ctcctggtct ccgcggtgtt gtcgggcaac     1620

cgcaacttcg aggggcgcat ccactcgctc gttcgcgcca actatctcgc ttcgccgccg     1680

ctcgtcgtgg cgtacgctat cgcgggcacg gtggacatcg atctcattaa cgagcccatc     1740

ggcaaggacg agaacggcaa cgacgtgttc ctgagggaca tctggccgtc gaacgaggag     1800

attcaggcgg tcatccggca aatcatcaat ccggagatgt tcaagaagga atacgagagc     1860

gtgttcaacc ggaacgagcg gtggaacaag ctggacgtcc cgaagggcga gctgtacgaa     1920

tgggatccga attcgacgta catccaggag ccgccgttct tcgaggggct gtcggaagag     1980

gttccggaca tccaggagat ccaaggcgcg cgcgtgctcg cgtacctggg cgactcggtg     2040

acgacggacc acatctcgcc cgcgggcagc atcgcgccgt cgagcccggc tggccagtac     2100

ctgcagtcca agggcgtgaa gccgcatgag ttcaactcgt acggttcgcg ccgcggcaac     2160

cacgaggtca tgatgcgcgg cacgttcgcg aacatccgca ttcgcaacaa ggtggcgcct     2220

ggcacggagg gcggttacac gacgtacttc ccgacgggcg aagtgatgcc gatttacgac     2280

gcggcgatga agtacaaggc ggatggcacg ccgctcgtgg tcatcgccgg caaggagtac     2340

ggaacaggct cgtcccgcga ctgggcggcg aagggcacct acttgctcgg cgtgaaggcc     2400

gtgatcgcgg agagcttcga gcgcatccac cggagcaacc tggtcggcat gggcgtgctg     2460

ccgctcgagt tcatcgacgg gcaaaacgcg gagacgcttg gcctgaccgg ccgcgaggtg     2520

tacaccatca aggggctgtc gaacgacctg aagccgcgcc agacggtcac ggtcgaagtc     2580

acgcgcgaag acggatcgtc gttcacgttc caagcgctcg tgcggctcga cagcgacatc     2640

gaggtggatt actaccgcaa cggcggtatc ctgcagacag tgctccgcaa cttcatgcgc     2700

gagcaacacg cgtaa                                                      2715


<210>   967
<211>   2715
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 954

<400>   967
gtgggcgcca atctgtttca agccaaacag accctcaccg ttggcgggaa gtcctatacc       60

tactaccgcc tggacgctct tcaggagcaa ggcgtagccg acatctcccg cctccccatt      120

tccatcaaaa ttctgcttga atccgtgctt cgccagtacg atggccgcgt catcacggag      180

gagcacgtgc gcgaactcgc caactggaac gcggcgaacc cggcgaaatc cgaggtccct      240

tttaagcccg cgcgcatcct gctgcaggat ttcacgggcg tgcctgtcgt ggtggatctg      300

gccgccatgc gcacggcgat gcacaagctc ggcggcaatc cgaagcggat caacccgctc      360

atcccggtcg atctcgtcat cgaccactcg gtgcaggtgg acgcgttcgg ttccaaagag      420

gcgctggagt tcaacatcgc gaaggaattc gagcgcaacg aggagcgcta ccgcttcctc      480

cgctgggcac aaacggcgtt cgacaacttc cgcgcggtgc cacccggaat gggcatcgtc      540

caccaggtca acctggagta cctcgcgcgc gtggtccagg agcggaccgt cgacggcgag      600

caagtcgtct tcccggatag cctcgtcggc accgactcgc acacgaccat gatcaacggc      660

gtcggcgtcc tcggctgggg cgtgggcggc atcgaggccg aggcgtgcat gctcggtcag      720

cccttgtact tcgtgcagcc cgaggtcatc ggcttcaagc tgaccggcaa actgcccgag      780

ggcgcgaccg cgaccgatct cgccctgact gtcgtgaaca tgctgcgcaa gaagggcgtc      840

gtcggcaagt tcgtcgagtt ctacggcgcc ggcctctcca acatcagcgt cgctgaccgc      900

gcgaccatcg ccaacatggc gcccgagtac ggtgcgacga tgggcttctt ccccatcgac      960

caggcgacgc tcgactatct ccgcctgacc ggccgcgacg aatcgctcat ccagctcgtc     1020

gaggcgtacg cgaaggcaca gggtatgttc cgcacggacg acatgccgga tcccgtcttc     1080

accgacacgc tggagctcga tctcggctcc atccagccga cgatggcggg tccgaagcgg     1140

ccgcaggata agatcttcct ctccgatatg aagaacaact tcgaggcggc gctcgagaag     1200

ccggtgtcgg agggcggttt cgggcttgcg gaccagcggg ataagacggc ccttgtccaa     1260

tatccggacg ggcacaagga cgaactccac cacggcgcgg tcgtgatcgc cgccatcacg     1320

agctgcacca acacctccaa cccgtccgtg atgattggcg cggggctgtt ggcgaagaag     1380

gccgtggaga aggggctgaa gacgccgcgc tacgtgaaga cgtcgctcgc gccgggatcg     1440

cgcgtcgtca cggattacct ggagaaatcg ggcctgctcg agccactctc caagctcggc     1500

tttgacgtgg tcggctacgg ctgtaccacg tgcatcggaa acagcggccc gctgccggag     1560

gaagtggcca aggcgattca ggagaacgac ctcctggtct ccgcggtgtt gtcgggcaac     1620

cgcaacttcg aggggcgcat ccactcgctc gttcgcgcca actatctcgc ttcgccgccg     1680

ctcgtcgtgg cgtacgctat cgcgggcacg gtggacatcg atctcgtcaa cgagcccatc     1740

ggcaaggacg agaacggcaa cgacgtgttc ctgagggaca tctggccgtc gaacgaggag     1800

attcaggcgg tcatccggca aatcatcaat ccggagatgt tcaagaagga atacgagagc     1860

gtgttcaacc ggaacgagcg gtggaacaag ctggacgtcc cgaagggcga gctgtacgaa     1920

tgggatccga attcgacgta catccaggag ccgccgttct tcgaggggct gtcggaagag     1980

gttccggaca tccaggagat ccaaggcgcg cgcgtgctcg cgtacctggg cgactcggtg     2040

acgacggacc acatctcgcc cgcgggcagc atcgcgccgt cgagcccggc tggccagtac     2100

ctgcagtcca agggcgtgaa gccgcatgag ttcaactcgt acggttcgcg ccgcggcaac     2160

cacgaggtca tgatgcgcgg cacgttcgcg aacatccgca ttcgcaacaa ggtggcgcct     2220

ggcacggagg gcggttacac gacgtacttc ccgacgggcg aagtgatgcc gatttacgac     2280

gcggcgatga agtacaaggc ggatggcacg ccgctcgtgg tcatcgccgg caaggagtac     2340

ggaacaggct cgtcccgcga ctgggcggcg aagggcacct acttgctcgg cgtgaaggcc     2400

gtgatcgcgg agagcttcga gcgcatccac cggagcaacc tggtcggcat gggcgtgctg     2460

ccgctcgagt tcatcgacgg gcaaaacgcg gagacgcttg gcctgaccgg ccgcgaggtg     2520

tacaccatca aggggctgtc gaacgacctg aagccgcgcc agacggtcac ggtcgaagtc     2580

acgcgcgaag acggatcgtc gttcacgttc caagcgctcg tgcggctcga cagcgacatc     2640

gaggtggatt actaccgcaa cggcggtatc ctgcagacag tgctccgcaa cttcatgcgc     2700

gagcaacacg cgtaa                                                      2715


<210>   968
<211>   2715
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 954

<400>   968
gtgggcgcca atctgtttca agccaaacag accctcaccg ttggcgggaa gtcctatacc       60

tactaccgcc tggacgctct tcaggagcaa ggcgtagccg acatctcccg cctccccatt      120

tccatcaaaa ttctgcttga atccgtgctt cgccagtacg atggccgcgt catcacggag      180

gagcacgtgc gcgaactcgc caactggaac gcggcgaacc cggcgaaatc cgaggtccct      240

tttaagcccg cgcgcatcct gctgcaggat ttcacgggcg tgcctgtcgt ggtggatctg      300

gccgccatgc gcacggcgat gcacaagctc ggcggcaatc cgaagcggat caacccgctc      360

atcccggtcg atctcgtcat cgaccactcg gtgcaggtgg acgcgttcgg ttccaaagag      420

gcgctggagt tcaacatcgc gaaggaattc gagcgcaacg aggagcgcta ccgcttcctc      480

cgctgggcac aaacggcgtt cgacaacttc cgcgcggtgc cacccggaat gggcatcgtc      540

caccaggtca acctggagta cctcgcgcgc gtggtccagg agcggaccgt cgacggcgag      600

caagtcgtct tcccggatag cctcgtcggc accgactcgc acacgaccat gatcaacggc      660

gtcggcgtcc tcggctgggg cgtgggcggc atcgaggccg aggcgtgcat gctcggtcag      720

cccttgtact tcgtgcagcc cgaggtcatc ggcttcaagc tgaccggcaa actgcccgag      780

ggcgcgaccg cgaccgatct cgccctgact gtcgtgaaca tgctgcgcaa gaagggcgtc      840

gtcggcaagt tcgtcgagtt ctacggcgcc ggcctctcca acatcagcgt cgctgaccgc      900

gcgaccatcg ccaacatggc gcccgagtac ggtgcgacga tgggcttctt ccccatcgac      960

caggcgacgc tcgactatct ccgcctgacc ggccgcgacg aatcgctcat ccagctcgtc     1020

gaggcgtacg cgaaggcaca gggtatgttc cgcacggacg acatgccgga tcccgtcttc     1080

accgacacgc tggagctcga tctcggctcc atccagccga cgatggcggg tccgaagcgg     1140

ccgcaggata agatcttcct ctccgatatg aagaacaact tcgaggcggc gctcgagaag     1200

ccggtgtcgg agggcggttt cgggcttgcg gaccagcggg ataagacggc ccttgtccaa     1260

tatccggacg ggcacaagga cgaactccac cacggcgcgg tcgtgatcgc cgccatcacg     1320

agctgcacca acacctccaa cccgtccgtg atgattggcg cggggctgtt ggcgaagaag     1380

gccgtggaga aggggctgaa gacgccgcgc tacgtgaaga cgtcgctcgc gccgggatcg     1440

cgcgtcgtca cggattacct ggagcgctcg ggcctgctcg agccactctc caagctcggc     1500

tttgacgtgg tcggctacgg ctgtaccacg tgcatcggaa acagcggccc gctgccggag     1560

gaagtggcca aggcgattca ggagaacgac ctcctggtct ccgcggtgtt gtcgggcaac     1620

cgcaacttcg aggggcgcat ccactcgctc gttcgcgcca actatctcgc ttcgccgccg     1680

ctcgtcgtgg cgtacgctat cgcgggcacg gtggacatcg atctcgtcaa cgagcccatc     1740

ggcaaggacg agaacggcaa cgacgtgttc ctgagggaca tctggccgtc gaacgaggag     1800

attcaggcgg tcatccggca aatcatccaa ccggagatgt tcaagaagga atacgagagc     1860

gtgttcaacc ggaacgagcg gtggaacaag ctggacgtcc cgaagggcga gctgtacgaa     1920

tgggatccga attcgacgta catccaggag ccgccgttct tcgaggggct gtcggaagag     1980

gttccggaca tccaggagat ccaaggcgcg cgcgtgctcg cgtacctggg cgactcggtg     2040

acgacggacc acatctcgcc cgcgggcagc atcgcgccgt cgagcccggc tggccagtac     2100

ctgcagtcca agggcgtgaa gccgcatgag ttcaactcgt acggttcgcg ccgcggcaac     2160

cacgaggtca tgatgcgcgg cacgttcgcg aacatccgca ttcgcaacaa ggtggcgcct     2220

ggcacggagg gcggttacac gacgtacttc ccgacgggcg aagtgatgcc gatttacgac     2280

gcggcgatga agtacaaggc ggatggcacg ccgctcgtgg tcatcgccgg caaggagtac     2340

ggaacaggct cgtcccgcga ctgggcggcg aagggcacct acttgctcgg cgtgaaggcc     2400

gtgatcgcgg agagcttcga gcgcatccac cggagcaacc tggtcggcat gggcgtgctg     2460

ccgctcgagt tcatcgacgg gcaaaacgcg gagacgcttg gcctgaccgg ccgcgaggtg     2520

tacaccatca aggggctgtc gaacgacctg aagccgcgcc agacggtcac ggtcgaagtc     2580

acgcgcgaag acggatcgtc gttcacgttc caagcgctcg tgcggctcga cagcgacatc     2640

gaggtggatt actaccgcaa cggcggtatc ctgcagacag tgctccgcaa cttcatgcgc     2700

gagcaacacg cgtaa                                                      2715


<210>   969
<211>   2715
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 954

<400>   969
gtgggcgcca atctgtttca agccaaacag accctcaccg ttggcgggaa gtcctatacc       60

tactaccgcc tggacgctct tcaggagcaa ggcgtagccg acatctcccg cctccccatt      120

tccatcaaaa ttctgcttga atccgtgctt cgccagtacg atggccgcgt catcacggag      180

gagcacgtgc gcgaactcgc caactggaac gcggcgaacc cggcgaaatc cgaggtccct      240

tttaagcccg cgcgcatcct gctgcaggat ttcacgggcg tgcctgtcgt ggtggatctg      300

gccgccatgc gcacggcgat gcacaagctc ggcggcaatc cgaagcggat caacccgctc      360

atcccggtcg atctcgtcat cgaccactcg gtgcaggtgg acgcgttcgg ttccaaagag      420

gcgctggagt tcaacatcgc gaaggaattc gagcgcaacg aggagcgcta ccgcttcctc      480

cgctgggcac aaacggcgtt cgacaacttc cgcgcggtgc cacccggaat gggcatcgtc      540

caccaggtca acctggagta cctcgcgcgc gtggtccagg agcggaccgt cgacggcgag      600

caagtcgtct tcccggatag cctcgtcggc accgactcgc acacgaccat gatcaacggc      660

gtcggcgtcc tcggctgggg cgtgggcggc atcgaggccg aggcgtgcat gctcggtcag      720

cccttgtact tcattcagcc cgaggtcatc ggcttcaagc tgaccggcaa actgcccgag      780

ggcgcgaccg cgaccgatct cgccctgact gtcgtgaaca tgctgcgcaa gaagggcgtc      840

gtcggcaagt tcgtcgagtt ctacggcgcc ggcctctcca acatcagcgt cgctgaccgc      900

gcgaccatcg ccaacatggc gcccgagtac ggtgcgacga tgggcttctt ccccatcgac      960

caggcgacgc tcgactatct ccgcctgacc ggccgcgacg aatcgctcat ccagctcgtc     1020

gaggcgtacg cgaaggcaca gggtatgttc cgcacggacg acatgccgga tcccgtcttc     1080

accgacacgc tggagctcga tctcggctcc atccagccga cgatggcggg tccgaagcgg     1140

ccgcaggata agatcttcct ctccgatatg aagaacaact tcgaggcggc gctcgagaag     1200

ccggtgtcgg agggcggttt cgggcttgcg gaccagcggg ataagacggc ccttgtccaa     1260

tatccggacg ggcacaagga cgaactccac cacggcgcgg tcgtgatcgc cgccatcacg     1320

agctgcacca acacctccaa cccgtccgtg atgattggcg cggggctgtt ggcgaagaag     1380

gccgtggaga aggggctgaa gacgccgcgc tacgtgaaga cgtcgctcgc gccgggatcg     1440

cgcgtcgtca cggattacct ggagcgctcg ggcctgctcg agccactctc caagctcggc     1500

tttgacgtgg tcggctacgg ctgtaccacg tgcatcggaa acagcggccc gctgccggag     1560

gaagtggcca aggcgattca ggagaacgac ctcctggtct ccgcggtgtt gtcgggcaac     1620

cgcaacttcg aggggcgcat ccactcgctc gttcgcgcca actatctcgc ttcgccgccg     1680

ctcgtcgtgg cgtacgctat cgcgggcacg gtggacatcg atctcgtcaa cgagcccatc     1740

ggcaaggacg agaacggcaa cgacgtgttc ctgagggaca tctggccgtc gaacgaggag     1800

attcaggcgg tcatccggca aatcatcaat ccggagatgt tcaagaagga atacgagagc     1860

gtgttcaacc ggaacgagcg gtggaacaag ctggacgtcc cgaagggcga gctgtacgaa     1920

tgggatccga attcgacgta catccaggag ccgccgttct tcgaggggct gtcggaagag     1980

gttccggaca tccaggagat ccaaggcgcg cgcgtgctcg cgtacctggg cgactcggtg     2040

acgacggacc acatctcgcc cgcgggcagc atcgcgccgt cgagcccggc tggccagtac     2100

ctgcagtcca agggcgtgaa gccgcatgag ttcaactcgt acggttcgcg ccgcggcaac     2160

cacgaggtca tgatgcgcgg cacgttcgcg aacatccgca ttcgcaacaa ggtggcgcct     2220

ggcacggagg gcggttacac gacgtacttc ccgacgggcg aagtgatgcc gatttacgac     2280

gcggcgatga agtacaaggc ggatggcacg ccgctcgtgg tcatcgccgg caaggagtac     2340

ggaacaggct cgtcccgcga ctgggcggcg aagggcacct acttgctcgg cgtgaaggcc     2400

gtgatcgcgg agagcttcga gcgcatccac cggagcaacc tggtcggcat gggcgtgctg     2460

ccgctcgagt tcatcgacgg gcaaaacgcg gagacgcttg gcctgaccgg ccgcgaggtg     2520

tacaccatca aggggctgtc gaacgacctg aagccgcgcc agacggtcac ggtcgaagtc     2580

acgcgcgaag acggatcgtc gttcacgttc caagcgctcg tgcggctcga cagcgacatc     2640

gaggtggatt actaccgcaa cggcggtatc ctgcagacag tgctccgcaa cttcatgcgc     2700

gagcaacacg cgtaa                                                      2715


<210>   970
<211>   351
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   970
Met Lys Ala Ala Arg Leu His Ala Phe His Thr Pro Phe Ala Ile Glu 
                5                   10                  15      

Thr Val Pro Asp Pro Glu Pro Gly Pro Glu Asp Ala Ile Val Arg Val 
            20                  25                  30          

Arg Ala Ala Gly Val Cys Arg Ser Asp Leu His Ile Trp Gln Gly Glu 
        35                  40                  45              

Leu Ala Trp Val Gly Ile Arg Pro Gln Leu Pro Ile Thr Leu Gly His 
    50                  55                  60                  

Glu Phe Gly Gly Glu Val Val Ala Val Gly Arg Asn Val Arg Arg Phe 
65                  70                  75                  80  

Val Ala Gly Asp Arg Val Thr Val Pro Phe His Asn Gly Cys Gly Arg 
                85                  90                  95      

Cys Pro Gln Cys Gln Ser Gly Arg Ser Asn Leu Cys Asp Glu Phe Gly 
            100                 105                 110         

Phe Tyr Gly Ala Thr Tyr Asp Gly Cys Phe Ala Glu Tyr Val Arg Val 
        115                 120                 125             

Pro Asn Ala Asp Phe Asn Leu Ile His Leu Pro Asp Glu Val Asp Phe 
    130                 135                 140                 

Val Thr Ala Ala Ala Met Gly Cys Arg Tyr Met Thr Gly Phe His Ala 
145                 150                 155                 160 

Val Met Arg Gly Arg Val Gln Pro Gly Glu Trp Val Ala Val His Gly 
                165                 170                 175     

Ala Gly Gly Val Gly Leu Ser Ala Ile Gln Ala Ala His Ala Ile Gly 
            180                 185                 190         

Ala Gln Val Ile Ala Val Asp Ile Asp Asp Asp Lys Leu Glu Lys Ala 
        195                 200                 205             

Arg Thr Glu Gly Ala Ala Val Thr Ile Asn Ser Arg Arg Glu Glu Arg 
    210                 215                 220                 

Val Phe Lys Ala Ile Lys Gln Val Thr Arg Gly Gly Ala His Val Ser 
225                 230                 235                 240 

Ile Asp Ala Leu Gly Leu Ala Glu Thr Val Phe Asn Ser Val Arg Cys 
                245                 250                 255     

Leu Arg Lys Gly Gly Arg His Val Gln Val Gly Leu Thr Ser Ser Ser 
            260                 265                 270         

Glu Gln Gly Met Val Ala Leu Pro Val Asp Ile Met Thr Thr Gly Glu 
        275                 280                 285             

Ile Glu Phe Ile Gly Ser Phe Gly Asn Pro His Val Ala Phe Asp Gly 
    290                 295                 300                 

Leu Leu Arg Leu Val Ala Ala Gly Arg Leu Arg Pro Lys Ala Leu Val 
305                 310                 315                 320 

Glu Arg Glu Val Ser Leu Ala Glu Leu Asn Asp Val Phe His Arg Met 
                325                 330                 335     

Leu Arg Phe Glu Thr Lys Gly Phe Asn Val Ile Thr Ala Phe Ala 
            340                 345                 350     

<210>   971
<211>   1056
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   971
gtgaaagctg cgcgcctgca cgcattccac acgccctttg ccatcgagac cgtcccagat       60

cccgaacctg gcccggagga cgccatcgtc cgcgtgcgtg cggccggcgt gtgccggagc      120

gatcttcaca tctggcaggg ggagctcgct tgggtcggga ttcggccgca gttgcccatc      180

accctgggcc acgaattcgg cggcgaggtg gtggcggtgg ggcgcaatgt ccgccgcttt      240

gtggcgggcg atcgcgtcac cgtcccgttc cacaacggct gcggccgatg cccgcagtgc      300

cagtcgggca ggtcgaatct ttgcgacgag ttcggattct acggcgccac gtatgacggg      360

tgcttcgccg aatacgtgcg tgtccccaac gccgacttca acctcatcca tttgcccgac      420

gaggtcgatt tcgtcacggc ggccgccatg gggtgccgct acatgacggg ctttcatgct      480

gtgatgcggg ggcgcgtcca gcccggtgaa tgggtggccg tgcacggcgc gggcggcgtc      540

gggctgtccg cgattcaggc ggcccacgcc atcggcgctc aggtgattgc cgtggacatc      600

gacgacgaca agctggagaa ggcgcggacc gaaggcgccg cggtgaccat caacagccgg      660

cgcgaggaac gcgtgttcaa ggccatcaag caggtcacgc gcggaggcgc gcacgtgagc      720

atcgacgcgc tcgggctcgc cgagacggtg ttcaactcgg tgcggtgcct gcgcaaaggc      780

gggcgccatg tacaggtcgg cctcacctcc tcgtccgagc agggcatggt ggcgctgccg      840

gtcgacatca tgaccacggg cgagatcgag ttcatcggaa gctttggcaa cccgcacgtc      900

gccttcgacg gcttgttgcg gttggtcgcc gcagggaggc tccggcccaa ggcgctcgtg      960

gagcgcgagg tgagcctcgc cgagttgaac gacgtgttcc atcgcatgct gcgcttcgag     1020

acgaaggggt tcaacgtgat cacggcgttc gcgtga                               1056


<210>   972
<211>   351
<212>   PRT
<213>   Streptomyces refuineus subsp. thermotolerans

<400>   972
Val Arg Ala Ala Gln Ile Val Gly Tyr Gly Glu Pro Leu Gln Val Arg 
                5                   10                  15      

Glu Val Pro Asp Pro Ala Pro Glu Pro Gly Gly Val Val Val Ala Val 
            20                  25                  30          

Leu Ala Thr Gly Ile Cys Arg Ser Asp Trp His Gly Trp Arg Gly Asp 
        35                  40                  45              

Trp Glu Trp Leu Gly Gly Arg Ile Ala Leu Pro Arg Thr Pro Gly His 
    50                  55                  60                  

Glu Ile Ala Gly Glu Val Val Ala Ala Gly Pro Gly Val Arg Gly Val 
65                  70                  75                  80  

Arg Val Gly Asp Arg Val Thr Val Pro Phe His Leu Ala Cys Gly Thr 
                85                  90                  95      

Cys Ala His Cys Arg Ala Gly Gln Ala Asn Leu Cys Asp Glu Met Glu 
            100                 105                 110         

Val Leu Gly Phe Trp Arg Asp Gly Gly Tyr Ala Glu Tyr Val Arg Ile 
        115                 120                 125             

Pro His Ala Asp Phe Asn Cys Val Arg Ile Pro Asp Gly Val Thr Pro 
    130                 135                 140                 

Leu Thr Ala Ser Ala Ile Gly Cys Arg Phe Met Thr Ala Phe His Ala 
145                 150                 155                 160 

Val Asp Gly Gln Gly Arg Val Arg Pro Gly Glu Trp Val Ala Val His 
                165                 170                 175     

Gly Val Gly Gly Val Gly Leu Ser Cys Val Gln Ile Ala Ser Ala Ala 
            180                 185                 190         

Gly Ala Ser Val Val Ala Val Asp Ile Asp Pro Ala Lys Leu Ala Leu 
        195                 200                 205             

Ala Glu Gln Gln Gly Ala Ala His Thr Val Asp Ala Gly Ala Glu Gln 
    210                 215                 220                 

Asp Val Pro Ala Ala Val Arg Glu Val Thr Gly Gly Gly Ala His Val 
225                 230                 235                 240 

Ser Ile Asp Ala Leu Gly Ile Arg Thr Thr Val Val Asn Ser Val Arg 
                245                 250                 255     

Ser Leu Arg Lys Arg Gly Arg His Val Gln Val Gly Leu Thr Gly Ala 
            260                 265                 270         

Glu Asp Ala Gly Glu Ile Ala Leu Pro Ile Asp Leu Ile Thr Leu Gly 
        275                 280                 285             

Glu Leu Thr Val Val Gly Ser His Gly Asn Pro His Ala Ala Tyr Pro 
    290                 295                 300                 

Arg Leu Leu Ser Leu Ile Glu Ser Gly Arg Leu Ala Pro Gln Thr Leu 
305                 310                 315                 320 

Val Gln Arg Thr Val Ser Leu Asp Gln Ala Gly Asp Val Leu Ala Ala 
                325                 330                 335     

Met Asp Ala Phe Ala Thr Ser Gly Leu Thr Val Ile Asp Arg Phe 
            340                 345                 350     

<210>   973
<211>   355
<212>   PRT
<213>   Halorubrum lacusprofundi ATCC 49239

<400>   973
Met Arg Ala Ala Ile Leu Arg Glu Tyr Gly Glu Pro Leu Asp Ile His 
                5                   10                  15      

Glu Val Pro Asp Pro Glu Pro Gly Pro Asp Gly Ala Val Val Arg Val 
            20                  25                  30          

Thr Ala Cys Gly Val Cys Arg Ser Asp Trp His Ala Trp Ala Gly His 
        35                  40                  45              

Gly Glu Trp Ala Asp Asp Arg Val Pro Arg Gly Gln Val Leu Gly His 
    50                  55                  60                  

Glu Pro Ala Gly Glu Val Val Thr Val Gly Asp Ser Val Asp Arg Phe 
65                  70                  75                  80  

Ala Pro Gly Asp Arg Val Val Val Pro Phe Ser Leu Gly Asp Gly Thr 
                85                  90                  95      

Cys Pro Arg Cys Arg Gln Gly His Gly Asn Val Cys Asp Asp Gly Arg 
            100                 105                 110         

Ala Leu Gly Phe Glu Pro Glu Ala Pro Gly Ala Phe Ala Glu Arg Val 
        115                 120                 125             

Ala Val Pro Asp Ala Asp Tyr Asn Leu Val Glu Arg Pro Pro Trp Leu 
    130                 135                 140                 

Asp Ala Thr Ala Ala Ala Ala Leu Gly Cys Arg Tyr Met Thr Ala Tyr 
145                 150                 155                 160 

His Ala Leu Ala Glu Arg Ala Gly Leu Asp Gly Gly Glu Trp Leu Ala 
                165                 170                 175     

Val His Gly Cys Gly Gly Val Gly Leu Ser Ala Val Gln Leu Gly Asp 
            180                 185                 190         

Ala Leu Gly Ala Arg Ile Val Ala Val Asp Val Asp Asp Asp Ala Leu 
        195                 200                 205             

Ser Leu Ala Arg Asp Leu Gly Ala Asp Glu Thr Val Asn Pro Asn Asp 
    210                 215                 220                 

Leu Asp Glu Glu Thr Val Pro Asp Arg Val Arg Asn Leu Thr Asp Gly 
225                 230                 235                 240 

Gly Ala Asp Val Ser Val Asp Ala Leu Gly Ile Ala Glu Thr Cys Arg 
                245                 250                 255     

Asn Ser Val Arg Ser Val Arg Pro Arg Gly Thr His Val Gln Val Gly 
            260                 265                 270         

Leu Thr Thr Glu Ala Glu Arg Gly Glu Val Ser Leu Pro Thr Asp Trp 
        275                 280                 285             

Met Thr Arg Trp Glu Val Ser Phe Val Gly Ser Arg Gly Met Pro Pro 
    290                 295                 300                 

Thr Ser Tyr Asp Asp Leu Phe Ala Leu Val Glu Ala Thr Asp Val Asp 
305                 310                 315                 320 

Pro Ala Ala Leu Val Ser Glu Glu Leu Ala Leu Ser Glu Val Ser Glu 
                325                 330                 335     

Arg Leu Ala Ala Met Gly Glu Tyr Asp Ala Arg Gly Val Glu Val Val 
            340                 345                 350         

Thr Asp Phe 
        355 

<210>   974
<211>   349
<212>   PRT
<213>   Propionibacterium acnes KPA171202

<400>   974
Met Lys Ala Ala Leu Val Glu Gln Tyr His Glu Pro Leu Ala Ile Arg 
                5                   10                  15      

Asp Ile Pro Glu Pro Ala His Asp Ser Asp Gly Val Val Val Glu Val 
            20                  25                  30          

Lys Ala Cys Gly Val Cys Arg Ser Asp Trp His Gly Trp Gln Gly Glu 
        35                  40                  45              

Trp Pro Gly Phe Thr Gly Gly Ser Leu Pro His Ile Phe Gly His Glu 
    50                  55                  60                  

Phe Val Gly Leu Val Ser Asp Ile Gly Asn Asn Val Ser Arg Tyr Arg 
65                  70                  75                  80  

Val Gly Asp Arg Val Ile Val Pro Phe Thr Leu Gly Cys Gly His Cys 
                85                  90                  95      

Glu Tyr Cys Arg Ser Gly His Ser Asn Val Cys Pro Thr Val Ser Met 
            100                 105                 110         

Pro Gly Phe Ser Tyr Asp Gly Gly Phe Ala Gln Tyr Val Thr Val Pro 
        115                 120                 125             

Asp Ala Asp Ala Asn Leu Val Lys Leu Pro Asp Ala Val Asp Phe Thr 
    130                 135                 140                 

Asp Ala Ala Gly Met Gly Cys Arg Leu Met Thr Ala Tyr His Gly Ile 
145                 150                 155                 160 

Val Glu Val Gly Gln Ile His Pro Gly Asp Trp Leu Val Val Tyr Gly 
                165                 170                 175     

Ala Gly Gly Val Gly Leu Ser Ala Thr Leu Val Ala Thr Ser Ala Gly 
            180                 185                 190         

Ala Asn Val Ile Ala Val Asp Ile Ala Asp Asp Lys Leu Ala Leu Ala 
        195                 200                 205             

Arg Lys Val Gly Ala Ile Ala Thr Ile Asn Ser Arg Glu Thr Asp Pro 
    210                 215                 220                 

Val Glu Ala Val Arg Glu Leu Thr Asp Gly Gly Ala Asp Lys Ser Val 
225                 230                 235                 240 

Asp Ala Leu Gly Ile Ser Glu Thr Leu His Asn Ala Val Asn Ser Leu 
                245                 250                 255     

Arg Ser Arg Gly Thr His Ile Gln Ile Gly Met Thr Ala Glu Gly Pro 
            260                 265                 270         

Val Gly Asp Val Ala Leu Thr Ile Asn Asp Leu Ile Ala Lys Glu Ile 
        275                 280                 285             

Asp Phe Arg Gly Ser Phe Gly Met Pro Ala Val Glu Phe Arg Tyr Leu 
    290                 295                 300                 

Leu Asn Gln Val Ala Ala Gly Lys Met Lys Pro Gly Gln Leu Val Thr 
305                 310                 315                 320 

Lys Thr Ile Ala Leu Ser Glu Val Asn Asp Ala Leu Thr Ala Met Ser 
                325                 330                 335     

Thr Tyr Asn Thr Val Gly Thr Thr Val Ile Thr Asp Phe 
            340                 345                 

<210>   975
<211>   353
<212>   PRT
<213>   Haloarcula marismortui ATCC 43049

<400>   975
Met Arg Ala Ala Val Ile Glu Glu His Gly Glu Pro Leu Thr Ile Gln 
                5                   10                  15      

Asp Val Pro Tyr Pro Glu Pro Gln Pro Asp Gln Val Val Ile Glu Thr 
            20                  25                  30          

Glu Ala Cys Gly Val Cys Arg Ser Asp Trp His Ala Trp Gln Gly Asp 
        35                  40                  45              

Trp Glu Trp Phe Gly Ile Gln Thr Gly Pro Gly Gln Ile Leu Gly His 
    50                  55                  60                  

Glu Pro Ala Gly Val Val Ala Asp Val Gly Ala Asp Val Glu Gln Phe 
65                  70                  75                  80  

Ser Glu Gly Asp Arg Val Thr Val Pro Phe His Leu Gly Asp Gly Ser 
                85                  90                  95      

Cys Gln Tyr Cys Gln Arg Gly His Ala Asn Ile Cys Glu Thr Ser Met 
            100                 105                 110         

Pro Leu Gly Phe Leu Glu Ala Ala Pro Gly Ala Phe Ala Glu Ala Phe 
        115                 120                 125             

Pro Val Arg Glu Ala Asp Phe Asn Cys Val Thr Leu Pro Asp Ala Val 
    130                 135                 140                 

Asp Phe Thr Glu Met Ala Gly Leu Gly Cys Arg Phe Met Thr Ala Tyr 
145                 150                 155                 160 

His Ala Leu Thr Asp Arg Ala Thr Leu Arg Pro Gly Asp Ala Val Ala 
                165                 170                 175     

Ile His Gly Cys Gly Gly Val Gly Leu Ser Ala Val His Ile Ala Asp 
            180                 185                 190         

Ala Leu Gly Ala Glu Pro Ile Ala Val Asp Val Gln Asp Arg Lys Leu 
        195                 200                 205             

Asp Arg Ala Arg Asp Leu Gly Ala Ala Ala Thr Ile Asn Ala Ala Glu 
    210                 215                 220                 

Ala Asp Asn Val Pro Gly Glu Val His Ala Val Thr Asp Gly Gly Ala 
225                 230                 235                 240 

Asp Val Ala Ile Asp Ala Leu Gly Ile Ala Glu Thr Cys Arg Asn Ala 
                245                 250                 255     

Val Gly Ser Leu Gly Lys Gln Gly Thr His Val Gln Val Gly Leu Thr 
            260                 265                 270         

Thr Asp Asp Glu Ala Gly Glu Ile Pro Leu Pro Val Asp Thr Met Thr 
        275                 280                 285             

Leu Gln Glu Ile Asp Phe His Gly Ser Tyr Gly Met Pro Pro Val Arg 
    290                 295                 300                 

Tyr Asp Glu Leu Phe Arg Leu Ile Asp Ala Gly Thr Leu Asp Pro Ser 
305                 310                 315                 320 

Gln Ile Val Gly Glu Thr Leu Ala Leu Glu Asp Val Pro Ala Thr Leu 
                325                 330                 335     

Ser Ser Met Gly Glu Tyr Glu Thr Val Gly Ile Pro Val Ile Asp Glu 
            340                 345                 350         

Phe 
    

<210>   976
<211>   346
<212>   PRT
<213>   Mesorhizobium loti MAFF303099

<400>   976
Met Lys Ala Val Val Phe Glu Lys Phe Gly Glu Ala Pro Thr Ile Gln 
                5                   10                  15      

Thr Val Pro Asp Pro Lys Pro Ala Ala Asp Gly Val Val Ile Lys Val 
            20                  25                  30          

Glu Ala Thr Gly Leu Cys Arg Ser Asp Trp His Gly Trp Met Gly His 
        35                  40                  45              

Asp Asp Gly Ile Thr Leu Pro His Val Pro Gly His Glu Leu Ala Gly 
    50                  55                  60                  

Val Val Val Ala Ala Gly Lys Gln Val Ser Arg Trp Lys Ala Gly Asp 
65                  70                  75                  80  

Arg Val Thr Val Pro Phe Ala Val Gly Cys Gly Arg Cys Phe Glu Cys 
                85                  90                  95      

Ser Ser Gly Asn His Gln Val Cys Glu His Gln Thr Gln Pro Gly Phe 
            100                 105                 110         

Thr Gly Trp Gly Ser Phe Ala Glu Tyr Val Gly Ile Glu His Ala Asp 
        115                 120                 125             

Thr Asn Leu Val Arg Leu Pro Asp Glu Met Glu Tyr Ala Thr Ala Ala 
    130                 135                 140                 

Ser Leu Gly Cys Arg Phe Val Thr Ser Phe Arg Ala Ile Val Asp Gln 
145                 150                 155                 160 

Gly Arg Val Lys Pro Gly Glu Trp Val Ala Val His Gly Cys Gly Gly 
                165                 170                 175     

Val Gly Leu Ser Ala Ile Met Ile Ala Ser Ser Met Gly Ala Asn Val 
            180                 185                 190         

Ile Ala Ile Asp Leu Thr Asp Glu Lys Leu Glu Phe Ala Arg Lys Ile 
        195                 200                 205             

Gly Ala Val Ala Thr Ile Asn Ala Ser Thr Thr Pro Asn Val Val Lys 
    210                 215                 220                 

Ala Val Lys Gln Ile Ala Asn Gly Gly Ala His Met Ser Met Asp Ala 
225                 230                 235                 240 

Leu Gly His Pro Thr Thr Ser Phe Asn Ser Ile Ala Asn Leu Arg Arg 
                245                 250                 255     

Arg Gly Arg His Val Gln Val Gly Leu Met Leu Gly Glu His Ala Arg 
            260                 265                 270         

Pro Gln Val Pro Met Asp Lys Ile Ile Ala Phe Glu Leu Glu Ile Leu 
        275                 280                 285             

Gly Ser His Gly Met Gln Ala Tyr Arg Tyr Gln Ala Met Met Asp Met 
    290                 295                 300                 

Ile Arg Asn Gly Lys Leu Lys Pro Glu Leu Leu Val Gly Lys Lys Ile 
305                 310                 315                 320 

Ser Leu Asp Glu Ala Pro Ala Ala Leu Met Ala Met Gly Gly Phe Glu 
                325                 330                 335     

Gly Ile Gly Ile Gly Val Val Thr Lys Phe 
            340                 345     

<210>   977
<211>   351
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 970

<400>   977
Met Lys Ala Ala Arg Leu His Ala Phe His Thr Pro Phe Ala Ile Glu 
                5                   10                  15      

Thr Val Pro Asp Pro Glu Pro Gly Pro Glu Asp Ala Ile Val Arg Val 
            20                  25                  30          

Arg Ala Ala Gly Val Cys Arg Ser Asp Leu His Ile Trp Gln Gly Glu 
        35                  40                  45              

Leu Ala Trp Val Gly Ile Arg Pro Gln Leu Pro Ile Thr Leu Gly His 
    50                  55                  60                  

Glu Phe Gly Gly Glu Val Ile Ala Val Gly Arg Asn Val Arg Arg Phe 
65                  70                  75                  80  

Val Ala Gly Asp Arg Val Thr Val Pro Phe His Asn Gly Cys Gly Arg 
                85                  90                  95      

Cys Pro Gln Cys Gln Ser Gly Arg Ser Asn Leu Cys Asp Glu Phe Gly 
            100                 105                 110         

Phe Tyr Gly Ala Thr Tyr Asp Gly Cys Phe Ala Glu Tyr Val Arg Val 
        115                 120                 125             

Pro Asn Ala Asp Phe Asn Leu Ile His Leu Pro Asp Glu Val Asp Phe 
    130                 135                 140                 

Val Thr Ala Ala Ala Met Gly Cys Arg Tyr Met Thr Gly Phe His Ala 
145                 150                 155                 160 

Val Met Arg Gly Arg Val Gln Pro Gly Glu Trp Val Ala Val His Gly 
                165                 170                 175     

Ala Gly Gly Val Gly Leu Ser Ala Ile Gln Ala Ala His Ala Ile Gly 
            180                 185                 190         

Ala Gln Val Ile Ala Val Asp Ile Asp Asp Asp Lys Leu Glu Lys Ala 
        195                 200                 205             

Arg Thr Glu Gly Ala Ala Val Thr Ile Asn Ser Arg Arg Glu Glu Arg 
    210                 215                 220                 

Val Phe Lys Ala Ile Lys Gln Val Thr Arg Gly Gly Ala His Val Ser 
225                 230                 235                 240 

Ile Asp Ala Leu Gly Leu Ala Glu Thr Val Phe Asn Ser Val Arg Cys 
                245                 250                 255     

Leu Arg Lys Gly Gly Arg His Val Gln Val Gly Leu Thr Ser Ser Ser 
            260                 265                 270         

Glu Gln Gly Met Val Ala Leu Pro Val Asp Ile Met Thr Thr Gly Glu 
        275                 280                 285             

Ile Glu Phe Ile Gly Ser Phe Gly Asn Pro His Val Ala Phe Asp Gly 
    290                 295                 300                 

Leu Leu Arg Leu Val Ala Ala Gly Arg Leu Arg Pro Lys Ala Leu Val 
305                 310                 315                 320 

Glu Arg Glu Val Ser Leu Ala Glu Leu Asn Asp Val Phe His Arg Met 
                325                 330                 335     

Leu Arg Phe Glu Thr Lys Gly Phe Asn Val Ile Thr Ala Phe Ala 
            340                 345                 350     

<210>   978
<211>   351
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 970

<400>   978
Met Lys Ala Ala Arg Leu His Ala Phe His Thr Pro Phe Ala Ile Glu 
                5                   10                  15      

Thr Val Pro Asp Pro Glu Pro Gly Pro Glu Asp Ala Ile Val Arg Val 
            20                  25                  30          

Arg Ala Ala Gly Val Cys Arg Ser Asp Leu His Ile Trp Gln Gly Glu 
        35                  40                  45              

Leu Ala Trp Val Gly Ile Lys Pro Gln Leu Pro Ile Thr Leu Gly His 
    50                  55                  60                  

Glu Phe Gly Gly Glu Val Val Ala Val Gly Arg Asn Val Arg Arg Phe 
65                  70                  75                  80  

Val Ala Gly Asp Arg Val Thr Val Pro Phe His Asn Gly Cys Gly Arg 
                85                  90                  95      

Cys Pro Gln Cys Gln Ser Gly Arg Ser Asn Leu Cys Asp Glu Phe Gly 
            100                 105                 110         

Phe Tyr Gly Ala Thr Tyr Asp Gly Cys Phe Ala Glu Tyr Val Arg Val 
        115                 120                 125             

Pro Asn Ala Asp Phe Asn Leu Ile His Leu Pro Asp Glu Val Asp Phe 
    130                 135                 140                 

Val Thr Ala Ala Ala Met Gly Cys Arg Tyr Met Thr Gly Phe His Ala 
145                 150                 155                 160 

Val Met Arg Gly Arg Val Gln Pro Gly Glu Trp Val Ala Val His Gly 
                165                 170                 175     

Ala Gly Gly Val Gly Leu Ser Ala Ile Gln Ala Ala His Ala Ile Gly 
            180                 185                 190         

Ala Gln Val Ile Ala Val Asp Ile Asp Asp Asp Lys Leu Glu Lys Ala 
        195                 200                 205             

Arg Thr Glu Gly Ala Ala Val Thr Ile Asn Ser Arg Arg Glu Glu Arg 
    210                 215                 220                 

Val Phe Lys Ala Ile Lys Gln Val Thr Arg Gly Gly Ala His Val Ser 
225                 230                 235                 240 

Ile Asp Ala Leu Gly Leu Ala Glu Thr Val Phe Asn Ser Val Arg Cys 
                245                 250                 255     

Leu Arg Lys Gly Gly Arg His Val Gln Val Gly Leu Thr Ser Ser Ser 
            260                 265                 270         

Glu Gln Gly Met Val Ala Leu Pro Val Asp Ile Met Thr Thr Gly Glu 
        275                 280                 285             

Ile Glu Phe Ile Gly Ser Phe Gly Asn Pro His Val Ala Phe Asp Gly 
    290                 295                 300                 

Leu Leu Arg Leu Val Ala Ala Gly Arg Leu Arg Pro Lys Ala Leu Val 
305                 310                 315                 320 

Glu Arg Glu Val Ser Leu Ala Glu Leu Asn Asp Val Phe His Arg Met 
                325                 330                 335     

Leu Arg Phe Glu Thr Lys Gly Phe Asn Val Ile Thr Ala Phe Ala 
            340                 345                 350     

<210>   979
<211>   351
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 970

<400>   979
Met Lys Ala Ala Arg Leu His Ala Phe His Thr Pro Phe Ala Ile Glu 
                5                   10                  15      

Thr Val Pro Asp Pro Glu Pro Gly Pro Glu Asp Ala Ile Val Arg Val 
            20                  25                  30          

Arg Ala Ala Gly Val Cys Arg Ser Asp Leu His Ile Trp Gln Gly Glu 
        35                  40                  45              

Leu Ala Trp Val Gly Ile Arg Pro Gln Leu Pro Ile Thr Leu Gly His 
    50                  55                  60                  

Glu Phe Gly Gly Glu Val Val Ala Val Gly Arg Asn Val Arg Arg Phe 
65                  70                  75                  80  

Val Ala Gly Asp Arg Val Thr Val Pro Phe His Asn Gly Cys Gly Arg 
                85                  90                  95      

Cys Pro Gln Cys Gln Ser Gly Arg Ser Asn Leu Cys Asp Glu Phe Gly 
            100                 105                 110         

Phe Tyr Gly Ala Thr Tyr Asp Gly Cys Phe Ala Glu Tyr Val Arg Val 
        115                 120                 125             

Pro Asn Ala Asp Phe Asn Leu Ile His Leu Pro Asp Glu Val Asp Phe 
    130                 135                 140                 

Val Thr Ala Ala Ala Met Gly Cys Arg Tyr Met Thr Gly Phe His Ala 
145                 150                 155                 160 

Val Met Arg Gly Arg Val Gln Pro Gly Glu Trp Val Ala Val His Gly 
                165                 170                 175     

Ala Gly Gly Val Gly Leu Ser Ala Ile Gln Ala Ala His Ala Ile Gly 
            180                 185                 190         

Ala Gln Val Ile Ala Val Asp Ile Asp Asp Asp Lys Leu Glu Lys Ala 
        195                 200                 205             

Arg Thr Glu Gly Ala Ala Val Thr Ile Asn Ser Arg Arg Glu Glu Arg 
    210                 215                 220                 

Val Phe Lys Ala Ile Lys Gln Val Thr Arg Gly Gly Ala His Val Ser 
225                 230                 235                 240 

Ile Asp Ala Leu Gly Leu Ala Glu Thr Val Phe Asn Ser Val Arg Cys 
                245                 250                 255     

Leu Lys Lys Gly Gly Arg His Val Gln Val Gly Leu Thr Ser Ser Ser 
            260                 265                 270         

Glu Gln Gly Met Val Ala Leu Pro Val Asp Ile Met Thr Thr Gly Glu 
        275                 280                 285             

Ile Glu Phe Ile Gly Ser Phe Gly Asn Pro His Val Ala Phe Asp Gly 
    290                 295                 300                 

Leu Leu Arg Leu Val Ala Ala Gly Arg Leu Arg Pro Lys Ala Leu Val 
305                 310                 315                 320 

Glu Arg Glu Val Ser Leu Ala Glu Leu Asn Asp Val Phe His Arg Met 
                325                 330                 335     

Leu Arg Phe Glu Thr Lys Gly Phe Asn Val Ile Thr Ala Phe Ala 
            340                 345                 350     

<210>   980
<211>   351
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 970

<400>   980
Met Lys Ala Ala Arg Leu His Ala Phe His Thr Pro Phe Ala Ile Glu 
                5                   10                  15      

Thr Val Pro Asp Pro Glu Pro Gly Pro Glu Asp Ala Ile Val Arg Val 
            20                  25                  30          

Arg Ala Ala Gly Val Cys Arg Ser Asp Leu His Ile Trp Gln Gly Glu 
        35                  40                  45              

Leu Ala Trp Val Gly Ile Arg Pro Gln Leu Pro Ile Thr Leu Gly His 
    50                  55                  60                  

Glu Phe Gly Gly Glu Val Val Ala Val Gly Arg Asn Val Arg Arg Phe 
65                  70                  75                  80  

Val Ala Gly Asp Arg Val Thr Val Pro Phe His Asn Gly Cys Gly Arg 
                85                  90                  95      

Cys Pro Gln Cys Gln Ser Gly Arg Ser Asn Leu Cys Asp Asp Phe Gly 
            100                 105                 110         

Phe Tyr Gly Ala Thr Tyr Asp Gly Cys Phe Ala Glu Tyr Val Arg Val 
        115                 120                 125             

Pro Asn Ala Asp Phe Asn Leu Ile His Leu Pro Asp Glu Val Asp Phe 
    130                 135                 140                 

Val Thr Ala Ala Ala Met Gly Cys Arg Tyr Met Thr Gly Phe His Ala 
145                 150                 155                 160 

Val Met Arg Gly Arg Val Gln Pro Gly Glu Trp Val Ala Val His Gly 
                165                 170                 175     

Ala Gly Gly Val Gly Leu Ser Ala Ile Gln Ala Ala His Ala Ile Gly 
            180                 185                 190         

Ala Gln Val Ile Ala Val Asp Ile Asp Asp Asp Lys Leu Glu Lys Ala 
        195                 200                 205             

Arg Thr Glu Gly Ala Ala Val Thr Ile Asn Ser Arg Arg Glu Glu Arg 
    210                 215                 220                 

Val Phe Lys Ala Ile Lys Gln Val Thr Arg Gly Gly Ala His Val Ser 
225                 230                 235                 240 

Ile Asp Ala Leu Gly Leu Ala Glu Thr Val Phe Asn Ser Val Arg Cys 
                245                 250                 255     

Leu Arg Lys Gly Gly Arg His Val Gln Val Gly Leu Thr Ser Ser Ser 
            260                 265                 270         

Glu Gln Gly Met Val Ala Leu Pro Val Asp Ile Met Thr Thr Gly Glu 
        275                 280                 285             

Ile Glu Phe Ile Gly Ser Phe Gly Asn Pro His Val Ala Phe Asp Gly 
    290                 295                 300                 

Leu Leu Arg Leu Val Ala Ala Gly Arg Leu Arg Pro Lys Ala Leu Val 
305                 310                 315                 320 

Glu Arg Glu Val Ser Leu Ala Glu Leu Asn Asp Val Phe His Arg Met 
                325                 330                 335     

Leu Arg Phe Glu Thr Lys Gly Phe Asn Val Ile Thr Ala Phe Ala 
            340                 345                 350     

<210>   981
<211>   351
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 970

<400>   981
Met Lys Ala Ala Arg Leu His Ala Phe His Thr Pro Phe Ala Ile Glu 
                5                   10                  15      

Thr Val Pro Asp Pro Glu Pro Gly Pro Glu Glu Ala Ile Val Arg Val 
            20                  25                  30          

Arg Ala Ala Gly Val Cys Arg Ser Asp Leu His Ile Trp Gln Gly Glu 
        35                  40                  45              

Leu Ala Trp Val Gly Ile Arg Pro Gln Leu Pro Ile Thr Leu Gly His 
    50                  55                  60                  

Glu Phe Gly Gly Glu Val Val Ala Val Gly Arg Asn Val Arg Arg Phe 
65                  70                  75                  80  

Val Ala Gly Asp Arg Val Thr Val Pro Phe His Asn Gly Cys Gly Arg 
                85                  90                  95      

Cys Pro Gln Cys Gln Ser Gly Arg Ser Asn Leu Cys Asp Glu Phe Gly 
            100                 105                 110         

Phe Tyr Gly Ala Thr Tyr Asp Gly Cys Phe Ala Glu Tyr Val Arg Val 
        115                 120                 125             

Pro Asn Ala Asp Phe Asn Leu Ile His Leu Pro Asp Glu Val Asp Phe 
    130                 135                 140                 

Val Thr Ala Ala Ala Met Gly Cys Arg Tyr Met Thr Gly Phe His Ala 
145                 150                 155                 160 

Val Met Arg Gly Arg Val Gln Pro Gly Glu Trp Val Ala Val His Gly 
                165                 170                 175     

Ala Gly Gly Val Gly Leu Ser Ala Ile Gln Ala Ala His Ala Ile Gly 
            180                 185                 190         

Ala Gln Val Ile Ala Val Asp Ile Asp Asp Asp Lys Leu Glu Lys Ala 
        195                 200                 205             

Arg Thr Glu Gly Ala Ala Val Thr Ile Asn Ser Arg Arg Glu Glu Arg 
    210                 215                 220                 

Val Phe Lys Ala Ile Lys Gln Val Thr Arg Gly Gly Ala His Val Ser 
225                 230                 235                 240 

Ile Asp Ala Leu Gly Leu Ala Glu Thr Val Phe Asn Ser Val Arg Cys 
                245                 250                 255     

Leu Arg Lys Gly Gly Arg His Val Gln Val Gly Leu Thr Ser Ser Ser 
            260                 265                 270         

Glu Gln Gly Met Val Ala Leu Pro Val Asp Ile Met Thr Thr Gly Glu 
        275                 280                 285             

Ile Glu Phe Ile Gly Ser Phe Gly Asn Pro His Val Ala Phe Asp Gly 
    290                 295                 300                 

Leu Leu Arg Leu Val Ala Ala Gly Arg Leu Arg Pro Lys Ala Leu Val 
305                 310                 315                 320 

Glu Arg Glu Val Ser Leu Ala Glu Leu Asn Asp Val Phe His Arg Met 
                325                 330                 335     

Leu Arg Phe Glu Thr Lys Gly Phe Asn Val Ile Thr Ala Phe Ala 
            340                 345                 350     

<210>   982
<211>   1056
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 971

<400>   982
gtgaaagctg cgcgcctgca cgcattccac acgccctttg ccatcgagac cgtcccagat       60

cccgaacctg gcccggagga cgccatcgtc cgcgtgcgtg cggccggcgt gtgccggagc      120

gatcttcaca tctggcaggg ggagctcgct tgggtcggga ttcggccgca gttgcccatc      180

accctgggcc acgaattcgg cggcgaggtg attgcggtgg ggcgcaatgt ccgccgcttt      240

gtggcgggcg atcgcgtcac cgtcccgttc cacaacggct gcggccgatg cccgcagtgc      300

cagtcgggca ggtcgaatct ttgcgacgag ttcggattct acggcgccac gtatgacggg      360

tgcttcgccg aatacgtgcg tgtccccaac gccgacttca acctcatcca tttgcccgac      420

gaggtcgatt tcgtcacggc ggccgccatg gggtgccgct acatgacggg ctttcatgct      480

gtgatgcggg ggcgcgtcca gcccggtgaa tgggtggccg tgcacggcgc gggcggcgtc      540

gggctgtccg cgattcaggc ggcccacgcc atcggcgctc aggtgattgc cgtggacatc      600

gacgacgaca agctggagaa ggcgcggacc gaaggcgccg cggtgaccat caacagccgg      660

cgcgaggaac gcgtgttcaa ggccatcaag caggtcacgc gcggaggcgc gcacgtgagc      720

atcgacgcgc tcgggctcgc cgagacggtg ttcaactcgg tgcggtgcct gcgcaaaggc      780

gggcgccatg tacaggtcgg cctcacctcc tcgtccgagc agggcatggt ggcgctgccg      840

gtcgacatca tgaccacggg cgagatcgag ttcatcggaa gctttggcaa cccgcacgtc      900

gccttcgacg gcttgttgcg gttggtcgcc gcagggaggc tccggcccaa ggcgctcgtg      960

gagcgcgagg tgagcctcgc cgagttgaac gacgtgttcc atcgcatgct gcgcttcgag     1020

acgaaggggt tcaacgtgat cacggcgttc gcgtga                               1056


<210>   983
<211>   1056
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 971

<400>   983
gtgaaagctg cgcgcctgca cgcattccac acgccctttg ccatcgagac cgtcccagat       60

cccgaacctg gcccggagga cgccatcgtc cgcgtgcgtg cggccggcgt gtgccggagc      120

gatcttcaca tctggcaggg ggagctcgct tgggtcggga ttaaaccgca gttgcccatc      180

accctgggcc acgaattcgg cggcgaggtg gtggcggtgg ggcgcaatgt ccgccgcttt      240

gtggcgggcg atcgcgtcac cgtcccgttc cacaacggct gcggccgatg cccgcagtgc      300

cagtcgggca ggtcgaatct ttgcgacgag ttcggattct acggcgccac gtatgacggg      360

tgcttcgccg aatacgtgcg tgtccccaac gccgacttca acctcatcca tttgcccgac      420

gaggtcgatt tcgtcacggc ggccgccatg gggtgccgct acatgacggg ctttcatgct      480

gtgatgcggg ggcgcgtcca gcccggtgaa tgggtggccg tgcacggcgc gggcggcgtc      540

gggctgtccg cgattcaggc ggcccacgcc atcggcgctc aggtgattgc cgtggacatc      600

gacgacgaca agctggagaa ggcgcggacc gaaggcgccg cggtgaccat caacagccgg      660

cgcgaggaac gcgtgttcaa ggccatcaag caggtcacgc gcggaggcgc gcacgtgagc      720

atcgacgcgc tcgggctcgc cgagacggtg ttcaactcgg tgcggtgcct gcgcaaaggc      780

gggcgccatg tacaggtcgg cctcacctcc tcgtccgagc agggcatggt ggcgctgccg      840

gtcgacatca tgaccacggg cgagatcgag ttcatcggaa gctttggcaa cccgcacgtc      900

gccttcgacg gcttgttgcg gttggtcgcc gcagggaggc tccggcccaa ggcgctcgtg      960

gagcgcgagg tgagcctcgc cgagttgaac gacgtgttcc atcgcatgct gcgcttcgag     1020

acgaaggggt tcaacgtgat cacggcgttc gcgtga                               1056


<210>   984
<211>   1056
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 971

<400>   984
gtgaaagctg cgcgcctgca cgcattccac acgccctttg ccatcgagac cgtcccagat       60

cccgaacctg gcccggagga cgccatcgtc cgcgtgcgtg cggccggcgt gtgccggagc      120

gatcttcaca tctggcaggg ggagctcgct tgggtcggga ttcggccgca gttgcccatc      180

accctgggcc acgaattcgg cggcgaggtg gtggcggtgg ggcgcaatgt ccgccgcttt      240

gtggcgggcg atcgcgtcac cgtcccgttc cacaacggct gcggccgatg cccgcagtgc      300

cagtcgggca ggtcgaatct ttgcgacgag ttcggattct acggcgccac gtatgacggg      360

tgcttcgccg aatacgtgcg tgtccccaac gccgacttca acctcatcca tttgcccgac      420

gaggtcgatt tcgtcacggc ggccgccatg gggtgccgct acatgacggg ctttcatgct      480

gtgatgcggg ggcgcgtcca gcccggtgaa tgggtggccg tgcacggcgc gggcggcgtc      540

gggctgtccg cgattcaggc ggcccacgcc atcggcgctc aggtgattgc cgtggacatc      600

gacgacgaca agctggagaa ggcgcggacc gaaggcgccg cggtgaccat caacagccgg      660

cgcgaggaac gcgtgttcaa ggccatcaag caggtcacgc gcggaggcgc gcacgtgagc      720

atcgacgcgc tcgggctcgc cgagacggtg ttcaactcgg tgcggtgcct gaaaaaaggc      780

gggcgccatg tacaggtcgg cctcacctcc tcgtccgagc agggcatggt ggcgctgccg      840

gtcgacatca tgaccacggg cgagatcgag ttcatcggaa gctttggcaa cccgcacgtc      900

gccttcgacg gcttgttgcg gttggtcgcc gcagggaggc tccggcccaa ggcgctcgtg      960

gagcgcgagg tgagcctcgc cgagttgaac gacgtgttcc atcgcatgct gcgcttcgag     1020

acgaaggggt tcaacgtgat cacggcgttc gcgtga                               1056


<210>   985
<211>   1056
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 971

<400>   985
gtgaaagctg cgcgcctgca cgcattccac acgccctttg ccatcgagac cgtcccagat       60

cccgaacctg gcccggagga cgccatcgtc cgcgtgcgtg cggccggcgt gtgccggagc      120

gatcttcaca tctggcaggg ggagctcgct tgggtcggga ttcggccgca gttgcccatc      180

accctgggcc acgaattcgg cggcgaggtg gtggcggtgg ggcgcaatgt ccgccgcttt      240

gtggcgggcg atcgcgtcac cgtcccgttc cacaacggct gcggccgatg cccgcagtgc      300

cagtcgggca ggtcgaatct ttgcgacgat ttcggattct acggcgccac gtatgacggg      360

tgcttcgccg aatacgtgcg tgtccccaac gccgacttca acctcatcca tttgcccgac      420

gaggtcgatt tcgtcacggc ggccgccatg gggtgccgct acatgacggg ctttcatgct      480

gtgatgcggg ggcgcgtcca gcccggtgaa tgggtggccg tgcacggcgc gggcggcgtc      540

gggctgtccg cgattcaggc ggcccacgcc atcggcgctc aggtgattgc cgtggacatc      600

gacgacgaca agctggagaa ggcgcggacc gaaggcgccg cggtgaccat caacagccgg      660

cgcgaggaac gcgtgttcaa ggccatcaag caggtcacgc gcggaggcgc gcacgtgagc      720

atcgacgcgc tcgggctcgc cgagacggtg ttcaactcgg tgcggtgcct gcgcaaaggc      780

gggcgccatg tacaggtcgg cctcacctcc tcgtccgagc agggcatggt ggcgctgccg      840

gtcgacatca tgaccacggg cgagatcgag ttcatcggaa gctttggcaa cccgcacgtc      900

gccttcgacg gcttgttgcg gttggtcgcc gcagggaggc tccggcccaa ggcgctcgtg      960

gagcgcgagg tgagcctcgc cgagttgaac gacgtgttcc atcgcatgct gcgcttcgag     1020

acgaaggggt tcaacgtgat cacggcgttc gcgtga                               1056


<210>   986
<211>   1056
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 971

<400>   986
gtgaaagctg cgcgcctgca cgcattccac acgccctttg ccatcgagac cgtcccagat       60

cccgaacctg gcccggagga agccatcgtc cgcgtgcgtg cggccggcgt gtgccggagc      120

gatcttcaca tctggcaggg ggagctcgct tgggtcggga ttcggccgca gttgcccatc      180

accctgggcc acgaattcgg cggcgaggtg gtggcggtgg ggcgcaatgt ccgccgcttt      240

gtggcgggcg atcgcgtcac cgtcccgttc cacaacggct gcggccgatg cccgcagtgc      300

cagtcgggca ggtcgaatct ttgcgacgag ttcggattct acggcgccac gtatgacggg      360

tgcttcgccg aatacgtgcg tgtccccaac gccgacttca acctcatcca tttgcccgac      420

gaggtcgatt tcgtcacggc ggccgccatg gggtgccgct acatgacggg ctttcatgct      480

gtgatgcggg ggcgcgtcca gcccggtgaa tgggtggccg tgcacggcgc gggcggcgtc      540

gggctgtccg cgattcaggc ggcccacgcc atcggcgctc aggtgattgc cgtggacatc      600

gacgacgaca agctggagaa ggcgcggacc gaaggcgccg cggtgaccat caacagccgg      660

cgcgaggaac gcgtgttcaa ggccatcaag caggtcacgc gcggaggcgc gcacgtgagc      720

atcgacgcgc tcgggctcgc cgagacggtg ttcaactcgg tgcggtgcct gcgcaaaggc      780

gggcgccatg tacaggtcgg cctcacctcc tcgtccgagc agggcatggt ggcgctgccg      840

gtcgacatca tgaccacggg cgagatcgag ttcatcggaa gctttggcaa cccgcacgtc      900

gccttcgacg gcttgttgcg gttggtcgcc gcagggaggc tccggcccaa ggcgctcgtg      960

gagcgcgagg tgagcctcgc cgagttgaac gacgtgttcc atcgcatgct gcgcttcgag     1020

acgaaggggt tcaacgtgat cacggcgttc gcgtga                               1056


<210>   987
<211>   377
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   987
Met Gln Thr Arg Ala Ala Val Leu Met Glu Met Gly Ala Arg Pro Pro 
                5                   10                  15      

Tyr Ala Ser Thr Arg Pro Leu Arg Leu Glu Thr Leu Glu Leu Glu Pro 
            20                  25                  30          

Pro Gly Pro Gly Glu Val Leu Ile Arg Val Arg Ala Ala Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Glu Gly Ala Arg Pro Arg Pro Met Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Ala Gly Glu Val Val Glu Leu Gly Glu 
65                  70                  75                  80  

Gly Val Thr Asp Leu Ala Pro Gly Asp His Val Val Cys Ala Phe Val 
                85                  90                  95      

Pro Ser Cys Gly His Cys Ala Pro Cys Gln Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Pro Gly Ala Glu Ala Asn Gly Arg Gly Thr Leu Leu Ser Gly 
        115                 120                 125             

Ala Arg Arg Leu Arg Leu Gly Gly Gln Pro Val His His His Leu Gly 
    130                 135                 140                 

Val Ser Ala Phe Ser Asp Tyr Ala Val Val Ser Arg Arg Ser Leu Val 
145                 150                 155                 160 

Arg Ile Asp Pro Ser Leu Pro Phe Glu His Ala Ala Leu Phe Gly Cys 
                165                 170                 175     

Ala Val Met Thr Gly Val Gly Ala Ile Val Asn Thr Ala Arg Val Pro 
            180                 185                 190         

Val Gly Ala Ser Val Gly Ile Val Gly Leu Gly Gly Val Gly Leu Ala 
        195                 200                 205             

Ala Leu Leu Gly Ala Val Ala Ser Ser Ala Arg His Ile Ala Ala Ile 
    210                 215                 220                 

Asp Val Asn Pro Glu Lys Leu Ala Phe Ala Arg Glu Leu Gly Ala Thr 
225                 230                 235                 240 

His Thr Tyr Asp Ala Arg Asp Pro Gly Val Ile Asp Lys Val Arg Ala 
                245                 250                 255     

Asp Ser Ala Gly Gly Leu Glu Tyr Val Phe Glu Thr Ala Gly Ser Val 
            260                 265                 270         

Ala Ala Met Lys Thr Ala Phe Met Val Thr Arg Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro Asp Pro Arg His Glu Trp Ser Val Pro Gln 
    290                 295                 300                 

Val Leu Leu Ala Ala Glu Glu Arg Thr Ile Arg Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Ile Pro Ser Arg Asp Ile Pro Arg Phe Ile Ser Leu Phe Gln 
                325                 330                 335     

Gln Gly Lys Leu Pro Val Asp Arg Leu Val Ser Asp Val Ile Asp Leu 
            340                 345                 350         

Asp His Ile Asn Glu Gly Phe Asp Arg Leu Ala Ala Gly Glu Ala Val 
        355                 360                 365             

Arg Ile Val Val Arg Met Ser Gly Ala 
    370                 375         

<210>   988
<211>   1134
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   988
gtgcagacgc gagccgctgt cctcatggag atgggggcga ggccgcctta tgcatccaca       60

aggccgcttc gcctggagac gctggaactg gaaccgccag ggccgggcga ggtcctcatc      120

cgggtgcgcg ccgccggcct gtgtcattcg gatctgtccg tcattgaggg cgcccgcccg      180

cggccgatgc cgatggccct tggccacgag gcggctggcg aggtggtgga gctcggcgaa      240

ggagtgacgg acctcgcgcc gggcgatcac gtcgtctgcg cctttgtgcc aagctgcggg      300

cactgcgccc cctgtcaaga gggccggcca gcgctctgcg agccgggcgc cgaggccaac      360

ggccgcggca cgctgctctc cggcgcgcgc aggctgcgcc ttggcggaca gcccgtccat      420

caccacctcg gcgtgtcggc cttcagcgac tacgccgtcg tctcgcgccg ctcgctggtg      480

agaatcgatc cgtccctccc gttcgagcac gcggcgctgt ttggctgcgc ggtcatgacg      540

ggcgtcggcg cgatcgtcaa cacggcgcgc gtccctgtag gcgcctcggt cggcatcgtc      600

ggcctcggcg gggtgggact cgccgcgctg ctcggcgcgg tggcttcgtc cgcccggcac      660

atcgcggcca tcgacgtgaa ccccgagaaa ctggcgttcg cgcgcgaact cggcgcaacg      720

cacacgtacg acgcgcgcga tcccggcgtg attgacaagg tgcgcgcgga ttcggcgggc      780

ggcttggagt acgtgttcga gacggcgggc tccgtcgcgg ccatgaagac ggcgttcatg      840

gtgacgcggc gcggcggcac gaccgtgacc acagggctgc cggatcctcg gcacgagtgg      900

agcgtgcccc aggtgctgct tgcggccgag gagcgcacca ttcggggctc gtacgtcgga      960

agctgcatcc cgtcccgcga catcccgcgc ttcatttcct tgtttcagca agggaagctc     1020

cctgtcgacc ggctcgtgtc ggacgtgatc gatctcgacc acatcaacga gggcttcgac     1080

cgcctggctg cgggtgaggc ggtgcgcatc gtggtgcgaa tgagtggtgc ctaa           1134


<210>   989
<211>   375
<212>   PRT
<213>   Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

<400>   989
Met Lys Thr Arg Ala Ala Val Leu Arg Glu Met Gly Lys Asp Ala Pro 
                5                   10                  15      

Tyr Thr Glu Ser His Pro Leu Thr Ile Glu Thr Leu Glu Leu Gln Gly 
            20                  25                  30          

Pro Gln Ser Asn Glu Val Leu Ile Lys Ile Gly Ala Val Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Asn Gly Ser Arg Pro Arg Pro Met Pro 
    50                  55                  60                  

Met Val Leu Gly His Glu Ala Ala Gly Glu Ile Ile Glu Val Gly Glu 
65                  70                  75                  80  

Asn Val Ala Glu Phe Glu Val Gly Asp His Ile Val Cys Thr Phe Ile 
                85                  90                  95      

Pro Ser Cys Gly His Cys Ile Pro Cys Arg Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Asn Gly Ala Ala Ala Asn Glu Lys Gly Glu Met Leu Glu Gly 
        115                 120                 125             

Gly Phe Arg Tyr Glu Ser Asp Arg Asp Glu Val Met His His His Leu 
    130                 135                 140                 

Gly Val Ser Gly Phe Ala Asp Tyr Ala Val Val Ser Thr Asn Ser Ile 
145                 150                 155                 160 

Val Lys Val Asp Lys Lys Ile Pro Phe Glu Lys Val Ala Ile Phe Gly 
                165                 170                 175     

Cys Ala Val Ile Thr Gly Ile Gly Ala Val Ile Asn Thr Ala Arg Ile 
            180                 185                 190         

Asn Ala Gly Ser Thr Val Ala Val Val Gly Leu Gly Gly Ile Gly Leu 
        195                 200                 205             

Asn Ala Ile Leu Gly Ala Arg Leu Ala Gly Ala Ser Glu Ile Ile Ala 
    210                 215                 220                 

Leu Asp Ile Asn Glu Glu Lys Phe Ala Leu Ala Lys Ser Leu Gly Ala 
225                 230                 235                 240 

Thr Ala Val Phe Asn Ser Gly Glu Ala His Thr Ile Glu Asp Ile Lys 
                245                 250                 255     

Gln Tyr Thr Gln Gly Gly Val Asp Tyr Ala Phe Glu Thr Ala Gly Val 
            260                 265                 270         

Val Pro Ala Met Asp Val Ala Tyr Gln Ile Thr Arg Arg Gly Gly Met 
        275                 280                 285             

Thr Thr Thr Thr Gly Leu Pro Asp Pro Lys His Gln Phe Ser Phe Pro 
    290                 295                 300                 

Gln Val Thr Leu Ala Ala Glu Glu Arg Thr Ile Lys Gly Ser Tyr Val 
305                 310                 315                 320 

Gly Ser Cys Val Pro Asp Arg Asp Ile Pro Arg Phe Ile Asn Leu Tyr 
                325                 330                 335     

His Gln Gly Arg Leu Pro Val Asn Glu Leu Leu Thr Asp Thr Leu Pro 
            340                 345                 350         

Leu Glu His Ile Asn Glu Gly Phe Asp Arg Leu Ala Arg Gly Glu Ala 
        355                 360                 365             

Ala Arg Leu Val Val Lys Met 
    370                 375 

<210>   990
<211>   374
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   990
Met Gln Val Lys Thr Ala Val Leu Arg Thr Gln Gly Ala Asp Ser Pro 
                5                   10                  15      

Tyr Lys Glu Ser Lys Pro Ile Lys Ile Glu Thr Leu Glu Leu Asp Ala 
            20                  25                  30          

Pro Gln Leu Gly Glu Val Leu Ile Gln Ile Lys Ala Ala Ser Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Asn Gly Ser Arg Pro Arg Pro Leu Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Ser Gly Val Val Val Glu Val Gly Glu 
65                  70                  75                  80  

Gly Val Thr Tyr Leu Glu Pro Gly Asp His Ile Val Cys Val Phe Val 
                85                  90                  95      

Pro Ser Cys Gly His Cys Val Pro Cys Lys Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Pro Gly Ala Asp Ser Asn Thr Ala Gly Thr Leu Ile Ser Gly 
        115                 120                 125             

Gly Ile Arg Leu His Ala Asp Gly Glu Ala Ile Asn His His Leu Gly 
    130                 135                 140                 

Val Ser Ala Phe Ser Glu Phe Ala Val Val Ser Arg Asn Ser Leu Val 
145                 150                 155                 160 

Lys Val Lys Lys Asp Ile Pro Phe Glu Lys Leu Ala Leu Phe Gly Cys 
                165                 170                 175     

Ala Val Ile Thr Gly Val Gly Ala Val Val Asn Thr Ala Asn Val Lys 
            180                 185                 190         

Leu Gly Ser Thr Val Ala Ile Val Gly Leu Gly Gly Ile Gly Leu Ser 
        195                 200                 205             

Ala Leu Leu Gly Ala Val Ala Ala Gly Ala Ser Arg Ile Ile Ala Val 
    210                 215                 220                 

Asp Ile Asn Glu Asn Lys Leu Lys Gln Ala Lys Glu Leu Gly Ala Thr 
225                 230                 235                 240 

Asp Val Phe Asn Ser Thr Glu Glu Thr Val Ile Gln Gln Ile Lys Glu 
                245                 250                 255     

Ala Thr Asp Gly Gly Val Asn Tyr Ala Phe Glu Thr Ala Gly Ala Val 
            260                 265                 270         

Pro Ala Met Glu Val Ala Tyr Gly Ile Thr Lys Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro His Pro Glu His Gln Phe Ser Phe Pro Tyr 
    290                 295                 300                 

Val Thr Leu Thr Ala Glu Glu Lys Thr Leu Lys Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Val Pro Asp Arg Asp Ile Pro Arg Tyr Met Asn Leu Phe Lys 
                325                 330                 335     

Gln Asp Arg Leu Pro Val Asp Lys Leu Met Thr Asp Phe Ile Ser Leu 
            340                 345                 350         

Asp Glu Ile Asn Glu Gly Phe Asp Lys Leu Ala Lys Gly Asp Ser Ser 
        355                 360                 365             

Arg Ile Ile Ile Lys Met 
    370                 

<210>   991
<211>   374
<212>   PRT
<213>   Staphylococcus epidermidis RP62A

<400>   991
Met Lys Thr Arg Ala Ala Val Leu Tyr Glu Met Gly Ala Lys Lys Pro 
                5                   10                  15      

Tyr Lys Glu Ser Lys Pro Leu Lys Ile Glu Tyr Leu Glu Leu Asp Asn 
            20                  25                  30          

Pro Ser Glu His Glu Val Leu Ile Lys Ile His Ala Ala Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Asn Gly Asn Arg Pro Arg Pro Leu Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Ser Gly Glu Val Ile Lys Val Gly Lys 
65                  70                  75                  80  

Ala Val Thr Arg Val Ser Glu Gly Asp His Val Val Cys Thr Phe Ile 
                85                  90                  95      

Pro Ser Cys Gly Lys Cys Ile Pro Cys Lys Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Asn Gly Ala Ile Ser Asn Glu Lys Gly Glu Met Leu Glu Gly 
        115                 120                 125             

Gly Met Arg Leu Ser Asn Asp Glu Gly Lys Val Tyr His His Leu Gly 
    130                 135                 140                 

Ile Ser Gly Phe Ala Glu Tyr Ser Val Val Ser Glu Asn Ser Ile Val 
145                 150                 155                 160 

Lys Ile Asp Lys Lys Ile Pro Phe Glu Arg Ala Ala Ala Phe Gly Cys 
                165                 170                 175     

Ala Ile Ile Thr Gly Ile Gly Ala Val Val Asn Thr Ala Gln Ile Arg 
            180                 185                 190         

Ser Gly Ser Asn Val Ala Val Val Gly Leu Gly Gly Ile Gly Leu Asn 
        195                 200                 205             

Ala Ile Ile Gly Ala Lys Leu Ala Gly Ala Asn Glu Ile Ile Ala Leu 
    210                 215                 220                 

Asp Ile Asn Glu Asp Lys Phe Glu Leu Ala Lys Gln Phe Gly Ala Thr 
225                 230                 235                 240 

Ala Thr Phe Asn Ser Ser Asp Lys Asp Ile Asp Glu Gln Ile Lys Glu 
                245                 250                 255     

Tyr Ile Pro Gly Gly Val Glu Tyr Ala Phe Glu Thr Ala Gly Val Val 
            260                 265                 270         

Pro Ala Met Lys Val Ala Tyr Gln Ile Thr Lys Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro Asn Pro Lys Asp Asn Phe Ser Phe Pro Gln 
    290                 295                 300                 

Val Thr Leu Ala Ala Glu Glu Arg Thr Ile Lys Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Val Pro Asp Arg Asp Ile Pro Arg Phe Val Asn Leu Tyr Asn 
                325                 330                 335     

Gln Gly Arg Leu Asn Ile Asp Ser Leu Ile Ser Glu Val Ile Thr Leu 
            340                 345                 350         

Asp Glu Ile Asn Glu Gly Phe Asp Arg Leu Ser Asn Gly Glu Val Gly 
        355                 360                 365             

Arg Ile Ile Met Lys Met 
    370                 

<210>   992
<211>   374
<212>   PRT
<213>   Staphylococcus haemolyticus JCSC1435

<400>   992
Met Lys Thr Arg Ala Ala Val Leu Tyr Glu Met Glu Ala Ser Gln Pro 
                5                   10                  15      

Tyr Lys Glu Ser Lys Pro Leu Lys Ile Glu Ser Leu Glu Leu Glu Asp 
            20                  25                  30          

Pro His Glu His Glu Val Leu Leu Lys Ile His Ala Ala Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Asn Gly Ser Arg Pro Arg Pro Leu Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Thr Gly Glu Val Leu Lys Val Gly Ser 
65                  70                  75                  80  

Ser Val Thr Arg Val Lys Glu Gly Asp His Val Val Cys Thr Phe Ile 
                85                  90                  95      

Pro Ser Cys Gly Lys Cys Ile Pro Cys Lys Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Asn Gly Ala Lys Ala Asn Glu Lys Gly Glu Met Leu Glu Gly 
        115                 120                 125             

Gly Ile Arg Leu Ser Asn Glu Asp Gly Gln Val Tyr His His Leu Gly 
    130                 135                 140                 

Val Ser Gly Phe Ala Glu His Ala Val Val Ser Glu Asn Ser Ile Val 
145                 150                 155                 160 

Lys Ile Ser Asn Glu Ile Pro Phe Glu Arg Ala Ala Val Phe Gly Cys 
                165                 170                 175     

Ala Val Ile Thr Gly Ile Gly Ala Val Met Asn Thr Ala Gln Ile Arg 
            180                 185                 190         

Pro Gly Ser Asn Val Ala Val Val Gly Leu Gly Gly Ile Gly Leu Asn 
        195                 200                 205             

Ala Ile Ile Gly Ala Lys Leu Ala Gly Ala Asn Glu Ile Ile Ala Leu 
    210                 215                 220                 

Asp Ile Asn Glu Asp Lys Phe Asp Leu Ala Lys Gln Phe Gly Ala Thr 
225                 230                 235                 240 

Ala Thr Phe Asn Ser Ser Asp Asp Asp Ile Asp Glu Gln Ile Lys Glu 
                245                 250                 255     

Tyr Val Pro Gly Gly Val Glu Tyr Ala Phe Glu Thr Ala Gly Val Val 
            260                 265                 270         

Pro Ala Met Gln Val Ala Tyr Arg Ile Thr Lys Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro His Pro Lys Asp Glu Phe Ser Phe Pro Gln 
    290                 295                 300                 

Val Thr Leu Ala Ala Glu Glu Arg Thr Val Lys Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Val Pro Asp Arg Asp Ile Pro Arg Phe Val Ser Leu Tyr Lys 
                325                 330                 335     

Gln Gly Arg Leu Asn Ile Asp Pro Leu Ile Ser Glu Val Ile Thr Leu 
            340                 345                 350         

Asp Asp Ile Asn Glu Gly Phe Asp Lys Leu Ala Ser Gly Asp Val Gly 
        355                 360                 365             

Arg Ile Ile Val Lys Met 
    370                 

<210>   993
<211>   370
<212>   PRT
<213>   Aurantimonas sp. SI85-9A1

<400>   993
Thr Arg Ala Ala Val Leu Arg Arg Ser Pro Val Glu Gly Pro Tyr Ala 
                5                   10                  15      

Thr Ser Arg Pro Leu Ser Ile Glu Thr Val Glu Leu Ala Pro Pro Gly 
            20                  25                  30          

Asp Gly Glu Val Leu Val Arg Ile Lys Ala Ala Gly Leu Cys His Ser 
        35                  40                  45              

Asp Leu Ser Val Ile Asp Gly Val Arg Pro Arg Pro Thr Pro Met Val 
    50                  55                  60                  

Leu Gly His Glu Ala Ala Gly Ile Val Glu Thr Val Gly Ala Gly Val 
65                  70                  75                  80  

Asp Asp Leu Ala Pro Gly Asp His Val Val Met Val Phe Val Pro Ser 
                85                  90                  95      

Cys Gly His Cys Ser Pro Cys Ala Glu Gly Arg Pro Ala Leu Cys Glu 
            100                 105                 110         

Pro Gly Asn Ala Arg Asn Gly Glu Gly Thr Leu Leu Ser Gly Glu Arg 
        115                 120                 125             

Arg Leu Ser Cys Glu Gly Glu Pro Val His His His Leu Gly Val Ser 
    130                 135                 140                 

Ala Phe Ala Glu Arg Ser Val Leu Ser Arg Arg Ser Leu Ile Lys Ile 
145                 150                 155                 160 

Asp Pro Glu Leu Pro Leu Glu Ile Ala Ala Leu Phe Gly Cys Ala Val 
                165                 170                 175     

Leu Thr Gly Val Gly Ala Val Val Asn Thr Gly Arg Val Lys Ala Gly 
            180                 185                 190         

Glu Thr Val Ala Val Val Gly Leu Gly Gly Val Gly Leu Ser Ala Ile 
        195                 200                 205             

Leu Gly Ala Val Ala Ala Gly Ala Ser Arg Ile Ile Ala Val Asp Leu 
    210                 215                 220                 

Gln Ala Asp Lys Leu Asp Met Ala Lys Thr Leu Gly Ala Thr Asp Ile 
225                 230                 235                 240 

Phe Asn Ala Gly Glu Ala Gly Val Ala Asp Ala Val Arg Ala Ala Thr 
                245                 250                 255     

Gly Gly Gly Val Asp His Ala Phe Glu Met Ala Gly Ser Ala Arg Ala 
            260                 265                 270         

Leu Glu Leu Ala Phe Ala Ile Thr Arg Arg Gly Gly Ala Thr Val Thr 
        275                 280                 285             

Ala Gly Leu Thr Pro Pro Thr Ala Thr Met Ala Leu Ser Pro Leu Lys 
    290                 295                 300                 

Leu Val Ala Glu Glu Arg Thr Leu Lys Gly Ser Tyr Val Gly Ser Cys 
305                 310                 315                 320 

Ile Pro Ser Arg Asp Ile Pro Arg Tyr Ile Ala Leu Tyr Arg Gly Gly 
                325                 330                 335     

Arg Leu Pro Val Asp Arg Leu Leu Thr Ser Arg Gly Thr Leu Asp Asp 
            340                 345                 350         

Ile Asn Glu Gly Phe Asp Ala Leu Ala Ala Gly Arg Thr Val Arg His 
        355                 360                 365             

Val Val 
    370 

<210>   994
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 987

<400>   994
Met Gln Thr Arg Ala Ala Val Leu Met Glu Met Gly Ala Arg Pro Pro 
                5                   10                  15      

Tyr Ala Ser Thr Arg Pro Leu Arg Leu Glu Thr Leu Glu Leu Glu Pro 
            20                  25                  30          

Pro Gly Pro Gly Glu Val Leu Ile Arg Val Arg Ala Ala Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Glu Gly Ala Arg Pro Arg Pro Met Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Ala Gly Glu Val Val Glu Leu Gly Glu 
65                  70                  75                  80  

Gly Val Thr Asp Leu Ala Pro Gly Asp His Val Val Cys Ala Phe Val 
                85                  90                  95      

Pro Ser Cys Gly His Cys Ala Pro Cys Gln Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Pro Gly Ala Glu Ala Asn Gly Arg Gly Thr Leu Leu Ser Gly 
        115                 120                 125             

Ala Arg Arg Leu Arg Leu Gly Gly Gln Pro Val His His His Leu Gly 
    130                 135                 140                 

Val Ser Ala Phe Ser Asp Tyr Ala Val Val Ser Arg Arg Ser Leu Val 
145                 150                 155                 160 

Arg Ile Asp Pro Ser Leu Pro Phe Glu His Ala Ala Leu Phe Gly Cys 
                165                 170                 175     

Ala Val Met Thr Gly Val Gly Ala Ile Val Asn Thr Ala Arg Val Pro 
            180                 185                 190         

Val Gly Ala Ser Val Gly Ile Val Gly Leu Gly Gly Val Gly Leu Ala 
        195                 200                 205             

Ala Leu Leu Gly Ala Val Ala Ser Ser Ala Arg His Ile Ala Ala Ile 
    210                 215                 220                 

Asp Val Asn Pro Glu Lys Leu Ala Phe Ala Arg Glu Leu Gly Ala Thr 
225                 230                 235                 240 

His Thr Tyr Asp Ala Arg Asp Pro Gly Val Ile Asp Lys Val Arg Ala 
                245                 250                 255     

Asp Ser Ala Gly Gly Leu Glu Tyr Val Phe Glu Thr Ala Gly Ser Val 
            260                 265                 270         

Ala Ala Met Lys Thr Ala Phe Met Val Thr Arg Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro Asp Pro Arg His Glu Trp Ser Val Pro Gln 
    290                 295                 300                 

Val Leu Leu Ala Ala Glu Glu Arg Thr Ile Arg Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Ile Pro Ser Arg Asp Ile Pro Arg Phe Ile Ser Leu Phe Gln 
                325                 330                 335     

Gln Gly Lys Leu Pro Val Asp Arg Leu Val Ser Asp Ile Ile Asp Leu 
            340                 345                 350         

Asp His Ile Asn Glu Gly Phe Asp Arg Leu Ala Ala Gly Glu Ala Val 
        355                 360                 365             

Arg Ile Val Val Arg Met Ser Gly Ala 
    370                 375         

<210>   995
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 987

<400>   995
Met Gln Thr Arg Ala Ala Val Leu Met Glu Met Gly Ala Arg Pro Pro 
                5                   10                  15      

Tyr Ala Ser Thr Arg Pro Leu Arg Leu Glu Thr Leu Glu Leu Glu Pro 
            20                  25                  30          

Pro Gly Pro Gly Glu Val Leu Ile Arg Val Arg Ala Ala Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Glu Gly Ala Arg Pro Arg Pro Met Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Ala Gly Glu Val Val Glu Leu Gly Glu 
65                  70                  75                  80  

Gly Val Thr Asp Leu Ala Pro Gly Asp His Val Val Cys Ala Phe Val 
                85                  90                  95      

Pro Ser Cys Gly His Cys Ala Pro Cys Gln Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Pro Gly Ala Glu Ala Asn Gly Arg Gly Thr Leu Leu Ser Gly 
        115                 120                 125             

Ala Arg Arg Leu Arg Leu Gly Gly Gln Pro Val His His His Leu Gly 
    130                 135                 140                 

Val Ser Ala Phe Ser Asp Tyr Ala Val Val Ser Arg Arg Ser Leu Val 
145                 150                 155                 160 

Arg Ile Asp Pro Ser Leu Pro Phe Glu His Ala Ala Leu Phe Gly Cys 
                165                 170                 175     

Ala Val Met Thr Gly Val Gly Ala Ile Val Asn Thr Ala Arg Val Pro 
            180                 185                 190         

Val Gly Ala Ser Val Gly Ile Val Gly Leu Gly Gly Val Gly Leu Ala 
        195                 200                 205             

Ala Leu Leu Gly Ala Val Ala Ser Ser Ala Arg His Ile Ala Ala Ile 
    210                 215                 220                 

Asp Val Asn Pro Glu Lys Leu Ala Phe Ala Arg Glu Leu Gly Ala Thr 
225                 230                 235                 240 

His Thr Tyr Asp Ala Arg Asp Pro Gly Val Ile Asp Lys Val Arg Ala 
                245                 250                 255     

Asp Ser Ala Gly Gly Leu Glu Tyr Val Phe Glu Thr Ala Gly Ser Val 
            260                 265                 270         

Ala Ala Met Lys Thr Ala Phe Met Val Thr Arg Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro Asp Pro Arg His Asp Trp Ser Val Pro Gln 
    290                 295                 300                 

Val Leu Leu Ala Ala Glu Glu Arg Thr Ile Arg Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Ile Pro Ser Arg Asp Ile Pro Arg Phe Ile Ser Leu Phe Gln 
                325                 330                 335     

Gln Gly Lys Leu Pro Val Asp Arg Leu Val Ser Asp Val Ile Asp Leu 
            340                 345                 350         

Asp His Ile Asn Glu Gly Phe Asp Arg Leu Ala Ala Gly Glu Ala Val 
        355                 360                 365             

Arg Ile Val Val Arg Met Ser Gly Ala 
    370                 375         

<210>   996
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 987

<400>   996
Met Gln Thr Arg Ala Ala Val Leu Met Glu Met Gly Ala Arg Pro Pro 
                5                   10                  15      

Tyr Ala Ser Thr Arg Pro Leu Arg Leu Glu Thr Leu Glu Leu Glu Pro 
            20                  25                  30          

Pro Gly Pro Gly Glu Val Leu Ile Arg Val Arg Ala Ala Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Glu Gly Ala Arg Pro Arg Pro Met Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Ala Gly Glu Val Val Glu Leu Gly Glu 
65                  70                  75                  80  

Gly Val Thr Glu Leu Ala Pro Gly Asp His Val Val Cys Ala Phe Val 
                85                  90                  95      

Pro Ser Cys Gly His Cys Ala Pro Cys Gln Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Pro Gly Ala Glu Ala Asn Gly Arg Gly Thr Leu Leu Ser Gly 
        115                 120                 125             

Ala Arg Arg Leu Arg Leu Gly Gly Gln Pro Val His His His Leu Gly 
    130                 135                 140                 

Val Ser Ala Phe Ser Asp Tyr Ala Val Val Ser Arg Arg Ser Leu Val 
145                 150                 155                 160 

Arg Ile Asp Pro Ser Leu Pro Phe Glu His Ala Ala Leu Phe Gly Cys 
                165                 170                 175     

Ala Val Met Thr Gly Val Gly Ala Ile Val Asn Thr Ala Arg Val Pro 
            180                 185                 190         

Val Gly Ala Ser Val Gly Ile Val Gly Leu Gly Gly Val Gly Leu Ala 
        195                 200                 205             

Ala Leu Leu Gly Ala Val Ala Ser Ser Ala Arg His Ile Ala Ala Ile 
    210                 215                 220                 

Asp Val Asn Pro Glu Lys Leu Ala Phe Ala Arg Glu Leu Gly Ala Thr 
225                 230                 235                 240 

His Thr Tyr Asp Ala Arg Asp Pro Gly Val Ile Asp Lys Val Arg Ala 
                245                 250                 255     

Asp Ser Ala Gly Gly Leu Glu Tyr Val Phe Glu Thr Ala Gly Ser Val 
            260                 265                 270         

Ala Ala Met Lys Thr Ala Phe Met Val Thr Arg Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro Asp Pro Arg His Glu Trp Ser Val Pro Gln 
    290                 295                 300                 

Val Leu Leu Ala Ala Glu Glu Arg Thr Ile Arg Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Ile Pro Ser Arg Asp Ile Pro Arg Phe Ile Ser Leu Phe Gln 
                325                 330                 335     

Gln Gly Lys Leu Pro Val Asp Arg Leu Val Ser Asp Val Ile Asp Leu 
            340                 345                 350         

Asp His Ile Asn Glu Gly Phe Asp Arg Leu Ala Ala Gly Glu Ala Val 
        355                 360                 365             

Arg Ile Val Val Arg Met Ser Gly Ala 
    370                 375         

<210>   997
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 987

<400>   997
Met Gln Thr Arg Ala Ala Val Leu Met Glu Met Gly Ala Arg Pro Pro 
                5                   10                  15      

Tyr Ala Ser Thr Arg Pro Leu Arg Leu Glu Thr Leu Glu Leu Glu Pro 
            20                  25                  30          

Pro Gly Pro Gly Glu Val Leu Ile Arg Val Arg Ala Ala Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Glu Gly Ala Arg Pro Arg Pro Met Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Ala Gly Glu Val Val Glu Leu Gly Glu 
65                  70                  75                  80  

Gly Val Thr Asp Leu Ala Pro Gly Asp His Val Val Cys Ala Phe Val 
                85                  90                  95      

Pro Ser Cys Gly His Cys Ala Pro Cys Asn Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Pro Gly Ala Glu Ala Asn Gly Arg Gly Thr Leu Leu Ser Gly 
        115                 120                 125             

Ala Arg Arg Leu Arg Leu Gly Gly Gln Pro Val His His His Leu Gly 
    130                 135                 140                 

Val Ser Ala Phe Ser Asp Tyr Ala Val Val Ser Arg Arg Ser Leu Val 
145                 150                 155                 160 

Arg Ile Asp Pro Ser Leu Pro Phe Glu His Ala Ala Leu Phe Gly Cys 
                165                 170                 175     

Ala Val Met Thr Gly Val Gly Ala Ile Val Asn Thr Ala Arg Val Pro 
            180                 185                 190         

Val Gly Ala Ser Val Gly Ile Val Gly Leu Gly Gly Val Gly Leu Ala 
        195                 200                 205             

Ala Leu Leu Gly Ala Val Ala Ser Ser Ala Arg His Ile Ala Ala Ile 
    210                 215                 220                 

Asp Val Asn Pro Glu Lys Leu Ala Phe Ala Arg Glu Leu Gly Ala Thr 
225                 230                 235                 240 

His Thr Tyr Asp Ala Arg Asp Pro Gly Val Ile Asp Lys Val Arg Ala 
                245                 250                 255     

Asp Ser Ala Gly Gly Leu Glu Tyr Val Phe Glu Thr Ala Gly Ser Val 
            260                 265                 270         

Ala Ala Met Lys Thr Ala Phe Met Val Thr Arg Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro Asp Pro Arg His Glu Trp Ser Val Pro Gln 
    290                 295                 300                 

Val Leu Leu Ala Ala Glu Glu Arg Thr Ile Arg Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Ile Pro Ser Arg Asp Ile Pro Arg Phe Ile Ser Leu Phe Gln 
                325                 330                 335     

Gln Gly Lys Leu Pro Val Asp Arg Leu Val Ser Asp Val Ile Asp Leu 
            340                 345                 350         

Asp His Ile Asn Glu Gly Phe Asp Arg Leu Ala Ala Gly Glu Ala Val 
        355                 360                 365             

Arg Ile Val Val Arg Met Ser Gly Ala 
    370                 375         

<210>   998
<211>   377
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 987

<400>   998
Met Gln Thr Arg Ala Ala Val Leu Met Glu Met Gly Ala Arg Pro Pro 
                5                   10                  15      

Tyr Ala Ser Thr Arg Pro Leu Arg Leu Glu Thr Leu Glu Leu Glu Pro 
            20                  25                  30          

Pro Gly Pro Gly Glu Val Leu Ile Arg Val Arg Ala Ala Gly Leu Cys 
        35                  40                  45              

His Ser Asp Leu Ser Val Ile Glu Gly Ala Arg Pro Arg Pro Met Pro 
    50                  55                  60                  

Met Ala Leu Gly His Glu Ala Ala Gly Glu Val Val Glu Leu Gly Glu 
65                  70                  75                  80  

Gly Val Thr Asp Leu Ala Pro Gly Asp His Val Val Cys Ala Phe Val 
                85                  90                  95      

Pro Ser Cys Gly His Cys Ala Pro Cys Gln Glu Gly Arg Pro Ala Leu 
            100                 105                 110         

Cys Glu Pro Gly Ala Glu Ala Asn Gly Arg Gly Thr Leu Leu Ser Gly 
        115                 120                 125             

Ala Arg Arg Leu Arg Leu Gly Gly Gln Pro Val His His His Leu Gly 
    130                 135                 140                 

Val Ser Ala Phe Ser Asp Tyr Ala Val Val Ser Arg Arg Ser Leu Val 
145                 150                 155                 160 

Arg Ile Asp Pro Ser Leu Pro Phe Glu His Ala Ala Leu Phe Gly Cys 
                165                 170                 175     

Ala Val Met Thr Gly Val Gly Ala Ile Val Asn Thr Ala Arg Val Pro 
            180                 185                 190         

Val Gly Ala Ser Val Gly Ile Val Gly Leu Gly Gly Val Gly Leu Ala 
        195                 200                 205             

Ala Leu Leu Gly Ala Val Ala Ser Ser Ala Arg His Ile Ala Ala Ile 
    210                 215                 220                 

Asp Val Asn Pro Glu Lys Leu Ala Phe Ala Arg Glu Leu Gly Ala Thr 
225                 230                 235                 240 

His Thr Tyr Asp Ala Arg Asp Pro Gly Val Ile Asp Lys Val Arg Ala 
                245                 250                 255     

Asp Ser Ala Gly Gly Leu Glu Tyr Val Phe Glu Thr Ala Gly Ser Val 
            260                 265                 270         

Ala Ala Met Lys Thr Ala Phe Met Val Thr Arg Arg Gly Gly Thr Thr 
        275                 280                 285             

Val Thr Thr Gly Leu Pro Asp Pro Arg His Glu Trp Ser Val Pro Gln 
    290                 295                 300                 

Val Leu Leu Ala Ala Glu Glu Arg Thr Ile Arg Gly Ser Tyr Val Gly 
305                 310                 315                 320 

Ser Cys Ile Pro Ser Arg Asp Ile Pro Arg Phe Ile Ser Leu Phe Gln 
                325                 330                 335     

Gln Gly Lys Leu Pro Val Asp Arg Leu Val Ser Asp Val Leu Asp Leu 
            340                 345                 350         

Asp His Ile Asn Glu Gly Phe Asp Arg Leu Ala Ala Gly Glu Ala Val 
        355                 360                 365             

Arg Ile Val Val Arg Met Ser Gly Ala 
    370                 375         

<210>   999
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 988

<400>   999
gtgcagacgc gagccgctgt cctcatggag atgggggcga ggccgcctta tgcatccaca       60

aggccgcttc gcctggagac gctggaactg gaaccgccag ggccgggcga ggtcctcatc      120

cgggtgcgcg ccgccggcct gtgtcattcg gatctgtccg tcattgaggg cgcccgcccg      180

cggccgatgc cgatggccct tggccacgag gcggctggcg aggtggtgga gctcggcgaa      240

ggagtgacgg acctcgcgcc gggcgatcac gtcgtctgcg cctttgtgcc aagctgcggg      300

cactgcgccc cctgtcaaga gggccggcca gcgctctgcg agccgggcgc cgaggccaac      360

ggccgcggca cgctgctctc cggcgcgcgc aggctgcgcc ttggcggaca gcccgtccat      420

caccacctcg gcgtgtcggc cttcagcgac tacgccgtcg tctcgcgccg ctcgctggtg      480

agaatcgatc cgtccctccc gttcgagcac gcggcgctgt ttggctgcgc ggtcatgacg      540

ggcgtcggcg cgatcgtcaa cacggcgcgc gtccctgtag gcgcctcggt cggcatcgtc      600

ggcctcggcg gggtgggact cgccgcgctg ctcggcgcgg tggcttcgtc cgcccggcac      660

atcgcggcca tcgacgtgaa ccccgagaaa ctggcgttcg cgcgcgaact cggcgcaacg      720

cacacgtacg acgcgcgcga tcccggcgtg attgacaagg tgcgcgcgga ttcggcgggc      780

ggcttggagt acgtgttcga gacggcgggc tccgtcgcgg ccatgaagac ggcgttcatg      840

gtgacgcggc gcggcggcac gaccgtgacc acagggctgc cggatcctcg gcacgagtgg      900

agcgtgcccc aggtgctgct tgcggccgag gagcgcacca ttcggggctc gtacgtcgga      960

agctgcatcc cgtcccgcga catcccgcgc ttcatttcct tgtttcagca agggaagctc     1020

cctgtcgacc ggctcgtgtc ggacattatc gatctcgacc acatcaacga gggcttcgac     1080

cgcctggctg cgggtgaggc ggtgcgcatc gtggtgcgaa tgagtggtgc ctaa           1134


<210>   1000
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 988

<400>   1000
gtgcagacgc gagccgctgt cctcatggag atgggggcga ggccgcctta tgcatccaca       60

aggccgcttc gcctggagac gctggaactg gaaccgccag ggccgggcga ggtcctcatc      120

cgggtgcgcg ccgccggcct gtgtcattcg gatctgtccg tcattgaggg cgcccgcccg      180

cggccgatgc cgatggccct tggccacgag gcggctggcg aggtggtgga gctcggcgaa      240

ggagtgacgg acctcgcgcc gggcgatcac gtcgtctgcg cctttgtgcc aagctgcggg      300

cactgcgccc cctgtcaaga gggccggcca gcgctctgcg agccgggcgc cgaggccaac      360

ggccgcggca cgctgctctc cggcgcgcgc aggctgcgcc ttggcggaca gcccgtccat      420

caccacctcg gcgtgtcggc cttcagcgac tacgccgtcg tctcgcgccg ctcgctggtg      480

agaatcgatc cgtccctccc gttcgagcac gcggcgctgt ttggctgcgc ggtcatgacg      540

ggcgtcggcg cgatcgtcaa cacggcgcgc gtccctgtag gcgcctcggt cggcatcgtc      600

ggcctcggcg gggtgggact cgccgcgctg ctcggcgcgg tggcttcgtc cgcccggcac      660

atcgcggcca tcgacgtgaa ccccgagaaa ctggcgttcg cgcgcgaact cggcgcaacg      720

cacacgtacg acgcgcgcga tcccggcgtg attgacaagg tgcgcgcgga ttcggcgggc      780

ggcttggagt acgtgttcga gacggcgggc tccgtcgcgg ccatgaagac ggcgttcatg      840

gtgacgcggc gcggcggcac gaccgtgacc acagggctgc cggatcctcg gcacgattgg      900

agcgtgcccc aggtgctgct tgcggccgag gagcgcacca ttcggggctc gtacgtcgga      960

agctgcatcc cgtcccgcga catcccgcgc ttcatttcct tgtttcagca agggaagctc     1020

cctgtcgacc ggctcgtgtc ggacgtgatc gatctcgacc acatcaacga gggcttcgac     1080

cgcctggctg cgggtgaggc ggtgcgcatc gtggtgcgaa tgagtggtgc ctaa           1134


<210>   1001
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 988

<400>   1001
gtgcagacgc gagccgctgt cctcatggag atgggggcga ggccgcctta tgcatccaca       60

aggccgcttc gcctggagac gctggaactg gaaccgccag ggccgggcga ggtcctcatc      120

cgggtgcgcg ccgccggcct gtgtcattcg gatctgtccg tcattgaggg cgcccgcccg      180

cggccgatgc cgatggccct tggccacgag gcggctggcg aggtggtgga gctcggcgaa      240

ggagtgacgg aactcgcgcc gggcgatcac gtcgtctgcg cctttgtgcc aagctgcggg      300

cactgcgccc cctgtcaaga gggccggcca gcgctctgcg agccgggcgc cgaggccaac      360

ggccgcggca cgctgctctc cggcgcgcgc aggctgcgcc ttggcggaca gcccgtccat      420

caccacctcg gcgtgtcggc cttcagcgac tacgccgtcg tctcgcgccg ctcgctggtg      480

agaatcgatc cgtccctccc gttcgagcac gcggcgctgt ttggctgcgc ggtcatgacg      540

ggcgtcggcg cgatcgtcaa cacggcgcgc gtccctgtag gcgcctcggt cggcatcgtc      600

ggcctcggcg gggtgggact cgccgcgctg ctcggcgcgg tggcttcgtc cgcccggcac      660

atcgcggcca tcgacgtgaa ccccgagaaa ctggcgttcg cgcgcgaact cggcgcaacg      720

cacacgtacg acgcgcgcga tcccggcgtg attgacaagg tgcgcgcgga ttcggcgggc      780

ggcttggagt acgtgttcga gacggcgggc tccgtcgcgg ccatgaagac ggcgttcatg      840

gtgacgcggc gcggcggcac gaccgtgacc acagggctgc cggatcctcg gcacgagtgg      900

agcgtgcccc aggtgctgct tgcggccgag gagcgcacca ttcggggctc gtacgtcgga      960

agctgcatcc cgtcccgcga catcccgcgc ttcatttcct tgtttcagca agggaagctc     1020

cctgtcgacc ggctcgtgtc ggacgtgatc gatctcgacc acatcaacga gggcttcgac     1080

cgcctggctg cgggtgaggc ggtgcgcatc gtggtgcgaa tgagtggtgc ctaa           1134


<210>   1002
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 988

<400>   1002
gtgcagacgc gagccgctgt cctcatggag atgggggcga ggccgcctta tgcatccaca       60

aggccgcttc gcctggagac gctggaactg gaaccgccag ggccgggcga ggtcctcatc      120

cgggtgcgcg ccgccggcct gtgtcattcg gatctgtccg tcattgaggg cgcccgcccg      180

cggccgatgc cgatggccct tggccacgag gcggctggcg aggtggtgga gctcggcgaa      240

ggagtgacgg acctcgcgcc gggcgatcac gtcgtctgcg cctttgtgcc aagctgcggg      300

cactgcgccc cctgtaatga gggccggcca gcgctctgcg agccgggcgc cgaggccaac      360

ggccgcggca cgctgctctc cggcgcgcgc aggctgcgcc ttggcggaca gcccgtccat      420

caccacctcg gcgtgtcggc cttcagcgac tacgccgtcg tctcgcgccg ctcgctggtg      480

agaatcgatc cgtccctccc gttcgagcac gcggcgctgt ttggctgcgc ggtcatgacg      540

ggcgtcggcg cgatcgtcaa cacggcgcgc gtccctgtag gcgcctcggt cggcatcgtc      600

ggcctcggcg gggtgggact cgccgcgctg ctcggcgcgg tggcttcgtc cgcccggcac      660

atcgcggcca tcgacgtgaa ccccgagaaa ctggcgttcg cgcgcgaact cggcgcaacg      720

cacacgtacg acgcgcgcga tcccggcgtg attgacaagg tgcgcgcgga ttcggcgggc      780

ggcttggagt acgtgttcga gacggcgggc tccgtcgcgg ccatgaagac ggcgttcatg      840

gtgacgcggc gcggcggcac gaccgtgacc acagggctgc cggatcctcg gcacgagtgg      900

agcgtgcccc aggtgctgct tgcggccgag gagcgcacca ttcggggctc gtacgtcgga      960

agctgcatcc cgtcccgcga catcccgcgc ttcatttcct tgtttcagca agggaagctc     1020

cctgtcgacc ggctcgtgtc ggacgtgatc gatctcgacc acatcaacga gggcttcgac     1080

cgcctggctg cgggtgaggc ggtgcgcatc gtggtgcgaa tgagtggtgc ctaa           1134


<210>   1003
<211>   1134
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 988

<400>   1003
gtgcagacgc gagccgctgt cctcatggag atgggggcga ggccgcctta tgcatccaca       60

aggccgcttc gcctggagac gctggaactg gaaccgccag ggccgggcga ggtcctcatc      120

cgggtgcgcg ccgccggcct gtgtcattcg gatctgtccg tcattgaggg cgcccgcccg      180

cggccgatgc cgatggccct tggccacgag gcggctggcg aggtggtgga gctcggcgaa      240

ggagtgacgg acctcgcgcc gggcgatcac gtcgtctgcg cctttgtgcc aagctgcggg      300

cactgcgccc cctgtcaaga gggccggcca gcgctctgcg agccgggcgc cgaggccaac      360

ggccgcggca cgctgctctc cggcgcgcgc aggctgcgcc ttggcggaca gcccgtccat      420

caccacctcg gcgtgtcggc cttcagcgac tacgccgtcg tctcgcgccg ctcgctggtg      480

agaatcgatc cgtccctccc gttcgagcac gcggcgctgt ttggctgcgc ggtcatgacg      540

ggcgtcggcg cgatcgtcaa cacggcgcgc gtccctgtag gcgcctcggt cggcatcgtc      600

ggcctcggcg gggtgggact cgccgcgctg ctcggcgcgg tggcttcgtc cgcccggcac      660

atcgcggcca tcgacgtgaa ccccgagaaa ctggcgttcg cgcgcgaact cggcgcaacg      720

cacacgtacg acgcgcgcga tcccggcgtg attgacaagg tgcgcgcgga ttcggcgggc      780

ggcttggagt acgtgttcga gacggcgggc tccgtcgcgg ccatgaagac ggcgttcatg      840

gtgacgcggc gcggcggcac gaccgtgacc acagggctgc cggatcctcg gcacgagtgg      900

agcgtgcccc aggtgctgct tgcggccgag gagcgcacca ttcggggctc gtacgtcgga      960

agctgcatcc cgtcccgcga catcccgcgc ttcatttcct tgtttcagca agggaagctc     1020

cctgtcgacc ggctcgtgtc ggacgtgtta gatctcgacc acatcaacga gggcttcgac     1080

cgcctggctg cgggtgaggc ggtgcgcatc gtggtgcgaa tgagtggtgc ctaa           1134


<210>   1004
<211>   213
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1004
Met Leu Thr Val Ala Met Ala Lys Gly Arg Thr Leu Asp Asp Val Val 
                5                   10                  15      

Pro Leu Trp Glu Glu Ala Gly Ile Pro Tyr Pro Arg Asp Trp Asp Glu 
            20                  25                  30          

Ser Arg Ala Leu Val Phe Glu Ile Pro Trp Arg Asp Trp Thr Leu Arg 
        35                  40                  45              

Tyr Leu Leu Ala Lys Pro Ala Asp Val Pro Thr Tyr Val Ala Tyr Gly 
    50                  55                  60                  

Val Ala Asp Leu Gly Ile Val Gly Asn Asp Ile Leu Leu Glu Gln Glu 
65                  70                  75                  80  

Arg Glu Met Tyr Glu Leu Leu Asp Leu Gly Val Ala Arg Cys Lys Leu 
                85                  90                  95      

Cys Val Ala Gly Arg Glu Glu Glu Arg Arg His Ala Pro Arg Arg Val 
            100                 105                 110         

Ala Thr Lys Tyr Pro Lys Leu Ala Asp Arg Tyr Phe Arg Ser Gln Gly 
        115                 120                 125             

His Gln Val Glu Ile Val Pro Leu Ala Gly Ser Ile Glu Leu Ala Ser 
    130                 135                 140                 

Val Ile Gly Leu Thr Asp Arg Ile Phe Asp Leu Val Gln Thr Gly Glu 
145                 150                 155                 160 

Thr Leu Arg Ala Asn Gly Leu Val Val Phe Asp Glu Val Leu Asp Ile 
                165                 170                 175     

Ser Ala Arg Leu Val Ala Asn Arg Ser Ser Tyr Arg Met Lys His Arg 
            180                 185                 190         

Glu Ile Ser Ala Cys Leu Glu Arg Leu Glu Ala Ala Val Ala Arg Arg 
        195                 200                 205             

Asn Ala Tyr Ala Pro 
    210             

<210>   1005
<211>   642
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1005
atgttgaccg tggcgatggc caaggggcgc acgctggacg acgtggtgcc gctctgggaa       60

gaggccggca tcccgtatcc gcgcgactgg gacgagagcc gcgcgctcgt gttcgagatc      120

ccttggcgag actggaccct gcggtacctc ctcgccaagc cggccgacgt gcccacgtac      180

gtcgcctacg gtgtggccga tctcggcatt gtcggcaacg acatcctgct cgaacaggag      240

cgggagatgt acgagctgct cgatctcggc gtcgcgcgct gcaagctctg cgtcgccggg      300

cgcgaagagg agcgccgcca cgcgccgcgc cgcgtggcga ccaaataccc gaagctcgcc      360

gaccggtact ttcgcagcca ggggcaccag gtggagattg tgccgctcgc ggggtccatc      420

gagctcgcca gcgtgattgg cctgacggat cgcatcttcg atctcgtcca gaccggcgag      480

acgctccggg ccaacgggct cgtggtgttc gacgaggtgc tcgacatctc cgcgaggctc      540

gtggccaacc gatccagcta ccggatgaag caccgagaaa tctcggcctg cctggagcgc      600

ctggaggcgg ccgtcgcgag gaggaacgcg tatgcgcctt ga                         642


<210>   1006
<211>   204
<212>   PRT
<213>   Bacillus sp. SG-1

<400>   1006
Leu Thr Ile Ala Met Pro Lys Gly Arg Ile Phe Asp Glu Ala Leu Glu 
                5                   10                  15      

Leu Leu Arg Gln Ala Gly Tyr Asn Leu Pro Pro Glu Phe Asp Asp Ser 
            20                  25                  30          

Arg Lys Leu Ile Ile Glu Val Pro Glu Glu Lys Leu Thr Phe Ile Leu 
        35                  40                  45              

Ala Lys Pro Met Asp Val Pro Thr Tyr Val Glu His Gly Val Ala Asp 
    50                  55                  60                  

Leu Gly Ile Ala Gly Lys Asp Val Met Leu Glu Glu Glu Arg Asp Val 
65                  70                  75                  80  

Tyr Glu Leu Leu Asp Leu Lys Ile Ser Ala Cys Tyr Leu Ala Val Ala 
                85                  90                  95      

Gly Leu Pro Gly Thr Lys Met Asn Glu Val Ala Pro Lys Ile Ala Thr 
            100                 105                 110         

Lys Tyr Pro Thr Ile Ala Ser Ser Tyr Phe Arg Glu Gln Gly Glu Gln 
        115                 120                 125             

Val Glu Ile Ile Lys Leu Asn Gly Ser Ile Glu Leu Ala Pro Met Ile 
    130                 135                 140                 

Gly Leu Ala Asp Arg Ile Val Asp Ile Val Ser Thr Gly Arg Thr Leu 
145                 150                 155                 160 

Lys Glu Asn Gly Leu Val Glu Tyr Glu Lys Ile Val Asp Ile Thr Ser 
                165                 170                 175     

Arg Leu Ile Val Asn Pro Val Ser Tyr Arg Met Lys Asp Glu Arg Ile 
            180                 185                 190         

Asp Glu Leu Ala Glu Arg Leu Arg Glu Val Val Ser 
        195                 200                 

<210>   1007
<211>   201
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1007
Met Leu Thr Val Ala Met Pro Lys Gly Arg Ile Phe Asp Glu Ala Val 
                5                   10                  15      

Gly Leu Leu Arg Lys Ala Gly Tyr Asn Leu Pro Ala Glu Phe Glu Ala 
            20                  25                  30          

Ser Arg Lys Leu Ile Val Asp Val Pro Glu Glu Asn Met Arg Phe Ile 
        35                  40                  45              

Leu Ala Lys Pro Met Asp Val Pro Thr Tyr Val Glu His Gly Val Ala 
    50                  55                  60                  

Asp Val Gly Val Ala Gly Lys Asp Val Met Leu Glu Glu Glu Arg Asp 
65                  70                  75                  80  

Val Tyr Glu Val Leu Asp Leu Lys Ile Ser Glu Cys Tyr Leu Ala Val 
                85                  90                  95      

Ala Gly Leu Pro Asn Tyr Glu Lys Lys His Asp Leu Asn Pro Lys Val 
            100                 105                 110         

Ala Ser Lys Tyr Pro His Leu Ala Thr Arg Tyr Phe Lys Glu Gln Gly 
        115                 120                 125             

Glu Gln Val Glu Ile Ile Lys Leu Asn Gly Ser Ile Glu Leu Ala Pro 
    130                 135                 140                 

Leu Ile Gly Leu Ala Asp Arg Ile Val Asp Ile Val Ser Thr Gly Arg 
145                 150                 155                 160 

Thr Leu Arg Glu Asn Gly Leu Val Glu Leu Glu Lys Met Met Thr Ile 
                165                 170                 175     

Thr Ser Arg Leu Ile Val Asn Pro Val Ser Tyr Arg Met Lys Asp Glu 
            180                 185                 190         

Arg Ile Asp Glu Met Val Glu Arg Leu 
        195                 200     

<210>   1008
<211>   204
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1008
Met Leu Thr Ile Ala Met Pro Lys Gly Arg Ile Phe Glu Glu Ala Val 
                5                   10                  15      

Glu Leu Leu Arg Arg Ala Asp Tyr Ala Leu Pro Pro Glu Phe Thr Glu 
            20                  25                  30          

Ser Arg Lys Leu Val Ile Asp Val Pro Glu Glu Asn Met Arg Phe Ile 
        35                  40                  45              

Leu Ala Lys Pro Met Asp Val Val Thr Tyr Val Glu His Gly Val Ala 
    50                  55                  60                  

Asp Leu Gly Ile Ala Gly Lys Asp Val Leu Met Glu Glu Glu Arg Asp 
65                  70                  75                  80  

Val Tyr Glu Leu Leu Asp Leu His Ile Ser Arg Cys His Leu Ala Val 
                85                  90                  95      

Ala Gly Met Pro Gly Ala Lys Met Asn Glu Ile Ala Pro Arg Val Ala 
            100                 105                 110         

Thr Lys Tyr Pro Asn Ile Ala Ser Thr Tyr Phe Arg Glu Gln Gly Glu 
        115                 120                 125             

Gln Val Glu Ile Ile Arg Leu Asn Gly Ser Ile Glu Leu Ala Pro Leu 
    130                 135                 140                 

Ile Gly Leu Ala Asp Arg Ile Val Asp Ile Val Ser Thr Gly Arg Thr 
145                 150                 155                 160 

Leu Arg Glu Asn Gly Leu Val Glu Leu Glu Arg Ile Ala Glu Val Thr 
                165                 170                 175     

Ser Arg Leu Ile Val Asn Pro Ala Ser Tyr Arg Leu Asn Gly Gly Asp 
            180                 185                 190         

Ile Glu Arg Leu Val Asp Arg Leu Ala Ala Val Ile 
        195                 200                 

<210>   1009
<211>   208
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1009
Leu Thr Ile Ala Met Pro Lys Gly Arg Ile Phe Glu Glu Ala Ala Asp 
                5                   10                  15      

Met Leu Arg Lys Ala Gly Tyr Gln Leu Pro Glu Glu Phe Asp Asp Ser 
            20                  25                  30          

Arg Lys Leu Ile Ile Gln Val Pro Glu Glu Asn Leu Arg Phe Ile Leu 
        35                  40                  45              

Ala Lys Pro Met Asp Val Thr Thr Tyr Val Glu His Gly Val Ala Asp 
    50                  55                  60                  

Val Gly Ile Ala Gly Lys Asp Val Leu Leu Glu Glu Glu Arg Asp Val 
65                  70                  75                  80  

Tyr Glu Val Leu Asp Leu Asn Ile Ser Lys Cys Arg Leu Ala Val Ala 
                85                  90                  95      

Gly Leu Pro Glu Thr Ala Ala Asp Thr Val Ala Pro Arg Val Ala Thr 
            100                 105                 110         

Lys Tyr Pro Asn Val Ala Ser Ser Tyr Phe Arg Glu Gln Gly Glu Gln 
        115                 120                 125             

Val Glu Ile Ile Lys Leu Asn Gly Ser Ile Glu Leu Ala Pro Leu Ile 
    130                 135                 140                 

Gly Leu Ala Gly Arg Ile Val Asp Ile Val Ser Thr Gly Gln Thr Leu 
145                 150                 155                 160 

Arg Glu Asn Gly Leu Val Glu Thr Glu Lys Ile Cys Asp Ile Thr Ser 
                165                 170                 175     

Arg Leu Ile Val Asn Pro Val Ser Tyr Arg Met Lys Asp Ala Val Ile 
            180                 185                 190         

Asp Glu Met Ala Ser Arg Leu Ser Leu Ile Val Glu Gly Glu Lys Ala 
        195                 200                 205             

<210>   1010
<211>   209
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   1010
Leu Leu Thr Ile Ala Met Pro Lys Gly Arg Ile Phe Glu Glu Ala Ala 
                5                   10                  15      

Glu Leu Leu Arg Gln Ala Gly Phe Asp Leu Pro Pro Glu Phe Asp Asp 
            20                  25                  30          

Ser Arg Lys Leu Ile Ile Asp Val Glu Glu Glu Arg Phe Gln Phe Ile 
        35                  40                  45              

Leu Ala Lys Pro Met Asp Val Pro Thr Tyr Val Glu His Gly Val Ala 
    50                  55                  60                  

Asp Leu Gly Ile Ala Gly Lys Asp Val Met Leu Glu Glu Glu Arg Asp 
65                  70                  75                  80  

Ile Tyr Glu Leu Leu Asp Leu Lys Ile Ser Ala Cys Tyr Leu Ala Val 
                85                  90                  95      

Ala Gly Ile Pro Gly Thr Lys Met Asn Glu Val Ala Pro Lys Val Ala 
            100                 105                 110         

Thr Lys Tyr Pro Asn Val Ala Ala Ala Tyr Phe Arg Glu Gln Gly Glu 
        115                 120                 125             

Gln Val Glu Ile Ile Lys Leu Asn Gly Ser Ile Glu Leu Ala Pro Leu 
    130                 135                 140                 

Ile Gly Leu Ser Asp Arg Ile Val Asp Ile Val Ser Thr Gly Arg Thr 
145                 150                 155                 160 

Leu Lys Glu Asn Gly Leu Val Glu Tyr Glu Gln Ile Val Gly Ile Thr 
                165                 170                 175     

Ser Arg Leu Ile Val Asn Pro Val Ser Tyr Arg Ile Lys Asp Lys Arg 
            180                 185                 190         

Ile Ser Glu Ile Val Asp Lys Leu Ser Arg Val Val Asn Glu Gln Ala 
        195                 200                 205             

Ala 
    

<210>   1011
<211>   213
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1004

<400>   1011
Met Leu Thr Val Ala Met Ala Lys Gly Arg Thr Leu Asp Asp Val Val 
                5                   10                  15      

Pro Leu Trp Glu Glu Ala Gly Ile Pro Tyr Pro Arg Asp Trp Asp Glu 
            20                  25                  30          

Ser Arg Ala Leu Val Phe Glu Ile Pro Trp Arg Asp Trp Thr Leu Arg 
        35                  40                  45              

Tyr Leu Leu Ala Lys Pro Ala Asp Val Pro Thr Tyr Val Ala Tyr Gly 
    50                  55                  60                  

Val Ala Asp Leu Gly Ile Val Gly Asn Asp Ile Leu Leu Glu Gln Glu 
65                  70                  75                  80  

Arg Glu Met Tyr Glu Leu Leu Asp Leu Gly Val Ala Arg Cys Lys Leu 
                85                  90                  95      

Cys Val Ala Gly Arg Glu Glu Glu Arg Arg His Ala Pro Arg Arg Val 
            100                 105                 110         

Ala Thr Lys Tyr Pro Lys Leu Ala Asp Arg Tyr Phe Arg Ser Gln Gly 
        115                 120                 125             

His Gln Val Glu Ile Val Pro Leu Ala Gly Ser Ile Glu Leu Ala Ser 
    130                 135                 140                 

Val Ile Gly Leu Thr Asp Arg Ile Phe Asp Leu Val Gln Thr Gly Glu 
145                 150                 155                 160 

Thr Leu Arg Ala Asn Gly Leu Val Ile Phe Asp Glu Val Leu Asp Ile 
                165                 170                 175     

Ser Ala Arg Leu Val Ala Asn Arg Ser Ser Tyr Arg Met Lys His Arg 
            180                 185                 190         

Glu Ile Ser Ala Cys Leu Glu Arg Leu Glu Ala Ala Val Ala Arg Arg 
        195                 200                 205             

Asn Ala Tyr Ala Pro 
    210             

<210>   1012
<211>   213
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1004

<400>   1012
Met Leu Thr Val Ala Met Ala Lys Gly Arg Thr Leu Asp Asp Val Val 
                5                   10                  15      

Pro Leu Trp Glu Glu Ala Gly Ile Pro Tyr Pro Arg Asp Trp Asp Glu 
            20                  25                  30          

Ser Arg Ala Leu Val Phe Glu Ile Pro Trp Arg Asp Trp Thr Leu Arg 
        35                  40                  45              

Tyr Leu Leu Ala Lys Pro Ala Asp Val Pro Thr Tyr Val Ala Tyr Gly 
    50                  55                  60                  

Val Ala Asp Leu Gly Ile Val Gly Asn Asp Ile Leu Leu Glu Gln Glu 
65                  70                  75                  80  

Arg Glu Met Tyr Glu Leu Leu Asp Leu Gly Val Ala Arg Cys Lys Leu 
                85                  90                  95      

Cys Val Ala Gly Arg Glu Glu Glu Arg Arg His Ala Pro Arg Arg Val 
            100                 105                 110         

Ala Thr Lys Tyr Pro Arg Leu Ala Asp Arg Tyr Phe Arg Ser Gln Gly 
        115                 120                 125             

His Gln Val Glu Ile Val Pro Leu Ala Gly Ser Ile Glu Leu Ala Ser 
    130                 135                 140                 

Val Ile Gly Leu Thr Asp Arg Ile Phe Asp Leu Val Gln Thr Gly Glu 
145                 150                 155                 160 

Thr Leu Arg Ala Asn Gly Leu Val Val Phe Asp Glu Val Leu Asp Ile 
                165                 170                 175     

Ser Ala Arg Leu Val Ala Asn Arg Ser Ser Tyr Arg Met Lys His Arg 
            180                 185                 190         

Glu Ile Ser Ala Cys Leu Glu Arg Leu Glu Ala Ala Val Ala Arg Arg 
        195                 200                 205             

Asn Ala Tyr Ala Pro 
    210             

<210>   1013
<211>   213
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1004

<400>   1013
Met Leu Thr Val Ala Met Ala Lys Gly Arg Thr Leu Asp Asp Val Ile 
                5                   10                  15      

Pro Leu Trp Glu Glu Ala Gly Ile Pro Tyr Pro Arg Asp Trp Asp Glu 
            20                  25                  30          

Ser Arg Ala Leu Val Phe Glu Ile Pro Trp Arg Asp Trp Thr Leu Arg 
        35                  40                  45              

Tyr Leu Leu Ala Lys Pro Ala Asp Val Pro Thr Tyr Val Ala Tyr Gly 
    50                  55                  60                  

Val Ala Asp Leu Gly Ile Val Gly Asn Asp Ile Leu Leu Glu Gln Glu 
65                  70                  75                  80  

Arg Glu Met Tyr Glu Leu Leu Asp Leu Gly Val Ala Arg Cys Lys Leu 
                85                  90                  95      

Cys Val Ala Gly Arg Glu Glu Glu Arg Arg His Ala Pro Arg Arg Val 
            100                 105                 110         

Ala Thr Lys Tyr Pro Lys Leu Ala Asp Arg Tyr Phe Arg Ser Gln Gly 
        115                 120                 125             

His Gln Val Glu Ile Val Pro Leu Ala Gly Ser Ile Glu Leu Ala Ser 
    130                 135                 140                 

Val Ile Gly Leu Thr Asp Arg Ile Phe Asp Leu Val Gln Thr Gly Glu 
145                 150                 155                 160 

Thr Leu Arg Ala Asn Gly Leu Val Val Phe Asp Glu Val Leu Asp Ile 
                165                 170                 175     

Ser Ala Arg Leu Val Ala Asn Arg Ser Ser Tyr Arg Met Lys His Arg 
            180                 185                 190         

Glu Ile Ser Ala Cys Leu Glu Arg Leu Glu Ala Ala Val Ala Arg Arg 
        195                 200                 205             

Asn Ala Tyr Ala Pro 
    210             

<210>   1014
<211>   213
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1004

<400>   1014
Met Leu Thr Val Ala Met Ala Lys Gly Arg Thr Leu Asp Asp Val Val 
                5                   10                  15      

Pro Leu Trp Glu Glu Ala Gly Ile Pro Tyr Pro Arg Asp Trp Asp Glu 
            20                  25                  30          

Ser Arg Ala Leu Val Phe Glu Ile Pro Trp Arg Asp Trp Thr Leu Arg 
        35                  40                  45              

Tyr Leu Leu Ala Lys Pro Ala Asp Val Pro Thr Tyr Val Ala Tyr Gly 
    50                  55                  60                  

Val Ala Asp Leu Gly Ile Val Gly Asn Asp Ile Leu Leu Glu Gln Glu 
65                  70                  75                  80  

Arg Glu Met Tyr Glu Leu Leu Asp Leu Gly Val Ala Arg Cys Lys Leu 
                85                  90                  95      

Cys Val Ala Gly Arg Glu Glu Glu Arg Arg His Ala Pro Arg Arg Val 
            100                 105                 110         

Ala Thr Lys Tyr Pro Lys Leu Ala Asp Arg Tyr Phe Arg Ser Gln Gly 
        115                 120                 125             

His Gln Val Glu Ile Val Pro Leu Ala Gly Ser Ile Glu Leu Ala Ser 
    130                 135                 140                 

Val Ile Gly Leu Thr Asp Arg Ile Phe Asp Leu Val Gln Thr Gly Glu 
145                 150                 155                 160 

Thr Leu Arg Ala Asn Gly Leu Val Val Phe Asp Glu Val Leu Asp Ile 
                165                 170                 175     

Ser Ala Arg Leu Val Ala Asn Arg Ser Ser Tyr Arg Met Lys His Arg 
            180                 185                 190         

Glu Ile Ser Ala Cys Ile Glu Arg Leu Glu Ala Ala Val Ala Arg Arg 
        195                 200                 205             

Asn Ala Tyr Ala Pro 
    210             

<210>   1015
<211>   213
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1004

<400>   1015
Met Leu Thr Val Ala Met Ala Lys Gly Arg Thr Leu Asp Asp Val Val 
                5                   10                  15      

Pro Leu Trp Glu Glu Ala Gly Ile Pro Tyr Pro Arg Asp Trp Asp Glu 
            20                  25                  30          

Ser Arg Ala Leu Val Phe Glu Ile Pro Trp Arg Asp Trp Thr Leu Arg 
        35                  40                  45              

Tyr Leu Leu Ala Lys Pro Ala Asp Val Pro Thr Tyr Val Ala Tyr Gly 
    50                  55                  60                  

Val Ala Asp Leu Gly Ile Val Gly Asn Asp Ile Leu Leu Glu Gln Glu 
65                  70                  75                  80  

Arg Glu Met Tyr Glu Leu Leu Asp Leu Gly Val Ala Arg Cys Lys Leu 
                85                  90                  95      

Cys Val Ala Gly Arg Glu Glu Glu Arg Arg His Ala Pro Arg Arg Val 
            100                 105                 110         

Ala Thr Lys Tyr Pro Lys Leu Ala Asp Arg Tyr Phe Arg Ser Gln Gly 
        115                 120                 125             

His Gln Val Glu Ile Val Pro Leu Ala Gly Ser Ile Glu Leu Ala Ser 
    130                 135                 140                 

Val Ile Gly Leu Thr Asp Arg Ile Phe Asp Leu Val Gln Thr Gly Glu 
145                 150                 155                 160 

Thr Leu Arg Ala Asn Gly Leu Val Val Phe Asp Glu Val Leu Asp Ile 
                165                 170                 175     

Ser Ala Arg Leu Val Ala Asn Lys Ser Ser Tyr Arg Met Lys His Arg 
            180                 185                 190         

Glu Ile Ser Ala Cys Leu Glu Arg Leu Glu Ala Ala Val Ala Arg Arg 
        195                 200                 205             

Asn Ala Tyr Ala Pro 
    210             

<210>   1016
<211>   642
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1005

<400>   1016
atgttgaccg tggcgatggc caaggggcgc acgctggacg acgtggtgcc gctctgggaa       60

gaggccggca tcccgtatcc gcgcgactgg gacgagagcc gcgcgctcgt gttcgagatc      120

ccttggcgag actggaccct gcggtacctc ctcgccaagc cggccgacgt gcccacgtac      180

gtcgcctacg gtgtggccga tctcggcatt gtcggcaacg acatcctgct cgaacaggag      240

cgggagatgt acgagctgct cgatctcggc gtcgcgcgct gcaagctctg cgtcgccggg      300

cgcgaagagg agcgccgcca cgcgccgcgc cgcgtggcga ccaaataccc gaagctcgcc      360

gaccggtact ttcgcagcca ggggcaccag gtggagattg tgccgctcgc ggggtccatc      420

gagctcgcca gcgtgattgg cctgacggat cgcatcttcg atctcgtcca gaccggcgag      480

acgctccggg ccaacgggct cgtgattttc gacgaggtgc tcgacatctc cgcgaggctc      540

gtggccaacc gatccagcta ccggatgaag caccgagaaa tctcggcctg cctggagcgc      600

ctggaggcgg ccgtcgcgag gaggaacgcg tatgcgcctt ga                         642


<210>   1017
<211>   642
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1005

<400>   1017
atgttgaccg tggcgatggc caaggggcgc acgctggacg acgtggtgcc gctctgggaa       60

gaggccggca tcccgtatcc gcgcgactgg gacgagagcc gcgcgctcgt gttcgagatc      120

ccttggcgag actggaccct gcggtacctc ctcgccaagc cggccgacgt gcccacgtac      180

gtcgcctacg gtgtggccga tctcggcatt gtcggcaacg acatcctgct cgaacaggag      240

cgggagatgt acgagctgct cgatctcggc gtcgcgcgct gcaagctctg cgtcgccggg      300

cgcgaagagg agcgccgcca cgcgccgcgc cgcgtggcga ccaaataccc gcgtctcgcc      360

gaccggtact ttcgcagcca ggggcaccag gtggagattg tgccgctcgc ggggtccatc      420

gagctcgcca gcgtgattgg cctgacggat cgcatcttcg atctcgtcca gaccggcgag      480

acgctccggg ccaacgggct cgtggtgttc gacgaggtgc tcgacatctc cgcgaggctc      540

gtggccaacc gatccagcta ccggatgaag caccgagaaa tctcggcctg cctggagcgc      600

ctggaggcgg ccgtcgcgag gaggaacgcg tatgcgcctt ga                         642


<210>   1018
<211>   642
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1005

<400>   1018
atgttgaccg tggcgatggc caaggggcgc acgctggacg acgtgattcc gctctgggaa       60

gaggccggca tcccgtatcc gcgcgactgg gacgagagcc gcgcgctcgt gttcgagatc      120

ccttggcgag actggaccct gcggtacctc ctcgccaagc cggccgacgt gcccacgtac      180

gtcgcctacg gtgtggccga tctcggcatt gtcggcaacg acatcctgct cgaacaggag      240

cgggagatgt acgagctgct cgatctcggc gtcgcgcgct gcaagctctg cgtcgccggg      300

cgcgaagagg agcgccgcca cgcgccgcgc cgcgtggcga ccaaataccc gaagctcgcc      360

gaccggtact ttcgcagcca ggggcaccag gtggagattg tgccgctcgc ggggtccatc      420

gagctcgcca gcgtgattgg cctgacggat cgcatcttcg atctcgtcca gaccggcgag      480

acgctccggg ccaacgggct cgtggtgttc gacgaggtgc tcgacatctc cgcgaggctc      540

gtggccaacc gatccagcta ccggatgaag caccgagaaa tctcggcctg cctggagcgc      600

ctggaggcgg ccgtcgcgag gaggaacgcg tatgcgcctt ga                         642


<210>   1019
<211>   642
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1005

<400>   1019
atgttgaccg tggcgatggc caaggggcgc acgctggacg acgtggtgcc gctctgggaa       60

gaggccggca tcccgtatcc gcgcgactgg gacgagagcc gcgcgctcgt gttcgagatc      120

ccttggcgag actggaccct gcggtacctc ctcgccaagc cggccgacgt gcccacgtac      180

gtcgcctacg gtgtggccga tctcggcatt gtcggcaacg acatcctgct cgaacaggag      240

cgggagatgt acgagctgct cgatctcggc gtcgcgcgct gcaagctctg cgtcgccggg      300

cgcgaagagg agcgccgcca cgcgccgcgc cgcgtggcga ccaaataccc gaagctcgcc      360

gaccggtact ttcgcagcca ggggcaccag gtggagattg tgccgctcgc ggggtccatc      420

gagctcgcca gcgtgattgg cctgacggat cgcatcttcg atctcgtcca gaccggcgag      480

acgctccggg ccaacgggct cgtggtgttc gacgaggtgc tcgacatctc cgcgaggctc      540

gtggccaacc gatccagcta ccggatgaag caccgagaaa tctcggcctg cattgagcgc      600

ctggaggcgg ccgtcgcgag gaggaacgcg tatgcgcctt ga                         642


<210>   1020
<211>   642
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1005

<400>   1020
atgttgaccg tggcgatggc caaggggcgc acgctggacg acgtggtgcc gctctgggaa       60

gaggccggca tcccgtatcc gcgcgactgg gacgagagcc gcgcgctcgt gttcgagatc      120

ccttggcgag actggaccct gcggtacctc ctcgccaagc cggccgacgt gcccacgtac      180

gtcgcctacg gtgtggccga tctcggcatt gtcggcaacg acatcctgct cgaacaggag      240

cgggagatgt acgagctgct cgatctcggc gtcgcgcgct gcaagctctg cgtcgccggg      300

cgcgaagagg agcgccgcca cgcgccgcgc cgcgtggcga ccaaataccc gaagctcgcc      360

gaccggtact ttcgcagcca ggggcaccag gtggagattg tgccgctcgc ggggtccatc      420

gagctcgcca gcgtgattgg cctgacggat cgcatcttcg atctcgtcca gaccggcgag      480

acgctccggg ccaacgggct cgtggtgttc gacgaggtgc tcgacatctc cgcgaggctc      540

gtggccaaca aatccagcta ccggatgaag caccgagaaa tctcggcctg cctggagcgc      600

ctggaggcgg ccgtcgcgag gaggaacgcg tatgcgcctt ga                         642


<210>   1021
<211>   398
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1021
Met Tyr Asp Ile Tyr Gly Glu Ala Ala Leu Pro Ala Asp Val Arg Glu 
                5                   10                  15      

Arg Leu Arg Ile Thr Arg Asp Leu Ala Gln Ala Phe His Glu Arg Ala 
            20                  25                  30          

Pro Glu His Asp Arg Ala Gly Asp Phe Pro Phe Glu Asn Ile Glu Asp 
        35                  40                  45              

Leu Lys Ala Ser Gly Tyr Val Arg Trp Thr Val Pro Val Glu Tyr Gly 
    50                  55                  60                  

Gly Leu Gly Leu Ser Leu Glu Glu Met Leu Met His Gln Glu Val Leu 
65                  70                  75                  80  

Ala Lys Gly Asp Gly Ser Thr Ala Leu Ala Ile Gly Trp His Val Gly 
                85                  90                  95      

Ile Leu Leu His Leu Arg Glu Thr Gly Ala Phe Pro Asp Glu Leu Phe 
            100                 105                 110         

Arg Met Val Cys Glu Ser Val Val Lys Glu Gly Ala Leu Ile Asn Ser 
        115                 120                 125             

Cys Ala Thr Glu Pro Ala Thr Gly Ser Pro Ser Arg Gly Gly Lys Pro 
    130                 135                 140                 

Glu Thr Thr Ala Val Lys Val Pro Gly Gly Tyr Arg Ile Thr Gly Arg 
145                 150                 155                 160 

Lys Thr Phe Ser Thr Leu Ser Pro Ala Leu Thr Trp Ile Met Val Thr 
                165                 170                 175     

Ala Thr Val Ala Asp Glu Asp Val Val Gly Gln Phe Leu Val Arg Lys 
            180                 185                 190         

Glu Asp Val Glu Ile Val Glu Thr Trp Asp Thr Leu Gly Met Arg Ala 
        195                 200                 205             

Thr Gly Ser His Asp Ile Val Leu Lys Asp Val Phe Val Pro Glu Glu 
    210                 215                 220                 

Arg Val Ile Val Ile Gln Arg Pro Gly Val Gln Ala Glu Arg Arg Pro 
225                 230                 235                 240 

Asp Gly Ser Gly Trp Leu Leu His Ile Pro Ala Cys Tyr Leu Gly Ile 
                245                 250                 255     

Ala Leu Ala Ala Arg Asp Phe Ala Leu Glu Tyr Ala Ala Thr Tyr Arg 
            260                 265                 270         

Pro Asn Thr Leu Pro His Pro Ile Ala Glu Val Pro His Val Glu Gln 
        275                 280                 285             

Lys Leu Gly Glu Met Glu Leu Lys Leu Leu Ala Ala Arg Thr Leu Leu 
    290                 295                 300                 

Tyr Asp Leu Ala Arg Arg Phe Asp Ala Ala Ser Pro Glu Glu Arg Val 
305                 310                 315                 320 

Lys Leu Gln Pro Gln Phe Gly Ala Val Lys Thr Leu Ala Thr Asn Ala 
                325                 330                 335     

Ala Asn Gln Val Val Asp Leu Ala Met Arg Val Val Gly Gly Arg Ser 
            340                 345                 350         

Leu Ser Arg Ala Leu Pro Leu Glu Arg Tyr Tyr Arg Asp Val Arg Ala 
        355                 360                 365             

Gly Leu His Asn Pro Pro Met Asp Asp Val Val Tyr Arg Asn Leu Ala 
    370                 375                 380                 

Lys Ala Ala Leu Ala Arg Arg Ala Ala Gly Gln Ala Gly Arg 
385                 390                 395             

<210>   1022
<211>   1197
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1022
atgtacgaca tctatggaga agccgcactg cccgcggacg tgcgcgagcg cctgcgcatc       60

acgcgcgatc tcgcccaagc cttccacgag cgcgcgcccg agcacgatcg cgcgggcgac      120

tttccgtttg agaacatcga ggatttgaag gcgtcgggtt acgtgcgctg gacggtgccc      180

gtggaatacg gggggctcgg cctaagcctc gaggagatgc tcatgcatca ggaggtgctg      240

gcgaaaggcg acggatcgac cgcgctcgcg attggctggc acgtgggcat tctgcttcac      300

ctgcgcgaga cgggggcgtt cccggatgag ctgtttcgca tggtgtgcga gtccgtcgtg      360

aaggagggcg cgctcatcaa cagctgcgcc acggagcccg ccacggggag cccgagccgc      420

ggcggcaagc cggagaccac cgccgtgaaa gtgcccggcg ggtatcggat cacgggccgc      480

aagacattca gcacgctctc gcctgcgctc acctggatca tggtgaccgc caccgtggcg      540

gacgaggacg tggtggggca gtttctcgtt cgaaaagagg acgtcgagat cgtcgagacg      600

tgggacacgc tcggcatgcg cgccaccggc agccacgaca ttgtgctgaa ggatgtgttt      660

gtgccggagg agcgggtgat tgtcatccag cgcccgggcg tgcaggccga gcgacggccg      720

gacgggagcg gttggctgct ccacattccg gcgtgttatc tcggcatcgc cctcgcggcg      780

cgcgactttg cgctggagta cgccgcgacg taccggccca acacgttgcc gcatcccatc      840

gcggaggttc cgcacgtcga gcagaaactc ggcgagatgg agctgaagct gctcgccgcc      900

cgcacgctcc tgtacgatct cgcccgccgc ttcgacgccg cctcgccgga ggaacgcgtc      960

aagctgcaac cccagttcgg cgcggtgaag acgctcgcga cgaatgccgc caatcaggtg     1020

gtggatctcg ccatgcgggt cgtcggcggc cgcagcctgt cgcgcgccct gcccctcgag     1080

cggtactacc gcgacgtccg cgccggcctg cacaatccgc cgatggacga cgtggtctac     1140

cgcaacctgg cgaaggccgc gctcgcgcgc cgcgccgcgg ggcaggcggg gaggtga        1197


<210>   1023
<211>   367
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   1023
Arg Arg Phe Val Ala Leu Ala Gly Glu Leu Ala Asp Arg Phe Ala Gly 
                5                   10                  15      

Arg Ala Ala Leu His Asp Arg Glu Asn Ser Phe Pro Phe Glu Asn Phe 
            20                  25                  30          

Ala Glu Leu Arg Ala Ser Gly Tyr Val Arg Leu Thr Val Pro Val Glu 
        35                  40                  45              

Trp Gly Gly Glu Gly Ala Asn Leu Thr Glu Thr Leu Leu Ala Gln Glu 
    50                  55                  60                  

Arg Leu Ala Gln Gly Asp Gly Ala Thr Ala Leu Gly Ile Gly Trp His 
65                  70                  75                  80  

Leu Ala Val Val Gly Lys Leu Ala Glu Thr Arg Ala Trp Pro Pro Ala 
                85                  90                  95      

Ala Thr Ala Arg Ile Phe Arg Glu Val Ala Gly Arg Gly Ala Leu Ile 
            100                 105                 110         

Asn Ser Ala Ala Ser Glu Val Glu Thr Gly Ser Pro Ser Arg Gly Gly 
        115                 120                 125             

Arg Pro Thr Thr Thr Ala Arg Arg Ala Pro Gly Gly Trp Leu Leu Thr 
    130                 135                 140                 

Gly Arg Lys Ser Phe Thr Ser Leu Ala Pro Val Leu Asp Tyr Ala Val 
145                 150                 155                 160 

Val Ser Ala Ser Phe Glu Gly Ser Asp Gly Gly Gly Trp Phe Leu Val 
                165                 170                 175     

Gln Thr Gly Ser Pro Gly Val Thr Val Val Glu Thr Trp Asp Ala Leu 
            180                 185                 190         

Gly Met Arg Ala Thr Gly Ser His Asp Leu Val Leu Glu Asp Val Phe 
        195                 200                 205             

Val Glu Asp Gly Asp Leu Leu Glu Thr Phe Gly Arg Gly Asn Thr Cys 
    210                 215                 220                 

Gln Val Gly Thr Gly Asp Gly Ala Gly Trp Ala Leu His Ile Pro Ala 
225                 230                 235                 240 

Val Tyr Leu Gly Ile Ala Arg Ala Ala His Gly Phe Ala Val Glu Tyr 
                245                 250                 255     

Ala Arg Thr Arg Arg Pro Asn Ser Leu Pro Gly Pro Ile Ala Asp Gln 
            260                 265                 270         

Pro His Ile Gln Ala Leu Leu Gly Gln Asn Glu Ile Asp Leu Leu Ala 
        275                 280                 285             

Ala Arg Ser Ala Leu Tyr Thr Val Ala Asp Arg Trp Asp Ala Glu Pro 
    290                 295                 300                 

Glu Arg Arg Gly Glu Leu Val Pro Leu Leu Gly Ala Ala Lys Val Leu 
305                 310                 315                 320 

Ala Val Asn Leu Ala Leu Gln Ile Val Asp Arg Ala Met Arg Val Ala 
                325                 330                 335     

Gly Ile Ala Gly Leu Phe Arg Gln Leu Pro Leu Glu Arg Leu Tyr Arg 
            340                 345                 350         

Asp Val Arg Ala Gly Leu His Asn Pro Pro Met Glu Asp Ala Val 
        355                 360                 365         

<210>   1024
<211>   360
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   1024
Lys Arg Ile Gln Leu Leu Lys Asn Thr Val Ala Pro Phe Asn Glu Arg 
                5                   10                  15      

Ala Gln Lys His Asp Lys Asp Val Ser Phe Pro Phe Glu Asn Tyr Lys 
            20                  25                  30          

Asp Leu Gln Ser Ile Gly Tyr Pro Ser Leu Thr Ile Pro Lys Glu Tyr 
        35                  40                  45              

Gly Gly Ala Gly Ile Thr Leu Asp Glu Leu Leu Thr Tyr Gln Glu Ile 
    50                  55                  60                  

Ile Ala Gln Ala Asp Gly Ser Thr Ala Leu Ser Ile Gly Trp His Met 
65                  70                  75                  80  

Gly Ile Met Lys Tyr Leu Gly Glu Asn Lys Ile Trp Asn Glu Asp Val 
                85                  90                  95      

Tyr Ser Thr Val Ala Asn Asp Val Ile Gln Asn Gly Ala Leu Leu Asn 
            100                 105                 110         

Asn Ala Ala Thr Glu Pro Ala Thr Gly Ser Pro Thr Arg Gly Gly Lys 
        115                 120                 125             

Pro Glu Thr His Ala Ile Lys Gln Gly Asn Lys Trp Ile Met Asn Gly 
    130                 135                 140                 

Arg Lys Thr Phe Thr Thr Leu Ser Pro Ile Leu Thr Tyr Phe Val Val 
145                 150                 155                 160 

Ser Ala Thr Ile Asp Glu Thr Gly Glu Val Gly Asn Phe Leu Ile Lys 
                165                 170                 175     

Arg Asp Arg Pro Gly Val Asn Val Glu Glu Thr Trp Asp Ser Ile Ala 
            180                 185                 190         

Met Arg Gly Ser Gly Ser His Asp Leu Val Leu Glu Asn Val His Leu 
        195                 200                 205             

Asp Glu Glu Asn Leu Val Glu Ile Leu Ser Asn Lys Lys Arg Lys Pro 
    210                 215                 220                 

Ala Gly Trp Leu Leu His Ile Pro Ala Cys Tyr Leu Gly Ile Ala Gln 
225                 230                 235                 240 

Ala Ala Gln Lys Glu Ala Val Gln Phe Ala Met Asn Tyr Ser Pro Asn 
                245                 250                 255     

Ser Ile Glu Gly Thr Ile Ser Asp Leu Pro Asn Val Lys Gln Lys Met 
            260                 265                 270         

Gly Asp Leu Glu Leu Leu Leu Met Glu Ser Lys His Phe Leu His Ser 
        275                 280                 285             

Ile Ala Gln Gln Trp Asp Asn Gly Asp Glu Asn Ile Arg Val Ala Met 
    290                 295                 300                 

Gly Pro Glu Leu Gly Ala Ala Lys Leu Ser Val Thr Asn Lys Ala Val 
305                 310                 315                 320 

His Ala Val Asp Leu Ala Met Arg Ile Val Gly Ala Lys Ser Leu Ser 
                325                 330                 335     

Glu Lys Asn Asn Leu Gln Arg Tyr Tyr Arg Asp Val Arg Ala Gly Leu 
            340                 345                 350         

His Asn Pro Pro Met Asp Asp Met 
        355                 360 

<210>   1025
<211>   364
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   1025
Lys Ala Ala Gly Glu Ala Asp Lys Tyr Glu Gln Met Lys Glu Leu Ser 
                5                   10                  15      

Ala Ile Phe Lys Glu Arg Ser Arg Ser Lys Glu Asn Arg Gly Ser Phe 
            20                  25                  30          

Pro His Arg Asn Ile Leu Asp Leu Lys Ala Ser Gly Tyr Thr Ser Leu 
        35                  40                  45              

Thr Val Pro Ala Asp Arg Gly Gly Lys Gly Ile Ser Leu Leu Glu Met 
    50                  55                  60                  

Ile Arg Leu Gln Glu Lys Leu Ala Glu Gly Asp Gly Ser Thr Ala Leu 
65                  70                  75                  80  

Ala Ile Gly Trp His Met Gly Ile Thr Lys Asn Leu Gly Glu Lys Arg 
                85                  90                  95      

Lys Trp Asp Asp Glu Leu Phe Ser Phe Leu Cys Arg Glu Ile Leu Asp 
            100                 105                 110         

Gly Lys Leu Ile Asn Ser Ala Ala Thr Glu Arg Gln Thr Gly Ser Pro 
        115                 120                 125             

Thr Arg Gly Gly Arg Pro Gln Thr Thr Ala Val Leu Lys Gly Gly Asn 
    130                 135                 140                 

Trp Val Ile Ser Gly Arg Lys Thr Phe Thr Thr Met Ala Pro Ala Leu 
145                 150                 155                 160 

Asp Tyr Phe Ile Val Ser Ala Phe Ile Pro Ser Glu Asp Lys Thr Gly 
                165                 170                 175     

Asn Phe Leu Val Pro Arg Glu Ala Glu Gly Leu Ser Ile Glu Glu Thr 
            180                 185                 190         

Trp Asp Ser Val Ser Met Arg Gly Thr Gly Ser His Asp Leu Val Leu 
        195                 200                 205             

Asp Glu Val Ser Ile Asp Lys Thr Phe Leu Ala Glu Ile Leu Gly Gln 
    210                 215                 220                 

Asp Lys Lys Ala Asn Gly Trp Leu Leu His Ile Pro Ala Val Tyr Leu 
225                 230                 235                 240 

Gly Ile Ala Gln Ala Ala Gln Asp Tyr Ala Ala Gly Phe Ala Lys Ser 
                245                 250                 255     

Tyr Ser Pro Asn Ser Ile Gln Gly Thr Ile Ser Asp Ile Pro Ser Val 
            260                 265                 270         

Gln Gln Lys Ile Gly Glu Ile Glu Leu Glu Leu Met Arg Ala Arg Glu 
        275                 280                 285             

Phe Leu Tyr Ala Ala Ala Asp Arg Trp Asp Arg Ala Ala Glu Asn Glu 
    290                 295                 300                 

Arg Glu Ser Met Gln Pro Leu Leu Gly Ala Val Lys Leu Ala Val Thr 
305                 310                 315                 320 

Asn Ala Ala Leu Thr Val Ala Asp Leu Ala Ile Arg Val Val Gly Ala 
                325                 330                 335     

Arg Ser Leu Ser Glu Gln Asn Pro Leu Gln Gln Tyr Tyr Leu Asp Ile 
            340                 345                 350         

Arg Ala Gly Leu His Asn Pro Pro Met Asp Asp Met 
        355                 360                 

<210>   1026
<211>   351
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   1026
Ile Ala Asp Glu Phe Gln Gln Thr Ala Ala Glu Asp Asp Glu Gln Gly 
                5                   10                  15      

Arg Phe Pro Ala Glu Lys Ile Gln Lys Leu Arg Asp Ala Gly Tyr Thr 
            20                  25                  30          

Ala Leu Thr Leu Pro Ala Ser His Gly Gly Gly Gly Ile Ser Val Tyr 
        35                  40                  45              

Asp Met Leu Leu Phe Gln Glu Arg Leu Ala Arg Gly Asp Ala Pro Thr 
    50                  55                  60                  

Ala Leu Ser Ile Gly Trp His Leu Ser Val Ile Gly Glu Leu Gly Glu 
65                  70                  75                  80  

Gly Asn Ser Trp Asp Glu Asp Val Phe Ala Phe Val Ala Lys Glu Val 
                85                  90                  95      

Gln Asn Gly Ala Val Ile Asn Arg Ala Ala Thr Glu Ala Lys Thr Gly 
            100                 105                 110         

Ser Pro Thr Arg Gly Gly Arg Pro Gly Thr His Ala Val Lys Lys Asp 
        115                 120                 125             

Gly Lys Trp Ala Val Asn Gly Arg Lys Thr Phe Thr Thr Met Ser Gln 
    130                 135                 140                 

Ala Leu Asp Tyr Phe Leu Val Thr Ala Trp Ile Glu Asp Lys Gln Thr 
145                 150                 155                 160 

Thr Gly Val Phe Leu Ile His Lys Asp Asp Pro Gly Leu Ser Ile Glu 
                165                 170                 175     

Glu Thr Trp Asp Met Met Ala Met Arg Ala Thr Gly Ser His Asp Leu 
            180                 185                 190         

Val Leu Asn Glu Val Met Leu Asp Glu Asn Lys Leu Val Glu Leu Leu 
        195                 200                 205             

Gln Gly Pro Arg Gly Ala Lys Pro Asn Gly Trp Leu Leu His Ile Pro 
    210                 215                 220                 

Ala Ile Tyr Leu Gly Val Ala Gln Ala Ala Arg Asp Tyr Ala Val Gln 
225                 230                 235                 240 

Phe Ala Ser Glu Tyr Ser Pro Asn Ser Leu Asn Gly Pro Ile Lys Asn 
                245                 250                 255     

Val Pro Ala Val Gln Gln Arg Thr Gly Glu Met Glu Leu Glu Leu Leu 
            260                 265                 270         

Asn Ala Arg His Phe Leu Phe His Ile Ala Gln Leu Tyr Asp Asp Pro 
        275                 280                 285             

Val Arg Arg Pro His Leu Thr Ser Glu Leu Gly Ala Ala Lys His Ile 
    290                 295                 300                 

Val Thr Asn Ala Ala Leu Ser Val Val Asp Lys Ala Met Arg Ile Val 
305                 310                 315                 320 

Gly Ala Lys Ser Leu Glu Arg Thr Asn Pro Leu Gln Arg Tyr Tyr Arg 
                325                 330                 335     

Asp Val Arg Ala Gly Leu His Asn Pro Pro Met Asp Asp Ala Val 
            340                 345                 350     

<210>   1027
<211>   346
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   1027
Phe Gln Glu Arg Glu Cys Glu Leu Arg Glu Leu Gly Ser Phe Pro Phe 
                5                   10                  15      

Glu Asn Ile Asn Glu Leu Lys Asp Ile Gly Tyr Thr Thr Leu Thr Leu 
            20                  25                  30          

Pro Lys Asp Cys Gly Gly Gln Glu Ile Ser Leu Tyr Asp Phe Val Leu 
        35                  40                  45              

Tyr Gln Glu Lys Ile Ala Glu Gly Asp Gly Ala Thr Ala Leu Ser Ile 
    50                  55                  60                  

Gly Trp His Leu Gly Ile Val Lys Glu Leu Thr Glu Asn Gln Ser Trp 
65                  70                  75                  80  

Lys Pro Asp Met Phe Ala Trp Phe Cys Glu Glu Val Lys Lys Gly Ala 
                85                  90                  95      

Leu Phe Asn Arg Ala Ala Thr Glu Arg Lys Thr Gly Ser Pro Thr Arg 
            100                 105                 110         

Gly Gly Arg Pro Glu Thr Leu Ala Val Lys Lys Gly Glu Lys Trp Ile 
        115                 120                 125             

Ile Asn Gly Arg Lys Thr Phe Thr Thr Met Ala Pro Met Leu Asp Tyr 
    130                 135                 140                 

Phe Ile Ile Ser Ala Ser Ile Glu Gly Arg Glu Glu Ile Gly Glu Phe 
145                 150                 155                 160 

Val Val Pro Arg Ala Gln Lys Gly Val Ser Ile Glu Glu Thr Trp Asp 
                165                 170                 175     

Ser Val Ala Met Arg Gly Thr Ala Ser His Asp Leu Val Leu Arg Asn 
            180                 185                 190         

Val Glu Ile Ser Asp Lys Tyr Phe Thr Asp Ile Lys Gly Ser Gln Ser 
        195                 200                 205             

Lys Pro Lys Gly Val Gly Trp Leu Leu His Ile Pro Ala Cys Tyr Leu 
    210                 215                 220                 

Gly Ile Ala Gln Ala Ala Arg Asn Tyr Ala Leu Arg Phe Ala Glu Ser 
225                 230                 235                 240 

Tyr Gln Pro Asn Ser Leu Lys His Pro Ile Ser Ser Leu Pro Asn Ile 
                245                 250                 255     

Arg Arg Leu Val Gly Glu Leu Glu Leu Glu Leu Met Gln Ala Arg Met 
            260                 265                 270         

Phe Leu Tyr Gln Ile Ala Lys Lys Tyr Asp Glu Val Asp Asp Lys Gln 
        275                 280                 285             

Ser Leu Gln Ala Glu Leu Ala Ala Ala Lys Tyr Ile Ala Thr Asn Ala 
    290                 295                 300                 

Ala Ile Ser Val Val Asp Lys Ala Met Arg Ile Val Gly Ala Lys Ser 
305                 310                 315                 320 

Leu Ser Glu Lys Asn Pro Leu His Arg Tyr Tyr Leu Asn Val Arg Ala 
                325                 330                 335     

Gly Leu His Asn Pro Pro Met Asp Asp Val 
            340                 345     

<210>   1028
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1021

<400>   1028
Met Tyr Asp Ile Tyr Gly Glu Ala Ala Leu Pro Ala Asp Val Arg Glu 
                5                   10                  15      

Arg Leu Arg Ile Thr Arg Asp Leu Ala Gln Ala Phe His Glu Arg Ala 
            20                  25                  30          

Pro Glu His Asp Arg Ala Gly Asp Phe Pro Phe Glu Asn Ile Glu Asp 
        35                  40                  45              

Leu Lys Ala Ser Gly Tyr Val Arg Trp Thr Val Pro Val Glu Tyr Gly 
    50                  55                  60                  

Gly Leu Gly Leu Ser Leu Glu Glu Met Leu Met His Gln Glu Val Leu 
65                  70                  75                  80  

Ala Lys Gly Asp Gly Ser Thr Ala Leu Ala Ile Gly Trp His Val Gly 
                85                  90                  95      

Ile Leu Leu His Leu Arg Glu Thr Gly Ala Phe Pro Asp Glu Leu Phe 
            100                 105                 110         

Arg Met Val Cys Glu Ser Val Val Lys Glu Gly Ala Leu Ile Asn Ser 
        115                 120                 125             

Cys Ala Thr Glu Pro Ala Thr Gly Ser Pro Ser Arg Gly Gly Lys Pro 
    130                 135                 140                 

Glu Thr Thr Ala Val Lys Val Pro Gly Gly Tyr Arg Ile Thr Gly Arg 
145                 150                 155                 160 

Lys Thr Phe Ser Thr Leu Ser Pro Ala Leu Thr Trp Ile Met Val Thr 
                165                 170                 175     

Ala Thr Val Ala Asp Glu Asp Val Val Gly Gln Phe Leu Val Arg Lys 
            180                 185                 190         

Glu Asp Val Glu Ile Val Glu Thr Trp Asp Thr Leu Gly Met Arg Ala 
        195                 200                 205             

Thr Gly Ser His Asp Ile Val Leu Lys Asp Val Phe Val Pro Glu Glu 
    210                 215                 220                 

Arg Val Ile Val Ile Gln Arg Pro Gly Val Gln Ala Glu Arg Arg Pro 
225                 230                 235                 240 

Asp Gly Ser Gly Trp Leu Leu His Ile Pro Ala Cys Tyr Leu Gly Ile 
                245                 250                 255     

Ala Leu Ala Ala Arg Asp Phe Ala Leu Glu Tyr Ala Ala Thr Tyr Arg 
            260                 265                 270         

Pro Asn Thr Leu Pro His Pro Ile Ala Glu Val Pro His Val Glu Gln 
        275                 280                 285             

Lys Leu Gly Glu Met Glu Leu Lys Leu Leu Ala Ala Arg Thr Leu Leu 
    290                 295                 300                 

Tyr Asp Leu Ala Arg Arg Phe Asp Ala Ala Ser Pro Glu Glu Arg Ile 
305                 310                 315                 320 

Lys Leu Gln Pro Gln Phe Gly Ala Val Lys Thr Leu Ala Thr Asn Ala 
                325                 330                 335     

Ala Asn Gln Val Val Asp Leu Ala Met Arg Val Val Gly Gly Arg Ser 
            340                 345                 350         

Leu Ser Arg Ala Leu Pro Leu Glu Arg Tyr Tyr Arg Asp Val Arg Ala 
        355                 360                 365             

Gly Leu His Asn Pro Pro Met Asp Asp Val Val Tyr Arg Asn Leu Ala 
    370                 375                 380                 

Lys Ala Ala Leu Ala Arg Arg Ala Ala Gly Gln Ala Gly Arg 
385                 390                 395             

<210>   1029
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1021

<400>   1029
Met Tyr Asp Ile Tyr Gly Glu Ala Ala Leu Pro Ala Asp Val Arg Glu 
                5                   10                  15      

Arg Leu Arg Ile Thr Arg Asp Leu Ala Gln Ala Phe His Glu Arg Ala 
            20                  25                  30          

Pro Glu His Asp Arg Ala Gly Asp Phe Pro Phe Glu Asn Ile Glu Asp 
        35                  40                  45              

Leu Lys Ala Ser Gly Tyr Val Arg Trp Thr Val Pro Val Glu Tyr Gly 
    50                  55                  60                  

Gly Leu Gly Leu Ser Leu Glu Glu Met Leu Met His Gln Glu Val Leu 
65                  70                  75                  80  

Ala Lys Gly Asp Gly Ser Thr Ala Leu Ala Ile Gly Trp His Val Gly 
                85                  90                  95      

Ile Leu Leu His Leu Arg Glu Thr Gly Ala Phe Pro Asp Glu Leu Phe 
            100                 105                 110         

Arg Met Val Cys Glu Ser Val Val Lys Glu Gly Ala Leu Ile Asn Ser 
        115                 120                 125             

Cys Ala Thr Glu Pro Ala Thr Gly Ser Pro Ser Arg Gly Gly Lys Pro 
    130                 135                 140                 

Glu Thr Thr Ala Val Lys Val Pro Gly Gly Tyr Arg Ile Thr Gly Arg 
145                 150                 155                 160 

Lys Thr Phe Ser Thr Leu Ser Pro Ala Leu Thr Trp Ile Met Val Thr 
                165                 170                 175     

Ala Thr Val Ala Asp Glu Asp Val Val Gly Gln Phe Leu Val Arg Lys 
            180                 185                 190         

Glu Asp Val Glu Ile Val Glu Thr Trp Asp Thr Leu Gly Met Arg Ala 
        195                 200                 205             

Thr Gly Ser His Asp Ile Val Leu Lys Asp Val Phe Val Pro Glu Glu 
    210                 215                 220                 

Arg Val Ile Val Ile Gln Arg Pro Gly Val Gln Ala Glu Arg Arg Pro 
225                 230                 235                 240 

Asp Gly Ser Gly Trp Leu Leu His Ile Pro Ala Cys Tyr Leu Gly Ile 
                245                 250                 255     

Ala Leu Ala Ala Arg Asp Phe Ala Leu Glu Tyr Ala Ala Thr Tyr Arg 
            260                 265                 270         

Pro Asn Thr Leu Pro His Pro Ile Ala Glu Val Pro His Val Glu Gln 
        275                 280                 285             

Lys Leu Gly Glu Met Glu Leu Lys Leu Leu Ala Ala Arg Thr Leu Leu 
    290                 295                 300                 

Tyr Asp Leu Ala Arg Arg Phe Asp Ala Ala Ser Pro Glu Glu Arg Val 
305                 310                 315                 320 

Lys Leu Gln Pro Gln Phe Gly Ala Val Lys Thr Ile Ala Thr Asn Ala 
                325                 330                 335     

Ala Asn Gln Val Val Asp Leu Ala Met Arg Val Val Gly Gly Arg Ser 
            340                 345                 350         

Leu Ser Arg Ala Leu Pro Leu Glu Arg Tyr Tyr Arg Asp Val Arg Ala 
        355                 360                 365             

Gly Leu His Asn Pro Pro Met Asp Asp Val Val Tyr Arg Asn Leu Ala 
    370                 375                 380                 

Lys Ala Ala Leu Ala Arg Arg Ala Ala Gly Gln Ala Gly Arg 
385                 390                 395             

<210>   1030
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1021

<400>   1030
Met Tyr Asp Ile Tyr Gly Glu Ala Ala Leu Pro Ala Asp Val Arg Glu 
                5                   10                  15      

Arg Leu Arg Ile Thr Arg Asp Leu Ala Gln Ala Phe His Glu Arg Ala 
            20                  25                  30          

Pro Glu His Asp Arg Ala Gly Asp Phe Pro Phe Glu Asn Ile Glu Asp 
        35                  40                  45              

Leu Lys Ala Ser Gly Tyr Val Arg Trp Thr Val Pro Val Glu Tyr Gly 
    50                  55                  60                  

Gly Leu Gly Leu Ser Leu Glu Glu Met Leu Met His Gln Glu Val Leu 
65                  70                  75                  80  

Ala Lys Gly Asp Gly Ser Thr Ala Leu Ala Ile Gly Trp His Val Gly 
                85                  90                  95      

Ile Leu Leu His Leu Arg Glu Thr Gly Ala Phe Pro Asp Glu Leu Phe 
            100                 105                 110         

Arg Met Val Cys Glu Ser Val Val Lys Glu Gly Ala Leu Ile Asn Ser 
        115                 120                 125             

Cys Ala Thr Glu Pro Ala Thr Gly Ser Pro Ser Arg Gly Gly Lys Pro 
    130                 135                 140                 

Glu Thr Thr Ala Val Lys Val Pro Gly Gly Tyr Arg Ile Thr Gly Arg 
145                 150                 155                 160 

Lys Thr Phe Ser Thr Leu Ser Pro Ala Leu Thr Trp Ile Met Val Thr 
                165                 170                 175     

Ala Thr Val Ala Asp Glu Asp Val Val Gly Gln Phe Leu Val Arg Lys 
            180                 185                 190         

Glu Asp Val Glu Ile Val Glu Thr Trp Asp Thr Leu Gly Met Arg Ala 
        195                 200                 205             

Thr Gly Ser His Asp Ile Val Leu Lys Asp Val Phe Val Pro Glu Glu 
    210                 215                 220                 

Arg Val Ile Val Ile Gln Arg Pro Gly Val Gln Ala Glu Arg Arg Pro 
225                 230                 235                 240 

Asp Gly Ser Gly Trp Leu Leu His Ile Pro Ala Cys Tyr Leu Gly Ile 
                245                 250                 255     

Ala Leu Ala Ala Arg Asp Phe Ala Leu Glu Tyr Ala Ala Thr Tyr Arg 
            260                 265                 270         

Pro Asn Thr Leu Pro His Pro Ile Ala Glu Val Pro His Val Glu Gln 
        275                 280                 285             

Lys Leu Gly Glu Met Glu Leu Lys Leu Leu Ala Ala Arg Thr Leu Leu 
    290                 295                 300                 

Tyr Asp Leu Ala Arg Arg Phe Asp Ala Ala Ser Pro Glu Glu Arg Val 
305                 310                 315                 320 

Lys Leu Gln Pro Gln Phe Gly Ala Val Lys Thr Leu Ala Thr Asn Ala 
                325                 330                 335     

Ala Asn Gln Val Val Asp Leu Ala Met Arg Val Val Gly Gly Arg Ser 
            340                 345                 350         

Leu Ser Arg Ala Leu Pro Leu Glu Arg Tyr Tyr Arg Asp Val Arg Ala 
        355                 360                 365             

Gly Leu His Asn Pro Pro Met Asp Asp Val Val Tyr Arg Asn Leu Ala 
    370                 375                 380                 

Lys Ala Ala Leu Ala Arg Arg Ala Ala Gly Asn Ala Gly Arg 
385                 390                 395             

<210>   1031
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1021

<400>   1031
Met Tyr Asp Ile Tyr Gly Glu Ala Ala Leu Pro Ala Asp Val Arg Glu 
                5                   10                  15      

Arg Leu Arg Ile Thr Arg Asp Leu Ala Gln Ala Phe His Glu Arg Ala 
            20                  25                  30          

Pro Glu His Asp Arg Ala Gly Asp Phe Pro Phe Glu Asn Ile Glu Asp 
        35                  40                  45              

Leu Lys Ala Ser Gly Tyr Val Arg Trp Thr Val Pro Val Glu Tyr Gly 
    50                  55                  60                  

Gly Leu Gly Leu Ser Leu Glu Glu Met Leu Met His Gln Glu Val Leu 
65                  70                  75                  80  

Ala Lys Gly Asp Gly Ser Thr Ala Leu Ala Ile Gly Trp His Val Gly 
                85                  90                  95      

Ile Ile Leu His Leu Arg Glu Thr Gly Ala Phe Pro Asp Glu Leu Phe 
            100                 105                 110         

Arg Met Val Cys Glu Ser Val Val Lys Glu Gly Ala Leu Ile Asn Ser 
        115                 120                 125             

Cys Ala Thr Glu Pro Ala Thr Gly Ser Pro Ser Arg Gly Gly Lys Pro 
    130                 135                 140                 

Glu Thr Thr Ala Val Lys Val Pro Gly Gly Tyr Arg Ile Thr Gly Arg 
145                 150                 155                 160 

Lys Thr Phe Ser Thr Leu Ser Pro Ala Leu Thr Trp Ile Met Val Thr 
                165                 170                 175     

Ala Thr Val Ala Asp Glu Asp Val Val Gly Gln Phe Leu Val Arg Lys 
            180                 185                 190         

Glu Asp Val Glu Ile Val Glu Thr Trp Asp Thr Leu Gly Met Arg Ala 
        195                 200                 205             

Thr Gly Ser His Asp Ile Val Leu Lys Asp Val Phe Val Pro Glu Glu 
    210                 215                 220                 

Arg Val Ile Val Ile Gln Arg Pro Gly Val Gln Ala Glu Arg Arg Pro 
225                 230                 235                 240 

Asp Gly Ser Gly Trp Leu Leu His Ile Pro Ala Cys Tyr Leu Gly Ile 
                245                 250                 255     

Ala Leu Ala Ala Arg Asp Phe Ala Leu Glu Tyr Ala Ala Thr Tyr Arg 
            260                 265                 270         

Pro Asn Thr Leu Pro His Pro Ile Ala Glu Val Pro His Val Glu Gln 
        275                 280                 285             

Lys Leu Gly Glu Met Glu Leu Lys Leu Leu Ala Ala Arg Thr Leu Leu 
    290                 295                 300                 

Tyr Asp Leu Ala Arg Arg Phe Asp Ala Ala Ser Pro Glu Glu Arg Val 
305                 310                 315                 320 

Lys Leu Gln Pro Gln Phe Gly Ala Val Lys Thr Leu Ala Thr Asn Ala 
                325                 330                 335     

Ala Asn Gln Val Val Asp Leu Ala Met Arg Val Val Gly Gly Arg Ser 
            340                 345                 350         

Leu Ser Arg Ala Leu Pro Leu Glu Arg Tyr Tyr Arg Asp Val Arg Ala 
        355                 360                 365             

Gly Leu His Asn Pro Pro Met Asp Asp Val Val Tyr Arg Asn Leu Ala 
    370                 375                 380                 

Lys Ala Ala Leu Ala Arg Arg Ala Ala Gly Gln Ala Gly Arg 
385                 390                 395             

<210>   1032
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1021

<400>   1032
Met Tyr Asp Ile Tyr Gly Glu Ala Ala Leu Pro Ala Asp Val Arg Glu 
                5                   10                  15      

Arg Leu Arg Ile Thr Arg Asp Leu Ala Gln Ala Phe His Glu Arg Ala 
            20                  25                  30          

Pro Glu His Asp Arg Ala Gly Asp Phe Pro Phe Glu Asn Ile Glu Asp 
        35                  40                  45              

Leu Lys Ala Ser Gly Tyr Val Arg Trp Thr Val Pro Val Glu Tyr Gly 
    50                  55                  60                  

Gly Leu Gly Leu Ser Leu Glu Glu Met Leu Met His Gln Glu Val Leu 
65                  70                  75                  80  

Ala Lys Gly Asp Gly Ser Thr Ala Leu Ala Ile Gly Trp His Val Gly 
                85                  90                  95      

Ile Leu Leu His Leu Arg Glu Thr Gly Ala Phe Pro Asp Glu Leu Phe 
            100                 105                 110         

Arg Met Val Cys Glu Ser Val Val Lys Glu Gly Ala Leu Ile Asn Ser 
        115                 120                 125             

Cys Ala Thr Glu Pro Ala Thr Gly Ser Pro Ser Arg Gly Gly Lys Pro 
    130                 135                 140                 

Glu Thr Thr Ala Val Lys Val Pro Gly Gly Tyr Arg Ile Thr Gly Arg 
145                 150                 155                 160 

Lys Thr Phe Ser Thr Leu Ser Pro Ala Leu Thr Trp Ile Met Val Thr 
                165                 170                 175     

Ala Thr Val Ala Asp Glu Asp Val Val Gly Gln Phe Leu Val Arg Lys 
            180                 185                 190         

Glu Asp Val Glu Ile Val Glu Thr Trp Asp Thr Leu Gly Met Arg Ala 
        195                 200                 205             

Thr Gly Ser His Asp Ile Val Leu Lys Asp Val Phe Val Pro Glu Glu 
    210                 215                 220                 

Arg Val Ile Val Ile Gln Arg Pro Gly Val Gln Ala Glu Arg Arg Pro 
225                 230                 235                 240 

Asp Gly Ser Gly Trp Leu Leu His Ile Pro Ala Cys Tyr Leu Gly Ile 
                245                 250                 255     

Ala Leu Ala Ala Arg Asp Phe Ala Leu Glu Tyr Ala Ala Thr Tyr Arg 
            260                 265                 270         

Pro Asn Thr Leu Pro His Pro Ile Ala Glu Val Pro His Val Glu Gln 
        275                 280                 285             

Lys Leu Gly Glu Met Glu Leu Lys Leu Leu Ala Ala Arg Thr Leu Leu 
    290                 295                 300                 

Tyr Asp Leu Ala Arg Arg Phe Asp Ala Ala Ser Pro Glu Glu Arg Val 
305                 310                 315                 320 

Lys Leu Gln Pro Asn Phe Gly Ala Val Lys Thr Leu Ala Thr Asn Ala 
                325                 330                 335     

Ala Asn Gln Val Val Asp Leu Ala Met Arg Val Val Gly Gly Arg Ser 
            340                 345                 350         

Leu Ser Arg Ala Leu Pro Leu Glu Arg Tyr Tyr Arg Asp Val Arg Ala 
        355                 360                 365             

Gly Leu His Asn Pro Pro Met Asp Asp Val Val Tyr Arg Asn Leu Ala 
    370                 375                 380                 

Lys Ala Ala Leu Ala Arg Arg Ala Ala Gly Gln Ala Gly Arg 
385                 390                 395             

<210>   1033
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1022

<400>   1033
atgtacgaca tctatggaga agccgcactg cccgcggacg tgcgcgagcg cctgcgcatc       60

acgcgcgatc tcgcccaagc cttccacgag cgcgcgcccg agcacgatcg cgcgggcgac      120

tttccgtttg agaacatcga ggatttgaag gcgtcgggtt acgtgcgctg gacggtgccc      180

gtggaatacg gggggctcgg cctaagcctc gaggagatgc tcatgcatca ggaggtgctg      240

gcgaaaggcg acggatcgac cgcgctcgcg attggctggc acgtgggcat tctgcttcac      300

ctgcgcgaga cgggggcgtt cccggatgag ctgtttcgca tggtgtgcga gtccgtcgtg      360

aaggagggcg cgctcatcaa cagctgcgcc acggagcccg ccacggggag cccgagccgc      420

ggcggcaagc cggagaccac cgccgtgaaa gtgcccggcg ggtatcggat cacgggccgc      480

aagacattca gcacgctctc gcctgcgctc acctggatca tggtgaccgc caccgtggcg      540

gacgaggacg tggtggggca gtttctcgtt cgaaaagagg acgtcgagat cgtcgagacg      600

tgggacacgc tcggcatgcg cgccaccggc agccacgaca ttgtgctgaa ggatgtgttt      660

gtgccggagg agcgggtgat tgtcatccag cgcccgggcg tgcaggccga gcgacggccg      720

gacgggagcg gttggctgct ccacattccg gcgtgttatc tcggcatcgc cctcgcggcg      780

cgcgactttg cgctggagta cgccgcgacg taccggccca acacgttgcc gcatcccatc      840

gcggaggttc cgcacgtcga gcagaaactc ggcgagatgg agctgaagct gctcgccgcc      900

cgcacgctcc tgtacgatct cgcccgccgc ttcgacgccg cctcgccgga ggaacgcatt      960

aagctgcaac cccagttcgg cgcggtgaag acgctcgcga cgaatgccgc caatcaggtg     1020

gtggatctcg ccatgcgggt cgtcggcggc cgcagcctgt cgcgcgccct gcccctcgag     1080

cggtactacc gcgacgtccg cgccggcctg cacaatccgc cgatggacga cgtggtctac     1140

cgcaacctgg cgaaggccgc gctcgcgcgc cgcgccgcgg ggcaggcggg gaggtga        1197


<210>   1034
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1022

<400>   1034
atgtacgaca tctatggaga agccgcactg cccgcggacg tgcgcgagcg cctgcgcatc       60

acgcgcgatc tcgcccaagc cttccacgag cgcgcgcccg agcacgatcg cgcgggcgac      120

tttccgtttg agaacatcga ggatttgaag gcgtcgggtt acgtgcgctg gacggtgccc      180

gtggaatacg gggggctcgg cctaagcctc gaggagatgc tcatgcatca ggaggtgctg      240

gcgaaaggcg acggatcgac cgcgctcgcg attggctggc acgtgggcat tctgcttcac      300

ctgcgcgaga cgggggcgtt cccggatgag ctgtttcgca tggtgtgcga gtccgtcgtg      360

aaggagggcg cgctcatcaa cagctgcgcc acggagcccg ccacggggag cccgagccgc      420

ggcggcaagc cggagaccac cgccgtgaaa gtgcccggcg ggtatcggat cacgggccgc      480

aagacattca gcacgctctc gcctgcgctc acctggatca tggtgaccgc caccgtggcg      540

gacgaggacg tggtggggca gtttctcgtt cgaaaagagg acgtcgagat cgtcgagacg      600

tgggacacgc tcggcatgcg cgccaccggc agccacgaca ttgtgctgaa ggatgtgttt      660

gtgccggagg agcgggtgat tgtcatccag cgcccgggcg tgcaggccga gcgacggccg      720

gacgggagcg gttggctgct ccacattccg gcgtgttatc tcggcatcgc cctcgcggcg      780

cgcgactttg cgctggagta cgccgcgacg taccggccca acacgttgcc gcatcccatc      840

gcggaggttc cgcacgtcga gcagaaactc ggcgagatgg agctgaagct gctcgccgcc      900

cgcacgctcc tgtacgatct cgcccgccgc ttcgacgccg cctcgccgga ggaacgcgtc      960

aagctgcaac cccagttcgg cgcggtgaag acgattgcga cgaatgccgc caatcaggtg     1020

gtggatctcg ccatgcgggt cgtcggcggc cgcagcctgt cgcgcgccct gcccctcgag     1080

cggtactacc gcgacgtccg cgccggcctg cacaatccgc cgatggacga cgtggtctac     1140

cgcaacctgg cgaaggccgc gctcgcgcgc cgcgccgcgg ggcaggcggg gaggtga        1197


<210>   1035
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1022

<400>   1035
atgtacgaca tctatggaga agccgcactg cccgcggacg tgcgcgagcg cctgcgcatc       60

acgcgcgatc tcgcccaagc cttccacgag cgcgcgcccg agcacgatcg cgcgggcgac      120

tttccgtttg agaacatcga ggatttgaag gcgtcgggtt acgtgcgctg gacggtgccc      180

gtggaatacg gggggctcgg cctaagcctc gaggagatgc tcatgcatca ggaggtgctg      240

gcgaaaggcg acggatcgac cgcgctcgcg attggctggc acgtgggcat tctgcttcac      300

ctgcgcgaga cgggggcgtt cccggatgag ctgtttcgca tggtgtgcga gtccgtcgtg      360

aaggagggcg cgctcatcaa cagctgcgcc acggagcccg ccacggggag cccgagccgc      420

ggcggcaagc cggagaccac cgccgtgaaa gtgcccggcg ggtatcggat cacgggccgc      480

aagacattca gcacgctctc gcctgcgctc acctggatca tggtgaccgc caccgtggcg      540

gacgaggacg tggtggggca gtttctcgtt cgaaaagagg acgtcgagat cgtcgagacg      600

tgggacacgc tcggcatgcg cgccaccggc agccacgaca ttgtgctgaa ggatgtgttt      660

gtgccggagg agcgggtgat tgtcatccag cgcccgggcg tgcaggccga gcgacggccg      720

gacgggagcg gttggctgct ccacattccg gcgtgttatc tcggcatcgc cctcgcggcg      780

cgcgactttg cgctggagta cgccgcgacg taccggccca acacgttgcc gcatcccatc      840

gcggaggttc cgcacgtcga gcagaaactc ggcgagatgg agctgaagct gctcgccgcc      900

cgcacgctcc tgtacgatct cgcccgccgc ttcgacgccg cctcgccgga ggaacgcgtc      960

aagctgcaac cccagttcgg cgcggtgaag acgctcgcga cgaatgccgc caatcaggtg     1020

gtggatctcg ccatgcgggt cgtcggcggc cgcagcctgt cgcgcgccct gcccctcgag     1080

cggtactacc gcgacgtccg cgccggcctg cacaatccgc cgatggacga cgtggtctac     1140

cgcaacctgg cgaaggccgc gctcgcgcgc cgcgccgcgg ggaatgcggg gaggtga        1197


<210>   1036
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1022

<400>   1036
atgtacgaca tctatggaga agccgcactg cccgcggacg tgcgcgagcg cctgcgcatc       60

acgcgcgatc tcgcccaagc cttccacgag cgcgcgcccg agcacgatcg cgcgggcgac      120

tttccgtttg agaacatcga ggatttgaag gcgtcgggtt acgtgcgctg gacggtgccc      180

gtggaatacg gggggctcgg cctaagcctc gaggagatgc tcatgcatca ggaggtgctg      240

gcgaaaggcg acggatcgac cgcgctcgcg attggctggc acgtgggcat tattcttcac      300

ctgcgcgaga cgggggcgtt cccggatgag ctgtttcgca tggtgtgcga gtccgtcgtg      360

aaggagggcg cgctcatcaa cagctgcgcc acggagcccg ccacggggag cccgagccgc      420

ggcggcaagc cggagaccac cgccgtgaaa gtgcccggcg ggtatcggat cacgggccgc      480

aagacattca gcacgctctc gcctgcgctc acctggatca tggtgaccgc caccgtggcg      540

gacgaggacg tggtggggca gtttctcgtt cgaaaagagg acgtcgagat cgtcgagacg      600

tgggacacgc tcggcatgcg cgccaccggc agccacgaca ttgtgctgaa ggatgtgttt      660

gtgccggagg agcgggtgat tgtcatccag cgcccgggcg tgcaggccga gcgacggccg      720

gacgggagcg gttggctgct ccacattccg gcgtgttatc tcggcatcgc cctcgcggcg      780

cgcgactttg cgctggagta cgccgcgacg taccggccca acacgttgcc gcatcccatc      840

gcggaggttc cgcacgtcga gcagaaactc ggcgagatgg agctgaagct gctcgccgcc      900

cgcacgctcc tgtacgatct cgcccgccgc ttcgacgccg cctcgccgga ggaacgcgtc      960

aagctgcaac cccagttcgg cgcggtgaag acgctcgcga cgaatgccgc caatcaggtg     1020

gtggatctcg ccatgcgggt cgtcggcggc cgcagcctgt cgcgcgccct gcccctcgag     1080

cggtactacc gcgacgtccg cgccggcctg cacaatccgc cgatggacga cgtggtctac     1140

cgcaacctgg cgaaggccgc gctcgcgcgc cgcgccgcgg ggcaggcggg gaggtga        1197


<210>   1037
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1022

<400>   1037
atgtacgaca tctatggaga agccgcactg cccgcggacg tgcgcgagcg cctgcgcatc       60

acgcgcgatc tcgcccaagc cttccacgag cgcgcgcccg agcacgatcg cgcgggcgac      120

tttccgtttg agaacatcga ggatttgaag gcgtcgggtt acgtgcgctg gacggtgccc      180

gtggaatacg gggggctcgg cctaagcctc gaggagatgc tcatgcatca ggaggtgctg      240

gcgaaaggcg acggatcgac cgcgctcgcg attggctggc acgtgggcat tctgcttcac      300

ctgcgcgaga cgggggcgtt cccggatgag ctgtttcgca tggtgtgcga gtccgtcgtg      360

aaggagggcg cgctcatcaa cagctgcgcc acggagcccg ccacggggag cccgagccgc      420

ggcggcaagc cggagaccac cgccgtgaaa gtgcccggcg ggtatcggat cacgggccgc      480

aagacattca gcacgctctc gcctgcgctc acctggatca tggtgaccgc caccgtggcg      540

gacgaggacg tggtggggca gtttctcgtt cgaaaagagg acgtcgagat cgtcgagacg      600

tgggacacgc tcggcatgcg cgccaccggc agccacgaca ttgtgctgaa ggatgtgttt      660

gtgccggagg agcgggtgat tgtcatccag cgcccgggcg tgcaggccga gcgacggccg      720

gacgggagcg gttggctgct ccacattccg gcgtgttatc tcggcatcgc cctcgcggcg      780

cgcgactttg cgctggagta cgccgcgacg taccggccca acacgttgcc gcatcccatc      840

gcggaggttc cgcacgtcga gcagaaactc ggcgagatgg agctgaagct gctcgccgcc      900

cgcacgctcc tgtacgatct cgcccgccgc ttcgacgccg cctcgccgga ggaacgcgtc      960

aagctgcaac ccaatttcgg cgcggtgaag acgctcgcga cgaatgccgc caatcaggtg     1020

gtggatctcg ccatgcgggt cgtcggcggc cgcagcctgt cgcgcgccct gcccctcgag     1080

cggtactacc gcgacgtccg cgccggcctg cacaatccgc cgatggacga cgtggtctac     1140

cgcaacctgg cgaaggccgc gctcgcgcgc cgcgccgcgg ggcaggcggg gaggtga        1197


<210>   1038
<211>   491
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1038
Met Ser Ser Thr Thr Ser Val Lys Tyr Ala Gln Trp Asn Lys Leu Tyr 
                5                   10                  15      

Leu Gly Gly Glu Trp Arg Ser Gly Thr Ser Ser Arg Thr Val Thr Val 
            20                  25                  30          

Arg Asn Pro Tyr Asn Gln Glu Val Leu Ala Glu Phe Pro Leu Ala Ser 
        35                  40                  45              

Val Glu Asp Ile Asp Gln Ala Tyr Arg Lys Ala Gln Ala Ala Gln Gln 
    50                  55                  60                  

Gly Trp Ala Glu Glu Ser Ala Phe Thr Arg Ala Glu Val Met Glu Arg 
65                  70                  75                  80  

Ala Ala Ser Ile Leu Ala Gln Arg Lys Asp Glu Ile Val Arg Tyr Leu 
                85                  90                  95      

Val Glu Glu Thr Gly Ser Ser Gln Leu Lys Ala Ser Ile Glu Val Asp 
            100                 105                 110         

Ala Ser Ile Gly Asp Ile Lys Leu Ala Ala Glu Tyr Ala His Lys Met 
        115                 120                 125             

Thr Ala Val Ile Leu Pro Ser Ala Ile Pro Gly Lys Glu Asn Arg Val 
    130                 135                 140                 

Tyr Arg Thr Pro Val Gly Val Val Gly Ala Ile Thr Pro Trp Asn Trp 
145                 150                 155                 160 

Pro Phe Tyr Leu Ser Ile Arg Val Val Ala Pro Ala Leu Ala Thr Gly 
                165                 170                 175     

Asn Ala Ile Val Leu Lys Ala Asp Ser Gln Thr Pro Ile Thr Gly Gly 
            180                 185                 190         

Leu Leu Val Ala Asp Leu Phe Glu Gln Ala Gly Leu Pro Pro Gly Leu 
        195                 200                 205             

Leu Ser Val Val Val Ala Asp Leu Asp Glu Ile Gly Asp Ala Met Val 
    210                 215                 220                 

Glu His Pro Val Pro Arg Val Ile Ser Phe Thr Gly Ser Thr Ala Ala 
225                 230                 235                 240 

Gly Arg His Ile Ala Glu Val Ala Ala Arg Ser Leu Arg Lys Val Ala 
                245                 250                 255     

Leu Glu Leu Gly Gly Asn Asn Val Phe Ile Val Leu Asp Asp Ala Asp 
            260                 265                 270         

Val Asp Gln Ala Val Ala Ala Ala Ala Phe Gly Lys Tyr Leu His Gln 
        275                 280                 285             

Gly Gln Ile Cys Ile Ala Thr Asn Arg Met Ile Val His Arg Lys Val 
    290                 295                 300                 

Tyr Asp Glu Phe Val Glu Lys Phe Met Ala Ala Thr Glu Lys Val Lys 
305                 310                 315                 320 

Val Gly Asp Pro Ala Asp Pro Glu Thr Val Ile Cys Pro Leu Ile Asn 
                325                 330                 335     

Glu Arg Gln Ala Lys Arg Ile Met Gly Leu Ile Asp Glu Ser Leu Lys 
            340                 345                 350         

Met Gly Ala Arg Leu Val Leu Glu Gly Lys Leu Glu Gly Leu Leu Met 
        355                 360                 365             

Tyr Pro Tyr Ile Leu Ala Asp Val Thr Asn Asp Met Pro Ile Ala Lys 
    370                 375                 380                 

Asn Glu Ile Phe Gly Pro Val Ala Ala Ile Leu Pro Val Asp Ser Glu 
385                 390                 395                 400 

Glu Glu Ala Val Asn Ile Ala Asn Glu Ser Asp Tyr Gly Leu Ser Gly 
                405                 410                 415     

Ala Val Phe Thr Gly Asp Leu Glu Arg Gly Ile Arg Val Ala Gln Arg 
            420                 425                 430         

Ile Val Thr Gly Met Ile His Val Asn Asp Gln Thr Val Asn Val Glu 
        435                 440                 445             

Ser Asn Val Pro Phe Gly Gly Glu Lys Ala Ser Gly Ile Gly Arg Tyr 
    450                 455                 460                 

Cys Gly Glu Trp Gly Ile Glu Glu Phe Thr Thr Leu Lys Trp Ile Ser 
465                 470                 475                 480 

Val Gln Lys Glu Pro Arg Val Tyr Pro Phe Ser 
                485                 490     

<210>   1039
<211>   1476
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1039
gtgtcgagca caacatcggt gaagtacgct caatggaaca aattgtatct tgggggagag       60

tggaggtctg ggacgagcag cagaacggtg acggttcgca atccatacaa tcaggaggtc      120

ctcgcggaat ttccgctggc atcggtggaa gacatcgatc aggcctatcg aaaggcccag      180

gccgcacagc aaggatgggc tgaggagagt gcgttcactc gcgccgaggt gatggagcgc      240

gcagctagta ttctcgcgca gcggaaggat gaaatcgtcc ggtacttggt cgaggaaacg      300

ggaagttctc aactcaaggc gagcatcgaa gtggatgctt ccatcggcga catcaagttg      360

gccgccgagt atgcgcacaa aatgacggcg gtgatcctcc cttccgcgat tcccggcaag      420

gagaatcgcg tgtatcgcac tcccgtcgga gtcgtgggcg ccatcacacc gtggaattgg      480

ccgttttatc tgagtatccg cgtggtggcg ccagcgcttg cgacggggaa cgccatcgtc      540

ctcaaggcag attctcagac gcccatcacc ggcggactcc ttgtcgcgga tctgtttgag      600

caggcagggc ttccaccagg gctcttgagt gtggtggtgg ccgatctcga cgagatcgga      660

gacgcgatgg tcgaacatcc ggttccccgg gtgatctcgt tcacagggtc cacagcggca      720

ggtcggcata tcgctgaggt cgcggcgcga tcgctgcgca aggtggcgct cgaactcggc      780

gggaacaacg tgttcattgt gctcgacgat gcggacgtcg accaggcggt tgccgcggcg      840

gcgttcggga aatatcttca ccaaggccag atctgcatcg caacaaaccg catgattgtc      900

catcgcaagg tgtacgacga gtttgtcgag aagttcatgg cagcgaccga aaaggtgaag      960

gtcggcgatc cggcagaccc cgagacggtg atttgcccgc tcatcaacga gcgccaggca     1020

aaacggatca tggggctcat cgacgagagc ttgaagatgg gggcacgcct ggtcttggag     1080

ggaaagctcg aagggctgct tatgtatcca tacatcctgg cggatgtgac taacgacatg     1140

cccatcgcga aaaacgagat cttcggcccg gtcgcggcca ttctgcccgt ggatagcgag     1200

gaggaggccg tgaacatcgc aaacgagtcg gactatggac tgtccggggc agtgtttacg     1260

ggagatcttg agcgcggcat ccgagtcgcc cagcgcattg tcacagggat gattcacgtc     1320

aatgaccaaa cggtcaatgt ggagtccaat gttccatttg gtggagaaaa ggcttccggc     1380

atcggccgtt attgtggaga gtggggcatt gaggagttca ccacgttgaa gtggatttcc     1440

gtgcagaaag agccgagagt gtatccgttt tcgtaa                               1476


<210>   1040
<211>   481
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   1040
Tyr Glu Asn Leu Asn Lys Asn Phe Ile Ser Gly Glu Trp Arg Asp Gly 
                5                   10                  15      

Gln Gly Glu Thr Thr Tyr Glu Val Lys Asn Pro Tyr Asn Asp Glu Val 
            20                  25                  30          

Leu Gln Glu Ile Lys Met Ala Ser Lys Glu Asp Ile Asp Glu Ala Tyr 
        35                  40                  45              

Lys Ser Ala Glu Gln Ala Lys Lys Lys Trp Ala Lys Phe Asn Pro Phe 
    50                  55                  60                  

Glu Arg Ser Ser Ile Met Glu Lys Ala Val Gln Ile Ile Asp Ala Arg 
65                  70                  75                  80  

Arg Glu Glu Phe Val Asn His Leu Ile Arg Glu Gly Gly Ser Ser His 
                85                  90                  95      

Leu Lys Ala Asn Val Glu Ile Asp Phe Val Ile Ala Ile Thr Arg Glu 
            100                 105                 110         

Ala Ala Ser Phe Pro Leu Arg Met Ser Gly Glu Ile Val Pro Ser Leu 
        115                 120                 125             

Ile Pro Gly Lys Glu Asn Arg Ile Tyr Arg Ser Pro Leu Gly Val Val 
    130                 135                 140                 

Gly Val Ile Gly Pro Phe Asn Phe Pro Met Tyr Leu Ala Met Arg Ser 
145                 150                 155                 160 

Val Ala Pro Ala Leu Ala Val Gly Asn Gly Val Val Leu Lys Pro Asp 
                165                 170                 175     

Asp Gln Thr Ala Val Thr Gly Gly Ile Leu Leu Ala Lys Val Phe Glu 
            180                 185                 190         

Glu Ala Gly Leu Pro Lys Gly Val Phe Asn Val Val Val Pro Asn Ile 
        195                 200                 205             

Glu Asp Ile Gly Asp Ala Phe Val Glu His Pro Ile Pro Arg Leu Ile 
    210                 215                 220                 

Ser Phe Thr Gly Ser Thr Pro Val Gly Arg His Ile Gly Glu Ile Cys 
225                 230                 235                 240 

Gly Arg Asn Ile Lys Lys Val Ala Leu Glu Leu Gly Gly Asn Asn Pro 
                245                 250                 255     

Leu Val Val Leu Glu Asp Ala Lys Val Glu Asn Ala Val Asn Ser Ala 
            260                 265                 270         

Leu Phe Gly Lys Phe Met His Asn Gly Gln Ile Cys Met Ala Ile Asn 
        275                 280                 285             

Arg Ile Ile Val His Lys Asp Ile Tyr Glu Glu Phe Val Glu Lys Phe 
    290                 295                 300                 

Val Glu Lys Ala Lys Lys Ile Lys Val Gly Asn Pro Ser Glu Lys Asp 
305                 310                 315                 320 

Asn Leu Ile Gly Pro Leu Ile Asn Arg Gln Ala Ile Asp Arg Ile Leu 
                325                 330                 335     

Glu Gln Ile Glu Ser Ala Lys Glu Gln Gly Ala Glu Val Val Leu Glu 
            340                 345                 350         

Gly Lys Val Glu Gly Asn Val Met His Pro Tyr Ile Leu Thr Gly Ser 
        355                 360                 365             

Asn Asp Val Ala Thr Ala Gln Asn Glu Met Phe Gly Pro Val Ala Thr 
    370                 375                 380                 

Ile Ile Ser Ala Glu Ser Asp Glu Glu Ala Ile Arg Ile Ala Asn Asp 
385                 390                 395                 400 

Thr Pro Phe Gly Leu Ser Gly Ala Val His Ala Gly Ser Pro Glu Arg 
                405                 410                 415     

Gly Val Glu Val Ala Lys Gln Ile Thr Ser Gly Met Val His Val Asn 
            420                 425                 430         

Asp Gln Ser Val Asn Asp Glu Pro Leu Ile Ala Phe Gly Gly Glu Lys 
        435                 440                 445             

Ala Ser Gly Leu Gly Arg Phe Gly Gly Lys Trp Ser Leu Glu Glu Phe 
    450                 455                 460                 

Thr Thr Val Gln Trp Ile Ser Val Gln Thr Glu Glu Arg Glu Asn Pro 
465                 470                 475                 480 

Phe 
    

<210>   1041
<211>   481
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1041
Ala Ile Tyr Thr Arg Gln Phe Leu Ala Gly Glu Trp Ile Glu Gly Ala 
                5                   10                  15      

Ser Thr Gln Thr Ile Thr Asn Tyr Asn Pro Tyr Thr Gly Glu Lys Ile 
            20                  25                  30          

His Glu Ile Lys Gly Ala Ser Leu Asp Asp Leu Asp Gln Ala Tyr Arg 
        35                  40                  45              

Ala Ala Lys Asn Ala Gln Lys Glu Trp Glu Gln Thr Leu Pro Ala Gln 
    50                  55                  60                  

Lys Gln Glu Val Leu Glu Lys Ala Ala Ala Leu Leu Ala Glu Arg Lys 
65                  70                  75                  80  

Asp Glu Val Ile Glu Arg Leu Val Asn Glu Ala Gly Ser Ser Ile Ile 
                85                  90                  95      

Lys Ala Ser Ile Glu Trp Gly Ala Thr Leu Gln Thr Ile Lys Val Ala 
            100                 105                 110         

Ala Thr Phe Pro Leu Arg Met Glu Gly Lys Ile Leu Pro Ser Asn Ile 
        115                 120                 125             

Pro Gly Lys Glu Asn Arg Ile Tyr Arg Ser Ala Lys Gly Val Ile Gly 
    130                 135                 140                 

Val Ile Ser Pro Phe Asn Phe Pro Leu Val Leu Ala Met Arg Ser Val 
145                 150                 155                 160 

Ala Pro Ala Leu Ala Thr Gly Asn Ala Val Val Leu Lys Cys Ser Ser 
                165                 170                 175     

Asp Ala Pro Ile Thr Ser Gly Leu Leu Ile Ala Glu Leu Phe Glu Glu 
            180                 185                 190         

Ala Gly Leu Pro Lys Gly Val Leu Asn Val Val Val Gly Lys Ala Ala 
        195                 200                 205             

Glu Ile Gly Asp Ala Phe Val Thr His Pro Ile Pro Lys Leu Ile Ser 
    210                 215                 220                 

Phe Thr Gly Ser Thr Glu Val Gly Arg His Ile Ala Gln Leu Ala Ala 
225                 230                 235                 240 

Arg Glu Leu Lys Glu Thr Ala Leu Glu Leu Gly Gly Asn Asn Val Met 
                245                 250                 255     

Ile Val Leu Asp Asp Ala Asp Ile Glu Lys Ala Ala Glu Lys Ala Ala 
            260                 265                 270         

Val Gly Lys Phe Leu His Gln Gly Gln Ile Cys Met Ala Leu Asn Arg 
        275                 280                 285             

Ile Ile Val Asp Ala Ser Ile Tyr Asp Ser Phe Val Glu Val Phe Lys 
    290                 295                 300                 

Glu Lys Val Ser Gln Leu Gln Thr Gly Asn Pro Ala Glu Pro Ala Thr 
305                 310                 315                 320 

Leu Ile Gly Pro Leu Ile Asn Tyr Lys Gln Ile Gly Arg Ile Gln Gln 
                325                 330                 335     

Leu Val Lys Glu Ser Val Ala Gln Gly Ala Val Lys Val Leu Glu Gly 
            340                 345                 350         

His Val Gln Gly Asn Leu Met Ser Pro Thr Ile Leu Ser Glu Val Thr 
        355                 360                 365             

Asn Asp Met Pro Val Ala Lys Glu Glu Ile Phe Gly Pro Ile Ala Pro 
    370                 375                 380                 

Ile Ile Lys Ala Lys Asp Glu Ala Glu Ala Ile Ala Ile Ala Asn Asp 
385                 390                 395                 400 

Ser Pro Tyr Gly Leu Ser Gly Ser Ile Phe Thr Gly Ser Leu His Arg 
                405                 410                 415     

Gly Val Gln Val Ala Lys Gln Ile Asp Thr Gly Met Ile His Val Asn 
            420                 425                 430         

Asp Gln Pro Val Asn Glu Glu Ala His Ile Ser Phe Gly Gly Glu Lys 
        435                 440                 445             

Asp Ser Gly Ile Gly Arg Phe Gly Gly Glu Trp Val Leu Asp Lys Phe 
    450                 455                 460                 

Thr Thr Val Lys Trp Ile Ser Ile Gln Glu Lys Glu Arg Val Tyr Pro 
465                 470                 475                 480 

Phe 
    

<210>   1042
<211>   478
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1042
Asn Lys Gln Tyr Ile Asp Gly Glu Trp Arg Asp Gly Lys Ser Pro Arg 
                5                   10                  15      

Val Leu Arg Asp Arg Asn Pro Tyr Asn Gln Glu Val Leu Ala Glu Phe 
            20                  25                  30          

Gln Ile Ala Thr Asp Ser Asp Val Asp Ala Ala Tyr His Ala Ala Leu 
        35                  40                  45              

Lys Ala Gln Asn Glu Trp Ala Thr Val Asn Pro Tyr Arg Lys Arg Glu 
    50                  55                  60                  

Ile Leu Glu Arg Ala Val Thr Tyr Ile Glu Glu His Glu Glu Glu Ile 
65                  70                  75                  80  

Val Ala Ile Ile Ile Asp Glu Leu Gly Gly Thr Arg Leu Lys Ala Ala 
                85                  90                  95      

Phe Glu Ile Gly Leu Val Lys Asn Met Ile Lys Glu Ala Ser Thr Phe 
            100                 105                 110         

Pro Leu Arg Met Glu Gly Lys Ile Leu Pro Ser Thr Glu Asn Gly Lys 
        115                 120                 125             

Glu Asn Arg Leu Tyr Arg Val Pro Ala Gly Val Val Gly Val Ile Ser 
    130                 135                 140                 

Pro Phe Asn Phe Pro Phe Phe Leu Ser Val Lys Ser Val Ala Pro Ala 
145                 150                 155                 160 

Leu Gly Ala Gly Asn Gly Val Val Leu Lys Pro His Glu Glu Thr Pro 
                165                 170                 175     

Ile Thr Gly Gly Thr Leu Ile Ala Lys Ile Phe Glu Glu Ala Gly Val 
            180                 185                 190         

Pro Lys Gly Leu Leu Asn Val Val Val Thr Glu Ile Asp Glu Ile Gly 
        195                 200                 205             

Asn Ala Phe Val Glu His Pro Ile Pro Arg Ile Ile Ser Phe Thr Gly 
    210                 215                 220                 

Ser Thr Asn Val Gly Ser His Ile Gly Gln Leu Ala Val Lys His Phe 
225                 230                 235                 240 

Lys Lys Pro Leu Leu Glu Leu Gly Gly Asn Ser Ala Phe Leu Ile Phe 
                245                 250                 255     

Ala Asp Ala Asp Leu Asp Tyr Ala Val Gln Ala Ala Thr Phe Ser Arg 
            260                 265                 270         

Phe Thr His Gln Gly Gln Ile Cys Met Ser Ala Asn Arg Ile Phe Val 
        275                 280                 285             

Gln Arg Asp Val Tyr Asp Glu Phe Val Glu Arg Tyr Val Thr Lys Val 
    290                 295                 300                 

Ala Ser Leu Lys Val Gly Asp Pro Arg Asp Pro Glu Thr Val Ile Gly 
305                 310                 315                 320 

Pro Val Met Asn Ser Arg Gln Ala Glu Thr Leu Lys Gln Ala Ile Glu 
                325                 330                 335     

Ser Gly Ile Ala Ala Gly Ala Lys Pro Val Leu His Gly Ala Ile Ser 
            340                 345                 350         

Gly Asn Met Val Glu Pro Thr Ile Leu Ile Asp Ala Ser Pro Glu Met 
        355                 360                 365             

Ala Ile Ala Gln Glu Glu Leu Phe Gly Pro Val Val Cys Val Ile Pro 
    370                 375                 380                 

Phe Asp Thr Glu Glu Glu Ala Val Glu Met Ala Asn Asp Thr Lys Tyr 
385                 390                 395                 400 

Gly Leu Ser Gly Ala Ile His Thr Ala Asn Val Glu Arg Gly Val Glu 
                405                 410                 415     

Ile Ala Lys Arg Ile Gln Thr Gly Met Ile His Val Asn Asp Ile Thr 
            420                 425                 430         

Ile Asn Asp Glu Pro Ile Val Ala Phe Gly Gly Glu Lys His Ser Gly 
        435                 440                 445             

Leu Gly Arg Leu Asn Gly Glu Trp Ser Leu Glu Glu Phe Thr Thr Leu 
    450                 455                 460                 

Lys Trp Val Ser Val His Tyr Ser Gln Arg Val Phe Pro Tyr 
465                 470                 475             

<210>   1043
<211>   483
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   1043
Gln Tyr Glu Glu Leu Asn Lys Gln Phe Ile Gly Gly Arg Trp Arg Asp 
                5                   10                  15      

Gly Ser Ser Arg Asn Val Leu Glu Asn Arg Asn Pro Tyr Thr Gln Lys 
            20                  25                  30          

Val Ile Thr Ser Phe Gln Lys Ala Thr Ser Asp Asp Val Asp Ala Ala 
        35                  40                  45              

Tyr Arg Ala Ala Ala Leu Ala Lys Gln Glu Trp Asp Lys Val Asn Pro 
    50                  55                  60                  

Phe Lys Lys Arg Ala Ile Leu Glu Lys Ala Val Ser Phe Ile Glu Glu 
65                  70                  75                  80  

His Glu Glu Ala Ile Ile Tyr Leu Ile Met Glu Glu Leu Gly Gly Thr 
                85                  90                  95      

Arg Leu Lys Ala Glu Phe Glu Ile Gly Leu Val Lys Asn Met Ile Lys 
            100                 105                 110         

Glu Ala Ala Thr Phe Pro Val Arg Met Glu Gly Lys Ile Leu Pro Ser 
        115                 120                 125             

Thr Ile Asp Gly Lys Glu Asn Arg Leu Tyr Arg Ile Pro Ala Gly Val 
    130                 135                 140                 

Val Gly Val Ile Ser Pro Phe Asn Phe Pro Phe Phe Leu Ser Met Lys 
145                 150                 155                 160 

Ser Val Ala Pro Ala Leu Gly Ala Gly Asn Gly Val Val Leu Lys Pro 
                165                 170                 175     

His Glu Glu Thr Pro Ile Cys Gly Gly Thr Leu Ile Ala Lys Ile Phe 
            180                 185                 190         

Glu Ala Ala Gly Val Pro Asp Gly Leu Leu Asn Val Ile Val Thr Asp 
        195                 200                 205             

Ile Gly Glu Ile Gly Asp Ser Phe Val Glu His Pro Val Pro Arg Ile 
    210                 215                 220                 

Ile Ser Phe Thr Gly Ser Thr Gly Val Gly Ser Tyr Ile Gly Gln Leu 
225                 230                 235                 240 

Ala Val Lys His Phe Lys Lys Pro Leu Leu Glu Leu Gly Gly Asn Ser 
                245                 250                 255     

Ala Leu Ile Val Leu Glu Asp Ala Asp Leu Glu Tyr Ala Val Asn Ala 
            260                 265                 270         

Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met Ser Ala 
        275                 280                 285             

Asn Arg Val Leu Val His Thr Ser Val Tyr Asp Lys Phe Thr Glu Leu 
    290                 295                 300                 

Tyr Glu Ala Lys Val Ser Ser Leu Lys Val Gly Asp Pro Met Asp Pro 
305                 310                 315                 320 

Asp Thr Val Ile Gly Pro Leu Ile Asn Glu Arg Gln Ala Glu Gly Leu 
                325                 330                 335     

Arg Arg Ser Val Glu Lys Ala Ile Glu Glu Gly Ala Val Pro Val Leu 
            340                 345                 350         

Ser Gly Arg Phe Ser Gly Thr Val Ala Glu Pro Val Ile Leu Lys Asp 
        355                 360                 365             

Val Lys Pro Glu Met Ser Ile Ala Lys Glu Glu Leu Phe Gly Pro Ala 
    370                 375                 380                 

Val Cys Ile Met Thr Phe Glu Thr Glu Asp Glu Ala Val Ser Ile Ala 
385                 390                 395                 400 

Asn Ala Thr Pro Phe Gly Leu Ser Gly Ala Val His Thr Ala Asn Val 
                405                 410                 415     

Glu Arg Gly Val Glu Phe Ala Lys Arg Ile Glu Thr Gly Met Ile His 
            420                 425                 430         

Val Asn Asp Thr Thr Ile Asn Asp Glu Pro Asn Val Ala Phe Gly Gly 
        435                 440                 445             

Glu Lys Gln Ser Gly Leu Gly Arg Leu Asn Gly Glu Trp Ser Leu Glu 
    450                 455                 460                 

Glu Phe Thr Thr Leu Lys Trp Ile Ser Val Gln His Glu Lys Arg Gln 
465                 470                 475                 480 

Phe Pro Tyr 
            

<210>   1044
<211>   483
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   1044
Gln Tyr Glu Glu Leu Asn Lys Gln Phe Ile Gly Gly Lys Trp Gln Glu 
                5                   10                  15      

Gly Ser Ser Pro Asn Val Leu Glu Asn Lys Asn Pro Tyr Thr Gln Lys 
            20                  25                  30          

Thr Phe Thr Thr Phe Arg Lys Ala Thr Ala Asp Asp Val Asp Glu Ala 
        35                  40                  45              

Tyr Arg Ala Ala Ala Leu Ala Lys Lys Lys Trp Asp Ala Val Asn Pro 
    50                  55                  60                  

Phe Glu Lys Arg Thr Ile Leu Glu Lys Ala Val Thr Tyr Ile Glu Glu 
65                  70                  75                  80  

Asn Glu Glu Ala Ile Ile Tyr Leu Ile Met Glu Glu Leu Gly Gly Thr 
                85                  90                  95      

Arg Leu Lys Ala Ala Phe Glu Ile Gly Leu Val Lys Asn Ile Ile Lys 
            100                 105                 110         

Glu Ala Ala Thr Phe Pro Ile Arg Met Glu Gly Lys Ile Leu Pro Ser 
        115                 120                 125             

Thr Ile Asp Gly Lys Glu Asn Arg Leu Tyr Arg Val Pro Ala Gly Val 
    130                 135                 140                 

Val Gly Val Ile Ser Pro Phe Asn Phe Pro Phe Phe Leu Ser Met Lys 
145                 150                 155                 160 

Ser Val Ala Pro Ala Leu Gly Ala Gly Asn Gly Val Val Leu Lys Pro 
                165                 170                 175     

His Glu Glu Thr Pro Ile Cys Gly Gly Thr Leu Ile Ala Lys Ile Phe 
            180                 185                 190         

Glu Asn Ala Gly Ile Pro Ala Gly Leu Leu Asn Val Val Val Thr Asp 
        195                 200                 205             

Ile Ala Glu Ile Gly Asp Ser Phe Val Glu His Pro Val Pro Arg Ile 
    210                 215                 220                 

Ile Ser Phe Thr Gly Ser Thr Lys Val Gly Ser Tyr Ile Gly Gln Leu 
225                 230                 235                 240 

Ala Met Lys His Phe Lys Lys Pro Leu Leu Glu Leu Gly Gly Asn Ser 
                245                 250                 255     

Ala Phe Ile Val Leu Glu Asp Ala Asp Ile Glu Tyr Ala Val Asn Ala 
            260                 265                 270         

Ala Val Phe Ser Arg Phe Thr His Gln Gly Gln Ile Cys Met Ser Ala 
        275                 280                 285             

Asn Arg Val Leu Val His Ser Ser Ile Tyr Asp Lys Phe Leu Glu Leu 
    290                 295                 300                 

Tyr Gln Ala Lys Val Glu Ser Leu Lys Val Gly Asp Pro Met Asp Pro 
305                 310                 315                 320 

Asp Thr Ile Ile Gly Pro Leu Ile Asn Ser Arg Gln Thr Asp Gly Leu 
                325                 330                 335     

Met Lys Thr Val Glu Gln Ala Ile Glu Glu Gly Ala Val Pro Val Lys 
            340                 345                 350         

Leu Gly Gly Phe Asn Gly Thr Ile Val Glu Pro Thr Ile Leu Lys Asp 
        355                 360                 365             

Val Lys Pro Phe Met Ser Ile Ala Lys Glu Glu Leu Phe Gly Pro Val 
    370                 375                 380                 

Val Ser Phe Met Lys Phe Asp Ser Glu Asp Glu Ala Val Asp Ile Ala 
385                 390                 395                 400 

Asn Glu Thr Pro Phe Gly Leu Ser Gly Ala Val His Thr Ser Asn Leu 
                405                 410                 415     

Glu Arg Gly Val Ala Phe Ala Lys Arg Ile Glu Thr Gly Met Ile His 
            420                 425                 430         

Val Asn Asp Thr Thr Ile Asn Asp Glu Pro Asn Val Ala Phe Gly Gly 
        435                 440                 445             

Glu Lys Gln Ser Gly Leu Gly Arg Leu Asn Gly Glu Trp Ser Leu Glu 
    450                 455                 460                 

Glu Phe Thr Thr Leu Lys Trp Ile Ser Val Gln His Glu Lys Arg Ser 
465                 470                 475                 480 

Phe Pro Tyr 
            

<210>   1045
<211>   491
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1038

<400>   1045
Met Ser Ser Thr Thr Ser Val Lys Tyr Ala Gln Trp Asn Lys Leu Tyr 
                5                   10                  15      

Leu Gly Gly Glu Trp Arg Ser Gly Thr Ser Ser Arg Thr Val Thr Val 
            20                  25                  30          

Arg Asn Pro Tyr Asn Gln Glu Val Leu Ala Glu Phe Pro Leu Ala Ser 
        35                  40                  45              

Val Glu Asp Ile Asp Gln Ala Tyr Arg Lys Ala Gln Ala Ala Gln Gln 
    50                  55                  60                  

Gly Trp Ala Glu Asp Ser Ala Phe Thr Arg Ala Glu Val Met Glu Arg 
65                  70                  75                  80  

Ala Ala Ser Ile Leu Ala Gln Arg Lys Asp Glu Ile Val Arg Tyr Leu 
                85                  90                  95      

Val Glu Glu Thr Gly Ser Ser Gln Leu Lys Ala Ser Ile Glu Val Asp 
            100                 105                 110         

Ala Ser Ile Gly Asp Ile Lys Leu Ala Ala Glu Tyr Ala His Lys Met 
        115                 120                 125             

Thr Ala Val Ile Leu Pro Ser Ala Ile Pro Gly Lys Glu Asn Arg Val 
    130                 135                 140                 

Tyr Arg Thr Pro Val Gly Val Val Gly Ala Ile Thr Pro Trp Asn Trp 
145                 150                 155                 160 

Pro Phe Tyr Leu Ser Ile Arg Val Val Ala Pro Ala Leu Ala Thr Gly 
                165                 170                 175     

Asn Ala Ile Val Leu Lys Ala Asp Ser Gln Thr Pro Ile Thr Gly Gly 
            180                 185                 190         

Leu Leu Val Ala Asp Leu Phe Glu Gln Ala Gly Leu Pro Pro Gly Leu 
        195                 200                 205             

Leu Ser Val Val Val Ala Asp Leu Asp Glu Ile Gly Asp Ala Met Val 
    210                 215                 220                 

Glu His Pro Val Pro Arg Val Ile Ser Phe Thr Gly Ser Thr Ala Ala 
225                 230                 235                 240 

Gly Arg His Ile Ala Glu Val Ala Ala Arg Ser Leu Arg Lys Val Ala 
                245                 250                 255     

Leu Glu Leu Gly Gly Asn Asn Val Phe Ile Val Leu Asp Asp Ala Asp 
            260                 265                 270         

Val Asp Gln Ala Val Ala Ala Ala Ala Phe Gly Lys Tyr Leu His Gln 
        275                 280                 285             

Gly Gln Ile Cys Ile Ala Thr Asn Arg Met Ile Val His Arg Lys Val 
    290                 295                 300                 

Tyr Asp Glu Phe Val Glu Lys Phe Met Ala Ala Thr Glu Lys Val Lys 
305                 310                 315                 320 

Val Gly Asp Pro Ala Asp Pro Glu Thr Val Ile Cys Pro Leu Ile Asn 
                325                 330                 335     

Glu Arg Gln Ala Lys Arg Ile Met Gly Leu Ile Asp Glu Ser Leu Lys 
            340                 345                 350         

Met Gly Ala Arg Leu Val Leu Glu Gly Lys Leu Glu Gly Leu Leu Met 
        355                 360                 365             

Tyr Pro Tyr Ile Leu Ala Asp Val Thr Asn Asp Met Pro Ile Ala Lys 
    370                 375                 380                 

Asn Glu Ile Phe Gly Pro Val Ala Ala Ile Leu Pro Val Asp Ser Glu 
385                 390                 395                 400 

Glu Glu Ala Val Asn Ile Ala Asn Glu Ser Asp Tyr Gly Leu Ser Gly 
                405                 410                 415     

Ala Val Phe Thr Gly Asp Leu Glu Arg Gly Ile Arg Val Ala Gln Arg 
            420                 425                 430         

Ile Val Thr Gly Met Ile His Val Asn Asp Gln Thr Val Asn Val Glu 
        435                 440                 445             

Ser Asn Val Pro Phe Gly Gly Glu Lys Ala Ser Gly Ile Gly Arg Tyr 
    450                 455                 460                 

Cys Gly Glu Trp Gly Ile Glu Glu Phe Thr Thr Leu Lys Trp Ile Ser 
465                 470                 475                 480 

Val Gln Lys Glu Pro Arg Val Tyr Pro Phe Ser 
                485                 490     

<210>   1046
<211>   491
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1038

<400>   1046
Met Ser Ser Thr Thr Ser Val Lys Tyr Ala Gln Trp Asn Lys Leu Tyr 
                5                   10                  15      

Leu Gly Gly Glu Trp Arg Ser Gly Thr Ser Ser Lys Thr Val Thr Val 
            20                  25                  30          

Arg Asn Pro Tyr Asn Gln Glu Val Leu Ala Glu Phe Pro Leu Ala Ser 
        35                  40                  45              

Val Glu Asp Ile Asp Gln Ala Tyr Arg Lys Ala Gln Ala Ala Gln Gln 
    50                  55                  60                  

Gly Trp Ala Glu Glu Ser Ala Phe Thr Arg Ala Glu Val Met Glu Arg 
65                  70                  75                  80  

Ala Ala Ser Ile Leu Ala Gln Arg Lys Asp Glu Ile Val Arg Tyr Leu 
                85                  90                  95      

Val Glu Glu Thr Gly Ser Ser Gln Leu Lys Ala Ser Ile Glu Val Asp 
            100                 105                 110         

Ala Ser Ile Gly Asp Ile Lys Leu Ala Ala Glu Tyr Ala His Lys Met 
        115                 120                 125             

Thr Ala Val Ile Leu Pro Ser Ala Ile Pro Gly Lys Glu Asn Arg Val 
    130                 135                 140                 

Tyr Arg Thr Pro Val Gly Val Val Gly Ala Ile Thr Pro Trp Asn Trp 
145                 150                 155                 160 

Pro Phe Tyr Leu Ser Ile Arg Val Val Ala Pro Ala Leu Ala Thr Gly 
                165                 170                 175     

Asn Ala Ile Val Leu Lys Ala Asp Ser Gln Thr Pro Ile Thr Gly Gly 
            180                 185                 190         

Leu Leu Val Ala Asp Leu Phe Glu Gln Ala Gly Leu Pro Pro Gly Leu 
        195                 200                 205             

Leu Ser Val Val Val Ala Asp Leu Asp Glu Ile Gly Asp Ala Met Val 
    210                 215                 220                 

Glu His Pro Val Pro Arg Val Ile Ser Phe Thr Gly Ser Thr Ala Ala 
225                 230                 235                 240 

Gly Arg His Ile Ala Glu Val Ala Ala Arg Ser Leu Arg Lys Val Ala 
                245                 250                 255     

Leu Glu Leu Gly Gly Asn Asn Val Phe Ile Val Leu Asp Asp Ala Asp 
            260                 265                 270         

Val Asp Gln Ala Val Ala Ala Ala Ala Phe Gly Lys Tyr Leu His Gln 
        275                 280                 285             

Gly Gln Ile Cys Ile Ala Thr Asn Arg Met Ile Val His Arg Lys Val 
    290                 295                 300                 

Tyr Asp Glu Phe Val Glu Lys Phe Met Ala Ala Thr Glu Lys Val Lys 
305                 310                 315                 320 

Val Gly Asp Pro Ala Asp Pro Glu Thr Val Ile Cys Pro Leu Ile Asn 
                325                 330                 335     

Glu Arg Gln Ala Lys Arg Ile Met Gly Leu Ile Asp Glu Ser Leu Lys 
            340                 345                 350         

Met Gly Ala Arg Leu Val Leu Glu Gly Lys Leu Glu Gly Leu Leu Met 
        355                 360                 365             

Tyr Pro Tyr Ile Leu Ala Asp Val Thr Asn Asp Met Pro Ile Ala Lys 
    370                 375                 380                 

Asn Glu Ile Phe Gly Pro Val Ala Ala Ile Leu Pro Val Asp Ser Glu 
385                 390                 395                 400 

Glu Glu Ala Val Asn Ile Ala Asn Glu Ser Asp Tyr Gly Leu Ser Gly 
                405                 410                 415     

Ala Val Phe Thr Gly Asp Leu Glu Arg Gly Ile Arg Val Ala Gln Arg 
            420                 425                 430         

Ile Val Thr Gly Met Ile His Val Asn Asp Gln Thr Val Asn Val Glu 
        435                 440                 445             

Ser Asn Val Pro Phe Gly Gly Glu Lys Ala Ser Gly Ile Gly Arg Tyr 
    450                 455                 460                 

Cys Gly Glu Trp Gly Ile Glu Glu Phe Thr Thr Leu Lys Trp Ile Ser 
465                 470                 475                 480 

Val Gln Lys Glu Pro Arg Val Tyr Pro Phe Ser 
                485                 490     

<210>   1047
<211>   491
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1038

<400>   1047
Met Ser Ser Thr Thr Ser Val Lys Tyr Ala Gln Trp Asn Lys Leu Tyr 
                5                   10                  15      

Leu Gly Gly Glu Trp Arg Ser Gly Thr Ser Ser Arg Thr Val Thr Val 
            20                  25                  30          

Arg Asn Pro Tyr Asn Gln Glu Val Leu Ala Asp Phe Pro Leu Ala Ser 
        35                  40                  45              

Val Glu Asp Ile Asp Gln Ala Tyr Arg Lys Ala Gln Ala Ala Gln Gln 
    50                  55                  60                  

Gly Trp Ala Glu Glu Ser Ala Phe Thr Arg Ala Glu Val Met Glu Arg 
65                  70                  75                  80  

Ala Ala Ser Ile Leu Ala Gln Arg Lys Asp Glu Ile Val Arg Tyr Leu 
                85                  90                  95      

Val Glu Glu Thr Gly Ser Ser Gln Leu Lys Ala Ser Ile Glu Val Asp 
            100                 105                 110         

Ala Ser Ile Gly Asp Ile Lys Leu Ala Ala Glu Tyr Ala His Lys Met 
        115                 120                 125             

Thr Ala Val Ile Leu Pro Ser Ala Ile Pro Gly Lys Glu Asn Arg Val 
    130                 135                 140                 

Tyr Arg Thr Pro Val Gly Val Val Gly Ala Ile Thr Pro Trp Asn Trp 
145                 150                 155                 160 

Pro Phe Tyr Leu Ser Ile Arg Val Val Ala Pro Ala Leu Ala Thr Gly 
                165                 170                 175     

Asn Ala Ile Val Leu Lys Ala Asp Ser Gln Thr Pro Ile Thr Gly Gly 
            180                 185                 190         

Leu Leu Val Ala Asp Leu Phe Glu Gln Ala Gly Leu Pro Pro Gly Leu 
        195                 200                 205             

Leu Ser Val Val Val Ala Asp Leu Asp Glu Ile Gly Asp Ala Met Val 
    210                 215                 220                 

Glu His Pro Val Pro Arg Val Ile Ser Phe Thr Gly Ser Thr Ala Ala 
225                 230                 235                 240 

Gly Arg His Ile Ala Glu Val Ala Ala Arg Ser Leu Arg Lys Val Ala 
                245                 250                 255     

Leu Glu Leu Gly Gly Asn Asn Val Phe Ile Val Leu Asp Asp Ala Asp 
            260                 265                 270         

Val Asp Gln Ala Val Ala Ala Ala Ala Phe Gly Lys Tyr Leu His Gln 
        275                 280                 285             

Gly Gln Ile Cys Ile Ala Thr Asn Arg Met Ile Val His Arg Lys Val 
    290                 295                 300                 

Tyr Asp Glu Phe Val Glu Lys Phe Met Ala Ala Thr Glu Lys Val Lys 
305                 310                 315                 320 

Val Gly Asp Pro Ala Asp Pro Glu Thr Val Ile Cys Pro Leu Ile Asn 
                325                 330                 335     

Glu Arg Gln Ala Lys Arg Ile Met Gly Leu Ile Asp Glu Ser Leu Lys 
            340                 345                 350         

Met Gly Ala Arg Leu Val Leu Glu Gly Lys Leu Glu Gly Leu Leu Met 
        355                 360                 365             

Tyr Pro Tyr Ile Leu Ala Asp Val Thr Asn Asp Met Pro Ile Ala Lys 
    370                 375                 380                 

Asn Glu Ile Phe Gly Pro Val Ala Ala Ile Leu Pro Val Asp Ser Glu 
385                 390                 395                 400 

Glu Glu Ala Val Asn Ile Ala Asn Glu Ser Asp Tyr Gly Leu Ser Gly 
                405                 410                 415     

Ala Val Phe Thr Gly Asp Leu Glu Arg Gly Ile Arg Val Ala Gln Arg 
            420                 425                 430         

Ile Val Thr Gly Met Ile His Val Asn Asp Gln Thr Val Asn Val Glu 
        435                 440                 445             

Ser Asn Val Pro Phe Gly Gly Glu Lys Ala Ser Gly Ile Gly Arg Tyr 
    450                 455                 460                 

Cys Gly Glu Trp Gly Ile Glu Glu Phe Thr Thr Leu Lys Trp Ile Ser 
465                 470                 475                 480 

Val Gln Lys Glu Pro Arg Val Tyr Pro Phe Ser 
                485                 490     

<210>   1048
<211>   491
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1038

<400>   1048
Met Ser Ser Thr Thr Ser Val Lys Tyr Ala Gln Trp Asn Lys Leu Tyr 
                5                   10                  15      

Leu Gly Gly Glu Trp Arg Ser Gly Thr Ser Ser Arg Thr Val Thr Val 
            20                  25                  30          

Arg Asn Pro Tyr Asn Gln Glu Val Leu Ala Glu Phe Pro Leu Ala Ser 
        35                  40                  45              

Val Glu Asp Ile Asp Gln Ala Tyr Arg Lys Ala Gln Ala Ala Gln Gln 
    50                  55                  60                  

Gly Trp Ala Glu Glu Ser Ala Phe Thr Arg Ala Glu Val Met Glu Arg 
65                  70                  75                  80  

Ala Ala Ser Ile Leu Ala Gln Arg Lys Asp Glu Ile Val Arg Tyr Leu 
                85                  90                  95      

Val Glu Glu Thr Gly Ser Ser Gln Leu Lys Ala Ser Ile Glu Val Asp 
            100                 105                 110         

Ala Ser Ile Gly Asp Ile Lys Leu Ala Ala Glu Tyr Ala His Lys Met 
        115                 120                 125             

Thr Ala Val Ile Leu Pro Ser Ala Ile Pro Gly Lys Glu Asn Arg Val 
    130                 135                 140                 

Tyr Arg Thr Pro Val Gly Val Val Gly Ala Ile Thr Pro Trp Asn Trp 
145                 150                 155                 160 

Pro Phe Tyr Leu Ser Ile Arg Val Val Ala Pro Ala Leu Ala Thr Gly 
                165                 170                 175     

Asn Ala Ile Val Leu Lys Ala Asp Ser Gln Thr Pro Ile Thr Gly Gly 
            180                 185                 190         

Leu Leu Val Ala Asp Leu Phe Glu Gln Ala Gly Leu Pro Pro Gly Leu 
        195                 200                 205             

Leu Ser Val Val Val Ala Asp Leu Asp Glu Ile Gly Asp Ala Met Val 
    210                 215                 220                 

Glu His Pro Val Pro Arg Val Ile Ser Phe Thr Gly Ser Thr Ala Ala 
225                 230                 235                 240 

Gly Arg His Ile Ala Glu Val Ala Ala Arg Ser Leu Arg Lys Val Ala 
                245                 250                 255     

Leu Glu Leu Gly Gly Asn Asn Val Phe Ile Val Leu Asp Asp Ala Asp 
            260                 265                 270         

Val Asp Gln Ala Val Ala Ala Ala Ala Phe Gly Lys Tyr Leu His Gln 
        275                 280                 285             

Gly Gln Ile Cys Ile Ala Thr Asn Arg Met Ile Val His Arg Lys Val 
    290                 295                 300                 

Tyr Asp Glu Phe Val Glu Lys Phe Met Ala Ala Thr Glu Lys Val Lys 
305                 310                 315                 320 

Val Gly Asp Pro Ala Asp Pro Glu Thr Val Ile Cys Pro Leu Ile Asn 
                325                 330                 335     

Glu Arg Gln Ala Lys Arg Ile Met Gly Leu Ile Asp Glu Ser Leu Lys 
            340                 345                 350         

Met Gly Ala Arg Leu Val Leu Glu Gly Lys Leu Glu Gly Leu Leu Met 
        355                 360                 365             

Tyr Pro Tyr Ile Leu Ala Asp Val Thr Asn Asp Met Pro Ile Ala Lys 
    370                 375                 380                 

Asn Glu Ile Phe Gly Pro Val Ala Ala Ile Leu Pro Val Asp Ser Glu 
385                 390                 395                 400 

Glu Glu Ala Val Asn Ile Ala Asn Glu Ser Asp Tyr Gly Leu Ser Gly 
                405                 410                 415     

Ala Val Phe Thr Gly Asp Leu Glu Arg Gly Ile Arg Val Ala Gln Arg 
            420                 425                 430         

Ile Val Thr Gly Met Ile His Val Asn Asp Gln Thr Val Asn Val Glu 
        435                 440                 445             

Ser Asn Val Pro Phe Gly Gly Glu Lys Ala Ser Gly Ile Gly Arg Tyr 
    450                 455                 460                 

Cys Gly Glu Trp Gly Ile Glu Glu Phe Thr Thr Leu Lys Trp Ile Ser 
465                 470                 475                 480 

Val Gln Lys Glu Pro Arg Ile Tyr Pro Phe Ser 
                485                 490     

<210>   1049
<211>   491
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1038

<400>   1049
Met Ser Ser Thr Thr Ser Val Lys Tyr Ala Gln Trp Asn Lys Leu Tyr 
                5                   10                  15      

Leu Gly Gly Glu Trp Arg Ser Gly Thr Ser Ser Arg Thr Val Thr Val 
            20                  25                  30          

Arg Asn Pro Tyr Asn Gln Glu Val Leu Ala Glu Phe Pro Leu Ala Ser 
        35                  40                  45              

Val Glu Asp Ile Asp Gln Ala Tyr Arg Lys Ala Gln Ala Ala Gln Gln 
    50                  55                  60                  

Gly Trp Ala Glu Glu Ser Ala Phe Thr Arg Ala Glu Val Met Glu Arg 
65                  70                  75                  80  

Ala Ala Ser Ile Leu Ala Gln Arg Lys Asp Glu Ile Val Arg Tyr Leu 
                85                  90                  95      

Val Glu Glu Thr Gly Ser Ser Gln Leu Lys Ala Ser Ile Glu Val Asp 
            100                 105                 110         

Ala Ser Ile Gly Asp Ile Lys Leu Ala Ala Glu Tyr Ala His Lys Met 
        115                 120                 125             

Thr Ala Val Ile Leu Pro Ser Ala Ile Pro Gly Lys Glu Asn Arg Val 
    130                 135                 140                 

Tyr Arg Thr Pro Val Gly Val Val Gly Ala Ile Thr Pro Trp Asn Trp 
145                 150                 155                 160 

Pro Phe Tyr Leu Ser Ile Arg Val Val Ala Pro Ala Leu Ala Thr Gly 
                165                 170                 175     

Asn Ala Ile Val Leu Lys Ala Asp Ser Gln Thr Pro Ile Thr Gly Gly 
            180                 185                 190         

Leu Leu Val Ala Asp Leu Phe Glu Gln Ala Gly Leu Pro Pro Gly Leu 
        195                 200                 205             

Leu Ser Val Val Val Ala Asp Leu Asp Glu Ile Gly Asp Ala Met Val 
    210                 215                 220                 

Glu His Pro Val Pro Arg Val Ile Ser Phe Thr Gly Ser Thr Ala Ala 
225                 230                 235                 240 

Gly Arg His Ile Ala Glu Val Ala Ala Arg Ser Leu Arg Lys Val Ala 
                245                 250                 255     

Leu Glu Leu Gly Gly Asn Asn Val Phe Ile Val Leu Asp Asp Ala Asp 
            260                 265                 270         

Val Asp Gln Ala Val Ala Ala Ala Ala Phe Gly Lys Tyr Leu His Gln 
        275                 280                 285             

Gly Gln Ile Cys Ile Ala Thr Asn Arg Met Ile Val His Arg Lys Val 
    290                 295                 300                 

Tyr Asp Glu Phe Val Glu Lys Phe Met Ala Ala Thr Glu Lys Val Lys 
305                 310                 315                 320 

Val Gly Asp Pro Ala Asp Pro Glu Thr Val Ile Cys Pro Leu Ile Asn 
                325                 330                 335     

Glu Arg Gln Ala Lys Arg Ile Met Gly Leu Ile Asp Glu Ser Leu Lys 
            340                 345                 350         

Met Gly Ala Arg Leu Val Leu Glu Gly Lys Leu Glu Gly Leu Leu Met 
        355                 360                 365             

Tyr Pro Tyr Ile Leu Ala Asp Val Thr Asn Asp Met Pro Ile Ala Lys 
    370                 375                 380                 

Asn Glu Ile Phe Gly Pro Val Ala Ala Ile Leu Pro Val Asp Ser Glu 
385                 390                 395                 400 

Glu Glu Ala Val Asn Ile Ala Asn Glu Ser Asp Tyr Gly Leu Ser Gly 
                405                 410                 415     

Ala Val Phe Thr Gly Asp Ile Glu Arg Gly Ile Arg Val Ala Gln Arg 
            420                 425                 430         

Ile Val Thr Gly Met Ile His Val Asn Asp Gln Thr Val Asn Val Glu 
        435                 440                 445             

Ser Asn Val Pro Phe Gly Gly Glu Lys Ala Ser Gly Ile Gly Arg Tyr 
    450                 455                 460                 

Cys Gly Glu Trp Gly Ile Glu Glu Phe Thr Thr Leu Lys Trp Ile Ser 
465                 470                 475                 480 

Val Gln Lys Glu Pro Arg Val Tyr Pro Phe Ser 
                485                 490     

<210>   1050
<211>   1476
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1039

<400>   1050
gtgtcgagca caacatcggt gaagtacgct caatggaaca aattgtatct tgggggagag       60

tggaggtctg ggacgagcag cagaacggtg acggttcgca atccatacaa tcaggaggtc      120

ctcgcggaat ttccgctggc atcggtggaa gacatcgatc aggcctatcg aaaggcccag      180

gccgcacagc aaggatgggc tgaggatagt gcgttcactc gcgccgaggt gatggagcgc      240

gcagctagta ttctcgcgca gcggaaggat gaaatcgtcc ggtacttggt cgaggaaacg      300

ggaagttctc aactcaaggc gagcatcgaa gtggatgctt ccatcggcga catcaagttg      360

gccgccgagt atgcgcacaa aatgacggcg gtgatcctcc cttccgcgat tcccggcaag      420

gagaatcgcg tgtatcgcac tcccgtcgga gtcgtgggcg ccatcacacc gtggaattgg      480

ccgttttatc tgagtatccg cgtggtggcg ccagcgcttg cgacggggaa cgccatcgtc      540

ctcaaggcag attctcagac gcccatcacc ggcggactcc ttgtcgcgga tctgtttgag      600

caggcagggc ttccaccagg gctcttgagt gtggtggtgg ccgatctcga cgagatcgga      660

gacgcgatgg tcgaacatcc ggttccccgg gtgatctcgt tcacagggtc cacagcggca      720

ggtcggcata tcgctgaggt cgcggcgcga tcgctgcgca aggtggcgct cgaactcggc      780

gggaacaacg tgttcattgt gctcgacgat gcggacgtcg accaggcggt tgccgcggcg      840

gcgttcggga aatatcttca ccaaggccag atctgcatcg caacaaaccg catgattgtc      900

catcgcaagg tgtacgacga gtttgtcgag aagttcatgg cagcgaccga aaaggtgaag      960

gtcggcgatc cggcagaccc cgagacggtg atttgcccgc tcatcaacga gcgccaggca     1020

aaacggatca tggggctcat cgacgagagc ttgaagatgg gggcacgcct ggtcttggag     1080

ggaaagctcg aagggctgct tatgtatcca tacatcctgg cggatgtgac taacgacatg     1140

cccatcgcga aaaacgagat cttcggcccg gtcgcggcca ttctgcccgt ggatagcgag     1200

gaggaggccg tgaacatcgc aaacgagtcg gactatggac tgtccggggc agtgtttacg     1260

ggagatcttg agcgcggcat ccgagtcgcc cagcgcattg tcacagggat gattcacgtc     1320

aatgaccaaa cggtcaatgt ggagtccaat gttccatttg gtggagaaaa ggcttccggc     1380

atcggccgtt attgtggaga gtggggcatt gaggagttca ccacgttgaa gtggatttcc     1440

gtgcagaaag agccgagagt gtatccgttt tcgtaa                               1476


<210>   1051
<211>   1476
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1039

<400>   1051
gtgtcgagca caacatcggt gaagtacgct caatggaaca aattgtatct tgggggagag       60

tggaggtctg ggacgagcag caaaacggtg acggttcgca atccatacaa tcaggaggtc      120

ctcgcggaat ttccgctggc atcggtggaa gacatcgatc aggcctatcg aaaggcccag      180

gccgcacagc aaggatgggc tgaggagagt gcgttcactc gcgccgaggt gatggagcgc      240

gcagctagta ttctcgcgca gcggaaggat gaaatcgtcc ggtacttggt cgaggaaacg      300

ggaagttctc aactcaaggc gagcatcgaa gtggatgctt ccatcggcga catcaagttg      360

gccgccgagt atgcgcacaa aatgacggcg gtgatcctcc cttccgcgat tcccggcaag      420

gagaatcgcg tgtatcgcac tcccgtcgga gtcgtgggcg ccatcacacc gtggaattgg      480

ccgttttatc tgagtatccg cgtggtggcg ccagcgcttg cgacggggaa cgccatcgtc      540

ctcaaggcag attctcagac gcccatcacc ggcggactcc ttgtcgcgga tctgtttgag      600

caggcagggc ttccaccagg gctcttgagt gtggtggtgg ccgatctcga cgagatcgga      660

gacgcgatgg tcgaacatcc ggttccccgg gtgatctcgt tcacagggtc cacagcggca      720

ggtcggcata tcgctgaggt cgcggcgcga tcgctgcgca aggtggcgct cgaactcggc      780

gggaacaacg tgttcattgt gctcgacgat gcggacgtcg accaggcggt tgccgcggcg      840

gcgttcggga aatatcttca ccaaggccag atctgcatcg caacaaaccg catgattgtc      900

catcgcaagg tgtacgacga gtttgtcgag aagttcatgg cagcgaccga aaaggtgaag      960

gtcggcgatc cggcagaccc cgagacggtg atttgcccgc tcatcaacga gcgccaggca     1020

aaacggatca tggggctcat cgacgagagc ttgaagatgg gggcacgcct ggtcttggag     1080

ggaaagctcg aagggctgct tatgtatcca tacatcctgg cggatgtgac taacgacatg     1140

cccatcgcga aaaacgagat cttcggcccg gtcgcggcca ttctgcccgt ggatagcgag     1200

gaggaggccg tgaacatcgc aaacgagtcg gactatggac tgtccggggc agtgtttacg     1260

ggagatcttg agcgcggcat ccgagtcgcc cagcgcattg tcacagggat gattcacgtc     1320

aatgaccaaa cggtcaatgt ggagtccaat gttccatttg gtggagaaaa ggcttccggc     1380

atcggccgtt attgtggaga gtggggcatt gaggagttca ccacgttgaa gtggatttcc     1440

gtgcagaaag agccgagagt gtatccgttt tcgtaa                               1476


<210>   1052
<211>   1476
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1039

<400>   1052
gtgtcgagca caacatcggt gaagtacgct caatggaaca aattgtatct tgggggagag       60

tggaggtctg ggacgagcag cagaacggtg acggttcgca atccatacaa tcaggaggtc      120

ctcgcggatt ttccgctggc atcggtggaa gacatcgatc aggcctatcg aaaggcccag      180

gccgcacagc aaggatgggc tgaggagagt gcgttcactc gcgccgaggt gatggagcgc      240

gcagctagta ttctcgcgca gcggaaggat gaaatcgtcc ggtacttggt cgaggaaacg      300

ggaagttctc aactcaaggc gagcatcgaa gtggatgctt ccatcggcga catcaagttg      360

gccgccgagt atgcgcacaa aatgacggcg gtgatcctcc cttccgcgat tcccggcaag      420

gagaatcgcg tgtatcgcac tcccgtcgga gtcgtgggcg ccatcacacc gtggaattgg      480

ccgttttatc tgagtatccg cgtggtggcg ccagcgcttg cgacggggaa cgccatcgtc      540

ctcaaggcag attctcagac gcccatcacc ggcggactcc ttgtcgcgga tctgtttgag      600

caggcagggc ttccaccagg gctcttgagt gtggtggtgg ccgatctcga cgagatcgga      660

gacgcgatgg tcgaacatcc ggttccccgg gtgatctcgt tcacagggtc cacagcggca      720

ggtcggcata tcgctgaggt cgcggcgcga tcgctgcgca aggtggcgct cgaactcggc      780

gggaacaacg tgttcattgt gctcgacgat gcggacgtcg accaggcggt tgccgcggcg      840

gcgttcggga aatatcttca ccaaggccag atctgcatcg caacaaaccg catgattgtc      900

catcgcaagg tgtacgacga gtttgtcgag aagttcatgg cagcgaccga aaaggtgaag      960

gtcggcgatc cggcagaccc cgagacggtg atttgcccgc tcatcaacga gcgccaggca     1020

aaacggatca tggggctcat cgacgagagc ttgaagatgg gggcacgcct ggtcttggag     1080

ggaaagctcg aagggctgct tatgtatcca tacatcctgg cggatgtgac taacgacatg     1140

cccatcgcga aaaacgagat cttcggcccg gtcgcggcca ttctgcccgt ggatagcgag     1200

gaggaggccg tgaacatcgc aaacgagtcg gactatggac tgtccggggc agtgtttacg     1260

ggagatcttg agcgcggcat ccgagtcgcc cagcgcattg tcacagggat gattcacgtc     1320

aatgaccaaa cggtcaatgt ggagtccaat gttccatttg gtggagaaaa ggcttccggc     1380

atcggccgtt attgtggaga gtggggcatt gaggagttca ccacgttgaa gtggatttcc     1440

gtgcagaaag agccgagagt gtatccgttt tcgtaa                               1476


<210>   1053
<211>   1476
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1039

<400>   1053
gtgtcgagca caacatcggt gaagtacgct caatggaaca aattgtatct tgggggagag       60

tggaggtctg ggacgagcag cagaacggtg acggttcgca atccatacaa tcaggaggtc      120

ctcgcggaat ttccgctggc atcggtggaa gacatcgatc aggcctatcg aaaggcccag      180

gccgcacagc aaggatgggc tgaggagagt gcgttcactc gcgccgaggt gatggagcgc      240

gcagctagta ttctcgcgca gcggaaggat gaaatcgtcc ggtacttggt cgaggaaacg      300

ggaagttctc aactcaaggc gagcatcgaa gtggatgctt ccatcggcga catcaagttg      360

gccgccgagt atgcgcacaa aatgacggcg gtgatcctcc cttccgcgat tcccggcaag      420

gagaatcgcg tgtatcgcac tcccgtcgga gtcgtgggcg ccatcacacc gtggaattgg      480

ccgttttatc tgagtatccg cgtggtggcg ccagcgcttg cgacggggaa cgccatcgtc      540

ctcaaggcag attctcagac gcccatcacc ggcggactcc ttgtcgcgga tctgtttgag      600

caggcagggc ttccaccagg gctcttgagt gtggtggtgg ccgatctcga cgagatcgga      660

gacgcgatgg tcgaacatcc ggttccccgg gtgatctcgt tcacagggtc cacagcggca      720

ggtcggcata tcgctgaggt cgcggcgcga tcgctgcgca aggtggcgct cgaactcggc      780

gggaacaacg tgttcattgt gctcgacgat gcggacgtcg accaggcggt tgccgcggcg      840

gcgttcggga aatatcttca ccaaggccag atctgcatcg caacaaaccg catgattgtc      900

catcgcaagg tgtacgacga gtttgtcgag aagttcatgg cagcgaccga aaaggtgaag      960

gtcggcgatc cggcagaccc cgagacggtg atttgcccgc tcatcaacga gcgccaggca     1020

aaacggatca tggggctcat cgacgagagc ttgaagatgg gggcacgcct ggtcttggag     1080

ggaaagctcg aagggctgct tatgtatcca tacatcctgg cggatgtgac taacgacatg     1140

cccatcgcga aaaacgagat cttcggcccg gtcgcggcca ttctgcccgt ggatagcgag     1200

gaggaggccg tgaacatcgc aaacgagtcg gactatggac tgtccggggc agtgtttacg     1260

ggagatcttg agcgcggcat ccgagtcgcc cagcgcattg tcacagggat gattcacgtc     1320

aatgaccaaa cggtcaatgt ggagtccaat gttccatttg gtggagaaaa ggcttccggc     1380

atcggccgtt attgtggaga gtggggcatt gaggagttca ccacgttgaa gtggatttcc     1440

gtgcagaaag agccgagaat ttatccgttt tcgtaa                               1476


<210>   1054
<211>   1476
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1039

<400>   1054
gtgtcgagca caacatcggt gaagtacgct caatggaaca aattgtatct tgggggagag       60

tggaggtctg ggacgagcag cagaacggtg acggttcgca atccatacaa tcaggaggtc      120

ctcgcggaat ttccgctggc atcggtggaa gacatcgatc aggcctatcg aaaggcccag      180

gccgcacagc aaggatgggc tgaggagagt gcgttcactc gcgccgaggt gatggagcgc      240

gcagctagta ttctcgcgca gcggaaggat gaaatcgtcc ggtacttggt cgaggaaacg      300

ggaagttctc aactcaaggc gagcatcgaa gtggatgctt ccatcggcga catcaagttg      360

gccgccgagt atgcgcacaa aatgacggcg gtgatcctcc cttccgcgat tcccggcaag      420

gagaatcgcg tgtatcgcac tcccgtcgga gtcgtgggcg ccatcacacc gtggaattgg      480

ccgttttatc tgagtatccg cgtggtggcg ccagcgcttg cgacggggaa cgccatcgtc      540

ctcaaggcag attctcagac gcccatcacc ggcggactcc ttgtcgcgga tctgtttgag      600

caggcagggc ttccaccagg gctcttgagt gtggtggtgg ccgatctcga cgagatcgga      660

gacgcgatgg tcgaacatcc ggttccccgg gtgatctcgt tcacagggtc cacagcggca      720

ggtcggcata tcgctgaggt cgcggcgcga tcgctgcgca aggtggcgct cgaactcggc      780

gggaacaacg tgttcattgt gctcgacgat gcggacgtcg accaggcggt tgccgcggcg      840

gcgttcggga aatatcttca ccaaggccag atctgcatcg caacaaaccg catgattgtc      900

catcgcaagg tgtacgacga gtttgtcgag aagttcatgg cagcgaccga aaaggtgaag      960

gtcggcgatc cggcagaccc cgagacggtg atttgcccgc tcatcaacga gcgccaggca     1020

aaacggatca tggggctcat cgacgagagc ttgaagatgg gggcacgcct ggtcttggag     1080

ggaaagctcg aagggctgct tatgtatcca tacatcctgg cggatgtgac taacgacatg     1140

cccatcgcga aaaacgagat cttcggcccg gtcgcggcca ttctgcccgt ggatagcgag     1200

gaggaggccg tgaacatcgc aaacgagtcg gactatggac tgtccggggc agtgtttacg     1260

ggagatattg agcgcggcat ccgagtcgcc cagcgcattg tcacagggat gattcacgtc     1320

aatgaccaaa cggtcaatgt ggagtccaat gttccatttg gtggagaaaa ggcttccggc     1380

atcggccgtt attgtggaga gtggggcatt gaggagttca ccacgttgaa gtggatttcc     1440

gtgcagaaag agccgagagt gtatccgttt tcgtaa                               1476


<210>   1055
<211>   311
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1055
Met Leu Glu Arg Lys Lys Ile Ser Val Ile Gly Ala Gly Phe Thr Gly 
                5                   10                  15      

Ala Thr Thr Ala Phe Leu Leu Ala Ala Lys Glu Leu Gly Asp Val Val 
            20                  25                  30          

Leu Leu Asp Ile Pro Ser Leu Glu Asn Pro Thr Lys Gly Lys Ala Leu 
        35                  40                  45              

Asp Met Leu Glu Ala Met Pro Val Leu Gly Ser Asp Ala Arg Val Val 
    50                  55                  60                  

Gly Thr Ser Asn Tyr Glu Asp Thr Ala Gly Ser Asp Leu Val Ile Ile 
65                  70                  75                  80  

Thr Ala Gly Leu Pro Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val 
                85                  90                  95      

Asn Thr Asn Ala Asn Ile Val Lys Ser Val Thr Glu Gln Val Val Arg 
            100                 105                 110         

His Ser Pro Asp Ala Cys Leu Ile Val Leu Ser Asn Pro Val Asp Ala 
        115                 120                 125             

Met Thr Tyr Val Ala Tyr Lys Thr Ser Gly Phe Pro Lys Gln Arg Val 
    130                 135                 140                 

Ile Gly Gln Ala Gly Val Leu Asp Thr Ala Arg Phe Asn Thr Phe Val 
145                 150                 155                 160 

Ala Met Glu Leu Gly Val Ser Val Glu Asp Val His Gly Phe Val Leu 
                165                 170                 175     

Gly Val His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ala Asn Val 
            180                 185                 190         

Gly Gly Val Pro Leu Glu Lys Leu Leu Pro Lys Glu Arg Ile Asp Ala 
        195                 200                 205             

Ile Val Glu Arg Thr Arg Asn Gly Gly Gly Glu Ile Val Ser Leu Met 
    210                 215                 220                 

Gly Asn Ala Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Leu Gln Met 
225                 230                 235                 240 

Ala Glu Ser Ile Leu Lys Asp Lys Arg Arg Val Leu Pro Ala Ile Ala 
                245                 250                 255     

Tyr Leu Glu Gly Glu Tyr Gly Tyr Arg Asp Leu Thr Leu Gly Val Pro 
            260                 265                 270         

Thr Val Leu Gly Lys Gly Gly Ile Glu Arg Ile Leu Glu Leu Glu Leu 
        275                 280                 285             

Leu Pro Glu Glu Lys Ala Ala Leu Asp Lys Ser Ala Glu Ser Val Arg 
    290                 295                 300                 

Arg Leu Ile Ser Val Leu Ser 
305                 310     

<210>   1056
<211>   936
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1056
atgttggaga ggaagaagat ctcggtgatc ggcgccggat tcacgggcgc caccacagcg       60

tttttgctgg cggccaagga gcttggagac gtggtcctct tggacatccc gtcgctcgag      120

aatcccacca aaggcaaggc gctcgacatg ctcgaggcta tgcctgtgct cgggagcgac      180

gctcgcgtcg tggggacttc caattacgag gacacggccg gatcggacct cgtcatcatc      240

acggcaggac tgccgcgcaa gcccgggatg agccgggacg atctcgtcaa tacgaacgcg      300

aacatcgtga agtcggtcac cgagcaggtg gtccggcact cgccggacgc ctgtctcatc      360

gtcctctcca accctgtgga cgccatgacg tacgtggcgt acaagacgag cggatttccg      420

aagcagcgcg tcatcggtca ggccggcgtg ctcgacacgg cccgcttcaa cacgttcgtg      480

gccatggagc tcggcgtgtc ggtcgaagac gtgcacggct tcgtcctcgg cgtgcacggc      540

gacgacatgg tgccgctcgt ccgctatgcg aacgtcggcg gcgtgccgct cgagaagctg      600

ctcccgaagg agcggattga cgccatcgtc gagcgcaccc ggaacggtgg gggcgaaatt      660

gtcagcctga tgggcaacgc gagcgcgtat tacgccccgg ccgcatcgct tctgcagatg      720

gcggagtcca tcctcaagga taagcggcgc gtgttgcccg ccatcgcgta tctcgaaggg      780

gagtacggct atcgagatct cacgctcggc gttccgacgg tgctcggcaa aggcggcatc      840

gagcgcatcc tggagctgga gcttttgccg gaggaaaagg cggcgctcga caaatcggcc      900

gaatccgtgc gcaggctgat ctccgtcctc tcgtga                                936


<210>   1057
<211>   308
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   1057
Arg Lys Lys Val Ser Val Ile Gly Ala Gly Phe Thr Gly Ala Thr Thr 
                5                   10                  15      

Ala Phe Leu Ile Ala Gln Lys Glu Leu Ala Asp Val Val Leu Val Asp 
            20                  25                  30          

Ile Pro Gln Leu Glu Asn Pro Thr Lys Gly Lys Ala Leu Asp Met Leu 
        35                  40                  45              

Glu Ala Ser Pro Val Gln Gly Phe Asp Ala Lys Ile Thr Gly Thr Ser 
    50                  55                  60                  

Asn Tyr Glu Asp Thr Ala Gly Ser Asp Ile Val Val Ile Thr Ala Gly 
65                  70                  75                  80  

Ile Ala Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val Ser Thr Asn 
                85                  90                  95      

Glu Lys Ile Met Arg Ser Val Thr Gln Glu Ile Val Lys Tyr Ser Pro 
            100                 105                 110         

Asp Ser Ile Ile Val Val Leu Thr Asn Pro Val Asp Ala Met Thr Tyr 
        115                 120                 125             

Ala Val Tyr Lys Glu Ser Gly Phe Pro Lys Glu Arg Val Ile Gly Gln 
    130                 135                 140                 

Ser Gly Val Leu Asp Thr Ala Arg Phe Arg Thr Phe Val Ala Glu Glu 
145                 150                 155                 160 

Leu Asn Leu Ser Val Lys Asp Val Thr Gly Phe Val Leu Gly Gly His 
                165                 170                 175     

Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ser Tyr Ala Gly Gly Ile 
            180                 185                 190         

Pro Leu Glu Thr Leu Ile Pro Lys Glu Arg Ile Asp Ala Ile Val Glu 
        195                 200                 205             

Arg Thr Arg Lys Gly Gly Gly Glu Ile Val Asn Leu Leu Gly Asn Gly 
    210                 215                 220                 

Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Thr Glu Met Val Glu Ala 
225                 230                 235                 240 

Ile Leu Lys Asp Gln Arg Arg Val Leu Pro Thr Ile Ala Tyr Leu Glu 
                245                 250                 255     

Gly Glu Tyr Gly Tyr Glu Gly Ile Tyr Leu Gly Val Pro Thr Ile Val 
            260                 265                 270         

Gly Gly Asn Gly Leu Glu Gln Ile Ile Glu Leu Glu Leu Thr Asp Tyr 
        275                 280                 285             

Glu Arg Ala Gln Leu Asn Lys Ser Val Glu Ser Val Lys Asn Val Met 
    290                 295                 300                 

Lys Val Leu Ser 
305             

<210>   1058
<211>   309
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   1058
Ile Lys Arg Arg Lys Ile Thr Val Val Gly Gly Gly Phe Thr Gly Thr 
                5                   10                  15      

Thr Thr Ala Leu Met Thr Ala Gln Lys Glu Leu Gly Asp Val Val Leu 
            20                  25                  30          

Ile Asp Ile Pro Lys Met Glu Asp Pro Thr Lys Gly Lys Ala Leu Asp 
        35                  40                  45              

Met Met Glu Ala Ser Pro Val Gln Gly Phe Asp Ser Lys Ile Thr Gly 
    50                  55                  60                  

Thr Ser Asp Tyr Lys Asp Thr Ala Gly Ser Asp Ile Val Val Ile Thr 
65                  70                  75                  80  

Ala Gly Ile Pro Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val Ser 
                85                  90                  95      

Thr Asn Ala Gly Ile Met Lys Ser Val Thr Gln Glu Ile Val Lys Tyr 
            100                 105                 110         

Ser Pro Asp Cys Tyr Ile Ile Val Leu Thr Asn Pro Val Asp Ala Met 
        115                 120                 125             

Thr Tyr Thr Val Phe Lys Glu Ser Gly Phe Pro Lys Asn Arg Val Ile 
    130                 135                 140                 

Gly Gln Ser Gly Val Leu Asp Thr Ala Arg Phe Asn Thr Phe Val Ala 
145                 150                 155                 160 

Glu Glu Leu Asn Val Ser Val Glu Asp Val Thr Gly Phe Val Leu Gly 
                165                 170                 175     

Gly His Gly Asp Asp Met Val Pro Met Leu Arg Tyr Ser Phe Ala Gly 
            180                 185                 190         

Gly Ile Pro Leu Glu Lys Leu Ile Asp Lys Glu Arg Leu Glu Ala Ile 
        195                 200                 205             

Val Glu Arg Thr Arg Lys Gly Gly Gly Glu Ile Val Asn Leu Leu Gly 
    210                 215                 220                 

Asn Gly Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Ile Val Gln Met Val 
225                 230                 235                 240 

Glu Ala Ile Leu Lys Asp Lys Lys Arg Ile Leu Pro Thr Ile Ala Tyr 
                245                 250                 255     

Leu Glu Gly Glu Tyr Gly Tyr Ser Asp Leu Tyr Leu Gly Val Pro Thr 
            260                 265                 270         

Val Ile Gly Gly Asp Gly Ile Glu Gln Val Phe Glu Leu Asp Leu Asn 
        275                 280                 285             

Asp Asp Glu Lys Ala Ala Leu Asp Lys Ser Val Ala Ser Val Lys Lys 
    290                 295                 300                 

Val Met Glu Ile Leu 
305                 

<210>   1059
<211>   309
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   1059
Leu Lys Arg Lys Lys Ile Ser Val Ile Gly Ser Gly Phe Thr Gly Ala 
                5                   10                  15      

Thr Thr Ala Leu Met Val Ala Gln Lys Glu Leu Gly Asp Val Val Leu 
            20                  25                  30          

Val Asp Ile Pro Asp Met Glu Asp Pro Thr Lys Gly Lys Ala Leu Asp 
        35                  40                  45              

Met Ala Glu Ala Ala Pro Val Gln Gly Phe Asp Ala Lys Ile Thr Gly 
    50                  55                  60                  

Thr Ser Asn Tyr Ala Asp Thr Glu Gly Ser Asp Leu Val Ile Ile Thr 
65                  70                  75                  80  

Ala Gly Ile Ala Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val Asn 
                85                  90                  95      

Thr Asn Ala Asn Ile Met Lys Ser Val Thr Lys Glu Ile Val His Tyr 
            100                 105                 110         

Ser Pro Asn Thr Thr Ile Val Val Leu Thr Asn Pro Val Asp Ala Met 
        115                 120                 125             

Thr Tyr Thr Val Phe Lys Glu Ser Gly Leu Pro Lys Glu Arg Val Ile 
    130                 135                 140                 

Gly Gln Ser Gly Ile Leu Asp Thr Ala Arg Phe Arg Thr Phe Val Ala 
145                 150                 155                 160 

Glu Glu Leu Asn Leu Ser Val Lys Asp Val Thr Gly Phe Val Leu Gly 
                165                 170                 175     

Gly His Gly Asp Asp Met Val Pro Leu Ile Arg Tyr Ser Tyr Ala Gly 
            180                 185                 190         

Gly Ile Pro Leu Glu Lys Leu Ile Pro Gln Glu Arg Leu Asp Ala Ile 
        195                 200                 205             

Val Gln Arg Thr Arg Thr Gly Gly Gly Glu Ile Val Asn Leu Leu Gly 
    210                 215                 220                 

Asn Gly Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Thr Val Met Ala 
225                 230                 235                 240 

Glu Ala Ile Leu Lys Asp Gln Arg Arg Val Leu Pro Thr Ile Ala Tyr 
                245                 250                 255     

Leu Glu Gly Glu Tyr Gly Tyr Gln Asp Ile Tyr Leu Gly Val Pro Thr 
            260                 265                 270         

Ile Leu Gly Gly Glu Gly Ile Glu Glu Ile Ile Glu Leu Asp Leu Thr 
        275                 280                 285             

Lys Glu Glu Lys Ala Gln Leu Asp Lys Ser Ala Asp Ser Val Lys Asn 
    290                 295                 300                 

Val Leu Asn Val Leu 
305                 

<210>   1060
<211>   309
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1060
Lys Arg Asn Lys Val Ser Val Ile Gly Ala Gly Phe Thr Gly Ala Thr 
                5                   10                  15      

Thr Ala Phe Leu Thr Ala Gln Lys Glu Leu Ala Asp Val Val Leu Val 
            20                  25                  30          

Asp Ile Pro Gln Leu Glu Asn Pro Thr Lys Gly Lys Ala Leu Asp Met 
        35                  40                  45              

Leu Glu Ala Ser Pro Val Gln Gly Phe Asp Ala Asn Ile Thr Gly Thr 
    50                  55                  60                  

Ala Asn Tyr Glu Asp Thr Ala Gly Ser Asp Ile Val Val Ile Thr Ala 
65                  70                  75                  80  

Gly Ile Ala Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val Ala Thr 
                85                  90                  95      

Asn Glu Lys Ile Met Arg Ser Val Thr Lys Glu Val Val Lys Tyr Ser 
            100                 105                 110         

Pro Asp Cys Ile Ile Ile Val Leu Thr Asn Pro Val Asp Ala Met Thr 
        115                 120                 125             

Tyr Ala Val Tyr Lys Glu Ser Gly Phe Pro Lys Glu Arg Val Ile Gly 
    130                 135                 140                 

Gln Ser Gly Ile Leu Asp Thr Ala Arg Phe Arg Thr Phe Val Ala Gln 
145                 150                 155                 160 

Glu Leu Asn Leu Ser Val Lys Asp Ile Thr Gly Phe Val Leu Gly Gly 
                165                 170                 175     

His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ser Tyr Ala Gly Gly 
            180                 185                 190         

Ile Pro Leu Glu Thr Leu Leu Pro Lys Asp Arg Ile Asp Ala Ile Val 
        195                 200                 205             

Glu Arg Thr Arg Lys Gly Gly Gly Glu Ile Val Asn Leu Leu Gly Asn 
    210                 215                 220                 

Gly Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Thr Glu Met Val Glu 
225                 230                 235                 240 

Ala Ile Leu Lys Asp Gln Arg Arg Val Leu Pro Thr Ile Ala Tyr Leu 
                245                 250                 255     

Glu Gly Glu Tyr Gly Tyr Glu Gly Ile Tyr Leu Gly Val Pro Thr Ile 
            260                 265                 270         

Ile Gly Gly Asn Gly Leu Glu Gln Ile Ile Glu Leu Glu Leu Thr Glu 
        275                 280                 285             

Thr Glu Lys Ser Gln Leu Asp Lys Ser Val Glu Ser Val Lys Asn Val 
    290                 295                 300                 

Met Lys Val Leu Ser 
305                 

<210>   1061
<211>   309
<212>   PRT
<213>   Bacillus israeli

<400>   1061
Ile Lys Arg Lys Lys Ile Ser Val Ile Gly Ala Gly Phe Thr Gly Ala 
                5                   10                  15      

Thr Thr Ala Phe Leu Leu Ala Lys Lys Glu Leu Gly Asp Val Val Leu 
            20                  25                  30          

Val Asp Ile Pro Gln Ala Glu Asn Pro Thr Lys Gly Lys Ala Leu Asp 
        35                  40                  45              

Met Leu Glu Ser Ser Pro Val Leu Gly Phe Asp Ala Asn Ile Ile Gly 
    50                  55                  60                  

Thr Ser Asn Tyr Glu Glu Thr Ala Asp Ser Asp Ile Val Val Ile Thr 
65                  70                  75                  80  

Ala Gly Ile Ala Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val Gln 
                85                  90                  95      

Thr Asn Gln Lys Val Met Lys Ser Val Thr Lys Glu Val Val Lys Tyr 
            100                 105                 110         

Ser Pro Asn Ser Ile Ile Ile Val Leu Thr Asn Pro Val Asp Ala Met 
        115                 120                 125             

Thr Tyr Thr Val Tyr Lys Glu Ser Gly Phe Pro Lys His Arg Val Ile 
    130                 135                 140                 

Gly Gln Ser Gly Val Leu Asp Thr Ala Arg Phe Arg Thr Phe Val Ala 
145                 150                 155                 160 

Gln Glu Leu Asn Leu Ser Val Lys Asp Ile Thr Gly Phe Val Leu Gly 
                165                 170                 175     

Gly His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ser Tyr Ala Gly 
            180                 185                 190         

Gly Ile Pro Leu Glu Lys Leu Ile Pro Lys Glu Arg Leu Glu Ala Ile 
        195                 200                 205             

Val Glu Arg Thr Arg Lys Gly Gly Gly Glu Ile Val Asn Leu Leu Gly 
    210                 215                 220                 

Asn Gly Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Val Glu Met Val 
225                 230                 235                 240 

Glu Ala Ile Val Lys Asp Gln Arg Arg Val Leu Pro Ala Ile Ala Tyr 
                245                 250                 255     

Leu Glu Gly Glu Tyr Gly Phe Glu Gly Ile Tyr Leu Gly Val Pro Thr 
            260                 265                 270         

Ile Leu Gly Gly Asn Gly Leu Glu Gln Ile Ile Glu Leu Glu Leu Thr 
        275                 280                 285             

Asp Glu Glu Lys Ala Ala Leu Glu Lys Ser Ala Glu Ser Val Arg Asn 
    290                 295                 300                 

Val Met Lys Ala Leu 
305                 

<210>   1062
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1055

<400>   1062
Met Leu Glu Arg Lys Lys Ile Ser Val Ile Gly Ala Gly Phe Thr Gly 
                5                   10                  15      

Ala Thr Thr Ala Phe Leu Leu Ala Ala Lys Glu Leu Gly Asp Val Val 
            20                  25                  30          

Leu Leu Asp Ile Pro Ser Leu Glu Asn Pro Thr Lys Gly Lys Ala Leu 
        35                  40                  45              

Asp Met Leu Glu Ala Met Pro Val Leu Gly Ser Asp Ala Arg Val Val 
    50                  55                  60                  

Gly Thr Ser Asn Tyr Glu Asp Thr Ala Gly Ser Asp Leu Val Ile Ile 
65                  70                  75                  80  

Thr Ala Gly Leu Pro Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val 
                85                  90                  95      

Gln Thr Asn Ala Asn Ile Val Lys Ser Val Thr Glu Gln Val Val Arg 
            100                 105                 110         

His Ser Pro Asp Ala Cys Leu Ile Val Leu Ser Asn Pro Val Asp Ala 
        115                 120                 125             

Met Thr Tyr Val Ala Tyr Lys Thr Ser Gly Phe Pro Lys Gln Arg Val 
    130                 135                 140                 

Ile Gly Gln Ala Gly Val Leu Asp Thr Ala Arg Phe Asn Thr Phe Val 
145                 150                 155                 160 

Ala Met Glu Leu Gly Val Ser Val Glu Asp Val His Gly Phe Val Leu 
                165                 170                 175     

Gly Val His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ala Asn Val 
            180                 185                 190         

Gly Gly Val Pro Leu Glu Lys Leu Leu Pro Lys Glu Arg Ile Asp Ala 
        195                 200                 205             

Ile Val Glu Arg Thr Arg Asn Gly Gly Gly Glu Ile Val Ser Leu Met 
    210                 215                 220                 

Gly Asn Ala Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Leu Gln Met 
225                 230                 235                 240 

Ala Glu Ser Ile Leu Lys Asp Lys Arg Arg Val Leu Pro Ala Ile Ala 
                245                 250                 255     

Tyr Leu Glu Gly Glu Tyr Gly Tyr Arg Asp Leu Thr Leu Gly Val Pro 
            260                 265                 270         

Thr Val Leu Gly Lys Gly Gly Ile Glu Arg Ile Leu Glu Leu Glu Leu 
        275                 280                 285             

Leu Pro Glu Glu Lys Ala Ala Leu Asp Lys Ser Ala Glu Ser Val Arg 
    290                 295                 300                 

Arg Leu Ile Ser Val Leu Ser 
305                 310     

<210>   1063
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1055

<400>   1063
Met Leu Glu Arg Lys Lys Ile Ser Val Ile Gly Ala Gly Phe Thr Gly 
                5                   10                  15      

Ala Thr Thr Ala Phe Leu Leu Ala Ala Lys Glu Leu Gly Asp Val Val 
            20                  25                  30          

Leu Leu Asp Ile Pro Ser Leu Glu Asn Pro Thr Lys Gly Lys Ala Leu 
        35                  40                  45              

Asp Met Leu Glu Ala Met Pro Val Leu Gly Ser Asp Ala Arg Val Val 
    50                  55                  60                  

Gly Thr Ser Asn Tyr Glu Asp Thr Ala Gly Ser Asp Leu Val Ile Ile 
65                  70                  75                  80  

Thr Ala Gly Leu Pro Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val 
                85                  90                  95      

Asn Thr Asn Ala Gln Ile Val Lys Ser Val Thr Glu Gln Val Val Arg 
            100                 105                 110         

His Ser Pro Asp Ala Cys Leu Ile Val Leu Ser Asn Pro Val Asp Ala 
        115                 120                 125             

Met Thr Tyr Val Ala Tyr Lys Thr Ser Gly Phe Pro Lys Gln Arg Val 
    130                 135                 140                 

Ile Gly Gln Ala Gly Val Leu Asp Thr Ala Arg Phe Asn Thr Phe Val 
145                 150                 155                 160 

Ala Met Glu Leu Gly Val Ser Val Glu Asp Val His Gly Phe Val Leu 
                165                 170                 175     

Gly Val His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ala Asn Val 
            180                 185                 190         

Gly Gly Val Pro Leu Glu Lys Leu Leu Pro Lys Glu Arg Ile Asp Ala 
        195                 200                 205             

Ile Val Glu Arg Thr Arg Asn Gly Gly Gly Glu Ile Val Ser Leu Met 
    210                 215                 220                 

Gly Asn Ala Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Leu Gln Met 
225                 230                 235                 240 

Ala Glu Ser Ile Leu Lys Asp Lys Arg Arg Val Leu Pro Ala Ile Ala 
                245                 250                 255     

Tyr Leu Glu Gly Glu Tyr Gly Tyr Arg Asp Leu Thr Leu Gly Val Pro 
            260                 265                 270         

Thr Val Leu Gly Lys Gly Gly Ile Glu Arg Ile Leu Glu Leu Glu Leu 
        275                 280                 285             

Leu Pro Glu Glu Lys Ala Ala Leu Asp Lys Ser Ala Glu Ser Val Arg 
    290                 295                 300                 

Arg Leu Ile Ser Val Leu Ser 
305                 310     

<210>   1064
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1055

<400>   1064
Met Leu Glu Arg Lys Lys Ile Ser Val Ile Gly Ala Gly Phe Thr Gly 
                5                   10                  15      

Ala Thr Thr Ala Phe Leu Leu Ala Ala Lys Glu Leu Gly Asp Val Val 
            20                  25                  30          

Leu Leu Asp Ile Pro Ser Leu Glu Asn Pro Thr Lys Gly Lys Ala Leu 
        35                  40                  45              

Asp Met Leu Glu Ala Met Pro Val Leu Gly Ser Asp Ala Arg Val Val 
    50                  55                  60                  

Gly Thr Ser Asn Tyr Glu Asp Thr Ala Gly Ser Asp Leu Val Ile Ile 
65                  70                  75                  80  

Thr Ala Gly Leu Pro Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val 
                85                  90                  95      

Asn Thr Asn Ala Asn Ile Val Lys Ser Val Thr Glu Gln Val Val Arg 
            100                 105                 110         

His Ser Pro Asp Ala Cys Leu Ile Val Leu Ser Asn Pro Val Asp Ala 
        115                 120                 125             

Met Thr Tyr Val Ala Tyr Lys Thr Ser Gly Phe Pro Lys Gln Arg Val 
    130                 135                 140                 

Ile Gly Gln Ala Gly Val Leu Asp Thr Ala Arg Phe Asn Thr Phe Val 
145                 150                 155                 160 

Ala Met Glu Leu Gly Val Ser Val Glu Asp Val His Gly Phe Val Leu 
                165                 170                 175     

Gly Val His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ala Asn Val 
            180                 185                 190         

Gly Gly Val Pro Leu Glu Lys Leu Leu Pro Lys Glu Arg Ile Asp Ala 
        195                 200                 205             

Ile Val Glu Arg Thr Arg Asn Gly Gly Gly Glu Ile Val Ser Leu Met 
    210                 215                 220                 

Gly Asn Ala Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Leu Gln Met 
225                 230                 235                 240 

Ala Glu Ser Ile Leu Lys Asp Lys Arg Arg Val Leu Pro Ala Ile Ala 
                245                 250                 255     

Tyr Leu Glu Gly Glu Tyr Gly Tyr Arg Asp Leu Thr Leu Gly Val Pro 
            260                 265                 270         

Thr Val Leu Gly Lys Gly Gly Ile Glu Arg Ile Leu Glu Leu Glu Leu 
        275                 280                 285             

Leu Pro Asp Glu Lys Ala Ala Leu Asp Lys Ser Ala Glu Ser Val Arg 
    290                 295                 300                 

Arg Leu Ile Ser Val Leu Ser 
305                 310     

<210>   1065
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1055

<400>   1065
Met Leu Glu Arg Lys Lys Ile Ser Val Ile Gly Ala Gly Phe Thr Gly 
                5                   10                  15      

Ala Thr Thr Ala Phe Leu Leu Ala Ala Lys Glu Leu Gly Asp Val Val 
            20                  25                  30          

Leu Leu Asp Ile Pro Ser Leu Glu Asn Pro Thr Lys Gly Lys Ala Leu 
        35                  40                  45              

Asp Met Leu Glu Ala Met Pro Val Leu Gly Ser Asp Ala Arg Val Val 
    50                  55                  60                  

Gly Thr Ser Asn Tyr Glu Asp Thr Ala Gly Ser Asp Leu Val Ile Ile 
65                  70                  75                  80  

Thr Ala Gly Leu Pro Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val 
                85                  90                  95      

Asn Thr Asn Ala Asn Ile Val Lys Ser Val Thr Glu Gln Val Val Arg 
            100                 105                 110         

His Ser Pro Asp Ala Cys Leu Ile Val Leu Ser Asn Pro Val Asp Ala 
        115                 120                 125             

Met Thr Tyr Val Ala Tyr Lys Thr Ser Gly Phe Pro Lys Gln Arg Val 
    130                 135                 140                 

Ile Gly Gln Ala Gly Val Leu Asp Thr Ala Arg Phe Asn Thr Phe Val 
145                 150                 155                 160 

Ala Met Glu Leu Gly Val Ser Val Glu Asp Val His Gly Phe Val Leu 
                165                 170                 175     

Gly Val His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ala Asn Val 
            180                 185                 190         

Gly Gly Val Pro Leu Glu Lys Leu Leu Pro Lys Glu Arg Ile Asp Ala 
        195                 200                 205             

Ile Val Glu Arg Thr Arg Asn Gly Gly Gly Glu Ile Val Ser Leu Met 
    210                 215                 220                 

Gly Asn Ala Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Leu Gln Met 
225                 230                 235                 240 

Ala Glu Ser Ile Leu Lys Asp Lys Arg Arg Val Leu Pro Ala Ile Ala 
                245                 250                 255     

Tyr Leu Glu Gly Glu Tyr Gly Tyr Arg Asp Leu Thr Leu Gly Val Pro 
            260                 265                 270         

Thr Val Leu Gly Lys Gly Gly Ile Glu Arg Ile Leu Glu Leu Glu Leu 
        275                 280                 285             

Leu Pro Glu Glu Lys Ala Ala Leu Asp Lys Ser Ala Glu Ser Val Arg 
    290                 295                 300                 

Arg Leu Ile Ser Ile Leu Ser 
305                 310     

<210>   1066
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1055

<400>   1066
Met Leu Glu Arg Lys Lys Ile Ser Val Ile Gly Ala Gly Phe Thr Gly 
                5                   10                  15      

Ala Thr Thr Ala Phe Leu Ile Ala Ala Lys Glu Leu Gly Asp Val Val 
            20                  25                  30          

Leu Leu Asp Ile Pro Ser Leu Glu Asn Pro Thr Lys Gly Lys Ala Leu 
        35                  40                  45              

Asp Met Leu Glu Ala Met Pro Val Leu Gly Ser Asp Ala Arg Val Val 
    50                  55                  60                  

Gly Thr Ser Asn Tyr Glu Asp Thr Ala Gly Ser Asp Leu Val Ile Ile 
65                  70                  75                  80  

Thr Ala Gly Leu Pro Arg Lys Pro Gly Met Ser Arg Asp Asp Leu Val 
                85                  90                  95      

Asn Thr Asn Ala Asn Ile Val Lys Ser Val Thr Glu Gln Val Val Arg 
            100                 105                 110         

His Ser Pro Asp Ala Cys Leu Ile Val Leu Ser Asn Pro Val Asp Ala 
        115                 120                 125             

Met Thr Tyr Val Ala Tyr Lys Thr Ser Gly Phe Pro Lys Gln Arg Val 
    130                 135                 140                 

Ile Gly Gln Ala Gly Val Leu Asp Thr Ala Arg Phe Asn Thr Phe Val 
145                 150                 155                 160 

Ala Met Glu Leu Gly Val Ser Val Glu Asp Val His Gly Phe Val Leu 
                165                 170                 175     

Gly Val His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ala Asn Val 
            180                 185                 190         

Gly Gly Val Pro Leu Glu Lys Leu Leu Pro Lys Glu Arg Ile Asp Ala 
        195                 200                 205             

Ile Val Glu Arg Thr Arg Asn Gly Gly Gly Glu Ile Val Ser Leu Met 
    210                 215                 220                 

Gly Asn Ala Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Leu Gln Met 
225                 230                 235                 240 

Ala Glu Ser Ile Leu Lys Asp Lys Arg Arg Val Leu Pro Ala Ile Ala 
                245                 250                 255     

Tyr Leu Glu Gly Glu Tyr Gly Tyr Arg Asp Leu Thr Leu Gly Val Pro 
            260                 265                 270         

Thr Val Leu Gly Lys Gly Gly Ile Glu Arg Ile Leu Glu Leu Glu Leu 
        275                 280                 285             

Leu Pro Glu Glu Lys Ala Ala Leu Asp Lys Ser Ala Glu Ser Val Arg 
    290                 295                 300                 

Arg Leu Ile Ser Val Leu Ser 
305                 310     

<210>   1067
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1056

<400>   1067
atgttggaga ggaagaagat ctcggtgatc ggcgccggat tcacgggcgc caccacagcg       60

tttttgctgg cggccaagga gcttggagac gtggtcctct tggacatccc gtcgctcgag      120

aatcccacca aaggcaaggc gctcgacatg ctcgaggcta tgcctgtgct cgggagcgac      180

gctcgcgtcg tggggacttc caattacgag gacacggccg gatcggacct cgtcatcatc      240

acggcaggac tgccgcgcaa gcccgggatg agccgggacg atctcgtcca aacgaacgcg      300

aacatcgtga agtcggtcac cgagcaggtg gtccggcact cgccggacgc ctgtctcatc      360

gtcctctcca accctgtgga cgccatgacg tacgtggcgt acaagacgag cggatttccg      420

aagcagcgcg tcatcggtca ggccggcgtg ctcgacacgg cccgcttcaa cacgttcgtg      480

gccatggagc tcggcgtgtc ggtcgaagac gtgcacggct tcgtcctcgg cgtgcacggc      540

gacgacatgg tgccgctcgt ccgctatgcg aacgtcggcg gcgtgccgct cgagaagctg      600

ctcccgaagg agcggattga cgccatcgtc gagcgcaccc ggaacggtgg gggcgaaatt      660

gtcagcctga tgggcaacgc gagcgcgtat tacgccccgg ccgcatcgct tctgcagatg      720

gcggagtcca tcctcaagga taagcggcgc gtgttgcccg ccatcgcgta tctcgaaggg      780

gagtacggct atcgagatct cacgctcggc gttccgacgg tgctcggcaa aggcggcatc      840

gagcgcatcc tggagctgga gcttttgccg gaggaaaagg cggcgctcga caaatcggcc      900

gaatccgtgc gcaggctgat ctccgtcctc tcgtga                                936


<210>   1068
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1056

<400>   1068
atgttggaga ggaagaagat ctcggtgatc ggcgccggat tcacgggcgc caccacagcg       60

tttttgctgg cggccaagga gcttggagac gtggtcctct tggacatccc gtcgctcgag      120

aatcccacca aaggcaaggc gctcgacatg ctcgaggcta tgcctgtgct cgggagcgac      180

gctcgcgtcg tggggacttc caattacgag gacacggccg gatcggacct cgtcatcatc      240

acggcaggac tgccgcgcaa gcccgggatg agccgggacg atctcgtcaa tacgaacgcg      300

caaatcgtga agtcggtcac cgagcaggtg gtccggcact cgccggacgc ctgtctcatc      360

gtcctctcca accctgtgga cgccatgacg tacgtggcgt acaagacgag cggatttccg      420

aagcagcgcg tcatcggtca ggccggcgtg ctcgacacgg cccgcttcaa cacgttcgtg      480

gccatggagc tcggcgtgtc ggtcgaagac gtgcacggct tcgtcctcgg cgtgcacggc      540

gacgacatgg tgccgctcgt ccgctatgcg aacgtcggcg gcgtgccgct cgagaagctg      600

ctcccgaagg agcggattga cgccatcgtc gagcgcaccc ggaacggtgg gggcgaaatt      660

gtcagcctga tgggcaacgc gagcgcgtat tacgccccgg ccgcatcgct tctgcagatg      720

gcggagtcca tcctcaagga taagcggcgc gtgttgcccg ccatcgcgta tctcgaaggg      780

gagtacggct atcgagatct cacgctcggc gttccgacgg tgctcggcaa aggcggcatc      840

gagcgcatcc tggagctgga gcttttgccg gaggaaaagg cggcgctcga caaatcggcc      900

gaatccgtgc gcaggctgat ctccgtcctc tcgtga                                936


<210>   1069
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1056

<400>   1069
atgttggaga ggaagaagat ctcggtgatc ggcgccggat tcacgggcgc caccacagcg       60

tttttgctgg cggccaagga gcttggagac gtggtcctct tggacatccc gtcgctcgag      120

aatcccacca aaggcaaggc gctcgacatg ctcgaggcta tgcctgtgct cgggagcgac      180

gctcgcgtcg tggggacttc caattacgag gacacggccg gatcggacct cgtcatcatc      240

acggcaggac tgccgcgcaa gcccgggatg agccgggacg atctcgtcaa tacgaacgcg      300

aacatcgtga agtcggtcac cgagcaggtg gtccggcact cgccggacgc ctgtctcatc      360

gtcctctcca accctgtgga cgccatgacg tacgtggcgt acaagacgag cggatttccg      420

aagcagcgcg tcatcggtca ggccggcgtg ctcgacacgg cccgcttcaa cacgttcgtg      480

gccatggagc tcggcgtgtc ggtcgaagac gtgcacggct tcgtcctcgg cgtgcacggc      540

gacgacatgg tgccgctcgt ccgctatgcg aacgtcggcg gcgtgccgct cgagaagctg      600

ctcccgaagg agcggattga cgccatcgtc gagcgcaccc ggaacggtgg gggcgaaatt      660

gtcagcctga tgggcaacgc gagcgcgtat tacgccccgg ccgcatcgct tctgcagatg      720

gcggagtcca tcctcaagga taagcggcgc gtgttgcccg ccatcgcgta tctcgaaggg      780

gagtacggct atcgagatct cacgctcggc gttccgacgg tgctcggcaa aggcggcatc      840

gagcgcatcc tggagctgga gcttttgccg gatgaaaagg cggcgctcga caaatcggcc      900

gaatccgtgc gcaggctgat ctccgtcctc tcgtga                                936


<210>   1070
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1056

<400>   1070
atgttggaga ggaagaagat ctcggtgatc ggcgccggat tcacgggcgc caccacagcg       60

tttttgctgg cggccaagga gcttggagac gtggtcctct tggacatccc gtcgctcgag      120

aatcccacca aaggcaaggc gctcgacatg ctcgaggcta tgcctgtgct cgggagcgac      180

gctcgcgtcg tggggacttc caattacgag gacacggccg gatcggacct cgtcatcatc      240

acggcaggac tgccgcgcaa gcccgggatg agccgggacg atctcgtcaa tacgaacgcg      300

aacatcgtga agtcggtcac cgagcaggtg gtccggcact cgccggacgc ctgtctcatc      360

gtcctctcca accctgtgga cgccatgacg tacgtggcgt acaagacgag cggatttccg      420

aagcagcgcg tcatcggtca ggccggcgtg ctcgacacgg cccgcttcaa cacgttcgtg      480

gccatggagc tcggcgtgtc ggtcgaagac gtgcacggct tcgtcctcgg cgtgcacggc      540

gacgacatgg tgccgctcgt ccgctatgcg aacgtcggcg gcgtgccgct cgagaagctg      600

ctcccgaagg agcggattga cgccatcgtc gagcgcaccc ggaacggtgg gggcgaaatt      660

gtcagcctga tgggcaacgc gagcgcgtat tacgccccgg ccgcatcgct tctgcagatg      720

gcggagtcca tcctcaagga taagcggcgc gtgttgcccg ccatcgcgta tctcgaaggg      780

gagtacggct atcgagatct cacgctcggc gttccgacgg tgctcggcaa aggcggcatc      840

gagcgcatcc tggagctgga gcttttgccg gaggaaaagg cggcgctcga caaatcggcc      900

gaatccgtgc gcaggctgat ctccattctc tcgtga                                936


<210>   1071
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1056

<400>   1071
atgttggaga ggaagaagat ctcggtgatc ggcgccggat tcacgggcgc caccacagcg       60

tttttgattg cggccaagga gcttggagac gtggtcctct tggacatccc gtcgctcgag      120

aatcccacca aaggcaaggc gctcgacatg ctcgaggcta tgcctgtgct cgggagcgac      180

gctcgcgtcg tggggacttc caattacgag gacacggccg gatcggacct cgtcatcatc      240

acggcaggac tgccgcgcaa gcccgggatg agccgggacg atctcgtcaa tacgaacgcg      300

aacatcgtga agtcggtcac cgagcaggtg gtccggcact cgccggacgc ctgtctcatc      360

gtcctctcca accctgtgga cgccatgacg tacgtggcgt acaagacgag cggatttccg      420

aagcagcgcg tcatcggtca ggccggcgtg ctcgacacgg cccgcttcaa cacgttcgtg      480

gccatggagc tcggcgtgtc ggtcgaagac gtgcacggct tcgtcctcgg cgtgcacggc      540

gacgacatgg tgccgctcgt ccgctatgcg aacgtcggcg gcgtgccgct cgagaagctg      600

ctcccgaagg agcggattga cgccatcgtc gagcgcaccc ggaacggtgg gggcgaaatt      660

gtcagcctga tgggcaacgc gagcgcgtat tacgccccgg ccgcatcgct tctgcagatg      720

gcggagtcca tcctcaagga taagcggcgc gtgttgcccg ccatcgcgta tctcgaaggg      780

gagtacggct atcgagatct cacgctcggc gttccgacgg tgctcggcaa aggcggcatc      840

gagcgcatcc tggagctgga gcttttgccg gaggaaaagg cggcgctcga caaatcggcc      900

gaatccgtgc gcaggctgat ctccgtcctc tcgtga                                936


<210>   1072
<211>   326
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1072
Met Ser Glu Met Val Ser Leu Ala Val Arg Phe Arg Ile Ser Thr Ala 
                5                   10                  15      

Ala Asn Asp Tyr Ile Ile Gln Gly Ile Thr Gln Val Cys Asn Glu Ser 
            20                  25                  30          

Phe His Arg Trp Pro Asp Phe Phe Asn Arg Ala Gln Gly Gly Val Gly 
        35                  40                  45              

Met Gln Phe Phe Lys Met His Ala Leu Gly Asn Asn Tyr Val Phe Val 
    50                  55                  60                  

Asp Thr Ala Arg Thr Thr Leu Pro Thr Asp Asp Leu Pro Ser Leu Ala 
65                  70                  75                  80  

Arg Arg Val Ser Asp Val Arg Arg Gly Ile Gly Ser Asp Gly Leu Ile 
                85                  90                  95      

Leu Val Thr Pro Ser Asp Ser Ala Asp Val Gly Met Arg Ile Trp Asn 
            100                 105                 110         

Ala Asp Gly Ser Glu Ala Glu Ser Cys Gly Asn Gly Leu Arg Cys Val 
        115                 120                 125             

Ala Arg Tyr Ala Tyr Glu Arg Gly Leu Val Asp Ala Thr His Phe Ser 
    130                 135                 140                 

Ile Glu Thr Lys Ala Gly Val Val Ala Ala Gln Val His Leu Asp Val 
145                 150                 155                 160 

Glu Gly Arg Val Arg Leu Val Thr Ile Asp Met Gly Glu Ala Arg Phe 
                165                 170                 175     

Gly Thr Glu Ala Val Pro Tyr Arg Gly Ala Asp Arg Gly Glu Asp Val 
            180                 185                 190         

Arg Val Glu Ala Gly Gly Ala Arg Tyr Thr Gly Thr Leu Val Ser Met 
        195                 200                 205             

Gly Asn Pro His Phe Val Thr Leu Val Asp Arg Val Asp Asp Val Asp 
    210                 215                 220                 

Val Glu Arg Val Gly Arg Val Ile Glu Ser His Pro Asp Phe Pro Glu 
225                 230                 235                 240 

Arg Val Asn Val Glu Phe Val Ser Val Leu Ala Pro Asp Glu Ile Asp 
                245                 250                 255     

Phe Arg Val Tyr Glu Arg Gly Ser Gly Val Thr Phe Ala Cys Gly Thr 
            260                 265                 270         

Gly Ala Cys Ala Ser Val Ala Ala Leu Ala Lys Lys Gly Leu Val Arg 
        275                 280                 285             

Asn Arg Val Thr Val His Leu Leu Gly Gly Asp Leu Asp Ile Glu Ile 
    290                 295                 300                 

Arg Asp Asp Gly His Val Trp Met Thr Gly Glu Ala His Trp Val Cys 
305                 310                 315                 320 

Glu Gly Thr Tyr Tyr Ala 
                325     

<210>   1073
<211>   981
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1073
atgtctgaga tggtttcgct cgcggttcgc tttcgcatca gcaccgcagc gaacgattac       60

attatacaag gaatcacaca ggtttgcaac gaatcatttc atcggtggcc cgattttttc      120

aaccgtgctc aaggaggcgt tggtatgcag ttctttaaga tgcacgcgct cggcaacaac      180

tatgtgtttg tcgatacggc ccggacaacc ctccccacgg acgatctccc gtcgctcgcg      240

cgtcgggtga gcgacgtgcg cagagggatc ggctccgacg gcctcatcct tgtcacgccc      300

tccgacagcg cggatgtcgg catgcggatc tggaatgcgg acggatcgga ggcggaatcc      360

tgcggcaacg gcctgcgctg tgtggccagg tacgcttatg agcgcgggct ggtcgacgcc      420

acgcacttct ccattgaaac caaggcgggc gttgtcgcgg cgcaggtgca tctggacgtc      480

gaggggcgcg tgcggcttgt gaccatcgat atgggcgagg ctcgtttcgg cacggaggcc      540

gtcccctatc gcggggcgga tcgcggtgag gacgtgcgcg tggaggcagg cggcgcgcgc      600

tatacgggca cgctcgtcag catgggcaac ccccactttg tcacgctggt cgatcgcgtc      660

gacgatgtgg acgtcgaacg cgtcgggcgc gtcatcgagt cccatcccga ctttcccgaa      720

cgcgtgaatg tggagtttgt ctcggtgctc gcgccggacg agatcgactt ccgcgtgtac      780

gagcgcggtt cgggcgtgac gttcgcctgc ggcacgggtg cgtgcgcgag tgtggcggcg      840

ctcgccaaaa agggactcgt gcggaaccga gtgacggtgc accttttggg gggcgatctc      900

gacatcgaga ttcgcgacga cggccacgtg tggatgacgg gagaagcgca ctgggtgtgt      960

gaagggacgt attacgcgta g                                                981


<210>   1074
<211>   280
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1074
Met Lys Phe Thr Lys Met His Gly Leu Gly Asn Ser Tyr Ile Tyr Val 
                5                   10                  15      

Asp Cys Phe Lys Glu Leu Leu Lys Glu Glu Glu Leu Pro Ala Leu Ala 
            20                  25                  30          

Val Ala Val Ala Asp Lys Asn Lys Gly Ile Gly Ser Asp Gly Met Ile 
        35                  40                  45              

Leu Ile Cys Pro Ser Asp Arg Ala Pro Val Lys Met Arg Val Phe Asn 
    50                  55                  60                  

Asn Asp Gly Ser Glu Ala Lys Asn Cys Gly Asn Gly Leu Arg Cys Val 
65                  70                  75                  80  

Ala Lys Phe Ala Phe Glu His Gly Tyr Val Lys Glu Thr Ser Phe Asp 
                85                  90                  95      

Val Glu Thr Leu Gly Gly Leu Val Lys Ala Thr Val His Pro Asn Asp 
            100                 105                 110         

Asn Gly Leu Val Asp Thr Val Thr Val Asn Met Gly Glu Pro Arg Leu 
        115                 120                 125             

Gly Arg Ala Gln Ile Pro Met Leu Gly Glu Glu Ala Ala Glu Val Val 
    130                 135                 140                 

Ala Glu Pro Phe Thr Ile Gly Glu Lys Glu Tyr Arg Leu Thr Ala Val 
145                 150                 155                 160 

Ser Met Gly Asn Pro His Ala Ile Met Phe Ile Asp Thr Ile Glu Asp 
                165                 170                 175     

Ala Pro Val Glu Gln Val Gly Pro Leu Leu Glu Lys His Glu Ala Phe 
            180                 185                 190         

Pro Asp Trp Val Asn Val Glu Phe Val Gln Val Val Ser Pro Thr Glu 
        195                 200                 205             

Ile His Phe Arg Val Trp Glu Arg Gly Ser Gly Ile Thr Gln Ala Cys 
    210                 215                 220                 

Gly Thr Gly Ala Cys Ala Ala Val Val Ala Ser Val Leu Asn Gly Phe 
225                 230                 235                 240 

Thr Gln Lys Gly Gln Glu Val Thr Val His Leu Leu Gly Gly Asp Leu 
                245                 250                 255     

Thr Ile Ser Trp Leu Glu Asn Gly Asp Val Leu Met Thr Gly Ala Ala 
            260                 265                 270         

Glu Thr Ile Cys Glu Gly Thr Tyr 
        275                 280 

<210>   1075
<211>   278
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1075
Phe Thr Lys Met His Gly Leu Gly Asn Ser Tyr Ile Tyr Val Asp Leu 
                5                   10                  15      

Phe Arg Glu Thr Leu Pro Glu Glu Asp Leu Pro Ala Ile Ala Arg Ser 
            20                  25                  30          

Val Ala Asp Val His Thr Gly Ile Gly Ser Asp Gly Leu Ile Leu Ile 
        35                  40                  45              

Cys Pro Ser Glu Gln Ala Pro Val Lys Met Arg Ile Phe Asn Ser Asp 
    50                  55                  60                  

Gly Ser Glu Gly Lys Asn Cys Gly Asn Gly Leu Arg Cys Val Ala Lys 
65                  70                  75                  80  

Tyr Ala Tyr Glu His Gly Ile Val Arg Asp Arg Ser Phe Leu Ile Glu 
                85                  90                  95      

Thr Leu Ser Gly Leu Val Glu Ala Glu Val Thr Val Glu Asn Gly Glu 
            100                 105                 110         

Val Thr Ser Val Thr Ile Asp Met Gly Glu Pro Arg Leu Arg Arg Ser 
        115                 120                 125             

Ala Ile Pro Met Thr Gly Pro Glu Ala Glu Gln Val Val Ala Glu Ser 
    130                 135                 140                 

Phe Ala Ile Asp Gly Arg Glu Tyr Glu Ile Thr Ala Val Ser Met Gly 
145                 150                 155                 160 

Asn Pro His Val Ile Phe Tyr Val Asp Asp Ile Glu Lys Ala Pro Val 
                165                 170                 175     

Thr Thr Leu Gly Pro Val Val Glu Lys Asp Ala Arg Phe Pro Glu Gly 
            180                 185                 190         

Val Asn Val Glu Phe Val Glu Val Val Ser Glu Arg Glu Leu His Phe 
        195                 200                 205             

Arg Val Trp Glu Arg Gly Ser Gly Val Thr Gln Ala Cys Gly Thr Gly 
    210                 215                 220                 

Ala Cys Ala Ala Val Val Ala Ser Val Leu Asn Gly Lys Thr Ala Arg 
225                 230                 235                 240 

Gly Val Glu Thr Val Val His Leu Ala Gly Gly Asp Leu Thr Ile Thr 
                245                 250                 255     

Trp Gly His Asp Gly Lys Val Arg Met Thr Gly Pro Ala Glu Thr Val 
            260                 265                 270         

Cys Thr Gly Val Tyr Tyr 
        275             

<210>   1076
<211>   278
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1076
Phe Thr Lys Met His Gly Leu Gly Asn Ser Tyr Ile Tyr Val Asp Leu 
                5                   10                  15      

Phe Arg Glu Thr Leu Pro Glu Glu Glu Leu Pro Ala Ile Ala Arg Ser 
            20                  25                  30          

Val Ala Asp Val His Thr Gly Ile Gly Ser Asp Gly Leu Ile Leu Ile 
        35                  40                  45              

Cys Pro Ser Glu Lys Ala Pro Val Lys Met Arg Ile Phe Asn Ser Asp 
    50                  55                  60                  

Gly Ser Glu Gly Lys Asn Cys Gly Asn Gly Leu Arg Cys Val Ala Lys 
65                  70                  75                  80  

Tyr Ala Tyr Glu His Gly Ile Val Ser Asp Arg Thr Phe Leu Ile Glu 
                85                  90                  95      

Thr Leu Ser Gly Leu Val Glu Ala Arg Val Ala Val Ala Asp Gly Glu 
            100                 105                 110         

Val Thr Ser Val Thr Val Asp Met Gly Glu Pro Arg Leu Glu Arg Ser 
        115                 120                 125             

Ala Ile Pro Met Leu Gly Pro Glu Ala Glu Arg Val Val Ala Glu Pro 
    130                 135                 140                 

Phe Ala Ile Ala Gly Gly Glu Tyr Glu Ile Thr Ala Val Ser Met Gly 
145                 150                 155                 160 

Asn Pro His Val Ile Phe Tyr Val Asp Asp Ile Gln Lys Ala Pro Val 
                165                 170                 175     

Thr Thr Leu Gly Pro Leu Val Glu Lys Asp Pro Arg Phe Pro Glu Gly 
            180                 185                 190         

Val Asn Val Glu Phe Val Glu Val Val Asn Glu Arg Glu Leu His Phe 
        195                 200                 205             

Arg Val Trp Glu Arg Gly Ser Gly Val Thr Gln Ala Cys Gly Thr Gly 
    210                 215                 220                 

Ala Cys Ala Ala Val Val Ala Ser Val Leu Asn Gly Lys Thr Ala Arg 
225                 230                 235                 240 

Gly Glu Glu Thr Val Val His Leu Ala Gly Gly Asp Leu Thr Ile Val 
                245                 250                 255     

Trp Gly His Asp Gly Arg Val Arg Met Thr Gly Pro Ala Glu Thr Val 
            260                 265                 270         

Cys Thr Gly Val Tyr Tyr 
        275             

<210>   1077
<211>   279
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   1077
Gln Phe Thr Lys Met His Gly Leu Gly Asn Asn Tyr Ile Tyr Val Asn 
                5                   10                  15      

Gln Met Lys Glu Gln Leu Pro Glu Glu Lys Leu Ser Glu Ile Ala Ile 
            20                  25                  30          

Gln Val Ser Ser Ile Tyr Thr Gly Ile Gly Ser Asp Gly Met Ile Leu 
        35                  40                  45              

Ile Cys Pro Ser Asp Val Ala Pro Val Lys Met Arg Ile Phe Asn Asn 
    50                  55                  60                  

Asp Gly Ser Glu Gly Lys Asn Cys Gly Asn Gly Leu Arg Cys Val Ala 
65                  70                  75                  80  

Lys Tyr Val Tyr Glu His Gln Ile Val Thr Asp Thr Thr Phe Gln Ile 
                85                  90                  95      

Glu Thr Leu Ser Gly Leu Val Glu Ala Thr Val His Val Gln Asp Asp 
            100                 105                 110         

His Val His Leu Val Thr Val Asp Met Gly Lys Pro Arg Phe Glu Lys 
        115                 120                 125             

Glu Ala Met Pro Met Leu Gly Glu Pro Ala Ser Thr Thr Ile Asn Glu 
    130                 135                 140                 

Pro Leu Asp Phe Gly Thr Thr Thr Leu Asn Gly Thr Ala Val Ser Met 
145                 150                 155                 160 

Gly Asn Pro His Ile Val Phe Tyr Leu Glu Asp Ile Glu Lys Ala Pro 
                165                 170                 175     

Leu Asp Thr Leu Gly Pro Ile Ile Glu Lys His Asp Met Phe Pro Glu 
            180                 185                 190         

Gly Val Asn Val Glu Phe Val Glu Val Val Ser Glu Thr Glu Leu His 
        195                 200                 205             

Phe Arg Val Trp Glu Arg Gly Ser Gly Ile Thr Gln Ala Cys Gly Thr 
    210                 215                 220                 

Gly Ala Cys Ala Ala Ala Val Ser Thr Ile Val Asn Gly Gln Ala Lys 
225                 230                 235                 240 

Lys Glu Thr Asp Met Thr Val His Leu Ala Gly Gly Asp Leu Ile Ile 
                245                 250                 255     

Arg Trp Lys Asp Asn Glu His Val Leu Met Thr Gly Pro Ala Glu Thr 
            260                 265                 270         

Ile Cys Asp Gly Thr Phe Tyr 
        275                 

<210>   1078
<211>   279
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   1078
Arg Phe Thr Lys Met His Gly Leu Gly Asn Ser Tyr Ile Tyr Val Asn 
                5                   10                  15      

Gln Phe Glu Glu Gln Leu Pro Glu Glu Lys Leu Ser Glu Ile Ala Ile 
            20                  25                  30          

Gln Val Ser Ser Val Tyr Thr Gly Ile Gly Ser Asp Gly Met Ile Leu 
        35                  40                  45              

Ile Cys Pro Ser Asp Gln Ala Pro Val Lys Met Arg Ile Phe Asn Asn 
    50                  55                  60                  

Asp Gly Ser Glu Gly Lys Asn Cys Gly Asn Gly Leu Arg Cys Val Ala 
65                  70                  75                  80  

Lys Tyr Ala Tyr Glu His Lys Leu Val Glu Glu Thr Ser Phe Leu Ile 
                85                  90                  95      

Glu Thr Leu Ser Gly Leu Val Lys Ala Glu Val Gln Val Glu Asn Gly 
            100                 105                 110         

Lys Val Asn Val Val Thr Val Asp Met Gly Glu Pro Arg Leu Thr Lys 
        115                 120                 125             

Ser Glu Leu Pro Met Leu Asp Gly Gly Glu Glu His Thr Ile Asn Glu 
    130                 135                 140                 

Thr Met Ala Phe Gly Glu Val Glu Leu Thr Gly Thr Ala Val Ser Met 
145                 150                 155                 160 

Gly Asn Pro His Ile Val Phe Pro Ile Ala Asp Ile Glu Gln Ala Pro 
                165                 170                 175     

Leu Thr Thr Leu Gly Pro Val Ile Glu Lys Asp Pro Arg Phe Pro Glu 
            180                 185                 190         

Gly Ile Asn Val Glu Phe Val Glu Thr Val Asn Glu Gln Glu Leu His 
        195                 200                 205             

Phe Arg Val Trp Glu Arg Gly Ser Gly Ile Thr Gln Ala Cys Gly Thr 
    210                 215                 220                 

Gly Ala Cys Ala Ala Ala Val Ala Ser Val Leu Asn Gly Val Ser Lys 
225                 230                 235                 240 

Arg Asn Gln Asp Ile Thr Val His Leu Ala Gly Gly Asp Leu Val Ile 
                245                 250                 255     

Asn Trp Lys Asp Asn Gly His Val Met Met Thr Gly Pro Ala Glu Thr 
            260                 265                 270         

Val Cys Glu Gly Val Tyr Phe 
        275                 

<210>   1079
<211>   326
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1072

<400>   1079
Met Ser Glu Met Val Ser Leu Ala Val Arg Phe Arg Ile Ser Thr Ala 
                5                   10                  15      

Ala Asn Asp Tyr Ile Ile Gln Gly Ile Thr Gln Val Cys Asn Glu Ser 
            20                  25                  30          

Phe His Arg Trp Pro Asp Phe Phe Asn Arg Ala Gln Gly Gly Val Gly 
        35                  40                  45              

Met Gln Phe Phe Lys Met His Ala Leu Gly Asn Asn Tyr Val Phe Val 
    50                  55                  60                  

Asp Thr Ala Arg Thr Thr Leu Pro Thr Asp Asp Leu Pro Ser Leu Ala 
65                  70                  75                  80  

Arg Arg Val Ser Asp Val Arg Arg Gly Ile Gly Ser Asp Gly Leu Ile 
                85                  90                  95      

Leu Val Thr Pro Ser Asp Ser Ala Asp Val Gly Met Arg Ile Trp Asn 
            100                 105                 110         

Ala Asp Gly Ser Glu Ala Glu Ser Cys Gly Asn Gly Leu Arg Cys Val 
        115                 120                 125             

Ala Arg Tyr Ala Tyr Glu Arg Gly Leu Val Asp Ala Thr His Phe Ser 
    130                 135                 140                 

Ile Glu Thr Lys Ala Gly Val Val Ala Ala Gln Val His Leu Asp Val 
145                 150                 155                 160 

Glu Gly Arg Val Arg Leu Val Thr Ile Asp Met Gly Glu Ala Arg Phe 
                165                 170                 175     

Gly Thr Glu Ala Val Pro Tyr Arg Gly Ala Asp Arg Gly Glu Asp Val 
            180                 185                 190         

Arg Val Glu Ala Gly Gly Ala Arg Tyr Thr Gly Thr Leu Val Ser Met 
        195                 200                 205             

Gly Asn Pro His Phe Val Thr Leu Val Asp Arg Val Asp Asp Val Asp 
    210                 215                 220                 

Val Glu Arg Val Gly Arg Val Ile Glu Ser His Pro Asp Phe Pro Glu 
225                 230                 235                 240 

Arg Val Asn Val Glu Phe Val Ser Val Leu Ala Pro Asp Glu Ile Asp 
                245                 250                 255     

Phe Arg Val Tyr Glu Arg Gly Ser Gly Val Thr Phe Ala Cys Gly Thr 
            260                 265                 270         

Gly Ala Cys Ala Ser Val Ala Ala Leu Ala Arg Lys Gly Leu Val Arg 
        275                 280                 285             

Asn Arg Val Thr Val His Leu Leu Gly Gly Asp Leu Asp Ile Glu Ile 
    290                 295                 300                 

Arg Asp Asp Gly His Val Trp Met Thr Gly Glu Ala His Trp Val Cys 
305                 310                 315                 320 

Glu Gly Thr Tyr Tyr Ala 
                325     

<210>   1080
<211>   326
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1072

<400>   1080
Met Ser Glu Met Val Ser Leu Ala Val Lys Phe Arg Ile Ser Thr Ala 
                5                   10                  15      

Ala Asn Asp Tyr Ile Ile Gln Gly Ile Thr Gln Val Cys Asn Glu Ser 
            20                  25                  30          

Phe His Arg Trp Pro Asp Phe Phe Asn Arg Ala Gln Gly Gly Val Gly 
        35                  40                  45              

Met Gln Phe Phe Lys Met His Ala Leu Gly Asn Asn Tyr Val Phe Val 
    50                  55                  60                  

Asp Thr Ala Arg Thr Thr Leu Pro Thr Asp Asp Leu Pro Ser Leu Ala 
65                  70                  75                  80  

Arg Arg Val Ser Asp Val Arg Arg Gly Ile Gly Ser Asp Gly Leu Ile 
                85                  90                  95      

Leu Val Thr Pro Ser Asp Ser Ala Asp Val Gly Met Arg Ile Trp Asn 
            100                 105                 110         

Ala Asp Gly Ser Glu Ala Glu Ser Cys Gly Asn Gly Leu Arg Cys Val 
        115                 120                 125             

Ala Arg Tyr Ala Tyr Glu Arg Gly Leu Val Asp Ala Thr His Phe Ser 
    130                 135                 140                 

Ile Glu Thr Lys Ala Gly Val Val Ala Ala Gln Val His Leu Asp Val 
145                 150                 155                 160 

Glu Gly Arg Val Arg Leu Val Thr Ile Asp Met Gly Glu Ala Arg Phe 
                165                 170                 175     

Gly Thr Glu Ala Val Pro Tyr Arg Gly Ala Asp Arg Gly Glu Asp Val 
            180                 185                 190         

Arg Val Glu Ala Gly Gly Ala Arg Tyr Thr Gly Thr Leu Val Ser Met 
        195                 200                 205             

Gly Asn Pro His Phe Val Thr Leu Val Asp Arg Val Asp Asp Val Asp 
    210                 215                 220                 

Val Glu Arg Val Gly Arg Val Ile Glu Ser His Pro Asp Phe Pro Glu 
225                 230                 235                 240 

Arg Val Asn Val Glu Phe Val Ser Val Leu Ala Pro Asp Glu Ile Asp 
                245                 250                 255     

Phe Arg Val Tyr Glu Arg Gly Ser Gly Val Thr Phe Ala Cys Gly Thr 
            260                 265                 270         

Gly Ala Cys Ala Ser Val Ala Ala Leu Ala Lys Lys Gly Leu Val Arg 
        275                 280                 285             

Asn Arg Val Thr Val His Leu Leu Gly Gly Asp Leu Asp Ile Glu Ile 
    290                 295                 300                 

Arg Asp Asp Gly His Val Trp Met Thr Gly Glu Ala His Trp Val Cys 
305                 310                 315                 320 

Glu Gly Thr Tyr Tyr Ala 
                325     

<210>   1081
<211>   326
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1072

<400>   1081
Met Ser Glu Met Val Ser Leu Ala Val Arg Phe Arg Ile Ser Thr Ala 
                5                   10                  15      

Ala Asn Asp Tyr Ile Ile Gln Gly Ile Thr Gln Val Cys Asn Glu Ser 
            20                  25                  30          

Phe His Arg Trp Pro Asp Phe Phe Asn Arg Ala Gln Gly Gly Val Gly 
        35                  40                  45              

Met Gln Phe Phe Lys Met His Ala Leu Gly Asn Asn Tyr Val Phe Val 
    50                  55                  60                  

Asp Thr Ala Arg Thr Thr Leu Pro Thr Asp Asp Leu Pro Ser Leu Ala 
65                  70                  75                  80  

Arg Arg Val Ser Asp Val Arg Arg Gly Ile Gly Ser Asp Gly Leu Ile 
                85                  90                  95      

Leu Val Thr Pro Ser Asp Ser Ala Asp Val Gly Met Arg Ile Trp Asn 
            100                 105                 110         

Ala Asp Gly Ser Glu Ala Glu Ser Cys Gly Asn Gly Leu Arg Cys Val 
        115                 120                 125             

Ala Arg Tyr Ala Tyr Glu Arg Gly Leu Val Asp Ala Thr His Phe Ser 
    130                 135                 140                 

Ile Glu Thr Lys Ala Gly Val Val Ala Ala Gln Val His Leu Asp Val 
145                 150                 155                 160 

Glu Gly Arg Val Arg Leu Val Thr Ile Asp Met Gly Glu Ala Arg Phe 
                165                 170                 175     

Gly Thr Glu Ala Val Pro Tyr Arg Gly Ala Asp Arg Gly Glu Asp Val 
            180                 185                 190         

Arg Val Glu Ala Gly Gly Ala Arg Tyr Thr Gly Thr Leu Val Ser Met 
        195                 200                 205             

Gly Asn Pro His Phe Val Thr Leu Val Asp Arg Val Asp Asp Val Asp 
    210                 215                 220                 

Val Glu Arg Val Gly Arg Val Ile Glu Ser His Pro Asp Phe Pro Glu 
225                 230                 235                 240 

Arg Val Asn Val Glu Phe Val Ser Val Leu Ala Pro Asp Glu Ile Asp 
                245                 250                 255     

Phe Arg Val Tyr Glu Arg Gly Ser Gly Val Thr Phe Ala Cys Gly Thr 
            260                 265                 270         

Gly Ala Cys Ala Ser Val Ala Ala Leu Ala Lys Lys Gly Leu Val Lys 
        275                 280                 285             

Asn Arg Val Thr Val His Leu Leu Gly Gly Asp Leu Asp Ile Glu Ile 
    290                 295                 300                 

Arg Asp Asp Gly His Val Trp Met Thr Gly Glu Ala His Trp Val Cys 
305                 310                 315                 320 

Glu Gly Thr Tyr Tyr Ala 
                325     

<210>   1082
<211>   326
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1072

<400>   1082
Met Ser Glu Met Val Ser Leu Ala Val Arg Phe Arg Ile Ser Thr Ala 
                5                   10                  15      

Ala Asn Asp Tyr Ile Ile Gln Gly Ile Thr Gln Val Cys Asn Glu Ser 
            20                  25                  30          

Phe His Arg Trp Pro Asp Phe Phe Asn Arg Ala Gln Gly Gly Val Gly 
        35                  40                  45              

Met Gln Phe Phe Lys Met His Ala Leu Gly Asn Asn Tyr Val Phe Val 
    50                  55                  60                  

Asp Thr Ala Arg Thr Thr Leu Pro Thr Asp Asp Leu Pro Ser Leu Ala 
65                  70                  75                  80  

Arg Arg Val Ser Asp Val Arg Arg Gly Ile Gly Ser Asp Gly Leu Ile 
                85                  90                  95      

Leu Val Thr Pro Ser Asp Ser Ala Asp Val Gly Met Arg Ile Trp Asn 
            100                 105                 110         

Ala Asp Gly Ser Glu Ala Glu Ser Cys Gly Asn Gly Leu Arg Cys Val 
        115                 120                 125             

Ala Arg Tyr Ala Tyr Glu Arg Gly Leu Val Asp Ala Thr His Phe Ser 
    130                 135                 140                 

Ile Glu Thr Lys Ala Gly Val Val Ala Ala Gln Val His Leu Asp Val 
145                 150                 155                 160 

Glu Gly Arg Val Arg Leu Val Thr Ile Asp Met Gly Glu Ala Arg Phe 
                165                 170                 175     

Gly Thr Glu Ala Val Pro Tyr Arg Gly Ala Asp Arg Gly Glu Asp Val 
            180                 185                 190         

Arg Val Glu Ala Gly Gly Ala Arg Tyr Thr Gly Thr Leu Val Ser Met 
        195                 200                 205             

Gly Asn Pro His Phe Val Thr Leu Val Asp Arg Val Asp Asp Val Asp 
    210                 215                 220                 

Val Glu Arg Val Gly Arg Val Ile Glu Ser His Pro Asp Phe Pro Glu 
225                 230                 235                 240 

Arg Val Asn Val Glu Phe Val Ser Val Leu Ala Pro Asp Glu Ile Asp 
                245                 250                 255     

Phe Arg Val Tyr Glu Arg Gly Ser Gly Val Thr Phe Ala Cys Gly Thr 
            260                 265                 270         

Gly Ala Cys Ala Ser Val Ala Ala Leu Ala Lys Lys Gly Ile Val Arg 
        275                 280                 285             

Asn Arg Val Thr Val His Leu Leu Gly Gly Asp Leu Asp Ile Glu Ile 
    290                 295                 300                 

Arg Asp Asp Gly His Val Trp Met Thr Gly Glu Ala His Trp Val Cys 
305                 310                 315                 320 

Glu Gly Thr Tyr Tyr Ala 
                325     

<210>   1083
<211>   326
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1072

<400>   1083
Met Ser Glu Met Ile Ser Leu Ala Val Arg Phe Arg Ile Ser Thr Ala 
                5                   10                  15      

Ala Asn Asp Tyr Ile Ile Gln Gly Ile Thr Gln Val Cys Asn Glu Ser 
            20                  25                  30          

Phe His Arg Trp Pro Asp Phe Phe Asn Arg Ala Gln Gly Gly Val Gly 
        35                  40                  45              

Met Gln Phe Phe Lys Met His Ala Leu Gly Asn Asn Tyr Val Phe Val 
    50                  55                  60                  

Asp Thr Ala Arg Thr Thr Leu Pro Thr Asp Asp Leu Pro Ser Leu Ala 
65                  70                  75                  80  

Arg Arg Val Ser Asp Val Arg Arg Gly Ile Gly Ser Asp Gly Leu Ile 
                85                  90                  95      

Leu Val Thr Pro Ser Asp Ser Ala Asp Val Gly Met Arg Ile Trp Asn 
            100                 105                 110         

Ala Asp Gly Ser Glu Ala Glu Ser Cys Gly Asn Gly Leu Arg Cys Val 
        115                 120                 125             

Ala Arg Tyr Ala Tyr Glu Arg Gly Leu Val Asp Ala Thr His Phe Ser 
    130                 135                 140                 

Ile Glu Thr Lys Ala Gly Val Val Ala Ala Gln Val His Leu Asp Val 
145                 150                 155                 160 

Glu Gly Arg Val Arg Leu Val Thr Ile Asp Met Gly Glu Ala Arg Phe 
                165                 170                 175     

Gly Thr Glu Ala Val Pro Tyr Arg Gly Ala Asp Arg Gly Glu Asp Val 
            180                 185                 190         

Arg Val Glu Ala Gly Gly Ala Arg Tyr Thr Gly Thr Leu Val Ser Met 
        195                 200                 205             

Gly Asn Pro His Phe Val Thr Leu Val Asp Arg Val Asp Asp Val Asp 
    210                 215                 220                 

Val Glu Arg Val Gly Arg Val Ile Glu Ser His Pro Asp Phe Pro Glu 
225                 230                 235                 240 

Arg Val Asn Val Glu Phe Val Ser Val Leu Ala Pro Asp Glu Ile Asp 
                245                 250                 255     

Phe Arg Val Tyr Glu Arg Gly Ser Gly Val Thr Phe Ala Cys Gly Thr 
            260                 265                 270         

Gly Ala Cys Ala Ser Val Ala Ala Leu Ala Lys Lys Gly Leu Val Arg 
        275                 280                 285             

Asn Arg Val Thr Val His Leu Leu Gly Gly Asp Leu Asp Ile Glu Ile 
    290                 295                 300                 

Arg Asp Asp Gly His Val Trp Met Thr Gly Glu Ala His Trp Val Cys 
305                 310                 315                 320 

Glu Gly Thr Tyr Tyr Ala 
                325     

<210>   1084
<211>   981
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1073

<400>   1084
atgtctgaga tggtttcgct cgcggttcgc tttcgcatca gcaccgcagc gaacgattac       60

attatacaag gaatcacaca ggtttgcaac gaatcatttc atcggtggcc cgattttttc      120

aaccgtgctc aaggaggcgt tggtatgcag ttctttaaga tgcacgcgct cggcaacaac      180

tatgtgtttg tcgatacggc ccggacaacc ctccccacgg acgatctccc gtcgctcgcg      240

cgtcgggtga gcgacgtgcg cagagggatc ggctccgacg gcctcatcct tgtcacgccc      300

tccgacagcg cggatgtcgg catgcggatc tggaatgcgg acggatcgga ggcggaatcc      360

tgcggcaacg gcctgcgctg tgtggccagg tacgcttatg agcgcgggct ggtcgacgcc      420

acgcacttct ccattgaaac caaggcgggc gttgtcgcgg cgcaggtgca tctggacgtc      480

gaggggcgcg tgcggcttgt gaccatcgat atgggcgagg ctcgtttcgg cacggaggcc      540

gtcccctatc gcggggcgga tcgcggtgag gacgtgcgcg tggaggcagg cggcgcgcgc      600

tatacgggca cgctcgtcag catgggcaac ccccactttg tcacgctggt cgatcgcgtc      660

gacgatgtgg acgtcgaacg cgtcgggcgc gtcatcgagt cccatcccga ctttcccgaa      720

cgcgtgaatg tggagtttgt ctcggtgctc gcgccggacg agatcgactt ccgcgtgtac      780

gagcgcggtt cgggcgtgac gttcgcctgc ggcacgggtg cgtgcgcgag tgtggcggcg      840

ctcgcccgta agggactcgt gcggaaccga gtgacggtgc accttttggg gggcgatctc      900

gacatcgaga ttcgcgacga cggccacgtg tggatgacgg gagaagcgca ctgggtgtgt      960

gaagggacgt attacgcgta g                                                981


<210>   1085
<211>   981
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1073

<400>   1085
atgtctgaga tggtttcgct cgcggttaaa tttcgcatca gcaccgcagc gaacgattac       60

attatacaag gaatcacaca ggtttgcaac gaatcatttc atcggtggcc cgattttttc      120

aaccgtgctc aaggaggcgt tggtatgcag ttctttaaga tgcacgcgct cggcaacaac      180

tatgtgtttg tcgatacggc ccggacaacc ctccccacgg acgatctccc gtcgctcgcg      240

cgtcgggtga gcgacgtgcg cagagggatc ggctccgacg gcctcatcct tgtcacgccc      300

tccgacagcg cggatgtcgg catgcggatc tggaatgcgg acggatcgga ggcggaatcc      360

tgcggcaacg gcctgcgctg tgtggccagg tacgcttatg agcgcgggct ggtcgacgcc      420

acgcacttct ccattgaaac caaggcgggc gttgtcgcgg cgcaggtgca tctggacgtc      480

gaggggcgcg tgcggcttgt gaccatcgat atgggcgagg ctcgtttcgg cacggaggcc      540

gtcccctatc gcggggcgga tcgcggtgag gacgtgcgcg tggaggcagg cggcgcgcgc      600

tatacgggca cgctcgtcag catgggcaac ccccactttg tcacgctggt cgatcgcgtc      660

gacgatgtgg acgtcgaacg cgtcgggcgc gtcatcgagt cccatcccga ctttcccgaa      720

cgcgtgaatg tggagtttgt ctcggtgctc gcgccggacg agatcgactt ccgcgtgtac      780

gagcgcggtt cgggcgtgac gttcgcctgc ggcacgggtg cgtgcgcgag tgtggcggcg      840

ctcgccaaaa agggactcgt gcggaaccga gtgacggtgc accttttggg gggcgatctc      900

gacatcgaga ttcgcgacga cggccacgtg tggatgacgg gagaagcgca ctgggtgtgt      960

gaagggacgt attacgcgta g                                                981


<210>   1086
<211>   981
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1073

<400>   1086
atgtctgaga tggtttcgct cgcggttcgc tttcgcatca gcaccgcagc gaacgattac       60

attatacaag gaatcacaca ggtttgcaac gaatcatttc atcggtggcc cgattttttc      120

aaccgtgctc aaggaggcgt tggtatgcag ttctttaaga tgcacgcgct cggcaacaac      180

tatgtgtttg tcgatacggc ccggacaacc ctccccacgg acgatctccc gtcgctcgcg      240

cgtcgggtga gcgacgtgcg cagagggatc ggctccgacg gcctcatcct tgtcacgccc      300

tccgacagcg cggatgtcgg catgcggatc tggaatgcgg acggatcgga ggcggaatcc      360

tgcggcaacg gcctgcgctg tgtggccagg tacgcttatg agcgcgggct ggtcgacgcc      420

acgcacttct ccattgaaac caaggcgggc gttgtcgcgg cgcaggtgca tctggacgtc      480

gaggggcgcg tgcggcttgt gaccatcgat atgggcgagg ctcgtttcgg cacggaggcc      540

gtcccctatc gcggggcgga tcgcggtgag gacgtgcgcg tggaggcagg cggcgcgcgc      600

tatacgggca cgctcgtcag catgggcaac ccccactttg tcacgctggt cgatcgcgtc      660

gacgatgtgg acgtcgaacg cgtcgggcgc gtcatcgagt cccatcccga ctttcccgaa      720

cgcgtgaatg tggagtttgt ctcggtgctc gcgccggacg agatcgactt ccgcgtgtac      780

gagcgcggtt cgggcgtgac gttcgcctgc ggcacgggtg cgtgcgcgag tgtggcggcg      840

ctcgccaaaa agggactcgt gaaaaaccga gtgacggtgc accttttggg gggcgatctc      900

gacatcgaga ttcgcgacga cggccacgtg tggatgacgg gagaagcgca ctgggtgtgt      960

gaagggacgt attacgcgta g                                                981


<210>   1087
<211>   981
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1073

<400>   1087
atgtctgaga tggtttcgct cgcggttcgc tttcgcatca gcaccgcagc gaacgattac       60

attatacaag gaatcacaca ggtttgcaac gaatcatttc atcggtggcc cgattttttc      120

aaccgtgctc aaggaggcgt tggtatgcag ttctttaaga tgcacgcgct cggcaacaac      180

tatgtgtttg tcgatacggc ccggacaacc ctccccacgg acgatctccc gtcgctcgcg      240

cgtcgggtga gcgacgtgcg cagagggatc ggctccgacg gcctcatcct tgtcacgccc      300

tccgacagcg cggatgtcgg catgcggatc tggaatgcgg acggatcgga ggcggaatcc      360

tgcggcaacg gcctgcgctg tgtggccagg tacgcttatg agcgcgggct ggtcgacgcc      420

acgcacttct ccattgaaac caaggcgggc gttgtcgcgg cgcaggtgca tctggacgtc      480

gaggggcgcg tgcggcttgt gaccatcgat atgggcgagg ctcgtttcgg cacggaggcc      540

gtcccctatc gcggggcgga tcgcggtgag gacgtgcgcg tggaggcagg cggcgcgcgc      600

tatacgggca cgctcgtcag catgggcaac ccccactttg tcacgctggt cgatcgcgtc      660

gacgatgtgg acgtcgaacg cgtcgggcgc gtcatcgagt cccatcccga ctttcccgaa      720

cgcgtgaatg tggagtttgt ctcggtgctc gcgccggacg agatcgactt ccgcgtgtac      780

gagcgcggtt cgggcgtgac gttcgcctgc ggcacgggtg cgtgcgcgag tgtggcggcg      840

ctcgccaaaa agggaattgt gcggaaccga gtgacggtgc accttttggg gggcgatctc      900

gacatcgaga ttcgcgacga cggccacgtg tggatgacgg gagaagcgca ctgggtgtgt      960

gaagggacgt attacgcgta g                                                981


<210>   1088
<211>   981
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1073

<400>   1088
atgtctgaga tgatttcgct cgcggttcgc tttcgcatca gcaccgcagc gaacgattac       60

attatacaag gaatcacaca ggtttgcaac gaatcatttc atcggtggcc cgattttttc      120

aaccgtgctc aaggaggcgt tggtatgcag ttctttaaga tgcacgcgct cggcaacaac      180

tatgtgtttg tcgatacggc ccggacaacc ctccccacgg acgatctccc gtcgctcgcg      240

cgtcgggtga gcgacgtgcg cagagggatc ggctccgacg gcctcatcct tgtcacgccc      300

tccgacagcg cggatgtcgg catgcggatc tggaatgcgg acggatcgga ggcggaatcc      360

tgcggcaacg gcctgcgctg tgtggccagg tacgcttatg agcgcgggct ggtcgacgcc      420

acgcacttct ccattgaaac caaggcgggc gttgtcgcgg cgcaggtgca tctggacgtc      480

gaggggcgcg tgcggcttgt gaccatcgat atgggcgagg ctcgtttcgg cacggaggcc      540

gtcccctatc gcggggcgga tcgcggtgag gacgtgcgcg tggaggcagg cggcgcgcgc      600

tatacgggca cgctcgtcag catgggcaac ccccactttg tcacgctggt cgatcgcgtc      660

gacgatgtgg acgtcgaacg cgtcgggcgc gtcatcgagt cccatcccga ctttcccgaa      720

cgcgtgaatg tggagtttgt ctcggtgctc gcgccggacg agatcgactt ccgcgtgtac      780

gagcgcggtt cgggcgtgac gttcgcctgc ggcacgggtg cgtgcgcgag tgtggcggcg      840

ctcgccaaaa agggactcgt gcggaaccga gtgacggtgc accttttggg gggcgatctc      900

gacatcgaga ttcgcgacga cggccacgtg tggatgacgg gagaagcgca ctgggtgtgt      960

gaagggacgt attacgcgta g                                                981


<210>   1089
<211>   247
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1089
Met Pro Asn Gly Trp Arg Arg Ala Ser Arg Trp Pro Ala Val Phe Cys 
                5                   10                  15      

Thr Cys Thr Ala Ile Pro Pro Arg Val His Thr Val Phe Ser Phe Gly 
            20                  25                  30          

Gly Leu Lys Gly Gly Thr Gln Val Ala Val Ala Gln Ala Ala Gln His 
        35                  40                  45              

Asn Arg Glu Phe Phe Trp Arg Arg Leu His Thr Leu Ser Gly Val Ile 
    50                  55                  60                  

Pro Val Gly Leu Phe Leu Leu Glu His Leu Phe Thr Asn Ala Thr Ala 
65                  70                  75                  80  

Leu Gly Gly Ala Ala Ala Phe Asn Glu Ala Val Gln Ala Ile Gln Ser 
                85                  90                  95      

Leu Pro Leu Leu His Val Ile Glu Phe Val Phe Ile Phe Leu Pro Ile 
            100                 105                 110         

Thr Tyr His Gly Val Phe Gly Leu Tyr Val Ala Phe Val Ser Gly Tyr 
        115                 120                 125             

Asn Ala Asn Arg Tyr Ser Phe Ser Arg Asn Val Met Phe Val Leu Gln 
    130                 135                 140                 

Arg Val Thr Gly Ile Ile Thr Phe Val Phe Ile Ile Phe His Leu Trp 
145                 150                 155                 160 

Thr Thr Arg Phe Ser Gly Asn Ala Pro Ser Phe Asp Met Val His Glu 
                165                 170                 175     

Leu Val Thr Asp Asn Ala Tyr Phe Ala Phe Met Ile Val Gly Val Ile 
            180                 185                 190         

Ala Ala Thr Phe His Phe Ser Asn Gly Leu Trp Ser Phe Ala Ile His 
        195                 200                 205             

Trp Gly Ile Thr Val Gly Arg Arg Ala Gln Arg Ile Thr Ala Trp Val 
    210                 215                 220                 

Thr Met Ile Met Phe Val Val Leu Ala Ala Val Gly Val Ala Ser Leu 
225                 230                 235                 240 

Ile Ala Phe Arg Met Asn Val 
                245         

<210>   1090
<211>   744
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1090
gtgccaaacg ggtggcggcg tgcgtcgcgc tggcctgcgg tgttttgcac ttgcacggcg       60

atcccgccgc gcgtacatac tgttttctct tttgggggat tgaagggagg aacccaagtg      120

gcagtggccc aagcagccca gcacaaccgg gagtttttct ggcggcggct ccacacgctc      180

tcgggcgtca ttccggtggg actgttcctg ctggagcacc tgttcacgaa cgcgacggcc      240

ctgggcggtg cggcggcttt caacgaagcc gtgcaagcga ttcaatcgct tccgctcctg      300

cacgtcattg agttcgtgtt catcttcctg cccatcacgt atcacggcgt gtttgggctt      360

tacgtggcgt tcgtgtccgg ctacaacgcg aatcggtatt cgttcagccg caacgtgatg      420

ttcgtgttgc agcgggtgac gggcatcatc accttcgtct tcatcatttt ccacctgtgg      480

acgacgcggt tttccggcaa cgcgccgtcg tttgacatgg tgcacgagct cgtcaccgac      540

aatgcgtact tcgcgttcat gatcgtgggc gtgatcgcgg cgacgttcca cttctcgaac      600

ggactgtggt cgttcgccat tcattggggc atcacggttg ggcgccgggc gcagcgcatc      660

accgcgtggg tgacgatgat catgtttgtc gtgctggcgg cggtcggtgt ggcgtcgctg      720

attgcgttcc gcatgaacgt ctga                                             744


<210>   1091
<211>   198
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   1091
Asn Arg Glu Phe Tyr Phe Arg Arg Leu His Ser Leu Leu Gly Val Ile 
                5                   10                  15      

Pro Val Gly Ile Phe Leu Ile Gln His Leu Val Val Asn Gln Phe Ala 
            20                  25                  30          

Ala Arg Gly Ala Glu Ala Phe Asn Ser Ala Ala His Phe Met Asp Ser 
        35                  40                  45              

Leu Pro Phe Arg Tyr Ala Leu Glu Ile Phe Ile Ile Phe Leu Pro Leu 
    50                  55                  60                  

Ile Tyr His Ala Val Tyr Gly Val Tyr Ile Ala Phe Thr Ala Lys Asn 
65                  70                  75                  80  

Asn Ala Gly Gln Tyr Ser Tyr Met Arg Asn Trp Leu Phe Val Leu Gln 
                85                  90                  95      

Arg Val Thr Gly Ile Ile Thr Leu Ile Phe Val Ser Trp His Val Trp 
            100                 105                 110         

Glu Thr Arg Ile Ala Ala Gln Met Gly Ala Glu Val Asn Phe Asp Met 
        115                 120                 125             

Met Ala Asn Ile Leu Ser Ser Pro Ala Met Leu Gly Phe Tyr Ile Val 
    130                 135                 140                 

Gly Val Leu Ser Thr Ile Phe His Phe Ser Asn Gly Leu Trp Ser Phe 
145                 150                 155                 160 

Ala Val Thr Trp Gly Ile Thr Val Thr Pro Arg Ser Gln Arg Ile Ser 
                165                 170                 175     

Thr Tyr Val Thr Leu Ile Ile Phe Val Ala Leu Ser Tyr Val Gly Leu 
            180                 185                 190         

Lys Ala Ile Phe Ala Phe 
        195             

<210>   1092
<211>   198
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1092
Asn Arg Glu Phe Val Tyr Arg Arg Leu His Ser Leu Leu Gly Val Ile 
                5                   10                  15      

Pro Val Gly Ile Phe Leu Ile Gln His Leu Val Val Asn His Phe Ala 
            20                  25                  30          

Ala Ser Gly Glu Glu Ala Phe Asn Asn Ala Ala His Phe Met Glu Asn 
        35                  40                  45              

Leu Pro Phe Arg Tyr Ala Leu Glu Ile Phe Val Ile Phe Leu Pro Leu 
    50                  55                  60                  

Ile Tyr His Ala Val Tyr Gly Val Tyr Ile Ala Phe Thr Ala Lys Asn 
65                  70                  75                  80  

Asn Ala Asn Arg Phe Gly Phe Phe Arg Asn Trp Met Phe Val Leu Gln 
                85                  90                  95      

Arg Ile Thr Gly Ile Ile Thr Leu Ile Phe Val Ser Trp His Val Trp 
            100                 105                 110         

Glu Thr Arg Ile Ala Ala Gln Met Gly Ala Glu Val Asn Phe Asp Met 
        115                 120                 125             

Met Ala Asp Ile Leu Ser Ser Pro Ile Met Leu Gly Phe Tyr Ile Val 
    130                 135                 140                 

Gly Val Leu Ser Thr Ile Phe His Phe Ser Asn Gly Leu Trp Ser Phe 
145                 150                 155                 160 

Ala Val Thr Trp Gly Ile Thr Val Ser Pro Arg Ser Gln Arg Ile Ala 
                165                 170                 175     

Thr Phe Val Thr Met Gly Val Phe Val Val Leu Ser Tyr Val Gly Leu 
            180                 185                 190         

Arg Ala Ile Leu Ala Phe 
        195             

<210>   1093
<211>   198
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   1093
Asn Arg Glu Phe Tyr Phe Arg Arg Leu His Ser Leu Leu Gly Val Ile 
                5                   10                  15      

Pro Val Gly Ile Phe Leu Ile Gln His Leu Val Val Asn Gln Phe Ala 
            20                  25                  30          

Ala Arg Gly Ala Asp Ala Phe Asn Lys Ala Ala Gly Phe Met Asp Ser 
        35                  40                  45              

Leu Pro Phe Arg Tyr Ala Leu Glu Ile Phe Ile Ile Phe Leu Pro Leu 
    50                  55                  60                  

Ile Tyr His Ala Val Tyr Gly Val Tyr Ile Ala Phe Thr Ala Lys Asn 
65                  70                  75                  80  

Asn Ala Gly His Tyr Ser Tyr Phe Arg Asn Trp Met Phe Val Leu Gln 
                85                  90                  95      

Arg Val Thr Gly Ile Leu Thr Leu Ile Phe Val Ser Trp His Val Trp 
            100                 105                 110         

Gln Thr Arg Ile Ala Ala Gln Met Gly Ala Glu Val Asn Phe Asp Met 
        115                 120                 125             

Met Ala Asn Ile Leu Ser Ser Pro Phe Met Leu Gly Phe Tyr Ile Val 
    130                 135                 140                 

Gly Val Leu Ser Val Ile Phe His Phe Ser Asn Gly Leu Trp Ser Phe 
145                 150                 155                 160 

Ala Val Thr Trp Gly Ile Thr Val Thr Pro Arg Ser Gln Arg Ile Ser 
                165                 170                 175     

Thr Tyr Val Thr Leu Ile Ile Phe Leu Ala Leu Ser Tyr Val Gly Leu 
            180                 185                 190         

Lys Ala Ile Phe Ala Phe 
        195             

<210>   1094
<211>   198
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   1094
Asn Arg Glu Phe Phe Asn Arg Arg Leu His Ser Leu Leu Gly Val Ile 
                5                   10                  15      

Pro Val Gly Leu Phe Leu Val Gln His Leu Val Val Asn His Phe Ala 
            20                  25                  30          

Thr Gly Gly Glu Glu Ser Phe Asn Lys Ala Ala His Phe Met Glu Gln 
        35                  40                  45              

Leu Pro Phe Arg Tyr Val Leu Glu Thr Val Val Ile Phe Leu Pro Leu 
    50                  55                  60                  

Leu Phe His Ala Ile Tyr Gly Leu Tyr Ile Ala Phe Thr Ala Lys Asn 
65                  70                  75                  80  

Asn Ala Gly Arg Phe Gly Phe Phe Arg Asn Trp Met Phe Leu Leu Gln 
                85                  90                  95      

Arg Val Ser Gly Val Val Thr Leu Ile Phe Ile Thr Trp His Val Trp 
            100                 105                 110         

Glu Thr Arg Val Ala Ala Ala Phe Gly Ala Asp Val Asn Phe Gln Met 
        115                 120                 125             

Met Glu Asn Ile Leu Ser Asn Pro Phe Met Phe Trp Phe Tyr Ile Val 
    130                 135                 140                 

Gly Val Ile Ser Thr Ile Phe His Phe Ala Asn Gly Leu Trp Ser Phe 
145                 150                 155                 160 

Ala Val Ser Trp Gly Ile Thr Val Thr Pro Arg Ser Gln Leu Ile Ser 
                165                 170                 175     

Thr Tyr Val Thr Ile Ala Ile Phe Ile Ala Leu Ser Ile Val Gly Ile 
            180                 185                 190         

Arg Ala Ile Thr Ala Phe 
        195             

<210>   1095
<211>   198
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1095
Asn Arg Glu Phe Phe Asn Arg Arg Leu His Ser Leu Leu Gly Val Ile 
                5                   10                  15      

Pro Ile Gly Ile Phe Leu Ile Gln His Phe Val Val Asn His Phe Ala 
            20                  25                  30          

Thr Ala Gly Ala Ser Ala Phe Asn Gln Ala Ala His Phe Met Glu Ser 
        35                  40                  45              

Leu Pro Phe Arg Tyr Ala Leu Glu Ile Phe Ile Ile Phe Ile Pro Ile 
    50                  55                  60                  

Leu Tyr His Ala Ile Tyr Gly Leu Tyr Ile Ala Phe Gln Ala Lys Asn 
65                  70                  75                  80  

Asn Thr Ser His Tyr Gly Tyr Phe Arg Asn Trp Met Phe Leu Leu Gln 
                85                  90                  95      

Arg Ile Ser Gly Val Phe Leu Leu Ile Phe Ile Ala Trp His Val Trp 
            100                 105                 110         

Glu Thr Arg Ile Gln Ala Ala Phe Gly Ala Glu Val Asn Tyr Asp Met 
        115                 120                 125             

Met Ala Asp Ile Leu Ser Asn Pro Phe Met Leu Val Phe Tyr Ile Leu 
    130                 135                 140                 

Gly Val Val Ser Ala Thr Phe His Phe Ala Asn Gly Leu Trp Ser Phe 
145                 150                 155                 160 

Phe Val Ser Trp Gly Ile Thr Val Ser Pro Arg Ser Gln Gln Ile Met 
                165                 170                 175     

Thr Tyr Val Thr Val Ala Ile Phe Phe Ala Leu Thr Phe Val Gly Ile 
            180                 185                 190         

Arg Ala Ile Leu Ala Phe 
        195             

<210>   1096
<211>   247
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1089

<400>   1096
Met Pro Asn Gly Trp Arg Arg Ala Ser Arg Trp Pro Ala Val Phe Cys 
                5                   10                  15      

Thr Cys Thr Ala Leu Pro Pro Arg Val His Thr Val Phe Ser Phe Gly 
            20                  25                  30          

Gly Leu Lys Gly Gly Thr Gln Val Ala Val Ala Gln Ala Ala Gln His 
        35                  40                  45              

Asn Arg Glu Phe Phe Trp Arg Arg Leu His Thr Leu Ser Gly Val Ile 
    50                  55                  60                  

Pro Val Gly Leu Phe Leu Leu Glu His Leu Phe Thr Asn Ala Thr Ala 
65                  70                  75                  80  

Leu Gly Gly Ala Ala Ala Phe Asn Glu Ala Val Gln Ala Ile Gln Ser 
                85                  90                  95      

Leu Pro Leu Leu His Val Ile Glu Phe Val Phe Ile Phe Leu Pro Ile 
            100                 105                 110         

Thr Tyr His Gly Val Phe Gly Leu Tyr Val Ala Phe Val Ser Gly Tyr 
        115                 120                 125             

Asn Ala Asn Arg Tyr Ser Phe Ser Arg Asn Val Met Phe Val Leu Gln 
    130                 135                 140                 

Arg Val Thr Gly Ile Ile Thr Phe Val Phe Ile Ile Phe His Leu Trp 
145                 150                 155                 160 

Thr Thr Arg Phe Ser Gly Asn Ala Pro Ser Phe Asp Met Val His Glu 
                165                 170                 175     

Leu Val Thr Asp Asn Ala Tyr Phe Ala Phe Met Ile Val Gly Val Ile 
            180                 185                 190         

Ala Ala Thr Phe His Phe Ser Asn Gly Leu Trp Ser Phe Ala Ile His 
        195                 200                 205             

Trp Gly Ile Thr Val Gly Arg Arg Ala Gln Arg Ile Thr Ala Trp Val 
    210                 215                 220                 

Thr Met Ile Met Phe Val Val Leu Ala Ala Val Gly Val Ala Ser Leu 
225                 230                 235                 240 

Ile Ala Phe Arg Met Asn Val 
                245         

<210>   1097
<211>   247
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1089

<400>   1097
Met Pro Asn Gly Trp Arg Arg Ala Ser Arg Trp Pro Ala Val Phe Cys 
                5                   10                  15      

Thr Cys Thr Ala Ile Pro Pro Arg Ile His Thr Val Phe Ser Phe Gly 
            20                  25                  30          

Gly Leu Lys Gly Gly Thr Gln Val Ala Val Ala Gln Ala Ala Gln His 
        35                  40                  45              

Asn Arg Glu Phe Phe Trp Arg Arg Leu His Thr Leu Ser Gly Val Ile 
    50                  55                  60                  

Pro Val Gly Leu Phe Leu Leu Glu His Leu Phe Thr Asn Ala Thr Ala 
65                  70                  75                  80  

Leu Gly Gly Ala Ala Ala Phe Asn Glu Ala Val Gln Ala Ile Gln Ser 
                85                  90                  95      

Leu Pro Leu Leu His Val Ile Glu Phe Val Phe Ile Phe Leu Pro Ile 
            100                 105                 110         

Thr Tyr His Gly Val Phe Gly Leu Tyr Val Ala Phe Val Ser Gly Tyr 
        115                 120                 125             

Asn Ala Asn Arg Tyr Ser Phe Ser Arg Asn Val Met Phe Val Leu Gln 
    130                 135                 140                 

Arg Val Thr Gly Ile Ile Thr Phe Val Phe Ile Ile Phe His Leu Trp 
145                 150                 155                 160 

Thr Thr Arg Phe Ser Gly Asn Ala Pro Ser Phe Asp Met Val His Glu 
                165                 170                 175     

Leu Val Thr Asp Asn Ala Tyr Phe Ala Phe Met Ile Val Gly Val Ile 
            180                 185                 190         

Ala Ala Thr Phe His Phe Ser Asn Gly Leu Trp Ser Phe Ala Ile His 
        195                 200                 205             

Trp Gly Ile Thr Val Gly Arg Arg Ala Gln Arg Ile Thr Ala Trp Val 
    210                 215                 220                 

Thr Met Ile Met Phe Val Val Leu Ala Ala Val Gly Val Ala Ser Leu 
225                 230                 235                 240 

Ile Ala Phe Arg Met Asn Val 
                245         

<210>   1098
<211>   247
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1089

<400>   1098
Met Pro Asn Gly Trp Arg Arg Ala Ser Arg Trp Pro Ala Val Phe Cys 
                5                   10                  15      

Thr Cys Thr Ala Ile Pro Pro Arg Val His Thr Ile Phe Ser Phe Gly 
            20                  25                  30          

Gly Leu Lys Gly Gly Thr Gln Val Ala Val Ala Gln Ala Ala Gln His 
        35                  40                  45              

Asn Arg Glu Phe Phe Trp Arg Arg Leu His Thr Leu Ser Gly Val Ile 
    50                  55                  60                  

Pro Val Gly Leu Phe Leu Leu Glu His Leu Phe Thr Asn Ala Thr Ala 
65                  70                  75                  80  

Leu Gly Gly Ala Ala Ala Phe Asn Glu Ala Val Gln Ala Ile Gln Ser 
                85                  90                  95      

Leu Pro Leu Leu His Val Ile Glu Phe Val Phe Ile Phe Leu Pro Ile 
            100                 105                 110         

Thr Tyr His Gly Val Phe Gly Leu Tyr Val Ala Phe Val Ser Gly Tyr 
        115                 120                 125             

Asn Ala Asn Arg Tyr Ser Phe Ser Arg Asn Val Met Phe Val Leu Gln 
    130                 135                 140                 

Arg Val Thr Gly Ile Ile Thr Phe Val Phe Ile Ile Phe His Leu Trp 
145                 150                 155                 160 

Thr Thr Arg Phe Ser Gly Asn Ala Pro Ser Phe Asp Met Val His Glu 
                165                 170                 175     

Leu Val Thr Asp Asn Ala Tyr Phe Ala Phe Met Ile Val Gly Val Ile 
            180                 185                 190         

Ala Ala Thr Phe His Phe Ser Asn Gly Leu Trp Ser Phe Ala Ile His 
        195                 200                 205             

Trp Gly Ile Thr Val Gly Arg Arg Ala Gln Arg Ile Thr Ala Trp Val 
    210                 215                 220                 

Thr Met Ile Met Phe Val Val Leu Ala Ala Val Gly Val Ala Ser Leu 
225                 230                 235                 240 

Ile Ala Phe Arg Met Asn Val 
                245         

<210>   1099
<211>   247
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1089

<400>   1099
Met Pro Asn Gly Trp Arg Arg Ala Ser Arg Trp Pro Ala Val Phe Cys 
                5                   10                  15      

Thr Cys Thr Ala Ile Pro Pro Arg Val His Thr Val Phe Ser Phe Gly 
            20                  25                  30          

Gly Leu Lys Gly Gly Thr Gln Val Ala Ile Ala Gln Ala Ala Gln His 
        35                  40                  45              

Asn Arg Glu Phe Phe Trp Arg Arg Leu His Thr Leu Ser Gly Val Ile 
    50                  55                  60                  

Pro Val Gly Leu Phe Leu Leu Glu His Leu Phe Thr Asn Ala Thr Ala 
65                  70                  75                  80  

Leu Gly Gly Ala Ala Ala Phe Asn Glu Ala Val Gln Ala Ile Gln Ser 
                85                  90                  95      

Leu Pro Leu Leu His Val Ile Glu Phe Val Phe Ile Phe Leu Pro Ile 
            100                 105                 110         

Thr Tyr His Gly Val Phe Gly Leu Tyr Val Ala Phe Val Ser Gly Tyr 
        115                 120                 125             

Asn Ala Asn Arg Tyr Ser Phe Ser Arg Asn Val Met Phe Val Leu Gln 
    130                 135                 140                 

Arg Val Thr Gly Ile Ile Thr Phe Val Phe Ile Ile Phe His Leu Trp 
145                 150                 155                 160 

Thr Thr Arg Phe Ser Gly Asn Ala Pro Ser Phe Asp Met Val His Glu 
                165                 170                 175     

Leu Val Thr Asp Asn Ala Tyr Phe Ala Phe Met Ile Val Gly Val Ile 
            180                 185                 190         

Ala Ala Thr Phe His Phe Ser Asn Gly Leu Trp Ser Phe Ala Ile His 
        195                 200                 205             

Trp Gly Ile Thr Val Gly Arg Arg Ala Gln Arg Ile Thr Ala Trp Val 
    210                 215                 220                 

Thr Met Ile Met Phe Val Val Leu Ala Ala Val Gly Val Ala Ser Leu 
225                 230                 235                 240 

Ile Ala Phe Arg Met Asn Val 
                245         

<210>   1100
<211>   247
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1089

<400>   1100
Met Pro Asn Gly Trp Lys Arg Ala Ser Arg Trp Pro Ala Val Phe Cys 
                5                   10                  15      

Thr Cys Thr Ala Ile Pro Pro Arg Val His Thr Val Phe Ser Phe Gly 
            20                  25                  30          

Gly Leu Lys Gly Gly Thr Gln Val Ala Val Ala Gln Ala Ala Gln His 
        35                  40                  45              

Asn Arg Glu Phe Phe Trp Arg Arg Leu His Thr Leu Ser Gly Val Ile 
    50                  55                  60                  

Pro Val Gly Leu Phe Leu Leu Glu His Leu Phe Thr Asn Ala Thr Ala 
65                  70                  75                  80  

Leu Gly Gly Ala Ala Ala Phe Asn Glu Ala Val Gln Ala Ile Gln Ser 
                85                  90                  95      

Leu Pro Leu Leu His Val Ile Glu Phe Val Phe Ile Phe Leu Pro Ile 
            100                 105                 110         

Thr Tyr His Gly Val Phe Gly Leu Tyr Val Ala Phe Val Ser Gly Tyr 
        115                 120                 125             

Asn Ala Asn Arg Tyr Ser Phe Ser Arg Asn Val Met Phe Val Leu Gln 
    130                 135                 140                 

Arg Val Thr Gly Ile Ile Thr Phe Val Phe Ile Ile Phe His Leu Trp 
145                 150                 155                 160 

Thr Thr Arg Phe Ser Gly Asn Ala Pro Ser Phe Asp Met Val His Glu 
                165                 170                 175     

Leu Val Thr Asp Asn Ala Tyr Phe Ala Phe Met Ile Val Gly Val Ile 
            180                 185                 190         

Ala Ala Thr Phe His Phe Ser Asn Gly Leu Trp Ser Phe Ala Ile His 
        195                 200                 205             

Trp Gly Ile Thr Val Gly Arg Arg Ala Gln Arg Ile Thr Ala Trp Val 
    210                 215                 220                 

Thr Met Ile Met Phe Val Val Leu Ala Ala Val Gly Val Ala Ser Leu 
225                 230                 235                 240 

Ile Ala Phe Arg Met Asn Val 
                245         

<210>   1101
<211>   744
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1090

<400>   1101
gtgccaaacg ggtggcggcg tgcgtcgcgc tggcctgcgg tgttttgcac ttgcacggcg       60

ttaccgccgc gcgtacatac tgttttctct tttgggggat tgaagggagg aacccaagtg      120

gcagtggccc aagcagccca gcacaaccgg gagtttttct ggcggcggct ccacacgctc      180

tcgggcgtca ttccggtggg actgttcctg ctggagcacc tgttcacgaa cgcgacggcc      240

ctgggcggtg cggcggcttt caacgaagcc gtgcaagcga ttcaatcgct tccgctcctg      300

cacgtcattg agttcgtgtt catcttcctg cccatcacgt atcacggcgt gtttgggctt      360

tacgtggcgt tcgtgtccgg ctacaacgcg aatcggtatt cgttcagccg caacgtgatg      420

ttcgtgttgc agcgggtgac gggcatcatc accttcgtct tcatcatttt ccacctgtgg      480

acgacgcggt tttccggcaa cgcgccgtcg tttgacatgg tgcacgagct cgtcaccgac      540

aatgcgtact tcgcgttcat gatcgtgggc gtgatcgcgg cgacgttcca cttctcgaac      600

ggactgtggt cgttcgccat tcattggggc atcacggttg ggcgccgggc gcagcgcatc      660

accgcgtggg tgacgatgat catgtttgtc gtgctggcgg cggtcggtgt ggcgtcgctg      720

attgcgttcc gcatgaacgt ctga                                             744


<210>   1102
<211>   744
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1090

<400>   1102
gtgccaaacg ggtggcggcg tgcgtcgcgc tggcctgcgg tgttttgcac ttgcacggcg       60

atcccgccgc gcattcatac tgttttctct tttgggggat tgaagggagg aacccaagtg      120

gcagtggccc aagcagccca gcacaaccgg gagtttttct ggcggcggct ccacacgctc      180

tcgggcgtca ttccggtggg actgttcctg ctggagcacc tgttcacgaa cgcgacggcc      240

ctgggcggtg cggcggcttt caacgaagcc gtgcaagcga ttcaatcgct tccgctcctg      300

cacgtcattg agttcgtgtt catcttcctg cccatcacgt atcacggcgt gtttgggctt      360

tacgtggcgt tcgtgtccgg ctacaacgcg aatcggtatt cgttcagccg caacgtgatg      420

ttcgtgttgc agcgggtgac gggcatcatc accttcgtct tcatcatttt ccacctgtgg      480

acgacgcggt tttccggcaa cgcgccgtcg tttgacatgg tgcacgagct cgtcaccgac      540

aatgcgtact tcgcgttcat gatcgtgggc gtgatcgcgg cgacgttcca cttctcgaac      600

ggactgtggt cgttcgccat tcattggggc atcacggttg ggcgccgggc gcagcgcatc      660

accgcgtggg tgacgatgat catgtttgtc gtgctggcgg cggtcggtgt ggcgtcgctg      720

attgcgttcc gcatgaacgt ctga                                             744


<210>   1103
<211>   744
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1090

<400>   1103
gtgccaaacg ggtggcggcg tgcgtcgcgc tggcctgcgg tgttttgcac ttgcacggcg       60

atcccgccgc gcgtacatac tattttctct tttgggggat tgaagggagg aacccaagtg      120

gcagtggccc aagcagccca gcacaaccgg gagtttttct ggcggcggct ccacacgctc      180

tcgggcgtca ttccggtggg actgttcctg ctggagcacc tgttcacgaa cgcgacggcc      240

ctgggcggtg cggcggcttt caacgaagcc gtgcaagcga ttcaatcgct tccgctcctg      300

cacgtcattg agttcgtgtt catcttcctg cccatcacgt atcacggcgt gtttgggctt      360

tacgtggcgt tcgtgtccgg ctacaacgcg aatcggtatt cgttcagccg caacgtgatg      420

ttcgtgttgc agcgggtgac gggcatcatc accttcgtct tcatcatttt ccacctgtgg      480

acgacgcggt tttccggcaa cgcgccgtcg tttgacatgg tgcacgagct cgtcaccgac      540

aatgcgtact tcgcgttcat gatcgtgggc gtgatcgcgg cgacgttcca cttctcgaac      600

ggactgtggt cgttcgccat tcattggggc atcacggttg ggcgccgggc gcagcgcatc      660

accgcgtggg tgacgatgat catgtttgtc gtgctggcgg cggtcggtgt ggcgtcgctg      720

attgcgttcc gcatgaacgt ctga                                             744


<210>   1104
<211>   744
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1090

<400>   1104
gtgccaaacg ggtggcggcg tgcgtcgcgc tggcctgcgg tgttttgcac ttgcacggcg       60

atcccgccgc gcgtacatac tgttttctct tttgggggat tgaagggagg aacccaagtg      120

gcaattgccc aagcagccca gcacaaccgg gagtttttct ggcggcggct ccacacgctc      180

tcgggcgtca ttccggtggg actgttcctg ctggagcacc tgttcacgaa cgcgacggcc      240

ctgggcggtg cggcggcttt caacgaagcc gtgcaagcga ttcaatcgct tccgctcctg      300

cacgtcattg agttcgtgtt catcttcctg cccatcacgt atcacggcgt gtttgggctt      360

tacgtggcgt tcgtgtccgg ctacaacgcg aatcggtatt cgttcagccg caacgtgatg      420

ttcgtgttgc agcgggtgac gggcatcatc accttcgtct tcatcatttt ccacctgtgg      480

acgacgcggt tttccggcaa cgcgccgtcg tttgacatgg tgcacgagct cgtcaccgac      540

aatgcgtact tcgcgttcat gatcgtgggc gtgatcgcgg cgacgttcca cttctcgaac      600

ggactgtggt cgttcgccat tcattggggc atcacggttg ggcgccgggc gcagcgcatc      660

accgcgtggg tgacgatgat catgtttgtc gtgctggcgg cggtcggtgt ggcgtcgctg      720

attgcgttcc gcatgaacgt ctga                                             744


<210>   1105
<211>   744
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1090

<400>   1105
gtgccaaacg ggtggaaacg tgcgtcgcgc tggcctgcgg tgttttgcac ttgcacggcg       60

atcccgccgc gcgtacatac tgttttctct tttgggggat tgaagggagg aacccaagtg      120

gcagtggccc aagcagccca gcacaaccgg gagtttttct ggcggcggct ccacacgctc      180

tcgggcgtca ttccggtggg actgttcctg ctggagcacc tgttcacgaa cgcgacggcc      240

ctgggcggtg cggcggcttt caacgaagcc gtgcaagcga ttcaatcgct tccgctcctg      300

cacgtcattg agttcgtgtt catcttcctg cccatcacgt atcacggcgt gtttgggctt      360

tacgtggcgt tcgtgtccgg ctacaacgcg aatcggtatt cgttcagccg caacgtgatg      420

ttcgtgttgc agcgggtgac gggcatcatc accttcgtct tcatcatttt ccacctgtgg      480

acgacgcggt tttccggcaa cgcgccgtcg tttgacatgg tgcacgagct cgtcaccgac      540

aatgcgtact tcgcgttcat gatcgtgggc gtgatcgcgg cgacgttcca cttctcgaac      600

ggactgtggt cgttcgccat tcattggggc atcacggttg ggcgccgggc gcagcgcatc      660

accgcgtggg tgacgatgat catgtttgtc gtgctggcgg cggtcggtgt ggcgtcgctg      720

attgcgttcc gcatgaacgt ctga                                             744


<210>   1106
<211>   287
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1106
Met Ala Gln Asn Ser Met Arg Asp Ile Arg Arg Arg Ile Lys Ser Val 
                5                   10                  15      

Arg Asn Thr Ala Gln Ile Thr Lys Ala Met Glu Met Val Ala Ala Ala 
            20                  25                  30          

Lys Leu Arg Arg Val Gln Asp Ala Val Gln Gln Ser Lys Pro Tyr Leu 
        35                  40                  45              

Ser Lys Met Gln Glu Met Leu Ala Asn Leu Ser Leu Ser Ala Arg Leu 
    50                  55                  60                  

Val Lys His Pro Leu Leu Ala Val Arg Pro Val Arg Arg Ile Gly Tyr 
65                  70                  75                  80  

Leu Val Ile Thr Ala Asp Arg Gly Leu Ala Gly Pro Tyr Asn Ala Gln 
                85                  90                  95      

Val Val Arg Ala Ala Met Gln Glu Phe Gly Lys Arg Asp Lys Gly Ser 
            100                 105                 110         

Tyr Ala Ile Tyr Thr Val Gly Lys Arg Gly Arg Asn Phe Phe Gln Arg 
        115                 120                 125             

Arg Gly Leu Pro Ile Ala Ala Glu Val Val Asp Leu Pro Asp Thr Pro 
    130                 135                 140                 

Thr Tyr His Ser Val Arg His Leu Ala Glu Asn Ile Val Ala Ala Tyr 
145                 150                 155                 160 

Glu Arg Glu Glu Phe Asp Glu Leu Tyr Phe Ile Tyr Asn Glu Phe Ile 
                165                 170                 175     

Asn Ala Ala Val Gln Arg Pro Val Val Arg Lys Val Leu Pro Leu Ala 
            180                 185                 190         

Ser Leu Gly Glu Asn Val Gln Gly Pro Arg Arg Asn Tyr Leu Phe Glu 
        195                 200                 205             

Pro Asp Glu Glu Ser Val Leu Ala Ala Leu Leu Pro Arg Tyr Ala Glu 
    210                 215                 220                 

Thr Leu Val Tyr Gln Ala Val Leu Asp Ala Lys Ala Ser Glu His Ala 
225                 230                 235                 240 

Ala Arg Met Asn Ala Met Gly Asn Ala Thr Asp Asn Ala Leu Glu Leu 
                245                 250                 255     

Ile Glu Lys Leu Thr Leu Ser Leu Asn Arg Ala Arg Gln Ala Ala Ile 
            260                 265                 270         

Thr Thr Gln Ile Ala Glu Ile Val Gly Gly Ala Glu Ala Leu Lys 
        275                 280                 285         

<210>   1107
<211>   864
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1107
atggcgcaaa acagcatgcg cgacatccgg cggcgcatca agagcgtccg gaatactgcg       60

cagatcacga aggcgatgga gatggtcgcg gccgccaagc tgcgccgcgt gcaggatgcg      120

gttcagcagt cgaagccgta cctctcgaag atgcaggaga tgctggcgaa cctgtcgctc      180

tcggcgcggc tcgtcaagca tccgctgctc gcggtgcgac ccgtgcggcg catcggctac      240

ctcgtcatca cggccgatcg cggcctggcc gggccgtaca acgcgcaggt ggtgcgcgcc      300

gcgatgcagg agtttggcaa gcgagacaag ggctcgtacg ccatttacac ggtcggcaag      360

cgagggcgga actttttcca gcgccgtggg ctgccgatcg cggccgaggt cgtcgatctc      420

cccgacacgc ccacgtatca ctccgtgcgc catctggcgg agaacatcgt cgcggcgtac      480

gagcgcgagg agttcgacga gctgtatttc atctacaacg agttcatcaa cgcggcggtt      540

caacgcccgg tggtgcgcaa agtgctgcct cttgcctccc ttggcgagaa cgtgcagggg      600

ccacggcgca actatctgtt cgagcccgac gaggagtcgg tgctggcggc tctccttccg      660

cggtatgccg agacgctggt gtatcaggcg gtgttggacg cgaaggcttc cgaacatgct      720

gcgcgcatga atgcgatggg caacgcgacc gacaacgcgc ttgagctgat cgagaaactg      780

acgctgtcgt tgaaccgggc gcgccaggcg gcgatcacga cccagatcgc ggaaattgtc      840

ggtggcgcgg aagcgttgaa ataa                                             864


<210>   1108
<211>   283
<212>   PRT
<213>   Bacillus sp. TA2.A1

<400>   1108
Met Arg Glu Ile Lys Arg Arg Ile Arg Ser Val Lys Asn Thr Arg Gln 
                5                   10                  15      

Ile Thr Lys Ala Met Lys Met Val Ala Ala Ala Lys Leu Arg Arg Ala 
            20                  25                  30          

Gln Glu Thr Ala Glu Asn Ala Arg Pro Tyr Ala Asp Lys Ile Lys Glu 
        35                  40                  45              

Val Ile Ser Ser Ile Ala Ala Gly Thr Lys Asp Phe Ser His Pro Met 
    50                  55                  60                  

Leu Glu Ala Arg Pro Val Lys Lys Thr Gly Tyr Met Val Ile Thr Ser 
65                  70                  75                  80  

Asp Arg Gly Leu Ala Gly Pro Tyr Asn Ala Asn Ile Leu Arg Leu Val 
                85                  90                  95      

Ser Lys Thr Ile Glu Glu Arg His Gln Ser Lys Asp Glu Tyr Val Ile 
            100                 105                 110         

Phe Ala Val Gly Arg Lys Gly Arg Asp Phe Phe Lys Lys Arg Gly Tyr 
        115                 120                 125             

Pro Val Val Glu Glu Val Thr Gly Ile Ser Asp Thr Pro Ser Leu Thr 
    130                 135                 140                 

Glu Ile Gln Asp Ile Ala Gln Ser Ala Ile Gly Met Phe Ala Asp Glu 
145                 150                 155                 160 

Thr Phe Asp Lys Leu Thr Ile Phe Tyr Asn Glu Phe Val Ser Pro Ile 
                165                 170                 175     

Val Gln Arg Pro Val Glu Lys Gln Leu Leu Pro Leu Thr Ser Glu Glu 
            180                 185                 190         

Val Leu Asp Gly Pro Val Ser Ala Tyr Glu Tyr Glu Pro Asp Ser Glu 
        195                 200                 205             

Ser Val Leu Glu Val Leu Leu Pro Lys Tyr Ala Glu Thr Leu Ile Tyr 
    210                 215                 220                 

Ser Ala Leu Leu Asp Ala Lys Ala Ser Glu Phe Gly Ala Arg Met Thr 
225                 230                 235                 240 

Ala Met Gly Asn Ala Thr Asp Asn Ala Thr Glu Met Leu Glu Thr Leu 
                245                 250                 255     

Thr Leu Gln Phe Asn Arg Ala Arg Gln Ala Ala Ile Thr Gln Glu Ile 
            260                 265                 270         

Ala Glu Ile Val Ala Gly Ala Asn Ala Leu Arg 
        275                 280             

<210>   1109
<211>   283
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1109
Ser Leu Arg Asp Ile Lys Thr Arg Ile Asn Ser Thr Lys Lys Thr Ser 
                5                   10                  15      

Gln Ile Thr Lys Ala Met Glu Met Val Ser Thr Ser Lys Leu Asn Arg 
            20                  25                  30          

Ala Glu Gln Asn Ala Lys Ser Phe Val Pro Tyr Met Glu Lys Met Gln 
        35                  40                  45              

Glu Val Val Ala Asn Val Ala Leu Gly Ala Gly Gly Ala Ser His Pro 
    50                  55                  60                  

Met Leu Ile Ser Arg Pro Val Lys Lys Thr Gly Tyr Leu Val Ile Thr 
65                  70                  75                  80  

Ser Asp Arg Gly Leu Ala Gly Ala Tyr Asn Ser Asn Val Leu Arg Thr 
                85                  90                  95      

Val Tyr Gln Thr Ile Gln Ala Arg His Ser Ser Pro Asp Glu Tyr Ala 
            100                 105                 110         

Ile Ile Val Ile Gly Arg Val Gly Leu Asn Phe Phe Arg Lys Arg Asn 
        115                 120                 125             

Met Pro Val Ile Leu Asp Ile Thr Arg Leu Pro Asp Gln Pro Ser Phe 
    130                 135                 140                 

Ala Asp Ile Lys Glu Ile Ala Asn Lys Ala Val Gly Leu Phe Ala Asp 
145                 150                 155                 160 

Gly Thr Phe Asp Glu Leu Tyr Met Tyr Tyr Asn His Tyr Val Ser Ala 
                165                 170                 175     

Ile Gln Gln Asp Val Thr Glu Arg Lys Leu Leu Pro Leu Thr Asp Leu 
            180                 185                 190         

Ala Asp Asn Gln Gln Arg Thr Met Tyr Glu Phe Glu Pro Ser Gln Glu 
        195                 200                 205             

Glu Ile Leu Asp Val Leu Leu Pro Gln Tyr Ala Glu Ser Leu Ile Tyr 
    210                 215                 220                 

Gly Ala Leu Leu Asp Ala Lys Ala Ser Glu His Ala Ala Arg Met Thr 
225                 230                 235                 240 

Ala Met Lys Asn Ala Thr Asp Asn Ala His Glu Leu Ile Arg Thr Leu 
                245                 250                 255     

Thr Leu Ser Tyr Asn Arg Ala Arg Gln Ala Ser Ile Thr Gln Glu Ile 
            260                 265                 270         

Thr Glu Ile Val Ala Gly Ala Asn Ala Leu Gln 
        275                 280             

<210>   1110
<211>   283
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1110
Ser Leu Arg Asp Ile Lys Thr Arg Ile Asn Ala Thr Lys Lys Thr Ser 
                5                   10                  15      

Gln Ile Thr Lys Ala Met Glu Met Val Ser Thr Ser Lys Leu Asn Arg 
            20                  25                  30          

Ala Glu Gln Asn Ala Lys Ser Phe Val Pro Tyr Met Glu Lys Ile Gln 
        35                  40                  45              

Glu Val Val Ala Asn Val Ala Leu Gly Ala Gly Gly Ala Ser His Pro 
    50                  55                  60                  

Met Leu Val Ser Arg Pro Val Lys Lys Thr Gly Tyr Leu Val Ile Thr 
65                  70                  75                  80  

Ser Asp Arg Gly Leu Ala Gly Ala Tyr Asn Ser Asn Val Leu Arg Leu 
                85                  90                  95      

Val Tyr Gln Thr Ile Gln Lys Arg His Ala Ser Pro Asp Glu Tyr Ala 
            100                 105                 110         

Ile Ile Val Ile Gly Arg Val Gly Leu Ser Phe Phe Arg Lys Arg Asn 
        115                 120                 125             

Met Pro Val Ile Leu Asp Ile Thr Arg Leu Pro Asp Gln Pro Ser Phe 
    130                 135                 140                 

Ala Asp Ile Lys Glu Ile Ala Arg Lys Thr Val Gly Leu Phe Ala Asp 
145                 150                 155                 160 

Gly Thr Phe Asp Glu Leu Tyr Met Tyr Tyr Asn His Tyr Val Ser Ala 
                165                 170                 175     

Ile Gln Gln Glu Val Thr Glu Arg Lys Leu Leu Pro Leu Thr Asp Leu 
            180                 185                 190         

Ala Glu Asn Lys Gln Arg Thr Val Tyr Glu Phe Glu Pro Ser Gln Glu 
        195                 200                 205             

Glu Ile Leu Asp Val Leu Leu Pro Gln Tyr Ala Glu Ser Leu Ile Tyr 
    210                 215                 220                 

Gly Ala Leu Leu Asp Ala Lys Ala Ser Glu His Ala Ala Arg Met Thr 
225                 230                 235                 240 

Ala Met Lys Asn Ala Thr Asp Asn Ala Asn Glu Leu Ile Arg Thr Leu 
                245                 250                 255     

Thr Leu Ser Tyr Asn Arg Ala Arg Gln Ala Ala Ile Thr Gln Glu Ile 
            260                 265                 270         

Thr Glu Ile Val Ala Gly Ala Asn Ala Leu Gln 
        275                 280             

<210>   1111
<211>   286
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   1111
Ser Leu Arg Asp Ile Lys Ser Arg Ile Thr Ser Thr Lys Lys Ser Ser 
                5                   10                  15      

Gln Ile Thr Lys Ala Met Gln Met Val Ser Ala Ala Lys Leu Asn Arg 
            20                  25                  30          

Ala Glu Asn Asn Ala Lys Ser Phe Val Pro Tyr Met Glu Lys Ile Gln 
        35                  40                  45              

Glu Val Val Ala Ala Ile Ala Thr Gly Thr Ser Ala Lys His Pro Met 
    50                  55                  60                  

Leu Leu Ser Arg Pro Val Lys Lys Thr Gly Tyr Leu Val Ile Thr Ser 
65                  70                  75                  80  

Asp Arg Gly Leu Ala Gly Pro Phe Asn Ser Ser Ile Leu Arg Ala Ala 
                85                  90                  95      

Tyr Gln Thr Ile Gln Ser Arg His Gln Ser Ala Asp Glu Tyr Ala Val 
            100                 105                 110         

Ile Val Ile Gly Lys Ile Gly Arg Asp Phe Phe Lys Lys Arg Gly Ile 
        115                 120                 125             

Pro Val Ile Ser Glu Val Thr Gly Leu Gly Asp Glu Val Ala Phe Ala 
    130                 135                 140                 

Asp Ile Lys Glu Leu Ala Ser Ser Thr Val Gln Met Phe Ser Asp Glu 
145                 150                 155                 160 

Ala Phe Asp Glu Leu Tyr Met Phe Tyr Asn His Phe Val Ser Ala Ile 
                165                 170                 175     

Ser Gln Glu Val Thr Glu Lys Lys Leu Leu Pro Leu Thr Asp Ile Ser 
            180                 185                 190         

Ala Ala Ala Thr Pro Asn Lys Arg Ser Ala Ser Tyr Glu Phe Glu Pro 
        195                 200                 205             

Ser Glu Glu Glu Ile Leu Glu Val Leu Leu Pro Gln Tyr Ala Glu Ser 
    210                 215                 220                 

Leu Ile Phe Gly Ala Leu Leu Asp Ser Lys Ala Ser Glu His Ala Ala 
225                 230                 235                 240 

Arg Met Thr Ala Met Lys Ser Ala Thr Asp Asn Ala Lys Glu Leu Ile 
                245                 250                 255     

Asp Ser Leu Thr Leu Ser Tyr Asn Arg Ala Arg Gln Ala Ala Ile Thr 
            260                 265                 270         

Gln Glu Ile Thr Glu Ile Val Gly Gly Ala Ala Ala Leu Glu 
        275                 280                 285     

<210>   1112
<211>   281
<212>   PRT
<213>   Bacillus sp. PS3

<400>   1112
Ser Leu Arg Asp Ile Lys Thr Arg Ile Asn Ala Thr Lys Lys Thr Ser 
                5                   10                  15      

Gln Ile Thr Lys Ala Met Glu Met Val Leu Thr Ser Lys Leu Asn Arg 
            20                  25                  30          

Ala Glu Lys Arg Glu Ile Val Arg Pro Tyr Met Glu Lys Ile Gln Glu 
        35                  40                  45              

Val Val Ala Asn Val Ala Leu Ala Ala Arg Ala Ser His Pro Met Leu 
    50                  55                  60                  

Val Ser Arg Pro Val Lys Lys Thr Gly Tyr Leu Val Ile Thr Ser Asp 
65                  70                  75                  80  

Arg Gly Leu Ala Gly Ala Tyr Asn Ser Asn Val Leu Arg Leu Val Tyr 
                85                  90                  95      

Gln Thr Ile Gln Lys Arg His Ala Ser Pro Asp Glu Tyr Ala Ile Ile 
            100                 105                 110         

Val Ile Gly Arg Val Gly Leu Ser Phe Phe Arg Lys Arg Asn Met Pro 
        115                 120                 125             

Val Ile Leu Asp Ile Thr Arg Leu Pro Asp Gln Pro Ser Phe Ala Asp 
    130                 135                 140                 

Ile Lys Glu Ile Ala Arg Lys Thr Val Gly Leu Phe Ala Asp Gly Thr 
145                 150                 155                 160 

Phe Asp Glu Leu Tyr Met Tyr Tyr Asn His Tyr Val Ser Ala Ile Gln 
                165                 170                 175     

Gln Glu Val Thr Glu Arg Lys Leu Leu Pro Leu Thr Asp Leu Ala Glu 
            180                 185                 190         

Asn Lys Gln Arg Thr Val Tyr Glu Phe Glu Pro Ser Gln Glu Glu Ile 
        195                 200                 205             

Leu Asp Val Leu Leu Pro Gln Tyr Ala Glu Ser Leu Ile Tyr Gly Ala 
    210                 215                 220                 

Leu Leu Asp Ala Lys Ala Ser Glu His Ala Ala Arg Met Thr Ala Met 
225                 230                 235                 240 

Lys Asn Ala Thr Asp Asn Ala Asn Glu Leu Ile Arg Thr Leu Thr Leu 
                245                 250                 255     

Ser Tyr Asn Arg Ala Arg Gln Ala Ala Ile Thr Gln Glu Ile Thr Glu 
            260                 265                 270         

Ile Val Ala Gly Ala Asn Ala Leu Gln 
        275                 280     

<210>   1113
<211>   287
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1106

<400>   1113
Met Ala Gln Asn Ser Met Arg Asp Ile Arg Arg Arg Ile Lys Ser Val 
                5                   10                  15      

Arg Asn Thr Ala Gln Ile Thr Lys Ala Met Glu Met Val Ala Ala Ala 
            20                  25                  30          

Lys Leu Arg Arg Val Gln Asp Ala Val Gln Gln Ser Lys Pro Tyr Leu 
        35                  40                  45              

Ser Lys Met Gln Glu Met Leu Ala Asn Leu Ser Leu Ser Ala Arg Leu 
    50                  55                  60                  

Val Lys His Pro Leu Leu Ala Val Arg Pro Val Arg Arg Ile Gly Tyr 
65                  70                  75                  80  

Leu Val Ile Thr Ala Asp Arg Gly Leu Ala Gly Pro Tyr Asn Ala Gln 
                85                  90                  95      

Val Val Arg Ala Ala Met Gln Asp Phe Gly Lys Arg Asp Lys Gly Ser 
            100                 105                 110         

Tyr Ala Ile Tyr Thr Val Gly Lys Arg Gly Arg Asn Phe Phe Gln Arg 
        115                 120                 125             

Arg Gly Leu Pro Ile Ala Ala Glu Val Val Asp Leu Pro Asp Thr Pro 
    130                 135                 140                 

Thr Tyr His Ser Val Arg His Leu Ala Glu Asn Ile Val Ala Ala Tyr 
145                 150                 155                 160 

Glu Arg Glu Glu Phe Asp Glu Leu Tyr Phe Ile Tyr Asn Glu Phe Ile 
                165                 170                 175     

Asn Ala Ala Val Gln Arg Pro Val Val Arg Lys Val Leu Pro Leu Ala 
            180                 185                 190         

Ser Leu Gly Glu Asn Val Gln Gly Pro Arg Arg Asn Tyr Leu Phe Glu 
        195                 200                 205             

Pro Asp Glu Glu Ser Val Leu Ala Ala Leu Leu Pro Arg Tyr Ala Glu 
    210                 215                 220                 

Thr Leu Val Tyr Gln Ala Val Leu Asp Ala Lys Ala Ser Glu His Ala 
225                 230                 235                 240 

Ala Arg Met Asn Ala Met Gly Asn Ala Thr Asp Asn Ala Leu Glu Leu 
                245                 250                 255     

Ile Glu Lys Leu Thr Leu Ser Leu Asn Arg Ala Arg Gln Ala Ala Ile 
            260                 265                 270         

Thr Thr Gln Ile Ala Glu Ile Val Gly Gly Ala Glu Ala Leu Lys 
        275                 280                 285         

<210>   1114
<211>   287
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1106

<400>   1114
Met Ala Gln Asn Ser Met Arg Asp Ile Arg Arg Arg Ile Lys Ser Val 
                5                   10                  15      

Arg Asn Thr Ala Gln Ile Thr Lys Ala Met Glu Met Val Ala Ala Ala 
            20                  25                  30          

Lys Leu Arg Arg Val Gln Asp Ala Val Gln Gln Ser Lys Pro Tyr Leu 
        35                  40                  45              

Ser Lys Met Gln Glu Met Leu Ala Asn Leu Ser Leu Ser Ala Arg Leu 
    50                  55                  60                  

Val Lys His Pro Leu Leu Ala Val Arg Pro Val Arg Arg Leu Gly Tyr 
65                  70                  75                  80  

Leu Val Ile Thr Ala Asp Arg Gly Leu Ala Gly Pro Tyr Asn Ala Gln 
                85                  90                  95      

Val Val Arg Ala Ala Met Gln Glu Phe Gly Lys Arg Asp Lys Gly Ser 
            100                 105                 110         

Tyr Ala Ile Tyr Thr Val Gly Lys Arg Gly Arg Asn Phe Phe Gln Arg 
        115                 120                 125             

Arg Gly Leu Pro Ile Ala Ala Glu Val Val Asp Leu Pro Asp Thr Pro 
    130                 135                 140                 

Thr Tyr His Ser Val Arg His Leu Ala Glu Asn Ile Val Ala Ala Tyr 
145                 150                 155                 160 

Glu Arg Glu Glu Phe Asp Glu Leu Tyr Phe Ile Tyr Asn Glu Phe Ile 
                165                 170                 175     

Asn Ala Ala Val Gln Arg Pro Val Val Arg Lys Val Leu Pro Leu Ala 
            180                 185                 190         

Ser Leu Gly Glu Asn Val Gln Gly Pro Arg Arg Asn Tyr Leu Phe Glu 
        195                 200                 205             

Pro Asp Glu Glu Ser Val Leu Ala Ala Leu Leu Pro Arg Tyr Ala Glu 
    210                 215                 220                 

Thr Leu Val Tyr Gln Ala Val Leu Asp Ala Lys Ala Ser Glu His Ala 
225                 230                 235                 240 

Ala Arg Met Asn Ala Met Gly Asn Ala Thr Asp Asn Ala Leu Glu Leu 
                245                 250                 255     

Ile Glu Lys Leu Thr Leu Ser Leu Asn Arg Ala Arg Gln Ala Ala Ile 
            260                 265                 270         

Thr Thr Gln Ile Ala Glu Ile Val Gly Gly Ala Glu Ala Leu Lys 
        275                 280                 285         

<210>   1115
<211>   287
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1106

<400>   1115
Met Ala Gln Asn Ser Met Arg Asp Ile Arg Arg Arg Ile Lys Ser Val 
                5                   10                  15      

Arg Asn Thr Ala Gln Ile Thr Lys Ala Met Glu Met Val Ala Ala Ala 
            20                  25                  30          

Lys Leu Arg Arg Val Gln Asp Ala Val Gln Asn Ser Lys Pro Tyr Leu 
        35                  40                  45              

Ser Lys Met Gln Glu Met Leu Ala Asn Leu Ser Leu Ser Ala Arg Leu 
    50                  55                  60                  

Val Lys His Pro Leu Leu Ala Val Arg Pro Val Arg Arg Ile Gly Tyr 
65                  70                  75                  80  

Leu Val Ile Thr Ala Asp Arg Gly Leu Ala Gly Pro Tyr Asn Ala Gln 
                85                  90                  95      

Val Val Arg Ala Ala Met Gln Glu Phe Gly Lys Arg Asp Lys Gly Ser 
            100                 105                 110         

Tyr Ala Ile Tyr Thr Val Gly Lys Arg Gly Arg Asn Phe Phe Gln Arg 
        115                 120                 125             

Arg Gly Leu Pro Ile Ala Ala Glu Val Val Asp Leu Pro Asp Thr Pro 
    130                 135                 140                 

Thr Tyr His Ser Val Arg His Leu Ala Glu Asn Ile Val Ala Ala Tyr 
145                 150                 155                 160 

Glu Arg Glu Glu Phe Asp Glu Leu Tyr Phe Ile Tyr Asn Glu Phe Ile 
                165                 170                 175     

Asn Ala Ala Val Gln Arg Pro Val Val Arg Lys Val Leu Pro Leu Ala 
            180                 185                 190         

Ser Leu Gly Glu Asn Val Gln Gly Pro Arg Arg Asn Tyr Leu Phe Glu 
        195                 200                 205             

Pro Asp Glu Glu Ser Val Leu Ala Ala Leu Leu Pro Arg Tyr Ala Glu 
    210                 215                 220                 

Thr Leu Val Tyr Gln Ala Val Leu Asp Ala Lys Ala Ser Glu His Ala 
225                 230                 235                 240 

Ala Arg Met Asn Ala Met Gly Asn Ala Thr Asp Asn Ala Leu Glu Leu 
                245                 250                 255     

Ile Glu Lys Leu Thr Leu Ser Leu Asn Arg Ala Arg Gln Ala Ala Ile 
            260                 265                 270         

Thr Thr Gln Ile Ala Glu Ile Val Gly Gly Ala Glu Ala Leu Lys 
        275                 280                 285         

<210>   1116
<211>   287
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1106

<400>   1116
Met Ala Gln Asn Ser Met Arg Asp Ile Arg Arg Arg Ile Lys Ser Val 
                5                   10                  15      

Arg Asn Thr Ala Gln Ile Thr Lys Ala Met Glu Met Val Ala Ala Ala 
            20                  25                  30          

Lys Leu Arg Arg Val Gln Asp Ala Val Gln Gln Ser Lys Pro Tyr Leu 
        35                  40                  45              

Ser Lys Met Gln Glu Met Leu Ala Asn Leu Ser Leu Ser Ala Arg Leu 
    50                  55                  60                  

Val Lys His Pro Leu Leu Ala Val Arg Pro Val Arg Arg Ile Gly Tyr 
65                  70                  75                  80  

Leu Val Ile Thr Ala Asp Arg Gly Leu Ala Gly Pro Tyr Asn Ala Gln 
                85                  90                  95      

Val Val Arg Ala Ala Met Gln Glu Phe Gly Lys Arg Asp Lys Gly Ser 
            100                 105                 110         

Tyr Ala Ile Tyr Thr Val Gly Lys Arg Gly Arg Asn Phe Phe Gln Arg 
        115                 120                 125             

Arg Gly Leu Pro Ile Ala Ala Glu Val Val Asp Leu Pro Asp Thr Pro 
    130                 135                 140                 

Thr Tyr His Ser Val Arg His Leu Ala Glu Asn Ile Val Ala Ala Tyr 
145                 150                 155                 160 

Glu Arg Glu Glu Phe Asp Glu Leu Tyr Phe Ile Tyr Asn Glu Phe Ile 
                165                 170                 175     

Asn Ala Ala Val Gln Arg Pro Val Ile Arg Lys Val Leu Pro Leu Ala 
            180                 185                 190         

Ser Leu Gly Glu Asn Val Gln Gly Pro Arg Arg Asn Tyr Leu Phe Glu 
        195                 200                 205             

Pro Asp Glu Glu Ser Val Leu Ala Ala Leu Leu Pro Arg Tyr Ala Glu 
    210                 215                 220                 

Thr Leu Val Tyr Gln Ala Val Leu Asp Ala Lys Ala Ser Glu His Ala 
225                 230                 235                 240 

Ala Arg Met Asn Ala Met Gly Asn Ala Thr Asp Asn Ala Leu Glu Leu 
                245                 250                 255     

Ile Glu Lys Leu Thr Leu Ser Leu Asn Arg Ala Arg Gln Ala Ala Ile 
            260                 265                 270         

Thr Thr Gln Ile Ala Glu Ile Val Gly Gly Ala Glu Ala Leu Lys 
        275                 280                 285         

<210>   1117
<211>   287
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1106

<400>   1117
Met Ala Gln Asn Ser Met Arg Asp Ile Arg Arg Arg Ile Lys Ser Val 
                5                   10                  15      

Arg Asn Thr Ala Gln Ile Thr Lys Ala Met Glu Met Val Ala Ala Ala 
            20                  25                  30          

Lys Leu Arg Arg Val Gln Asp Ala Val Gln Gln Ser Lys Pro Tyr Leu 
        35                  40                  45              

Ser Lys Met Gln Glu Met Leu Ala Asn Leu Ser Leu Ser Ala Arg Leu 
    50                  55                  60                  

Val Lys His Pro Leu Leu Ala Val Arg Pro Val Arg Arg Ile Gly Tyr 
65                  70                  75                  80  

Leu Val Ile Thr Ala Asp Arg Gly Leu Ala Gly Pro Tyr Asn Ala Gln 
                85                  90                  95      

Val Val Arg Ala Ala Met Gln Glu Phe Gly Lys Arg Asp Lys Gly Ser 
            100                 105                 110         

Tyr Ala Ile Tyr Thr Val Gly Lys Arg Gly Arg Asn Phe Phe Gln Arg 
        115                 120                 125             

Arg Gly Leu Pro Ile Ala Ala Glu Val Val Asp Leu Pro Asp Thr Pro 
    130                 135                 140                 

Thr Tyr His Ser Val Arg His Leu Ala Glu Asn Ile Val Ala Ala Tyr 
145                 150                 155                 160 

Glu Arg Glu Glu Phe Asp Glu Leu Tyr Phe Ile Tyr Asn Glu Phe Ile 
                165                 170                 175     

Asn Ala Ala Val Gln Arg Pro Val Val Arg Lys Val Leu Pro Leu Ala 
            180                 185                 190         

Ser Leu Gly Glu Asn Val Gln Gly Pro Arg Arg Asn Tyr Leu Phe Glu 
        195                 200                 205             

Pro Asp Glu Glu Ser Val Leu Ala Ala Leu Leu Pro Arg Tyr Ala Glu 
    210                 215                 220                 

Thr Leu Val Tyr Gln Ala Val Leu Asp Ala Lys Ala Ser Glu His Ala 
225                 230                 235                 240 

Ala Arg Met Asn Ala Met Gly Asn Ala Thr Asp Asn Ala Leu Glu Leu 
                245                 250                 255     

Ile Glu Lys Leu Thr Leu Ser Leu Asn Arg Ala Arg Gln Ala Ala Ile 
            260                 265                 270         

Thr Thr Gln Ile Ala Glu Ile Val Gly Gly Ala Asp Ala Leu Lys 
        275                 280                 285         

<210>   1118
<211>   864
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1107

<400>   1118
atggcgcaaa acagcatgcg cgacatccgg cggcgcatca agagcgtccg gaatactgcg       60

cagatcacga aggcgatgga gatggtcgcg gccgccaagc tgcgccgcgt gcaggatgcg      120

gttcagcagt cgaagccgta cctctcgaag atgcaggaga tgctggcgaa cctgtcgctc      180

tcggcgcggc tcgtcaagca tccgctgctc gcggtgcgac ccgtgcggcg catcggctac      240

ctcgtcatca cggccgatcg cggcctggcc gggccgtaca acgcgcaggt ggtgcgcgcc      300

gcgatgcagg attttggcaa gcgagacaag ggctcgtacg ccatttacac ggtcggcaag      360

cgagggcgga actttttcca gcgccgtggg ctgccgatcg cggccgaggt cgtcgatctc      420

cccgacacgc ccacgtatca ctccgtgcgc catctggcgg agaacatcgt cgcggcgtac      480

gagcgcgagg agttcgacga gctgtatttc atctacaacg agttcatcaa cgcggcggtt      540

caacgcccgg tggtgcgcaa agtgctgcct cttgcctccc ttggcgagaa cgtgcagggg      600

ccacggcgca actatctgtt cgagcccgac gaggagtcgg tgctggcggc tctccttccg      660

cggtatgccg agacgctggt gtatcaggcg gtgttggacg cgaaggcttc cgaacatgct      720

gcgcgcatga atgcgatggg caacgcgacc gacaacgcgc ttgagctgat cgagaaactg      780

acgctgtcgt tgaaccgggc gcgccaggcg gcgatcacga cccagatcgc ggaaattgtc      840

ggtggcgcgg aagcgttgaa ataa                                             864


<210>   1119
<211>   864
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1107

<400>   1119
atggcgcaaa acagcatgcg cgacatccgg cggcgcatca agagcgtccg gaatactgcg       60

cagatcacga aggcgatgga gatggtcgcg gccgccaagc tgcgccgcgt gcaggatgcg      120

gttcagcagt cgaagccgta cctctcgaag atgcaggaga tgctggcgaa cctgtcgctc      180

tcggcgcggc tcgtcaagca tccgctgctc gcggtgcgac ccgtgcggcg cttaggctac      240

ctcgtcatca cggccgatcg cggcctggcc gggccgtaca acgcgcaggt ggtgcgcgcc      300

gcgatgcagg agtttggcaa gcgagacaag ggctcgtacg ccatttacac ggtcggcaag      360

cgagggcgga actttttcca gcgccgtggg ctgccgatcg cggccgaggt cgtcgatctc      420

cccgacacgc ccacgtatca ctccgtgcgc catctggcgg agaacatcgt cgcggcgtac      480

gagcgcgagg agttcgacga gctgtatttc atctacaacg agttcatcaa cgcggcggtt      540

caacgcccgg tggtgcgcaa agtgctgcct cttgcctccc ttggcgagaa cgtgcagggg      600

ccacggcgca actatctgtt cgagcccgac gaggagtcgg tgctggcggc tctccttccg      660

cggtatgccg agacgctggt gtatcaggcg gtgttggacg cgaaggcttc cgaacatgct      720

gcgcgcatga atgcgatggg caacgcgacc gacaacgcgc ttgagctgat cgagaaactg      780

acgctgtcgt tgaaccgggc gcgccaggcg gcgatcacga cccagatcgc ggaaattgtc      840

ggtggcgcgg aagcgttgaa ataa                                             864


<210>   1120
<211>   864
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1107

<400>   1120
atggcgcaaa acagcatgcg cgacatccgg cggcgcatca agagcgtccg gaatactgcg       60

cagatcacga aggcgatgga gatggtcgcg gccgccaagc tgcgccgcgt gcaggatgcg      120

gttcagaatt cgaagccgta cctctcgaag atgcaggaga tgctggcgaa cctgtcgctc      180

tcggcgcggc tcgtcaagca tccgctgctc gcggtgcgac ccgtgcggcg catcggctac      240

ctcgtcatca cggccgatcg cggcctggcc gggccgtaca acgcgcaggt ggtgcgcgcc      300

gcgatgcagg agtttggcaa gcgagacaag ggctcgtacg ccatttacac ggtcggcaag      360

cgagggcgga actttttcca gcgccgtggg ctgccgatcg cggccgaggt cgtcgatctc      420

cccgacacgc ccacgtatca ctccgtgcgc catctggcgg agaacatcgt cgcggcgtac      480

gagcgcgagg agttcgacga gctgtatttc atctacaacg agttcatcaa cgcggcggtt      540

caacgcccgg tggtgcgcaa agtgctgcct cttgcctccc ttggcgagaa cgtgcagggg      600

ccacggcgca actatctgtt cgagcccgac gaggagtcgg tgctggcggc tctccttccg      660

cggtatgccg agacgctggt gtatcaggcg gtgttggacg cgaaggcttc cgaacatgct      720

gcgcgcatga atgcgatggg caacgcgacc gacaacgcgc ttgagctgat cgagaaactg      780

acgctgtcgt tgaaccgggc gcgccaggcg gcgatcacga cccagatcgc ggaaattgtc      840

ggtggcgcgg aagcgttgaa ataa                                             864


<210>   1121
<211>   864
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1107

<400>   1121
atggcgcaaa acagcatgcg cgacatccgg cggcgcatca agagcgtccg gaatactgcg       60

cagatcacga aggcgatgga gatggtcgcg gccgccaagc tgcgccgcgt gcaggatgcg      120

gttcagcagt cgaagccgta cctctcgaag atgcaggaga tgctggcgaa cctgtcgctc      180

tcggcgcggc tcgtcaagca tccgctgctc gcggtgcgac ccgtgcggcg catcggctac      240

ctcgtcatca cggccgatcg cggcctggcc gggccgtaca acgcgcaggt ggtgcgcgcc      300

gcgatgcagg agtttggcaa gcgagacaag ggctcgtacg ccatttacac ggtcggcaag      360

cgagggcgga actttttcca gcgccgtggg ctgccgatcg cggccgaggt cgtcgatctc      420

cccgacacgc ccacgtatca ctccgtgcgc catctggcgg agaacatcgt cgcggcgtac      480

gagcgcgagg agttcgacga gctgtatttc atctacaacg agttcatcaa cgcggcggtt      540

caacgcccgg tgattcgcaa agtgctgcct cttgcctccc ttggcgagaa cgtgcagggg      600

ccacggcgca actatctgtt cgagcccgac gaggagtcgg tgctggcggc tctccttccg      660

cggtatgccg agacgctggt gtatcaggcg gtgttggacg cgaaggcttc cgaacatgct      720

gcgcgcatga atgcgatggg caacgcgacc gacaacgcgc ttgagctgat cgagaaactg      780

acgctgtcgt tgaaccgggc gcgccaggcg gcgatcacga cccagatcgc ggaaattgtc      840

ggtggcgcgg aagcgttgaa ataa                                             864


<210>   1122
<211>   864
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1107

<400>   1122
atggcgcaaa acagcatgcg cgacatccgg cggcgcatca agagcgtccg gaatactgcg       60

cagatcacga aggcgatgga gatggtcgcg gccgccaagc tgcgccgcgt gcaggatgcg      120

gttcagcagt cgaagccgta cctctcgaag atgcaggaga tgctggcgaa cctgtcgctc      180

tcggcgcggc tcgtcaagca tccgctgctc gcggtgcgac ccgtgcggcg catcggctac      240

ctcgtcatca cggccgatcg cggcctggcc gggccgtaca acgcgcaggt ggtgcgcgcc      300

gcgatgcagg agtttggcaa gcgagacaag ggctcgtacg ccatttacac ggtcggcaag      360

cgagggcgga actttttcca gcgccgtggg ctgccgatcg cggccgaggt cgtcgatctc      420

cccgacacgc ccacgtatca ctccgtgcgc catctggcgg agaacatcgt cgcggcgtac      480

gagcgcgagg agttcgacga gctgtatttc atctacaacg agttcatcaa cgcggcggtt      540

caacgcccgg tggtgcgcaa agtgctgcct cttgcctccc ttggcgagaa cgtgcagggg      600

ccacggcgca actatctgtt cgagcccgac gaggagtcgg tgctggcggc tctccttccg      660

cggtatgccg agacgctggt gtatcaggcg gtgttggacg cgaaggcttc cgaacatgct      720

gcgcgcatga atgcgatggg caacgcgacc gacaacgcgc ttgagctgat cgagaaactg      780

acgctgtcgt tgaaccgggc gcgccaggcg gcgatcacga cccagatcgc ggaaattgtc      840

ggtggcgcgg atgcgttgaa ataa                                             864


<210>   1123
<211>   596
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1123
Met Leu Thr Arg Ala Trp Glu Gly Ile Asp Val Ala Asn Thr Ser Ile 
                5                   10                  15      

Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Thr Thr Ile Lys Val 
            20                  25                  30          

Ala Glu Ala Gly Val Pro Val Lys Leu Phe Ser Leu Val Pro Val Lys 
        35                  40                  45              

Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val Asn 
    50                  55                  60                  

Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr Ile 
65                  70                  75                  80  

Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Leu Gly Met Cys 
                85                  90                  95      

Glu Ala Ala Pro Ala Ile Ile Tyr Leu Met Asp Arg Met Gly Val Met 
            100                 105                 110         

Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly Gly 
        115                 120                 125             

Thr Lys His His Arg Thr Ala Phe Ala Gly Ala Ser Thr Gly Gln Gln 
    130                 135                 140                 

Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg Tyr Glu Val Ala Gly 
145                 150                 155                 160 

Leu Val Glu Lys Tyr Glu Gly Trp Asp Phe Leu Gly Ala Val Ile Asp 
                165                 170                 175     

Asp Glu Gln Ile Cys Arg Gly Ile Val Ala Gln Asp Leu Arg Ser Met 
            180                 185                 190         

Glu Ile His Tyr Phe Arg Ala Asp Ala Val Val Met Cys Thr Gly Gly 
        195                 200                 205             

Asn Gly Leu Ile Phe Gly Lys Ser Thr Asn Ser Met Ile Asn Thr Gly 
    210                 215                 220                 

Ser Ala Ala Ser Glu Leu Tyr Gln Gln Gly Val Lys Tyr Ala Asn Pro 
225                 230                 235                 240 

Glu Met Ile Gln Val His Pro Thr Ala Ile Pro Gly Asp Asp Lys Leu 
                245                 250                 255     

Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Val Trp Thr 
            260                 265                 270         

Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Trp Tyr Pro Glu 
        275                 280                 285             

Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Thr Arg Ala Ile His Lys 
    290                 295                 300                 

Val Cys Val Glu Met Gly Leu Gly Val Asp Gly Gln Asn Met Val Tyr 
305                 310                 315                 320 

Leu Asp Leu Thr His Ile Pro Ala Asp Val Leu Asp Arg Lys Leu Gly 
                325                 330                 335     

Asn Ile Leu Asp Ile Tyr Glu Lys Phe Val Gly Asp Asp Pro Arg Lys 
            340                 345                 350         

Val Pro Met Lys Ile Phe Pro Ala Val His Tyr Ser Met Gly Gly Leu 
        355                 360                 365             

Trp Val Asp Tyr Asp Gln Met Thr Asn Ile Pro Gly Leu Phe Ala Ala 
    370                 375                 380                 

Gly Glu Ala Asp Tyr Gln Tyr His Gly Ala Asn Arg Leu Gly Ala Asn 
385                 390                 395                 400 

Ser Leu Val Ser Cys Ile Tyr Gly Gly Met Ile Ala Gly Pro Asn Ala 
                405                 410                 415     

Val Arg Trp Ala Lys Asn Leu Arg Lys Ser Ala Asp Ser Leu Pro Glu 
            420                 425                 430         

Ser Leu Phe Glu Gln Tyr Arg Arg Lys Tyr Glu Gln Glu Phe Glu Glu 
        435                 440                 445             

Ile Leu Lys Leu Asp Gly Asp Glu Asn Pro Tyr Gln Leu His Arg Glu 
    450                 455                 460                 

Leu Gly Lys Trp Met Thr Asp His Val Thr Val Val Arg Tyr Asn Asp 
465                 470                 475                 480 

Lys Leu Lys Glu Thr Asp Ala Lys Ile Gln Glu Leu Gln Glu Arg Trp 
                485                 490                 495     

Lys Arg Ile Lys Met Ser Asp Thr Ser Arg Trp Glu Asn Gln Val Ala 
            500                 505                 510         

Gln Phe Thr Arg His Leu Lys Asn Met Leu Ile Met Ala Arg Ala Ile 
        515                 520                 525             

Thr Ile Gly Ala Leu Met Arg Asn Glu Ser Arg Gly Ala His Tyr Lys 
    530                 535                 540                 

Pro Glu Phe Pro Glu Arg Asp Asp Glu Asn Phe Leu Lys Thr Thr Ile 
545                 550                 555                 560 

Ala Glu Tyr Thr Pro Asp Gly Pro Lys Ile Ser Tyr Glu Asp Val Asp 
                565                 570                 575     

Val Ser Leu Ile Lys Pro Arg Lys Arg Asn Tyr Ala Val Ser Lys Glu 
            580                 585                 590         

Ala Thr Lys Glu 
        595     

<210>   1124
<211>   1791
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1124
gtgcttacgc gagcatggga gggaattgac gtggcaaaca cgagcatcat tgtcgtggga       60

ggcggcctgg ccggcctgat gaccaccatc aaggtggcgg aagctggcgt gccggtgaaa      120

ctgttctcct tggtacctgt aaaacgttcc cattccgtgt gtgctcaagg cggcatcaac      180

ggcgccgtga acacgaaggg cgagggcgac tcgccgtggg agcacttcga cgacaccatc      240

tacggcggcg actttctggc caaccagcct ccggttctgg gcatgtgcga ggccgcgccg      300

gccatcatct atttgatgga ccgcatgggc gtcatgttca accgcacgcc ggaaggactg      360

cttgacttcc gccggttcgg cggcacgaag catcaccgca cggcgttcgc gggcgcctcg      420

acagggcagc aactgcttta cgcgttggac gaacaggttc gccgatatga agtggctggc      480

ctcgtcgaga aatacgaggg atgggacttc ctcggcgccg tgatcgacga cgagcagatc      540

tgccgcggca ttgtggcgca ggacctgcgg tccatggaga tccactactt ccgcgccgat      600

gcggtggtca tgtgcaccgg gggcaacgga ctcattttcg gcaagagcac caactcgatg      660

atcaacacgg gttcggcggc atcggagctg taccagcagg gcgtcaagta cgcgaatccg      720

gagatgatcc aggttcaccc gacggccatc cccggggacg acaagctccg cctcatgtct      780

gagtccgcgc gcggcgaggg aggccgcgtc tggacgtaca aggacggcaa gccttggtac      840

ttcctggagg agtggtatcc cgagtacgga aacctggtgc cccgcgacat cgcgacgcgc      900

gccattcaca aggtctgcgt ggagatgggg cttggcgtcg acgggcaaaa catggtctat      960

ctcgacctga cccacatccc ggcggacgtg ctggatcgca agctgggcaa cattctcgat     1020

atctatgaga agttcgtcgg agacgatccg cgcaaggttc cgatgaagat cttccctgct     1080

gtgcactatt cgatgggcgg actgtgggtc gactacgacc agatgaccaa catcccgggc     1140

ctgttcgccg cgggcgaggc cgattatcaa taccacggcg cgaaccgcct cggcgcaaac     1200

tcgctcgtgt cctgcattta cggcggcatg atcgcgggtc cgaacgccgt gcgctgggcg     1260

aagaatctgc gcaagtccgc ggatagcctg cccgagtcgc tgttcgagca gtaccgccgc     1320

aagtacgagc aggaattcga ggaaattctc aagctcgacg gcgacgagaa cccgtaccag     1380

ttgcaccgcg aacttggcaa gtggatgacg gatcacgtca cggtggtgcg ctacaacgac     1440

aagctcaagg agacggacgc caagatccag gagcttcagg agcgctggaa gcggatcaag     1500

atgtcggaca cgtcgcgctg ggagaaccag gtcgcccagt tcacgcgcca cctgaagaat     1560

atgctcatta tggcgcgcgc catcaccatc ggagcgctga tgagaaacga gagccgtggc     1620

gcacactaca agccggagtt cccagagcgc gacgacgaga acttcctgaa gacgaccatc     1680

gccgagtaca cgccggacgg gccgaagatc tcgtacgagg acgtcgacgt ctcgctgatc     1740

aagccgcgta agcgcaacta cgcggtgagc aaggaggcga ccaaggaatg a              1791


<210>   1125
<211>   580
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1125
Ile Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Ala Thr Ile Lys 
                5                   10                  15      

Ile Ala Glu Ala Gly Val Pro Val Glu Leu Phe Ser Leu Val Pro Val 
            20                  25                  30          

Lys Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val 
        35                  40                  45              

Asn Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr 
    50                  55                  60                  

Val Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Lys Ala Met 
65                  70                  75                  80  

Cys Glu Ala Ala Pro Gly Ile Ile Tyr Met Leu Asp Arg Met Gly Val 
                85                  90                  95      

Met Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly 
            100                 105                 110         

Gly Thr Gln His His Arg Thr Ala Tyr Ala Gly Ala Thr Thr Gly Gln 
        115                 120                 125             

Gln Ile Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg His Glu Val Ala 
    130                 135                 140                 

Gly Leu Val Thr Lys Tyr Glu His Trp Glu Phe Leu Gly Val Val Leu 
145                 150                 155                 160 

Asp Asp Glu Gln Ile Cys Arg Gly Ile Val Ala Gln Asp Leu Arg Ser 
                165                 170                 175     

Met Glu Ile Lys Ala Phe Pro Ala Asp Ala Val Ile Leu Ala Thr Gly 
            180                 185                 190         

Gly Pro Gly Ile Ile Phe Gly Lys Ser Thr Asn Ser Val Ile Asn Thr 
        195                 200                 205             

Gly Ser Ala Ala Ser Ile Ala Tyr Gln Gln Gly Val Tyr Tyr Ala Asn 
    210                 215                 220                 

Gly Glu Phe Ile Gln Ile His Pro Thr Ala Ile Pro Gly Asp Asp Lys 
225                 230                 235                 240 

Leu Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Ile Trp 
                245                 250                 255     

Thr Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Lys Tyr Pro 
            260                 265                 270         

Ala Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Ala Arg Glu Ile Phe 
        275                 280                 285             

His Val Cys Val Asp Leu Lys Leu Gly Ile Asn Gly Glu Asn Met Val 
    290                 295                 300                 

Tyr Leu Asp Leu Ser His Lys Asp Pro Lys Glu Leu Asp Val Lys Leu 
305                 310                 315                 320 

Gly Gly Ile Ile Glu Ile Tyr Glu Lys Phe Met Gly Glu Asp Pro Arg 
                325                 330                 335     

Lys Val Pro Met Lys Val Phe Pro Ala Val His Tyr Ser Met Gly Gly 
            340                 345                 350         

Leu Trp Val Asp Tyr Asp Gln Met Thr Asn Ile Lys Gly Leu Phe Ala 
        355                 360                 365             

Ala Gly Glu Cys Asp Tyr Ser Ile His Gly Ala Asn Arg Leu Gly Ala 
    370                 375                 380                 

Asn Ser Leu Leu Ser Ala Ile Tyr Gly Gly Met Val Ala Gly Pro Asn 
385                 390                 395                 400 

Ala Val Arg Tyr Ile Arg Gly Leu Glu Lys Ser Ala Asp Ala Met Pro 
                405                 410                 415     

Ser Thr Leu Tyr Asp Ser Tyr Val Lys Arg Glu Gln Glu Lys Trp Glu 
            420                 425                 430         

Asn Ile Leu Ala Met Asp Gly Thr Glu Asn Ala Tyr Val Leu His Lys 
        435                 440                 445             

Glu Leu Gly Glu Trp Met Thr Ala Asn Val Thr Ile Val Arg Tyr Asn 
    450                 455                 460                 

Asp Arg Leu Leu Lys Thr Asp Glu Lys Ile Gln Glu Leu Met Glu Arg 
465                 470                 475                 480 

Tyr Lys Asn Ile Ser Val Thr Asp Thr Ser Arg Trp Ser Asn Gln Gly 
                485                 490                 495     

Ala Thr Phe Ile Arg Gln Leu Tyr Asn Met Leu Gln Leu Ala Arg Val 
            500                 505                 510         

Ile Thr Leu Gly Ala Tyr His Arg Asn Glu Ser Arg Gly Ala His Tyr 
        515                 520                 525             

Lys Pro Glu Phe Pro Glu Arg Asn Asp Glu Glu Trp Leu Lys Thr Thr 
    530                 535                 540                 

Met Ala Arg Tyr Thr Pro Asp Gly Pro Ala Phe His Tyr Glu Asp Val 
545                 550                 555                 560 

Asp Val Ser Leu Ile Lys Pro Arg Lys Arg Asp Tyr Ser Lys Lys Lys 
                565                 570                 575     

Glu Glu Val Lys 
            580 

<210>   1126
<211>   580
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1126
Ile Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Ala Thr Ile Lys 
                5                   10                  15      

Ile Ala Glu Ala Gly Val Pro Val Glu Leu Phe Ser Leu Val Pro Val 
            20                  25                  30          

Lys Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val 
        35                  40                  45              

Asn Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr 
    50                  55                  60                  

Val Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Lys Ala Met 
65                  70                  75                  80  

Cys Glu Ala Ala Pro Gly Ile Ile Tyr Met Leu Asp Arg Met Gly Val 
                85                  90                  95      

Met Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly 
            100                 105                 110         

Gly Thr Gln His His Arg Thr Ala Tyr Ala Gly Ala Thr Thr Gly Gln 
        115                 120                 125             

Gln Ile Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg His Glu Val Ala 
    130                 135                 140                 

Gly Leu Val Thr Lys Tyr Glu His Trp Glu Phe Leu Gly Val Val Leu 
145                 150                 155                 160 

Asp Asp Glu Gln Ile Cys Arg Gly Ile Val Ala Gln Asp Leu Arg Ser 
                165                 170                 175     

Met Glu Ile Lys Ala Phe Pro Ala Asp Ala Val Ile Leu Ala Thr Gly 
            180                 185                 190         

Gly Pro Gly Ile Ile Phe Gly Lys Ser Thr Asn Ser Val Ile Asn Thr 
        195                 200                 205             

Gly Ser Ala Ala Ser Ile Ala Tyr Gln Gln Gly Val Tyr Tyr Ala Asn 
    210                 215                 220                 

Gly Glu Phe Ile Gln Ile His Pro Thr Ala Ile Pro Gly Asp Asp Lys 
225                 230                 235                 240 

Leu Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Val Trp 
                245                 250                 255     

Thr Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Lys Tyr Pro 
            260                 265                 270         

Ala Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Ala Arg Glu Ile Phe 
        275                 280                 285             

His Val Cys Val Asp Leu Lys Leu Gly Ile Asn Gly Glu Asn Met Val 
    290                 295                 300                 

Tyr Leu Asp Leu Ser His Lys Asp Pro Lys Glu Leu Asp Val Lys Leu 
305                 310                 315                 320 

Gly Gly Ile Ile Glu Ile Tyr Glu Lys Phe Met Gly Glu Asp Pro Arg 
                325                 330                 335     

Lys Val Pro Met Lys Val Phe Pro Ala Val His Tyr Ser Met Gly Gly 
            340                 345                 350         

Leu Trp Val Asp Tyr Asp Gln Met Thr Asn Ile Lys Gly Leu Phe Ala 
        355                 360                 365             

Ala Gly Glu Cys Asp Tyr Ser Ile His Gly Ala Asn Arg Leu Gly Ala 
    370                 375                 380                 

Asn Ser Leu Leu Ser Ala Ile Tyr Gly Gly Met Val Ala Gly Pro Asn 
385                 390                 395                 400 

Ala Val Arg Tyr Ile Arg Gly Leu Glu Lys Ser Ala Asp Ala Leu Pro 
                405                 410                 415     

Ser Thr Leu Phe Asp Ser Tyr Val Lys Gln Glu Gln Glu Lys Trp Glu 
            420                 425                 430         

Asn Ile Leu Ser Met Asp Gly Thr Glu Asn Ala Tyr Val Leu His Lys 
        435                 440                 445             

Glu Leu Gly Glu Trp Met Thr Ala Asn Val Thr Ile Val Arg Tyr Asn 
    450                 455                 460                 

Asp Arg Leu Leu Lys Thr Asp Glu Lys Ile Gln Glu Leu Met Glu Arg 
465                 470                 475                 480 

Tyr Lys Asn Ile Ser Val Thr Asp Thr Ala Lys Trp Ser Asn Gln Gly 
                485                 490                 495     

Ala Thr Phe Ile Arg Gln Leu Tyr Asn Met Leu Gln Leu Ala Arg Val 
            500                 505                 510         

Ile Thr Leu Gly Ala Tyr Asn Arg Asn Glu Ser Arg Gly Ala His Tyr 
        515                 520                 525             

Lys Pro Glu Phe Pro Glu Arg Asn Asp Lys Glu Trp Leu Lys Thr Thr 
    530                 535                 540                 

Met Ala Arg Tyr Thr Pro Asp Gly Pro Ser Phe His Tyr Glu Asp Val 
545                 550                 555                 560 

Asp Val Ser Leu Ile Lys Pro Arg Lys Arg Asp Tyr Ser Lys Lys Lys 
                565                 570                 575     

Glu Glu Val Lys 
            580 

<210>   1127
<211>   581
<212>   PRT
<213>   Paenibacillus macerans

<400>   1127
Met Ala Lys Gln Ser Val Ile Val Val Gly Gly Gly Leu Ala Gly Leu 
                5                   10                  15      

Met Ala Thr Ile Lys Ser Ala Glu Ala Gly Val Pro Val His Leu Phe 
            20                  25                  30          

Ser Leu Val Pro Val Lys Arg Ser His Ser Val Cys Ala Gln Gly Gly 
        35                  40                  45              

Ile Asn Gly Ala Val Asn Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu 
    50                  55                  60                  

His Phe Asp Asp Thr Val Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro 
65                  70                  75                  80  

Pro Val Lys Ala Met Cys Glu Ala Ala Pro Gly Ile Ile His Leu Met 
                85                  90                  95      

Asp Arg Met Gly Val Met Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp 
            100                 105                 110         

Phe Arg Arg Phe Gly Gly Thr Lys His His Arg Thr Ala Phe Ala Gly 
        115                 120                 125             

Ala Thr Thr Gly Gln Gln Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg 
    130                 135                 140                 

Arg His Glu Ala Ala Gly Leu Val Thr Lys Tyr Glu Asn Trp Glu Phe 
145                 150                 155                 160 

Leu Ser Val Val Leu Asp Asp Asp Gly Val Cys Arg Gly Ile Thr Ala 
                165                 170                 175     

Gln Asn Leu Arg Ser Met Glu Ile Val Thr Phe Ala Ser Asp Ala Val 
            180                 185                 190         

Ile Leu Ala Thr Gly Gly Pro Gly Ile Ile Phe Gly Lys Thr Thr Asn 
        195                 200                 205             

Ser Val Ile Asn Thr Gly Thr Ala Ala Ser Ala Val Tyr Gln Gln Gly 
    210                 215                 220                 

Val His Tyr Ala Asn Gly Glu Phe Ile Gln Ile His Pro Thr Ala Ile 
225                 230                 235                 240 

Pro Gly Asp Asp Lys Leu Arg Leu Met Ser Glu Ser Ala Arg Gly Glu 
                245                 250                 255     

Gly Gly Arg Ile Trp Thr Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu 
            260                 265                 270         

Glu Glu Lys Tyr Pro Ala Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala 
        275                 280                 285             

Thr Arg Glu Ile Phe His Val Cys Val Asp Gln Lys Leu Gly Ile Asn 
    290                 295                 300                 

Gly Glu Asn Met Val Tyr Leu Asp Leu Ser His Lys Asp Pro Lys Glu 
305                 310                 315                 320 

Leu Asp Val Lys Leu Gly Gly Ile Ile Glu Ile Tyr Glu Lys Phe Met 
                325                 330                 335     

Gly Asp Asp Pro Arg Lys Ile Pro Met Lys Ile Phe Pro Ala Val His 
            340                 345                 350         

Tyr Ser Met Gly Gly Met Trp Val Asp Tyr Asn Gln Met Thr Asn Ile 
        355                 360                 365             

Pro Gly Leu Phe Ala Ala Gly Glu Cys Glu Tyr Gln Tyr His Gly Ala 
    370                 375                 380                 

Asn Arg Leu Gly Ala Asn Ser Leu Val Ser Ala Ile Tyr Gly Gly Met 
385                 390                 395                 400 

Val Ala Gly Pro Lys Ala Val Glu Tyr Ile Arg Gly Leu Lys Lys Ser 
                405                 410                 415     

Ala Asp Asp Ile Arg Pro Asp Val Phe Asp Arg Tyr Arg Lys Ala Gln 
            420                 425                 430         

Glu Asp Lys Phe Glu Gly Leu Leu Asn Met Asn Gly Ser Glu Asn Ala 
        435                 440                 445             

Tyr Val Leu His Lys Glu Leu Gly Glu Trp Met Thr Asp Asn Met Thr 
    450                 455                 460                 

Val Val Arg Tyr Asn Asp Arg Leu Glu Ala Thr Ile Asn Lys Ile Lys 
465                 470                 475                 480 

Glu Leu Lys Glu Arg Tyr Lys Lys Ile Asn Ile Asn Asp Thr Ser Arg 
                485                 490                 495     

Trp Asn Asn Ala Gly Ala Ala Phe Thr Arg Gln Leu Trp Asn Met Leu 
            500                 505                 510         

Glu Leu Ala Glu Ala Met Thr Leu Gly Ala Leu Leu Arg Asn Glu Ser 
        515                 520                 525             

Arg Gly Ala His Tyr Lys Pro Asp Phe Pro Asn Arg Asn Asp Glu Glu 
    530                 535                 540                 

Phe Leu Lys Thr Thr Lys Ala Thr Trp Thr Pro Asp Gly Pro Gln Ile 
545                 550                 555                 560 

Ser Tyr Glu Asp Val Asp Val Ser Leu Ile Pro Pro Arg Ile Arg Asp 
                565                 570                 575     

Tyr Ser Lys Asp Lys 
            580     

<210>   1128
<211>   585
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1128
Met Ser Asn Ser Ser Ile Ile Val Val Gly Gly Gly Leu Ala Gly Leu 
                5                   10                  15      

Met Ala Thr Ile Lys Ala Ala Glu Ala Gly Thr Asn Val Lys Leu Phe 
            20                  25                  30          

Ser Ile Val Pro Val Lys Arg Ser His Ser Val Cys Ala Gln Gly Gly 
        35                  40                  45              

Ile Asn Gly Ala Val Asn Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu 
    50                  55                  60                  

His Phe Asp Asp Thr Val Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro 
65                  70                  75                  80  

Pro Val Lys Ala Met Cys Glu Ala Ala Pro Ser Ile Ile His Leu Leu 
                85                  90                  95      

Asp Arg Met Gly Val Met Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp 
            100                 105                 110         

Phe Arg Arg Phe Gly Gly Thr Gln His His Arg Thr Ala Tyr Ala Gly 
        115                 120                 125             

Ala Thr Thr Gly Gln Gln Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg 
    130                 135                 140                 

Arg Phe Glu Val Glu Gly Leu Val Ser Lys Tyr Glu Gly Trp Glu Phe 
145                 150                 155                 160 

Leu Gly Ala Val Leu Asp Asp Asp Asn Thr Cys Arg Gly Ile Val Ala 
                165                 170                 175     

Gln Asn Leu Thr Thr Met Glu Ile Glu Ser Phe Arg Ser Asp Ala Val 
            180                 185                 190         

Ile Met Ala Thr Gly Gly Pro Gly Ile Ile Phe Gly Lys Ser Thr Asn 
        195                 200                 205             

Ser Met Ile Asn Thr Gly Ser Ala Ala Ser Ile Val Tyr Gln Gln Gly 
    210                 215                 220                 

Ala Tyr Tyr Ala Asn Gly Glu Phe Ile Gln Ile His Pro Thr Ala Ile 
225                 230                 235                 240 

Pro Gly Asp Asp Lys Leu Arg Leu Met Ser Glu Ser Ala Arg Gly Glu 
                245                 250                 255     

Gly Gly Arg Val Trp Thr Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu 
            260                 265                 270         

Glu Glu Lys Tyr Pro Ala Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala 
        275                 280                 285             

Thr Arg Glu Ile Phe Asp Val Cys Val Arg Gln Lys Leu Gly Ile Asn 
    290                 295                 300                 

Gly Glu Asn Met Val Tyr Leu Asp Leu Ser His Lys Asp Pro Lys Glu 
305                 310                 315                 320 

Leu Asp Ile Lys Leu Gly Gly Ile Ile Glu Ile Tyr Glu Lys Phe Met 
                325                 330                 335     

Gly Asp Asp Pro Arg Lys Leu Pro Met Lys Ile Phe Pro Ala Val His 
            340                 345                 350         

Tyr Ser Met Gly Gly Leu Trp Val Asp Tyr Asp Gln Met Thr Asn Ile 
        355                 360                 365             

Pro Gly Leu Phe Ala Ala Gly Glu Cys Asp Tyr Ser Met His Gly Gly 
    370                 375                 380                 

Asn Arg Leu Gly Ala Asn Ser Leu Leu Ser Ala Ile Tyr Gly Gly Met 
385                 390                 395                 400 

Val Ala Gly Pro Lys Ala Val Glu Tyr Ile Gln Gly Leu Glu Thr Ser 
                405                 410                 415     

Ala Glu Asp Leu Ser Ser Ser Val Phe Asp Ala Tyr Val Lys Lys Glu 
            420                 425                 430         

Glu Glu Lys Trp Ala Asp Ile Met Lys Met Asp Gly Asn Glu Asn Ala 
        435                 440                 445             

Tyr Val Leu His Lys Glu Leu Gly Glu Trp Met Thr Asp Asn Val Thr 
    450                 455                 460                 

Val Val Arg Tyr Asn Asp Lys Leu Leu Lys Thr Asp Glu Lys Ile Gln 
465                 470                 475                 480 

Glu Leu Ala Glu Arg Tyr Arg Asn Ile Asn Ile Asn Asp Thr Ala Lys 
                485                 490                 495     

Trp Ser Asn Gln Gly Ala Val Phe Thr Arg Gln Leu His Asn Met Leu 
            500                 505                 510         

Gln Leu Ala Arg Val Ile Thr Leu Gly Ala Tyr Asn Arg Asn Glu Ser 
        515                 520                 525             

Arg Gly Ala His Tyr Lys Pro Asp Phe Pro Glu Arg Asn Asp Glu Glu 
    530                 535                 540                 

Trp Leu Lys Thr Thr Met Ala Lys His Ala Gly Asp Phe Glu Ala Pro 
545                 550                 555                 560 

Lys Phe His Tyr Glu Asp Val Asp Val Ser Leu Ile Ala Pro Arg Lys 
                565                 570                 575     

Arg Asp Tyr Ser Lys Lys Lys Val Ala 
            580                 585 

<210>   1129
<211>   579
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1129
Val Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Ala Thr Ile Lys 
                5                   10                  15      

Val Ala Glu Ala Gly Val Pro Val Glu Leu Phe Ser Leu Val Pro Val 
            20                  25                  30          

Lys Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val 
        35                  40                  45              

Asn Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr 
    50                  55                  60                  

Val Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Lys Ala Met 
65                  70                  75                  80  

Cys Asp Ala Ala Pro Gly Ile Ile His Leu Met Asp Arg Met Gly Val 
                85                  90                  95      

Met Phe Asn Arg Thr Ala Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly 
            100                 105                 110         

Gly Thr Gln His His Arg Thr Ala Phe Ala Gly Ala Thr Thr Gly Gln 
        115                 120                 125             

Gln Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg His Glu Thr Ser 
    130                 135                 140                 

Gly Leu Val Thr Lys Tyr Glu Gly Trp Glu Phe Ile Ser Ala Ile Ile 
145                 150                 155                 160 

Asp Asp Glu Gly Ile Cys Arg Gly Ile Thr Ala Gln Asn Leu Lys Thr 
                165                 170                 175     

Ser Glu Phe Gln Ser Phe Ser Ala Asp Ala Val Ile Met Ala Thr Gly 
            180                 185                 190         

Gly Pro Gly Ile Ile Phe Gly Lys Ser Thr Asn Ser Val Ile Asn Thr 
        195                 200                 205             

Gly Tyr Ala Ala Ala Lys Leu Tyr Glu Gln Gly Val Tyr Tyr Ala Asn 
    210                 215                 220                 

Gly Glu Phe Ile Gln Ile His Pro Thr Ala Ile Pro Gly Asp Asp Lys 
225                 230                 235                 240 

Leu Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Val Trp 
                245                 250                 255     

Thr Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Lys Tyr Pro 
            260                 265                 270         

Ala Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Thr Arg Glu Ile Phe 
        275                 280                 285             

His Val Cys Val Asp Leu Lys Leu Gly Ile Asn Gly Glu Asn Met Val 
    290                 295                 300                 

Tyr Leu Asp Leu Ser His Lys Asp Pro Lys Glu Leu Asp Ile Lys Leu 
305                 310                 315                 320 

Gly Gly Ile Ile Glu Ile Tyr Glu Lys Phe Met Gly Asp Asp Pro Arg 
                325                 330                 335     

Lys Val Pro Met Lys Ile Phe Pro Ala Val His Tyr Ser Met Gly Gly 
            340                 345                 350         

Met Trp Ile Asp Tyr Asp Gln Met Thr Asn Ile Pro Gly Leu Phe Ala 
        355                 360                 365             

Ala Gly Glu Cys Asp Tyr Ser Gln His Gly Ala Asn Arg Leu Gly Ala 
    370                 375                 380                 

Asn Ser Leu Leu Ser Ala Ile Phe Gly Gly Met Val Ala Gly Pro Lys 
385                 390                 395                 400 

Ala Val Glu Tyr Met Asn Gly Leu Glu Lys Ser Ala Glu Ser Met Pro 
                405                 410                 415     

Ser Ser Leu Phe Glu Gly Glu Leu Lys Lys Glu Gln Glu Lys Phe Asp 
            420                 425                 430         

Asp Ile Leu Lys Met Asp Gly Lys Glu Asn Ala Tyr Val Leu His Lys 
        435                 440                 445             

Glu Leu Gly Glu Trp Met Thr Asp Asn Val Thr Val Val Arg Tyr Asn 
    450                 455                 460                 

Asp Lys Leu Leu Lys Thr Asp Glu Lys Ile Gln Glu Leu Met Glu Arg 
465                 470                 475                 480 

Tyr Lys Asn Ile Asp Ile Asn Asp Thr Ala Lys Trp Ser Asn Gln Gly 
                485                 490                 495     

Ala Ser Phe Thr Arg Gln Leu Asp Gly Met Leu Lys Leu Ala Arg Val 
            500                 505                 510         

Ile Thr Leu Gly Ala Tyr Asn Arg Asn Glu Ser Arg Gly Ala His Tyr 
        515                 520                 525             

Lys Pro Asp Phe Pro Glu Arg Asn Asp Glu Glu Phe Leu Lys Thr Thr 
    530                 535                 540                 

Lys Ala Lys Phe Asn Pro Glu Thr Leu Ala Pro Glu Phe Glu Tyr Glu 
545                 550                 555                 560 

Glu Val Asp Val Ser Leu Ile Glu Pro Arg Lys Arg Asp Tyr Ser Gln 
                565                 570                 575     

Lys Lys Gln 
            

<210>   1130
<211>   596
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1123

<400>   1130
Met Leu Thr Arg Ala Trp Glu Gly Ile Asp Val Ala Asn Thr Ser Ile 
                5                   10                  15      

Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Thr Thr Ile Lys Val 
            20                  25                  30          

Ala Glu Ala Gly Val Pro Val Lys Leu Phe Ser Leu Val Pro Val Lys 
        35                  40                  45              

Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val Asn 
    50                  55                  60                  

Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr Ile 
65                  70                  75                  80  

Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Leu Gly Met Cys 
                85                  90                  95      

Glu Ala Ala Pro Ala Ile Ile Tyr Leu Met Asp Arg Met Gly Val Met 
            100                 105                 110         

Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly Gly 
        115                 120                 125             

Thr Lys His His Arg Thr Ala Phe Ala Gly Ala Ser Thr Gly Gln Gln 
    130                 135                 140                 

Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg Tyr Glu Val Ala Gly 
145                 150                 155                 160 

Leu Val Glu Lys Tyr Glu Gly Trp Asp Phe Leu Gly Ala Val Ile Asp 
                165                 170                 175     

Asp Glu Gln Ile Cys Arg Gly Ile Val Ala Gln Asp Leu Arg Ser Met 
            180                 185                 190         

Glu Ile His Tyr Phe Arg Ala Asp Ala Val Val Met Cys Thr Gly Gly 
        195                 200                 205             

Asn Gly Leu Ile Phe Gly Lys Ser Thr Asn Ser Met Ile Asn Thr Gly 
    210                 215                 220                 

Ser Ala Ala Ser Asp Leu Tyr Gln Gln Gly Val Lys Tyr Ala Asn Pro 
225                 230                 235                 240 

Glu Met Ile Gln Val His Pro Thr Ala Ile Pro Gly Asp Asp Lys Leu 
                245                 250                 255     

Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Val Trp Thr 
            260                 265                 270         

Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Trp Tyr Pro Glu 
        275                 280                 285             

Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Thr Arg Ala Ile His Lys 
    290                 295                 300                 

Val Cys Val Glu Met Gly Leu Gly Val Asp Gly Gln Asn Met Val Tyr 
305                 310                 315                 320 

Leu Asp Leu Thr His Ile Pro Ala Asp Val Leu Asp Arg Lys Leu Gly 
                325                 330                 335     

Asn Ile Leu Asp Ile Tyr Glu Lys Phe Val Gly Asp Asp Pro Arg Lys 
            340                 345                 350         

Val Pro Met Lys Ile Phe Pro Ala Val His Tyr Ser Met Gly Gly Leu 
        355                 360                 365             

Trp Val Asp Tyr Asp Gln Met Thr Asn Ile Pro Gly Leu Phe Ala Ala 
    370                 375                 380                 

Gly Glu Ala Asp Tyr Gln Tyr His Gly Ala Asn Arg Leu Gly Ala Asn 
385                 390                 395                 400 

Ser Leu Val Ser Cys Ile Tyr Gly Gly Met Ile Ala Gly Pro Asn Ala 
                405                 410                 415     

Val Arg Trp Ala Lys Asn Leu Arg Lys Ser Ala Asp Ser Leu Pro Glu 
            420                 425                 430         

Ser Leu Phe Glu Gln Tyr Arg Arg Lys Tyr Glu Gln Glu Phe Glu Glu 
        435                 440                 445             

Ile Leu Lys Leu Asp Gly Asp Glu Asn Pro Tyr Gln Leu His Arg Glu 
    450                 455                 460                 

Leu Gly Lys Trp Met Thr Asp His Val Thr Val Val Arg Tyr Asn Asp 
465                 470                 475                 480 

Lys Leu Lys Glu Thr Asp Ala Lys Ile Gln Glu Leu Gln Glu Arg Trp 
                485                 490                 495     

Lys Arg Ile Lys Met Ser Asp Thr Ser Arg Trp Glu Asn Gln Val Ala 
            500                 505                 510         

Gln Phe Thr Arg His Leu Lys Asn Met Leu Ile Met Ala Arg Ala Ile 
        515                 520                 525             

Thr Ile Gly Ala Leu Met Arg Asn Glu Ser Arg Gly Ala His Tyr Lys 
    530                 535                 540                 

Pro Glu Phe Pro Glu Arg Asp Asp Glu Asn Phe Leu Lys Thr Thr Ile 
545                 550                 555                 560 

Ala Glu Tyr Thr Pro Asp Gly Pro Lys Ile Ser Tyr Glu Asp Val Asp 
                565                 570                 575     

Val Ser Leu Ile Lys Pro Arg Lys Arg Asn Tyr Ala Val Ser Lys Glu 
            580                 585                 590         

Ala Thr Lys Glu 
        595     

<210>   1131
<211>   596
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1123

<400>   1131
Met Leu Thr Arg Ala Trp Glu Gly Ile Asp Val Ala Gln Thr Ser Ile 
                5                   10                  15      

Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Thr Thr Ile Lys Val 
            20                  25                  30          

Ala Glu Ala Gly Val Pro Val Lys Leu Phe Ser Leu Val Pro Val Lys 
        35                  40                  45              

Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val Asn 
    50                  55                  60                  

Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr Ile 
65                  70                  75                  80  

Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Leu Gly Met Cys 
                85                  90                  95      

Glu Ala Ala Pro Ala Ile Ile Tyr Leu Met Asp Arg Met Gly Val Met 
            100                 105                 110         

Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly Gly 
        115                 120                 125             

Thr Lys His His Arg Thr Ala Phe Ala Gly Ala Ser Thr Gly Gln Gln 
    130                 135                 140                 

Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg Tyr Glu Val Ala Gly 
145                 150                 155                 160 

Leu Val Glu Lys Tyr Glu Gly Trp Asp Phe Leu Gly Ala Val Ile Asp 
                165                 170                 175     

Asp Glu Gln Ile Cys Arg Gly Ile Val Ala Gln Asp Leu Arg Ser Met 
            180                 185                 190         

Glu Ile His Tyr Phe Arg Ala Asp Ala Val Val Met Cys Thr Gly Gly 
        195                 200                 205             

Asn Gly Leu Ile Phe Gly Lys Ser Thr Asn Ser Met Ile Asn Thr Gly 
    210                 215                 220                 

Ser Ala Ala Ser Glu Leu Tyr Gln Gln Gly Val Lys Tyr Ala Asn Pro 
225                 230                 235                 240 

Glu Met Ile Gln Val His Pro Thr Ala Ile Pro Gly Asp Asp Lys Leu 
                245                 250                 255     

Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Val Trp Thr 
            260                 265                 270         

Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Trp Tyr Pro Glu 
        275                 280                 285             

Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Thr Arg Ala Ile His Lys 
    290                 295                 300                 

Val Cys Val Glu Met Gly Leu Gly Val Asp Gly Gln Asn Met Val Tyr 
305                 310                 315                 320 

Leu Asp Leu Thr His Ile Pro Ala Asp Val Leu Asp Arg Lys Leu Gly 
                325                 330                 335     

Asn Ile Leu Asp Ile Tyr Glu Lys Phe Val Gly Asp Asp Pro Arg Lys 
            340                 345                 350         

Val Pro Met Lys Ile Phe Pro Ala Val His Tyr Ser Met Gly Gly Leu 
        355                 360                 365             

Trp Val Asp Tyr Asp Gln Met Thr Asn Ile Pro Gly Leu Phe Ala Ala 
    370                 375                 380                 

Gly Glu Ala Asp Tyr Gln Tyr His Gly Ala Asn Arg Leu Gly Ala Asn 
385                 390                 395                 400 

Ser Leu Val Ser Cys Ile Tyr Gly Gly Met Ile Ala Gly Pro Asn Ala 
                405                 410                 415     

Val Arg Trp Ala Lys Asn Leu Arg Lys Ser Ala Asp Ser Leu Pro Glu 
            420                 425                 430         

Ser Leu Phe Glu Gln Tyr Arg Arg Lys Tyr Glu Gln Glu Phe Glu Glu 
        435                 440                 445             

Ile Leu Lys Leu Asp Gly Asp Glu Asn Pro Tyr Gln Leu His Arg Glu 
    450                 455                 460                 

Leu Gly Lys Trp Met Thr Asp His Val Thr Val Val Arg Tyr Asn Asp 
465                 470                 475                 480 

Lys Leu Lys Glu Thr Asp Ala Lys Ile Gln Glu Leu Gln Glu Arg Trp 
                485                 490                 495     

Lys Arg Ile Lys Met Ser Asp Thr Ser Arg Trp Glu Asn Gln Val Ala 
            500                 505                 510         

Gln Phe Thr Arg His Leu Lys Asn Met Leu Ile Met Ala Arg Ala Ile 
        515                 520                 525             

Thr Ile Gly Ala Leu Met Arg Asn Glu Ser Arg Gly Ala His Tyr Lys 
    530                 535                 540                 

Pro Glu Phe Pro Glu Arg Asp Asp Glu Asn Phe Leu Lys Thr Thr Ile 
545                 550                 555                 560 

Ala Glu Tyr Thr Pro Asp Gly Pro Lys Ile Ser Tyr Glu Asp Val Asp 
                565                 570                 575     

Val Ser Leu Ile Lys Pro Arg Lys Arg Asn Tyr Ala Val Ser Lys Glu 
            580                 585                 590         

Ala Thr Lys Glu 
        595     

<210>   1132
<211>   596
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1123

<400>   1132
Met Leu Thr Arg Ala Trp Glu Gly Ile Asp Val Ala Asn Thr Ser Ile 
                5                   10                  15      

Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Thr Thr Ile Lys Val 
            20                  25                  30          

Ala Glu Ala Gly Val Pro Val Lys Leu Phe Ser Leu Val Pro Val Lys 
        35                  40                  45              

Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val Asn 
    50                  55                  60                  

Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr Ile 
65                  70                  75                  80  

Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Leu Gly Met Cys 
                85                  90                  95      

Glu Ala Ala Pro Ala Ile Ile Tyr Leu Met Asp Arg Met Gly Val Met 
            100                 105                 110         

Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly Gly 
        115                 120                 125             

Thr Lys His His Arg Thr Ala Phe Ala Gly Ala Ser Thr Gly Gln Gln 
    130                 135                 140                 

Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg Tyr Glu Val Ala Gly 
145                 150                 155                 160 

Leu Val Glu Lys Tyr Glu Gly Trp Asp Phe Leu Gly Ala Val Ile Asp 
                165                 170                 175     

Asp Glu Gln Ile Cys Arg Gly Ile Val Ala Gln Asp Leu Arg Ser Met 
            180                 185                 190         

Glu Ile His Tyr Phe Arg Ala Asp Ala Val Val Met Cys Thr Gly Gly 
        195                 200                 205             

Asn Gly Leu Ile Phe Gly Lys Ser Thr Asn Ser Met Ile Asn Thr Gly 
    210                 215                 220                 

Ser Ala Ala Ser Glu Leu Tyr Gln Gln Gly Val Lys Tyr Ala Asn Pro 
225                 230                 235                 240 

Glu Met Ile Gln Val His Pro Thr Ala Ile Pro Gly Asp Asp Lys Leu 
                245                 250                 255     

Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Val Trp Thr 
            260                 265                 270         

Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Trp Tyr Pro Glu 
        275                 280                 285             

Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Thr Arg Ala Ile His Lys 
    290                 295                 300                 

Val Cys Val Glu Met Gly Leu Gly Val Asp Gly Gln Asn Met Val Tyr 
305                 310                 315                 320 

Leu Asp Leu Thr His Ile Pro Ala Asp Val Leu Asp Arg Lys Leu Gly 
                325                 330                 335     

Asn Ile Leu Asp Ile Tyr Glu Lys Phe Val Gly Asp Asp Pro Arg Lys 
            340                 345                 350         

Val Pro Met Lys Ile Phe Pro Ala Val His Tyr Ser Met Gly Gly Leu 
        355                 360                 365             

Trp Val Asp Tyr Asp Gln Met Thr Asn Ile Pro Gly Leu Phe Ala Ala 
    370                 375                 380                 

Gly Glu Ala Asp Tyr Gln Tyr His Gly Ala Asn Arg Leu Gly Ala Asn 
385                 390                 395                 400 

Ser Leu Val Ser Cys Ile Tyr Gly Gly Met Ile Ala Gly Pro Asn Ala 
                405                 410                 415     

Val Arg Trp Ala Lys Asn Leu Arg Lys Ser Ala Asp Ser Leu Pro Glu 
            420                 425                 430         

Ser Leu Phe Glu Gln Tyr Arg Arg Lys Tyr Glu Gln Glu Phe Glu Glu 
        435                 440                 445             

Ile Leu Lys Leu Asp Gly Asp Glu Asn Pro Tyr Gln Leu His Arg Glu 
    450                 455                 460                 

Leu Gly Lys Trp Met Thr Asp His Val Thr Val Val Arg Tyr Asn Asp 
465                 470                 475                 480 

Lys Leu Lys Asp Thr Asp Ala Lys Ile Gln Glu Leu Gln Glu Arg Trp 
                485                 490                 495     

Lys Arg Ile Lys Met Ser Asp Thr Ser Arg Trp Glu Asn Gln Val Ala 
            500                 505                 510         

Gln Phe Thr Arg His Leu Lys Asn Met Leu Ile Met Ala Arg Ala Ile 
        515                 520                 525             

Thr Ile Gly Ala Leu Met Arg Asn Glu Ser Arg Gly Ala His Tyr Lys 
    530                 535                 540                 

Pro Glu Phe Pro Glu Arg Asp Asp Glu Asn Phe Leu Lys Thr Thr Ile 
545                 550                 555                 560 

Ala Glu Tyr Thr Pro Asp Gly Pro Lys Ile Ser Tyr Glu Asp Val Asp 
                565                 570                 575     

Val Ser Leu Ile Lys Pro Arg Lys Arg Asn Tyr Ala Val Ser Lys Glu 
            580                 585                 590         

Ala Thr Lys Glu 
        595     

<210>   1133
<211>   596
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1123

<400>   1133
Met Leu Thr Arg Ala Trp Glu Gly Ile Asp Val Ala Asn Thr Ser Ile 
                5                   10                  15      

Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Thr Thr Ile Lys Val 
            20                  25                  30          

Ala Glu Ala Gly Val Pro Val Lys Leu Phe Ser Leu Val Pro Val Lys 
        35                  40                  45              

Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val Asn 
    50                  55                  60                  

Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr Ile 
65                  70                  75                  80  

Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Leu Gly Met Cys 
                85                  90                  95      

Glu Ala Ala Pro Ala Ile Ile Tyr Leu Met Asp Arg Met Gly Val Met 
            100                 105                 110         

Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly Gly 
        115                 120                 125             

Thr Lys His His Arg Thr Ala Phe Ala Gly Ala Ser Thr Gly Gln Gln 
    130                 135                 140                 

Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg Tyr Glu Val Ala Gly 
145                 150                 155                 160 

Leu Val Glu Lys Tyr Glu Gly Trp Asp Phe Leu Gly Ala Val Ile Asp 
                165                 170                 175     

Asp Glu Gln Ile Cys Arg Gly Ile Val Ala Gln Asp Leu Lys Ser Met 
            180                 185                 190         

Glu Ile His Tyr Phe Arg Ala Asp Ala Val Val Met Cys Thr Gly Gly 
        195                 200                 205             

Asn Gly Leu Ile Phe Gly Lys Ser Thr Asn Ser Met Ile Asn Thr Gly 
    210                 215                 220                 

Ser Ala Ala Ser Glu Leu Tyr Gln Gln Gly Val Lys Tyr Ala Asn Pro 
225                 230                 235                 240 

Glu Met Ile Gln Val His Pro Thr Ala Ile Pro Gly Asp Asp Lys Leu 
                245                 250                 255     

Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Val Trp Thr 
            260                 265                 270         

Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Trp Tyr Pro Glu 
        275                 280                 285             

Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Thr Arg Ala Ile His Lys 
    290                 295                 300                 

Val Cys Val Glu Met Gly Leu Gly Val Asp Gly Gln Asn Met Val Tyr 
305                 310                 315                 320 

Leu Asp Leu Thr His Ile Pro Ala Asp Val Leu Asp Arg Lys Leu Gly 
                325                 330                 335     

Asn Ile Leu Asp Ile Tyr Glu Lys Phe Val Gly Asp Asp Pro Arg Lys 
            340                 345                 350         

Val Pro Met Lys Ile Phe Pro Ala Val His Tyr Ser Met Gly Gly Leu 
        355                 360                 365             

Trp Val Asp Tyr Asp Gln Met Thr Asn Ile Pro Gly Leu Phe Ala Ala 
    370                 375                 380                 

Gly Glu Ala Asp Tyr Gln Tyr His Gly Ala Asn Arg Leu Gly Ala Asn 
385                 390                 395                 400 

Ser Leu Val Ser Cys Ile Tyr Gly Gly Met Ile Ala Gly Pro Asn Ala 
                405                 410                 415     

Val Arg Trp Ala Lys Asn Leu Arg Lys Ser Ala Asp Ser Leu Pro Glu 
            420                 425                 430         

Ser Leu Phe Glu Gln Tyr Arg Arg Lys Tyr Glu Gln Glu Phe Glu Glu 
        435                 440                 445             

Ile Leu Lys Leu Asp Gly Asp Glu Asn Pro Tyr Gln Leu His Arg Glu 
    450                 455                 460                 

Leu Gly Lys Trp Met Thr Asp His Val Thr Val Val Arg Tyr Asn Asp 
465                 470                 475                 480 

Lys Leu Lys Glu Thr Asp Ala Lys Ile Gln Glu Leu Gln Glu Arg Trp 
                485                 490                 495     

Lys Arg Ile Lys Met Ser Asp Thr Ser Arg Trp Glu Asn Gln Val Ala 
            500                 505                 510         

Gln Phe Thr Arg His Leu Lys Asn Met Leu Ile Met Ala Arg Ala Ile 
        515                 520                 525             

Thr Ile Gly Ala Leu Met Arg Asn Glu Ser Arg Gly Ala His Tyr Lys 
    530                 535                 540                 

Pro Glu Phe Pro Glu Arg Asp Asp Glu Asn Phe Leu Lys Thr Thr Ile 
545                 550                 555                 560 

Ala Glu Tyr Thr Pro Asp Gly Pro Lys Ile Ser Tyr Glu Asp Val Asp 
                565                 570                 575     

Val Ser Leu Ile Lys Pro Arg Lys Arg Asn Tyr Ala Val Ser Lys Glu 
            580                 585                 590         

Ala Thr Lys Glu 
        595     

<210>   1134
<211>   596
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1123

<400>   1134
Met Leu Thr Arg Ala Trp Glu Gly Ile Asp Val Ala Asn Thr Ser Ile 
                5                   10                  15      

Ile Val Val Gly Gly Gly Leu Ala Gly Leu Met Thr Thr Ile Lys Val 
            20                  25                  30          

Ala Glu Ala Gly Val Pro Val Lys Leu Phe Ser Leu Val Pro Val Lys 
        35                  40                  45              

Arg Ser His Ser Val Cys Ala Gln Gly Gly Ile Asn Gly Ala Val Asn 
    50                  55                  60                  

Thr Lys Gly Glu Gly Asp Ser Pro Trp Glu His Phe Asp Asp Thr Ile 
65                  70                  75                  80  

Tyr Gly Gly Asp Phe Leu Ala Asn Gln Pro Pro Val Leu Gly Met Cys 
                85                  90                  95      

Glu Ala Ala Pro Ala Ile Ile Tyr Leu Met Asp Arg Met Gly Val Met 
            100                 105                 110         

Phe Asn Arg Thr Pro Glu Gly Leu Leu Asp Phe Arg Arg Phe Gly Gly 
        115                 120                 125             

Thr Lys His His Arg Thr Ala Phe Ala Gly Ala Ser Thr Gly Gln Gln 
    130                 135                 140                 

Leu Leu Tyr Ala Leu Asp Glu Gln Val Arg Arg Tyr Glu Val Ala Gly 
145                 150                 155                 160 

Leu Val Glu Lys Tyr Glu Gly Trp Asp Phe Leu Gly Ala Val Ile Asp 
                165                 170                 175     

Asp Glu Gln Ile Cys Arg Gly Ile Val Ala Gln Asp Leu Arg Ser Met 
            180                 185                 190         

Glu Ile His Tyr Phe Arg Ala Asp Ala Val Val Met Cys Thr Gly Gly 
        195                 200                 205             

Asn Gly Leu Ile Phe Gly Lys Ser Thr Asn Ser Met Ile Asn Thr Gly 
    210                 215                 220                 

Ser Ala Ala Ser Glu Leu Tyr Gln Gln Gly Val Lys Tyr Ala Asn Pro 
225                 230                 235                 240 

Glu Met Ile Gln Val His Pro Thr Ala Ile Pro Gly Asp Asp Lys Leu 
                245                 250                 255     

Arg Leu Met Ser Glu Ser Ala Arg Gly Glu Gly Gly Arg Val Trp Thr 
            260                 265                 270         

Tyr Lys Asp Gly Lys Pro Trp Tyr Phe Leu Glu Glu Trp Tyr Pro Glu 
        275                 280                 285             

Tyr Gly Asn Leu Val Pro Arg Asp Ile Ala Thr Arg Ala Ile His Lys 
    290                 295                 300                 

Val Cys Val Glu Met Gly Leu Gly Val Asp Gly Gln Asn Met Val Tyr 
305                 310                 315                 320 

Leu Asp Leu Thr His Ile Pro Ala Asp Val Leu Asp Arg Lys Leu Gly 
                325                 330                 335     

Asn Ile Leu Asp Ile Tyr Glu Lys Phe Val Gly Asp Asp Pro Arg Lys 
            340                 345                 350         

Val Pro Met Lys Ile Phe Pro Ala Val His Tyr Ser Met Gly Gly Leu 
        355                 360                 365             

Trp Val Asp Tyr Asp Gln Met Thr Asn Ile Pro Gly Leu Phe Ala Ala 
    370                 375                 380                 

Gly Glu Ala Asp Tyr Gln Tyr His Gly Ala Asn Arg Leu Gly Ala Asn 
385                 390                 395                 400 

Ser Leu Val Ser Cys Ile Tyr Gly Gly Met Ile Ala Gly Pro Asn Ala 
                405                 410                 415     

Val Arg Trp Ala Lys Asn Leu Arg Lys Ser Ala Asp Ser Leu Pro Glu 
            420                 425                 430         

Ser Leu Phe Glu Gln Tyr Arg Arg Lys Tyr Glu Gln Glu Phe Glu Glu 
        435                 440                 445             

Ile Leu Lys Leu Asp Gly Asp Glu Asn Pro Tyr Gln Leu His Arg Glu 
    450                 455                 460                 

Leu Gly Lys Trp Met Thr Asp His Val Thr Val Val Arg Tyr Asn Asp 
465                 470                 475                 480 

Lys Leu Lys Glu Thr Asp Ala Lys Ile Gln Glu Leu Gln Glu Arg Trp 
                485                 490                 495     

Lys Arg Ile Lys Met Ser Asp Thr Ser Arg Trp Glu Asn Gln Val Ala 
            500                 505                 510         

Asn Phe Thr Arg His Leu Lys Asn Met Leu Ile Met Ala Arg Ala Ile 
        515                 520                 525             

Thr Ile Gly Ala Leu Met Arg Asn Glu Ser Arg Gly Ala His Tyr Lys 
    530                 535                 540                 

Pro Glu Phe Pro Glu Arg Asp Asp Glu Asn Phe Leu Lys Thr Thr Ile 
545                 550                 555                 560 

Ala Glu Tyr Thr Pro Asp Gly Pro Lys Ile Ser Tyr Glu Asp Val Asp 
                565                 570                 575     

Val Ser Leu Ile Lys Pro Arg Lys Arg Asn Tyr Ala Val Ser Lys Glu 
            580                 585                 590         

Ala Thr Lys Glu 
        595     

<210>   1135
<211>   1791
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1124

<400>   1135
gtgcttacgc gagcatggga gggaattgac gtggcaaaca cgagcatcat tgtcgtggga       60

ggcggcctgg ccggcctgat gaccaccatc aaggtggcgg aagctggcgt gccggtgaaa      120

ctgttctcct tggtacctgt aaaacgttcc cattccgtgt gtgctcaagg cggcatcaac      180

ggcgccgtga acacgaaggg cgagggcgac tcgccgtggg agcacttcga cgacaccatc      240

tacggcggcg actttctggc caaccagcct ccggttctgg gcatgtgcga ggccgcgccg      300

gccatcatct atttgatgga ccgcatgggc gtcatgttca accgcacgcc ggaaggactg      360

cttgacttcc gccggttcgg cggcacgaag catcaccgca cggcgttcgc gggcgcctcg      420

acagggcagc aactgcttta cgcgttggac gaacaggttc gccgatatga agtggctggc      480

ctcgtcgaga aatacgaggg atgggacttc ctcggcgccg tgatcgacga cgagcagatc      540

tgccgcggca ttgtggcgca ggacctgcgg tccatggaga tccactactt ccgcgccgat      600

gcggtggtca tgtgcaccgg gggcaacgga ctcattttcg gcaagagcac caactcgatg      660

atcaacacgg gttcggcggc atcggatctg taccagcagg gcgtcaagta cgcgaatccg      720

gagatgatcc aggttcaccc gacggccatc cccggggacg acaagctccg cctcatgtct      780

gagtccgcgc gcggcgaggg aggccgcgtc tggacgtaca aggacggcaa gccttggtac      840

ttcctggagg agtggtatcc cgagtacgga aacctggtgc cccgcgacat cgcgacgcgc      900

gccattcaca aggtctgcgt ggagatgggg cttggcgtcg acgggcaaaa catggtctat      960

ctcgacctga cccacatccc ggcggacgtg ctggatcgca agctgggcaa cattctcgat     1020

atctatgaga agttcgtcgg agacgatccg cgcaaggttc cgatgaagat cttccctgct     1080

gtgcactatt cgatgggcgg actgtgggtc gactacgacc agatgaccaa catcccgggc     1140

ctgttcgccg cgggcgaggc cgattatcaa taccacggcg cgaaccgcct cggcgcaaac     1200

tcgctcgtgt cctgcattta cggcggcatg atcgcgggtc cgaacgccgt gcgctgggcg     1260

aagaatctgc gcaagtccgc ggatagcctg cccgagtcgc tgttcgagca gtaccgccgc     1320

aagtacgagc aggaattcga ggaaattctc aagctcgacg gcgacgagaa cccgtaccag     1380

ttgcaccgcg aacttggcaa gtggatgacg gatcacgtca cggtggtgcg ctacaacgac     1440

aagctcaagg agacggacgc caagatccag gagcttcagg agcgctggaa gcggatcaag     1500

atgtcggaca cgtcgcgctg ggagaaccag gtcgcccagt tcacgcgcca cctgaagaat     1560

atgctcatta tggcgcgcgc catcaccatc ggagcgctga tgagaaacga gagccgtggc     1620

gcacactaca agccggagtt cccagagcgc gacgacgaga acttcctgaa gacgaccatc     1680

gccgagtaca cgccggacgg gccgaagatc tcgtacgagg acgtcgacgt ctcgctgatc     1740

aagccgcgta agcgcaacta cgcggtgagc aaggaggcga ccaaggaatg a              1791


<210>   1136
<211>   1791
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1124

<400>   1136
gtgcttacgc gagcatggga gggaattgac gtggcacaaa cgagcatcat tgtcgtggga       60

ggcggcctgg ccggcctgat gaccaccatc aaggtggcgg aagctggcgt gccggtgaaa      120

ctgttctcct tggtacctgt aaaacgttcc cattccgtgt gtgctcaagg cggcatcaac      180

ggcgccgtga acacgaaggg cgagggcgac tcgccgtggg agcacttcga cgacaccatc      240

tacggcggcg actttctggc caaccagcct ccggttctgg gcatgtgcga ggccgcgccg      300

gccatcatct atttgatgga ccgcatgggc gtcatgttca accgcacgcc ggaaggactg      360

cttgacttcc gccggttcgg cggcacgaag catcaccgca cggcgttcgc gggcgcctcg      420

acagggcagc aactgcttta cgcgttggac gaacaggttc gccgatatga agtggctggc      480

ctcgtcgaga aatacgaggg atgggacttc ctcggcgccg tgatcgacga cgagcagatc      540

tgccgcggca ttgtggcgca ggacctgcgg tccatggaga tccactactt ccgcgccgat      600

gcggtggtca tgtgcaccgg gggcaacgga ctcattttcg gcaagagcac caactcgatg      660

atcaacacgg gttcggcggc atcggagctg taccagcagg gcgtcaagta cgcgaatccg      720

gagatgatcc aggttcaccc gacggccatc cccggggacg acaagctccg cctcatgtct      780

gagtccgcgc gcggcgaggg aggccgcgtc tggacgtaca aggacggcaa gccttggtac      840

ttcctggagg agtggtatcc cgagtacgga aacctggtgc cccgcgacat cgcgacgcgc      900

gccattcaca aggtctgcgt ggagatgggg cttggcgtcg acgggcaaaa catggtctat      960

ctcgacctga cccacatccc ggcggacgtg ctggatcgca agctgggcaa cattctcgat     1020

atctatgaga agttcgtcgg agacgatccg cgcaaggttc cgatgaagat cttccctgct     1080

gtgcactatt cgatgggcgg actgtgggtc gactacgacc agatgaccaa catcccgggc     1140

ctgttcgccg cgggcgaggc cgattatcaa taccacggcg cgaaccgcct cggcgcaaac     1200

tcgctcgtgt cctgcattta cggcggcatg atcgcgggtc cgaacgccgt gcgctgggcg     1260

aagaatctgc gcaagtccgc ggatagcctg cccgagtcgc tgttcgagca gtaccgccgc     1320

aagtacgagc aggaattcga ggaaattctc aagctcgacg gcgacgagaa cccgtaccag     1380

ttgcaccgcg aacttggcaa gtggatgacg gatcacgtca cggtggtgcg ctacaacgac     1440

aagctcaagg agacggacgc caagatccag gagcttcagg agcgctggaa gcggatcaag     1500

atgtcggaca cgtcgcgctg ggagaaccag gtcgcccagt tcacgcgcca cctgaagaat     1560

atgctcatta tggcgcgcgc catcaccatc ggagcgctga tgagaaacga gagccgtggc     1620

gcacactaca agccggagtt cccagagcgc gacgacgaga acttcctgaa gacgaccatc     1680

gccgagtaca cgccggacgg gccgaagatc tcgtacgagg acgtcgacgt ctcgctgatc     1740

aagccgcgta agcgcaacta cgcggtgagc aaggaggcga ccaaggaatg a              1791


<210>   1137
<211>   1791
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1124

<400>   1137
gtgcttacgc gagcatggga gggaattgac gtggcaaaca cgagcatcat tgtcgtggga       60

ggcggcctgg ccggcctgat gaccaccatc aaggtggcgg aagctggcgt gccggtgaaa      120

ctgttctcct tggtacctgt aaaacgttcc cattccgtgt gtgctcaagg cggcatcaac      180

ggcgccgtga acacgaaggg cgagggcgac tcgccgtggg agcacttcga cgacaccatc      240

tacggcggcg actttctggc caaccagcct ccggttctgg gcatgtgcga ggccgcgccg      300

gccatcatct atttgatgga ccgcatgggc gtcatgttca accgcacgcc ggaaggactg      360

cttgacttcc gccggttcgg cggcacgaag catcaccgca cggcgttcgc gggcgcctcg      420

acagggcagc aactgcttta cgcgttggac gaacaggttc gccgatatga agtggctggc      480

ctcgtcgaga aatacgaggg atgggacttc ctcggcgccg tgatcgacga cgagcagatc      540

tgccgcggca ttgtggcgca ggacctgcgg tccatggaga tccactactt ccgcgccgat      600

gcggtggtca tgtgcaccgg gggcaacgga ctcattttcg gcaagagcac caactcgatg      660

atcaacacgg gttcggcggc atcggagctg taccagcagg gcgtcaagta cgcgaatccg      720

gagatgatcc aggttcaccc gacggccatc cccggggacg acaagctccg cctcatgtct      780

gagtccgcgc gcggcgaggg aggccgcgtc tggacgtaca aggacggcaa gccttggtac      840

ttcctggagg agtggtatcc cgagtacgga aacctggtgc cccgcgacat cgcgacgcgc      900

gccattcaca aggtctgcgt ggagatgggg cttggcgtcg acgggcaaaa catggtctat      960

ctcgacctga cccacatccc ggcggacgtg ctggatcgca agctgggcaa cattctcgat     1020

atctatgaga agttcgtcgg agacgatccg cgcaaggttc cgatgaagat cttccctgct     1080

gtgcactatt cgatgggcgg actgtgggtc gactacgacc agatgaccaa catcccgggc     1140

ctgttcgccg cgggcgaggc cgattatcaa taccacggcg cgaaccgcct cggcgcaaac     1200

tcgctcgtgt cctgcattta cggcggcatg atcgcgggtc cgaacgccgt gcgctgggcg     1260

aagaatctgc gcaagtccgc ggatagcctg cccgagtcgc tgttcgagca gtaccgccgc     1320

aagtacgagc aggaattcga ggaaattctc aagctcgacg gcgacgagaa cccgtaccag     1380

ttgcaccgcg aacttggcaa gtggatgacg gatcacgtca cggtggtgcg ctacaacgac     1440

aagctcaagg atacggacgc caagatccag gagcttcagg agcgctggaa gcggatcaag     1500

atgtcggaca cgtcgcgctg ggagaaccag gtcgcccagt tcacgcgcca cctgaagaat     1560

atgctcatta tggcgcgcgc catcaccatc ggagcgctga tgagaaacga gagccgtggc     1620

gcacactaca agccggagtt cccagagcgc gacgacgaga acttcctgaa gacgaccatc     1680

gccgagtaca cgccggacgg gccgaagatc tcgtacgagg acgtcgacgt ctcgctgatc     1740

aagccgcgta agcgcaacta cgcggtgagc aaggaggcga ccaaggaatg a              1791


<210>   1138
<211>   1791
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1124

<400>   1138
gtgcttacgc gagcatggga gggaattgac gtggcaaaca cgagcatcat tgtcgtggga       60

ggcggcctgg ccggcctgat gaccaccatc aaggtggcgg aagctggcgt gccggtgaaa      120

ctgttctcct tggtacctgt aaaacgttcc cattccgtgt gtgctcaagg cggcatcaac      180

ggcgccgtga acacgaaggg cgagggcgac tcgccgtggg agcacttcga cgacaccatc      240

tacggcggcg actttctggc caaccagcct ccggttctgg gcatgtgcga ggccgcgccg      300

gccatcatct atttgatgga ccgcatgggc gtcatgttca accgcacgcc ggaaggactg      360

cttgacttcc gccggttcgg cggcacgaag catcaccgca cggcgttcgc gggcgcctcg      420

acagggcagc aactgcttta cgcgttggac gaacaggttc gccgatatga agtggctggc      480

ctcgtcgaga aatacgaggg atgggacttc ctcggcgccg tgatcgacga cgagcagatc      540

tgccgcggca ttgtggcgca ggacctgaaa tccatggaga tccactactt ccgcgccgat      600

gcggtggtca tgtgcaccgg gggcaacgga ctcattttcg gcaagagcac caactcgatg      660

atcaacacgg gttcggcggc atcggagctg taccagcagg gcgtcaagta cgcgaatccg      720

gagatgatcc aggttcaccc gacggccatc cccggggacg acaagctccg cctcatgtct      780

gagtccgcgc gcggcgaggg aggccgcgtc tggacgtaca aggacggcaa gccttggtac      840

ttcctggagg agtggtatcc cgagtacgga aacctggtgc cccgcgacat cgcgacgcgc      900

gccattcaca aggtctgcgt ggagatgggg cttggcgtcg acgggcaaaa catggtctat      960

ctcgacctga cccacatccc ggcggacgtg ctggatcgca agctgggcaa cattctcgat     1020

atctatgaga agttcgtcgg agacgatccg cgcaaggttc cgatgaagat cttccctgct     1080

gtgcactatt cgatgggcgg actgtgggtc gactacgacc agatgaccaa catcccgggc     1140

ctgttcgccg cgggcgaggc cgattatcaa taccacggcg cgaaccgcct cggcgcaaac     1200

tcgctcgtgt cctgcattta cggcggcatg atcgcgggtc cgaacgccgt gcgctgggcg     1260

aagaatctgc gcaagtccgc ggatagcctg cccgagtcgc tgttcgagca gtaccgccgc     1320

aagtacgagc aggaattcga ggaaattctc aagctcgacg gcgacgagaa cccgtaccag     1380

ttgcaccgcg aacttggcaa gtggatgacg gatcacgtca cggtggtgcg ctacaacgac     1440

aagctcaagg agacggacgc caagatccag gagcttcagg agcgctggaa gcggatcaag     1500

atgtcggaca cgtcgcgctg ggagaaccag gtcgcccagt tcacgcgcca cctgaagaat     1560

atgctcatta tggcgcgcgc catcaccatc ggagcgctga tgagaaacga gagccgtggc     1620

gcacactaca agccggagtt cccagagcgc gacgacgaga acttcctgaa gacgaccatc     1680

gccgagtaca cgccggacgg gccgaagatc tcgtacgagg acgtcgacgt ctcgctgatc     1740

aagccgcgta agcgcaacta cgcggtgagc aaggaggcga ccaaggaatg a              1791


<210>   1139
<211>   1791
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1124

<400>   1139
gtgcttacgc gagcatggga gggaattgac gtggcaaaca cgagcatcat tgtcgtggga       60

ggcggcctgg ccggcctgat gaccaccatc aaggtggcgg aagctggcgt gccggtgaaa      120

ctgttctcct tggtacctgt aaaacgttcc cattccgtgt gtgctcaagg cggcatcaac      180

ggcgccgtga acacgaaggg cgagggcgac tcgccgtggg agcacttcga cgacaccatc      240

tacggcggcg actttctggc caaccagcct ccggttctgg gcatgtgcga ggccgcgccg      300

gccatcatct atttgatgga ccgcatgggc gtcatgttca accgcacgcc ggaaggactg      360

cttgacttcc gccggttcgg cggcacgaag catcaccgca cggcgttcgc gggcgcctcg      420

acagggcagc aactgcttta cgcgttggac gaacaggttc gccgatatga agtggctggc      480

ctcgtcgaga aatacgaggg atgggacttc ctcggcgccg tgatcgacga cgagcagatc      540

tgccgcggca ttgtggcgca ggacctgcgg tccatggaga tccactactt ccgcgccgat      600

gcggtggtca tgtgcaccgg gggcaacgga ctcattttcg gcaagagcac caactcgatg      660

atcaacacgg gttcggcggc atcggagctg taccagcagg gcgtcaagta cgcgaatccg      720

gagatgatcc aggttcaccc gacggccatc cccggggacg acaagctccg cctcatgtct      780

gagtccgcgc gcggcgaggg aggccgcgtc tggacgtaca aggacggcaa gccttggtac      840

ttcctggagg agtggtatcc cgagtacgga aacctggtgc cccgcgacat cgcgacgcgc      900

gccattcaca aggtctgcgt ggagatgggg cttggcgtcg acgggcaaaa catggtctat      960

ctcgacctga cccacatccc ggcggacgtg ctggatcgca agctgggcaa cattctcgat     1020

atctatgaga agttcgtcgg agacgatccg cgcaaggttc cgatgaagat cttccctgct     1080

gtgcactatt cgatgggcgg actgtgggtc gactacgacc agatgaccaa catcccgggc     1140

ctgttcgccg cgggcgaggc cgattatcaa taccacggcg cgaaccgcct cggcgcaaac     1200

tcgctcgtgt cctgcattta cggcggcatg atcgcgggtc cgaacgccgt gcgctgggcg     1260

aagaatctgc gcaagtccgc ggatagcctg cccgagtcgc tgttcgagca gtaccgccgc     1320

aagtacgagc aggaattcga ggaaattctc aagctcgacg gcgacgagaa cccgtaccag     1380

ttgcaccgcg aacttggcaa gtggatgacg gatcacgtca cggtggtgcg ctacaacgac     1440

aagctcaagg agacggacgc caagatccag gagcttcagg agcgctggaa gcggatcaag     1500

atgtcggaca cgtcgcgctg ggagaaccag gtcgccaatt tcacgcgcca cctgaagaat     1560

atgctcatta tggcgcgcgc catcaccatc ggagcgctga tgagaaacga gagccgtggc     1620

gcacactaca agccggagtt cccagagcgc gacgacgaga acttcctgaa gacgaccatc     1680

gccgagtaca cgccggacgg gccgaagatc tcgtacgagg acgtcgacgt ctcgctgatc     1740

aagccgcgta agcgcaacta cgcggtgagc aaggaggcga ccaaggaatg a              1791


<210>   1140
<211>   262
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1140
Met Ser Thr Thr Ala Glu Ala Val Gln Gln Ala Gln Ala Asp Ser Gly 
                5                   10                  15      

Arg Lys Val His Leu Ile Ile Glu Arg Gln Asp Thr Pro Asp Ser Glu 
            20                  25                  30          

Pro Tyr Trp Glu Glu Phe Glu Val Pro Tyr Arg Pro Gly Met Asn Val 
        35                  40                  45              

Ile Ala Cys Leu Met Glu Ile Gln Arg Asn Pro Val Asn Lys Lys Gly 
    50                  55                  60                  

Glu Pro Val Ala Pro Val Thr Trp Glu Met Asn Cys Leu Glu Glu Val 
65                  70                  75                  80  

Cys Gly Ala Cys Thr Met Val Ile Asn Asn Lys Pro Arg Gln Ala Cys 
                85                  90                  95      

Ser Ala Leu Val Asp Lys Leu Gln Gln Pro Ile Arg Ile Arg Pro Met 
            100                 105                 110         

Arg Thr Phe Pro Val Val Arg Asp Leu Val Val Asp Arg Ser Arg Met 
        115                 120                 125             

Phe Glu Ala Leu Lys Arg Ile Lys Ala Trp Ile Pro Ile Asp Gly Thr 
    130                 135                 140                 

His Asp Leu Gly Pro Gly Pro Arg Met Ser Ser Glu Glu Gln Gln Ile 
145                 150                 155                 160 

Ala Tyr Glu Leu Ser Arg Cys Phe Thr Cys Gly Ala Cys Val Glu Ala 
                165                 170                 175     

Cys Pro Asn Val Asn Asp Lys Thr Ser Phe Ile Gly Pro Phe Ala Ile 
            180                 185                 190         

Ser Gln Ala Arg Leu Phe Asn Met His Pro Thr Gly Lys Met Asn Lys 
        195                 200                 205             

Glu Glu Arg Leu Gln Ala Leu Met Gly Glu Gly Gly Ile Phe Glu Cys 
    210                 215                 220                 

Gly Asn Ala Gln Asn Cys Val Glu Val Cys Pro Lys Gly Ile Pro Leu 
225                 230                 235                 240 

Thr Thr Ser Ile Ala Val Met Asn Arg Glu Val Thr Tyr Arg Ala Ile 
                245                 250                 255     

Gly Ala Trp Leu Arg Lys 
            260         

<210>   1141
<211>   789
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1141
atgagcacaa cagcggaggc cgtgcagcag gcgcaggcgg attcgggtcg caaggtgcat       60

ctcatcatcg agcggcagga cacgccggat tcggagccgt actgggagga atttgaggtt      120

ccgtatcgcc caggcatgaa cgtgattgcc tgtctgatgg agatccagcg caatcccgtg      180

aacaagaagg gcgagccggt cgcaccggtc acctgggaga tgaactgcct ggaagaggtc      240

tgcggcgcct gcaccatggt gatcaacaac aagccccgcc aggcgtgttc ggcgctcgtg      300

gataagttgc agcagcccat ccggattcgg ccgatgcgca cgttcccggt ggttcgcgac      360

cttgtcgtcg accgcagccg gatgttcgag gcgctcaagc gcatcaaggc ttggattccg      420

atcgacggca cacacgatct cggcccaggt ccgcgcatgt cgagcgagga gcagcagatt      480

gcgtacgagc tgtctcgctg cttcacgtgc ggcgcctgtg tcgaagcatg tcccaatgtg      540

aacgacaaga cgtcgttcat cggtccgttc gccatttctc aggcgcgcct gttcaacatg      600

cacccgacgg gcaagatgaa caaagaggag cgcctgcagg cgctgatggg cgaaggcggc      660

atcttcgagt gcggcaatgc gcagaactgc gtggaggtat gtccgaaggg cattccgctc      720

acgacgtcca tcgctgtgat gaaccgagag gtgacctacc gcgcgattgg cgcgtggctg      780

cgcaagtag                                                              789


<210>   1142
<211>   257
<212>   PRT
<213>   Paenibacillus macerans

<400>   1142
Met Ala Glu Thr Glu Ala Ala Val Lys Gln Lys Ser Gly Lys Lys Val 
                5                   10                  15      

Lys Phe Ile Ile Thr Arg Gln Asp Asp Pro Asn Ser Gln Pro Tyr Thr 
            20                  25                  30          

Glu Glu Phe Glu Leu Asp Tyr Arg Pro Asn Met Asn Val Ile Ser Ala 
        35                  40                  45              

Leu Met Glu Ile Gln Arg Asn Pro Val Asn Gln Lys Gly Glu His Thr 
    50                  55                  60                  

Ala Pro Val Cys Trp Glu Ser Asn Cys Leu Glu Glu Val Cys Gly Ala 
65                  70                  75                  80  

Cys Ser Met Val Ile Asn Gly Lys Pro Arg Gln Ala Cys Ala Ala Leu 
                85                  90                  95      

Ile Asp Gln Leu Glu Gln Pro Val Arg Ile Glu Pro Met Arg Thr Phe 
            100                 105                 110         

Pro Val Val Arg Asp Leu Val Ile Asp Arg Ser Arg Met Phe Asn Ala 
        115                 120                 125             

Leu Lys Arg Val Lys Ala Trp Ile Pro Ile Asp Gly Thr Tyr Asp Leu 
    130                 135                 140                 

Gly Pro Gly Pro Arg Met Pro Glu Lys Lys Arg Gln Trp Ala Tyr Glu 
145                 150                 155                 160 

Leu Ser Lys Cys Met Thr Cys Gly Val Cys Leu Glu Ala Cys Pro Asn 
                165                 170                 175     

Val Asn Glu Lys Thr Asp Phe Ile Gly Pro Ala Ala Ile Ser Gln Val 
            180                 185                 190         

Arg Leu Phe Asn Ala His Pro Thr Gly Ala Met Asn Ala Asp Glu Arg 
        195                 200                 205             

Leu Asp Ala Leu Met Glu Asp Gly Gly Ile Glu Gly Cys Gly Asn Ser 
    210                 215                 220                 

Gln Asn Cys Val Arg Ala Cys Pro Lys Gly Ile Pro Leu Thr Thr Ser 
225                 230                 235                 240 

Ile Ala Glu Met Asn Arg Asp Thr Thr Lys Arg Met Phe Lys Arg Trp 
                245                 250                 255     

Leu 
    

<210>   1143
<211>   236
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1143
Lys Thr Val Arg Leu Ile Ile Thr Arg Gln Asp Arg Pro Asp Ser Ala 
                5                   10                  15      

Pro Tyr Glu Glu Glu Phe Val Ile Pro Tyr Arg Pro Asn Met Asn Val 
            20                  25                  30          

Ile Ser Ala Leu Met Glu Ile Arg Arg Asn Pro Val Asn Ala Lys Gly 
        35                  40                  45              

Glu Lys Thr Thr Pro Val Ala Trp Glu Met Asn Cys Leu Glu Glu Val 
    50                  55                  60                  

Cys Gly Ala Cys Ser Met Val Ile Asn Gly Lys Pro Arg Gln Ala Cys 
65                  70                  75                  80  

Ala Ala Leu Ile Asp Lys Leu Glu Gln Pro Ile Arg Leu Glu Pro Met 
                85                  90                  95      

Arg Thr Phe Pro Val Ile Arg Asp Leu Val Ile Asp Arg Ser Arg Met 
            100                 105                 110         

Phe Asp Ala Leu Lys Arg Val Lys Ala Trp Ile Pro Ile Asp Gly Thr 
        115                 120                 125             

Tyr Asp Leu Gly Pro Gly Pro Arg Met Pro Glu Arg Lys Arg Gln Trp 
    130                 135                 140                 

Ala Tyr Glu Leu Ser Lys Cys Met Thr Cys Gly Val Cys Leu Glu Ala 
145                 150                 155                 160 

Cys Pro Asn Val Asn Ser Lys Ser Asn Phe Ile Gly Pro Ala Pro Leu 
                165                 170                 175     

Ser Gln Val Arg Leu Phe Asn Ala His Pro Thr Gly Ala Met His Lys 
            180                 185                 190         

Ala Glu Arg Leu Arg Ala Ile Met Gly Asp Gly Gly Leu Ala Asn Cys 
        195                 200                 205             

Gly Asn Ser Gln Asn Cys Val Gln Ser Cys Pro Lys Gly Ile Pro Leu 
    210                 215                 220                 

Thr Thr Ser Ile Ala Ala Leu Asn Arg Glu Thr Thr 
225                 230                 235     

<210>   1144
<211>   239
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1144
Lys Thr Ile Lys Phe Ile Ile Thr Arg Gln Asp Thr Ser Asp Ser Asn 
                5                   10                  15      

Pro Tyr Gln Glu Glu Phe Glu Ile Pro Tyr Arg Pro Asn Met Asn Val 
            20                  25                  30          

Ile Ser Ala Leu Met Glu Ile Arg Arg Asn Pro Val Asn Ala Lys Gly 
        35                  40                  45              

Glu Lys Thr Ser Pro Ile Ala Trp Asp Met Asn Cys Leu Glu Glu Val 
    50                  55                  60                  

Cys Gly Ala Cys Ser Met Val Ile Asn Gly Lys Pro Arg Gln Ser Cys 
65                  70                  75                  80  

Thr Ala Leu Ile Asp Gln Leu Glu Gln Pro Ile Arg Leu Glu Pro Met 
                85                  90                  95      

Lys Thr Phe Pro Val Val Arg Asp Leu Gln Val Asp Arg Ser Arg Met 
            100                 105                 110         

Phe Asp Ser Leu Lys Lys Val Lys Ala Trp Val Pro Ile Asp Gly Thr 
        115                 120                 125             

Tyr Asp Leu Gly Pro Gly Pro Arg Met Pro Glu Arg Arg Arg Gln Trp 
    130                 135                 140                 

Ala Tyr Glu Leu Ser Lys Cys Met Thr Cys Gly Val Cys Leu Glu Ala 
145                 150                 155                 160 

Cys Pro Asn Val Asn Asp Lys Thr Asn Phe Met Gly Pro Ala Pro Leu 
                165                 170                 175     

Ser Gln Val Arg Leu Phe Asn Thr His Pro Thr Gly Ala Met Asn Lys 
            180                 185                 190         

Ser Glu Arg Leu Glu Ala Ile Met Gly Asp Gly Gly Leu Ala Glu Cys 
        195                 200                 205             

Gly Asn Ser Gln Asn Cys Val Gln Ser Cys Pro Lys Gly Ile Pro Leu 
    210                 215                 220                 

Thr Thr Ser Ile Ala Ala Leu Asn Arg Asp Thr Thr Val Gln Ala 
225                 230                 235                 

<210>   1145
<211>   237
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1145
Val Arg Phe Ile Ile Thr Arg Gln Asp Asp Pro Asp Ser Ser Pro Tyr 
                5                   10                  15      

Glu Glu Glu Phe Gln Val Pro Tyr Arg Gln Asn Met Asn Val Ile Ser 
            20                  25                  30          

Ala Leu Met Glu Ile Arg Arg Asn Pro Val Asn Ser Lys Gly Glu Thr 
        35                  40                  45              

Ser Thr Pro Val Ala Trp Glu Met Asn Cys Leu Glu Glu Val Cys Gly 
    50                  55                  60                  

Ala Cys Ser Met Val Ile Asn Gly Lys Pro Arg Gln Ser Cys Thr Ala 
65                  70                  75                  80  

Leu Val Asp Gln Leu Glu Gln Pro Ile Arg Leu Glu Pro Met Lys Thr 
                85                  90                  95      

Phe Pro Val Val Arg Asp Leu Val Ile Asp Arg Ser Arg Met Phe Asp 
            100                 105                 110         

Ser Leu Lys Lys Val Lys Ala Trp Ile Pro Ile Asp Gly Thr Tyr Asp 
        115                 120                 125             

Leu Gly Pro Gly Pro Arg Met Ala Glu Ser Lys Arg Gln Trp Ala Tyr 
    130                 135                 140                 

Glu Leu Ser Lys Cys Met Thr Cys Gly Val Cys Leu Glu Ala Cys Pro 
145                 150                 155                 160 

Asn Val Asn Ser Lys Ser Glu Phe Ile Gly Pro Ala Pro Leu Ser Gln 
                165                 170                 175     

Val Arg Leu Phe Asn Ala His Pro Thr Gly Glu Met Asn Lys Glu Glu 
            180                 185                 190         

Arg Leu Gln Ala Ile Met Gly Asp Gly Gly Leu Ala Asn Cys Gly Asn 
        195                 200                 205             

Ser Gln Asn Cys Val Gln Ser Cys Pro Lys Gly Ile Pro Leu Thr Thr 
    210                 215                 220                 

Ser Ile Ala Ala Leu Asn Arg Ser Ala Thr Leu Gln Ser 
225                 230                 235         

<210>   1146
<211>   236
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   1146
Lys Thr Val Thr Phe Ile Ile Gln Arg Gln Asp Asn Pro Glu Ser Glu 
                5                   10                  15      

Pro Tyr Asp Glu Thr Phe Glu Val Pro Tyr Arg Pro Asn Met Asn Val 
            20                  25                  30          

Ile Ser Ala Leu Met Glu Ile Arg Arg Asn Pro Val Asn Ala Lys Gly 
        35                  40                  45              

Glu Lys Thr Thr Pro Val Val Trp Glu Met Asn Cys Leu Glu Glu Val 
    50                  55                  60                  

Cys Gly Ala Cys Ser Met Val Ile Asn Gly Lys Pro Arg Gln Ala Cys 
65                  70                  75                  80  

Ser Ala Leu Val Asp Lys Leu Gln Gln Pro Ile Arg Leu Ala Pro Met 
                85                  90                  95      

Arg Thr Phe Pro Val Val Arg Asp Leu Gln Ile Asp Arg Gly Arg Met 
            100                 105                 110         

Phe Asp Ser Leu Lys Lys Val Lys Ala Trp Ile Pro Ile Asp Gly Thr 
        115                 120                 125             

Tyr Asp Leu Gly Glu Gly Pro Arg Met Pro Glu Lys Lys Arg Gln Trp 
    130                 135                 140                 

Ala Tyr Glu Leu Ala Lys Cys Met Thr Cys Gly Val Cys Leu Glu Ala 
145                 150                 155                 160 

Cys Pro Asn Val Asn Ser Arg Ser Asn Phe Ile Gly Pro Ala Pro Leu 
                165                 170                 175     

Ser Gln Val Arg Leu Phe Asn Ala His Pro Thr Gly His Met Asn Arg 
            180                 185                 190         

Asp Glu Arg Leu Glu Ala Ile Met Gly Asp Gly Gly Leu Ala Asn Cys 
        195                 200                 205             

Gly Asn Ser Gln Asn Cys Val Gln Ala Cys Pro Lys Gly Ile Pro Leu 
    210                 215                 220                 

Thr Thr Ser Ile Ala Ala Leu Asn Arg Glu Thr Thr 
225                 230                 235     

<210>   1147
<211>   262
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1140

<400>   1147
Met Ser Thr Thr Ala Glu Ala Val Gln Gln Ala Gln Ala Asp Ser Gly 
                5                   10                  15      

Arg Lys Val His Leu Ile Ile Glu Arg Gln Asp Thr Pro Asp Ser Glu 
            20                  25                  30          

Pro Tyr Trp Glu Glu Phe Glu Val Pro Tyr Arg Pro Gly Met Asn Val 
        35                  40                  45              

Ile Ala Cys Leu Met Glu Ile Gln Arg Asn Pro Val Asn Lys Lys Gly 
    50                  55                  60                  

Glu Pro Val Ala Pro Val Thr Trp Glu Met Asn Cys Leu Glu Glu Val 
65                  70                  75                  80  

Cys Gly Ala Cys Thr Met Val Ile Asn Asn Lys Pro Arg Gln Ala Cys 
                85                  90                  95      

Ser Ala Leu Val Asp Lys Leu Gln Gln Pro Ile Arg Ile Arg Pro Met 
            100                 105                 110         

Arg Thr Phe Pro Val Val Arg Asp Leu Val Val Asp Arg Ser Arg Met 
        115                 120                 125             

Phe Glu Ala Leu Lys Arg Ile Lys Ala Trp Ile Pro Ile Asp Gly Thr 
    130                 135                 140                 

His Asp Leu Gly Pro Gly Pro Arg Met Ser Ser Glu Glu Gln Gln Ile 
145                 150                 155                 160 

Ala Tyr Glu Leu Ser Arg Cys Phe Thr Cys Gly Ala Cys Val Glu Ala 
                165                 170                 175     

Cys Pro Asn Val Asn Asp Lys Thr Ser Phe Ile Gly Pro Phe Ala Ile 
            180                 185                 190         

Ser Gln Ala Arg Leu Phe Asn Met His Pro Thr Gly Arg Met Asn Lys 
        195                 200                 205             

Glu Glu Arg Leu Gln Ala Leu Met Gly Glu Gly Gly Ile Phe Glu Cys 
    210                 215                 220                 

Gly Asn Ala Gln Asn Cys Val Glu Val Cys Pro Lys Gly Ile Pro Leu 
225                 230                 235                 240 

Thr Thr Ser Ile Ala Val Met Asn Arg Glu Val Thr Tyr Arg Ala Ile 
                245                 250                 255     

Gly Ala Trp Leu Arg Lys 
            260         

<210>   1148
<211>   262
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1140

<400>   1148
Met Ser Thr Thr Ala Glu Ala Val Gln Gln Ala Gln Ala Asp Ser Gly 
                5                   10                  15      

Arg Lys Val His Leu Ile Ile Glu Arg Gln Asp Thr Pro Asp Ser Glu 
            20                  25                  30          

Pro Tyr Trp Glu Glu Phe Glu Val Pro Tyr Arg Pro Gly Met Asn Val 
        35                  40                  45              

Ile Ala Cys Leu Met Glu Ile Gln Arg Asn Pro Val Asn Lys Lys Gly 
    50                  55                  60                  

Glu Pro Val Ala Pro Val Thr Trp Glu Met Asn Cys Leu Glu Glu Val 
65                  70                  75                  80  

Cys Gly Ala Cys Thr Met Val Ile Asn Asn Lys Pro Arg Gln Ala Cys 
                85                  90                  95      

Ser Ala Leu Val Asp Lys Leu Gln Gln Pro Ile Arg Ile Arg Pro Met 
            100                 105                 110         

Arg Thr Phe Pro Val Val Arg Asp Leu Val Val Asp Arg Ser Arg Met 
        115                 120                 125             

Phe Glu Ala Leu Lys Arg Ile Lys Ala Trp Ile Pro Ile Asp Gly Thr 
    130                 135                 140                 

His Asp Leu Gly Pro Gly Pro Arg Met Ser Ser Glu Glu Gln Gln Leu 
145                 150                 155                 160 

Ala Tyr Glu Leu Ser Arg Cys Phe Thr Cys Gly Ala Cys Val Glu Ala 
                165                 170                 175     

Cys Pro Asn Val Asn Asp Lys Thr Ser Phe Ile Gly Pro Phe Ala Ile 
            180                 185                 190         

Ser Gln Ala Arg Leu Phe Asn Met His Pro Thr Gly Lys Met Asn Lys 
        195                 200                 205             

Glu Glu Arg Leu Gln Ala Leu Met Gly Glu Gly Gly Ile Phe Glu Cys 
    210                 215                 220                 

Gly Asn Ala Gln Asn Cys Val Glu Val Cys Pro Lys Gly Ile Pro Leu 
225                 230                 235                 240 

Thr Thr Ser Ile Ala Val Met Asn Arg Glu Val Thr Tyr Arg Ala Ile 
                245                 250                 255     

Gly Ala Trp Leu Arg Lys 
            260         

<210>   1149
<211>   262
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1140

<400>   1149
Met Ser Thr Thr Ala Glu Ala Val Gln Gln Ala Gln Ala Asp Ser Gly 
                5                   10                  15      

Arg Lys Val His Leu Ile Ile Glu Arg Gln Asp Thr Pro Asp Ser Glu 
            20                  25                  30          

Pro Tyr Trp Glu Glu Phe Glu Val Pro Tyr Arg Pro Gly Met Asn Val 
        35                  40                  45              

Ile Ala Cys Leu Met Glu Ile Gln Arg Asn Pro Val Asn Lys Lys Gly 
    50                  55                  60                  

Glu Pro Val Ala Pro Val Thr Trp Glu Met Asn Cys Leu Glu Glu Val 
65                  70                  75                  80  

Cys Gly Ala Cys Thr Met Val Ile Asn Asn Lys Pro Arg Gln Ala Cys 
                85                  90                  95      

Ser Ala Leu Val Asp Lys Leu Gln Gln Pro Ile Arg Ile Arg Pro Met 
            100                 105                 110         

Arg Thr Phe Pro Val Val Arg Asp Leu Val Val Asp Arg Ser Arg Met 
        115                 120                 125             

Phe Glu Ala Leu Lys Arg Ile Lys Ala Trp Ile Pro Ile Asp Gly Thr 
    130                 135                 140                 

His Asp Leu Gly Pro Gly Pro Arg Met Ser Ser Glu Glu Gln Gln Ile 
145                 150                 155                 160 

Ala Tyr Glu Leu Ser Arg Cys Phe Thr Cys Gly Ala Cys Val Glu Ala 
                165                 170                 175     

Cys Pro Asn Val Asn Asp Lys Thr Ser Phe Ile Gly Pro Phe Ala Ile 
            180                 185                 190         

Ser Gln Ala Arg Leu Phe Asn Met His Pro Thr Gly Lys Met Asn Lys 
        195                 200                 205             

Glu Glu Arg Leu Gln Ala Leu Met Gly Glu Gly Gly Ile Phe Glu Cys 
    210                 215                 220                 

Gly Asn Ala Gln Asn Cys Val Glu Val Cys Pro Lys Gly Ile Pro Leu 
225                 230                 235                 240 

Thr Thr Ser Ile Ala Val Met Asn Arg Glu Val Thr Tyr Arg Ala Leu 
                245                 250                 255     

Gly Ala Trp Leu Arg Lys 
            260         

<210>   1150
<211>   262
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1140

<400>   1150
Met Ser Thr Thr Ala Glu Ala Val Gln Gln Ala Gln Ala Asp Ser Gly 
                5                   10                  15      

Arg Lys Val His Leu Ile Ile Glu Arg Gln Asp Thr Pro Asp Ser Glu 
            20                  25                  30          

Pro Tyr Trp Glu Glu Phe Glu Val Pro Tyr Arg Pro Gly Met Asn Val 
        35                  40                  45              

Ile Ala Cys Leu Met Glu Ile Gln Arg Asn Pro Val Asn Lys Lys Gly 
    50                  55                  60                  

Glu Pro Val Ala Pro Val Thr Trp Glu Met Asn Cys Leu Glu Glu Val 
65                  70                  75                  80  

Cys Gly Ala Cys Thr Met Val Ile Asn Asn Lys Pro Arg Gln Ala Cys 
                85                  90                  95      

Ser Ala Leu Val Asp Lys Leu Gln Gln Pro Ile Arg Ile Arg Pro Met 
            100                 105                 110         

Arg Thr Phe Pro Val Val Arg Asp Leu Val Val Asp Arg Ser Arg Met 
        115                 120                 125             

Phe Glu Ala Leu Lys Arg Ile Lys Ala Trp Ile Pro Ile Asp Gly Thr 
    130                 135                 140                 

His Asp Leu Gly Pro Gly Pro Arg Met Ser Ser Glu Glu Gln Gln Ile 
145                 150                 155                 160 

Ala Tyr Glu Leu Ser Arg Cys Phe Thr Cys Gly Ala Cys Val Glu Ala 
                165                 170                 175     

Cys Pro Asn Val Asn Asp Lys Thr Ser Phe Ile Gly Pro Phe Ala Ile 
            180                 185                 190         

Ser Gln Ala Arg Leu Phe Asn Met His Pro Thr Gly Lys Met Asn Lys 
        195                 200                 205             

Glu Glu Arg Leu Asn Ala Leu Met Gly Glu Gly Gly Ile Phe Glu Cys 
    210                 215                 220                 

Gly Asn Ala Gln Asn Cys Val Glu Val Cys Pro Lys Gly Ile Pro Leu 
225                 230                 235                 240 

Thr Thr Ser Ile Ala Val Met Asn Arg Glu Val Thr Tyr Arg Ala Ile 
                245                 250                 255     

Gly Ala Trp Leu Arg Lys 
            260         

<210>   1151
<211>   262
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1140

<400>   1151
Met Ser Thr Thr Ala Glu Ala Val Gln Gln Ala Gln Ala Asp Ser Gly 
                5                   10                  15      

Arg Lys Val His Leu Ile Ile Glu Arg Gln Asp Thr Pro Asp Ser Glu 
            20                  25                  30          

Pro Tyr Trp Glu Asp Phe Glu Val Pro Tyr Arg Pro Gly Met Asn Val 
        35                  40                  45              

Ile Ala Cys Leu Met Glu Ile Gln Arg Asn Pro Val Asn Lys Lys Gly 
    50                  55                  60                  

Glu Pro Val Ala Pro Val Thr Trp Glu Met Asn Cys Leu Glu Glu Val 
65                  70                  75                  80  

Cys Gly Ala Cys Thr Met Val Ile Asn Asn Lys Pro Arg Gln Ala Cys 
                85                  90                  95      

Ser Ala Leu Val Asp Lys Leu Gln Gln Pro Ile Arg Ile Arg Pro Met 
            100                 105                 110         

Arg Thr Phe Pro Val Val Arg Asp Leu Val Val Asp Arg Ser Arg Met 
        115                 120                 125             

Phe Glu Ala Leu Lys Arg Ile Lys Ala Trp Ile Pro Ile Asp Gly Thr 
    130                 135                 140                 

His Asp Leu Gly Pro Gly Pro Arg Met Ser Ser Glu Glu Gln Gln Ile 
145                 150                 155                 160 

Ala Tyr Glu Leu Ser Arg Cys Phe Thr Cys Gly Ala Cys Val Glu Ala 
                165                 170                 175     

Cys Pro Asn Val Asn Asp Lys Thr Ser Phe Ile Gly Pro Phe Ala Ile 
            180                 185                 190         

Ser Gln Ala Arg Leu Phe Asn Met His Pro Thr Gly Lys Met Asn Lys 
        195                 200                 205             

Glu Glu Arg Leu Gln Ala Leu Met Gly Glu Gly Gly Ile Phe Glu Cys 
    210                 215                 220                 

Gly Asn Ala Gln Asn Cys Val Glu Val Cys Pro Lys Gly Ile Pro Leu 
225                 230                 235                 240 

Thr Thr Ser Ile Ala Val Met Asn Arg Glu Val Thr Tyr Arg Ala Ile 
                245                 250                 255     

Gly Ala Trp Leu Arg Lys 
            260         

<210>   1152
<211>   789
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1141

<400>   1152
atgagcacaa cagcggaggc cgtgcagcag gcgcaggcgg attcgggtcg caaggtgcat       60

ctcatcatcg agcggcagga cacgccggat tcggagccgt actgggagga atttgaggtt      120

ccgtatcgcc caggcatgaa cgtgattgcc tgtctgatgg agatccagcg caatcccgtg      180

aacaagaagg gcgagccggt cgcaccggtc acctgggaga tgaactgcct ggaagaggtc      240

tgcggcgcct gcaccatggt gatcaacaac aagccccgcc aggcgtgttc ggcgctcgtg      300

gataagttgc agcagcccat ccggattcgg ccgatgcgca cgttcccggt ggttcgcgac      360

cttgtcgtcg accgcagccg gatgttcgag gcgctcaagc gcatcaaggc ttggattccg      420

atcgacggca cacacgatct cggcccaggt ccgcgcatgt cgagcgagga gcagcagatt      480

gcgtacgagc tgtctcgctg cttcacgtgc ggcgcctgtg tcgaagcatg tcccaatgtg      540

aacgacaaga cgtcgttcat cggtccgttc gccatttctc aggcgcgcct gttcaacatg      600

cacccgacgg gccgtatgaa caaagaggag cgcctgcagg cgctgatggg cgaaggcggc      660

atcttcgagt gcggcaatgc gcagaactgc gtggaggtat gtccgaaggg cattccgctc      720

acgacgtcca tcgctgtgat gaaccgagag gtgacctacc gcgcgattgg cgcgtggctg      780

cgcaagtag                                                              789


<210>   1153
<211>   789
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1141

<400>   1153
atgagcacaa cagcggaggc cgtgcagcag gcgcaggcgg attcgggtcg caaggtgcat       60

ctcatcatcg agcggcagga cacgccggat tcggagccgt actgggagga atttgaggtt      120

ccgtatcgcc caggcatgaa cgtgattgcc tgtctgatgg agatccagcg caatcccgtg      180

aacaagaagg gcgagccggt cgcaccggtc acctgggaga tgaactgcct ggaagaggtc      240

tgcggcgcct gcaccatggt gatcaacaac aagccccgcc aggcgtgttc ggcgctcgtg      300

gataagttgc agcagcccat ccggattcgg ccgatgcgca cgttcccggt ggttcgcgac      360

cttgtcgtcg accgcagccg gatgttcgag gcgctcaagc gcatcaaggc ttggattccg      420

atcgacggca cacacgatct cggcccaggt ccgcgcatgt cgagcgagga gcagcagtta      480

gcgtacgagc tgtctcgctg cttcacgtgc ggcgcctgtg tcgaagcatg tcccaatgtg      540

aacgacaaga cgtcgttcat cggtccgttc gccatttctc aggcgcgcct gttcaacatg      600

cacccgacgg gcaagatgaa caaagaggag cgcctgcagg cgctgatggg cgaaggcggc      660

atcttcgagt gcggcaatgc gcagaactgc gtggaggtat gtccgaaggg cattccgctc      720

acgacgtcca tcgctgtgat gaaccgagag gtgacctacc gcgcgattgg cgcgtggctg      780

cgcaagtag                                                              789


<210>   1154
<211>   789
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1141

<400>   1154
atgagcacaa cagcggaggc cgtgcagcag gcgcaggcgg attcgggtcg caaggtgcat       60

ctcatcatcg agcggcagga cacgccggat tcggagccgt actgggagga atttgaggtt      120

ccgtatcgcc caggcatgaa cgtgattgcc tgtctgatgg agatccagcg caatcccgtg      180

aacaagaagg gcgagccggt cgcaccggtc acctgggaga tgaactgcct ggaagaggtc      240

tgcggcgcct gcaccatggt gatcaacaac aagccccgcc aggcgtgttc ggcgctcgtg      300

gataagttgc agcagcccat ccggattcgg ccgatgcgca cgttcccggt ggttcgcgac      360

cttgtcgtcg accgcagccg gatgttcgag gcgctcaagc gcatcaaggc ttggattccg      420

atcgacggca cacacgatct cggcccaggt ccgcgcatgt cgagcgagga gcagcagatt      480

gcgtacgagc tgtctcgctg cttcacgtgc ggcgcctgtg tcgaagcatg tcccaatgtg      540

aacgacaaga cgtcgttcat cggtccgttc gccatttctc aggcgcgcct gttcaacatg      600

cacccgacgg gcaagatgaa caaagaggag cgcctgcagg cgctgatggg cgaaggcggc      660

atcttcgagt gcggcaatgc gcagaactgc gtggaggtat gtccgaaggg cattccgctc      720

acgacgtcca tcgctgtgat gaaccgagag gtgacctacc gcgcgttagg cgcgtggctg      780

cgcaagtag                                                              789


<210>   1155
<211>   789
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1141

<400>   1155
atgagcacaa cagcggaggc cgtgcagcag gcgcaggcgg attcgggtcg caaggtgcat       60

ctcatcatcg agcggcagga cacgccggat tcggagccgt actgggagga atttgaggtt      120

ccgtatcgcc caggcatgaa cgtgattgcc tgtctgatgg agatccagcg caatcccgtg      180

aacaagaagg gcgagccggt cgcaccggtc acctgggaga tgaactgcct ggaagaggtc      240

tgcggcgcct gcaccatggt gatcaacaac aagccccgcc aggcgtgttc ggcgctcgtg      300

gataagttgc agcagcccat ccggattcgg ccgatgcgca cgttcccggt ggttcgcgac      360

cttgtcgtcg accgcagccg gatgttcgag gcgctcaagc gcatcaaggc ttggattccg      420

atcgacggca cacacgatct cggcccaggt ccgcgcatgt cgagcgagga gcagcagatt      480

gcgtacgagc tgtctcgctg cttcacgtgc ggcgcctgtg tcgaagcatg tcccaatgtg      540

aacgacaaga cgtcgttcat cggtccgttc gccatttctc aggcgcgcct gttcaacatg      600

cacccgacgg gcaagatgaa caaagaggag cgcctgaatg cgctgatggg cgaaggcggc      660

atcttcgagt gcggcaatgc gcagaactgc gtggaggtat gtccgaaggg cattccgctc      720

acgacgtcca tcgctgtgat gaaccgagag gtgacctacc gcgcgattgg cgcgtggctg      780

cgcaagtag                                                              789


<210>   1156
<211>   789
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1141

<400>   1156
atgagcacaa cagcggaggc cgtgcagcag gcgcaggcgg attcgggtcg caaggtgcat       60

ctcatcatcg agcggcagga cacgccggat tcggagccgt actgggagga ttttgaggtt      120

ccgtatcgcc caggcatgaa cgtgattgcc tgtctgatgg agatccagcg caatcccgtg      180

aacaagaagg gcgagccggt cgcaccggtc acctgggaga tgaactgcct ggaagaggtc      240

tgcggcgcct gcaccatggt gatcaacaac aagccccgcc aggcgtgttc ggcgctcgtg      300

gataagttgc agcagcccat ccggattcgg ccgatgcgca cgttcccggt ggttcgcgac      360

cttgtcgtcg accgcagccg gatgttcgag gcgctcaagc gcatcaaggc ttggattccg      420

atcgacggca cacacgatct cggcccaggt ccgcgcatgt cgagcgagga gcagcagatt      480

gcgtacgagc tgtctcgctg cttcacgtgc ggcgcctgtg tcgaagcatg tcccaatgtg      540

aacgacaaga cgtcgttcat cggtccgttc gccatttctc aggcgcgcct gttcaacatg      600

cacccgacgg gcaagatgaa caaagaggag cgcctgcagg cgctgatggg cgaaggcggc      660

atcttcgagt gcggcaatgc gcagaactgc gtggaggtat gtccgaaggg cattccgctc      720

acgacgtcca tcgctgtgat gaaccgagag gtgacctacc gcgcgattgg cgcgtggctg      780

cgcaagtag                                                              789


<210>   1157
<211>   398
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1157
Met Met Asp Phe Ser Leu Ser Gln Glu Gln Met Ala Val Arg Asp Val 
                5                   10                  15      

Val Arg Lys Phe Val Asp Glu Glu Ile Leu Pro His Ile Arg Glu Trp 
            20                  25                  30          

Asp Glu Lys Gln His Phe Glu Pro Gly Val Leu Arg Arg Leu Ala Glu 
        35                  40                  45              

Leu Gly Leu Met Gly Val Cys Ile Pro Glu Lys Tyr Gly Gly Ala Gly 
    50                  55                  60                  

Met Asp Tyr Asn Thr Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly 
65                  70                  75                  80  

Asp Ile Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser 
                85                  90                  95      

Leu Thr Leu Leu Gln Trp Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu 
            100                 105                 110         

Val Pro Gln Ala Arg Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu 
        115                 120                 125             

Pro Asn Ala Gly Ser Asp Val Ala Ala Met Arg Thr Thr Ala Val Arg 
    130                 135                 140                 

Asp Gly Asp Ser Tyr Ile Leu Asn Gly Ser Lys Ile Trp Ile Ser Leu 
145                 150                 155                 160 

Ala Asp Val Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Arg Ser 
                165                 170                 175     

Lys Lys His His Gly Ile Thr Ala Phe Ile Val Glu Arg Gly Trp Glu 
            180                 185                 190         

Gly Phe Ser Thr Arg Ser Ile Lys Gly Lys Leu Gly Ile Arg Ala Gly 
        195                 200                 205             

Asn Thr Gly Glu Leu Phe Phe Asp His Val Arg Val Pro Ile Glu Asn 
    210                 215                 220                 

Arg Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu 
225                 230                 235                 240 

Asp Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Cys Gly Cys Ile Ala 
                245                 250                 255     

Ala Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Glu Thr Phe 
            260                 265                 270         

Gly Gln Pro Ile Gly Lys His Gln Leu Val Gln Gln Met Ile Ala Lys 
        275                 280                 285             

Met Ala Ala Asn Leu Asp Ile Ser Arg Leu Leu Val Tyr Arg Ala Gly 
    290                 295                 300                 

Trp Leu Lys Asn Gln Gly Leu Pro Asn Thr Arg Glu Thr Ser Leu Ala 
305                 310                 315                 320 

Lys Trp Val Ala Cys Asp Ala Ala Trp Glu Ala Ala Ser Asp Ala Val 
                325                 330                 335     

Gln Ile His Gly Ala Tyr Gly Tyr Ser Asn Glu Tyr Pro Val Glu Arg 
            340                 345                 350         

Tyr Leu Arg Asn Ala Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu 
        355                 360                 365             

Ile His Thr Ile Leu Gln Ala Glu Tyr Ala Leu Gly Tyr Arg Arg Asp 
    370                 375                 380                 

Lys Pro Leu Ser Arg Arg Leu Pro Ala Trp Pro Phe Glu Glu 
385                 390                 395             

<210>   1158
<211>   1197
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1158
gtgatggatt tcagcctgtc gcaagaacag atggcggttc gggacgtggt ccgcaagttc       60

gtggacgagg agatcttgcc ccacatccgc gagtgggacg agaaacagca ttttgagccg      120

ggcgtgctca ggcggctggc ggagctgggg ctcatgggcg tgtgtatccc cgagaagtac      180

ggcggcgcag ggatggacta caacacgctc gccattgtct gtgaagagct cgaacgggga      240

gacatcgcgt ttcgaacggc cgtatcggtc cacacaggac tcaattctct cacgctgctt      300

cagtggggga cggaggagca gaagcaaaag tatttggtgc ctcaggcgcg cggtgagaag      360

atcggggcgt ttggactcac cgagccgaac gcggggtcgg acgtggccgc gatgcggacg      420

accgccgtgc gggacggaga ttcgtatatt ttgaacgggt cgaagatctg gatttcgctc      480

gccgacgtcg cggaccactt cctggtcttt gcgtacaccg atcgctcgaa gaagcatcac      540

gggatcacgg cgttcatcgt ggagcgcggc tgggaagggt tctcgacgag atcgatcaag      600

ggcaagctcg gtattcgcgc aggcaacacg ggggaactgt tcttcgatca cgtccgcgtg      660

ccgatcgaga atcgacttgg agaagagggc gaaggcttca agattgccat gtccgccctc      720

gacaacgggc ggttcacggt ggcggccggc gcgtgcggat gcatcgcggc ttgcctcgag      780

gcgtcggtca agtactgcca tgagcgcgag acgtttggcc agcccatcgg caagcaccag      840

ctagtgcagc agatgattgc gaagatggcc gcgaacctgg acatctcccg cttgctggtc      900

taccgggctg ggtggctgaa gaaccagggc ttgccgaaca cgcgcgaaac ctcgctcgcg      960

aagtgggtgg cgtgtgatgc agcgtgggag gcggcgtcgg acgcggttca gattcacggc     1020

gcctacgggt attcgaacga gtatccggtg gagaggtacc tgcgaaacgc caaggcacct     1080

gtgatctatg aggggacgcg cgagatccac accatcctgc aggcggagta cgcgctcgga     1140

taccggcgag acaaaccgct gtcgcgccga cttccggcgt ggccgtttga agaatga        1197


<210>   1159
<211>   397
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   1159
Met His Phe Glu Leu Thr Glu Glu Gln Glu Leu Leu Lys Lys Thr Val 
                5                   10                  15      

Arg Asn Phe Val Asp Lys Glu Ile Met Pro Phe Ile Arg Glu Trp Asp 
            20                  25                  30          

Glu Asn His His Phe Glu Thr Gly Leu Leu Lys Lys Leu Ala Asp Leu 
        35                  40                  45              

Gly Leu Met Gly Val Cys Ile Pro Glu Lys Tyr Gly Gly Ser Gly Met 
    50                  55                  60                  

Asp Tyr Asn Ala Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly Asp 
65                  70                  75                  80  

Thr Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser Leu 
                85                  90                  95      

Thr Leu Leu Gln Trp Gly Thr Glu Ala Gln Lys Gln Lys Tyr Leu Val 
            100                 105                 110         

Pro Gln Ala Lys Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Val Ala Gly Ile Gly Thr Thr Ala Glu Lys Asp 
    130                 135                 140                 

Gly Asp Phe Tyr Ile Leu Asn Gly Gln Lys Thr Trp Ile Ser Leu Cys 
145                 150                 155                 160 

Asp Val Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Lys Ala Lys 
                165                 170                 175     

Lys His His Gly Ile Ser Ala Phe Ile Val Glu Arg Thr Met Pro Gly 
            180                 185                 190         

Phe Ser Ser Lys Ala Ile Lys Gly Lys Leu Gly Ile Arg Ala Gly Asn 
        195                 200                 205             

Thr Gly Glu Leu Phe Phe Asp Asn Val Arg Val Pro Lys Glu Asn Leu 
    210                 215                 220                 

Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu Asp 
225                 230                 235                 240 

Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Cys Gly Leu Ile Gln Ala 
                245                 250                 255     

Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Lys Thr Phe Gly 
            260                 265                 270         

His Glu Ile Gly Lys His Gln Leu Val Gln Gln Met Ile Ala Lys Met 
        275                 280                 285             

Glu Ala Gly Tyr Gln Met Ser Arg Leu Leu Val Phe Arg Ala Gly Glu 
    290                 295                 300                 

Leu Lys Asn Gln Gly Lys Arg Asn Thr Arg Glu Thr Ser Leu Ala Lys 
305                 310                 315                 320 

Trp Gln Ala Cys Asp Phe Ala Asn Glu Ala Ala Asn Asp Ala Val Gln 
                325                 330                 335     

Ile His Gly Ala Tyr Gly Tyr Ser Ser Glu Tyr Pro Val Glu Arg Tyr 
            340                 345                 350         

Leu Arg Asn Ser Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu Ile 
        355                 360                 365             

His Thr Ile Met Gln Ala Glu Tyr Val Leu Gly Tyr Arg Thr Asp Lys 
    370                 375                 380                 

Pro Leu Ser Lys Met Leu Pro Ala Trp Pro Phe Thr Glu 
385                 390                 395         

<210>   1160
<211>   397
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1160
Met Asn Phe Asp Phe Thr Pro Glu Gln Glu Met Leu Arg Gln Thr Val 
                5                   10                  15      

Arg Lys Phe Val Asp Lys Glu Ile Met Pro Tyr Ile Lys Glu Trp Asp 
            20                  25                  30          

Glu Arg Gly Glu Phe Asp Arg Asn Ile Phe Lys Arg Leu Ala Glu Leu 
        35                  40                  45              

Asn Leu Met Gly Val Cys Ile Pro Glu Gln Tyr Gly Gly Met Gly Met 
    50                  55                  60                  

Asp Tyr Asn Ser Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly Asp 
65                  70                  75                  80  

Thr Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser Leu 
                85                  90                  95      

Thr Leu Leu Gln Trp Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu Ile 
            100                 105                 110         

Pro Gln Ala Arg Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Asn Ala Gly Ser Asp Val Ala Ser Ile Gln Thr Thr Ala Val Arg Asp 
    130                 135                 140                 

Gly Asp Asp Tyr Ile Leu Asn Gly Gln Lys Thr Trp Ile Ser Leu Ala 
145                 150                 155                 160 

Asp Ile Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Lys Ser Lys 
                165                 170                 175     

Lys His Arg Gly Ile Ser Ala Phe Ile Val Glu Arg Thr Met Pro Gly 
            180                 185                 190         

Phe Ser Ser Arg Pro Ile Lys Gly Lys Leu Gly Ile Arg Ser Gly Asn 
        195                 200                 205             

Thr Gly Glu Leu Phe Phe Asp Asn Val Arg Val Pro Lys Glu Asn Leu 
    210                 215                 220                 

Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu Asp 
225                 230                 235                 240 

Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Val Gly Leu Ile Met Ala 
                245                 250                 255     

Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Lys Thr Phe Gly 
            260                 265                 270         

Lys Glu Ile Gly Arg His Gln Leu Val Gln Gln Met Ile Ala Arg Met 
        275                 280                 285             

Glu Ala Gly Leu Gln Ile Ser Arg Leu Leu Val Tyr Lys Val Gly Phe 
    290                 295                 300                 

Leu Lys Asn Glu Gly Arg Arg Cys Thr Arg Glu Thr Ser Leu Ala Lys 
305                 310                 315                 320 

Trp Ile Ala Cys Asp Tyr Ala Asn Gln Ala Ala Asp Asp Ala Val Gln 
                325                 330                 335     

Val His Gly Ala Tyr Gly Tyr Ser Asn Glu Tyr Pro Val Glu Arg Tyr 
            340                 345                 350         

Leu Arg Asn Ser Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu Ile 
        355                 360                 365             

His Thr Ile Met Gln Ala Glu Tyr Val Leu Gly Tyr Arg Lys Asp Lys 
    370                 375                 380                 

Pro Leu Arg Lys Thr Leu Pro Ala Trp Arg Pro Asp Glu 
385                 390                 395         

<210>   1161
<211>   393
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1161
Met Asn Phe Asp Phe Thr Pro Glu Gln Glu Met Leu Arg Gln Thr Val 
                5                   10                  15      

Arg Lys Phe Val Asp Lys Glu Ile Met Pro Tyr Ile Lys Glu Trp Asp 
            20                  25                  30          

Glu Arg Gly Glu Phe Asp Arg Asn Ile Phe Lys Arg Leu Ala Glu Leu 
        35                  40                  45              

Asn Leu Met Gly Val Cys Ile Pro Glu Glu Tyr Gly Gly Met Gly Met 
    50                  55                  60                  

Asp Tyr Asn Ser Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly Asp 
65                  70                  75                  80  

Thr Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser Leu 
                85                  90                  95      

Thr Leu Leu Gln Trp Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu Val 
            100                 105                 110         

Pro Gln Ala Arg Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Asn Ala Gly Ser Asp Val Ala Ser Ile Gln Thr Thr Ala Val Arg Asp 
    130                 135                 140                 

Gly Asp Asp Tyr Ile Leu Asn Gly Gln Lys Thr Trp Ile Ser Leu Ala 
145                 150                 155                 160 

Asp Ile Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Lys Ser Lys 
                165                 170                 175     

Lys His Arg Gly Ile Ser Ala Phe Ile Val Glu Arg Thr Met Pro Gly 
            180                 185                 190         

Phe Ser Ser Arg Pro Ile Lys Gly Lys Leu Gly Ile Arg Ser Gly Asn 
        195                 200                 205             

Thr Gly Glu Leu Phe Phe Asp Asn Val Arg Val Pro Lys Glu Asn Leu 
    210                 215                 220                 

Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu Asp 
225                 230                 235                 240 

Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Val Gly Leu Ile Met Ala 
                245                 250                 255     

Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Lys Thr Phe Gly 
            260                 265                 270         

Lys Glu Ile Gly Arg His Gln Leu Val Gln Gln Met Ile Ala Arg Met 
        275                 280                 285             

Glu Ala Gly Leu Gln Ile Ser Arg Leu Leu Val Tyr Lys Val Gly Phe 
    290                 295                 300                 

Leu Lys Asn Glu Gly Arg Arg Cys Thr Arg Glu Thr Ser Leu Ala Lys 
305                 310                 315                 320 

Trp Ile Ala Cys Asp Tyr Ala Asn Gln Ala Ala Asp Asp Ala Val Gln 
                325                 330                 335     

Ile His Gly Ala Tyr Gly Tyr Ser Asn Glu Tyr Pro Val Glu Arg Tyr 
            340                 345                 350         

Leu Arg Asn Ser Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu Ile 
        355                 360                 365             

His Thr Ile Met Gln Ala Glu Tyr Val Leu Gly Tyr Arg Gln Asp Lys 
    370                 375                 380                 

Pro Leu Arg Lys Thr Leu Pro Ala Trp 
385                 390             

<210>   1162
<211>   394
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   1162
Met Asp Phe His Phe Ser Glu Glu Gln Gln Leu Leu Arg Lys Thr Val 
                5                   10                  15      

Arg Asp Phe Thr Asp Lys Glu Ile Met Pro Tyr Ile Ser Glu Trp Asp 
            20                  25                  30          

Arg Asn Gly Lys Phe Asp Pro Thr Leu Leu Asn Lys Leu Ala Glu Leu 
        35                  40                  45              

Gly Leu Met Gly Val Cys Ile Pro Glu Gln Tyr Gly Gly Ser Gly Met 
    50                  55                  60                  

Asp Tyr Asn Ser Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly Asp 
65                  70                  75                  80  

Thr Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser Met 
                85                  90                  95      

Thr Leu Leu Gln Trp Gly Asn Glu Gln Gln Lys Gln Lys Tyr Leu Ile 
            100                 105                 110         

Pro Gln Ala Lys Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Val Ala Ala Leu Gln Ser Thr Ala Val Lys Gln 
    130                 135                 140                 

Gly Asp His Tyr Ile Leu Asn Gly Gln Lys Thr Trp Ile Ser Leu Cys 
145                 150                 155                 160 

Asp Ile Ala Asp His Phe Ile Val Phe Ala Tyr Thr Lys Asp Arg Ser 
                165                 170                 175     

Glu Lys His Lys Gly Ile Ser Ala Phe Ile Val Glu Arg Ser Trp Glu 
            180                 185                 190         

Gly Phe Ser Ser Lys Ala Ile Lys Gly Lys His Gly Ile Arg Ser Gly 
        195                 200                 205             

Asn Thr Gly Glu Ile Phe Phe Asp His Ile Lys Val Pro Lys Glu Asn 
    210                 215                 220                 

Leu Leu Gly Lys Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu 
225                 230                 235                 240 

Asp Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Val Gly Gln Ile Met 
                245                 250                 255     

Ala Cys Ile Glu Ala Ser Val Lys Tyr Cys His Glu Arg Glu Thr Phe 
            260                 265                 270         

Gly Lys Glu Ile Gly Lys His Gln Leu Val Gln Gln Met Ile Ala Lys 
        275                 280                 285             

Met Glu Ala Gly Tyr Gln Met Ser Lys Leu Leu Val Tyr Arg Ala Gly 
    290                 295                 300                 

Glu Leu Lys Asn Gln Gly Lys Arg Asn Thr Arg Glu Thr Ser Leu Ala 
305                 310                 315                 320 

Lys Trp Gln Ala Cys Asp Phe Ala Asn Lys Ala Ala Asp Asp Ala Val 
                325                 330                 335     

Gln Ile His Gly Ala Tyr Gly Tyr Ser Asp Glu Tyr Pro Val Glu Arg 
            340                 345                 350         

Phe Leu Arg Asn Ser Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu 
        355                 360                 365             

Val His Thr Ile Met Gln Ala Glu Tyr Val Leu Gly Tyr Arg Glu Asp 
    370                 375                 380                 

Lys Leu Leu Asn Gln Met Leu Pro Ala Trp 
385                 390                 

<210>   1163
<211>   397
<212>   PRT
<213>   Bacillus sp. B14905

<400>   1163
Met Asn Phe Asp Met Ser Thr Glu His Glu Met Leu Arg Lys Thr Val 
                5                   10                  15      

Arg Gln Phe Val Asp Glu Glu Ile Ile Pro Tyr Ile Ala Lys Trp Asp 
            20                  25                  30          

Ala Glu Gly Gly Phe Asp Ala Lys Ile Trp Ser Arg Leu Ala Glu Leu 
        35                  40                  45              

Gly Leu Met Gly Val Cys Val Pro Glu Gln Tyr Gly Gly Ser Gly Met 
    50                  55                  60                  

Asp Tyr Asn Ser Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly Asp 
65                  70                  75                  80  

Thr Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser Met 
                85                  90                  95      

Thr Leu Met Gln Trp Gly Thr Glu Asp Gln Lys Gln Arg Tyr Leu Ile 
            100                 105                 110         

Pro Gln Ala Lys Gly Val Arg Ile Gly Ala Phe Gly Leu Thr Glu Pro 
        115                 120                 125             

Gly Ala Gly Ser Asp Val Ala Ala Met Ser Thr Thr Ala Val Arg Asp 
    130                 135                 140                 

Gly Asp His Tyr Val Ile Asn Gly Gln Lys Thr Trp Ile Ser Leu Cys 
145                 150                 155                 160 

Asp Ile Ala Asp His Phe Ile Ile Phe Ala Tyr Thr Asp Lys Ser Lys 
                165                 170                 175     

Arg His His Gly Ile Ser Ala Phe Ile Val Glu Arg Ser Met Ala Gly 
            180                 185                 190         

Phe Thr Ser Lys Ala Ile Lys Gly Lys Tyr Gly Ile Arg Ala Gly Asn 
        195                 200                 205             

Thr Gly Glu Leu Phe Phe Glu Asp Leu Arg Val Pro Val Glu Asn Arg 
    210                 215                 220                 

Leu Gly Val Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu Asp 
225                 230                 235                 240 

Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Val Gly Leu Ile Gln Ala 
                245                 250                 255     

Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Glu Thr Phe Gly 
            260                 265                 270         

Lys Pro Ile Gly Glu His Gln Leu Val Gly Gln Met Ile Ala Asn Met 
        275                 280                 285             

Glu Ala Gly Tyr Gln Met Ser Arg Leu Leu Val Tyr Arg Val Gly Glu 
    290                 295                 300                 

Leu Lys Asn Lys Gly Val Arg Asn Thr Arg Glu Thr Ser Leu Ala Lys 
305                 310                 315                 320 

Trp Gln Ala Cys Asp Phe Ala Asn Lys Ala Ala Asp Asp Ala Val Gln 
                325                 330                 335     

Ile His Gly Ala Tyr Gly Tyr Ser Asp Glu Tyr Pro Val Ala Arg Tyr 
            340                 345                 350         

Leu Arg Asn Ser Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu Ile 
        355                 360                 365             

His Thr Ile Met Gln Ala Asp Tyr Val Leu Gly Arg Arg Gln Asp Lys 
    370                 375                 380                 

Pro Leu Ala Asn Arg Leu Pro Lys Trp Pro Phe Glu Glu 
385                 390                 395         

<210>   1164
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1157

<400>   1164
Met Met Asp Phe Ser Leu Ser Gln Glu Gln Met Ala Val Arg Asp Val 
                5                   10                  15      

Val Arg Lys Phe Val Asp Glu Glu Ile Leu Pro His Ile Arg Glu Trp 
            20                  25                  30          

Asp Glu Lys Gln His Phe Glu Pro Gly Val Ile Arg Arg Leu Ala Glu 
        35                  40                  45              

Leu Gly Leu Met Gly Val Cys Ile Pro Glu Lys Tyr Gly Gly Ala Gly 
    50                  55                  60                  

Met Asp Tyr Asn Thr Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly 
65                  70                  75                  80  

Asp Ile Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser 
                85                  90                  95      

Leu Thr Leu Leu Gln Trp Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu 
            100                 105                 110         

Val Pro Gln Ala Arg Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu 
        115                 120                 125             

Pro Asn Ala Gly Ser Asp Val Ala Ala Met Arg Thr Thr Ala Val Arg 
    130                 135                 140                 

Asp Gly Asp Ser Tyr Ile Leu Asn Gly Ser Lys Ile Trp Ile Ser Leu 
145                 150                 155                 160 

Ala Asp Val Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Arg Ser 
                165                 170                 175     

Lys Lys His His Gly Ile Thr Ala Phe Ile Val Glu Arg Gly Trp Glu 
            180                 185                 190         

Gly Phe Ser Thr Arg Ser Ile Lys Gly Lys Leu Gly Ile Arg Ala Gly 
        195                 200                 205             

Asn Thr Gly Glu Leu Phe Phe Asp His Val Arg Val Pro Ile Glu Asn 
    210                 215                 220                 

Arg Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu 
225                 230                 235                 240 

Asp Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Cys Gly Cys Ile Ala 
                245                 250                 255     

Ala Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Glu Thr Phe 
            260                 265                 270         

Gly Gln Pro Ile Gly Lys His Gln Leu Val Gln Gln Met Ile Ala Lys 
        275                 280                 285             

Met Ala Ala Asn Leu Asp Ile Ser Arg Leu Leu Val Tyr Arg Ala Gly 
    290                 295                 300                 

Trp Leu Lys Asn Gln Gly Leu Pro Asn Thr Arg Glu Thr Ser Leu Ala 
305                 310                 315                 320 

Lys Trp Val Ala Cys Asp Ala Ala Trp Glu Ala Ala Ser Asp Ala Val 
                325                 330                 335     

Gln Ile His Gly Ala Tyr Gly Tyr Ser Asn Glu Tyr Pro Val Glu Arg 
            340                 345                 350         

Tyr Leu Arg Asn Ala Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu 
        355                 360                 365             

Ile His Thr Ile Leu Gln Ala Glu Tyr Ala Leu Gly Tyr Arg Arg Asp 
    370                 375                 380                 

Lys Pro Leu Ser Arg Arg Leu Pro Ala Trp Pro Phe Glu Glu 
385                 390                 395             

<210>   1165
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1157

<400>   1165
Met Met Asp Phe Ser Leu Ser Asn Glu Gln Met Ala Val Arg Asp Val 
                5                   10                  15      

Val Arg Lys Phe Val Asp Glu Glu Ile Leu Pro His Ile Arg Glu Trp 
            20                  25                  30          

Asp Glu Lys Gln His Phe Glu Pro Gly Val Leu Arg Arg Leu Ala Glu 
        35                  40                  45              

Leu Gly Leu Met Gly Val Cys Ile Pro Glu Lys Tyr Gly Gly Ala Gly 
    50                  55                  60                  

Met Asp Tyr Asn Thr Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly 
65                  70                  75                  80  

Asp Ile Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser 
                85                  90                  95      

Leu Thr Leu Leu Gln Trp Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu 
            100                 105                 110         

Val Pro Gln Ala Arg Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu 
        115                 120                 125             

Pro Asn Ala Gly Ser Asp Val Ala Ala Met Arg Thr Thr Ala Val Arg 
    130                 135                 140                 

Asp Gly Asp Ser Tyr Ile Leu Asn Gly Ser Lys Ile Trp Ile Ser Leu 
145                 150                 155                 160 

Ala Asp Val Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Arg Ser 
                165                 170                 175     

Lys Lys His His Gly Ile Thr Ala Phe Ile Val Glu Arg Gly Trp Glu 
            180                 185                 190         

Gly Phe Ser Thr Arg Ser Ile Lys Gly Lys Leu Gly Ile Arg Ala Gly 
        195                 200                 205             

Asn Thr Gly Glu Leu Phe Phe Asp His Val Arg Val Pro Ile Glu Asn 
    210                 215                 220                 

Arg Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu 
225                 230                 235                 240 

Asp Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Cys Gly Cys Ile Ala 
                245                 250                 255     

Ala Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Glu Thr Phe 
            260                 265                 270         

Gly Gln Pro Ile Gly Lys His Gln Leu Val Gln Gln Met Ile Ala Lys 
        275                 280                 285             

Met Ala Ala Asn Leu Asp Ile Ser Arg Leu Leu Val Tyr Arg Ala Gly 
    290                 295                 300                 

Trp Leu Lys Asn Gln Gly Leu Pro Asn Thr Arg Glu Thr Ser Leu Ala 
305                 310                 315                 320 

Lys Trp Val Ala Cys Asp Ala Ala Trp Glu Ala Ala Ser Asp Ala Val 
                325                 330                 335     

Gln Ile His Gly Ala Tyr Gly Tyr Ser Asn Glu Tyr Pro Val Glu Arg 
            340                 345                 350         

Tyr Leu Arg Asn Ala Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu 
        355                 360                 365             

Ile His Thr Ile Leu Gln Ala Glu Tyr Ala Leu Gly Tyr Arg Arg Asp 
    370                 375                 380                 

Lys Pro Leu Ser Arg Arg Leu Pro Ala Trp Pro Phe Glu Glu 
385                 390                 395             

<210>   1166
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1157

<400>   1166
Met Met Asp Phe Ser Leu Ser Gln Glu Gln Met Ala Val Arg Asp Val 
                5                   10                  15      

Val Arg Lys Phe Val Asp Glu Glu Ile Leu Pro His Ile Arg Glu Trp 
            20                  25                  30          

Asp Glu Lys Gln His Phe Glu Pro Gly Val Leu Arg Arg Leu Ala Glu 
        35                  40                  45              

Leu Gly Leu Met Gly Val Cys Ile Pro Glu Lys Tyr Gly Gly Ala Gly 
    50                  55                  60                  

Met Asp Tyr Asn Thr Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly 
65                  70                  75                  80  

Asp Ile Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser 
                85                  90                  95      

Leu Thr Leu Leu Gln Trp Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu 
            100                 105                 110         

Val Pro Gln Ala Arg Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu 
        115                 120                 125             

Pro Asn Ala Gly Ser Asp Val Ala Ala Met Arg Thr Thr Ala Val Arg 
    130                 135                 140                 

Asp Gly Asp Ser Tyr Ile Leu Asn Gly Ser Lys Ile Trp Ile Ser Leu 
145                 150                 155                 160 

Ala Asp Val Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Arg Ser 
                165                 170                 175     

Lys Lys His His Gly Ile Thr Ala Phe Ile Val Glu Arg Gly Trp Glu 
            180                 185                 190         

Gly Phe Ser Thr Arg Ser Ile Lys Gly Lys Leu Gly Ile Arg Ala Gly 
        195                 200                 205             

Asn Thr Gly Glu Leu Phe Phe Asp His Val Arg Val Pro Ile Glu Asn 
    210                 215                 220                 

Arg Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu 
225                 230                 235                 240 

Asp Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Cys Gly Cys Ile Ala 
                245                 250                 255     

Ala Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Glu Thr Phe 
            260                 265                 270         

Gly Gln Pro Ile Gly Lys His Gln Leu Val Gln Gln Met Ile Ala Lys 
        275                 280                 285             

Met Ala Ala Asn Leu Asp Ile Ser Arg Leu Leu Val Tyr Arg Ala Gly 
    290                 295                 300                 

Trp Leu Lys Asn Gln Gly Leu Pro Gln Thr Arg Glu Thr Ser Leu Ala 
305                 310                 315                 320 

Lys Trp Val Ala Cys Asp Ala Ala Trp Glu Ala Ala Ser Asp Ala Val 
                325                 330                 335     

Gln Ile His Gly Ala Tyr Gly Tyr Ser Asn Glu Tyr Pro Val Glu Arg 
            340                 345                 350         

Tyr Leu Arg Asn Ala Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu 
        355                 360                 365             

Ile His Thr Ile Leu Gln Ala Glu Tyr Ala Leu Gly Tyr Arg Arg Asp 
    370                 375                 380                 

Lys Pro Leu Ser Arg Arg Leu Pro Ala Trp Pro Phe Glu Glu 
385                 390                 395             

<210>   1167
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1157

<400>   1167
Met Met Asp Phe Ser Leu Ser Gln Glu Gln Met Ala Val Arg Asp Val 
                5                   10                  15      

Val Arg Lys Phe Val Asp Glu Glu Ile Leu Pro His Ile Arg Glu Trp 
            20                  25                  30          

Asp Glu Lys Gln His Phe Glu Pro Gly Val Leu Arg Arg Leu Ala Glu 
        35                  40                  45              

Leu Gly Leu Met Gly Val Cys Ile Pro Glu Lys Tyr Gly Gly Ala Gly 
    50                  55                  60                  

Met Asp Tyr Asn Thr Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly 
65                  70                  75                  80  

Asp Ile Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser 
                85                  90                  95      

Leu Thr Leu Leu Gln Trp Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu 
            100                 105                 110         

Val Pro Gln Ala Arg Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu 
        115                 120                 125             

Pro Asn Ala Gly Ser Asp Val Ala Ala Met Arg Thr Thr Ala Val Arg 
    130                 135                 140                 

Asp Gly Asp Ser Tyr Ile Leu Asn Gly Ser Lys Ile Trp Ile Ser Leu 
145                 150                 155                 160 

Ala Asp Val Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Arg Ser 
                165                 170                 175     

Lys Lys His His Gly Ile Thr Ala Phe Ile Val Glu Arg Gly Trp Glu 
            180                 185                 190         

Gly Phe Ser Thr Arg Ser Ile Lys Gly Lys Leu Gly Ile Arg Ala Gly 
        195                 200                 205             

Asn Thr Gly Glu Leu Phe Phe Asp His Val Arg Val Pro Leu Glu Asn 
    210                 215                 220                 

Arg Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu 
225                 230                 235                 240 

Asp Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Cys Gly Cys Ile Ala 
                245                 250                 255     

Ala Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Glu Thr Phe 
            260                 265                 270         

Gly Gln Pro Ile Gly Lys His Gln Leu Val Gln Gln Met Ile Ala Lys 
        275                 280                 285             

Met Ala Ala Asn Leu Asp Ile Ser Arg Leu Leu Val Tyr Arg Ala Gly 
    290                 295                 300                 

Trp Leu Lys Asn Gln Gly Leu Pro Asn Thr Arg Glu Thr Ser Leu Ala 
305                 310                 315                 320 

Lys Trp Val Ala Cys Asp Ala Ala Trp Glu Ala Ala Ser Asp Ala Val 
                325                 330                 335     

Gln Ile His Gly Ala Tyr Gly Tyr Ser Asn Glu Tyr Pro Val Glu Arg 
            340                 345                 350         

Tyr Leu Arg Asn Ala Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu 
        355                 360                 365             

Ile His Thr Ile Leu Gln Ala Glu Tyr Ala Leu Gly Tyr Arg Arg Asp 
    370                 375                 380                 

Lys Pro Leu Ser Arg Arg Leu Pro Ala Trp Pro Phe Glu Glu 
385                 390                 395             

<210>   1168
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1157

<400>   1168
Met Met Asp Phe Ser Leu Ser Gln Glu Gln Met Ala Val Arg Asp Val 
                5                   10                  15      

Val Arg Lys Phe Val Asp Glu Glu Ile Leu Pro His Ile Arg Glu Trp 
            20                  25                  30          

Asp Glu Lys Gln His Phe Glu Pro Gly Val Leu Arg Arg Leu Ala Glu 
        35                  40                  45              

Leu Gly Leu Met Gly Val Cys Ile Pro Glu Lys Tyr Gly Gly Ala Gly 
    50                  55                  60                  

Met Asp Tyr Asn Thr Leu Ala Ile Val Cys Glu Glu Leu Glu Arg Gly 
65                  70                  75                  80  

Asp Ile Ala Phe Arg Thr Ala Val Ser Val His Thr Gly Leu Asn Ser 
                85                  90                  95      

Leu Thr Leu Leu Gln Trp Gly Thr Glu Glu Gln Lys Gln Lys Tyr Leu 
            100                 105                 110         

Val Pro Gln Ala Arg Gly Glu Lys Ile Gly Ala Phe Gly Leu Thr Glu 
        115                 120                 125             

Pro Asn Ala Gly Ser Asp Val Ala Ala Met Arg Thr Thr Ala Ile Arg 
    130                 135                 140                 

Asp Gly Asp Ser Tyr Ile Leu Asn Gly Ser Lys Ile Trp Ile Ser Leu 
145                 150                 155                 160 

Ala Asp Val Ala Asp His Phe Leu Val Phe Ala Tyr Thr Asp Arg Ser 
                165                 170                 175     

Lys Lys His His Gly Ile Thr Ala Phe Ile Val Glu Arg Gly Trp Glu 
            180                 185                 190         

Gly Phe Ser Thr Arg Ser Ile Lys Gly Lys Leu Gly Ile Arg Ala Gly 
        195                 200                 205             

Asn Thr Gly Glu Leu Phe Phe Asp His Val Arg Val Pro Ile Glu Asn 
    210                 215                 220                 

Arg Leu Gly Glu Glu Gly Glu Gly Phe Lys Ile Ala Met Ser Ala Leu 
225                 230                 235                 240 

Asp Asn Gly Arg Phe Thr Val Ala Ala Gly Ala Cys Gly Cys Ile Ala 
                245                 250                 255     

Ala Cys Leu Glu Ala Ser Val Lys Tyr Cys His Glu Arg Glu Thr Phe 
            260                 265                 270         

Gly Gln Pro Ile Gly Lys His Gln Leu Val Gln Gln Met Ile Ala Lys 
        275                 280                 285             

Met Ala Ala Asn Leu Asp Ile Ser Arg Leu Leu Val Tyr Arg Ala Gly 
    290                 295                 300                 

Trp Leu Lys Asn Gln Gly Leu Pro Asn Thr Arg Glu Thr Ser Leu Ala 
305                 310                 315                 320 

Lys Trp Val Ala Cys Asp Ala Ala Trp Glu Ala Ala Ser Asp Ala Val 
                325                 330                 335     

Gln Ile His Gly Ala Tyr Gly Tyr Ser Asn Glu Tyr Pro Val Glu Arg 
            340                 345                 350         

Tyr Leu Arg Asn Ala Lys Ala Pro Val Ile Tyr Glu Gly Thr Arg Glu 
        355                 360                 365             

Ile His Thr Ile Leu Gln Ala Glu Tyr Ala Leu Gly Tyr Arg Arg Asp 
    370                 375                 380                 

Lys Pro Leu Ser Arg Arg Leu Pro Ala Trp Pro Phe Glu Glu 
385                 390                 395             

<210>   1169
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1158

<400>   1169
gtgatggatt tcagcctgtc gcaagaacag atggcggttc gggacgtggt ccgcaagttc       60

gtggacgagg agatcttgcc ccacatccgc gagtgggacg agaaacagca ttttgagccg      120

ggcgtgatta ggcggctggc ggagctgggg ctcatgggcg tgtgtatccc cgagaagtac      180

ggcggcgcag ggatggacta caacacgctc gccattgtct gtgaagagct cgaacgggga      240

gacatcgcgt ttcgaacggc cgtatcggtc cacacaggac tcaattctct cacgctgctt      300

cagtggggga cggaggagca gaagcaaaag tatttggtgc ctcaggcgcg cggtgagaag      360

atcggggcgt ttggactcac cgagccgaac gcggggtcgg acgtggccgc gatgcggacg      420

accgccgtgc gggacggaga ttcgtatatt ttgaacgggt cgaagatctg gatttcgctc      480

gccgacgtcg cggaccactt cctggtcttt gcgtacaccg atcgctcgaa gaagcatcac      540

gggatcacgg cgttcatcgt ggagcgcggc tgggaagggt tctcgacgag atcgatcaag      600

ggcaagctcg gtattcgcgc aggcaacacg ggggaactgt tcttcgatca cgtccgcgtg      660

ccgatcgaga atcgacttgg agaagagggc gaaggcttca agattgccat gtccgccctc      720

gacaacgggc ggttcacggt ggcggccggc gcgtgcggat gcatcgcggc ttgcctcgag      780

gcgtcggtca agtactgcca tgagcgcgag acgtttggcc agcccatcgg caagcaccag      840

ctagtgcagc agatgattgc gaagatggcc gcgaacctgg acatctcccg cttgctggtc      900

taccgggctg ggtggctgaa gaaccagggc ttgccgaaca cgcgcgaaac ctcgctcgcg      960

aagtgggtgg cgtgtgatgc agcgtgggag gcggcgtcgg acgcggttca gattcacggc     1020

gcctacgggt attcgaacga gtatccggtg gagaggtacc tgcgaaacgc caaggcacct     1080

gtgatctatg aggggacgcg cgagatccac accatcctgc aggcggagta cgcgctcgga     1140

taccggcgag acaaaccgct gtcgcgccga cttccggcgt ggccgtttga agaatga        1197


<210>   1170
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1158

<400>   1170
gtgatggatt tcagcctgtc gaatgaacag atggcggttc gggacgtggt ccgcaagttc       60

gtggacgagg agatcttgcc ccacatccgc gagtgggacg agaaacagca ttttgagccg      120

ggcgtgctca ggcggctggc ggagctgggg ctcatgggcg tgtgtatccc cgagaagtac      180

ggcggcgcag ggatggacta caacacgctc gccattgtct gtgaagagct cgaacgggga      240

gacatcgcgt ttcgaacggc cgtatcggtc cacacaggac tcaattctct cacgctgctt      300

cagtggggga cggaggagca gaagcaaaag tatttggtgc ctcaggcgcg cggtgagaag      360

atcggggcgt ttggactcac cgagccgaac gcggggtcgg acgtggccgc gatgcggacg      420

accgccgtgc gggacggaga ttcgtatatt ttgaacgggt cgaagatctg gatttcgctc      480

gccgacgtcg cggaccactt cctggtcttt gcgtacaccg atcgctcgaa gaagcatcac      540

gggatcacgg cgttcatcgt ggagcgcggc tgggaagggt tctcgacgag atcgatcaag      600

ggcaagctcg gtattcgcgc aggcaacacg ggggaactgt tcttcgatca cgtccgcgtg      660

ccgatcgaga atcgacttgg agaagagggc gaaggcttca agattgccat gtccgccctc      720

gacaacgggc ggttcacggt ggcggccggc gcgtgcggat gcatcgcggc ttgcctcgag      780

gcgtcggtca agtactgcca tgagcgcgag acgtttggcc agcccatcgg caagcaccag      840

ctagtgcagc agatgattgc gaagatggcc gcgaacctgg acatctcccg cttgctggtc      900

taccgggctg ggtggctgaa gaaccagggc ttgccgaaca cgcgcgaaac ctcgctcgcg      960

aagtgggtgg cgtgtgatgc agcgtgggag gcggcgtcgg acgcggttca gattcacggc     1020

gcctacgggt attcgaacga gtatccggtg gagaggtacc tgcgaaacgc caaggcacct     1080

gtgatctatg aggggacgcg cgagatccac accatcctgc aggcggagta cgcgctcgga     1140

taccggcgag acaaaccgct gtcgcgccga cttccggcgt ggccgtttga agaatga        1197


<210>   1171
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1158

<400>   1171
gtgatggatt tcagcctgtc gcaagaacag atggcggttc gggacgtggt ccgcaagttc       60

gtggacgagg agatcttgcc ccacatccgc gagtgggacg agaaacagca ttttgagccg      120

ggcgtgctca ggcggctggc ggagctgggg ctcatgggcg tgtgtatccc cgagaagtac      180

ggcggcgcag ggatggacta caacacgctc gccattgtct gtgaagagct cgaacgggga      240

gacatcgcgt ttcgaacggc cgtatcggtc cacacaggac tcaattctct cacgctgctt      300

cagtggggga cggaggagca gaagcaaaag tatttggtgc ctcaggcgcg cggtgagaag      360

atcggggcgt ttggactcac cgagccgaac gcggggtcgg acgtggccgc gatgcggacg      420

accgccgtgc gggacggaga ttcgtatatt ttgaacgggt cgaagatctg gatttcgctc      480

gccgacgtcg cggaccactt cctggtcttt gcgtacaccg atcgctcgaa gaagcatcac      540

gggatcacgg cgttcatcgt ggagcgcggc tgggaagggt tctcgacgag atcgatcaag      600

ggcaagctcg gtattcgcgc aggcaacacg ggggaactgt tcttcgatca cgtccgcgtg      660

ccgatcgaga atcgacttgg agaagagggc gaaggcttca agattgccat gtccgccctc      720

gacaacgggc ggttcacggt ggcggccggc gcgtgcggat gcatcgcggc ttgcctcgag      780

gcgtcggtca agtactgcca tgagcgcgag acgtttggcc agcccatcgg caagcaccag      840

ctagtgcagc agatgattgc gaagatggcc gcgaacctgg acatctcccg cttgctggtc      900

taccgggctg ggtggctgaa gaaccagggc ttgccgcaaa cgcgcgaaac ctcgctcgcg      960

aagtgggtgg cgtgtgatgc agcgtgggag gcggcgtcgg acgcggttca gattcacggc     1020

gcctacgggt attcgaacga gtatccggtg gagaggtacc tgcgaaacgc caaggcacct     1080

gtgatctatg aggggacgcg cgagatccac accatcctgc aggcggagta cgcgctcgga     1140

taccggcgag acaaaccgct gtcgcgccga cttccggcgt ggccgtttga agaatga        1197


<210>   1172
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1158

<400>   1172
gtgatggatt tcagcctgtc gcaagaacag atggcggttc gggacgtggt ccgcaagttc       60

gtggacgagg agatcttgcc ccacatccgc gagtgggacg agaaacagca ttttgagccg      120

ggcgtgctca ggcggctggc ggagctgggg ctcatgggcg tgtgtatccc cgagaagtac      180

ggcggcgcag ggatggacta caacacgctc gccattgtct gtgaagagct cgaacgggga      240

gacatcgcgt ttcgaacggc cgtatcggtc cacacaggac tcaattctct cacgctgctt      300

cagtggggga cggaggagca gaagcaaaag tatttggtgc ctcaggcgcg cggtgagaag      360

atcggggcgt ttggactcac cgagccgaac gcggggtcgg acgtggccgc gatgcggacg      420

accgccgtgc gggacggaga ttcgtatatt ttgaacgggt cgaagatctg gatttcgctc      480

gccgacgtcg cggaccactt cctggtcttt gcgtacaccg atcgctcgaa gaagcatcac      540

gggatcacgg cgttcatcgt ggagcgcggc tgggaagggt tctcgacgag atcgatcaag      600

ggcaagctcg gtattcgcgc aggcaacacg ggggaactgt tcttcgatca cgtccgcgtg      660

ccgttagaga atcgacttgg agaagagggc gaaggcttca agattgccat gtccgccctc      720

gacaacgggc ggttcacggt ggcggccggc gcgtgcggat gcatcgcggc ttgcctcgag      780

gcgtcggtca agtactgcca tgagcgcgag acgtttggcc agcccatcgg caagcaccag      840

ctagtgcagc agatgattgc gaagatggcc gcgaacctgg acatctcccg cttgctggtc      900

taccgggctg ggtggctgaa gaaccagggc ttgccgaaca cgcgcgaaac ctcgctcgcg      960

aagtgggtgg cgtgtgatgc agcgtgggag gcggcgtcgg acgcggttca gattcacggc     1020

gcctacgggt attcgaacga gtatccggtg gagaggtacc tgcgaaacgc caaggcacct     1080

gtgatctatg aggggacgcg cgagatccac accatcctgc aggcggagta cgcgctcgga     1140

taccggcgag acaaaccgct gtcgcgccga cttccggcgt ggccgtttga agaatga        1197


<210>   1173
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1158

<400>   1173
gtgatggatt tcagcctgtc gcaagaacag atggcggttc gggacgtggt ccgcaagttc       60

gtggacgagg agatcttgcc ccacatccgc gagtgggacg agaaacagca ttttgagccg      120

ggcgtgctca ggcggctggc ggagctgggg ctcatgggcg tgtgtatccc cgagaagtac      180

ggcggcgcag ggatggacta caacacgctc gccattgtct gtgaagagct cgaacgggga      240

gacatcgcgt ttcgaacggc cgtatcggtc cacacaggac tcaattctct cacgctgctt      300

cagtggggga cggaggagca gaagcaaaag tatttggtgc ctcaggcgcg cggtgagaag      360

atcggggcgt ttggactcac cgagccgaac gcggggtcgg acgtggccgc gatgcggacg      420

accgccattc gggacggaga ttcgtatatt ttgaacgggt cgaagatctg gatttcgctc      480

gccgacgtcg cggaccactt cctggtcttt gcgtacaccg atcgctcgaa gaagcatcac      540

gggatcacgg cgttcatcgt ggagcgcggc tgggaagggt tctcgacgag atcgatcaag      600

ggcaagctcg gtattcgcgc aggcaacacg ggggaactgt tcttcgatca cgtccgcgtg      660

ccgatcgaga atcgacttgg agaagagggc gaaggcttca agattgccat gtccgccctc      720

gacaacgggc ggttcacggt ggcggccggc gcgtgcggat gcatcgcggc ttgcctcgag      780

gcgtcggtca agtactgcca tgagcgcgag acgtttggcc agcccatcgg caagcaccag      840

ctagtgcagc agatgattgc gaagatggcc gcgaacctgg acatctcccg cttgctggtc      900

taccgggctg ggtggctgaa gaaccagggc ttgccgaaca cgcgcgaaac ctcgctcgcg      960

aagtgggtgg cgtgtgatgc agcgtgggag gcggcgtcgg acgcggttca gattcacggc     1020

gcctacgggt attcgaacga gtatccggtg gagaggtacc tgcgaaacgc caaggcacct     1080

gtgatctatg aggggacgcg cgagatccac accatcctgc aggcggagta cgcgctcgga     1140

taccggcgag acaaaccgct gtcgcgccga cttccggcgt ggccgtttga agaatga        1197


<210>   1174
<211>   680
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1174
Met Ile Val Thr Gln Glu Ile Thr Ala Leu Gln Gln Leu Val Asp Arg 
                5                   10                  15      

Ser Arg Arg Leu Gly Ala Asp Arg Ser Ile Cys Asn Trp Gly Gly Gly 
            20                  25                  30          

Asn Thr Ser Ala Lys Thr Thr Met Leu Asp His Met Gly Arg Glu Ile 
        35                  40                  45              

Arg Val Met Trp Val Lys Gly Ser Gly Ser Asp Leu Ala Glu Ala Thr 
    50                  55                  60                  

Glu Lys Ser Phe Thr Ala Leu Arg Leu Asp Glu Val Leu Pro Leu Met 
65                  70                  75                  80  

Glu Arg Asp Ala Met Thr Asp Glu Glu Met Val Asp Tyr Leu Ala His 
                85                  90                  95      

Cys Met Val Glu Ala Lys His Pro Arg Ser Ser Ile Glu Thr Leu Leu 
            100                 105                 110         

His Ala Phe Ile Pro His Thr His Val Asp His Thr His Pro Asp Ser 
        115                 120                 125             

Ile Ile Ala Ile Cys Thr Ser Thr Asn Gly Arg Glu Val Ala Lys Glu 
    130                 135                 140                 

Ile Phe Gly Asp Arg Ala Val Trp Val Pro Tyr Leu Arg Pro Gly Phe 
145                 150                 155                 160 

Ala Leu Ser Lys Leu Val Ala Glu Ala Val Arg Ala Asn Pro Gln Cys 
                165                 170                 175     

Glu Cys Val Leu Met Glu Lys His Gly Leu Ile Thr Trp Gly Glu Thr 
            180                 185                 190         

Ser Glu Ala Cys Tyr Ala Asn Thr Val Arg Ile Ile Gly Glu Ala Ala 
        195                 200                 205             

Glu Tyr Leu Glu Ala Lys Gln Arg Gly Arg Val Ala Phe Gly Gly Val 
    210                 215                 220                 

Lys His Pro Ala Leu Pro Gln Glu Glu Arg Arg Arg Ile Ala Val Gln 
225                 230                 235                 240 

Ile Leu Pro Phe Val Arg Gly Ile Val Ser Glu Arg Gln Gly Ala Ile 
                245                 250                 255     

Leu Ser Phe Asp Asp Ser Pro Glu Phe Leu Glu Phe Ala Gly Ser His 
            260                 265                 270         

Asp Ala Pro Ser Leu Ser Gln Val Gly Ala Ala Cys Pro Asp His Leu 
        275                 280                 285             

Val His Thr Lys Arg Arg Pro Leu Phe Val Asp Trp Ser Pro Ser Glu 
    290                 295                 300                 

Gly Val Asp Ala Leu Lys Glu Lys Leu Lys Ala Gly Leu Thr Ala Tyr 
305                 310                 315                 320 

Arg Asp Asp Tyr Thr Ala Tyr Tyr Glu Arg Asn Val Asp Leu Asp Val 
                325                 330                 335     

Pro Met His Asp Pro Phe Pro Arg Ile Leu Leu Ile Pro Gly Leu Gly 
            340                 345                 350         

Val Ile Gly Thr Gly Lys Asn Lys Lys Met Ala Asn Ile Ala Leu Asp 
        355                 360                 365             

Leu Tyr Arg Arg Ala Ile Glu Val Met Arg Gly Ala Thr Ala Ile Gly 
    370                 375                 380                 

Glu Phe Val Ser Leu Asp Glu Lys Glu Ser Phe Asp Val Glu Tyr Trp 
385                 390                 395                 400 

Pro Leu Glu Leu Tyr Lys Leu Thr Leu Ala Pro Pro Glu Lys Glu Leu 
                405                 410                 415     

Ser Arg Lys Val Ala Tyr Ile Thr Gly Gly Ala Gly Gly Ile Gly Ser 
            420                 425                 430         

Ala Thr Ala Arg Arg Leu Ala Glu Glu Gly Ala His Val Val Ile Ala 
        435                 440                 445             

Asp Leu Ala Ala Asp Ala Ala Arg Arg Leu Ala Glu Glu Leu Cys Ala 
    450                 455                 460                 

Asp His Gly Pro Gly Thr Ala Ile Gly Val Ala Leu Asp Val Thr Gln 
465                 470                 475                 480 

Glu Asp Ala Val Val Arg Ser Ile Glu Glu Ala Ile Leu Ala Tyr Gly 
                485                 490                 495     

Gly Ile Asp Leu Phe Val Ser Asn Ala Gly Leu Ala Ser Ser Ala Pro 
            500                 505                 510         

Val Thr Glu Thr Ser Leu Ala Glu Trp Asn Lys Asn Val Ala Val Leu 
        515                 520                 525             

Gly Thr Gly Tyr Phe Leu Thr Ser Arg Glu Ala Phe Arg Val Met Val 
    530                 535                 540                 

Glu Gln Gly Arg Gly Gly Ala Val Val Phe Val Thr Ser Lys Asn Ala 
545                 550                 555                 560 

Val Tyr Ala Gly Lys Asp Ala Ser Ala Tyr Ser Ala Ala Lys Ala Met 
                565                 570                 575     

Glu Asn His Leu Ala Arg Cys Leu Ala Val Glu Gly Gly Pro His Gly 
            580                 585                 590         

Ile Arg Val Asn Ile Val Met Pro Asp Ala Val Leu Gln Gly Ser Asn 
        595                 600                 605             

Ile Trp Asn Ser Ala Trp Arg Glu Glu Arg Ala Arg Ala Tyr Gly Ile 
    610                 615                 620                 

Ala Pro Glu Glu Leu Glu Asp Tyr Tyr Arg Arg Arg Thr Ile Leu Gly 
625                 630                 635                 640 

Val Asn Ile Leu Pro Glu Asp Ile Ala Glu Ala Ile Leu Phe Phe Cys 
                645                 650                 655     

Ser Pro Arg Ser Ala Lys Thr Thr Gly Cys Met Leu Thr Val Asp Gly 
            660                 665                 670         

Gly Val Ala Ala Ala Phe Pro Arg 
        675                 680 

<210>   1175
<211>   2043
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1175
gtgatcgtca cacaggaaat aaccgctctc cagcaacttg tcgaccgatc tcgccgcctc       60

ggcgcggatc gcagcatatg caattggggt gggggaaaca cgtccgccaa gaccaccatg      120

ctcgatcaca tgggccgcga gatccgcgtc atgtgggtga aaggcagcgg ctccgacctc      180

gccgaggcga cggagaagag cttcaccgcg ctgcgtctgg atgaggtgct gccgctcatg      240

gagcgcgacg cgatgacgga cgaggagatg gtcgactacc tcgcgcactg catggtagag      300

gccaagcatc cgcgatcgtc catcgagaca ctgctccacg ccttcatccc gcacacgcat      360

gtggatcaca cgcacccgga cagcatcatc gccatctgca cgagcacaaa cgggcgcgag      420

gtggcgaagg agatcttcgg cgatcgcgcc gtgtgggtcc cgtatctgcg gccggggttc      480

gcgctgtcca agctggtcgc ggaggccgtg cgggcgaacc cccaatgcga gtgcgtgctg      540

atggagaagc atggtctcat cacctggggc gaaacgtccg aagcatgcta cgccaacacc      600

gtgcgcatca ttggtgaagc tgcggagtac ctcgaagcga aacaacgggg acgcgtggcc      660

ttcggcggtg tgaaacatcc cgcgctgcca caggaagaac ggcgccgcat cgccgtgcag      720

atcctgccgt tcgtccgagg catcgtgagc gagcgacaag gtgccattct ctccttcgat      780

gacagccccg agtttctcga gttcgccggc agccacgacg cgccgtcgct ttcgcaggtc      840

ggtgccgcct gtccggatca cctcgttcat accaagcgcc ggccgctgtt tgtggattgg      900

tccccttccg aaggcgtcga cgcgttgaaa gaaaagctga aggcggggct tacggcgtat      960

cgcgacgact acacggccta ttacgaacgg aacgtcgacc tcgacgtgcc catgcacgat     1020

ccatttccac gcatcctcct cattccgggg ctcggcgtga ttggcacagg caagaacaag     1080

aagatggcga acatcgcgct cgatctgtac cgcagagcca tcgaggtcat gcgcggtgcg     1140

acggccatcg gcgagtttgt gtcgctcgac gagaaggagt ccttcgacgt cgaatattgg     1200

ccgctcgagc tctataagct cacacttgcg ccgccggaga aggaattgtc gcgaaaggtg     1260

gcgtacatca ccggcggggc cggcggcatc ggcagcgcga ccgcccgccg tctggcggag     1320

gagggggcgc acgtcgtgat cgccgatctc gctgcggacg ccgcccggcg cctggcggag     1380

gagctgtgtg ccgatcacgg ccccggtacg gccatcggcg tcgcgctcga cgtgacgcag     1440

gaagatgcgg tcgttcgttc catcgaggag gccatcctgg cttacggcgg gatcgatctc     1500

ttcgtctcaa acgcgggcct cgcgagctcg gcgcctgtca ccgagacctc gctcgccgag     1560

tggaacaaga acgtcgcagt gctcggtacg ggttacttcc tgacgtcgcg agaggcgttc     1620

cgcgtgatgg tggagcaggg gcgcggcggc gcggtggtct ttgtgacgtc caaaaacgcg     1680

gtttacgcag ggaaggatgc atcggcgtac agcgccgcga aggcgatgga gaaccacctc     1740

gcgcgctgct tggccgtcga aggcgggcct cacggcattc gggtgaacat cgtcatgccg     1800

gacgcggttc tccaaggatc gaacatttgg aattcggcct ggcgcgagga gcgcgcacgc     1860

gcgtacggca ttgcgccgga ggagcttgaa gactactacc gcaggcgcac cattctcggc     1920

gtcaacatcc taccagaaga cattgcggag gccatcctgt tcttctgctc gccgagatcg     1980

gccaaaacga ccgggtgcat gctcacggtg gatggaggcg tcgccgccgc gtttccgcgg     2040

tga                                                                   2043


<210>   1176
<211>   672
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   1176
Val Glu Glu Leu Val Tyr Arg Ser Asn Leu Ile Gly Ser Asp Arg Thr 
                5                   10                  15      

Val Cys Asn Trp Gly Gly Gly Asn Thr Ser Met Lys Thr Thr Glu Lys 
            20                  25                  30          

Asp Phe Arg Gly Arg Glu Ile Glu Val Met Trp Val Lys Gly Ser Gly 
        35                  40                  45              

Ser Asp Leu Ala Thr Met Lys Ala His Asn Phe Ser Gly Leu Lys Leu 
    50                  55                  60                  

Asp Asp Ile Arg Pro Leu Ile Lys Arg Asp Gln Met Pro Asp Glu Glu 
65                  70                  75                  80  

Met Val Asp Tyr Leu Ser His Cys Met Ile Asp Ser Lys His Pro Arg 
                85                  90                  95      

Pro Ser Ile Glu Thr Leu Leu His Ala Phe Leu Pro Tyr Lys His Val 
            100                 105                 110         

Asp His Thr His Pro Asp Ala Ile Ile Ser Ile Cys Cys Ala Asp Asn 
        115                 120                 125             

Gly Lys Gln Ile Ala Glu Asp Ile Tyr Gly Asn Arg Phe Val Trp Val 
    130                 135                 140                 

Pro Tyr Val Arg Pro Gly Phe Thr Leu Ser Lys Met Ile Ala Glu Gly 
145                 150                 155                 160 

Val Ala Asn Asn Pro His Ala Glu Leu Val Leu Met Glu Lys His Gly 
                165                 170                 175     

Leu Val Thr Trp Gly Glu Thr Ser Glu Thr Cys Tyr Gln Lys Thr Ile 
            180                 185                 190         

Ser Ile Ile Gln Glu Ala Glu Gln Tyr Ile Asn Asp Arg Ile Asn Gln 
        195                 200                 205             

His Glu Val Phe Gly Gly Lys Arg Tyr Gln Pro Leu Pro Glu Asp Lys 
    210                 215                 220                 

Arg Lys Gln Ile Leu Ala Gly Ile Met Pro Val Ile Arg Gly Ala Val 
225                 230                 235                 240 

Ser Glu Glu Lys Lys Met Ile Leu Ser Tyr Asp Asp His Asp Asp Val 
                245                 250                 255     

Leu Glu Phe Val Asn Ser Val Gln Ala Pro Ala Leu Ser Gln Ile Gly 
            260                 265                 270         

Ala Ala Cys Pro Asp His Leu Val His Thr Lys Arg Val Pro Leu Tyr 
        275                 280                 285             

Ile Asp Trp Asn Pro Glu Thr Gln Asp Val His Lys Leu Ala Asp Leu 
    290                 295                 300                 

Ile Lys Ser Gly Val Glu Thr Phe Thr Ser Glu Tyr Gln Ala Tyr Phe 
305                 310                 315                 320 

Thr Arg Asn Gln Gln Asp Gly Asp Gln Ile Phe Glu Ser Ala Pro Arg 
                325                 330                 335     

Val Ile Leu Ile Pro Gly Ile Gly Met Val Asn Thr Gly Lys Ser Tyr 
            340                 345                 350         

Ala Met Ser Lys Val Ser Gly Ala Leu Tyr Arg Arg Ala Ile Ala Val 
        355                 360                 365             

Met Lys Gly Ala Thr Ala Leu Gly Gln Phe Val Ser Leu His Glu Asn 
    370                 375                 380                 

Glu Ser Tyr His Val Glu Tyr Trp Pro Leu Glu Leu Tyr Lys Leu Thr 
385                 390                 395                 400 

Leu Ala Pro Pro Glu Ala Glu Phe Ser Arg Lys Val Ala Leu Ile Thr 
                405                 410                 415     

Gly Gly Ala Gly Gly Ile Gly Ser Ala Ala Cys Arg Arg Phe Ala Ala 
            420                 425                 430         

Glu Gly Gly His Val Ile Val Ala Asp Leu Asn Ile Glu Gly Ala Gln 
        435                 440                 445             

Lys Ile Ala Gly Glu Ile Asn Asp Ala Tyr Gly Lys Gly Arg Ala Met 
    450                 455                 460                 

Ala Val Lys Met Asp Val Thr Lys Glu Glu Asp Val Gln Ser Ala Phe 
465                 470                 475                 480 

Glu Arg Ala Ala Leu Ala Tyr Gly Gly Ile Asp Ile Val Val Asn Asn 
                485                 490                 495     

Ala Gly Leu Ala Thr Ser Ser Pro Phe Asp Glu Thr Ser Leu Lys Glu 
            500                 505                 510         

Trp Asn Leu Asn Met Asn Val Leu Gly Thr Gly Tyr Phe Leu Val Ala 
        515                 520                 525             

Arg Glu Ala Phe Lys Gln Met Lys His Gln Asn Arg Gly Gly Ser Met 
    530                 535                 540                 

Val Phe Val Gly Ser Lys Asn Ser Val Tyr Ala Gly Lys Asn Ala Ser 
545                 550                 555                 560 

Ala Tyr Ser Ser Val Lys Ala Leu Glu Thr His Leu Ala Arg Cys Ile 
                565                 570                 575     

Ala Ala Glu Gly Gly Glu Phe Gly Ile Arg Val Asn Ser Val Leu Pro 
            580                 585                 590         

Asp Ala Val Leu Gln Gly Ser Ala Ile Trp Gly Ser Ser Trp Arg Glu 
        595                 600                 605             

Glu Arg Ala Ala Ala Tyr Gly Ile Glu Pro Asp Gln Leu Glu Glu His 
    610                 615                 620                 

Tyr Arg Lys Arg Thr Ala Leu Leu Val Asn Ile Tyr Pro Glu Asp Ile 
625                 630                 635                 640 

Ala Glu Ala Ile Ala Phe Phe Ala Ser Ser Lys Ala Glu Lys Thr Thr 
                645                 650                 655     

Gly Cys Met Ile Thr Val Asp Gly Gly Val Pro Ala Ala Phe Thr Arg 
            660                 665                 670         

<210>   1177
<211>   672
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1177
Leu Ala Glu Leu Val Tyr Arg Ser Asn Leu Ile Gly Ala Asp Arg Ser 
                5                   10                  15      

Val Cys Asn Trp Gly Gly Gly Asn Thr Ser Met Lys Thr Thr Glu Lys 
            20                  25                  30          

Asp Phe Arg Gly Arg Asp Ile Glu Val Met Trp Val Lys Gly Ser Gly 
        35                  40                  45              

Ser Asp Leu Ala Thr Met Ser Ala Gly Gln Phe Thr Gly Leu Arg Leu 
    50                  55                  60                  

Asp Asp Ile Arg Pro Leu Met Glu Arg Ser Ser Met Thr Asp Glu Glu 
65                  70                  75                  80  

Met Thr Ala Tyr Leu Ser His Cys Met Met Asp Gly Lys His Pro Arg 
                85                  90                  95      

Pro Ser Ile Glu Thr Leu Leu His Ala Phe Leu Pro Phe Pro His Val 
            100                 105                 110         

Asp His Thr His Pro Asp Ala Ile Ile Ser Ile Cys Cys Cys Asp Asn 
        115                 120                 125             

Gly Lys Glu Ile Ala Glu Glu Ile Tyr Gly Ser Arg Phe Val Trp Val 
    130                 135                 140                 

Pro Tyr Val Arg Pro Gly Phe Ala Leu Ser Lys Met Ile Ala Glu Gly 
145                 150                 155                 160 

Val Lys Asn Asn Pro Asn Ala Glu Leu Val Leu Met Glu Lys His Gly 
                165                 170                 175     

Leu Val Thr Trp Gly Glu Thr Ser Lys Glu Ser Tyr Asp Gln Thr Ile 
            180                 185                 190         

Ala Val Ile Arg Glu Ala Glu Ala Tyr Ile Lys Ser Arg Ser Glu Asp 
        195                 200                 205             

His Gln Pro Phe Gly Gly Gln Met Val Glu Pro Leu Ala Pro Glu Glu 
    210                 215                 220                 

Arg Lys Arg Ile Leu Ala Asp Ile Leu Pro Val Ile Arg Gly Ala Val 
225                 230                 235                 240 

Ser Gly Glu Lys Arg Met Leu Val Thr Trp Cys Asp Ala Asp Asp Val 
                245                 250                 255     

Leu Glu Phe Ala Asn Ser Arg Arg Ala Pro Ser Leu Ser Gln Val Gly 
            260                 265                 270         

Ala Ala Cys Pro Asp His Leu Val His Thr Lys Arg Val Pro Ala Tyr 
        275                 280                 285             

Ile Pro Trp Asn Pro Ala Glu Gln Asp Thr Glu Ala Leu Val Asp Arg 
    290                 295                 300                 

Ile Lys Thr Glu Ile Ala Gly Phe Lys Glu Ser Tyr Ala Ala Tyr Phe 
305                 310                 315                 320 

Gln Arg Asn Arg His Glu Gly Asp Glu Met Phe Glu Pro Ala Pro Arg 
                325                 330                 335     

Val Met Leu Ile Pro Gly Ile Gly Met Val Thr Ala Gly Lys Ser Leu 
            340                 345                 350         

Ala Met Ala Lys Val Ser Arg Asp Leu Tyr Arg Arg Ala Ile Ala Val 
        355                 360                 365             

Met Lys Gly Thr Glu Val Leu Gly Asn Phe Val Ser Leu Asn Glu Glu 
    370                 375                 380                 

Glu Ser Tyr Asn Val Glu Tyr Trp Pro Leu Glu Leu Tyr Lys Leu Thr 
385                 390                 395                 400 

Leu Ala Pro Pro Glu Ala Glu Phe Ser Arg Lys Ile Ala Phe Val Thr 
                405                 410                 415     

Gly Gly Ala Gly Gly Ile Gly Ser Glu Ala Cys Arg Arg Leu Ala Leu 
            420                 425                 430         

Glu Gly Ala His Val Val Val Ala Asp Ile Asn Ile Glu Gly Ala Glu 
        435                 440                 445             

Lys Thr Ala Ala Glu Ile Asn Asp Gln Tyr Gly Ala Glu Arg Ala Tyr 
    450                 455                 460                 

Ala Val Arg Met Asp Val Thr Lys Glu Glu Glu Val Gln Thr Ala Phe 
465                 470                 475                 480 

Glu Glu Ile Ala Leu Lys Tyr Gly Gly Ile Asp Ile Leu Val Asn Asn 
                485                 490                 495     

Ala Gly Leu Ala Thr Ser Ser Pro Leu Asp Glu Thr Thr Leu Glu Glu 
            500                 505                 510         

Trp Asn Leu Asn Met Asn Val Leu Gly Thr Gly Tyr Phe Leu Val Ala 
        515                 520                 525             

Arg Glu Ala Phe Lys Gln Met Lys Lys Gln Gly Ser Gly Gly Ser Met 
    530                 535                 540                 

Val Phe Val Gly Ser Lys Asn Ser Val Tyr Ala Gly Lys Asn Ala Ser 
545                 550                 555                 560 

Ala Tyr Ser Ser Ala Lys Ala Leu Glu Val His Leu Ala Arg Cys Ile 
                565                 570                 575     

Ala Ala Glu Gly Gly Pro Tyr Gly Ile Arg Ala Asn Ser Val Leu Pro 
            580                 585                 590         

Asp Ala Val Leu Gln Gly Ser Ala Ile Trp Asp Ser Lys Trp Arg Glu 
        595                 600                 605             

Glu Arg Ala Ala Ala Tyr Gly Ile Glu Pro Asp Arg Leu Glu Glu His 
    610                 615                 620                 

Tyr Arg Lys Arg Thr Ala Leu Ser Val Asn Ile Tyr Pro Ala Asp Ile 
625                 630                 635                 640 

Ala Glu Ala Ile Ala Tyr Phe Ala Ser Glu Lys Thr Ala Lys Thr Thr 
                645                 650                 655     

Gly Cys Met Leu Thr Val Asp Gly Gly Val Pro Ala Ala Phe Ser Arg 
            660                 665                 670         

<210>   1178
<211>   673
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   1178
Leu Asp Glu Leu Val Tyr Arg Ser Asn Leu Ile Gly Ala Asp Arg Ser 
                5                   10                  15      

Val Cys Asn Trp Gly Gly Gly Asn Thr Ser Met Lys Thr Thr Glu Ile 
            20                  25                  30          

Asp Phe Arg Gly Asn Glu Val Asp Val Met Trp Val Lys Gly Ser Gly 
        35                  40                  45              

Ser Asp Leu Ala Thr Met Gly Ala Asn Asn Phe Thr Gly Leu Arg Leu 
    50                  55                  60                  

Asp Asp Val Leu Pro Leu Lys Glu Arg Glu Ala Met Thr Asp Glu Glu 
65                  70                  75                  80  

Met Val Ala Tyr Leu Gly His Cys Leu Ile Asp Pro Arg His Pro Arg 
                85                  90                  95      

Pro Ser Ile Glu Thr Leu Leu His Ala Phe Leu Pro Phe Lys His Val 
            100                 105                 110         

Asp His Thr His Pro Asp Ala Ile Ile Ser Leu Cys Cys Ala Glu Asn 
        115                 120                 125             

Gly Arg Glu Leu Ala Glu Glu Leu Phe Gly Asp Arg Phe Val Trp Val 
    130                 135                 140                 

Pro Tyr Ile Arg Pro Gly Phe Ala Leu Ser Lys Met Ile Ala Glu Gln 
145                 150                 155                 160 

Val Asp Ala Asn Pro Lys Ala Glu Leu Val Leu Met Glu Lys His Gly 
                165                 170                 175     

Leu Val Val Trp Gly Glu Thr Ala Lys Glu Ser Tyr Asp Arg Thr Ile 
            180                 185                 190         

Ser Val Ile Asn Glu Ala Glu Gln Phe Ile Glu Lys Lys Arg Gly Lys 
        195                 200                 205             

Asn Ala Pro Phe Gly Gly Ala Ala Thr Ala Gly Leu Lys Lys Glu Glu 
    210                 215                 220                 

Arg Gln Ala Leu Leu Ala Asn Ile Met Pro Val Leu Arg Gly Ala Val 
225                 230                 235                 240 

Ala His Asn Gly Arg Asn Met Ile Val Thr Tyr Asp Asp Ser Asp Pro 
                245                 250                 255     

Ile Leu Glu Phe Val Asn Ser Lys Glu Ala Lys Glu Leu Ser Gln Ile 
            260                 265                 270         

Gly Ala Ala Cys Pro Asp His Leu Val His Thr Lys Arg Leu Pro Leu 
        275                 280                 285             

Phe Ile Asp Trp Val Pro Asp Ala Ser Asp Glu Glu Gly Leu Lys Gln 
    290                 295                 300                 

Ala Val Leu Asn Gly Ile Ala Ala Tyr Lys Glu Asp Tyr Ile Arg Tyr 
305                 310                 315                 320 

Phe Glu Arg Asn Arg Arg Glu Gly Asp Thr Met Phe Glu Pro Ser Pro 
                325                 330                 335     

Arg Val Leu Leu Ile Pro Gly Ile Gly Leu Ile Ser Ser Gly Lys Ala 
            340                 345                 350         

Val Glu Asn Ala Lys Val Ser Arg Ala Leu Tyr Glu Arg Ala Ile Ala 
        355                 360                 365             

Val Met Arg Gly Thr Asn Ala Leu Gly Ser Phe Val Ser Leu Asn Glu 
    370                 375                 380                 

Ala Glu Ser Tyr Glu Ile Glu Tyr Trp Pro Leu Glu Leu Tyr Lys Leu 
385                 390                 395                 400 

Ser Leu Ala Pro Lys Glu Ala Thr Phe Ser Arg Lys Val Ala Phe Val 
                405                 410                 415     

Thr Gly Gly Ala Gly Gly Ile Gly Ser Glu Thr Ser Arg Gln Phe Ala 
            420                 425                 430         

Ala Gln Gly Ala His Val Val Leu Ala Asp Leu Asn Leu Glu Arg Ala 
        435                 440                 445             

Glu Glu Val Ala Ala Glu Ile Asn Gly Gln Phe Gly Ala Gly Arg Ala 
    450                 455                 460                 

Leu Ala Leu Lys Met Asp Val Thr Asp Glu Gln Ala Val Lys Gln Ala 
465                 470                 475                 480 

Phe Ala Asp Val Ala Arg Thr Tyr Gly Gly Val Asp Ile Val Val Asn 
                485                 490                 495     

Asn Ala Gly Leu Ala Thr Ser Ser Pro Phe Asp Glu Thr Thr Leu Gln 
            500                 505                 510         

Glu Trp Gln Leu Asn Leu Asp Val Leu Ala Thr Gly Tyr Phe Leu Val 
        515                 520                 525             

Ala Arg Gln Ala Phe Ala Gln Met Lys Glu Gln Gly Thr Gly Gly Ser 
    530                 535                 540                 

Met Val Phe Ile Gly Ser Lys Asn Ser Val Tyr Ala Gly Lys Asn Ala 
545                 550                 555                 560 

Ser Ala Tyr Ser Ala Ala Lys Ala Met Glu Ala His Leu Ala Arg Cys 
                565                 570                 575     

Ile Ala Ala Glu Gly Gly Thr Tyr Gly Ile Arg Val Asn Thr Val Leu 
            580                 585                 590         

Pro Asp Ala Val Leu Gln Gly Ser Ala Ile Trp Asp Ser Ala Trp Arg 
        595                 600                 605             

Glu Glu Arg Ala Ala Ala Tyr Gly Ile Ala Ala Asp Glu Leu Glu Asp 
    610                 615                 620                 

His Tyr Lys Lys Arg Thr Thr Leu Gly Val His Ile Phe Pro Ala Asp 
625                 630                 635                 640 

Ile Ala Glu Ala Val Leu Phe Phe Ala Ser Ser Lys Ser Glu Lys Thr 
                645                 650                 655     

Thr Gly Cys Met Leu Thr Val Asp Gly Gly Val Pro Ala Ala Phe Pro 
            660                 665                 670         

Arg 
    

<210>   1179
<211>   674
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1179
Thr Gly Leu Asp Glu Leu Val Tyr Arg Ser Asn Leu Ile Gly Ser Asp 
                5                   10                  15      

Arg Ala Val Cys Asn Trp Gly Gly Gly Asn Thr Ser Met Lys Thr Val 
            20                  25                  30          

Glu Lys Asp Phe Arg Gly Arg Glu Ile Ala Val Met Trp Val Lys Gly 
        35                  40                  45              

Ser Gly Ser Asp Leu Ala Thr Met Gly Ala Lys Asn Phe Thr Gly Leu 
    50                  55                  60                  

Asn Leu Glu Asp Ile Arg Pro Leu Ile Glu Arg Glu Glu Met Ser Asp 
65                  70                  75                  80  

Glu Glu Met Val Glu Tyr Leu Gly His Cys Met Ile Asp Arg Asn His 
                85                  90                  95      

Pro Arg Pro Ser Ile Glu Thr Leu Leu His Ala Phe Leu Pro Phe Lys 
            100                 105                 110         

His Val Asp His Thr His Pro Asp Ala Ile Ile Ser Ile Cys Cys Ala 
        115                 120                 125             

Asp Asn Gly Lys Glu Ile Ala Lys Asn Leu Phe Gly Asp Arg Phe Val 
    130                 135                 140                 

Trp Val Pro Tyr Val Arg Pro Gly Phe Ser Leu Ser Lys Leu Ile Ala 
145                 150                 155                 160 

Glu Gly Val Gln Lys Asn Pro His Ala Glu Leu Val Leu Met Glu Lys 
                165                 170                 175     

His Gly Leu Val Val Trp Gly Glu Thr Ala Lys Glu Ser Tyr Asp Arg 
            180                 185                 190         

Thr Ile Ser Val Ile Asn Glu Ala Glu Ala Tyr Ile Arg Ser Arg Ile 
        195                 200                 205             

Asn Glu Ser Val Ile Phe Gly Gly Gly Lys Tyr Thr Ala Leu Ala Lys 
    210                 215                 220                 

Glu Glu Arg Met Ser Met Leu Ala Asn Val Met Pro Val Ile Arg Gly 
225                 230                 235                 240 

Ala Val Ser Asp Glu Lys Lys Met Ile Val Thr Phe Asp Asp Gly Asp 
                245                 250                 255     

Asp Val Leu Glu Phe Val Asn Ser Val Asp Ala Ala Arg Leu Ser Gln 
            260                 265                 270         

Val Gly Ala Ala Cys Pro Asp His Leu Val His Thr Lys Met Lys Pro 
        275                 280                 285             

Leu Phe Val Lys Trp Asp Pro Ser Met Asn Asp Ile Asn Gln Leu Ile 
    290                 295                 300                 

Ala Ala Ile Lys Asp Gly Ile Ser Ser Phe Lys Glu Glu Tyr Lys Ser 
305                 310                 315                 320 

Tyr Phe Glu Arg Asn Lys Asn Glu Gly Asp Val Met Phe Glu Pro Ala 
                325                 330                 335     

Pro Arg Val Ile Leu Ile Pro Gly Ile Gly Met Val Asn Thr Gly Lys 
            340                 345                 350         

Asn Val Thr Met Ala Arg Val Ser Gly Ala Leu Tyr His Arg Ala Ile 
        355                 360                 365             

Ala Val Met Lys Gly Ala Thr Ala Leu Gly Thr Phe Val Ser Leu Asn 
    370                 375                 380                 

Glu Asn Glu Ser Tyr Asn Ile Glu Tyr Trp Pro Leu Glu Leu Tyr Lys 
385                 390                 395                 400 

Leu Ser Leu Ala Pro Ala Glu Ala Glu Phe Ser Arg Lys Val Ala Phe 
                405                 410                 415     

Val Thr Gly Gly Ala Gly Gly Ile Gly Ser Glu Thr Cys Arg Gln Phe 
            420                 425                 430         

Val Ala Glu Gly Ala His Val Val Val Ala Asp Leu Asn Leu Glu Gly 
        435                 440                 445             

Ala Glu Lys Val Val Ser Glu Ile Asn Glu Gln Tyr Gly Thr Asp Arg 
    450                 455                 460                 

Ala Leu Ala Val Lys Met Asp Val Thr Ser Glu Glu Gln Val Gln Ala 
465                 470                 475                 480 

Ala Phe Lys Gln Ala Ser Leu Thr Tyr Gly Gly Ile Asp Ile Val Val 
                485                 490                 495     

Asn Asn Ala Gly Leu Ala Thr Ser Ser Pro Phe Asp Glu Thr Thr Leu 
            500                 505                 510         

Asp Glu Trp Asn Leu Asn Met Asn Val Leu Gly Thr Gly Tyr Phe Leu 
        515                 520                 525             

Val Ala Arg Glu Ala Phe Lys Gln Met Lys Val Gln Gly Thr Gly Gly 
    530                 535                 540                 

Asn Met Val Phe Ile Gly Ser Lys Asn Ser Val Tyr Ala Gly Lys Asn 
545                 550                 555                 560 

Ala Thr Ala Tyr Ser Ser Ala Lys Ala Leu Glu Thr His Leu Ala Arg 
                565                 570                 575     

Cys Ile Ala Ala Glu Gly Gly Pro Phe Gly Ile Arg Val Asn Ser Val 
            580                 585                 590         

Leu Pro Asp Ala Val Leu Gln Gly Ser Ala Ile Trp Gly Ser Arg Trp 
        595                 600                 605             

Arg Gln Glu Arg Ala Thr Ala Tyr Gly Ile Glu Pro Asp Gln Leu Glu 
    610                 615                 620                 

Glu His Tyr Arg Lys Arg Thr Thr Leu Leu Val Asn Val Tyr Pro Gly 
625                 630                 635                 640 

Asp Ile Ala Ala Ala Ile Leu Phe Phe Ala Ser Ser Lys Ala Glu Lys 
                645                 650                 655     

Thr Thr Gly Cys Met Leu Thr Val Asp Gly Gly Val Pro Ala Ala Phe 
            660                 665                 670         

Thr Arg 
        

<210>   1180
<211>   676
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   1180
Leu Ser Pro Leu Glu Glu Leu Ala Tyr Arg Ser Asn Leu Leu Gly Ser 
                5                   10                  15      

Asp Arg Ala Val Ala Asn Tyr Gly Gly Gly Asn Thr Ser Met Lys Leu 
            20                  25                  30          

Arg Gln Glu Asp His Ala Gly Arg Glu Ile Asp Val Leu Trp Val Lys 
        35                  40                  45              

Gly Ser Gly Ser Asp Leu Ala Thr Ile Arg Pro Glu Gln Phe Thr Gly 
    50                  55                  60                  

Leu Arg Leu Ala Glu Ile Leu Pro Leu Met Glu Arg Asp Ser Met Thr 
65                  70                  75                  80  

Asp Glu Glu Met Val Ser Tyr Leu Ala Arg Cys Gln Leu Ala Pro Asp 
                85                  90                  95      

Met Pro Arg Ser Ser Ile Glu Thr Leu Leu His Ala Phe Ile Pro His 
            100                 105                 110         

Pro His Val Asp His Thr His Pro Asp Ala Val Asn Met Leu Cys Cys 
        115                 120                 125             

Ala Ala Asn Gly Glu Glu Leu Ala Arg Glu Cys Phe Gly Asp Glu Ala 
    130                 135                 140                 

Val Trp Ile Pro Tyr Leu Arg Pro Gly Phe Asp Leu Ser Lys Lys Val 
145                 150                 155                 160 

Ala Ala Ala Val Arg Gly Asn Pro Arg Ala Arg Phe Val Leu Leu Ala 
                165                 170                 175     

Lys His Gly Leu Val Thr Trp Gly Glu Thr Ala Glu Glu Ser Tyr Ala 
            180                 185                 190         

Arg Thr Val Glu Ala Val Asn Arg Ala Ala Glu Phe Val Phe Arg Arg 
        195                 200                 205             

Ala Ser Arg Thr Glu Ala Phe Gly Gly Arg Arg Leu Asp Pro Pro Pro 
    210                 215                 220                 

Glu Glu Glu Arg Arg Arg Leu Leu Ala Ala Val Leu Pro Ala Leu Arg 
225                 230                 235                 240 

Gly Glu Leu Ser Ser Arg Gly Gly Pro Lys Ile Leu Arg Ala Asp Thr 
                245                 250                 255     

Ser Pro Asp Val Thr Gly Phe Val Cys Gly Arg Asp Ser Gly Glu Leu 
            260                 265                 270         

Ser Gln Val Gly Ala Ala Cys Pro Asp His Leu Val His Thr Lys Val 
        275                 280                 285             

Arg Pro Leu Trp Val Asp Phe Asp Pro Ala Ser Glu Gly Val Asp Ala 
    290                 295                 300                 

Leu Glu Arg Arg Leu Arg Glu Gly Val Arg Arg Tyr Arg Glu Arg Tyr 
305                 310                 315                 320 

Glu Glu Tyr Phe Arg Arg Asn Arg Ala Arg Val Gly Arg Gly Asp Glu 
                325                 330                 335     

Gln Met His Asp Pro Asn Pro Arg Val Val Leu Ile Ser Gly Val Gly 
            340                 345                 350         

Leu Val Ala Ala Gly Arg Asp Leu Lys Ala Ala Thr Leu Ala Arg Asp 
        355                 360                 365             

Leu Tyr His Arg Ala Ile Ser Val Ile Arg Gly Ala Ser Ser Val Asp 
    370                 375                 380                 

Arg Phe Val Ser Leu Asp Glu Glu Glu Ser Tyr Arg Val Glu Tyr Trp 
385                 390                 395                 400 

Pro Leu Glu Leu Tyr Lys Leu Thr Leu Ala Pro Pro Pro Lys Glu Leu 
                405                 410                 415     

Ala Gly Arg Val Ala Leu Val Thr Gly Gly Ala Gly Gly Ile Gly Ser 
            420                 425                 430         

Ala Val Ala Glu Arg Leu His Glu Ala Gly Ala Cys Val Val Val Ala 
        435                 440                 445             

Asp Leu Asp Gly Glu Gly Ala Ser Glu Val Ala Ser Arg Leu Gly Pro 
    450                 455                 460                 

Glu Gly Leu Ala Val Arg Ala Asp Val Thr Ser Glu Glu Glu Val Ala 
465                 470                 475                 480 

Arg Ala Phe Arg Ala Ala Ala Leu Ala Tyr Gly Gly Val Asp Val Val 
                485                 490                 495     

Ile Ser Asn Ala Gly Leu Ala Ser Ser Ala Pro Leu Glu Glu Thr Ser 
            500                 505                 510         

Leu Asp Leu Trp Arg Arg Asn His Ala Val Leu Ser Glu Gly Tyr Phe 
        515                 520                 525             

Leu Val Ser Arg Glu Ala Phe Ala Leu Leu Lys Arg Gln Gly Ile Gly 
    530                 535                 540                 

Gly Ser Ile Val Phe Val Gly Ser Lys Asn Ala Leu Ala Ala Gly Arg 
545                 550                 555                 560 

Asn Ala Ala Ala Tyr Ser Ser Ala Lys Ala Ala Glu Leu His Leu Ala 
                565                 570                 575     

Arg Cys Leu Ala Glu Glu Gly Gly Pro His Gly Ile Arg Val Asn Thr 
            580                 585                 590         

Val Asn Pro Asp Ala Val Leu Gln Gly Ser Arg Ile Trp Asp Ser Ala 
        595                 600                 605             

Trp Arg Glu Glu Arg Ala Arg Ala Tyr Gly Ile Glu Pro Gly Glu Leu 
    610                 615                 620                 

Glu Glu Tyr Tyr Arg Asn Arg Thr Ala Leu Lys Thr Asn Val Tyr Pro 
625                 630                 635                 640 

Glu Asp Val Ala Glu Ala Val Leu His Phe Ala Ser Gly Arg Arg Ser 
                645                 650                 655     

Gly Lys Ser Thr Gly Asn Val Leu Asn Val Asp Gly Gly Val Arg Glu 
            660                 665                 670         

Ala Tyr Pro Arg 
        675     

<210>   1181
<211>   680
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1174

<400>   1181
Met Ile Val Thr Gln Glu Ile Thr Ala Leu Gln Gln Leu Val Asp Arg 
                5                   10                  15      

Ser Arg Arg Leu Gly Ala Asp Arg Ser Ile Cys Asn Trp Gly Gly Gly 
            20                  25                  30          

Asn Thr Ser Ala Lys Thr Thr Met Leu Asp His Met Gly Arg Glu Ile 
        35                  40                  45              

Arg Val Met Trp Val Lys Gly Ser Gly Ser Asp Leu Ala Glu Ala Thr 
    50                  55                  60                  

Glu Lys Ser Phe Thr Ala Leu Arg Leu Asp Glu Val Leu Pro Leu Met 
65                  70                  75                  80  

Glu Arg Asp Ala Met Thr Asp Glu Glu Met Val Asp Tyr Leu Ala His 
                85                  90                  95      

Cys Met Val Glu Ala Lys His Pro Arg Ser Ser Ile Glu Thr Leu Leu 
            100                 105                 110         

His Ala Phe Ile Pro His Thr His Val Asp His Thr His Pro Asp Ser 
        115                 120                 125             

Ile Ile Ala Ile Cys Thr Ser Thr Asn Gly Arg Glu Val Ala Lys Glu 
    130                 135                 140                 

Ile Phe Gly Asp Arg Ala Val Trp Val Pro Tyr Leu Arg Pro Gly Phe 
145                 150                 155                 160 

Ala Leu Ser Lys Leu Val Ala Asp Ala Val Arg Ala Asn Pro Gln Cys 
                165                 170                 175     

Glu Cys Val Leu Met Glu Lys His Gly Leu Ile Thr Trp Gly Glu Thr 
            180                 185                 190         

Ser Glu Ala Cys Tyr Ala Asn Thr Val Arg Ile Ile Gly Glu Ala Ala 
        195                 200                 205             

Glu Tyr Leu Glu Ala Lys Gln Arg Gly Arg Val Ala Phe Gly Gly Val 
    210                 215                 220                 

Lys His Pro Ala Leu Pro Gln Glu Glu Arg Arg Arg Ile Ala Val Gln 
225                 230                 235                 240 

Ile Leu Pro Phe Val Arg Gly Ile Val Ser Glu Arg Gln Gly Ala Ile 
                245                 250                 255     

Leu Ser Phe Asp Asp Ser Pro Glu Phe Leu Glu Phe Ala Gly Ser His 
            260                 265                 270         

Asp Ala Pro Ser Leu Ser Gln Val Gly Ala Ala Cys Pro Asp His Leu 
        275                 280                 285             

Val His Thr Lys Arg Arg Pro Leu Phe Val Asp Trp Ser Pro Ser Glu 
    290                 295                 300                 

Gly Val Asp Ala Leu Lys Glu Lys Leu Lys Ala Gly Leu Thr Ala Tyr 
305                 310                 315                 320 

Arg Asp Asp Tyr Thr Ala Tyr Tyr Glu Arg Asn Val Asp Leu Asp Val 
                325                 330                 335     

Pro Met His Asp Pro Phe Pro Arg Ile Leu Leu Ile Pro Gly Leu Gly 
            340                 345                 350         

Val Ile Gly Thr Gly Lys Asn Lys Lys Met Ala Asn Ile Ala Leu Asp 
        355                 360                 365             

Leu Tyr Arg Arg Ala Ile Glu Val Met Arg Gly Ala Thr Ala Ile Gly 
    370                 375                 380                 

Glu Phe Val Ser Leu Asp Glu Lys Glu Ser Phe Asp Val Glu Tyr Trp 
385                 390                 395                 400 

Pro Leu Glu Leu Tyr Lys Leu Thr Leu Ala Pro Pro Glu Lys Glu Leu 
                405                 410                 415     

Ser Arg Lys Val Ala Tyr Ile Thr Gly Gly Ala Gly Gly Ile Gly Ser 
            420                 425                 430         

Ala Thr Ala Arg Arg Leu Ala Glu Glu Gly Ala His Val Val Ile Ala 
        435                 440                 445             

Asp Leu Ala Ala Asp Ala Ala Arg Arg Leu Ala Glu Glu Leu Cys Ala 
    450                 455                 460                 

Asp His Gly Pro Gly Thr Ala Ile Gly Val Ala Leu Asp Val Thr Gln 
465                 470                 475                 480 

Glu Asp Ala Val Val Arg Ser Ile Glu Glu Ala Ile Leu Ala Tyr Gly 
                485                 490                 495     

Gly Ile Asp Leu Phe Val Ser Asn Ala Gly Leu Ala Ser Ser Ala Pro 
            500                 505                 510         

Val Thr Glu Thr Ser Leu Ala Glu Trp Asn Lys Asn Val Ala Val Leu 
        515                 520                 525             

Gly Thr Gly Tyr Phe Leu Thr Ser Arg Glu Ala Phe Arg Val Met Val 
    530                 535                 540                 

Glu Gln Gly Arg Gly Gly Ala Val Val Phe Val Thr Ser Lys Asn Ala 
545                 550                 555                 560 

Val Tyr Ala Gly Lys Asp Ala Ser Ala Tyr Ser Ala Ala Lys Ala Met 
                565                 570                 575     

Glu Asn His Leu Ala Arg Cys Leu Ala Val Glu Gly Gly Pro His Gly 
            580                 585                 590         

Ile Arg Val Asn Ile Val Met Pro Asp Ala Val Leu Gln Gly Ser Asn 
        595                 600                 605             

Ile Trp Asn Ser Ala Trp Arg Glu Glu Arg Ala Arg Ala Tyr Gly Ile 
    610                 615                 620                 

Ala Pro Glu Glu Leu Glu Asp Tyr Tyr Arg Arg Arg Thr Ile Leu Gly 
625                 630                 635                 640 

Val Asn Ile Leu Pro Glu Asp Ile Ala Glu Ala Ile Leu Phe Phe Cys 
                645                 650                 655     

Ser Pro Arg Ser Ala Lys Thr Thr Gly Cys Met Leu Thr Val Asp Gly 
            660                 665                 670         

Gly Val Ala Ala Ala Phe Pro Arg 
        675                 680 

<210>   1182
<211>   680
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1174

<400>   1182
Met Ile Val Thr Gln Glu Ile Thr Ala Leu Gln Gln Leu Val Asp Arg 
                5                   10                  15      

Ser Arg Arg Leu Gly Ala Asp Arg Ser Ile Cys Asn Trp Gly Gly Gly 
            20                  25                  30          

Asn Thr Ser Ala Lys Thr Thr Met Leu Asp His Met Gly Arg Glu Ile 
        35                  40                  45              

Arg Val Met Trp Val Lys Gly Ser Gly Ser Asp Leu Ala Glu Ala Thr 
    50                  55                  60                  

Glu Lys Ser Phe Thr Ala Leu Arg Leu Asp Glu Val Leu Pro Leu Met 
65                  70                  75                  80  

Glu Arg Asp Ala Met Thr Asp Glu Glu Met Val Asp Tyr Leu Ala His 
                85                  90                  95      

Cys Met Val Glu Ala Lys His Pro Arg Ser Ser Ile Glu Thr Leu Leu 
            100                 105                 110         

His Ala Phe Ile Pro His Thr His Val Asp His Thr His Pro Asp Ser 
        115                 120                 125             

Ile Ile Ala Ile Cys Thr Ser Thr Asn Gly Arg Glu Val Ala Lys Glu 
    130                 135                 140                 

Ile Phe Gly Asp Arg Ala Val Trp Val Pro Tyr Leu Arg Pro Gly Phe 
145                 150                 155                 160 

Ala Leu Ser Lys Leu Val Ala Glu Ala Val Arg Ala Asn Pro Gln Cys 
                165                 170                 175     

Glu Cys Val Leu Met Glu Lys His Gly Leu Ile Thr Trp Gly Glu Thr 
            180                 185                 190         

Ser Glu Ala Cys Tyr Ala Asn Thr Val Arg Ile Ile Gly Glu Ala Ala 
        195                 200                 205             

Glu Tyr Leu Glu Ala Lys Gln Arg Gly Arg Val Ala Phe Gly Gly Val 
    210                 215                 220                 

Lys His Pro Ala Leu Pro Gln Glu Glu Arg Arg Arg Ile Ala Val Gln 
225                 230                 235                 240 

Ile Leu Pro Phe Val Arg Gly Ile Val Ser Glu Arg Gln Gly Ala Ile 
                245                 250                 255     

Leu Ser Phe Asp Asp Ser Pro Glu Phe Leu Glu Phe Ala Gly Ser His 
            260                 265                 270         

Asp Ala Pro Ser Leu Ser Gln Val Gly Ala Ala Cys Pro Asp His Leu 
        275                 280                 285             

Val His Thr Lys Arg Arg Pro Leu Phe Val Asp Trp Ser Pro Ser Glu 
    290                 295                 300                 

Gly Val Asp Ala Leu Lys Glu Lys Leu Lys Ala Gly Leu Thr Ala Tyr 
305                 310                 315                 320 

Arg Asp Asp Tyr Thr Ala Tyr Tyr Glu Arg Asn Val Asp Leu Asp Val 
                325                 330                 335     

Pro Met His Asp Pro Phe Pro Arg Ile Leu Leu Ile Pro Gly Leu Gly 
            340                 345                 350         

Val Ile Gly Thr Gly Lys Asn Lys Lys Met Ala Gln Ile Ala Leu Asp 
        355                 360                 365             

Leu Tyr Arg Arg Ala Ile Glu Val Met Arg Gly Ala Thr Ala Ile Gly 
    370                 375                 380                 

Glu Phe Val Ser Leu Asp Glu Lys Glu Ser Phe Asp Val Glu Tyr Trp 
385                 390                 395                 400 

Pro Leu Glu Leu Tyr Lys Leu Thr Leu Ala Pro Pro Glu Lys Glu Leu 
                405                 410                 415     

Ser Arg Lys Val Ala Tyr Ile Thr Gly Gly Ala Gly Gly Ile Gly Ser 
            420                 425                 430         

Ala Thr Ala Arg Arg Leu Ala Glu Glu Gly Ala His Val Val Ile Ala 
        435                 440                 445             

Asp Leu Ala Ala Asp Ala Ala Arg Arg Leu Ala Glu Glu Leu Cys Ala 
    450                 455                 460                 

Asp His Gly Pro Gly Thr Ala Ile Gly Val Ala Leu Asp Val Thr Gln 
465                 470                 475                 480 

Glu Asp Ala Val Val Arg Ser Ile Glu Glu Ala Ile Leu Ala Tyr Gly 
                485                 490                 495     

Gly Ile Asp Leu Phe Val Ser Asn Ala Gly Leu Ala Ser Ser Ala Pro 
            500                 505                 510         

Val Thr Glu Thr Ser Leu Ala Glu Trp Asn Lys Asn Val Ala Val Leu 
        515                 520                 525             

Gly Thr Gly Tyr Phe Leu Thr Ser Arg Glu Ala Phe Arg Val Met Val 
    530                 535                 540                 

Glu Gln Gly Arg Gly Gly Ala Val Val Phe Val Thr Ser Lys Asn Ala 
545                 550                 555                 560 

Val Tyr Ala Gly Lys Asp Ala Ser Ala Tyr Ser Ala Ala Lys Ala Met 
                565                 570                 575     

Glu Asn His Leu Ala Arg Cys Leu Ala Val Glu Gly Gly Pro His Gly 
            580                 585                 590         

Ile Arg Val Asn Ile Val Met Pro Asp Ala Val Leu Gln Gly Ser Asn 
        595                 600                 605             

Ile Trp Asn Ser Ala Trp Arg Glu Glu Arg Ala Arg Ala Tyr Gly Ile 
    610                 615                 620                 

Ala Pro Glu Glu Leu Glu Asp Tyr Tyr Arg Arg Arg Thr Ile Leu Gly 
625                 630                 635                 640 

Val Asn Ile Leu Pro Glu Asp Ile Ala Glu Ala Ile Leu Phe Phe Cys 
                645                 650                 655     

Ser Pro Arg Ser Ala Lys Thr Thr Gly Cys Met Leu Thr Val Asp Gly 
            660                 665                 670         

Gly Val Ala Ala Ala Phe Pro Arg 
        675                 680 

<210>   1183
<211>   680
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1174

<400>   1183
Met Ile Val Thr Gln Glu Ile Thr Ala Leu Gln Gln Leu Val Asp Arg 
                5                   10                  15      

Ser Arg Arg Leu Gly Ala Asp Arg Ser Ile Cys Asn Trp Gly Gly Gly 
            20                  25                  30          

Asn Thr Ser Ala Lys Thr Thr Met Leu Asp His Met Gly Arg Glu Ile 
        35                  40                  45              

Arg Val Met Trp Val Lys Gly Ser Gly Ser Asp Leu Ala Glu Ala Thr 
    50                  55                  60                  

Glu Lys Ser Phe Thr Ala Leu Arg Leu Asp Glu Val Leu Pro Leu Met 
65                  70                  75                  80  

Glu Arg Asp Ala Met Thr Asp Glu Glu Met Val Asp Tyr Leu Ala His 
                85                  90                  95      

Cys Met Val Glu Ala Lys His Pro Arg Ser Ser Ile Glu Thr Leu Leu 
            100                 105                 110         

His Ala Phe Ile Pro His Thr His Val Asp His Thr His Pro Asp Ser 
        115                 120                 125             

Ile Ile Ala Ile Cys Thr Ser Thr Asn Gly Arg Glu Val Ala Lys Glu 
    130                 135                 140                 

Ile Phe Gly Asp Arg Ala Val Trp Val Pro Tyr Leu Arg Pro Gly Phe 
145                 150                 155                 160 

Ala Leu Ser Lys Leu Val Ala Glu Ala Val Arg Ala Asn Pro Gln Cys 
                165                 170                 175     

Glu Cys Val Leu Met Glu Lys His Gly Leu Ile Thr Trp Gly Glu Thr 
            180                 185                 190         

Ser Glu Ala Cys Tyr Ala Asn Thr Val Arg Ile Ile Gly Glu Ala Ala 
        195                 200                 205             

Glu Tyr Leu Glu Ala Lys Gln Arg Gly Arg Val Ala Phe Gly Gly Val 
    210                 215                 220                 

Lys His Pro Ala Leu Pro Gln Glu Glu Arg Arg Arg Ile Ala Val Gln 
225                 230                 235                 240 

Ile Leu Pro Phe Val Arg Gly Ile Val Ser Glu Arg Gln Gly Ala Ile 
                245                 250                 255     

Leu Ser Phe Asp Asp Ser Pro Glu Phe Leu Glu Phe Ala Gly Ser His 
            260                 265                 270         

Asp Ala Pro Ser Leu Ser Gln Val Gly Ala Ala Cys Pro Asp His Leu 
        275                 280                 285             

Val His Thr Lys Arg Arg Pro Leu Phe Val Asp Trp Ser Pro Ser Glu 
    290                 295                 300                 

Gly Val Asp Ala Leu Lys Glu Lys Leu Lys Ala Gly Leu Thr Ala Tyr 
305                 310                 315                 320 

Arg Asp Asp Tyr Thr Ala Tyr Tyr Glu Arg Asn Val Asp Leu Asp Val 
                325                 330                 335     

Pro Met His Asp Pro Phe Pro Arg Ile Leu Leu Ile Pro Gly Leu Gly 
            340                 345                 350         

Val Ile Gly Thr Gly Lys Asn Lys Lys Met Ala Asn Ile Ala Leu Asp 
        355                 360                 365             

Leu Tyr Arg Arg Ala Ile Glu Val Met Arg Gly Ala Thr Ala Ile Gly 
    370                 375                 380                 

Glu Phe Val Ser Leu Asp Glu Lys Glu Ser Phe Asp Val Glu Tyr Trp 
385                 390                 395                 400 

Pro Leu Glu Leu Tyr Lys Leu Thr Leu Ala Pro Pro Glu Lys Glu Leu 
                405                 410                 415     

Ser Arg Lys Val Ala Tyr Ile Thr Gly Gly Ala Gly Gly Ile Gly Ser 
            420                 425                 430         

Ala Thr Ala Arg Arg Leu Ala Glu Glu Gly Ala His Val Val Ile Ala 
        435                 440                 445             

Asp Leu Ala Ala Asp Ala Ala Arg Arg Leu Ala Asp Glu Leu Cys Ala 
    450                 455                 460                 

Asp His Gly Pro Gly Thr Ala Ile Gly Val Ala Leu Asp Val Thr Gln 
465                 470                 475                 480 

Glu Asp Ala Val Val Arg Ser Ile Glu Glu Ala Ile Leu Ala Tyr Gly 
                485                 490                 495     

Gly Ile Asp Leu Phe Val Ser Asn Ala Gly Leu Ala Ser Ser Ala Pro 
            500                 505                 510         

Val Thr Glu Thr Ser Leu Ala Glu Trp Asn Lys Asn Val Ala Val Leu 
        515                 520                 525             

Gly Thr Gly Tyr Phe Leu Thr Ser Arg Glu Ala Phe Arg Val Met Val 
    530                 535                 540                 

Glu Gln Gly Arg Gly Gly Ala Val Val Phe Val Thr Ser Lys Asn Ala 
545                 550                 555                 560 

Val Tyr Ala Gly Lys Asp Ala Ser Ala Tyr Ser Ala Ala Lys Ala Met 
                565                 570                 575     

Glu Asn His Leu Ala Arg Cys Leu Ala Val Glu Gly Gly Pro His Gly 
            580                 585                 590         

Ile Arg Val Asn Ile Val Met Pro Asp Ala Val Leu Gln Gly Ser Asn 
        595                 600                 605             

Ile Trp Asn Ser Ala Trp Arg Glu Glu Arg Ala Arg Ala Tyr Gly Ile 
    610                 615                 620                 

Ala Pro Glu Glu Leu Glu Asp Tyr Tyr Arg Arg Arg Thr Ile Leu Gly 
625                 630                 635                 640 

Val Asn Ile Leu Pro Glu Asp Ile Ala Glu Ala Ile Leu Phe Phe Cys 
                645                 650                 655     

Ser Pro Arg Ser Ala Lys Thr Thr Gly Cys Met Leu Thr Val Asp Gly 
            660                 665                 670         

Gly Val Ala Ala Ala Phe Pro Arg 
        675                 680 

<210>   1184
<211>   680
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1174

<400>   1184
Met Ile Val Thr Gln Glu Ile Thr Ala Leu Gln Gln Leu Val Asp Arg 
                5                   10                  15      

Ser Arg Arg Leu Gly Ala Asp Arg Ser Ile Cys Asn Trp Gly Gly Gly 
            20                  25                  30          

Asn Thr Ser Ala Lys Thr Thr Met Leu Asp His Met Gly Arg Glu Ile 
        35                  40                  45              

Arg Val Met Trp Val Lys Gly Ser Gly Ser Asp Leu Ala Glu Ala Thr 
    50                  55                  60                  

Glu Lys Ser Phe Thr Ala Leu Arg Leu Asp Glu Val Leu Pro Leu Met 
65                  70                  75                  80  

Glu Arg Asp Ala Met Thr Asp Glu Glu Met Val Asp Tyr Leu Ala His 
                85                  90                  95      

Cys Met Val Glu Ala Lys His Pro Arg Ser Ser Ile Glu Thr Leu Leu 
            100                 105                 110         

His Ala Phe Ile Pro His Thr His Val Asp His Thr His Pro Asp Ser 
        115                 120                 125             

Ile Ile Ala Ile Cys Thr Ser Thr Asn Gly Arg Glu Val Ala Lys Glu 
    130                 135                 140                 

Ile Phe Gly Asp Arg Ala Val Trp Val Pro Tyr Leu Arg Pro Gly Phe 
145                 150                 155                 160 

Ala Leu Ser Lys Leu Val Ala Glu Ala Val Arg Ala Asn Pro Gln Cys 
                165                 170                 175     

Glu Cys Val Leu Met Glu Lys His Gly Leu Ile Thr Trp Gly Glu Thr 
            180                 185                 190         

Ser Glu Ala Cys Tyr Ala Asn Thr Val Arg Ile Ile Gly Glu Ala Ala 
        195                 200                 205             

Glu Tyr Leu Glu Ala Lys Gln Arg Gly Arg Val Ala Phe Gly Gly Val 
    210                 215                 220                 

Lys His Pro Ala Leu Pro Gln Glu Glu Arg Arg Arg Ile Ala Val Gln 
225                 230                 235                 240 

Ile Leu Pro Phe Val Arg Gly Ile Val Ser Glu Arg Gln Gly Ala Ile 
                245                 250                 255     

Leu Ser Phe Asp Asp Ser Pro Glu Phe Leu Glu Phe Ala Gly Ser His 
            260                 265                 270         

Asp Ala Pro Ser Leu Ser Gln Val Gly Ala Ala Cys Pro Asp His Leu 
        275                 280                 285             

Val His Thr Lys Arg Arg Pro Leu Phe Val Asp Trp Ser Pro Ser Glu 
    290                 295                 300                 

Gly Val Asp Ala Leu Lys Glu Lys Leu Lys Ala Gly Leu Thr Ala Tyr 
305                 310                 315                 320 

Arg Asp Asp Tyr Thr Ala Tyr Tyr Glu Arg Asn Val Asp Leu Asp Val 
                325                 330                 335     

Pro Met His Asp Pro Phe Pro Arg Ile Leu Leu Ile Pro Gly Leu Gly 
            340                 345                 350         

Val Ile Gly Thr Gly Lys Asn Lys Lys Met Ala Asn Ile Ala Leu Asp 
        355                 360                 365             

Leu Tyr Arg Arg Ala Ile Glu Val Met Arg Gly Ala Thr Ala Ile Gly 
    370                 375                 380                 

Glu Phe Val Ser Leu Asp Glu Lys Glu Ser Phe Asp Val Glu Tyr Trp 
385                 390                 395                 400 

Pro Leu Glu Leu Tyr Lys Leu Thr Leu Ala Pro Pro Glu Lys Glu Leu 
                405                 410                 415     

Ser Arg Lys Val Ala Tyr Ile Thr Gly Gly Ala Gly Gly Ile Gly Ser 
            420                 425                 430         

Ala Thr Ala Arg Arg Leu Ala Glu Glu Gly Ala His Val Val Ile Ala 
        435                 440                 445             

Asp Leu Ala Ala Asp Ala Ala Arg Arg Leu Ala Glu Glu Leu Cys Ala 
    450                 455                 460                 

Glu His Gly Pro Gly Thr Ala Ile Gly Val Ala Leu Asp Val Thr Gln 
465                 470                 475                 480 

Glu Asp Ala Val Val Arg Ser Ile Glu Glu Ala Ile Leu Ala Tyr Gly 
                485                 490                 495     

Gly Ile Asp Leu Phe Val Ser Asn Ala Gly Leu Ala Ser Ser Ala Pro 
            500                 505                 510         

Val Thr Glu Thr Ser Leu Ala Glu Trp Asn Lys Asn Val Ala Val Leu 
        515                 520                 525             

Gly Thr Gly Tyr Phe Leu Thr Ser Arg Glu Ala Phe Arg Val Met Val 
    530                 535                 540                 

Glu Gln Gly Arg Gly Gly Ala Val Val Phe Val Thr Ser Lys Asn Ala 
545                 550                 555                 560 

Val Tyr Ala Gly Lys Asp Ala Ser Ala Tyr Ser Ala Ala Lys Ala Met 
                565                 570                 575     

Glu Asn His Leu Ala Arg Cys Leu Ala Val Glu Gly Gly Pro His Gly 
            580                 585                 590         

Ile Arg Val Asn Ile Val Met Pro Asp Ala Val Leu Gln Gly Ser Asn 
        595                 600                 605             

Ile Trp Asn Ser Ala Trp Arg Glu Glu Arg Ala Arg Ala Tyr Gly Ile 
    610                 615                 620                 

Ala Pro Glu Glu Leu Glu Asp Tyr Tyr Arg Arg Arg Thr Ile Leu Gly 
625                 630                 635                 640 

Val Asn Ile Leu Pro Glu Asp Ile Ala Glu Ala Ile Leu Phe Phe Cys 
                645                 650                 655     

Ser Pro Arg Ser Ala Lys Thr Thr Gly Cys Met Leu Thr Val Asp Gly 
            660                 665                 670         

Gly Val Ala Ala Ala Phe Pro Arg 
        675                 680 

<210>   1185
<211>   680
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1174

<400>   1185
Met Ile Val Thr Gln Glu Ile Thr Ala Leu Gln Gln Leu Val Asp Arg 
                5                   10                  15      

Ser Arg Arg Leu Gly Ala Asp Arg Ser Ile Cys Asn Trp Gly Gly Gly 
            20                  25                  30          

Asn Thr Ser Ala Lys Thr Thr Met Leu Asp His Met Gly Arg Glu Ile 
        35                  40                  45              

Arg Val Met Trp Val Lys Gly Ser Gly Ser Asp Leu Ala Glu Ala Thr 
    50                  55                  60                  

Glu Lys Ser Phe Thr Ala Leu Arg Leu Asp Glu Val Leu Pro Leu Met 
65                  70                  75                  80  

Glu Arg Asp Ala Met Thr Asp Glu Glu Met Val Glu Tyr Leu Ala His 
                85                  90                  95      

Cys Met Val Glu Ala Lys His Pro Arg Ser Ser Ile Glu Thr Leu Leu 
            100                 105                 110         

His Ala Phe Ile Pro His Thr His Val Asp His Thr His Pro Asp Ser 
        115                 120                 125             

Ile Ile Ala Ile Cys Thr Ser Thr Asn Gly Arg Glu Val Ala Lys Glu 
    130                 135                 140                 

Ile Phe Gly Asp Arg Ala Val Trp Val Pro Tyr Leu Arg Pro Gly Phe 
145                 150                 155                 160 

Ala Leu Ser Lys Leu Val Ala Glu Ala Val Arg Ala Asn Pro Gln Cys 
                165                 170                 175     

Glu Cys Val Leu Met Glu Lys His Gly Leu Ile Thr Trp Gly Glu Thr 
            180                 185                 190         

Ser Glu Ala Cys Tyr Ala Asn Thr Val Arg Ile Ile Gly Glu Ala Ala 
        195                 200                 205             

Glu Tyr Leu Glu Ala Lys Gln Arg Gly Arg Val Ala Phe Gly Gly Val 
    210                 215                 220                 

Lys His Pro Ala Leu Pro Gln Glu Glu Arg Arg Arg Ile Ala Val Gln 
225                 230                 235                 240 

Ile Leu Pro Phe Val Arg Gly Ile Val Ser Glu Arg Gln Gly Ala Ile 
                245                 250                 255     

Leu Ser Phe Asp Asp Ser Pro Glu Phe Leu Glu Phe Ala Gly Ser His 
            260                 265                 270         

Asp Ala Pro Ser Leu Ser Gln Val Gly Ala Ala Cys Pro Asp His Leu 
        275                 280                 285             

Val His Thr Lys Arg Arg Pro Leu Phe Val Asp Trp Ser Pro Ser Glu 
    290                 295                 300                 

Gly Val Asp Ala Leu Lys Glu Lys Leu Lys Ala Gly Leu Thr Ala Tyr 
305                 310                 315                 320 

Arg Asp Asp Tyr Thr Ala Tyr Tyr Glu Arg Asn Val Asp Leu Asp Val 
                325                 330                 335     

Pro Met His Asp Pro Phe Pro Arg Ile Leu Leu Ile Pro Gly Leu Gly 
            340                 345                 350         

Val Ile Gly Thr Gly Lys Asn Lys Lys Met Ala Asn Ile Ala Leu Asp 
        355                 360                 365             

Leu Tyr Arg Arg Ala Ile Glu Val Met Arg Gly Ala Thr Ala Ile Gly 
    370                 375                 380                 

Glu Phe Val Ser Leu Asp Glu Lys Glu Ser Phe Asp Val Glu Tyr Trp 
385                 390                 395                 400 

Pro Leu Glu Leu Tyr Lys Leu Thr Leu Ala Pro Pro Glu Lys Glu Leu 
                405                 410                 415     

Ser Arg Lys Val Ala Tyr Ile Thr Gly Gly Ala Gly Gly Ile Gly Ser 
            420                 425                 430         

Ala Thr Ala Arg Arg Leu Ala Glu Glu Gly Ala His Val Val Ile Ala 
        435                 440                 445             

Asp Leu Ala Ala Asp Ala Ala Arg Arg Leu Ala Glu Glu Leu Cys Ala 
    450                 455                 460                 

Asp His Gly Pro Gly Thr Ala Ile Gly Val Ala Leu Asp Val Thr Gln 
465                 470                 475                 480 

Glu Asp Ala Val Val Arg Ser Ile Glu Glu Ala Ile Leu Ala Tyr Gly 
                485                 490                 495     

Gly Ile Asp Leu Phe Val Ser Asn Ala Gly Leu Ala Ser Ser Ala Pro 
            500                 505                 510         

Val Thr Glu Thr Ser Leu Ala Glu Trp Asn Lys Asn Val Ala Val Leu 
        515                 520                 525             

Gly Thr Gly Tyr Phe Leu Thr Ser Arg Glu Ala Phe Arg Val Met Val 
    530                 535                 540                 

Glu Gln Gly Arg Gly Gly Ala Val Val Phe Val Thr Ser Lys Asn Ala 
545                 550                 555                 560 

Val Tyr Ala Gly Lys Asp Ala Ser Ala Tyr Ser Ala Ala Lys Ala Met 
                565                 570                 575     

Glu Asn His Leu Ala Arg Cys Leu Ala Val Glu Gly Gly Pro His Gly 
            580                 585                 590         

Ile Arg Val Asn Ile Val Met Pro Asp Ala Val Leu Gln Gly Ser Asn 
        595                 600                 605             

Ile Trp Asn Ser Ala Trp Arg Glu Glu Arg Ala Arg Ala Tyr Gly Ile 
    610                 615                 620                 

Ala Pro Glu Glu Leu Glu Asp Tyr Tyr Arg Arg Arg Thr Ile Leu Gly 
625                 630                 635                 640 

Val Asn Ile Leu Pro Glu Asp Ile Ala Glu Ala Ile Leu Phe Phe Cys 
                645                 650                 655     

Ser Pro Arg Ser Ala Lys Thr Thr Gly Cys Met Leu Thr Val Asp Gly 
            660                 665                 670         

Gly Val Ala Ala Ala Phe Pro Arg 
        675                 680 

<210>   1186
<211>   2043
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1175

<400>   1186
gtgatcgtca cacaggaaat aaccgctctc cagcaacttg tcgaccgatc tcgccgcctc       60

ggcgcggatc gcagcatatg caattggggt gggggaaaca cgtccgccaa gaccaccatg      120

ctcgatcaca tgggccgcga gatccgcgtc atgtgggtga aaggcagcgg ctccgacctc      180

gccgaggcga cggagaagag cttcaccgcg ctgcgtctgg atgaggtgct gccgctcatg      240

gagcgcgacg cgatgacgga cgaggagatg gtcgactacc tcgcgcactg catggtagag      300

gccaagcatc cgcgatcgtc catcgagaca ctgctccacg ccttcatccc gcacacgcat      360

gtggatcaca cgcacccgga cagcatcatc gccatctgca cgagcacaaa cgggcgcgag      420

gtggcgaagg agatcttcgg cgatcgcgcc gtgtgggtcc cgtatctgcg gccggggttc      480

gcgctgtcca agctggtcgc ggatgccgtg cgggcgaacc cccaatgcga gtgcgtgctg      540

atggagaagc atggtctcat cacctggggc gaaacgtccg aagcatgcta cgccaacacc      600

gtgcgcatca ttggtgaagc tgcggagtac ctcgaagcga aacaacgggg acgcgtggcc      660

ttcggcggtg tgaaacatcc cgcgctgcca caggaagaac ggcgccgcat cgccgtgcag      720

atcctgccgt tcgtccgagg catcgtgagc gagcgacaag gtgccattct ctccttcgat      780

gacagccccg agtttctcga gttcgccggc agccacgacg cgccgtcgct ttcgcaggtc      840

ggtgccgcct gtccggatca cctcgttcat accaagcgcc ggccgctgtt tgtggattgg      900

tccccttccg aaggcgtcga cgcgttgaaa gaaaagctga aggcggggct tacggcgtat      960

cgcgacgact acacggccta ttacgaacgg aacgtcgacc tcgacgtgcc catgcacgat     1020

ccatttccac gcatcctcct cattccgggg ctcggcgtga ttggcacagg caagaacaag     1080

aagatggcga acatcgcgct cgatctgtac cgcagagcca tcgaggtcat gcgcggtgcg     1140

acggccatcg gcgagtttgt gtcgctcgac gagaaggagt ccttcgacgt cgaatattgg     1200

ccgctcgagc tctataagct cacacttgcg ccgccggaga aggaattgtc gcgaaaggtg     1260

gcgtacatca ccggcggggc cggcggcatc ggcagcgcga ccgcccgccg tctggcggag     1320

gagggggcgc acgtcgtgat cgccgatctc gctgcggacg ccgcccggcg cctggcggag     1380

gagctgtgtg ccgatcacgg ccccggtacg gccatcggcg tcgcgctcga cgtgacgcag     1440

gaagatgcgg tcgttcgttc catcgaggag gccatcctgg cttacggcgg gatcgatctc     1500

ttcgtctcaa acgcgggcct cgcgagctcg gcgcctgtca ccgagacctc gctcgccgag     1560

tggaacaaga acgtcgcagt gctcggtacg ggttacttcc tgacgtcgcg agaggcgttc     1620

cgcgtgatgg tggagcaggg gcgcggcggc gcggtggtct ttgtgacgtc caaaaacgcg     1680

gtttacgcag ggaaggatgc atcggcgtac agcgccgcga aggcgatgga gaaccacctc     1740

gcgcgctgct tggccgtcga aggcgggcct cacggcattc gggtgaacat cgtcatgccg     1800

gacgcggttc tccaaggatc gaacatttgg aattcggcct ggcgcgagga gcgcgcacgc     1860

gcgtacggca ttgcgccgga ggagcttgaa gactactacc gcaggcgcac cattctcggc     1920

gtcaacatcc taccagaaga cattgcggag gccatcctgt tcttctgctc gccgagatcg     1980

gccaaaacga ccgggtgcat gctcacggtg gatggaggcg tcgccgccgc gtttccgcgg     2040

tga                                                                   2043


<210>   1187
<211>   2043
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1175

<400>   1187
gtgatcgtca cacaggaaat aaccgctctc cagcaacttg tcgaccgatc tcgccgcctc       60

ggcgcggatc gcagcatatg caattggggt gggggaaaca cgtccgccaa gaccaccatg      120

ctcgatcaca tgggccgcga gatccgcgtc atgtgggtga aaggcagcgg ctccgacctc      180

gccgaggcga cggagaagag cttcaccgcg ctgcgtctgg atgaggtgct gccgctcatg      240

gagcgcgacg cgatgacgga cgaggagatg gtcgactacc tcgcgcactg catggtagag      300

gccaagcatc cgcgatcgtc catcgagaca ctgctccacg ccttcatccc gcacacgcat      360

gtggatcaca cgcacccgga cagcatcatc gccatctgca cgagcacaaa cgggcgcgag      420

gtggcgaagg agatcttcgg cgatcgcgcc gtgtgggtcc cgtatctgcg gccggggttc      480

gcgctgtcca agctggtcgc ggaggccgtg cgggcgaacc cccaatgcga gtgcgtgctg      540

atggagaagc atggtctcat cacctggggc gaaacgtccg aagcatgcta cgccaacacc      600

gtgcgcatca ttggtgaagc tgcggagtac ctcgaagcga aacaacgggg acgcgtggcc      660

ttcggcggtg tgaaacatcc cgcgctgcca caggaagaac ggcgccgcat cgccgtgcag      720

atcctgccgt tcgtccgagg catcgtgagc gagcgacaag gtgccattct ctccttcgat      780

gacagccccg agtttctcga gttcgccggc agccacgacg cgccgtcgct ttcgcaggtc      840

ggtgccgcct gtccggatca cctcgttcat accaagcgcc ggccgctgtt tgtggattgg      900

tccccttccg aaggcgtcga cgcgttgaaa gaaaagctga aggcggggct tacggcgtat      960

cgcgacgact acacggccta ttacgaacgg aacgtcgacc tcgacgtgcc catgcacgat     1020

ccatttccac gcatcctcct cattccgggg ctcggcgtga ttggcacagg caagaacaag     1080

aagatggcgc aaatcgcgct cgatctgtac cgcagagcca tcgaggtcat gcgcggtgcg     1140

acggccatcg gcgagtttgt gtcgctcgac gagaaggagt ccttcgacgt cgaatattgg     1200

ccgctcgagc tctataagct cacacttgcg ccgccggaga aggaattgtc gcgaaaggtg     1260

gcgtacatca ccggcggggc cggcggcatc ggcagcgcga ccgcccgccg tctggcggag     1320

gagggggcgc acgtcgtgat cgccgatctc gctgcggacg ccgcccggcg cctggcggag     1380

gagctgtgtg ccgatcacgg ccccggtacg gccatcggcg tcgcgctcga cgtgacgcag     1440

gaagatgcgg tcgttcgttc catcgaggag gccatcctgg cttacggcgg gatcgatctc     1500

ttcgtctcaa acgcgggcct cgcgagctcg gcgcctgtca ccgagacctc gctcgccgag     1560

tggaacaaga acgtcgcagt gctcggtacg ggttacttcc tgacgtcgcg agaggcgttc     1620

cgcgtgatgg tggagcaggg gcgcggcggc gcggtggtct ttgtgacgtc caaaaacgcg     1680

gtttacgcag ggaaggatgc atcggcgtac agcgccgcga aggcgatgga gaaccacctc     1740

gcgcgctgct tggccgtcga aggcgggcct cacggcattc gggtgaacat cgtcatgccg     1800

gacgcggttc tccaaggatc gaacatttgg aattcggcct ggcgcgagga gcgcgcacgc     1860

gcgtacggca ttgcgccgga ggagcttgaa gactactacc gcaggcgcac cattctcggc     1920

gtcaacatcc taccagaaga cattgcggag gccatcctgt tcttctgctc gccgagatcg     1980

gccaaaacga ccgggtgcat gctcacggtg gatggaggcg tcgccgccgc gtttccgcgg     2040

tga                                                                   2043


<210>   1188
<211>   2043
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1175

<400>   1188
gtgatcgtca cacaggaaat aaccgctctc cagcaacttg tcgaccgatc tcgccgcctc       60

ggcgcggatc gcagcatatg caattggggt gggggaaaca cgtccgccaa gaccaccatg      120

ctcgatcaca tgggccgcga gatccgcgtc atgtgggtga aaggcagcgg ctccgacctc      180

gccgaggcga cggagaagag cttcaccgcg ctgcgtctgg atgaggtgct gccgctcatg      240

gagcgcgacg cgatgacgga cgaggagatg gtcgactacc tcgcgcactg catggtagag      300

gccaagcatc cgcgatcgtc catcgagaca ctgctccacg ccttcatccc gcacacgcat      360

gtggatcaca cgcacccgga cagcatcatc gccatctgca cgagcacaaa cgggcgcgag      420

gtggcgaagg agatcttcgg cgatcgcgcc gtgtgggtcc cgtatctgcg gccggggttc      480

gcgctgtcca agctggtcgc ggaggccgtg cgggcgaacc cccaatgcga gtgcgtgctg      540

atggagaagc atggtctcat cacctggggc gaaacgtccg aagcatgcta cgccaacacc      600

gtgcgcatca ttggtgaagc tgcggagtac ctcgaagcga aacaacgggg acgcgtggcc      660

ttcggcggtg tgaaacatcc cgcgctgcca caggaagaac ggcgccgcat cgccgtgcag      720

atcctgccgt tcgtccgagg catcgtgagc gagcgacaag gtgccattct ctccttcgat      780

gacagccccg agtttctcga gttcgccggc agccacgacg cgccgtcgct ttcgcaggtc      840

ggtgccgcct gtccggatca cctcgttcat accaagcgcc ggccgctgtt tgtggattgg      900

tccccttccg aaggcgtcga cgcgttgaaa gaaaagctga aggcggggct tacggcgtat      960

cgcgacgact acacggccta ttacgaacgg aacgtcgacc tcgacgtgcc catgcacgat     1020

ccatttccac gcatcctcct cattccgggg ctcggcgtga ttggcacagg caagaacaag     1080

aagatggcga acatcgcgct cgatctgtac cgcagagcca tcgaggtcat gcgcggtgcg     1140

acggccatcg gcgagtttgt gtcgctcgac gagaaggagt ccttcgacgt cgaatattgg     1200

ccgctcgagc tctataagct cacacttgcg ccgccggaga aggaattgtc gcgaaaggtg     1260

gcgtacatca ccggcggggc cggcggcatc ggcagcgcga ccgcccgccg tctggcggag     1320

gagggggcgc acgtcgtgat cgccgatctc gctgcggacg ccgcccggcg cctggcggat     1380

gagctgtgtg ccgatcacgg ccccggtacg gccatcggcg tcgcgctcga cgtgacgcag     1440

gaagatgcgg tcgttcgttc catcgaggag gccatcctgg cttacggcgg gatcgatctc     1500

ttcgtctcaa acgcgggcct cgcgagctcg gcgcctgtca ccgagacctc gctcgccgag     1560

tggaacaaga acgtcgcagt gctcggtacg ggttacttcc tgacgtcgcg agaggcgttc     1620

cgcgtgatgg tggagcaggg gcgcggcggc gcggtggtct ttgtgacgtc caaaaacgcg     1680

gtttacgcag ggaaggatgc atcggcgtac agcgccgcga aggcgatgga gaaccacctc     1740

gcgcgctgct tggccgtcga aggcgggcct cacggcattc gggtgaacat cgtcatgccg     1800

gacgcggttc tccaaggatc gaacatttgg aattcggcct ggcgcgagga gcgcgcacgc     1860

gcgtacggca ttgcgccgga ggagcttgaa gactactacc gcaggcgcac cattctcggc     1920

gtcaacatcc taccagaaga cattgcggag gccatcctgt tcttctgctc gccgagatcg     1980

gccaaaacga ccgggtgcat gctcacggtg gatggaggcg tcgccgccgc gtttccgcgg     2040

tga                                                                   2043


<210>   1189
<211>   2043
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1175

<400>   1189
gtgatcgtca cacaggaaat aaccgctctc cagcaacttg tcgaccgatc tcgccgcctc       60

ggcgcggatc gcagcatatg caattggggt gggggaaaca cgtccgccaa gaccaccatg      120

ctcgatcaca tgggccgcga gatccgcgtc atgtgggtga aaggcagcgg ctccgacctc      180

gccgaggcga cggagaagag cttcaccgcg ctgcgtctgg atgaggtgct gccgctcatg      240

gagcgcgacg cgatgacgga cgaggagatg gtcgactacc tcgcgcactg catggtagag      300

gccaagcatc cgcgatcgtc catcgagaca ctgctccacg ccttcatccc gcacacgcat      360

gtggatcaca cgcacccgga cagcatcatc gccatctgca cgagcacaaa cgggcgcgag      420

gtggcgaagg agatcttcgg cgatcgcgcc gtgtgggtcc cgtatctgcg gccggggttc      480

gcgctgtcca agctggtcgc ggaggccgtg cgggcgaacc cccaatgcga gtgcgtgctg      540

atggagaagc atggtctcat cacctggggc gaaacgtccg aagcatgcta cgccaacacc      600

gtgcgcatca ttggtgaagc tgcggagtac ctcgaagcga aacaacgggg acgcgtggcc      660

ttcggcggtg tgaaacatcc cgcgctgcca caggaagaac ggcgccgcat cgccgtgcag      720

atcctgccgt tcgtccgagg catcgtgagc gagcgacaag gtgccattct ctccttcgat      780

gacagccccg agtttctcga gttcgccggc agccacgacg cgccgtcgct ttcgcaggtc      840

ggtgccgcct gtccggatca cctcgttcat accaagcgcc ggccgctgtt tgtggattgg      900

tccccttccg aaggcgtcga cgcgttgaaa gaaaagctga aggcggggct tacggcgtat      960

cgcgacgact acacggccta ttacgaacgg aacgtcgacc tcgacgtgcc catgcacgat     1020

ccatttccac gcatcctcct cattccgggg ctcggcgtga ttggcacagg caagaacaag     1080

aagatggcga acatcgcgct cgatctgtac cgcagagcca tcgaggtcat gcgcggtgcg     1140

acggccatcg gcgagtttgt gtcgctcgac gagaaggagt ccttcgacgt cgaatattgg     1200

ccgctcgagc tctataagct cacacttgcg ccgccggaga aggaattgtc gcgaaaggtg     1260

gcgtacatca ccggcggggc cggcggcatc ggcagcgcga ccgcccgccg tctggcggag     1320

gagggggcgc acgtcgtgat cgccgatctc gctgcggacg ccgcccggcg cctggcggag     1380

gagctgtgtg ccgaacacgg ccccggtacg gccatcggcg tcgcgctcga cgtgacgcag     1440

gaagatgcgg tcgttcgttc catcgaggag gccatcctgg cttacggcgg gatcgatctc     1500

ttcgtctcaa acgcgggcct cgcgagctcg gcgcctgtca ccgagacctc gctcgccgag     1560

tggaacaaga acgtcgcagt gctcggtacg ggttacttcc tgacgtcgcg agaggcgttc     1620

cgcgtgatgg tggagcaggg gcgcggcggc gcggtggtct ttgtgacgtc caaaaacgcg     1680

gtttacgcag ggaaggatgc atcggcgtac agcgccgcga aggcgatgga gaaccacctc     1740

gcgcgctgct tggccgtcga aggcgggcct cacggcattc gggtgaacat cgtcatgccg     1800

gacgcggttc tccaaggatc gaacatttgg aattcggcct ggcgcgagga gcgcgcacgc     1860

gcgtacggca ttgcgccgga ggagcttgaa gactactacc gcaggcgcac cattctcggc     1920

gtcaacatcc taccagaaga cattgcggag gccatcctgt tcttctgctc gccgagatcg     1980

gccaaaacga ccgggtgcat gctcacggtg gatggaggcg tcgccgccgc gtttccgcgg     2040

tga                                                                   2043


<210>   1190
<211>   2043
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1175

<400>   1190
gtgatcgtca cacaggaaat aaccgctctc cagcaacttg tcgaccgatc tcgccgcctc       60

ggcgcggatc gcagcatatg caattggggt gggggaaaca cgtccgccaa gaccaccatg      120

ctcgatcaca tgggccgcga gatccgcgtc atgtgggtga aaggcagcgg ctccgacctc      180

gccgaggcga cggagaagag cttcaccgcg ctgcgtctgg atgaggtgct gccgctcatg      240

gagcgcgacg cgatgacgga cgaggagatg gtcgaatacc tcgcgcactg catggtagag      300

gccaagcatc cgcgatcgtc catcgagaca ctgctccacg ccttcatccc gcacacgcat      360

gtggatcaca cgcacccgga cagcatcatc gccatctgca cgagcacaaa cgggcgcgag      420

gtggcgaagg agatcttcgg cgatcgcgcc gtgtgggtcc cgtatctgcg gccggggttc      480

gcgctgtcca agctggtcgc ggaggccgtg cgggcgaacc cccaatgcga gtgcgtgctg      540

atggagaagc atggtctcat cacctggggc gaaacgtccg aagcatgcta cgccaacacc      600

gtgcgcatca ttggtgaagc tgcggagtac ctcgaagcga aacaacgggg acgcgtggcc      660

ttcggcggtg tgaaacatcc cgcgctgcca caggaagaac ggcgccgcat cgccgtgcag      720

atcctgccgt tcgtccgagg catcgtgagc gagcgacaag gtgccattct ctccttcgat      780

gacagccccg agtttctcga gttcgccggc agccacgacg cgccgtcgct ttcgcaggtc      840

ggtgccgcct gtccggatca cctcgttcat accaagcgcc ggccgctgtt tgtggattgg      900

tccccttccg aaggcgtcga cgcgttgaaa gaaaagctga aggcggggct tacggcgtat      960

cgcgacgact acacggccta ttacgaacgg aacgtcgacc tcgacgtgcc catgcacgat     1020

ccatttccac gcatcctcct cattccgggg ctcggcgtga ttggcacagg caagaacaag     1080

aagatggcga acatcgcgct cgatctgtac cgcagagcca tcgaggtcat gcgcggtgcg     1140

acggccatcg gcgagtttgt gtcgctcgac gagaaggagt ccttcgacgt cgaatattgg     1200

ccgctcgagc tctataagct cacacttgcg ccgccggaga aggaattgtc gcgaaaggtg     1260

gcgtacatca ccggcggggc cggcggcatc ggcagcgcga ccgcccgccg tctggcggag     1320

gagggggcgc acgtcgtgat cgccgatctc gctgcggacg ccgcccggcg cctggcggag     1380

gagctgtgtg ccgatcacgg ccccggtacg gccatcggcg tcgcgctcga cgtgacgcag     1440

gaagatgcgg tcgttcgttc catcgaggag gccatcctgg cttacggcgg gatcgatctc     1500

ttcgtctcaa acgcgggcct cgcgagctcg gcgcctgtca ccgagacctc gctcgccgag     1560

tggaacaaga acgtcgcagt gctcggtacg ggttacttcc tgacgtcgcg agaggcgttc     1620

cgcgtgatgg tggagcaggg gcgcggcggc gcggtggtct ttgtgacgtc caaaaacgcg     1680

gtttacgcag ggaaggatgc atcggcgtac agcgccgcga aggcgatgga gaaccacctc     1740

gcgcgctgct tggccgtcga aggcgggcct cacggcattc gggtgaacat cgtcatgccg     1800

gacgcggttc tccaaggatc gaacatttgg aattcggcct ggcgcgagga gcgcgcacgc     1860

gcgtacggca ttgcgccgga ggagcttgaa gactactacc gcaggcgcac cattctcggc     1920

gtcaacatcc taccagaaga cattgcggag gccatcctgt tcttctgctc gccgagatcg     1980

gccaaaacga ccgggtgcat gctcacggtg gatggaggcg tcgccgccgc gtttccgcgg     2040

tga                                                                   2043


<210>   1191
<211>   383
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1191
Met Phe Ser Tyr Ser Ile Gln Thr His Ile Glu Phe Gly Asp Gly Ala 
                5                   10                  15      

Val Glu His Leu Pro Glu His Leu Val Ala Arg Gly Phe Gly Arg Arg 
            20                  25                  30          

Leu Leu Ile Val Thr Asp Pro Gly Leu Val Arg Ala Gly Val Ala Asp 
        35                  40                  45              

Arg Ile Ala Gly Leu Leu Ser Arg Ala Gly Phe Val Pro Arg Val Phe 
    50                  55                  60                  

Ala Glu Val Arg Pro Asn Pro Asp Glu Thr Val Cys Leu Ala Gly Arg 
65                  70                  75                  80  

Gly Ala Phe Phe Glu His Arg Ala Asp Gly Val Val Ala Val Gly Gly 
                85                  90                  95      

Gly Ser Ser Leu Asp Ala Gly Lys Ala Ile Ala Leu Leu Ala Arg Gln 
            100                 105                 110         

Gly Gly Thr Pro Ser Asp Tyr Ala Leu Asn Arg Arg Pro Tyr Gly Pro 
        115                 120                 125             

Pro Ala Pro Val Cys Ala Val Pro Thr Thr Ala Gly Thr Gly Ser Glu 
    130                 135                 140                 

Val Thr Arg Ser Ala Val Ile Thr Glu Arg Gly Thr His Arg Lys Leu 
145                 150                 155                 160 

Thr Leu Lys His Glu Tyr Leu Arg Pro Pro Leu Ala Val Cys Asp Pro 
                165                 170                 175     

Thr Leu Thr Ala Ser Leu Pro Pro Asp Val Thr Ala His Thr Gly Val 
            180                 185                 190         

Asp Ala Leu Val His Ala Ile Glu Gly Ser Thr Cys Lys Gly Ala His 
        195                 200                 205             

Pro Ile Ala Arg Ala Tyr Ala Arg Glu Ala Leu Gly Leu Ile Tyr Arg 
    210                 215                 220                 

Ala Leu Pro Lys Ala Ile Lys Ala Gly Asp Pro Ala Ser Arg His Asp 
225                 230                 235                 240 

Met Leu Leu Gly Ser Leu Leu Ala Gly Leu Ala Phe Gly Ser Thr Asp 
                245                 250                 255     

Val Ala Ser Val His Cys Leu Ala Glu Ala Leu Gly Ser Leu Tyr Glu 
            260                 265                 270         

Thr Pro His Gly Leu Ala Asn Ala Val Met Leu Leu Pro Thr Leu Arg 
        275                 280                 285             

Tyr Asn Leu Pro Cys Ala Val Glu Pro Tyr Ala Trp Ile Ala Arg Ala 
    290                 295                 300                 

Met Gly Leu Ala Arg Glu Glu Asp Gly Ala Glu Arg Ala Ala Glu Ala 
305                 310                 315                 320 

Leu Leu Ala Gly Leu Arg Thr Trp Leu Glu Ser Leu Asp Ile Pro Lys 
                325                 330                 335     

Leu Arg Asp Leu Pro Gly Val Arg Pro Ser Asp Phe Asp Arg Leu Ala 
            340                 345                 350         

Glu Leu Ala Tyr Glu Asn Thr Ser Thr Pro Ser Asn Pro Arg Pro Met 
        355                 360                 365             

Ala Val Ser Asp Tyr Arg Ala Val Leu Glu Met Ala Tyr Ala Asp 
    370                 375                 380             

<210>   1192
<211>   1152
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1192
atgttctcct actccattca gacgcacatc gaatttggcg acggtgccgt cgaacacctt       60

cccgagcacc tcgtggcgcg agggtttggg cggcggctgc tcatcgtgac ggatccgggg      120

ctggtgcggg ccggtgtggc ggatcgcatc gcgggccttc tctctcgcgc gggctttgtg      180

ccccgggtgt tcgccgaggt tcgacccaat ccggacgaaa ccgtctgcct cgcaggtcga      240

ggcgccttct tcgagcaccg cgcagacggc gtcgtggccg tgggcggcgg cagcagcctg      300

gacgcgggca aggccatcgc gctcctcgcg cgccagggcg gcacgccgag cgactacgcg      360

ctcaacagac ggccatacgg tccgcctgcg cccgtctgcg ccgtgcccac caccgctggg      420

acgggatcgg aggtgacgag atcggccgtc atcacggaac gcgggacaca ccgaaagctc      480

accctgaagc acgagtacct gcgcccaccc ctcgctgtgt gcgatccgac cctgaccgca      540

agcctcccgc ccgacgtgac ggctcacacc ggcgtcgacg cgctcgtgca cgccattgaa      600

gggtcgacgt gcaagggagc gcaccccatc gcgcgggcct acgcgcggga ggcgctcggc      660

ctcatctacc gcgccctccc gaaggccatc aaggcaggcg atccggcctc gcggcacgac      720

atgctgctcg gcagcctgct cgcgggtctc gcgttcggat cgacggatgt ggcctccgtg      780

cactgcttgg ccgaggccct gggcagtctg tacgaaacgc cgcacgggtt ggcgaacgcg      840

gtgatgcttt tgccgacgct tcgttacaac ctcccctgcg cggtggagcc gtacgcctgg      900

atcgcgcggg ccatggggct ggcgcgcgag gaagatggcg ccgagcgcgc ggcggaagcg      960

ctccttgcgg ggcttcggac ttggctcgag agcctcgaca tcccgaaact gcgggatctg     1020

ccgggcgtga ggccgtcgga cttcgaccgg ttggcggagc tcgcgtacga gaacacctcg     1080

acgccgagca atccgcgccc gatggcggtg agcgactacc gcgcggtgct cgagatggcc     1140

tatgcagact ga                                                         1152


<210>   1193
<211>   382
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   1193
Phe Glu Tyr His Cys Gln Thr Asn Ile Met Met Gly Asn Gly Gln Ser 
                5                   10                  15      

Lys Glu Ile Gly Ser Ile Val Glu Asp Leu Val Leu Pro Gly Ala Lys 
            20                  25                  30          

Val Met Ile Val Thr Asp Ser Gly Val Arg Asn Ala Gly Leu Val Gln 
        35                  40                  45              

Pro Ile Glu Ala Tyr Leu Gln Glu Ala Gly Tyr Ser Val Phe Val Phe 
    50                  55                  60                  

Asp Gln Val Ser Pro Asn Pro Arg Asp Asn Glu Cys Leu Ala Gly Ala 
65                  70                  75                  80  

Glu Leu Phe Arg Lys Glu Gln Ala Ser Ala Val Ile Ala Ile Gly Gly 
                85                  90                  95      

Gly Ser Pro Met Asp Thr Ala Lys Ala Ile Ala Leu Leu Gly Pro Asn 
            100                 105                 110         

Gly Gly Ile Pro Glu Asp Tyr Lys Ser Gly Lys Lys Ala Tyr Ala Asn 
        115                 120                 125             

Leu Ser Pro Leu Ile Cys Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu 
    130                 135                 140                 

Val Thr Arg Ser Ser Val Ile Thr Leu Ala Ala Ser His Lys Lys Ile 
145                 150                 155                 160 

Thr Leu Lys His Ala Leu Leu Arg Pro Thr Ile Ala Ile Leu Asp Pro 
                165                 170                 175     

Ala Leu Thr Leu Thr Val Pro Lys Ser Ile Thr Ala Ala Thr Gly Val 
            180                 185                 190         

Asp Ala Leu Val His Ala Ile Glu Gly Tyr Ser Cys Lys Val Thr Asn 
        195                 200                 205             

Pro Ile Ser Lys Ala Met Gly Ala Ser Ala Met Glu Thr Ile Val Lys 
    210                 215                 220                 

Tyr Leu Pro Ala Ala Tyr Lys Asp Gly Ser Asp Leu Glu Ala Arg Tyr 
225                 230                 235                 240 

Lys Met Gln Glu Gly Ser Leu Leu Ala Gly Leu Cys Phe Gly Ser Ala 
                245                 250                 255     

Asp Val Ala Ala Val His Cys Leu Ala Glu Ala Leu Gly Ser Leu Tyr 
            260                 265                 270         

Asp Thr Pro His Gly Ile Ala Asn Ala Val Phe Leu Pro Tyr Val Met 
        275                 280                 285             

Gln Phe Asn Ala Ala Glu Asn Lys Val Leu His Ala Glu Leu Ala Lys 
    290                 295                 300                 

Ile Met Ser Phe Ala Asp Lys Thr Asp Ser Asp Asp Val Ala Ile Gln 
305                 310                 315                 320 

Lys Leu Ile Asp Gly Met Tyr Thr Phe Thr Lys Asn Leu Gly Ile Pro 
                325                 330                 335     

Val Leu Lys Asp Leu Ser Tyr Val Lys Glu Glu Asp Phe Glu Lys Met 
            340                 345                 350         

Ala Glu Leu Ala Glu Gln Asn Gly Ser Thr Ser Ser Asn Val Arg Thr 
        355                 360                 365             

Val Thr Lys Ala Asp Tyr Leu Asp Ile Leu Lys Ala Ala Phe 
    370                 375                 380         

<210>   1194
<211>   379
<212>   PRT
<213>   Clostridium bartlettii DSM 16795

<400>   1194
Leu Phe Ser Phe Glu Leu Pro Thr Lys Ile Ile Tyr Gly Ala Asn Cys 
                5                   10                  15      

Leu Asp Asn Leu Cys Val Glu Leu Lys Glu Asn Lys Gly Lys Lys Pro 
            20                  25                  30          

Ile Ile Ile Thr Asp Lys Gly Val Glu Asn Ala Gly Ile Leu Lys Lys 
        35                  40                  45              

Ile Thr Asp Leu Leu Asp Lys Asp Asp Phe Pro Tyr Val Ile Tyr Ala 
    50                  55                  60                  

Gly Val Glu Ala Asn Pro Lys Asp Val Asn Val Glu Glu Gly Ala Lys 
65                  70                  75                  80  

Ile Ala Arg Glu Asn Asp Cys Asp Cys Ile Ile Ala Val Gly Gly Gly 
                85                  90                  95      

Ser Pro Ile Asp Cys Ala Lys Ser Val Gly Val Leu Leu Ala His Asn 
            100                 105                 110         

Asp Thr Glu Ile Lys Lys Tyr Glu Gly Lys Thr Ala Ala Thr Lys Pro 
        115                 120                 125             

Leu Pro Leu Phe Ile Thr Ile Pro Thr Thr Ser Gly Thr Gly Ser Glu 
    130                 135                 140                 

Ile Thr Phe Ser Ser Val Ile Thr Asp Thr Lys Asn Lys Tyr Lys Met 
145                 150                 155                 160 

Thr Val Lys Ser Lys Tyr Thr Ala Ala Lys Val Ala Ile Cys Asp Pro 
                165                 170                 175     

Val Leu Thr Leu Ser Val Pro Pro Ala Val Thr Ala Ala Thr Gly Met 
            180                 185                 190         

Asp Ala Leu Thr His Ala Ile Glu Ala Tyr Thr Ala Thr Cys Ser Glu 
        195                 200                 205             

Pro Ile Ala Asp Ala Val Ser Leu Tyr Ala Ile Glu Leu Ile Tyr Asn 
    210                 215                 220                 

Asn Leu Lys Thr Ala Val Phe Glu Gly Asp Asn Leu Gln Ala Arg Ser 
225                 230                 235                 240 

Ala Met Leu Met Gly Ser Met Leu Ala Gly Ile Gly Phe Ser His Ser 
                245                 250                 255     

Asp Val Ala Ser Val His Cys Ile Ser Glu Ala Leu Gly Gly Met Phe 
            260                 265                 270         

Asp Leu Ser His Gly Val Cys Asn Ala Val Leu Leu Pro His Val Met 
        275                 280                 285             

Glu Tyr Asn Lys Asp Tyr Cys Val Ala Lys Tyr Ala Arg Val Ala Lys 
    290                 295                 300                 

Ala Met Gly Phe Glu Phe Lys Ser Asp Asp Glu Gly Ala Asp Leu Ala 
305                 310                 315                 320 

Val Lys Ala Val Gln Gln Leu Ala Leu Asp Val Lys Leu Pro Leu Phe 
                325                 330                 335     

Ser Glu Leu Asn Val Glu Pro Lys Asp Phe Asp Ile Leu Ala Asp Lys 
            340                 345                 350         

Ser Ala Ile Asn Ile Ser Thr Glu Ser Asn Pro Arg Pro Met Ser Lys 
        355                 360                 365             

Glu Asp Tyr Leu Asn Val Leu Asn Asn Ala Tyr 
    370                 375                 

<210>   1195
<211>   378
<212>   PRT
<213>   Actinobacillus succinogenes 130Z

<400>   1195
Tyr Phe Leu Pro Thr Arg Asn Val Phe Gly Glu Asn Ala Val Glu Glu 
                5                   10                  15      

Val Gly Thr Leu Met Lys Ser Leu Gly Gly Asn Asn Pro Leu Ile Val 
            20                  25                  30          

Thr Asp Ala Phe Leu Ala Lys Asn Gly Met Ala Asp Gln Leu Ala Ala 
        35                  40                  45              

Val Leu Ser Asn Ala Gly Leu Lys Pro Val Ile Phe Gly Gly Ala Glu 
    50                  55                  60                  

Pro Asn Pro Thr Asp Lys Asn Val Glu Glu Gly Ile Val Phe Tyr Asn 
65                  70                  75                  80  

Glu His Gly Cys Asp Ser Ile Ile Ser Leu Gly Gly Gly Ser Ser His 
                85                  90                  95      

Asp Cys Ala Lys Gly Ile Gly Leu Ile Ala Ser Asn Gly Gly Arg Ile 
            100                 105                 110         

Gln Asp Tyr Glu Gly Val Asp Arg Ser His Asn Ala Met Val Pro Leu 
        115                 120                 125             

Met Ala Val Asn Thr Thr Ala Gly Thr Ala Ser Glu Ile Thr Arg Phe 
    130                 135                 140                 

Cys Ile Ile Thr Asp Thr Ala Arg Lys Val Lys Met Ala Ile Val Asp 
145                 150                 155                 160 

Trp Arg Ile Thr Pro Gln Ile Ala Val Asn Asp Pro Leu Leu Met Lys 
                165                 170                 175     

Gly Met Pro Pro Ser Leu Thr Ala Ala Thr Gly Met Asp Ala Leu Thr 
            180                 185                 190         

His Ala Ile Glu Ala Tyr Val Ser Thr Ala Ala Asn Pro Leu Thr Asp 
        195                 200                 205             

Ala Ala Ala Leu Met Ala Ile Thr Met Ile Gln Gln Tyr Leu Pro Lys 
    210                 215                 220                 

Ala Val Ala Asn Gly Asp Tyr Met Lys Ala Arg Asp Lys Met Ala Tyr 
225                 230                 235                 240 

Ala Gln Tyr Leu Ala Gly Ile Ala Phe Asn Asn Ala Ser Leu Gly Tyr 
                245                 250                 255     

Val His Ala Met Ala His Gln Leu Gly Gly Phe Tyr Asn Leu Pro His 
            260                 265                 270         

Gly Val Cys Asn Ala Ile Leu Leu Pro Tyr Val Glu Glu Phe Asn Leu 
        275                 280                 285             

Ile Gly Asn Leu Asn Arg Phe Arg Asp Ile Ala Lys Ala Met Gly Glu 
    290                 295                 300                 

Asn Ile Asp Gly Leu Cys Thr Asp Asp Ala Ala Leu Lys Ala Ile Gly 
305                 310                 315                 320 

Ala Ile Arg Arg Leu Ser Lys Gln Val Gly Ile Pro Ala Asn Leu Gln 
                325                 330                 335     

Leu Leu Gly Val Lys Pro Glu Asp Phe Asp Val Met Ala Glu Asn Ala 
            340                 345                 350         

Met Lys Asp Val Cys Met Leu Thr Asn Pro Arg Lys Ala Thr Lys Gln 
        355                 360                 365             

Gln Val Ile Glu Ile Phe Gln Arg Ala Tyr 
    370                 375             

<210>   1196
<211>   379
<212>   PRT
<213>   Pseudomonas putida KT2440

<400>   1196
Phe Lys Phe Leu Leu Pro Ser Lys Ile Val Met Glu Pro Gly Leu Arg 
                5                   10                  15      

Glu Arg Thr Gly Glu His Leu Arg Gln Leu Gly Leu Ala Arg Val Leu 
            20                  25                  30          

Ile Val Thr Asp Ala Gly Val Lys Ala Ala Gly Leu Leu Asp Ser Val 
        35                  40                  45              

Tyr Ala Ser Leu Asp Lys Ala Gly Ile Ala Tyr Glu Glu Val Ala Asp 
    50                  55                  60                  

Ile Lys Ala Asn Pro Arg Ser Asp Asp Ile Asn His Thr Ala Gln Arg 
65                  70                  75                  80  

Tyr Arg Gly Thr Gly Ile Asp Gly Leu Leu Ala Val Gly Gly Gly Ser 
                85                  90                  95      

Ala Met Asp Ala Ala Lys Ala Ile Ser Leu Leu Leu Thr His Asp Gly 
            100                 105                 110         

Arg Ile Glu Asp Tyr Glu Gly Ser Phe Thr Leu Thr His Ala Ile Pro 
        115                 120                 125             

Pro Ile Val Ala Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Val Thr 
    130                 135                 140                 

Cys Phe Ser Val Ile Thr Asp Thr Ala Arg His Phe Lys Met Asn Val 
145                 150                 155                 160 

Leu Asp Tyr Arg Ile Gly Pro Val Leu Ala Leu Leu Asp Ser His Ile 
                165                 170                 175     

Thr Asp Thr Leu Pro Pro Ser Ile Ala Ala Ala Thr Gly Met Asp Ala 
            180                 185                 190         

Leu Thr His Ala Ile Glu Ala Tyr Thr Cys Arg Val Ala Asn Pro Ile 
        195                 200                 205             

Ser Asp Gly Leu Ala Leu His Ala Ile Arg Leu Ile Ser Gln His Leu 
    210                 215                 220                 

Lys Ala Ala Val Gln Glu Pro Asp Asn Gln Ala Ala Arg Glu Gln Met 
225                 230                 235                 240 

Leu Val Ala Ser Leu Ile Ala Gly Met Ala Phe Gly Asn Ala Asp Val 
                245                 250                 255     

Gly Ser Val His Cys Ile Ser Glu Ala Ile Gly Gly Met Tyr Asp Thr 
            260                 265                 270         

Pro His Gly Val Gly Asn Ala Ile Phe Leu Pro Phe Val Phe Gly His 
        275                 280                 285             

Asn Arg Asp Ala Asp Ile Val Arg His Ala Gln Val Ala Tyr Ala Leu 
    290                 295                 300                 

Gly Ile Asp Pro Thr Leu Ser Pro Val Asp Ala Ala Glu Ala Ala Val 
305                 310                 315                 320 

Gly His Leu Phe Gln Met Ser Lys Asp Leu Gly Ile Pro Arg Phe Ala 
                325                 330                 335     

Glu Val Lys Gly Val Arg Glu Glu Asp Phe Pro Thr Ile Ala Glu Lys 
            340                 345                 350         

Ser Lys Gln Asn Phe Ser Asp Ala Ser Asn Ala Lys Ala Met Ser Val 
        355                 360                 365             

Glu Ala Tyr His Asp Ile Ile Thr Thr Ala Tyr 
    370                 375                 

<210>   1197
<211>   376
<212>   PRT
<213>   Myxococcus xanthus DK 1622

<400>   1197
Thr Arg Ile Val Phe Gly Ala Gly Ala Leu Leu Arg Leu Pro Ala Gln 
                5                   10                  15      

Ala Gln Arg Leu Gly Ile Gln Arg Pro Leu Leu Val Thr Asp Ala Gly 
            20                  25                  30          

Val Val Lys Ala Gly Leu Ala Ala Arg Val Ala Asp Val Leu Asn Thr 
        35                  40                  45              

Ala Gly Leu Ala Cys Glu Val Phe Asp Arg Val Glu Pro Asn Pro Thr 
    50                  55                  60                  

Glu Arg Asp Val Phe Ala Gly Leu Glu Ala Tyr Arg Ser His Ser Cys 
65                  70                  75                  80  

Asp Gly Ile Val Ala Leu Gly Gly Gly Ser Ala Leu Asp Ala Gly Lys 
                85                  90                  95      

Leu Ile Gln Leu Leu Thr Thr His Glu Pro Pro Leu Ser Arg Tyr Asp 
            100                 105                 110         

Asp Ala Lys Gly Gly Asp Gln Tyr Val Arg Asp Asp Leu Pro Pro Leu 
        115                 120                 125             

Ile Ala Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Val Gly Arg Ser 
    130                 135                 140                 

Gly Val Val Thr Leu Glu Asp Thr Gly Arg Lys Thr Val Ile Phe Ser 
145                 150                 155                 160 

Pro Tyr Leu Leu Pro Arg Ala Ala Ile Cys Asp Pro Glu Leu Thr Leu 
                165                 170                 175     

Gly Leu Pro Pro Gly Ile Thr Ala Ala Thr Gly Met Asp Ala Phe Thr 
            180                 185                 190         

His Cys Leu Glu Ala Tyr Leu Ala Asn Gly Phe His Pro Leu Ala Asp 
        195                 200                 205             

Ala Val Ala Ile Asp Gly Ile Tyr Arg Val Gly Arg Ser Leu Glu Thr 
    210                 215                 220                 

Ala Val Arg Asp Gly Lys Asp Leu Ala Ala Arg Thr Asp Met Met Val 
225                 230                 235                 240 

Ala Ala Met Glu Gly Ala Met Ala Phe Gln Lys Gly Leu Gly Ala Cys 
                245                 250                 255     

His Ala Leu Ala His Ala Leu Thr Pro Val Ser Asn Val His His Gly 
            260                 265                 270         

Leu Ala Asn Ala Ile Val Leu Pro Val Val Met Glu Phe Asn Arg Ala 
        275                 280                 285             

Val Cys Thr Ala Arg Leu Ala Arg Val Ala Val Ala Leu Gly Asp Thr 
    290                 295                 300                 

Thr Gln Ala Arg Glu Glu Val Leu Ala Gly Asn Ala Ile Asp Arg Val 
305                 310                 315                 320 

Arg Lys Leu Asn Ala Ala Val Gly Ile Pro Ser Arg Leu Arg Asp Ala 
                325                 330                 335     

Gly Val Gln Glu Lys Asp Leu Glu Arg Ile Ala Glu Lys Ala Phe Gln 
            340                 345                 350         

Asp Ala Ser His Leu Ser Asn Pro Arg Lys Val Ser Gln Ala Asp Leu 
        355                 360                 365             

Leu Ala Leu Ala Arg Glu Ala Tyr 
    370                 375     

<210>   1198
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1191

<400>   1198
Met Phe Ser Tyr Ser Ile Gln Thr His Ile Glu Phe Gly Asp Gly Ala 
                5                   10                  15      

Val Glu His Leu Pro Glu His Leu Val Ala Arg Gly Phe Gly Arg Arg 
            20                  25                  30          

Leu Leu Ile Val Thr Asp Pro Gly Leu Val Arg Ala Gly Val Ala Asp 
        35                  40                  45              

Arg Ile Ala Gly Leu Leu Ser Arg Ala Gly Phe Val Pro Arg Val Phe 
    50                  55                  60                  

Ala Glu Val Arg Pro Asn Pro Asp Glu Thr Val Cys Leu Ala Gly Arg 
65                  70                  75                  80  

Gly Ala Phe Phe Glu His Arg Ala Asp Gly Val Val Ala Val Gly Gly 
                85                  90                  95      

Gly Ser Ser Leu Asp Ala Gly Lys Ala Ile Ala Leu Leu Ala Arg Gln 
            100                 105                 110         

Gly Gly Thr Pro Ser Asp Tyr Ala Leu Asn Arg Arg Pro Tyr Gly Pro 
        115                 120                 125             

Pro Ala Pro Val Cys Ala Val Pro Thr Thr Ala Gly Thr Gly Ser Glu 
    130                 135                 140                 

Val Thr Arg Ser Ala Val Ile Thr Glu Arg Gly Thr His Arg Lys Leu 
145                 150                 155                 160 

Thr Leu Lys His Glu Tyr Leu Arg Pro Pro Leu Ala Val Cys Asp Pro 
                165                 170                 175     

Thr Leu Thr Ala Ser Leu Pro Pro Asp Val Thr Ala His Thr Gly Val 
            180                 185                 190         

Asp Ala Leu Val His Ala Ile Glu Gly Ser Thr Cys Lys Gly Ala His 
        195                 200                 205             

Pro Ile Ala Arg Ala Tyr Ala Arg Glu Ala Leu Gly Leu Ile Tyr Arg 
    210                 215                 220                 

Ala Leu Pro Lys Ala Ile Arg Ala Gly Asp Pro Ala Ser Arg His Asp 
225                 230                 235                 240 

Met Leu Leu Gly Ser Leu Leu Ala Gly Leu Ala Phe Gly Ser Thr Asp 
                245                 250                 255     

Val Ala Ser Val His Cys Leu Ala Glu Ala Leu Gly Ser Leu Tyr Glu 
            260                 265                 270         

Thr Pro His Gly Leu Ala Asn Ala Val Met Leu Leu Pro Thr Leu Arg 
        275                 280                 285             

Tyr Asn Leu Pro Cys Ala Val Glu Pro Tyr Ala Trp Ile Ala Arg Ala 
    290                 295                 300                 

Met Gly Leu Ala Arg Glu Glu Asp Gly Ala Glu Arg Ala Ala Glu Ala 
305                 310                 315                 320 

Leu Leu Ala Gly Leu Arg Thr Trp Leu Glu Ser Leu Asp Ile Pro Lys 
                325                 330                 335     

Leu Arg Asp Leu Pro Gly Val Arg Pro Ser Asp Phe Asp Arg Leu Ala 
            340                 345                 350         

Glu Leu Ala Tyr Glu Asn Thr Ser Thr Pro Ser Asn Pro Arg Pro Met 
        355                 360                 365             

Ala Val Ser Asp Tyr Arg Ala Val Leu Glu Met Ala Tyr Ala Asp 
    370                 375                 380             

<210>   1199
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1191

<400>   1199
Met Phe Ser Tyr Ser Ile Gln Thr His Ile Glu Phe Gly Asp Gly Ala 
                5                   10                  15      

Val Glu His Leu Pro Glu His Leu Val Ala Arg Gly Phe Gly Arg Arg 
            20                  25                  30          

Leu Leu Ile Val Thr Asp Pro Gly Leu Val Arg Ala Gly Val Ala Asp 
        35                  40                  45              

Arg Ile Ala Gly Leu Leu Ser Arg Ala Gly Phe Val Pro Arg Val Phe 
    50                  55                  60                  

Ala Glu Val Arg Pro Asn Pro Asp Glu Thr Val Cys Leu Ala Gly Arg 
65                  70                  75                  80  

Gly Ala Phe Phe Glu His Arg Ala Asp Gly Val Val Ala Val Gly Gly 
                85                  90                  95      

Gly Ser Ser Leu Asp Ala Gly Lys Ala Ile Ala Leu Leu Ala Arg Gln 
            100                 105                 110         

Gly Gly Thr Pro Ser Asp Tyr Ala Leu Asn Arg Arg Pro Tyr Gly Pro 
        115                 120                 125             

Pro Ala Pro Val Cys Ala Val Pro Thr Thr Ala Gly Thr Gly Ser Glu 
    130                 135                 140                 

Val Thr Arg Ser Ala Val Ile Thr Glu Arg Gly Thr His Arg Lys Leu 
145                 150                 155                 160 

Thr Leu Lys His Glu Tyr Leu Arg Pro Pro Leu Ala Val Cys Asp Pro 
                165                 170                 175     

Thr Leu Thr Ala Ser Leu Pro Pro Asp Val Thr Ala His Thr Gly Val 
            180                 185                 190         

Asp Ala Leu Val His Ala Ile Glu Gly Ser Thr Cys Lys Gly Ala His 
        195                 200                 205             

Pro Ile Ala Arg Ala Tyr Ala Arg Glu Ala Leu Gly Leu Ile Tyr Arg 
    210                 215                 220                 

Ala Leu Pro Lys Ala Ile Lys Ala Gly Asp Pro Ala Ser Arg His Asp 
225                 230                 235                 240 

Met Leu Leu Gly Ser Leu Leu Ala Gly Leu Ala Phe Gly Ser Thr Asp 
                245                 250                 255     

Val Ala Ser Val His Cys Leu Ala Glu Ala Leu Gly Ser Leu Tyr Glu 
            260                 265                 270         

Thr Pro His Gly Leu Ala Asn Ala Val Met Leu Leu Pro Thr Leu Arg 
        275                 280                 285             

Tyr Asn Leu Pro Cys Ala Val Glu Pro Tyr Ala Trp Ile Ala Arg Ala 
    290                 295                 300                 

Met Gly Leu Ala Arg Glu Glu Asp Gly Ala Glu Arg Ala Ala Glu Ala 
305                 310                 315                 320 

Leu Leu Ala Gly Leu Arg Thr Trp Leu Glu Ser Leu Asp Ile Pro Lys 
                325                 330                 335     

Leu Arg Glu Leu Pro Gly Val Arg Pro Ser Asp Phe Asp Arg Leu Ala 
            340                 345                 350         

Glu Leu Ala Tyr Glu Asn Thr Ser Thr Pro Ser Asn Pro Arg Pro Met 
        355                 360                 365             

Ala Val Ser Asp Tyr Arg Ala Val Leu Glu Met Ala Tyr Ala Asp 
    370                 375                 380             

<210>   1200
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1191

<400>   1200
Met Phe Ser Tyr Ser Ile Gln Thr His Ile Glu Phe Gly Asp Gly Ala 
                5                   10                  15      

Val Glu His Leu Pro Glu His Leu Val Ala Arg Gly Phe Gly Arg Arg 
            20                  25                  30          

Leu Leu Ile Val Thr Asp Pro Gly Leu Val Arg Ala Gly Val Ala Asp 
        35                  40                  45              

Arg Ile Ala Gly Leu Leu Ser Arg Ala Gly Phe Val Pro Arg Val Phe 
    50                  55                  60                  

Ala Glu Val Arg Pro Asn Pro Asp Glu Thr Val Cys Leu Ala Gly Arg 
65                  70                  75                  80  

Gly Ala Phe Phe Glu His Arg Ala Asp Gly Val Val Ala Val Gly Gly 
                85                  90                  95      

Gly Ser Ser Leu Asp Ala Gly Lys Ala Ile Ala Leu Leu Ala Arg Gln 
            100                 105                 110         

Gly Gly Thr Pro Ser Asp Tyr Ala Leu Asn Arg Arg Pro Tyr Gly Pro 
        115                 120                 125             

Pro Ala Pro Val Cys Ala Val Pro Thr Thr Ala Gly Thr Gly Ser Glu 
    130                 135                 140                 

Val Thr Arg Ser Ala Val Ile Thr Glu Arg Gly Thr His Arg Lys Leu 
145                 150                 155                 160 

Thr Leu Lys His Glu Tyr Leu Arg Pro Pro Leu Ala Val Cys Asp Pro 
                165                 170                 175     

Thr Leu Thr Ala Ser Leu Pro Pro Asp Val Thr Ala His Thr Gly Val 
            180                 185                 190         

Asp Ala Leu Val His Ala Ile Glu Gly Ser Thr Cys Lys Gly Ala His 
        195                 200                 205             

Pro Ile Ala Arg Ala Tyr Ala Arg Glu Ala Leu Gly Leu Ile Tyr Arg 
    210                 215                 220                 

Ala Leu Pro Lys Ala Ile Lys Ala Gly Asp Pro Ala Ser Arg His Asp 
225                 230                 235                 240 

Met Leu Leu Gly Ser Leu Leu Ala Gly Leu Ala Phe Gly Ser Thr Asp 
                245                 250                 255     

Val Ala Ser Val His Cys Leu Ala Glu Ala Leu Gly Ser Leu Tyr Glu 
            260                 265                 270         

Thr Pro His Gly Leu Ala Asn Ala Val Met Leu Leu Pro Thr Leu Arg 
        275                 280                 285             

Tyr Asn Leu Pro Cys Ala Val Glu Pro Tyr Ala Trp Ile Ala Arg Ala 
    290                 295                 300                 

Met Gly Leu Ala Arg Glu Glu Asp Gly Ala Glu Arg Ala Ala Glu Ala 
305                 310                 315                 320 

Ile Leu Ala Gly Leu Arg Thr Trp Leu Glu Ser Leu Asp Ile Pro Lys 
                325                 330                 335     

Leu Arg Asp Leu Pro Gly Val Arg Pro Ser Asp Phe Asp Arg Leu Ala 
            340                 345                 350         

Glu Leu Ala Tyr Glu Asn Thr Ser Thr Pro Ser Asn Pro Arg Pro Met 
        355                 360                 365             

Ala Val Ser Asp Tyr Arg Ala Val Leu Glu Met Ala Tyr Ala Asp 
    370                 375                 380             

<210>   1201
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1191

<400>   1201
Met Phe Ser Tyr Ser Ile Gln Thr His Ile Glu Phe Gly Asp Gly Ala 
                5                   10                  15      

Val Glu His Leu Pro Glu His Leu Val Ala Arg Gly Phe Gly Arg Arg 
            20                  25                  30          

Leu Leu Ile Val Thr Asp Pro Gly Leu Val Arg Ala Gly Val Ala Asp 
        35                  40                  45              

Arg Ile Ala Gly Leu Leu Ser Lys Ala Gly Phe Val Pro Arg Val Phe 
    50                  55                  60                  

Ala Glu Val Arg Pro Asn Pro Asp Glu Thr Val Cys Leu Ala Gly Arg 
65                  70                  75                  80  

Gly Ala Phe Phe Glu His Arg Ala Asp Gly Val Val Ala Val Gly Gly 
                85                  90                  95      

Gly Ser Ser Leu Asp Ala Gly Lys Ala Ile Ala Leu Leu Ala Arg Gln 
            100                 105                 110         

Gly Gly Thr Pro Ser Asp Tyr Ala Leu Asn Arg Arg Pro Tyr Gly Pro 
        115                 120                 125             

Pro Ala Pro Val Cys Ala Val Pro Thr Thr Ala Gly Thr Gly Ser Glu 
    130                 135                 140                 

Val Thr Arg Ser Ala Val Ile Thr Glu Arg Gly Thr His Arg Lys Leu 
145                 150                 155                 160 

Thr Leu Lys His Glu Tyr Leu Arg Pro Pro Leu Ala Val Cys Asp Pro 
                165                 170                 175     

Thr Leu Thr Ala Ser Leu Pro Pro Asp Val Thr Ala His Thr Gly Val 
            180                 185                 190         

Asp Ala Leu Val His Ala Ile Glu Gly Ser Thr Cys Lys Gly Ala His 
        195                 200                 205             

Pro Ile Ala Arg Ala Tyr Ala Arg Glu Ala Leu Gly Leu Ile Tyr Arg 
    210                 215                 220                 

Ala Leu Pro Lys Ala Ile Lys Ala Gly Asp Pro Ala Ser Arg His Asp 
225                 230                 235                 240 

Met Leu Leu Gly Ser Leu Leu Ala Gly Leu Ala Phe Gly Ser Thr Asp 
                245                 250                 255     

Val Ala Ser Val His Cys Leu Ala Glu Ala Leu Gly Ser Leu Tyr Glu 
            260                 265                 270         

Thr Pro His Gly Leu Ala Asn Ala Val Met Leu Leu Pro Thr Leu Arg 
        275                 280                 285             

Tyr Asn Leu Pro Cys Ala Val Glu Pro Tyr Ala Trp Ile Ala Arg Ala 
    290                 295                 300                 

Met Gly Leu Ala Arg Glu Glu Asp Gly Ala Glu Arg Ala Ala Glu Ala 
305                 310                 315                 320 

Leu Leu Ala Gly Leu Arg Thr Trp Leu Glu Ser Leu Asp Ile Pro Lys 
                325                 330                 335     

Leu Arg Asp Leu Pro Gly Val Arg Pro Ser Asp Phe Asp Arg Leu Ala 
            340                 345                 350         

Glu Leu Ala Tyr Glu Asn Thr Ser Thr Pro Ser Asn Pro Arg Pro Met 
        355                 360                 365             

Ala Val Ser Asp Tyr Arg Ala Val Leu Glu Met Ala Tyr Ala Asp 
    370                 375                 380             

<210>   1202
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1191

<400>   1202
Met Phe Ser Tyr Ser Ile Gln Thr His Ile Glu Phe Gly Asp Gly Ala 
                5                   10                  15      

Val Glu His Leu Pro Glu His Leu Val Ala Arg Gly Phe Gly Arg Arg 
            20                  25                  30          

Leu Leu Ile Val Thr Asp Pro Gly Leu Val Arg Ala Gly Val Ala Asp 
        35                  40                  45              

Arg Ile Ala Gly Leu Leu Ser Arg Ala Gly Phe Val Pro Arg Val Phe 
    50                  55                  60                  

Ala Glu Val Arg Pro Asn Pro Asp Glu Thr Val Cys Leu Ala Gly Arg 
65                  70                  75                  80  

Gly Ala Phe Phe Glu His Arg Ala Asp Gly Val Val Ala Val Gly Gly 
                85                  90                  95      

Gly Ser Ser Leu Asp Ala Gly Lys Ala Ile Ala Leu Leu Ala Arg Gln 
            100                 105                 110         

Gly Gly Thr Pro Ser Asp Tyr Ala Leu Asn Arg Arg Pro Tyr Gly Pro 
        115                 120                 125             

Pro Ala Pro Val Cys Ala Val Pro Thr Thr Ala Gly Thr Gly Ser Glu 
    130                 135                 140                 

Val Thr Arg Ser Ala Val Ile Thr Glu Arg Gly Thr His Arg Lys Leu 
145                 150                 155                 160 

Thr Leu Lys His Glu Tyr Leu Arg Pro Pro Leu Ala Val Cys Asp Pro 
                165                 170                 175     

Thr Leu Thr Ala Ser Leu Pro Pro Asp Val Thr Ala His Thr Gly Val 
            180                 185                 190         

Asp Ala Leu Val His Ala Ile Glu Gly Ser Thr Cys Lys Gly Ala His 
        195                 200                 205             

Pro Ile Ala Arg Ala Tyr Ala Arg Glu Ala Leu Gly Leu Ile Tyr Arg 
    210                 215                 220                 

Ala Leu Pro Lys Ala Ile Lys Ala Gly Asp Pro Ala Ser Arg His Asp 
225                 230                 235                 240 

Met Leu Leu Gly Ser Leu Leu Ala Gly Leu Ala Phe Gly Ser Thr Asp 
                245                 250                 255     

Val Ala Ser Val His Cys Leu Ala Glu Ala Leu Gly Ser Leu Tyr Glu 
            260                 265                 270         

Thr Pro His Gly Leu Ala Asn Ala Val Met Leu Leu Pro Thr Leu Arg 
        275                 280                 285             

Tyr Asn Leu Pro Cys Ala Val Glu Pro Tyr Ala Trp Ile Ala Arg Ala 
    290                 295                 300                 

Met Gly Leu Ala Arg Glu Glu Asp Gly Ala Glu Arg Ala Ala Glu Ala 
305                 310                 315                 320 

Leu Leu Ala Gly Leu Arg Thr Trp Leu Glu Ser Leu Asp Ile Pro Lys 
                325                 330                 335     

Leu Arg Asp Ile Pro Gly Val Arg Pro Ser Asp Phe Asp Arg Leu Ala 
            340                 345                 350         

Glu Leu Ala Tyr Glu Asn Thr Ser Thr Pro Ser Asn Pro Arg Pro Met 
        355                 360                 365             

Ala Val Ser Asp Tyr Arg Ala Val Leu Glu Met Ala Tyr Ala Asp 
    370                 375                 380             

<210>   1203
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1192

<400>   1203
atgttctcct actccattca gacgcacatc gaatttggcg acggtgccgt cgaacacctt       60

cccgagcacc tcgtggcgcg agggtttggg cggcggctgc tcatcgtgac ggatccgggg      120

ctggtgcggg ccggtgtggc ggatcgcatc gcgggccttc tctctcgcgc gggctttgtg      180

ccccgggtgt tcgccgaggt tcgacccaat ccggacgaaa ccgtctgcct cgcaggtcga      240

ggcgccttct tcgagcaccg cgcagacggc gtcgtggccg tgggcggcgg cagcagcctg      300

gacgcgggca aggccatcgc gctcctcgcg cgccagggcg gcacgccgag cgactacgcg      360

ctcaacagac ggccatacgg tccgcctgcg cccgtctgcg ccgtgcccac caccgctggg      420

acgggatcgg aggtgacgag atcggccgtc atcacggaac gcgggacaca ccgaaagctc      480

accctgaagc acgagtacct gcgcccaccc ctcgctgtgt gcgatccgac cctgaccgca      540

agcctcccgc ccgacgtgac ggctcacacc ggcgtcgacg cgctcgtgca cgccattgaa      600

gggtcgacgt gcaagggagc gcaccccatc gcgcgggcct acgcgcggga ggcgctcggc      660

ctcatctacc gcgccctccc gaaggccatc cgtgcaggcg atccggcctc gcggcacgac      720

atgctgctcg gcagcctgct cgcgggtctc gcgttcggat cgacggatgt ggcctccgtg      780

cactgcttgg ccgaggccct gggcagtctg tacgaaacgc cgcacgggtt ggcgaacgcg      840

gtgatgcttt tgccgacgct tcgttacaac ctcccctgcg cggtggagcc gtacgcctgg      900

atcgcgcggg ccatggggct ggcgcgcgag gaagatggcg ccgagcgcgc ggcggaagcg      960

ctccttgcgg ggcttcggac ttggctcgag agcctcgaca tcccgaaact gcgggatctg     1020

ccgggcgtga ggccgtcgga cttcgaccgg ttggcggagc tcgcgtacga gaacacctcg     1080

acgccgagca atccgcgccc gatggcggtg agcgactacc gcgcggtgct cgagatggcc     1140

tatgcagact ga                                                         1152


<210>   1204
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1192

<400>   1204
atgttctcct actccattca gacgcacatc gaatttggcg acggtgccgt cgaacacctt       60

cccgagcacc tcgtggcgcg agggtttggg cggcggctgc tcatcgtgac ggatccgggg      120

ctggtgcggg ccggtgtggc ggatcgcatc gcgggccttc tctctcgcgc gggctttgtg      180

ccccgggtgt tcgccgaggt tcgacccaat ccggacgaaa ccgtctgcct cgcaggtcga      240

ggcgccttct tcgagcaccg cgcagacggc gtcgtggccg tgggcggcgg cagcagcctg      300

gacgcgggca aggccatcgc gctcctcgcg cgccagggcg gcacgccgag cgactacgcg      360

ctcaacagac ggccatacgg tccgcctgcg cccgtctgcg ccgtgcccac caccgctggg      420

acgggatcgg aggtgacgag atcggccgtc atcacggaac gcgggacaca ccgaaagctc      480

accctgaagc acgagtacct gcgcccaccc ctcgctgtgt gcgatccgac cctgaccgca      540

agcctcccgc ccgacgtgac ggctcacacc ggcgtcgacg cgctcgtgca cgccattgaa      600

gggtcgacgt gcaagggagc gcaccccatc gcgcgggcct acgcgcggga ggcgctcggc      660

ctcatctacc gcgccctccc gaaggccatc aaggcaggcg atccggcctc gcggcacgac      720

atgctgctcg gcagcctgct cgcgggtctc gcgttcggat cgacggatgt ggcctccgtg      780

cactgcttgg ccgaggccct gggcagtctg tacgaaacgc cgcacgggtt ggcgaacgcg      840

gtgatgcttt tgccgacgct tcgttacaac ctcccctgcg cggtggagcc gtacgcctgg      900

atcgcgcggg ccatggggct ggcgcgcgag gaagatggcg ccgagcgcgc ggcggaagcg      960

ctccttgcgg ggcttcggac ttggctcgag agcctcgaca tcccgaaact gcgggaactg     1020

ccgggcgtga ggccgtcgga cttcgaccgg ttggcggagc tcgcgtacga gaacacctcg     1080

acgccgagca atccgcgccc gatggcggtg agcgactacc gcgcggtgct cgagatggcc     1140

tatgcagact ga                                                         1152


<210>   1205
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1192

<400>   1205
atgttctcct actccattca gacgcacatc gaatttggcg acggtgccgt cgaacacctt       60

cccgagcacc tcgtggcgcg agggtttggg cggcggctgc tcatcgtgac ggatccgggg      120

ctggtgcggg ccggtgtggc ggatcgcatc gcgggccttc tctctcgcgc gggctttgtg      180

ccccgggtgt tcgccgaggt tcgacccaat ccggacgaaa ccgtctgcct cgcaggtcga      240

ggcgccttct tcgagcaccg cgcagacggc gtcgtggccg tgggcggcgg cagcagcctg      300

gacgcgggca aggccatcgc gctcctcgcg cgccagggcg gcacgccgag cgactacgcg      360

ctcaacagac ggccatacgg tccgcctgcg cccgtctgcg ccgtgcccac caccgctggg      420

acgggatcgg aggtgacgag atcggccgtc atcacggaac gcgggacaca ccgaaagctc      480

accctgaagc acgagtacct gcgcccaccc ctcgctgtgt gcgatccgac cctgaccgca      540

agcctcccgc ccgacgtgac ggctcacacc ggcgtcgacg cgctcgtgca cgccattgaa      600

gggtcgacgt gcaagggagc gcaccccatc gcgcgggcct acgcgcggga ggcgctcggc      660

ctcatctacc gcgccctccc gaaggccatc aaggcaggcg atccggcctc gcggcacgac      720

atgctgctcg gcagcctgct cgcgggtctc gcgttcggat cgacggatgt ggcctccgtg      780

cactgcttgg ccgaggccct gggcagtctg tacgaaacgc cgcacgggtt ggcgaacgcg      840

gtgatgcttt tgccgacgct tcgttacaac ctcccctgcg cggtggagcc gtacgcctgg      900

atcgcgcggg ccatggggct ggcgcgcgag gaagatggcg ccgagcgcgc ggcggaagcg      960

attcttgcgg ggcttcggac ttggctcgag agcctcgaca tcccgaaact gcgggatctg     1020

ccgggcgtga ggccgtcgga cttcgaccgg ttggcggagc tcgcgtacga gaacacctcg     1080

acgccgagca atccgcgccc gatggcggtg agcgactacc gcgcggtgct cgagatggcc     1140

tatgcagact ga                                                         1152


<210>   1206
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1192

<400>   1206
atgttctcct actccattca gacgcacatc gaatttggcg acggtgccgt cgaacacctt       60

cccgagcacc tcgtggcgcg agggtttggg cggcggctgc tcatcgtgac ggatccgggg      120

ctggtgcggg ccggtgtggc ggatcgcatc gcgggccttc tctctaaagc gggctttgtg      180

ccccgggtgt tcgccgaggt tcgacccaat ccggacgaaa ccgtctgcct cgcaggtcga      240

ggcgccttct tcgagcaccg cgcagacggc gtcgtggccg tgggcggcgg cagcagcctg      300

gacgcgggca aggccatcgc gctcctcgcg cgccagggcg gcacgccgag cgactacgcg      360

ctcaacagac ggccatacgg tccgcctgcg cccgtctgcg ccgtgcccac caccgctggg      420

acgggatcgg aggtgacgag atcggccgtc atcacggaac gcgggacaca ccgaaagctc      480

accctgaagc acgagtacct gcgcccaccc ctcgctgtgt gcgatccgac cctgaccgca      540

agcctcccgc ccgacgtgac ggctcacacc ggcgtcgacg cgctcgtgca cgccattgaa      600

gggtcgacgt gcaagggagc gcaccccatc gcgcgggcct acgcgcggga ggcgctcggc      660

ctcatctacc gcgccctccc gaaggccatc aaggcaggcg atccggcctc gcggcacgac      720

atgctgctcg gcagcctgct cgcgggtctc gcgttcggat cgacggatgt ggcctccgtg      780

cactgcttgg ccgaggccct gggcagtctg tacgaaacgc cgcacgggtt ggcgaacgcg      840

gtgatgcttt tgccgacgct tcgttacaac ctcccctgcg cggtggagcc gtacgcctgg      900

atcgcgcggg ccatggggct ggcgcgcgag gaagatggcg ccgagcgcgc ggcggaagcg      960

ctccttgcgg ggcttcggac ttggctcgag agcctcgaca tcccgaaact gcgggatctg     1020

ccgggcgtga ggccgtcgga cttcgaccgg ttggcggagc tcgcgtacga gaacacctcg     1080

acgccgagca atccgcgccc gatggcggtg agcgactacc gcgcggtgct cgagatggcc     1140

tatgcagact ga                                                         1152


<210>   1207
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1192

<400>   1207
atgttctcct actccattca gacgcacatc gaatttggcg acggtgccgt cgaacacctt       60

cccgagcacc tcgtggcgcg agggtttggg cggcggctgc tcatcgtgac ggatccgggg      120

ctggtgcggg ccggtgtggc ggatcgcatc gcgggccttc tctctcgcgc gggctttgtg      180

ccccgggtgt tcgccgaggt tcgacccaat ccggacgaaa ccgtctgcct cgcaggtcga      240

ggcgccttct tcgagcaccg cgcagacggc gtcgtggccg tgggcggcgg cagcagcctg      300

gacgcgggca aggccatcgc gctcctcgcg cgccagggcg gcacgccgag cgactacgcg      360

ctcaacagac ggccatacgg tccgcctgcg cccgtctgcg ccgtgcccac caccgctggg      420

acgggatcgg aggtgacgag atcggccgtc atcacggaac gcgggacaca ccgaaagctc      480

accctgaagc acgagtacct gcgcccaccc ctcgctgtgt gcgatccgac cctgaccgca      540

agcctcccgc ccgacgtgac ggctcacacc ggcgtcgacg cgctcgtgca cgccattgaa      600

gggtcgacgt gcaagggagc gcaccccatc gcgcgggcct acgcgcggga ggcgctcggc      660

ctcatctacc gcgccctccc gaaggccatc aaggcaggcg atccggcctc gcggcacgac      720

atgctgctcg gcagcctgct cgcgggtctc gcgttcggat cgacggatgt ggcctccgtg      780

cactgcttgg ccgaggccct gggcagtctg tacgaaacgc cgcacgggtt ggcgaacgcg      840

gtgatgcttt tgccgacgct tcgttacaac ctcccctgcg cggtggagcc gtacgcctgg      900

atcgcgcggg ccatggggct ggcgcgcgag gaagatggcg ccgagcgcgc ggcggaagcg      960

ctccttgcgg ggcttcggac ttggctcgag agcctcgaca tcccgaaact gcgggatatt     1020

ccgggcgtga ggccgtcgga cttcgaccgg ttggcggagc tcgcgtacga gaacacctcg     1080

acgccgagca atccgcgccc gatggcggtg agcgactacc gcgcggtgct cgagatggcc     1140

tatgcagact ga                                                         1152


<210>   1208
<211>   444
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1208
Met Gly Arg Thr Arg Ser Thr Asn Thr Arg Ser Ser Ser Thr Tyr Thr 
                5                   10                  15      

Arg Arg Ser Cys Thr Ser Ser Lys Thr Ala Ile Gly Ile Pro Leu Cys 
            20                  25                  30          

Cys Pro Thr Gly Pro Asp Ala Ile Asp Phe Cys Glu Val Val Arg Arg 
        35                  40                  45              

Met Pro Tyr Ile Arg Ser Gly Phe Gln Phe Met Ala Arg Thr Thr Ile 
    50                  55                  60                  

Thr Asn Gly Val Gly Ser Arg Val Phe Leu Pro Glu Thr Val Arg Gly 
65                  70                  75                  80  

Leu Gly Gly Lys Arg Ala Phe Val Val Thr Asp Pro Gly Ile Val Arg 
                85                  90                  95      

Ala Gly Leu Leu Asp Lys Ile Leu Glu Leu Phe Asp Leu Val Pro Thr 
            100                 105                 110         

Pro Val Thr Ile Ala Gly Val Phe Asp Arg Val Glu Gln Asp Ala Lys 
        115                 120                 125             

Ala His Ile Ile Asn Glu Ala Ala Arg Ala Tyr Arg Glu Cys Ala Ala 
    130                 135                 140                 

Asp Ser Leu Ile Ala Leu Gly Gly Gly Ser Val Leu Asp Thr Val Lys 
145                 150                 155                 160 

Gly Ile Lys Trp Met Val Ser Arg Gly Leu Thr Asp Ile Arg Pro Ala 
                165                 170                 175     

Leu Ile Gly Asn Val Leu Glu Met Trp Pro Glu Ala Gln Pro Ile Phe 
            180                 185                 190         

Ile Pro His Val Ala Leu Pro Thr Thr Ala Gly Thr Gly Ala Glu Ala 
        195                 200                 205             

Ser Pro Ile Ala Val Val Phe His Asp Asp Leu Gly Val Lys Val Asn 
    210                 215                 220                 

Leu Ile Asn Pro Phe Ile Asn Ala Asp Ile Ala Ile Leu Asp Pro Glu 
225                 230                 235                 240 

Leu Thr Val Gly Leu Pro Pro Ser Ile Thr Ala Phe Thr Gly Phe Asp 
                245                 250                 255     

Ala Leu Thr His Ala Ile Glu Gly Phe Phe Ser Pro Gln Ala Asn Pro 
            260                 265                 270         

Phe Thr Asp Ala Tyr Ala Ile Gln Ser Ala Arg Met Ile Phe Glu Asn 
        275                 280                 285             

Leu Pro Lys Ala Val Ala Asn Gly Gln Asp Leu Thr Ala Arg Ala Asn 
    290                 295                 300                 

Met Leu Met Ala Ser Thr Met Ala Ile Ile Ser Phe Ser Leu Ala Leu 
305                 310                 315                 320 

Asn Ala Ile Pro Val His Asn Met Ala His Ala Phe Gly Ala Lys Phe 
                325                 330                 335     

Gly Ile Pro His Gly Leu Ala Asn Ala Val Leu Leu Pro Asn Val Met 
            340                 345                 350         

Ala Ala Met Pro Ala Phe Tyr Arg Ala Arg Ile Arg Glu Phe Met Ala 
        355                 360                 365             

Ala Ile Gly Leu Asp Ala Pro Ser Asp Pro Asp Ala Ala Leu Glu Ser 
    370                 375                 380                 

Phe Ile Gln Arg Ile Arg Asp Leu Arg Gln Gln Val Gly Leu Pro Ala 
385                 390                 395                 400 

Thr Phe Ala Asp Tyr Gln Leu Asp Lys Arg Gln Leu Gly Lys Met Val 
                405                 410                 415     

Asp Leu Val His Ala Asp Pro Ser Gly Val Val Tyr Arg Leu Pro Asp 
            420                 425                 430         

Ala Ile Ile Gln Arg Val Thr Arg Glu Val Ala Ser 
        435                 440                 

<210>   1209
<211>   1335
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1209
ttgggccgta cgcgctcgac gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc       60

acgagctcga aaaccgccat tggtattcca ttgtgttgcc cgacagggcc tgacgcgatc      120

gacttctgcg aggtggtgag gcgcatgccg tacattcgat ctggctttca attcatggcg      180

cgaacgacca tcacaaacgg cgtcggatcg cgcgtgtttt tgccggagac cgtgcgcggg      240

ctcggcggca agcgggcttt tgtggtgacg gacccgggca ttgtccgcgc cggcctcttg      300

gacaagatcc tggagttgtt cgatctcgtg ccgacgcccg tgaccattgc gggcgtgttc      360

gatcgcgtcg agcaggacgc gaaggcacac atcatcaacg aagccgcgcg tgcctaccgc      420

gagtgcgccg cggatagtct catcgccctc ggcggaggca gcgtgctcga cacggtcaag      480

gggatcaagt ggatggtgag ccgtggcctc accgacatcc gcccggcgct catcggcaac      540

gtgctcgaga tgtggcccga ggcgcagccc atcttcattc cgcacgtggc gctgcccacc      600

accgccggaa ccggggcgga ggcctcgccc atcgcggtgg tcttccacga cgatctcggc      660

gtcaaggtga acctcatcaa cccgttcatc aacgccgaca tcgccattct cgatccggaa      720

ctcaccgtcg gcttgccgcc cagcatcacc gccttcaccg gcttcgacgc gctgacgcac      780

gccatcgagg gcttcttctc gccgcaggcc aacccgttca ccgacgcgta cgccatccaa      840

tccgcgcgca tgatcttcga aaacctgccg aaggccgtgg ccaacgggca ggacctgacc      900

gcccgcgcca acatgctgat ggcgagcacg atggccatca tcagcttcag cctggcctta      960

aacgcgattc ccgtccacaa catggcgcac gcgttcggcg cgaagttcgg cattccgcac     1020

ggactcgcga acgcggtgct cctgccgaac gtgatggccg cgatgcccgc gttctatcgc     1080

gcgcgcatcc gcgagttcat ggcggccatc ggcttggacg cgccgtccga tcccgatgcg     1140

gcgctcgaat cgttcattca acgcattcgc gatcttcgtc aacaggtcgg cctgcctgcg     1200

acgttcgccg actaccagct cgacaagcgg cagctcggca agatggtgga tctggtgcac     1260

gccgatccgt ccggcgtcgt ctatcgcctg ccggatgcca tcatccagcg cgtcacgcgc     1320

gaggtggcga gctaa                                                      1335


<210>   1210
<211>   389
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1210
Phe Trp Leu Arg Thr Ala Ile Tyr Thr Gly Ser Asn Thr Arg Ala Leu 
                5                   10                  15      

Val Pro Asp Leu Phe Arg Gly Leu Gly Ala Lys Arg Val Leu Leu Leu 
            20                  25                  30          

Ser Asp Arg Gly Leu Glu Gln Ala Gly Val Val Glu Lys Val Ala Ser 
        35                  40                  45              

Leu Phe Asp Leu Thr Thr His Gly Val Gly Pro Glu Leu Val Gly Ile 
    50                  55                  60                  

Phe Leu Asp Ile Arg Gln Asp Ala Glu Ser Glu Cys Val Asn Glu Ala 
65                  70                  75                  80  

Val Arg Tyr Ala Arg Ala Val Gly Ala Asp Ala Leu Leu Ala Val Gly 
                85                  90                  95      

Gly Gly Ser Val Leu Asp Thr Ala Lys Gly Val Lys Tyr Ala Leu Phe 
            100                 105                 110         

Lys Gly Leu Arg Asp Ile Lys Glu Ala Ile Pro Gly Gly Leu Arg Tyr 
        115                 120                 125             

Glu Ser Phe Pro Gln Ala Gln Phe Met Pro Ile Pro His Ile Ala Ile 
    130                 135                 140                 

Pro Thr Thr Ala Gly Thr Gly Ser Glu Val Ser Pro Ile Ala Val Ile 
145                 150                 155                 160 

Tyr Asn Glu Glu Leu Arg Leu Lys Thr Asn Ile Ile Asn Pro Phe Ile 
                165                 170                 175     

Asn Ala Asp Val Ala Val Leu Asp Pro Asp Leu Thr Val Gly Leu Pro 
            180                 185                 190         

Pro Lys Val Thr Ala Phe Thr Gly Met Asp Ala Leu Thr His Ala Ile 
        195                 200                 205             

Glu Ala Leu Ala Ser Pro Met Ala Thr Ala Leu Thr Asp Ala Cys Ala 
    210                 215                 220                 

Leu Gln Ala Ile Arg Leu Ile Arg Asp Tyr Leu Pro Glu Ala Val Arg 
225                 230                 235                 240 

Asp Gly Gly Asp Ile Arg Ala Arg Leu Glu Met Leu His Ala Ser Leu 
                245                 250                 255     

Leu Gly Ile Thr Ala Phe Ser Phe Ala Leu Asn Ala Ile Pro Val His 
            260                 265                 270         

Asn Phe Ala His Ala Tyr Gly Ala Met Phe Arg Ile Pro His Gly Leu 
        275                 280                 285             

Ala Asn Ala Val Phe Leu Pro Val Val Met Glu Ala Ile Pro Glu Leu 
    290                 295                 300                 

Tyr Leu Pro Lys Ala Lys Leu Leu Ala Gln Ala Leu Gly Ile Tyr Asp 
305                 310                 315                 320 

His Gly Gln Gly Asn Glu Ala Leu Leu Val Lys Ser Ile Glu Arg Ile 
                325                 330                 335     

Arg Gln Leu Arg Asp Asp Ile Gly Leu Pro Ala Asp Phe Ala Asp Tyr 
            340                 345                 350         

Pro Met Thr Glu Glu Gln Phe Ala Ala Thr Ile Pro Ala Val Ala Ser 
        355                 360                 365             

Asp Pro Ala Ala Ile Ser Phe Pro Met Pro Pro Glu Leu Ile Arg Ala 
    370                 375                 380                 

Ile Gly Glu Arg Val 
385                 

<210>   1211
<211>   375
<212>   PRT
<213>   Vibrio shilonii AK1

<400>   1211
Asn Asn Phe Thr Phe Asn Leu Arg Thr Val Val His Ser Gly Ala Ser 
                5                   10                  15      

Ser Ile Glu Ala Ile Pro Thr Leu Phe Lys Ala Lys Gly Ala Gln Arg 
            20                  25                  30          

Val Leu Leu Val Ser Asp Lys Gly Leu Glu Ser Leu Gly Phe Val Glu 
        35                  40                  45              

Arg Leu Ala Ser Leu Phe Ser Thr Glu Glu Lys Val Lys Leu Ala Gly 
    50                  55                  60                  

Ile Tyr Thr Asp Ile Glu Ala Asp Ala Ser Cys Leu Asp Ile Asn Arg 
65                  70                  75                  80  

Ala Leu Glu Phe Ala Lys Gln Val Asn Ala Asp Ser Ile Leu Ala Leu 
                85                  90                  95      

Gly Gly Gly Ser Val Ile Asp Ala Ser Lys Gly Ile Lys Tyr Gly Leu 
            100                 105                 110         

Glu His Lys Leu Asp Asp Ile Arg Asp Ala Ile Gln Gly Gly Gly Arg 
        115                 120                 125             

Leu Glu Val Gly Pro Asp Val Lys Pro Phe Ser Ile Pro His Ile Gly 
    130                 135                 140                 

Val Pro Thr Thr Ala Gly Thr Gly Ala Glu Ala Ser Pro Ile Ala Val 
145                 150                 155                 160 

Phe Tyr Asn Glu Arg Glu Gln Val Lys Ala Ser Leu Val Val Ser Gly 
                165                 170                 175     

Leu Glu Cys Asp Ile Ala Val Leu Asp Pro Glu Leu Thr Val Ser Leu 
            180                 185                 190         

Pro Ala Ala Leu Thr Val Ser Thr Gly Met Asp Ala Leu Thr His Ala 
        195                 200                 205             

Ile Glu Ala Leu Ala Ser Pro Leu Ser Asn Thr Phe Thr Asp Ala Tyr 
    210                 215                 220                 

Ala Thr Gln Ala Cys Arg Leu Ile Leu Asn Asn Leu Pro Gln Val Leu 
225                 230                 235                 240 

Gln Ser Pro Gln Asn Val Ala Ala Arg Cys Glu Leu Leu Gln Ala Ser 
                245                 250                 255     

Thr Met Ala Ile Ser Ala Phe Tyr Ser Ser Leu Gly Gly Ile Pro Ile 
            260                 265                 270         

His Asn Cys Ala His Ala Phe Gly Ala Val Ala His Ile Pro His Gly 
        275                 280                 285             

Asp Ala Asn Ser Val Leu Leu Pro Val Val Ile Glu Ala Leu Pro Glu 
    290                 295                 300                 

Phe Tyr Leu Pro Ser Ile Asn Lys Leu Ala Ala Val Phe Gly Ile Ser 
305                 310                 315                 320 

Pro Ser Leu Thr Asp Ala Glu Lys His Gln Glu Val Val His Ser Leu 
                325                 330                 335     

Arg Ala Phe Gln Ala Leu Val Asn Ala Thr Gln Ser Phe Ala Lys Trp 
            340                 345                 350         

Asn Leu Asp Asp Asn Lys Lys Ala Gln Ile Val Ser Gly Ile Glu Lys 
        355                 360                 365             

Asp Ile Ser Phe Gln Phe Tyr 
    370                 375 

<210>   1212
<211>   393
<212>   PRT
<213>   Vibrio splendidus 12B01

<400>   1212
Asn Asn Phe Asn Phe Gln Leu Lys Thr Ile Val His Ala Gln Glu Asn 
                5                   10                  15      

Gly Ile Glu Asn Ile Pro Ser Leu Phe Gly Arg Leu Gly Ala Gln Arg 
            20                  25                  30          

Val Val Leu Phe Ser Asp Lys Gly Leu Glu Ser Leu Gly Phe Val Glu 
        35                  40                  45              

Gln Phe Ser Ala Leu Phe Val Asn Glu Lys Val Asn Gln Pro Gly Tyr 
    50                  55                  60                  

Glu Gln Ala Val Gln Leu Val Gly Val Tyr Thr Asp Ile Ala Pro Asp 
65                  70                  75                  80  

Ala Thr Cys Asp Asn Ile Asn Ala Ala Ile Glu Phe Ala Asn Ser Val 
                85                  90                  95      

Asn Ala Asp Ala Ile Leu Ser Val Gly Gly Gly Ser Val Ile Asp Ala 
            100                 105                 110         

Ser Lys Gly Val Lys Tyr Ala Phe His Lys Gln Ile Asp Asp Ile Arg 
        115                 120                 125             

Thr Val Ile Ala Gly Gly Gly His Ile Asp Val Trp Pro Asn Asn Glu 
    130                 135                 140                 

Asp Ile Arg Val Pro His Ile Ala Val Pro Thr Thr Ala Gly Thr Gly 
145                 150                 155                 160 

Ala Glu Ala Ser Pro Ile Ala Val Phe Tyr Asn Glu His Glu Asn Ile 
                165                 170                 175     

Lys Ala Ser Leu Val Ala Ser Gly Leu Glu Ala Asp Ile Ala Ile Leu 
            180                 185                 190         

Asp Pro Thr Val Thr Thr Lys Leu Pro Ala His Leu Thr Arg Ser Thr 
        195                 200                 205             

Ala Met Asp Ala Leu Thr His Ala Val Glu Ala Ile Val Ser Pro Met 
    210                 215                 220                 

Ser Asn Ala Phe Thr Asp Ala Tyr Gly Ile Gln Ala Ala Lys Leu Ile 
225                 230                 235                 240 

Ile Glu Asn Leu Pro Leu Ala Leu Lys Glu Pro Glu Asn Leu Thr Ala 
                245                 250                 255     

Arg Gly Asn Leu Leu Gln Ala Ser Thr Met Ala Ile Ser Ala Phe Tyr 
            260                 265                 270         

Ser Ser Leu Gly Gly Ile Pro Ile His Asn Cys Ala His Ala Phe Gly 
        275                 280                 285             

Ala Ile Ser His Ile Pro His Gly Asp Ala Asn Thr Val Leu Val Pro 
    290                 295                 300                 

Val Val Ile Glu Ala Leu Pro Glu Phe Tyr Met Pro Asn Ala Ala Lys 
305                 310                 315                 320 

Leu Ala Gln Ala Phe Ser Val Asp Thr Thr Gly Thr Asp Glu Met Val 
                325                 330                 335     

Tyr Gln Arg Val Leu Asp Phe Leu Asn Asn Phe Gln Thr Ser Val Gly 
            340                 345                 350         

Ala Met Lys Arg Phe Ser Ser Trp Asp Phe Asp Ala Gln Glu Lys Ser 
        355                 360                 365             

Asn Ile Ala Glu Ala Ile Glu Lys Asp Ile Cys Phe Gln Phe Tyr Pro 
    370                 375                 380                 

Ile Ser Lys Gln Thr Ile Glu Thr Ile 
385                 390             

<210>   1213
<211>   381
<212>   PRT
<213>   Roseiflexus sp. RS-1

<400>   1213
Phe Glu Tyr His Met Arg Thr Arg Leu Met Tyr Lys Ile Gly Leu Ala 
                5                   10                  15      

Arg Asp Phe Ala Asn Glu Val Val Gln Leu Gly Val Gln Arg Ala Leu 
            20                  25                  30          

Leu Val Ala Asp Pro Gly Val Val Gln Ala Gly Leu Leu Asp Arg Val 
        35                  40                  45              

Arg Glu Gly Leu Glu Gly Ser Ile Thr Val Ala Gly Ala Phe Thr Asp 
    50                  55                  60                  

Val Pro Pro Asp Ser Ser Val Ala Thr Val Glu Gln Gly Ala Ala Val 
65                  70                  75                  80  

Ala Arg Asp Ala Gly Ala Asp Val Leu Ile Ala Val Gly Gly Gly Ser 
                85                  90                  95      

Ala Ile Asp Thr Ala Lys Ala Met Arg Ile Leu Leu Thr Glu Gly Gly 
            100                 105                 110         

Thr Leu Tyr Asp Tyr Gln Gly Ala Asn Leu Leu Thr Arg Pro Leu Phe 
        115                 120                 125             

Pro Met Ile Ala Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Val Thr 
    130                 135                 140                 

Pro Val Ala Val Ile Arg Asp Glu Gln Ala Glu Gln Lys Leu Phe Phe 
145                 150                 155                 160 

Leu Ser Pro Tyr Leu Gly Pro Glu Leu Ala Ile Leu Asp Pro Glu Met 
                165                 170                 175     

Thr Arg Thr Leu Pro Pro Arg Leu Thr Ala Ala Thr Gly Met Asp Ala 
            180                 185                 190         

Leu Ser His Ala Ile Glu Thr Phe Val Gly Val Gly Ala Asn Pro Ile 
        195                 200                 205             

Thr Asp Ser Leu Ala Ile Gln Ala Ile Asp Met Ile Ser Asn Tyr Leu 
    210                 215                 220                 

Arg Ala Ala Thr His Asn Gly Glu Asp Met Glu Ala Arg Gly Asn Met 
225                 230                 235                 240 

Leu Ile Ala Ala Ala Ile Ala Gly Ile Ala Phe Ser Thr Thr Gly Ile 
                245                 250                 255     

Gly Val Asn Thr Gly Ile Ile His Ala Ala Ser His Thr Val Gly Ala 
            260                 265                 270         

Ala Tyr His Val His His Gly Thr Ala Asn Ser Ile Leu Leu Pro His 
        275                 280                 285             

Gly Met Arg Phe Asn Ala Pro Val Val Pro Asn Arg Met Val Arg Ile 
    290                 295                 300                 

Ala Arg Ala Met Gly Val Asn Ala Gly Gly Arg Ser Glu Glu Asp Val 
305                 310                 315                 320 

Ile Ala Asp Gly Ile Ala Ala Val Ala Lys Leu Ala Ala Asp Cys Gly 
                325                 330                 335     

Leu Pro Thr Arg Leu Arg Asp Val Gly Val Pro Glu Asp Ala Leu Pro 
            340                 345                 350         

Ala Leu Ala Glu Gly Thr Leu Met Asp Gly Ala Ile Met Ser Asn Pro 
        355                 360                 365             

Arg Pro Val Glu Tyr Glu Asp Ala Leu Ala Ile Leu Arg 
    370                 375                 380     

<210>   1214
<211>   332
<212>   PRT
<213>   Pelotomaculum thermopropionicum SI

<400>   1214
Phe Trp Thr Ser Gly Thr Ile Ile Thr Gly Arg Gly Ser Leu Lys Arg 
                5                   10                  15      

Ile Ala Asp Glu Ala Lys Gly Leu Gly Ala Thr Arg Val Leu Ile Val 
            20                  25                  30          

Thr Asp Pro Val Leu Leu Lys Thr Gly Leu Ile Glu Arg Val Lys Glu 
        35                  40                  45              

Ala Leu Ala Pro Ala Gly Leu Glu Thr Gly Ile Phe Ser Gly Val Glu 
    50                  55                  60                  

Pro Glu Pro Arg Leu Gln Ile Val Thr Glu Cys Leu Lys Ala Val Lys 
65                  70                  75                  80  

Glu Gly Gly Tyr Asp Leu Ile Val Ala Val Gly Gly Gly Ser Ser Met 
                85                  90                  95      

Asp Val Ser Lys Ala Ala Ser Val Leu Met Thr Asn Pro Gly Thr Ile 
            100                 105                 110         

Asn Asp Tyr Leu Gly Val Asn Leu Ile Pro Arg Pro Gly Ile Pro Val 
        115                 120                 125             

Ile Ala Val Pro Thr Thr Ala Gly Thr Gly Ser Glu Val Thr Pro Ile 
    130                 135                 140                 

Ala Ile Leu Ser Asp Val Glu Glu Gln Leu Lys Lys Gly Val Val Ser 
145                 150                 155                 160 

Pro Tyr Leu Leu Pro Arg Val Ala Ile Val Asp Pro Glu Leu Thr Val 
                165                 170                 175     

Thr Met Pro Pro Ala Ile Thr Ala Ala Thr Gly Met Asp Ala Leu Thr 
            180                 185                 190         

His Ala Val Glu Ser Tyr Ile Ser Val Asn Ala Thr Pro Ile Thr Asp 
        195                 200                 205             

Ile Leu Ala Leu Glu Ala Ile Arg Leu Ile Ala Leu Asn Leu Arg Thr 
    210                 215                 220                 

Ala Val Ala Asn Gly Gln Asp Ile Glu Ala Arg Ser Asn Met Ser Met 
225                 230                 235                 240 

Ala Ser Leu Leu Ala Gly Ile Ala Phe Ala Asn Ala Gly Val Gly Ala 
                245                 250                 255     

Val His Ala Leu Ala Tyr Pro Leu Gly Ala Gln Phe His Val Pro His 
            260                 265                 270         

Gly Val Ala Asn Ala Val Leu Leu Pro Tyr Val Met Glu Ser Asn Leu 
        275                 280                 285             

Leu Gly Ala Leu Pro Arg Phe Lys Thr Met Ala Leu Ala Met Gly Glu 
    290                 295                 300                 

Lys Val Glu Asp Leu Ser Asp Arg Leu Ala Ala Asp Lys Phe Asn Glu 
305                 310                 315                 320 

Ala Ile Lys Leu Leu Ala Ala Asp Ile Arg Ile Pro 
                325                 330         

<210>   1215
<211>   444
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1208

<400>   1215
Met Gly Arg Thr Arg Ser Thr Asn Thr Arg Ser Ser Ser Thr Tyr Thr 
                5                   10                  15      

Arg Arg Ser Cys Thr Ser Ser Lys Thr Ala Ile Gly Ile Pro Leu Cys 
            20                  25                  30          

Cys Pro Thr Gly Pro Asp Ala Ile Asp Phe Cys Glu Val Val Arg Arg 
        35                  40                  45              

Met Pro Tyr Ile Arg Ser Gly Phe Gln Phe Met Ala Arg Thr Thr Ile 
    50                  55                  60                  

Thr Asn Gly Val Gly Ser Arg Val Phe Leu Pro Glu Thr Val Arg Gly 
65                  70                  75                  80  

Leu Gly Gly Lys Arg Ala Phe Val Val Thr Asp Pro Gly Ile Val Arg 
                85                  90                  95      

Ala Gly Leu Leu Asp Lys Ile Leu Glu Leu Phe Asp Leu Val Pro Thr 
            100                 105                 110         

Pro Val Thr Ile Ala Gly Val Phe Asp Arg Val Glu Gln Asp Ala Lys 
        115                 120                 125             

Ala His Ile Ile Asn Glu Ala Ala Arg Ala Tyr Arg Glu Cys Ala Ala 
    130                 135                 140                 

Asp Ser Leu Ile Ala Leu Gly Gly Gly Ser Val Leu Asp Thr Val Lys 
145                 150                 155                 160 

Gly Ile Lys Trp Met Val Ser Arg Gly Leu Thr Asp Ile Arg Pro Ala 
                165                 170                 175     

Leu Ile Gly Asn Val Leu Glu Met Trp Pro Glu Ala Gln Pro Ile Phe 
            180                 185                 190         

Ile Pro His Val Ala Leu Pro Thr Thr Ala Gly Thr Gly Ala Glu Ala 
        195                 200                 205             

Ser Pro Ile Ala Val Val Phe His Asp Asp Leu Gly Val Lys Val Asn 
    210                 215                 220                 

Leu Ile Asn Pro Phe Ile Asn Ala Asp Ile Ala Ile Leu Asp Pro Glu 
225                 230                 235                 240 

Leu Thr Val Gly Leu Pro Pro Ser Ile Thr Ala Phe Thr Gly Phe Asp 
                245                 250                 255     

Ala Leu Thr His Ala Ile Glu Gly Phe Phe Ser Pro Gln Ala Asn Pro 
            260                 265                 270         

Phe Thr Asp Ala Tyr Ala Ile Gln Ser Ala Arg Met Ile Phe Glu Asn 
        275                 280                 285             

Leu Pro Lys Ala Val Ala Asn Gly Gln Asp Leu Thr Ala Arg Ala Asn 
    290                 295                 300                 

Met Leu Met Ala Ser Thr Met Ala Ile Ile Ser Phe Ser Leu Ala Leu 
305                 310                 315                 320 

Asn Ala Ile Pro Val His Asn Met Ala His Ala Phe Gly Ala Lys Phe 
                325                 330                 335     

Gly Ile Pro His Gly Leu Ala Asn Ala Val Leu Leu Pro Asn Val Met 
            340                 345                 350         

Ala Ala Met Pro Ala Phe Tyr Arg Ala Arg Ile Arg Glu Phe Met Ala 
        355                 360                 365             

Ala Ile Gly Leu Glu Ala Pro Ser Asp Pro Asp Ala Ala Leu Glu Ser 
    370                 375                 380                 

Phe Ile Gln Arg Ile Arg Asp Leu Arg Gln Gln Val Gly Leu Pro Ala 
385                 390                 395                 400 

Thr Phe Ala Asp Tyr Gln Leu Asp Lys Arg Gln Leu Gly Lys Met Val 
                405                 410                 415     

Asp Leu Val His Ala Asp Pro Ser Gly Val Val Tyr Arg Leu Pro Asp 
            420                 425                 430         

Ala Ile Ile Gln Arg Val Thr Arg Glu Val Ala Ser 
        435                 440                 

<210>   1216
<211>   444
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1208

<400>   1216
Met Gly Arg Thr Arg Ser Thr Asn Thr Arg Ser Ser Ser Thr Tyr Thr 
                5                   10                  15      

Arg Arg Ser Cys Thr Ser Ser Lys Thr Ala Ile Gly Ile Pro Leu Cys 
            20                  25                  30          

Cys Pro Thr Gly Pro Asp Ala Ile Asp Phe Cys Glu Val Val Arg Arg 
        35                  40                  45              

Met Pro Tyr Ile Arg Ser Gly Phe Gln Phe Met Ala Arg Thr Thr Ile 
    50                  55                  60                  

Thr Asn Gly Val Gly Ser Arg Val Phe Leu Pro Glu Thr Val Arg Gly 
65                  70                  75                  80  

Leu Gly Gly Lys Arg Ala Phe Val Val Thr Asp Pro Gly Ile Val Arg 
                85                  90                  95      

Ala Gly Leu Leu Asp Lys Ile Leu Glu Leu Phe Asp Leu Val Pro Thr 
            100                 105                 110         

Pro Val Thr Ile Ala Gly Val Phe Asp Arg Val Glu Gln Asp Ala Lys 
        115                 120                 125             

Ala His Ile Ile Asn Glu Ala Ala Arg Ala Tyr Arg Glu Cys Ala Ala 
    130                 135                 140                 

Asp Ser Leu Ile Ala Leu Gly Gly Gly Ser Val Leu Asp Thr Val Lys 
145                 150                 155                 160 

Gly Ile Lys Trp Met Val Ser Arg Gly Leu Thr Asp Ile Arg Pro Ala 
                165                 170                 175     

Leu Ile Gly Asn Val Leu Glu Met Trp Pro Glu Ala Gln Pro Ile Phe 
            180                 185                 190         

Ile Pro His Val Ala Leu Pro Thr Thr Ala Gly Thr Gly Ala Glu Ala 
        195                 200                 205             

Ser Pro Ile Ala Val Val Phe His Asp Asp Leu Gly Val Lys Val Asn 
    210                 215                 220                 

Leu Ile Asn Pro Phe Ile Asn Ala Asp Ile Ala Ile Leu Asp Pro Glu 
225                 230                 235                 240 

Leu Thr Val Gly Leu Pro Pro Ser Ile Thr Ala Phe Thr Gly Phe Asp 
                245                 250                 255     

Ala Leu Thr His Ala Ile Glu Gly Phe Phe Ser Pro Gln Ala Asn Pro 
            260                 265                 270         

Phe Thr Asp Ala Tyr Ala Ile Gln Ser Ala Arg Met Ile Phe Glu Asn 
        275                 280                 285             

Leu Pro Lys Ala Ile Ala Asn Gly Gln Asp Leu Thr Ala Arg Ala Asn 
    290                 295                 300                 

Met Leu Met Ala Ser Thr Met Ala Ile Ile Ser Phe Ser Leu Ala Leu 
305                 310                 315                 320 

Asn Ala Ile Pro Val His Asn Met Ala His Ala Phe Gly Ala Lys Phe 
                325                 330                 335     

Gly Ile Pro His Gly Leu Ala Asn Ala Val Leu Leu Pro Asn Val Met 
            340                 345                 350         

Ala Ala Met Pro Ala Phe Tyr Arg Ala Arg Ile Arg Glu Phe Met Ala 
        355                 360                 365             

Ala Ile Gly Leu Asp Ala Pro Ser Asp Pro Asp Ala Ala Leu Glu Ser 
    370                 375                 380                 

Phe Ile Gln Arg Ile Arg Asp Leu Arg Gln Gln Val Gly Leu Pro Ala 
385                 390                 395                 400 

Thr Phe Ala Asp Tyr Gln Leu Asp Lys Arg Gln Leu Gly Lys Met Val 
                405                 410                 415     

Asp Leu Val His Ala Asp Pro Ser Gly Val Val Tyr Arg Leu Pro Asp 
            420                 425                 430         

Ala Ile Ile Gln Arg Val Thr Arg Glu Val Ala Ser 
        435                 440                 

<210>   1217
<211>   444
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1208

<400>   1217
Met Gly Arg Thr Arg Ser Thr Asn Thr Arg Ser Ser Ser Thr Tyr Thr 
                5                   10                  15      

Arg Arg Ser Cys Thr Ser Ser Lys Thr Ala Ile Gly Ile Pro Leu Cys 
            20                  25                  30          

Cys Pro Thr Gly Pro Asp Ala Ile Asp Phe Cys Glu Val Val Arg Arg 
        35                  40                  45              

Met Pro Tyr Ile Arg Ser Gly Phe Gln Phe Met Ala Arg Thr Thr Ile 
    50                  55                  60                  

Thr Asn Gly Val Gly Ser Arg Val Phe Leu Pro Glu Thr Val Arg Gly 
65                  70                  75                  80  

Leu Gly Gly Lys Arg Ala Phe Val Val Thr Asp Pro Gly Ile Val Arg 
                85                  90                  95      

Ala Gly Leu Leu Asp Lys Ile Leu Glu Leu Phe Asp Leu Val Pro Thr 
            100                 105                 110         

Pro Val Thr Ile Ala Gly Val Phe Asp Arg Val Glu Gln Asp Ala Lys 
        115                 120                 125             

Ala His Ile Ile Asn Glu Ala Ala Arg Ala Tyr Arg Glu Cys Ala Ala 
    130                 135                 140                 

Asp Ser Leu Ile Ala Leu Gly Gly Gly Ser Val Leu Asp Thr Val Lys 
145                 150                 155                 160 

Gly Ile Lys Trp Met Val Ser Arg Gly Leu Thr Asp Ile Arg Pro Ala 
                165                 170                 175     

Leu Ile Gly Asn Val Leu Glu Met Trp Pro Glu Ala Gln Pro Ile Phe 
            180                 185                 190         

Ile Pro His Val Ala Leu Pro Thr Thr Ala Gly Thr Gly Ala Glu Ala 
        195                 200                 205             

Ser Pro Ile Ala Val Val Phe His Asp Asp Leu Gly Val Lys Val Asn 
    210                 215                 220                 

Leu Ile Asn Pro Phe Ile Asn Ala Asp Ile Ala Ile Leu Asp Pro Glu 
225                 230                 235                 240 

Leu Thr Val Gly Leu Pro Pro Ser Ile Thr Ala Phe Thr Gly Phe Asp 
                245                 250                 255     

Ala Leu Thr His Ala Ile Glu Gly Phe Phe Ser Pro Gln Ala Asn Pro 
            260                 265                 270         

Phe Thr Asp Ala Tyr Ala Ile Gln Ser Ala Arg Met Ile Phe Glu Gln 
        275                 280                 285             

Leu Pro Lys Ala Val Ala Asn Gly Gln Asp Leu Thr Ala Arg Ala Asn 
    290                 295                 300                 

Met Leu Met Ala Ser Thr Met Ala Ile Ile Ser Phe Ser Leu Ala Leu 
305                 310                 315                 320 

Asn Ala Ile Pro Val His Asn Met Ala His Ala Phe Gly Ala Lys Phe 
                325                 330                 335     

Gly Ile Pro His Gly Leu Ala Asn Ala Val Leu Leu Pro Asn Val Met 
            340                 345                 350         

Ala Ala Met Pro Ala Phe Tyr Arg Ala Arg Ile Arg Glu Phe Met Ala 
        355                 360                 365             

Ala Ile Gly Leu Asp Ala Pro Ser Asp Pro Asp Ala Ala Leu Glu Ser 
    370                 375                 380                 

Phe Ile Gln Arg Ile Arg Asp Leu Arg Gln Gln Val Gly Leu Pro Ala 
385                 390                 395                 400 

Thr Phe Ala Asp Tyr Gln Leu Asp Lys Arg Gln Leu Gly Lys Met Val 
                405                 410                 415     

Asp Leu Val His Ala Asp Pro Ser Gly Val Val Tyr Arg Leu Pro Asp 
            420                 425                 430         

Ala Ile Ile Gln Arg Val Thr Arg Glu Val Ala Ser 
        435                 440                 

<210>   1218
<211>   444
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1208

<400>   1218
Met Gly Arg Thr Arg Ser Thr Asn Thr Arg Ser Ser Ser Thr Tyr Thr 
                5                   10                  15      

Arg Arg Ser Cys Thr Ser Ser Lys Thr Ala Ile Gly Ile Pro Leu Cys 
            20                  25                  30          

Cys Pro Thr Gly Pro Asp Ala Ile Asp Phe Cys Glu Val Val Arg Arg 
        35                  40                  45              

Met Pro Tyr Ile Arg Ser Gly Phe Gln Phe Met Ala Arg Thr Thr Ile 
    50                  55                  60                  

Thr Asn Gly Val Gly Ser Arg Val Phe Leu Pro Glu Thr Val Arg Gly 
65                  70                  75                  80  

Leu Gly Gly Lys Arg Ala Phe Val Val Thr Asp Pro Gly Ile Val Arg 
                85                  90                  95      

Ala Gly Leu Leu Asp Lys Ile Leu Glu Leu Phe Asp Leu Val Pro Thr 
            100                 105                 110         

Pro Val Thr Ile Ala Gly Val Phe Asp Arg Val Glu Gln Asp Ala Lys 
        115                 120                 125             

Ala His Ile Ile Asn Glu Ala Ala Arg Ala Tyr Arg Glu Cys Ala Ala 
    130                 135                 140                 

Asp Ser Leu Ile Ala Leu Gly Gly Gly Ser Val Leu Asp Thr Val Lys 
145                 150                 155                 160 

Gly Ile Lys Trp Met Val Ser Arg Gly Leu Thr Asp Ile Arg Pro Ala 
                165                 170                 175     

Leu Ile Gly Asn Val Leu Glu Met Trp Pro Glu Ala Gln Pro Ile Phe 
            180                 185                 190         

Ile Pro His Val Ala Leu Pro Thr Thr Ala Gly Thr Gly Ala Glu Ala 
        195                 200                 205             

Ser Pro Ile Ala Val Val Phe His Asp Asp Leu Gly Val Lys Val Asn 
    210                 215                 220                 

Leu Ile Asn Pro Phe Ile Asn Ala Asp Ile Ala Ile Leu Asp Pro Glu 
225                 230                 235                 240 

Leu Thr Val Gly Leu Pro Pro Ser Ile Thr Ala Phe Thr Gly Phe Asp 
                245                 250                 255     

Ala Leu Thr His Ala Ile Glu Gly Phe Phe Ser Pro Gln Ala Asn Pro 
            260                 265                 270         

Phe Thr Asp Ala Tyr Ala Ile Gln Ser Ala Arg Met Ile Phe Glu Asn 
        275                 280                 285             

Leu Pro Lys Ala Val Ala Asn Gly Gln Asp Leu Thr Ala Arg Ala Asn 
    290                 295                 300                 

Met Leu Met Ala Ser Thr Met Ala Ile Ile Ser Phe Ser Ile Ala Leu 
305                 310                 315                 320 

Asn Ala Ile Pro Val His Asn Met Ala His Ala Phe Gly Ala Lys Phe 
                325                 330                 335     

Gly Ile Pro His Gly Leu Ala Asn Ala Val Leu Leu Pro Asn Val Met 
            340                 345                 350         

Ala Ala Met Pro Ala Phe Tyr Arg Ala Arg Ile Arg Glu Phe Met Ala 
        355                 360                 365             

Ala Ile Gly Leu Asp Ala Pro Ser Asp Pro Asp Ala Ala Leu Glu Ser 
    370                 375                 380                 

Phe Ile Gln Arg Ile Arg Asp Leu Arg Gln Gln Val Gly Leu Pro Ala 
385                 390                 395                 400 

Thr Phe Ala Asp Tyr Gln Leu Asp Lys Arg Gln Leu Gly Lys Met Val 
                405                 410                 415     

Asp Leu Val His Ala Asp Pro Ser Gly Val Val Tyr Arg Leu Pro Asp 
            420                 425                 430         

Ala Ile Ile Gln Arg Val Thr Arg Glu Val Ala Ser 
        435                 440                 

<210>   1219
<211>   444
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1208

<400>   1219
Met Gly Arg Thr Arg Ser Thr Asn Thr Arg Ser Ser Ser Thr Tyr Thr 
                5                   10                  15      

Arg Arg Ser Cys Thr Ser Ser Lys Thr Ala Ile Gly Ile Pro Leu Cys 
            20                  25                  30          

Cys Pro Thr Gly Pro Asp Ala Ile Asp Phe Cys Glu Val Val Arg Arg 
        35                  40                  45              

Met Pro Tyr Ile Arg Ser Gly Phe Gln Phe Met Ala Arg Thr Thr Ile 
    50                  55                  60                  

Thr Asn Gly Val Gly Ser Arg Val Phe Leu Pro Glu Thr Val Arg Gly 
65                  70                  75                  80  

Leu Gly Gly Lys Arg Ala Phe Val Val Thr Asp Pro Gly Ile Val Arg 
                85                  90                  95      

Ala Gly Leu Leu Asp Lys Ile Leu Glu Leu Phe Asp Leu Val Pro Thr 
            100                 105                 110         

Pro Val Thr Ile Ala Gly Val Phe Asp Arg Val Glu Gln Asp Ala Lys 
        115                 120                 125             

Ala His Ile Ile Asn Glu Ala Ala Arg Ala Tyr Arg Glu Cys Ala Ala 
    130                 135                 140                 

Asp Ser Leu Ile Ala Leu Gly Gly Gly Ser Val Leu Asp Thr Val Lys 
145                 150                 155                 160 

Gly Ile Arg Trp Met Val Ser Arg Gly Leu Thr Asp Ile Arg Pro Ala 
                165                 170                 175     

Leu Ile Gly Asn Val Leu Glu Met Trp Pro Glu Ala Gln Pro Ile Phe 
            180                 185                 190         

Ile Pro His Val Ala Leu Pro Thr Thr Ala Gly Thr Gly Ala Glu Ala 
        195                 200                 205             

Ser Pro Ile Ala Val Val Phe His Asp Asp Leu Gly Val Lys Val Asn 
    210                 215                 220                 

Leu Ile Asn Pro Phe Ile Asn Ala Asp Ile Ala Ile Leu Asp Pro Glu 
225                 230                 235                 240 

Leu Thr Val Gly Leu Pro Pro Ser Ile Thr Ala Phe Thr Gly Phe Asp 
                245                 250                 255     

Ala Leu Thr His Ala Ile Glu Gly Phe Phe Ser Pro Gln Ala Asn Pro 
            260                 265                 270         

Phe Thr Asp Ala Tyr Ala Ile Gln Ser Ala Arg Met Ile Phe Glu Asn 
        275                 280                 285             

Leu Pro Lys Ala Val Ala Asn Gly Gln Asp Leu Thr Ala Arg Ala Asn 
    290                 295                 300                 

Met Leu Met Ala Ser Thr Met Ala Ile Ile Ser Phe Ser Leu Ala Leu 
305                 310                 315                 320 

Asn Ala Ile Pro Val His Asn Met Ala His Ala Phe Gly Ala Lys Phe 
                325                 330                 335     

Gly Ile Pro His Gly Leu Ala Asn Ala Val Leu Leu Pro Asn Val Met 
            340                 345                 350         

Ala Ala Met Pro Ala Phe Tyr Arg Ala Arg Ile Arg Glu Phe Met Ala 
        355                 360                 365             

Ala Ile Gly Leu Asp Ala Pro Ser Asp Pro Asp Ala Ala Leu Glu Ser 
    370                 375                 380                 

Phe Ile Gln Arg Ile Arg Asp Leu Arg Gln Gln Val Gly Leu Pro Ala 
385                 390                 395                 400 

Thr Phe Ala Asp Tyr Gln Leu Asp Lys Arg Gln Leu Gly Lys Met Val 
                405                 410                 415     

Asp Leu Val His Ala Asp Pro Ser Gly Val Val Tyr Arg Leu Pro Asp 
            420                 425                 430         

Ala Ile Ile Gln Arg Val Thr Arg Glu Val Ala Ser 
        435                 440                 

<210>   1220
<211>   1335
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1209

<400>   1220
ttgggccgta cgcgctcgac gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc       60

acgagctcga aaaccgccat tggtattcca ttgtgttgcc cgacagggcc tgacgcgatc      120

gacttctgcg aggtggtgag gcgcatgccg tacattcgat ctggctttca attcatggcg      180

cgaacgacca tcacaaacgg cgtcggatcg cgcgtgtttt tgccggagac cgtgcgcggg      240

ctcggcggca agcgggcttt tgtggtgacg gacccgggca ttgtccgcgc cggcctcttg      300

gacaagatcc tggagttgtt cgatctcgtg ccgacgcccg tgaccattgc gggcgtgttc      360

gatcgcgtcg agcaggacgc gaaggcacac atcatcaacg aagccgcgcg tgcctaccgc      420

gagtgcgccg cggatagtct catcgccctc ggcggaggca gcgtgctcga cacggtcaag      480

gggatcaagt ggatggtgag ccgtggcctc accgacatcc gcccggcgct catcggcaac      540

gtgctcgaga tgtggcccga ggcgcagccc atcttcattc cgcacgtggc gctgcccacc      600

accgccggaa ccggggcgga ggcctcgccc atcgcggtgg tcttccacga cgatctcggc      660

gtcaaggtga acctcatcaa cccgttcatc aacgccgaca tcgccattct cgatccggaa      720

ctcaccgtcg gcttgccgcc cagcatcacc gccttcaccg gcttcgacgc gctgacgcac      780

gccatcgagg gcttcttctc gccgcaggcc aacccgttca ccgacgcgta cgccatccaa      840

tccgcgcgca tgatcttcga aaacctgccg aaggccgtgg ccaacgggca ggacctgacc      900

gcccgcgcca acatgctgat ggcgagcacg atggccatca tcagcttcag cctggcctta      960

aacgcgattc ccgtccacaa catggcgcac gcgttcggcg cgaagttcgg cattccgcac     1020

ggactcgcga acgcggtgct cctgccgaac gtgatggccg cgatgcccgc gttctatcgc     1080

gcgcgcatcc gcgagttcat ggcggccatc ggcttggaag cgccgtccga tcccgatgcg     1140

gcgctcgaat cgttcattca acgcattcgc gatcttcgtc aacaggtcgg cctgcctgcg     1200

acgttcgccg actaccagct cgacaagcgg cagctcggca agatggtgga tctggtgcac     1260

gccgatccgt ccggcgtcgt ctatcgcctg ccggatgcca tcatccagcg cgtcacgcgc     1320

gaggtggcga gctaa                                                      1335


<210>   1221
<211>   1335
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1209

<400>   1221
ttgggccgta cgcgctcgac gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc       60

acgagctcga aaaccgccat tggtattcca ttgtgttgcc cgacagggcc tgacgcgatc      120

gacttctgcg aggtggtgag gcgcatgccg tacattcgat ctggctttca attcatggcg      180

cgaacgacca tcacaaacgg cgtcggatcg cgcgtgtttt tgccggagac cgtgcgcggg      240

ctcggcggca agcgggcttt tgtggtgacg gacccgggca ttgtccgcgc cggcctcttg      300

gacaagatcc tggagttgtt cgatctcgtg ccgacgcccg tgaccattgc gggcgtgttc      360

gatcgcgtcg agcaggacgc gaaggcacac atcatcaacg aagccgcgcg tgcctaccgc      420

gagtgcgccg cggatagtct catcgccctc ggcggaggca gcgtgctcga cacggtcaag      480

gggatcaagt ggatggtgag ccgtggcctc accgacatcc gcccggcgct catcggcaac      540

gtgctcgaga tgtggcccga ggcgcagccc atcttcattc cgcacgtggc gctgcccacc      600

accgccggaa ccggggcgga ggcctcgccc atcgcggtgg tcttccacga cgatctcggc      660

gtcaaggtga acctcatcaa cccgttcatc aacgccgaca tcgccattct cgatccggaa      720

ctcaccgtcg gcttgccgcc cagcatcacc gccttcaccg gcttcgacgc gctgacgcac      780

gccatcgagg gcttcttctc gccgcaggcc aacccgttca ccgacgcgta cgccatccaa      840

tccgcgcgca tgatcttcga aaacctgccg aaggccattg ccaacgggca ggacctgacc      900

gcccgcgcca acatgctgat ggcgagcacg atggccatca tcagcttcag cctggcctta      960

aacgcgattc ccgtccacaa catggcgcac gcgttcggcg cgaagttcgg cattccgcac     1020

ggactcgcga acgcggtgct cctgccgaac gtgatggccg cgatgcccgc gttctatcgc     1080

gcgcgcatcc gcgagttcat ggcggccatc ggcttggacg cgccgtccga tcccgatgcg     1140

gcgctcgaat cgttcattca acgcattcgc gatcttcgtc aacaggtcgg cctgcctgcg     1200

acgttcgccg actaccagct cgacaagcgg cagctcggca agatggtgga tctggtgcac     1260

gccgatccgt ccggcgtcgt ctatcgcctg ccggatgcca tcatccagcg cgtcacgcgc     1320

gaggtggcga gctaa                                                      1335


<210>   1222
<211>   1335
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1209

<400>   1222
ttgggccgta cgcgctcgac gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc       60

acgagctcga aaaccgccat tggtattcca ttgtgttgcc cgacagggcc tgacgcgatc      120

gacttctgcg aggtggtgag gcgcatgccg tacattcgat ctggctttca attcatggcg      180

cgaacgacca tcacaaacgg cgtcggatcg cgcgtgtttt tgccggagac cgtgcgcggg      240

ctcggcggca agcgggcttt tgtggtgacg gacccgggca ttgtccgcgc cggcctcttg      300

gacaagatcc tggagttgtt cgatctcgtg ccgacgcccg tgaccattgc gggcgtgttc      360

gatcgcgtcg agcaggacgc gaaggcacac atcatcaacg aagccgcgcg tgcctaccgc      420

gagtgcgccg cggatagtct catcgccctc ggcggaggca gcgtgctcga cacggtcaag      480

gggatcaagt ggatggtgag ccgtggcctc accgacatcc gcccggcgct catcggcaac      540

gtgctcgaga tgtggcccga ggcgcagccc atcttcattc cgcacgtggc gctgcccacc      600

accgccggaa ccggggcgga ggcctcgccc atcgcggtgg tcttccacga cgatctcggc      660

gtcaaggtga acctcatcaa cccgttcatc aacgccgaca tcgccattct cgatccggaa      720

ctcaccgtcg gcttgccgcc cagcatcacc gccttcaccg gcttcgacgc gctgacgcac      780

gccatcgagg gcttcttctc gccgcaggcc aacccgttca ccgacgcgta cgccatccaa      840

tccgcgcgca tgatcttcga acaactgccg aaggccgtgg ccaacgggca ggacctgacc      900

gcccgcgcca acatgctgat ggcgagcacg atggccatca tcagcttcag cctggcctta      960

aacgcgattc ccgtccacaa catggcgcac gcgttcggcg cgaagttcgg cattccgcac     1020

ggactcgcga acgcggtgct cctgccgaac gtgatggccg cgatgcccgc gttctatcgc     1080

gcgcgcatcc gcgagttcat ggcggccatc ggcttggacg cgccgtccga tcccgatgcg     1140

gcgctcgaat cgttcattca acgcattcgc gatcttcgtc aacaggtcgg cctgcctgcg     1200

acgttcgccg actaccagct cgacaagcgg cagctcggca agatggtgga tctggtgcac     1260

gccgatccgt ccggcgtcgt ctatcgcctg ccggatgcca tcatccagcg cgtcacgcgc     1320

gaggtggcga gctaa                                                      1335


<210>   1223
<211>   1335
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1209

<400>   1223
ttgggccgta cgcgctcgac gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc       60

acgagctcga aaaccgccat tggtattcca ttgtgttgcc cgacagggcc tgacgcgatc      120

gacttctgcg aggtggtgag gcgcatgccg tacattcgat ctggctttca attcatggcg      180

cgaacgacca tcacaaacgg cgtcggatcg cgcgtgtttt tgccggagac cgtgcgcggg      240

ctcggcggca agcgggcttt tgtggtgacg gacccgggca ttgtccgcgc cggcctcttg      300

gacaagatcc tggagttgtt cgatctcgtg ccgacgcccg tgaccattgc gggcgtgttc      360

gatcgcgtcg agcaggacgc gaaggcacac atcatcaacg aagccgcgcg tgcctaccgc      420

gagtgcgccg cggatagtct catcgccctc ggcggaggca gcgtgctcga cacggtcaag      480

gggatcaagt ggatggtgag ccgtggcctc accgacatcc gcccggcgct catcggcaac      540

gtgctcgaga tgtggcccga ggcgcagccc atcttcattc cgcacgtggc gctgcccacc      600

accgccggaa ccggggcgga ggcctcgccc atcgcggtgg tcttccacga cgatctcggc      660

gtcaaggtga acctcatcaa cccgttcatc aacgccgaca tcgccattct cgatccggaa      720

ctcaccgtcg gcttgccgcc cagcatcacc gccttcaccg gcttcgacgc gctgacgcac      780

gccatcgagg gcttcttctc gccgcaggcc aacccgttca ccgacgcgta cgccatccaa      840

tccgcgcgca tgatcttcga aaacctgccg aaggccgtgg ccaacgggca ggacctgacc      900

gcccgcgcca acatgctgat ggcgagcacg atggccatca tcagcttcag cattgcctta      960

aacgcgattc ccgtccacaa catggcgcac gcgttcggcg cgaagttcgg cattccgcac     1020

ggactcgcga acgcggtgct cctgccgaac gtgatggccg cgatgcccgc gttctatcgc     1080

gcgcgcatcc gcgagttcat ggcggccatc ggcttggacg cgccgtccga tcccgatgcg     1140

gcgctcgaat cgttcattca acgcattcgc gatcttcgtc aacaggtcgg cctgcctgcg     1200

acgttcgccg actaccagct cgacaagcgg cagctcggca agatggtgga tctggtgcac     1260

gccgatccgt ccggcgtcgt ctatcgcctg ccggatgcca tcatccagcg cgtcacgcgc     1320

gaggtggcga gctaa                                                      1335


<210>   1224
<211>   1335
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1209

<400>   1224
ttgggccgta cgcgctcgac gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc       60

acgagctcga aaaccgccat tggtattcca ttgtgttgcc cgacagggcc tgacgcgatc      120

gacttctgcg aggtggtgag gcgcatgccg tacattcgat ctggctttca attcatggcg      180

cgaacgacca tcacaaacgg cgtcggatcg cgcgtgtttt tgccggagac cgtgcgcggg      240

ctcggcggca agcgggcttt tgtggtgacg gacccgggca ttgtccgcgc cggcctcttg      300

gacaagatcc tggagttgtt cgatctcgtg ccgacgcccg tgaccattgc gggcgtgttc      360

gatcgcgtcg agcaggacgc gaaggcacac atcatcaacg aagccgcgcg tgcctaccgc      420

gagtgcgccg cggatagtct catcgccctc ggcggaggca gcgtgctcga cacggtcaag      480

gggatccgtt ggatggtgag ccgtggcctc accgacatcc gcccggcgct catcggcaac      540

gtgctcgaga tgtggcccga ggcgcagccc atcttcattc cgcacgtggc gctgcccacc      600

accgccggaa ccggggcgga ggcctcgccc atcgcggtgg tcttccacga cgatctcggc      660

gtcaaggtga acctcatcaa cccgttcatc aacgccgaca tcgccattct cgatccggaa      720

ctcaccgtcg gcttgccgcc cagcatcacc gccttcaccg gcttcgacgc gctgacgcac      780

gccatcgagg gcttcttctc gccgcaggcc aacccgttca ccgacgcgta cgccatccaa      840

tccgcgcgca tgatcttcga aaacctgccg aaggccgtgg ccaacgggca ggacctgacc      900

gcccgcgcca acatgctgat ggcgagcacg atggccatca tcagcttcag cctggcctta      960

aacgcgattc ccgtccacaa catggcgcac gcgttcggcg cgaagttcgg cattccgcac     1020

ggactcgcga acgcggtgct cctgccgaac gtgatggccg cgatgcccgc gttctatcgc     1080

gcgcgcatcc gcgagttcat ggcggccatc ggcttggacg cgccgtccga tcccgatgcg     1140

gcgctcgaat cgttcattca acgcattcgc gatcttcgtc aacaggtcgg cctgcctgcg     1200

acgttcgccg actaccagct cgacaagcgg cagctcggca agatggtgga tctggtgcac     1260

gccgatccgt ccggcgtcgt ctatcgcctg ccggatgcca tcatccagcg cgtcacgcgc     1320

gaggtggcga gctaa                                                      1335


<210>   1225
<211>   510
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1225
Met Val Met Thr Ser Val Arg Leu Pro Glu Tyr Gly Met Phe Ile Asp 
                5                   10                  15      

Gly Glu Tyr Thr Pro Ala Glu Ser Gly Glu Met Phe Glu Val Val Asn 
            20                  25                  30          

Pro Ala Thr Gly Gln Pro Cys Ala Arg Val Ala Lys Ser Asp Ala Arg 
        35                  40                  45              

Asp Val Asp Arg Ala Val Arg Ser Ala Arg Arg Ala Phe Glu Ser Gly 
    50                  55                  60                  

Glu Trp Ser Arg Ala Lys Pro His Glu Arg Ala Gln Val Leu Leu Arg 
65                  70                  75                  80  

Phe Ala Asp Glu Ile Val Ala His Ala Gln Glu Ile Ala Phe Leu Glu 
                85                  90                  95      

Ile Leu Thr Ser Gly Ala Thr Val Arg Arg Val Ser Asn Ala Asp Leu 
            100                 105                 110         

Leu Leu Ile Val Asp Leu Leu Gln Gln Thr Ala Arg Phe Ala Gln Ala 
        115                 120                 125             

Tyr Glu Tyr Ala Lys Thr Leu Pro Leu Arg Pro Phe Pro Gln Pro Ser 
    130                 135                 140                 

His Asn Gln Val Trp Arg Glu Pro Val Gly Val Cys Ala Gly Ile Thr 
145                 150                 155                 160 

Ala Trp Asn Tyr Pro Leu Ile Leu Ala Met Trp Lys Leu Ala Pro Ala 
                165                 170                 175     

Leu Ala Met Gly Asn Ser Ile Val Leu Lys Pro Ala Ser Asn Thr Pro 
            180                 185                 190         

Leu Ser Thr Leu Lys Leu Ala Glu Leu Ala Ala Lys Ala Gly Leu Pro 
        195                 200                 205             

Lys Gly Val Phe Asn Val Val Thr Gly Pro Gly Ser Ser Val Gly Glu 
    210                 215                 220                 

Ala Leu Val Thr His Pro Glu Val Asp Lys Ile Ala Phe Thr Gly Ser 
225                 230                 235                 240 

Thr Glu Val Gly Lys Arg Ile Met Gln Leu Ala Ala Gln Gly Val Lys 
                245                 250                 255     

Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Ala Ile Val Leu Pro 
            260                 265                 270         

Asp Ala Asp Leu Asp Leu Ala Ile Pro Gly Ile Leu Phe Gly Val Phe 
        275                 280                 285             

Leu His Ala Gly Gln Val Cys Glu Cys Gly Thr Arg Val Ile Val His 
    290                 295                 300                 

Glu Asp Ile Tyr Glu Glu Val Val Asn Arg Leu Ala Glu Met Ala Ser 
305                 310                 315                 320 

Gln Ile Lys Leu Gly Asn Pro Leu Asp Asp Lys Val Gly Met Gly Pro 
                325                 330                 335     

Ile Ile Ser Glu Ser Gln Met Asn Thr Ile Leu Ser Tyr Ile Glu Ser 
            340                 345                 350         

Gly Lys Ala Glu Gly Ala Arg Leu Val Cys Gly Gly Gln Arg Ala Thr 
        355                 360                 365             

Gly Gly Gly Leu Asp Ala Gly Tyr Phe Val Gln Pro Thr Ile Phe Ala 
    370                 375                 380                 

Asp Val Asp Asn Arg Met Lys Ile Ala Gln Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 

Val Leu Ala Val Met Lys Ala Arg Asp Val Asp Glu Ala Val Arg Leu 
                405                 410                 415     

Ala Asn Asp Thr Val Tyr Gly Leu Ala Gly Gly Val Trp Thr Arg Asp 
            420                 425                 430         

Leu Asn Gln Ala Tyr Arg Ile Ala Arg Glu Ile Arg Ala Gly Thr Ile 
        435                 440                 445             

Trp Val Asn Asp Trp His Met Phe Arg Ser Asp Ala Pro Phe Gly Gly 
    450                 455                 460                 

Tyr Lys Met Ser Gly Phe Gly Arg Glu Ile Gly Pro Tyr Ala Leu Asp 
465                 470                 475                 480 

Glu Tyr Thr Gln Leu Lys His Val His Ala Ser Phe Val His Glu Leu 
                485                 490                 495     

Glu Asn Arg His Trp Tyr Ser Ile Val Leu Pro Asp Arg Ala 
            500                 505                 510 

<210>   1226
<211>   1533
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1226
atggtcatga cgagtgtgag actccccgag tacggcatgt tcatcgacgg cgagtacacg       60

cctgcggaaa gcggggagat gttcgaggtg gtgaatcccg ccacggggca gccctgcgcg      120

cgcgtggcga agtcggacgc gcgagacgtg gatcgcgccg tgcgaagcgc tcgccgcgcg      180

ttcgagtcgg gcgagtggtc ccgcgccaag ccccacgagc gggcccaggt gttgcttcgg      240

tttgcggacg agatcgtcgc gcacgcgcag gagattgcgt ttctggagat cttgacctcc      300

ggcgcgacgg tgcggcgcgt gtcgaacgcc gacttgcttc tcattgtcga tttgctccag      360

cagaccgcgc ggttcgcgca ggcgtacgaa tacgcgaaga cgcttccgct ccggccgttt      420

ccgcagccga gccacaacca ggtatggagg gagcccgtgg gcgtgtgcgc cgggatcacg      480

gcgtggaact atccactcat cctcgcgatg tggaagctcg cgcccgcgct cgccatgggg      540

aactccatcg tgttgaaacc ggcgtccaac acgccgcttt ccacgctcaa gcttgccgag      600

ctcgcggcga aggccgggct gccgaagggc gtgttcaacg tcgtcacggg gccaggatcg      660

tcggtgggcg aggcgctcgt cacgcacccg gaggtcgaca aaatcgcctt caccggatcc      720

accgaggtgg gcaagcggat catgcagctc gcggcgcagg gcgtcaagcg cgtgaccctg      780

gagttgggcg gcaagtcgcc ggccatcgtg ctgccggacg cggacctgga tctggcgata      840

cccggcatcc tgtttggcgt cttcctgcac gccgggcagg tgtgcgagtg cgggacgcgc      900

gtgattgtcc acgaggacat ctacgaggaa gtcgtgaatc gcctggccga gatggcctcg      960

cagatcaagc tcggcaatcc gctcgatgac aaggtgggca tggggcccat catctccgag     1020

tcgcagatga acaccattct gagctacatc gagtcgggca aggcggaagg cgcgcgcctc     1080

gtgtgcggcg gccagcgcgc cacgggaggc ggcctggacg caggttactt tgtgcagccg     1140

accatcttcg ccgacgtcga caaccgcatg aaaattgcgc aggaggagat cttcggcccc     1200

gtgctcgcgg tcatgaaggc gcgggacgtg gacgaggcgg ttcggctggc caacgatacc     1260

gtctatgggc tggcgggcgg cgtctggacg cgcgatctca accaggccta tcgcatcgcg     1320

cgcgagatcc gggcggggac catctgggtg aacgactggc acatgttccg cagcgacgcg     1380

ccgttcggcg gctacaagat gagcgggttc ggccgcgaga ttgggccgta cgcgctcgac     1440

gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc acgagctcga aaaccgccat     1500

tggtattcca ttgtgttgcc cgacagggcc tga                                  1533


<210>   1227
<211>   501
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1227
Thr His Val Gln Val His His Phe Pro Leu Phe Ile Asp Gly Gln Trp 
                5                   10                  15      

Gln Pro Ala Thr Ser Gly Glu Thr Phe His Val Tyr Asn Pro Ala Thr 
            20                  25                  30          

Gly Glu Val Val Ala Thr Val Ala Lys Ala Thr Ala Asp Asp Val Asp 
        35                  40                  45              

Arg Ala Val Lys Ala Ala Arg Lys Ala Phe Asp Glu Thr Asp Trp Lys 
    50                  55                  60                  

Ala Met Lys Pro Lys Glu Arg Ala Arg Val Leu Asn Ala Ile Ala Gln 
65                  70                  75                  80  

Ala Ile Ala Ala Asn Ala Gln Glu Leu Ala Tyr Leu Glu Ala Ile Ser 
                85                  90                  95      

Ser Gly Gly Thr Ile Arg Arg Ile Ser Ser Ile Asp Ile Leu Gln Thr 
            100                 105                 110         

Val Asp Leu Phe Gln Thr Met Ala Asn Ile Val Gln Glu Tyr Pro Phe 
        115                 120                 125             

Ser Glu Thr Leu Pro Ile Pro Pro Phe Pro Gly Pro Ala His Asn Phe 
    130                 135                 140                 

Val Trp Arg Glu Pro Ile Gly Val Cys Ala Ala Ile Thr Pro Trp Asn 
145                 150                 155                 160 

Leu Pro Leu Met Ile Ala Ser Trp Lys Ile Ala Pro Ala Leu Ala Ala 
                165                 170                 175     

Gly Asn Thr Ile Val Val Lys Pro Ala Ser Tyr Thr Pro Leu Ser Thr 
            180                 185                 190         

Leu Lys Leu Ala Glu Ile Ile Ser Ser Phe Val Pro Pro Gly Val Ile 
        195                 200                 205             

Asn Val Val Ala Gly Pro Gly Ala Asp Val Gly Glu Ala Leu Val Arg 
    210                 215                 220                 

His Pro Gln Val Asp Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly 
225                 230                 235                 240 

Arg Arg Ile Met Ala Leu Ala Ala Glu Thr Val Lys Asn Val Thr Leu 
                245                 250                 255     

Glu Leu Gly Gly Lys Ser Pro Asn Ile Leu Leu Glu Asp Ala Asp Leu 
            260                 265                 270         

Asp Leu Ala Val Pro Gly Ser Leu Phe Gly Val Phe Leu His Ser Gly 
        275                 280                 285             

Gln Leu Cys Glu Ser Gly Thr Arg Leu Phe Val Pro Asp Arg Leu His 
    290                 295                 300                 

Asp Glu Val Val Glu Arg Leu Val Ala Leu Thr Lys Thr Leu Gln Ile 
305                 310                 315                 320 

Gly His Pro Leu Asp Pro Ala Thr Asp Val Gly Pro Val Ile Ser Lys 
                325                 330                 335     

Arg Gln Lys Glu Thr Val Leu Ser Tyr Ile Glu Ala Gly Lys Gln Glu 
            340                 345                 350         

Gly Ala Thr Ile Val Cys Gly Gly His Glu Val Glu Val Pro Gly Cys 
        355                 360                 365             

Glu Gly Gly His Phe Val Ala Pro Thr Ile Phe Ser Asn Val Thr Asn 
    370                 375                 380                 

Asp Met Lys Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Ser Ile 
385                 390                 395                 400 

Ile Arg Tyr His Asp Val Glu Glu Ala Val Thr Met Ala Asn Asp Thr 
                405                 410                 415     

Ile Tyr Gly Leu Ala Ala Gly Val Trp Thr Arg Asp Val Asn Lys Ala 
            420                 425                 430         

Tyr Ala Ile Ala Gly Arg Leu Gln Ala Gly Val Val Trp Ile Asn Asp 
        435                 440                 445             

Trp His Met Leu Arg Asn Asp Ala Pro Phe Gly Gly Tyr Lys Gln Ser 
    450                 455                 460                 

Gly Ile Gly Arg Glu Met Gly Lys Tyr Ser Leu Asp Ala Tyr Thr Gln 
465                 470                 475                 480 

Leu Lys His Val His Thr Ser Met Val Pro Glu Leu Gly Lys Arg Lys 
                485                 490                 495     

Trp Tyr Gln Val Leu 
            500     

<210>   1228
<211>   500
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   1228
Leu Arg Ser Phe Gly Leu Tyr Ile Asp Gly Ala Trp Val Ala Ala Ser 
                5                   10                  15      

Asp Ala Ala Ser Glu Thr Leu Tyr Asn Pro Ala Thr Gly Glu Pro Val 
            20                  25                  30          

Ala Gln Val Ala Arg Ala Thr Ile His Asp Ile Asp Arg Ala Val Gly 
        35                  40                  45              

Ala Ala Arg Lys Ser Phe Asp Ile Gly Ser Trp Ala Gln Met Arg Pro 
    50                  55                  60                  

Val Asp Arg Ala Lys Thr Ile Glu Ala Ile Ala Asp Leu Leu Glu Glu 
65                  70                  75                  80  

Asn Thr Asp Glu Leu Ala Glu Leu Glu Thr Leu Asn Gly Gly Ala Thr 
                85                  90                  95      

Leu Arg Lys Ser Ser Trp Leu Asp Ile Pro Val Gly Ile Glu His Leu 
            100                 105                 110         

Arg Tyr Phe Ala Asp Leu Ala Arg Gln His Pro Met Gln Thr Leu Pro 
        115                 120                 125             

Tyr Ile Asp Phe Pro Ser Pro Ser Ala Asn Ala Val Trp Arg Glu Pro 
    130                 135                 140                 

Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Tyr Pro Phe Leu Met 
145                 150                 155                 160 

Ala Ile Trp Lys Ile Gly Pro Ala Leu Ala Ala Gly Asn Ser Leu Val 
                165                 170                 175     

Leu Lys Pro Ala Ser Leu Thr Pro Val Thr Ala Leu Arg Met Ala Glu 
            180                 185                 190         

Leu Ile His Glu Ala Asp Leu Leu Pro His Gly Val Phe Asn Val Val 
        195                 200                 205             

Thr Gly Pro Gly Gly Leu Val Gly Glu Arg Leu Thr Ser His Pro Ala 
    210                 215                 220                 

Val Asp Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Arg Arg Ile 
225                 230                 235                 240 

Ala Glu Val Ala Gly Arg Asn Leu Lys Arg Val Thr Leu Glu Leu Gly 
                245                 250                 255     

Gly Lys Ser Pro Val Val Val Leu Pro Asn Ala Asp Leu Asp Leu Ala 
            260                 265                 270         

Val Asp Gly Ala Ile Trp Ala Ala Phe Met His Ser Gly Gln Ser Cys 
        275                 280                 285             

Glu Ala Gly Thr Arg Leu Leu Leu Pro Asp Ser Leu His Asp Gln Phe 
    290                 295                 300                 

Val Glu Arg Met Val Ala Arg Val Glu Gln Leu Val Leu Gly Asp Pro 
305                 310                 315                 320 

Leu Asp Leu Thr Thr Asp Leu Gly Pro Leu Val Ser Ala Ala Gln Lys 
                325                 330                 335     

Arg Ala Val Glu Ala Tyr Ile Glu Leu Gly Ile Gln Glu Gly Ala Thr 
            340                 345                 350         

Leu Arg Cys Gly Gly Val Gly Ile Asp Asp Pro Asn Leu Ala Asn Gly 
        355                 360                 365             

His Phe Val Arg Pro Thr Ile Phe Thr Asn Val His Asn Gln Met Arg 
    370                 375                 380                 

Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Ser Val Ile Arg Tyr 
385                 390                 395                 400 

His Thr Val Gly Glu Ala Ile Thr Leu Ala Asn Asp Thr Asn Tyr Gly 
                405                 410                 415     

Leu Ala Ala Ser Val Trp Ser Arg Asp Leu Gln Asp Ala Gln Glu Val 
            420                 425                 430         

Ala Arg Ala Ile Arg Ala Gly Thr Val Trp Ile Asn Asp His His Leu 
        435                 440                 445             

Ile Asn Ala Lys Ala Pro Phe Gly Gly Tyr Lys Asp Ser Gly Ile Gly 
    450                 455                 460                 

Arg Glu Leu Gly Pro Asn Ala Leu Asp Ala Tyr Ser Glu Ile Lys His 
465                 470                 475                 480 

Ile His Thr Asp Leu Thr Gln Glu Arg Thr Arg Arg Ile Trp Val Asp 
                485                 490                 495     

Ile Val Thr Pro 
            500 

<210>   1229
<211>   501
<212>   PRT
<213>   Chloroflexus aurantiacus J-10-fl

<400>   1229
Leu Pro His Tyr Asp Leu Tyr Ile Asp Gly Ala Trp Gln Pro Ala Glu 
                5                   10                  15      

Asn Gly Gln Thr Phe Thr Val Tyr Asp Pro Ala Thr Ser Gln Pro Ile 
            20                  25                  30          

Ala Thr Cys Ala Ser Ala Thr His Ser Asp Val Asp Arg Ala Val Arg 
        35                  40                  45              

Ala Ala Arg Ala Ala Phe Asp His Gly Pro Trp Pro His Thr Ser Pro 
    50                  55                  60                  

Ala Gln Arg Ala Glu Ile Leu His Ala Ile Ala Asp Ala Leu Glu Ala 
65                  70                  75                  80  

Arg Asn Phe Glu Leu Ala Glu Ile Glu Ser Arg Asp Ala Gly Val Pro 
                85                  90                  95      

Ile Arg Lys Thr Thr Tyr Asn Asp Ile Thr Leu Gly Leu Glu Ile Leu 
            100                 105                 110         

Arg Gly Cys Ala Glu Met Ala Arg Lys His Pro Tyr Glu Pro Leu Pro 
        115                 120                 125             

Trp Asn Asp Leu Pro Ser Val Ser Trp Asn Phe Val Trp Arg Glu Pro 
    130                 135                 140                 

Ile Gly Val Cys Ala Gln Ile Ile Pro Trp Asn Tyr Ala Phe Cys Met 
145                 150                 155                 160 

Ala Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Thr Val Val 
                165                 170                 175     

Phe Lys Pro Ser Ser Leu Ala Pro Leu Ser Thr Leu Ala Ile Phe Gln 
            180                 185                 190         

Thr Ile His Asp Leu Asn Leu Leu Pro Lys Gly Val Ile Asn Leu Val 
        195                 200                 205             

Leu Gly Pro Gly Gly Asp Val Gly Glu Tyr Leu Val Thr His Pro Ala 
    210                 215                 220                 

Val Asp Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Arg Lys Ile 
225                 230                 235                 240 

Met Ala Leu Ala Ala Pro His Ile Lys Arg Val Thr Leu Glu Leu Gly 
                245                 250                 255     

Gly Lys Asn Ala Met Leu Ile Leu Pro Asp Ala Asp Leu Asp Leu Val 
            260                 265                 270         

Val Asp Gly Val Leu Trp Gly Ala Phe Tyr His Ser Gly Gln Leu Cys 
        275                 280                 285             

Glu Ala Gly Ser Arg Leu Leu Val Pro His Ala Leu His Asp Thr Leu 
    290                 295                 300                 

Val Glu Arg Leu Val Glu Arg Val Arg Gly Met Arg Ile Gly Asp Pro 
305                 310                 315                 320 

Met Asp Leu Glu Thr Asp Ile Gly Pro Leu Ile Ser Glu Arg Gln Arg 
                325                 330                 335     

Glu Lys Val Glu Tyr Tyr Ile Ala Val Gly Arg Glu Glu Gly Ala Thr 
            340                 345                 350         

Val Val Ile Gly Gly Gly Arg Pro Ile Gly Glu Ala Phe Ala Asn Gly 
        355                 360                 365             

His Tyr Val Glu Pro Thr Ile Phe Thr Gly Val Arg Pro Glu Met Arg 
    370                 375                 380                 

Ile Ala Arg Glu Glu Ile Phe Gly Pro Val Leu Ser Val Ile Ala Tyr 
385                 390                 395                 400 

Asp Glu Ile Gly Glu Ala Ile Arg Ile Ala Asn Asp Ser Ile Tyr Gly 
                405                 410                 415     

Leu Ala Ala Ser Val Trp Ser Arg Asp Leu Gln His Ala Leu Ser Val 
            420                 425                 430         

Val Arg Arg Ile Arg Ala Gly Thr Val Trp Ile Asn Glu His His Val 
        435                 440                 445             

Leu Asn Pro Arg Ala Pro Phe Gly Gly Tyr Arg Gln Ser Gly Phe Gly 
    450                 455                 460                 

Arg Glu Met Gly Arg Tyr Gly Leu Asp Glu Tyr Thr Glu Val Lys His 
465                 470                 475                 480 

Ile His Val Asp Leu Met Gln Arg Arg Gln Gly Arg Leu Trp Trp Asp 
                485                 490                 495     

Thr Leu Leu Pro Glu 
            500     

<210>   1230
<211>   501
<212>   PRT
<213>   Chloroflexus aggregans DSM 9485

<400>   1230
Leu Pro His Tyr Asp Leu Tyr Ile Asn Gly Ala Trp Gln Pro Ala Ser 
                5                   10                  15      

Ser Lys Gln Thr Phe Thr Val Phe Asp Pro Ala Asn Gly Gln Pro Leu 
            20                  25                  30          

Ala Thr Cys Ala Ser Ala Ser Pro Thr Asp Val Asp Arg Ala Ile Ala 
        35                  40                  45              

Ala Ala Arg Ser Ala Phe Asp His Gly Pro Trp Pro His Thr Ser Pro 
    50                  55                  60                  

Ala Arg Arg Ala Glu Ile Leu His Ala Leu Ala Asp Ala Leu Glu Ala 
65                  70                  75                  80  

Arg Asn Phe Glu Leu Ala Glu Ile Glu Ser Arg Asn Ala Gly Val Pro 
                85                  90                  95      

Leu Arg Lys Thr Thr Tyr Asn Asp Ile Thr Leu Gly Ile Glu Ile Leu 
            100                 105                 110         

Arg Gly Cys Ala Glu Met Ala Arg Lys His Pro Tyr Glu Pro Leu Pro 
        115                 120                 125             

Trp Asn Asp Leu Pro Ser Val Ser Trp Asn Phe Val Trp Arg Glu Pro 
    130                 135                 140                 

Ile Gly Val Cys Ala Gln Ile Ile Pro Trp Asn Tyr Ala Phe Cys Met 
145                 150                 155                 160 

Ala Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Thr Val Val 
                165                 170                 175     

Phe Lys Pro Ser Ser Leu Ala Pro Leu Ser Thr Leu Ala Ile Ile Gln 
            180                 185                 190         

Ala Ile His Glu Leu Asn Leu Leu Pro Lys Gly Val Val Asn Leu Val 
        195                 200                 205             

Leu Gly Pro Gly Gly Glu Val Gly Glu Tyr Leu Val Ala His Pro Asp 
    210                 215                 220                 

Val Asp Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Arg Lys Ile 
225                 230                 235                 240 

Met Ala Leu Ala Ala Pro His Ile Lys Arg Val Thr Leu Glu Leu Gly 
                245                 250                 255     

Gly Lys Asn Ala Met Ile Ile Leu Pro Asp Ala Asp Leu Asp Leu Val 
            260                 265                 270         

Val Asp Gly Val Leu Trp Gly Ala Phe Tyr His Ser Gly Gln Leu Cys 
        275                 280                 285             

Glu Ala Gly Ser Arg Leu Leu Val Pro His Ala Leu His Asp Thr Leu 
    290                 295                 300                 

Val Ser Arg Leu Val Glu Arg Val Arg Thr Met Arg Ile Gly Asp Pro 
305                 310                 315                 320 

Met Asp Leu Glu Thr Asp Ile Gly Pro Leu Ile Ser Glu Gln Gln Arg 
                325                 330                 335     

Ala Lys Val Glu Arg Tyr Ile Ala Ile Gly Arg Glu Glu Gly Ala Thr 
            340                 345                 350         

Val Val Ile Gly Gly Arg Arg Pro Pro Asp Glu Ala Arg Ala Lys Gly 
        355                 360                 365             

Tyr Tyr Val Glu Pro Thr Ile Phe Thr Gly Val Arg Pro Glu Met Arg 
    370                 375                 380                 

Ile Ala Arg Glu Glu Ile Phe Gly Pro Val Leu Ala Val Ile Ala Tyr 
385                 390                 395                 400 

Glu Glu Val Ser Glu Ala Ile Lys Ile Ala Asn Asp Ser Ile Tyr Gly 
                405                 410                 415     

Leu Ala Ala Ser Val Trp Ser Arg Asp Leu Gln Gln Ala Leu Ala Val 
            420                 425                 430         

Ala Lys Arg Ile Arg Ala Gly Thr Val Trp Ile Asn Glu His His Val 
        435                 440                 445             

Leu Asn Pro Gln Ala Pro Phe Gly Gly Tyr Arg Gln Ser Gly Phe Gly 
    450                 455                 460                 

Arg Glu Met Gly Arg Tyr Gly Leu Asp Glu Tyr Thr Glu Val Lys His 
465                 470                 475                 480 

Ile His Val Asp Leu Met Gln Arg Arg Gln Gly Arg Leu Trp Trp Asp 
                485                 490                 495     

Thr Leu Leu Pro Glu 
            500     

<210>   1231
<211>   499
<212>   PRT
<213>   Roseiflexus sp. RS-1

<400>   1231
Leu Pro Cys Tyr Gly Leu Tyr Ile Asp Gly Ser Trp Val Asp Ala Glu 
                5                   10                  15      

Gly Gly Thr Met Pro Val Asn Glu Pro Ala Leu Gly Arg Pro Met Ala 
            20                  25                  30          

Arg Val Ala Arg Gly Ser Ala Ala Asp Val Asp Arg Ala Val Ala Ala 
        35                  40                  45              

Ala Arg Glu Ala Phe Asp Arg Gly Pro Trp Pro His Thr Pro Gly His 
    50                  55                  60                  

Glu Arg Ala Arg Val Leu Asn Ala Ile Ala Asp Leu Ile Glu Glu His 
65                  70                  75                  80  

Thr Ala Glu Phe Ala Glu Leu Glu Thr Arg Asn Leu Gly Ala Pro Leu 
                85                  90                  95      

Arg Lys Thr Thr Phe Val Asp Ile Pro Trp Ser Val Glu His Leu Arg 
            100                 105                 110         

Val Phe Ala Glu Leu Ala Thr Ile His Pro Tyr Glu Pro Leu Pro Trp 
        115                 120                 125             

Thr Asp Val Pro Ser Val Ser Trp Asn Phe Val Trp Arg Glu Pro Ile 
    130                 135                 140                 

Gly Val Cys Gly Gln Ile Val Pro Trp Asn Tyr Pro Leu Leu Met Thr 
145                 150                 155                 160 

Ile Trp Lys Ile Ala Pro Ala Leu Ala Ala Gly Asn Thr Ile Val Leu 
                165                 170                 175     

Lys Pro Ala Ser Tyr Thr Pro Leu Thr Ala Leu Arg Leu Thr Gln Leu 
            180                 185                 190         

Ile His Glu Ala Gly Leu Leu Pro Arg Gly Val Leu Asn Val Val Thr 
        195                 200                 205             

Gly Pro Gly Ala Glu Val Gly Asp Ala Leu Ala Arg His Pro Gly Val 
    210                 215                 220                 

Asp Lys Val Ser Phe Thr Gly Ser Thr Glu Thr Gly Arg His Ile Met 
225                 230                 235                 240 

Arg Leu Ala Ser Asp Thr Ile Lys Arg Leu Thr Leu Glu Leu Gly Gly 
                245                 250                 255     

Lys Ser Pro Ser Leu Val Met Pro Asp Ala Asp Leu Glu Leu Ala Thr 
            260                 265                 270         

Asp Gly Val Leu Phe Gly Val Phe Phe Asn Gly Gly Gln Ser Cys Glu 
        275                 280                 285             

Ala Gly Thr Arg Cys Leu Val Pro Glu Ser Leu His Asp Glu Phe Leu 
    290                 295                 300                 

Glu Arg Leu Val Thr Arg Ala Arg Ser Leu Arg Ile Gly Asp Pro Leu 
305                 310                 315                 320 

Asp Leu Glu Thr Asp Leu Gly Pro Leu Val Ser Glu Ala Gln Cys Arg 
                325                 330                 335     

Ile Val Glu Glu Tyr Ile Glu Val Gly Lys Asn Glu Gly Ala Arg Leu 
            340                 345                 350         

Val Thr Gly Gly Arg Arg Val Arg Val Pro Gly Phe Glu Arg Gly Pro 
        355                 360                 365             

Phe Val Glu Pro Thr Ile Phe Thr Asn Val Leu Asn Gly Thr Arg Leu 
    370                 375                 380                 

Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Ser Val Ile Pro Tyr Arg 
385                 390                 395                 400 

Thr Val Thr Glu Ala Ile Glu Leu Ala Asn Ala Ser Arg Tyr Gly Leu 
                405                 410                 415     

Gly Ala Ala Val Trp Ser Arg Asp Leu Gln Gly Ala Ile Glu Val Ala 
            420                 425                 430         

Lys Arg Ile Arg Thr Gly Thr Val Trp Ile Asn Asp His His Ile Ile 
        435                 440                 445             

Leu Pro Arg Ala Pro Phe Gly Gly Tyr Lys Gln Ser Gly Ile Gly Arg 
    450                 455                 460                 

Glu His Gly Ile Tyr Gly Leu Met Ala Tyr Thr Glu Leu Lys His Ile 
465                 470                 475                 480 

His Val Asp Leu Met Gln Lys Arg Thr Gly Arg Val Trp Trp Asp Val 
                485                 490                 495     

Leu Ile Pro 
            

<210>   1232
<211>   510
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1225

<400>   1232
Met Val Met Thr Ser Val Arg Leu Pro Glu Tyr Gly Met Phe Ile Asp 
                5                   10                  15      

Gly Glu Tyr Thr Pro Ala Glu Ser Gly Glu Met Phe Glu Val Val Asn 
            20                  25                  30          

Pro Ala Thr Gly Gln Pro Cys Ala Arg Val Ala Lys Ser Asp Ala Arg 
        35                  40                  45              

Asp Val Asp Arg Ala Val Arg Ser Ala Arg Lys Ala Phe Glu Ser Gly 
    50                  55                  60                  

Glu Trp Ser Arg Ala Lys Pro His Glu Arg Ala Gln Val Leu Leu Arg 
65                  70                  75                  80  

Phe Ala Asp Glu Ile Val Ala His Ala Gln Glu Ile Ala Phe Leu Glu 
                85                  90                  95      

Ile Leu Thr Ser Gly Ala Thr Val Arg Arg Val Ser Asn Ala Asp Leu 
            100                 105                 110         

Leu Leu Ile Val Asp Leu Leu Gln Gln Thr Ala Arg Phe Ala Gln Ala 
        115                 120                 125             

Tyr Glu Tyr Ala Lys Thr Leu Pro Leu Arg Pro Phe Pro Gln Pro Ser 
    130                 135                 140                 

His Asn Gln Val Trp Arg Glu Pro Val Gly Val Cys Ala Gly Ile Thr 
145                 150                 155                 160 

Ala Trp Asn Tyr Pro Leu Ile Leu Ala Met Trp Lys Leu Ala Pro Ala 
                165                 170                 175     

Leu Ala Met Gly Asn Ser Ile Val Leu Lys Pro Ala Ser Asn Thr Pro 
            180                 185                 190         

Leu Ser Thr Leu Lys Leu Ala Glu Leu Ala Ala Lys Ala Gly Leu Pro 
        195                 200                 205             

Lys Gly Val Phe Asn Val Val Thr Gly Pro Gly Ser Ser Val Gly Glu 
    210                 215                 220                 

Ala Leu Val Thr His Pro Glu Val Asp Lys Ile Ala Phe Thr Gly Ser 
225                 230                 235                 240 

Thr Glu Val Gly Lys Arg Ile Met Gln Leu Ala Ala Gln Gly Val Lys 
                245                 250                 255     

Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Ala Ile Val Leu Pro 
            260                 265                 270         

Asp Ala Asp Leu Asp Leu Ala Ile Pro Gly Ile Leu Phe Gly Val Phe 
        275                 280                 285             

Leu His Ala Gly Gln Val Cys Glu Cys Gly Thr Arg Val Ile Val His 
    290                 295                 300                 

Glu Asp Ile Tyr Glu Glu Val Val Asn Arg Leu Ala Glu Met Ala Ser 
305                 310                 315                 320 

Gln Ile Lys Leu Gly Asn Pro Leu Asp Asp Lys Val Gly Met Gly Pro 
                325                 330                 335     

Ile Ile Ser Glu Ser Gln Met Asn Thr Ile Leu Ser Tyr Ile Glu Ser 
            340                 345                 350         

Gly Lys Ala Glu Gly Ala Arg Leu Val Cys Gly Gly Gln Arg Ala Thr 
        355                 360                 365             

Gly Gly Gly Leu Asp Ala Gly Tyr Phe Val Gln Pro Thr Ile Phe Ala 
    370                 375                 380                 

Asp Val Asp Asn Arg Met Lys Ile Ala Gln Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 

Val Leu Ala Val Met Lys Ala Arg Asp Val Asp Glu Ala Val Arg Leu 
                405                 410                 415     

Ala Asn Asp Thr Val Tyr Gly Leu Ala Gly Gly Val Trp Thr Arg Asp 
            420                 425                 430         

Leu Asn Gln Ala Tyr Arg Ile Ala Arg Glu Ile Arg Ala Gly Thr Ile 
        435                 440                 445             

Trp Val Asn Asp Trp His Met Phe Arg Ser Asp Ala Pro Phe Gly Gly 
    450                 455                 460                 

Tyr Lys Met Ser Gly Phe Gly Arg Glu Ile Gly Pro Tyr Ala Leu Asp 
465                 470                 475                 480 

Glu Tyr Thr Gln Leu Lys His Val His Ala Ser Phe Val His Glu Leu 
                485                 490                 495     

Glu Asn Arg His Trp Tyr Ser Ile Val Leu Pro Asp Arg Ala 
            500                 505                 510 

<210>   1233
<211>   510
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1225

<400>   1233
Met Val Met Thr Ser Val Arg Leu Pro Glu Tyr Gly Met Phe Ile Asp 
                5                   10                  15      

Gly Glu Tyr Thr Pro Ala Glu Ser Gly Glu Met Phe Glu Val Val Asn 
            20                  25                  30          

Pro Ala Thr Gly Gln Pro Cys Ala Arg Val Ala Lys Ser Asp Ala Arg 
        35                  40                  45              

Asp Val Asp Arg Ala Val Arg Ser Ala Arg Arg Ala Phe Glu Ser Gly 
    50                  55                  60                  

Glu Trp Ser Arg Ala Lys Pro His Glu Arg Ala Gln Val Leu Leu Arg 
65                  70                  75                  80  

Phe Ala Asp Glu Ile Val Ala His Ala Gln Glu Ile Ala Phe Leu Glu 
                85                  90                  95      

Ile Leu Thr Ser Gly Ala Thr Val Arg Arg Val Ser Asn Ala Asp Leu 
            100                 105                 110         

Leu Leu Ile Val Asp Leu Leu Gln Gln Thr Ala Arg Phe Ala Gln Ala 
        115                 120                 125             

Tyr Glu Tyr Ala Lys Thr Leu Pro Leu Lys Pro Phe Pro Gln Pro Ser 
    130                 135                 140                 

His Asn Gln Val Trp Arg Glu Pro Val Gly Val Cys Ala Gly Ile Thr 
145                 150                 155                 160 

Ala Trp Asn Tyr Pro Leu Ile Leu Ala Met Trp Lys Leu Ala Pro Ala 
                165                 170                 175     

Leu Ala Met Gly Asn Ser Ile Val Leu Lys Pro Ala Ser Asn Thr Pro 
            180                 185                 190         

Leu Ser Thr Leu Lys Leu Ala Glu Leu Ala Ala Lys Ala Gly Leu Pro 
        195                 200                 205             

Lys Gly Val Phe Asn Val Val Thr Gly Pro Gly Ser Ser Val Gly Glu 
    210                 215                 220                 

Ala Leu Val Thr His Pro Glu Val Asp Lys Ile Ala Phe Thr Gly Ser 
225                 230                 235                 240 

Thr Glu Val Gly Lys Arg Ile Met Gln Leu Ala Ala Gln Gly Val Lys 
                245                 250                 255     

Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Ala Ile Val Leu Pro 
            260                 265                 270         

Asp Ala Asp Leu Asp Leu Ala Ile Pro Gly Ile Leu Phe Gly Val Phe 
        275                 280                 285             

Leu His Ala Gly Gln Val Cys Glu Cys Gly Thr Arg Val Ile Val His 
    290                 295                 300                 

Glu Asp Ile Tyr Glu Glu Val Val Asn Arg Leu Ala Glu Met Ala Ser 
305                 310                 315                 320 

Gln Ile Lys Leu Gly Asn Pro Leu Asp Asp Lys Val Gly Met Gly Pro 
                325                 330                 335     

Ile Ile Ser Glu Ser Gln Met Asn Thr Ile Leu Ser Tyr Ile Glu Ser 
            340                 345                 350         

Gly Lys Ala Glu Gly Ala Arg Leu Val Cys Gly Gly Gln Arg Ala Thr 
        355                 360                 365             

Gly Gly Gly Leu Asp Ala Gly Tyr Phe Val Gln Pro Thr Ile Phe Ala 
    370                 375                 380                 

Asp Val Asp Asn Arg Met Lys Ile Ala Gln Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 

Val Leu Ala Val Met Lys Ala Arg Asp Val Asp Glu Ala Val Arg Leu 
                405                 410                 415     

Ala Asn Asp Thr Val Tyr Gly Leu Ala Gly Gly Val Trp Thr Arg Asp 
            420                 425                 430         

Leu Asn Gln Ala Tyr Arg Ile Ala Arg Glu Ile Arg Ala Gly Thr Ile 
        435                 440                 445             

Trp Val Asn Asp Trp His Met Phe Arg Ser Asp Ala Pro Phe Gly Gly 
    450                 455                 460                 

Tyr Lys Met Ser Gly Phe Gly Arg Glu Ile Gly Pro Tyr Ala Leu Asp 
465                 470                 475                 480 

Glu Tyr Thr Gln Leu Lys His Val His Ala Ser Phe Val His Glu Leu 
                485                 490                 495     

Glu Asn Arg His Trp Tyr Ser Ile Val Leu Pro Asp Arg Ala 
            500                 505                 510 

<210>   1234
<211>   510
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1225

<400>   1234
Met Val Met Thr Ser Val Arg Leu Pro Glu Tyr Gly Met Phe Ile Asp 
                5                   10                  15      

Gly Glu Tyr Thr Pro Ala Glu Ser Gly Glu Met Phe Glu Val Val Asn 
            20                  25                  30          

Pro Ala Thr Gly Gln Pro Cys Ala Arg Val Ala Lys Ser Asp Ala Arg 
        35                  40                  45              

Asp Val Asp Arg Ala Val Arg Ser Ala Arg Arg Ala Phe Glu Ser Gly 
    50                  55                  60                  

Glu Trp Ser Arg Ala Lys Pro His Glu Arg Ala Gln Ile Leu Leu Arg 
65                  70                  75                  80  

Phe Ala Asp Glu Ile Val Ala His Ala Gln Glu Ile Ala Phe Leu Glu 
                85                  90                  95      

Ile Leu Thr Ser Gly Ala Thr Val Arg Arg Val Ser Asn Ala Asp Leu 
            100                 105                 110         

Leu Leu Ile Val Asp Leu Leu Gln Gln Thr Ala Arg Phe Ala Gln Ala 
        115                 120                 125             

Tyr Glu Tyr Ala Lys Thr Leu Pro Leu Arg Pro Phe Pro Gln Pro Ser 
    130                 135                 140                 

His Asn Gln Val Trp Arg Glu Pro Val Gly Val Cys Ala Gly Ile Thr 
145                 150                 155                 160 

Ala Trp Asn Tyr Pro Leu Ile Leu Ala Met Trp Lys Leu Ala Pro Ala 
                165                 170                 175     

Leu Ala Met Gly Asn Ser Ile Val Leu Lys Pro Ala Ser Asn Thr Pro 
            180                 185                 190         

Leu Ser Thr Leu Lys Leu Ala Glu Leu Ala Ala Lys Ala Gly Leu Pro 
        195                 200                 205             

Lys Gly Val Phe Asn Val Val Thr Gly Pro Gly Ser Ser Val Gly Glu 
    210                 215                 220                 

Ala Leu Val Thr His Pro Glu Val Asp Lys Ile Ala Phe Thr Gly Ser 
225                 230                 235                 240 

Thr Glu Val Gly Lys Arg Ile Met Gln Leu Ala Ala Gln Gly Val Lys 
                245                 250                 255     

Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Ala Ile Val Leu Pro 
            260                 265                 270         

Asp Ala Asp Leu Asp Leu Ala Ile Pro Gly Ile Leu Phe Gly Val Phe 
        275                 280                 285             

Leu His Ala Gly Gln Val Cys Glu Cys Gly Thr Arg Val Ile Val His 
    290                 295                 300                 

Glu Asp Ile Tyr Glu Glu Val Val Asn Arg Leu Ala Glu Met Ala Ser 
305                 310                 315                 320 

Gln Ile Lys Leu Gly Asn Pro Leu Asp Asp Lys Val Gly Met Gly Pro 
                325                 330                 335     

Ile Ile Ser Glu Ser Gln Met Asn Thr Ile Leu Ser Tyr Ile Glu Ser 
            340                 345                 350         

Gly Lys Ala Glu Gly Ala Arg Leu Val Cys Gly Gly Gln Arg Ala Thr 
        355                 360                 365             

Gly Gly Gly Leu Asp Ala Gly Tyr Phe Val Gln Pro Thr Ile Phe Ala 
    370                 375                 380                 

Asp Val Asp Asn Arg Met Lys Ile Ala Gln Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 

Val Leu Ala Val Met Lys Ala Arg Asp Val Asp Glu Ala Val Arg Leu 
                405                 410                 415     

Ala Asn Asp Thr Val Tyr Gly Leu Ala Gly Gly Val Trp Thr Arg Asp 
            420                 425                 430         

Leu Asn Gln Ala Tyr Arg Ile Ala Arg Glu Ile Arg Ala Gly Thr Ile 
        435                 440                 445             

Trp Val Asn Asp Trp His Met Phe Arg Ser Asp Ala Pro Phe Gly Gly 
    450                 455                 460                 

Tyr Lys Met Ser Gly Phe Gly Arg Glu Ile Gly Pro Tyr Ala Leu Asp 
465                 470                 475                 480 

Glu Tyr Thr Gln Leu Lys His Val His Ala Ser Phe Val His Glu Leu 
                485                 490                 495     

Glu Asn Arg His Trp Tyr Ser Ile Val Leu Pro Asp Arg Ala 
            500                 505                 510 

<210>   1235
<211>   510
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1225

<400>   1235
Met Val Met Thr Ser Val Arg Leu Pro Glu Tyr Gly Met Phe Ile Asp 
                5                   10                  15      

Gly Glu Tyr Thr Pro Ala Glu Ser Gly Glu Met Phe Glu Val Val Asn 
            20                  25                  30          

Pro Ala Thr Gly Gln Pro Cys Ala Arg Val Ala Lys Ser Asp Ala Arg 
        35                  40                  45              

Asp Val Asp Arg Ala Val Arg Ser Ala Arg Arg Ala Phe Glu Ser Gly 
    50                  55                  60                  

Glu Trp Ser Arg Ala Lys Pro His Glu Arg Ala Gln Val Leu Leu Arg 
65                  70                  75                  80  

Phe Ala Asp Glu Ile Val Ala His Ala Gln Glu Ile Ala Phe Leu Glu 
                85                  90                  95      

Ile Leu Thr Ser Gly Ala Thr Val Arg Arg Val Ser Asn Ala Asp Leu 
            100                 105                 110         

Leu Leu Ile Val Asp Leu Leu Gln Gln Thr Ala Arg Phe Ala Gln Ala 
        115                 120                 125             

Tyr Glu Tyr Ala Lys Thr Leu Pro Leu Arg Pro Phe Pro Gln Pro Ser 
    130                 135                 140                 

His Asn Gln Val Trp Arg Glu Pro Val Gly Val Cys Ala Gly Ile Thr 
145                 150                 155                 160 

Ala Trp Asn Tyr Pro Leu Leu Leu Ala Met Trp Lys Leu Ala Pro Ala 
                165                 170                 175     

Leu Ala Met Gly Asn Ser Ile Val Leu Lys Pro Ala Ser Asn Thr Pro 
            180                 185                 190         

Leu Ser Thr Leu Lys Leu Ala Glu Leu Ala Ala Lys Ala Gly Leu Pro 
        195                 200                 205             

Lys Gly Val Phe Asn Val Val Thr Gly Pro Gly Ser Ser Val Gly Glu 
    210                 215                 220                 

Ala Leu Val Thr His Pro Glu Val Asp Lys Ile Ala Phe Thr Gly Ser 
225                 230                 235                 240 

Thr Glu Val Gly Lys Arg Ile Met Gln Leu Ala Ala Gln Gly Val Lys 
                245                 250                 255     

Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Ala Ile Val Leu Pro 
            260                 265                 270         

Asp Ala Asp Leu Asp Leu Ala Ile Pro Gly Ile Leu Phe Gly Val Phe 
        275                 280                 285             

Leu His Ala Gly Gln Val Cys Glu Cys Gly Thr Arg Val Ile Val His 
    290                 295                 300                 

Glu Asp Ile Tyr Glu Glu Val Val Asn Arg Leu Ala Glu Met Ala Ser 
305                 310                 315                 320 

Gln Ile Lys Leu Gly Asn Pro Leu Asp Asp Lys Val Gly Met Gly Pro 
                325                 330                 335     

Ile Ile Ser Glu Ser Gln Met Asn Thr Ile Leu Ser Tyr Ile Glu Ser 
            340                 345                 350         

Gly Lys Ala Glu Gly Ala Arg Leu Val Cys Gly Gly Gln Arg Ala Thr 
        355                 360                 365             

Gly Gly Gly Leu Asp Ala Gly Tyr Phe Val Gln Pro Thr Ile Phe Ala 
    370                 375                 380                 

Asp Val Asp Asn Arg Met Lys Ile Ala Gln Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 

Val Leu Ala Val Met Lys Ala Arg Asp Val Asp Glu Ala Val Arg Leu 
                405                 410                 415     

Ala Asn Asp Thr Val Tyr Gly Leu Ala Gly Gly Val Trp Thr Arg Asp 
            420                 425                 430         

Leu Asn Gln Ala Tyr Arg Ile Ala Arg Glu Ile Arg Ala Gly Thr Ile 
        435                 440                 445             

Trp Val Asn Asp Trp His Met Phe Arg Ser Asp Ala Pro Phe Gly Gly 
    450                 455                 460                 

Tyr Lys Met Ser Gly Phe Gly Arg Glu Ile Gly Pro Tyr Ala Leu Asp 
465                 470                 475                 480 

Glu Tyr Thr Gln Leu Lys His Val His Ala Ser Phe Val His Glu Leu 
                485                 490                 495     

Glu Asn Arg His Trp Tyr Ser Ile Val Leu Pro Asp Arg Ala 
            500                 505                 510 

<210>   1236
<211>   510
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1225

<400>   1236
Met Val Met Thr Ser Val Arg Leu Pro Glu Tyr Gly Met Phe Ile Asp 
                5                   10                  15      

Gly Glu Tyr Thr Pro Ala Glu Ser Gly Glu Met Phe Glu Val Val Asn 
            20                  25                  30          

Pro Ala Thr Gly Gln Pro Cys Ala Arg Val Ala Lys Ser Asp Ala Arg 
        35                  40                  45              

Asp Val Asp Arg Ala Val Arg Ser Ala Arg Arg Ala Phe Glu Ser Gly 
    50                  55                  60                  

Glu Trp Ser Arg Ala Lys Pro His Glu Arg Ala Gln Val Leu Leu Arg 
65                  70                  75                  80  

Phe Ala Asp Glu Ile Val Ala His Ala Gln Glu Ile Ala Phe Leu Glu 
                85                  90                  95      

Ile Leu Thr Ser Gly Ala Thr Val Arg Arg Val Ser Asn Ala Asp Leu 
            100                 105                 110         

Leu Leu Ile Val Asp Leu Leu Gln Gln Thr Ala Arg Phe Ala Gln Ala 
        115                 120                 125             

Tyr Glu Tyr Ala Lys Thr Leu Pro Leu Arg Pro Phe Pro Gln Pro Ser 
    130                 135                 140                 

His Asn Gln Val Trp Arg Glu Pro Val Gly Val Cys Ala Gly Ile Thr 
145                 150                 155                 160 

Ala Trp Asn Tyr Pro Leu Ile Leu Ala Met Trp Lys Leu Ala Pro Ala 
                165                 170                 175     

Leu Ala Met Gly Asn Ser Ile Val Leu Lys Pro Ala Ser Asn Thr Pro 
            180                 185                 190         

Leu Ser Thr Leu Lys Leu Ala Glu Leu Ala Ala Lys Ala Gly Leu Pro 
        195                 200                 205             

Lys Gly Val Phe Asn Val Val Thr Gly Pro Gly Ser Ser Val Gly Glu 
    210                 215                 220                 

Ala Leu Val Thr His Pro Asp Val Asp Lys Ile Ala Phe Thr Gly Ser 
225                 230                 235                 240 

Thr Glu Val Gly Lys Arg Ile Met Gln Leu Ala Ala Gln Gly Val Lys 
                245                 250                 255     

Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Ala Ile Val Leu Pro 
            260                 265                 270         

Asp Ala Asp Leu Asp Leu Ala Ile Pro Gly Ile Leu Phe Gly Val Phe 
        275                 280                 285             

Leu His Ala Gly Gln Val Cys Glu Cys Gly Thr Arg Val Ile Val His 
    290                 295                 300                 

Glu Asp Ile Tyr Glu Glu Val Val Asn Arg Leu Ala Glu Met Ala Ser 
305                 310                 315                 320 

Gln Ile Lys Leu Gly Asn Pro Leu Asp Asp Lys Val Gly Met Gly Pro 
                325                 330                 335     

Ile Ile Ser Glu Ser Gln Met Asn Thr Ile Leu Ser Tyr Ile Glu Ser 
            340                 345                 350         

Gly Lys Ala Glu Gly Ala Arg Leu Val Cys Gly Gly Gln Arg Ala Thr 
        355                 360                 365             

Gly Gly Gly Leu Asp Ala Gly Tyr Phe Val Gln Pro Thr Ile Phe Ala 
    370                 375                 380                 

Asp Val Asp Asn Arg Met Lys Ile Ala Gln Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 

Val Leu Ala Val Met Lys Ala Arg Asp Val Asp Glu Ala Val Arg Leu 
                405                 410                 415     

Ala Asn Asp Thr Val Tyr Gly Leu Ala Gly Gly Val Trp Thr Arg Asp 
            420                 425                 430         

Leu Asn Gln Ala Tyr Arg Ile Ala Arg Glu Ile Arg Ala Gly Thr Ile 
        435                 440                 445             

Trp Val Asn Asp Trp His Met Phe Arg Ser Asp Ala Pro Phe Gly Gly 
    450                 455                 460                 

Tyr Lys Met Ser Gly Phe Gly Arg Glu Ile Gly Pro Tyr Ala Leu Asp 
465                 470                 475                 480 

Glu Tyr Thr Gln Leu Lys His Val His Ala Ser Phe Val His Glu Leu 
                485                 490                 495     

Glu Asn Arg His Trp Tyr Ser Ile Val Leu Pro Asp Arg Ala 
            500                 505                 510 

<210>   1237
<211>   1533
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1226

<400>   1237
atggtcatga cgagtgtgag actccccgag tacggcatgt tcatcgacgg cgagtacacg       60

cctgcggaaa gcggggagat gttcgaggtg gtgaatcccg ccacggggca gccctgcgcg      120

cgcgtggcga agtcggacgc gcgagacgtg gatcgcgccg tgcgaagcgc tcgcaaagcg      180

ttcgagtcgg gcgagtggtc ccgcgccaag ccccacgagc gggcccaggt gttgcttcgg      240

tttgcggacg agatcgtcgc gcacgcgcag gagattgcgt ttctggagat cttgacctcc      300

ggcgcgacgg tgcggcgcgt gtcgaacgcc gacttgcttc tcattgtcga tttgctccag      360

cagaccgcgc ggttcgcgca ggcgtacgaa tacgcgaaga cgcttccgct ccggccgttt      420

ccgcagccga gccacaacca ggtatggagg gagcccgtgg gcgtgtgcgc cgggatcacg      480

gcgtggaact atccactcat cctcgcgatg tggaagctcg cgcccgcgct cgccatgggg      540

aactccatcg tgttgaaacc ggcgtccaac acgccgcttt ccacgctcaa gcttgccgag      600

ctcgcggcga aggccgggct gccgaagggc gtgttcaacg tcgtcacggg gccaggatcg      660

tcggtgggcg aggcgctcgt cacgcacccg gaggtcgaca aaatcgcctt caccggatcc      720

accgaggtgg gcaagcggat catgcagctc gcggcgcagg gcgtcaagcg cgtgaccctg      780

gagttgggcg gcaagtcgcc ggccatcgtg ctgccggacg cggacctgga tctggcgata      840

cccggcatcc tgtttggcgt cttcctgcac gccgggcagg tgtgcgagtg cgggacgcgc      900

gtgattgtcc acgaggacat ctacgaggaa gtcgtgaatc gcctggccga gatggcctcg      960

cagatcaagc tcggcaatcc gctcgatgac aaggtgggca tggggcccat catctccgag     1020

tcgcagatga acaccattct gagctacatc gagtcgggca aggcggaagg cgcgcgcctc     1080

gtgtgcggcg gccagcgcgc cacgggaggc ggcctggacg caggttactt tgtgcagccg     1140

accatcttcg ccgacgtcga caaccgcatg aaaattgcgc aggaggagat cttcggcccc     1200

gtgctcgcgg tcatgaaggc gcgggacgtg gacgaggcgg ttcggctggc caacgatacc     1260

gtctatgggc tggcgggcgg cgtctggacg cgcgatctca accaggccta tcgcatcgcg     1320

cgcgagatcc gggcggggac catctgggtg aacgactggc acatgttccg cagcgacgcg     1380

ccgttcggcg gctacaagat gagcgggttc ggccgcgaga ttgggccgta cgcgctcgac     1440

gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc acgagctcga aaaccgccat     1500

tggtattcca ttgtgttgcc cgacagggcc tga                                  1533


<210>   1238
<211>   1533
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1226

<400>   1238
atggtcatga cgagtgtgag actccccgag tacggcatgt tcatcgacgg cgagtacacg       60

cctgcggaaa gcggggagat gttcgaggtg gtgaatcccg ccacggggca gccctgcgcg      120

cgcgtggcga agtcggacgc gcgagacgtg gatcgcgccg tgcgaagcgc tcgccgcgcg      180

ttcgagtcgg gcgagtggtc ccgcgccaag ccccacgagc gggcccaggt gttgcttcgg      240

tttgcggacg agatcgtcgc gcacgcgcag gagattgcgt ttctggagat cttgacctcc      300

ggcgcgacgg tgcggcgcgt gtcgaacgcc gacttgcttc tcattgtcga tttgctccag      360

cagaccgcgc ggttcgcgca ggcgtacgaa tacgcgaaga cgcttccgct caaaccgttt      420

ccgcagccga gccacaacca ggtatggagg gagcccgtgg gcgtgtgcgc cgggatcacg      480

gcgtggaact atccactcat cctcgcgatg tggaagctcg cgcccgcgct cgccatgggg      540

aactccatcg tgttgaaacc ggcgtccaac acgccgcttt ccacgctcaa gcttgccgag      600

ctcgcggcga aggccgggct gccgaagggc gtgttcaacg tcgtcacggg gccaggatcg      660

tcggtgggcg aggcgctcgt cacgcacccg gaggtcgaca aaatcgcctt caccggatcc      720

accgaggtgg gcaagcggat catgcagctc gcggcgcagg gcgtcaagcg cgtgaccctg      780

gagttgggcg gcaagtcgcc ggccatcgtg ctgccggacg cggacctgga tctggcgata      840

cccggcatcc tgtttggcgt cttcctgcac gccgggcagg tgtgcgagtg cgggacgcgc      900

gtgattgtcc acgaggacat ctacgaggaa gtcgtgaatc gcctggccga gatggcctcg      960

cagatcaagc tcggcaatcc gctcgatgac aaggtgggca tggggcccat catctccgag     1020

tcgcagatga acaccattct gagctacatc gagtcgggca aggcggaagg cgcgcgcctc     1080

gtgtgcggcg gccagcgcgc cacgggaggc ggcctggacg caggttactt tgtgcagccg     1140

accatcttcg ccgacgtcga caaccgcatg aaaattgcgc aggaggagat cttcggcccc     1200

gtgctcgcgg tcatgaaggc gcgggacgtg gacgaggcgg ttcggctggc caacgatacc     1260

gtctatgggc tggcgggcgg cgtctggacg cgcgatctca accaggccta tcgcatcgcg     1320

cgcgagatcc gggcggggac catctgggtg aacgactggc acatgttccg cagcgacgcg     1380

ccgttcggcg gctacaagat gagcgggttc ggccgcgaga ttgggccgta cgcgctcgac     1440

gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc acgagctcga aaaccgccat     1500

tggtattcca ttgtgttgcc cgacagggcc tga                                  1533


<210>   1239
<211>   1533
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1226

<400>   1239
atggtcatga cgagtgtgag actccccgag tacggcatgt tcatcgacgg cgagtacacg       60

cctgcggaaa gcggggagat gttcgaggtg gtgaatcccg ccacggggca gccctgcgcg      120

cgcgtggcga agtcggacgc gcgagacgtg gatcgcgccg tgcgaagcgc tcgccgcgcg      180

ttcgagtcgg gcgagtggtc ccgcgccaag ccccacgagc gggcccagat tttgcttcgg      240

tttgcggacg agatcgtcgc gcacgcgcag gagattgcgt ttctggagat cttgacctcc      300

ggcgcgacgg tgcggcgcgt gtcgaacgcc gacttgcttc tcattgtcga tttgctccag      360

cagaccgcgc ggttcgcgca ggcgtacgaa tacgcgaaga cgcttccgct ccggccgttt      420

ccgcagccga gccacaacca ggtatggagg gagcccgtgg gcgtgtgcgc cgggatcacg      480

gcgtggaact atccactcat cctcgcgatg tggaagctcg cgcccgcgct cgccatgggg      540

aactccatcg tgttgaaacc ggcgtccaac acgccgcttt ccacgctcaa gcttgccgag      600

ctcgcggcga aggccgggct gccgaagggc gtgttcaacg tcgtcacggg gccaggatcg      660

tcggtgggcg aggcgctcgt cacgcacccg gaggtcgaca aaatcgcctt caccggatcc      720

accgaggtgg gcaagcggat catgcagctc gcggcgcagg gcgtcaagcg cgtgaccctg      780

gagttgggcg gcaagtcgcc ggccatcgtg ctgccggacg cggacctgga tctggcgata      840

cccggcatcc tgtttggcgt cttcctgcac gccgggcagg tgtgcgagtg cgggacgcgc      900

gtgattgtcc acgaggacat ctacgaggaa gtcgtgaatc gcctggccga gatggcctcg      960

cagatcaagc tcggcaatcc gctcgatgac aaggtgggca tggggcccat catctccgag     1020

tcgcagatga acaccattct gagctacatc gagtcgggca aggcggaagg cgcgcgcctc     1080

gtgtgcggcg gccagcgcgc cacgggaggc ggcctggacg caggttactt tgtgcagccg     1140

accatcttcg ccgacgtcga caaccgcatg aaaattgcgc aggaggagat cttcggcccc     1200

gtgctcgcgg tcatgaaggc gcgggacgtg gacgaggcgg ttcggctggc caacgatacc     1260

gtctatgggc tggcgggcgg cgtctggacg cgcgatctca accaggccta tcgcatcgcg     1320

cgcgagatcc gggcggggac catctgggtg aacgactggc acatgttccg cagcgacgcg     1380

ccgttcggcg gctacaagat gagcgggttc ggccgcgaga ttgggccgta cgcgctcgac     1440

gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc acgagctcga aaaccgccat     1500

tggtattcca ttgtgttgcc cgacagggcc tga                                  1533


<210>   1240
<211>   1533
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1226

<400>   1240
atggtcatga cgagtgtgag actccccgag tacggcatgt tcatcgacgg cgagtacacg       60

cctgcggaaa gcggggagat gttcgaggtg gtgaatcccg ccacggggca gccctgcgcg      120

cgcgtggcga agtcggacgc gcgagacgtg gatcgcgccg tgcgaagcgc tcgccgcgcg      180

ttcgagtcgg gcgagtggtc ccgcgccaag ccccacgagc gggcccaggt gttgcttcgg      240

tttgcggacg agatcgtcgc gcacgcgcag gagattgcgt ttctggagat cttgacctcc      300

ggcgcgacgg tgcggcgcgt gtcgaacgcc gacttgcttc tcattgtcga tttgctccag      360

cagaccgcgc ggttcgcgca ggcgtacgaa tacgcgaaga cgcttccgct ccggccgttt      420

ccgcagccga gccacaacca ggtatggagg gagcccgtgg gcgtgtgcgc cgggatcacg      480

gcgtggaact atccactctt actcgcgatg tggaagctcg cgcccgcgct cgccatgggg      540

aactccatcg tgttgaaacc ggcgtccaac acgccgcttt ccacgctcaa gcttgccgag      600

ctcgcggcga aggccgggct gccgaagggc gtgttcaacg tcgtcacggg gccaggatcg      660

tcggtgggcg aggcgctcgt cacgcacccg gaggtcgaca aaatcgcctt caccggatcc      720

accgaggtgg gcaagcggat catgcagctc gcggcgcagg gcgtcaagcg cgtgaccctg      780

gagttgggcg gcaagtcgcc ggccatcgtg ctgccggacg cggacctgga tctggcgata      840

cccggcatcc tgtttggcgt cttcctgcac gccgggcagg tgtgcgagtg cgggacgcgc      900

gtgattgtcc acgaggacat ctacgaggaa gtcgtgaatc gcctggccga gatggcctcg      960

cagatcaagc tcggcaatcc gctcgatgac aaggtgggca tggggcccat catctccgag     1020

tcgcagatga acaccattct gagctacatc gagtcgggca aggcggaagg cgcgcgcctc     1080

gtgtgcggcg gccagcgcgc cacgggaggc ggcctggacg caggttactt tgtgcagccg     1140

accatcttcg ccgacgtcga caaccgcatg aaaattgcgc aggaggagat cttcggcccc     1200

gtgctcgcgg tcatgaaggc gcgggacgtg gacgaggcgg ttcggctggc caacgatacc     1260

gtctatgggc tggcgggcgg cgtctggacg cgcgatctca accaggccta tcgcatcgcg     1320

cgcgagatcc gggcggggac catctgggtg aacgactggc acatgttccg cagcgacgcg     1380

ccgttcggcg gctacaagat gagcgggttc ggccgcgaga ttgggccgta cgcgctcgac     1440

gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc acgagctcga aaaccgccat     1500

tggtattcca ttgtgttgcc cgacagggcc tga                                  1533


<210>   1241
<211>   1533
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1226

<400>   1241
atggtcatga cgagtgtgag actccccgag tacggcatgt tcatcgacgg cgagtacacg       60

cctgcggaaa gcggggagat gttcgaggtg gtgaatcccg ccacggggca gccctgcgcg      120

cgcgtggcga agtcggacgc gcgagacgtg gatcgcgccg tgcgaagcgc tcgccgcgcg      180

ttcgagtcgg gcgagtggtc ccgcgccaag ccccacgagc gggcccaggt gttgcttcgg      240

tttgcggacg agatcgtcgc gcacgcgcag gagattgcgt ttctggagat cttgacctcc      300

ggcgcgacgg tgcggcgcgt gtcgaacgcc gacttgcttc tcattgtcga tttgctccag      360

cagaccgcgc ggttcgcgca ggcgtacgaa tacgcgaaga cgcttccgct ccggccgttt      420

ccgcagccga gccacaacca ggtatggagg gagcccgtgg gcgtgtgcgc cgggatcacg      480

gcgtggaact atccactcat cctcgcgatg tggaagctcg cgcccgcgct cgccatgggg      540

aactccatcg tgttgaaacc ggcgtccaac acgccgcttt ccacgctcaa gcttgccgag      600

ctcgcggcga aggccgggct gccgaagggc gtgttcaacg tcgtcacggg gccaggatcg      660

tcggtgggcg aggcgctcgt cacgcacccg gatgtcgaca aaatcgcctt caccggatcc      720

accgaggtgg gcaagcggat catgcagctc gcggcgcagg gcgtcaagcg cgtgaccctg      780

gagttgggcg gcaagtcgcc ggccatcgtg ctgccggacg cggacctgga tctggcgata      840

cccggcatcc tgtttggcgt cttcctgcac gccgggcagg tgtgcgagtg cgggacgcgc      900

gtgattgtcc acgaggacat ctacgaggaa gtcgtgaatc gcctggccga gatggcctcg      960

cagatcaagc tcggcaatcc gctcgatgac aaggtgggca tggggcccat catctccgag     1020

tcgcagatga acaccattct gagctacatc gagtcgggca aggcggaagg cgcgcgcctc     1080

gtgtgcggcg gccagcgcgc cacgggaggc ggcctggacg caggttactt tgtgcagccg     1140

accatcttcg ccgacgtcga caaccgcatg aaaattgcgc aggaggagat cttcggcccc     1200

gtgctcgcgg tcatgaaggc gcgggacgtg gacgaggcgg ttcggctggc caacgatacc     1260

gtctatgggc tggcgggcgg cgtctggacg cgcgatctca accaggccta tcgcatcgcg     1320

cgcgagatcc gggcggggac catctgggtg aacgactggc acatgttccg cagcgacgcg     1380

ccgttcggcg gctacaagat gagcgggttc ggccgcgaga ttgggccgta cgcgctcgac     1440

gaatacacgc agctcaagca cgtacacgcg tcgttcgtgc acgagctcga aaaccgccat     1500

tggtattcca ttgtgttgcc cgacagggcc tga                                  1533


<210>   1242
<211>   361
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1242
Met Thr Met Leu Ser Gln Val Val Ala Arg Phe Glu Ile Pro Tyr Val 
                5                   10                  15      

Gln Ile Val Asp Glu Asn Gly Asn Val Val Asn Pro Asp Leu Val Pro 
            20                  25                  30          

Glu Leu Ser Asp Asp Asp Leu Arg Glu Leu Met Lys Arg Met Val Phe 
        35                  40                  45              

Thr Arg Ile Trp Asp Gln Arg Ala Ile Arg Leu Ser Arg Gln Gly Arg 
    50                  55                  60                  

Leu Gly Phe Tyr Ala Pro Val Ser Gly Gln Glu Ala Ser Met Ile Gly 
65                  70                  75                  80  

Ser Glu Phe Ala Thr Lys Lys Glu Asp Phe Leu Leu Pro Gly Tyr Arg 
                85                  90                  95      

Asp Ile Pro Gln Leu Tyr Phe His Gly Tyr Pro Leu His Gln Leu Phe 
            100                 105                 110         

Leu Tyr Ser Arg Gly His Gln Leu Gly Gly Lys Val Pro Glu Gly Val 
        115                 120                 125             

Asn Cys Met Val Pro Gln Ile Ile Ile Gly Ala Gln Ile Val Gln Ala 
    130                 135                 140                 

Ala Gly Val Gly Leu Ala Phe Lys Leu Arg Gly Glu Lys Arg Val Ala 
145                 150                 155                 160 

Val Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln Gly Asp Phe Tyr Glu 
                165                 170                 175     

Gly Met Asn Phe Ala Gly Ala Met Asn Leu Pro Val Val Phe Phe Val 
            180                 185                 190         

Gln Asn Asn Gln Tyr Ala Ile Ser Val Pro Arg Glu Leu Gln Thr Arg 
        195                 200                 205             

Ala Gln Thr Leu Ala Gln Lys Ala Ile Ala Ala Gly Ile Pro Gly Val 
    210                 215                 220                 

Gln Val Asp Gly Met Asp Val Leu Ala Val Tyr His Val Met His Glu 
225                 230                 235                 240 

Ala Leu Glu Arg Ala Arg Asn Gly Glu Gly Pro Thr Met Ile Glu Ala 
                245                 250                 255     

Val Thr Phe Arg Tyr Gly Pro His Thr Met Ser Gly Asp Asp Pro Thr 
            260                 265                 270         

Arg Tyr Arg Thr Lys Asp Val Gln Glu Glu Trp Glu Lys Lys Asp Pro 
        275                 280                 285             

Leu Ile Arg Phe Arg Lys Tyr Leu Glu Glu Lys Gly Leu Trp Ser Gln 
    290                 295                 300                 

Glu Glu Glu Glu Ala Tyr Ile Glu Glu Ala Lys Glu Thr Val Asn Asn 
305                 310                 315                 320 

Ala Leu Lys Glu Ala Asp Ala Ala Glu Lys Met Thr Ile Pro Gly Leu 
                325                 330                 335     

Ile Asp Ser Met Phe Glu Glu Leu Thr Pro Thr Leu Lys Arg Gln Arg 
            340                 345                 350         

Ala Glu Phe Ala Gly Glu Glu Ala Asn 
        355                 360     

<210>   1243
<211>   1086
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1243
gtgaccatgt tgagccaggt ggttgctcgt tttgagatcc cgtacgtcca aatcgtggac       60

gagaacggga acgtcgtgaa ccctgacctg gtcccggagt tgtcggacga cgacctgcgc      120

gagctcatga agcgcatggt cttcacgcgc atctgggatc aacgcgcaat tcgcctgtcc      180

cggcagggac gcctgggctt ttacgcgccg gtgtccggcc aggaagcgtc catgatcggc      240

agcgagttcg ccacgaagaa agaggacttc ctgctcccgg gctatcgcga catcccgcag      300

ctgtacttcc acgggtatcc gctgcatcag ctcttccttt actcccgcgg acatcagctt      360

ggcggcaaag ttcctgaagg cgtcaactgt atggtgccgc agatcatcat cggagcgcaa      420

atcgtccagg cggcgggcgt cggcctcgcg ttcaagctgc gcggtgaaaa gcgcgtggcg      480

gtcacgtaca cgggcgacgg cggcacgagc cagggcgact tttacgaagg catgaacttc      540

gcgggcgcca tgaatctccc cgtggtgttc tttgttcaga acaaccagta cgccatttct      600

gtgcctcgcg agcttcagac tcgtgcgcag acgctcgctc agaaggccat cgcggccggc      660

atccccggcg tgcaagtcga cggcatggac gtgttggccg tgtaccacgt gatgcacgaa      720

gcccttgagc gcgcgcgcaa cggcgagggc ccaaccatga ttgaggccgt gaccttccgc      780

tacggccccc acacgatgtc gggcgacgat ccgacccgtt atcgcacgaa ggacgtgcag      840

gaagagtggg agaagaagga tccgctcatc cgcttccgca agtacctcga ggaaaaggga      900

ctttggtctc aagaagagga agaggcttac atcgaggagg ccaaggagac ggtcaacaac      960

gccctcaagg aggcggatgc ggcggagaag atgaccatcc cgggtctcat cgactcgatg     1020

ttcgaagaac tcaccccgac gctcaagcgc cagcgggcgg aatttgccgg cgaggaggcg     1080

aactga                                                                1086


<210>   1244
<211>   355
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1244
Leu Glu Lys Val Glu Gly Gln Phe Glu Thr Phe Gln Ile Leu Asn Glu 
                5                   10                  15      

Glu Gly Glu Val Val Asn Glu Ala Ala Met Pro Asp Leu Ser Asp Glu 
            20                  25                  30          

Gln Leu Gln Glu Leu Met Lys Arg Met Val Tyr Thr Arg Ile Trp Asp 
        35                  40                  45              

Gln Arg Ala Ile Ser Leu Asn Arg Gln Gly Arg Leu Gly Phe Tyr Ala 
    50                  55                  60                  

Pro Val Ala Gly Gln Glu Ala Ser Met Leu Gly Ser Gln Phe Ala Leu 
65                  70                  75                  80  

Asp Lys Glu Asp Trp Ile Leu Pro Gly Tyr Arg Asp Ile Pro Gln Ile 
                85                  90                  95      

Val Phe His Gly Leu Pro Leu Tyr Gln Ala Phe Leu Tyr Ser Arg Gly 
            100                 105                 110         

His Phe Glu Gly Gly Gln Ile Pro Asp Gly Val Asn Val Leu Met Pro 
        115                 120                 125             

Gln Ile Ile Ile Gly Ala Gln Ile Val Gln Ala Ala Gly Val Ala Met 
    130                 135                 140                 

Gly Leu Lys Arg Lys Gly Lys Gln Asn Val Ala Ile Thr Tyr Thr Gly 
145                 150                 155                 160 

Asp Gly Gly Ala Ser Gln Gly Asp Phe Tyr Glu Gly Met Asn Phe Ala 
                165                 170                 175     

Gly Ala Tyr Asn Ser Pro Ala Ile Phe Val Val Gln Asn Asn Arg Phe 
            180                 185                 190         

Ala Ile Ser Val Pro Val Glu Lys Gln Ser Ala Ala Lys Thr Ile Ala 
        195                 200                 205             

Gln Lys Ala Val Ala Ala Gly Ile Glu Gly Ile Gln Val Asp Gly Met 
    210                 215                 220                 

Asp Val Leu Ala Val Tyr Ala Ala Thr Lys Gln Ala Arg Glu Arg Ala 
225                 230                 235                 240 

Leu Ala Gly Asp Gly Pro Thr Leu Ile Glu Thr Leu Cys Tyr Arg Tyr 
                245                 250                 255     

Gly Pro His Thr Met Ala Gly Asp Asp Pro Thr Arg Tyr Arg Ser Ser 
            260                 265                 270         

Asp Leu Asp Asp Glu Trp Glu Lys Lys Asp Pro Leu Val Arg Phe Arg 
        275                 280                 285             

Lys Phe Leu Glu Gly Lys Gly Leu Trp Ser Glu Glu Gln Glu Asn Glu 
    290                 295                 300                 

Val Val Glu Lys Ala Lys Glu Asp Ile Lys Ala Ala Ile Lys Lys Ala 
305                 310                 315                 320 

Asp Ala Ala Pro Lys Gln Lys Val Thr Asp Leu Ile Gly Phe Met Phe 
                325                 330                 335     

Glu Glu Ala Pro Gln His Leu Arg Glu Gln Leu Glu Glu Tyr Thr Ala 
            340                 345                 350         

Lys Glu Ser 
        355 

<210>   1245
<211>   349
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   1245
Gln Phe Pro Thr Phe Gln Ile Leu Asn Glu Glu Gly Glu Val Val Asn 
                5                   10                  15      

Glu Glu Ala Met Pro Glu Leu Ser Asp Glu Gln Leu Lys Glu Leu Met 
            20                  25                  30          

Arg Arg Met Val Tyr Thr Arg Ile Leu Asp Gln Arg Ser Ile Ser Leu 
        35                  40                  45              

Asn Arg Gln Gly Arg Leu Gly Phe Tyr Ala Pro Thr Ala Gly Gln Glu 
    50                  55                  60                  

Ala Ser Gln Ile Ala Ser His Phe Ala Leu Glu Lys Glu Asp Phe Ile 
65                  70                  75                  80  

Leu Pro Gly Tyr Arg Asp Val Pro Gln Ile Ile Trp His Gly Leu Pro 
                85                  90                  95      

Leu Tyr Gln Ala Phe Leu Phe Ser Arg Gly His Phe His Gly Asn Gln 
            100                 105                 110         

Ile Pro Glu Gly Val Asn Val Leu Pro Pro Gln Ile Ile Ile Gly Ala 
        115                 120                 125             

Gln Tyr Ile Gln Ala Ala Gly Val Ala Leu Gly Leu Lys Met Arg Gly 
    130                 135                 140                 

Lys Lys Ala Val Ala Ile Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln 
145                 150                 155                 160 

Gly Asp Phe Tyr Glu Gly Ile Asn Phe Ala Gly Ala Phe Lys Ala Pro 
                165                 170                 175     

Ala Ile Phe Val Val Gln Asn Asn Arg Phe Ala Ile Ser Thr Pro Val 
            180                 185                 190         

Glu Lys Gln Thr Val Ala Lys Thr Leu Ala Gln Lys Ala Val Ala Ala 
        195                 200                 205             

Gly Ile Pro Gly Ile Gln Val Asp Gly Met Asp Pro Leu Ala Val Tyr 
    210                 215                 220                 

Ala Ala Val Lys Ala Ala Arg Glu Arg Ala Ile Asn Gly Glu Gly Pro 
225                 230                 235                 240 

Thr Leu Ile Glu Thr Leu Cys Phe Arg Tyr Gly Pro His Thr Met Ser 
                245                 250                 255     

Gly Asp Asp Pro Thr Arg Tyr Arg Ser Lys Glu Leu Glu Asn Glu Trp 
            260                 265                 270         

Ala Lys Lys Asp Pro Leu Val Arg Phe Arg Lys Phe Leu Glu Ala Lys 
        275                 280                 285             

Gly Leu Trp Ser Glu Glu Glu Glu Asn Asn Val Ile Glu Gln Ala Lys 
    290                 295                 300                 

Glu Glu Ile Lys Glu Ala Ile Lys Lys Ala Asp Glu Thr Pro Lys Gln 
305                 310                 315                 320 

Lys Val Thr Asp Leu Ile Ser Ile Met Phe Glu Glu Leu Pro Phe Asn 
                325                 330                 335     

Leu Lys Glu Gln Tyr Glu Ile Tyr Lys Glu Lys Glu Ser 
            340                 345                 

<210>   1246
<211>   349
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   1246
Gln Phe Pro Thr Phe Gln Ile Leu Asn Glu Glu Gly Glu Val Val Asn 
                5                   10                  15      

Glu Glu Ala Met Pro Glu Leu Ser Asp Glu Gln Leu Lys Glu Leu Met 
            20                  25                  30          

Arg Arg Met Val Tyr Thr Arg Ile Leu Asp Gln Arg Ser Ile Ser Leu 
        35                  40                  45              

Asn Arg Gln Gly Arg Leu Gly Phe Tyr Ala Pro Thr Ala Gly Gln Glu 
    50                  55                  60                  

Ala Ser Gln Ile Ala Ser His Phe Ala Leu Glu Lys Glu Asp Phe Ile 
65                  70                  75                  80  

Leu Pro Gly Tyr Arg Asp Val Pro Gln Ile Ile Trp His Gly Leu Pro 
                85                  90                  95      

Leu Tyr Gln Ala Phe Leu Phe Ser Arg Gly His Phe His Gly Asn Gln 
            100                 105                 110         

Ile Pro Glu Gly Val Asn Val Leu Pro Pro Gln Ile Ile Ile Gly Ala 
        115                 120                 125             

Gln Tyr Ile Gln Ala Ala Gly Val Ala Leu Gly Leu Lys Met Arg Gly 
    130                 135                 140                 

Lys Lys Ala Val Ala Ile Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln 
145                 150                 155                 160 

Gly Asp Phe Tyr Glu Gly Ile Asn Phe Ala Gly Ala Phe Lys Ala Pro 
                165                 170                 175     

Ala Ile Phe Val Val Gln Asn Asn Arg Phe Ala Ile Ser Thr Pro Val 
            180                 185                 190         

Glu Lys Gln Thr Val Ala Lys Thr Leu Ala Gln Lys Ala Val Ala Ala 
        195                 200                 205             

Gly Ile Pro Gly Ile Gln Val Asp Gly Met Asp Pro Leu Ala Val Tyr 
    210                 215                 220                 

Ala Ala Val Lys Ala Ala Arg Glu Arg Ala Ile Asn Gly Glu Gly Pro 
225                 230                 235                 240 

Thr Leu Ile Glu Thr Leu Cys Phe Arg Tyr Gly Pro His Thr Met Ser 
                245                 250                 255     

Gly Asp Asp Pro Thr Arg Tyr Arg Ser Lys Glu Leu Glu Asn Glu Trp 
            260                 265                 270         

Ala Lys Lys Asp Pro Leu Val Arg Phe Arg Lys Phe Leu Glu Ala Lys 
        275                 280                 285             

Gly Leu Trp Ser Glu Glu Glu Glu Asn Asn Val Ile Glu Gln Ala Lys 
    290                 295                 300                 

Glu Glu Ile Lys Glu Ala Ile Lys Lys Ala Asp Glu Thr Pro Lys Gln 
305                 310                 315                 320 

Lys Val Thr Asp Leu Ile Ser Ile Met Phe Glu Glu Leu Pro Phe Asn 
                325                 330                 335     

Leu Lys Glu Gln Tyr Glu Ile Tyr Lys Glu Lys Glu Ser 
            340                 345                 

<210>   1247
<211>   344
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   1247
Gln Ile Leu Asn Ala Glu Gly Glu Val Val Asn Lys Asp Ala Met Pro 
                5                   10                  15      

Asp Leu Ser Asp Asp Gln Leu Lys Glu Leu Met Arg Arg Met Val Tyr 
            20                  25                  30          

Ile Arg Ile Leu Asp Gln Arg Ser Ile Ser Leu Ser Arg Gln Gly Arg 
        35                  40                  45              

Leu Gly Phe Tyr Ala Pro Thr Ala Gly Gln Glu Ala Ser Gln Ile Ala 
    50                  55                  60                  

Ser His Phe Ala Leu Glu Gln Asp Asp Phe Ile Leu Pro Gly Tyr Arg 
65                  70                  75                  80  

Asp Val Pro Gln Leu Ile Trp His Gly Leu Pro Leu His Gln Ala Phe 
                85                  90                  95      

Leu Phe Ser Arg Gly His Phe Lys Gly Asn Gln Met Pro Glu Gly Val 
            100                 105                 110         

Asn Ala Leu Ser Pro Gln Ile Ile Ile Gly Ala Gln Ile Ile Gln Thr 
        115                 120                 125             

Ala Gly Val Ala Leu Gly Leu Lys Lys Arg Gly Lys Lys Ala Val Ala 
    130                 135                 140                 

Ile Thr Tyr Thr Gly Asp Gly Gly Ala Ser Gln Gly Asp Phe Tyr Glu 
145                 150                 155                 160 

Gly Met Asn Phe Ala Gly Ala Phe Lys Ala Pro Ala Ile Phe Val Val 
                165                 170                 175     

Gln Asn Asn Arg Tyr Ala Ile Ser Thr Pro Val Glu Lys Gln Ser Ser 
            180                 185                 190         

Ala Gln Thr Ile Ala Gln Lys Ala Val Ala Val Gly Ile Thr Gly Val 
        195                 200                 205             

Gln Val Asp Gly Met Asp Ala Leu Ala Val Tyr Ala Ala Thr Ala Glu 
    210                 215                 220                 

Ala Arg Gln Arg Ala Ile Asn Gly Glu Gly Pro Thr Leu Ile Glu Thr 
225                 230                 235                 240 

Leu Thr Phe Arg Tyr Gly Pro His Thr Met Ser Gly Asp Asp Pro Thr 
                245                 250                 255     

Lys Tyr Arg Thr Lys Glu Ile Glu Asn Glu Trp Glu Gln Lys Asp Pro 
            260                 265                 270         

Leu Val Arg Phe Arg Lys Phe Leu Glu Asn Lys Gly Leu Trp Ser Glu 
        275                 280                 285             

Glu Glu Glu Asn Lys Val Ile Glu Gln Ala Lys Glu Glu Ile Lys Gln 
    290                 295                 300                 

Ala Ile Lys Lys Ala Asp Gly Glu Ser Lys Pro Lys Val Thr Glu Leu 
305                 310                 315                 320 

Ile Glu Asn Met Phe Glu Glu Pro Thr Phe Asn Leu Lys Glu Gln Leu 
                325                 330                 335     

Glu Ile Tyr Lys Ala Lys Glu Ser 
            340                 

<210>   1248
<211>   349
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1248
Gln Phe Pro Thr Phe Gln Ile Leu Asn Glu Glu Gly Glu Ile Val Asn 
                5                   10                  15      

Glu Glu Ala Met Pro Glu Leu Ser Asp Glu Gln Leu Lys Glu Leu Met 
            20                  25                  30          

Arg Arg Met Val Tyr Thr Arg Ile Leu Asp Gln Arg Ser Ile Ser Leu 
        35                  40                  45              

Asn Arg Gln Gly Arg Leu Gly Phe Tyr Ala Pro Thr Ala Gly Gln Glu 
    50                  55                  60                  

Ala Ser Gln Ile Ala Ser His Phe Ala Leu Glu Lys Glu Asp Phe Ile 
65                  70                  75                  80  

Leu Pro Gly Tyr Arg Asp Val Pro Gln Ile Ile Trp His Gly Leu Pro 
                85                  90                  95      

Leu Tyr Gln Ala Phe Leu Phe Ser Arg Gly His Phe His Gly Asn Gln 
            100                 105                 110         

Ile Pro Glu Gly Val Asn Val Leu Pro Pro Gln Ile Ile Ile Gly Ala 
        115                 120                 125             

Gln Tyr Ile Gln Ala Ala Gly Val Ala Leu Gly Leu Lys Met Arg Gly 
    130                 135                 140                 

Lys Lys Ala Val Ala Ile Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln 
145                 150                 155                 160 

Gly Asp Phe Tyr Glu Gly Ile Asn Phe Ala Gly Ala Phe Lys Ala Pro 
                165                 170                 175     

Ala Ile Phe Val Val Gln Asn Asn Arg Phe Ala Ile Ser Thr Pro Val 
            180                 185                 190         

Glu Lys Gln Thr Ile Ala Lys Thr Leu Ala Gln Lys Ala Val Ala Ala 
        195                 200                 205             

Gly Ile Pro Gly Ile Gln Val Asp Gly Met Asp Pro Leu Ala Val Tyr 
    210                 215                 220                 

Ala Ala Val Lys Ala Ala Arg Glu Arg Ala Ile Asn Gly Glu Gly Pro 
225                 230                 235                 240 

Ala Leu Ile Glu Thr Leu Cys Phe Arg Tyr Gly Pro His Thr Met Ser 
                245                 250                 255     

Gly Asp Asp Pro Thr Arg Tyr Arg Ser Lys Glu Leu Glu Asn Glu Trp 
            260                 265                 270         

Ala Lys Lys Asp Pro Leu Val Arg Phe Arg Lys Phe Leu Glu Ala Lys 
        275                 280                 285             

Gly Leu Trp Ser Glu Glu Glu Glu Asn Arg Val Ile Glu Gln Ala Lys 
    290                 295                 300                 

Glu Asp Ile Lys Glu Ala Ile Lys Lys Ala Asp Glu Thr Pro Lys Gln 
305                 310                 315                 320 

Lys Val Thr Asp Leu Ile Ser Ile Met Phe Glu Glu Leu Pro Ala Asn 
                325                 330                 335     

Leu Lys Glu Gln Tyr Glu Ile Tyr Lys Glu Lys Glu Ser 
            340                 345                 

<210>   1249
<211>   361
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1242

<400>   1249
Met Thr Met Leu Ser Gln Val Val Ala Arg Phe Glu Ile Pro Tyr Val 
                5                   10                  15      

Gln Ile Val Asp Glu Asn Gly Asn Val Val Asn Pro Asp Leu Val Pro 
            20                  25                  30          

Glu Leu Ser Asp Asp Asp Leu Arg Glu Leu Met Lys Arg Met Val Phe 
        35                  40                  45              

Thr Arg Ile Trp Asp Gln Arg Ala Ile Arg Leu Ser Arg Gln Gly Arg 
    50                  55                  60                  

Leu Gly Phe Tyr Ala Pro Val Ser Gly Gln Glu Ala Ser Met Ile Gly 
65                  70                  75                  80  

Ser Glu Phe Ala Thr Lys Lys Glu Asp Phe Leu Leu Pro Gly Tyr Arg 
                85                  90                  95      

Asp Ile Pro Gln Leu Tyr Phe His Gly Tyr Pro Leu His Gln Leu Phe 
            100                 105                 110         

Leu Tyr Ser Arg Gly His Gln Leu Gly Gly Lys Val Pro Glu Gly Val 
        115                 120                 125             

Asn Cys Met Val Pro Gln Ile Ile Ile Gly Ala Gln Ile Val Gln Ala 
    130                 135                 140                 

Ala Gly Val Gly Leu Ala Phe Lys Leu Arg Gly Glu Lys Arg Val Ala 
145                 150                 155                 160 

Val Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln Gly Asp Phe Tyr Glu 
                165                 170                 175     

Gly Met Asn Phe Ala Gly Ala Met Asn Leu Pro Val Val Phe Phe Val 
            180                 185                 190         

Gln Asn Asn Gln Tyr Ala Ile Ser Val Pro Arg Glu Leu Gln Thr Arg 
        195                 200                 205             

Ala Gln Thr Leu Ala Gln Lys Ala Ile Ala Ala Gly Ile Pro Gly Val 
    210                 215                 220                 

Gln Val Asp Gly Met Asp Val Leu Ala Val Tyr His Val Met His Glu 
225                 230                 235                 240 

Ala Leu Glu Arg Ala Arg Asn Gly Glu Gly Pro Thr Met Ile Glu Ala 
                245                 250                 255     

Val Thr Phe Arg Tyr Gly Pro His Thr Met Ser Gly Asp Asp Pro Thr 
            260                 265                 270         

Arg Tyr Arg Thr Lys Asp Val Gln Glu Glu Trp Glu Lys Lys Asp Pro 
        275                 280                 285             

Leu Ile Arg Phe Arg Lys Tyr Leu Glu Glu Lys Gly Leu Trp Ser Gln 
    290                 295                 300                 

Glu Glu Glu Glu Ala Tyr Ile Glu Glu Ala Lys Glu Thr Val Asn Asn 
305                 310                 315                 320 

Ala Leu Lys Glu Ala Asp Ala Ala Glu Lys Met Thr Ile Pro Gly Leu 
                325                 330                 335     

Ile Glu Ser Met Phe Glu Glu Leu Thr Pro Thr Leu Lys Arg Gln Arg 
            340                 345                 350         

Ala Glu Phe Ala Gly Glu Glu Ala Asn 
        355                 360     

<210>   1250
<211>   361
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1242

<400>   1250
Met Thr Met Leu Ser Gln Val Val Ala Arg Phe Glu Ile Pro Tyr Val 
                5                   10                  15      

Gln Ile Val Asp Glu Asn Gly Asn Val Val Asn Pro Asp Leu Val Pro 
            20                  25                  30          

Glu Leu Ser Asp Asp Asp Leu Arg Glu Leu Met Lys Arg Met Val Phe 
        35                  40                  45              

Thr Arg Ile Trp Asp Gln Arg Ala Ile Arg Leu Ser Arg Gln Gly Arg 
    50                  55                  60                  

Leu Gly Phe Tyr Ala Pro Val Ser Gly Gln Glu Ala Ser Met Ile Gly 
65                  70                  75                  80  

Ser Glu Phe Ala Thr Lys Lys Glu Asp Phe Leu Leu Pro Gly Tyr Arg 
                85                  90                  95      

Asp Ile Pro Gln Leu Tyr Phe His Gly Tyr Pro Leu His Gln Leu Phe 
            100                 105                 110         

Leu Tyr Ser Arg Gly His Gln Leu Gly Gly Lys Val Pro Glu Gly Val 
        115                 120                 125             

Asn Cys Met Val Pro Gln Ile Ile Ile Gly Ala Gln Ile Val Gln Ala 
    130                 135                 140                 

Ala Gly Val Gly Leu Ala Phe Lys Leu Arg Gly Glu Lys Arg Val Ala 
145                 150                 155                 160 

Val Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln Gly Asp Phe Tyr Glu 
                165                 170                 175     

Gly Met Asn Phe Ala Gly Ala Met Asn Leu Pro Val Val Phe Phe Val 
            180                 185                 190         

Gln Asn Asn Gln Tyr Ala Ile Ser Val Pro Arg Glu Leu Gln Thr Arg 
        195                 200                 205             

Ala Gln Thr Leu Ala Gln Lys Ala Ile Ala Ala Gly Ile Pro Gly Val 
    210                 215                 220                 

Gln Val Asp Gly Met Asp Val Leu Ala Val Tyr His Val Met His Glu 
225                 230                 235                 240 

Ala Leu Glu Arg Ala Arg Asn Gly Glu Gly Pro Thr Met Ile Glu Ala 
                245                 250                 255     

Val Thr Phe Arg Tyr Gly Pro His Thr Met Ser Gly Asp Asp Pro Thr 
            260                 265                 270         

Arg Tyr Arg Thr Lys Asp Val Gln Glu Glu Trp Glu Lys Lys Asp Pro 
        275                 280                 285             

Leu Ile Arg Phe Arg Lys Tyr Leu Glu Asp Lys Gly Leu Trp Ser Gln 
    290                 295                 300                 

Glu Glu Glu Glu Ala Tyr Ile Glu Glu Ala Lys Glu Thr Val Asn Asn 
305                 310                 315                 320 

Ala Leu Lys Glu Ala Asp Ala Ala Glu Lys Met Thr Ile Pro Gly Leu 
                325                 330                 335     

Ile Asp Ser Met Phe Glu Glu Leu Thr Pro Thr Leu Lys Arg Gln Arg 
            340                 345                 350         

Ala Glu Phe Ala Gly Glu Glu Ala Asn 
        355                 360     

<210>   1251
<211>   361
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1242

<400>   1251
Met Thr Met Leu Ser Gln Val Val Ala Arg Phe Glu Ile Pro Tyr Val 
                5                   10                  15      

Gln Ile Val Asp Glu Asn Gly Asn Val Val Asn Pro Asp Leu Val Pro 
            20                  25                  30          

Glu Leu Ser Asp Asp Asp Leu Arg Glu Leu Met Lys Arg Met Val Phe 
        35                  40                  45              

Thr Arg Ile Trp Asp Gln Arg Ala Ile Arg Leu Ser Arg Gln Gly Arg 
    50                  55                  60                  

Leu Gly Phe Tyr Ala Pro Val Ser Gly Gln Glu Ala Ser Met Ile Gly 
65                  70                  75                  80  

Ser Glu Phe Ala Thr Lys Lys Glu Asp Phe Leu Leu Pro Gly Tyr Arg 
                85                  90                  95      

Asp Ile Pro Gln Leu Tyr Phe His Gly Tyr Pro Leu His Gln Leu Phe 
            100                 105                 110         

Leu Tyr Ser Arg Gly His Gln Leu Gly Gly Lys Val Pro Glu Gly Val 
        115                 120                 125             

Asn Cys Met Val Pro Gln Ile Ile Ile Gly Ala Gln Ile Val Gln Ala 
    130                 135                 140                 

Ala Gly Val Gly Leu Ala Phe Lys Leu Arg Gly Glu Lys Arg Val Ala 
145                 150                 155                 160 

Val Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln Gly Asp Phe Tyr Glu 
                165                 170                 175     

Gly Met Asn Phe Ala Gly Ala Met Asn Leu Pro Val Val Phe Phe Val 
            180                 185                 190         

Gln Asn Asn Gln Tyr Ala Ile Ser Val Pro Arg Glu Leu Gln Thr Arg 
        195                 200                 205             

Ala Gln Thr Leu Ala Gln Lys Ala Ile Ala Ala Gly Ile Pro Gly Val 
    210                 215                 220                 

Gln Val Asp Gly Met Asp Val Leu Ala Val Tyr His Val Met His Glu 
225                 230                 235                 240 

Ala Leu Glu Arg Ala Lys Asn Gly Glu Gly Pro Thr Met Ile Glu Ala 
                245                 250                 255     

Val Thr Phe Arg Tyr Gly Pro His Thr Met Ser Gly Asp Asp Pro Thr 
            260                 265                 270         

Arg Tyr Arg Thr Lys Asp Val Gln Glu Glu Trp Glu Lys Lys Asp Pro 
        275                 280                 285             

Leu Ile Arg Phe Arg Lys Tyr Leu Glu Glu Lys Gly Leu Trp Ser Gln 
    290                 295                 300                 

Glu Glu Glu Glu Ala Tyr Ile Glu Glu Ala Lys Glu Thr Val Asn Asn 
305                 310                 315                 320 

Ala Leu Lys Glu Ala Asp Ala Ala Glu Lys Met Thr Ile Pro Gly Leu 
                325                 330                 335     

Ile Asp Ser Met Phe Glu Glu Leu Thr Pro Thr Leu Lys Arg Gln Arg 
            340                 345                 350         

Ala Glu Phe Ala Gly Glu Glu Ala Asn 
        355                 360     

<210>   1252
<211>   361
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1242

<400>   1252
Met Thr Met Leu Ser Gln Val Val Ala Arg Phe Glu Ile Pro Tyr Val 
                5                   10                  15      

Gln Ile Val Asp Glu Asn Gly Asn Val Val Asn Pro Asp Leu Val Pro 
            20                  25                  30          

Glu Leu Ser Asp Asp Asp Leu Arg Glu Leu Met Lys Arg Met Val Phe 
        35                  40                  45              

Thr Arg Ile Trp Asp Gln Arg Ala Ile Arg Leu Ser Arg Gln Gly Arg 
    50                  55                  60                  

Leu Gly Phe Tyr Ala Pro Val Ser Gly Gln Glu Ala Ser Met Ile Gly 
65                  70                  75                  80  

Ser Glu Phe Ala Thr Lys Lys Glu Asp Phe Leu Leu Pro Gly Tyr Arg 
                85                  90                  95      

Asp Ile Pro Gln Leu Tyr Phe His Gly Tyr Pro Leu His Gln Leu Phe 
            100                 105                 110         

Leu Tyr Ser Arg Gly His Gln Leu Gly Gly Lys Val Pro Glu Gly Val 
        115                 120                 125             

Asn Cys Met Val Pro Gln Ile Ile Ile Gly Ala Gln Ile Val Gln Ala 
    130                 135                 140                 

Ala Gly Val Gly Leu Ala Phe Lys Ile Arg Gly Glu Lys Arg Val Ala 
145                 150                 155                 160 

Val Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln Gly Asp Phe Tyr Glu 
                165                 170                 175     

Gly Met Asn Phe Ala Gly Ala Met Asn Leu Pro Val Val Phe Phe Val 
            180                 185                 190         

Gln Asn Asn Gln Tyr Ala Ile Ser Val Pro Arg Glu Leu Gln Thr Arg 
        195                 200                 205             

Ala Gln Thr Leu Ala Gln Lys Ala Ile Ala Ala Gly Ile Pro Gly Val 
    210                 215                 220                 

Gln Val Asp Gly Met Asp Val Leu Ala Val Tyr His Val Met His Glu 
225                 230                 235                 240 

Ala Leu Glu Arg Ala Arg Asn Gly Glu Gly Pro Thr Met Ile Glu Ala 
                245                 250                 255     

Val Thr Phe Arg Tyr Gly Pro His Thr Met Ser Gly Asp Asp Pro Thr 
            260                 265                 270         

Arg Tyr Arg Thr Lys Asp Val Gln Glu Glu Trp Glu Lys Lys Asp Pro 
        275                 280                 285             

Leu Ile Arg Phe Arg Lys Tyr Leu Glu Glu Lys Gly Leu Trp Ser Gln 
    290                 295                 300                 

Glu Glu Glu Glu Ala Tyr Ile Glu Glu Ala Lys Glu Thr Val Asn Asn 
305                 310                 315                 320 

Ala Leu Lys Glu Ala Asp Ala Ala Glu Lys Met Thr Ile Pro Gly Leu 
                325                 330                 335     

Ile Asp Ser Met Phe Glu Glu Leu Thr Pro Thr Leu Lys Arg Gln Arg 
            340                 345                 350         

Ala Glu Phe Ala Gly Glu Glu Ala Asn 
        355                 360     

<210>   1253
<211>   361
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1242

<400>   1253
Met Thr Met Leu Ser Gln Val Val Ala Arg Phe Glu Ile Pro Tyr Val 
                5                   10                  15      

Gln Ile Val Asp Glu Asn Gly Asn Val Val Asn Pro Asp Leu Val Pro 
            20                  25                  30          

Glu Leu Ser Asp Asp Asp Leu Arg Glu Leu Met Lys Arg Met Val Phe 
        35                  40                  45              

Thr Arg Ile Trp Asp Gln Arg Ala Ile Arg Leu Ser Arg Gln Gly Arg 
    50                  55                  60                  

Leu Gly Phe Tyr Ala Pro Val Ser Gly Gln Glu Ala Ser Met Ile Gly 
65                  70                  75                  80  

Ser Glu Phe Ala Thr Lys Lys Glu Asp Phe Leu Leu Pro Gly Tyr Arg 
                85                  90                  95      

Asp Ile Pro Gln Leu Tyr Phe His Gly Tyr Pro Leu His Gln Leu Phe 
            100                 105                 110         

Leu Tyr Ser Arg Gly His Gln Leu Gly Gly Lys Val Pro Glu Gly Val 
        115                 120                 125             

Asn Cys Met Val Pro Gln Ile Ile Ile Gly Ala Gln Ile Val Gln Ala 
    130                 135                 140                 

Ala Gly Val Gly Leu Ala Phe Lys Leu Arg Gly Glu Lys Arg Val Ala 
145                 150                 155                 160 

Val Thr Tyr Thr Gly Asp Gly Gly Thr Ser Gln Gly Asp Phe Tyr Glu 
                165                 170                 175     

Gly Met Asn Phe Ala Gly Ala Met Asn Leu Pro Val Val Phe Phe Val 
            180                 185                 190         

Gln Asn Asn Gln Tyr Ala Ile Ser Val Pro Arg Glu Leu Gln Thr Arg 
        195                 200                 205             

Ala Gln Thr Leu Ala Gln Lys Ala Ile Ala Ala Gly Ile Pro Gly Val 
    210                 215                 220                 

Gln Val Asp Gly Met Asp Val Leu Ala Val Tyr His Val Met His Glu 
225                 230                 235                 240 

Ala Leu Glu Arg Ala Arg Gln Gly Glu Gly Pro Thr Met Ile Glu Ala 
                245                 250                 255     

Val Thr Phe Arg Tyr Gly Pro His Thr Met Ser Gly Asp Asp Pro Thr 
            260                 265                 270         

Arg Tyr Arg Thr Lys Asp Val Gln Glu Glu Trp Glu Lys Lys Asp Pro 
        275                 280                 285             

Leu Ile Arg Phe Arg Lys Tyr Leu Glu Glu Lys Gly Leu Trp Ser Gln 
    290                 295                 300                 

Glu Glu Glu Glu Ala Tyr Ile Glu Glu Ala Lys Glu Thr Val Asn Asn 
305                 310                 315                 320 

Ala Leu Lys Glu Ala Asp Ala Ala Glu Lys Met Thr Ile Pro Gly Leu 
                325                 330                 335     

Ile Asp Ser Met Phe Glu Glu Leu Thr Pro Thr Leu Lys Arg Gln Arg 
            340                 345                 350         

Ala Glu Phe Ala Gly Glu Glu Ala Asn 
        355                 360     

<210>   1254
<211>   1086
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1243

<400>   1254
gtgaccatgt tgagccaggt ggttgctcgt tttgagatcc cgtacgtcca aatcgtggac       60

gagaacggga acgtcgtgaa ccctgacctg gtcccggagt tgtcggacga cgacctgcgc      120

gagctcatga agcgcatggt cttcacgcgc atctgggatc aacgcgcaat tcgcctgtcc      180

cggcagggac gcctgggctt ttacgcgccg gtgtccggcc aggaagcgtc catgatcggc      240

agcgagttcg ccacgaagaa agaggacttc ctgctcccgg gctatcgcga catcccgcag      300

ctgtacttcc acgggtatcc gctgcatcag ctcttccttt actcccgcgg acatcagctt      360

ggcggcaaag ttcctgaagg cgtcaactgt atggtgccgc agatcatcat cggagcgcaa      420

atcgtccagg cggcgggcgt cggcctcgcg ttcaagctgc gcggtgaaaa gcgcgtggcg      480

gtcacgtaca cgggcgacgg cggcacgagc cagggcgact tttacgaagg catgaacttc      540

gcgggcgcca tgaatctccc cgtggtgttc tttgttcaga acaaccagta cgccatttct      600

gtgcctcgcg agcttcagac tcgtgcgcag acgctcgctc agaaggccat cgcggccggc      660

atccccggcg tgcaagtcga cggcatggac gtgttggccg tgtaccacgt gatgcacgaa      720

gcccttgagc gcgcgcgcaa cggcgagggc ccaaccatga ttgaggccgt gaccttccgc      780

tacggccccc acacgatgtc gggcgacgat ccgacccgtt atcgcacgaa ggacgtgcag      840

gaagagtggg agaagaagga tccgctcatc cgcttccgca agtacctcga ggaaaaggga      900

ctttggtctc aagaagagga agaggcttac atcgaggagg ccaaggagac ggtcaacaac      960

gccctcaagg aggcggatgc ggcggagaag atgaccatcc cgggtctcat cgaatcgatg     1020

ttcgaagaac tcaccccgac gctcaagcgc cagcgggcgg aatttgccgg cgaggaggcg     1080

aactga                                                                1086


<210>   1255
<211>   1086
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1243

<400>   1255
gtgaccatgt tgagccaggt ggttgctcgt tttgagatcc cgtacgtcca aatcgtggac       60

gagaacggga acgtcgtgaa ccctgacctg gtcccggagt tgtcggacga cgacctgcgc      120

gagctcatga agcgcatggt cttcacgcgc atctgggatc aacgcgcaat tcgcctgtcc      180

cggcagggac gcctgggctt ttacgcgccg gtgtccggcc aggaagcgtc catgatcggc      240

agcgagttcg ccacgaagaa agaggacttc ctgctcccgg gctatcgcga catcccgcag      300

ctgtacttcc acgggtatcc gctgcatcag ctcttccttt actcccgcgg acatcagctt      360

ggcggcaaag ttcctgaagg cgtcaactgt atggtgccgc agatcatcat cggagcgcaa      420

atcgtccagg cggcgggcgt cggcctcgcg ttcaagctgc gcggtgaaaa gcgcgtggcg      480

gtcacgtaca cgggcgacgg cggcacgagc cagggcgact tttacgaagg catgaacttc      540

gcgggcgcca tgaatctccc cgtggtgttc tttgttcaga acaaccagta cgccatttct      600

gtgcctcgcg agcttcagac tcgtgcgcag acgctcgctc agaaggccat cgcggccggc      660

atccccggcg tgcaagtcga cggcatggac gtgttggccg tgtaccacgt gatgcacgaa      720

gcccttgagc gcgcgcgcaa cggcgagggc ccaaccatga ttgaggccgt gaccttccgc      780

tacggccccc acacgatgtc gggcgacgat ccgacccgtt atcgcacgaa ggacgtgcag      840

gaagagtggg agaagaagga tccgctcatc cgcttccgca agtacctcga ggataaggga      900

ctttggtctc aagaagagga agaggcttac atcgaggagg ccaaggagac ggtcaacaac      960

gccctcaagg aggcggatgc ggcggagaag atgaccatcc cgggtctcat cgactcgatg     1020

ttcgaagaac tcaccccgac gctcaagcgc cagcgggcgg aatttgccgg cgaggaggcg     1080

aactga                                                                1086


<210>   1256
<211>   1086
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1243

<400>   1256
gtgaccatgt tgagccaggt ggttgctcgt tttgagatcc cgtacgtcca aatcgtggac       60

gagaacggga acgtcgtgaa ccctgacctg gtcccggagt tgtcggacga cgacctgcgc      120

gagctcatga agcgcatggt cttcacgcgc atctgggatc aacgcgcaat tcgcctgtcc      180

cggcagggac gcctgggctt ttacgcgccg gtgtccggcc aggaagcgtc catgatcggc      240

agcgagttcg ccacgaagaa agaggacttc ctgctcccgg gctatcgcga catcccgcag      300

ctgtacttcc acgggtatcc gctgcatcag ctcttccttt actcccgcgg acatcagctt      360

ggcggcaaag ttcctgaagg cgtcaactgt atggtgccgc agatcatcat cggagcgcaa      420

atcgtccagg cggcgggcgt cggcctcgcg ttcaagctgc gcggtgaaaa gcgcgtggcg      480

gtcacgtaca cgggcgacgg cggcacgagc cagggcgact tttacgaagg catgaacttc      540

gcgggcgcca tgaatctccc cgtggtgttc tttgttcaga acaaccagta cgccatttct      600

gtgcctcgcg agcttcagac tcgtgcgcag acgctcgctc agaaggccat cgcggccggc      660

atccccggcg tgcaagtcga cggcatggac gtgttggccg tgtaccacgt gatgcacgaa      720

gcccttgagc gcgcgaaaaa cggcgagggc ccaaccatga ttgaggccgt gaccttccgc      780

tacggccccc acacgatgtc gggcgacgat ccgacccgtt atcgcacgaa ggacgtgcag      840

gaagagtggg agaagaagga tccgctcatc cgcttccgca agtacctcga ggaaaaggga      900

ctttggtctc aagaagagga agaggcttac atcgaggagg ccaaggagac ggtcaacaac      960

gccctcaagg aggcggatgc ggcggagaag atgaccatcc cgggtctcat cgactcgatg     1020

ttcgaagaac tcaccccgac gctcaagcgc cagcgggcgg aatttgccgg cgaggaggcg     1080

aactga                                                                1086


<210>   1257
<211>   1086
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1243

<400>   1257
gtgaccatgt tgagccaggt ggttgctcgt tttgagatcc cgtacgtcca aatcgtggac       60

gagaacggga acgtcgtgaa ccctgacctg gtcccggagt tgtcggacga cgacctgcgc      120

gagctcatga agcgcatggt cttcacgcgc atctgggatc aacgcgcaat tcgcctgtcc      180

cggcagggac gcctgggctt ttacgcgccg gtgtccggcc aggaagcgtc catgatcggc      240

agcgagttcg ccacgaagaa agaggacttc ctgctcccgg gctatcgcga catcccgcag      300

ctgtacttcc acgggtatcc gctgcatcag ctcttccttt actcccgcgg acatcagctt      360

ggcggcaaag ttcctgaagg cgtcaactgt atggtgccgc agatcatcat cggagcgcaa      420

atcgtccagg cggcgggcgt cggcctcgcg ttcaagattc gcggtgaaaa gcgcgtggcg      480

gtcacgtaca cgggcgacgg cggcacgagc cagggcgact tttacgaagg catgaacttc      540

gcgggcgcca tgaatctccc cgtggtgttc tttgttcaga acaaccagta cgccatttct      600

gtgcctcgcg agcttcagac tcgtgcgcag acgctcgctc agaaggccat cgcggccggc      660

atccccggcg tgcaagtcga cggcatggac gtgttggccg tgtaccacgt gatgcacgaa      720

gcccttgagc gcgcgcgcaa cggcgagggc ccaaccatga ttgaggccgt gaccttccgc      780

tacggccccc acacgatgtc gggcgacgat ccgacccgtt atcgcacgaa ggacgtgcag      840

gaagagtggg agaagaagga tccgctcatc cgcttccgca agtacctcga ggaaaaggga      900

ctttggtctc aagaagagga agaggcttac atcgaggagg ccaaggagac ggtcaacaac      960

gccctcaagg aggcggatgc ggcggagaag atgaccatcc cgggtctcat cgactcgatg     1020

ttcgaagaac tcaccccgac gctcaagcgc cagcgggcgg aatttgccgg cgaggaggcg     1080

aactga                                                                1086


<210>   1258
<211>   1086
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1243

<400>   1258
gtgaccatgt tgagccaggt ggttgctcgt tttgagatcc cgtacgtcca aatcgtggac       60

gagaacggga acgtcgtgaa ccctgacctg gtcccggagt tgtcggacga cgacctgcgc      120

gagctcatga agcgcatggt cttcacgcgc atctgggatc aacgcgcaat tcgcctgtcc      180

cggcagggac gcctgggctt ttacgcgccg gtgtccggcc aggaagcgtc catgatcggc      240

agcgagttcg ccacgaagaa agaggacttc ctgctcccgg gctatcgcga catcccgcag      300

ctgtacttcc acgggtatcc gctgcatcag ctcttccttt actcccgcgg acatcagctt      360

ggcggcaaag ttcctgaagg cgtcaactgt atggtgccgc agatcatcat cggagcgcaa      420

atcgtccagg cggcgggcgt cggcctcgcg ttcaagctgc gcggtgaaaa gcgcgtggcg      480

gtcacgtaca cgggcgacgg cggcacgagc cagggcgact tttacgaagg catgaacttc      540

gcgggcgcca tgaatctccc cgtggtgttc tttgttcaga acaaccagta cgccatttct      600

gtgcctcgcg agcttcagac tcgtgcgcag acgctcgctc agaaggccat cgcggccggc      660

atccccggcg tgcaagtcga cggcatggac gtgttggccg tgtaccacgt gatgcacgaa      720

gcccttgagc gcgcgcgcca aggcgagggc ccaaccatga ttgaggccgt gaccttccgc      780

tacggccccc acacgatgtc gggcgacgat ccgacccgtt atcgcacgaa ggacgtgcag      840

gaagagtggg agaagaagga tccgctcatc cgcttccgca agtacctcga ggaaaaggga      900

ctttggtctc aagaagagga agaggcttac atcgaggagg ccaaggagac ggtcaacaac      960

gccctcaagg aggcggatgc ggcggagaag atgaccatcc cgggtctcat cgactcgatg     1020

ttcgaagaac tcaccccgac gctcaagcgc cagcgggcgg aatttgccgg cgaggaggcg     1080

aactga                                                                1086


<210>   1259
<211>   334
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1259
Met Pro Ala Arg Arg Arg Thr Asp Met Ala Gln Met Thr Met Ile Gln 
                5                   10                  15      

Ala Ile Thr His Ala Leu Asp Leu Glu Leu Ala Arg Asp Glu Arg Val 
            20                  25                  30          

Leu Val Phe Gly Glu Asp Val Gly Lys Asn Gly Gly Val Phe Arg Ala 
        35                  40                  45              

Thr Glu Gly Leu Gln Gln Lys Tyr Gly Pro Asn Arg Val Phe Asp Thr 
    50                  55                  60                  

Pro Leu Ala Glu Ser Gly Ile Ile Gly Leu Ala Asn Gly Leu Ala Ile 
65                  70                  75                  80  

Gln Gly Phe Arg Pro Val Pro Glu Ile Gln Phe Phe Gly Phe Val Phe 
                85                  90                  95      

Glu Ala Phe Asp Gln Ile Ala Gly Gln Leu Ala Arg Thr Arg Tyr Arg 
            100                 105                 110         

Thr Gly Gly Arg Tyr Thr Ala Pro Val Thr Ile Arg Ser Pro Phe Gly 
        115                 120                 125             

Gly Gly Val His Thr Pro Glu Met His Ala Asp Ser Leu Glu Gly Leu 
    130                 135                 140                 

Phe Val Gln Thr Pro Gly Ile Lys Val Val Ile Pro Ser Thr Pro Tyr 
145                 150                 155                 160 

Asp Ala Lys Gly Leu Leu Leu Ser Ala Ile Arg Asp Pro Asp Pro Val 
                165                 170                 175     

Ile Phe Leu Glu His Met Lys Leu Tyr Arg Ser Phe Arg Gln Glu Val 
            180                 185                 190         

Pro Glu Asp Asp Tyr Thr Ile Pro Leu Gly Val Ala Asn Val Val Arg 
        195                 200                 205             

Glu Gly Lys His Ala Thr Val Ile Ala Tyr Gly Ala Met Val His Val 
    210                 215                 220                 

Ala Leu Lys Ala Ala Glu Gln Trp Ser Lys Glu Lys Gly Leu Glu Ala 
225                 230                 235                 240 

Glu Val Ile Asp Leu Arg Thr Val Asn Pro Ile Asp Ile Asp Thr Ile 
                245                 250                 255     

Val Ala Ser Val Lys Lys Thr Asn Arg Ala Ile Val Val Gln Glu Ala 
            260                 265                 270         

Gln Arg Ser Ala Gly Ala Ala Ala Glu Ile Val Ala Gln Ile Asn Glu 
        275                 280                 285             

Asn Ala Ile Tyr Tyr Leu Glu Ala Pro Val Leu Arg Ala Thr Pro Pro 
    290                 295                 300                 

Asp Thr Val Tyr Pro Phe Gly Met Ile Glu Asp Glu Trp Leu Pro Thr 
305                 310                 315                 320 

Pro Glu Tyr Val Leu Lys Thr Leu Asp Lys Val Met Ser Leu 
                325                 330                 

<210>   1260
<211>   1005
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1260
ttgccggcga ggaggcgaac tgacatggcg cagatgacga tgattcaggc gatcacgcac       60

gccctcgatc tcgaactggc gcgcgacgag cgcgtgctcg tcttcggcga ggacgtcggc      120

aaaaacggcg gcgtcttccg cgcgaccgaa ggcctgcagc agaaatacgg gcccaaccgc      180

gtgttcgaca cgccgctcgc ggagagtggc atcatcggac tggccaacgg ccttgcgatt      240

caagggtttc gccccgtacc cgaaattcag ttttttgggt ttgtcttcga ggcgttcgac      300

cagatcgcgg gtcagctggc gcgcacgagg tatcgcaccg gcggccgcta caccgcgcct      360

gtgaccatcc gttctccgtt cggcggcggg gtgcacacgc ccgaaatgca cgcggattcc      420

ctggaaggcc tgtttgttca aacaccgggc atcaaggtgg tgattccgag cacgccctac      480

gacgccaagg gactgctgct gtcggccatt cgggacccgg atccagtcat cttcctggaa      540

cacatgaaac tgtatcgctc gttccgccag gaagtgccgg aggacgatta caccatcccg      600

ctcggcgtcg cgaacgtggt ccgagagggc aagcatgcca ccgtcatcgc ctatggggcc      660

atggtgcacg tggcgctgaa ggccgcggaa cagtggtcga aagaaaaggg cctcgaggcc      720

gaggtcatcg atcttcgcac cgtcaacccg attgacatcg ataccatcgt ggcgtcggtc      780

aagaagacga accgcgccat cgtcgtgcag gaagctcagc gttcggcggg cgccgcggcc      840

gagatcgtcg cgcaaatcaa cgaaaacgcg atttactact tggaagcacc ggttctccgc      900

gcaacgccgc ccgacacggt gtatccgttt ggtatgattg aggacgaatg gttgccgaca      960

cccgagtatg tcctcaagac gctcgataaa gtcatgagct tataa                     1005


<210>   1261
<211>   324
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   1261
Met Ala Gln Leu Thr Met Ile Gln Ala Ile Thr Asp Ala Leu Arg Thr 
                5                   10                  15      

Glu Leu Lys Asn Asp Glu Asn Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Val Asn Gly Gly Val Phe Arg Ala Thr Glu Gly Leu Gln Lys Glu Phe 
        35                  40                  45              

Gly Lys Asp Arg Val Ile Asp Thr Pro Leu Ala Glu Ser Gly Ile Asn 
    50                  55                  60                  

Gly Leu Ala Ile Gly Leu Ala Leu Gln Gly Phe Arg Pro Val Pro Glu 
65                  70                  75                  80  

Ile Gln Phe Phe Gly Phe Val Phe Glu Thr Met Asp Ser Ile His Gly 
                85                  90                  95      

Gln Met Ala Arg Tyr Arg Phe Arg Thr Gly Gly Asp Leu Lys Met Pro 
            100                 105                 110         

Ile Thr Ile Arg Ala Pro Phe Gly Gly Gly Val His Thr Pro Glu Met 
        115                 120                 125             

His Ala Asp Ser Leu Glu Gly Leu Met Ala Gln Thr Pro Gly Ile Lys 
    130                 135                 140                 

Val Val Ile Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Arg Asp Asn Asp Pro Val Val Phe Leu Glu His Met Lys Leu 
                165                 170                 175     

Tyr Arg Ser Phe Arg Glu Glu Val Pro Glu Glu Glu Tyr Thr Ile Pro 
            180                 185                 190         

Leu Gly Lys Ala Asp Val Lys Arg Glu Gly Lys Asp Ile Ser Ile Ile 
        195                 200                 205             

Ala Tyr Gly Ala Met Val His Glu Ser Leu Lys Ala Ala Asp Glu Leu 
    210                 215                 220                 

Glu Lys Glu Gly Tyr Ser Ala Glu Val Val Asp Leu Arg Thr Val Ser 
225                 230                 235                 240 

Pro Leu Asp Val Glu Thr Ile Val Ala Ser Val Glu Lys Thr Asn Arg 
                245                 250                 255     

Ala Ile Val Val Gln Glu Ala Gln Arg Gln Ala Gly Val Ala Ala Asn 
            260                 265                 270         

Val Val Ala Glu Ile Asn Glu Arg Ala Ile Leu Ser Leu Glu Ala Pro 
        275                 280                 285             

Val Leu Arg Val Thr Ala Pro Asp Thr Val Tyr Pro Phe Ser Gln Ala 
    290                 295                 300                 

Glu Gly Val Trp Ile Pro Thr Tyr Lys Asp Ile Leu Glu Lys Ala Lys 
305                 310                 315                 320 

Glu Thr Leu Thr 
                

<210>   1262
<211>   324
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   1262
Met Ala Gln Met Thr Met Val Gln Ala Ile Thr Asp Ala Leu Arg Ile 
                5                   10                  15      

Glu Leu Lys Asn Asp Pro Asn Val Leu Ile Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Val Asn Gly Gly Val Phe Arg Ala Thr Glu Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Asp Arg Val Phe Asp Thr Pro Leu Ala Glu Ser Gly Ile Gly 
    50                  55                  60                  

Gly Leu Ala Ile Gly Leu Ala Leu Gln Gly Phe Arg Pro Val Pro Glu 
65                  70                  75                  80  

Ile Gln Phe Phe Gly Phe Val Tyr Glu Val Met Asp Ser Ile Cys Gly 
                85                  90                  95      

Gln Met Ala Arg Ile Arg Tyr Arg Thr Gly Gly Arg Tyr His Met Pro 
            100                 105                 110         

Ile Thr Ile Arg Ser Pro Phe Gly Gly Gly Val His Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Gly Leu Val Ala Gln Gln Pro Gly Leu Lys 
    130                 135                 140                 

Val Val Ile Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Arg Asp Asn Asp Pro Val Ile Phe Leu Glu His Leu Lys Leu 
                165                 170                 175     

Tyr Arg Ser Phe Arg Gln Glu Val Pro Glu Gly Glu Tyr Thr Ile Pro 
            180                 185                 190         

Ile Gly Lys Ala Asp Ile Lys Arg Glu Gly Lys Asp Ile Thr Ile Ile 
        195                 200                 205             

Ala Tyr Gly Ala Met Val His Glu Ser Leu Lys Ala Ala Ala Glu Leu 
    210                 215                 220                 

Glu Lys Glu Gly Ile Ser Ala Glu Val Val Asp Leu Arg Thr Val Gln 
225                 230                 235                 240 

Pro Leu Asp Ile Glu Thr Ile Ile Gly Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Ile Val Val Gln Glu Ala Gln Arg Gln Ala Gly Ile Ala Ala Asn 
            260                 265                 270         

Val Val Ala Glu Ile Asn Glu Arg Ala Ile Leu Ser Leu Glu Ala Pro 
        275                 280                 285             

Val Leu Arg Val Ala Ala Pro Asp Thr Val Tyr Pro Phe Ala Gln Ala 
    290                 295                 300                 

Glu Ser Val Trp Leu Pro Asn Phe Lys Asp Val Ile Glu Thr Ala Lys 
305                 310                 315                 320 

Lys Val Met Asn 
                

<210>   1263
<211>   324
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1263
Met Ala Gln Met Thr Met Val Gln Ala Ile Thr Asp Ala Leu Arg Ile 
                5                   10                  15      

Glu Leu Lys Asn Asp Pro Asn Val Leu Ile Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Val Asn Gly Gly Val Phe Arg Ala Thr Glu Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Glu Arg Val Phe Asp Thr Pro Leu Ala Glu Ser Gly Ile Gly 
    50                  55                  60                  

Gly Leu Ala Val Gly Leu Ala Leu Gln Gly Phe Arg Pro Val Pro Glu 
65                  70                  75                  80  

Ile Gln Phe Phe Gly Phe Val Tyr Glu Val Met Asp Ser Ile Ser Gly 
                85                  90                  95      

Gln Met Ala Arg Ile Arg Tyr Arg Thr Gly Gly Arg Tyr His Met Pro 
            100                 105                 110         

Ile Thr Val Arg Ser Pro Phe Gly Gly Gly Val His Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Gly Leu Val Ala Gln Gln Pro Gly Leu Lys 
    130                 135                 140                 

Val Val Ile Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Arg Asp Asn Asp Pro Val Ile Phe Leu Glu His Leu Lys Leu 
                165                 170                 175     

Tyr Arg Ser Phe Arg Gln Glu Val Pro Glu Gly Glu Tyr Thr Ile Pro 
            180                 185                 190         

Ile Gly Lys Ala Asp Ile Lys Arg Glu Gly Lys Asp Ile Thr Ile Ile 
        195                 200                 205             

Ala Tyr Gly Ala Met Val His Glu Ser Leu Lys Ala Ala Ala Glu Leu 
    210                 215                 220                 

Glu Lys Glu Gly Ile Ser Ala Glu Val Val Asp Leu Arg Thr Val Gln 
225                 230                 235                 240 

Pro Leu Asp Ile Glu Thr Ile Ile Gly Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Ile Val Val Gln Glu Ala Gln Arg Gln Ala Gly Ile Ala Ala Asn 
            260                 265                 270         

Val Val Ala Glu Ile Asn Glu Arg Ala Ile Leu Ser Leu Glu Ala Pro 
        275                 280                 285             

Val Leu Arg Val Ala Ala Pro Asp Thr Val Tyr Pro Phe Ala Gln Ala 
    290                 295                 300                 

Glu Ser Val Trp Leu Pro Asn Phe Lys Asp Val Ile Glu Thr Ala Lys 
305                 310                 315                 320 

Lys Val Met Asn 
                

<210>   1264
<211>   323
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   1264
Ala Gln Met Thr Met Val Gln Ala Ile Thr Asp Ala Leu Arg Ile Glu 
                5                   10                  15      

Leu Lys Asn Asp Pro Asn Val Leu Ile Phe Gly Glu Asp Val Gly Val 
            20                  25                  30          

Asn Gly Gly Val Phe Arg Ala Thr Glu Gly Leu Gln Ala Glu Phe Gly 
        35                  40                  45              

Glu Asp Arg Val Phe Asp Thr Pro Leu Ala Glu Ser Gly Ile Gly Gly 
    50                  55                  60                  

Leu Ala Ile Gly Leu Ala Leu Gln Gly Phe Arg Pro Val Pro Glu Ile 
65                  70                  75                  80  

Gln Phe Phe Gly Phe Val Tyr Glu Val Met Asp Ser Ile Cys Gly Gln 
                85                  90                  95      

Met Ala Arg Ile Arg Tyr Arg Thr Gly Gly Arg Tyr His Met Pro Ile 
            100                 105                 110         

Thr Ile Arg Ser Pro Phe Gly Gly Gly Val His Thr Pro Glu Leu His 
        115                 120                 125             

Ser Asp Ser Leu Glu Gly Leu Val Ala Gln Gln Pro Gly Leu Lys Val 
    130                 135                 140                 

Val Ile Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser Ala 
145                 150                 155                 160 

Ile Arg Asp Asn Asp Pro Val Ile Phe Leu Glu His Leu Lys Leu Tyr 
                165                 170                 175     

Arg Ser Phe Arg Gln Glu Val Pro Glu Gly Glu Tyr Thr Ile Pro Ile 
            180                 185                 190         

Gly Lys Ala Asp Ile Lys Arg Glu Gly Lys Asp Ile Thr Ile Ile Ala 
        195                 200                 205             

Tyr Gly Ala Met Val His Glu Ser Leu Lys Ala Ala Ala Glu Leu Glu 
    210                 215                 220                 

Lys Glu Gly Ile Ser Ala Glu Val Val Asp Leu Arg Thr Val Gln Pro 
225                 230                 235                 240 

Leu Asp Ile Glu Thr Ile Ile Gly Ser Val Glu Lys Thr Gly Arg Ala 
                245                 250                 255     

Ile Val Val Gln Glu Ala Gln Arg Gln Ala Gly Ile Ala Ala Asn Val 
            260                 265                 270         

Val Ala Glu Ile Asn Glu Arg Ala Ile Leu Ser Leu Glu Ala Pro Val 
        275                 280                 285             

Leu Arg Val Ala Ala Pro Asp Thr Val Tyr Pro Phe Ala Gln Ala Glu 
    290                 295                 300                 

Ser Val Trp Leu Pro Asn Phe Lys Asp Val Ile Glu Thr Ala Lys Lys 
305                 310                 315                 320 

Val Met Asn 
            

<210>   1265
<211>   324
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1265
Met Ala Gln Met Thr Met Val Gln Ala Ile Thr Asp Ala Leu Arg Ile 
                5                   10                  15      

Glu Met Arg Asn Asp Pro Asn Val Leu Val Phe Gly Glu Asp Val Gly 
            20                  25                  30          

Val Asn Gly Gly Val Phe Arg Val Thr Glu Gly Leu Gln Ala Glu Phe 
        35                  40                  45              

Gly Glu Glu Arg Val Phe Asp Thr Pro Leu Ala Glu Ser Gly Ile Gly 
    50                  55                  60                  

Gly Leu Ala Ile Gly Leu Ala Leu Gln Gly Phe Arg Pro Val Pro Glu 
65                  70                  75                  80  

Ile Gln Phe Phe Gly Phe Val Tyr Glu Ala Met Asp Ala Ile Cys Gly 
                85                  90                  95      

Gln Met Ala Arg Ile Arg Tyr Arg Thr Gly Gly Arg Tyr His Val Pro 
            100                 105                 110         

Ile Thr Ile Arg Ser Pro Phe Gly Gly Gly Val His Thr Pro Glu Leu 
        115                 120                 125             

His Ser Asp Ser Leu Glu Gly Leu Val Ala Gln Gln Pro Gly Leu Lys 
    130                 135                 140                 

Val Val Ile Pro Ser Thr Pro Tyr Asp Ala Lys Gly Leu Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Arg Asp Asn Asp Pro Val Ile Phe Leu Glu His Leu Lys Leu 
                165                 170                 175     

Tyr Arg Ser Phe Arg Gln Glu Val Pro Glu Gly Glu Tyr Thr Ile Pro 
            180                 185                 190         

Ile Gly Lys Ala Asp Ile Lys Arg Glu Gly Lys Asp Ile Thr Ile Ile 
        195                 200                 205             

Ala Tyr Gly Ala Met Val His Glu Ser Leu Lys Ala Ala Ala Glu Leu 
    210                 215                 220                 

Glu Lys Glu Gly Ile Ser Ala Glu Val Val Asp Leu Arg Thr Val Gln 
225                 230                 235                 240 

Pro Leu Asp Ile Glu Thr Ile Ile Gly Ser Val Glu Lys Thr Gly Arg 
                245                 250                 255     

Ala Ile Val Val Gln Glu Ala Gln Arg Gln Ala Gly Ile Ala Ala Asn 
            260                 265                 270         

Val Val Ala Glu Ile Asn Glu Arg Ala Ile Leu Ser Leu Glu Ala Pro 
        275                 280                 285             

Val Leu Arg Val Ala Ala Pro Asp Thr Val Tyr Pro Phe Ala Gln Ala 
    290                 295                 300                 

Glu Ser Val Trp Leu Pro Asn Phe Lys Asp Val Ile Glu Thr Ala Lys 
305                 310                 315                 320 

Lys Val Ile Asn 
                

<210>   1266
<211>   334
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1259

<400>   1266
Met Pro Ala Arg Lys Arg Thr Asp Met Ala Gln Met Thr Met Ile Gln 
                5                   10                  15      

Ala Ile Thr His Ala Leu Asp Leu Glu Leu Ala Arg Asp Glu Arg Val 
            20                  25                  30          

Leu Val Phe Gly Glu Asp Val Gly Lys Asn Gly Gly Val Phe Arg Ala 
        35                  40                  45              

Thr Glu Gly Leu Gln Gln Lys Tyr Gly Pro Asn Arg Val Phe Asp Thr 
    50                  55                  60                  

Pro Leu Ala Glu Ser Gly Ile Ile Gly Leu Ala Asn Gly Leu Ala Ile 
65                  70                  75                  80  

Gln Gly Phe Arg Pro Val Pro Glu Ile Gln Phe Phe Gly Phe Val Phe 
                85                  90                  95      

Glu Ala Phe Asp Gln Ile Ala Gly Gln Leu Ala Arg Thr Arg Tyr Arg 
            100                 105                 110         

Thr Gly Gly Arg Tyr Thr Ala Pro Val Thr Ile Arg Ser Pro Phe Gly 
        115                 120                 125             

Gly Gly Val His Thr Pro Glu Met His Ala Asp Ser Leu Glu Gly Leu 
    130                 135                 140                 

Phe Val Gln Thr Pro Gly Ile Lys Val Val Ile Pro Ser Thr Pro Tyr 
145                 150                 155                 160 

Asp Ala Lys Gly Leu Leu Leu Ser Ala Ile Arg Asp Pro Asp Pro Val 
                165                 170                 175     

Ile Phe Leu Glu His Met Lys Leu Tyr Arg Ser Phe Arg Gln Glu Val 
            180                 185                 190         

Pro Glu Asp Asp Tyr Thr Ile Pro Leu Gly Val Ala Asn Val Val Arg 
        195                 200                 205             

Glu Gly Lys His Ala Thr Val Ile Ala Tyr Gly Ala Met Val His Val 
    210                 215                 220                 

Ala Leu Lys Ala Ala Glu Gln Trp Ser Lys Glu Lys Gly Leu Glu Ala 
225                 230                 235                 240 

Glu Val Ile Asp Leu Arg Thr Val Asn Pro Ile Asp Ile Asp Thr Ile 
                245                 250                 255     

Val Ala Ser Val Lys Lys Thr Asn Arg Ala Ile Val Val Gln Glu Ala 
            260                 265                 270         

Gln Arg Ser Ala Gly Ala Ala Ala Glu Ile Val Ala Gln Ile Asn Glu 
        275                 280                 285             

Asn Ala Ile Tyr Tyr Leu Glu Ala Pro Val Leu Arg Ala Thr Pro Pro 
    290                 295                 300                 

Asp Thr Val Tyr Pro Phe Gly Met Ile Glu Asp Glu Trp Leu Pro Thr 
305                 310                 315                 320 

Pro Glu Tyr Val Leu Lys Thr Leu Asp Lys Val Met Ser Leu 
                325                 330                 

<210>   1267
<211>   334
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1259

<400>   1267
Met Pro Ala Arg Arg Arg Thr Asp Met Ala Gln Met Thr Met Ile Gln 
                5                   10                  15      

Ala Ile Thr His Ala Leu Asp Ile Glu Leu Ala Arg Asp Glu Arg Val 
            20                  25                  30          

Leu Val Phe Gly Glu Asp Val Gly Lys Asn Gly Gly Val Phe Arg Ala 
        35                  40                  45              

Thr Glu Gly Leu Gln Gln Lys Tyr Gly Pro Asn Arg Val Phe Asp Thr 
    50                  55                  60                  

Pro Leu Ala Glu Ser Gly Ile Ile Gly Leu Ala Asn Gly Leu Ala Ile 
65                  70                  75                  80  

Gln Gly Phe Arg Pro Val Pro Glu Ile Gln Phe Phe Gly Phe Val Phe 
                85                  90                  95      

Glu Ala Phe Asp Gln Ile Ala Gly Gln Leu Ala Arg Thr Arg Tyr Arg 
            100                 105                 110         

Thr Gly Gly Arg Tyr Thr Ala Pro Val Thr Ile Arg Ser Pro Phe Gly 
        115                 120                 125             

Gly Gly Val His Thr Pro Glu Met His Ala Asp Ser Leu Glu Gly Leu 
    130                 135                 140                 

Phe Val Gln Thr Pro Gly Ile Lys Val Val Ile Pro Ser Thr Pro Tyr 
145                 150                 155                 160 

Asp Ala Lys Gly Leu Leu Leu Ser Ala Ile Arg Asp Pro Asp Pro Val 
                165                 170                 175     

Ile Phe Leu Glu His Met Lys Leu Tyr Arg Ser Phe Arg Gln Glu Val 
            180                 185                 190         

Pro Glu Asp Asp Tyr Thr Ile Pro Leu Gly Val Ala Asn Val Val Arg 
        195                 200                 205             

Glu Gly Lys His Ala Thr Val Ile Ala Tyr Gly Ala Met Val His Val 
    210                 215                 220                 

Ala Leu Lys Ala Ala Glu Gln Trp Ser Lys Glu Lys Gly Leu Glu Ala 
225                 230                 235                 240 

Glu Val Ile Asp Leu Arg Thr Val Asn Pro Ile Asp Ile Asp Thr Ile 
                245                 250                 255     

Val Ala Ser Val Lys Lys Thr Asn Arg Ala Ile Val Val Gln Glu Ala 
            260                 265                 270         

Gln Arg Ser Ala Gly Ala Ala Ala Glu Ile Val Ala Gln Ile Asn Glu 
        275                 280                 285             

Asn Ala Ile Tyr Tyr Leu Glu Ala Pro Val Leu Arg Ala Thr Pro Pro 
    290                 295                 300                 

Asp Thr Val Tyr Pro Phe Gly Met Ile Glu Asp Glu Trp Leu Pro Thr 
305                 310                 315                 320 

Pro Glu Tyr Val Leu Lys Thr Leu Asp Lys Val Met Ser Leu 
                325                 330                 

<210>   1268
<211>   334
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1259

<400>   1268
Met Pro Ala Arg Arg Arg Thr Asp Met Ala Gln Met Thr Met Ile Gln 
                5                   10                  15      

Ala Ile Thr His Ala Leu Asp Leu Glu Leu Ala Arg Asp Glu Arg Val 
            20                  25                  30          

Leu Val Phe Gly Glu Asp Val Gly Lys Asn Gly Gly Val Phe Arg Ala 
        35                  40                  45              

Thr Glu Gly Leu Gln Gln Lys Tyr Gly Pro Asn Arg Val Phe Asp Thr 
    50                  55                  60                  

Pro Leu Ala Glu Ser Gly Ile Ile Gly Leu Ala Asn Gly Leu Ala Ile 
65                  70                  75                  80  

Gln Gly Phe Arg Pro Val Pro Glu Ile Gln Phe Phe Gly Phe Val Phe 
                85                  90                  95      

Glu Ala Phe Asp Gln Ile Ala Gly Gln Leu Ala Arg Thr Arg Tyr Arg 
            100                 105                 110         

Thr Gly Gly Arg Tyr Thr Ala Pro Val Thr Ile Arg Ser Pro Phe Gly 
        115                 120                 125             

Gly Gly Val His Thr Pro Glu Met His Ala Asp Ser Leu Glu Gly Leu 
    130                 135                 140                 

Phe Val Gln Thr Pro Gly Ile Lys Val Val Ile Pro Ser Thr Pro Tyr 
145                 150                 155                 160 

Asp Ala Lys Gly Leu Leu Leu Ser Ala Ile Arg Asp Pro Asp Pro Val 
                165                 170                 175     

Ile Phe Leu Glu His Met Lys Leu Tyr Arg Ser Phe Arg Gln Glu Val 
            180                 185                 190         

Pro Glu Asp Asp Tyr Thr Ile Pro Leu Gly Val Ala Asn Val Val Arg 
        195                 200                 205             

Glu Gly Lys His Ala Thr Val Ile Ala Tyr Gly Ala Met Val His Ile 
    210                 215                 220                 

Ala Leu Lys Ala Ala Glu Gln Trp Ser Lys Glu Lys Gly Leu Glu Ala 
225                 230                 235                 240 

Glu Val Ile Asp Leu Arg Thr Val Asn Pro Ile Asp Ile Asp Thr Ile 
                245                 250                 255     

Val Ala Ser Val Lys Lys Thr Asn Arg Ala Ile Val Val Gln Glu Ala 
            260                 265                 270         

Gln Arg Ser Ala Gly Ala Ala Ala Glu Ile Val Ala Gln Ile Asn Glu 
        275                 280                 285             

Asn Ala Ile Tyr Tyr Leu Glu Ala Pro Val Leu Arg Ala Thr Pro Pro 
    290                 295                 300                 

Asp Thr Val Tyr Pro Phe Gly Met Ile Glu Asp Glu Trp Leu Pro Thr 
305                 310                 315                 320 

Pro Glu Tyr Val Leu Lys Thr Leu Asp Lys Val Met Ser Leu 
                325                 330                 

<210>   1269
<211>   334
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1259

<400>   1269
Met Pro Ala Arg Arg Arg Thr Asp Met Ala Gln Met Thr Met Ile Gln 
                5                   10                  15      

Ala Ile Thr His Ala Leu Asp Leu Glu Leu Ala Arg Asp Glu Arg Val 
            20                  25                  30          

Leu Val Phe Gly Glu Asp Val Gly Lys Asn Gly Gly Val Phe Arg Ala 
        35                  40                  45              

Thr Glu Gly Leu Gln Gln Lys Tyr Gly Pro Asn Arg Val Phe Asp Thr 
    50                  55                  60                  

Pro Leu Ala Glu Ser Gly Ile Ile Gly Leu Ala Asn Gly Leu Ala Ile 
65                  70                  75                  80  

Gln Gly Phe Arg Pro Val Pro Glu Ile Gln Phe Phe Gly Phe Val Phe 
                85                  90                  95      

Glu Ala Phe Asp Gln Ile Ala Gly Gln Leu Ala Arg Thr Arg Tyr Arg 
            100                 105                 110         

Thr Gly Gly Arg Tyr Thr Ala Pro Val Thr Ile Arg Ser Pro Phe Gly 
        115                 120                 125             

Gly Gly Val His Thr Pro Glu Met His Ala Asp Ser Leu Glu Gly Leu 
    130                 135                 140                 

Phe Val Gln Thr Pro Gly Ile Lys Val Val Ile Pro Ser Thr Pro Tyr 
145                 150                 155                 160 

Asp Ala Lys Gly Leu Leu Leu Ser Ala Ile Arg Asp Pro Asp Pro Val 
                165                 170                 175     

Ile Phe Leu Glu His Met Lys Leu Tyr Arg Ser Phe Arg Gln Glu Val 
            180                 185                 190         

Pro Glu Asp Asp Tyr Thr Ile Pro Leu Gly Val Ala Asn Val Val Arg 
        195                 200                 205             

Glu Gly Lys His Ala Thr Val Ile Ala Tyr Gly Ala Met Val His Val 
    210                 215                 220                 

Ala Leu Lys Ala Ala Glu Gln Trp Ser Lys Glu Arg Gly Leu Glu Ala 
225                 230                 235                 240 

Glu Val Ile Asp Leu Arg Thr Val Asn Pro Ile Asp Ile Asp Thr Ile 
                245                 250                 255     

Val Ala Ser Val Lys Lys Thr Asn Arg Ala Ile Val Val Gln Glu Ala 
            260                 265                 270         

Gln Arg Ser Ala Gly Ala Ala Ala Glu Ile Val Ala Gln Ile Asn Glu 
        275                 280                 285             

Asn Ala Ile Tyr Tyr Leu Glu Ala Pro Val Leu Arg Ala Thr Pro Pro 
    290                 295                 300                 

Asp Thr Val Tyr Pro Phe Gly Met Ile Glu Asp Glu Trp Leu Pro Thr 
305                 310                 315                 320 

Pro Glu Tyr Val Leu Lys Thr Leu Asp Lys Val Met Ser Leu 
                325                 330                 

<210>   1270
<211>   334
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1259

<400>   1270
Met Pro Ala Arg Arg Arg Thr Asp Met Ala Gln Met Thr Met Ile Gln 
                5                   10                  15      

Ala Ile Thr His Ala Leu Asp Leu Glu Leu Ala Arg Asp Glu Arg Val 
            20                  25                  30          

Leu Val Phe Gly Glu Asp Val Gly Lys Asn Gly Gly Val Phe Arg Ala 
        35                  40                  45              

Thr Glu Gly Leu Gln Gln Lys Tyr Gly Pro Asn Arg Val Phe Asp Thr 
    50                  55                  60                  

Pro Leu Ala Glu Ser Gly Ile Ile Gly Leu Ala Asn Gly Leu Ala Ile 
65                  70                  75                  80  

Gln Gly Phe Arg Pro Val Pro Glu Ile Gln Phe Phe Gly Phe Val Phe 
                85                  90                  95      

Glu Ala Phe Asp Gln Ile Ala Gly Gln Leu Ala Arg Thr Arg Tyr Arg 
            100                 105                 110         

Thr Gly Gly Lys Tyr Thr Ala Pro Val Thr Ile Arg Ser Pro Phe Gly 
        115                 120                 125             

Gly Gly Val His Thr Pro Glu Met His Ala Asp Ser Leu Glu Gly Leu 
    130                 135                 140                 

Phe Val Gln Thr Pro Gly Ile Lys Val Val Ile Pro Ser Thr Pro Tyr 
145                 150                 155                 160 

Asp Ala Lys Gly Leu Leu Leu Ser Ala Ile Arg Asp Pro Asp Pro Val 
                165                 170                 175     

Ile Phe Leu Glu His Met Lys Leu Tyr Arg Ser Phe Arg Gln Glu Val 
            180                 185                 190         

Pro Glu Asp Asp Tyr Thr Ile Pro Leu Gly Val Ala Asn Val Val Arg 
        195                 200                 205             

Glu Gly Lys His Ala Thr Val Ile Ala Tyr Gly Ala Met Val His Val 
    210                 215                 220                 

Ala Leu Lys Ala Ala Glu Gln Trp Ser Lys Glu Lys Gly Leu Glu Ala 
225                 230                 235                 240 

Glu Val Ile Asp Leu Arg Thr Val Asn Pro Ile Asp Ile Asp Thr Ile 
                245                 250                 255     

Val Ala Ser Val Lys Lys Thr Asn Arg Ala Ile Val Val Gln Glu Ala 
            260                 265                 270         

Gln Arg Ser Ala Gly Ala Ala Ala Glu Ile Val Ala Gln Ile Asn Glu 
        275                 280                 285             

Asn Ala Ile Tyr Tyr Leu Glu Ala Pro Val Leu Arg Ala Thr Pro Pro 
    290                 295                 300                 

Asp Thr Val Tyr Pro Phe Gly Met Ile Glu Asp Glu Trp Leu Pro Thr 
305                 310                 315                 320 

Pro Glu Tyr Val Leu Lys Thr Leu Asp Lys Val Met Ser Leu 
                325                 330                 

<210>   1271
<211>   1005
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1260

<400>   1271
ttgccggcga ggaaacgaac tgacatggcg cagatgacga tgattcaggc gatcacgcac       60

gccctcgatc tcgaactggc gcgcgacgag cgcgtgctcg tcttcggcga ggacgtcggc      120

aaaaacggcg gcgtcttccg cgcgaccgaa ggcctgcagc agaaatacgg gcccaaccgc      180

gtgttcgaca cgccgctcgc ggagagtggc atcatcggac tggccaacgg ccttgcgatt      240

caagggtttc gccccgtacc cgaaattcag ttttttgggt ttgtcttcga ggcgttcgac      300

cagatcgcgg gtcagctggc gcgcacgagg tatcgcaccg gcggccgcta caccgcgcct      360

gtgaccatcc gttctccgtt cggcggcggg gtgcacacgc ccgaaatgca cgcggattcc      420

ctggaaggcc tgtttgttca aacaccgggc atcaaggtgg tgattccgag cacgccctac      480

gacgccaagg gactgctgct gtcggccatt cgggacccgg atccagtcat cttcctggaa      540

cacatgaaac tgtatcgctc gttccgccag gaagtgccgg aggacgatta caccatcccg      600

ctcggcgtcg cgaacgtggt ccgagagggc aagcatgcca ccgtcatcgc ctatggggcc      660

atggtgcacg tggcgctgaa ggccgcggaa cagtggtcga aagaaaaggg cctcgaggcc      720

gaggtcatcg atcttcgcac cgtcaacccg attgacatcg ataccatcgt ggcgtcggtc      780

aagaagacga accgcgccat cgtcgtgcag gaagctcagc gttcggcggg cgccgcggcc      840

gagatcgtcg cgcaaatcaa cgaaaacgcg atttactact tggaagcacc ggttctccgc      900

gcaacgccgc ccgacacggt gtatccgttt ggtatgattg aggacgaatg gttgccgaca      960

cccgagtatg tcctcaagac gctcgataaa gtcatgagct tataa                     1005


<210>   1272
<211>   1005
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1260

<400>   1272
ttgccggcga ggaggcgaac tgacatggcg cagatgacga tgattcaggc gatcacgcac       60

gccctcgata ttgaactggc gcgcgacgag cgcgtgctcg tcttcggcga ggacgtcggc      120

aaaaacggcg gcgtcttccg cgcgaccgaa ggcctgcagc agaaatacgg gcccaaccgc      180

gtgttcgaca cgccgctcgc ggagagtggc atcatcggac tggccaacgg ccttgcgatt      240

caagggtttc gccccgtacc cgaaattcag ttttttgggt ttgtcttcga ggcgttcgac      300

cagatcgcgg gtcagctggc gcgcacgagg tatcgcaccg gcggccgcta caccgcgcct      360

gtgaccatcc gttctccgtt cggcggcggg gtgcacacgc ccgaaatgca cgcggattcc      420

ctggaaggcc tgtttgttca aacaccgggc atcaaggtgg tgattccgag cacgccctac      480

gacgccaagg gactgctgct gtcggccatt cgggacccgg atccagtcat cttcctggaa      540

cacatgaaac tgtatcgctc gttccgccag gaagtgccgg aggacgatta caccatcccg      600

ctcggcgtcg cgaacgtggt ccgagagggc aagcatgcca ccgtcatcgc ctatggggcc      660

atggtgcacg tggcgctgaa ggccgcggaa cagtggtcga aagaaaaggg cctcgaggcc      720

gaggtcatcg atcttcgcac cgtcaacccg attgacatcg ataccatcgt ggcgtcggtc      780

aagaagacga accgcgccat cgtcgtgcag gaagctcagc gttcggcggg cgccgcggcc      840

gagatcgtcg cgcaaatcaa cgaaaacgcg atttactact tggaagcacc ggttctccgc      900

gcaacgccgc ccgacacggt gtatccgttt ggtatgattg aggacgaatg gttgccgaca      960

cccgagtatg tcctcaagac gctcgataaa gtcatgagct tataa                     1005


<210>   1273
<211>   1005
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1260

<400>   1273
ttgccggcga ggaggcgaac tgacatggcg cagatgacga tgattcaggc gatcacgcac       60

gccctcgatc tcgaactggc gcgcgacgag cgcgtgctcg tcttcggcga ggacgtcggc      120

aaaaacggcg gcgtcttccg cgcgaccgaa ggcctgcagc agaaatacgg gcccaaccgc      180

gtgttcgaca cgccgctcgc ggagagtggc atcatcggac tggccaacgg ccttgcgatt      240

caagggtttc gccccgtacc cgaaattcag ttttttgggt ttgtcttcga ggcgttcgac      300

cagatcgcgg gtcagctggc gcgcacgagg tatcgcaccg gcggccgcta caccgcgcct      360

gtgaccatcc gttctccgtt cggcggcggg gtgcacacgc ccgaaatgca cgcggattcc      420

ctggaaggcc tgtttgttca aacaccgggc atcaaggtgg tgattccgag cacgccctac      480

gacgccaagg gactgctgct gtcggccatt cgggacccgg atccagtcat cttcctggaa      540

cacatgaaac tgtatcgctc gttccgccag gaagtgccgg aggacgatta caccatcccg      600

ctcggcgtcg cgaacgtggt ccgagagggc aagcatgcca ccgtcatcgc ctatggggcc      660

atggtgcaca ttgcgctgaa ggccgcggaa cagtggtcga aagaaaaggg cctcgaggcc      720

gaggtcatcg atcttcgcac cgtcaacccg attgacatcg ataccatcgt ggcgtcggtc      780

aagaagacga accgcgccat cgtcgtgcag gaagctcagc gttcggcggg cgccgcggcc      840

gagatcgtcg cgcaaatcaa cgaaaacgcg atttactact tggaagcacc ggttctccgc      900

gcaacgccgc ccgacacggt gtatccgttt ggtatgattg aggacgaatg gttgccgaca      960

cccgagtatg tcctcaagac gctcgataaa gtcatgagct tataa                     1005


<210>   1274
<211>   1005
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1260

<400>   1274
ttgccggcga ggaggcgaac tgacatggcg cagatgacga tgattcaggc gatcacgcac       60

gccctcgatc tcgaactggc gcgcgacgag cgcgtgctcg tcttcggcga ggacgtcggc      120

aaaaacggcg gcgtcttccg cgcgaccgaa ggcctgcagc agaaatacgg gcccaaccgc      180

gtgttcgaca cgccgctcgc ggagagtggc atcatcggac tggccaacgg ccttgcgatt      240

caagggtttc gccccgtacc cgaaattcag ttttttgggt ttgtcttcga ggcgttcgac      300

cagatcgcgg gtcagctggc gcgcacgagg tatcgcaccg gcggccgcta caccgcgcct      360

gtgaccatcc gttctccgtt cggcggcggg gtgcacacgc ccgaaatgca cgcggattcc      420

ctggaaggcc tgtttgttca aacaccgggc atcaaggtgg tgattccgag cacgccctac      480

gacgccaagg gactgctgct gtcggccatt cgggacccgg atccagtcat cttcctggaa      540

cacatgaaac tgtatcgctc gttccgccag gaagtgccgg aggacgatta caccatcccg      600

ctcggcgtcg cgaacgtggt ccgagagggc aagcatgcca ccgtcatcgc ctatggggcc      660

atggtgcacg tggcgctgaa ggccgcggaa cagtggtcga aagaacgtgg cctcgaggcc      720

gaggtcatcg atcttcgcac cgtcaacccg attgacatcg ataccatcgt ggcgtcggtc      780

aagaagacga accgcgccat cgtcgtgcag gaagctcagc gttcggcggg cgccgcggcc      840

gagatcgtcg cgcaaatcaa cgaaaacgcg atttactact tggaagcacc ggttctccgc      900

gcaacgccgc ccgacacggt gtatccgttt ggtatgattg aggacgaatg gttgccgaca      960

cccgagtatg tcctcaagac gctcgataaa gtcatgagct tataa                     1005


<210>   1275
<211>   1005
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1260

<400>   1275
ttgccggcga ggaggcgaac tgacatggcg cagatgacga tgattcaggc gatcacgcac       60

gccctcgatc tcgaactggc gcgcgacgag cgcgtgctcg tcttcggcga ggacgtcggc      120

aaaaacggcg gcgtcttccg cgcgaccgaa ggcctgcagc agaaatacgg gcccaaccgc      180

gtgttcgaca cgccgctcgc ggagagtggc atcatcggac tggccaacgg ccttgcgatt      240

caagggtttc gccccgtacc cgaaattcag ttttttgggt ttgtcttcga ggcgttcgac      300

cagatcgcgg gtcagctggc gcgcacgagg tatcgcaccg gcggcaaata caccgcgcct      360

gtgaccatcc gttctccgtt cggcggcggg gtgcacacgc ccgaaatgca cgcggattcc      420

ctggaaggcc tgtttgttca aacaccgggc atcaaggtgg tgattccgag cacgccctac      480

gacgccaagg gactgctgct gtcggccatt cgggacccgg atccagtcat cttcctggaa      540

cacatgaaac tgtatcgctc gttccgccag gaagtgccgg aggacgatta caccatcccg      600

ctcggcgtcg cgaacgtggt ccgagagggc aagcatgcca ccgtcatcgc ctatggggcc      660

atggtgcacg tggcgctgaa ggccgcggaa cagtggtcga aagaaaaggg cctcgaggcc      720

gaggtcatcg atcttcgcac cgtcaacccg attgacatcg ataccatcgt ggcgtcggtc      780

aagaagacga accgcgccat cgtcgtgcag gaagctcagc gttcggcggg cgccgcggcc      840

gagatcgtcg cgcaaatcaa cgaaaacgcg atttactact tggaagcacc ggttctccgc      900

gcaacgccgc ccgacacggt gtatccgttt ggtatgattg aggacgaatg gttgccgaca      960

cccgagtatg tcctcaagac gctcgataaa gtcatgagct tataa                     1005


<210>   1276
<211>   470
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1276
Met Val Val Gly Asp Ile Val Glu Glu Val Glu Val Leu Val Ile Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Lys Ser Val Thr Ile Val Asp Lys Ala Glu Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Arg Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Ala His His 
    50                  55                  60                  

Tyr Glu Ala Ala Lys Glu Ser Pro Phe Pro Gly Ile Glu Thr Thr Ala 
65                  70                  75                  80  

Thr Phe Asp Phe Lys Lys Val Gln Glu Trp Lys Gln Ser Val Val Lys 
                85                  90                  95      

Lys Met Thr Ser Gly Val Gln Gln Leu Leu Lys Gly Asn Lys Val Asn 
            100                 105                 110         

Val Ile His Gly Glu Ala Phe Phe Thr Lys Pro Asn Glu Val Arg Val 
        115                 120                 125             

Met Gln Glu Asn Gly Ser Gln Arg Leu Gln Phe Gln His Cys Ile Leu 
    130                 135                 140                 

Ala Thr Gly Ser Arg Pro Ile Glu Leu Lys Asn Leu Pro Leu Gly Lys 
145                 150                 155                 160 

Arg Val Ile Asp Ser Thr Gly Ala Leu Ser Leu Asp His Val Pro Lys 
                165                 170                 175     

Arg Leu Val Val Val Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly Gln 
            180                 185                 190         

Thr Phe Ala Lys Phe Gly Ser Gln Val Thr Ile Ile Glu Gly Leu Asp 
        195                 200                 205             

Ser Ile Leu Ala Leu Phe Asp Lys Gln Met Val Arg Leu Val Glu Lys 
    210                 215                 220                 

Asn Leu Lys Lys Tyr Asn Val Gln Ile Glu Thr Asn Ala Leu Ala Gln 
225                 230                 235                 240 

Gly Val Glu Glu Thr Glu Asp Gly Val Lys Leu Thr Tyr Lys Asp Lys 
                245                 250                 255     

Asp Gly Asn Glu Lys Thr Ile Glu Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Ile Gly Leu Gln Asp Ala Gly Ile 
        275                 280                 285             

Glu Leu Thr Asp Lys Gly Leu Val Lys Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Thr Asn Pro Asn Val Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Val Ile 
                325                 330                 335     

Ala Gly Lys Pro Ser Ile Val Asp Tyr Arg Cys Ile Pro Ser Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Met Ala Ser Val Gly Leu Thr Glu Glu Glu Ala 
        355                 360                 365             

Lys Lys Glu Tyr Gly Gln Val Ala Val Gly Arg Phe Pro Tyr Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Thr Ala Leu Asn Ala Thr Asp Gly Phe Ile Lys Leu 
385                 390                 395                 400 

Val Ala Asn Lys Glu Asn Gly Val Leu Val Gly Ala Gln Val Val Gly 
                405                 410                 415     

Val Glu Ala Ser Asn Ile Ile Ala Glu Leu Gly Leu Ala Ile Glu Met 
            420                 425                 430         

Ser Ala Thr Leu Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Met Val Met Glu Ala Ala Glu Val Gly Leu Gly Glu Pro 
    450                 455                 460                 

Ile His Ile Ile Lys Gly 
465                 470 

<210>   1277
<211>   1413
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1277
atggtagtcg gagatattgt ggaagaggtt gaggtcctcg tcattggcgc aggccctggc       60

ggttacgtgg cagccattcg ggctgcgcag ctcgggaagt cggtcaccat tgtggacaag      120

gccgagctgg gcggcgtgtg cctgaaccgc ggttgcattc cttccaaggc gctcatctcg      180

gccgcccatc actacgaggc ggccaaggag tcgccgttcc cgggcatcga gacgaccgca      240

accttcgatt tcaagaaagt gcaggaatgg aagcagtcgg ttgtcaaaaa gatgacgagc      300

ggcgtacagc agctcctgaa ggggaacaag gtcaacgtca tccacggcga agcatttttc      360

accaagccga acgaagtgcg cgtcatgcag gagaacggca gccagcggct gcagttccaa      420

cactgcatcc tggcgaccgg ctcgcggccc atcgagctga agaatttgcc gcttggcaag      480

cgcgtgattg actcgaccgg cgcgctctcg ctcgatcacg tcccgaagcg gctggtcgtg      540

gtgggcggcg gttacatcgg catcgagctc ggccagacgt tcgccaagtt cggaagccag      600

gtgaccatca tcgagggcct ggacagcatc ctcgcgctct ttgacaagca gatggtccgc      660

cttgtggaaa agaacctgaa gaagtacaac gtgcagattg agaccaacgc gctcgcgcag      720

ggcgtggagg agaccgagga cggcgtcaag ctcacctaca aggacaaaga cggcaacgag      780

aagaccattg aggcggacta cgtcctcgtg acagtgggtc gccgcccgaa cacggacgag      840

atcggcctgc aggacgcggg catcgagctg acggacaagg gcctcgtcaa ggtcgatcag      900

cagtgccgca ccaccaaccc gaacgtcttc gccatcgggg acatcgtgcc tggcccggcg      960

ctcgcccaca aggcgtcgta cgaaggcaag gtggccgcgg aggtcatcgc gggcaagccg     1020

tccatcgtcg actaccgctg catcccgtcc gtcgtcttct cggatccgga gatggcgtcg     1080

gtcggcctga ccgaggaaga ggcgaagaag gagtacggcc aggttgcggt cggccgcttc     1140

ccgtacgccg ccaacgggcg tgcgacggcg ctcaacgcga ccgacggctt catcaagctc     1200

gtcgccaaca aggagaacgg cgtgctcgtc ggcgcccagg tggttggcgt cgaggcgtcg     1260

aacatcatcg cggagctcgg gcttgccatc gagatgagcg caacgctcga ggacatcgcg     1320

ctgaccattc acgcccatcc cacgctcgga gagatggtca tggaagccgc cgaagtcggc     1380

ctcggcgagc cgattcacat catcaaggga taa                                  1413


<210>   1278
<211>   468
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1278
Met Val Val Gly Asp Phe Ala Ile Glu Thr Glu Thr Leu Val Val Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Gln Lys Val Thr Ile Val Glu Lys Ala Asn Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Gly His Arg 
    50                  55                  60                  

Tyr Glu Gln Ala Lys His Ser Glu Glu Met Gly Ile Lys Ala Glu Asn 
65                  70                  75                  80  

Val Thr Val Asp Phe Ser Lys Val Gln Glu Trp Lys Ala Ser Val Val 
                85                  90                  95      

Lys Lys Leu Thr Gly Gly Val Glu Gly Leu Leu Lys Gly Asn Lys Val 
            100                 105                 110         

Glu Ile Val Lys Gly Glu Ala Tyr Phe Val Asp Ala Asn Thr Val Arg 
        115                 120                 125             

Val Val Asn Gly Asp Ser Ala Gln Thr Tyr Thr Phe Lys Asn Ala Ile 
    130                 135                 140                 

Ile Ala Thr Gly Ser Arg Pro Ile Glu Leu Pro Asn Phe Lys Phe Ser 
145                 150                 155                 160 

Asn Arg Ile Leu Asp Ser Thr Gly Ala Leu Asn Leu Gly Glu Ile Pro 
                165                 170                 175     

Lys Ser Leu Val Val Ile Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly 
            180                 185                 190         

Thr Ala Tyr Ala Asn Phe Gly Ala Lys Val Thr Ile Leu Glu Gly Ala 
        195                 200                 205             

Gly Glu Ile Leu Ser Gly Phe Glu Lys Gln Met Ala Ala Ile Ile Lys 
    210                 215                 220                 

Arg Arg Leu Lys Lys Lys Gly Val Asp Ile Val Thr Asn Ala Leu Ala 
225                 230                 235                 240 

Lys Gly Ala Glu Glu Arg Glu Asp Gly Val Thr Val Thr Tyr Glu Ala 
                245                 250                 255     

Asn Gly Glu Thr Lys Thr Val Asp Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Leu Gly Leu Glu Gln Val Gly Ile 
        275                 280                 285             

Lys Met Thr Asp Arg Gly Leu Ile Glu Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Ser Val Pro Asn Ile Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Ala Ile 
                325                 330                 335     

Ala Gly His Pro Ser Val Val Asp Tyr Val Ala Ile Pro Ala Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Cys Ala Ser Val Gly Tyr Phe Glu Gln Gln Ala 
        355                 360                 365             

Lys Asp Glu Gly Ile Asp Val Ile Thr Ala Lys Phe Pro Phe Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Leu Ala Leu Asn Asp Thr Asp Gly Phe Leu Lys Leu 
385                 390                 395                 400 

Val Val Arg Lys Glu Asp Gly Val Val Ile Gly Ala Gln Ile Ile Gly 
                405                 410                 415     

Pro Asn Ala Ser Asp Met Ile Ala Glu Leu Gly Leu Ala Ile Glu Ala 
            420                 425                 430         

Gly Met Thr Ala Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Ile Ala Met Glu Gly Ala Glu Val Ala Leu Gly Thr Pro 
    450                 455                 460                 

Ile His Ile Ile 
465             

<210>   1279
<211>   468
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   1279
Met Val Val Gly Asp Phe Ala Ile Glu Thr Glu Thr Leu Val Val Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Gln Lys Val Thr Ile Val Glu Lys Gly Asn Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Ser His Arg 
    50                  55                  60                  

Tyr Glu Gln Ala Lys His Ser Glu Glu Met Gly Ile Lys Ala Glu Asn 
65                  70                  75                  80  

Val Thr Ile Asp Phe Ala Lys Val Gln Glu Trp Lys Ala Ser Val Val 
                85                  90                  95      

Lys Lys Leu Thr Gly Gly Val Glu Gly Leu Leu Lys Gly Asn Lys Val 
            100                 105                 110         

Glu Ile Val Lys Gly Glu Ala Tyr Phe Val Asp Ala Asn Thr Val Arg 
        115                 120                 125             

Val Val Asn Gly Asp Ser Ala Gln Thr Tyr Thr Phe Lys Asn Ala Ile 
    130                 135                 140                 

Ile Ala Thr Gly Ser Arg Pro Ile Glu Leu Pro Asn Phe Lys Phe Ser 
145                 150                 155                 160 

Asn Arg Ile Leu Asp Ser Thr Gly Ala Leu Asn Leu Gly Glu Val Pro 
                165                 170                 175     

Lys Ser Leu Val Val Ile Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly 
            180                 185                 190         

Thr Ala Tyr Ala Asn Phe Gly Thr Lys Val Thr Ile Leu Glu Gly Ala 
        195                 200                 205             

Gly Glu Ile Leu Ser Gly Phe Glu Lys Gln Met Ala Ala Ile Ile Lys 
    210                 215                 220                 

Lys Arg Leu Lys Lys Lys Gly Val Glu Val Val Thr Asn Ala Leu Ala 
225                 230                 235                 240 

Lys Gly Ala Glu Glu Arg Glu Asp Gly Val Thr Val Thr Tyr Glu Ala 
                245                 250                 255     

Asn Gly Glu Thr Lys Thr Ile Asp Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Leu Gly Leu Glu Gln Ile Gly Ile 
        275                 280                 285             

Lys Met Thr Asn Arg Gly Leu Ile Glu Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Ser Val Pro Asn Ile Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Ala Ile 
                325                 330                 335     

Ala Gly His Pro Ser Ala Val Asp Tyr Val Ala Ile Pro Ala Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Cys Ala Ser Val Gly Tyr Phe Glu Gln Gln Ala 
        355                 360                 365             

Lys Asp Glu Gly Ile Asp Val Ile Ala Ala Lys Phe Pro Phe Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Leu Ala Leu Asn Asp Thr Asp Gly Phe Leu Lys Leu 
385                 390                 395                 400 

Val Val Arg Lys Glu Asp Gly Val Ile Ile Gly Ala Gln Ile Ile Gly 
                405                 410                 415     

Pro Asn Ala Ser Asp Met Ile Ala Glu Leu Gly Leu Ala Ile Glu Ala 
            420                 425                 430         

Gly Met Thr Ala Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Ile Ala Met Glu Ala Ala Glu Val Ala Leu Gly Thr Pro 
    450                 455                 460                 

Ile His Ile Ile 
465             

<210>   1280
<211>   468
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1280
Met Val Val Gly Asp Phe Ala Ile Glu Thr Glu Thr Leu Val Val Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Gln Lys Val Thr Ile Val Glu Lys Gly Asn Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Ser His Arg 
    50                  55                  60                  

Tyr Glu Gln Ala Lys His Ser Glu Glu Met Gly Ile Lys Ala Glu Asn 
65                  70                  75                  80  

Val Thr Val Asp Phe Ser Lys Val Gln Glu Trp Lys Ala Ser Ile Val 
                85                  90                  95      

Lys Lys Leu Thr Gly Gly Val Glu Gly Leu Leu Lys Gly Asn Lys Val 
            100                 105                 110         

Asp Ile Val Lys Gly Glu Ala Tyr Phe Val Asp Ala Asn Thr Val Arg 
        115                 120                 125             

Val Val Asn Gly Asp Ser Ala Gln Thr Tyr Thr Phe Lys Asn Ala Ile 
    130                 135                 140                 

Leu Ala Thr Gly Ser Arg Pro Ile Glu Leu Pro Asn Phe Lys Phe Ser 
145                 150                 155                 160 

Gly Arg Ile Leu Asp Ser Thr Gly Ala Leu Asn Leu Gly Glu Ile Pro 
                165                 170                 175     

Lys Ser Leu Val Val Ile Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly 
            180                 185                 190         

Thr Ala Tyr Ala Asn Phe Gly Ala Lys Val Thr Ile Leu Glu Gly Ala 
        195                 200                 205             

Gly Glu Ile Leu Ser Gly Phe Glu Lys Gln Met Val Ser Ile Ile Lys 
    210                 215                 220                 

Arg Arg Leu Lys Asn Lys Gly Val Glu Val Val Thr Asn Ala Leu Ala 
225                 230                 235                 240 

Lys Gly Ala Glu Glu Arg Ala Asp Gly Val Thr Val Thr Tyr Glu Ala 
                245                 250                 255     

Asn Gly Glu Thr Lys Thr Ile Asp Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Leu Gly Leu Glu Gln Ile Gly Ile 
        275                 280                 285             

Lys Met Thr Asn Arg Gly Leu Ile Glu Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Ser Val Pro Asn Ile Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Ala Ile 
                325                 330                 335     

Ala Gly His Pro Ser Val Val Asp Tyr Ile Ala Ile Pro Ala Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Cys Ala Ser Val Gly Tyr Phe Glu Gln Gln Ala 
        355                 360                 365             

Lys Glu Glu Gly Ile Asp Val Ile Thr Ala Lys Phe Pro Phe Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Leu Ser Leu Asn Asp Thr Asp Gly Phe Leu Lys Leu 
385                 390                 395                 400 

Val Val Arg Lys Glu Asp Gly Val Val Ile Gly Ala Gln Ile Ile Gly 
                405                 410                 415     

Pro Asn Ala Ser Asp Met Ile Ala Glu Leu Gly Leu Ala Ile Glu Ala 
            420                 425                 430         

Gly Met Thr Ala Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Ile Ala Met Glu Ala Ala Glu Val Ala Leu Gly Thr Pro 
    450                 455                 460                 

Ile His Ile Ile 
465             

<210>   1281
<211>   470
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   1281
Met Val Val Gly Asp Phe Pro Ile Glu Thr Asp Thr Leu Val Ile Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Gln Lys Val Thr Ile Val Glu Lys Gly Thr Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Ile Asn Ala Gly His Arg 
    50                  55                  60                  

Phe Glu Asn Ala Lys His Ser Glu Asp Met Gly Ile Lys Ala Glu Asn 
65                  70                  75                  80  

Val Thr Val Asp Phe Thr Lys Val Gln Glu Trp Lys Ala Ser Val Val 
                85                  90                  95      

Asn Lys Leu Thr Gly Gly Val Gln Gly Leu Leu Lys Gly Asn Lys Val 
            100                 105                 110         

Asp Ile Val Lys Gly Glu Ala Tyr Phe Val Asp Ser Asn Ser Val Arg 
        115                 120                 125             

Val Met Asp Glu Asn Ser Ala Gln Thr Tyr Thr Phe Lys Asn Ala Ile 
    130                 135                 140                 

Leu Ala Thr Gly Ser Arg Pro Ile Glu Leu Pro Thr Phe Lys Tyr Thr 
145                 150                 155                 160 

Asp Arg Val Ile Asn Ser Thr Gly Ala Leu Ala Leu Lys Glu Val Pro 
                165                 170                 175     

Lys Lys Leu Val Val Ile Gly Gly Gly Tyr Ile Gly Thr Glu Leu Gly 
            180                 185                 190         

Thr Ala Tyr Ala Asn Phe Gly Thr Glu Val Val Ile Leu Glu Gly Gly 
        195                 200                 205             

Asp Glu Ile Leu Pro Gly Phe Glu Lys Gln Met Ser Ser Leu Val Lys 
    210                 215                 220                 

Arg Asn Leu Lys Lys Lys Gly Asn Val Glu Ile His Thr Asn Ala Leu 
225                 230                 235                 240 

Ala Lys Gly Val Glu Glu Lys Ser Asp Gly Val Thr Val Thr Phe Glu 
                245                 250                 255     

Val Lys Gly Glu Glu Lys Thr Val Asp Ala Asp Tyr Val Leu Val Thr 
            260                 265                 270         

Val Gly Arg Arg Pro Asn Thr Asp Glu Leu Gly Leu Glu Gln Val Gly 
        275                 280                 285             

Val Glu Leu Thr Asp Arg Gly Val Val Lys Thr Asp Lys Gln Cys Arg 
    290                 295                 300                 

Thr Ser Val Ser Asn Ile Tyr Ala Ile Gly Asp Ile Val Asp Gly Pro 
305                 310                 315                 320 

Pro Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Ile Ala Ala Glu Ala 
                325                 330                 335     

Ile Ala Gly Glu Pro Ala Glu Ile Asp Tyr Leu Gly Ile Pro Ala Val 
            340                 345                 350         

Val Phe Ser Glu Pro Glu Leu Ala Thr Val Gly Tyr Thr Glu Ala Glu 
        355                 360                 365             

Ala Lys Glu Glu Gly Ile Asp Ile Val Ala Ala Lys Phe Pro Phe Ala 
    370                 375                 380                 

Ala Asn Gly Arg Ala Leu Ser Leu Asp Ala Thr Asp Gly Phe Met Lys 
385                 390                 395                 400 

Met Ile Thr Arg Lys Glu Asp Gly Leu Val Ile Gly Ala Gln Ile Ala 
                405                 410                 415     

Gly Val Gly Ala Ser Asp Met Ile Ser Glu Leu Ser Leu Ala Ile Glu 
            420                 425                 430         

Ala Gly Val Thr Ala Glu Asp Ile Ala Met Thr Ile His Ala His Pro 
        435                 440                 445             

Thr Leu Gly Glu Ile Thr Met Glu Thr Ala Glu Val Ala Ile Gly Ser 
    450                 455                 460                 

Pro Ile His Ile Val Lys 
465                 470 

<210>   1282
<211>   453
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   1282
Glu Thr Glu Thr Leu Val Val Gly Ala Gly Pro Gly Gly Tyr Val Ala 
                5                   10                  15      

Ala Ile Arg Ala Ala Gln Leu Gly Gln Lys Val Thr Ile Val Glu Lys 
            20                  25                  30          

Gly Asn Leu Gly Gly Val Cys Leu Asn Val Gly Cys Ile Pro Ser Lys 
        35                  40                  45              

Ala Leu Ile Ser Ala Ser His Arg Tyr Glu Gln Ala Lys His Ser Glu 
    50                  55                  60                  

Glu Met Gly Ile Lys Ala Glu Asn Val Thr Ile Asp Phe Ala Lys Val 
65                  70                  75                  80  

Gln Glu Trp Lys Ala Ser Val Val Lys Lys Leu Thr Gly Gly Val Glu 
                85                  90                  95      

Gly Leu Leu Lys Gly Asn Lys Val Glu Ile Val Lys Gly Glu Ala Tyr 
            100                 105                 110         

Phe Val Asp Ala Asn Thr Val Arg Val Val Asn Gly Asp Ser Ala Gln 
        115                 120                 125             

Thr Tyr Thr Phe Lys Asn Ala Ile Ile Ala Thr Gly Ser Arg Pro Ile 
    130                 135                 140                 

Glu Leu Pro Asn Phe Lys Phe Ser Asn Arg Ile Leu Asp Ser Thr Gly 
145                 150                 155                 160 

Ala Leu Asn Leu Gly Glu Val Pro Lys Ser Leu Val Val Ile Gly Gly 
                165                 170                 175     

Gly Tyr Ile Gly Ile Glu Leu Gly Thr Ala Tyr Ala Asn Phe Gly Thr 
            180                 185                 190         

Lys Val Thr Ile Leu Glu Gly Ala Gly Glu Ile Leu Ser Gly Phe Glu 
        195                 200                 205             

Lys Gln Met Ala Ala Ile Ile Lys Lys Arg Leu Lys Lys Lys Gly Val 
    210                 215                 220                 

Glu Val Val Thr Asn Ala Leu Ala Lys Gly Ala Glu Glu Arg Glu Asp 
225                 230                 235                 240 

Gly Val Thr Val Thr Tyr Glu Ala Asn Gly Glu Thr Lys Thr Ile Asp 
                245                 250                 255     

Ala Asp Tyr Val Leu Val Thr Val Gly Arg Arg Pro Asn Thr Asp Glu 
            260                 265                 270         

Leu Gly Leu Glu Gln Ile Gly Ile Lys Met Thr Asn Arg Gly Leu Ile 
        275                 280                 285             

Glu Val Asp Gln Gln Cys Arg Thr Ser Val Pro Asn Ile Phe Ala Ile 
    290                 295                 300                 

Gly Asp Ile Val Pro Gly Pro Ala Leu Ala His Lys Ala Ser Tyr Glu 
305                 310                 315                 320 

Gly Lys Val Ala Ala Glu Ala Ile Ala Gly His Pro Ser Ala Val Asp 
                325                 330                 335     

Tyr Val Ala Ile Pro Ala Val Val Phe Ser Asp Pro Glu Cys Ala Ser 
            340                 345                 350         

Val Gly Tyr Phe Glu Gln Gln Ala Lys Asp Glu Gly Ile Asp Val Ile 
        355                 360                 365             

Ala Ala Lys Phe Pro Phe Ala Ala Asn Gly Arg Ala Leu Ala Leu Asn 
    370                 375                 380                 

Asp Thr Asp Gly Phe Leu Lys Leu Val Val Arg Lys Glu Asp Gly Val 
385                 390                 395                 400 

Ile Ile Gly Ala Gln Ile Ile Gly Pro Asn Ala Ser Asp Met Ile Ala 
                405                 410                 415     

Glu Leu Gly Leu Ala Ile Glu Ala Gly Met Thr Ala Glu Asp Ile Ala 
            420                 425                 430         

Leu Thr Ile His Ala His Pro Thr Leu Gly Glu Ile Ala Met Glu Ala 
        435                 440                 445             

Ala Glu Val Ala Leu 
    450             

<210>   1283
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1276

<400>   1283
Met Val Val Gly Asp Ile Val Glu Glu Val Glu Val Leu Val Ile Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Lys Ser Val Thr Ile Val Asp Lys Ala Glu Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Arg Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Ala His His 
    50                  55                  60                  

Tyr Glu Ala Ala Lys Glu Ser Pro Phe Pro Gly Ile Glu Thr Thr Ala 
65                  70                  75                  80  

Thr Phe Asp Phe Lys Lys Val Gln Glu Trp Lys Gln Ser Val Val Lys 
                85                  90                  95      

Lys Met Thr Ser Gly Val Gln Gln Leu Leu Lys Gly Asn Lys Val Asn 
            100                 105                 110         

Val Ile His Gly Glu Ala Phe Phe Thr Lys Pro Asn Glu Val Arg Val 
        115                 120                 125             

Met Gln Glu Asn Gly Ser Gln Arg Leu Gln Phe Gln His Cys Ile Leu 
    130                 135                 140                 

Ala Thr Gly Ser Arg Pro Ile Glu Leu Lys Asn Leu Pro Leu Gly Lys 
145                 150                 155                 160 

Arg Val Ile Asp Ser Thr Gly Ala Leu Ser Leu Asp His Val Pro Lys 
                165                 170                 175     

Arg Leu Val Val Val Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly Gln 
            180                 185                 190         

Thr Phe Ala Lys Phe Gly Ser Gln Val Thr Ile Ile Glu Gly Leu Asp 
        195                 200                 205             

Ser Ile Leu Ala Leu Phe Asp Lys Gln Met Val Arg Leu Val Glu Lys 
    210                 215                 220                 

Asn Leu Lys Lys Tyr Asn Val Gln Ile Glu Thr Asn Ala Leu Ala Gln 
225                 230                 235                 240 

Gly Val Glu Glu Thr Glu Asp Gly Val Lys Leu Thr Tyr Lys Asp Lys 
                245                 250                 255     

Asp Gly Asn Glu Lys Thr Ile Glu Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Ile Gly Leu Gln Asp Ala Gly Ile 
        275                 280                 285             

Glu Leu Thr Asp Lys Gly Leu Val Lys Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Thr Asn Pro Asn Val Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Val Ile 
                325                 330                 335     

Ala Gly Lys Pro Ser Ile Val Asp Tyr Arg Cys Ile Pro Ser Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Met Ala Ser Val Gly Leu Thr Glu Glu Glu Ala 
        355                 360                 365             

Lys Lys Glu Tyr Gly Gln Val Ala Val Gly Arg Phe Pro Tyr Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Thr Ala Leu Asn Ala Thr Asp Gly Phe Ile Lys Leu 
385                 390                 395                 400 

Val Ala Asn Lys Glu Asn Gly Val Leu Val Gly Ala Gln Val Val Gly 
                405                 410                 415     

Val Glu Ala Ser Asn Ile Ile Ala Glu Leu Gly Leu Ala Ile Glu Met 
            420                 425                 430         

Ser Ala Thr Leu Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Met Val Met Glu Ala Ala Glu Val Gly Leu Gly Glu Pro 
    450                 455                 460                 

Leu His Ile Ile Lys Gly 
465                 470 

<210>   1284
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1276

<400>   1284
Met Val Val Gly Asp Ile Val Glu Glu Val Glu Val Leu Val Ile Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Lys Ser Val Thr Ile Val Asp Lys Ala Glu Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Lys Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Ala His His 
    50                  55                  60                  

Tyr Glu Ala Ala Lys Glu Ser Pro Phe Pro Gly Ile Glu Thr Thr Ala 
65                  70                  75                  80  

Thr Phe Asp Phe Lys Lys Val Gln Glu Trp Lys Gln Ser Val Val Lys 
                85                  90                  95      

Lys Met Thr Ser Gly Val Gln Gln Leu Leu Lys Gly Asn Lys Val Asn 
            100                 105                 110         

Val Ile His Gly Glu Ala Phe Phe Thr Lys Pro Asn Glu Val Arg Val 
        115                 120                 125             

Met Gln Glu Asn Gly Ser Gln Arg Leu Gln Phe Gln His Cys Ile Leu 
    130                 135                 140                 

Ala Thr Gly Ser Arg Pro Ile Glu Leu Lys Asn Leu Pro Leu Gly Lys 
145                 150                 155                 160 

Arg Val Ile Asp Ser Thr Gly Ala Leu Ser Leu Asp His Val Pro Lys 
                165                 170                 175     

Arg Leu Val Val Val Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly Gln 
            180                 185                 190         

Thr Phe Ala Lys Phe Gly Ser Gln Val Thr Ile Ile Glu Gly Leu Asp 
        195                 200                 205             

Ser Ile Leu Ala Leu Phe Asp Lys Gln Met Val Arg Leu Val Glu Lys 
    210                 215                 220                 

Asn Leu Lys Lys Tyr Asn Val Gln Ile Glu Thr Asn Ala Leu Ala Gln 
225                 230                 235                 240 

Gly Val Glu Glu Thr Glu Asp Gly Val Lys Leu Thr Tyr Lys Asp Lys 
                245                 250                 255     

Asp Gly Asn Glu Lys Thr Ile Glu Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Ile Gly Leu Gln Asp Ala Gly Ile 
        275                 280                 285             

Glu Leu Thr Asp Lys Gly Leu Val Lys Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Thr Asn Pro Asn Val Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Val Ile 
                325                 330                 335     

Ala Gly Lys Pro Ser Ile Val Asp Tyr Arg Cys Ile Pro Ser Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Met Ala Ser Val Gly Leu Thr Glu Glu Glu Ala 
        355                 360                 365             

Lys Lys Glu Tyr Gly Gln Val Ala Val Gly Arg Phe Pro Tyr Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Thr Ala Leu Asn Ala Thr Asp Gly Phe Ile Lys Leu 
385                 390                 395                 400 

Val Ala Asn Lys Glu Asn Gly Val Leu Val Gly Ala Gln Val Val Gly 
                405                 410                 415     

Val Glu Ala Ser Asn Ile Ile Ala Glu Leu Gly Leu Ala Ile Glu Met 
            420                 425                 430         

Ser Ala Thr Leu Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Met Val Met Glu Ala Ala Glu Val Gly Leu Gly Glu Pro 
    450                 455                 460                 

Ile His Ile Ile Lys Gly 
465                 470 

<210>   1285
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1276

<400>   1285
Met Val Val Gly Asp Ile Val Glu Glu Val Glu Val Leu Val Ile Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Lys Ser Val Thr Ile Val Asp Lys Ala Glu Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Arg Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Ala His His 
    50                  55                  60                  

Tyr Glu Ala Ala Lys Glu Ser Pro Phe Pro Gly Ile Glu Thr Thr Ala 
65                  70                  75                  80  

Thr Phe Asp Phe Lys Lys Val Gln Glu Trp Lys Gln Ser Val Val Lys 
                85                  90                  95      

Lys Met Thr Ser Gly Val Gln Gln Leu Leu Lys Gly Asn Lys Val Asn 
            100                 105                 110         

Val Ile His Gly Glu Ala Phe Phe Thr Lys Pro Asn Glu Val Arg Val 
        115                 120                 125             

Met Gln Glu Asn Gly Ser Gln Arg Leu Gln Phe Gln His Cys Ile Leu 
    130                 135                 140                 

Ala Thr Gly Ser Arg Pro Ile Glu Leu Lys Asn Leu Pro Leu Gly Lys 
145                 150                 155                 160 

Arg Val Ile Asp Ser Thr Gly Ala Leu Ser Leu Asp His Val Pro Lys 
                165                 170                 175     

Arg Leu Val Val Val Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly Gln 
            180                 185                 190         

Thr Phe Ala Lys Phe Gly Ser Gln Val Thr Ile Ile Glu Gly Leu Asp 
        195                 200                 205             

Ser Ile Leu Ala Leu Phe Asp Lys Gln Met Ile Arg Leu Val Glu Lys 
    210                 215                 220                 

Asn Leu Lys Lys Tyr Asn Val Gln Ile Glu Thr Asn Ala Leu Ala Gln 
225                 230                 235                 240 

Gly Val Glu Glu Thr Glu Asp Gly Val Lys Leu Thr Tyr Lys Asp Lys 
                245                 250                 255     

Asp Gly Asn Glu Lys Thr Ile Glu Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Ile Gly Leu Gln Asp Ala Gly Ile 
        275                 280                 285             

Glu Leu Thr Asp Lys Gly Leu Val Lys Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Thr Asn Pro Asn Val Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Val Ile 
                325                 330                 335     

Ala Gly Lys Pro Ser Ile Val Asp Tyr Arg Cys Ile Pro Ser Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Met Ala Ser Val Gly Leu Thr Glu Glu Glu Ala 
        355                 360                 365             

Lys Lys Glu Tyr Gly Gln Val Ala Val Gly Arg Phe Pro Tyr Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Thr Ala Leu Asn Ala Thr Asp Gly Phe Ile Lys Leu 
385                 390                 395                 400 

Val Ala Asn Lys Glu Asn Gly Val Leu Val Gly Ala Gln Val Val Gly 
                405                 410                 415     

Val Glu Ala Ser Asn Ile Ile Ala Glu Leu Gly Leu Ala Ile Glu Met 
            420                 425                 430         

Ser Ala Thr Leu Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Met Val Met Glu Ala Ala Glu Val Gly Leu Gly Glu Pro 
    450                 455                 460                 

Ile His Ile Ile Lys Gly 
465                 470 

<210>   1286
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1276

<400>   1286
Met Val Val Gly Asp Ile Val Glu Glu Val Glu Val Leu Val Ile Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Lys Ser Val Thr Ile Val Asp Lys Ala Glu Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Arg Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Ala His His 
    50                  55                  60                  

Tyr Glu Ala Ala Lys Glu Ser Pro Phe Pro Gly Ile Glu Thr Thr Ala 
65                  70                  75                  80  

Thr Phe Asp Phe Lys Lys Val Gln Glu Trp Lys Gln Ser Val Val Lys 
                85                  90                  95      

Lys Met Thr Ser Gly Val Gln Gln Leu Leu Lys Gly Asn Lys Val Asn 
            100                 105                 110         

Val Ile His Gly Glu Ala Phe Phe Thr Lys Pro Asn Glu Val Arg Val 
        115                 120                 125             

Met Gln Glu Asn Gly Ser Gln Arg Leu Gln Phe Gln His Cys Ile Leu 
    130                 135                 140                 

Ala Thr Gly Ser Arg Pro Ile Glu Leu Lys Asn Leu Pro Leu Gly Lys 
145                 150                 155                 160 

Arg Val Ile Asp Ser Thr Gly Ala Leu Ser Leu Asp His Val Pro Lys 
                165                 170                 175     

Arg Leu Val Val Val Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly Gln 
            180                 185                 190         

Thr Phe Ala Lys Phe Gly Ser Gln Val Thr Ile Ile Glu Gly Leu Asp 
        195                 200                 205             

Ser Ile Leu Ala Leu Phe Asp Lys Gln Met Val Arg Leu Val Glu Lys 
    210                 215                 220                 

Asn Leu Lys Lys Tyr Asn Val Gln Ile Asp Thr Asn Ala Leu Ala Gln 
225                 230                 235                 240 

Gly Val Glu Glu Thr Glu Asp Gly Val Lys Leu Thr Tyr Lys Asp Lys 
                245                 250                 255     

Asp Gly Asn Glu Lys Thr Ile Glu Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Ile Gly Leu Gln Asp Ala Gly Ile 
        275                 280                 285             

Glu Leu Thr Asp Lys Gly Leu Val Lys Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Thr Asn Pro Asn Val Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Val Ile 
                325                 330                 335     

Ala Gly Lys Pro Ser Ile Val Asp Tyr Arg Cys Ile Pro Ser Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Met Ala Ser Val Gly Leu Thr Glu Glu Glu Ala 
        355                 360                 365             

Lys Lys Glu Tyr Gly Gln Val Ala Val Gly Arg Phe Pro Tyr Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Thr Ala Leu Asn Ala Thr Asp Gly Phe Ile Lys Leu 
385                 390                 395                 400 

Val Ala Asn Lys Glu Asn Gly Val Leu Val Gly Ala Gln Val Val Gly 
                405                 410                 415     

Val Glu Ala Ser Asn Ile Ile Ala Glu Leu Gly Leu Ala Ile Glu Met 
            420                 425                 430         

Ser Ala Thr Leu Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Met Val Met Glu Ala Ala Glu Val Gly Leu Gly Glu Pro 
    450                 455                 460                 

Ile His Ile Ile Lys Gly 
465                 470 

<210>   1287
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1276

<400>   1287
Met Val Val Gly Asp Ile Val Glu Glu Val Glu Val Leu Val Ile Gly 
                5                   10                  15      

Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Arg Ala Ala Gln Leu Gly 
            20                  25                  30          

Lys Ser Val Thr Ile Val Asp Lys Ala Glu Leu Gly Gly Val Cys Leu 
        35                  40                  45              

Asn Arg Gly Cys Ile Pro Ser Lys Ala Leu Ile Ser Ala Ala His His 
    50                  55                  60                  

Tyr Glu Ala Ala Lys Glu Ser Pro Phe Pro Gly Ile Glu Thr Thr Ala 
65                  70                  75                  80  

Thr Phe Asp Phe Lys Lys Val Gln Glu Trp Lys Gln Ser Val Val Lys 
                85                  90                  95      

Lys Met Thr Ser Gly Val Gln Gln Leu Leu Lys Gly Asn Lys Val Asn 
            100                 105                 110         

Val Ile His Gly Glu Ala Phe Phe Thr Lys Pro Asn Glu Val Arg Val 
        115                 120                 125             

Met Gln Glu Asn Gly Ser Gln Arg Leu Gln Phe Gln His Cys Ile Leu 
    130                 135                 140                 

Ala Thr Gly Ser Arg Pro Ile Glu Leu Lys Asn Leu Pro Ile Gly Lys 
145                 150                 155                 160 

Arg Val Ile Asp Ser Thr Gly Ala Leu Ser Leu Asp His Val Pro Lys 
                165                 170                 175     

Arg Leu Val Val Val Gly Gly Gly Tyr Ile Gly Ile Glu Leu Gly Gln 
            180                 185                 190         

Thr Phe Ala Lys Phe Gly Ser Gln Val Thr Ile Ile Glu Gly Leu Asp 
        195                 200                 205             

Ser Ile Leu Ala Leu Phe Asp Lys Gln Met Val Arg Leu Val Glu Lys 
    210                 215                 220                 

Asn Leu Lys Lys Tyr Asn Val Gln Ile Glu Thr Asn Ala Leu Ala Gln 
225                 230                 235                 240 

Gly Val Glu Glu Thr Glu Asp Gly Val Lys Leu Thr Tyr Lys Asp Lys 
                245                 250                 255     

Asp Gly Asn Glu Lys Thr Ile Glu Ala Asp Tyr Val Leu Val Thr Val 
            260                 265                 270         

Gly Arg Arg Pro Asn Thr Asp Glu Ile Gly Leu Gln Asp Ala Gly Ile 
        275                 280                 285             

Glu Leu Thr Asp Lys Gly Leu Val Lys Val Asp Gln Gln Cys Arg Thr 
    290                 295                 300                 

Thr Asn Pro Asn Val Phe Ala Ile Gly Asp Ile Val Pro Gly Pro Ala 
305                 310                 315                 320 

Leu Ala His Lys Ala Ser Tyr Glu Gly Lys Val Ala Ala Glu Val Ile 
                325                 330                 335     

Ala Gly Lys Pro Ser Ile Val Asp Tyr Arg Cys Ile Pro Ser Val Val 
            340                 345                 350         

Phe Ser Asp Pro Glu Met Ala Ser Val Gly Leu Thr Glu Glu Glu Ala 
        355                 360                 365             

Lys Lys Glu Tyr Gly Gln Val Ala Val Gly Arg Phe Pro Tyr Ala Ala 
    370                 375                 380                 

Asn Gly Arg Ala Thr Ala Leu Asn Ala Thr Asp Gly Phe Ile Lys Leu 
385                 390                 395                 400 

Val Ala Asn Lys Glu Asn Gly Val Leu Val Gly Ala Gln Val Val Gly 
                405                 410                 415     

Val Glu Ala Ser Asn Ile Ile Ala Glu Leu Gly Leu Ala Ile Glu Met 
            420                 425                 430         

Ser Ala Thr Leu Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr 
        435                 440                 445             

Leu Gly Glu Met Val Met Glu Ala Ala Glu Val Gly Leu Gly Glu Pro 
    450                 455                 460                 

Ile His Ile Ile Lys Gly 
465                 470 

<210>   1288
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1277

<400>   1288
atggtagtcg gagatattgt ggaagaggtt gaggtcctcg tcattggcgc aggccctggc       60

ggttacgtgg cagccattcg ggctgcgcag ctcgggaagt cggtcaccat tgtggacaag      120

gccgagctgg gcggcgtgtg cctgaaccgc ggttgcattc cttccaaggc gctcatctcg      180

gccgcccatc actacgaggc ggccaaggag tcgccgttcc cgggcatcga gacgaccgca      240

accttcgatt tcaagaaagt gcaggaatgg aagcagtcgg ttgtcaaaaa gatgacgagc      300

ggcgtacagc agctcctgaa ggggaacaag gtcaacgtca tccacggcga agcatttttc      360

accaagccga acgaagtgcg cgtcatgcag gagaacggca gccagcggct gcagttccaa      420

cactgcatcc tggcgaccgg ctcgcggccc atcgagctga agaatttgcc gcttggcaag      480

cgcgtgattg actcgaccgg cgcgctctcg ctcgatcacg tcccgaagcg gctggtcgtg      540

gtgggcggcg gttacatcgg catcgagctc ggccagacgt tcgccaagtt cggaagccag      600

gtgaccatca tcgagggcct ggacagcatc ctcgcgctct ttgacaagca gatggtccgc      660

cttgtggaaa agaacctgaa gaagtacaac gtgcagattg agaccaacgc gctcgcgcag      720

ggcgtggagg agaccgagga cggcgtcaag ctcacctaca aggacaaaga cggcaacgag      780

aagaccattg aggcggacta cgtcctcgtg acagtgggtc gccgcccgaa cacggacgag      840

atcggcctgc aggacgcggg catcgagctg acggacaagg gcctcgtcaa ggtcgatcag      900

cagtgccgca ccaccaaccc gaacgtcttc gccatcgggg acatcgtgcc tggcccggcg      960

ctcgcccaca aggcgtcgta cgaaggcaag gtggccgcgg aggtcatcgc gggcaagccg     1020

tccatcgtcg actaccgctg catcccgtcc gtcgtcttct cggatccgga gatggcgtcg     1080

gtcggcctga ccgaggaaga ggcgaagaag gagtacggcc aggttgcggt cggccgcttc     1140

ccgtacgccg ccaacgggcg tgcgacggcg ctcaacgcga ccgacggctt catcaagctc     1200

gtcgccaaca aggagaacgg cgtgctcgtc ggcgcccagg tggttggcgt cgaggcgtcg     1260

aacatcatcg cggagctcgg gcttgccatc gagatgagcg caacgctcga ggacatcgcg     1320

ctgaccattc acgcccatcc cacgctcgga gagatggtca tggaagccgc cgaagtcggc     1380

ctcggcgagc cgttacacat catcaaggga taa                                  1413


<210>   1289
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1277

<400>   1289
atggtagtcg gagatattgt ggaagaggtt gaggtcctcg tcattggcgc aggccctggc       60

ggttacgtgg cagccattcg ggctgcgcag ctcgggaagt cggtcaccat tgtggacaag      120

gccgagctgg gcggcgtgtg cctgaacaaa ggttgcattc cttccaaggc gctcatctcg      180

gccgcccatc actacgaggc ggccaaggag tcgccgttcc cgggcatcga gacgaccgca      240

accttcgatt tcaagaaagt gcaggaatgg aagcagtcgg ttgtcaaaaa gatgacgagc      300

ggcgtacagc agctcctgaa ggggaacaag gtcaacgtca tccacggcga agcatttttc      360

accaagccga acgaagtgcg cgtcatgcag gagaacggca gccagcggct gcagttccaa      420

cactgcatcc tggcgaccgg ctcgcggccc atcgagctga agaatttgcc gcttggcaag      480

cgcgtgattg actcgaccgg cgcgctctcg ctcgatcacg tcccgaagcg gctggtcgtg      540

gtgggcggcg gttacatcgg catcgagctc ggccagacgt tcgccaagtt cggaagccag      600

gtgaccatca tcgagggcct ggacagcatc ctcgcgctct ttgacaagca gatggtccgc      660

cttgtggaaa agaacctgaa gaagtacaac gtgcagattg agaccaacgc gctcgcgcag      720

ggcgtggagg agaccgagga cggcgtcaag ctcacctaca aggacaaaga cggcaacgag      780

aagaccattg aggcggacta cgtcctcgtg acagtgggtc gccgcccgaa cacggacgag      840

atcggcctgc aggacgcggg catcgagctg acggacaagg gcctcgtcaa ggtcgatcag      900

cagtgccgca ccaccaaccc gaacgtcttc gccatcgggg acatcgtgcc tggcccggcg      960

ctcgcccaca aggcgtcgta cgaaggcaag gtggccgcgg aggtcatcgc gggcaagccg     1020

tccatcgtcg actaccgctg catcccgtcc gtcgtcttct cggatccgga gatggcgtcg     1080

gtcggcctga ccgaggaaga ggcgaagaag gagtacggcc aggttgcggt cggccgcttc     1140

ccgtacgccg ccaacgggcg tgcgacggcg ctcaacgcga ccgacggctt catcaagctc     1200

gtcgccaaca aggagaacgg cgtgctcgtc ggcgcccagg tggttggcgt cgaggcgtcg     1260

aacatcatcg cggagctcgg gcttgccatc gagatgagcg caacgctcga ggacatcgcg     1320

ctgaccattc acgcccatcc cacgctcgga gagatggtca tggaagccgc cgaagtcggc     1380

ctcggcgagc cgattcacat catcaaggga taa                                  1413


<210>   1290
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1277

<400>   1290
atggtagtcg gagatattgt ggaagaggtt gaggtcctcg tcattggcgc aggccctggc       60

ggttacgtgg cagccattcg ggctgcgcag ctcgggaagt cggtcaccat tgtggacaag      120

gccgagctgg gcggcgtgtg cctgaaccgc ggttgcattc cttccaaggc gctcatctcg      180

gccgcccatc actacgaggc ggccaaggag tcgccgttcc cgggcatcga gacgaccgca      240

accttcgatt tcaagaaagt gcaggaatgg aagcagtcgg ttgtcaaaaa gatgacgagc      300

ggcgtacagc agctcctgaa ggggaacaag gtcaacgtca tccacggcga agcatttttc      360

accaagccga acgaagtgcg cgtcatgcag gagaacggca gccagcggct gcagttccaa      420

cactgcatcc tggcgaccgg ctcgcggccc atcgagctga agaatttgcc gcttggcaag      480

cgcgtgattg actcgaccgg cgcgctctcg ctcgatcacg tcccgaagcg gctggtcgtg      540

gtgggcggcg gttacatcgg catcgagctc ggccagacgt tcgccaagtt cggaagccag      600

gtgaccatca tcgagggcct ggacagcatc ctcgcgctct ttgacaagca gatgattcgc      660

cttgtggaaa agaacctgaa gaagtacaac gtgcagattg agaccaacgc gctcgcgcag      720

ggcgtggagg agaccgagga cggcgtcaag ctcacctaca aggacaaaga cggcaacgag      780

aagaccattg aggcggacta cgtcctcgtg acagtgggtc gccgcccgaa cacggacgag      840

atcggcctgc aggacgcggg catcgagctg acggacaagg gcctcgtcaa ggtcgatcag      900

cagtgccgca ccaccaaccc gaacgtcttc gccatcgggg acatcgtgcc tggcccggcg      960

ctcgcccaca aggcgtcgta cgaaggcaag gtggccgcgg aggtcatcgc gggcaagccg     1020

tccatcgtcg actaccgctg catcccgtcc gtcgtcttct cggatccgga gatggcgtcg     1080

gtcggcctga ccgaggaaga ggcgaagaag gagtacggcc aggttgcggt cggccgcttc     1140

ccgtacgccg ccaacgggcg tgcgacggcg ctcaacgcga ccgacggctt catcaagctc     1200

gtcgccaaca aggagaacgg cgtgctcgtc ggcgcccagg tggttggcgt cgaggcgtcg     1260

aacatcatcg cggagctcgg gcttgccatc gagatgagcg caacgctcga ggacatcgcg     1320

ctgaccattc acgcccatcc cacgctcgga gagatggtca tggaagccgc cgaagtcggc     1380

ctcggcgagc cgattcacat catcaaggga taa                                  1413


<210>   1291
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1277

<400>   1291
atggtagtcg gagatattgt ggaagaggtt gaggtcctcg tcattggcgc aggccctggc       60

ggttacgtgg cagccattcg ggctgcgcag ctcgggaagt cggtcaccat tgtggacaag      120

gccgagctgg gcggcgtgtg cctgaaccgc ggttgcattc cttccaaggc gctcatctcg      180

gccgcccatc actacgaggc ggccaaggag tcgccgttcc cgggcatcga gacgaccgca      240

accttcgatt tcaagaaagt gcaggaatgg aagcagtcgg ttgtcaaaaa gatgacgagc      300

ggcgtacagc agctcctgaa ggggaacaag gtcaacgtca tccacggcga agcatttttc      360

accaagccga acgaagtgcg cgtcatgcag gagaacggca gccagcggct gcagttccaa      420

cactgcatcc tggcgaccgg ctcgcggccc atcgagctga agaatttgcc gcttggcaag      480

cgcgtgattg actcgaccgg cgcgctctcg ctcgatcacg tcccgaagcg gctggtcgtg      540

gtgggcggcg gttacatcgg catcgagctc ggccagacgt tcgccaagtt cggaagccag      600

gtgaccatca tcgagggcct ggacagcatc ctcgcgctct ttgacaagca gatggtccgc      660

cttgtggaaa agaacctgaa gaagtacaac gtgcagattg ataccaacgc gctcgcgcag      720

ggcgtggagg agaccgagga cggcgtcaag ctcacctaca aggacaaaga cggcaacgag      780

aagaccattg aggcggacta cgtcctcgtg acagtgggtc gccgcccgaa cacggacgag      840

atcggcctgc aggacgcggg catcgagctg acggacaagg gcctcgtcaa ggtcgatcag      900

cagtgccgca ccaccaaccc gaacgtcttc gccatcgggg acatcgtgcc tggcccggcg      960

ctcgcccaca aggcgtcgta cgaaggcaag gtggccgcgg aggtcatcgc gggcaagccg     1020

tccatcgtcg actaccgctg catcccgtcc gtcgtcttct cggatccgga gatggcgtcg     1080

gtcggcctga ccgaggaaga ggcgaagaag gagtacggcc aggttgcggt cggccgcttc     1140

ccgtacgccg ccaacgggcg tgcgacggcg ctcaacgcga ccgacggctt catcaagctc     1200

gtcgccaaca aggagaacgg cgtgctcgtc ggcgcccagg tggttggcgt cgaggcgtcg     1260

aacatcatcg cggagctcgg gcttgccatc gagatgagcg caacgctcga ggacatcgcg     1320

ctgaccattc acgcccatcc cacgctcgga gagatggtca tggaagccgc cgaagtcggc     1380

ctcggcgagc cgattcacat catcaaggga taa                                  1413


<210>   1292
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1277

<400>   1292
atggtagtcg gagatattgt ggaagaggtt gaggtcctcg tcattggcgc aggccctggc       60

ggttacgtgg cagccattcg ggctgcgcag ctcgggaagt cggtcaccat tgtggacaag      120

gccgagctgg gcggcgtgtg cctgaaccgc ggttgcattc cttccaaggc gctcatctcg      180

gccgcccatc actacgaggc ggccaaggag tcgccgttcc cgggcatcga gacgaccgca      240

accttcgatt tcaagaaagt gcaggaatgg aagcagtcgg ttgtcaaaaa gatgacgagc      300

ggcgtacagc agctcctgaa ggggaacaag gtcaacgtca tccacggcga agcatttttc      360

accaagccga acgaagtgcg cgtcatgcag gagaacggca gccagcggct gcagttccaa      420

cactgcatcc tggcgaccgg ctcgcggccc atcgagctga agaatttgcc gattggcaag      480

cgcgtgattg actcgaccgg cgcgctctcg ctcgatcacg tcccgaagcg gctggtcgtg      540

gtgggcggcg gttacatcgg catcgagctc ggccagacgt tcgccaagtt cggaagccag      600

gtgaccatca tcgagggcct ggacagcatc ctcgcgctct ttgacaagca gatggtccgc      660

cttgtggaaa agaacctgaa gaagtacaac gtgcagattg agaccaacgc gctcgcgcag      720

ggcgtggagg agaccgagga cggcgtcaag ctcacctaca aggacaaaga cggcaacgag      780

aagaccattg aggcggacta cgtcctcgtg acagtgggtc gccgcccgaa cacggacgag      840

atcggcctgc aggacgcggg catcgagctg acggacaagg gcctcgtcaa ggtcgatcag      900

cagtgccgca ccaccaaccc gaacgtcttc gccatcgggg acatcgtgcc tggcccggcg      960

ctcgcccaca aggcgtcgta cgaaggcaag gtggccgcgg aggtcatcgc gggcaagccg     1020

tccatcgtcg actaccgctg catcccgtcc gtcgtcttct cggatccgga gatggcgtcg     1080

gtcggcctga ccgaggaaga ggcgaagaag gagtacggcc aggttgcggt cggccgcttc     1140

ccgtacgccg ccaacgggcg tgcgacggcg ctcaacgcga ccgacggctt catcaagctc     1200

gtcgccaaca aggagaacgg cgtgctcgtc ggcgcccagg tggttggcgt cgaggcgtcg     1260

aacatcatcg cggagctcgg gcttgccatc gagatgagcg caacgctcga ggacatcgcg     1320

ctgaccattc acgcccatcc cacgctcgga gagatggtca tggaagccgc cgaagtcggc     1380

ctcggcgagc cgattcacat catcaaggga taa                                  1413


<210>   1293
<211>   502
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1293
Met Ser Ile Arg Pro Asp Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Gln Phe Glu Val Lys Ala Glu Val Arg Asp Thr Gly Thr Val Leu 
            20                  25                  30          

Ser Val Gly Asp Gly Ile Ala Arg Leu Tyr Gly Leu Asp Asn Val Met 
        35                  40                  45              

Ala Gly Glu Leu Val Glu Phe Glu Ser Gly Val Tyr Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asp Asn Val Gly Val Val Val Leu Gly Ser Val Gln 
65                  70                  75                  80  

Gly Ile Arg Glu Gly Glu Gln Val Arg Arg Thr Gly Arg Leu Val Thr 
                85                  90                  95      

Val Pro Val Gly Pro Gln Leu Leu Gly Arg Val Val Asn Ala Leu Gly 
            100                 105                 110         

Gln Pro Ile Asp Asn Lys Gly Pro Ile Glu Ala Thr Glu Tyr Arg Pro 
        115                 120                 125             

Val Glu Ser Pro Ala Pro Gly Val Ile Val Arg Arg Ser Val His Glu 
    130                 135                 140                 

Pro Leu Glu Thr Gly Ile Lys Ala Ile Asp Ser Met Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ala Ile Ala Leu Asp Thr Ile Ile Asn Gln Lys Gly Lys Asp Val Lys 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Gln Ser Thr Val Ala Gln Val 
        195                 200                 205             

Val Glu Thr Leu Arg Arg Tyr Gly Ala Met Glu Tyr Thr Thr Val Val 
    210                 215                 220                 

Val Ala Ser Ala Ser Glu Pro Ala Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Cys Ala Met Ala Glu Tyr Tyr Leu Tyr Asn Gly Gln His Ala 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Asn Asp Glu His Gly Gly Gly Ser Leu Thr Ala Leu Pro Phe Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Glu Ser Asp Leu Phe Phe Ala Gly 
            340                 345                 350         

Val Arg Pro Ala Ile Asn Val Gly Ser Ser Val Ser Arg Val Gly Ser 
        355                 360                 365             

Ala Ala Gln Thr Lys Ala Met Lys Lys Val Ala Gly Thr Leu Lys Leu 
    370                 375                 380                 

Asp Leu Ala Gln Tyr Arg Glu Leu Gln Ala Phe Thr Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Asp Thr Leu Arg Arg Gly Glu Arg Met 
                405                 410                 415     

Thr Glu Leu Leu Lys Gln Pro Gln Tyr His Pro Leu Thr Phe Asp Arg 
            420                 425                 430         

Gln Val Ala Ser Leu Trp Thr Gly Val Asn Gly Tyr Leu Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Ala Val Gln Lys Phe Glu Arg Glu Trp Leu Ala Phe Leu 
    450                 455                 460                 

Asp Arg Glu Tyr Pro Gln Val Phe Gln Gln Met Gln Glu Arg Lys Ser 
465                 470                 475                 480 

Leu Glu Asp Asp Thr Ile Glu Leu Met Lys Glu Ala Met Ala Lys Phe 
                485                 490                 495     

Lys Pro Thr Phe Val Pro 
            500         

<210>   1294
<211>   1509
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1294
ttgagcattc gtccggatga aatcagcgcg ctcatcaagc aacagatcga gcagttcgag       60

gtcaaggccg aggtgcgcga cacgggcacg gtgctgtcgg tgggcgacgg cattgcgcgc      120

ctctatggct tggacaacgt catggcgggc gaactggtcg agttcgaaag cggcgtgtac      180

ggcatggcgc tgaacctgga ggaggacaac gtcggcgtcg tggtgctcgg gtccgtgcag      240

ggcatccgcg aaggcgaaca ggtgcgccgc accggacgct tggtcacggt gccggtgggt      300

ccgcagctct tggggcgcgt cgtgaacgcg ctgggtcaac ccattgacaa taagggcccc      360

attgaggcca cggagtatcg tcccgtcgag tcgccggcgc cgggcgtcat cgtgcgccgc      420

tctgtgcacg agccgctcga gacgggcatc aaggccatcg actcgatggt gcccatcgga      480

cgcggtcagc gcgagctgat catcggcgac cgccagacgg ggaaaacggc cattgcgctc      540

gacaccatca tcaaccaaaa gggcaaggac gtgaagtgca tctacgtcgc catcgggcag      600

aagcagtcca cggtggcgca agtcgtggag acgcttcgcc gctacggcgc gatggagtac      660

accaccgtgg tcgtggcgag cgcttcggag cccgctccgc tcctgttcct cgctccctac      720

gccgggtgcg cgatggcgga gtactacctg tacaacgggc agcacgcgct cgtggtgtac      780

gacgacctgt cgaagcaggc cgcggcatac cgcgagatgt cgctcttgct gcgccgcccg      840

ccgggccgcg aggcgtatcc gggagacgtg ttctatctgc attcgcgcct cttggagcgc      900

gccgcgaagc tgaacgacga gcacggcggc ggttcgctca cggccctgcc gttcattgag      960

acgcaggcgg gcgacatctc cgcgtacatc ccgaccaacg tcatctcgat cacggacggc     1020

cagatcttcc tcgagtcgga tctgttcttc gcgggcgtgc ggccggccat caacgtcgga     1080

tcgtcggtgt cccgcgtggg ctccgccgcg cagacgaagg ccatgaagaa ggtcgcgggc     1140

acgctgaagc tcgatctcgc ccagtaccgc gagctccagg ccttcaccca gttcggcagc     1200

gatctggaca aggcgacgca ggacaccctg cgccggggcg aacggatgac ggagctgttg     1260

aagcaaccgc agtatcaccc gctgacgttc gatcggcagg tcgcgtcgct ctggacgggc     1320

gtgaacggct atctggacga catcccggtc gaggccgtgc agaagttcga gcgcgagtgg     1380

ctcgccttct tggaccgcga gtatccgcag gtgttccaac agatgcagga gcgcaaatcg     1440

cttgaggacg ataccatcga gctcatgaaa gaagcgatgg cgaagttcaa gccgacgttt     1500

gtgccctga                                                             1509


<210>   1295
<211>   500
<212>   PRT
<213>   Bacillus sp. TA2.A1

<400>   1295
Met Ser Ile Arg Pro Glu Glu Ile Ser Ala Leu Ile Lys Lys Gln Ile 
                5                   10                  15      

Glu Asn Tyr Glu Ala Asp Leu Glu Val Val Glu Val Gly Thr Val Ile 
            20                  25                  30          

Gln Val Gly Asp Gly Ile Ala Arg Val His Gly Leu Glu Lys Val Met 
        35                  40                  45              

Ala Gly Glu Leu Leu Glu Phe Glu Asn Gly Val Met Gly Met Ala Gln 
    50                  55                  60                  

Asn Leu Glu Glu Asp Asn Val Gly Val Val Ile Leu Gly Pro Tyr Thr 
65                  70                  75                  80  

Glu Ile Arg Glu Gly Thr Gln Val Lys Arg Thr Gly Arg Ile Met Glu 
                85                  90                  95      

Val Pro Val Gly Glu Ala Leu Leu Gly Arg Val Val Asn Pro Leu Gly 
            100                 105                 110         

Gln Pro Leu Asp Gly Arg Gly Pro Ile Glu Thr Ala Glu Tyr Arg Pro 
        115                 120                 125             

Ile Glu Ser Pro Ala Pro Gly Val Met Asp Arg Lys Ser Val His Glu 
    130                 135                 140                 

Pro Leu Gln Thr Gly Ile Lys Ala Ile Asp Ser Met Ile Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Thr Ile Ala Ile Asp Thr Ile Ile Asn Gln Lys Gly Gln Asp Val Ile 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Gln Ser Thr Val Ala Gly Val 
        195                 200                 205             

Val Glu Thr Leu Arg Gln His Asp Ala Leu Asp Tyr Thr Ile Val Val 
    210                 215                 220                 

Thr Ala Ser Ala Ser Glu Pro Ala Pro Leu Leu Tyr Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Cys Ala Met Gly Glu Tyr Phe Met Tyr Lys Gly Lys His Ala 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Leu Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Ser Asp Glu Lys Gly Gly Gly Ser Leu Thr Ala Leu Pro Phe Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Glu Ser Asp Leu Phe Tyr Ser Gly 
            340                 345                 350         

Val Arg Pro Ala Val Asn Val Gly Ile Ser Val Ser Arg Val Gly Gly 
        355                 360                 365             

Ala Ala Gln Ile Lys Ala Met Lys Lys Val Ala Gly Thr Leu Arg Leu 
    370                 375                 380                 

Asp Leu Ala Gln Tyr Arg Glu Leu Gln Ala Phe Ala Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Ala Lys Leu Asn Arg Gly Glu Arg Thr 
                405                 410                 415     

Val Glu Ile Leu Lys Gln Asp Glu His Lys Pro Met Pro Val Glu Glu 
            420                 425                 430         

Gln Val Ile Ser Ile Tyr Ala Val Thr Asn Gly Phe Met Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Asp Val Arg Arg Phe Glu Glu Glu Leu Leu Ser Phe Met 
    450                 455                 460                 

Arg Ala Asn Lys Asp Ser Leu Leu Asp His Ile Arg Gln Thr Gly Glu 
465                 470                 475                 480 

Leu Pro Asp Thr Lys Glu Leu Asp Ala Ala Ile Glu Glu Phe Lys Lys 
                485                 490                 495     

Gly Phe Thr Pro 
            500 

<210>   1296
<211>   500
<212>   PRT
<213>   Carboxydothermus hydrogenoformans Z-2901

<400>   1296
Met Asn Leu Arg Pro Glu Glu Ile Gly Ser Ile Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Asn Tyr Gln Val Gln Val Glu Val Ser Ser Val Gly Thr Val Ile 
            20                  25                  30          

Gln Val Gly Asp Gly Ile Ala Arg Val Tyr Gly Leu Glu Asp Cys Met 
        35                  40                  45              

Ala Ser Glu Leu Leu Glu Phe Pro Gly Gly Val Leu Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asp Asn Val Gly Cys Val Ile Leu Gly Pro Tyr Thr 
65                  70                  75                  80  

His Ile Lys Glu Gly Asp Thr Val Lys Arg Thr Gly Arg Val Val Ser 
                85                  90                  95      

Val Pro Val Gly Glu Ala Leu Ile Gly Arg Val Val Asn Pro Leu Gly 
            100                 105                 110         

Gln Pro Leu Asp Gly Lys Gly Pro Ile Val Thr Asp Lys Phe Arg Pro 
        115                 120                 125             

Val Glu Arg Ile Ala Pro Gly Val Ile Thr Arg Lys Ser Val His Glu 
    130                 135                 140                 

Pro Leu Gln Thr Gly Ile Lys Ala Ile Asp Ser Met Ile Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ala Ile Ala Ile Asp Thr Ile Ile Asn Gln Lys Asn Thr Asp Val Ile 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Ala Ser Thr Val Ala Lys Val 
        195                 200                 205             

Val Gln Thr Leu Lys Asp His Gly Ala Met Asp Tyr Thr Ile Val Val 
    210                 215                 220                 

Ser Ala Thr Ala Ser Asp Pro Ala Pro Leu Leu Tyr Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Cys Ala Met Gly Glu Glu Phe Met Glu Gln Gly Lys His Val 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Leu Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Ser Asp Glu Tyr Gly Gly Gly Ser Leu Thr Ala Leu Pro Ile Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Tyr Leu Glu Ser Asp Leu Phe Tyr Ala Gly 
            340                 345                 350         

Val Arg Pro Ala Val Asn Val Gly Leu Ser Val Ser Arg Val Gly Gly 
        355                 360                 365             

Ala Ala Gln Ile Lys Ala Met Lys Gln Val Ala Gly Ser Leu Arg Leu 
    370                 375                 380                 

Asp Leu Ala Gln Tyr Arg Glu Leu Ala Ala Phe Ala Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Leu Ala Arg Leu Thr Arg Gly Glu Arg Leu 
                405                 410                 415     

Val Glu Leu Leu Lys Gln Asp Gln Tyr Lys Pro Met Pro Val Glu Glu 
            420                 425                 430         

Gln Val Met Ala Ile Phe Ala Ala Val Asn Gly Tyr Leu Asp Asp Leu 
        435                 440                 445             

Pro Val Glu Lys Val Arg Pro Phe Glu Ala Glu Phe Leu Lys Phe Met 
    450                 455                 460                 

Arg Ala Asn Tyr Pro Gln Ile Gly Glu Glu Ile Arg Thr Lys Gly Val 
465                 470                 475                 480 

Leu Thr Asp Glu Leu Thr Ser Arg Leu Lys Ser Ala Ile Glu Glu Phe 
                485                 490                 495     

Lys Lys Thr Phe 
            500 

<210>   1297
<211>   499
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1297
Met Ser Ile Arg Ala Glu Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Asn Tyr Glu Ser Gln Ile Gln Val Ser Asp Val Gly Thr Val Ile 
            20                  25                  30          

Gln Ile Gly Asp Gly Ile Ala Arg Val His Gly Leu Asp Asn Val Met 
        35                  40                  45              

Ser Gly Glu Leu Val Glu Phe Ala Asn Gly Val Met Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asn Asn Val Gly Ile Val Ile Leu Gly Pro Tyr Thr 
65                  70                  75                  80  

Gly Ile Lys Glu Gly Asp Glu Val Arg Arg Thr Gly Arg Ile Met Glu 
                85                  90                  95      

Val Pro Val Gly Glu Ala Leu Ile Gly Arg Val Val Asn Pro Leu Gly 
            100                 105                 110         

Gln Pro Val Asp Gly Leu Gly Pro Val Glu Thr Thr Glu Thr Arg Pro 
        115                 120                 125             

Ile Glu Ser Pro Ala Pro Gly Val Met Asp Arg Lys Ser Val His Glu 
    130                 135                 140                 

Pro Leu Gln Thr Gly Ile Lys Ala Ile Asp Ala Leu Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ala Val Ala Ile Asp Thr Ile Leu Asn Gln Lys Gly Gln Asp Met Ile 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Glu Ser Thr Val Arg Thr Val 
        195                 200                 205             

Val Glu Thr Leu Arg Lys His Gly Ala Leu Asp Tyr Thr Ile Val Val 
    210                 215                 220                 

Thr Ala Ser Ala Ser Gln Pro Ala Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Val Ser Met Gly Glu Tyr Phe Met Tyr Lys Gly Lys His Val 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Leu Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Ser Asp Ala Lys Gly Ala Gly Ser Leu Thr Ala Leu Pro Phe Val Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Gln Ser Asp Leu Phe Phe Ser Gly 
            340                 345                 350         

Val Arg Pro Ala Ile Asn Ala Gly Leu Ser Val Ser Arg Val Gly Gly 
        355                 360                 365             

Ala Ala Gln Ile Lys Ala Met Lys Lys Val Ser Gly Thr Leu Arg Leu 
    370                 375                 380                 

Asp Leu Ala Ala Tyr Arg Glu Leu Glu Ala Phe Ala Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Ala Lys Leu Ala Arg Gly Ala Arg Thr 
                405                 410                 415     

Val Glu Val Leu Lys Gln Asp Leu His Gln Pro Ile Pro Val Glu Lys 
            420                 425                 430         

Gln Val Ala Ile Ile Tyr Ala Leu Thr Arg Gly Phe Leu Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Asp Val Arg Arg Phe Glu Lys Glu Phe Phe Leu Trp Leu 
    450                 455                 460                 

Asp Gln Asn Gly Gln His Leu Leu Glu His Ile Arg Thr Thr Lys Asp 
465                 470                 475                 480 

Leu Pro Asn Glu Glu Asp Phe Asn Lys Ala Ile Glu Ala Phe Lys Lys 
                485                 490                 495     

Thr Phe Val 
            

<210>   1298
<211>   499
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1298
Met Ser Ile Arg Ala Glu Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Asn Tyr Glu Ser Gln Ile Gln Val Ser Asp Val Gly Thr Val Ile 
            20                  25                  30          

Gln Val Gly Asp Gly Ile Ala Arg Ala His Gly Leu Asp Asn Val Met 
        35                  40                  45              

Ser Gly Glu Leu Val Glu Phe Ala Asn Gly Val Met Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asn Asn Val Gly Ile Val Ile Leu Gly Pro Tyr Thr 
65                  70                  75                  80  

Gly Ile Lys Glu Gly Asp Glu Val Arg Arg Thr Gly Arg Ile Met Glu 
                85                  90                  95      

Val Pro Val Gly Glu Ala Leu Ile Gly Arg Val Val Asn Pro Leu Gly 
            100                 105                 110         

Gln Pro Val Asp Gly Leu Gly Pro Val Glu Thr Thr Glu Thr Arg Pro 
        115                 120                 125             

Ile Glu Ser Pro Ala Pro Gly Val Met Asp Arg Arg Ser Val His Glu 
    130                 135                 140                 

Pro Leu Gln Thr Gly Ile Lys Ala Ile Asp Ala Leu Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ser Val Ala Ile Asp Thr Ile Ile Asn Gln Lys Asp Gln Asn Met Ile 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Glu Ser Thr Val Arg Thr Val 
        195                 200                 205             

Val Glu Thr Leu Arg Lys His Gly Ala Leu Asp Tyr Thr Ile Val Val 
    210                 215                 220                 

Thr Ala Ser Ala Ser Gln Pro Ala Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Val Ala Met Gly Glu Tyr Phe Met Tyr Lys Gly Gln His Val 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Leu Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Ile Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Ser Asp Ala Lys Gly Gly Gly Ser Leu Thr Ala Leu Pro Phe Val Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Gln Ser Asp Leu Phe Phe Ser Gly 
            340                 345                 350         

Val Arg Pro Ala Ile Asn Ala Gly Leu Ser Val Ser Arg Val Gly Gly 
        355                 360                 365             

Ala Ala Gln Ile Lys Ala Met Lys Lys Val Ala Gly Thr Leu Arg Leu 
    370                 375                 380                 

Asp Leu Ala Ala Tyr Arg Glu Leu Glu Ala Phe Ala Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Ala Lys Leu Ala Arg Gly Ala Arg Thr 
                405                 410                 415     

Val Glu Val Leu Lys Gln Asp Leu His Gln Pro Ile Pro Val Glu Lys 
            420                 425                 430         

Gln Val Leu Ile Ile Tyr Ala Leu Thr Arg Gly Phe Leu Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Asp Val Arg Arg Phe Glu Lys Glu Phe Tyr Leu Trp Leu 
    450                 455                 460                 

Asp Gln Asn Gly Gln His Leu Leu Glu His Ile Arg Thr Thr Lys Asp 
465                 470                 475                 480 

Leu Pro Asn Glu Asp Asp Leu Asn Lys Ala Ile Glu Ala Phe Lys Lys 
                485                 490                 495     

Thr Phe Val 
            

<210>   1299
<211>   498
<212>   PRT
<213>   Nitratiruptor sp. SB155-2

<400>   1299
Leu Gln Ala Asp Glu Ile Ser Ser Ile Ile Lys Glu Arg Ile Glu Asp 
                5                   10                  15      

Phe Glu Leu Lys Ile Asp Val Glu Glu Thr Gly Lys Val Ile Ser Phe 
            20                  25                  30          

Gly Asp Gly Val Ala Lys Val Phe Gly Leu Asn Asn Val Met Ala Gly 
        35                  40                  45              

Glu Met Leu Glu Phe Asp Asn Gly Asp Lys Gly Met Ala Leu Asn Leu 
    50                  55                  60                  

Glu Glu Thr Asn Val Gly Val Val Val Leu Gly Arg Gly Glu Gly Ile 
65                  70                  75                  80  

Arg Glu Gly Ser Ser Val Lys Arg Leu Gly Gln Leu Leu Lys Ala Pro 
                85                  90                  95      

Val Gly Glu Ala Leu Val Gly Arg Val Ile Asn Ala Ile Gly Glu Pro 
            100                 105                 110         

Ile Asp Gly Lys Gly Pro Ile Glu Ala Thr Glu Tyr Arg Tyr Val Glu 
        115                 120                 125             

Glu Lys Ala Pro Gly Ile Met Ala Arg Lys Ser Val His Glu Pro Leu 
    130                 135                 140                 

Gln Thr Gly Ile Lys Ala Ile Asp Ala Leu Val Pro Ile Gly Arg Gly 
145                 150                 155                 160 

Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Thr Val 
                165                 170                 175     

Ala Ile Asp Thr Ile Ile Asn Gln Lys Gly Gln Asp Val Val Cys Ile 
            180                 185                 190         

Tyr Val Ala Val Gly Gln Lys Gln Ser Thr Val Ala Gln Val Val Lys 
        195                 200                 205             

Lys Leu Glu Glu His Gly Ala Met Asp Tyr Thr Ile Val Val Asn Ala 
    210                 215                 220                 

Gly Ala Ser Glu Pro Ala Ala Leu Gln Phe Leu Ala Pro Tyr Thr Gly 
225                 230                 235                 240 

Val Thr Ile Gly Glu Tyr Phe Arg Asp Asn Gly Lys His Ala Leu Ile 
                245                 250                 255     

Val Tyr Asp Asp Leu Ser Lys His Ala Val Ala Tyr Arg Glu Met Ser 
            260                 265                 270         

Leu Ile Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly Asp Val 
        275                 280                 285             

Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu Asn Asp 
    290                 295                 300                 

Lys Leu Gly Ala Gly Ser Leu Thr Ala Leu Pro Ile Ile Glu Thr Gln 
305                 310                 315                 320 

Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser Ile Thr 
                325                 330                 335     

Asp Gly Gln Ile Phe Leu Glu Ser Asp Leu Phe Asn Ala Gly Ile Arg 
            340                 345                 350         

Pro Ala Ile Asn Val Gly Ile Ser Val Ser Arg Val Gly Gly Ala Ala 
        355                 360                 365             

Gln Ile Lys Ala Met Lys Gln Val Ala Gly Thr Leu Arg Leu Asp Leu 
    370                 375                 380                 

Ala Gln Tyr Arg Glu Leu Glu Ala Phe Ala Gln Phe Ala Ser Asp Leu 
385                 390                 395                 400 

Asp Glu Ala Ser Arg Lys Gln Leu Glu Arg Gly Met Arg Met Val Glu 
                405                 410                 415     

Ile Leu Lys Gln Pro Pro Tyr Ser Pro Leu Pro Val Glu Lys Gln Val 
            420                 425                 430         

Val Ile Ile Tyr Ala Gly Ala Asn Gly Phe Leu Asp Asp Ile Glu Val 
        435                 440                 445             

Ser Ala Ile Gly Lys Phe Glu Tyr Glu Leu Tyr Ser Phe Ile Glu Ala 
    450                 455                 460                 

Lys Tyr Pro Gln Ile Phe Glu Leu Ile Arg Glu Arg Lys Ala Leu Asp 
465                 470                 475                 480 

Asp Glu Ile Lys Glu Leu Leu Asn Lys Ala Ile Glu Glu Phe Lys Ala 
                485                 490                 495     

Ser Phe 
        

<210>   1300
<211>   502
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1293

<400>   1300
Met Ser Ile Arg Pro Asp Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Gln Phe Glu Val Lys Ala Glu Val Arg Asp Thr Gly Thr Val Leu 
            20                  25                  30          

Ser Val Gly Asp Gly Ile Ala Arg Leu Tyr Gly Leu Asp Asn Val Met 
        35                  40                  45              

Ala Gly Glu Leu Val Glu Phe Glu Ser Gly Val Tyr Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asp Asn Val Gly Val Val Val Leu Gly Ser Val Asn 
65                  70                  75                  80  

Gly Ile Arg Glu Gly Glu Gln Val Arg Arg Thr Gly Arg Leu Val Thr 
                85                  90                  95      

Val Pro Val Gly Pro Gln Leu Leu Gly Arg Val Val Asn Ala Leu Gly 
            100                 105                 110         

Gln Pro Ile Asp Asn Lys Gly Pro Ile Glu Ala Thr Glu Tyr Arg Pro 
        115                 120                 125             

Val Glu Ser Pro Ala Pro Gly Val Ile Val Arg Arg Ser Val His Glu 
    130                 135                 140                 

Pro Leu Glu Thr Gly Ile Lys Ala Ile Asp Ser Met Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ala Ile Ala Leu Asp Thr Ile Ile Asn Gln Lys Gly Lys Asp Val Lys 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Gln Ser Thr Val Ala Gln Val 
        195                 200                 205             

Val Glu Thr Leu Arg Arg Tyr Gly Ala Met Glu Tyr Thr Thr Val Val 
    210                 215                 220                 

Val Ala Ser Ala Ser Glu Pro Ala Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Cys Ala Met Ala Glu Tyr Tyr Leu Tyr Asn Gly Gln His Ala 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Asn Asp Glu His Gly Gly Gly Ser Leu Thr Ala Leu Pro Phe Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Glu Ser Asp Leu Phe Phe Ala Gly 
            340                 345                 350         

Val Arg Pro Ala Ile Asn Val Gly Ser Ser Val Ser Arg Val Gly Ser 
        355                 360                 365             

Ala Ala Gln Thr Lys Ala Met Lys Lys Val Ala Gly Thr Leu Lys Leu 
    370                 375                 380                 

Asp Leu Ala Gln Tyr Arg Glu Leu Gln Ala Phe Thr Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Asp Thr Leu Arg Arg Gly Glu Arg Met 
                405                 410                 415     

Thr Glu Leu Leu Lys Gln Pro Gln Tyr His Pro Leu Thr Phe Asp Arg 
            420                 425                 430         

Gln Val Ala Ser Leu Trp Thr Gly Val Asn Gly Tyr Leu Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Ala Val Gln Lys Phe Glu Arg Glu Trp Leu Ala Phe Leu 
    450                 455                 460                 

Asp Arg Glu Tyr Pro Gln Val Phe Gln Gln Met Gln Glu Arg Lys Ser 
465                 470                 475                 480 

Leu Glu Asp Asp Thr Ile Glu Leu Met Lys Glu Ala Met Ala Lys Phe 
                485                 490                 495     

Lys Pro Thr Phe Val Pro 
            500         

<210>   1301
<211>   502
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1293

<400>   1301
Met Ser Ile Arg Pro Asp Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Gln Phe Glu Val Lys Ala Glu Val Arg Asp Thr Gly Thr Val Leu 
            20                  25                  30          

Ser Val Gly Asp Gly Ile Ala Arg Leu Tyr Gly Leu Asp Asn Val Met 
        35                  40                  45              

Ala Gly Glu Leu Val Glu Phe Glu Ser Gly Val Tyr Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asp Asn Val Gly Val Val Val Leu Gly Ser Val Gln 
65                  70                  75                  80  

Gly Ile Arg Glu Gly Glu Gln Val Arg Arg Thr Gly Arg Leu Val Thr 
                85                  90                  95      

Val Pro Val Gly Pro Gln Leu Leu Gly Arg Val Val Asn Ala Leu Gly 
            100                 105                 110         

Gln Pro Ile Asp Asn Lys Gly Pro Ile Glu Ala Thr Glu Tyr Arg Pro 
        115                 120                 125             

Val Glu Ser Pro Ala Pro Gly Val Ile Val Arg Arg Ser Val His Glu 
    130                 135                 140                 

Pro Leu Glu Thr Gly Ile Lys Ala Ile Asp Ser Met Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ala Ile Ala Leu Asp Thr Ile Ile Asn Gln Lys Gly Lys Asp Val Lys 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Gln Ser Thr Val Ala Gln Val 
        195                 200                 205             

Val Glu Thr Leu Arg Arg Tyr Gly Ala Met Glu Tyr Thr Thr Val Val 
    210                 215                 220                 

Val Ala Ser Ala Ser Glu Pro Ala Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Cys Ala Met Ala Glu Tyr Tyr Leu Tyr Asn Gly Gln His Ala 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Asn Asp Glu His Gly Gly Gly Ser Leu Thr Ala Leu Pro Phe Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Glu Ser Asp Leu Phe Phe Ala Gly 
            340                 345                 350         

Val Arg Pro Ala Ile Asn Val Gly Ser Ser Val Ser Arg Val Gly Ser 
        355                 360                 365             

Ala Ala Gln Thr Lys Ala Met Lys Lys Val Ala Gly Thr Leu Lys Leu 
    370                 375                 380                 

Asp Leu Ala Gln Tyr Arg Glu Leu Gln Ala Phe Thr Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Asp Thr Leu Arg Arg Gly Glu Arg Met 
                405                 410                 415     

Thr Glu Leu Leu Lys Gln Pro Gln Tyr His Pro Leu Thr Phe Asp Arg 
            420                 425                 430         

Gln Val Ala Ser Leu Trp Thr Gly Val Asn Gly Tyr Leu Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Ala Val Gln Lys Phe Glu Arg Glu Trp Leu Ala Phe Leu 
    450                 455                 460                 

Asp Arg Glu Tyr Pro Gln Val Phe Gln Asn Met Gln Glu Arg Lys Ser 
465                 470                 475                 480 

Leu Glu Asp Asp Thr Ile Glu Leu Met Lys Glu Ala Met Ala Lys Phe 
                485                 490                 495     

Lys Pro Thr Phe Val Pro 
            500         

<210>   1302
<211>   502
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1293

<400>   1302
Met Ser Ile Arg Pro Asp Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Gln Phe Glu Val Lys Ala Glu Val Arg Asp Thr Gly Thr Val Leu 
            20                  25                  30          

Ser Val Gly Asp Gly Ile Ala Arg Leu Tyr Gly Leu Asp Asn Val Met 
        35                  40                  45              

Ala Gly Glu Leu Val Glu Phe Glu Ser Gly Val Tyr Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asp Asn Val Gly Val Val Val Leu Gly Ser Val Gln 
65                  70                  75                  80  

Gly Ile Arg Glu Gly Asp Gln Val Arg Arg Thr Gly Arg Leu Val Thr 
                85                  90                  95      

Val Pro Val Gly Pro Gln Leu Leu Gly Arg Val Val Asn Ala Leu Gly 
            100                 105                 110         

Gln Pro Ile Asp Asn Lys Gly Pro Ile Glu Ala Thr Glu Tyr Arg Pro 
        115                 120                 125             

Val Glu Ser Pro Ala Pro Gly Val Ile Val Arg Arg Ser Val His Glu 
    130                 135                 140                 

Pro Leu Glu Thr Gly Ile Lys Ala Ile Asp Ser Met Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ala Ile Ala Leu Asp Thr Ile Ile Asn Gln Lys Gly Lys Asp Val Lys 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Gln Ser Thr Val Ala Gln Val 
        195                 200                 205             

Val Glu Thr Leu Arg Arg Tyr Gly Ala Met Glu Tyr Thr Thr Val Val 
    210                 215                 220                 

Val Ala Ser Ala Ser Glu Pro Ala Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Cys Ala Met Ala Glu Tyr Tyr Leu Tyr Asn Gly Gln His Ala 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Asn Asp Glu His Gly Gly Gly Ser Leu Thr Ala Leu Pro Phe Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Glu Ser Asp Leu Phe Phe Ala Gly 
            340                 345                 350         

Val Arg Pro Ala Ile Asn Val Gly Ser Ser Val Ser Arg Val Gly Ser 
        355                 360                 365             

Ala Ala Gln Thr Lys Ala Met Lys Lys Val Ala Gly Thr Leu Lys Leu 
    370                 375                 380                 

Asp Leu Ala Gln Tyr Arg Glu Leu Gln Ala Phe Thr Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Asp Thr Leu Arg Arg Gly Glu Arg Met 
                405                 410                 415     

Thr Glu Leu Leu Lys Gln Pro Gln Tyr His Pro Leu Thr Phe Asp Arg 
            420                 425                 430         

Gln Val Ala Ser Leu Trp Thr Gly Val Asn Gly Tyr Leu Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Ala Val Gln Lys Phe Glu Arg Glu Trp Leu Ala Phe Leu 
    450                 455                 460                 

Asp Arg Glu Tyr Pro Gln Val Phe Gln Gln Met Gln Glu Arg Lys Ser 
465                 470                 475                 480 

Leu Glu Asp Asp Thr Ile Glu Leu Met Lys Glu Ala Met Ala Lys Phe 
                485                 490                 495     

Lys Pro Thr Phe Val Pro 
            500         

<210>   1303
<211>   502
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1293

<400>   1303
Met Ser Ile Arg Pro Asp Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Gln Phe Glu Val Lys Ala Glu Val Arg Asp Thr Gly Thr Val Leu 
            20                  25                  30          

Ser Val Gly Asp Gly Ile Ala Arg Leu Tyr Gly Leu Asp Asn Val Met 
        35                  40                  45              

Ala Gly Glu Leu Val Glu Phe Glu Ser Gly Val Tyr Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asp Asn Val Gly Val Val Val Leu Gly Ser Val Gln 
65                  70                  75                  80  

Gly Ile Arg Glu Gly Glu Gln Val Arg Arg Thr Gly Arg Leu Val Thr 
                85                  90                  95      

Val Pro Val Gly Pro Gln Leu Leu Gly Arg Val Val Asn Ala Leu Gly 
            100                 105                 110         

Gln Pro Ile Asp Asn Lys Gly Pro Ile Glu Ala Thr Glu Tyr Arg Pro 
        115                 120                 125             

Val Glu Ser Pro Ala Pro Gly Val Ile Val Arg Arg Ser Val His Glu 
    130                 135                 140                 

Pro Leu Glu Thr Gly Ile Lys Ala Ile Asp Ser Met Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ala Ile Ala Leu Asp Thr Ile Ile Asn Gln Lys Gly Lys Asp Val Lys 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Gln Ser Thr Val Ala Gln Val 
        195                 200                 205             

Val Glu Thr Leu Arg Arg Tyr Gly Ala Met Glu Tyr Thr Thr Val Val 
    210                 215                 220                 

Val Ala Ser Ala Ser Glu Pro Ala Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Cys Ala Met Ala Glu Tyr Tyr Leu Tyr Asn Gly Gln His Ala 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Asn Asp Glu His Gly Gly Gly Ser Leu Thr Ala Leu Pro Phe Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Glu Ser Asp Leu Phe Phe Ala Gly 
            340                 345                 350         

Val Arg Pro Ala Ile Asn Val Gly Ser Ser Val Ser Arg Val Gly Ser 
        355                 360                 365             

Ala Ala Gln Thr Lys Ala Met Lys Lys Val Ala Gly Thr Leu Lys Leu 
    370                 375                 380                 

Asp Leu Ala Gln Tyr Arg Glu Leu Gln Ala Phe Thr Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Asp Thr Leu Arg Arg Gly Glu Arg Met 
                405                 410                 415     

Thr Glu Leu Leu Lys Gln Pro Gln Tyr His Pro Leu Thr Phe Asp Arg 
            420                 425                 430         

Gln Val Ala Ser Leu Trp Thr Gly Val Asn Gly Tyr Leu Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Ala Val Gln Lys Phe Glu Arg Glu Trp Leu Ala Phe Leu 
    450                 455                 460                 

Asp Arg Glu Tyr Pro Gln Val Phe Gln Gln Met Gln Glu Arg Lys Ser 
465                 470                 475                 480 

Leu Glu Asp Glu Thr Ile Glu Leu Met Lys Glu Ala Met Ala Lys Phe 
                485                 490                 495     

Lys Pro Thr Phe Val Pro 
            500         

<210>   1304
<211>   502
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1293

<400>   1304
Met Ser Ile Arg Pro Asp Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
                5                   10                  15      

Glu Gln Phe Glu Val Lys Ala Glu Val Arg Asp Thr Gly Thr Val Leu 
            20                  25                  30          

Ser Val Gly Asp Gly Ile Ala Arg Leu Tyr Gly Leu Asp Asn Val Met 
        35                  40                  45              

Ala Gly Glu Leu Val Glu Phe Glu Ser Gly Val Tyr Gly Met Ala Leu 
    50                  55                  60                  

Asn Leu Glu Glu Asp Asn Val Gly Val Val Val Leu Gly Ser Val Gln 
65                  70                  75                  80  

Gly Ile Arg Glu Gly Glu Gln Val Arg Arg Thr Gly Arg Leu Val Thr 
                85                  90                  95      

Val Pro Val Gly Pro Gln Leu Leu Gly Arg Val Val Asn Ala Leu Gly 
            100                 105                 110         

Gln Pro Ile Asp Asn Lys Gly Pro Ile Glu Ala Thr Glu Tyr Arg Pro 
        115                 120                 125             

Val Glu Ser Pro Ala Pro Gly Val Ile Val Arg Arg Ser Val His Glu 
    130                 135                 140                 

Pro Leu Glu Thr Gly Ile Lys Ala Ile Asp Ser Met Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Ala Ile Ala Leu Asp Thr Ile Ile Asn Gln Lys Gly Lys Asp Val Lys 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Gln Ser Thr Val Ala Asn Val 
        195                 200                 205             

Val Glu Thr Leu Arg Arg Tyr Gly Ala Met Glu Tyr Thr Thr Val Val 
    210                 215                 220                 

Val Ala Ser Ala Ser Glu Pro Ala Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Cys Ala Met Ala Glu Tyr Tyr Leu Tyr Asn Gly Gln His Ala 
                245                 250                 255     

Leu Val Val Tyr Asp Asp Leu Ser Lys Gln Ala Ala Ala Tyr Arg Glu 
            260                 265                 270         

Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Leu 
    290                 295                 300                 

Asn Asp Glu His Gly Gly Gly Ser Leu Thr Ala Leu Pro Phe Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Glu Ser Asp Leu Phe Phe Ala Gly 
            340                 345                 350         

Val Arg Pro Ala Ile Asn Val Gly Ser Ser Val Ser Arg Val Gly Ser 
        355                 360                 365             

Ala Ala Gln Thr Lys Ala Met Lys Lys Val Ala Gly Thr Leu Lys Leu 
    370                 375                 380                 

Asp Leu Ala Gln Tyr Arg Glu Leu Gln Ala Phe Thr Gln Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Lys Ala Thr Gln Asp Thr Leu Arg Arg Gly Glu Arg Met 
                405                 410                 415     

Thr Glu Leu Leu Lys Gln Pro Gln Tyr His Pro Leu Thr Phe Asp Arg 
            420                 425                 430         

Gln Val Ala Ser Leu Trp Thr Gly Val Asn Gly Tyr Leu Asp Asp Ile 
        435                 440                 445             

Pro Val Glu Ala Val Gln Lys Phe Glu Arg Glu Trp Leu Ala Phe Leu 
    450                 455                 460                 

Asp Arg Glu Tyr Pro Gln Val Phe Gln Gln Met Gln Glu Arg Lys Ser 
465                 470                 475                 480 

Leu Glu Asp Asp Thr Ile Glu Leu Met Lys Glu Ala Met Ala Lys Phe 
                485                 490                 495     

Lys Pro Thr Phe Val Pro 
            500         

<210>   1305
<211>   1509
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1294

<400>   1305
ttgagcattc gtccggatga aatcagcgcg ctcatcaagc aacagatcga gcagttcgag       60

gtcaaggccg aggtgcgcga cacgggcacg gtgctgtcgg tgggcgacgg cattgcgcgc      120

ctctatggct tggacaacgt catggcgggc gaactggtcg agttcgaaag cggcgtgtac      180

ggcatggcgc tgaacctgga ggaggacaac gtcggcgtcg tggtgctcgg gtccgtgaat      240

ggcatccgcg aaggcgaaca ggtgcgccgc accggacgct tggtcacggt gccggtgggt      300

ccgcagctct tggggcgcgt cgtgaacgcg ctgggtcaac ccattgacaa taagggcccc      360

attgaggcca cggagtatcg tcccgtcgag tcgccggcgc cgggcgtcat cgtgcgccgc      420

tctgtgcacg agccgctcga gacgggcatc aaggccatcg actcgatggt gcccatcgga      480

cgcggtcagc gcgagctgat catcggcgac cgccagacgg ggaaaacggc cattgcgctc      540

gacaccatca tcaaccaaaa gggcaaggac gtgaagtgca tctacgtcgc catcgggcag      600

aagcagtcca cggtggcgca agtcgtggag acgcttcgcc gctacggcgc gatggagtac      660

accaccgtgg tcgtggcgag cgcttcggag cccgctccgc tcctgttcct cgctccctac      720

gccgggtgcg cgatggcgga gtactacctg tacaacgggc agcacgcgct cgtggtgtac      780

gacgacctgt cgaagcaggc cgcggcatac cgcgagatgt cgctcttgct gcgccgcccg      840

ccgggccgcg aggcgtatcc gggagacgtg ttctatctgc attcgcgcct cttggagcgc      900

gccgcgaagc tgaacgacga gcacggcggc ggttcgctca cggccctgcc gttcattgag      960

acgcaggcgg gcgacatctc cgcgtacatc ccgaccaacg tcatctcgat cacggacggc     1020

cagatcttcc tcgagtcgga tctgttcttc gcgggcgtgc ggccggccat caacgtcgga     1080

tcgtcggtgt cccgcgtggg ctccgccgcg cagacgaagg ccatgaagaa ggtcgcgggc     1140

acgctgaagc tcgatctcgc ccagtaccgc gagctccagg ccttcaccca gttcggcagc     1200

gatctggaca aggcgacgca ggacaccctg cgccggggcg aacggatgac ggagctgttg     1260

aagcaaccgc agtatcaccc gctgacgttc gatcggcagg tcgcgtcgct ctggacgggc     1320

gtgaacggct atctggacga catcccggtc gaggccgtgc agaagttcga gcgcgagtgg     1380

ctcgccttct tggaccgcga gtatccgcag gtgttccaac agatgcagga gcgcaaatcg     1440

cttgaggacg ataccatcga gctcatgaaa gaagcgatgg cgaagttcaa gccgacgttt     1500

gtgccctga                                                             1509


<210>   1306
<211>   1509
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1294

<400>   1306
ttgagcattc gtccggatga aatcagcgcg ctcatcaagc aacagatcga gcagttcgag       60

gtcaaggccg aggtgcgcga cacgggcacg gtgctgtcgg tgggcgacgg cattgcgcgc      120

ctctatggct tggacaacgt catggcgggc gaactggtcg agttcgaaag cggcgtgtac      180

ggcatggcgc tgaacctgga ggaggacaac gtcggcgtcg tggtgctcgg gtccgtgcag      240

ggcatccgcg aaggcgaaca ggtgcgccgc accggacgct tggtcacggt gccggtgggt      300

ccgcagctct tggggcgcgt cgtgaacgcg ctgggtcaac ccattgacaa taagggcccc      360

attgaggcca cggagtatcg tcccgtcgag tcgccggcgc cgggcgtcat cgtgcgccgc      420

tctgtgcacg agccgctcga gacgggcatc aaggccatcg actcgatggt gcccatcgga      480

cgcggtcagc gcgagctgat catcggcgac cgccagacgg ggaaaacggc cattgcgctc      540

gacaccatca tcaaccaaaa gggcaaggac gtgaagtgca tctacgtcgc catcgggcag      600

aagcagtcca cggtggcgca agtcgtggag acgcttcgcc gctacggcgc gatggagtac      660

accaccgtgg tcgtggcgag cgcttcggag cccgctccgc tcctgttcct cgctccctac      720

gccgggtgcg cgatggcgga gtactacctg tacaacgggc agcacgcgct cgtggtgtac      780

gacgacctgt cgaagcaggc cgcggcatac cgcgagatgt cgctcttgct gcgccgcccg      840

ccgggccgcg aggcgtatcc gggagacgtg ttctatctgc attcgcgcct cttggagcgc      900

gccgcgaagc tgaacgacga gcacggcggc ggttcgctca cggccctgcc gttcattgag      960

acgcaggcgg gcgacatctc cgcgtacatc ccgaccaacg tcatctcgat cacggacggc     1020

cagatcttcc tcgagtcgga tctgttcttc gcgggcgtgc ggccggccat caacgtcgga     1080

tcgtcggtgt cccgcgtggg ctccgccgcg cagacgaagg ccatgaagaa ggtcgcgggc     1140

acgctgaagc tcgatctcgc ccagtaccgc gagctccagg ccttcaccca gttcggcagc     1200

gatctggaca aggcgacgca ggacaccctg cgccggggcg aacggatgac ggagctgttg     1260

aagcaaccgc agtatcaccc gctgacgttc gatcggcagg tcgcgtcgct ctggacgggc     1320

gtgaacggct atctggacga catcccggtc gaggccgtgc agaagttcga gcgcgagtgg     1380

ctcgccttct tggaccgcga gtatccgcag gtgttccaaa atatgcagga gcgcaaatcg     1440

cttgaggacg ataccatcga gctcatgaaa gaagcgatgg cgaagttcaa gccgacgttt     1500

gtgccctga                                                             1509


<210>   1307
<211>   1509
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1294

<400>   1307
ttgagcattc gtccggatga aatcagcgcg ctcatcaagc aacagatcga gcagttcgag       60

gtcaaggccg aggtgcgcga cacgggcacg gtgctgtcgg tgggcgacgg cattgcgcgc      120

ctctatggct tggacaacgt catggcgggc gaactggtcg agttcgaaag cggcgtgtac      180

ggcatggcgc tgaacctgga ggaggacaac gtcggcgtcg tggtgctcgg gtccgtgcag      240

ggcatccgcg aaggcgatca ggtgcgccgc accggacgct tggtcacggt gccggtgggt      300

ccgcagctct tggggcgcgt cgtgaacgcg ctgggtcaac ccattgacaa taagggcccc      360

attgaggcca cggagtatcg tcccgtcgag tcgccggcgc cgggcgtcat cgtgcgccgc      420

tctgtgcacg agccgctcga gacgggcatc aaggccatcg actcgatggt gcccatcgga      480

cgcggtcagc gcgagctgat catcggcgac cgccagacgg ggaaaacggc cattgcgctc      540

gacaccatca tcaaccaaaa gggcaaggac gtgaagtgca tctacgtcgc catcgggcag      600

aagcagtcca cggtggcgca agtcgtggag acgcttcgcc gctacggcgc gatggagtac      660

accaccgtgg tcgtggcgag cgcttcggag cccgctccgc tcctgttcct cgctccctac      720

gccgggtgcg cgatggcgga gtactacctg tacaacgggc agcacgcgct cgtggtgtac      780

gacgacctgt cgaagcaggc cgcggcatac cgcgagatgt cgctcttgct gcgccgcccg      840

ccgggccgcg aggcgtatcc gggagacgtg ttctatctgc attcgcgcct cttggagcgc      900

gccgcgaagc tgaacgacga gcacggcggc ggttcgctca cggccctgcc gttcattgag      960

acgcaggcgg gcgacatctc cgcgtacatc ccgaccaacg tcatctcgat cacggacggc     1020

cagatcttcc tcgagtcgga tctgttcttc gcgggcgtgc ggccggccat caacgtcgga     1080

tcgtcggtgt cccgcgtggg ctccgccgcg cagacgaagg ccatgaagaa ggtcgcgggc     1140

acgctgaagc tcgatctcgc ccagtaccgc gagctccagg ccttcaccca gttcggcagc     1200

gatctggaca aggcgacgca ggacaccctg cgccggggcg aacggatgac ggagctgttg     1260

aagcaaccgc agtatcaccc gctgacgttc gatcggcagg tcgcgtcgct ctggacgggc     1320

gtgaacggct atctggacga catcccggtc gaggccgtgc agaagttcga gcgcgagtgg     1380

ctcgccttct tggaccgcga gtatccgcag gtgttccaac agatgcagga gcgcaaatcg     1440

cttgaggacg ataccatcga gctcatgaaa gaagcgatgg cgaagttcaa gccgacgttt     1500

gtgccctga                                                             1509


<210>   1308
<211>   1509
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1294

<400>   1308
ttgagcattc gtccggatga aatcagcgcg ctcatcaagc aacagatcga gcagttcgag       60

gtcaaggccg aggtgcgcga cacgggcacg gtgctgtcgg tgggcgacgg cattgcgcgc      120

ctctatggct tggacaacgt catggcgggc gaactggtcg agttcgaaag cggcgtgtac      180

ggcatggcgc tgaacctgga ggaggacaac gtcggcgtcg tggtgctcgg gtccgtgcag      240

ggcatccgcg aaggcgaaca ggtgcgccgc accggacgct tggtcacggt gccggtgggt      300

ccgcagctct tggggcgcgt cgtgaacgcg ctgggtcaac ccattgacaa taagggcccc      360

attgaggcca cggagtatcg tcccgtcgag tcgccggcgc cgggcgtcat cgtgcgccgc      420

tctgtgcacg agccgctcga gacgggcatc aaggccatcg actcgatggt gcccatcgga      480

cgcggtcagc gcgagctgat catcggcgac cgccagacgg ggaaaacggc cattgcgctc      540

gacaccatca tcaaccaaaa gggcaaggac gtgaagtgca tctacgtcgc catcgggcag      600

aagcagtcca cggtggcgca agtcgtggag acgcttcgcc gctacggcgc gatggagtac      660

accaccgtgg tcgtggcgag cgcttcggag cccgctccgc tcctgttcct cgctccctac      720

gccgggtgcg cgatggcgga gtactacctg tacaacgggc agcacgcgct cgtggtgtac      780

gacgacctgt cgaagcaggc cgcggcatac cgcgagatgt cgctcttgct gcgccgcccg      840

ccgggccgcg aggcgtatcc gggagacgtg ttctatctgc attcgcgcct cttggagcgc      900

gccgcgaagc tgaacgacga gcacggcggc ggttcgctca cggccctgcc gttcattgag      960

acgcaggcgg gcgacatctc cgcgtacatc ccgaccaacg tcatctcgat cacggacggc     1020

cagatcttcc tcgagtcgga tctgttcttc gcgggcgtgc ggccggccat caacgtcgga     1080

tcgtcggtgt cccgcgtggg ctccgccgcg cagacgaagg ccatgaagaa ggtcgcgggc     1140

acgctgaagc tcgatctcgc ccagtaccgc gagctccagg ccttcaccca gttcggcagc     1200

gatctggaca aggcgacgca ggacaccctg cgccggggcg aacggatgac ggagctgttg     1260

aagcaaccgc agtatcaccc gctgacgttc gatcggcagg tcgcgtcgct ctggacgggc     1320

gtgaacggct atctggacga catcccggtc gaggccgtgc agaagttcga gcgcgagtgg     1380

ctcgccttct tggaccgcga gtatccgcag gtgttccaac agatgcagga gcgcaaatcg     1440

cttgaggacg aaaccatcga gctcatgaaa gaagcgatgg cgaagttcaa gccgacgttt     1500

gtgccctga                                                             1509


<210>   1309
<211>   1509
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1294

<400>   1309
ttgagcattc gtccggatga aatcagcgcg ctcatcaagc aacagatcga gcagttcgag       60

gtcaaggccg aggtgcgcga cacgggcacg gtgctgtcgg tgggcgacgg cattgcgcgc      120

ctctatggct tggacaacgt catggcgggc gaactggtcg agttcgaaag cggcgtgtac      180

ggcatggcgc tgaacctgga ggaggacaac gtcggcgtcg tggtgctcgg gtccgtgcag      240

ggcatccgcg aaggcgaaca ggtgcgccgc accggacgct tggtcacggt gccggtgggt      300

ccgcagctct tggggcgcgt cgtgaacgcg ctgggtcaac ccattgacaa taagggcccc      360

attgaggcca cggagtatcg tcccgtcgag tcgccggcgc cgggcgtcat cgtgcgccgc      420

tctgtgcacg agccgctcga gacgggcatc aaggccatcg actcgatggt gcccatcgga      480

cgcggtcagc gcgagctgat catcggcgac cgccagacgg ggaaaacggc cattgcgctc      540

gacaccatca tcaaccaaaa gggcaaggac gtgaagtgca tctacgtcgc catcgggcag      600

aagcagtcca cggtggcgaa tgtcgtggag acgcttcgcc gctacggcgc gatggagtac      660

accaccgtgg tcgtggcgag cgcttcggag cccgctccgc tcctgttcct cgctccctac      720

gccgggtgcg cgatggcgga gtactacctg tacaacgggc agcacgcgct cgtggtgtac      780

gacgacctgt cgaagcaggc cgcggcatac cgcgagatgt cgctcttgct gcgccgcccg      840

ccgggccgcg aggcgtatcc gggagacgtg ttctatctgc attcgcgcct cttggagcgc      900

gccgcgaagc tgaacgacga gcacggcggc ggttcgctca cggccctgcc gttcattgag      960

acgcaggcgg gcgacatctc cgcgtacatc ccgaccaacg tcatctcgat cacggacggc     1020

cagatcttcc tcgagtcgga tctgttcttc gcgggcgtgc ggccggccat caacgtcgga     1080

tcgtcggtgt cccgcgtggg ctccgccgcg cagacgaagg ccatgaagaa ggtcgcgggc     1140

acgctgaagc tcgatctcgc ccagtaccgc gagctccagg ccttcaccca gttcggcagc     1200

gatctggaca aggcgacgca ggacaccctg cgccggggcg aacggatgac ggagctgttg     1260

aagcaaccgc agtatcaccc gctgacgttc gatcggcagg tcgcgtcgct ctggacgggc     1320

gtgaacggct atctggacga catcccggtc gaggccgtgc agaagttcga gcgcgagtgg     1380

ctcgccttct tggaccgcga gtatccgcag gtgttccaac agatgcagga gcgcaaatcg     1440

cttgaggacg ataccatcga gctcatgaaa gaagcgatgg cgaagttcaa gccgacgttt     1500

gtgccctga                                                             1509


<210>   1310
<211>   365
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1310
Met Thr Asp Met Gly Lys Pro Thr Ile Ile Val Met Glu Gly Asp Gln 
                5                   10                  15      

Thr Gly Gln Glu Leu Leu Glu Glu Ala Leu Arg Val Leu Ser Pro Asp 
            20                  25                  30          

Val Thr Gly Tyr Glu Ile Glu Ile Arg Lys Phe Asp Leu Ser Leu Glu 
        35                  40                  45              

Asn Arg Arg Arg Thr Gln Asn Ala Val Val His Glu Ala Ala Glu Ala 
    50                  55                  60                  

Met Arg Asp Thr Gly Leu Gly Leu Lys Ala Ala Thr Ile Thr Pro Glu 
65                  70                  75                  80  

Glu Lys Gly Asp Val Gly Ser Pro Asn Ala Ile Leu Arg Lys Glu Ile 
                85                  90                  95      

Asn Gly Thr Val Ile Val Arg Thr Gly Arg Arg Ile Pro Gly Ile Ala 
            100                 105                 110         

Pro Pro Val Gly Val Tyr Ser Pro Ile Ser Val Ile Arg Met Ala Val 
        115                 120                 125             

Asp Asp Ala Tyr Gly Ala Lys Glu Trp Arg Glu Gln Leu Glu Asn Gly 
    130                 135                 140                 

Asp Glu Val Ala Tyr Arg Thr Glu Lys Ile Ser Arg Ser Val Cys Arg 
145                 150                 155                 160 

Gly Val Ala Lys Tyr Ala Phe Gln His Ala Arg Arg Met His Ala Lys 
                165                 170                 175     

Val Phe Gly Gly Pro Lys Tyr Thr Val Ser Pro Val Tyr Glu Gly Met 
            180                 185                 190         

Leu Lys Glu Glu Met Asp Ala Ala Ala Lys Glu Tyr Pro Asp Val Arg 
        195                 200                 205             

Tyr Glu Pro Gln Leu Ile Asp Ala Thr Tyr Ala Leu Leu Leu Ala Arg 
    210                 215                 220                 

Ala Gly Glu Ala Leu Val Ile Pro Ala Leu Asn Arg Asp Gly Asp Cys 
225                 230                 235                 240 

Leu Ser Asp Leu Val Leu Gln Met Phe Gly Thr Ile Ala Gly Ser Glu 
                245                 250                 255     

Ser Leu Leu Leu Ser Leu Asp Glu Ser Phe Gln Pro Lys Val Val Met 
            260                 265                 270         

Ala Glu Ala Pro His Gly Thr Ala Pro Asn Leu Phe Arg Lys Asn Met 
        275                 280                 285             

Ala Asn Pro Met Ala Met Ile Leu Ala Gly Ala Ala Leu Leu Asn Tyr 
    290                 295                 300                 

Ile Gln Asp Lys Asp Ala His Thr Val Ser Arg Ala Ile Tyr Glu Ala 
305                 310                 315                 320 

Thr Leu Glu Ser Ile Val Asp Gly Ile Arg Thr Ala Asp Leu Gly Gly 
                325                 330                 335     

His Ala Thr Thr Thr Glu Phe Thr Asp Glu Val Ile Arg Arg Val Arg 
            340                 345                 350         

Thr Lys Leu Glu Val Trp Ser Thr Phe Gly Asp Ala Val 
        355                 360                 365 

<210>   1311
<211>   1098
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1311
gtgacggaca tggggaaacc gaccatcatc gtgatggagg gtgatcagac gggacaggag       60

cttctggagg aagcgctccg cgtgctgtcg cccgatgtca cggggtacga gattgagatt      120

cgcaagtttg atctgagcct cgaaaatcgc cggcgcacgc aaaatgccgt ggtgcacgag      180

gccgcagaag ccatgcggga cacgggcctc gggctcaagg ccgcgaccat cacgccggaa      240

gaaaagggcg acgtgggtag cccgaacgcc atcctgcgca aggaaatcaa cggcacggtg      300

attgtccgca ctggacgccg tatcccgggg atcgcgccgc cggtgggcgt ctactcgccc      360

atttcggtca tccgcatggc ggtggacgac gcctacggag ccaaggaatg gcgcgaacaa      420

ctggaaaacg gcgacgaggt ggcgtaccgc acggagaaaa tttcgcgatc cgtctgccgg      480

ggcgtggcca agtacgcgtt ccagcacgcg cgccgcatgc acgcgaaggt gtttggcggg      540

cccaaataca ccgtgagccc tgtgtacgaa ggcatgctga aggaagaaat ggacgccgcg      600

gccaaggaat atcccgacgt gcgctacgag ccgcagctca tcgacgcgac gtatgcgctc      660

ctcctggcgc gcgcgggtga agcactcgtc atcccggcgc tgaaccgcga cggcgactgc      720

ttgtccgatc tcgtcctcca gatgttcggc accatcgccg gatcagaatc actgcttctg      780

tcgctcgacg agtcgttcca gcccaaggtc gtgatggccg aagcgcctca tgggacggcg      840

cccaatctct tcaggaaaaa catggccaac ccgatggcca tgatcctggc cggcgccgcc      900

ctgttgaact acatccaaga caaggacgcc cacacggtat cgcgggccat ctacgaggcc      960

acgctcgagt ccattgtcga tgggattcgc acggccgatc tcggcggcca cgcgacgacc     1020

accgagttca cggacgaagt cattcggagg gttcggacga aactcgaggt ctggagcacg     1080

ttcggcgacg ccgtttga                                                   1098


<210>   1312
<211>   359
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   1312
Met Ser Lys Pro Thr Ile Val Val Leu Glu Gly Asp Gln Thr Gly Gln 
                5                   10                  15      

Glu Leu Leu Glu Glu Ser Leu Arg Val Leu Asp Pro Ala Val Thr Gly 
            20                  25                  30          

Val Asp Ile Glu Leu Lys Arg Tyr Asp Leu Ser Leu Glu Ser Arg Arg 
        35                  40                  45              

Ala Thr Asn Asn Gln Ile Val Leu Glu Ala Ala Gln Ala Met Lys Glu 
    50                  55                  60                  

Ala Gly Phe Gly Leu Lys Ala Ala Thr Ile Thr Pro Glu Lys Ala Gly 
65                  70                  75                  80  

Asp Val Gly Ser Pro Asn Ala Ile Leu Arg Glu Gln Ile Asn Gly Thr 
                85                  90                  95      

Val Ile Val Arg Thr Gly Arg Arg Ile Pro Gly Val Arg Pro Val Gly 
            100                 105                 110         

Gly Ala Tyr Ala Pro Ile Ser Val Ile Arg Met Ala Val Asp Asp Ala 
        115                 120                 125             

Tyr Gly Ala Lys Glu Trp Arg Glu Gly Glu Gly Asp Asn Glu Val Ala 
    130                 135                 140                 

Tyr Arg Thr Glu Lys Ile Thr Arg Gly Thr Cys Arg Ala Val Ser Glu 
145                 150                 155                 160 

Tyr Ala Phe Met His Ala Arg Arg Met Lys Ala Lys Val Phe Gly Gly 
                165                 170                 175     

Pro Lys Tyr Thr Val Ser Pro Ile Tyr Glu Gly Met Leu Lys Glu Glu 
            180                 185                 190         

Met Asp Ala Ala Ala Lys Arg Tyr Ala Asp Val Arg Tyr Glu Pro Gln 
        195                 200                 205             

Leu Ile Asp Ala Thr Tyr Ala Leu Leu Leu Thr Asn Ser Gly Asp Pro 
    210                 215                 220                 

Met Val Ile Pro Ala Leu Asn Arg Asp Gly Asp Cys Leu Ser Asp Leu 
225                 230                 235                 240 

Val Leu Gln Met Phe Gly Thr Ile Ala Gly Ala Glu Ser Leu Leu Leu 
                245                 250                 255     

Ala Phe Asp Lys Asp Phe Lys Val Asn Val Val Met Ala Glu Ala Pro 
            260                 265                 270         

His Gly Thr Ala Pro Ser Leu Glu Gly Lys Asn Val Ala Asn Pro Met 
        275                 280                 285             

Ala Met Ile Leu Ala Ser Ala Ala Leu Leu Asp Tyr Ile Asp Thr Pro 
    290                 295                 300                 

Gln Ala Asn Met Ala Ala Arg Ala Ile Ser Glu Ala Thr Leu Glu Ala 
305                 310                 315                 320 

Val Tyr Asp Gly Val Arg Thr Ala Asp Leu Gly Gly His Thr Thr Thr 
                325                 330                 335     

Ser Asp Phe Thr Asp Glu Val Ile Arg Arg Val Lys Thr Lys Met Glu 
            340                 345                 350         

Val Trp Pro Ser Leu Gly Asn 
        355                 

<210>   1313
<211>   355
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   1313
Met Glu Ser Arg Thr Ile Ala Val Leu Glu Gly Asp Gln Thr Gly Gln 
                5                   10                  15      

Glu Leu Leu Glu Glu Ala Leu Arg Val Leu Asp Pro Gly Val Thr Gly 
            20                  25                  30          

Leu Glu Leu Glu Phe Arg Arg Phe Asp Leu Ser Leu Glu Asn Arg Arg 
        35                  40                  45              

Arg Thr Glu Asn Arg Val Val His Glu Ala Ala Ala Ala Met Arg Glu 
    50                  55                  60                  

Cys Gly Tyr Gly Ile Lys Ala Ala Thr Ile Thr Pro Glu Arg Ala Gly 
65                  70                  75                  80  

Asp Val Gly Ser Pro Asn Ala Leu Leu Arg Lys Asp Ile Asn Gly Thr 
                85                  90                  95      

Val Ile Val Arg Thr Gly Arg Arg Ile Pro Gly Val Asn Pro Leu Pro 
            100                 105                 110         

Gly Val His Ala Pro Ile Ser Val Val Arg Met Ala Val Asp Asp Ala 
        115                 120                 125             

Tyr Gly Ala Glu Glu Trp Arg Glu Gly Glu Gly Pro Asp Glu Val Ala 
    130                 135                 140                 

Tyr Arg Thr Glu Lys Ile Ser Arg Arg Val Cys Arg Gly Val Ala Glu 
145                 150                 155                 160 

Phe Ala Phe Ile His Ala Arg Arg Met Arg Ala Lys Val Phe Gly Gly 
                165                 170                 175     

Pro Lys Trp Thr Val Ser Pro Val Tyr Glu Gly Met Leu Lys Glu Glu 
            180                 185                 190         

Met Asp Arg Ala Ala Glu Lys Asn Pro Asp Val Arg Tyr Glu Pro Gln 
        195                 200                 205             

Leu Ile Asp Ala Thr Tyr Ala Leu Leu Leu Ser Thr Tyr Gly Glu Pro 
    210                 215                 220                 

Leu Val Ile Pro Thr Leu Asn Arg Asp Gly Asp Cys Leu Ser Asp Met 
225                 230                 235                 240 

Val Leu Gln Met Phe Gly Ser Ile Ala Gly Ala Glu Ser Leu Leu Ile 
                245                 250                 255     

Ala Leu Asp Glu Glu Glu Arg Pro Gln Thr Val Met Ala Glu Ala Pro 
            260                 265                 270         

His Gly Thr Ala Pro Ser Leu Glu Gly Lys Asn Ile Ala Asn Pro Met 
        275                 280                 285             

Ala Met Ile Leu Ala Gly Ala Ala Leu Leu Gly Phe Phe Glu Asp Glu 
    290                 295                 300                 

Gln Ala Gly Arg Val Ser Arg Ala Ile Tyr Glu Ser Thr Phe Glu Thr 
305                 310                 315                 320 

Val Leu Asp Gly Val Lys Thr Ala Asp Leu Gly Gly Ser Ala Thr Thr 
                325                 330                 335     

Thr Glu Phe Thr Asp Glu Val Ile Arg His Val Arg Asn Lys Leu Glu 
            340                 345                 350         

Val Trp Ser 
        355 

<210>   1314
<211>   355
<212>   PRT
<213>   Pelobacter carbinolicus DSM 2380

<400>   1314
Pro Thr Ile Thr Val Leu Glu Gly Asp Gln Thr Gly Gln Glu Leu Leu 
                5                   10                  15      

Glu Glu Ala Leu Arg Ile Leu Asp Pro Ala Val Thr Gly Val Thr Val 
            20                  25                  30          

Thr Phe Lys His Phe Asp Leu Ser Leu Asp Asn Arg Arg Ala Thr Lys 
        35                  40                  45              

Asn Lys Val Val Tyr Glu Ala Ala Glu Ser Met Lys Ser Thr Gly Leu 
    50                  55                  60                  

Gly Leu Lys Ala Ala Thr Ile Thr Pro Ala Ile Lys Gly Asp Val Gly 
65                  70                  75                  80  

Ser Pro Asn Ala Ile Leu Arg Asp Gln Val Asp Gly Thr Val Ile Val 
                85                  90                  95      

Arg Thr Gly Arg Arg Ile Pro Gly Ile Arg Pro Ser Gly Gly Ala Tyr 
            100                 105                 110         

Ala Pro Ile Ser Val Val Arg Met Ala Val Gly Gly Ser Tyr Gly Ala 
        115                 120                 125             

Gln Glu Ser Arg Gln Gly Thr Gly Leu Asp Glu Val Ala Ser Arg Thr 
    130                 135                 140                 

Glu Ser Ile Thr Arg Arg Asn Cys His Ala Val Ala Glu Phe Ala Phe 
145                 150                 155                 160 

Arg His Ala Gln Lys Leu Gly Val Lys Val Phe Gly Gly Pro Lys Phe 
                165                 170                 175     

Thr Val Ser Pro Val Tyr Glu Gly Met Leu Lys Glu Glu Met Asp Ala 
            180                 185                 190         

Ala Ala Glu Arg Phe Pro Asp Val Val Tyr Glu Pro Gln Leu Ile Asp 
        195                 200                 205             

Ala Thr Tyr Ala Leu Leu Leu Thr Asn Gly Gly Asp Gly Met Val Ile 
    210                 215                 220                 

Pro Ser Leu Asn Arg Asp Gly Asp Cys Leu Ser Asp Phe Val Leu Gln 
225                 230                 235                 240 

Met Phe Gly Ser Ile Ala Gly Ala Glu Ser Leu Leu Leu Ser Phe Asp 
                245                 250                 255     

Glu Ser Trp Thr Pro Ala Val Val Met Ala Glu Ala Pro His Gly Thr 
            260                 265                 270         

Ala Pro Ser Leu Gln Gly Lys Asn Ile Ala Asn Pro Met Ala Met Ile 
        275                 280                 285             

Leu Ala Gly Gly Ala Leu Leu Arg Tyr Ile Asn His Pro Asp Ala Arg 
    290                 295                 300                 

Arg Ala Ala Arg Ala Ile Ser Glu Ser Val Phe Glu Ala Val Gln Gln 
305                 310                 315                 320 

Gly Phe Ser Thr Pro Asp Leu Gly Gly Ser Cys Thr Thr Thr Glu Phe 
                325                 330                 335     

Thr Asp Glu Val Ile Arg Arg Val Ala Ser Lys Leu Glu Val Trp Gln 
            340                 345                 350         

Thr Leu Gly 
        355 

<210>   1315
<211>   357
<212>   PRT
<213>   Microcystis aeruginosa PCC 7806

<400>   1315
Pro Thr Ile Val Val Met His Gly Asp Gln Thr Gly Glu Glu Leu Leu 
                5                   10                  15      

Leu Glu Ala Leu Arg Val Leu Gln Pro Ser Ile Ile Arg Gln Pro Leu 
            20                  25                  30          

Asn Phe Ala Asp Val Asp Leu Ser Leu Ala Gln Arg Arg Gln Ser Asn 
        35                  40                  45              

Asn Gln Val Val His Glu Ala Ala Glu Ala Thr Leu Lys Thr Gly Leu 
    50                  55                  60                  

Ala Leu Lys Ala Ala Thr Ile Thr Pro Glu Ile Lys Gly Asp Val Gly 
65                  70                  75                  80  

Ser Pro Asn Ala Ile Leu Arg Glu Ala Met Asn Ser Gln Val Ile Leu 
                85                  90                  95      

Arg Ile Gly Arg Arg Ile Pro Gly Ile Arg Pro Ile Gly Gly Val Tyr 
            100                 105                 110         

Ser Pro Ile Ala Ile Val Arg Met Ala Val Asp Asp Ala Tyr Gly Ala 
        115                 120                 125             

Lys Glu Trp Arg Glu Thr Thr Ala Thr Gly Asp Glu Ile Ala Tyr Arg 
    130                 135                 140                 

Thr Ser Arg Ile Ser Arg Ala Thr Ser Arg Ala Val Ala Glu Phe Thr 
145                 150                 155                 160 

Phe Gln His Ala Lys Lys Thr Gly Ala Arg Val Phe Gly Gly Pro Lys 
                165                 170                 175     

Phe Thr Val Ser Ala Thr Tyr Glu Gly Met Phe Lys Glu Glu Leu Asp 
            180                 185                 190         

Ala Ala Ala Gln Arg His Pro Glu Val Arg Tyr Gln Pro Leu Leu Ile 
        195                 200                 205             

Asp Ala Thr Phe Ala Leu Leu Leu Gln Thr Asp Gly Glu Ala Leu Val 
    210                 215                 220                 

Ile Pro Ala Leu Asn Arg Asp Gly Asp Leu Leu Ser Asp Phe Val Leu 
225                 230                 235                 240 

Gln Leu Tyr Gly Ser Ile Ala Gly Ala Glu Ser Leu Val Leu Gly Phe 
                245                 250                 255     

Asp Glu Glu Thr Leu Ala Val Lys Thr Ile Met Ala Glu Ala Pro His 
            260                 265                 270         

Gly Thr Ala Pro Ala Leu Glu Gly Lys Asn Ile Ala Asn Pro Met Ala 
        275                 280                 285             

Met Ile Leu Ala Ser Ala Ala Leu Leu Gly Tyr Ile Glu Thr Ser Glu 
    290                 295                 300                 

Ala Arg Lys Ala Ser Arg Ala Ile Tyr Glu Ser Val Phe Glu Thr Ile 
305                 310                 315                 320 

His Glu Gly Lys Lys Thr Pro Asp Leu Gly Gly Gln Met Thr Met Ser 
                325                 330                 335     

Glu Phe Thr Asp Glu Val Ile Arg Arg Val Val Ser Lys Leu Glu Val 
            340                 345                 350         

Trp Ser Ala Leu Gly 
        355         

<210>   1316
<211>   357
<212>   PRT
<213>   Microcystis aeruginosa NIES-843

<400>   1316
Pro Thr Ile Val Val Met His Gly Asp Gln Thr Gly Glu Glu Leu Leu 
                5                   10                  15      

Leu Glu Ala Leu Arg Val Leu Gln Pro Ser Ile Ile Arg Gln Pro Leu 
            20                  25                  30          

Asn Phe Ala Asp Phe Asp Leu Ser Leu Ala Gln Arg Arg Gln Ser Asn 
        35                  40                  45              

Asn Gln Val Val His Glu Ala Ala Glu Ala Thr Leu Lys Thr Gly Leu 
    50                  55                  60                  

Ala Leu Lys Ala Ala Thr Ile Thr Pro Glu Ile Lys Gly Asp Val Gly 
65                  70                  75                  80  

Ser Pro Asn Ala Ile Leu Arg Glu Ala Met Asn Ser Gln Val Ile Leu 
                85                  90                  95      

Arg Ile Gly Arg Arg Ile Pro Gly Ile Arg Pro Ile Gly Gly Val Tyr 
            100                 105                 110         

Ser Pro Ile Ala Ile Val Arg Met Ala Val Asp Asp Ala Tyr Gly Ala 
        115                 120                 125             

Lys Glu Trp Arg Glu Thr Thr Ala Thr Gly Asp Glu Ile Ala Tyr Arg 
    130                 135                 140                 

Thr Ser Arg Ile Ser Arg Ala Thr Ser Arg Ala Val Ala Glu Phe Thr 
145                 150                 155                 160 

Phe Gln Gln Ala Lys Lys Thr Gly Ala Arg Val Phe Gly Gly Pro Lys 
                165                 170                 175     

Phe Thr Val Ser Ala Thr Tyr Glu Gly Met Phe Lys Glu Glu Leu Asp 
            180                 185                 190         

Ala Ala Ala Gln Arg His Pro Glu Val Arg Tyr Gln Pro Leu Leu Ile 
        195                 200                 205             

Asp Ala Thr Phe Ala Leu Leu Leu Gln Thr Asp Gly Glu Ala Leu Val 
    210                 215                 220                 

Ile Pro Ala Leu Asn Arg Asp Gly Asp Leu Leu Ser Asp Phe Val Leu 
225                 230                 235                 240 

Gln Leu Tyr Gly Ser Ile Ala Gly Ala Glu Ser Leu Val Leu Gly Phe 
                245                 250                 255     

Asp Glu Glu Thr Leu Ala Val Lys Thr Ile Met Ala Glu Ala Pro His 
            260                 265                 270         

Gly Thr Ala Pro Ala Leu Glu Gly Lys Asn Ile Ala Asn Pro Met Ala 
        275                 280                 285             

Met Ile Leu Ala Ala Ala Ala Leu Leu Gly Tyr Ile Glu Thr Asn Glu 
    290                 295                 300                 

Ala Arg Lys Ala Ser Arg Ala Ile Tyr Glu Ser Val Phe Glu Thr Ile 
305                 310                 315                 320 

His Glu Gly Lys Lys Thr Pro Asp Leu Gly Gly Gln Met Thr Met Ser 
                325                 330                 335     

Glu Phe Thr Asp Glu Val Ile Arg Arg Val Val Ser Lys Leu Glu Val 
            340                 345                 350         

Trp Ser Ala Leu Gly 
        355         

<210>   1317
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1310

<400>   1317
Met Thr Asp Met Gly Lys Pro Thr Ile Leu Val Met Glu Gly Asp Gln 
                5                   10                  15      

Thr Gly Gln Glu Leu Leu Glu Glu Ala Leu Arg Val Leu Ser Pro Asp 
            20                  25                  30          

Val Thr Gly Tyr Glu Ile Glu Ile Arg Lys Phe Asp Leu Ser Leu Glu 
        35                  40                  45              

Asn Arg Arg Arg Thr Gln Asn Ala Val Val His Glu Ala Ala Glu Ala 
    50                  55                  60                  

Met Arg Asp Thr Gly Leu Gly Leu Lys Ala Ala Thr Ile Thr Pro Glu 
65                  70                  75                  80  

Glu Lys Gly Asp Val Gly Ser Pro Asn Ala Ile Leu Arg Lys Glu Ile 
                85                  90                  95      

Asn Gly Thr Val Ile Val Arg Thr Gly Arg Arg Ile Pro Gly Ile Ala 
            100                 105                 110         

Pro Pro Val Gly Val Tyr Ser Pro Ile Ser Val Ile Arg Met Ala Val 
        115                 120                 125             

Asp Asp Ala Tyr Gly Ala Lys Glu Trp Arg Glu Gln Leu Glu Asn Gly 
    130                 135                 140                 

Asp Glu Val Ala Tyr Arg Thr Glu Lys Ile Ser Arg Ser Val Cys Arg 
145                 150                 155                 160 

Gly Val Ala Lys Tyr Ala Phe Gln His Ala Arg Arg Met His Ala Lys 
                165                 170                 175     

Val Phe Gly Gly Pro Lys Tyr Thr Val Ser Pro Val Tyr Glu Gly Met 
            180                 185                 190         

Leu Lys Glu Glu Met Asp Ala Ala Ala Lys Glu Tyr Pro Asp Val Arg 
        195                 200                 205             

Tyr Glu Pro Gln Leu Ile Asp Ala Thr Tyr Ala Leu Leu Leu Ala Arg 
    210                 215                 220                 

Ala Gly Glu Ala Leu Val Ile Pro Ala Leu Asn Arg Asp Gly Asp Cys 
225                 230                 235                 240 

Leu Ser Asp Leu Val Leu Gln Met Phe Gly Thr Ile Ala Gly Ser Glu 
                245                 250                 255     

Ser Leu Leu Leu Ser Leu Asp Glu Ser Phe Gln Pro Lys Val Val Met 
            260                 265                 270         

Ala Glu Ala Pro His Gly Thr Ala Pro Asn Leu Phe Arg Lys Asn Met 
        275                 280                 285             

Ala Asn Pro Met Ala Met Ile Leu Ala Gly Ala Ala Leu Leu Asn Tyr 
    290                 295                 300                 

Ile Gln Asp Lys Asp Ala His Thr Val Ser Arg Ala Ile Tyr Glu Ala 
305                 310                 315                 320 

Thr Leu Glu Ser Ile Val Asp Gly Ile Arg Thr Ala Asp Leu Gly Gly 
                325                 330                 335     

His Ala Thr Thr Thr Glu Phe Thr Asp Glu Val Ile Arg Arg Val Arg 
            340                 345                 350         

Thr Lys Leu Glu Val Trp Ser Thr Phe Gly Asp Ala Val 
        355                 360                 365 

<210>   1318
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1310

<400>   1318
Met Thr Asp Met Gly Lys Pro Thr Ile Ile Val Met Glu Gly Asp Gln 
                5                   10                  15      

Thr Gly Gln Glu Leu Leu Glu Glu Ala Leu Arg Val Leu Ser Pro Asp 
            20                  25                  30          

Val Thr Gly Tyr Glu Ile Glu Ile Arg Lys Phe Asp Leu Ser Leu Glu 
        35                  40                  45              

Asn Arg Arg Arg Thr Gln Asn Ala Val Val His Glu Ala Ala Glu Ala 
    50                  55                  60                  

Met Arg Asp Thr Gly Leu Gly Leu Lys Ala Ala Thr Ile Thr Pro Glu 
65                  70                  75                  80  

Glu Lys Gly Asp Val Gly Ser Pro Asn Ala Ile Leu Arg Lys Glu Ile 
                85                  90                  95      

Asn Gly Thr Val Ile Val Arg Thr Gly Arg Arg Ile Pro Gly Ile Ala 
            100                 105                 110         

Pro Pro Val Gly Val Tyr Ser Pro Ile Ser Val Ile Arg Met Ala Val 
        115                 120                 125             

Asp Asp Ala Tyr Gly Ala Lys Glu Trp Arg Glu Gln Leu Glu Asn Gly 
    130                 135                 140                 

Asp Glu Val Ala Tyr Arg Thr Glu Lys Ile Ser Arg Ser Val Cys Arg 
145                 150                 155                 160 

Gly Val Ala Lys Tyr Ala Phe Gln His Ala Arg Arg Met His Ala Lys 
                165                 170                 175     

Val Phe Gly Gly Pro Lys Tyr Thr Val Ser Pro Val Tyr Glu Gly Met 
            180                 185                 190         

Leu Lys Glu Glu Met Asp Ala Ala Ala Lys Glu Tyr Pro Asp Val Arg 
        195                 200                 205             

Tyr Glu Pro Gln Leu Ile Asp Ala Thr Tyr Ala Leu Leu Leu Ala Arg 
    210                 215                 220                 

Ala Gly Glu Ala Leu Val Ile Pro Ala Leu Asn Arg Asp Gly Asp Cys 
225                 230                 235                 240 

Leu Ser Asp Leu Val Leu Gln Met Phe Gly Thr Ile Ala Gly Ser Glu 
                245                 250                 255     

Ser Leu Leu Leu Ser Leu Asp Glu Ser Phe Gln Pro Lys Val Val Met 
            260                 265                 270         

Ala Glu Ala Pro His Gly Thr Ala Pro Asn Leu Phe Lys Lys Asn Met 
        275                 280                 285             

Ala Asn Pro Met Ala Met Ile Leu Ala Gly Ala Ala Leu Leu Asn Tyr 
    290                 295                 300                 

Ile Gln Asp Lys Asp Ala His Thr Val Ser Arg Ala Ile Tyr Glu Ala 
305                 310                 315                 320 

Thr Leu Glu Ser Ile Val Asp Gly Ile Arg Thr Ala Asp Leu Gly Gly 
                325                 330                 335     

His Ala Thr Thr Thr Glu Phe Thr Asp Glu Val Ile Arg Arg Val Arg 
            340                 345                 350         

Thr Lys Leu Glu Val Trp Ser Thr Phe Gly Asp Ala Val 
        355                 360                 365 

<210>   1319
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1310

<400>   1319
Met Thr Asp Met Gly Lys Pro Thr Ile Ile Val Met Glu Gly Asp Gln 
                5                   10                  15      

Thr Gly Gln Glu Leu Leu Glu Glu Ala Leu Arg Val Leu Ser Pro Asp 
            20                  25                  30          

Val Thr Gly Tyr Glu Ile Glu Ile Arg Lys Phe Asp Leu Ser Leu Glu 
        35                  40                  45              

Asn Arg Arg Arg Thr Gln Asn Ala Val Val His Glu Ala Ala Glu Ala 
    50                  55                  60                  

Met Arg Asp Thr Gly Leu Gly Leu Lys Ala Ala Thr Ile Thr Pro Glu 
65                  70                  75                  80  

Glu Lys Gly Asp Val Gly Ser Pro Asn Ala Ile Leu Arg Lys Glu Ile 
                85                  90                  95      

Asn Gly Thr Val Ile Val Arg Thr Gly Arg Arg Ile Pro Gly Ile Ala 
            100                 105                 110         

Pro Pro Val Gly Val Tyr Ser Pro Ile Ser Val Ile Arg Met Ala Val 
        115                 120                 125             

Asp Asp Ala Tyr Gly Ala Lys Glu Trp Arg Glu Gln Leu Glu Asn Gly 
    130                 135                 140                 

Asp Glu Val Ala Tyr Arg Thr Glu Lys Ile Ser Arg Ser Val Cys Arg 
145                 150                 155                 160 

Gly Val Ala Lys Tyr Ala Phe Gln His Ala Arg Arg Met His Ala Lys 
                165                 170                 175     

Val Phe Gly Gly Pro Lys Tyr Thr Val Ser Pro Val Tyr Glu Gly Met 
            180                 185                 190         

Leu Lys Glu Glu Met Asp Ala Ala Ala Lys Glu Tyr Pro Asp Val Arg 
        195                 200                 205             

Tyr Glu Pro Gln Leu Ile Asp Ala Thr Tyr Ala Leu Leu Leu Ala Arg 
    210                 215                 220                 

Ala Gly Glu Ala Leu Val Ile Pro Ala Leu Asn Arg Asp Gly Asp Cys 
225                 230                 235                 240 

Leu Ser Asp Leu Val Leu Gln Met Phe Gly Thr Ile Ala Gly Ser Glu 
                245                 250                 255     

Ser Leu Leu Leu Ser Leu Asp Glu Ser Phe Gln Pro Lys Val Val Met 
            260                 265                 270         

Ala Glu Ala Pro His Gly Thr Ala Pro Asn Leu Phe Arg Lys Asn Met 
        275                 280                 285             

Ala Asn Pro Met Ala Met Ile Leu Ala Gly Ala Ala Leu Leu Gln Tyr 
    290                 295                 300                 

Ile Gln Asp Lys Asp Ala His Thr Val Ser Arg Ala Ile Tyr Glu Ala 
305                 310                 315                 320 

Thr Leu Glu Ser Ile Val Asp Gly Ile Arg Thr Ala Asp Leu Gly Gly 
                325                 330                 335     

His Ala Thr Thr Thr Glu Phe Thr Asp Glu Val Ile Arg Arg Val Arg 
            340                 345                 350         

Thr Lys Leu Glu Val Trp Ser Thr Phe Gly Asp Ala Val 
        355                 360                 365 

<210>   1320
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1310

<400>   1320
Met Thr Asp Met Gly Lys Pro Thr Ile Ile Val Met Glu Gly Asp Gln 
                5                   10                  15      

Thr Gly Gln Glu Leu Leu Glu Glu Ala Leu Arg Val Leu Ser Pro Asp 
            20                  25                  30          

Val Thr Gly Tyr Glu Ile Glu Ile Arg Lys Phe Asp Leu Ser Leu Glu 
        35                  40                  45              

Asn Arg Arg Arg Thr Gln Asn Ala Val Val His Glu Ala Ala Glu Ala 
    50                  55                  60                  

Met Arg Asp Thr Gly Leu Gly Leu Lys Ala Ala Thr Ile Thr Pro Glu 
65                  70                  75                  80  

Glu Lys Gly Asp Val Gly Ser Pro Asn Ala Ile Leu Arg Lys Glu Ile 
                85                  90                  95      

Asn Gly Thr Val Ile Val Arg Thr Gly Arg Arg Ile Pro Gly Ile Ala 
            100                 105                 110         

Pro Pro Val Gly Val Tyr Ser Pro Ile Ser Val Ile Arg Met Ala Val 
        115                 120                 125             

Asp Asp Ala Tyr Gly Ala Lys Glu Trp Arg Glu Gln Leu Glu Asn Gly 
    130                 135                 140                 

Asp Glu Val Ala Tyr Arg Thr Glu Lys Ile Ser Arg Ser Val Cys Arg 
145                 150                 155                 160 

Gly Val Ala Lys Tyr Ala Phe Gln His Ala Arg Arg Met His Ala Lys 
                165                 170                 175     

Val Phe Gly Gly Pro Lys Tyr Thr Val Ser Pro Val Tyr Glu Gly Met 
            180                 185                 190         

Leu Lys Glu Glu Met Asp Ala Ala Ala Lys Glu Tyr Pro Asp Val Lys 
        195                 200                 205             

Tyr Glu Pro Gln Leu Ile Asp Ala Thr Tyr Ala Leu Leu Leu Ala Arg 
    210                 215                 220                 

Ala Gly Glu Ala Leu Val Ile Pro Ala Leu Asn Arg Asp Gly Asp Cys 
225                 230                 235                 240 

Leu Ser Asp Leu Val Leu Gln Met Phe Gly Thr Ile Ala Gly Ser Glu 
                245                 250                 255     

Ser Leu Leu Leu Ser Leu Asp Glu Ser Phe Gln Pro Lys Val Val Met 
            260                 265                 270         

Ala Glu Ala Pro His Gly Thr Ala Pro Asn Leu Phe Arg Lys Asn Met 
        275                 280                 285             

Ala Asn Pro Met Ala Met Ile Leu Ala Gly Ala Ala Leu Leu Asn Tyr 
    290                 295                 300                 

Ile Gln Asp Lys Asp Ala His Thr Val Ser Arg Ala Ile Tyr Glu Ala 
305                 310                 315                 320 

Thr Leu Glu Ser Ile Val Asp Gly Ile Arg Thr Ala Asp Leu Gly Gly 
                325                 330                 335     

His Ala Thr Thr Thr Glu Phe Thr Asp Glu Val Ile Arg Arg Val Arg 
            340                 345                 350         

Thr Lys Leu Glu Val Trp Ser Thr Phe Gly Asp Ala Val 
        355                 360                 365 

<210>   1321
<211>   365
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1310

<400>   1321
Met Thr Asp Met Gly Lys Pro Thr Ile Ile Val Met Glu Gly Asp Gln 
                5                   10                  15      

Thr Gly Gln Glu Leu Leu Glu Glu Ala Leu Arg Val Leu Ser Pro Asp 
            20                  25                  30          

Val Thr Gly Tyr Glu Ile Glu Ile Arg Lys Phe Asp Leu Ser Leu Glu 
        35                  40                  45              

Asn Arg Arg Arg Thr Gln Asn Ala Val Val His Glu Ala Ala Glu Ala 
    50                  55                  60                  

Met Arg Asp Thr Gly Leu Gly Leu Lys Ala Ala Thr Ile Thr Pro Glu 
65                  70                  75                  80  

Glu Lys Gly Asp Val Gly Ser Pro Asn Ala Ile Leu Arg Lys Glu Ile 
                85                  90                  95      

Asn Gly Thr Val Ile Val Arg Thr Gly Arg Arg Ile Pro Gly Ile Ala 
            100                 105                 110         

Pro Pro Val Gly Val Tyr Ser Pro Ile Ser Val Ile Arg Met Ala Val 
        115                 120                 125             

Asp Asp Ala Tyr Gly Ala Lys Glu Trp Arg Glu Gln Leu Glu Gln Gly 
    130                 135                 140                 

Asp Glu Val Ala Tyr Arg Thr Glu Lys Ile Ser Arg Ser Val Cys Arg 
145                 150                 155                 160 

Gly Val Ala Lys Tyr Ala Phe Gln His Ala Arg Arg Met His Ala Lys 
                165                 170                 175     

Val Phe Gly Gly Pro Lys Tyr Thr Val Ser Pro Val Tyr Glu Gly Met 
            180                 185                 190         

Leu Lys Glu Glu Met Asp Ala Ala Ala Lys Glu Tyr Pro Asp Val Arg 
        195                 200                 205             

Tyr Glu Pro Gln Leu Ile Asp Ala Thr Tyr Ala Leu Leu Leu Ala Arg 
    210                 215                 220                 

Ala Gly Glu Ala Leu Val Ile Pro Ala Leu Asn Arg Asp Gly Asp Cys 
225                 230                 235                 240 

Leu Ser Asp Leu Val Leu Gln Met Phe Gly Thr Ile Ala Gly Ser Glu 
                245                 250                 255     

Ser Leu Leu Leu Ser Leu Asp Glu Ser Phe Gln Pro Lys Val Val Met 
            260                 265                 270         

Ala Glu Ala Pro His Gly Thr Ala Pro Asn Leu Phe Arg Lys Asn Met 
        275                 280                 285             

Ala Asn Pro Met Ala Met Ile Leu Ala Gly Ala Ala Leu Leu Asn Tyr 
    290                 295                 300                 

Ile Gln Asp Lys Asp Ala His Thr Val Ser Arg Ala Ile Tyr Glu Ala 
305                 310                 315                 320 

Thr Leu Glu Ser Ile Val Asp Gly Ile Arg Thr Ala Asp Leu Gly Gly 
                325                 330                 335     

His Ala Thr Thr Thr Glu Phe Thr Asp Glu Val Ile Arg Arg Val Arg 
            340                 345                 350         

Thr Lys Leu Glu Val Trp Ser Thr Phe Gly Asp Ala Val 
        355                 360                 365 

<210>   1322
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1311

<400>   1322
gtgacggaca tggggaaacc gaccatctta gtgatggagg gtgatcagac gggacaggag       60

cttctggagg aagcgctccg cgtgctgtcg cccgatgtca cggggtacga gattgagatt      120

cgcaagtttg atctgagcct cgaaaatcgc cggcgcacgc aaaatgccgt ggtgcacgag      180

gccgcagaag ccatgcggga cacgggcctc gggctcaagg ccgcgaccat cacgccggaa      240

gaaaagggcg acgtgggtag cccgaacgcc atcctgcgca aggaaatcaa cggcacggtg      300

attgtccgca ctggacgccg tatcccgggg atcgcgccgc cggtgggcgt ctactcgccc      360

atttcggtca tccgcatggc ggtggacgac gcctacggag ccaaggaatg gcgcgaacaa      420

ctggaaaacg gcgacgaggt ggcgtaccgc acggagaaaa tttcgcgatc cgtctgccgg      480

ggcgtggcca agtacgcgtt ccagcacgcg cgccgcatgc acgcgaaggt gtttggcggg      540

cccaaataca ccgtgagccc tgtgtacgaa ggcatgctga aggaagaaat ggacgccgcg      600

gccaaggaat atcccgacgt gcgctacgag ccgcagctca tcgacgcgac gtatgcgctc      660

ctcctggcgc gcgcgggtga agcactcgtc atcccggcgc tgaaccgcga cggcgactgc      720

ttgtccgatc tcgtcctcca gatgttcggc accatcgccg gatcagaatc actgcttctg      780

tcgctcgacg agtcgttcca gcccaaggtc gtgatggccg aagcgcctca tgggacggcg      840

cccaatctct tcaggaaaaa catggccaac ccgatggcca tgatcctggc cggcgccgcc      900

ctgttgaact acatccaaga caaggacgcc cacacggtat cgcgggccat ctacgaggcc      960

acgctcgagt ccattgtcga tgggattcgc acggccgatc tcggcggcca cgcgacgacc     1020

accgagttca cggacgaagt cattcggagg gttcggacga aactcgaggt ctggagcacg     1080

ttcggcgacg ccgtttga                                                   1098


<210>   1323
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1311

<400>   1323
gtgacggaca tggggaaacc gaccatcatc gtgatggagg gtgatcagac gggacaggag       60

cttctggagg aagcgctccg cgtgctgtcg cccgatgtca cggggtacga gattgagatt      120

cgcaagtttg atctgagcct cgaaaatcgc cggcgcacgc aaaatgccgt ggtgcacgag      180

gccgcagaag ccatgcggga cacgggcctc gggctcaagg ccgcgaccat cacgccggaa      240

gaaaagggcg acgtgggtag cccgaacgcc atcctgcgca aggaaatcaa cggcacggtg      300

attgtccgca ctggacgccg tatcccgggg atcgcgccgc cggtgggcgt ctactcgccc      360

atttcggtca tccgcatggc ggtggacgac gcctacggag ccaaggaatg gcgcgaacaa      420

ctggaaaacg gcgacgaggt ggcgtaccgc acggagaaaa tttcgcgatc cgtctgccgg      480

ggcgtggcca agtacgcgtt ccagcacgcg cgccgcatgc acgcgaaggt gtttggcggg      540

cccaaataca ccgtgagccc tgtgtacgaa ggcatgctga aggaagaaat ggacgccgcg      600

gccaaggaat atcccgacgt gcgctacgag ccgcagctca tcgacgcgac gtatgcgctc      660

ctcctggcgc gcgcgggtga agcactcgtc atcccggcgc tgaaccgcga cggcgactgc      720

ttgtccgatc tcgtcctcca gatgttcggc accatcgccg gatcagaatc actgcttctg      780

tcgctcgacg agtcgttcca gcccaaggtc gtgatggccg aagcgcctca tgggacggcg      840

cccaatctct tcaaaaaaaa catggccaac ccgatggcca tgatcctggc cggcgccgcc      900

ctgttgaact acatccaaga caaggacgcc cacacggtat cgcgggccat ctacgaggcc      960

acgctcgagt ccattgtcga tgggattcgc acggccgatc tcggcggcca cgcgacgacc     1020

accgagttca cggacgaagt cattcggagg gttcggacga aactcgaggt ctggagcacg     1080

ttcggcgacg ccgtttga                                                   1098


<210>   1324
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1311

<400>   1324
gtgacggaca tggggaaacc gaccatcatc gtgatggagg gtgatcagac gggacaggag       60

cttctggagg aagcgctccg cgtgctgtcg cccgatgtca cggggtacga gattgagatt      120

cgcaagtttg atctgagcct cgaaaatcgc cggcgcacgc aaaatgccgt ggtgcacgag      180

gccgcagaag ccatgcggga cacgggcctc gggctcaagg ccgcgaccat cacgccggaa      240

gaaaagggcg acgtgggtag cccgaacgcc atcctgcgca aggaaatcaa cggcacggtg      300

attgtccgca ctggacgccg tatcccgggg atcgcgccgc cggtgggcgt ctactcgccc      360

atttcggtca tccgcatggc ggtggacgac gcctacggag ccaaggaatg gcgcgaacaa      420

ctggaaaacg gcgacgaggt ggcgtaccgc acggagaaaa tttcgcgatc cgtctgccgg      480

ggcgtggcca agtacgcgtt ccagcacgcg cgccgcatgc acgcgaaggt gtttggcggg      540

cccaaataca ccgtgagccc tgtgtacgaa ggcatgctga aggaagaaat ggacgccgcg      600

gccaaggaat atcccgacgt gcgctacgag ccgcagctca tcgacgcgac gtatgcgctc      660

ctcctggcgc gcgcgggtga agcactcgtc atcccggcgc tgaaccgcga cggcgactgc      720

ttgtccgatc tcgtcctcca gatgttcggc accatcgccg gatcagaatc actgcttctg      780

tcgctcgacg agtcgttcca gcccaaggtc gtgatggccg aagcgcctca tgggacggcg      840

cccaatctct tcaggaaaaa catggccaac ccgatggcca tgatcctggc cggcgccgcc      900

ctgttgcaat acatccaaga caaggacgcc cacacggtat cgcgggccat ctacgaggcc      960

acgctcgagt ccattgtcga tgggattcgc acggccgatc tcggcggcca cgcgacgacc     1020

accgagttca cggacgaagt cattcggagg gttcggacga aactcgaggt ctggagcacg     1080

ttcggcgacg ccgtttga                                                   1098


<210>   1325
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1311

<400>   1325
gtgacggaca tggggaaacc gaccatcatc gtgatggagg gtgatcagac gggacaggag       60

cttctggagg aagcgctccg cgtgctgtcg cccgatgtca cggggtacga gattgagatt      120

cgcaagtttg atctgagcct cgaaaatcgc cggcgcacgc aaaatgccgt ggtgcacgag      180

gccgcagaag ccatgcggga cacgggcctc gggctcaagg ccgcgaccat cacgccggaa      240

gaaaagggcg acgtgggtag cccgaacgcc atcctgcgca aggaaatcaa cggcacggtg      300

attgtccgca ctggacgccg tatcccgggg atcgcgccgc cggtgggcgt ctactcgccc      360

atttcggtca tccgcatggc ggtggacgac gcctacggag ccaaggaatg gcgcgaacaa      420

ctggaaaacg gcgacgaggt ggcgtaccgc acggagaaaa tttcgcgatc cgtctgccgg      480

ggcgtggcca agtacgcgtt ccagcacgcg cgccgcatgc acgcgaaggt gtttggcggg      540

cccaaataca ccgtgagccc tgtgtacgaa ggcatgctga aggaagaaat ggacgccgcg      600

gccaaggaat atcccgacgt gaaatacgag ccgcagctca tcgacgcgac gtatgcgctc      660

ctcctggcgc gcgcgggtga agcactcgtc atcccggcgc tgaaccgcga cggcgactgc      720

ttgtccgatc tcgtcctcca gatgttcggc accatcgccg gatcagaatc actgcttctg      780

tcgctcgacg agtcgttcca gcccaaggtc gtgatggccg aagcgcctca tgggacggcg      840

cccaatctct tcaggaaaaa catggccaac ccgatggcca tgatcctggc cggcgccgcc      900

ctgttgaact acatccaaga caaggacgcc cacacggtat cgcgggccat ctacgaggcc      960

acgctcgagt ccattgtcga tgggattcgc acggccgatc tcggcggcca cgcgacgacc     1020

accgagttca cggacgaagt cattcggagg gttcggacga aactcgaggt ctggagcacg     1080

ttcggcgacg ccgtttga                                                   1098


<210>   1326
<211>   1098
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1311

<400>   1326
gtgacggaca tggggaaacc gaccatcatc gtgatggagg gtgatcagac gggacaggag       60

cttctggagg aagcgctccg cgtgctgtcg cccgatgtca cggggtacga gattgagatt      120

cgcaagtttg atctgagcct cgaaaatcgc cggcgcacgc aaaatgccgt ggtgcacgag      180

gccgcagaag ccatgcggga cacgggcctc gggctcaagg ccgcgaccat cacgccggaa      240

gaaaagggcg acgtgggtag cccgaacgcc atcctgcgca aggaaatcaa cggcacggtg      300

attgtccgca ctggacgccg tatcccgggg atcgcgccgc cggtgggcgt ctactcgccc      360

atttcggtca tccgcatggc ggtggacgac gcctacggag ccaaggaatg gcgcgaacaa      420

ctggaacaag gcgacgaggt ggcgtaccgc acggagaaaa tttcgcgatc cgtctgccgg      480

ggcgtggcca agtacgcgtt ccagcacgcg cgccgcatgc acgcgaaggt gtttggcggg      540

cccaaataca ccgtgagccc tgtgtacgaa ggcatgctga aggaagaaat ggacgccgcg      600

gccaaggaat atcccgacgt gcgctacgag ccgcagctca tcgacgcgac gtatgcgctc      660

ctcctggcgc gcgcgggtga agcactcgtc atcccggcgc tgaaccgcga cggcgactgc      720

ttgtccgatc tcgtcctcca gatgttcggc accatcgccg gatcagaatc actgcttctg      780

tcgctcgacg agtcgttcca gcccaaggtc gtgatggccg aagcgcctca tgggacggcg      840

cccaatctct tcaggaaaaa catggccaac ccgatggcca tgatcctggc cggcgccgcc      900

ctgttgaact acatccaaga caaggacgcc cacacggtat cgcgggccat ctacgaggcc      960

acgctcgagt ccattgtcga tgggattcgc acggccgatc tcggcggcca cgcgacgacc     1020

accgagttca cggacgaagt cattcggagg gttcggacga aactcgaggt ctggagcacg     1080

ttcggcgacg ccgtttga                                                   1098


<210>   1327
<211>   580
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1327
Met Pro Cys His Arg Glu Met Lys Gly Ala Ile Glu His Glu Glu Val 
                5                   10                  15      

Val Leu Met Asp Asp Leu Trp Thr Val Asp Gly Asp Asp Leu Arg Lys 
            20                  25                  30          

Leu Pro Tyr Gly Ala Met Tyr Ala Lys Phe Arg Trp Pro Thr Pro Asp 
        35                  40                  45              

Arg Leu Asn Ile Ala Glu Trp Ala Cys Arg Arg His Ala Arg Val Cys 
    50                  55                  60                  

Pro Asp Ala Pro Ala Ile Trp Tyr Asp Val Asp Gly Gly Ser Ala Glu 
65                  70                  75                  80  

Met Trp Thr Phe Gly His Leu Trp Arg Thr Thr Ser Arg Leu Ala Trp 
                85                  90                  95      

Ala Leu Leu Arg Gly Leu Gly Val Pro Thr Gly Gly Arg Val Ala Ile 
            100                 105                 110         

Leu Leu Pro Gln Ser Pro Gln Leu Ala Ala Ala His Leu Ala Ser Tyr 
        115                 120                 125             

Ala Ile Gly Ala Ile Ala Val Pro Leu Phe Thr Leu Phe Gly Thr Asp 
    130                 135                 140                 

Ala Leu Arg Tyr Arg Leu Gln Asp Ser Gly Ala Thr Val Val Val Thr 
145                 150                 155                 160 

Asp Ser Glu Gln Ala Asn Arg Ile Met Asp Ile Arg Ala Asp Leu Pro 
                165                 170                 175     

Asp Leu Glu His Val Ile Val Thr Asp Ala Arg Val Pro Gly Thr Gln 
            180                 185                 190         

Phe Trp Asp Asp Val Leu Ala Leu Ala Ser Ser Ala Glu Tyr His Pro 
        195                 200                 205             

Met Asp Ala Ser Pro Asp Asp Pro Ala Val Leu Ile Tyr Thr Ser Gly 
    210                 215                 220                 

Thr Thr Gly Ser Ala Lys Gly Ala Leu His Gly His Arg Ile Leu Leu 
225                 230                 235                 240 

Gly His Leu Pro Gly Val Ser Leu Pro His Asp Phe Ala Pro Gln Pro 
                245                 250                 255     

Gly Asp Val Phe Trp Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu 
            260                 265                 270         

Tyr Asp Val Leu Leu Pro Ala Leu Cys Trp Gly Val Pro Val Val Ala 
        275                 280                 285             

His Arg Ile Arg Lys Phe Asp Pro Glu Arg Ala Phe Ala Leu Met Glu 
    290                 295                 300                 

Arg Trp Arg Val Arg Asn Ala Phe Met Pro Pro Thr Ser Leu Lys Met 
305                 310                 315                 320 

Met Arg His Ile Thr Asp Pro Arg Ser Arg Trp His Leu His Leu Arg 
                325                 330                 335     

Thr Leu Ala Thr Gly Gly Glu Pro Leu Gly Ala Glu Leu Leu Ser Trp 
            340                 345                 350         

Ala Arg Glu Ala Leu Gly Leu Ser Ile His Glu Phe Tyr Gly Gln Thr 
        355                 360                 365             

Glu Cys Asn Leu Val Val Ala Asn Cys Ser Ala Cys Phe Gln Pro Lys 
    370                 375                 380                 

Pro Gly Ser Met Gly Arg Pro Val Pro Gly His Asp Val Ala Val Ile 
385                 390                 395                 400 

Asp Glu Asn Gly His Val Val Ser Pro Gly Val Ile Gly Glu Ile Ala 
                405                 410                 415     

Val Arg Arg Pro His Pro Val Met Phe Ile Gly Tyr Trp Asn Arg Pro 
            420                 425                 430         

Glu Glu Thr Ala Ala Lys Phe Val Gly Asp Trp Leu Lys Thr Gly Asp 
        435                 440                 445             

Leu Gly Arg Met Asp Glu Glu Gly Tyr Leu Trp Phe Val Gly Arg Ala 
    450                 455                 460                 

Asp Asp Val Ile Thr Ser Ala Gly Tyr Arg Ile Gly Pro Val Glu Ile 
465                 470                 475                 480 

Glu Glu Ala Ala Leu Gln His Ser Ala Val Val Met Ala Ala Ala Val 
                485                 490                 495     

Gly Thr Pro Asp Pro Val Arg Gly Glu Val Val Lys Leu Phe Val Lys 
            500                 505                 510         

Leu Arg Glu Gly Val Pro Ala Asn Glu Cys Leu Thr Ala Glu Leu Gln 
        515                 520                 525             

Asn Trp Val Lys Glu Arg Val Gly Ala His Ser Tyr Pro Arg Glu Ile 
    530                 535                 540                 

Glu Phe Val Asp Glu Leu Pro Leu Thr Pro Ser Gly Lys Val Arg Arg 
545                 550                 555                 560 

Arg Ala Leu Arg Glu Arg Glu Tyr Ala Gln Lys Gly Val Pro Leu Pro 
                565                 570                 575     

Gly Lys Arg Gly 
            580 

<210>   1328
<211>   1743
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1328
gtgccgtgcc acagggaaat gaaaggcgcg atcgagcatg aggaggtcgt tctcatggac       60

gacctttgga cggtggatgg ggacgatctg cggaagttgc cctacggggc gatgtatgcc      120

aagtttcggt ggcccacgcc ggatcggctg aatatcgccg agtgggcgtg tcgcaggcat      180

gcgcgggtgt gcccggatgc gcccgctatt tggtatgacg tcgacggtgg gtcggcggaa      240

atgtggacct tcggccatct gtggcgcacc acaagcaggt tggcctgggc tcttctgaga      300

ggccttgggg ttccaaccgg gggacgggtg gccatccttc tcccgcagtc tccccagctc      360

gcggcggccc acctcgcctc gtacgctatc ggggcgatcg cggtacccct gttcacgctg      420

ttcggaacgg acgcgcttcg ctaccggctc caggatagcg gcgccacagt cgtggtcacg      480

gacagcgaac aggcgaatcg gatcatggat atcagggccg atcttccaga cctcgagcac      540

gtcatcgtca cagacgcccg cgttccaggc acgcagtttt gggatgatgt cctcgccctc      600

gcgtcgtctg ctgaatacca cccgatggac gcttcgcccg acgatccggc tgtcctcatc      660

tacacctccg gcacaaccgg gtccgcgaag ggggcgcttc acggccatcg catcctgctc      720

ggccacctgc ctggcgtcag tcttccgcac gatttcgcgc cgcagccggg tgacgtcttc      780

tggacgcccg cggattgggc atggattggc gggctgtacg acgtgttgct gccagccctg      840

tgctggggtg tcccggtggt ggcgcatcgc atacgcaagt tcgatcccga acgtgccttc      900

gccctaatgg agcggtggcg cgttcgcaac gccttcatgc ctcccacgtc cctcaagatg      960

atgcgccata tcaccgaccc cagaagccga tggcatctac acctgcgcac gttggcgacg     1020

ggcggcgaac cgctcggcgc ggaacttctc tcgtgggctc gcgaggcgtt aggcctctcg     1080

attcacgagt tctacggcca gacggagtgc aatctggttg tcgccaactg cagcgcatgt     1140

ttccagccga agccgggttc catgggacga ccggtgccag gccacgatgt ggccgtgatc     1200

gacgaaaacg gccacgtggt atctcctggc gtgatcggcg agatcgccgt tcgccgtccg     1260

catccggtga tgttcatcgg ctattggaac cgccctgagg agaccgccgc gaagttcgtc     1320

ggggactggc tgaagacggg cgatctcggc cgcatggacg aggaaggcta tctgtggttc     1380

gtggggcgcg cggacgacgt catcacgtcg gcgggctacc ggatcggccc ggtggagatc     1440

gaggaggcgg cgcttcaaca ttcggccgtg gtcatggcgg cggccgttgg cacgcccgat     1500

cctgttcgcg gcgaggtggt gaagctcttt gtgaaactcc gtgagggcgt gcccgcgaac     1560

gagtgcctca ccgcggagct tcagaactgg gtcaaggagc gggtgggcgc gcacagctat     1620

ccgcgggaga tcgagttcgt cgacgaactt cccctcacgc cgtcgggcaa ggtgcgccgg     1680

cgagcgctgc gcgaacggga atacgcgcaa aagggcgtcc cgctgcccgg taagcgcggc     1740

tga                                                                   1743


<210>   1329
<211>   545
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   1329
Asp Asp Phe Trp Ala Ser Leu Thr Ser Arg Met Pro Arg Arg Leu Asp 
                5                   10                  15      

Tyr Glu Thr Leu Tyr Glu Gly Phe Ser Trp Asp Leu Pro Arg Pro Tyr 
            20                  25                  30          

Asn Ile Gly Thr Asp Val Cys Asp Arg His Ala Trp Glu Pro Gly Arg 
        35                  40                  45              

Leu Ala Leu Ile His Asp Arg Gly Asp Gly Thr Ala Glu Lys Trp Thr 
    50                  55                  60                  

Phe Arg Glu Leu Lys Leu Ala Ser Asp Arg Phe Ala Asn Ala Leu Arg 
65                  70                  75                  80  

Gly Leu Gly Val Glu Arg Gly Asp Arg Val Ala Val Leu Leu Ser Gln 
                85                  90                  95      

Thr Pro Gln Leu Pro Val Ala His Ile Ala Val Tyr Lys Leu Gly Ala 
            100                 105                 110         

Val Thr Val Pro Leu Phe Ala Leu Phe Gly Glu Asp Ala Leu Arg Phe 
        115                 120                 125             

Arg Leu Ser Asp Ser Gly Ala Arg Val Ile Val Thr Asp Glu Glu His 
    130                 135                 140                 

Phe Glu Val Ala Ala Ser Leu Arg Glu Glu Leu Glu Glu Leu Glu His 
145                 150                 155                 160 

Val Val Leu Thr Gly Gly Gly Arg Ala Gly Ala Leu Gly Phe Asp Asp 
                165                 170                 175     

Leu Val Arg Glu Ala Ser Pro Phe Phe Arg Pro Val Glu Thr Gly Pro 
            180                 185                 190         

Asp Asp Pro Ala Ile Ile Ile Tyr Thr Ser Gly Thr Thr Gly Ser Pro 
        195                 200                 205             

Lys Gly Ala Leu His Gly His Arg Ile Leu Leu Gly His Leu Pro Gly 
    210                 215                 220                 

Val Ser Leu Pro His Asp Leu Ala Pro Arg Arg Gly Asp Leu Phe Trp 
225                 230                 235                 240 

Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu Phe Asp Val Leu Phe 
                245                 250                 255     

Pro Ala Leu His Trp Gly Leu Pro Val Leu Ser Cys Arg Met Arg Arg 
            260                 265                 270         

Phe Asp Pro Glu Arg Ala Phe Asp Leu Met Glu Arg Trp Gly Val Arg 
        275                 280                 285             

Asn Val Phe Leu Pro Pro Thr Ala Leu Lys Met Met Arg Ala Val Gly 
    290                 295                 300                 

Ser Pro Arg Ser Arg Trp Arg Leu Glu Leu Glu Thr Leu Ala Cys Gly 
305                 310                 315                 320 

Gly Glu Pro Leu Gly Glu Glu Ser Leu Ala Trp Ala Arg Glu Glu Leu 
                325                 330                 335     

Gly Leu Pro Ile Asn Glu Phe Tyr Gly Gln Thr Glu Cys Asn Leu Val 
            340                 345                 350         

Leu Ser Asn Cys Ser Ala Ile Met Pro Ile Lys Pro Gly Ser Met Gly 
        355                 360                 365             

Arg Pro Val Pro Gly His Arg Val Ala Ile Ile Asp Ala Glu Gly Arg 
    370                 375                 380                 

Glu Leu Pro Pro Gly Glu Val Gly Glu Val Ala Val Leu Arg Pro Asp 
385                 390                 395                 400 

Pro Val Met Met Leu Gly Tyr Trp Asn Asn Glu Arg Ala Thr Glu Ala 
                405                 410                 415     

Lys Phe Val Gly Asp Trp Leu Arg Thr Gly Asp Leu Ala Thr Arg Asp 
            420                 425                 430         

Gly Glu Gly Tyr Phe Arg Phe Val Gly Arg Asp Asp Asp Val Ile Thr 
        435                 440                 445             

Ser Ser Gly Tyr Arg Ile Gly Pro Ala Glu Ile Glu Glu Thr Leu Val 
    450                 455                 460                 

Lys His Pro Arg Val Leu Met Ala Ala Ala Val Gly Arg Pro Asp Pro 
465                 470                 475                 480 

Val Arg Gly Glu Val Val Lys Ala Phe Val Val Leu Arg Glu Gly Glu 
                485                 490                 495     

Gly Asp Glu Ala Leu Ala Glu Glu Leu Lys Glu Leu Val Arg Arg Arg 
            500                 505                 510         

Leu Gly Ala His Glu Tyr Pro Arg Glu Val Glu Phe Val Pro Glu Leu 
        515                 520                 525             

Pro Leu Thr Ala Thr Gly Lys Ile Arg Arg Asn Val Leu Arg Ala Arg 
    530                 535                 540                 

Glu 
545 

<210>   1330
<211>   538
<212>   PRT
<213>   alpha proteobacterium BAL199

<400>   1330
Tyr Glu Ala Val Arg Glu Arg Phe Arg Trp Arg Ile Pro Gln Arg Tyr 
                5                   10                  15      

Asn Ile Gly Val Asp Val Cys Asp Arg His Ala Asp Ala Gly Ala Gly 
            20                  25                  30          

Thr Ala Leu Ile His Ile Ala Ala Asp Gly Ala Val Val Glu His Ser 
        35                  40                  45              

Phe Thr Glu Leu Lys Arg Gln Ser Asn Arg Leu Ala Asn Val Leu Thr 
    50                  55                  60                  

Ala Ala Gly Leu Gln Arg Gly Asp Arg Val Gly Ile Leu Met Pro Gln 
65                  70                  75                  80  

Arg Pro Glu Thr Ala Ile Ala His Ile Ala Ala His Lys Ala Gly Met 
                85                  90                  95      

Val Ser Val Pro Leu Phe Thr Leu Phe Gly Glu Asp Ala Leu Ala Tyr 
            100                 105                 110         

Arg Leu Gly Asp Cys Ala Ala Ala Ala Leu Val Thr Asp Arg Asp Ser 
        115                 120                 125             

Leu Pro Lys Ile Glu Ala Ile Arg Asp His Leu Pro Ser Leu Lys Leu 
    130                 135                 140                 

Ile Leu Val Ala Asp Thr Ala Lys Asn Gly Ser Gly Trp Arg Ala Leu 
145                 150                 155                 160 

Asp Leu Ala Leu Asp Ala Ala Ser Asp Ala Phe Thr Pro Val Asp Thr 
                165                 170                 175     

Ser Ala Asp Asp Pro Ala Val Ile Ile Tyr Thr Ser Gly Thr Thr Gly 
            180                 185                 190         

Gln Pro Lys Gly Ala Leu His Ala His Arg Val Leu Leu Gly His Leu 
        195                 200                 205             

Pro Gly Val Glu Phe Pro Gln Glu Phe Phe Pro Ala Pro Gly Asp Arg 
    210                 215                 220                 

Phe Trp Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu Leu Asp Val 
225                 230                 235                 240 

Leu Leu Pro Ser Leu His His Gly Ile Pro Val Val Ala His Arg Phe 
                245                 250                 255     

Ala Lys Phe Asp Pro Glu Ala Ala Phe Asp Leu Ile Ala Arg His Arg 
            260                 265                 270         

Val Arg Asn Ser Phe Leu Pro Pro Thr Ala Leu Lys Leu Met Arg Gln 
        275                 280                 285             

Val Pro Asp Pro Leu Ala Arg His Ala Leu Ala Met Arg Ser Ile Gly 
    290                 295                 300                 

Ser Gly Gly Glu Thr Leu Gly Thr Glu Leu Leu Glu Trp Gly Arg Ser 
305                 310                 315                 320 

Val Phe Gly Leu Thr Ile Asn Glu Phe Tyr Gly Gln Thr Glu Cys Asn 
                325                 330                 335     

Leu Val Val Gly Asn Cys Ala Ser Ile Leu Pro Val Arg Pro Gly Ser 
            340                 345                 350         

Met Gly Lys Pro Val Pro Gly His Glu Val Ala Ile Val Asp Ala Asn 
        355                 360                 365             

Gly Ile Pro Leu Pro Ala Ser Glu Thr Gly Ala Ile Ala Val Lys Arg 
    370                 375                 380                 

Gly Asp Pro Val Met Phe Leu Gly Tyr Trp Asn Asn Pro Gln Ala Thr 
385                 390                 395                 400 

Asp Ala Lys Phe Thr Gly Pro Asp Lys Gln Trp Met Leu Thr Gly Asp 
                405                 410                 415     

Leu Gly Arg Gln Asp Glu Asp Gly Tyr Leu His Tyr Val Gly Arg Asp 
            420                 425                 430         

Asp Asp Val Ile Thr Ser Ala Gly Tyr Arg Ile Gly Pro Gly Glu Ile 
        435                 440                 445             

Glu Asp Cys Leu Thr Ala His Pro Ser Val Ala Leu Ala Ala Val Ile 
    450                 455                 460                 

Gly Val Pro Asp Pro Leu Arg Thr Glu Ala Ile Lys Ala Cys Val Val 
465                 470                 475                 480 

Leu Ala Asp Gly Val Ala Pro Ser Asp Ser Leu Lys Ala Glu Ile Gln 
                485                 490                 495     

Asn His Val Lys Arg Arg Leu Ala Ala His Glu Tyr Pro Arg Ile Val 
            500                 505                 510         

Glu Phe Val Asp Ser Leu Pro Met Thr Thr Thr Gly Lys Ile Met Arg 
        515                 520                 525             

Arg Val Leu Arg Glu Arg His Ala Ala Glu 
    530                 535             

<210>   1331
<211>   530
<212>   PRT
<213>   Stappia aggregata IAM 12614

<400>   1331
Tyr Asp Asp Leu Ser Gly Arg Phe Lys Trp Glu Ile Pro Asp Arg Phe 
                5                   10                  15      

Asn Ile Gly Val Ala Ile Cys Asp Asp Trp Ala Ala Arg Glu Pro Asn 
            20                  25                  30          

Arg Glu Ala Leu Val Tyr Thr Asp Glu Asp Gly Ser Ala Thr Ser Tyr 
        35                  40                  45              

Thr Tyr Asp Asp Leu Arg Arg Leu Ser Asn Gln Leu Ala Asn Leu Leu 
    50                  55                  60                  

Thr Ala Arg Gly Val Gln Pro Gly Asp Arg Ile Gly Val Leu Met Pro 
65                  70                  75                  80  

Gln Arg Pro Glu Thr Ala Phe Ala His Ile Ala Ala Leu Lys Leu Gly 
                85                  90                  95      

Ala Ile Ser Ile Pro Leu Phe Thr Leu Phe Gly Glu Glu Ala Leu Glu 
            100                 105                 110         

Tyr Arg Leu Lys Asp Ser Gly Ala Lys Val Val Ile Thr Asp Ala Ser 
        115                 120                 125             

Gly Ala Ala Lys Leu Ala Thr Ile Arg Asp Arg Leu Pro Glu Leu Thr 
    130                 135                 140                 

Thr Val Leu Cys Ala Asp Glu Asp Val Pro Trp Ala Glu Ser Leu His 
145                 150                 155                 160 

His His Met Ala Gly His Glu Gly Thr Phe His Pro Phe Asp Thr Gly 
                165                 170                 175     

Pro Asp Asp Pro Ala Ile Ile Ile Tyr Thr Ser Gly Thr Thr Gly Gln 
            180                 185                 190         

Pro Lys Gly Ala Leu His Gly His Arg Val Leu Leu Gly His Leu Pro 
        195                 200                 205             

Gly Val Glu Met Ser His Asp Leu Leu Gly Gln Pro Gly Asp Arg Ile 
    210                 215                 220                 

Trp Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu Leu Asp Val Leu 
225                 230                 235                 240 

Met Pro Ala Leu Tyr Leu Gly Val Pro Val Val Ala Cys Arg Phe Arg 
                245                 250                 255     

Lys Phe Thr Ala Glu Ala Ala Phe Gln Leu Leu Gln Asp Gln Lys Ile 
            260                 265                 270         

Arg Asn Thr Phe Leu Pro Pro Thr Ala Leu Lys Met Met Arg Gln Val 
        275                 280                 285             

Glu Ala Pro Glu Lys Arg Trp Arg Phe Thr Leu Arg Ser Val Ala Ser 
    290                 295                 300                 

Gly Gly Glu Thr Leu Gly Ala Glu Leu Ile Asp Trp Gly Arg Arg Thr 
305                 310                 315                 320 

Phe Gly Leu Thr Ile Asn Glu Phe Tyr Gly Gln Thr Glu Cys Asn Met 
                325                 330                 335     

Ile Val Ser Ser Cys Ala Arg Leu Met Glu Ala Arg Pro Gly Ile Met 
            340                 345                 350         

Gly Arg Pro Val Pro Gly His His Val Ser Val Val Ser Asp Lys Gly 
        355                 360                 365             

Glu Glu Leu Pro Ala Gly Thr Leu Gly Asn Ile Ala Val Lys Arg Pro 
    370                 375                 380                 

Asp Pro Val Met Phe Leu Asn Tyr Trp Asn Asn Met Glu Ala Thr Glu 
385                 390                 395                 400 

Lys Lys Phe Ala Gly Asp Trp Leu Leu Thr Gly Asp Thr Gly Ile Lys 
                405                 410                 415     

Asp Asp Thr Gly Trp Ile Arg Phe Val Gly Arg Asp Asp Asp Val Ile 
            420                 425                 430         

Thr Ser Ser Gly Tyr Arg Ile Gly Pro Gly Glu Ile Glu Asp Cys Leu 
        435                 440                 445             

Ile Lys His Pro Ala Val Ala Met Ala Gly Val Val Gly Lys Pro Asp 
    450                 455                 460                 

Ser Gln Arg Thr Glu Ile Val Lys Ala Tyr Ile Val Leu Lys Lys Gly 
465                 470                 475                 480 

Phe Glu Pro Thr Asp Lys Leu Ala Gly Glu Ile Ala Asp Phe Val Lys 
                485                 490                 495     

Thr Arg Leu Ala Ala His Glu Tyr Pro Arg Glu Val Ala Phe Val Asp 
            500                 505                 510         

Ala Leu Pro Leu Thr Thr Thr Gly Lys Val Ile Arg Arg Glu Leu Arg 
        515                 520                 525             

Ala Arg 
    530 

<210>   1332
<211>   530
<212>   PRT
<213>   Methylobacterium sp. 4-46

<400>   1332
Tyr Glu Ala Phe Arg Ser Gly Phe Arg Trp Arg Ile Pro Glu Arg Tyr 
                5                   10                  15      

Asn Ile Ala Val Asp Val Cys Asp Arg Trp Ala Ala Ala Asp Pro Gln 
            20                  25                  30          

Arg Pro Ala Leu Leu Asp Val Ser Ala Asp Gly Arg Val Glu Thr Trp 
        35                  40                  45              

Ser Phe Ala Ala Leu Arg Glu Ala Ser Asp Arg Phe Ala Asn Ala Leu 
    50                  55                  60                  

Arg Ala Leu Gly Ile Ala Arg Gly Asp Arg Val Ala Val Leu Leu Pro 
65                  70                  75                  80  

Gln Ser Pro Ala Val Leu Ile Ala His Leu Ala Val Tyr Lys Leu Gly 
                85                  90                  95      

Ala Val Ala Leu Pro Leu Ala Val Val Phe Gly Pro Asp Ala Leu Leu 
            100                 105                 110         

His Arg Leu Gly Asp Ser Gly Ala Lys Ala Val Val Thr His Ala Gly 
        115                 120                 125             

Gly Val Ala Lys Leu Leu Pro Leu Arg Asp Ala Leu Pro Glu Leu Ala 
    130                 135                 140                 

Leu Val Val Ser Thr Asp Gly Pro Gly Asp Gly Ala Leu Gly Phe Ala 
145                 150                 155                 160 

Ala Leu Leu Glu Ala Ala Ala Pro Ala Leu Ala Pro Val Glu Thr Gly 
                165                 170                 175     

Pro Asp Asp Pro Ala Leu Met Ile Tyr Thr Ser Gly Thr Thr Gly Pro 
            180                 185                 190         

Pro Lys Gly Ala Leu His Gly His Arg Val Leu Leu Gly His Leu Pro 
        195                 200                 205             

Gly Phe Ala Met Met His Asp Phe Met Pro Arg Pro Gly Asp Arg Met 
    210                 215                 220                 

Trp Thr Pro Ala Asp Trp Ala Trp Ala Gly Gly Leu Leu Asn Ala Leu 
225                 230                 235                 240 

Leu Pro Ser Leu His His Gly Val Ala Val Val Ala Arg Lys Ala Glu 
                245                 250                 255     

Lys Phe Glu Pro Glu Glu Ala Leu Arg Leu Ile Ala Asp His Ala Val 
            260                 265                 270         

Ala Asn Ala Phe Val Pro Pro Thr Ala Leu Arg Met Leu Arg Thr Val 
        275                 280                 285             

Ala Arg Pro Arg Ala Arg Phe Asp Leu Ser Arg Leu Arg Thr Leu Ala 
    290                 295                 300                 

Ser Ala Gly Glu Met Leu Gly Pro Glu Thr Phe Ala Trp Ala Arg Asp 
305                 310                 315                 320 

Ala Leu Gly Leu Thr Val Asn Glu Ala Tyr Gly Gln Thr Glu Cys Asn 
                325                 330                 335     

Leu Val Leu Ala Ser Cys Ala Ala Leu Gly Leu Ala Arg Ala Gly Ser 
            340                 345                 350         

Thr Gly Lys Pro Val Pro Gly His Arg Val Ala Val Ile Arg Pro Asp 
        355                 360                 365             

Gly Thr Ala Ala Asp Pro Asp Glu Ile Gly Gln Ile Ala Val Ala Arg 
    370                 375                 380                 

Pro Asp Pro Val Met Phe Leu Gly Tyr Trp Arg Asp Glu Ala Ala Thr 
385                 390                 395                 400 

Ala Arg Lys Phe Leu Gly Asp Trp Met Thr Thr Gly Asp Gln Gly Arg 
                405                 410                 415     

Val Asp Ala Asp Gly Tyr Val His Phe Val Gly Arg Asp Asp Asp Val 
            420                 425                 430         

Ile Thr Ser Ser Gly Tyr Arg Ile Gly Pro Gly Glu Ile Glu Asp Cys 
        435                 440                 445             

Leu Leu Arg His Pro Ala Val Ala Leu Ala Ala Ala Val Gly Lys Pro 
    450                 455                 460                 

Asp Pro Val Arg Thr Glu Ile Val Lys Ala Phe Val Val Leu Arg Pro 
465                 470                 475                 480 

Gly Phe Ala Ala Ser Ala Ala Leu Ala Thr Glu Ile Gln Asp Phe Val 
                485                 490                 495     

Arg Arg His Leu Ser Ala His Glu Tyr Pro Arg Glu Ile Ala Phe Arg 
            500                 505                 510         

Ser Ser Leu Pro Leu Thr Thr Thr Gly Lys Ile Ile Arg Arg Val Leu 
        515                 520                 525             

Arg Asp 
    530 

<210>   1333
<211>   520
<212>   PRT
<213>   Rhodobacterales bacterium HTCC2654

<400>   1333
Trp Ala Ala Leu Arg Arg Ala Phe Arg Trp Thr Val Pro Asp Gly Phe 
                5                   10                  15      

Asn Met Ala Asp Ala Cys Cys Asp Ser Trp Ala Arg Asp Glu Pro Gly 
            20                  25                  30          

Arg Val Ala Val Thr His Val Gly His Glu Thr Arg Asp Trp Thr Phe 
        35                  40                  45              

Gly Glu Leu Lys Asp Ala Ser Asp Arg Leu Ala Gly Ala Phe Ala Asp 
    50                  55                  60                  

Ala Gly Val Gly Arg Gly Asp Arg Val Gly Val Leu Leu Gly Gln Ser 
65                  70                  75                  80  

Pro Glu Thr Leu Ile Ala His Leu Ala Thr Trp Lys Arg Gly Gly Ile 
                85                  90                  95      

Ser Ile Pro Leu Phe Ser Leu Phe Gly Pro Asp Ala Leu Ala Phe Arg 
            100                 105                 110         

Leu Ala Asp Ser Gly Thr Lys Ala Val Val Thr Asp Ala Ala Gly Ala 
        115                 120                 125             

Glu Lys Leu Ala Ala Val Arg Gly Glu Leu Pro Asp Leu Ala Gln Val 
    130                 135                 140                 

Phe Ala Val Gly Gly Gly Thr Gly Arg Asp Phe Trp Ala Glu Val Glu 
145                 150                 155                 160 

Ala Ala Ser Pro Val Asp Pro Val Pro Val Gly Ala Glu Asp Pro Ala 
                165                 170                 175     

Val Ile Ile Tyr Thr Ser Gly Thr Thr Gly Pro Pro Lys Gly Ala Leu 
            180                 185                 190         

His Ala His Arg Phe Leu Ile Gly His Leu Pro Ser Val Glu Leu His 
        195                 200                 205             

His Glu Gly Phe Pro His Pro Gly Asp Val Gly Trp Thr Pro Ala Asp 
    210                 215                 220                 

Trp Ala Trp Ile Gly Gly Leu Met Asp Met Ala Met Pro Cys Leu Tyr 
225                 230                 235                 240 

His Gly Val Arg Leu Val Ser Cys Arg Met Arg Lys Phe Asp Ala Asp 
                245                 250                 255     

Glu Ala Tyr Arg Leu Ile Ala Asp Gln Arg Val Arg Asn Leu Phe Leu 
            260                 265                 270         

Pro Pro Thr Ala Leu Lys Leu Met Arg Gln Ala Glu Val Pro Glu Asp 
        275                 280                 285             

Val Asp Ile Arg Thr Ile Gly Ser Gly Gly Glu Ala Leu Gly Ala Asp 
    290                 295                 300                 

Leu Leu Ala Trp Ala Gln Asp Ala Leu Gly Val Thr Ile Asn Glu Phe 
305                 310                 315                 320 

Tyr Gly Gln Thr Glu Cys Asn Leu Val Leu Ala Ser Cys Ala Gly Ser 
                325                 330                 335     

Met Ala Val Lys Pro Gly Ser Met Gly Gln Ala Val Pro Gly His Glu 
            340                 345                 350         

Val Ala Val Ile Asp Ala Glu Gly Gln Val Val Ala Pro Gly Thr Val 
        355                 360                 365             

Gly Glu Ile Ala Val Lys Arg Pro Asp Pro Val Met Phe Leu Gly Tyr 
    370                 375                 380                 

Trp Asn Leu Pro Glu Lys Thr Ala Ala Lys Phe Thr Gly Asp Trp Met 
385                 390                 395                 400 

Arg Thr Gly Asp Leu Gly Val Cys Asp Glu Asp Gly Tyr Phe Thr Tyr 
                405                 410                 415     

Val Ser Arg Asp Asp Asp Val Ile Thr Ser Ala Gly Tyr Arg Ile Gly 
            420                 425                 430         

Pro Thr Glu Ile Glu Thr Cys Leu Thr Gly His Pro Asp Val Val Met 
        435                 440                 445             

Ala Ala Ala Val Gly Val Pro Asp Glu Thr Arg Gly Glu Val Val Lys 
    450                 455                 460                 

Ala Tyr Val Val Leu Arg Asp Gly Ala Ala Thr Glu Gly Leu Ala Asp 
465                 470                 475                 480 

Arg Leu Ile Gln Arg Val Arg Glu Lys Val Ser Pro His Val Ala Pro 
                485                 490                 495     

Arg Ile Val Glu Phe Val Asp Asp Leu Pro Met Thr Ala Thr Gly Lys 
            500                 505                 510         

Ile Met Arg Arg Ser Leu Arg Asp 
        515                 520 

<210>   1334
<211>   580
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1327

<400>   1334
Met Pro Cys His Arg Glu Met Lys Gly Ala Ile Glu His Glu Glu Val 
                5                   10                  15      

Val Leu Met Asp Asp Leu Trp Thr Val Asp Gly Asp Asp Leu Arg Lys 
            20                  25                  30          

Leu Pro Tyr Gly Ala Met Tyr Ala Lys Phe Arg Trp Pro Thr Pro Asp 
        35                  40                  45              

Arg Leu Asn Ile Ala Glu Trp Ala Cys Arg Arg His Ala Arg Val Cys 
    50                  55                  60                  

Pro Asp Ala Pro Ala Ile Trp Tyr Asp Val Asp Gly Gly Ser Ala Glu 
65                  70                  75                  80  

Met Trp Thr Phe Gly His Leu Trp Arg Thr Thr Ser Arg Leu Ala Trp 
                85                  90                  95      

Ala Leu Leu Arg Gly Leu Gly Val Pro Thr Gly Gly Arg Val Ala Ile 
            100                 105                 110         

Leu Leu Pro Gln Ser Pro Gln Leu Ala Ala Ala His Leu Ala Ser Tyr 
        115                 120                 125             

Ala Ile Gly Ala Ile Ala Val Pro Leu Phe Thr Leu Phe Gly Thr Asp 
    130                 135                 140                 

Ala Leu Arg Tyr Arg Leu Gln Asp Ser Gly Ala Thr Val Val Val Thr 
145                 150                 155                 160 

Asp Ser Glu Gln Ala Asn Arg Ile Met Asp Ile Arg Ala Asp Leu Pro 
                165                 170                 175     

Asp Leu Glu His Val Ile Val Thr Asp Ala Arg Val Pro Gly Thr Gln 
            180                 185                 190         

Phe Trp Asp Asp Val Leu Ala Leu Ala Ser Ser Ala Glu Tyr His Pro 
        195                 200                 205             

Met Asp Ala Ser Pro Asp Asp Pro Ala Val Leu Ile Tyr Thr Ser Gly 
    210                 215                 220                 

Thr Thr Gly Ser Ala Lys Gly Ala Leu His Gly His Arg Ile Leu Leu 
225                 230                 235                 240 

Gly His Leu Pro Gly Val Ser Leu Pro His Asp Phe Ala Pro Gln Pro 
                245                 250                 255     

Gly Asp Val Phe Trp Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu 
            260                 265                 270         

Tyr Asp Val Leu Leu Pro Ala Leu Cys Trp Gly Val Pro Val Val Ala 
        275                 280                 285             

His Arg Ile Arg Lys Phe Asp Pro Glu Arg Ala Phe Ala Leu Met Glu 
    290                 295                 300                 

Arg Trp Arg Val Arg Asn Ala Phe Met Pro Pro Thr Ser Leu Lys Met 
305                 310                 315                 320 

Met Arg His Ile Thr Asp Pro Arg Ser Arg Trp His Leu His Leu Arg 
                325                 330                 335     

Thr Leu Ala Thr Gly Gly Glu Pro Leu Gly Ala Glu Leu Leu Ser Trp 
            340                 345                 350         

Ala Arg Glu Ala Leu Gly Leu Ser Ile His Glu Phe Tyr Gly Gln Thr 
        355                 360                 365             

Glu Cys Asn Leu Val Val Ala Asn Cys Ser Ala Cys Phe Gln Pro Lys 
    370                 375                 380                 

Pro Gly Ser Met Gly Arg Pro Val Pro Gly His Asp Val Ala Val Ile 
385                 390                 395                 400 

Asp Glu Asn Gly His Val Ile Ser Pro Gly Val Ile Gly Glu Ile Ala 
                405                 410                 415     

Val Arg Arg Pro His Pro Val Met Phe Ile Gly Tyr Trp Asn Arg Pro 
            420                 425                 430         

Glu Glu Thr Ala Ala Lys Phe Val Gly Asp Trp Leu Lys Thr Gly Asp 
        435                 440                 445             

Leu Gly Arg Met Asp Glu Glu Gly Tyr Leu Trp Phe Val Gly Arg Ala 
    450                 455                 460                 

Asp Asp Val Ile Thr Ser Ala Gly Tyr Arg Ile Gly Pro Val Glu Ile 
465                 470                 475                 480 

Glu Glu Ala Ala Leu Gln His Ser Ala Val Val Met Ala Ala Ala Val 
                485                 490                 495     

Gly Thr Pro Asp Pro Val Arg Gly Glu Val Val Lys Leu Phe Val Lys 
            500                 505                 510         

Leu Arg Glu Gly Val Pro Ala Asn Glu Cys Leu Thr Ala Glu Leu Gln 
        515                 520                 525             

Asn Trp Val Lys Glu Arg Val Gly Ala His Ser Tyr Pro Arg Glu Ile 
    530                 535                 540                 

Glu Phe Val Asp Glu Leu Pro Leu Thr Pro Ser Gly Lys Val Arg Arg 
545                 550                 555                 560 

Arg Ala Leu Arg Glu Arg Glu Tyr Ala Gln Lys Gly Val Pro Leu Pro 
                565                 570                 575     

Gly Lys Arg Gly 
            580 

<210>   1335
<211>   580
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1327

<400>   1335
Met Pro Cys His Arg Glu Met Lys Gly Ala Ile Glu His Glu Glu Val 
                5                   10                  15      

Val Leu Met Asp Glu Leu Trp Thr Val Asp Gly Asp Asp Leu Arg Lys 
            20                  25                  30          

Leu Pro Tyr Gly Ala Met Tyr Ala Lys Phe Arg Trp Pro Thr Pro Asp 
        35                  40                  45              

Arg Leu Asn Ile Ala Glu Trp Ala Cys Arg Arg His Ala Arg Val Cys 
    50                  55                  60                  

Pro Asp Ala Pro Ala Ile Trp Tyr Asp Val Asp Gly Gly Ser Ala Glu 
65                  70                  75                  80  

Met Trp Thr Phe Gly His Leu Trp Arg Thr Thr Ser Arg Leu Ala Trp 
                85                  90                  95      

Ala Leu Leu Arg Gly Leu Gly Val Pro Thr Gly Gly Arg Val Ala Ile 
            100                 105                 110         

Leu Leu Pro Gln Ser Pro Gln Leu Ala Ala Ala His Leu Ala Ser Tyr 
        115                 120                 125             

Ala Ile Gly Ala Ile Ala Val Pro Leu Phe Thr Leu Phe Gly Thr Asp 
    130                 135                 140                 

Ala Leu Arg Tyr Arg Leu Gln Asp Ser Gly Ala Thr Val Val Val Thr 
145                 150                 155                 160 

Asp Ser Glu Gln Ala Asn Arg Ile Met Asp Ile Arg Ala Asp Leu Pro 
                165                 170                 175     

Asp Leu Glu His Val Ile Val Thr Asp Ala Arg Val Pro Gly Thr Gln 
            180                 185                 190         

Phe Trp Asp Asp Val Leu Ala Leu Ala Ser Ser Ala Glu Tyr His Pro 
        195                 200                 205             

Met Asp Ala Ser Pro Asp Asp Pro Ala Val Leu Ile Tyr Thr Ser Gly 
    210                 215                 220                 

Thr Thr Gly Ser Ala Lys Gly Ala Leu His Gly His Arg Ile Leu Leu 
225                 230                 235                 240 

Gly His Leu Pro Gly Val Ser Leu Pro His Asp Phe Ala Pro Gln Pro 
                245                 250                 255     

Gly Asp Val Phe Trp Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu 
            260                 265                 270         

Tyr Asp Val Leu Leu Pro Ala Leu Cys Trp Gly Val Pro Val Val Ala 
        275                 280                 285             

His Arg Ile Arg Lys Phe Asp Pro Glu Arg Ala Phe Ala Leu Met Glu 
    290                 295                 300                 

Arg Trp Arg Val Arg Asn Ala Phe Met Pro Pro Thr Ser Leu Lys Met 
305                 310                 315                 320 

Met Arg His Ile Thr Asp Pro Arg Ser Arg Trp His Leu His Leu Arg 
                325                 330                 335     

Thr Leu Ala Thr Gly Gly Glu Pro Leu Gly Ala Glu Leu Leu Ser Trp 
            340                 345                 350         

Ala Arg Glu Ala Leu Gly Leu Ser Ile His Glu Phe Tyr Gly Gln Thr 
        355                 360                 365             

Glu Cys Asn Leu Val Val Ala Asn Cys Ser Ala Cys Phe Gln Pro Lys 
    370                 375                 380                 

Pro Gly Ser Met Gly Arg Pro Val Pro Gly His Asp Val Ala Val Ile 
385                 390                 395                 400 

Asp Glu Asn Gly His Val Val Ser Pro Gly Val Ile Gly Glu Ile Ala 
                405                 410                 415     

Val Arg Arg Pro His Pro Val Met Phe Ile Gly Tyr Trp Asn Arg Pro 
            420                 425                 430         

Glu Glu Thr Ala Ala Lys Phe Val Gly Asp Trp Leu Lys Thr Gly Asp 
        435                 440                 445             

Leu Gly Arg Met Asp Glu Glu Gly Tyr Leu Trp Phe Val Gly Arg Ala 
    450                 455                 460                 

Asp Asp Val Ile Thr Ser Ala Gly Tyr Arg Ile Gly Pro Val Glu Ile 
465                 470                 475                 480 

Glu Glu Ala Ala Leu Gln His Ser Ala Val Val Met Ala Ala Ala Val 
                485                 490                 495     

Gly Thr Pro Asp Pro Val Arg Gly Glu Val Val Lys Leu Phe Val Lys 
            500                 505                 510         

Leu Arg Glu Gly Val Pro Ala Asn Glu Cys Leu Thr Ala Glu Leu Gln 
        515                 520                 525             

Asn Trp Val Lys Glu Arg Val Gly Ala His Ser Tyr Pro Arg Glu Ile 
    530                 535                 540                 

Glu Phe Val Asp Glu Leu Pro Leu Thr Pro Ser Gly Lys Val Arg Arg 
545                 550                 555                 560 

Arg Ala Leu Arg Glu Arg Glu Tyr Ala Gln Lys Gly Val Pro Leu Pro 
                565                 570                 575     

Gly Lys Arg Gly 
            580 

<210>   1336
<211>   580
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1327

<400>   1336
Met Pro Cys His Arg Glu Met Lys Gly Ala Ile Glu His Glu Glu Val 
                5                   10                  15      

Val Leu Met Asp Asp Leu Trp Thr Val Asp Gly Asp Asp Leu Arg Lys 
            20                  25                  30          

Leu Pro Tyr Gly Ala Met Tyr Ala Lys Phe Arg Trp Pro Thr Pro Asp 
        35                  40                  45              

Arg Leu Asn Ile Ala Glu Trp Ala Cys Arg Arg His Ala Arg Val Cys 
    50                  55                  60                  

Pro Asp Ala Pro Ala Ile Trp Tyr Asp Val Asp Gly Gly Ser Ala Glu 
65                  70                  75                  80  

Met Trp Thr Phe Gly His Leu Trp Arg Thr Thr Ser Arg Leu Ala Trp 
                85                  90                  95      

Ala Leu Leu Arg Gly Leu Gly Val Pro Thr Gly Gly Arg Val Ala Ile 
            100                 105                 110         

Leu Leu Pro Gln Ser Pro Gln Leu Ala Ala Ala His Leu Ala Ser Tyr 
        115                 120                 125             

Ala Ile Gly Ala Ile Ala Val Pro Leu Phe Thr Leu Phe Gly Thr Asp 
    130                 135                 140                 

Ala Leu Arg Tyr Arg Leu Gln Asp Ser Gly Ala Thr Val Val Val Thr 
145                 150                 155                 160 

Asp Ser Glu Gln Ala Asn Arg Ile Met Asp Ile Arg Ala Asp Leu Pro 
                165                 170                 175     

Asp Leu Glu His Val Ile Val Thr Asp Ala Arg Val Pro Gly Thr Gln 
            180                 185                 190         

Phe Trp Asp Asp Val Leu Ala Leu Ala Ser Ser Ala Glu Tyr His Pro 
        195                 200                 205             

Met Asp Ala Ser Pro Asp Asp Pro Ala Val Leu Ile Tyr Thr Ser Gly 
    210                 215                 220                 

Thr Thr Gly Ser Ala Lys Gly Ala Leu His Gly His Arg Ile Leu Leu 
225                 230                 235                 240 

Gly His Leu Pro Gly Val Ser Leu Pro His Asp Phe Ala Pro Gln Pro 
                245                 250                 255     

Gly Asp Val Phe Trp Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu 
            260                 265                 270         

Tyr Asp Val Leu Leu Pro Ala Leu Cys Trp Gly Val Pro Val Val Ala 
        275                 280                 285             

His Arg Ile Arg Lys Phe Asp Pro Glu Arg Ala Phe Ala Leu Met Glu 
    290                 295                 300                 

Arg Trp Arg Val Arg Asn Ala Phe Met Pro Pro Thr Ser Leu Lys Met 
305                 310                 315                 320 

Met Arg His Ile Thr Asp Pro Arg Ser Arg Trp His Leu His Leu Arg 
                325                 330                 335     

Thr Leu Ala Thr Gly Gly Glu Pro Leu Gly Ala Glu Leu Leu Ser Trp 
            340                 345                 350         

Ala Arg Glu Ala Leu Gly Leu Ser Ile His Glu Phe Tyr Gly Gln Thr 
        355                 360                 365             

Glu Cys Asn Leu Val Val Ala Asn Cys Ser Ala Cys Phe Gln Pro Lys 
    370                 375                 380                 

Pro Gly Ser Met Gly Arg Pro Val Pro Gly His Asp Val Ala Val Ile 
385                 390                 395                 400 

Asp Glu Asn Gly His Val Val Ser Pro Gly Val Ile Gly Glu Ile Ala 
                405                 410                 415     

Val Arg Arg Pro His Pro Val Met Phe Ile Gly Tyr Trp Asn Arg Pro 
            420                 425                 430         

Glu Asp Thr Ala Ala Lys Phe Val Gly Asp Trp Leu Lys Thr Gly Asp 
        435                 440                 445             

Leu Gly Arg Met Asp Glu Glu Gly Tyr Leu Trp Phe Val Gly Arg Ala 
    450                 455                 460                 

Asp Asp Val Ile Thr Ser Ala Gly Tyr Arg Ile Gly Pro Val Glu Ile 
465                 470                 475                 480 

Glu Glu Ala Ala Leu Gln His Ser Ala Val Val Met Ala Ala Ala Val 
                485                 490                 495     

Gly Thr Pro Asp Pro Val Arg Gly Glu Val Val Lys Leu Phe Val Lys 
            500                 505                 510         

Leu Arg Glu Gly Val Pro Ala Asn Glu Cys Leu Thr Ala Glu Leu Gln 
        515                 520                 525             

Asn Trp Val Lys Glu Arg Val Gly Ala His Ser Tyr Pro Arg Glu Ile 
    530                 535                 540                 

Glu Phe Val Asp Glu Leu Pro Leu Thr Pro Ser Gly Lys Val Arg Arg 
545                 550                 555                 560 

Arg Ala Leu Arg Glu Arg Glu Tyr Ala Gln Lys Gly Val Pro Leu Pro 
                565                 570                 575     

Gly Lys Arg Gly 
            580 

<210>   1337
<211>   580
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1327

<400>   1337
Met Pro Cys His Arg Glu Met Lys Gly Ala Ile Glu His Glu Glu Val 
                5                   10                  15      

Val Leu Met Asp Asp Leu Trp Thr Val Asp Gly Asp Asp Leu Arg Lys 
            20                  25                  30          

Leu Pro Tyr Gly Ala Met Tyr Ala Lys Phe Arg Trp Pro Thr Pro Asp 
        35                  40                  45              

Arg Leu Asn Ile Ala Glu Trp Ala Cys Arg Arg His Ala Arg Val Cys 
    50                  55                  60                  

Pro Asp Ala Pro Ala Ile Trp Tyr Asp Val Asp Gly Gly Ser Ala Glu 
65                  70                  75                  80  

Met Trp Thr Phe Gly His Leu Trp Arg Thr Thr Ser Arg Leu Ala Trp 
                85                  90                  95      

Ala Leu Leu Arg Gly Leu Gly Val Pro Thr Gly Gly Arg Val Ala Ile 
            100                 105                 110         

Leu Leu Pro Gln Ser Pro Gln Leu Ala Ala Ala His Leu Ala Ser Tyr 
        115                 120                 125             

Ala Ile Gly Ala Ile Ala Val Pro Leu Phe Thr Leu Phe Gly Thr Asp 
    130                 135                 140                 

Ala Leu Arg Tyr Arg Leu Gln Asp Ser Gly Ala Thr Val Val Val Thr 
145                 150                 155                 160 

Asp Ser Glu Gln Ala Asn Arg Ile Met Asp Ile Arg Ala Asp Leu Pro 
                165                 170                 175     

Asp Leu Glu His Val Ile Val Thr Asp Ala Arg Val Pro Gly Thr Gln 
            180                 185                 190         

Phe Trp Asp Asp Val Leu Ala Leu Ala Ser Ser Ala Glu Tyr His Pro 
        195                 200                 205             

Met Asp Ala Ser Pro Asp Asp Pro Ala Val Leu Ile Tyr Thr Ser Gly 
    210                 215                 220                 

Thr Thr Gly Ser Ala Lys Gly Ala Leu His Gly His Arg Ile Leu Leu 
225                 230                 235                 240 

Gly His Leu Pro Gly Val Ser Leu Pro His Asp Phe Ala Pro Gln Pro 
                245                 250                 255     

Gly Asp Val Phe Trp Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu 
            260                 265                 270         

Tyr Asp Val Leu Leu Pro Ala Leu Cys Trp Gly Val Pro Val Val Ala 
        275                 280                 285             

His Arg Ile Arg Lys Phe Asp Pro Glu Arg Ala Phe Ala Leu Met Glu 
    290                 295                 300                 

Arg Trp Arg Val Arg Asn Ala Phe Met Pro Pro Thr Ser Leu Lys Met 
305                 310                 315                 320 

Met Arg His Ile Thr Asp Pro Arg Ser Arg Trp His Leu His Leu Arg 
                325                 330                 335     

Thr Leu Ala Thr Gly Gly Glu Pro Leu Gly Ala Glu Leu Leu Ser Trp 
            340                 345                 350         

Ala Arg Glu Ala Leu Gly Leu Ser Ile His Glu Phe Tyr Gly Gln Thr 
        355                 360                 365             

Glu Cys Asn Leu Val Val Ala Asn Cys Ser Ala Cys Phe Gln Pro Lys 
    370                 375                 380                 

Pro Gly Ser Met Gly Arg Pro Val Pro Gly His Asp Val Ala Val Ile 
385                 390                 395                 400 

Asp Glu Asn Gly His Val Val Ser Pro Gly Val Ile Gly Glu Ile Ala 
                405                 410                 415     

Val Arg Arg Pro His Pro Val Met Phe Ile Gly Tyr Trp Asn Arg Pro 
            420                 425                 430         

Glu Glu Thr Ala Ala Lys Phe Val Gly Asp Trp Leu Lys Thr Gly Asp 
        435                 440                 445             

Leu Gly Arg Met Asp Glu Glu Gly Tyr Leu Trp Phe Val Gly Arg Ala 
    450                 455                 460                 

Asp Asp Val Ile Thr Ser Ala Gly Tyr Arg Ile Gly Pro Val Glu Ile 
465                 470                 475                 480 

Glu Glu Ala Ala Leu Gln His Ser Ala Val Val Met Ala Ala Ala Val 
                485                 490                 495     

Gly Thr Pro Asp Pro Val Arg Gly Glu Val Val Lys Leu Phe Val Lys 
            500                 505                 510         

Leu Arg Asp Gly Val Pro Ala Asn Glu Cys Leu Thr Ala Glu Leu Gln 
        515                 520                 525             

Asn Trp Val Lys Glu Arg Val Gly Ala His Ser Tyr Pro Arg Glu Ile 
    530                 535                 540                 

Glu Phe Val Asp Glu Leu Pro Leu Thr Pro Ser Gly Lys Val Arg Arg 
545                 550                 555                 560 

Arg Ala Leu Arg Glu Arg Glu Tyr Ala Gln Lys Gly Val Pro Leu Pro 
                565                 570                 575     

Gly Lys Arg Gly 
            580 

<210>   1338
<211>   580
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1327

<400>   1338
Met Pro Cys His Arg Glu Met Lys Gly Ala Ile Glu His Glu Glu Val 
                5                   10                  15      

Val Leu Met Asp Asp Leu Trp Thr Val Asp Gly Asp Asp Leu Arg Lys 
            20                  25                  30          

Leu Pro Tyr Gly Ala Met Tyr Ala Lys Phe Arg Trp Pro Thr Pro Asp 
        35                  40                  45              

Arg Leu Asn Ile Ala Glu Trp Ala Cys Arg Arg His Ala Arg Val Cys 
    50                  55                  60                  

Pro Asp Ala Pro Ala Ile Trp Tyr Asp Val Asp Gly Gly Ser Ala Glu 
65                  70                  75                  80  

Met Trp Thr Phe Gly His Leu Trp Arg Thr Thr Ser Arg Leu Ala Trp 
                85                  90                  95      

Ala Leu Leu Arg Gly Leu Gly Val Pro Thr Gly Gly Arg Val Ala Ile 
            100                 105                 110         

Leu Leu Pro Gln Ser Pro Gln Leu Ala Ala Ala His Leu Ala Ser Tyr 
        115                 120                 125             

Ala Ile Gly Ala Ile Ala Val Pro Leu Phe Thr Leu Phe Gly Thr Asp 
    130                 135                 140                 

Ala Leu Arg Tyr Arg Leu Gln Asp Ser Gly Ala Thr Val Val Val Thr 
145                 150                 155                 160 

Asp Ser Glu Gln Ala Asn Arg Ile Met Asp Ile Arg Ala Asp Leu Pro 
                165                 170                 175     

Asp Leu Glu His Val Ile Val Thr Asp Ala Arg Val Pro Gly Thr Gln 
            180                 185                 190         

Phe Trp Asp Asp Val Leu Ala Leu Ala Ser Ser Ala Glu Tyr His Pro 
        195                 200                 205             

Met Asp Ala Ser Pro Asp Asp Pro Ala Val Leu Ile Tyr Thr Ser Gly 
    210                 215                 220                 

Thr Thr Gly Ser Ala Lys Gly Ala Leu His Gly His Arg Ile Leu Leu 
225                 230                 235                 240 

Gly His Leu Pro Gly Val Ser Leu Pro His Asp Phe Ala Pro Gln Pro 
                245                 250                 255     

Gly Asp Val Phe Trp Thr Pro Ala Asp Trp Ala Trp Ile Gly Gly Leu 
            260                 265                 270         

Tyr Asp Val Ile Leu Pro Ala Leu Cys Trp Gly Val Pro Val Val Ala 
        275                 280                 285             

His Arg Ile Arg Lys Phe Asp Pro Glu Arg Ala Phe Ala Leu Met Glu 
    290                 295                 300                 

Arg Trp Arg Val Arg Asn Ala Phe Met Pro Pro Thr Ser Leu Lys Met 
305                 310                 315                 320 

Met Arg His Ile Thr Asp Pro Arg Ser Arg Trp His Leu His Leu Arg 
                325                 330                 335     

Thr Leu Ala Thr Gly Gly Glu Pro Leu Gly Ala Glu Leu Leu Ser Trp 
            340                 345                 350         

Ala Arg Glu Ala Leu Gly Leu Ser Ile His Glu Phe Tyr Gly Gln Thr 
        355                 360                 365             

Glu Cys Asn Leu Val Val Ala Asn Cys Ser Ala Cys Phe Gln Pro Lys 
    370                 375                 380                 

Pro Gly Ser Met Gly Arg Pro Val Pro Gly His Asp Val Ala Val Ile 
385                 390                 395                 400 

Asp Glu Asn Gly His Val Val Ser Pro Gly Val Ile Gly Glu Ile Ala 
                405                 410                 415     

Val Arg Arg Pro His Pro Val Met Phe Ile Gly Tyr Trp Asn Arg Pro 
            420                 425                 430         

Glu Glu Thr Ala Ala Lys Phe Val Gly Asp Trp Leu Lys Thr Gly Asp 
        435                 440                 445             

Leu Gly Arg Met Asp Glu Glu Gly Tyr Leu Trp Phe Val Gly Arg Ala 
    450                 455                 460                 

Asp Asp Val Ile Thr Ser Ala Gly Tyr Arg Ile Gly Pro Val Glu Ile 
465                 470                 475                 480 

Glu Glu Ala Ala Leu Gln His Ser Ala Val Val Met Ala Ala Ala Val 
                485                 490                 495     

Gly Thr Pro Asp Pro Val Arg Gly Glu Val Val Lys Leu Phe Val Lys 
            500                 505                 510         

Leu Arg Glu Gly Val Pro Ala Asn Glu Cys Leu Thr Ala Glu Leu Gln 
        515                 520                 525             

Asn Trp Val Lys Glu Arg Val Gly Ala His Ser Tyr Pro Arg Glu Ile 
    530                 535                 540                 

Glu Phe Val Asp Glu Leu Pro Leu Thr Pro Ser Gly Lys Val Arg Arg 
545                 550                 555                 560 

Arg Ala Leu Arg Glu Arg Glu Tyr Ala Gln Lys Gly Val Pro Leu Pro 
                565                 570                 575     

Gly Lys Arg Gly 
            580 

<210>   1339
<211>   1743
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1328

<400>   1339
gtgccgtgcc acagggaaat gaaaggcgcg atcgagcatg aggaggtcgt tctcatggac       60

gacctttgga cggtggatgg ggacgatctg cggaagttgc cctacggggc gatgtatgcc      120

aagtttcggt ggcccacgcc ggatcggctg aatatcgccg agtgggcgtg tcgcaggcat      180

gcgcgggtgt gcccggatgc gcccgctatt tggtatgacg tcgacggtgg gtcggcggaa      240

atgtggacct tcggccatct gtggcgcacc acaagcaggt tggcctgggc tcttctgaga      300

ggccttgggg ttccaaccgg gggacgggtg gccatccttc tcccgcagtc tccccagctc      360

gcggcggccc acctcgcctc gtacgctatc ggggcgatcg cggtacccct gttcacgctg      420

ttcggaacgg acgcgcttcg ctaccggctc caggatagcg gcgccacagt cgtggtcacg      480

gacagcgaac aggcgaatcg gatcatggat atcagggccg atcttccaga cctcgagcac      540

gtcatcgtca cagacgcccg cgttccaggc acgcagtttt gggatgatgt cctcgccctc      600

gcgtcgtctg ctgaatacca cccgatggac gcttcgcccg acgatccggc tgtcctcatc      660

tacacctccg gcacaaccgg gtccgcgaag ggggcgcttc acggccatcg catcctgctc      720

ggccacctgc ctggcgtcag tcttccgcac gatttcgcgc cgcagccggg tgacgtcttc      780

tggacgcccg cggattgggc atggattggc gggctgtacg acgtgttgct gccagccctg      840

tgctggggtg tcccggtggt ggcgcatcgc atacgcaagt tcgatcccga acgtgccttc      900

gccctaatgg agcggtggcg cgttcgcaac gccttcatgc ctcccacgtc cctcaagatg      960

atgcgccata tcaccgaccc cagaagccga tggcatctac acctgcgcac gttggcgacg     1020

ggcggcgaac cgctcggcgc ggaacttctc tcgtgggctc gcgaggcgtt aggcctctcg     1080

attcacgagt tctacggcca gacggagtgc aatctggttg tcgccaactg cagcgcatgt     1140

ttccagccga agccgggttc catgggacga ccggtgccag gccacgatgt ggccgtgatc     1200

gacgaaaacg gccacgtgat ttctcctggc gtgatcggcg agatcgccgt tcgccgtccg     1260

catccggtga tgttcatcgg ctattggaac cgccctgagg agaccgccgc gaagttcgtc     1320

ggggactggc tgaagacggg cgatctcggc cgcatggacg aggaaggcta tctgtggttc     1380

gtggggcgcg cggacgacgt catcacgtcg gcgggctacc ggatcggccc ggtggagatc     1440

gaggaggcgg cgcttcaaca ttcggccgtg gtcatggcgg cggccgttgg cacgcccgat     1500

cctgttcgcg gcgaggtggt gaagctcttt gtgaaactcc gtgagggcgt gcccgcgaac     1560

gagtgcctca ccgcggagct tcagaactgg gtcaaggagc gggtgggcgc gcacagctat     1620

ccgcgggaga tcgagttcgt cgacgaactt cccctcacgc cgtcgggcaa ggtgcgccgg     1680

cgagcgctgc gcgaacggga atacgcgcaa aagggcgtcc cgctgcccgg taagcgcggc     1740

tga                                                                   1743


<210>   1340
<211>   1743
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1328

<400>   1340
gtgccgtgcc acagggaaat gaaaggcgcg atcgagcatg aggaggtcgt tctcatggac       60

gaactttgga cggtggatgg ggacgatctg cggaagttgc cctacggggc gatgtatgcc      120

aagtttcggt ggcccacgcc ggatcggctg aatatcgccg agtgggcgtg tcgcaggcat      180

gcgcgggtgt gcccggatgc gcccgctatt tggtatgacg tcgacggtgg gtcggcggaa      240

atgtggacct tcggccatct gtggcgcacc acaagcaggt tggcctgggc tcttctgaga      300

ggccttgggg ttccaaccgg gggacgggtg gccatccttc tcccgcagtc tccccagctc      360

gcggcggccc acctcgcctc gtacgctatc ggggcgatcg cggtacccct gttcacgctg      420

ttcggaacgg acgcgcttcg ctaccggctc caggatagcg gcgccacagt cgtggtcacg      480

gacagcgaac aggcgaatcg gatcatggat atcagggccg atcttccaga cctcgagcac      540

gtcatcgtca cagacgcccg cgttccaggc acgcagtttt gggatgatgt cctcgccctc      600

gcgtcgtctg ctgaatacca cccgatggac gcttcgcccg acgatccggc tgtcctcatc      660

tacacctccg gcacaaccgg gtccgcgaag ggggcgcttc acggccatcg catcctgctc      720

ggccacctgc ctggcgtcag tcttccgcac gatttcgcgc cgcagccggg tgacgtcttc      780

tggacgcccg cggattgggc atggattggc gggctgtacg acgtgttgct gccagccctg      840

tgctggggtg tcccggtggt ggcgcatcgc atacgcaagt tcgatcccga acgtgccttc      900

gccctaatgg agcggtggcg cgttcgcaac gccttcatgc ctcccacgtc cctcaagatg      960

atgcgccata tcaccgaccc cagaagccga tggcatctac acctgcgcac gttggcgacg     1020

ggcggcgaac cgctcggcgc ggaacttctc tcgtgggctc gcgaggcgtt aggcctctcg     1080

attcacgagt tctacggcca gacggagtgc aatctggttg tcgccaactg cagcgcatgt     1140

ttccagccga agccgggttc catgggacga ccggtgccag gccacgatgt ggccgtgatc     1200

gacgaaaacg gccacgtggt atctcctggc gtgatcggcg agatcgccgt tcgccgtccg     1260

catccggtga tgttcatcgg ctattggaac cgccctgagg agaccgccgc gaagttcgtc     1320

ggggactggc tgaagacggg cgatctcggc cgcatggacg aggaaggcta tctgtggttc     1380

gtggggcgcg cggacgacgt catcacgtcg gcgggctacc ggatcggccc ggtggagatc     1440

gaggaggcgg cgcttcaaca ttcggccgtg gtcatggcgg cggccgttgg cacgcccgat     1500

cctgttcgcg gcgaggtggt gaagctcttt gtgaaactcc gtgagggcgt gcccgcgaac     1560

gagtgcctca ccgcggagct tcagaactgg gtcaaggagc gggtgggcgc gcacagctat     1620

ccgcgggaga tcgagttcgt cgacgaactt cccctcacgc cgtcgggcaa ggtgcgccgg     1680

cgagcgctgc gcgaacggga atacgcgcaa aagggcgtcc cgctgcccgg taagcgcggc     1740

tga                                                                   1743


<210>   1341
<211>   1743
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1328

<400>   1341
gtgccgtgcc acagggaaat gaaaggcgcg atcgagcatg aggaggtcgt tctcatggac       60

gacctttgga cggtggatgg ggacgatctg cggaagttgc cctacggggc gatgtatgcc      120

aagtttcggt ggcccacgcc ggatcggctg aatatcgccg agtgggcgtg tcgcaggcat      180

gcgcgggtgt gcccggatgc gcccgctatt tggtatgacg tcgacggtgg gtcggcggaa      240

atgtggacct tcggccatct gtggcgcacc acaagcaggt tggcctgggc tcttctgaga      300

ggccttgggg ttccaaccgg gggacgggtg gccatccttc tcccgcagtc tccccagctc      360

gcggcggccc acctcgcctc gtacgctatc ggggcgatcg cggtacccct gttcacgctg      420

ttcggaacgg acgcgcttcg ctaccggctc caggatagcg gcgccacagt cgtggtcacg      480

gacagcgaac aggcgaatcg gatcatggat atcagggccg atcttccaga cctcgagcac      540

gtcatcgtca cagacgcccg cgttccaggc acgcagtttt gggatgatgt cctcgccctc      600

gcgtcgtctg ctgaatacca cccgatggac gcttcgcccg acgatccggc tgtcctcatc      660

tacacctccg gcacaaccgg gtccgcgaag ggggcgcttc acggccatcg catcctgctc      720

ggccacctgc ctggcgtcag tcttccgcac gatttcgcgc cgcagccggg tgacgtcttc      780

tggacgcccg cggattgggc atggattggc gggctgtacg acgtgttgct gccagccctg      840

tgctggggtg tcccggtggt ggcgcatcgc atacgcaagt tcgatcccga acgtgccttc      900

gccctaatgg agcggtggcg cgttcgcaac gccttcatgc ctcccacgtc cctcaagatg      960

atgcgccata tcaccgaccc cagaagccga tggcatctac acctgcgcac gttggcgacg     1020

ggcggcgaac cgctcggcgc ggaacttctc tcgtgggctc gcgaggcgtt aggcctctcg     1080

attcacgagt tctacggcca gacggagtgc aatctggttg tcgccaactg cagcgcatgt     1140

ttccagccga agccgggttc catgggacga ccggtgccag gccacgatgt ggccgtgatc     1200

gacgaaaacg gccacgtggt atctcctggc gtgatcggcg agatcgccgt tcgccgtccg     1260

catccggtga tgttcatcgg ctattggaac cgccctgagg ataccgccgc gaagttcgtc     1320

ggggactggc tgaagacggg cgatctcggc cgcatggacg aggaaggcta tctgtggttc     1380

gtggggcgcg cggacgacgt catcacgtcg gcgggctacc ggatcggccc ggtggagatc     1440

gaggaggcgg cgcttcaaca ttcggccgtg gtcatggcgg cggccgttgg cacgcccgat     1500

cctgttcgcg gcgaggtggt gaagctcttt gtgaaactcc gtgagggcgt gcccgcgaac     1560

gagtgcctca ccgcggagct tcagaactgg gtcaaggagc gggtgggcgc gcacagctat     1620

ccgcgggaga tcgagttcgt cgacgaactt cccctcacgc cgtcgggcaa ggtgcgccgg     1680

cgagcgctgc gcgaacggga atacgcgcaa aagggcgtcc cgctgcccgg taagcgcggc     1740

tga                                                                   1743


<210>   1342
<211>   1743
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1328

<400>   1342
gtgccgtgcc acagggaaat gaaaggcgcg atcgagcatg aggaggtcgt tctcatggac       60

gacctttgga cggtggatgg ggacgatctg cggaagttgc cctacggggc gatgtatgcc      120

aagtttcggt ggcccacgcc ggatcggctg aatatcgccg agtgggcgtg tcgcaggcat      180

gcgcgggtgt gcccggatgc gcccgctatt tggtatgacg tcgacggtgg gtcggcggaa      240

atgtggacct tcggccatct gtggcgcacc acaagcaggt tggcctgggc tcttctgaga      300

ggccttgggg ttccaaccgg gggacgggtg gccatccttc tcccgcagtc tccccagctc      360

gcggcggccc acctcgcctc gtacgctatc ggggcgatcg cggtacccct gttcacgctg      420

ttcggaacgg acgcgcttcg ctaccggctc caggatagcg gcgccacagt cgtggtcacg      480

gacagcgaac aggcgaatcg gatcatggat atcagggccg atcttccaga cctcgagcac      540

gtcatcgtca cagacgcccg cgttccaggc acgcagtttt gggatgatgt cctcgccctc      600

gcgtcgtctg ctgaatacca cccgatggac gcttcgcccg acgatccggc tgtcctcatc      660

tacacctccg gcacaaccgg gtccgcgaag ggggcgcttc acggccatcg catcctgctc      720

ggccacctgc ctggcgtcag tcttccgcac gatttcgcgc cgcagccggg tgacgtcttc      780

tggacgcccg cggattgggc atggattggc gggctgtacg acgtgttgct gccagccctg      840

tgctggggtg tcccggtggt ggcgcatcgc atacgcaagt tcgatcccga acgtgccttc      900

gccctaatgg agcggtggcg cgttcgcaac gccttcatgc ctcccacgtc cctcaagatg      960

atgcgccata tcaccgaccc cagaagccga tggcatctac acctgcgcac gttggcgacg     1020

ggcggcgaac cgctcggcgc ggaacttctc tcgtgggctc gcgaggcgtt aggcctctcg     1080

attcacgagt tctacggcca gacggagtgc aatctggttg tcgccaactg cagcgcatgt     1140

ttccagccga agccgggttc catgggacga ccggtgccag gccacgatgt ggccgtgatc     1200

gacgaaaacg gccacgtggt atctcctggc gtgatcggcg agatcgccgt tcgccgtccg     1260

catccggtga tgttcatcgg ctattggaac cgccctgagg agaccgccgc gaagttcgtc     1320

ggggactggc tgaagacggg cgatctcggc cgcatggacg aggaaggcta tctgtggttc     1380

gtggggcgcg cggacgacgt catcacgtcg gcgggctacc ggatcggccc ggtggagatc     1440

gaggaggcgg cgcttcaaca ttcggccgtg gtcatggcgg cggccgttgg cacgcccgat     1500

cctgttcgcg gcgaggtggt gaagctcttt gtgaaactcc gtgatggcgt gcccgcgaac     1560

gagtgcctca ccgcggagct tcagaactgg gtcaaggagc gggtgggcgc gcacagctat     1620

ccgcgggaga tcgagttcgt cgacgaactt cccctcacgc cgtcgggcaa ggtgcgccgg     1680

cgagcgctgc gcgaacggga atacgcgcaa aagggcgtcc cgctgcccgg taagcgcggc     1740

tga                                                                   1743


<210>   1343
<211>   1743
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1328

<400>   1343
gtgccgtgcc acagggaaat gaaaggcgcg atcgagcatg aggaggtcgt tctcatggac       60

gacctttgga cggtggatgg ggacgatctg cggaagttgc cctacggggc gatgtatgcc      120

aagtttcggt ggcccacgcc ggatcggctg aatatcgccg agtgggcgtg tcgcaggcat      180

gcgcgggtgt gcccggatgc gcccgctatt tggtatgacg tcgacggtgg gtcggcggaa      240

atgtggacct tcggccatct gtggcgcacc acaagcaggt tggcctgggc tcttctgaga      300

ggccttgggg ttccaaccgg gggacgggtg gccatccttc tcccgcagtc tccccagctc      360

gcggcggccc acctcgcctc gtacgctatc ggggcgatcg cggtacccct gttcacgctg      420

ttcggaacgg acgcgcttcg ctaccggctc caggatagcg gcgccacagt cgtggtcacg      480

gacagcgaac aggcgaatcg gatcatggat atcagggccg atcttccaga cctcgagcac      540

gtcatcgtca cagacgcccg cgttccaggc acgcagtttt gggatgatgt cctcgccctc      600

gcgtcgtctg ctgaatacca cccgatggac gcttcgcccg acgatccggc tgtcctcatc      660

tacacctccg gcacaaccgg gtccgcgaag ggggcgcttc acggccatcg catcctgctc      720

ggccacctgc ctggcgtcag tcttccgcac gatttcgcgc cgcagccggg tgacgtcttc      780

tggacgcccg cggattgggc atggattggc gggctgtacg acgtgattct gccagccctg      840

tgctggggtg tcccggtggt ggcgcatcgc atacgcaagt tcgatcccga acgtgccttc      900

gccctaatgg agcggtggcg cgttcgcaac gccttcatgc ctcccacgtc cctcaagatg      960

atgcgccata tcaccgaccc cagaagccga tggcatctac acctgcgcac gttggcgacg     1020

ggcggcgaac cgctcggcgc ggaacttctc tcgtgggctc gcgaggcgtt aggcctctcg     1080

attcacgagt tctacggcca gacggagtgc aatctggttg tcgccaactg cagcgcatgt     1140

ttccagccga agccgggttc catgggacga ccggtgccag gccacgatgt ggccgtgatc     1200

gacgaaaacg gccacgtggt atctcctggc gtgatcggcg agatcgccgt tcgccgtccg     1260

catccggtga tgttcatcgg ctattggaac cgccctgagg agaccgccgc gaagttcgtc     1320

ggggactggc tgaagacggg cgatctcggc cgcatggacg aggaaggcta tctgtggttc     1380

gtggggcgcg cggacgacgt catcacgtcg gcgggctacc ggatcggccc ggtggagatc     1440

gaggaggcgg cgcttcaaca ttcggccgtg gtcatggcgg cggccgttgg cacgcccgat     1500

cctgttcgcg gcgaggtggt gaagctcttt gtgaaactcc gtgagggcgt gcccgcgaac     1560

gagtgcctca ccgcggagct tcagaactgg gtcaaggagc gggtgggcgc gcacagctat     1620

ccgcgggaga tcgagttcgt cgacgaactt cccctcacgc cgtcgggcaa ggtgcgccgg     1680

cgagcgctgc gcgaacggga atacgcgcaa aagggcgtcc cgctgcccgg taagcgcggc     1740

tga                                                                   1743


<210>   1344
<211>   531
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1344
Met Ala Ala Gln Arg Thr Thr Arg Ser Cys Pro Arg Thr Arg Arg Ser 
                5                   10                  15      

Ser Ser Cys Thr Gly Arg Pro Met Thr Pro Arg Gly Met Gln Arg Arg 
            20                  25                  30          

Trp Asn Arg Leu Gln Asn Glu Gly Glu Gly Lys Met His Arg Thr Ser 
        35                  40                  45              

Ser Val Ser Val Ala Gly His Leu Arg Asn Trp Ile Gly Gly Ala Trp 
    50                  55                  60                  

Arg Asp Ala Glu Ala Ser Glu Tyr Leu Asp Val Phe Asp Pro Ala Thr 
65                  70                  75                  80  

Ala Glu Val Ile Ala Gln Val Pro Leu Ser Thr Gln Gln Asp Val Glu 
                85                  90                  95      

Met Ala Val Ala Ala Ala Ala Glu Ala Phe Arg Glu Trp Ser Lys Thr 
            100                 105                 110         

Pro Val Pro Arg Arg Ala Arg Ile Phe Phe Arg Tyr Gln Gln Leu Leu 
        115                 120                 125             

Val Asp His Trp Asp Glu Leu Ala Arg Leu Ile Val Arg Glu Asn Gly 
    130                 135                 140                 

Lys Ser Tyr Lys Asp Ala Tyr Gly Glu Val Gln Arg Ala Ile Glu Asn 
145                 150                 155                 160 

Val Glu Phe Ala Ala Ser Ala Pro Thr Leu Leu Met Gly Glu Gln Leu 
                165                 170                 175     

Ala Asn Ile Ala Thr Ser Leu Asp Ser Gly Met Tyr Arg Tyr Pro Leu 
            180                 185                 190         

Gly Val Val Ala Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val Pro 
        195                 200                 205             

Cys Trp Met Phe Pro Leu Ala Ile Val Cys Gly Asn Thr Phe Val Leu 
    210                 215                 220                 

Lys Pro Ser Glu Arg Thr Pro Leu Leu Ala Gln Arg Leu Ala Glu Leu 
225                 230                 235                 240 

Leu Glu Glu Ala Gly Leu Pro Ser Gly Val Leu Asn Ile Val His Gly 
                245                 250                 255     

Ala Arg Glu Val Val Gln Gly Leu Ile Glu His Pro Thr Val Arg Ala 
            260                 265                 270         

Ile Ser Phe Val Gly Ser Gln Pro Val Ala Ala Tyr Val Tyr Arg Glu 
        275                 280                 285             

Ala Ala Ala His Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn 
    290                 295                 300                 

His Thr Ile Val Met Pro Asp Ala Asp Leu Asp Glu Ala Ile Pro Gln 
305                 310                 315                 320 

Ile Ile Ser Ala Ala Phe Gly Ser Ala Gly Glu Arg Cys Met Ala Cys 
                325                 330                 335     

Ser Val Val Val Ala Val Gly Ser Ile Ala Asp Arg Leu Val Glu Gly 
            340                 345                 350         

Leu Lys Ser Ala Ala Asp Gln Ile Arg Ile Gly Asn Gly Leu Asp Glu 
        355                 360                 365             

Asp Val Leu Leu Gly Pro Val Ile Arg Ala Glu His Arg Asp Arg Thr 
    370                 375                 380                 

Leu Gln Tyr Ile Asp Leu Gly Ile Gln Glu Gly Ala Val Leu Val Arg 
385                 390                 395                 400 

Asp Gly Arg Gln Asp Arg Val Asp Ala Asn Gly Tyr Phe Val Gly Pro 
                405                 410                 415     

Thr Ile Phe Asp His Val Arg Pro Ser Met Lys Ile Trp Gln Asp Glu 
            420                 425                 430         

Ile Phe Ala Pro Val Leu Ser Val Val Arg Val Gly Thr Leu Asp Glu 
        435                 440                 445             

Ala Ile Ala Leu Ala Asn Arg Ser Arg Phe Ala Asn Gly Ala Cys Ile 
    450                 455                 460                 

Phe Thr Asn Ser Ala Ser Ala Ile Arg Lys Phe Arg Glu Glu Ile Asp 
465                 470                 475                 480 

Ala Gly Met Leu Gly Val Asn Ile Gly Val Pro Ala Pro Met Ala Phe 
                485                 490                 495     

Phe Pro Phe Ser Gly Trp Lys Asp Ser Phe Tyr Gly Asp Leu His Ala 
            500                 505                 510         

Asn Gly Lys Asp Gly Val Ala Phe Tyr Thr Arg Arg Lys Met Ile Thr 
        515                 520                 525             

Ala Arg Val 
    530     

<210>   1345
<211>   1596
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1345
gtggcagccc agcgaaccac ccggtcgtgc cctcgcacga ggagatcgtc cagctgtacc       60

ggcaggccta tgacgccacg tgggatgcag cgccgatgga atcgcttaca aaatgagggg      120

gaagggaaga tgcataggac gtcgtccgtg agtgtagccg ggcacctgcg caattggatc      180

ggcggcgcgt ggcgagacgc ggaagccagc gaatacctcg acgtcttcga tccggcgacc      240

gcggaggtca tcgctcaggt gccgctgtcg acacaacaag acgtggaaat ggctgtggcg      300

gcggctgcgg aagcgtttcg ggaatggagc aagacccctg tacctcgccg cgcgcgaatc      360

ttctttcgct atcagcaact gctcgtcgat cattgggacg aactcgcccg actgatcgtc      420

cgcgagaacg gcaagagcta caaggacgcc tacggggagg tgcagcgcgc gatcgaaaac      480

gtcgagtttg ccgcgagcgc gccgacgctc ctcatgggag aacaattggc caatatcgcg      540

acatccttgg actcgggcat gtaccggtac ccacttggcg tggtggcagg catcacgccg      600

ttcaactttc cgatgatggt cccttgctgg atgtttcctc tggccatcgt ctgcgggaac      660

acgttcgtgt tgaagccttc cgagcggacg ccgcttttgg cccagcggtt ggccgagctg      720

ctcgaggagg cgggcctgcc ctccggggtc ctcaacattg tgcacggcgc ccgagaggtc      780

gttcaaggcc tgatcgaaca tccgacggtt cgcgccatct cgttcgtcgg atcgcagccg      840

gtggccgcgt acgtgtaccg cgaagcggca gcccacggca agcgcgtgca ggcgctggca      900

ggcgccaaga atcacaccat cgtgatgccg gacgcggatc tggacgaagc catcccccag      960

atcatctcgg ccgcgttcgg ctcggcgggc gagcgctgca tggcctgttc cgtcgtcgtg     1020

gcagtaggtt ccatcgcaga tcgcctcgtc gaaggcctga agtccgctgc cgatcagatc     1080

cgcatcggca acggcctaga cgaagatgtc ctgcttggtc ccgtcatccg ggcagaacat     1140

cgagatcgga cgttgcagta catcgatctc ggcatccagg agggcgcggt ccttgtgcgc     1200

gacggacgcc aggatcgcgt ggatgcaaac gggtacttcg tcggacccac gattttcgat     1260

cacgtccgcc cttccatgaa gatctggcaa gacgagatct ttgcgcccgt gctgtcggtc     1320

gtgcgggtgg gcacgctgga cgaggccatc gcgttggcca accggtcccg gtttgcgaac     1380

ggagcctgca tcttcacgaa cagcgcgtcc gccattcgca agttccgcga ggaaatcgac     1440

gcaggaatgc ttggggtcaa catcggtgtt cctgctccca tggcgttctt ccccttctcg     1500

gggtggaagg attccttcta cggcgatctg cacgccaacg gcaaggacgg cgtggcgttt     1560

tacacgcgcc gaaagatgat cacggcaaga gtatga                               1596


<210>   1346
<211>   484
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1346
Ser Ser Val Thr Glu Thr Lys Thr Leu Lys Asn Phe Ile Gly Gly Gln 
                5                   10                  15      

Trp Val Ala Ser Thr Ser Gly Lys Glu Glu Val Val Pro Asn Pro Ala 
            20                  25                  30          

Thr Gly Glu Val Leu Ala Lys Val Pro Leu Ser Ser Arg Glu Glu Leu 
        35                  40                  45              

Asp Ala Ala Val Ala Ala Ala Lys Glu Ala Phe Arg Glu Trp Arg Lys 
    50                  55                  60                  

Val Pro Val Pro Arg Arg Ala Arg Ile Leu Phe Arg Tyr Gln Gln Leu 
65                  70                  75                  80  

Leu Val Glu His Trp Asp Glu Leu Ala Arg Leu Val Thr Leu Glu Asn 
                85                  90                  95      

Gly Lys Val Tyr Glu Asp Ala Tyr Gly Glu Val Gln Arg Gly Ile Glu 
            100                 105                 110         

Cys Val Glu Phe Ala Ala Gly Ile Pro Thr Leu Met Met Gly Gln Gln 
        115                 120                 125             

Leu Pro Asp Ile Ala Thr Asp Ile Glu Ser Gly Met Tyr Arg Tyr Pro 
    130                 135                 140                 

Leu Gly Val Val Ala Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val 
145                 150                 155                 160 

Pro Cys Trp Met Phe Pro Leu Ala Ile Ala Cys Gly Asn Thr Phe Val 
                165                 170                 175     

Leu Lys Pro Ser Glu Arg Thr Pro Met Leu Ala Asn Arg Leu Ala Glu 
            180                 185                 190         

Leu Phe Thr Glu Ala Gly Leu Pro Pro Gly Val Leu Asn Ile Val His 
        195                 200                 205             

Gly Ala His Glu Val Val Gly Gly Ile Leu Glu His Lys Asp Ile Lys 
    210                 215                 220                 

Ala Val Ser Phe Val Gly Ser Gln Pro Val Ala Glu Tyr Val Tyr Lys 
225                 230                 235                 240 

Thr Ala Ala Ala His Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys 
                245                 250                 255     

Asn His Ser Ile Val Met Pro Asp Ala Asp Leu Asp Met Ala Val Thr 
            260                 265                 270         

Asn Ile Ile Asn Ala Ala Phe Gly Ser Ala Gly Glu Arg Cys Met Ala 
        275                 280                 285             

Cys Ser Val Val Val Ala Val Gly Asp Ile Ala Asp Glu Leu Val Arg 
    290                 295                 300                 

Arg Leu Lys Glu Ala Ala Asp Arg Ile Gln Ile Gly Asn Gly Leu Asp 
305                 310                 315                 320 

Lys Gly Val Phe Leu Gly Pro Val Ile Arg Glu Ser His Lys Glu Arg 
                325                 330                 335     

Thr Ile Lys Tyr Ile Glu Ile Gly Glu Lys Glu Gly Ala Leu Leu Val 
            340                 345                 350         

Arg Asp Gly Arg Arg Asp Ser Ala Thr Ser Gly Gln Gly Tyr Phe Ile 
        355                 360                 365             

Gly Pro Thr Ile Phe Asp His Val Lys Pro Gly Met Thr Ile Trp Thr 
    370                 375                 380                 

Asp Glu Ile Phe Ala Pro Val Leu Ser Val Val Arg Ala Arg Asp Leu 
385                 390                 395                 400 

Asp Glu Ala Ile Glu Ile Ala Asn Arg Ser Glu Phe Ala Asn Gly Ala 
                405                 410                 415     

Cys Ile Tyr Thr Asp Ser Ala Lys Ala Ile Arg Gln Phe Arg Glu Glu 
            420                 425                 430         

Ile Asp Ala Gly Met Leu Gly Val Asn Val Ala Val Pro Ala Pro Met 
        435                 440                 445             

Ala Phe Phe Pro Phe Ser Gly Tyr Lys Asn Ser Phe Tyr Gly Asp Leu 
    450                 455                 460                 

His Ala Asn Gly Arg Asp Gly Val Glu Phe Tyr Thr Arg Lys Lys Met 
465                 470                 475                 480 

Val Thr Ala Arg 
                

<210>   1347
<211>   484
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1347
Ser Ser Val Thr Glu Thr Lys Thr Leu Lys Asn Phe Ile Gly Gly Gln 
                5                   10                  15      

Trp Val Ala Ser Thr Ser Gly Lys Glu Glu Ile Val Pro Asn Pro Ala 
            20                  25                  30          

Thr Gly Glu Val Leu Ala Lys Val Pro Ile Ser Ser Arg Glu Glu Leu 
        35                  40                  45              

Asp Ala Ala Val Ala Ala Ala Lys Glu Ala Phe Arg Glu Trp Arg Lys 
    50                  55                  60                  

Val Pro Val Pro Arg Arg Ala Arg Ile Leu Phe Arg Tyr Gln Gln Leu 
65                  70                  75                  80  

Leu Val Glu His Trp Glu Glu Leu Ala Arg Leu Val Thr Leu Glu Asn 
                85                  90                  95      

Gly Lys Val Tyr Glu Asp Ala Tyr Gly Glu Val Gln Arg Gly Ile Glu 
            100                 105                 110         

Cys Val Glu Phe Ala Ala Gly Ile Pro Thr Leu Met Met Gly Gln Gln 
        115                 120                 125             

Leu Pro Asp Ile Ala Thr Gly Ile Glu Ser Gly Met Tyr Arg Tyr Pro 
    130                 135                 140                 

Leu Gly Val Val Ala Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val 
145                 150                 155                 160 

Pro Cys Trp Met Phe Pro Leu Ala Ile Ala Cys Gly Asn Thr Phe Val 
                165                 170                 175     

Leu Lys Pro Ser Glu Arg Thr Pro Leu Leu Ala Asn Arg Leu Ala Glu 
            180                 185                 190         

Leu Phe Thr Glu Ala Gly Leu Pro Ala Gly Val Leu Asn Ile Val His 
        195                 200                 205             

Gly Ala His Glu Val Val Asn Gly Ile Leu Glu His Lys Asp Ile Lys 
    210                 215                 220                 

Ala Val Ser Phe Val Gly Ser Gln Pro Val Ala Glu Tyr Val Tyr Lys 
225                 230                 235                 240 

Thr Ala Ala Ala Tyr Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys 
                245                 250                 255     

Asn His Ser Ile Val Met Pro Asp Ala Asp Leu Asp Met Ala Val Thr 
            260                 265                 270         

Asn Ile Ile Asn Ala Ala Phe Gly Ser Ala Gly Glu Arg Cys Met Ala 
        275                 280                 285             

Cys Ser Val Val Val Ala Val Gly Asp Ile Ala Asp Glu Leu Val Glu 
    290                 295                 300                 

Arg Leu Lys Lys Ala Ala Asp Arg Ile Gln Ile Gly Asn Gly Leu Asp 
305                 310                 315                 320 

Gln Gly Val Phe Leu Gly Pro Val Ile Arg Glu Ser His Lys Glu Arg 
                325                 330                 335     

Thr Ile Lys Tyr Ile Glu Ile Gly Glu Arg Glu Gly Ala Leu Leu Val 
            340                 345                 350         

Arg Asp Gly Arg Arg Asp Ala Ala Thr Ser Gly Lys Gly Tyr Phe Val 
        355                 360                 365             

Gly Pro Thr Ile Phe Asp His Val Lys Pro Gly Met Thr Ile Trp Thr 
    370                 375                 380                 

Asp Glu Ile Phe Ala Pro Val Leu Ser Val Val Arg Ala Arg Asp Leu 
385                 390                 395                 400 

Asp Glu Ala Ile Glu Ile Ala Asn Arg Ser Glu Phe Ala Asn Gly Ala 
                405                 410                 415     

Cys Ile Tyr Thr Asp Ser Ala Lys Ala Ile Arg Gln Phe Arg Glu Glu 
            420                 425                 430         

Ile Asp Ala Gly Met Leu Gly Val Asn Val Ala Val Pro Ala Pro Met 
        435                 440                 445             

Ala Phe Phe Pro Phe Ser Gly Tyr Lys Asn Ser Phe Tyr Gly Asp Leu 
    450                 455                 460                 

His Ala Asn Gly Arg Asp Gly Val Glu Phe Tyr Thr Arg Lys Lys Met 
465                 470                 475                 480 

Val Thr Ala Arg 
                

<210>   1348
<211>   476
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1348
Leu Lys Asn Tyr Ile Gly Gly Gln Trp Val Glu Ser Arg Ser Ala Lys 
                5                   10                  15      

Thr Glu Ala Val Pro Asn Pro Ala Thr Gly Glu Val Leu Ala Tyr Val 
            20                  25                  30          

Pro Ile Ser Thr Arg Glu Asp Leu Asp Arg Ala Val Ala Ala Ala Lys 
        35                  40                  45              

Glu Ala Phe Lys Thr Trp Ser Lys Thr Pro Val Pro Arg Arg Ala Arg 
    50                  55                  60                  

Ile Leu Phe Lys Tyr Gln Gln Leu Leu Val Glu His Trp Glu Glu Leu 
65                  70                  75                  80  

Ala Arg Leu Val Thr Leu Glu Asn Gly Lys Ser Tyr Asn Glu Ala Tyr 
                85                  90                  95      

Gly Glu Ile Gln Arg Gly Ile Glu Cys Val Glu Phe Ala Ala Gly Ala 
            100                 105                 110         

Pro Thr Leu Met Met Gly Arg Gln Leu Pro Ser Ile Ala Thr Gly Ile 
        115                 120                 125             

Glu Ser Gly Met Tyr Arg Tyr Pro Ile Gly Val Val Gly Gly Ile Thr 
    130                 135                 140                 

Pro Phe Asn Phe Pro Met Met Val Pro Cys Trp Met Phe Pro Leu Ala 
145                 150                 155                 160 

Ile Ala Cys Gly Asn Thr Phe Val Leu Lys Pro Ser Glu Arg Thr Pro 
                165                 170                 175     

Met Leu Ala Asn Arg Leu Ala Glu Leu Phe Lys Glu Ala Gly Leu Pro 
            180                 185                 190         

Asp Gly Val Leu Asn Ile Val His Gly Ala His Asp Val Val Asn Gly 
        195                 200                 205             

Leu Leu Glu His Pro Asp Val Lys Ala Ile Ser Phe Val Gly Ser Gln 
    210                 215                 220                 

Pro Val Gly Glu Tyr Val Tyr Lys Thr Ala Ala Ala His Gly Lys Arg 
225                 230                 235                 240 

Val Gln Ala Leu Thr Gly Ala Lys Asn His Ser Ile Val Met Pro Asp 
                245                 250                 255     

Ala Asp Leu Lys Val Ala Val Arg Glu Ile Ile Asn Ala Ala Phe Gly 
            260                 265                 270         

Ser Ala Gly Glu Arg Cys Met Ala Ala Ser Val Val Val Ala Val Gly 
        275                 280                 285             

Asp Ile Ala Asp Glu Leu Val Glu Arg Leu Val Ala Ala Ala Asn Glu 
    290                 295                 300                 

Ile Lys Ile Gly Asn Gly Leu Glu Glu Ser Val Phe Leu Gly Pro Val 
305                 310                 315                 320 

Ile Arg Glu Ala His Lys Gln Arg Thr Val Asn Tyr Ile Glu Leu Gly 
                325                 330                 335     

Glu Lys Glu Gly Ala Ile Leu Val Arg Asp Gly Arg Lys Asp Ala Ala 
            340                 345                 350         

Val Gln Gly Glu Gly Tyr Phe Ile Gly Pro Thr Ile Phe Asp Arg Val 
        355                 360                 365             

Thr Thr Asp Met Thr Ile Trp Lys Asp Glu Ile Phe Ala Pro Val Leu 
    370                 375                 380                 

Ser Ile Val Arg Val Ser Thr Leu Asp Glu Ala Ile Glu Val Ala Asn 
385                 390                 395                 400 

Lys Ser Pro Phe Ala Asn Gly Ala Cys Ile Tyr Thr Arg Asp Gly Gly 
                405                 410                 415     

Asn Val Arg Lys Phe Arg Asp Glu Ile Asp Ala Gly Met Leu Gly Val 
            420                 425                 430         

Asn Leu Gly Val Pro Ala Pro Met Ala Phe Phe Pro Phe Ser Gly Trp 
        435                 440                 445             

Lys Asn Ser Phe Tyr Gly Asp Leu His Ala Asn Gly Met Asp Gly Val 
    450                 455                 460                 

Glu Phe Tyr Thr Arg Lys Lys Met Leu Thr Ala Arg 
465                 470                 475     

<210>   1349
<211>   476
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1349
Leu Lys Asn Tyr Ile Gly Gly Gln Trp Val Glu Ser Arg Ser Gly Lys 
                5                   10                  15      

Thr Glu Ala Val Pro Asn Pro Ala Thr Gly Glu Val Leu Ala Tyr Val 
            20                  25                  30          

Pro Ile Ser Ser Arg Glu Glu Leu Asp Glu Ala Val Arg Ala Ala Lys 
        35                  40                  45              

Glu Ala Phe Lys Thr Trp Arg Lys Thr Pro Val Pro Arg Arg Ala Arg 
    50                  55                  60                  

Ile Leu Phe Lys Tyr Gln Gln Leu Leu Val Glu His Trp Glu Glu Leu 
65                  70                  75                  80  

Ala Arg Leu Val Thr Leu Glu Asn Gly Lys Ser Tyr Asn Glu Ala Tyr 
                85                  90                  95      

Gly Glu Val Gln Arg Gly Ile Glu Cys Val Glu Phe Ala Ala Gly Ala 
            100                 105                 110         

Pro Thr Leu Met Met Gly Arg Gln Leu Pro Asp Ile Ala Thr Gly Ile 
        115                 120                 125             

Glu Ser Gly Met Tyr Arg Tyr Pro Ile Gly Val Val Gly Gly Ile Thr 
    130                 135                 140                 

Pro Phe Asn Phe Pro Met Met Val Pro Cys Trp Met Phe Pro Leu Ala 
145                 150                 155                 160 

Ile Ala Cys Gly Asn Thr Phe Val Leu Lys Pro Ser Glu Arg Thr Pro 
                165                 170                 175     

Met Leu Ala Asn Arg Leu Ala Glu Leu Phe Lys Glu Ala Gly Leu Pro 
            180                 185                 190         

Asp Gly Val Leu Asn Ile Val His Gly Ala His Asp Val Val Asn Gly 
        195                 200                 205             

Leu Leu Glu His Pro Asp Val Lys Ala Ile Ser Phe Val Gly Ser Gln 
    210                 215                 220                 

Pro Val Gly Glu Tyr Val Tyr Lys Thr Ala Ala Ala His Gly Lys Arg 
225                 230                 235                 240 

Val Gln Ala Leu Thr Gly Ala Lys Asn His Ser Ile Val Met Pro Asp 
                245                 250                 255     

Ala Asp Leu Asn Val Ala Val Arg Glu Ile Ile Asn Ala Ala Phe Gly 
            260                 265                 270         

Ser Ala Gly Glu Arg Cys Met Ala Ala Ser Val Val Val Ala Val Gly 
        275                 280                 285             

Glu Ile Ala Asp Glu Leu Val Glu Lys Leu Val Ala Ala Ala Asn Glu 
    290                 295                 300                 

Leu Lys Ile Gly Asn Gly Leu Glu Glu Ser Val Phe Leu Gly Pro Val 
305                 310                 315                 320 

Ile Arg Glu Ala His Lys Gln Arg Thr Val Lys Tyr Ile Glu Leu Gly 
                325                 330                 335     

Glu Lys Glu Gly Ala Ile Leu Val Arg Asp Gly Arg Lys Asp Ala Ala 
            340                 345                 350         

Val Gln Asp Asn Gly Tyr Phe Ile Gly Pro Thr Ile Phe Asp Arg Val 
        355                 360                 365             

Thr Thr Asp Met Thr Ile Trp Lys Asp Glu Ile Phe Ala Pro Val Leu 
    370                 375                 380                 

Ser Ile Val Arg Val Glu Thr Leu Asp Glu Ala Ile Glu Val Ala Asn 
385                 390                 395                 400 

Lys Ser Pro Phe Ala Asn Gly Ala Cys Ile Tyr Thr Arg Asp Gly Gly 
                405                 410                 415     

Asn Val Arg Lys Phe Arg Glu Glu Ile Asp Ala Gly Met Leu Gly Val 
            420                 425                 430         

Asn Leu Gly Val Pro Ala Pro Met Ala Phe Phe Pro Phe Ser Gly Trp 
        435                 440                 445             

Lys Asn Ser Phe Tyr Gly Asp Leu His Ala Asn Gly Met Asp Gly Val 
    450                 455                 460                 

Glu Phe Tyr Thr Arg Lys Lys Met Met Thr Ser Arg 
465                 470                 475     

<210>   1350
<211>   483
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1350
Ala Asn Leu Ala Thr Gly Glu Lys Leu Lys Asn Phe Ile Gly Gly Gln 
                5                   10                  15      

Trp Val Glu Ser Asp Ser Gly Lys Thr Glu Ala Val Pro Asn Pro Ala 
            20                  25                  30          

Thr Gly Glu Ile Leu Ala His Val Pro Ile Ser Asn Arg Glu Asp Leu 
        35                  40                  45              

Asp Arg Ala Val Ser Val Ala Lys Glu Ala Phe Lys Thr Trp Gly Lys 
    50                  55                  60                  

Thr Pro Val Pro Arg Arg Ala Arg Val Leu Phe Lys Tyr Gln Gln Leu 
65                  70                  75                  80  

Leu Val Glu Asn Trp Glu Glu Leu Ala Arg Leu Val Thr Leu Glu Asn 
                85                  90                  95      

Gly Lys Ser Tyr Lys Glu Ala Tyr Gly Glu Val Gln Arg Gly Ile Glu 
            100                 105                 110         

Cys Val Glu Phe Ala Ala Gly Ala Pro Ser Leu Met Met Gly Lys Gln 
        115                 120                 125             

Leu Pro Asp Ile Ala Thr Asn Ile Glu Ser Gly Met Tyr Arg Tyr Pro 
    130                 135                 140                 

Ile Gly Val Val Gly Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val 
145                 150                 155                 160 

Pro Cys Trp Met Phe Pro Leu Ala Ile Ala Cys Gly Asn Thr Phe Val 
                165                 170                 175     

Leu Lys Pro Ser Glu Arg Thr Pro Leu Leu Ala Asn Arg Leu Ala Glu 
            180                 185                 190         

Leu Phe Thr Glu Ala Gly Leu Pro Glu Gly Val Leu Asn Ile Val His 
        195                 200                 205             

Gly Ala His Asp Val Val Asn Gly Leu Leu Glu His Pro Asp Val Lys 
    210                 215                 220                 

Ala Ile Ser Phe Val Gly Ser Gln Pro Val Ala Glu Tyr Val Tyr Lys 
225                 230                 235                 240 

Thr Ala Ser Gln His Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys 
                245                 250                 255     

Asn His Ser Ile Val Met Pro Asp Ala Asp Leu Asp Gly Ala Val Asn 
            260                 265                 270         

Gln Ile Val Asn Ala Ala Tyr Gly Ser Ala Gly Glu Arg Cys Met Ala 
        275                 280                 285             

Ala Ala Val Val Val Ala Val Gly Glu Val Ala Glu Pro Leu Met Glu 
    290                 295                 300                 

Lys Leu Gln Lys Ala Val Asn Glu Ile Thr Ile Gly Asn Gly Leu Asp 
305                 310                 315                 320 

Asp Asp Val Phe Leu Gly Pro Val Ile Arg Glu Ser His Lys Gln Lys 
                325                 330                 335     

Thr Glu Asn Tyr Ile Glu Leu Gly Glu Lys Glu Gly Ala Thr Leu Val 
            340                 345                 350         

Arg Asp Gly Arg Lys Asp Asn Val Ser Lys Asp Gly Tyr Phe Leu Gly 
        355                 360                 365             

Pro Thr Leu Phe Asp Asn Val Thr Thr Glu Met Thr Ile Trp Lys Glu 
    370                 375                 380                 

Glu Ile Phe Ala Pro Val Leu Ser Val Val Arg Val Glu Ser Leu Asp 
385                 390                 395                 400 

Glu Ala Ile Gln Leu Thr Asn Gln Ser Glu Phe Ala Asn Gly Ala Cys 
                405                 410                 415     

Leu Tyr Thr Thr Asn Gly Ser Ser Val Arg Lys Phe Arg Glu Glu Ile 
            420                 425                 430         

Asp Ala Gly Met Leu Gly Ile Asn Leu Gly Val Pro Ala Pro Met Ala 
        435                 440                 445             

Phe Phe Pro Phe Ser Gly Trp Lys Asn Ser Phe Tyr Gly Asp Leu His 
    450                 455                 460                 

Ala Asn Gly Thr Asp Gly Val Glu Phe Tyr Thr Arg Lys Lys Met Ile 
465                 470                 475                 480 

Thr Ala Arg 
            

<210>   1351
<211>   531
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1344

<400>   1351
Met Ala Ala Gln Arg Thr Thr Arg Ser Cys Pro Arg Thr Arg Arg Ser 
                5                   10                  15      

Ser Ser Cys Thr Gly Arg Pro Met Thr Pro Arg Gly Met Gln Arg Arg 
            20                  25                  30          

Trp Asn Arg Leu Gln Asn Glu Gly Glu Gly Lys Met His Arg Thr Ser 
        35                  40                  45              

Ser Val Ser Val Ala Gly His Leu Arg Asn Trp Ile Gly Gly Ala Trp 
    50                  55                  60                  

Arg Glu Ala Glu Ala Ser Glu Tyr Leu Asp Val Phe Asp Pro Ala Thr 
65                  70                  75                  80  

Ala Glu Val Ile Ala Gln Val Pro Leu Ser Thr Gln Gln Asp Val Glu 
                85                  90                  95      

Met Ala Val Ala Ala Ala Ala Glu Ala Phe Arg Glu Trp Ser Lys Thr 
            100                 105                 110         

Pro Val Pro Arg Arg Ala Arg Ile Phe Phe Arg Tyr Gln Gln Leu Leu 
        115                 120                 125             

Val Asp His Trp Asp Glu Leu Ala Arg Leu Ile Val Arg Glu Asn Gly 
    130                 135                 140                 

Lys Ser Tyr Lys Asp Ala Tyr Gly Glu Val Gln Arg Ala Ile Glu Asn 
145                 150                 155                 160 

Val Glu Phe Ala Ala Ser Ala Pro Thr Leu Leu Met Gly Glu Gln Leu 
                165                 170                 175     

Ala Asn Ile Ala Thr Ser Leu Asp Ser Gly Met Tyr Arg Tyr Pro Leu 
            180                 185                 190         

Gly Val Val Ala Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val Pro 
        195                 200                 205             

Cys Trp Met Phe Pro Leu Ala Ile Val Cys Gly Asn Thr Phe Val Leu 
    210                 215                 220                 

Lys Pro Ser Glu Arg Thr Pro Leu Leu Ala Gln Arg Leu Ala Glu Leu 
225                 230                 235                 240 

Leu Glu Glu Ala Gly Leu Pro Ser Gly Val Leu Asn Ile Val His Gly 
                245                 250                 255     

Ala Arg Glu Val Val Gln Gly Leu Ile Glu His Pro Thr Val Arg Ala 
            260                 265                 270         

Ile Ser Phe Val Gly Ser Gln Pro Val Ala Ala Tyr Val Tyr Arg Glu 
        275                 280                 285             

Ala Ala Ala His Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn 
    290                 295                 300                 

His Thr Ile Val Met Pro Asp Ala Asp Leu Asp Glu Ala Ile Pro Gln 
305                 310                 315                 320 

Ile Ile Ser Ala Ala Phe Gly Ser Ala Gly Glu Arg Cys Met Ala Cys 
                325                 330                 335     

Ser Val Val Val Ala Val Gly Ser Ile Ala Asp Arg Leu Val Glu Gly 
            340                 345                 350         

Leu Lys Ser Ala Ala Asp Gln Ile Arg Ile Gly Asn Gly Leu Asp Glu 
        355                 360                 365             

Asp Val Leu Leu Gly Pro Val Ile Arg Ala Glu His Arg Asp Arg Thr 
    370                 375                 380                 

Leu Gln Tyr Ile Asp Leu Gly Ile Gln Glu Gly Ala Val Leu Val Arg 
385                 390                 395                 400 

Asp Gly Arg Gln Asp Arg Val Asp Ala Asn Gly Tyr Phe Val Gly Pro 
                405                 410                 415     

Thr Ile Phe Asp His Val Arg Pro Ser Met Lys Ile Trp Gln Asp Glu 
            420                 425                 430         

Ile Phe Ala Pro Val Leu Ser Val Val Arg Val Gly Thr Leu Asp Glu 
        435                 440                 445             

Ala Ile Ala Leu Ala Asn Arg Ser Arg Phe Ala Asn Gly Ala Cys Ile 
    450                 455                 460                 

Phe Thr Asn Ser Ala Ser Ala Ile Arg Lys Phe Arg Glu Glu Ile Asp 
465                 470                 475                 480 

Ala Gly Met Leu Gly Val Asn Ile Gly Val Pro Ala Pro Met Ala Phe 
                485                 490                 495     

Phe Pro Phe Ser Gly Trp Lys Asp Ser Phe Tyr Gly Asp Leu His Ala 
            500                 505                 510         

Asn Gly Lys Asp Gly Val Ala Phe Tyr Thr Arg Arg Lys Met Ile Thr 
        515                 520                 525             

Ala Arg Val 
    530     

<210>   1352
<211>   531
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1344

<400>   1352
Met Ala Ala Gln Arg Thr Thr Arg Ser Cys Pro Arg Thr Arg Arg Ser 
                5                   10                  15      

Ser Ser Cys Thr Gly Arg Pro Met Thr Pro Arg Gly Met Gln Arg Arg 
            20                  25                  30          

Trp Asn Arg Leu Gln Asn Glu Gly Glu Gly Lys Met His Arg Thr Ser 
        35                  40                  45              

Ser Val Ser Val Ala Gly His Leu Arg Asn Trp Ile Gly Gly Ala Trp 
    50                  55                  60                  

Arg Asp Ala Glu Ala Ser Glu Tyr Leu Asp Val Phe Asp Pro Ala Thr 
65                  70                  75                  80  

Ala Glu Val Ile Ala Gln Val Pro Leu Ser Thr Gln Gln Asp Val Glu 
                85                  90                  95      

Met Ala Val Ala Ala Ala Ala Glu Ala Phe Arg Glu Trp Ser Lys Thr 
            100                 105                 110         

Pro Val Pro Arg Arg Ala Arg Ile Phe Phe Arg Tyr Gln Gln Leu Leu 
        115                 120                 125             

Val Asp His Trp Asp Glu Leu Ala Arg Leu Ile Val Arg Glu Asn Gly 
    130                 135                 140                 

Lys Ser Tyr Lys Asp Ala Tyr Gly Glu Val Gln Arg Ala Ile Glu Asn 
145                 150                 155                 160 

Val Glu Phe Ala Ala Ser Ala Pro Thr Leu Leu Met Gly Glu Gln Leu 
                165                 170                 175     

Ala Asn Ile Ala Thr Ser Leu Asp Ser Gly Met Tyr Arg Tyr Pro Leu 
            180                 185                 190         

Gly Val Val Ala Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val Pro 
        195                 200                 205             

Cys Trp Met Phe Pro Leu Ala Ile Val Cys Gly Asn Thr Phe Val Leu 
    210                 215                 220                 

Lys Pro Ser Glu Arg Thr Pro Leu Leu Ala Gln Arg Leu Ala Glu Leu 
225                 230                 235                 240 

Leu Glu Glu Ala Gly Leu Pro Ser Gly Val Leu Asn Ile Val His Gly 
                245                 250                 255     

Ala Arg Glu Val Val Asn Gly Leu Ile Glu His Pro Thr Val Arg Ala 
            260                 265                 270         

Ile Ser Phe Val Gly Ser Gln Pro Val Ala Ala Tyr Val Tyr Arg Glu 
        275                 280                 285             

Ala Ala Ala His Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn 
    290                 295                 300                 

His Thr Ile Val Met Pro Asp Ala Asp Leu Asp Glu Ala Ile Pro Gln 
305                 310                 315                 320 

Ile Ile Ser Ala Ala Phe Gly Ser Ala Gly Glu Arg Cys Met Ala Cys 
                325                 330                 335     

Ser Val Val Val Ala Val Gly Ser Ile Ala Asp Arg Leu Val Glu Gly 
            340                 345                 350         

Leu Lys Ser Ala Ala Asp Gln Ile Arg Ile Gly Asn Gly Leu Asp Glu 
        355                 360                 365             

Asp Val Leu Leu Gly Pro Val Ile Arg Ala Glu His Arg Asp Arg Thr 
    370                 375                 380                 

Leu Gln Tyr Ile Asp Leu Gly Ile Gln Glu Gly Ala Val Leu Val Arg 
385                 390                 395                 400 

Asp Gly Arg Gln Asp Arg Val Asp Ala Asn Gly Tyr Phe Val Gly Pro 
                405                 410                 415     

Thr Ile Phe Asp His Val Arg Pro Ser Met Lys Ile Trp Gln Asp Glu 
            420                 425                 430         

Ile Phe Ala Pro Val Leu Ser Val Val Arg Val Gly Thr Leu Asp Glu 
        435                 440                 445             

Ala Ile Ala Leu Ala Asn Arg Ser Arg Phe Ala Asn Gly Ala Cys Ile 
    450                 455                 460                 

Phe Thr Asn Ser Ala Ser Ala Ile Arg Lys Phe Arg Glu Glu Ile Asp 
465                 470                 475                 480 

Ala Gly Met Leu Gly Val Asn Ile Gly Val Pro Ala Pro Met Ala Phe 
                485                 490                 495     

Phe Pro Phe Ser Gly Trp Lys Asp Ser Phe Tyr Gly Asp Leu His Ala 
            500                 505                 510         

Asn Gly Lys Asp Gly Val Ala Phe Tyr Thr Arg Arg Lys Met Ile Thr 
        515                 520                 525             

Ala Arg Val 
    530     

<210>   1353
<211>   531
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1344

<400>   1353
Met Ala Ala Gln Arg Thr Thr Arg Ser Cys Pro Arg Thr Arg Arg Ser 
                5                   10                  15      

Ser Ser Cys Thr Gly Arg Pro Met Thr Pro Arg Gly Met Gln Arg Arg 
            20                  25                  30          

Trp Asn Arg Leu Gln Asn Glu Gly Glu Gly Lys Met His Arg Thr Ser 
        35                  40                  45              

Ser Val Ser Val Ala Gly His Leu Arg Asn Trp Ile Gly Gly Ala Trp 
    50                  55                  60                  

Arg Asp Ala Glu Ala Ser Glu Tyr Leu Asp Val Phe Asp Pro Ala Thr 
65                  70                  75                  80  

Ala Glu Val Ile Ala Gln Val Pro Leu Ser Thr Gln Gln Asp Val Glu 
                85                  90                  95      

Met Ala Val Ala Ala Ala Ala Glu Ala Phe Arg Glu Trp Ser Lys Thr 
            100                 105                 110         

Pro Val Pro Arg Arg Ala Arg Ile Phe Phe Arg Tyr Gln Gln Leu Leu 
        115                 120                 125             

Val Asp His Trp Asp Glu Leu Ala Arg Leu Ile Val Arg Glu Asn Gly 
    130                 135                 140                 

Lys Ser Tyr Lys Asp Ala Tyr Gly Glu Val Gln Arg Ala Ile Glu Asn 
145                 150                 155                 160 

Val Glu Phe Ala Ala Ser Ala Pro Thr Leu Leu Met Gly Glu Gln Leu 
                165                 170                 175     

Ala Asn Ile Ala Thr Ser Leu Asp Ser Gly Met Tyr Arg Tyr Pro Leu 
            180                 185                 190         

Gly Val Val Ala Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val Pro 
        195                 200                 205             

Cys Trp Met Phe Pro Leu Ala Ile Val Cys Gly Asn Thr Phe Val Leu 
    210                 215                 220                 

Lys Pro Ser Glu Arg Thr Pro Leu Leu Ala Gln Arg Leu Ala Glu Leu 
225                 230                 235                 240 

Leu Glu Glu Ala Gly Leu Pro Ser Gly Val Leu Asn Ile Val His Gly 
                245                 250                 255     

Ala Arg Glu Val Val Gln Gly Leu Ile Glu His Pro Thr Val Arg Ala 
            260                 265                 270         

Ile Ser Phe Val Gly Ser Gln Pro Val Ala Ala Tyr Val Tyr Arg Glu 
        275                 280                 285             

Ala Ala Ala His Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn 
    290                 295                 300                 

His Thr Ile Val Met Pro Asp Ala Asp Leu Asp Glu Ala Ile Pro Gln 
305                 310                 315                 320 

Ile Ile Ser Ala Ala Phe Gly Ser Ala Gly Glu Arg Cys Met Ala Cys 
                325                 330                 335     

Ser Val Val Val Ala Val Gly Ser Ile Ala Asp Arg Leu Val Glu Gly 
            340                 345                 350         

Leu Lys Ser Ala Ala Asp Gln Ile Lys Ile Gly Asn Gly Leu Asp Glu 
        355                 360                 365             

Asp Val Leu Leu Gly Pro Val Ile Arg Ala Glu His Arg Asp Arg Thr 
    370                 375                 380                 

Leu Gln Tyr Ile Asp Leu Gly Ile Gln Glu Gly Ala Val Leu Val Arg 
385                 390                 395                 400 

Asp Gly Arg Gln Asp Arg Val Asp Ala Asn Gly Tyr Phe Val Gly Pro 
                405                 410                 415     

Thr Ile Phe Asp His Val Arg Pro Ser Met Lys Ile Trp Gln Asp Glu 
            420                 425                 430         

Ile Phe Ala Pro Val Leu Ser Val Val Arg Val Gly Thr Leu Asp Glu 
        435                 440                 445             

Ala Ile Ala Leu Ala Asn Arg Ser Arg Phe Ala Asn Gly Ala Cys Ile 
    450                 455                 460                 

Phe Thr Asn Ser Ala Ser Ala Ile Arg Lys Phe Arg Glu Glu Ile Asp 
465                 470                 475                 480 

Ala Gly Met Leu Gly Val Asn Ile Gly Val Pro Ala Pro Met Ala Phe 
                485                 490                 495     

Phe Pro Phe Ser Gly Trp Lys Asp Ser Phe Tyr Gly Asp Leu His Ala 
            500                 505                 510         

Asn Gly Lys Asp Gly Val Ala Phe Tyr Thr Arg Arg Lys Met Ile Thr 
        515                 520                 525             

Ala Arg Val 
    530     

<210>   1354
<211>   531
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1344

<400>   1354
Met Ala Ala Gln Arg Thr Thr Arg Ser Cys Pro Arg Thr Arg Arg Ser 
                5                   10                  15      

Ser Ser Cys Thr Gly Arg Pro Met Thr Pro Arg Gly Met Gln Arg Arg 
            20                  25                  30          

Trp Asn Arg Leu Gln Asn Glu Gly Glu Gly Lys Met His Arg Thr Ser 
        35                  40                  45              

Ser Val Ser Val Ala Gly His Leu Arg Asn Trp Ile Gly Gly Ala Trp 
    50                  55                  60                  

Arg Asp Ala Glu Ala Ser Glu Tyr Leu Asp Val Phe Asp Pro Ala Thr 
65                  70                  75                  80  

Ala Glu Val Ile Ala Gln Val Pro Leu Ser Thr Gln Gln Asp Val Glu 
                85                  90                  95      

Met Ala Val Ala Ala Ala Ala Glu Ala Phe Arg Glu Trp Ser Lys Thr 
            100                 105                 110         

Pro Val Pro Arg Arg Ala Arg Ile Phe Phe Arg Tyr Gln Gln Leu Leu 
        115                 120                 125             

Val Asp His Trp Asp Glu Leu Ala Arg Leu Ile Val Arg Glu Asn Gly 
    130                 135                 140                 

Lys Ser Tyr Lys Asp Ala Tyr Gly Glu Val Gln Arg Ala Ile Glu Asn 
145                 150                 155                 160 

Val Glu Phe Ala Ala Ser Ala Pro Thr Leu Leu Met Gly Glu Gln Leu 
                165                 170                 175     

Ala Asn Ile Ala Thr Ser Leu Asp Ser Gly Met Tyr Arg Tyr Pro Leu 
            180                 185                 190         

Gly Val Val Ala Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val Pro 
        195                 200                 205             

Cys Trp Met Phe Pro Leu Ala Ile Val Cys Gly Asn Thr Phe Val Leu 
    210                 215                 220                 

Lys Pro Ser Glu Arg Thr Pro Leu Leu Ala Gln Arg Leu Ala Glu Leu 
225                 230                 235                 240 

Leu Glu Glu Ala Gly Leu Pro Ser Gly Val Leu Asn Ile Val His Gly 
                245                 250                 255     

Ala Arg Glu Val Val Gln Gly Leu Ile Glu His Pro Thr Val Arg Ala 
            260                 265                 270         

Ile Ser Phe Val Gly Ser Gln Pro Val Ala Ala Tyr Val Tyr Arg Glu 
        275                 280                 285             

Ala Ala Ala His Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn 
    290                 295                 300                 

His Thr Ile Val Met Pro Asp Ala Asp Leu Asp Glu Ala Ile Pro Gln 
305                 310                 315                 320 

Ile Ile Ser Ala Ala Phe Gly Ser Ala Gly Glu Arg Cys Met Ala Cys 
                325                 330                 335     

Ser Val Val Val Ala Val Gly Ser Ile Ala Asp Arg Leu Val Glu Gly 
            340                 345                 350         

Leu Lys Ser Ala Ala Asp Gln Ile Arg Ile Gly Asn Gly Leu Asp Glu 
        355                 360                 365             

Asp Val Leu Leu Gly Pro Val Ile Arg Ala Glu His Arg Asp Arg Thr 
    370                 375                 380                 

Leu Gln Tyr Ile Asp Leu Gly Ile Gln Glu Gly Ala Val Leu Val Arg 
385                 390                 395                 400 

Asp Gly Arg Gln Asp Arg Val Asp Ala Asn Gly Tyr Phe Val Gly Pro 
                405                 410                 415     

Thr Ile Phe Asp His Val Arg Pro Ser Met Lys Ile Trp Gln Asp Glu 
            420                 425                 430         

Ile Phe Ala Pro Val Leu Ser Val Val Arg Val Gly Thr Leu Asp Glu 
        435                 440                 445             

Ala Ile Ala Leu Ala Asn Arg Ser Arg Phe Ala Asn Gly Ala Cys Ile 
    450                 455                 460                 

Phe Thr Asn Ser Ala Ser Ala Ile Arg Lys Phe Arg Glu Glu Ile Asp 
465                 470                 475                 480 

Ala Gly Met Leu Gly Val Asn Ile Gly Val Pro Ala Pro Met Ala Phe 
                485                 490                 495     

Phe Pro Phe Ser Gly Trp Lys Asp Ser Phe Tyr Gly Asp Leu His Ala 
            500                 505                 510         

Asn Gly Lys Asp Gly Val Ala Phe Tyr Thr Arg Arg Lys Met Ile Thr 
        515                 520                 525             

Ala Arg Ile 
    530     

<210>   1355
<211>   531
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1344

<400>   1355
Met Ala Ala Gln Arg Thr Thr Lys Ser Cys Pro Arg Thr Arg Arg Ser 
                5                   10                  15      

Ser Ser Cys Thr Gly Arg Pro Met Thr Pro Arg Gly Met Gln Arg Arg 
            20                  25                  30          

Trp Asn Arg Leu Gln Asn Glu Gly Glu Gly Lys Met His Arg Thr Ser 
        35                  40                  45              

Ser Val Ser Val Ala Gly His Leu Arg Asn Trp Ile Gly Gly Ala Trp 
    50                  55                  60                  

Arg Asp Ala Glu Ala Ser Glu Tyr Leu Asp Val Phe Asp Pro Ala Thr 
65                  70                  75                  80  

Ala Glu Val Ile Ala Gln Val Pro Leu Ser Thr Gln Gln Asp Val Glu 
                85                  90                  95      

Met Ala Val Ala Ala Ala Ala Glu Ala Phe Arg Glu Trp Ser Lys Thr 
            100                 105                 110         

Pro Val Pro Arg Arg Ala Arg Ile Phe Phe Arg Tyr Gln Gln Leu Leu 
        115                 120                 125             

Val Asp His Trp Asp Glu Leu Ala Arg Leu Ile Val Arg Glu Asn Gly 
    130                 135                 140                 

Lys Ser Tyr Lys Asp Ala Tyr Gly Glu Val Gln Arg Ala Ile Glu Asn 
145                 150                 155                 160 

Val Glu Phe Ala Ala Ser Ala Pro Thr Leu Leu Met Gly Glu Gln Leu 
                165                 170                 175     

Ala Asn Ile Ala Thr Ser Leu Asp Ser Gly Met Tyr Arg Tyr Pro Leu 
            180                 185                 190         

Gly Val Val Ala Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val Pro 
        195                 200                 205             

Cys Trp Met Phe Pro Leu Ala Ile Val Cys Gly Asn Thr Phe Val Leu 
    210                 215                 220                 

Lys Pro Ser Glu Arg Thr Pro Leu Leu Ala Gln Arg Leu Ala Glu Leu 
225                 230                 235                 240 

Leu Glu Glu Ala Gly Leu Pro Ser Gly Val Leu Asn Ile Val His Gly 
                245                 250                 255     

Ala Arg Glu Val Val Gln Gly Leu Ile Glu His Pro Thr Val Arg Ala 
            260                 265                 270         

Ile Ser Phe Val Gly Ser Gln Pro Val Ala Ala Tyr Val Tyr Arg Glu 
        275                 280                 285             

Ala Ala Ala His Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn 
    290                 295                 300                 

His Thr Ile Val Met Pro Asp Ala Asp Leu Asp Glu Ala Ile Pro Gln 
305                 310                 315                 320 

Ile Ile Ser Ala Ala Phe Gly Ser Ala Gly Glu Arg Cys Met Ala Cys 
                325                 330                 335     

Ser Val Val Val Ala Val Gly Ser Ile Ala Asp Arg Leu Val Glu Gly 
            340                 345                 350         

Leu Lys Ser Ala Ala Asp Gln Ile Arg Ile Gly Asn Gly Leu Asp Glu 
        355                 360                 365             

Asp Val Leu Leu Gly Pro Val Ile Arg Ala Glu His Arg Asp Arg Thr 
    370                 375                 380                 

Leu Gln Tyr Ile Asp Leu Gly Ile Gln Glu Gly Ala Val Leu Val Arg 
385                 390                 395                 400 

Asp Gly Arg Gln Asp Arg Val Asp Ala Asn Gly Tyr Phe Val Gly Pro 
                405                 410                 415     

Thr Ile Phe Asp His Val Arg Pro Ser Met Lys Ile Trp Gln Asp Glu 
            420                 425                 430         

Ile Phe Ala Pro Val Leu Ser Val Val Arg Val Gly Thr Leu Asp Glu 
        435                 440                 445             

Ala Ile Ala Leu Ala Asn Arg Ser Arg Phe Ala Asn Gly Ala Cys Ile 
    450                 455                 460                 

Phe Thr Asn Ser Ala Ser Ala Ile Arg Lys Phe Arg Glu Glu Ile Asp 
465                 470                 475                 480 

Ala Gly Met Leu Gly Val Asn Ile Gly Val Pro Ala Pro Met Ala Phe 
                485                 490                 495     

Phe Pro Phe Ser Gly Trp Lys Asp Ser Phe Tyr Gly Asp Leu His Ala 
            500                 505                 510         

Asn Gly Lys Asp Gly Val Ala Phe Tyr Thr Arg Arg Lys Met Ile Thr 
        515                 520                 525             

Ala Arg Val 
    530     

<210>   1356
<211>   1596
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1345

<400>   1356
gtggcagccc agcgaaccac ccggtcgtgc cctcgcacga ggagatcgtc cagctgtacc       60

ggcaggccta tgacgccacg tgggatgcag cgccgatgga atcgcttaca aaatgagggg      120

gaagggaaga tgcataggac gtcgtccgtg agtgtagccg ggcacctgcg caattggatc      180

ggcggcgcgt ggcgagaagc ggaagccagc gaatacctcg acgtcttcga tccggcgacc      240

gcggaggtca tcgctcaggt gccgctgtcg acacaacaag acgtggaaat ggctgtggcg      300

gcggctgcgg aagcgtttcg ggaatggagc aagacccctg tacctcgccg cgcgcgaatc      360

ttctttcgct atcagcaact gctcgtcgat cattgggacg aactcgcccg actgatcgtc      420

cgcgagaacg gcaagagcta caaggacgcc tacggggagg tgcagcgcgc gatcgaaaac      480

gtcgagtttg ccgcgagcgc gccgacgctc ctcatgggag aacaattggc caatatcgcg      540

acatccttgg actcgggcat gtaccggtac ccacttggcg tggtggcagg catcacgccg      600

ttcaactttc cgatgatggt cccttgctgg atgtttcctc tggccatcgt ctgcgggaac      660

acgttcgtgt tgaagccttc cgagcggacg ccgcttttgg cccagcggtt ggccgagctg      720

ctcgaggagg cgggcctgcc ctccggggtc ctcaacattg tgcacggcgc ccgagaggtc      780

gttcaaggcc tgatcgaaca tccgacggtt cgcgccatct cgttcgtcgg atcgcagccg      840

gtggccgcgt acgtgtaccg cgaagcggca gcccacggca agcgcgtgca ggcgctggca      900

ggcgccaaga atcacaccat cgtgatgccg gacgcggatc tggacgaagc catcccccag      960

atcatctcgg ccgcgttcgg ctcggcgggc gagcgctgca tggcctgttc cgtcgtcgtg     1020

gcagtaggtt ccatcgcaga tcgcctcgtc gaaggcctga agtccgctgc cgatcagatc     1080

cgcatcggca acggcctaga cgaagatgtc ctgcttggtc ccgtcatccg ggcagaacat     1140

cgagatcgga cgttgcagta catcgatctc ggcatccagg agggcgcggt ccttgtgcgc     1200

gacggacgcc aggatcgcgt ggatgcaaac gggtacttcg tcggacccac gattttcgat     1260

cacgtccgcc cttccatgaa gatctggcaa gacgagatct ttgcgcccgt gctgtcggtc     1320

gtgcgggtgg gcacgctgga cgaggccatc gcgttggcca accggtcccg gtttgcgaac     1380

ggagcctgca tcttcacgaa cagcgcgtcc gccattcgca agttccgcga ggaaatcgac     1440

gcaggaatgc ttggggtcaa catcggtgtt cctgctccca tggcgttctt ccccttctcg     1500

gggtggaagg attccttcta cggcgatctg cacgccaacg gcaaggacgg cgtggcgttt     1560

tacacgcgcc gaaagatgat cacggcaaga gtatga                               1596


<210>   1357
<211>   1596
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1345

<400>   1357
gtggcagccc agcgaaccac ccggtcgtgc cctcgcacga ggagatcgtc cagctgtacc       60

ggcaggccta tgacgccacg tgggatgcag cgccgatgga atcgcttaca aaatgagggg      120

gaagggaaga tgcataggac gtcgtccgtg agtgtagccg ggcacctgcg caattggatc      180

ggcggcgcgt ggcgagacgc ggaagccagc gaatacctcg acgtcttcga tccggcgacc      240

gcggaggtca tcgctcaggt gccgctgtcg acacaacaag acgtggaaat ggctgtggcg      300

gcggctgcgg aagcgtttcg ggaatggagc aagacccctg tacctcgccg cgcgcgaatc      360

ttctttcgct atcagcaact gctcgtcgat cattgggacg aactcgcccg actgatcgtc      420

cgcgagaacg gcaagagcta caaggacgcc tacggggagg tgcagcgcgc gatcgaaaac      480

gtcgagtttg ccgcgagcgc gccgacgctc ctcatgggag aacaattggc caatatcgcg      540

acatccttgg actcgggcat gtaccggtac ccacttggcg tggtggcagg catcacgccg      600

ttcaactttc cgatgatggt cccttgctgg atgtttcctc tggccatcgt ctgcgggaac      660

acgttcgtgt tgaagccttc cgagcggacg ccgcttttgg cccagcggtt ggccgagctg      720

ctcgaggagg cgggcctgcc ctccggggtc ctcaacattg tgcacggcgc ccgagaggtc      780

gttaatggcc tgatcgaaca tccgacggtt cgcgccatct cgttcgtcgg atcgcagccg      840

gtggccgcgt acgtgtaccg cgaagcggca gcccacggca agcgcgtgca ggcgctggca      900

ggcgccaaga atcacaccat cgtgatgccg gacgcggatc tggacgaagc catcccccag      960

atcatctcgg ccgcgttcgg ctcggcgggc gagcgctgca tggcctgttc cgtcgtcgtg     1020

gcagtaggtt ccatcgcaga tcgcctcgtc gaaggcctga agtccgctgc cgatcagatc     1080

cgcatcggca acggcctaga cgaagatgtc ctgcttggtc ccgtcatccg ggcagaacat     1140

cgagatcgga cgttgcagta catcgatctc ggcatccagg agggcgcggt ccttgtgcgc     1200

gacggacgcc aggatcgcgt ggatgcaaac gggtacttcg tcggacccac gattttcgat     1260

cacgtccgcc cttccatgaa gatctggcaa gacgagatct ttgcgcccgt gctgtcggtc     1320

gtgcgggtgg gcacgctgga cgaggccatc gcgttggcca accggtcccg gtttgcgaac     1380

ggagcctgca tcttcacgaa cagcgcgtcc gccattcgca agttccgcga ggaaatcgac     1440

gcaggaatgc ttggggtcaa catcggtgtt cctgctccca tggcgttctt ccccttctcg     1500

gggtggaagg attccttcta cggcgatctg cacgccaacg gcaaggacgg cgtggcgttt     1560

tacacgcgcc gaaagatgat cacggcaaga gtatga                               1596


<210>   1358
<211>   1596
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1345

<400>   1358
gtggcagccc agcgaaccac ccggtcgtgc cctcgcacga ggagatcgtc cagctgtacc       60

ggcaggccta tgacgccacg tgggatgcag cgccgatgga atcgcttaca aaatgagggg      120

gaagggaaga tgcataggac gtcgtccgtg agtgtagccg ggcacctgcg caattggatc      180

ggcggcgcgt ggcgagacgc ggaagccagc gaatacctcg acgtcttcga tccggcgacc      240

gcggaggtca tcgctcaggt gccgctgtcg acacaacaag acgtggaaat ggctgtggcg      300

gcggctgcgg aagcgtttcg ggaatggagc aagacccctg tacctcgccg cgcgcgaatc      360

ttctttcgct atcagcaact gctcgtcgat cattgggacg aactcgcccg actgatcgtc      420

cgcgagaacg gcaagagcta caaggacgcc tacggggagg tgcagcgcgc gatcgaaaac      480

gtcgagtttg ccgcgagcgc gccgacgctc ctcatgggag aacaattggc caatatcgcg      540

acatccttgg actcgggcat gtaccggtac ccacttggcg tggtggcagg catcacgccg      600

ttcaactttc cgatgatggt cccttgctgg atgtttcctc tggccatcgt ctgcgggaac      660

acgttcgtgt tgaagccttc cgagcggacg ccgcttttgg cccagcggtt ggccgagctg      720

ctcgaggagg cgggcctgcc ctccggggtc ctcaacattg tgcacggcgc ccgagaggtc      780

gttcaaggcc tgatcgaaca tccgacggtt cgcgccatct cgttcgtcgg atcgcagccg      840

gtggccgcgt acgtgtaccg cgaagcggca gcccacggca agcgcgtgca ggcgctggca      900

ggcgccaaga atcacaccat cgtgatgccg gacgcggatc tggacgaagc catcccccag      960

atcatctcgg ccgcgttcgg ctcggcgggc gagcgctgca tggcctgttc cgtcgtcgtg     1020

gcagtaggtt ccatcgcaga tcgcctcgtc gaaggcctga agtccgctgc cgatcagatc     1080

aaaatcggca acggcctaga cgaagatgtc ctgcttggtc ccgtcatccg ggcagaacat     1140

cgagatcgga cgttgcagta catcgatctc ggcatccagg agggcgcggt ccttgtgcgc     1200

gacggacgcc aggatcgcgt ggatgcaaac gggtacttcg tcggacccac gattttcgat     1260

cacgtccgcc cttccatgaa gatctggcaa gacgagatct ttgcgcccgt gctgtcggtc     1320

gtgcgggtgg gcacgctgga cgaggccatc gcgttggcca accggtcccg gtttgcgaac     1380

ggagcctgca tcttcacgaa cagcgcgtcc gccattcgca agttccgcga ggaaatcgac     1440

gcaggaatgc ttggggtcaa catcggtgtt cctgctccca tggcgttctt ccccttctcg     1500

gggtggaagg attccttcta cggcgatctg cacgccaacg gcaaggacgg cgtggcgttt     1560

tacacgcgcc gaaagatgat cacggcaaga gtatga                               1596


<210>   1359
<211>   1596
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1345

<400>   1359
gtggcagccc agcgaaccac ccggtcgtgc cctcgcacga ggagatcgtc cagctgtacc       60

ggcaggccta tgacgccacg tgggatgcag cgccgatgga atcgcttaca aaatgagggg      120

gaagggaaga tgcataggac gtcgtccgtg agtgtagccg ggcacctgcg caattggatc      180

ggcggcgcgt ggcgagacgc ggaagccagc gaatacctcg acgtcttcga tccggcgacc      240

gcggaggtca tcgctcaggt gccgctgtcg acacaacaag acgtggaaat ggctgtggcg      300

gcggctgcgg aagcgtttcg ggaatggagc aagacccctg tacctcgccg cgcgcgaatc      360

ttctttcgct atcagcaact gctcgtcgat cattgggacg aactcgcccg actgatcgtc      420

cgcgagaacg gcaagagcta caaggacgcc tacggggagg tgcagcgcgc gatcgaaaac      480

gtcgagtttg ccgcgagcgc gccgacgctc ctcatgggag aacaattggc caatatcgcg      540

acatccttgg actcgggcat gtaccggtac ccacttggcg tggtggcagg catcacgccg      600

ttcaactttc cgatgatggt cccttgctgg atgtttcctc tggccatcgt ctgcgggaac      660

acgttcgtgt tgaagccttc cgagcggacg ccgcttttgg cccagcggtt ggccgagctg      720

ctcgaggagg cgggcctgcc ctccggggtc ctcaacattg tgcacggcgc ccgagaggtc      780

gttcaaggcc tgatcgaaca tccgacggtt cgcgccatct cgttcgtcgg atcgcagccg      840

gtggccgcgt acgtgtaccg cgaagcggca gcccacggca agcgcgtgca ggcgctggca      900

ggcgccaaga atcacaccat cgtgatgccg gacgcggatc tggacgaagc catcccccag      960

atcatctcgg ccgcgttcgg ctcggcgggc gagcgctgca tggcctgttc cgtcgtcgtg     1020

gcagtaggtt ccatcgcaga tcgcctcgtc gaaggcctga agtccgctgc cgatcagatc     1080

cgcatcggca acggcctaga cgaagatgtc ctgcttggtc ccgtcatccg ggcagaacat     1140

cgagatcgga cgttgcagta catcgatctc ggcatccagg agggcgcggt ccttgtgcgc     1200

gacggacgcc aggatcgcgt ggatgcaaac gggtacttcg tcggacccac gattttcgat     1260

cacgtccgcc cttccatgaa gatctggcaa gacgagatct ttgcgcccgt gctgtcggtc     1320

gtgcgggtgg gcacgctgga cgaggccatc gcgttggcca accggtcccg gtttgcgaac     1380

ggagcctgca tcttcacgaa cagcgcgtcc gccattcgca agttccgcga ggaaatcgac     1440

gcaggaatgc ttggggtcaa catcggtgtt cctgctccca tggcgttctt ccccttctcg     1500

gggtggaagg attccttcta cggcgatctg cacgccaacg gcaaggacgg cgtggcgttt     1560

tacacgcgcc gaaagatgat cacggcaaga atttga                               1596


<210>   1360
<211>   1596
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1345

<400>   1360
gtggcagccc agcgaaccac caaatcgtgc cctcgcacga ggagatcgtc cagctgtacc       60

ggcaggccta tgacgccacg tgggatgcag cgccgatgga atcgcttaca aaatgagggg      120

gaagggaaga tgcataggac gtcgtccgtg agtgtagccg ggcacctgcg caattggatc      180

ggcggcgcgt ggcgagacgc ggaagccagc gaatacctcg acgtcttcga tccggcgacc      240

gcggaggtca tcgctcaggt gccgctgtcg acacaacaag acgtggaaat ggctgtggcg      300

gcggctgcgg aagcgtttcg ggaatggagc aagacccctg tacctcgccg cgcgcgaatc      360

ttctttcgct atcagcaact gctcgtcgat cattgggacg aactcgcccg actgatcgtc      420

cgcgagaacg gcaagagcta caaggacgcc tacggggagg tgcagcgcgc gatcgaaaac      480

gtcgagtttg ccgcgagcgc gccgacgctc ctcatgggag aacaattggc caatatcgcg      540

acatccttgg actcgggcat gtaccggtac ccacttggcg tggtggcagg catcacgccg      600

ttcaactttc cgatgatggt cccttgctgg atgtttcctc tggccatcgt ctgcgggaac      660

acgttcgtgt tgaagccttc cgagcggacg ccgcttttgg cccagcggtt ggccgagctg      720

ctcgaggagg cgggcctgcc ctccggggtc ctcaacattg tgcacggcgc ccgagaggtc      780

gttcaaggcc tgatcgaaca tccgacggtt cgcgccatct cgttcgtcgg atcgcagccg      840

gtggccgcgt acgtgtaccg cgaagcggca gcccacggca agcgcgtgca ggcgctggca      900

ggcgccaaga atcacaccat cgtgatgccg gacgcggatc tggacgaagc catcccccag      960

atcatctcgg ccgcgttcgg ctcggcgggc gagcgctgca tggcctgttc cgtcgtcgtg     1020

gcagtaggtt ccatcgcaga tcgcctcgtc gaaggcctga agtccgctgc cgatcagatc     1080

cgcatcggca acggcctaga cgaagatgtc ctgcttggtc ccgtcatccg ggcagaacat     1140

cgagatcgga cgttgcagta catcgatctc ggcatccagg agggcgcggt ccttgtgcgc     1200

gacggacgcc aggatcgcgt ggatgcaaac gggtacttcg tcggacccac gattttcgat     1260

cacgtccgcc cttccatgaa gatctggcaa gacgagatct ttgcgcccgt gctgtcggtc     1320

gtgcgggtgg gcacgctgga cgaggccatc gcgttggcca accggtcccg gtttgcgaac     1380

ggagcctgca tcttcacgaa cagcgcgtcc gccattcgca agttccgcga ggaaatcgac     1440

gcaggaatgc ttggggtcaa catcggtgtt cctgctccca tggcgttctt ccccttctcg     1500

gggtggaagg attccttcta cggcgatctg cacgccaacg gcaaggacgg cgtggcgttt     1560

tacacgcgcc gaaagatgat cacggcaaga gtatga                               1596


<210>   1361
<211>   402
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1361
Met Ser Arg Val Phe Gly Glu Phe Lys Val Pro Glu Ala Val Tyr Ala 
                5                   10                  15      

Gly Arg Gly Ala Leu Gln Met Leu Pro Gln Ala Ser Ser Ser Leu Gly 
            20                  25                  30          

Lys Arg Ala Leu Ile Val Thr Asp Glu Val Met Glu Arg Leu Gly Tyr 
        35                  40                  45              

Val Ala Gln Met Gln Arg Met Leu Ala Glu Ala Gly Val Gln Ala Asp 
    50                  55                  60                  

Val Phe Ala Glu Val Asn Thr Glu Pro Thr Asp Val His Val Glu Thr 
65                  70                  75                  80  

Gly Val Arg Ala Phe Leu Gln His Gly Cys Asp His Leu Ile Ala Leu 
                85                  90                  95      

Gly Gly Gly Ser Ala Ile Asp Ala Ala Lys Gly Ile Ser Val Met Ala 
            100                 105                 110         

Val His Glu Gly Tyr Ile Gly Asp Tyr Met Gly Gly Arg Arg Thr Phe 
        115                 120                 125             

Asp Lys Ala Pro Tyr Pro Val Ile Ala Ile Pro Thr Thr Ala Gly Thr 
    130                 135                 140                 

Gly Ser Glu Val Thr Ser Val Thr Val Ile Thr Asn Thr Lys Asp Asp 
145                 150                 155                 160 

Val Lys Met Met Ile Arg Gln Pro Ala Leu Leu Pro Lys Val Ala Ile 
                165                 170                 175     

Val Asp Pro Gln Leu Thr Val Ser Ser Pro Pro His Val Thr Ala Ser 
            180                 185                 190         

Ser Gly Val Asp Ala Leu Cys His Ala Ile Glu Ala Phe Ile Ser Arg 
        195                 200                 205             

Arg Ser His Pro Leu Thr Asp Ala Leu Ala Thr Asp Ala Ala Lys Lys 
    210                 215                 220                 

Ile Val Thr Tyr Leu Glu Arg Ala Tyr Asn Asp Gly Gln Asp Leu Glu 
225                 230                 235                 240 

Ala Arg Glu Gly Met Ala Ile Ala Ala Leu Glu Ala Gly Met Ala Phe 
                245                 250                 255     

Thr Asn Ser Ser Val Cys Leu Val His Gly Met Ser Arg Pro Ile Gly 
            260                 265                 270         

Ala Leu Phe His Val Pro His Gly Phe Ala Asn Ala Met Leu Leu Pro 
        275                 280                 285             

Thr Val Leu Glu Phe Arg Leu Asp Asp Tyr Ala Pro Arg Leu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Ala Leu Asn Pro Glu Leu Ser Gly Ala Ser Asp Gly Glu 
305                 310                 315                 320 

Ala Ala Ala Trp Val Val Arg Arg Val Lys Thr Leu Ala Glu Arg Leu 
                325                 330                 335     

Gln Ile Pro Asn Leu Lys Thr Trp Gly Ile Glu Arg Asp Ala Phe Glu 
            340                 345                 350         

Arg Ala Leu Asp Lys Met Ala Asn Asp Ala Leu Ala Ser Gly Ser Pro 
        355                 360                 365             

Ala Asn His Pro Val Val Pro Ser His Glu Glu Ile Val Gln Leu Tyr 
    370                 375                 380                 

Arg Gln Ala Tyr Asp Ala Thr Trp Asp Ala Ala Pro Met Glu Ser Leu 
385                 390                 395                 400 

Thr Lys 
        

<210>   1362
<211>   1209
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1362
gtgagcaggg tgtttggaga gttcaaagtc ccggaggctg tgtacgccgg gcgcggggcg       60

ctgcagatgc tgccgcaggc gtcgtccagc ctgggaaagc gggccctcat cgtgacggat      120

gaggtgatgg aacggctcgg ctacgtggca cagatgcaga ggatgttggc cgaggcgggc      180

gttcaagccg acgtgttcgc ggaggtgaac acggagccga ccgacgtgca cgtagagacc      240

ggcgtgcgcg cgttcttgca gcacggctgc gaccacctca tcgcgctcgg cgggggcagc      300

gccatcgacg ccgcgaaggg aatttccgtc atggcggtgc acgagggata catcggcgac      360

tatatgggcg gccgcaggac gttcgacaag gcgccgtacc ccgtgatcgc gatcccgacg      420

actgccggca cgggatccga ggtcaccagc gtaacggtta tcaccaatac caaggacgac      480

gtcaagatga tgatccggca acccgcgcta ttgcccaagg tcgcgatcgt ggacccccag      540

ctcaccgtct cgtcgcctcc ccatgtcacc gcttcgagcg gcgtggacgc gctgtgccac      600

gcgatcgagg cgtttatctc gagaagaagc catccgctga cggacgcgct ggccacggac      660

gctgcgaaga agatagtgac ctacttggag cgggcgtaca acgacggaca ggacctggag      720

gcgcgcgagg ggatggcgat cgcggcgctg gaagctggca tggccttcac gaattcatcc      780

gtgtgcctcg tgcatggcat gtcccgcccc atcggcgcct tgtttcacgt accacatggt      840

tttgccaacg ccatgctcct tccgactgtg ctggagttcc gacttgatga ctacgcgccg      900

aggctggcgc tgctcgcgcg ggccctgaat ccagaactgt ccggtgcgtc ggacggcgaa      960

gccgcggcgt gggtcgtgag gcgagtgaaa acgcttgccg agaggctcca gatcccaaat     1020

ctcaagactt ggggaattga aagggatgcc ttcgagcgcg cgctggataa gatggcgaac     1080

gatgccctcg cgagtggcag cccagcgaac cacccggtcg tgccctcgca cgaggagatc     1140

gtccagctgt accggcaggc ctatgacgcc acgtgggatg cagcgccgat ggaatcgctt     1200

acaaaatga                                                             1209


<210>   1363
<211>   387
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1363
Glu Leu Leu Val Pro Asn Arg Val Ile Tyr Gly Arg Asp Thr Phe Arg 
                5                   10                  15      

Glu Val Gly Arg Gln Ala Lys Ala Leu Gly Thr Lys Ala Leu Ile Val 
            20                  25                  30          

Ser Asp Pro Val Met Glu Asn Ile Gly Leu Val Ala Arg Cys Glu Gln 
        35                  40                  45              

Tyr Leu Arg Glu Ala Gly Leu Pro Leu Ala Thr Tyr Thr Arg Val Asp 
    50                  55                  60                  

Thr Glu Pro Thr Asp Val His Val Lys Glu Ala Leu Asp Val Cys Arg 
65                  70                  75                  80  

Ser Glu Gln Cys Asp Val Ile Val Ala Ile Gly Gly Gly Ser Ser Ile 
                85                  90                  95      

Asp Ala Ala Lys Ala Val Ala Val Met Met Thr Asn Glu Gly Thr Ile 
            100                 105                 110         

Ser Asp Tyr Val Gly Asn Ala Lys Met Phe Thr Lys Lys Pro Val Pro 
        115                 120                 125             

Leu Ile Ala Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Val Thr Lys 
    130                 135                 140                 

Val Thr Val Ile Ile Asp Thr Lys Thr Asp Val Lys Met Met Ile Ser 
145                 150                 155                 160 

Gln Pro Ala Leu Leu Pro Ala Val Ala Ile Val Asp Pro Leu Leu Thr 
                165                 170                 175     

Val Ser Cys Pro Pro Ser Val Thr Ala Ala Thr Gly Val Asp Ala Leu 
            180                 185                 190         

Cys His Ser Ile Glu Ala Tyr Ile Ser Arg Arg Ala His Pro Val Thr 
        195                 200                 205             

Asp Val Leu Ala Leu Ser Ala Ile Glu Ala Ile Ile Gly His Leu Arg 
    210                 215                 220                 

Arg Ala Tyr Glu Asn Gly Gln Asp Ile Glu Ala Arg Glu Lys Met Ala 
225                 230                 235                 240 

Ile Ala Ala Met Lys Ala Gly Met Ala Phe Ser Asn Ala Ser Val Thr 
                245                 250                 255     

Leu Val His Gly Met Ser Arg Pro Ile Gly Ala Leu Phe His Val Pro 
            260                 265                 270         

His Gly Val Ser Asn Ala Met Leu Leu Pro Gly Val Leu Glu Phe Thr 
        275                 280                 285             

Lys Glu Ser Ala Ile Glu Arg Leu Ala Val Ile Ala Arg Leu Ile Asn 
    290                 295                 300                 

Pro Gln Leu Lys Asp Val Ser Asn Ala Glu Ala Ala Asp Ala Leu Val 
305                 310                 315                 320 

Glu Glu Val Lys Gln Leu Cys Arg Asp Leu His Ile Pro Asn Met Lys 
                325                 330                 335     

Thr Trp Gly Ile Asp Lys Thr Ala Phe Asp Lys Ala Val Asp Lys Met 
            340                 345                 350         

Ala Ala Asp Ala Leu Ala Ser Gly Ser Pro Ser Asn Asn Pro Arg Val 
        355                 360                 365             

Pro Thr His Glu Glu Ile Val Ala Leu Tyr His Ile Cys Tyr Asp Tyr 
    370                 375                 380                 

Arg Tyr Asp 
385         

<210>   1364
<211>   393
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1364
Glu Leu Leu Val Pro Ser Arg Val Val Tyr Gly Arg Asp Thr Phe Ala 
                5                   10                  15      

Glu Val Gly Pro Gln Ala Lys Ala Leu Gly Thr Lys Ala Leu Ile Val 
            20                  25                  30          

Ser Asp Pro Val Met Glu Lys Ile Gly Leu Val Ala Arg Cys Glu Gln 
        35                  40                  45              

Tyr Leu Gln Gln Val Gly Met Thr Phe Ala Lys Tyr Thr Gly Val Asp 
    50                  55                  60                  

Thr Glu Pro Thr Asp Val His Val Lys Glu Ala Leu Asp Val Cys Arg 
65                  70                  75                  80  

Ser Glu Gln Cys Asp Val Ile Ile Ala Leu Gly Gly Gly Ser Ser Ile 
                85                  90                  95      

Asp Ala Ala Lys Ala Val Ser Val Met Met Thr Asn Glu Gly Thr Ile 
            100                 105                 110         

Ser Asp Tyr Val Gly Asn Gln Lys Arg Phe Thr Glu Lys Pro Leu Pro 
        115                 120                 125             

Leu Ile Ala Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Val Thr Lys 
    130                 135                 140                 

Val Thr Val Ile Ile Asp Thr Lys Met Asp Val Lys Met Met Ile Ser 
145                 150                 155                 160 

Gln Pro Ala Leu Leu Pro Ala Val Ala Ile Val Asp Pro Leu Leu Thr 
                165                 170                 175     

Val Ser Cys Pro Pro Ser Val Thr Ala Ala Thr Gly Val Asp Ala Leu 
            180                 185                 190         

Cys His Ala Ile Glu Ala Tyr Ile Ser Arg Arg Ala His Pro Val Thr 
        195                 200                 205             

Asp Ala Leu Ala Leu Ser Ala Ile Glu Ala Ile Val Gly His Leu Arg 
    210                 215                 220                 

Arg Ala Tyr Glu Asn Gly Gln Asp Ile Glu Ala Arg Glu Lys Met Ala 
225                 230                 235                 240 

Ile Ala Ala Met Lys Ala Gly Met Ala Phe Ser Asn Ala Ser Val Thr 
                245                 250                 255     

Leu Val His Gly Met Ser Arg Pro Ile Gly Ala Leu Phe His Val Pro 
            260                 265                 270         

His Gly Val Ser Asn Ala Met Leu Leu Pro Gly Val Leu Glu Phe Thr 
        275                 280                 285             

Lys Asp Ser Ala Ile Glu Arg Leu Ala Val Ile Val Arg Ile Ile Lys 
    290                 295                 300                 

Pro Pro Leu Lys Asp Val Ser Asp Thr Glu Ala Ala Glu Ala Leu Val 
305                 310                 315                 320 

Glu Glu Val Lys Gln Leu Cys Arg Asp Leu His Ile Pro Asn Met Lys 
                325                 330                 335     

Thr Trp Gly Ile Asp Lys Thr Ala Phe Asp Lys Val Val Asp Lys Met 
            340                 345                 350         

Ala Ala Asp Ala Leu Ala Ser Gly Ser Pro Ala Asn Asn Pro Lys Val 
        355                 360                 365             

Pro Thr His Glu Glu Ile Val Ala Leu Tyr His Tyr Cys Tyr Asp Tyr 
    370                 375                 380                 

Gln Tyr Asp Thr Lys Thr Val Ser Ser 
385                 390             

<210>   1365
<211>   388
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   1365
Phe Arg Val Pro Glu Ser Ile Phe Tyr Gly Arg Gly Ser Phe Glu Asn 
                5                   10                  15      

Leu Gly Ser Gln Ala Ala Leu Lys Gly Lys Lys Ala Leu Ile Ile Ser 
            20                  25                  30          

Asp Asn Val Met Asp Gln Leu Gly Tyr Val Thr Glu Gly Arg Ala Leu 
        35                  40                  45              

Leu His Val Ala Gly Val Gln Ser Glu Val Tyr Leu Gly Ile Ala Ser 
    50                  55                  60                  

Glu Pro Thr Asp Lys Tyr Val Ser Glu Ala Leu Asp Leu Phe Lys Ser 
65                  70                  75                  80  

Glu Gln Cys Asp Leu Val Ile Ser Ile Gly Gly Gly Ser Cys Ile Asp 
                85                  90                  95      

Thr Ala Lys Ala Ile Ala Val Leu Ala Val Asn Gly Gly Ser Ile Gly 
            100                 105                 110         

Asp Tyr Leu Gly Gly Lys Lys Leu Ala Gln Gln Thr Pro Val Pro His 
        115                 120                 125             

Ile Ala Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Ala Thr Asp Val 
    130                 135                 140                 

Thr Val Ile Thr Asn Thr Phe Asn Asn Val Lys Met Met Ile Lys Gln 
145                 150                 155                 160 

Pro Ala Phe Leu Pro Asp Ala Ala Ile Val Asp Pro Leu Leu Thr Val 
                165                 170                 175     

Ser Ser Pro Lys Asn Ile Thr Ala Ala Thr Gly Ile Asp Ala Leu Ser 
            180                 185                 190         

His Ala Ile Glu Ala Tyr Leu Ser Lys Lys Ala His Pro Met Thr Asp 
        195                 200                 205             

Thr Met Ala Ile Ser Ala Met Lys Leu Ile Ala Glu Asn Ile Leu Thr 
    210                 215                 220                 

Ala Tyr Asn Asp Gly Gly Asn Leu Asp Ala Arg Glu Arg Met Ser Leu 
225                 230                 235                 240 

Gly Ser Leu Gln Ala Gly Met Ala Phe Ser Asn Ala Ser Val Cys Leu 
                245                 250                 255     

Val His Gly Met Ser Arg Pro Ile Gly Ala Leu Phe His Val Pro His 
            260                 265                 270         

Gly Ile Ser Asn Ala Met Leu Leu Pro Ala Val Leu Glu Phe Ser Gln 
        275                 280                 285             

Glu Ala Cys Val Glu Arg Leu Ala Asp Ile Gly Arg Ile Phe Arg Pro 
    290                 295                 300                 

Asp Ile Val Ser Gly Asp Gly Val Lys Ala Ala Glu Ile Ala Val Gln 
305                 310                 315                 320 

Ser Val Lys Glu Leu Cys Arg Lys Leu Asn Ile Pro Asn Leu Lys Glu 
                325                 330                 335     

Trp Gly Ile Asp Gly Glu Ala Phe Glu Lys Ala Val Gly Lys Met Ala 
            340                 345                 350         

Ala Asp Ala Ile Asp Ser Gly Ser Pro Ala Asn Asn Pro Lys Val Pro 
        355                 360                 365             

Ser Gln Leu Glu Leu Glu Glu Leu Tyr His Ile Cys Tyr Asp Tyr His 
    370                 375                 380                 

Phe Ser Ser Ala 
385             

<210>   1366
<211>   382
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   1366
Phe Arg Thr Pro Gln Thr Ile Leu Tyr Gly Lys Gln Ala Phe Glu Lys 
                5                   10                  15      

Ile Gly Glu Glu Ala Ala Arg Arg Gly Lys Lys Ala Leu Ile Val Thr 
            20                  25                  30          

Asp Lys Ile Met Ala Gly Leu Gly Asn Ala Asp Ala Cys Gln His Ile 
        35                  40                  45              

Leu Gln Glu Ala Gly Val Lys Ser Ala Val Tyr Ala Gly Val Asn Ser 
    50                  55                  60                  

Glu Pro Val Asp His Tyr Val Ser Glu Ala Leu Ala Leu Phe Gln Gln 
65                  70                  75                  80  

Glu Ser Cys Asp Leu Leu Val Ser Leu Gly Gly Gly Ser Cys Ile Asp 
                85                  90                  95      

Thr Ala Lys Ala Val Ala Val Val Ala Thr Asn Gly Gly Tyr Ile Gly 
            100                 105                 110         

Asp Tyr Met Gly Ala Arg Lys Ile Ala Glu Lys Pro Pro Val Ala His 
        115                 120                 125             

Ile Ala Val Pro Thr Thr Ala Gly Thr Gly Ser Glu Ala Thr Asp Ala 
    130                 135                 140                 

Thr Ile Ile Thr Asn Thr Ala Asn Asp Val Lys Met Met Ile Lys Gln 
145                 150                 155                 160 

Pro Ala Phe Met Pro Ala Val Ala Ile Val Asp Pro Val Leu Ser Lys 
                165                 170                 175     

Ser Ser Pro Lys Ser Val Thr Ala Ala Thr Gly Val Asp Ala Leu Ser 
            180                 185                 190         

His Ala Ile Glu Ala Tyr Ile Ser Arg Arg Ala His Pro Leu Thr Asp 
        195                 200                 205             

Thr Leu Ala Leu Ser Ala Met Arg Leu Ile Ile Pro Asn Leu Lys Ser 
    210                 215                 220                 

Ala Tyr Glu Asp Gly Glu Asn Met Glu Ala Arg Asp Ala Met Ala Leu 
225                 230                 235                 240 

Gly Ser Leu Gln Ala Gly Met Ala Phe Ser Asn Ala Ser Val Cys Leu 
                245                 250                 255     

Val His Gly Met Ser Arg Pro Ile Gly Ala Leu Phe His Val Pro His 
            260                 265                 270         

Gly Val Ser Asn Ala Met Leu Leu Pro Ala Val Leu Glu Phe Ser Lys 
        275                 280                 285             

Ser Val Cys Leu Glu Arg Leu Ala Asp Ile Gly Lys Ile Phe Ser Pro 
    290                 295                 300                 

Glu Ala Lys Asp Leu Ser Gly Lys Glu Ala Ala Asp Leu Ala Val Arg 
305                 310                 315                 320 

Ala Val Lys Gln Leu Cys Leu Asp Leu Asn Ile Pro Asn Leu Arg Gly 
                325                 330                 335     

Trp Gly Ile Pro Gln Gln Pro Phe Glu Ser Ala Ile Asn Lys Met Ala 
            340                 345                 350         

Ser Asp Ala Leu Ala Ser Gly Ser Pro Gln Asn Asn Pro Arg Val Pro 
        355                 360                 365             

Ser Gln Lys Glu Ile Glu Asp Leu Tyr Leu Val Cys Tyr Asp 
    370                 375                 380         

<210>   1367
<211>   383
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   1367
Glu Phe Arg Met Pro Lys Ser Val Leu Tyr Gly Arg Asn Ser Leu Glu 
                5                   10                  15      

Lys Leu Gly Glu Gln Ser Lys Lys Leu Gly Lys Arg Ala Phe Ile Val 
            20                  25                  30          

Thr Asp Thr Ile Met Glu Lys Leu Gly Tyr Val Glu Lys Cys Met Gln 
        35                  40                  45              

Gln Leu Asn Lys Lys Gly Ile Thr Val Ser Thr Tyr Asn Lys Val Asp 
    50                  55                  60                  

Ala Glu Pro Thr Asn Ile His Val Leu Glu Ala Leu Ser Leu Cys Lys 
65                  70                  75                  80  

Glu Glu Lys Cys Asp Phe Ile Ile Gly Ile Gly Gly Gly Ser Cys Ile 
                85                  90                  95      

Asp Ala Ala Lys Ala Val Ala Val Leu Tyr Thr Asn Gly Gly Glu Val 
            100                 105                 110         

Glu Asp Tyr Val Gln Lys Asp Ile Lys Ile Glu Asn Lys Pro Leu Pro 
        115                 120                 125             

Leu Ile Ala Ile Pro Thr Thr Ser Gly Thr Gly Ser Glu Val Thr Ser 
    130                 135                 140                 

Val Ala Val Ile Thr Asn Lys Lys Thr Asp Val Lys Met Met Met Lys 
145                 150                 155                 160 

His Pro Ser Phe Ile Pro Lys Val Ala Ile Ile Asp Pro Val Leu Thr 
                165                 170                 175     

Ser Ser Leu Pro Pro Gln Ile Thr Ala Ala Thr Gly Ile Asp Ala Leu 
            180                 185                 190         

Cys His Ala Ile Glu Ala Tyr Ile Ser Lys Phe Ser Gln Pro Leu Thr 
        195                 200                 205             

Asp Val Leu Ala Leu Ser Ala Ile Glu Ser Ile Met Lys Tyr Leu Arg 
    210                 215                 220                 

Ile Ala Tyr Glu Asp Gly Arg Asn Met Glu Ala Arg Glu Ala Met Met 
225                 230                 235                 240 

Ile Ala Ser Leu Gln Ala Gly Ile Ala Phe Ser Asn Ala Ser Val Thr 
                245                 250                 255     

Leu Val His Gly Met Ser Arg Pro Val Gly Ala Leu Phe His Val Pro 
            260                 265                 270         

His Gly Ile Ser Asn Ala Ile Leu Leu Pro Thr Val Leu Glu Phe Thr 
        275                 280                 285             

Lys Thr Ser Ala Met Lys Arg Leu Ala Lys Ile Gly Arg Ser Leu Asn 
    290                 295                 300                 

Lys Asp Leu Tyr Ser Asn Ser Asp Glu Glu Val Ala Asp Tyr Thr Leu 
305                 310                 315                 320 

Gly Glu Ile Lys Lys Leu Cys Phe Asp Leu Arg Ile Pro Asn Leu Lys 
                325                 330                 335     

Glu Tyr Gly Ile Asp Glu Ile Glu Phe Glu Asn Ala Ile Ser Lys Met 
            340                 345                 350         

Ala Ser Asp Ala Ile Glu Ser Gly Ser Pro Ala Asn Asn Pro Arg Val 
        355                 360                 365             

Pro Ser Tyr Asp Glu Ile Lys Glu Leu Tyr Arg Glu Cys Phe Asn 
    370                 375                 380             

<210>   1368
<211>   402
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1361

<400>   1368
Met Ser Arg Val Phe Gly Glu Phe Lys Val Pro Glu Ala Val Tyr Ala 
                5                   10                  15      

Gly Arg Gly Ala Leu Gln Met Leu Pro Gln Ala Ser Ser Ser Leu Gly 
            20                  25                  30          

Lys Arg Ala Leu Ile Val Thr Asp Glu Val Met Glu Arg Leu Gly Tyr 
        35                  40                  45              

Val Ala Gln Met Gln Arg Met Leu Ala Glu Ala Gly Val Gln Ala Asp 
    50                  55                  60                  

Val Phe Ala Glu Val Asn Thr Glu Pro Thr Asp Val His Val Glu Thr 
65                  70                  75                  80  

Gly Val Arg Ala Phe Leu Gln His Gly Cys Asp His Leu Ile Ala Leu 
                85                  90                  95      

Gly Gly Gly Ser Ala Ile Asp Ala Ala Lys Gly Ile Ser Val Met Ala 
            100                 105                 110         

Val His Glu Gly Tyr Ile Gly Asp Tyr Met Gly Gly Arg Arg Thr Phe 
        115                 120                 125             

Asp Lys Ala Pro Tyr Pro Val Ile Ala Ile Pro Thr Thr Ala Gly Thr 
    130                 135                 140                 

Gly Ser Glu Val Thr Ser Val Thr Val Ile Thr Asn Thr Lys Asp Asp 
145                 150                 155                 160 

Val Lys Met Met Ile Arg Gln Pro Ala Leu Leu Pro Lys Val Ala Ile 
                165                 170                 175     

Val Asp Pro Gln Leu Thr Val Ser Ser Pro Pro His Val Thr Ala Ser 
            180                 185                 190         

Ser Gly Val Asp Ala Leu Cys His Ala Ile Glu Ala Phe Ile Ser Arg 
        195                 200                 205             

Arg Ser His Pro Leu Thr Asp Ala Leu Ala Thr Asp Ala Ala Lys Arg 
    210                 215                 220                 

Ile Val Thr Tyr Leu Glu Arg Ala Tyr Asn Asp Gly Gln Asp Leu Glu 
225                 230                 235                 240 

Ala Arg Glu Gly Met Ala Ile Ala Ala Leu Glu Ala Gly Met Ala Phe 
                245                 250                 255     

Thr Asn Ser Ser Val Cys Leu Val His Gly Met Ser Arg Pro Ile Gly 
            260                 265                 270         

Ala Leu Phe His Val Pro His Gly Phe Ala Asn Ala Met Leu Leu Pro 
        275                 280                 285             

Thr Val Leu Glu Phe Arg Leu Asp Asp Tyr Ala Pro Arg Leu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Ala Leu Asn Pro Glu Leu Ser Gly Ala Ser Asp Gly Glu 
305                 310                 315                 320 

Ala Ala Ala Trp Val Val Arg Arg Val Lys Thr Leu Ala Glu Arg Leu 
                325                 330                 335     

Gln Ile Pro Asn Leu Lys Thr Trp Gly Ile Glu Arg Asp Ala Phe Glu 
            340                 345                 350         

Arg Ala Leu Asp Lys Met Ala Asn Asp Ala Leu Ala Ser Gly Ser Pro 
        355                 360                 365             

Ala Asn His Pro Val Val Pro Ser His Glu Glu Ile Val Gln Leu Tyr 
    370                 375                 380                 

Arg Gln Ala Tyr Asp Ala Thr Trp Asp Ala Ala Pro Met Glu Ser Leu 
385                 390                 395                 400 

Thr Lys 
        

<210>   1369
<211>   402
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1361

<400>   1369
Met Ser Arg Val Phe Gly Glu Phe Lys Val Pro Glu Ala Val Tyr Ala 
                5                   10                  15      

Gly Arg Gly Ala Leu Gln Met Leu Pro Gln Ala Ser Ser Ser Leu Gly 
            20                  25                  30          

Lys Arg Ala Leu Ile Val Thr Asp Glu Val Met Glu Arg Leu Gly Tyr 
        35                  40                  45              

Val Ala Gln Met Gln Arg Met Leu Ala Glu Ala Gly Val Gln Ala Asp 
    50                  55                  60                  

Val Phe Ala Glu Val Asn Thr Glu Pro Thr Asp Val His Val Glu Thr 
65                  70                  75                  80  

Gly Val Arg Ala Phe Leu Gln His Gly Cys Asp His Leu Ile Ala Leu 
                85                  90                  95      

Gly Gly Gly Ser Ala Ile Asp Ala Ala Lys Gly Ile Ser Val Met Ala 
            100                 105                 110         

Val His Glu Gly Tyr Ile Gly Asp Tyr Met Gly Gly Arg Arg Thr Phe 
        115                 120                 125             

Asp Lys Ala Pro Tyr Pro Val Ile Ala Ile Pro Thr Thr Ala Gly Thr 
    130                 135                 140                 

Gly Ser Glu Val Thr Ser Val Thr Val Ile Thr Asn Thr Lys Asp Asp 
145                 150                 155                 160 

Val Lys Met Met Ile Arg Gln Pro Ala Leu Leu Pro Lys Val Ala Ile 
                165                 170                 175     

Val Asp Pro Gln Leu Thr Val Ser Ser Pro Pro His Val Thr Ala Ser 
            180                 185                 190         

Ser Gly Val Asp Ala Leu Cys His Ala Ile Glu Ala Phe Ile Ser Arg 
        195                 200                 205             

Arg Ser His Pro Leu Thr Asp Ala Leu Ala Thr Asp Ala Ala Lys Lys 
    210                 215                 220                 

Ile Val Thr Tyr Leu Glu Arg Ala Tyr Asn Asp Gly Gln Asp Leu Glu 
225                 230                 235                 240 

Ala Arg Glu Gly Met Ala Ile Ala Ala Leu Glu Ala Gly Met Ala Phe 
                245                 250                 255     

Thr Asn Ser Ser Val Cys Leu Val His Gly Met Ser Arg Pro Ile Gly 
            260                 265                 270         

Ala Leu Phe His Val Pro His Gly Phe Ala Asn Ala Met Leu Leu Pro 
        275                 280                 285             

Thr Val Leu Glu Phe Arg Leu Asp Asp Tyr Ala Pro Arg Leu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Ala Leu Asn Pro Glu Leu Ser Gly Ala Ser Asp Gly Glu 
305                 310                 315                 320 

Ala Ala Ala Trp Val Val Arg Arg Val Lys Thr Leu Ala Glu Arg Leu 
                325                 330                 335     

Gln Ile Pro Asn Leu Lys Thr Trp Gly Ile Glu Arg Asp Ala Phe Glu 
            340                 345                 350         

Arg Ala Leu Asp Lys Met Ala Asn Asp Ala Leu Ala Ser Gly Ser Pro 
        355                 360                 365             

Ala Asn His Pro Val Val Pro Ser His Asp Glu Ile Val Gln Leu Tyr 
    370                 375                 380                 

Arg Gln Ala Tyr Asp Ala Thr Trp Asp Ala Ala Pro Met Glu Ser Leu 
385                 390                 395                 400 

Thr Lys 
        

<210>   1370
<211>   402
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1361

<400>   1370
Met Ser Arg Val Phe Gly Glu Phe Lys Val Pro Glu Ala Val Tyr Ala 
                5                   10                  15      

Gly Arg Gly Ala Leu Gln Met Leu Pro Gln Ala Ser Ser Ser Leu Gly 
            20                  25                  30          

Lys Arg Ala Leu Ile Val Thr Asp Glu Val Met Glu Arg Leu Gly Tyr 
        35                  40                  45              

Val Ala Gln Met Gln Arg Met Leu Ala Glu Ala Gly Val Gln Ala Asp 
    50                  55                  60                  

Val Phe Ala Glu Val Asn Thr Glu Pro Thr Asp Val His Val Glu Thr 
65                  70                  75                  80  

Gly Val Arg Ala Phe Leu Gln His Gly Cys Asp His Leu Ile Ala Leu 
                85                  90                  95      

Gly Gly Gly Ser Ala Ile Asp Ala Ala Lys Gly Ile Ser Val Met Ala 
            100                 105                 110         

Val His Glu Gly Tyr Ile Gly Asp Tyr Met Gly Gly Arg Arg Thr Phe 
        115                 120                 125             

Asp Lys Ala Pro Tyr Pro Val Ile Ala Ile Pro Thr Thr Ala Gly Thr 
    130                 135                 140                 

Gly Ser Glu Val Thr Ser Val Thr Val Ile Thr Asn Thr Lys Asp Asp 
145                 150                 155                 160 

Val Lys Met Met Ile Arg Gln Pro Ala Leu Leu Pro Lys Val Ala Ile 
                165                 170                 175     

Val Asp Pro Gln Leu Thr Val Ser Ser Pro Pro His Val Thr Ala Ser 
            180                 185                 190         

Ser Gly Val Asp Ala Leu Cys His Ala Ile Glu Ala Phe Ile Ser Arg 
        195                 200                 205             

Arg Ser His Pro Leu Thr Asp Ala Leu Ala Thr Asp Ala Ala Lys Lys 
    210                 215                 220                 

Ile Val Thr Tyr Leu Glu Arg Ala Tyr Asn Asp Gly Gln Asp Leu Glu 
225                 230                 235                 240 

Ala Arg Glu Gly Met Ala Ile Ala Ala Leu Glu Ala Gly Met Ala Phe 
                245                 250                 255     

Thr Asn Ser Ser Val Cys Leu Val His Gly Met Ser Arg Pro Ile Gly 
            260                 265                 270         

Ala Leu Phe His Val Pro His Gly Phe Ala Asn Ala Met Leu Leu Pro 
        275                 280                 285             

Thr Val Leu Glu Phe Arg Leu Asp Asp Tyr Ala Pro Arg Leu Ala Ile 
    290                 295                 300                 

Leu Ala Arg Ala Leu Asn Pro Glu Leu Ser Gly Ala Ser Asp Gly Glu 
305                 310                 315                 320 

Ala Ala Ala Trp Val Val Arg Arg Val Lys Thr Leu Ala Glu Arg Leu 
                325                 330                 335     

Gln Ile Pro Asn Leu Lys Thr Trp Gly Ile Glu Arg Asp Ala Phe Glu 
            340                 345                 350         

Arg Ala Leu Asp Lys Met Ala Asn Asp Ala Leu Ala Ser Gly Ser Pro 
        355                 360                 365             

Ala Asn His Pro Val Val Pro Ser His Glu Glu Ile Val Gln Leu Tyr 
    370                 375                 380                 

Arg Gln Ala Tyr Asp Ala Thr Trp Asp Ala Ala Pro Met Glu Ser Leu 
385                 390                 395                 400 

Thr Lys 
        

<210>   1371
<211>   402
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1361

<400>   1371
Met Ser Arg Val Phe Gly Glu Phe Lys Val Pro Glu Ala Val Tyr Ala 
                5                   10                  15      

Gly Arg Gly Ala Leu Gln Met Leu Pro Gln Ala Ser Ser Ser Leu Gly 
            20                  25                  30          

Lys Arg Ala Leu Ile Val Thr Asp Glu Val Met Glu Arg Leu Gly Tyr 
        35                  40                  45              

Val Ala Gln Met Gln Arg Met Leu Ala Glu Ala Gly Val Asn Ala Asp 
    50                  55                  60                  

Val Phe Ala Glu Val Asn Thr Glu Pro Thr Asp Val His Val Glu Thr 
65                  70                  75                  80  

Gly Val Arg Ala Phe Leu Gln His Gly Cys Asp His Leu Ile Ala Leu 
                85                  90                  95      

Gly Gly Gly Ser Ala Ile Asp Ala Ala Lys Gly Ile Ser Val Met Ala 
            100                 105                 110         

Val His Glu Gly Tyr Ile Gly Asp Tyr Met Gly Gly Arg Arg Thr Phe 
        115                 120                 125             

Asp Lys Ala Pro Tyr Pro Val Ile Ala Ile Pro Thr Thr Ala Gly Thr 
    130                 135                 140                 

Gly Ser Glu Val Thr Ser Val Thr Val Ile Thr Asn Thr Lys Asp Asp 
145                 150                 155                 160 

Val Lys Met Met Ile Arg Gln Pro Ala Leu Leu Pro Lys Val Ala Ile 
                165                 170                 175     

Val Asp Pro Gln Leu Thr Val Ser Ser Pro Pro His Val Thr Ala Ser 
            180                 185                 190         

Ser Gly Val Asp Ala Leu Cys His Ala Ile Glu Ala Phe Ile Ser Arg 
        195                 200                 205             

Arg Ser His Pro Leu Thr Asp Ala Leu Ala Thr Asp Ala Ala Lys Lys 
    210                 215                 220                 

Ile Val Thr Tyr Leu Glu Arg Ala Tyr Asn Asp Gly Gln Asp Leu Glu 
225                 230                 235                 240 

Ala Arg Glu Gly Met Ala Ile Ala Ala Leu Glu Ala Gly Met Ala Phe 
                245                 250                 255     

Thr Asn Ser Ser Val Cys Leu Val His Gly Met Ser Arg Pro Ile Gly 
            260                 265                 270         

Ala Leu Phe His Val Pro His Gly Phe Ala Asn Ala Met Leu Leu Pro 
        275                 280                 285             

Thr Val Leu Glu Phe Arg Leu Asp Asp Tyr Ala Pro Arg Leu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Ala Leu Asn Pro Glu Leu Ser Gly Ala Ser Asp Gly Glu 
305                 310                 315                 320 

Ala Ala Ala Trp Val Val Arg Arg Val Lys Thr Leu Ala Glu Arg Leu 
                325                 330                 335     

Gln Ile Pro Asn Leu Lys Thr Trp Gly Ile Glu Arg Asp Ala Phe Glu 
            340                 345                 350         

Arg Ala Leu Asp Lys Met Ala Asn Asp Ala Leu Ala Ser Gly Ser Pro 
        355                 360                 365             

Ala Asn His Pro Val Val Pro Ser His Glu Glu Ile Val Gln Leu Tyr 
    370                 375                 380                 

Arg Gln Ala Tyr Asp Ala Thr Trp Asp Ala Ala Pro Met Glu Ser Leu 
385                 390                 395                 400 

Thr Lys 
        

<210>   1372
<211>   402
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1361

<400>   1372
Met Ser Arg Val Phe Gly Glu Phe Lys Val Pro Glu Ala Val Tyr Ala 
                5                   10                  15      

Gly Arg Gly Ala Leu Gln Met Leu Pro Gln Ala Ser Ser Ser Leu Gly 
            20                  25                  30          

Lys Arg Ala Leu Ile Val Thr Asp Glu Val Met Glu Arg Leu Gly Tyr 
        35                  40                  45              

Val Ala Gln Met Gln Arg Met Leu Ala Glu Ala Gly Val Gln Ala Asp 
    50                  55                  60                  

Val Phe Ala Glu Val Asn Thr Glu Pro Thr Asp Val His Val Glu Thr 
65                  70                  75                  80  

Gly Val Arg Ala Phe Leu Gln His Gly Cys Asp His Leu Ile Ala Leu 
                85                  90                  95      

Gly Gly Gly Ser Ala Ile Asp Ala Ala Lys Gly Ile Ser Val Met Ala 
            100                 105                 110         

Val His Glu Gly Tyr Ile Gly Asp Tyr Met Gly Gly Arg Arg Thr Phe 
        115                 120                 125             

Glu Lys Ala Pro Tyr Pro Val Ile Ala Ile Pro Thr Thr Ala Gly Thr 
    130                 135                 140                 

Gly Ser Glu Val Thr Ser Val Thr Val Ile Thr Asn Thr Lys Asp Asp 
145                 150                 155                 160 

Val Lys Met Met Ile Arg Gln Pro Ala Leu Leu Pro Lys Val Ala Ile 
                165                 170                 175     

Val Asp Pro Gln Leu Thr Val Ser Ser Pro Pro His Val Thr Ala Ser 
            180                 185                 190         

Ser Gly Val Asp Ala Leu Cys His Ala Ile Glu Ala Phe Ile Ser Arg 
        195                 200                 205             

Arg Ser His Pro Leu Thr Asp Ala Leu Ala Thr Asp Ala Ala Lys Lys 
    210                 215                 220                 

Ile Val Thr Tyr Leu Glu Arg Ala Tyr Asn Asp Gly Gln Asp Leu Glu 
225                 230                 235                 240 

Ala Arg Glu Gly Met Ala Ile Ala Ala Leu Glu Ala Gly Met Ala Phe 
                245                 250                 255     

Thr Asn Ser Ser Val Cys Leu Val His Gly Met Ser Arg Pro Ile Gly 
            260                 265                 270         

Ala Leu Phe His Val Pro His Gly Phe Ala Asn Ala Met Leu Leu Pro 
        275                 280                 285             

Thr Val Leu Glu Phe Arg Leu Asp Asp Tyr Ala Pro Arg Leu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Ala Leu Asn Pro Glu Leu Ser Gly Ala Ser Asp Gly Glu 
305                 310                 315                 320 

Ala Ala Ala Trp Val Val Arg Arg Val Lys Thr Leu Ala Glu Arg Leu 
                325                 330                 335     

Gln Ile Pro Asn Leu Lys Thr Trp Gly Ile Glu Arg Asp Ala Phe Glu 
            340                 345                 350         

Arg Ala Leu Asp Lys Met Ala Asn Asp Ala Leu Ala Ser Gly Ser Pro 
        355                 360                 365             

Ala Asn His Pro Val Val Pro Ser His Glu Glu Ile Val Gln Leu Tyr 
    370                 375                 380                 

Arg Gln Ala Tyr Asp Ala Thr Trp Asp Ala Ala Pro Met Glu Ser Leu 
385                 390                 395                 400 

Thr Lys 
        

<210>   1373
<211>   1209
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1362

<400>   1373
gtgagcaggg tgtttggaga gttcaaagtc ccggaggctg tgtacgccgg gcgcggggcg       60

ctgcagatgc tgccgcaggc gtcgtccagc ctgggaaagc gggccctcat cgtgacggat      120

gaggtgatgg aacggctcgg ctacgtggca cagatgcaga ggatgttggc cgaggcgggc      180

gttcaagccg acgtgttcgc ggaggtgaac acggagccga ccgacgtgca cgtagagacc      240

ggcgtgcgcg cgttcttgca gcacggctgc gaccacctca tcgcgctcgg cgggggcagc      300

gccatcgacg ccgcgaaggg aatttccgtc atggcggtgc acgagggata catcggcgac      360

tatatgggcg gccgcaggac gttcgacaag gcgccgtacc ccgtgatcgc gatcccgacg      420

actgccggca cgggatccga ggtcaccagc gtaacggtta tcaccaatac caaggacgac      480

gtcaagatga tgatccggca acccgcgcta ttgcccaagg tcgcgatcgt ggacccccag      540

ctcaccgtct cgtcgcctcc ccatgtcacc gcttcgagcg gcgtggacgc gctgtgccac      600

gcgatcgagg cgtttatctc gagaagaagc catccgctga cggacgcgct ggccacggac      660

gctgcgaagc gtatagtgac ctacttggag cgggcgtaca acgacggaca ggacctggag      720

gcgcgcgagg ggatggcgat cgcggcgctg gaagctggca tggccttcac gaattcatcc      780

gtgtgcctcg tgcatggcat gtcccgcccc atcggcgcct tgtttcacgt accacatggt      840

tttgccaacg ccatgctcct tccgactgtg ctggagttcc gacttgatga ctacgcgccg      900

aggctggcgc tgctcgcgcg ggccctgaat ccagaactgt ccggtgcgtc ggacggcgaa      960

gccgcggcgt gggtcgtgag gcgagtgaaa acgcttgccg agaggctcca gatcccaaat     1020

ctcaagactt ggggaattga aagggatgcc ttcgagcgcg cgctggataa gatggcgaac     1080

gatgccctcg cgagtggcag cccagcgaac cacccggtcg tgccctcgca cgaggagatc     1140

gtccagctgt accggcaggc ctatgacgcc acgtgggatg cagcgccgat ggaatcgctt     1200

acaaaatga                                                             1209


<210>   1374
<211>   1209
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1362

<400>   1374
gtgagcaggg tgtttggaga gttcaaagtc ccggaggctg tgtacgccgg gcgcggggcg       60

ctgcagatgc tgccgcaggc gtcgtccagc ctgggaaagc gggccctcat cgtgacggat      120

gaggtgatgg aacggctcgg ctacgtggca cagatgcaga ggatgttggc cgaggcgggc      180

gttcaagccg acgtgttcgc ggaggtgaac acggagccga ccgacgtgca cgtagagacc      240

ggcgtgcgcg cgttcttgca gcacggctgc gaccacctca tcgcgctcgg cgggggcagc      300

gccatcgacg ccgcgaaggg aatttccgtc atggcggtgc acgagggata catcggcgac      360

tatatgggcg gccgcaggac gttcgacaag gcgccgtacc ccgtgatcgc gatcccgacg      420

actgccggca cgggatccga ggtcaccagc gtaacggtta tcaccaatac caaggacgac      480

gtcaagatga tgatccggca acccgcgcta ttgcccaagg tcgcgatcgt ggacccccag      540

ctcaccgtct cgtcgcctcc ccatgtcacc gcttcgagcg gcgtggacgc gctgtgccac      600

gcgatcgagg cgtttatctc gagaagaagc catccgctga cggacgcgct ggccacggac      660

gctgcgaaga agatagtgac ctacttggag cgggcgtaca acgacggaca ggacctggag      720

gcgcgcgagg ggatggcgat cgcggcgctg gaagctggca tggccttcac gaattcatcc      780

gtgtgcctcg tgcatggcat gtcccgcccc atcggcgcct tgtttcacgt accacatggt      840

tttgccaacg ccatgctcct tccgactgtg ctggagttcc gacttgatga ctacgcgccg      900

aggctggcgc tgctcgcgcg ggccctgaat ccagaactgt ccggtgcgtc ggacggcgaa      960

gccgcggcgt gggtcgtgag gcgagtgaaa acgcttgccg agaggctcca gatcccaaat     1020

ctcaagactt ggggaattga aagggatgcc ttcgagcgcg cgctggataa gatggcgaac     1080

gatgccctcg cgagtggcag cccagcgaac cacccggtcg tgccctcgca cgatgagatc     1140

gtccagctgt accggcaggc ctatgacgcc acgtgggatg cagcgccgat ggaatcgctt     1200

acaaaatga                                                             1209


<210>   1375
<211>   1209
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1362

<400>   1375
gtgagcaggg tgtttggaga gttcaaagtc ccggaggctg tgtacgccgg gcgcggggcg       60

ctgcagatgc tgccgcaggc gtcgtccagc ctgggaaagc gggccctcat cgtgacggat      120

gaggtgatgg aacggctcgg ctacgtggca cagatgcaga ggatgttggc cgaggcgggc      180

gttcaagccg acgtgttcgc ggaggtgaac acggagccga ccgacgtgca cgtagagacc      240

ggcgtgcgcg cgttcttgca gcacggctgc gaccacctca tcgcgctcgg cgggggcagc      300

gccatcgacg ccgcgaaggg aatttccgtc atggcggtgc acgagggata catcggcgac      360

tatatgggcg gccgcaggac gttcgacaag gcgccgtacc ccgtgatcgc gatcccgacg      420

actgccggca cgggatccga ggtcaccagc gtaacggtta tcaccaatac caaggacgac      480

gtcaagatga tgatccggca acccgcgcta ttgcccaagg tcgcgatcgt ggacccccag      540

ctcaccgtct cgtcgcctcc ccatgtcacc gcttcgagcg gcgtggacgc gctgtgccac      600

gcgatcgagg cgtttatctc gagaagaagc catccgctga cggacgcgct ggccacggac      660

gctgcgaaga agatagtgac ctacttggag cgggcgtaca acgacggaca ggacctggag      720

gcgcgcgagg ggatggcgat cgcggcgctg gaagctggca tggccttcac gaattcatcc      780

gtgtgcctcg tgcatggcat gtcccgcccc atcggcgcct tgtttcacgt accacatggt      840

tttgccaacg ccatgctcct tccgactgtg ctggagttcc gacttgatga ctacgcgccg      900

aggctggcga ttctcgcgcg ggccctgaat ccagaactgt ccggtgcgtc ggacggcgaa      960

gccgcggcgt gggtcgtgag gcgagtgaaa acgcttgccg agaggctcca gatcccaaat     1020

ctcaagactt ggggaattga aagggatgcc ttcgagcgcg cgctggataa gatggcgaac     1080

gatgccctcg cgagtggcag cccagcgaac cacccggtcg tgccctcgca cgaggagatc     1140

gtccagctgt accggcaggc ctatgacgcc acgtgggatg cagcgccgat ggaatcgctt     1200

acaaaatga                                                             1209


<210>   1376
<211>   1209
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1362

<400>   1376
gtgagcaggg tgtttggaga gttcaaagtc ccggaggctg tgtacgccgg gcgcggggcg       60

ctgcagatgc tgccgcaggc gtcgtccagc ctgggaaagc gggccctcat cgtgacggat      120

gaggtgatgg aacggctcgg ctacgtggca cagatgcaga ggatgttggc cgaggcgggc      180

gttaatgccg acgtgttcgc ggaggtgaac acggagccga ccgacgtgca cgtagagacc      240

ggcgtgcgcg cgttcttgca gcacggctgc gaccacctca tcgcgctcgg cgggggcagc      300

gccatcgacg ccgcgaaggg aatttccgtc atggcggtgc acgagggata catcggcgac      360

tatatgggcg gccgcaggac gttcgacaag gcgccgtacc ccgtgatcgc gatcccgacg      420

actgccggca cgggatccga ggtcaccagc gtaacggtta tcaccaatac caaggacgac      480

gtcaagatga tgatccggca acccgcgcta ttgcccaagg tcgcgatcgt ggacccccag      540

ctcaccgtct cgtcgcctcc ccatgtcacc gcttcgagcg gcgtggacgc gctgtgccac      600

gcgatcgagg cgtttatctc gagaagaagc catccgctga cggacgcgct ggccacggac      660

gctgcgaaga agatagtgac ctacttggag cgggcgtaca acgacggaca ggacctggag      720

gcgcgcgagg ggatggcgat cgcggcgctg gaagctggca tggccttcac gaattcatcc      780

gtgtgcctcg tgcatggcat gtcccgcccc atcggcgcct tgtttcacgt accacatggt      840

tttgccaacg ccatgctcct tccgactgtg ctggagttcc gacttgatga ctacgcgccg      900

aggctggcgc tgctcgcgcg ggccctgaat ccagaactgt ccggtgcgtc ggacggcgaa      960

gccgcggcgt gggtcgtgag gcgagtgaaa acgcttgccg agaggctcca gatcccaaat     1020

ctcaagactt ggggaattga aagggatgcc ttcgagcgcg cgctggataa gatggcgaac     1080

gatgccctcg cgagtggcag cccagcgaac cacccggtcg tgccctcgca cgaggagatc     1140

gtccagctgt accggcaggc ctatgacgcc acgtgggatg cagcgccgat ggaatcgctt     1200

acaaaatga                                                             1209


<210>   1377
<211>   1209
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1362

<400>   1377
gtgagcaggg tgtttggaga gttcaaagtc ccggaggctg tgtacgccgg gcgcggggcg       60

ctgcagatgc tgccgcaggc gtcgtccagc ctgggaaagc gggccctcat cgtgacggat      120

gaggtgatgg aacggctcgg ctacgtggca cagatgcaga ggatgttggc cgaggcgggc      180

gttcaagccg acgtgttcgc ggaggtgaac acggagccga ccgacgtgca cgtagagacc      240

ggcgtgcgcg cgttcttgca gcacggctgc gaccacctca tcgcgctcgg cgggggcagc      300

gccatcgacg ccgcgaaggg aatttccgtc atggcggtgc acgagggata catcggcgac      360

tatatgggcg gccgcaggac gttcgaaaag gcgccgtacc ccgtgatcgc gatcccgacg      420

actgccggca cgggatccga ggtcaccagc gtaacggtta tcaccaatac caaggacgac      480

gtcaagatga tgatccggca acccgcgcta ttgcccaagg tcgcgatcgt ggacccccag      540

ctcaccgtct cgtcgcctcc ccatgtcacc gcttcgagcg gcgtggacgc gctgtgccac      600

gcgatcgagg cgtttatctc gagaagaagc catccgctga cggacgcgct ggccacggac      660

gctgcgaaga agatagtgac ctacttggag cgggcgtaca acgacggaca ggacctggag      720

gcgcgcgagg ggatggcgat cgcggcgctg gaagctggca tggccttcac gaattcatcc      780

gtgtgcctcg tgcatggcat gtcccgcccc atcggcgcct tgtttcacgt accacatggt      840

tttgccaacg ccatgctcct tccgactgtg ctggagttcc gacttgatga ctacgcgccg      900

aggctggcgc tgctcgcgcg ggccctgaat ccagaactgt ccggtgcgtc ggacggcgaa      960

gccgcggcgt gggtcgtgag gcgagtgaaa acgcttgccg agaggctcca gatcccaaat     1020

ctcaagactt ggggaattga aagggatgcc ttcgagcgcg cgctggataa gatggcgaac     1080

gatgccctcg cgagtggcag cccagcgaac cacccggtcg tgccctcgca cgaggagatc     1140

gtccagctgt accggcaggc ctatgacgcc acgtgggatg cagcgccgat ggaatcgctt     1200

acaaaatga                                                             1209


<210>   1378
<211>   534
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1378
Met Val Arg Glu Asn Met Ala Thr Lys Ile Leu Val Thr Asp Asp Ile 
                5                   10                  15      

Ser Gln Ala Gly Ile Asp Ile Leu Ser Gly Leu Gln Gly Ala Glu Val 
            20                  25                  30          

Val Val Arg Thr Asn Leu Ala Pro Asp Glu Leu Lys Glu Ala Ile Ala 
        35                  40                  45              

Asp Ala Asp Ala Leu Val Val Arg Ser Gln Thr Arg Val Thr Arg Asp 
    50                  55                  60                  

Val Ile Glu Ser Ala Lys Lys Leu Lys Val Ile Gly Arg Ala Gly Val 
65                  70                  75                  80  

Gly Val Asp Asn Ile Asp Leu Glu Ala Ala Thr Arg Arg Gly Ile Leu 
                85                  90                  95      

Val Ile Asn Ala Pro Asp Gly Asn Thr Ile Ala Ala Ala Glu His Thr 
            100                 105                 110         

Phe Ala Met Met Ile Ser Leu Ala Arg His Ile Pro Ala Ala His Arg 
        115                 120                 125             

Asp Leu Leu Gln Gly Asn Trp Asn Arg Lys Lys Trp Ile Gly Val Glu 
    130                 135                 140                 

Leu Arg Gly Lys Thr Leu Ala Val Leu Gly Met Gly Arg Ile Gly Thr 
145                 150                 155                 160 

Glu Val Ala Lys Arg Ala Lys Ala Phe Gly Met Thr Val Leu Gly Tyr 
                165                 170                 175     

Asp Pro Phe Leu Thr Glu Glu Arg Ala Gln Ser Leu Gly Val Lys Arg 
            180                 185                 190         

Cys Asp Leu Asp Thr Ala Ile Arg Glu Ala Asp Phe Ile Thr Val His 
        195                 200                 205             

Thr Pro Leu Thr Lys Glu Thr His His Met Ile Asp Ala Gly Arg Ile 
    210                 215                 220                 

Ala Gln Met Lys Glu Gly Val Arg Ile Ile Asn Cys Ala Arg Gly Gly 
225                 230                 235                 240 

Ile Ile Asp Glu Val Ala Leu Ala Glu Ala Leu Glu Ala Gly Arg Val 
                245                 250                 255     

Ala Gly Ala Ala Ile Asp Val Phe Glu Gln Glu Pro Leu Pro Met Asp 
            260                 265                 270         

His Pro Leu Arg Arg Cys Pro Asn Val Val Leu Thr Pro His Leu Gly 
        275                 280                 285             

Ala Ser Thr Val Glu Ala Gln Glu Asn Val Ala Ile Gln Val Ala Glu 
    290                 295                 300                 

Glu Ile Val Gln Val Leu Arg Asp Asp Thr Phe Glu His Ala Val Asn 
305                 310                 315                 320 

Leu Pro Ser Leu Ser Gln Arg Gln Lys Glu Arg Leu Ala Pro Tyr Leu 
                325                 330                 335     

Ala Leu Ala Glu Gln Leu Gly Leu Phe Ala Ala Gln Leu Ala Gln Gly 
            340                 345                 350         

Ala Pro Ser Ser Met Thr Val Arg Tyr Ala Gly Asp Ala Ala Asp Pro 
        355                 360                 365             

Asp Gly Gly Tyr Leu Thr Arg Thr Val Leu Lys Gly Phe Phe Ser Phe 
    370                 375                 380                 

Gln Tyr Asn Gly Glu Val Asn Tyr Val Asn Ala Leu Arg Tyr Ala Glu 
385                 390                 395                 400 

Asp Ala Gly Leu Arg Val Gln Glu Val Arg Glu Ser Arg Gly Arg Val 
                405                 410                 415     

Tyr Thr Asn Glu Val Glu Ile Ser Val Ala Thr Asp Asn Gly Thr His 
            420                 425                 430         

Arg Val Thr Gly Thr Val Leu Gly Glu Tyr Gly Pro Arg Ile Val Glu 
        435                 440                 445             

Leu Asp Gly Tyr Pro Ile Asp Thr Pro Ile Gln Gly Ile Leu Ile Tyr 
    450                 455                 460                 

Thr Arg His Glu Asp Arg Pro Gly Met Ile Gly Arg Ile Gly Thr Leu 
465                 470                 475                 480 

Leu Gly Asp Arg Asp Ile Asn Ile Ala Gly Met Gln Val Gly Arg Arg 
                485                 490                 495     

Glu Thr Gly Gly Glu Ala Val Met Leu Leu Ser Val Asp Lys Arg Val 
            500                 505                 510         

Pro Gln Asp Val Ile Asp Glu Ile Ala Lys His Pro Gly Ile Arg Leu 
        515                 520                 525             

Val Arg Ala Ile Glu Leu 
    530                 

<210>   1379
<211>   1605
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1379
gtggtgagag agaacatggc gaccaagatt ttggtgacgg acgacatctc ccaggcgggc       60

atcgacatcc tctccggcct tcagggcgcg gaggtcgtgg tcaggacgaa tctcgcgccg      120

gacgagctga aggaggccat tgccgacgcg gacgcccttg tggtgcgctc gcagacgcgc      180

gtgacgaggg acgtgatcga gagcgcgaaa aagctcaagg tcatcggccg cgcgggcgtc      240

ggcgtcgaca acatcgatct tgaggcggcc acgcgccgcg gcatcctggt catcaacgcc      300

ccagatggca acaccattgc ggcggcggag cacaccttcg cgatgatgat cagccttgcg      360

cggcacatcc ccgcggctca tcgggatctc ctccagggca actggaatcg caagaagtgg      420

attggcgtcg agcttcgcgg caagacgctg gcggtcctcg gcatgggccg catcggcacg      480

gaggtcgcga agcgggcgaa ggcgttcggc atgactgtcc tcgggtatga tccgttcctg      540

acggaggagc gcgcgcagag cctcggcgtc aagcggtgcg atctcgacac cgccatccgc      600

gaggccgact tcatcaccgt gcacacgccg ctgacgaaag agacgcatca catgattgat      660

gccggccgga tcgcccagat gaaggagggc gtgcggatca tcaactgcgc gcgcggcggc      720

atcatcgacg aggtggcgct cgcggaggcg ctcgaggcgg ggcgcgtggc gggcgccgcc      780

atcgacgtgt ttgagcagga gccgctgccg atggatcacc cgctcaggcg ctgcccgaac      840

gtcgtgttga cgccgcacct cggcgcgtcg acggtggagg cgcaggagaa cgtggcgatt      900

caagtggcgg aggaaatcgt gcaggtgctt cgcgacgaca ccttcgagca cgcggtcaac      960

ctgccgagcc tgagccagcg ccagaaggag cggctcgcgc cttatctcgc ccttgcggag     1020

caactggggc tgtttgcggc gcagctcgcg cagggcgcgc cctcgagcat gaccgtgcgc     1080

tacgccggtg acgcggccga tccagacggc ggctacctca cccgcacggt gctgaagggc     1140

ttcttcagct tccagtacaa cggcgaggtc aactacgtca acgcgctgcg gtacgcggaa     1200

gacgcgggcc tgcgtgtgca ggaggtgcgc gagtcgcgcg gccgggtgta cacgaacgag     1260

gtggagatct cggtcgcgac ggacaacggc acgcaccgcg tgacgggcac ggtcctcggg     1320

gagtacgggc cgcgcatcgt cgagctcgac gggtacccca ttgacacgcc cattcaaggc     1380

atcctcatct acacgcggca cgaggaccgt cccggcatga tcggccgcat cggcacgcta     1440

cttggcgatc gcgacatcaa cattgccggc atgcaggtgg gccggcggga gacgggcgga     1500

gaagcggtga tgctcctgtc cgtcgacaag cgcgtgccgc aggacgtgat cgacgaaatc     1560

gcgaagcatc cgggcattcg actggtcagg gccatcgagc tgtga                     1605


<210>   1380
<211>   524
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   1380
Ile Leu Val Thr Asp Lys Val Ser Glu Glu Gly Leu Lys Lys Leu Tyr 
                5                   10                  15      

Ala His Lys Asp Phe Ile Val Glu His Gln Pro Gly Ile Ala Pro Glu 
            20                  25                  30          

Asp Leu Lys Ala Thr Ile Gly Gln Tyr Asp Gly Leu Ile Val Arg Asn 
        35                  40                  45              

Gln Thr Lys Val Thr Lys Asp Ile Ile Glu Ala Ser Gly Asn Leu Arg 
    50                  55                  60                  

Val Ile Ala Arg Ala Gly Val Gly Val Asp Asn Ile Asp Val Asp Ala 
65                  70                  75                  80  

Ala Thr Arg Lys Gly Ile Ile Val Val Asn Ser Pro Gly Gly Asn Thr 
                85                  90                  95      

Ile Ser Ala Thr Glu His Thr Leu Ala Met Met Leu Ser Leu Ser Arg 
            100                 105                 110         

Asn Ile Pro Gln Ala His Lys Ser Ala Ala Ala Gly Lys Trp Glu Arg 
        115                 120                 125             

Glu Lys Phe Lys Gly Val Glu Leu Phe Lys Lys Thr Leu Gly Ile Ile 
    130                 135                 140                 

Gly Thr Gly Lys Ile Gly Thr Glu Val Ala Lys Arg Ala Lys Ala Phe 
145                 150                 155                 160 

Gly Met Ala Val Leu Gly Tyr Asp Pro Tyr Leu Thr Glu Glu Arg Ala 
                165                 170                 175     

Ala Lys Leu Gly Ile Lys Lys Ala Thr Leu Asp Glu Ile Ala Ala Gln 
            180                 185                 190         

Ala Asp Phe Ile Thr Leu His Thr Pro Leu Met Lys Glu Thr Lys His 
        195                 200                 205             

Leu Ile Asn Glu Ala Phe Leu Ala Lys Thr Lys Lys Gly Val Arg Ile 
    210                 215                 220                 

Ile Asn Cys Ala Arg Gly Gly Leu Val Asp Glu Gln Ala Leu Leu Gln 
225                 230                 235                 240 

Ala Leu Gln Glu Gly Arg Val Ala Gly Ala Ala Leu Asp Val Phe Glu 
                245                 250                 255     

Asn Glu Pro Asp Ile Thr Pro Gly Leu Leu Glu Leu Pro Asn Val Thr 
            260                 265                 270         

Val Thr Pro His Leu Gly Ala Ser Thr Arg Glu Ala Gln Val Arg Val 
        275                 280                 285             

Ala Ala Asp Val Ser Asp Glu Ile Ile His Ile Phe Glu Ser Glu Glu 
    290                 295                 300                 

Ile Arg Asn Ala Ile Asn Met Pro Gln Thr Ser Gly Glu Asn Arg Glu 
305                 310                 315                 320 

Arg Met Glu Pro Phe Leu Leu Leu Gly Glu Gln Val Ala Gln Leu Gly 
                325                 330                 335     

Ile Gln Leu Leu Asp Glu Ala Pro Glu Lys Ile Glu Ile Thr Tyr Ala 
            340                 345                 350         

Gly Glu Leu Leu Asp Glu Asp Thr Lys Leu Leu Thr Arg Thr Ile Ile 
        355                 360                 365             

Lys Gly Ile Leu Ala Arg His Leu Gly Ser Thr Val Asn Leu Val Asn 
    370                 375                 380                 

Ala Leu His Leu Leu Lys Glu Gln Gly Leu Thr Tyr Asn Leu Gln Arg 
385                 390                 395                 400 

Asn Ala Ala Phe Lys Gly Phe Ser Asn Tyr Leu Glu Leu Ala Leu Tyr 
                405                 410                 415     

Lys Lys Gly Lys Gln Val Asn Ile Gly Ala Ser Ile Ile Asn Gly Phe 
            420                 425                 430         

Gly Gly Arg Ile Val Lys Leu Asn Asp Tyr Arg Val Asp Leu Arg Pro 
        435                 440                 445             

Glu Gln His Leu Leu Tyr Ile Arg His Leu Asp Ile Pro Gly Met Ile 
    450                 455                 460                 

Gly Gln Val Gly Ser Ile Leu Gly Ser Asn Asp Thr Asn Ile Gly Thr 
465                 470                 475                 480 

Met Gln Val Gly Arg Lys Glu Ile Gly Gly Glu Ala Ile Met Val Leu 
                485                 490                 495     

Thr Leu Asp Lys Thr Ala Ser Arg Gln Val Leu Asp Gln Leu Lys Glu 
            500                 505                 510         

Val Ile Gly Ile Lys Ala Val Gln Thr Leu Glu Leu 
        515                 520                 

<210>   1381
<211>   525
<212>   PRT
<213>   Trichodesmium erythraeum IMS101

<400>   1381
Lys Val Leu Val Ser Asp Ser Ile Asp Gln Asn Gly Ile Asn Ile Leu 
                5                   10                  15      

Ser Gln Val Ala Gln Val Asp Ile Lys Ile Gly Leu Pro Val Glu Glu 
            20                  25                  30          

Leu Val Lys Ile Ile Pro Glu Tyr Asp Gly Leu Met Ile Arg Ser Gly 
        35                  40                  45              

Thr Lys Val Thr Lys Glu Ile Ile Glu Ala Ala Asp Lys Leu Lys Ile 
    50                  55                  60                  

Ile Gly Arg Ala Gly Val Gly Val Asp Asn Val Asp Val Gln Ala Ala 
65                  70                  75                  80  

Thr Arg Lys Gly Ile Val Val Val Asn Ser Pro Glu Gly Asn Thr Ile 
                85                  90                  95      

Ala Ala Ala Glu His Ala Leu Ala Met Met Leu Ser Met Ser Arg His 
            100                 105                 110         

Val Pro Glu Ala Asn Gln Ser Ile Ile Asn Ala Gln Trp Asp Arg Lys 
        115                 120                 125             

Lys Phe Val Gly Val Glu Val Tyr Lys Lys Thr Leu Gly Val Val Gly 
    130                 135                 140                 

Leu Gly Lys Ile Gly Ser His Val Ala Lys Val Ala Lys Ala Met Gly 
145                 150                 155                 160 

Met Lys Ile Leu Ala Tyr Asp Pro Phe Ile Ser Glu Glu Arg Ala Glu 
                165                 170                 175     

Gln Leu Gly Cys Ser Leu Val Asp Leu Asp Leu Leu Val Gln Glu Ser 
            180                 185                 190         

Asp Tyr Ile Thr Leu His Ile Pro Lys Thr Asp Glu Thr Tyr His Ser 
        195                 200                 205             

Ile Asn Ala Glu Thr Phe Ala Lys Met Lys Pro Thr Ala Arg Ile Ile 
    210                 215                 220                 

Asn Cys Ser Arg Gly Gly Ile Ile Asp Glu Val Ala Leu Ser Lys Ala 
225                 230                 235                 240 

Leu Lys Glu Gly Lys Ile Ala Gly Ala Ala Leu Asp Val Tyr Glu Asn 
                245                 250                 255     

Glu Pro Leu Glu Val Glu Ser Pro Leu Arg Asp Leu Gly Gln Lys Ile 
            260                 265                 270         

Val Met Thr Pro His Leu Gly Ala Ser Thr Ala Glu Ala Gln Val Asn 
        275                 280                 285             

Val Ala Ile Asp Val Ala Glu Gln Ile Arg Asp Val Leu Leu Gly Leu 
    290                 295                 300                 

Pro Ala Arg Ser Ala Val Asn Ile Pro Gly Met Tyr Pro Asp Thr Leu 
305                 310                 315                 320 

Lys Lys Leu Lys Pro Tyr Leu Arg Leu Ala Glu Thr Leu Gly Asn Leu 
                325                 330                 335     

Val Ser Gln Leu Ala Gly Gly Arg Ile Asp Phe Leu Asn Val Arg Leu 
            340                 345                 350         

Glu Gly Asp Leu Ala Gly Gly Asp Ser Lys Pro Val Val Val Gly Ala 
        355                 360                 365             

Leu Lys Gly Leu Leu Ser Gln Ala Leu Arg Glu Arg Val Asn Tyr Val 
    370                 375                 380                 

Asn Ala Phe Ile Glu Ala Lys Glu Arg Gly Ile Arg Val Val Glu Thr 
385                 390                 395                 400 

Arg Asp Asp Ser Val Arg Asp Tyr Thr Gly Ser Leu His Leu Glu Ala 
                405                 410                 415     

Lys Gly Ser Leu Gly Glu His Asn Val Arg Gly Ser Leu Leu Gly Lys 
            420                 425                 430         

Asp Glu Ile Arg Ile Thr Asn Ile Asp Gly Phe Pro Ile Asn Val Pro 
        435                 440                 445             

Pro Ser Pro Tyr Met Leu Leu Thr Leu His Arg Asp Met Pro Gly Ile 
    450                 455                 460                 

Ile Gly Lys Ile Gly Ser Leu Leu Gly Ser Phe Asn Val Asn Ile Ala 
465                 470                 475                 480 

Ser Met Gln Val Gly Arg Lys Ile Val Arg Gly Asp Ala Val Met Val 
                485                 490                 495     

Leu Ser Val Asp Asp Pro Leu Pro Glu Glu Ile Leu Thr Glu Ile Leu 
            500                 505                 510         

Lys Glu Pro Gly Ile Arg Asn Ala Tyr Thr Val Ala Leu 
        515                 520                 525 

<210>   1382
<211>   511
<212>   PRT
<213>   uncultured methanogenic archaeon RC-I

<400>   1382
Lys Val Leu Val Thr Asp Pro Ile Ser Glu Glu Gly Ile Lys Ile Leu 
                5                   10                  15      

Lys Ser Glu Pro Gly Val Gln Val Asp Ile Glu Thr Arg Leu Thr Lys 
            20                  25                  30          

Glu Gln Leu Ile Glu Lys Ile Lys Asp Tyr Asn Ala Leu Ile Ile Arg 
        35                  40                  45              

Ser Glu Thr Gln Val Thr Lys Glu Val Ile Ala Ala Gly Lys Asn Leu 
    50                  55                  60                  

Lys Ile Ile Gly Arg Ala Gly Val Gly Ile Asp Asn Val Asp Val Pro 
65                  70                  75                  80  

Ala Ala Thr Glu Lys Gly Ile Ile Val Ala Asn Ala Pro Glu Gly Asn 
                85                  90                  95      

Thr Ile Ala Ala Cys Glu His Thr Leu Ser Met Met Leu Ala Met Ser 
            100                 105                 110         

Arg Asn Ile Pro Gln Ala Asn Ala Ser Leu Lys Ser Gly Lys Trp Glu 
        115                 120                 125             

Arg Ser Lys Phe Met Gly Val Glu Val Met Asn Lys Thr Leu Gly Ile 
    130                 135                 140                 

Ile Gly Leu Gly Arg Ile Gly Gly Glu Ile Thr Lys Arg Ala Arg Ser 
145                 150                 155                 160 

Phe Gly Met Glu Val Leu Ala Tyr Asp Pro Phe Thr Thr Ala Glu Arg 
                165                 170                 175     

Ala Gln Gln Ile Gly Ala Arg Leu Thr Thr Leu Asp Glu Ile Tyr Glu 
            180                 185                 190         

Lys Ala Asp Phe Ile Thr Val His Thr Pro Leu Thr Pro Ser Thr Lys 
        195                 200                 205             

His Met Val Ser Thr Ala Gln Phe Glu Lys Met Lys Lys Gly Val Arg 
    210                 215                 220                 

Ile Ile Asn Cys Ala Arg Gly Gly Ile Ile Asp Glu Ala Ala Leu Leu 
225                 230                 235                 240 

Glu Ala Ile Lys Ser Gly Lys Val Ala Gly Ala Ala Leu Asp Val Phe 
                245                 250                 255     

Glu Lys Glu Pro Pro Val Gly Ser Pro Leu Leu Glu Gln Pro Asn Ile 
            260                 265                 270         

Ile Val Thr Pro His Leu Gly Ala Ser Thr Ala Glu Ala Gln Ile Asn 
        275                 280                 285             

Val Ala Ile Thr Ile Ala Glu Gln Val Leu Asn Ala Phe Lys Gly Leu 
    290                 295                 300                 

Pro Val Thr Thr Ala Ile Asn Ile Pro Ile Met Lys Pro Glu Val Met 
305                 310                 315                 320 

Glu Lys Val Lys Pro Phe Leu Pro Leu Ala Glu Gln Leu Gly Lys Phe 
                325                 330                 335     

Ala Ala Gln Ile Thr Asp Gly Gln Ile Lys Glu Ala Ile Val Ser Tyr 
            340                 345                 350         

Asn Gly Glu Ile Ala Gln Lys Asp Val Thr Leu Val Thr Val Ala Val 
        355                 360                 365             

Leu Lys Gly Leu Leu Asp Val Lys Leu Gly Glu Pro Val Asn Tyr Val 
    370                 375                 380                 

Asn Ala Lys His Ile Ala Lys Asp Arg Ser Ile Asn Val Ala Glu Thr 
385                 390                 395                 400 

Lys Leu Ala Glu Thr Gly Asp Tyr Thr Asn Leu Ile Thr Leu Thr Leu 
                405                 410                 415     

Lys Thr Asp Lys Gly Glu Thr Arg Val Ser Gly Thr Ile Phe Gly Lys 
            420                 425                 430         

Ser Asp Ala Arg Ile Val Glu Ile Gln Gly Tyr Arg Val Asp Ala Val 
        435                 440                 445             

Pro Ser Gly Thr Met Ile Val Thr Arg His Gln Asp Arg Pro Gly Val 
    450                 455                 460                 

Ile Gly Lys Val Gly Met Ile Leu Gly Lys Leu Asn Ile Asn Ile Ser 
465                 470                 475                 480 

Gly Met Val Val Gly Arg Asp Ala Val Arg Gly Asp Ala Val Met Ile 
                485                 490                 495     

Leu Thr Val Asp Asp Glu Val Pro Ala Ala Thr Leu Lys Gln Met 
            500                 505                 510     

<210>   1383
<211>   525
<212>   PRT
<213>   Desulfotomaculum reducens MI-1

<400>   1383
Lys Val Leu Val Met Asp Gly Val Ser Glu Gln Gly Leu Ala Pro Leu 
                5                   10                  15      

Arg Gln His Thr Asp Ile Glu Val Val Ile Gly Glu Lys Met Thr Glu 
            20                  25                  30          

Asp Gln Leu Val Glu Val Ile Gly Glu Tyr Asp Ala Met Ile Val Arg 
        35                  40                  45              

Ser Ala Thr Lys Val Thr Pro Arg Val Val Glu Ala Ala Lys Lys Leu 
    50                  55                  60                  

Lys Val Ile Gly Arg Ala Gly Val Gly Val Asp Asn Ile Asp Arg Asn 
65                  70                  75                  80  

Ala Ala Thr Asn Lys Gly Ile Val Val Val Asn Ala Pro Asp Gly Asn 
                85                  90                  95      

Thr Ile Ala Ala Ala Glu His Thr Met Ala Met Met Leu Gly Leu Ala 
            100                 105                 110         

Arg Lys Val Pro Ala Ala Cys Gly Lys Leu Lys Asn Gly Ile Trp Asp 
        115                 120                 125             

Lys Lys Ala Phe Leu Gly Val Glu Leu Arg Gly Lys Thr Leu Gly Val 
    130                 135                 140                 

Ile Gly Leu Gly Arg Ile Gly Thr Ala Val Ala Lys Arg Ala Gln Ala 
145                 150                 155                 160 

Met Glu Met Asn Ile Val Ala Tyr Asp Pro Tyr Ile Ser Glu Asp His 
                165                 170                 175     

Ala Arg Lys Met Ala Val Glu Ile Val Thr Leu Gln Glu Leu Phe Lys 
            180                 185                 190         

Arg Ala Asp Phe Ile Thr Ile His Met Pro Lys Thr Lys Glu Thr Tyr 
        195                 200                 205             

His Met Ile Asn Glu Glu Ala Leu Glu Leu Met Lys Asp Gly Val Arg 
    210                 215                 220                 

Ile Ile Asn Cys Ala Arg Gly Gly Ile Val Asp Glu Glu Ala Leu Tyr 
225                 230                 235                 240 

Lys Phe Met Glu Ala Gly Lys Val Ala Gly Ala Ala Leu Asp Val Phe 
                245                 250                 255     

Glu Thr Glu Pro Cys Thr Asp Asn Pro Leu Leu Lys Leu Asp Asn Phe 
            260                 265                 270         

Ile Ala Thr Pro His Leu Gly Ala Ser Thr Gln Glu Ala Gln Ile Asn 
        275                 280                 285             

Val Ala Val Asp Val Ala Glu Glu Ile Val Ala Ala Leu Arg Gly Asp 
    290                 295                 300                 

Leu Val Lys Asn Ala Val Asn Met Pro Ser Met Ser Pro Lys Leu Leu 
305                 310                 315                 320 

Ala Lys Ile Arg Pro Phe Leu Asp Leu Ala Glu Lys Leu Gly Thr Phe 
                325                 330                 335     

Gln Ala Gln Met Leu Asp Gly Arg Ile Glu Lys Val Glu Val Val Tyr 
            340                 345                 350         

Ser Gly Glu Leu Ala Lys Tyr Asp Val Asn Pro Val Thr Thr Ile Leu 
        355                 360                 365             

Leu Lys Gly Leu Leu Asp Pro Ile Leu Gln Glu Asn Val Asn Phe Val 
    370                 375                 380                 

Asn Ala Thr Leu Val Ala Arg Asn Arg Gly Ile Ser Val Val Gln Thr 
385                 390                 395                 400 

Thr Lys Glu Asn Gly Glu Asp Tyr His Asn Leu Ile Thr Val Tyr Ile 
                405                 410                 415     

Tyr Thr Asp Lys Gly Arg Arg Met Leu Ser Gly Thr Leu Phe Gln Gly 
            420                 425                 430         

Asn Asp Pro Arg Ile Val Asn Ile Asp Gly Phe Arg Ile Asn Ala Ala 
        435                 440                 445             

Thr Gln Gly His Met Leu Val Val Pro His Ile Asp Lys Pro Gly Ile 
    450                 455                 460                 

Val Gly Lys Val Gly Thr Val Val Gly Asp Met Ala Ile Asn Ile Ala 
465                 470                 475                 480 

Gly Met Gln Val Gly Arg Ile Glu Leu Gly Gly Lys Ala Ile Met Val 
                485                 490                 495     

Met Met Val Asp Asn Thr Leu Pro Thr Asn Ala Leu Glu Gln Leu Ala 
            500                 505                 510         

Thr Ile Asp Gly Ile Leu Glu Val Lys Met Val Ser Leu 
        515                 520                 525 

<210>   1384
<211>   518
<212>   PRT
<213>   Lyngbya sp. PCC 8106

<400>   1384
Lys Val Leu Val Ser Asp Ser Ile Asp Pro Ala Gly Ile Asp Ile Leu 
                5                   10                  15      

Ser Gln Val Ala Gln Val Asp Val Lys Thr Gly Leu Pro Ala Glu Glu 
            20                  25                  30          

Leu Val Lys Ile Ile Ser Glu Tyr Asp Ala Leu Met Ile Arg Ser Gly 
        35                  40                  45              

Thr Arg Val Thr Gln Glu Ile Ile Glu Ala Gly Val Gln Leu Lys Ile 
    50                  55                  60                  

Ile Gly Arg Ala Gly Val Gly Val Asp Asn Val Asp Val Ala Ala Ala 
65                  70                  75                  80  

Thr Arg Ala Gly Ile Val Val Val Asn Ser Pro Glu Gly Asn Thr Ile 
                85                  90                  95      

Ala Ala Ala Glu His Ala Leu Ala Met Met Leu Ser Leu Ser Arg Tyr 
            100                 105                 110         

Ile Pro Glu Ala Asn Gln Ser Val Lys Ser Gly Lys Trp Asp Arg Lys 
        115                 120                 125             

Lys Phe Ile Gly Val Glu Val Tyr Lys Lys Thr Leu Gly Ile Val Gly 
    130                 135                 140                 

Leu Gly Lys Ile Gly Ser His Val Ala Ala Ala Ala Lys Ala Met Gly 
145                 150                 155                 160 

Met Lys Leu Leu Ala Phe Asp Pro Tyr Ile Ser Gln Glu Arg Ala Asp 
                165                 170                 175     

Gln Leu Ser Cys Arg Leu Val Asp Leu Glu Leu Leu Leu Gln Glu Ser 
            180                 185                 190         

Asp Tyr Ile Thr Leu His Met Pro Lys Thr Lys Asp Thr Tyr His Met 
        195                 200                 205             

Ile Asp Ala Lys Ala Phe Glu Lys Met Lys Pro Thr Ala Arg Ile Ile 
    210                 215                 220                 

Asn Cys Ala Arg Gly Gly Ile Ile Asp Glu Ala Ala Leu Val Glu Ala 
225                 230                 235                 240 

Leu Lys Gln Gly Gln Ile Ala Gly Ala Ala Ile Asp Val Tyr Glu Asn 
                245                 250                 255     

Glu Pro Leu Glu Ala Glu Ser Pro Leu Arg Ala Leu Asp Gln Lys Leu 
            260                 265                 270         

Val Leu Thr Pro His Leu Gly Ala Ser Thr Glu Glu Ala Gln Val Asn 
        275                 280                 285             

Val Ala Val Asp Val Ala Glu Gln Ile Arg Asp Val Leu Leu Gly Leu 
    290                 295                 300                 

Pro Ala Arg Ser Ala Val Asn Ile Pro Gly Leu Tyr Pro Asp Ala Leu 
305                 310                 315                 320 

Glu Lys Leu Lys Pro Tyr Leu Gln Leu Ala Glu Thr Leu Gly Asn Leu 
                325                 330                 335     

Val Ser Gln Leu Ala Gly Gly Arg Val Asp Phe Leu Asp Val Arg Leu 
            340                 345                 350         

Gln Gly Glu Leu Ala Thr Asn Asn Ser Gln Pro Val Val Val Ala Ser 
        355                 360                 365             

Leu Lys Gly Leu Leu Ser Gln Ala Leu Arg Glu Arg Val Asn Tyr Val 
    370                 375                 380                 

Asn Ala Ser Ile Glu Ala Lys Glu Arg Gly Ile His Val Ile Glu Thr 
385                 390                 395                 400 

Arg Asp Ala Ser Ala Asn Asp Tyr Thr Gly Ser Leu His Leu Glu Ala 
                405                 410                 415     

Lys Gly Ser Leu Gly Thr His Ser Val Thr Gly Ala Leu Leu Gly Ser 
            420                 425                 430         

Ser Glu Met Arg Ile Thr Asn Ile Asp Gly Phe Pro Ile Asn Val Pro 
        435                 440                 445             

Pro Thr His His Met Leu Phe Thr Leu His Arg Asp Met Pro Gly Ile 
    450                 455                 460                 

Ile Gly Lys Ile Gly Ser Leu Leu Gly Ser Phe Asn Val Asn Ile Ala 
465                 470                 475                 480 

Ser Met Gln Val Gly Arg Lys Ile Val Arg Gly Glu Ala Val Met Val 
                485                 490                 495     

Leu Ser Ile Asp Asp Pro Leu Pro Glu Gly Leu Leu Ser Glu Ile Met 
            500                 505                 510         

Lys Val Pro Gly Ile Arg 
        515             

<210>   1385
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1378

<400>   1385
Met Val Arg Glu Asn Met Ala Thr Lys Ile Leu Val Thr Asp Asp Ile 
                5                   10                  15      

Ser Gln Ala Gly Ile Asp Ile Leu Ser Gly Leu Gln Gly Ala Glu Val 
            20                  25                  30          

Val Val Arg Thr Asn Leu Ala Pro Asp Glu Leu Lys Glu Ala Ile Ala 
        35                  40                  45              

Asp Ala Asp Ala Leu Val Val Arg Ser Gln Thr Arg Val Thr Arg Asp 
    50                  55                  60                  

Val Ile Glu Ser Ala Lys Lys Leu Lys Val Ile Gly Arg Ala Gly Val 
65                  70                  75                  80  

Gly Val Asp Asn Ile Asp Leu Glu Ala Ala Thr Arg Arg Gly Ile Leu 
                85                  90                  95      

Val Ile Asn Ala Pro Asp Gly Asn Thr Ile Ala Ala Ala Glu His Thr 
            100                 105                 110         

Phe Ala Met Met Ile Ser Leu Ala Arg His Ile Pro Ala Ala His Arg 
        115                 120                 125             

Asp Leu Leu Gln Gly Asn Trp Asn Arg Lys Lys Trp Ile Gly Val Glu 
    130                 135                 140                 

Leu Arg Gly Lys Thr Leu Ala Val Leu Gly Met Gly Arg Ile Gly Thr 
145                 150                 155                 160 

Glu Val Ala Lys Arg Ala Lys Ala Phe Gly Met Thr Val Leu Gly Tyr 
                165                 170                 175     

Asp Pro Phe Leu Thr Glu Glu Arg Ala Gln Ser Leu Gly Val Lys Arg 
            180                 185                 190         

Cys Asp Leu Asp Thr Ala Ile Arg Glu Ala Asp Phe Ile Thr Val His 
        195                 200                 205             

Thr Pro Leu Thr Lys Glu Thr His His Met Ile Asp Ala Gly Arg Ile 
    210                 215                 220                 

Ala Gln Met Lys Glu Gly Val Arg Ile Ile Asn Cys Ala Arg Gly Gly 
225                 230                 235                 240 

Ile Ile Asp Glu Val Ala Leu Ala Glu Ala Leu Glu Ala Gly Arg Val 
                245                 250                 255     

Ala Gly Ala Ala Ile Asp Val Phe Glu Gln Glu Pro Leu Pro Met Asp 
            260                 265                 270         

His Pro Leu Arg Arg Cys Pro Asn Val Val Leu Thr Pro His Leu Gly 
        275                 280                 285             

Ala Ser Thr Val Glu Ala Gln Glu Asn Val Ala Ile Gln Val Ala Glu 
    290                 295                 300                 

Glu Ile Val Gln Val Leu Arg Asp Asp Thr Phe Glu His Ala Val Asn 
305                 310                 315                 320 

Leu Pro Ser Leu Ser Gln Arg Gln Lys Glu Arg Leu Ala Pro Tyr Leu 
                325                 330                 335     

Ala Leu Ala Glu Gln Leu Gly Leu Phe Ala Ala Gln Leu Ala Gln Gly 
            340                 345                 350         

Ala Pro Ser Ser Met Thr Val Arg Tyr Ala Gly Asp Ala Ala Asp Pro 
        355                 360                 365             

Asp Gly Gly Tyr Leu Thr Arg Thr Val Leu Lys Gly Phe Phe Ser Phe 
    370                 375                 380                 

Gln Tyr Asn Gly Glu Val Asn Tyr Val Asn Ala Leu Arg Tyr Ala Glu 
385                 390                 395                 400 

Asp Ala Gly Leu Arg Val Gln Glu Val Arg Glu Ser Arg Gly Arg Val 
                405                 410                 415     

Tyr Thr Asn Asp Val Glu Ile Ser Val Ala Thr Asp Asn Gly Thr His 
            420                 425                 430         

Arg Val Thr Gly Thr Val Leu Gly Glu Tyr Gly Pro Arg Ile Val Glu 
        435                 440                 445             

Leu Asp Gly Tyr Pro Ile Asp Thr Pro Ile Gln Gly Ile Leu Ile Tyr 
    450                 455                 460                 

Thr Arg His Glu Asp Arg Pro Gly Met Ile Gly Arg Ile Gly Thr Leu 
465                 470                 475                 480 

Leu Gly Asp Arg Asp Ile Asn Ile Ala Gly Met Gln Val Gly Arg Arg 
                485                 490                 495     

Glu Thr Gly Gly Glu Ala Val Met Leu Leu Ser Val Asp Lys Arg Val 
            500                 505                 510         

Pro Gln Asp Val Ile Asp Glu Ile Ala Lys His Pro Gly Ile Arg Leu 
        515                 520                 525             

Val Arg Ala Ile Glu Leu 
    530                 

<210>   1386
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1378

<400>   1386
Met Val Arg Glu Asn Met Ala Thr Lys Ile Leu Val Thr Asp Asp Ile 
                5                   10                  15      

Ser Gln Ala Gly Ile Asp Ile Leu Ser Gly Leu Gln Gly Ala Glu Val 
            20                  25                  30          

Val Val Arg Thr Asn Leu Ala Pro Asp Glu Leu Lys Glu Ala Ile Ala 
        35                  40                  45              

Asp Ala Asp Ala Leu Val Val Arg Ser Gln Thr Arg Val Thr Arg Asp 
    50                  55                  60                  

Val Ile Glu Ser Ala Lys Lys Leu Lys Val Ile Gly Arg Ala Gly Val 
65                  70                  75                  80  

Gly Val Asp Asn Ile Asp Leu Glu Ala Ala Thr Arg Arg Gly Ile Leu 
                85                  90                  95      

Val Ile Asn Ala Pro Asp Gly Asn Thr Ile Ala Ala Ala Glu His Thr 
            100                 105                 110         

Phe Ala Met Met Ile Ser Leu Ala Arg His Ile Pro Ala Ala His Arg 
        115                 120                 125             

Asp Leu Leu Gln Gly Asn Trp Asn Arg Lys Lys Trp Ile Gly Val Glu 
    130                 135                 140                 

Leu Arg Gly Lys Thr Leu Ala Val Leu Gly Met Gly Arg Ile Gly Thr 
145                 150                 155                 160 

Glu Val Ala Lys Arg Ala Lys Ala Phe Gly Met Thr Val Leu Gly Tyr 
                165                 170                 175     

Asp Pro Phe Leu Thr Glu Glu Arg Ala Gln Ser Leu Gly Val Lys Arg 
            180                 185                 190         

Cys Asp Leu Asp Thr Ala Ile Arg Glu Ala Asp Phe Ile Thr Val His 
        195                 200                 205             

Thr Pro Leu Thr Lys Glu Thr His His Met Ile Asp Ala Gly Arg Ile 
    210                 215                 220                 

Ala Gln Met Lys Glu Gly Val Arg Ile Ile Asn Cys Ala Arg Gly Gly 
225                 230                 235                 240 

Ile Ile Asp Glu Val Ala Leu Ala Glu Ala Leu Glu Ala Gly Arg Val 
                245                 250                 255     

Ala Gly Ala Ala Ile Asp Val Phe Glu Gln Glu Pro Leu Pro Met Asp 
            260                 265                 270         

His Pro Leu Arg Arg Cys Pro Asn Val Val Leu Thr Pro His Leu Gly 
        275                 280                 285             

Ala Ser Thr Val Glu Ala Gln Glu Asn Val Ala Ile Gln Val Ala Glu 
    290                 295                 300                 

Glu Ile Val Gln Val Leu Arg Asp Asp Thr Phe Glu His Ala Val Asn 
305                 310                 315                 320 

Leu Pro Ser Leu Ser Gln Arg Gln Lys Asp Arg Leu Ala Pro Tyr Leu 
                325                 330                 335     

Ala Leu Ala Glu Gln Leu Gly Leu Phe Ala Ala Gln Leu Ala Gln Gly 
            340                 345                 350         

Ala Pro Ser Ser Met Thr Val Arg Tyr Ala Gly Asp Ala Ala Asp Pro 
        355                 360                 365             

Asp Gly Gly Tyr Leu Thr Arg Thr Val Leu Lys Gly Phe Phe Ser Phe 
    370                 375                 380                 

Gln Tyr Asn Gly Glu Val Asn Tyr Val Asn Ala Leu Arg Tyr Ala Glu 
385                 390                 395                 400 

Asp Ala Gly Leu Arg Val Gln Glu Val Arg Glu Ser Arg Gly Arg Val 
                405                 410                 415     

Tyr Thr Asn Glu Val Glu Ile Ser Val Ala Thr Asp Asn Gly Thr His 
            420                 425                 430         

Arg Val Thr Gly Thr Val Leu Gly Glu Tyr Gly Pro Arg Ile Val Glu 
        435                 440                 445             

Leu Asp Gly Tyr Pro Ile Asp Thr Pro Ile Gln Gly Ile Leu Ile Tyr 
    450                 455                 460                 

Thr Arg His Glu Asp Arg Pro Gly Met Ile Gly Arg Ile Gly Thr Leu 
465                 470                 475                 480 

Leu Gly Asp Arg Asp Ile Asn Ile Ala Gly Met Gln Val Gly Arg Arg 
                485                 490                 495     

Glu Thr Gly Gly Glu Ala Val Met Leu Leu Ser Val Asp Lys Arg Val 
            500                 505                 510         

Pro Gln Asp Val Ile Asp Glu Ile Ala Lys His Pro Gly Ile Arg Leu 
        515                 520                 525             

Val Arg Ala Ile Glu Leu 
    530                 

<210>   1387
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1378

<400>   1387
Met Val Arg Glu Asn Met Ala Thr Lys Ile Leu Val Thr Asp Asp Ile 
                5                   10                  15      

Ser Gln Ala Gly Ile Asp Ile Leu Ser Gly Leu Gln Gly Ala Glu Val 
            20                  25                  30          

Val Val Arg Thr Asn Leu Ala Pro Asp Glu Leu Lys Glu Ala Ile Ala 
        35                  40                  45              

Asp Ala Asp Ala Leu Val Val Arg Ser Gln Thr Arg Val Thr Arg Asp 
    50                  55                  60                  

Val Ile Glu Ser Ala Lys Lys Leu Lys Val Ile Gly Arg Ala Gly Val 
65                  70                  75                  80  

Gly Val Asp Asn Ile Asp Leu Glu Ala Ala Thr Arg Arg Gly Ile Leu 
                85                  90                  95      

Val Ile Asn Ala Pro Asp Gly Asn Thr Ile Ala Ala Ala Glu His Thr 
            100                 105                 110         

Phe Ala Met Met Ile Ser Leu Ala Arg His Ile Pro Ala Ala His Arg 
        115                 120                 125             

Asp Leu Leu Gln Gly Asn Trp Asn Arg Lys Lys Trp Ile Gly Val Glu 
    130                 135                 140                 

Leu Arg Gly Lys Thr Leu Ala Val Leu Gly Met Gly Arg Ile Gly Thr 
145                 150                 155                 160 

Glu Val Ala Lys Arg Ala Lys Ala Phe Gly Met Thr Val Leu Gly Tyr 
                165                 170                 175     

Asp Pro Phe Leu Thr Glu Glu Arg Ala Gln Ser Leu Gly Val Lys Arg 
            180                 185                 190         

Cys Asp Leu Asp Thr Ala Ile Arg Glu Ala Asp Phe Ile Thr Val His 
        195                 200                 205             

Thr Pro Leu Thr Lys Glu Thr His His Met Ile Asp Ala Gly Arg Ile 
    210                 215                 220                 

Ala Gln Met Lys Glu Gly Val Arg Ile Ile Asn Cys Ala Arg Gly Gly 
225                 230                 235                 240 

Ile Ile Asp Glu Val Ala Leu Ala Glu Ala Leu Glu Ala Gly Arg Val 
                245                 250                 255     

Ala Gly Ala Ala Ile Asp Val Phe Glu Gln Glu Pro Leu Pro Met Asp 
            260                 265                 270         

His Pro Leu Arg Arg Cys Pro Asn Val Val Leu Thr Pro His Leu Gly 
        275                 280                 285             

Ala Ser Thr Val Glu Ala Gln Glu Asn Val Ala Ile Gln Val Ala Glu 
    290                 295                 300                 

Glu Ile Val Gln Val Leu Arg Asp Asp Thr Phe Glu His Ala Val Asn 
305                 310                 315                 320 

Leu Pro Ser Leu Ser Gln Arg Gln Lys Glu Arg Leu Ala Pro Tyr Leu 
                325                 330                 335     

Ala Leu Ala Glu Gln Leu Gly Leu Phe Ala Ala Gln Leu Ala Gln Gly 
            340                 345                 350         

Ala Pro Ser Ser Met Thr Val Arg Tyr Ala Gly Asp Ala Ala Asp Pro 
        355                 360                 365             

Asp Gly Gly Tyr Leu Thr Arg Thr Val Leu Lys Gly Phe Phe Ser Phe 
    370                 375                 380                 

Gln Tyr Asn Gly Glu Val Asn Tyr Val Asn Ala Leu Arg Tyr Ala Glu 
385                 390                 395                 400 

Asp Ala Gly Leu Lys Val Gln Glu Val Arg Glu Ser Arg Gly Arg Val 
                405                 410                 415     

Tyr Thr Asn Glu Val Glu Ile Ser Val Ala Thr Asp Asn Gly Thr His 
            420                 425                 430         

Arg Val Thr Gly Thr Val Leu Gly Glu Tyr Gly Pro Arg Ile Val Glu 
        435                 440                 445             

Leu Asp Gly Tyr Pro Ile Asp Thr Pro Ile Gln Gly Ile Leu Ile Tyr 
    450                 455                 460                 

Thr Arg His Glu Asp Arg Pro Gly Met Ile Gly Arg Ile Gly Thr Leu 
465                 470                 475                 480 

Leu Gly Asp Arg Asp Ile Asn Ile Ala Gly Met Gln Val Gly Arg Arg 
                485                 490                 495     

Glu Thr Gly Gly Glu Ala Val Met Leu Leu Ser Val Asp Lys Arg Val 
            500                 505                 510         

Pro Gln Asp Val Ile Asp Glu Ile Ala Lys His Pro Gly Ile Arg Leu 
        515                 520                 525             

Val Arg Ala Ile Glu Leu 
    530                 

<210>   1388
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1378

<400>   1388
Met Val Arg Glu Asn Met Ala Thr Lys Ile Leu Val Thr Asp Asp Ile 
                5                   10                  15      

Ser Gln Ala Gly Ile Asp Ile Leu Ser Gly Leu Gln Gly Ala Glu Val 
            20                  25                  30          

Val Val Arg Thr Asn Leu Ala Pro Asp Glu Leu Lys Glu Ala Ile Ala 
        35                  40                  45              

Asp Ala Asp Ala Leu Val Val Arg Ser Gln Thr Arg Val Thr Arg Asp 
    50                  55                  60                  

Val Ile Glu Ser Ala Lys Lys Leu Lys Val Ile Gly Arg Ala Gly Val 
65                  70                  75                  80  

Gly Val Asp Asn Ile Asp Leu Glu Ala Ala Thr Arg Arg Gly Ile Leu 
                85                  90                  95      

Val Ile Asn Ala Pro Asp Gly Asn Thr Ile Ala Ala Ala Glu His Thr 
            100                 105                 110         

Phe Ala Met Met Ile Ser Leu Ala Arg His Ile Pro Ala Ala His Arg 
        115                 120                 125             

Asp Leu Leu Gln Gly Asn Trp Asn Arg Lys Lys Trp Ile Gly Val Glu 
    130                 135                 140                 

Leu Arg Gly Lys Thr Leu Ala Val Leu Gly Met Gly Arg Ile Gly Thr 
145                 150                 155                 160 

Glu Val Ala Lys Arg Ala Lys Ala Phe Gly Met Thr Val Leu Gly Tyr 
                165                 170                 175     

Asp Pro Phe Leu Thr Glu Glu Arg Ala Gln Ser Leu Gly Val Lys Arg 
            180                 185                 190         

Cys Asp Leu Asp Thr Ala Ile Arg Glu Ala Asp Phe Ile Thr Val His 
        195                 200                 205             

Thr Pro Leu Thr Lys Glu Thr His His Met Ile Asp Ala Gly Arg Ile 
    210                 215                 220                 

Ala Gln Met Lys Glu Gly Val Arg Ile Ile Asn Cys Ala Arg Gly Gly 
225                 230                 235                 240 

Ile Ile Asp Glu Val Ala Leu Ala Glu Ala Leu Glu Ala Gly Arg Val 
                245                 250                 255     

Ala Gly Ala Ala Ile Asp Val Phe Glu Asn Glu Pro Leu Pro Met Asp 
            260                 265                 270         

His Pro Leu Arg Arg Cys Pro Asn Val Val Leu Thr Pro His Leu Gly 
        275                 280                 285             

Ala Ser Thr Val Glu Ala Gln Glu Asn Val Ala Ile Gln Val Ala Glu 
    290                 295                 300                 

Glu Ile Val Gln Val Leu Arg Asp Asp Thr Phe Glu His Ala Val Asn 
305                 310                 315                 320 

Leu Pro Ser Leu Ser Gln Arg Gln Lys Glu Arg Leu Ala Pro Tyr Leu 
                325                 330                 335     

Ala Leu Ala Glu Gln Leu Gly Leu Phe Ala Ala Gln Leu Ala Gln Gly 
            340                 345                 350         

Ala Pro Ser Ser Met Thr Val Arg Tyr Ala Gly Asp Ala Ala Asp Pro 
        355                 360                 365             

Asp Gly Gly Tyr Leu Thr Arg Thr Val Leu Lys Gly Phe Phe Ser Phe 
    370                 375                 380                 

Gln Tyr Asn Gly Glu Val Asn Tyr Val Asn Ala Leu Arg Tyr Ala Glu 
385                 390                 395                 400 

Asp Ala Gly Leu Arg Val Gln Glu Val Arg Glu Ser Arg Gly Arg Val 
                405                 410                 415     

Tyr Thr Asn Glu Val Glu Ile Ser Val Ala Thr Asp Asn Gly Thr His 
            420                 425                 430         

Arg Val Thr Gly Thr Val Leu Gly Glu Tyr Gly Pro Arg Ile Val Glu 
        435                 440                 445             

Leu Asp Gly Tyr Pro Ile Asp Thr Pro Ile Gln Gly Ile Leu Ile Tyr 
    450                 455                 460                 

Thr Arg His Glu Asp Arg Pro Gly Met Ile Gly Arg Ile Gly Thr Leu 
465                 470                 475                 480 

Leu Gly Asp Arg Asp Ile Asn Ile Ala Gly Met Gln Val Gly Arg Arg 
                485                 490                 495     

Glu Thr Gly Gly Glu Ala Val Met Leu Leu Ser Val Asp Lys Arg Val 
            500                 505                 510         

Pro Gln Asp Val Ile Asp Glu Ile Ala Lys His Pro Gly Ile Arg Leu 
        515                 520                 525             

Val Arg Ala Ile Glu Leu 
    530                 

<210>   1389
<211>   534
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1378

<400>   1389
Met Val Arg Glu Asn Met Ala Thr Lys Ile Leu Val Thr Asp Asp Ile 
                5                   10                  15      

Ser Gln Ala Gly Ile Asp Ile Leu Ser Gly Leu Gln Gly Ala Glu Val 
            20                  25                  30          

Val Val Arg Thr Asn Leu Ala Pro Asp Glu Leu Lys Glu Ala Ile Ala 
        35                  40                  45              

Asp Ala Asp Ala Leu Val Val Arg Ser Gln Thr Arg Val Thr Arg Asp 
    50                  55                  60                  

Val Ile Glu Ser Ala Lys Lys Leu Lys Val Ile Gly Arg Ala Gly Val 
65                  70                  75                  80  

Gly Val Asp Asn Ile Asp Leu Glu Ala Ala Thr Arg Arg Gly Ile Leu 
                85                  90                  95      

Val Ile Asn Ala Pro Asp Gly Asn Thr Ile Ala Ala Ala Glu His Thr 
            100                 105                 110         

Phe Ala Met Met Ile Ser Leu Ala Arg His Ile Pro Ala Ala His Arg 
        115                 120                 125             

Asp Leu Leu Gln Gly Asn Trp Asn Arg Lys Lys Trp Ile Gly Val Glu 
    130                 135                 140                 

Leu Arg Gly Lys Thr Leu Ala Val Leu Gly Met Gly Arg Ile Gly Thr 
145                 150                 155                 160 

Glu Val Ala Lys Arg Ala Lys Ala Phe Gly Met Thr Val Leu Gly Tyr 
                165                 170                 175     

Asp Pro Phe Leu Thr Glu Glu Arg Ala Gln Ser Leu Gly Val Lys Arg 
            180                 185                 190         

Cys Asp Leu Asp Thr Ala Ile Arg Glu Ala Asp Phe Ile Thr Val His 
        195                 200                 205             

Thr Pro Leu Thr Lys Glu Thr His His Met Ile Asp Ala Gly Arg Ile 
    210                 215                 220                 

Ala Gln Met Lys Glu Gly Val Arg Ile Ile Asn Cys Ala Arg Gly Gly 
225                 230                 235                 240 

Ile Ile Asp Glu Val Ala Leu Ala Glu Ala Leu Glu Ala Gly Arg Val 
                245                 250                 255     

Ala Gly Ala Ala Ile Asp Val Phe Glu Gln Glu Pro Leu Pro Met Asp 
            260                 265                 270         

His Pro Leu Arg Arg Cys Pro Asn Val Val Leu Thr Pro His Leu Gly 
        275                 280                 285             

Ala Ser Thr Val Glu Ala Gln Glu Asn Val Ala Ile Gln Val Ala Glu 
    290                 295                 300                 

Glu Ile Val Gln Val Leu Arg Asp Asp Thr Phe Glu His Ala Val Asn 
305                 310                 315                 320 

Leu Pro Ser Leu Ser Gln Arg Gln Lys Glu Arg Leu Ala Pro Tyr Leu 
                325                 330                 335     

Ala Leu Ala Glu Gln Leu Gly Leu Phe Ala Ala Gln Leu Ala Gln Gly 
            340                 345                 350         

Ala Pro Ser Ser Met Thr Val Arg Tyr Ala Gly Asp Ala Ala Asp Pro 
        355                 360                 365             

Asp Gly Gly Tyr Leu Thr Arg Thr Val Leu Lys Gly Phe Phe Ser Phe 
    370                 375                 380                 

Gln Tyr Asn Gly Glu Val Asn Tyr Val Asn Ala Leu Arg Tyr Ala Glu 
385                 390                 395                 400 

Asp Ala Gly Leu Arg Val Gln Glu Val Arg Glu Ser Arg Gly Arg Val 
                405                 410                 415     

Tyr Thr Asn Glu Val Glu Ile Ser Val Ala Thr Asp Asn Gly Thr His 
            420                 425                 430         

Arg Val Thr Gly Thr Val Leu Gly Glu Tyr Gly Pro Arg Ile Val Glu 
        435                 440                 445             

Leu Asp Gly Tyr Pro Ile Asp Thr Pro Ile Gln Gly Ile Leu Ile Tyr 
    450                 455                 460                 

Thr Arg His Glu Asp Arg Pro Gly Met Ile Gly Arg Ile Gly Thr Leu 
465                 470                 475                 480 

Leu Gly Asp Arg Asp Leu Asn Ile Ala Gly Met Gln Val Gly Arg Arg 
                485                 490                 495     

Glu Thr Gly Gly Glu Ala Val Met Leu Leu Ser Val Asp Lys Arg Val 
            500                 505                 510         

Pro Gln Asp Val Ile Asp Glu Ile Ala Lys His Pro Gly Ile Arg Leu 
        515                 520                 525             

Val Arg Ala Ile Glu Leu 
    530                 

<210>   1390
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1379

<400>   1390
gtggtgagag agaacatggc gaccaagatt ttggtgacgg acgacatctc ccaggcgggc       60

atcgacatcc tctccggcct tcagggcgcg gaggtcgtgg tcaggacgaa tctcgcgccg      120

gacgagctga aggaggccat tgccgacgcg gacgcccttg tggtgcgctc gcagacgcgc      180

gtgacgaggg acgtgatcga gagcgcgaaa aagctcaagg tcatcggccg cgcgggcgtc      240

ggcgtcgaca acatcgatct tgaggcggcc acgcgccgcg gcatcctggt catcaacgcc      300

ccagatggca acaccattgc ggcggcggag cacaccttcg cgatgatgat cagccttgcg      360

cggcacatcc ccgcggctca tcgggatctc ctccagggca actggaatcg caagaagtgg      420

attggcgtcg agcttcgcgg caagacgctg gcggtcctcg gcatgggccg catcggcacg      480

gaggtcgcga agcgggcgaa ggcgttcggc atgactgtcc tcgggtatga tccgttcctg      540

acggaggagc gcgcgcagag cctcggcgtc aagcggtgcg atctcgacac cgccatccgc      600

gaggccgact tcatcaccgt gcacacgccg ctgacgaaag agacgcatca catgattgat      660

gccggccgga tcgcccagat gaaggagggc gtgcggatca tcaactgcgc gcgcggcggc      720

atcatcgacg aggtggcgct cgcggaggcg ctcgaggcgg ggcgcgtggc gggcgccgcc      780

atcgacgtgt ttgagcagga gccgctgccg atggatcacc cgctcaggcg ctgcccgaac      840

gtcgtgttga cgccgcacct cggcgcgtcg acggtggagg cgcaggagaa cgtggcgatt      900

caagtggcgg aggaaatcgt gcaggtgctt cgcgacgaca ccttcgagca cgcggtcaac      960

ctgccgagcc tgagccagcg ccagaaggag cggctcgcgc cttatctcgc ccttgcggag     1020

caactggggc tgtttgcggc gcagctcgcg cagggcgcgc cctcgagcat gaccgtgcgc     1080

tacgccggtg acgcggccga tccagacggc ggctacctca cccgcacggt gctgaagggc     1140

ttcttcagct tccagtacaa cggcgaggtc aactacgtca acgcgctgcg gtacgcggaa     1200

gacgcgggcc tgcgtgtgca ggaggtgcgc gagtcgcgcg gccgggtgta cacgaacgat     1260

gtggagatct cggtcgcgac ggacaacggc acgcaccgcg tgacgggcac ggtcctcggg     1320

gagtacgggc cgcgcatcgt cgagctcgac gggtacccca ttgacacgcc cattcaaggc     1380

atcctcatct acacgcggca cgaggaccgt cccggcatga tcggccgcat cggcacgcta     1440

cttggcgatc gcgacatcaa cattgccggc atgcaggtgg gccggcggga gacgggcgga     1500

gaagcggtga tgctcctgtc cgtcgacaag cgcgtgccgc aggacgtgat cgacgaaatc     1560

gcgaagcatc cgggcattcg actggtcagg gccatcgagc tgtga                     1605


<210>   1391
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1379

<400>   1391
gtggtgagag agaacatggc gaccaagatt ttggtgacgg acgacatctc ccaggcgggc       60

atcgacatcc tctccggcct tcagggcgcg gaggtcgtgg tcaggacgaa tctcgcgccg      120

gacgagctga aggaggccat tgccgacgcg gacgcccttg tggtgcgctc gcagacgcgc      180

gtgacgaggg acgtgatcga gagcgcgaaa aagctcaagg tcatcggccg cgcgggcgtc      240

ggcgtcgaca acatcgatct tgaggcggcc acgcgccgcg gcatcctggt catcaacgcc      300

ccagatggca acaccattgc ggcggcggag cacaccttcg cgatgatgat cagccttgcg      360

cggcacatcc ccgcggctca tcgggatctc ctccagggca actggaatcg caagaagtgg      420

attggcgtcg agcttcgcgg caagacgctg gcggtcctcg gcatgggccg catcggcacg      480

gaggtcgcga agcgggcgaa ggcgttcggc atgactgtcc tcgggtatga tccgttcctg      540

acggaggagc gcgcgcagag cctcggcgtc aagcggtgcg atctcgacac cgccatccgc      600

gaggccgact tcatcaccgt gcacacgccg ctgacgaaag agacgcatca catgattgat      660

gccggccgga tcgcccagat gaaggagggc gtgcggatca tcaactgcgc gcgcggcggc      720

atcatcgacg aggtggcgct cgcggaggcg ctcgaggcgg ggcgcgtggc gggcgccgcc      780

atcgacgtgt ttgagcagga gccgctgccg atggatcacc cgctcaggcg ctgcccgaac      840

gtcgtgttga cgccgcacct cggcgcgtcg acggtggagg cgcaggagaa cgtggcgatt      900

caagtggcgg aggaaatcgt gcaggtgctt cgcgacgaca ccttcgagca cgcggtcaac      960

ctgccgagcc tgagccagcg ccagaaggat cggctcgcgc cttatctcgc ccttgcggag     1020

caactggggc tgtttgcggc gcagctcgcg cagggcgcgc cctcgagcat gaccgtgcgc     1080

tacgccggtg acgcggccga tccagacggc ggctacctca cccgcacggt gctgaagggc     1140

ttcttcagct tccagtacaa cggcgaggtc aactacgtca acgcgctgcg gtacgcggaa     1200

gacgcgggcc tgcgtgtgca ggaggtgcgc gagtcgcgcg gccgggtgta cacgaacgag     1260

gtggagatct cggtcgcgac ggacaacggc acgcaccgcg tgacgggcac ggtcctcggg     1320

gagtacgggc cgcgcatcgt cgagctcgac gggtacccca ttgacacgcc cattcaaggc     1380

atcctcatct acacgcggca cgaggaccgt cccggcatga tcggccgcat cggcacgcta     1440

cttggcgatc gcgacatcaa cattgccggc atgcaggtgg gccggcggga gacgggcgga     1500

gaagcggtga tgctcctgtc cgtcgacaag cgcgtgccgc aggacgtgat cgacgaaatc     1560

gcgaagcatc cgggcattcg actggtcagg gccatcgagc tgtga                     1605


<210>   1392
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1379

<400>   1392
gtggtgagag agaacatggc gaccaagatt ttggtgacgg acgacatctc ccaggcgggc       60

atcgacatcc tctccggcct tcagggcgcg gaggtcgtgg tcaggacgaa tctcgcgccg      120

gacgagctga aggaggccat tgccgacgcg gacgcccttg tggtgcgctc gcagacgcgc      180

gtgacgaggg acgtgatcga gagcgcgaaa aagctcaagg tcatcggccg cgcgggcgtc      240

ggcgtcgaca acatcgatct tgaggcggcc acgcgccgcg gcatcctggt catcaacgcc      300

ccagatggca acaccattgc ggcggcggag cacaccttcg cgatgatgat cagccttgcg      360

cggcacatcc ccgcggctca tcgggatctc ctccagggca actggaatcg caagaagtgg      420

attggcgtcg agcttcgcgg caagacgctg gcggtcctcg gcatgggccg catcggcacg      480

gaggtcgcga agcgggcgaa ggcgttcggc atgactgtcc tcgggtatga tccgttcctg      540

acggaggagc gcgcgcagag cctcggcgtc aagcggtgcg atctcgacac cgccatccgc      600

gaggccgact tcatcaccgt gcacacgccg ctgacgaaag agacgcatca catgattgat      660

gccggccgga tcgcccagat gaaggagggc gtgcggatca tcaactgcgc gcgcggcggc      720

atcatcgacg aggtggcgct cgcggaggcg ctcgaggcgg ggcgcgtggc gggcgccgcc      780

atcgacgtgt ttgagcagga gccgctgccg atggatcacc cgctcaggcg ctgcccgaac      840

gtcgtgttga cgccgcacct cggcgcgtcg acggtggagg cgcaggagaa cgtggcgatt      900

caagtggcgg aggaaatcgt gcaggtgctt cgcgacgaca ccttcgagca cgcggtcaac      960

ctgccgagcc tgagccagcg ccagaaggag cggctcgcgc cttatctcgc ccttgcggag     1020

caactggggc tgtttgcggc gcagctcgcg cagggcgcgc cctcgagcat gaccgtgcgc     1080

tacgccggtg acgcggccga tccagacggc ggctacctca cccgcacggt gctgaagggc     1140

ttcttcagct tccagtacaa cggcgaggtc aactacgtca acgcgctgcg gtacgcggaa     1200

gacgcgggcc tgaaagtgca ggaggtgcgc gagtcgcgcg gccgggtgta cacgaacgag     1260

gtggagatct cggtcgcgac ggacaacggc acgcaccgcg tgacgggcac ggtcctcggg     1320

gagtacgggc cgcgcatcgt cgagctcgac gggtacccca ttgacacgcc cattcaaggc     1380

atcctcatct acacgcggca cgaggaccgt cccggcatga tcggccgcat cggcacgcta     1440

cttggcgatc gcgacatcaa cattgccggc atgcaggtgg gccggcggga gacgggcgga     1500

gaagcggtga tgctcctgtc cgtcgacaag cgcgtgccgc aggacgtgat cgacgaaatc     1560

gcgaagcatc cgggcattcg actggtcagg gccatcgagc tgtga                     1605


<210>   1393
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1379

<400>   1393
gtggtgagag agaacatggc gaccaagatt ttggtgacgg acgacatctc ccaggcgggc       60

atcgacatcc tctccggcct tcagggcgcg gaggtcgtgg tcaggacgaa tctcgcgccg      120

gacgagctga aggaggccat tgccgacgcg gacgcccttg tggtgcgctc gcagacgcgc      180

gtgacgaggg acgtgatcga gagcgcgaaa aagctcaagg tcatcggccg cgcgggcgtc      240

ggcgtcgaca acatcgatct tgaggcggcc acgcgccgcg gcatcctggt catcaacgcc      300

ccagatggca acaccattgc ggcggcggag cacaccttcg cgatgatgat cagccttgcg      360

cggcacatcc ccgcggctca tcgggatctc ctccagggca actggaatcg caagaagtgg      420

attggcgtcg agcttcgcgg caagacgctg gcggtcctcg gcatgggccg catcggcacg      480

gaggtcgcga agcgggcgaa ggcgttcggc atgactgtcc tcgggtatga tccgttcctg      540

acggaggagc gcgcgcagag cctcggcgtc aagcggtgcg atctcgacac cgccatccgc      600

gaggccgact tcatcaccgt gcacacgccg ctgacgaaag agacgcatca catgattgat      660

gccggccgga tcgcccagat gaaggagggc gtgcggatca tcaactgcgc gcgcggcggc      720

atcatcgacg aggtggcgct cgcggaggcg ctcgaggcgg ggcgcgtggc gggcgccgcc      780

atcgacgtgt ttgagaatga gccgctgccg atggatcacc cgctcaggcg ctgcccgaac      840

gtcgtgttga cgccgcacct cggcgcgtcg acggtggagg cgcaggagaa cgtggcgatt      900

caagtggcgg aggaaatcgt gcaggtgctt cgcgacgaca ccttcgagca cgcggtcaac      960

ctgccgagcc tgagccagcg ccagaaggag cggctcgcgc cttatctcgc ccttgcggag     1020

caactggggc tgtttgcggc gcagctcgcg cagggcgcgc cctcgagcat gaccgtgcgc     1080

tacgccggtg acgcggccga tccagacggc ggctacctca cccgcacggt gctgaagggc     1140

ttcttcagct tccagtacaa cggcgaggtc aactacgtca acgcgctgcg gtacgcggaa     1200

gacgcgggcc tgcgtgtgca ggaggtgcgc gagtcgcgcg gccgggtgta cacgaacgag     1260

gtggagatct cggtcgcgac ggacaacggc acgcaccgcg tgacgggcac ggtcctcggg     1320

gagtacgggc cgcgcatcgt cgagctcgac gggtacccca ttgacacgcc cattcaaggc     1380

atcctcatct acacgcggca cgaggaccgt cccggcatga tcggccgcat cggcacgcta     1440

cttggcgatc gcgacatcaa cattgccggc atgcaggtgg gccggcggga gacgggcgga     1500

gaagcggtga tgctcctgtc cgtcgacaag cgcgtgccgc aggacgtgat cgacgaaatc     1560

gcgaagcatc cgggcattcg actggtcagg gccatcgagc tgtga                     1605


<210>   1394
<211>   1605
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1379

<400>   1394
gtggtgagag agaacatggc gaccaagatt ttggtgacgg acgacatctc ccaggcgggc       60

atcgacatcc tctccggcct tcagggcgcg gaggtcgtgg tcaggacgaa tctcgcgccg      120

gacgagctga aggaggccat tgccgacgcg gacgcccttg tggtgcgctc gcagacgcgc      180

gtgacgaggg acgtgatcga gagcgcgaaa aagctcaagg tcatcggccg cgcgggcgtc      240

ggcgtcgaca acatcgatct tgaggcggcc acgcgccgcg gcatcctggt catcaacgcc      300

ccagatggca acaccattgc ggcggcggag cacaccttcg cgatgatgat cagccttgcg      360

cggcacatcc ccgcggctca tcgggatctc ctccagggca actggaatcg caagaagtgg      420

attggcgtcg agcttcgcgg caagacgctg gcggtcctcg gcatgggccg catcggcacg      480

gaggtcgcga agcgggcgaa ggcgttcggc atgactgtcc tcgggtatga tccgttcctg      540

acggaggagc gcgcgcagag cctcggcgtc aagcggtgcg atctcgacac cgccatccgc      600

gaggccgact tcatcaccgt gcacacgccg ctgacgaaag agacgcatca catgattgat      660

gccggccgga tcgcccagat gaaggagggc gtgcggatca tcaactgcgc gcgcggcggc      720

atcatcgacg aggtggcgct cgcggaggcg ctcgaggcgg ggcgcgtggc gggcgccgcc      780

atcgacgtgt ttgagcagga gccgctgccg atggatcacc cgctcaggcg ctgcccgaac      840

gtcgtgttga cgccgcacct cggcgcgtcg acggtggagg cgcaggagaa cgtggcgatt      900

caagtggcgg aggaaatcgt gcaggtgctt cgcgacgaca ccttcgagca cgcggtcaac      960

ctgccgagcc tgagccagcg ccagaaggag cggctcgcgc cttatctcgc ccttgcggag     1020

caactggggc tgtttgcggc gcagctcgcg cagggcgcgc cctcgagcat gaccgtgcgc     1080

tacgccggtg acgcggccga tccagacggc ggctacctca cccgcacggt gctgaagggc     1140

ttcttcagct tccagtacaa cggcgaggtc aactacgtca acgcgctgcg gtacgcggaa     1200

gacgcgggcc tgcgtgtgca ggaggtgcgc gagtcgcgcg gccgggtgta cacgaacgag     1260

gtggagatct cggtcgcgac ggacaacggc acgcaccgcg tgacgggcac ggtcctcggg     1320

gagtacgggc cgcgcatcgt cgagctcgac gggtacccca ttgacacgcc cattcaaggc     1380

atcctcatct acacgcggca cgaggaccgt cccggcatga tcggccgcat cggcacgcta     1440

cttggcgatc gcgacttaaa cattgccggc atgcaggtgg gccggcggga gacgggcgga     1500

gaagcggtga tgctcctgtc cgtcgacaag cgcgtgccgc aggacgtgat cgacgaaatc     1560

gcgaagcatc cgggcattcg actggtcagg gccatcgagc tgtga                     1605


<210>   1395
<211>   312
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1395
Met Thr Ile Arg Leu Thr Arg Ile Val Ile Ile Gly Val Gly Ser Val 
                5                   10                  15      

Gly Thr Ala Thr Ala Tyr Thr Leu Tyr Leu Arg Glu Arg Ala Ser Glu 
            20                  25                  30          

Val Val Leu Ile Asp Ala Asp Met Gln Lys Ala Glu Gly Glu Ala Leu 
        35                  40                  45              

Asp Met Gln His Gly Ser Ile Tyr Cys Gly Gly Thr Lys Ile Arg Ala 
    50                  55                  60                  

Gly Thr Tyr Glu Asp Cys Ala Thr Ala Asp Ile Val Ile Val Thr Ala 
65                  70                  75                  80  

Gly Val Ala Gln Arg Pro Gly Gln Ser Arg Ile Asp Leu Leu Val Lys 
                85                  90                  95      

Asn Ile Gln Val Ile Gln Asp Ile Ser Phe Lys Leu Lys Gln Tyr Gly 
            100                 105                 110         

Phe Asn Gly Ile Leu Ile Val Ala Ser Asn Pro Val Asp Ile Leu Ser 
        115                 120                 125             

Tyr Val Ala Trp Tyr Ile Ser Gly Leu Pro Ser Glu Arg Val Ile Gly 
    130                 135                 140                 

Ser Gly Thr Val Leu Asp Ser Leu Arg Phe Arg Tyr Tyr Leu Gly Arg 
145                 150                 155                 160 

Glu Leu Gly Val Asp Pro Gly Ser Val His Ala Gln Val Leu Gly Glu 
                165                 170                 175     

His Gly Asp Thr Gln Val His Ile Trp Ser Ser Leu Asn Val Gly Gly 
            180                 185                 190         

Val Gln Val Pro Ile Ser Glu Arg Ile Arg Gly Val Glu Asp His Thr 
        195                 200                 205             

Arg Arg Ala Ala Tyr Glu Leu Ile Glu His Lys Gly Tyr Thr Asn Tyr 
    210                 215                 220                 

Gly Ile Ala Leu Val Leu Asp Ala Ile Cys Glu Ala Ile Leu Gln Asp 
225                 230                 235                 240 

Lys His Thr Val Leu Thr Val Ser Thr Lys Val Ala Glu Tyr His Gly 
                245                 250                 255     

Val Ser Asp Val Tyr Leu Ser Val Pro Cys Val Ile Gly Val Arg Gly 
            260                 265                 270         

Ile Glu Arg Val Ile Glu Val Pro Met Ser Asp Met Glu Glu Arg Val 
        275                 280                 285             

Phe Gln Glu Ser Ala Lys His Leu Tyr Asn Ala Thr Arg Glu Ala Ile 
    290                 295                 300                 

Arg Ile Ile Gly Trp Arg Glu Ser 
305                 310         

<210>   1396
<211>   939
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1396
atgacaatac gattgactcg gattgtgata attggagtgg gttctgtagg aacagccact       60

gcttacacac tatatttacg ggaacgagca tcagaagtcg tcttaattga tgcggatatg      120

caaaaagcgg aaggcgaagc tctagatatg caacacggta gtatttattg cggtgggacg      180

aaaatccgcg cgggtacata tgaggactgt gcaacagcag acatcgtaat tgtcacggct      240

ggagtggctc agaggcctgg acaatcacgt attgacctct tggtgaagaa tatacaagtt      300

attcaggata tttcttttaa actaaaacaa tatggtttta atggaattct cattgttgca      360

tccaatcccg tagatatact tagctatgtc gcatggtata tttcgggctt gccatctgaa      420

cgggtaatag gatcagggac tgtcttggat tcgctcaggt tccgatatta ccttggtaga      480

gaattggggg tcgatcctgg gagtgtccat gcacaggtgc taggcgaaca tggtgacacg      540

caagttcaca tatggagtag tttgaatgtt ggtggagttc aggtgccaat atctgaaagg      600

attaggggcg tcgaggacca tacgcgtcga gctgcttatg aattaattga acacaaaggt      660

tacacaaatt atggaatcgc attagtgctc gatgcaatct gcgaagctat attacaggac      720

aaacatacgg ttttgactgt ttcaacaaaa gtagcagaat atcacggggt atcggatgtt      780

tatttgagtg ttccgtgtgt tataggggtg cgagggatcg aacgcgttat cgaagttcct      840

atgagtgaca tggaagagag ggtgtttcaa gaatctgcaa aacatcttta taacgccacg      900

agggaagcca ttcgtatcat tgggtggaga gagtcataa                             939


<210>   1397
<211>   300
<212>   PRT
<213>   Clostridium tetani E88

<400>   1397
Lys Ile Ser Ile Ile Gly Ser Gly Phe Val Gly Ser Thr Thr Ala Tyr 
                5                   10                  15      

Ala Leu Met Met Glu Gly Leu Ala Ser Glu Ile Val Ile Val Asp Ile 
            20                  25                  30          

Asn Lys Glu Lys Ala Lys Gly Glu Ala Met Asp Leu Ser His Gly Val 
        35                  40                  45              

Ser Phe Val Lys Pro Val Asp Ile Ile Ala Gly Asp Tyr Glu Asp Thr 
    50                  55                  60                  

Lys Asp Ser Asp Ile Val Ile Ile Thr Ala Gly Ala Gly Pro Lys Pro 
65                  70                  75                  80  

Gly Glu Thr Arg Leu Asp Leu Ile Asn Lys Asn Tyr Glu Ile Phe Lys 
                85                  90                  95      

Gly Ile Val Pro Glu Val Val Lys Tyr Ser Pro Lys Ser Ile Leu Leu 
            100                 105                 110         

Val Val Ser Asn Pro Val Asp Ile Leu Thr Tyr Val Thr Tyr Lys Leu 
        115                 120                 125             

Ser Gly Phe Pro Gln Glu Arg Val Ile Gly Ser Gly Thr Val Leu Asp 
    130                 135                 140                 

Thr Ser Arg Phe Arg Tyr Leu Leu Gly Glu His Phe Lys Ile Asp Val 
145                 150                 155                 160 

Arg Asn Val His Thr Tyr Ile Leu Gly Glu His Gly Asp Ser Glu Ile 
                165                 170                 175     

Ala Ala Trp Ser Leu Thr Asn Ile Ala Gly Ile Ser Val Glu Asp Tyr 
            180                 185                 190         

Cys Lys Asp Ile Cys Lys Gly Cys Glu Gly Asn Phe Lys Asn Arg Ile 
        195                 200                 205             

Pro Glu Glu Val Lys Asn Ala Ala Tyr Glu Val Leu Glu Arg Lys Gly 
    210                 215                 220                 

Tyr Thr Ser Tyr Ala Ile Ala Leu Ala Val Arg Arg Ile Val Glu Ala 
225                 230                 235                 240 

Ile Ile Arg Asp Glu Asp Ser Ile Leu Thr Val Ser Thr Leu Leu Arg 
                245                 250                 255     

Gly Glu Tyr Gly Ile Asn Asp Ile Tyr Met Gly Ile Pro Ser Val Ile 
            260                 265                 270         

Gly Glu Thr Gly Ile Lys Arg Val Leu Glu Val Lys Leu Ser Lys Asp 
        275                 280                 285             

Glu Glu Lys Gln Leu Lys Glu Ser Ala Glu Val Leu 
    290                 295                 300 

<210>   1398
<211>   300
<212>   PRT
<213>   L-lactate dehydrogenase (L-LDH) Score: 270 Significance: 9e-71 Identities: 137/300 Positives: 201/300 Gaps: 10/300

<400>   1398
Lys Ile Ser Ile Ile Gly Ser Gly Phe Val Gly Ser Thr Thr Ala Tyr 
                5                   10                  15      

Ala Leu Met Met Glu Gly Leu Ala Ser Glu Ile Val Ile Val Asp Ile 
            20                  25                  30          

Asn Lys Glu Lys Ala Lys Gly Glu Ala Met Asp Leu Ser His Gly Val 
        35                  40                  45              

Ser Phe Val Lys Pro Val Asp Ile Ile Ala Gly Asp Tyr Glu Asp Thr 
    50                  55                  60                  

Lys Asp Ser Asp Ile Val Ile Ile Thr Ala Gly Ala Gly Pro Lys Pro 
65                  70                  75                  80  

Gly Glu Thr Arg Leu Asp Leu Ile Asn Lys Asn Tyr Glu Ile Phe Lys 
                85                  90                  95      

Gly Ile Val Pro Glu Val Val Lys Tyr Ser Pro Lys Ser Ile Leu Leu 
            100                 105                 110         

Val Val Ser Asn Pro Val Asp Ile Leu Thr Tyr Val Thr Tyr Lys Leu 
        115                 120                 125             

Ser Gly Phe Pro Gln Glu Arg Val Ile Gly Ser Gly Thr Val Leu Asp 
    130                 135                 140                 

Thr Ser Arg Phe Arg Tyr Leu Leu Gly Glu His Phe Lys Ile Asp Val 
145                 150                 155                 160 

Arg Asn Val His Thr Tyr Ile Leu Gly Glu His Gly Asp Ser Glu Ile 
                165                 170                 175     

Ala Ala Trp Ser Leu Thr Asn Ile Ala Gly Ile Ser Val Glu Asp Tyr 
            180                 185                 190         

Cys Lys Asp Ile Cys Lys Gly Cys Glu Gly Asn Phe Lys Asn Arg Ile 
        195                 200                 205             

Pro Glu Glu Val Lys Asn Ala Ala Tyr Glu Val Leu Glu Arg Lys Gly 
    210                 215                 220                 

Tyr Thr Ser Tyr Ala Ile Ala Leu Ala Val Arg Arg Ile Val Glu Ala 
225                 230                 235                 240 

Ile Ile Arg Asp Glu Asp Ser Ile Leu Thr Val Ser Thr Leu Leu Arg 
                245                 250                 255     

Gly Glu Tyr Gly Ile Asn Asp Ile Tyr Met Gly Ile Pro Ser Val Ile 
            260                 265                 270         

Gly Glu Thr Gly Ile Lys Arg Val Leu Glu Val Lys Leu Ser Lys Asp 
        275                 280                 285             

Glu Glu Lys Gln Leu Lys Glu Ser Ala Glu Val Leu 
    290                 295                 300 

<210>   1399
<211>   300
<212>   PRT
<213>   Acidobacteria bacterium Ellin345

<400>   1399
Arg Ile Ala Val Val Gly Leu Gly Asn Val Gly Ala Ser Phe Ala Phe 
                5                   10                  15      

Ala Leu Leu Gln Arg Arg Leu Ala Ala Glu Ile Val Leu Ile Asp Ala 
            20                  25                  30          

Asn His Lys Lys Ala Glu Gly Glu Ala Met Asp Leu Asn His Ala Val 
        35                  40                  45              

Pro Phe Gly Ala Ala Thr Arg Ile Trp Ala Gly Glu Tyr Ala Asp Cys 
    50                  55                  60                  

Arg Gly Ala Ala Val Thr Val Ile Thr Ala Gly Ala Ala Gln Arg Pro 
65                  70                  75                  80  

Gly Glu Thr Arg Leu Gln Leu Leu Asp Arg Asn Leu Ala Ile Phe Gln 
                85                  90                  95      

Gln Ile Val Pro Glu Val Val Lys His Asn Pro Asp Gly Leu Leu Leu 
            100                 105                 110         

Ile Ala Thr Asn Pro Val Asp Ile Ile Ser Tyr Ala Ser Tyr Lys Ile 
        115                 120                 125             

Ser Gly Leu Pro Ala His Arg Val Leu Gly Ser Gly Thr Ile Leu Asp 
    130                 135                 140                 

Thr Ala Arg Phe Arg Tyr Leu Leu Gly Gln His Phe Ser Val Asp Ala 
145                 150                 155                 160 

Arg Ser Val His Gly Leu Ile Leu Gly Glu His Gly Asp Thr Glu Val 
                165                 170                 175     

Pro Ile Trp Ser Leu Ala Asn Ile Ala Gly Ile Arg Leu Arg Glu Tyr 
            180                 185                 190         

Cys Arg Leu His Ser Leu Pro Tyr Asp Glu His Val Phe Asp Thr Ile 
        195                 200                 205             

Phe Thr Asp Thr Arg Asp Ala Ala Tyr Lys Ile Ile Glu Arg Lys Gly 
    210                 215                 220                 

Ala Thr Tyr Tyr Ala Val Ala Val Gly Leu Met Gln Ile Val Glu Ser 
225                 230                 235                 240 

Ile Val Arg Asp Gln Lys Thr Val Leu Thr Thr Ser Thr Leu Val Glu 
                245                 250                 255     

Gly Ala Tyr Gly Ile Asn Asp Val Tyr Leu Ser Leu Pro Thr Ile Val 
            260                 265                 270         

Gly Ala Lys Gly Val Val Gln Val Leu Thr Pro Asp Leu Ser Glu Glu 
        275                 280                 285             

Glu Leu Ala Lys Leu Gln His Ser Ala Glu Val Leu 
    290                 295                 300 

<210>   1400
<211>   303
<212>   PRT
<213>   Chloroflexus aggregans DSM 9485

<400>   1400
Arg Thr Gly Lys Val Gly Val Val Gly Thr Gly Met Val Gly Thr Ser 
                5                   10                  15      

Phe Ala Tyr Ala Leu Met Gln Arg Ser Leu Ala Ser Glu Leu Val Leu 
            20                  25                  30          

Ile Asp Ile Asp Arg Ala Arg Ala Glu Gly Glu Ala Met Asp Leu Asn 
        35                  40                  45              

His Gly Leu Pro Phe Val Arg Pro Met Arg Ile Tyr Ala Gly Asp Tyr 
    50                  55                  60                  

Ala Asp Leu Ala Asp Ala Asp Leu Ile Val Ile Ala Ala Gly Ala Asn 
65                  70                  75                  80  

Gln Arg Pro Gly Glu Thr Arg Leu Asp Leu Leu Gly Arg Asn Ala Ala 
                85                  90                  95      

Ile Phe Arg Asp Met Ile Pro Ala Ile Leu Ala Ala Asn His Asp Gly 
            100                 105                 110         

Ile Ile Val Val Ala Thr Asn Pro Val Asp Ile Leu Thr Thr Ile Ala 
        115                 120                 125             

Ala Gln Ile Ala Gly Ser Asp Ala Asn Arg Val Ile Gly Ser Gly Thr 
    130                 135                 140                 

Ile Leu Asp Thr Ala Arg Phe Arg Tyr Leu Leu Gly Gln His Tyr Gly 
145                 150                 155                 160 

Val Asp Pro Arg Ser Val His Ala Tyr Ile Val Gly Glu His Gly Asp 
                165                 170                 175     

Ser Glu Leu Ala Leu Trp Ser Leu Ala Asn Ile Ala Gly Val Arg Leu 
            180                 185                 190         

Val Asp Phe Val Gly Ala Asn Gly Gln Gly Tyr Asp Gln Ala Ala Leu 
        195                 200                 205             

Asp Ala Ile Leu Glu Gln Thr Arg Asn Ala Ala Tyr Glu Ile Ile Lys 
    210                 215                 220                 

Arg Lys Arg Ala Thr Tyr Tyr Ala Ile Gly Leu Gly Leu Leu Ala Ile 
225                 230                 235                 240 

Ala Glu Ala Val Leu Arg Asp Gln His Thr Val Met Thr Val Ser Ser 
                245                 250                 255     

Leu Met Thr Gly Gln Tyr Gly Val Thr Asp Ile Ala Ile Ser Leu Pro 
            260                 265                 270         

Thr Ile Val Gly Arg Asp Gly Ala Glu Glu Val Leu Asn Leu Pro Leu 
        275                 280                 285             

Ser Asp His Glu Val Ala Leu Phe Gln Arg Ser Ala Asn Leu Leu 
    290                 295                 300             

<210>   1401
<211>   302
<212>   PRT
<213>   Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough

<400>   1401
Met Asn Arg Ile Ala Val Ile Gly Val Gly Asn Val Gly Met Ala Phe 
                5                   10                  15      

Ala Tyr Ala Ala Ala Ile Lys Arg Leu Ala Asn Asp Ile Val Leu Ile 
            20                  25                  30          

Asp Ala Asn Ala Ala Arg Ala Glu Gly Glu Ser Met Asp Leu Ala Asp 
        35                  40                  45              

Ala Met Ala Leu Val Gly Pro Val Gln Ile Arg Ser Gly Gly Tyr Glu 
    50                  55                  60                  

Gln Cys Glu Gly Ala Arg Ile Val Val Val Thr Ala Gly Ala Lys Gln 
65                  70                  75                  80  

Met Pro Gly Gln Ser Arg Leu Asp Leu Val Arg Val Asn Ala Gly Ile 
                85                  90                  95      

Thr Arg Asp Ile Leu Thr Ala Val Met Gln Tyr Ala Asp Asp Pro Leu 
            100                 105                 110         

Tyr Ile Met Ala Thr Asn Pro Val Asp Val Leu Thr His Val Ala Arg 
        115                 120                 125             

Thr Val Thr Gly Val Ala Pro Gly Arg Val Ile Gly Ser Gly Thr Val 
    130                 135                 140                 

Leu Asp Ser Ala Arg Phe Arg Gly His Val Ala Glu Ile Leu Gly Val 
145                 150                 155                 160 

Asp Val Arg Gly Val His Ala His Ile Val Gly Glu His Gly Asp Ser 
                165                 170                 175     

Glu Val Ala Leu Trp Ser Arg Ala Asn Val Ser Gly Ile Pro Val Ala 
            180                 185                 190         

Glu Met Cys Ala Arg Arg Gly Ile Ala Tyr Asp Ala Ala Phe Arg Glu 
        195                 200                 205             

Lys Ala Leu Gly His Val Arg His Ala Ala Tyr Glu Ile Ile Gly Arg 
    210                 215                 220                 

Lys Gly Ala Thr Gly Tyr Gly Ile Gly Met Ser Leu Cys Arg Ile Val 
225                 230                 235                 240 

Glu Ala Ile Leu His Asp Glu His Ser Val Leu Thr Val Ser Cys Pro 
                245                 250                 255     

Val Ala Gly His Tyr Gly Leu Gly Asp Val Ser Leu Ser Leu Pro Cys 
            260                 265                 270         

Val Ile Gly Ser Asp Gly Ile Glu Glu Val Leu Asp Ala Pro Ile Ala 
        275                 280                 285             

Glu Asp Glu Gln Ala Ala Leu Ala Ala Ser Ala Arg Val Leu 
    290                 295                 300         

<210>   1402
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1395

<400>   1402
Met Thr Ile Arg Leu Thr Arg Ile Val Ile Ile Gly Val Gly Ser Val 
                5                   10                  15      

Gly Thr Ala Thr Ala Tyr Thr Leu Tyr Leu Arg Glu Arg Ala Ser Glu 
            20                  25                  30          

Val Val Leu Ile Asp Ala Asp Met Gln Lys Ala Glu Gly Glu Ala Leu 
        35                  40                  45              

Asp Met Gln His Gly Ser Ile Tyr Cys Gly Gly Thr Lys Ile Arg Ala 
    50                  55                  60                  

Gly Thr Tyr Glu Asp Cys Ala Thr Ala Asp Ile Val Ile Val Thr Ala 
65                  70                  75                  80  

Gly Val Ala Gln Arg Pro Gly Gln Ser Arg Ile Asp Leu Leu Val Lys 
                85                  90                  95      

Asn Ile Gln Val Ile Gln Asp Ile Ser Phe Lys Leu Lys Gln Tyr Gly 
            100                 105                 110         

Phe Asn Gly Ile Leu Ile Val Ala Ser Asn Pro Val Asp Ile Leu Ser 
        115                 120                 125             

Tyr Val Ala Trp Tyr Ile Ser Gly Leu Pro Ser Glu Arg Val Ile Gly 
    130                 135                 140                 

Ser Gly Thr Val Leu Asp Ser Leu Arg Phe Arg Tyr Tyr Leu Gly Arg 
145                 150                 155                 160 

Glu Leu Gly Val Asp Pro Gly Ser Val His Ala Gln Val Leu Gly Glu 
                165                 170                 175     

His Gly Asp Thr Gln Val His Ile Trp Ser Ser Leu Asn Val Gly Gly 
            180                 185                 190         

Val Gln Val Pro Ile Ser Glu Arg Ile Arg Gly Val Glu Asp His Thr 
        195                 200                 205             

Arg Arg Ala Ala Tyr Glu Leu Ile Glu His Lys Gly Tyr Thr Asn Tyr 
    210                 215                 220                 

Gly Ile Ala Leu Val Leu Asp Ala Ile Cys Glu Ala Ile Leu Gln Asp 
225                 230                 235                 240 

Lys His Thr Val Leu Thr Val Ser Thr Lys Val Ala Glu Tyr His Gly 
                245                 250                 255     

Val Ser Asp Val Tyr Leu Ser Val Pro Cys Val Ile Gly Val Arg Gly 
            260                 265                 270         

Ile Asp Arg Val Ile Glu Val Pro Met Ser Asp Met Glu Glu Arg Val 
        275                 280                 285             

Phe Gln Glu Ser Ala Lys His Leu Tyr Asn Ala Thr Arg Glu Ala Ile 
    290                 295                 300                 

Arg Ile Ile Gly Trp Arg Glu Ser 
305                 310         

<210>   1403
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1395

<400>   1403
Met Thr Ile Arg Leu Thr Arg Ile Val Ile Ile Gly Val Gly Ser Val 
                5                   10                  15      

Gly Thr Ala Thr Ala Tyr Thr Leu Tyr Leu Arg Glu Arg Ala Ser Glu 
            20                  25                  30          

Val Val Leu Ile Asp Ala Asp Met Gln Lys Ala Glu Gly Glu Ala Leu 
        35                  40                  45              

Asp Met Gln His Gly Ser Ile Tyr Cys Gly Gly Thr Lys Ile Arg Ala 
    50                  55                  60                  

Gly Thr Tyr Glu Asp Cys Ala Thr Ala Asp Ile Val Ile Val Thr Ala 
65                  70                  75                  80  

Gly Val Ala Gln Arg Pro Gly Gln Ser Arg Ile Asp Leu Leu Val Lys 
                85                  90                  95      

Asn Ile Gln Val Ile Gln Asp Ile Ser Phe Lys Leu Lys Gln Tyr Gly 
            100                 105                 110         

Phe Asn Gly Ile Leu Ile Val Ala Ser Asn Pro Val Asp Ile Leu Ser 
        115                 120                 125             

Tyr Val Ala Trp Tyr Ile Ser Gly Leu Pro Ser Glu Arg Val Ile Gly 
    130                 135                 140                 

Ser Gly Thr Val Leu Asp Ser Leu Arg Phe Arg Tyr Tyr Leu Gly Arg 
145                 150                 155                 160 

Glu Leu Gly Val Asp Pro Gly Ser Val His Ala Gln Val Leu Gly Glu 
                165                 170                 175     

His Gly Asp Thr Gln Val His Ile Trp Ser Ser Leu Asn Val Gly Gly 
            180                 185                 190         

Val Gln Val Pro Ile Ser Glu Arg Ile Arg Gly Val Glu Asp His Thr 
        195                 200                 205             

Arg Arg Ala Ala Tyr Glu Leu Ile Glu His Lys Gly Tyr Thr Asn Tyr 
    210                 215                 220                 

Gly Ile Ala Leu Val Leu Asp Ala Ile Cys Glu Ala Ile Leu Gln Asp 
225                 230                 235                 240 

Lys His Thr Val Leu Thr Val Ser Thr Lys Val Ala Glu Tyr His Gly 
                245                 250                 255     

Val Ser Asp Val Tyr Leu Ser Val Pro Cys Val Ile Gly Val Arg Gly 
            260                 265                 270         

Ile Glu Arg Val Ile Glu Val Pro Met Ser Asp Met Glu Glu Arg Val 
        275                 280                 285             

Phe Gln Glu Ser Ala Lys His Leu Tyr Asn Ala Thr Arg Glu Ala Ile 
    290                 295                 300                 

Arg Leu Ile Gly Trp Arg Glu Ser 
305                 310         

<210>   1404
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1395

<400>   1404
Met Thr Ile Arg Leu Thr Arg Ile Val Ile Ile Gly Val Gly Ser Val 
                5                   10                  15      

Gly Thr Ala Thr Ala Tyr Thr Leu Tyr Leu Arg Glu Arg Ala Ser Glu 
            20                  25                  30          

Val Val Leu Ile Asp Ala Asp Met Gln Lys Ala Glu Gly Glu Ala Leu 
        35                  40                  45              

Asp Met Gln His Gly Ser Ile Tyr Cys Gly Gly Thr Lys Ile Arg Ala 
    50                  55                  60                  

Gly Thr Tyr Glu Asp Cys Ala Thr Ala Asp Ile Val Ile Val Thr Ala 
65                  70                  75                  80  

Gly Val Ala Gln Arg Pro Gly Gln Ser Arg Ile Asp Leu Leu Val Lys 
                85                  90                  95      

Asn Ile Gln Val Ile Gln Asp Ile Ser Phe Lys Leu Lys Gln Tyr Gly 
            100                 105                 110         

Phe Asn Gly Ile Leu Ile Val Ala Ser Asn Pro Val Asp Ile Leu Ser 
        115                 120                 125             

Tyr Val Ala Trp Tyr Ile Ser Gly Leu Pro Ser Glu Arg Val Ile Gly 
    130                 135                 140                 

Ser Gly Thr Val Leu Asp Ser Leu Arg Phe Arg Tyr Tyr Leu Gly Arg 
145                 150                 155                 160 

Glu Leu Gly Val Asp Pro Gly Ser Val His Ala Gln Val Leu Gly Glu 
                165                 170                 175     

His Gly Asp Thr Gln Val His Ile Trp Ser Ser Leu Asn Val Gly Gly 
            180                 185                 190         

Val Gln Val Pro Ile Ser Glu Arg Ile Arg Gly Val Glu Asp His Thr 
        195                 200                 205             

Arg Arg Ala Ala Tyr Glu Leu Ile Glu His Lys Gly Tyr Thr Asn Tyr 
    210                 215                 220                 

Gly Ile Ala Leu Val Leu Asp Ala Ile Cys Glu Ala Ile Leu Gln Asp 
225                 230                 235                 240 

Lys His Thr Val Leu Thr Val Ser Thr Lys Val Ala Glu Tyr His Gly 
                245                 250                 255     

Val Ser Asp Val Tyr Leu Ser Val Pro Cys Val Ile Gly Val Arg Gly 
            260                 265                 270         

Ile Glu Arg Val Ile Asp Val Pro Met Ser Asp Met Glu Glu Arg Val 
        275                 280                 285             

Phe Gln Glu Ser Ala Lys His Leu Tyr Asn Ala Thr Arg Glu Ala Ile 
    290                 295                 300                 

Arg Ile Ile Gly Trp Arg Glu Ser 
305                 310         

<210>   1405
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1395

<400>   1405
Met Thr Ile Arg Leu Thr Arg Ile Val Ile Ile Gly Val Gly Ser Val 
                5                   10                  15      

Gly Thr Ala Thr Ala Tyr Thr Leu Tyr Leu Arg Glu Arg Ala Ser Glu 
            20                  25                  30          

Val Val Leu Ile Asp Ala Asp Met Gln Lys Ala Glu Gly Glu Ala Leu 
        35                  40                  45              

Asp Met Gln His Gly Ser Ile Tyr Cys Gly Gly Thr Lys Ile Arg Ala 
    50                  55                  60                  

Gly Thr Tyr Glu Asp Cys Ala Thr Ala Asp Ile Val Ile Val Thr Ala 
65                  70                  75                  80  

Gly Val Ala Gln Arg Pro Gly Gln Ser Arg Ile Asp Leu Leu Val Lys 
                85                  90                  95      

Asn Ile Gln Val Ile Gln Asp Ile Ser Phe Arg Leu Lys Gln Tyr Gly 
            100                 105                 110         

Phe Asn Gly Ile Leu Ile Val Ala Ser Asn Pro Val Asp Ile Leu Ser 
        115                 120                 125             

Tyr Val Ala Trp Tyr Ile Ser Gly Leu Pro Ser Glu Arg Val Ile Gly 
    130                 135                 140                 

Ser Gly Thr Val Leu Asp Ser Leu Arg Phe Arg Tyr Tyr Leu Gly Arg 
145                 150                 155                 160 

Glu Leu Gly Val Asp Pro Gly Ser Val His Ala Gln Val Leu Gly Glu 
                165                 170                 175     

His Gly Asp Thr Gln Val His Ile Trp Ser Ser Leu Asn Val Gly Gly 
            180                 185                 190         

Val Gln Val Pro Ile Ser Glu Arg Ile Arg Gly Val Glu Asp His Thr 
        195                 200                 205             

Arg Arg Ala Ala Tyr Glu Leu Ile Glu His Lys Gly Tyr Thr Asn Tyr 
    210                 215                 220                 

Gly Ile Ala Leu Val Leu Asp Ala Ile Cys Glu Ala Ile Leu Gln Asp 
225                 230                 235                 240 

Lys His Thr Val Leu Thr Val Ser Thr Lys Val Ala Glu Tyr His Gly 
                245                 250                 255     

Val Ser Asp Val Tyr Leu Ser Val Pro Cys Val Ile Gly Val Arg Gly 
            260                 265                 270         

Ile Glu Arg Val Ile Glu Val Pro Met Ser Asp Met Glu Glu Arg Val 
        275                 280                 285             

Phe Gln Glu Ser Ala Lys His Leu Tyr Asn Ala Thr Arg Glu Ala Ile 
    290                 295                 300                 

Arg Ile Ile Gly Trp Arg Glu Ser 
305                 310         

<210>   1406
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1395

<400>   1406
Met Thr Ile Arg Leu Thr Arg Ile Val Ile Ile Gly Val Gly Ser Val 
                5                   10                  15      

Gly Thr Ala Thr Ala Tyr Thr Leu Tyr Leu Arg Glu Arg Ala Ser Glu 
            20                  25                  30          

Val Val Leu Ile Asp Ala Asp Met Gln Lys Ala Glu Gly Glu Ala Leu 
        35                  40                  45              

Asp Met Gln His Gly Ser Ile Tyr Cys Gly Gly Thr Lys Ile Arg Ala 
    50                  55                  60                  

Gly Thr Tyr Glu Asp Cys Ala Thr Ala Asp Ile Val Ile Val Thr Ala 
65                  70                  75                  80  

Gly Val Ala Gln Arg Pro Gly Gln Ser Arg Ile Asp Leu Leu Val Lys 
                85                  90                  95      

Asn Ile Gln Val Leu Gln Asp Ile Ser Phe Lys Leu Lys Gln Tyr Gly 
            100                 105                 110         

Phe Asn Gly Ile Leu Ile Val Ala Ser Asn Pro Val Asp Ile Leu Ser 
        115                 120                 125             

Tyr Val Ala Trp Tyr Ile Ser Gly Leu Pro Ser Glu Arg Val Ile Gly 
    130                 135                 140                 

Ser Gly Thr Val Leu Asp Ser Leu Arg Phe Arg Tyr Tyr Leu Gly Arg 
145                 150                 155                 160 

Glu Leu Gly Val Asp Pro Gly Ser Val His Ala Gln Val Leu Gly Glu 
                165                 170                 175     

His Gly Asp Thr Gln Val His Ile Trp Ser Ser Leu Asn Val Gly Gly 
            180                 185                 190         

Val Gln Val Pro Ile Ser Glu Arg Ile Arg Gly Val Glu Asp His Thr 
        195                 200                 205             

Arg Arg Ala Ala Tyr Glu Leu Ile Glu His Lys Gly Tyr Thr Asn Tyr 
    210                 215                 220                 

Gly Ile Ala Leu Val Leu Asp Ala Ile Cys Glu Ala Ile Leu Gln Asp 
225                 230                 235                 240 

Lys His Thr Val Leu Thr Val Ser Thr Lys Val Ala Glu Tyr His Gly 
                245                 250                 255     

Val Ser Asp Val Tyr Leu Ser Val Pro Cys Val Ile Gly Val Arg Gly 
            260                 265                 270         

Ile Glu Arg Val Ile Glu Val Pro Met Ser Asp Met Glu Glu Arg Val 
        275                 280                 285             

Phe Gln Glu Ser Ala Lys His Leu Tyr Asn Ala Thr Arg Glu Ala Ile 
    290                 295                 300                 

Arg Ile Ile Gly Trp Arg Glu Ser 
305                 310         

<210>   1407
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1396

<400>   1407
atgacaatac gattgactcg gattgtgata attggagtgg gttctgtagg aacagccact       60

gcttacacac tatatttacg ggaacgagca tcagaagtcg tcttaattga tgcggatatg      120

caaaaagcgg aaggcgaagc tctagatatg caacacggta gtatttattg cggtgggacg      180

aaaatccgcg cgggtacata tgaggactgt gcaacagcag acatcgtaat tgtcacggct      240

ggagtggctc agaggcctgg acaatcacgt attgacctct tggtgaagaa tatacaagtt      300

attcaggata tttcttttaa actaaaacaa tatggtttta atggaattct cattgttgca      360

tccaatcccg tagatatact tagctatgtc gcatggtata tttcgggctt gccatctgaa      420

cgggtaatag gatcagggac tgtcttggat tcgctcaggt tccgatatta ccttggtaga      480

gaattggggg tcgatcctgg gagtgtccat gcacaggtgc taggcgaaca tggtgacacg      540

caagttcaca tatggagtag tttgaatgtt ggtggagttc aggtgccaat atctgaaagg      600

attaggggcg tcgaggacca tacgcgtcga gctgcttatg aattaattga acacaaaggt      660

tacacaaatt atggaatcgc attagtgctc gatgcaatct gcgaagctat attacaggac      720

aaacatacgg ttttgactgt ttcaacaaaa gtagcagaat atcacggggt atcggatgtt      780

tatttgagtg ttccgtgtgt tataggggtg cgagggatcg atcgcgttat cgaagttcct      840

atgagtgaca tggaagagag ggtgtttcaa gaatctgcaa aacatcttta taacgccacg      900

agggaagcca ttcgtatcat tgggtggaga gagtcataa                             939


<210>   1408
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1396

<400>   1408
atgacaatac gattgactcg gattgtgata attggagtgg gttctgtagg aacagccact       60

gcttacacac tatatttacg ggaacgagca tcagaagtcg tcttaattga tgcggatatg      120

caaaaagcgg aaggcgaagc tctagatatg caacacggta gtatttattg cggtgggacg      180

aaaatccgcg cgggtacata tgaggactgt gcaacagcag acatcgtaat tgtcacggct      240

ggagtggctc agaggcctgg acaatcacgt attgacctct tggtgaagaa tatacaagtt      300

attcaggata tttcttttaa actaaaacaa tatggtttta atggaattct cattgttgca      360

tccaatcccg tagatatact tagctatgtc gcatggtata tttcgggctt gccatctgaa      420

cgggtaatag gatcagggac tgtcttggat tcgctcaggt tccgatatta ccttggtaga      480

gaattggggg tcgatcctgg gagtgtccat gcacaggtgc taggcgaaca tggtgacacg      540

caagttcaca tatggagtag tttgaatgtt ggtggagttc aggtgccaat atctgaaagg      600

attaggggcg tcgaggacca tacgcgtcga gctgcttatg aattaattga acacaaaggt      660

tacacaaatt atggaatcgc attagtgctc gatgcaatct gcgaagctat attacaggac      720

aaacatacgg ttttgactgt ttcaacaaaa gtagcagaat atcacggggt atcggatgtt      780

tatttgagtg ttccgtgtgt tataggggtg cgagggatcg aacgcgttat cgaagttcct      840

atgagtgaca tggaagagag ggtgtttcaa gaatctgcaa aacatcttta taacgccacg      900

agggaagcca ttcgtttaat tgggtggaga gagtcataa                             939


<210>   1409
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1396

<400>   1409
atgacaatac gattgactcg gattgtgata attggagtgg gttctgtagg aacagccact       60

gcttacacac tatatttacg ggaacgagca tcagaagtcg tcttaattga tgcggatatg      120

caaaaagcgg aaggcgaagc tctagatatg caacacggta gtatttattg cggtgggacg      180

aaaatccgcg cgggtacata tgaggactgt gcaacagcag acatcgtaat tgtcacggct      240

ggagtggctc agaggcctgg acaatcacgt attgacctct tggtgaagaa tatacaagtt      300

attcaggata tttcttttaa actaaaacaa tatggtttta atggaattct cattgttgca      360

tccaatcccg tagatatact tagctatgtc gcatggtata tttcgggctt gccatctgaa      420

cgggtaatag gatcagggac tgtcttggat tcgctcaggt tccgatatta ccttggtaga      480

gaattggggg tcgatcctgg gagtgtccat gcacaggtgc taggcgaaca tggtgacacg      540

caagttcaca tatggagtag tttgaatgtt ggtggagttc aggtgccaat atctgaaagg      600

attaggggcg tcgaggacca tacgcgtcga gctgcttatg aattaattga acacaaaggt      660

tacacaaatt atggaatcgc attagtgctc gatgcaatct gcgaagctat attacaggac      720

aaacatacgg ttttgactgt ttcaacaaaa gtagcagaat atcacggggt atcggatgtt      780

tatttgagtg ttccgtgtgt tataggggtg cgagggatcg aacgcgttat cgatgttcct      840

atgagtgaca tggaagagag ggtgtttcaa gaatctgcaa aacatcttta taacgccacg      900

agggaagcca ttcgtatcat tgggtggaga gagtcataa                             939


<210>   1410
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1396

<400>   1410
atgacaatac gattgactcg gattgtgata attggagtgg gttctgtagg aacagccact       60

gcttacacac tatatttacg ggaacgagca tcagaagtcg tcttaattga tgcggatatg      120

caaaaagcgg aaggcgaagc tctagatatg caacacggta gtatttattg cggtgggacg      180

aaaatccgcg cgggtacata tgaggactgt gcaacagcag acatcgtaat tgtcacggct      240

ggagtggctc agaggcctgg acaatcacgt attgacctct tggtgaagaa tatacaagtt      300

attcaggata tttcttttcg tctaaaacaa tatggtttta atggaattct cattgttgca      360

tccaatcccg tagatatact tagctatgtc gcatggtata tttcgggctt gccatctgaa      420

cgggtaatag gatcagggac tgtcttggat tcgctcaggt tccgatatta ccttggtaga      480

gaattggggg tcgatcctgg gagtgtccat gcacaggtgc taggcgaaca tggtgacacg      540

caagttcaca tatggagtag tttgaatgtt ggtggagttc aggtgccaat atctgaaagg      600

attaggggcg tcgaggacca tacgcgtcga gctgcttatg aattaattga acacaaaggt      660

tacacaaatt atggaatcgc attagtgctc gatgcaatct gcgaagctat attacaggac      720

aaacatacgg ttttgactgt ttcaacaaaa gtagcagaat atcacggggt atcggatgtt      780

tatttgagtg ttccgtgtgt tataggggtg cgagggatcg aacgcgttat cgaagttcct      840

atgagtgaca tggaagagag ggtgtttcaa gaatctgcaa aacatcttta taacgccacg      900

agggaagcca ttcgtatcat tgggtggaga gagtcataa                             939


<210>   1411
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1396

<400>   1411
atgacaatac gattgactcg gattgtgata attggagtgg gttctgtagg aacagccact       60

gcttacacac tatatttacg ggaacgagca tcagaagtcg tcttaattga tgcggatatg      120

caaaaagcgg aaggcgaagc tctagatatg caacacggta gtatttattg cggtgggacg      180

aaaatccgcg cgggtacata tgaggactgt gcaacagcag acatcgtaat tgtcacggct      240

ggagtggctc agaggcctgg acaatcacgt attgacctct tggtgaagaa tatacaagtt      300

ttacaggata tttcttttaa actaaaacaa tatggtttta atggaattct cattgttgca      360

tccaatcccg tagatatact tagctatgtc gcatggtata tttcgggctt gccatctgaa      420

cgggtaatag gatcagggac tgtcttggat tcgctcaggt tccgatatta ccttggtaga      480

gaattggggg tcgatcctgg gagtgtccat gcacaggtgc taggcgaaca tggtgacacg      540

caagttcaca tatggagtag tttgaatgtt ggtggagttc aggtgccaat atctgaaagg      600

attaggggcg tcgaggacca tacgcgtcga gctgcttatg aattaattga acacaaaggt      660

tacacaaatt atggaatcgc attagtgctc gatgcaatct gcgaagctat attacaggac      720

aaacatacgg ttttgactgt ttcaacaaaa gtagcagaat atcacggggt atcggatgtt      780

tatttgagtg ttccgtgtgt tataggggtg cgagggatcg aacgcgttat cgaagttcct      840

atgagtgaca tggaagagag ggtgtttcaa gaatctgcaa aacatcttta taacgccacg      900

agggaagcca ttcgtatcat tgggtggaga gagtcataa                             939


<210>   1412
<211>   427
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1412
Met Thr Tyr Phe Lys Thr Ala Ala Glu Leu Glu Gln His Trp Lys Thr 
                5                   10                  15      

Asp Pro Arg Trp Lys Gly Val Glu Arg Ala Tyr Thr Ala Glu Asp Val 
            20                  25                  30          

Ile Arg Leu Arg Gly Ser Val His Ile Glu His Thr Leu Ala Gln Met 
        35                  40                  45              

Gly Ala Glu Lys Leu Trp Arg Gly Leu His Glu Asp Gly Phe Ile Arg 
    50                  55                  60                  

Ala Leu Gly Ala Leu Thr Gly Asn Gln Ala Val Gln Gln Val Lys Ala 
65                  70                  75                  80  

Gly Leu Lys Ala Ile Tyr Val Ser Gly Trp Gln Val Ala Ala Asp Ala 
                85                  90                  95      

Asn Leu Ala Glu His Met Tyr Pro Asp Gln Ser Leu Tyr Pro Ser Asn 
            100                 105                 110         

Ser Val Pro Ser Leu Val Arg Arg Ile Asn Asn Ala Leu Leu Arg Ala 
        115                 120                 125             

Asp Gln Ile Gln Thr Ala Glu Gly Lys Gly Asp Ile Asp Trp Met Val 
    130                 135                 140                 

Pro Ile Val Ala Asp Ala Glu Ala Gly Phe Gly Gly Pro Leu Asn Val 
145                 150                 155                 160 

Phe Glu Leu Met Lys Met Met Ile Glu Ala Gly Ala Ala Gly Val His 
                165                 170                 175     

Phe Glu Asp Gln Leu Ser Ser Glu Lys Lys Cys Gly His Met Gly Gly 
            180                 185                 190         

Lys Val Leu Ile Pro Thr Ser His Ala Val Arg Asn Leu Thr Ala Ala 
        195                 200                 205             

Arg Leu Ala Ala Asp Val Leu Gly Val Pro Thr Val Ile Val Ala Arg 
    210                 215                 220                 

Thr Asp Ala Asn Gly Ala Phe Leu Ile Thr Ser Asp Val Asp Asp Arg 
225                 230                 235                 240 

Asp Ala Arg Phe Ile Thr Gly Glu Arg Thr Pro Glu Gly Phe Tyr Arg 
                245                 250                 255     

Phe Arg Gly Gly Leu Glu Ala Ala Ile Ala Arg Gly Leu Ala Tyr Ala 
            260                 265                 270         

Pro Tyr Ala Asp Met Ile Trp Cys Glu Thr Ser Glu Pro Asn Ile Glu 
        275                 280                 285             

Glu Ala Lys Arg Phe Ala Glu Ala Ile Lys Ala Glu Phe Pro Asp Lys 
    290                 295                 300                 

Leu Leu Ala Tyr Asn Cys Ser Pro Ser Phe Asn Trp Arg Lys Lys Leu 
305                 310                 315                 320 

Asp Pro Lys Thr Ile Glu Glu Phe Gln Glu Ile Ile Ala Ser Phe Gly 
                325                 330                 335     

Tyr Lys Phe Gln Phe Val Thr Leu Ala Gly Phe His Ala Leu Asn Tyr 
            340                 345                 350         

Ser Met Phe Glu Leu Ala Tyr Gly Tyr Asn Gln Arg Gly Met Gly Ala 
        355                 360                 365             

Tyr Ser Asp Leu Gln Gln Gln Glu Phe Ala Ala Glu Ala Arg Gly Tyr 
    370                 375                 380                 

Thr Ala Thr Arg His Gln Arg Glu Val Gly Thr Gly Tyr Phe Asp Glu 
385                 390                 395                 400 

Val Ala Gln Val Val Ser Gly Gly Leu Ser Ser Thr Thr Ala Leu Thr 
                405                 410                 415     

Gly Ser Thr Glu Glu Glu Gln Phe Val Glu Ala 
            420                 425         

<210>   1413
<211>   1284
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1413
atgacatact tcaaaacggc ggcggaactg gagcagcatt ggaagacgga tcctcgttgg       60

aaaggcgtcg agcgcgccta tacggccgaa gacgtgattc ggctcagggg atcggtgcac      120

attgaacaca cactcgcgca gatgggcgcg gagaagctgt ggcggggtct ccatgaagac      180

ggcttcattc gcgcgctcgg tgccctgacc ggcaaccagg ccgtgcaaca ggtgaaagcg      240

gggctgaagg ccatctacgt cagcggctgg caggtggcgg cggacgccaa cctggctgag      300

catatgtacc cggatcagag cctgtatccg tccaacagcg tgccgagcct cgtgcggcgc      360

atcaacaacg cgctgttgcg cgcggatcag attcagaccg cggaaggcaa gggcgacatc      420

gactggatgg tgccgattgt ggccgacgcc gaggcaggct tcggcgggcc gctgaacgtg      480

ttcgaactca tgaagatgat gattgaggcc ggcgccgcgg gcgttcactt cgaagatcag      540

ctgtcatcgg agaagaagtg cggtcacatg ggcggcaagg tgctcatccc cacgtcgcac      600

gcggtgcgga atctgacggc cgcccgtctc gctgccgatg tgctcggcgt gccgacggtc      660

atcgtggcgc gcacagacgc caacggcgcg ttcctcatca cgagcgatgt cgacgatcgc      720

gacgcgcggt tcatcaccgg cgagcgcacg ccggaagggt tctaccggtt ccggggcggg      780

ctggaggccg caattgcccg cggactcgct tatgcgccgt acgcggacat gatctggtgc      840

gagacgtccg agccgaacat cgaggaagcg aagcggtttg cggaggccat caaggccgaa      900

ttcccggata aacttctggc ctacaactgc tcgccctctt tcaactggcg gaagaagctc      960

gatccgaaga ccatcgagga gttccaggag atcatcgcgt cgttcggcta caagttccag     1020

ttcgtgaccc tggcgggctt ccacgccctc aactacagca tgttcgagct cgcgtatggc     1080

tacaaccagc gcggcatggg ggcgtactcg gacctgcagc agcaggagtt cgcggcggag     1140

gcccgtggct acacggcgac acgccatcag cgggaggtgg gcacgggcta cttcgatgaa     1200

gtggcgcagg tggtgtcggg cgggctctcg tccacgacgg cgctcaccgg ctccacggag     1260

gaggagcagt ttgtggaggc gtga                                            1284


<210>   1414
<211>   404
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1414
Ser Phe Ala Glu Arg Val Arg Gln Leu Glu Glu Ser Trp Lys Asn Glu 
                5                   10                  15      

Glu Arg Trp Lys Gly Val Val Arg Pro Tyr Ser Ala Glu Asp Val Ile 
            20                  25                  30          

Lys Leu Arg Gly Ser Leu Asp Ile Glu His Thr Leu Ala Arg Arg Gly 
        35                  40                  45              

Ala Glu Lys Leu Trp Lys Leu Leu Asn Thr Glu Asp Tyr Val His Ala 
    50                  55                  60                  

Leu Gly Ala Leu Thr Gly Asn Gln Ala Val Gln Gln Val Lys Ala Gly 
65                  70                  75                  80  

Leu Lys Ala Ile Tyr Leu Ser Gly Trp Gln Val Ala Ala Asp Ala Asn 
                85                  90                  95      

Leu Ala Gly His Met Tyr Pro Asp Gln Ser Leu Tyr Pro Ser Asn Ser 
            100                 105                 110         

Val Pro His Val Val Lys Arg Ile Asn Gln Ala Leu Gln Arg Ala Asp 
        115                 120                 125             

Gln Ile Gln Tyr Leu Glu Gly Ser Gly Asp Val Asp Tyr Phe Val Pro 
    130                 135                 140                 

Ile Val Ala Asp Ala Glu Ala Gly Phe Gly Gly Gln Leu Asn Val Phe 
145                 150                 155                 160 

Glu Leu Met Lys Ala Met Ile Glu Ala Gly Ala Ala Gly Val His Phe 
                165                 170                 175     

Glu Asp Gln Leu Ser Ser Glu Lys Lys Cys Gly His Leu Gly Gly Lys 
            180                 185                 190         

Val Leu Leu Pro Thr Gln Thr Ala Val Arg Asn Leu Ile Ala Ala Arg 
        195                 200                 205             

Leu Ala Ala Asp Val Met Gly Val Pro Thr Val Leu Ile Ala Arg Thr 
    210                 215                 220                 

Asp Ala Asn Ala Ala Asp Leu Ile Thr Ser Asp Ile Asp Pro Arg Asp 
225                 230                 235                 240 

Gln Gln Phe Ile Thr Gly Glu Arg Thr Thr Glu Gly Phe Tyr Arg Thr 
                245                 250                 255     

Arg Ala Gly Leu Asp Gln Ala Ile Ala Arg Gly Leu Ala Tyr Ala Pro 
            260                 265                 270         

Tyr Ala Asp Leu Ile Trp Cys Glu Thr Ser Glu Pro Asn Leu Asp Glu 
        275                 280                 285             

Ala Arg Arg Phe Ala Glu Ala Ile His Glu Gln Phe Pro Gly Lys Leu 
    290                 295                 300                 

Leu Ala Tyr Asn Cys Ser Pro Ser Phe Asn Trp Lys Lys Lys Leu Asp 
305                 310                 315                 320 

Asp Glu Thr Ile Ala Lys Phe Gln Gln Glu Leu Gly Lys Met Gly Tyr 
                325                 330                 335     

Lys Phe Gln Phe Val Thr Leu Ala Gly Phe His Ala Leu Asn Tyr Ser 
            340                 345                 350         

Met Phe Glu Leu Ala Arg Gly Tyr Lys Asp Arg Gly Met Ala Ala Tyr 
        355                 360                 365             

Ala Glu Leu Gln Gln Ala Glu Phe Ala Ala Glu Lys Tyr Gly Tyr Thr 
    370                 375                 380                 

Ala Thr Arg His Gln Arg Glu Val Gly Thr Gly Tyr Phe Asp Glu Val 
385                 390                 395                 400 

Ala Gln Val Ile 
                

<210>   1415
<211>   404
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1415
Ser Phe Ala Glu Arg Val Arg Gln Leu Glu Glu Ser Trp Lys Asn Glu 
                5                   10                  15      

Glu Arg Trp Lys Gly Ile Val Arg Pro Tyr Ser Ala Glu Asp Val Ile 
            20                  25                  30          

Lys Leu Arg Gly Ser Leu Asp Ile Glu Tyr Thr Leu Ala Arg Arg Gly 
        35                  40                  45              

Ala Glu Lys Leu Trp Lys Leu Leu His Thr Glu Asp Tyr Val Ala Ala 
    50                  55                  60                  

Leu Gly Ala Leu Thr Gly Asn Gln Ala Val Gln Gln Val Lys Ala Gly 
65                  70                  75                  80  

Leu Lys Ala Ile Tyr Leu Ser Gly Trp Gln Val Ala Ala Asp Ala Asn 
                85                  90                  95      

Leu Ala Gly Gln Met Tyr Pro Asp Gln Ser Leu Tyr Pro Ser Asn Ser 
            100                 105                 110         

Val Pro His Val Val Lys Arg Ile Asn Gln Ala Leu Gln Arg Ala Asp 
        115                 120                 125             

Gln Ile Gln Tyr Leu Glu Gly Ser Gly Asp Val Asp Tyr Phe Val Pro 
    130                 135                 140                 

Ile Val Ala Asp Ala Glu Ala Gly Phe Gly Gly Gln Leu Asn Val Phe 
145                 150                 155                 160 

Glu Leu Met Lys Ala Met Ile Glu Ala Gly Ala Ala Gly Val His Phe 
                165                 170                 175     

Glu Asp Gln Leu Ser Ser Glu Lys Lys Cys Gly His Leu Gly Gly Lys 
            180                 185                 190         

Val Leu Leu Pro Thr Gln Thr Ala Ile Arg Asn Leu Ile Ala Ala Arg 
        195                 200                 205             

Leu Ala Ala Asp Val Met Gly Val Pro Thr Val Leu Ile Ala Arg Thr 
    210                 215                 220                 

Asp Ala Asn Ala Ala Asp Leu Ile Thr Ser Asp Ile Asp Pro Arg Asp 
225                 230                 235                 240 

Gln Ala Phe Ile Thr Gly Glu Arg Thr Pro Glu Gly Phe Tyr Arg Thr 
                245                 250                 255     

Arg Ala Gly Leu Asp Gln Ala Ile Ala Arg Gly Leu Ala Tyr Ala Pro 
            260                 265                 270         

Tyr Ala Asp Leu Ile Trp Cys Glu Thr Ser Glu Pro Asn Leu Asp Glu 
        275                 280                 285             

Ala Arg Arg Phe Ala Glu Ala Ile His Glu Lys Phe Pro Gly Lys Leu 
    290                 295                 300                 

Leu Ala Tyr Asn Cys Ser Pro Ser Phe Asn Trp Lys Lys Lys Leu Asp 
305                 310                 315                 320 

Asp Glu Thr Ile Ala Lys Phe Gln Gln Glu Leu Gly Lys Met Gly Tyr 
                325                 330                 335     

Lys Phe Gln Phe Val Thr Leu Ala Gly Phe His Ala Leu Asn Tyr Ser 
            340                 345                 350         

Met Phe Glu Leu Ala Arg Gly Tyr Lys Glu Arg Gly Met Ala Ala Tyr 
        355                 360                 365             

Ala Glu Leu Gln Gln Ala Glu Phe Ala Ala Glu Lys Tyr Gly Tyr Thr 
    370                 375                 380                 

Ala Thr Arg His Gln Arg Glu Val Gly Thr Gly Tyr Phe Asp Glu Val 
385                 390                 395                 400 

Ala Gln Val Ile 
                

<210>   1416
<211>   397
<212>   PRT
<213>   Bacillus cereus ATCC 10987

<400>   1416
Lys Leu Gln Glu Ser Trp Glu Leu Asp Thr Arg Trp Lys Gly Ile Thr 
                5                   10                  15      

Arg Pro Tyr Ser Ala Glu Asp Val Ile Arg Leu Arg Gly Ser Ile Asp 
            20                  25                  30          

Ile Glu His Thr Leu Ala Arg Arg Gly Ala Glu Lys Leu Trp Ala Ser 
        35                  40                  45              

Leu His Thr Glu Asp Tyr Ile Asn Ala Leu Gly Ala Leu Thr Gly Asn 
    50                  55                  60                  

Gln Ala Met Gln Gln Val Lys Ala Gly Leu Lys Ala Ile Tyr Leu Ser 
65                  70                  75                  80  

Gly Trp Gln Val Ala Ala Asp Ala Asn Leu Ser Gly His Met Tyr Pro 
                85                  90                  95      

Asp Gln Ser Leu Tyr Pro Ala Asn Ser Val Pro Ala Val Val Lys Arg 
            100                 105                 110         

Ile Asn Gln Thr Leu Gln Arg Ala Asp Gln Ile Gln His Met Glu Gly 
        115                 120                 125             

Ser Gly Asp Thr Asp Tyr Phe Val Pro Ile Val Ala Asp Ala Glu Ala 
    130                 135                 140                 

Gly Phe Gly Gly Gln Leu Asn Val Phe Glu Leu Met Lys Gly Met Ile 
145                 150                 155                 160 

Glu Ala Gly Ala Ser Gly Val His Phe Glu Asp Gln Leu Ser Ser Glu 
                165                 170                 175     

Lys Lys Cys Gly His Leu Gly Gly Lys Val Leu Leu Pro Thr Gln Thr 
            180                 185                 190         

Ala Val Arg Asn Leu Ile Ser Ala Arg Leu Ala Ala Asp Val Met Gly 
        195                 200                 205             

Val Pro Thr Ile Ile Val Ala Arg Thr Asp Ala Asp Ala Ala Asp Leu 
    210                 215                 220                 

Ile Thr Ser Asp Ile Asp Pro Val Asp Lys Ala Phe Ile Thr Gly Glu 
225                 230                 235                 240 

Arg Thr Pro Glu Gly Phe Tyr Arg Thr Lys Ala Gly Leu Asp Gln Ala 
                245                 250                 255     

Ile Ala Arg Gly Leu Ala Tyr Ala Pro Tyr Ala Asp Leu Val Trp Cys 
            260                 265                 270         

Glu Thr Ser Glu Pro Asn Leu Glu Asp Ala Lys Arg Phe Ala Glu Ala 
        275                 280                 285             

Ile His Lys Glu His Pro Gly Lys Leu Leu Ala Tyr Asn Cys Ser Pro 
    290                 295                 300                 

Ser Phe Asn Trp Lys Gln Lys Leu Asp Glu Lys Thr Ile Ala Ser Phe 
305                 310                 315                 320 

Gln Lys Glu Ile Ala Ser Tyr Gly Tyr Lys Phe Gln Phe Val Thr Leu 
                325                 330                 335     

Ala Gly Phe His Ser Leu Asn Tyr Gly Met Phe Glu Leu Ala Arg Gly 
            340                 345                 350         

Tyr Lys Glu Arg Gly Met Ala Ala Tyr Ser Glu Leu Gln Gln Ala Glu 
        355                 360                 365             

Phe Ala Ala Glu Lys His Gly Tyr Ser Ala Thr Arg His Gln Arg Glu 
    370                 375                 380                 

Val Gly Thr Gly Tyr Phe Asp Glu Val Ala Gln Val Ile 
385                 390                 395         

<210>   1417
<211>   397
<212>   PRT
<213>   Bacillus thuringiensis str. Al Hakam

<400>   1417
Lys Leu Gln Glu Ser Trp Glu Leu Asp Thr Arg Trp Lys Gly Ile Thr 
                5                   10                  15      

Arg Pro Tyr Ser Ala Glu Asp Val Ile Arg Leu Arg Gly Ser Ile Asp 
            20                  25                  30          

Ile Glu His Thr Leu Ala Arg Arg Gly Ala Glu Lys Leu Trp Ala Ser 
        35                  40                  45              

Leu His Thr Glu Asp Tyr Ile Asn Ala Leu Gly Ala Leu Thr Gly Asn 
    50                  55                  60                  

Gln Ala Met Gln Gln Val Lys Ala Gly Leu Lys Ala Ile Tyr Leu Ser 
65                  70                  75                  80  

Gly Trp Gln Val Ala Ala Asp Ala Asn Leu Ser Gly His Met Tyr Pro 
                85                  90                  95      

Asp Gln Ser Leu Tyr Pro Ala Asn Ser Val Pro Ala Val Val Lys Arg 
            100                 105                 110         

Ile Asn Gln Thr Leu Gln Arg Ala Asp Gln Ile Gln His Met Glu Gly 
        115                 120                 125             

Ser Gly Asp Thr Asp Tyr Phe Val Pro Ile Val Ala Asp Ala Glu Ala 
    130                 135                 140                 

Gly Phe Gly Gly Gln Leu Asn Val Phe Glu Leu Met Lys Gly Met Ile 
145                 150                 155                 160 

Glu Ala Gly Ala Ser Gly Val His Phe Glu Asp Gln Leu Ser Ser Glu 
                165                 170                 175     

Lys Lys Cys Gly His Leu Gly Gly Lys Val Leu Leu Pro Thr Gln Thr 
            180                 185                 190         

Ala Val Arg Asn Leu Ile Ser Ala Arg Leu Ala Ala Asp Val Met Gly 
        195                 200                 205             

Val Pro Thr Ile Ile Val Ala Arg Thr Asp Ala Asp Ala Ala Asp Leu 
    210                 215                 220                 

Ile Thr Ser Asp Ile Asp Pro Val Asp Lys Ala Phe Ile Thr Gly Glu 
225                 230                 235                 240 

Arg Thr Pro Glu Gly Phe Tyr Arg Thr Lys Ala Gly Leu Asp Gln Ala 
                245                 250                 255     

Ile Ala Arg Gly Leu Ala Tyr Ala Pro Tyr Ala Asp Leu Val Trp Cys 
            260                 265                 270         

Glu Thr Ser Glu Pro Asn Leu Glu Asp Ala Lys Arg Phe Ala Asp Ala 
        275                 280                 285             

Ile His Lys Glu His Pro Gly Lys Leu Leu Ala Tyr Asn Cys Ser Pro 
    290                 295                 300                 

Ser Phe Asn Trp Lys Gln Lys Leu Asp Glu Lys Thr Ile Ala Ser Phe 
305                 310                 315                 320 

Gln Lys Glu Ile Ala Ser Tyr Gly Tyr Lys Phe Gln Phe Val Thr Leu 
                325                 330                 335     

Ala Gly Phe His Ser Leu Asn Tyr Gly Met Phe Glu Leu Ala Arg Gly 
            340                 345                 350         

Tyr Lys Glu Arg Gly Met Ala Ala Tyr Ser Glu Leu Gln Gln Ala Glu 
        355                 360                 365             

Phe Ala Ala Glu Lys His Gly Tyr Ser Ala Thr Arg His Gln Arg Glu 
    370                 375                 380                 

Val Gly Thr Gly Tyr Phe Asp Glu Val Ala Gln Val Ile 
385                 390                 395         

<210>   1418
<211>   397
<212>   PRT
<213>   Bacillus anthracis str. Ames

<400>   1418
Lys Leu Gln Glu Ser Trp Glu Leu Asp Thr Arg Trp Lys Gly Ile Thr 
                5                   10                  15      

Arg Pro Tyr Ser Ala Glu Asp Val Ile Arg Leu Arg Gly Ser Ile Asp 
            20                  25                  30          

Ile Glu His Thr Leu Ala Arg Arg Gly Ala Glu Lys Leu Trp Ala Ser 
        35                  40                  45              

Leu His Thr Glu Asp Tyr Ile Asn Ala Leu Gly Ala Leu Thr Gly Asn 
    50                  55                  60                  

Gln Ala Met Gln Gln Val Lys Ala Gly Leu Lys Ala Ile Tyr Leu Ser 
65                  70                  75                  80  

Gly Trp Gln Val Ala Ala Asp Ala Asn Leu Ser Gly His Met Tyr Pro 
                85                  90                  95      

Asp Gln Ser Leu Tyr Pro Ala Asn Ser Val Pro Ala Val Val Lys Arg 
            100                 105                 110         

Ile Asn Gln Thr Leu Gln Arg Ala Asp Gln Ile Gln His Met Glu Gly 
        115                 120                 125             

Ser Gly Asp Thr Asp Tyr Phe Val Pro Ile Val Ala Asp Ala Glu Ala 
    130                 135                 140                 

Gly Phe Gly Gly Gln Leu Asn Val Phe Glu Leu Met Lys Gly Met Ile 
145                 150                 155                 160 

Glu Ala Gly Ala Ser Gly Val His Phe Glu Asp Gln Leu Ser Ser Glu 
                165                 170                 175     

Lys Lys Cys Gly His Leu Gly Gly Lys Val Leu Leu Pro Thr Gln Thr 
            180                 185                 190         

Ala Val Arg Asn Leu Ile Ser Ala Arg Leu Ala Ala Asp Val Met Gly 
        195                 200                 205             

Val Pro Thr Ile Ile Val Ala Arg Thr Asp Ala Asp Ala Ala Asp Leu 
    210                 215                 220                 

Ile Thr Ser Asp Ile Asp Pro Val Asp Lys Ala Phe Ile Thr Gly Glu 
225                 230                 235                 240 

Arg Thr Pro Glu Gly Phe Tyr Arg Thr Lys Ala Gly Leu Asp Gln Ala 
                245                 250                 255     

Ile Ala Arg Gly Leu Ala Tyr Ala Pro Tyr Ala Asp Leu Val Trp Cys 
            260                 265                 270         

Glu Thr Ser Glu Pro Asn Leu Glu Asp Ala Lys Arg Phe Ala Asp Ala 
        275                 280                 285             

Ile His Lys Glu His Pro Gly Lys Leu Leu Ala Tyr Asn Cys Ser Pro 
    290                 295                 300                 

Ser Phe Asn Trp Lys Gln Lys Leu Asp Glu Lys Thr Ile Ala Ser Phe 
305                 310                 315                 320 

Gln Lys Glu Ile Ala Ser Tyr Gly Tyr Lys Phe Gln Phe Val Thr Leu 
                325                 330                 335     

Ala Gly Phe His Ser Leu Asn Tyr Gly Met Phe Glu Leu Ala Arg Gly 
            340                 345                 350         

Tyr Lys Glu Arg Gly Met Ala Ala Tyr Ser Glu Leu Gln Gln Ala Glu 
        355                 360                 365             

Phe Ala Ala Glu Lys His Gly Tyr Ser Ala Thr Arg His Gln Arg Glu 
    370                 375                 380                 

Val Gly Thr Gly Tyr Phe Asp Glu Val Ala Gln Val Ile 
385                 390                 395         

<210>   1419
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1412

<400>   1419
Met Thr Tyr Phe Lys Thr Ala Ala Glu Leu Glu Gln His Trp Lys Thr 
                5                   10                  15      

Asp Pro Arg Trp Lys Gly Val Glu Arg Ala Tyr Thr Ala Glu Asp Val 
            20                  25                  30          

Ile Arg Leu Arg Gly Ser Val His Ile Glu His Thr Leu Ala Gln Met 
        35                  40                  45              

Gly Ala Glu Lys Leu Trp Lys Gly Leu His Glu Asp Gly Phe Ile Arg 
    50                  55                  60                  

Ala Leu Gly Ala Leu Thr Gly Asn Gln Ala Val Gln Gln Val Lys Ala 
65                  70                  75                  80  

Gly Leu Lys Ala Ile Tyr Val Ser Gly Trp Gln Val Ala Ala Asp Ala 
                85                  90                  95      

Asn Leu Ala Glu His Met Tyr Pro Asp Gln Ser Leu Tyr Pro Ser Asn 
            100                 105                 110         

Ser Val Pro Ser Leu Val Arg Arg Ile Asn Asn Ala Leu Leu Arg Ala 
        115                 120                 125             

Asp Gln Ile Gln Thr Ala Glu Gly Lys Gly Asp Ile Asp Trp Met Val 
    130                 135                 140                 

Pro Ile Val Ala Asp Ala Glu Ala Gly Phe Gly Gly Pro Leu Asn Val 
145                 150                 155                 160 

Phe Glu Leu Met Lys Met Met Ile Glu Ala Gly Ala Ala Gly Val His 
                165                 170                 175     

Phe Glu Asp Gln Leu Ser Ser Glu Lys Lys Cys Gly His Met Gly Gly 
            180                 185                 190         

Lys Val Leu Ile Pro Thr Ser His Ala Val Arg Asn Leu Thr Ala Ala 
        195                 200                 205             

Arg Leu Ala Ala Asp Val Leu Gly Val Pro Thr Val Ile Val Ala Arg 
    210                 215                 220                 

Thr Asp Ala Asn Gly Ala Phe Leu Ile Thr Ser Asp Val Asp Asp Arg 
225                 230                 235                 240 

Asp Ala Arg Phe Ile Thr Gly Glu Arg Thr Pro Glu Gly Phe Tyr Arg 
                245                 250                 255     

Phe Arg Gly Gly Leu Glu Ala Ala Ile Ala Arg Gly Leu Ala Tyr Ala 
            260                 265                 270         

Pro Tyr Ala Asp Met Ile Trp Cys Glu Thr Ser Glu Pro Asn Ile Glu 
        275                 280                 285             

Glu Ala Lys Arg Phe Ala Glu Ala Ile Lys Ala Glu Phe Pro Asp Lys 
    290                 295                 300                 

Leu Leu Ala Tyr Asn Cys Ser Pro Ser Phe Asn Trp Arg Lys Lys Leu 
305                 310                 315                 320 

Asp Pro Lys Thr Ile Glu Glu Phe Gln Glu Ile Ile Ala Ser Phe Gly 
                325                 330                 335     

Tyr Lys Phe Gln Phe Val Thr Leu Ala Gly Phe His Ala Leu Asn Tyr 
            340                 345                 350         

Ser Met Phe Glu Leu Ala Tyr Gly Tyr Asn Gln Arg Gly Met Gly Ala 
        355                 360                 365             

Tyr Ser Asp Leu Gln Gln Gln Glu Phe Ala Ala Glu Ala Arg Gly Tyr 
    370                 375                 380                 

Thr Ala Thr Arg His Gln Arg Glu Val Gly Thr Gly Tyr Phe Asp Glu 
385                 390                 395                 400 

Val Ala Gln Val Val Ser Gly Gly Leu Ser Ser Thr Thr Ala Leu Thr 
                405                 410                 415     

Gly Ser Thr Glu Glu Glu Gln Phe Val Glu Ala 
            420                 425         

<210>   1420
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1412

<400>   1420
Met Thr Tyr Phe Lys Thr Ala Ala Glu Leu Glu Gln His Trp Lys Thr 
                5                   10                  15      

Asp Pro Arg Trp Lys Gly Val Glu Arg Ala Tyr Thr Ala Glu Asp Val 
            20                  25                  30          

Ile Arg Leu Arg Gly Ser Val His Ile Glu His Thr Leu Ala Gln Met 
        35                  40                  45              

Gly Ala Glu Lys Leu Trp Arg Gly Leu His Glu Asp Gly Phe Ile Arg 
    50                  55                  60                  

Ala Leu Gly Ala Leu Thr Gly Asn Gln Ala Val Gln Gln Val Lys Ala 
65                  70                  75                  80  

Gly Leu Lys Ala Ile Tyr Val Ser Gly Trp Gln Val Ala Ala Asp Ala 
                85                  90                  95      

Asn Leu Ala Glu His Met Tyr Pro Asp Gln Ser Leu Tyr Pro Ser Asn 
            100                 105                 110         

Ser Val Pro Ser Leu Val Arg Arg Ile Asn Asn Ala Leu Leu Arg Ala 
        115                 120                 125             

Asp Gln Ile Gln Thr Ala Glu Gly Lys Gly Asp Ile Asp Trp Met Val 
    130                 135                 140                 

Pro Ile Val Ala Asp Ala Glu Ala Gly Phe Gly Gly Pro Leu Asn Val 
145                 150                 155                 160 

Phe Glu Leu Met Lys Met Met Ile Glu Ala Gly Ala Ala Gly Val His 
                165                 170                 175     

Phe Glu Asp Gln Leu Ser Ser Glu Lys Lys Cys Gly His Met Gly Gly 
            180                 185                 190         

Lys Val Leu Ile Pro Thr Ser His Ala Val Arg Asn Leu Thr Ala Ala 
        195                 200                 205             

Arg Leu Ala Ala Asp Val Leu Gly Val Pro Thr Val Ile Val Ala Arg 
    210                 215                 220                 

Thr Asp Ala Asn Gly Ala Phe Leu Ile Thr Ser Asp Val Asp Asp Arg 
225                 230                 235                 240 

Asp Ala Arg Phe Ile Thr Gly Glu Arg Thr Pro Glu Gly Phe Tyr Arg 
                245                 250                 255     

Phe Arg Gly Gly Leu Glu Ala Ala Ile Ala Arg Gly Leu Ala Tyr Ala 
            260                 265                 270         

Pro Tyr Ala Asp Met Ile Trp Cys Glu Thr Ser Glu Pro Asn Ile Glu 
        275                 280                 285             

Glu Ala Lys Arg Phe Ala Glu Ala Ile Lys Ala Glu Phe Pro Asp Lys 
    290                 295                 300                 

Leu Leu Ala Tyr Asn Cys Ser Pro Ser Phe Asn Trp Arg Lys Lys Leu 
305                 310                 315                 320 

Asp Pro Lys Thr Ile Asp Glu Phe Gln Glu Ile Ile Ala Ser Phe Gly 
                325                 330                 335     

Tyr Lys Phe Gln Phe Val Thr Leu Ala Gly Phe His Ala Leu Asn Tyr 
            340                 345                 350         

Ser Met Phe Glu Leu Ala Tyr Gly Tyr Asn Gln Arg Gly Met Gly Ala 
        355                 360                 365             

Tyr Ser Asp Leu Gln Gln Gln Glu Phe Ala Ala Glu Ala Arg Gly Tyr 
    370                 375                 380                 

Thr Ala Thr Arg His Gln Arg Glu Val Gly Thr Gly Tyr Phe Asp Glu 
385                 390                 395                 400 

Val Ala Gln Val Val Ser Gly Gly Leu Ser Ser Thr Thr Ala Leu Thr 
                405                 410                 415     

Gly Ser Thr Glu Glu Glu Gln Phe Val Glu Ala 
            420                 425         

<210>   1421
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1412

<400>   1421
Met Thr Tyr Phe Lys Thr Ala Ala Glu Leu Glu Gln His Trp Lys Thr 
                5                   10                  15      

Asp Pro Arg Trp Lys Gly Val Glu Arg Ala Tyr Thr Ala Glu Asp Val 
            20                  25                  30          

Ile Arg Leu Arg Gly Ser Val His Ile Glu His Thr Leu Ala Gln Met 
        35                  40                  45              

Gly Ala Glu Lys Leu Trp Arg Gly Leu His Glu Asp Gly Phe Ile Lys 
    50                  55                  60                  

Ala Leu Gly Ala Leu Thr Gly Asn Gln Ala Val Gln Gln Val Lys Ala 
65                  70                  75                  80  

Gly Leu Lys Ala Ile Tyr Val Ser Gly Trp Gln Val Ala Ala Asp Ala 
                85                  90                  95      

Asn Leu Ala Glu His Met Tyr Pro Asp Gln Ser Leu Tyr Pro Ser Asn 
            100                 105                 110         

Ser Val Pro Ser Leu Val Arg Arg Ile Asn Asn Ala Leu Leu Arg Ala 
        115                 120                 125             

Asp Gln Ile Gln Thr Ala Glu Gly Lys Gly Asp Ile Asp Trp Met Val 
    130                 135                 140                 

Pro Ile Val Ala Asp Ala Glu Ala Gly Phe Gly Gly Pro Leu Asn Val 
145                 150                 155                 160 

Phe Glu Leu Met Lys Met Met Ile Glu Ala Gly Ala Ala Gly Val His 
                165                 170                 175     

Phe Glu Asp Gln Leu Ser Ser Glu Lys Lys Cys Gly His Met Gly Gly 
            180                 185                 190         

Lys Val Leu Ile Pro Thr Ser His Ala Val Arg Asn Leu Thr Ala Ala 
        195                 200                 205             

Arg Leu Ala Ala Asp Val Leu Gly Val Pro Thr Val Ile Val Ala Arg 
    210                 215                 220                 

Thr Asp Ala Asn Gly Ala Phe Leu Ile Thr Ser Asp Val Asp Asp Arg 
225                 230                 235                 240 

Asp Ala Arg Phe Ile Thr Gly Glu Arg Thr Pro Glu Gly Phe Tyr Arg 
                245                 250                 255     

Phe Arg Gly Gly Leu Glu Ala Ala Ile Ala Arg Gly Leu Ala Tyr Ala 
            260                 265                 270         

Pro Tyr Ala Asp Met Ile Trp Cys Glu Thr Ser Glu Pro Asn Ile Glu 
        275                 280                 285             

Glu Ala Lys Arg Phe Ala Glu Ala Ile Lys Ala Glu Phe Pro Asp Lys 
    290                 295                 300                 

Leu Leu Ala Tyr Asn Cys Ser Pro Ser Phe Asn Trp Arg Lys Lys Leu 
305                 310                 315                 320 

Asp Pro Lys Thr Ile Glu Glu Phe Gln Glu Ile Ile Ala Ser Phe Gly 
                325                 330                 335     

Tyr Lys Phe Gln Phe Val Thr Leu Ala Gly Phe His Ala Leu Asn Tyr 
            340                 345                 350         

Ser Met Phe Glu Leu Ala Tyr Gly Tyr Asn Gln Arg Gly Met Gly Ala 
        355                 360                 365             

Tyr Ser Asp Leu Gln Gln Gln Glu Phe Ala Ala Glu Ala Arg Gly Tyr 
    370                 375                 380                 

Thr Ala Thr Arg His Gln Arg Glu Val Gly Thr Gly Tyr Phe Asp Glu 
385                 390                 395                 400 

Val Ala Gln Val Val Ser Gly Gly Leu Ser Ser Thr Thr Ala Leu Thr 
                405                 410                 415     

Gly Ser Thr Glu Glu Glu Gln Phe Val Glu Ala 
            420                 425         

<210>   1422
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1412

<400>   1422
Met Thr Tyr Phe Lys Thr Ala Ala Glu Leu Glu Gln His Trp Lys Thr 
                5                   10                  15      

Asp Pro Arg Trp Lys Gly Val Glu Arg Ala Tyr Thr Ala Glu Asp Val 
            20                  25                  30          

Ile Arg Leu Arg Gly Ser Val His Ile Glu His Thr Leu Ala Gln Met 
        35                  40                  45              

Gly Ala Glu Lys Leu Trp Arg Gly Leu His Glu Asp Gly Phe Ile Arg 
    50                  55                  60                  

Ala Leu Gly Ala Leu Thr Gly Asn Gln Ala Val Gln Gln Val Lys Ala 
65                  70                  75                  80  

Gly Leu Lys Ala Ile Tyr Val Ser Gly Trp Gln Val Ala Ala Asp Ala 
                85                  90                  95      

Asn Leu Ala Glu His Met Tyr Pro Asp Gln Ser Leu Tyr Pro Ser Asn 
            100                 105                 110         

Ser Val Pro Ser Leu Val Arg Arg Ile Asn Asn Ala Leu Leu Arg Ala 
        115                 120                 125             

Asp Gln Ile Gln Thr Ala Glu Gly Lys Gly Asp Ile Asp Trp Met Val 
    130                 135                 140                 

Pro Ile Val Ala Asp Ala Glu Ala Gly Phe Gly Gly Pro Leu Asn Val 
145                 150                 155                 160 

Phe Glu Leu Met Lys Met Met Ile Glu Ala Gly Ala Ala Gly Val His 
                165                 170                 175     

Phe Glu Asp Gln Leu Ser Ser Glu Lys Lys Cys Gly His Met Gly Gly 
            180                 185                 190         

Lys Val Leu Ile Pro Thr Ser His Ala Val Arg Asn Leu Thr Ala Ala 
        195                 200                 205             

Arg Leu Ala Ala Asp Val Leu Gly Val Pro Thr Val Ile Val Ala Arg 
    210                 215                 220                 

Thr Asp Ala Asn Gly Ala Phe Leu Ile Thr Ser Asp Val Asp Asp Arg 
225                 230                 235                 240 

Asp Ala Arg Phe Ile Thr Gly Glu Arg Thr Pro Glu Gly Phe Tyr Arg 
                245                 250                 255     

Phe Arg Gly Gly Leu Glu Ala Ala Ile Ala Arg Gly Leu Ala Tyr Ala 
            260                 265                 270         

Pro Tyr Ala Asp Met Ile Trp Cys Glu Thr Ser Glu Pro Asn Ile Glu 
        275                 280                 285             

Glu Ala Lys Arg Phe Ala Glu Ala Ile Lys Ala Glu Phe Pro Asp Lys 
    290                 295                 300                 

Leu Leu Ala Tyr Asn Cys Ser Pro Ser Phe Asn Trp Arg Lys Lys Leu 
305                 310                 315                 320 

Asp Pro Lys Thr Ile Glu Glu Phe Gln Glu Ile Ile Ala Ser Phe Gly 
                325                 330                 335     

Tyr Lys Phe Gln Phe Val Thr Leu Ala Gly Phe His Ala Leu Asn Tyr 
            340                 345                 350         

Ser Met Phe Glu Leu Ala Tyr Gly Tyr Asn Gln Arg Gly Met Gly Ala 
        355                 360                 365             

Tyr Ser Asp Leu Gln Gln Gln Glu Phe Ala Ala Glu Ala Arg Gly Tyr 
    370                 375                 380                 

Thr Ala Thr Arg His Gln Arg Glu Val Gly Thr Gly Tyr Phe Asp Glu 
385                 390                 395                 400 

Val Ala Gln Val Val Ser Gly Gly Ile Ser Ser Thr Thr Ala Leu Thr 
                405                 410                 415     

Gly Ser Thr Glu Glu Glu Gln Phe Val Glu Ala 
            420                 425         

<210>   1423
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1412

<400>   1423
Met Thr Tyr Phe Lys Thr Ala Ala Glu Leu Glu Gln His Trp Lys Thr 
                5                   10                  15      

Asp Pro Arg Trp Lys Gly Val Glu Arg Ala Tyr Thr Ala Glu Asp Val 
            20                  25                  30          

Ile Arg Leu Arg Gly Ser Val His Ile Glu His Thr Leu Ala Gln Met 
        35                  40                  45              

Gly Ala Glu Lys Leu Trp Arg Gly Leu His Glu Asp Gly Phe Ile Arg 
    50                  55                  60                  

Ala Leu Gly Ala Leu Thr Gly Asn Gln Ala Val Gln Gln Val Lys Ala 
65                  70                  75                  80  

Gly Leu Lys Ala Ile Tyr Val Ser Gly Trp Gln Val Ala Ala Asp Ala 
                85                  90                  95      

Asn Leu Ala Glu His Met Tyr Pro Asp Gln Ser Leu Tyr Pro Ser Asn 
            100                 105                 110         

Ser Val Pro Ser Leu Val Arg Arg Ile Asn Asn Ala Leu Leu Arg Ala 
        115                 120                 125             

Asp Gln Ile Gln Thr Ala Glu Gly Lys Gly Asp Ile Asp Trp Met Val 
    130                 135                 140                 

Pro Ile Val Ala Asp Ala Glu Ala Gly Phe Gly Gly Pro Leu Asn Val 
145                 150                 155                 160 

Phe Glu Leu Met Lys Met Met Ile Glu Ala Gly Ala Ala Gly Val His 
                165                 170                 175     

Phe Glu Asp Gln Leu Ser Ser Glu Lys Lys Cys Gly His Met Gly Gly 
            180                 185                 190         

Lys Val Leu Ile Pro Thr Ser His Ala Val Arg Asn Leu Thr Ala Ala 
        195                 200                 205             

Arg Leu Ala Ala Asp Val Leu Gly Val Pro Thr Val Ile Val Ala Arg 
    210                 215                 220                 

Thr Asp Ala Asn Gly Ala Phe Leu Ile Thr Ser Asp Val Asp Glu Arg 
225                 230                 235                 240 

Asp Ala Arg Phe Ile Thr Gly Glu Arg Thr Pro Glu Gly Phe Tyr Arg 
                245                 250                 255     

Phe Arg Gly Gly Leu Glu Ala Ala Ile Ala Arg Gly Leu Ala Tyr Ala 
            260                 265                 270         

Pro Tyr Ala Asp Met Ile Trp Cys Glu Thr Ser Glu Pro Asn Ile Glu 
        275                 280                 285             

Glu Ala Lys Arg Phe Ala Glu Ala Ile Lys Ala Glu Phe Pro Asp Lys 
    290                 295                 300                 

Leu Leu Ala Tyr Asn Cys Ser Pro Ser Phe Asn Trp Arg Lys Lys Leu 
305                 310                 315                 320 

Asp Pro Lys Thr Ile Glu Glu Phe Gln Glu Ile Ile Ala Ser Phe Gly 
                325                 330                 335     

Tyr Lys Phe Gln Phe Val Thr Leu Ala Gly Phe His Ala Leu Asn Tyr 
            340                 345                 350         

Ser Met Phe Glu Leu Ala Tyr Gly Tyr Asn Gln Arg Gly Met Gly Ala 
        355                 360                 365             

Tyr Ser Asp Leu Gln Gln Gln Glu Phe Ala Ala Glu Ala Arg Gly Tyr 
    370                 375                 380                 

Thr Ala Thr Arg His Gln Arg Glu Val Gly Thr Gly Tyr Phe Asp Glu 
385                 390                 395                 400 

Val Ala Gln Val Val Ser Gly Gly Leu Ser Ser Thr Thr Ala Leu Thr 
                405                 410                 415     

Gly Ser Thr Glu Glu Glu Gln Phe Val Glu Ala 
            420                 425         

<210>   1424
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1413

<400>   1424
atgacatact tcaaaacggc ggcggaactg gagcagcatt ggaagacgga tcctcgttgg       60

aaaggcgtcg agcgcgccta tacggccgaa gacgtgattc ggctcagggg atcggtgcac      120

attgaacaca cactcgcgca gatgggcgcg gagaagctgt ggaaaggtct ccatgaagac      180

ggcttcattc gcgcgctcgg tgccctgacc ggcaaccagg ccgtgcaaca ggtgaaagcg      240

gggctgaagg ccatctacgt cagcggctgg caggtggcgg cggacgccaa cctggctgag      300

catatgtacc cggatcagag cctgtatccg tccaacagcg tgccgagcct cgtgcggcgc      360

atcaacaacg cgctgttgcg cgcggatcag attcagaccg cggaaggcaa gggcgacatc      420

gactggatgg tgccgattgt ggccgacgcc gaggcaggct tcggcgggcc gctgaacgtg      480

ttcgaactca tgaagatgat gattgaggcc ggcgccgcgg gcgttcactt cgaagatcag      540

ctgtcatcgg agaagaagtg cggtcacatg ggcggcaagg tgctcatccc cacgtcgcac      600

gcggtgcgga atctgacggc cgcccgtctc gctgccgatg tgctcggcgt gccgacggtc      660

atcgtggcgc gcacagacgc caacggcgcg ttcctcatca cgagcgatgt cgacgatcgc      720

gacgcgcggt tcatcaccgg cgagcgcacg ccggaagggt tctaccggtt ccggggcggg      780

ctggaggccg caattgcccg cggactcgct tatgcgccgt acgcggacat gatctggtgc      840

gagacgtccg agccgaacat cgaggaagcg aagcggtttg cggaggccat caaggccgaa      900

ttcccggata aacttctggc ctacaactgc tcgccctctt tcaactggcg gaagaagctc      960

gatccgaaga ccatcgagga gttccaggag atcatcgcgt cgttcggcta caagttccag     1020

ttcgtgaccc tggcgggctt ccacgccctc aactacagca tgttcgagct cgcgtatggc     1080

tacaaccagc gcggcatggg ggcgtactcg gacctgcagc agcaggagtt cgcggcggag     1140

gcccgtggct acacggcgac acgccatcag cgggaggtgg gcacgggcta cttcgatgaa     1200

gtggcgcagg tggtgtcggg cgggctctcg tccacgacgg cgctcaccgg ctccacggag     1260

gaggagcagt ttgtggaggc gtga                                            1284


<210>   1425
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1413

<400>   1425
atgacatact tcaaaacggc ggcggaactg gagcagcatt ggaagacgga tcctcgttgg       60

aaaggcgtcg agcgcgccta tacggccgaa gacgtgattc ggctcagggg atcggtgcac      120

attgaacaca cactcgcgca gatgggcgcg gagaagctgt ggcggggtct ccatgaagac      180

ggcttcattc gcgcgctcgg tgccctgacc ggcaaccagg ccgtgcaaca ggtgaaagcg      240

gggctgaagg ccatctacgt cagcggctgg caggtggcgg cggacgccaa cctggctgag      300

catatgtacc cggatcagag cctgtatccg tccaacagcg tgccgagcct cgtgcggcgc      360

atcaacaacg cgctgttgcg cgcggatcag attcagaccg cggaaggcaa gggcgacatc      420

gactggatgg tgccgattgt ggccgacgcc gaggcaggct tcggcgggcc gctgaacgtg      480

ttcgaactca tgaagatgat gattgaggcc ggcgccgcgg gcgttcactt cgaagatcag      540

ctgtcatcgg agaagaagtg cggtcacatg ggcggcaagg tgctcatccc cacgtcgcac      600

gcggtgcgga atctgacggc cgcccgtctc gctgccgatg tgctcggcgt gccgacggtc      660

atcgtggcgc gcacagacgc caacggcgcg ttcctcatca cgagcgatgt cgacgatcgc      720

gacgcgcggt tcatcaccgg cgagcgcacg ccggaagggt tctaccggtt ccggggcggg      780

ctggaggccg caattgcccg cggactcgct tatgcgccgt acgcggacat gatctggtgc      840

gagacgtccg agccgaacat cgaggaagcg aagcggtttg cggaggccat caaggccgaa      900

ttcccggata aacttctggc ctacaactgc tcgccctctt tcaactggcg gaagaagctc      960

gatccgaaga ccatcgatga gttccaggag atcatcgcgt cgttcggcta caagttccag     1020

ttcgtgaccc tggcgggctt ccacgccctc aactacagca tgttcgagct cgcgtatggc     1080

tacaaccagc gcggcatggg ggcgtactcg gacctgcagc agcaggagtt cgcggcggag     1140

gcccgtggct acacggcgac acgccatcag cgggaggtgg gcacgggcta cttcgatgaa     1200

gtggcgcagg tggtgtcggg cgggctctcg tccacgacgg cgctcaccgg ctccacggag     1260

gaggagcagt ttgtggaggc gtga                                            1284


<210>   1426
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1413

<400>   1426
atgacatact tcaaaacggc ggcggaactg gagcagcatt ggaagacgga tcctcgttgg       60

aaaggcgtcg agcgcgccta tacggccgaa gacgtgattc ggctcagggg atcggtgcac      120

attgaacaca cactcgcgca gatgggcgcg gagaagctgt ggcggggtct ccatgaagac      180

ggcttcatta aagcgctcgg tgccctgacc ggcaaccagg ccgtgcaaca ggtgaaagcg      240

gggctgaagg ccatctacgt cagcggctgg caggtggcgg cggacgccaa cctggctgag      300

catatgtacc cggatcagag cctgtatccg tccaacagcg tgccgagcct cgtgcggcgc      360

atcaacaacg cgctgttgcg cgcggatcag attcagaccg cggaaggcaa gggcgacatc      420

gactggatgg tgccgattgt ggccgacgcc gaggcaggct tcggcgggcc gctgaacgtg      480

ttcgaactca tgaagatgat gattgaggcc ggcgccgcgg gcgttcactt cgaagatcag      540

ctgtcatcgg agaagaagtg cggtcacatg ggcggcaagg tgctcatccc cacgtcgcac      600

gcggtgcgga atctgacggc cgcccgtctc gctgccgatg tgctcggcgt gccgacggtc      660

atcgtggcgc gcacagacgc caacggcgcg ttcctcatca cgagcgatgt cgacgatcgc      720

gacgcgcggt tcatcaccgg cgagcgcacg ccggaagggt tctaccggtt ccggggcggg      780

ctggaggccg caattgcccg cggactcgct tatgcgccgt acgcggacat gatctggtgc      840

gagacgtccg agccgaacat cgaggaagcg aagcggtttg cggaggccat caaggccgaa      900

ttcccggata aacttctggc ctacaactgc tcgccctctt tcaactggcg gaagaagctc      960

gatccgaaga ccatcgagga gttccaggag atcatcgcgt cgttcggcta caagttccag     1020

ttcgtgaccc tggcgggctt ccacgccctc aactacagca tgttcgagct cgcgtatggc     1080

tacaaccagc gcggcatggg ggcgtactcg gacctgcagc agcaggagtt cgcggcggag     1140

gcccgtggct acacggcgac acgccatcag cgggaggtgg gcacgggcta cttcgatgaa     1200

gtggcgcagg tggtgtcggg cgggctctcg tccacgacgg cgctcaccgg ctccacggag     1260

gaggagcagt ttgtggaggc gtga                                            1284


<210>   1427
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1413

<400>   1427
atgacatact tcaaaacggc ggcggaactg gagcagcatt ggaagacgga tcctcgttgg       60

aaaggcgtcg agcgcgccta tacggccgaa gacgtgattc ggctcagggg atcggtgcac      120

attgaacaca cactcgcgca gatgggcgcg gagaagctgt ggcggggtct ccatgaagac      180

ggcttcattc gcgcgctcgg tgccctgacc ggcaaccagg ccgtgcaaca ggtgaaagcg      240

gggctgaagg ccatctacgt cagcggctgg caggtggcgg cggacgccaa cctggctgag      300

catatgtacc cggatcagag cctgtatccg tccaacagcg tgccgagcct cgtgcggcgc      360

atcaacaacg cgctgttgcg cgcggatcag attcagaccg cggaaggcaa gggcgacatc      420

gactggatgg tgccgattgt ggccgacgcc gaggcaggct tcggcgggcc gctgaacgtg      480

ttcgaactca tgaagatgat gattgaggcc ggcgccgcgg gcgttcactt cgaagatcag      540

ctgtcatcgg agaagaagtg cggtcacatg ggcggcaagg tgctcatccc cacgtcgcac      600

gcggtgcgga atctgacggc cgcccgtctc gctgccgatg tgctcggcgt gccgacggtc      660

atcgtggcgc gcacagacgc caacggcgcg ttcctcatca cgagcgatgt cgacgatcgc      720

gacgcgcggt tcatcaccgg cgagcgcacg ccggaagggt tctaccggtt ccggggcggg      780

ctggaggccg caattgcccg cggactcgct tatgcgccgt acgcggacat gatctggtgc      840

gagacgtccg agccgaacat cgaggaagcg aagcggtttg cggaggccat caaggccgaa      900

ttcccggata aacttctggc ctacaactgc tcgccctctt tcaactggcg gaagaagctc      960

gatccgaaga ccatcgagga gttccaggag atcatcgcgt cgttcggcta caagttccag     1020

ttcgtgaccc tggcgggctt ccacgccctc aactacagca tgttcgagct cgcgtatggc     1080

tacaaccagc gcggcatggg ggcgtactcg gacctgcagc agcaggagtt cgcggcggag     1140

gcccgtggct acacggcgac acgccatcag cgggaggtgg gcacgggcta cttcgatgaa     1200

gtggcgcagg tggtgtcggg cgggatttcg tccacgacgg cgctcaccgg ctccacggag     1260

gaggagcagt ttgtggaggc gtga                                            1284


<210>   1428
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1413

<400>   1428
atgacatact tcaaaacggc ggcggaactg gagcagcatt ggaagacgga tcctcgttgg       60

aaaggcgtcg agcgcgccta tacggccgaa gacgtgattc ggctcagggg atcggtgcac      120

attgaacaca cactcgcgca gatgggcgcg gagaagctgt ggcggggtct ccatgaagac      180

ggcttcattc gcgcgctcgg tgccctgacc ggcaaccagg ccgtgcaaca ggtgaaagcg      240

gggctgaagg ccatctacgt cagcggctgg caggtggcgg cggacgccaa cctggctgag      300

catatgtacc cggatcagag cctgtatccg tccaacagcg tgccgagcct cgtgcggcgc      360

atcaacaacg cgctgttgcg cgcggatcag attcagaccg cggaaggcaa gggcgacatc      420

gactggatgg tgccgattgt ggccgacgcc gaggcaggct tcggcgggcc gctgaacgtg      480

ttcgaactca tgaagatgat gattgaggcc ggcgccgcgg gcgttcactt cgaagatcag      540

ctgtcatcgg agaagaagtg cggtcacatg ggcggcaagg tgctcatccc cacgtcgcac      600

gcggtgcgga atctgacggc cgcccgtctc gctgccgatg tgctcggcgt gccgacggtc      660

atcgtggcgc gcacagacgc caacggcgcg ttcctcatca cgagcgatgt cgacgaacgc      720

gacgcgcggt tcatcaccgg cgagcgcacg ccggaagggt tctaccggtt ccggggcggg      780

ctggaggccg caattgcccg cggactcgct tatgcgccgt acgcggacat gatctggtgc      840

gagacgtccg agccgaacat cgaggaagcg aagcggtttg cggaggccat caaggccgaa      900

ttcccggata aacttctggc ctacaactgc tcgccctctt tcaactggcg gaagaagctc      960

gatccgaaga ccatcgagga gttccaggag atcatcgcgt cgttcggcta caagttccag     1020

ttcgtgaccc tggcgggctt ccacgccctc aactacagca tgttcgagct cgcgtatggc     1080

tacaaccagc gcggcatggg ggcgtactcg gacctgcagc agcaggagtt cgcggcggag     1140

gcccgtggct acacggcgac acgccatcag cgggaggtgg gcacgggcta cttcgatgaa     1200

gtggcgcagg tggtgtcggg cgggctctcg tccacgacgg cgctcaccgg ctccacggag     1260

gaggagcagt ttgtggaggc gtga                                            1284


<210>   1429
<211>   566
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1429
Met Asp Met Asn Asn Val Asn Lys Tyr Thr Arg Gln Tyr Phe Leu Pro 
                5                   10                  15      

Pro Glu Pro Cys Phe Asp Trp Val His Lys Asp His Val Asp Arg Pro 
            20                  25                  30          

Pro Ile Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile 
        35                  40                  45              

Val Pro Met Asn Leu Glu Glu Lys Leu Ala Tyr Phe Gln Leu Leu Val 
    50                  55                  60                  

Glu Ile Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Asp 
65                  70                  75                  80  

Thr Glu Phe Glu Phe Val Arg Thr Leu Ile Glu Arg Asp Leu Val Pro 
                85                  90                  95      

Ser Asp Val Thr Ile Gln Val Leu Thr Gln Ser Arg Asp His Ile Ile 
            100                 105                 110         

Glu Arg Thr Phe Glu Ala Ile Arg Gly Ala Lys Arg Ala Ile Val His 
        115                 120                 125             

Leu Tyr Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Arg Ala 
    130                 135                 140                 

Asp Lys Asp Glu Ile Val Asn Ile Ala Val Thr Gly Ala Glu Gln Ile 
145                 150                 155                 160 

Arg Asp Leu Ala Arg Thr Thr Pro Gly Asn Phe Phe Phe Gln Tyr Ser 
                165                 170                 175     

Pro Glu Ser Phe Thr Gly Thr Glu Leu Asp Phe Ala Leu Glu Ile Cys 
            180                 185                 190         

Asn Ala Val Leu Asp Val Trp Lys Pro Thr Pro Asp Arg Lys Val Ile 
        195                 200                 205             

Ile Asn Leu Pro Ala Thr Val Glu Leu Ser Met Pro His Val Tyr Ala 
    210                 215                 220                 

Ser Gln Ile Glu Tyr Met Gly Lys Arg Leu Ala Arg Arg Asp Ala Ile 
225                 230                 235                 240 

Val Leu Ser Val His Pro His Asn Asp Arg Gly Thr Gly Val Ala Ala 
                245                 250                 255     

Ala Glu Leu Ala Met Leu Ala Gly Ala Glu Arg Leu Glu Gly Thr Leu 
            260                 265                 270         

Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Val Thr Leu Ala 
        275                 280                 285             

Leu Asn Leu Tyr Ser His Gly Ile Asp Pro Gly Leu Asp Phe Ser Asn 
    290                 295                 300                 

Leu Pro Ala Ile Gln Ala Arg Val Glu Ala Leu Thr Lys Met Gln Val 
305                 310                 315                 320 

Ser Arg Arg His Pro Tyr Ala Gly Glu Leu Val Phe Thr Ala Phe Ser 
                325                 330                 335     

Gly Ser His Gln Asp Ala Ile Ala Lys Gly Met Lys Trp Arg Glu Glu 
            340                 345                 350         

Lys Ser Pro Glu His Trp Thr Val Pro Tyr Leu Pro Ile Asp Pro Lys 
        355                 360                 365             

Asp Ile Gly Arg Glu Tyr Glu Gly Asp Ile Ile Arg Ile Asn Ser Gln 
    370                 375                 380                 

Ser Gly Lys Gly Gly Ile Gly Tyr Val Leu Glu Gln Ser His Gly Phe 
385                 390                 395                 400 

Asp Leu Pro Pro Lys Met Arg Glu Gln Leu Gly Tyr Ala Val Lys Arg 
                405                 410                 415     

Val Ser Asp Arg Glu Gln Lys Glu Leu Ser Ala Asp Glu Ile Ala Glu 
            420                 425                 430         

Ile Phe Met Arg Glu Phe Val Asn Leu Gly Gln Pro Leu Asp Leu Val 
        435                 440                 445             

Glu Leu Thr Gly Thr Asp Ala Arg Gly Ser His Arg Val Arg Ala Thr 
    450                 455                 460                 

Val Val Trp Gln Gly Glu Thr Val Glu Ile Glu Gly Ala Gly Asn Gly 
465                 470                 475                 480 

Arg Leu Asp Ala Leu Cys His Ala Leu Glu Glu Gly Leu Gly Ile Arg 
                485                 490                 495     

Val Ala Asn Leu Thr Tyr Lys Glu His Ala Leu Glu Val Gly Ser Gly 
            500                 505                 510         

Ser Arg Ala Val Ala Tyr Ile Ser Val Asp Asp Glu Glu Gly Asn Thr 
        515                 520                 525             

His Phe Gly Cys Gly Val Asp Thr Asp Ile Met Glu Ala Ser Ala Lys 
    530                 535                 540                 

Ala Leu Val Ser Ala Val Asn Arg Met Leu Ala His Arg Ala Glu Met 
545                 550                 555                 560 

Ala Val Pro Val Ser Lys 
                565     

<210>   1430
<211>   1701
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1430
atggacatga acaacgtgaa caagtacacc cgccagtatt ttctgccgcc tgaaccctgc       60

ttcgactggg ttcacaagga ccatgtggac cgaccgccga tctggtgcag cgtcgacctg      120

cgcgacggaa atcaggcgct catcgttccg atgaatctcg aggagaagct tgcgtacttt      180

caactgctcg tcgagatcgg cttcaaggag atcgaggtcg gtttcccggc cgcatcggac      240

acggaattcg agttcgtccg gacgctcatc gagcgcgatc tcgtcccgag cgatgtgacc      300

atccaggtcc tcacgcaatc gcgcgatcac atcatcgaac gcacttttga agccattcgc      360

ggggccaagc gggccatcgt ccatctctac aactccacgt ccgtggcgca gcgcgagcag      420

gtgttccgcg cggacaagga cgagatcgtg aacattgccg tgaccggcgc cgaacagatc      480

cgcgatctcg cccgcaccac gcccggcaac ttcttcttcc aatattcacc ggagagcttc      540

acgggtacgg agctcgactt cgcgctcgag atctgcaacg cggtgctcga cgtgtggaaa      600

cccacgccgg atcgcaaggt catcatcaac ctgccggcga ccgtcgagct ttcgatgccg      660

cacgtgtacg cgagccagat cgagtacatg ggcaagcgcc tggctcgccg cgatgccatc      720

gtgctgtccg tgcatccgca caacgatcgc ggcacgggtg tcgcggcggc tgaactcgcc      780

atgctcgcgg gcgcggagcg gctggagggc acgctgtttg ggaacgggga gcgcacgggc      840

aacgtggaca tcgtcacgct cgcgctgaac ctgtactcgc acggcatcga tccggggctc      900

gacttctcca acctcccggc catccaggcc cgtgttgagg ctctcaccaa gatgcaggtg      960

agcaggcgtc acccgtacgc gggggaactc gtcttcacgg cgttttcggg atcgcatcaa     1020

gacgcgatcg cgaagggcat gaagtggcgc gaggagaagt cgcctgagca ttggacggtc     1080

ccgtatctgc ccatcgaccc gaaggatatt ggccgcgaat acgaggggga tatcatccgc     1140

atcaacagcc agtctggcaa gggcggcatc ggctacgtgt tggagcaatc gcacggcttc     1200

gatctgcctc caaagatgcg cgagcagctg gggtatgcgg tcaagcgggt gtcggatcgc     1260

gagcagaagg agctgtcggc ggacgagatc gccgagatct tcatgcgcga gtttgtgaac     1320

cttgggcagc cgctcgatct cgtcgaactg acgggcacgg atgcgagagg gtcgcaccgc     1380

gtgcgcgcca cggtggtctg gcagggcgag accgtcgaga tcgaaggggc cggcaatggg     1440

cggttggacg cgctgtgcca tgcgctggag gaggggctcg ggatccgggt cgcgaatctc     1500

acgtacaagg aacatgcgct ggaagtaggg tcgggatcgc gagcggtggc ttacatcagc     1560

gtcgacgacg aagaagggaa tacccacttc gggtgcggcg tggataccga cattatggag     1620

gcgtcggcga aggcgctggt gagcgcggtc aatcgaatgc tggcgcacag ggcggagatg     1680

gcggtgcccg tgagcaaatg a                                               1701


<210>   1431
<211>   549
<212>   PRT
<213>   Clostridium leptum DSM 753

<400>   1431
Met Arg Asn Val Glu Lys Tyr Thr Thr Gln Tyr Phe Met Pro Pro Val 
                5                   10                  15      

Pro Cys Tyr Asp Trp Thr Lys Lys Glu Tyr Val Glu Lys Ala Pro Ile 
            20                  25                  30          

Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile Val Pro 
        35                  40                  45              

Met Ser Leu Glu Glu Lys Leu Glu Phe Phe Lys Phe Leu Val Glu Ile 
    50                  55                  60                  

Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Glu Thr Glu 
65                  70                  75                  80  

Tyr Glu Phe Leu Arg Thr Leu Ile Glu Arg Asp Met Ile Pro Glu Asp 
                85                  90                  95      

Val Thr Val Gln Val Leu Thr Gln Ala Arg Glu His Ile Ile Arg Arg 
            100                 105                 110         

Thr Phe Glu Ala Leu Glu Gly Cys Pro Arg Ala Ile Val His Leu Tyr 
        115                 120                 125             

Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Arg Lys Ser Lys 
    130                 135                 140                 

Glu Glu Ile Ile Arg Ile Ala Val Asp Gly Ala Lys Leu Leu Gln Lys 
145                 150                 155                 160 

Ile Ser Ser Glu Met Gly Ser Asp Phe Arg Phe Glu Tyr Ser Pro Glu 
                165                 170                 175     

Ser Phe Thr Gly Thr Glu Met Glu Phe Ala Arg Asp Ile Cys Asn Ala 
            180                 185                 190         

Val Leu Asp Val Trp Lys Pro Thr Pro Glu Lys Lys Val Ile Ile Asn 
        195                 200                 205             

Leu Pro Val Thr Val Glu His Ser Met Pro His Val Tyr Ala Cys Gln 
    210                 215                 220                 

Val Glu Tyr Met Cys Lys His Leu Asp Tyr Arg Asp Ser Val Val Val 
225                 230                 235                 240 

Ser Leu His Pro His Asn Asp Arg Gly Cys Gly Val Ala Asp Cys Glu 
                245                 250                 255     

Leu Gly Leu Leu Ala Gly Ala Asp Arg Ile Glu Gly Thr Leu Phe Gly 
            260                 265                 270         

Asn Gly Glu Arg Thr Gly Asn Ala Asp Ile Val Thr Leu Ala Leu Asn 
        275                 280                 285             

Met Phe Ser Gln Gly Val Asp Pro Lys Leu Asn Phe Glu Asp Met Pro 
    290                 295                 300                 

Ser Thr Val Ala Leu Tyr Glu Lys Val Thr Gly Met His Val Tyr Asp 
305                 310                 315                 320 

Arg Gln Pro Tyr Gly Gly Lys Leu Val Phe Ala Ala Phe Ser Gly Ser 
                325                 330                 335     

His Gln Asp Ala Ile Ala Lys Gly Met Lys Trp Arg Glu Glu Lys Glu 
            340                 345                 350         

Cys Asp His Trp Thr Val Pro Tyr Leu Cys Ile Asp Pro Lys Asp Ile 
        355                 360                 365             

Gly Arg Glu Tyr Glu Gly Asp Val Ile Arg Ile Asn Ser Gln Ser Gly 
    370                 375                 380                 

Lys Gly Gly Ile Gly Tyr Leu Leu Glu Gln Lys Tyr Gly Phe Val Leu 
385                 390                 395                 400 

Pro Pro Lys Met Arg Glu Asp Phe Gly Tyr Ala Val Lys Asn Val Ser 
                405                 410                 415     

Asp His Gln His Lys Glu Leu Gln Pro Glu Glu Val Tyr Glu Ile Phe 
            420                 425                 430         

Arg Arg Glu Tyr Leu Asn Ile Asn Asp Lys Ile Ser Leu Val Asp Phe 
        435                 440                 445             

His Phe Val Arg Asn Asp Cys Ile His Ala Ala Val Thr Val Lys Ile 
    450                 455                 460                 

Gly Gly Val Glu Lys Glu Ile Lys Gly Asp Gly Asn Gly Arg Leu Asp 
465                 470                 475                 480 

Ala Val Ser Asn Ala Ile Lys Glu Asn Leu Gly Ile Gln Tyr Gln Asp 
                485                 490                 495     

Leu Thr Tyr Thr Glu His Ala Leu Glu Gln Gly Ser Lys Ser Arg Ala 
            500                 505                 510         

Ala Ala Tyr Val Gly Ile Thr Gly Lys Asp Gly Arg Ile Thr Trp Gly 
        515                 520                 525             

Val Gly Val Asp Ser Asp Ile Ile Thr Ala Ser Val Lys Ala Leu Phe 
    530                 535                 540                 

Ser Ala Ile Asn Arg 
545                 

<210>   1432
<211>   555
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   1432
Met Lys Asn Val Asp Asn Tyr Arg Arg Gly Tyr Phe Met Pro Pro Val 
                5                   10                  15      

Lys Ser Leu Lys Trp Ala Glu Lys Glu Tyr Ile Thr Thr Pro Pro Thr 
            20                  25                  30          

Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Val Val Pro 
        35                  40                  45              

Met Ser Leu Glu Glu Lys Leu Glu Tyr Tyr His Met Leu Leu Lys Ile 
    50                  55                  60                  

Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Glu Thr Glu 
65                  70                  75                  80  

Tyr Ala Phe Leu Arg Thr Leu Ile Glu Gln Asn Leu Ile Pro Glu Asp 
                85                  90                  95      

Val Thr Ile Gln Val Leu Thr Gln Ser Arg Asp His Ile Ile Glu Lys 
            100                 105                 110         

Thr Phe Lys Ala Leu Val Gly Val Lys Lys Ala Val Val His Leu Tyr 
        115                 120                 125             

Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Lys Met Ser Arg 
    130                 135                 140                 

Glu Glu Ile Val Glu Ile Ala Val Ser Gly Ala Arg Leu Leu Lys Lys 
145                 150                 155                 160 

Tyr Ala Ala Glu Thr Glu Gly Asn Phe Gln Phe Glu Tyr Ser Pro Glu 
                165                 170                 175     

Ser Phe Thr Gly Thr Glu Met Glu Phe Ala Leu Glu Ile Cys Asn Gln 
            180                 185                 190         

Val Leu Asp Val Phe Glu Pro Thr Pro Glu Asn Lys Val Ile Ile Asn 
        195                 200                 205             

Leu Pro Ala Thr Val Ser Leu Ser Met Pro His Val Tyr Ala Ser Gln 
    210                 215                 220                 

Ile Glu Tyr Met Ser Glu His Leu Lys Tyr Arg Asp Asn Val Ile Leu 
225                 230                 235                 240 

Ser Leu His Pro His Asn Asp Arg Gly Thr Ala Val Ala Asp Ala Glu 
                245                 250                 255     

Leu Gly Leu Leu Ala Gly Gly Gln Arg Ile Glu Gly Thr Leu Phe Gly 
            260                 265                 270         

Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Val Thr Leu Ala Leu Asn 
        275                 280                 285             

Leu Phe Ser His Gly Val Asp Pro Gly Leu Asn Phe Ala Ser Met Leu 
    290                 295                 300                 

Glu Ile Thr Ala Lys Tyr Glu Ala Leu Thr Arg Met Lys Val His Asp 
305                 310                 315                 320 

Arg Gln Pro Tyr Gly Gly Lys Leu Val Phe Ala Ala Phe Ser Gly Ser 
                325                 330                 335     

His Gln Asp Ala Ile Thr Lys Gly Ile Lys Trp Arg Glu Glu His Glu 
            340                 345                 350         

Cys His Tyr Trp Asn Val Pro Tyr Leu Leu Ile Asp Pro Gln Asp Ile 
        355                 360                 365             

Gly Arg Glu Tyr Glu Gly Asp Val Ile Arg Ile Asn Ser Gln Ser Gly 
    370                 375                 380                 

Lys Gly Gly Ile Ala Tyr Met Leu Glu Gln His Tyr Ala Leu Asp Leu 
385                 390                 395                 400 

Pro Ala Lys Met Arg Glu Ala Phe Gly Tyr Lys Val Lys Asn Val Ser 
                405                 410                 415     

Asp Asn Leu His Lys Glu Leu Met Pro Glu Glu Ile Lys Asp Ile Phe 
            420                 425                 430         

Phe Lys Glu Tyr Val Asn Ile Glu Asn Pro Ile Lys Phe Leu Asn Phe 
        435                 440                 445             

His Phe Leu Asn His Asp Asp Phe Gln Thr Thr Val Thr Leu Glu Phe 
    450                 455                 460                 

Lys Gly Glu Ile Gln Glu Leu Ser Gly Glu Gly Asp Gly Arg Leu Asp 
465                 470                 475                 480 

Ala Ile Ser Asn Ala Leu Gln Ala Arg Leu Gly Leu Ser Tyr Ser Asn 
                485                 490                 495     

Leu Ile Tyr Lys Glu His Ala Leu Glu Leu Gly Ser Lys Ser Gln Ala 
            500                 505                 510         

Val Ser Tyr Val Gly Val Thr Gly Pro Asp Gly Val Ile His Trp Gly 
        515                 520                 525             

Cys Gly Ile His Thr Asp Ile Phe Thr Ser Ser Val Lys Ala Leu Ile 
    530                 535                 540                 

Ser Ala Ile Asn Thr Met Ile Lys Asp Ser Ala 
545                 550                 555 

<210>   1433
<211>   550
<212>   PRT
<213>   Ruminococcus obeum ATCC 29174

<400>   1433
Asn Met Lys Asn Val Thr Lys Tyr Gln Arg Gln Tyr Tyr Met Pro Pro 
                5                   10                  15      

Met Lys Cys Met Lys Trp Ala Glu Lys Glu Tyr Val Asp Lys Ala Pro 
            20                  25                  30          

Ile Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Val Ile 
        35                  40                  45              

Pro Met Ser Leu Glu Gln Lys Ile Glu Phe Phe Lys Leu Leu Val Lys 
    50                  55                  60                  

Ile Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Glu Thr 
65                  70                  75                  80  

Glu Tyr Thr Phe Val Arg Thr Leu Ile Glu Gln Asn Leu Ile Pro Asp 
                85                  90                  95      

Asp Val Thr Ile Gln Val Leu Thr Gln Ala Arg Glu His Ile Ile Arg 
            100                 105                 110         

Lys Thr Phe Glu Ala Val Lys Gly Ala Pro Lys Ala Ile Val His Val 
        115                 120                 125             

Tyr Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Lys Lys Ser 
    130                 135                 140                 

Lys Glu Glu Ile Leu Lys Ile Ala Val Asp Gly Ala Lys Leu Leu Lys 
145                 150                 155                 160 

Glu Leu Ala Asp Glu Thr Glu Gly Asn Phe Gln Phe Glu Tyr Ser Pro 
                165                 170                 175     

Glu Ser Phe Thr Gly Thr Glu Pro Glu Tyr Ala Leu Glu Val Cys Asn 
            180                 185                 190         

Ala Val Leu Asp Val Trp Gln Pro Thr Pro Glu Asn Lys Ala Ile Ile 
        195                 200                 205             

Asn Leu Pro Val Thr Val Glu Leu Ser Met Pro His Val Tyr Ala Ser 
    210                 215                 220                 

Gln Ile Glu Tyr Met Ser Glu Asn Met Lys Tyr Arg Glu Asn Val Ile 
225                 230                 235                 240 

Leu Ser Gln His Pro His Asn Asp Arg Gly Cys Gly Val Ala Asp Ser 
                245                 250                 255     

Glu Leu Gly Leu Leu Ala Gly Ala Asp Arg Val Glu Gly Thr Leu Phe 
            260                 265                 270         

Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Val Val Thr Leu Ala Met 
        275                 280                 285             

Asn Met Phe Ala Gln Gly Val Asp Pro Glu Leu Asp Phe Ser Asp Met 
    290                 295                 300                 

Pro His Ile Cys Glu Val Tyr Glu Ala Cys Thr Gly Met Lys Val Asp 
305                 310                 315                 320 

Glu Arg Ser Pro Tyr Ser Gly Ala Leu Val Phe Ala Ala Phe Ser Gly 
                325                 330                 335     

Ser His Gln Asp Ala Ile Ala Lys Gly Met His Trp Arg Asp Glu Lys 
            340                 345                 350         

Asp Pro Asn Arg Trp Thr Val Pro Tyr Leu Pro Ile Asp Pro Thr Asp 
        355                 360                 365             

Val Gly Arg Asn Tyr Asp Ala Asp Val Ile Arg Ile Asn Ser Gln Ser 
    370                 375                 380                 

Gly Lys Gly Gly Val Gly Tyr Ile Leu Glu Thr Lys Tyr Gly Leu Asn 
385                 390                 395                 400 

Leu Pro Pro Lys Met Arg Glu Ala Met Gly Tyr Ala Ala Lys Ala Val 
                405                 410                 415     

Ser Asp His Cys His Lys Glu Leu His Pro Asp Glu Ile Phe Asn Leu 
            420                 425                 430         

Phe Lys Ser Thr Phe Glu Asn Val Val Glu Pro Tyr Ser Ile Asp Glu 
        435                 440                 445             

Val His Phe Gln Gln Lys Asp Gly Gly Ile Thr Thr Gln Val Thr Ser 
    450                 455                 460                 

Thr Phe Asn Gly Lys Thr Ile Thr Thr Glu Ala Thr Gly Asn Gly Arg 
465                 470                 475                 480 

Leu Asp Ala Val Ser Asn Ala Leu Lys Lys Ala Tyr Glu Met Lys Phe 
                485                 490                 495     

Thr Leu Val Thr Tyr Gln Glu His Ala Leu Glu Lys Ser Ser Ser Ser 
            500                 505                 510         

Lys Ala Ile Ala Tyr Val Gly Ile Gln Lys Pro Asp Gly Thr Leu Ser 
        515                 520                 525             

Trp Gly Ala Gly Val Asp Pro Asp Ile Ile Arg Ala Ser Ile Asp Ala 
    530                 535                 540                 

Leu Val Thr Ala Ile Asn 
545                 550 

<210>   1434
<211>   549
<212>   PRT
<213>   Ruminococcus gnavus ATCC 29149

<400>   1434
Met Lys Asn Phe Glu Lys Tyr Glu Arg Ser Tyr Phe Met Pro Pro Val 
                5                   10                  15      

Pro Cys Tyr Asp Trp Val Lys Lys Asp His Ile Glu Lys Pro Pro Val 
            20                  25                  30          

Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile Glu Pro 
        35                  40                  45              

Met Ser Leu Glu Glu Lys Ile Glu Phe Phe Gln Met Leu Leu Asp Val 
    50                  55                  60                  

Gly Phe Lys Gln Ile Glu Val Gly Phe Pro Ala Ala Ser Glu Thr Glu 
65                  70                  75                  80  

Tyr Gln Phe Leu Arg Thr Leu Ile Glu Gln Asn Met Ile Pro Glu Asp 
                85                  90                  95      

Val Thr Ile Gln Val Leu Thr Gln Ala Arg Glu His Ile Ile Lys Arg 
            100                 105                 110         

Thr Phe Glu Ala Val Lys Gly Ala Pro His Ala Val Ile His Leu Tyr 
        115                 120                 125             

Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Lys Lys Asn Lys 
    130                 135                 140                 

Glu Glu Ile Lys Lys Ile Ala Val Asp Gly Ala Ile Leu Leu Asn Glu 
145                 150                 155                 160 

Leu Ala Lys Glu Thr Glu Gly Asn Phe Thr Phe Glu Tyr Ser Pro Glu 
                165                 170                 175     

Ser Phe Gln Gly Thr Glu Val Asp Tyr Ala Leu Glu Val Cys Asn Ala 
            180                 185                 190         

Val Leu Arg Val Trp Glu Pro Ser Arg Glu Arg Lys Val Ile Ile Asn 
        195                 200                 205             

Leu Pro Thr Thr Val Glu Asn Ala Met Pro His Val Phe Ala Ser Gln 
    210                 215                 220                 

Val Glu Tyr Met Ser Lys His Leu Tyr Asn Arg Glu His Val Leu Leu 
225                 230                 235                 240 

Ser Leu His Pro His Asn Asp Arg Gly Ser Gly Val Ser Asp Ala Glu 
                245                 250                 255     

Leu Gly Ile Leu Ala Gly Ala Asp Arg Ile Glu Gly Thr Leu Phe Gly 
            260                 265                 270         

Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Ile Thr Val Ala Met Asn 
        275                 280                 285             

Met Tyr Ser Gln Gly Val Asp Pro Gly Leu Asp Phe Ser Asn Met Ser 
    290                 295                 300                 

Glu Ile Ser Glu Thr Tyr Glu Arg Leu Thr Arg Met Gln Val Ser Pro 
305                 310                 315                 320 

Arg Gln Pro Tyr Ala Gly Glu Leu Val Phe Thr Ala Phe Ser Gly Ser 
                325                 330                 335     

His Gln Asp Ala Ile Ala Lys Gly Met Ala Trp Arg Glu Glu Lys Gln 
            340                 345                 350         

Cys Gln Thr Trp Ser Val Pro Tyr Leu Pro Leu Asp Pro Lys Asp Val 
        355                 360                 365             

Gly Arg Arg Tyr Glu Thr Asp Val Ile Arg Ile Asn Ser Gln Ser Gly 
    370                 375                 380                 

Lys Gly Gly Val Asn Tyr Ile Leu Lys Gln Ser Phe Gly Ile Ser Leu 
385                 390                 395                 400 

Pro Gln Lys Met Arg Glu Glu Val Gly Tyr Leu Val Lys Asp Val Ser 
                405                 410                 415     

Asp Lys Ala His Lys Glu Leu Thr Pro Asp Trp Val Tyr His Ile Phe 
            420                 425                 430         

Glu Asp His Tyr Ile His Val Lys Thr Ile Phe Thr Val Asp Glu Cys 
        435                 440                 445             

His Phe Lys Gln Glu Asp Gly Ile Leu Ala Glu Ala Thr Ile His His 
    450                 455                 460                 

Ala Gly Ser Asp Arg Val Ile Asn Gly Met Gly Asn Gly Arg Leu Asp 
465                 470                 475                 480 

Ala Val Ser Asn Ala Ile Lys His Tyr Phe Asp Ile Asp Tyr Glu Leu 
                485                 490                 495     

Ala Phe Tyr Glu Glu His Ser Met Thr Lys Gly Ser Ser Ser Lys Ala 
            500                 505                 510         

Val Ala Tyr Val Gly Val Ile Cys Asn Lys Lys Arg Tyr Trp Gly Val 
        515                 520                 525             

Gly Ile Asp Ala Asp Ile Ile Lys Ala Ser Val Glu Ala Leu Val Val 
    530                 535                 540                 

Ala Val Asn Lys Ile 
545                 

<210>   1435
<211>   551
<212>   PRT
<213>   Clostridium sp. L2-50

<400>   1435
Leu Asn Met Lys Asn Phe Glu His Tyr Lys Arg Gly Tyr Tyr Met Pro 
                5                   10                  15      

Pro Glu Lys Ser Val Lys Trp Val Glu Lys Glu Tyr Ile Asp Lys Ala 
            20                  25                  30          

Pro Ile Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile 
        35                  40                  45              

Val Pro Met Asn Leu Asp Glu Lys Leu Glu Phe Phe Lys Glu Leu Val 
    50                  55                  60                  

Arg Ile Gly Phe Lys Glu Ile Glu Ile Gly Phe Pro Ala Ala Ser Glu 
65                  70                  75                  80  

Thr Glu Tyr Glu Phe Cys Arg Thr Leu Ile Glu Lys Asn Met Ile Pro 
                85                  90                  95      

Asp Asp Val Thr Ile Gln Val Leu Thr Gln Ala Arg Pro His Ile Ile 
            100                 105                 110         

Lys Lys Thr Phe Glu Ala Ile Asp Gly Ala Lys His Ala Ile Val His 
        115                 120                 125             

Leu Tyr Asn Ser Thr Ser Tyr Ala Gln Arg Thr Gln Val Phe Lys Lys 
    130                 135                 140                 

Ser Lys Glu Glu Ile Leu Gln Leu Ala Val Asp Gly Ala Lys Leu Leu 
145                 150                 155                 160 

Asn Gln Met Ala Glu Glu His Gly Val Asn Tyr Pro Phe Glu Tyr Ser 
                165                 170                 175     

Pro Glu Ser Phe Thr Gly Thr Glu Ile Asp Tyr Ala Leu Asp Val Cys 
            180                 185                 190         

Asn Ala Val Ile Lys Glu Trp Lys Pro Thr Pro Asp Arg Lys Val Ile 
        195                 200                 205             

Ile Asn Leu Pro Ala Thr Val Glu Met Ser Leu Pro His Val Tyr Ala 
    210                 215                 220                 

Ser Gln Ile Glu Tyr Met Ser Glu His Leu Ile Asp Arg Glu Asn Val 
225                 230                 235                 240 

Ile Leu Ser Leu His Pro His Asn Asp Arg Gly Cys Gly Val Ala Asp 
                245                 250                 255     

Ala Glu Leu Gly Ile Leu Ala Gly Ala Asp Arg Ile Glu Gly Thr Leu 
            260                 265                 270         

Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Ile Thr Leu Ala 
        275                 280                 285             

Met Asn Met Phe Thr His Gly Val Asp Pro Glu Leu Asp Leu Ser Asp 
    290                 295                 300                 

Ile Pro Lys Leu Thr Glu Leu Tyr Glu Arg Val Thr Asn Met His Val 
305                 310                 315                 320 

Tyr Glu Arg Ser Pro Tyr Thr Gly Lys Leu Val Phe Ala Ala Phe Ser 
                325                 330                 335     

Gly Ser His Gln Asp Ala Ile Ala Lys Gly Met Lys Tyr Arg Lys Asp 
            340                 345                 350         

Gln Gly Asp Gly Met Trp Thr Val Pro Tyr Leu Pro Leu Asn Pro Glu 
        355                 360                 365             

Asp Ile Gly Arg Lys Tyr Asp Gly Asp Val Ile Arg Ile Asn Ser Gln 
    370                 375                 380                 

Ser Gly Lys Gly Gly Ile Gly Tyr Ile Leu Gln Ser Lys Tyr Gly Phe 
385                 390                 395                 400 

Asp Leu Pro Pro Lys Phe Arg Glu Asp Leu Gly Tyr Thr Val Lys Asp 
                405                 410                 415     

Val Ser Asp Lys Ala His Lys Glu Leu Ser Ala Thr Glu Val Leu Asp 
            420                 425                 430         

Ile Phe Gln Ser Thr Tyr Val Asn Ile Glu Asn Pro Val Arg Met Leu 
        435                 440                 445             

Glu Cys His Phe Val Gln Gly Asp Gly Ile Ser Thr Glu Ile Thr Ile 
    450                 455                 460                 

Met Lys Tyr Gly Glu Lys Lys Val Tyr His Gly Lys Gly Asn Gly Arg 
465                 470                 475                 480 

Leu Asp Ala Val Ser Asn Ala Ile Lys Lys His Phe Asp Ile Asp Phe 
                485                 490                 495     

Lys Ile Ile Cys Tyr Glu Glu His Ala Leu Gln Val Gly Ser Asn Ser 
            500                 505                 510         

Gln Ala Val Ala Tyr Val Gly Leu Glu Gly Lys Asp Gly Thr Val Thr 
        515                 520                 525             

Trp Gly Ala Gly Ile Lys Asp Asp Ile Ile Asp Ala Ser Val Tyr Ala 
    530                 535                 540                 

Leu Ile Ser Ala Ile Asn Arg 
545                 550     

<210>   1436
<211>   566
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1429

<400>   1436
Met Asp Met Asn Asn Val Asn Lys Tyr Thr Arg Gln Tyr Phe Leu Pro 
                5                   10                  15      

Pro Glu Pro Cys Phe Asp Trp Val His Lys Asp His Val Asp Arg Pro 
            20                  25                  30          

Pro Ile Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile 
        35                  40                  45              

Val Pro Met Asn Leu Glu Glu Lys Leu Ala Tyr Phe Gln Leu Leu Val 
    50                  55                  60                  

Glu Ile Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Asp 
65                  70                  75                  80  

Thr Glu Phe Glu Phe Val Arg Thr Leu Ile Glu Arg Asp Leu Val Pro 
                85                  90                  95      

Ser Asp Val Thr Ile Gln Val Leu Thr Gln Ser Arg Asp His Ile Ile 
            100                 105                 110         

Glu Arg Thr Phe Glu Ala Ile Arg Gly Ala Lys Arg Ala Ile Val His 
        115                 120                 125             

Leu Tyr Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Arg Ala 
    130                 135                 140                 

Asp Lys Asp Glu Ile Val Asn Ile Ala Val Thr Gly Ala Glu Gln Ile 
145                 150                 155                 160 

Arg Asp Leu Ala Arg Thr Thr Pro Gly Asn Phe Phe Phe Gln Tyr Ser 
                165                 170                 175     

Pro Glu Ser Phe Thr Gly Thr Glu Leu Asp Phe Ala Leu Glu Ile Cys 
            180                 185                 190         

Asn Ala Val Leu Asp Val Trp Lys Pro Thr Pro Asp Arg Lys Val Ile 
        195                 200                 205             

Ile Asn Leu Pro Ala Thr Val Glu Leu Ser Met Pro His Val Tyr Ala 
    210                 215                 220                 

Ser Gln Ile Glu Tyr Met Gly Lys Arg Leu Ala Arg Arg Asp Ala Ile 
225                 230                 235                 240 

Val Leu Ser Val His Pro His Asn Asp Arg Gly Thr Gly Val Ala Ala 
                245                 250                 255     

Ala Glu Leu Ala Met Leu Ala Gly Ala Glu Arg Leu Glu Gly Thr Leu 
            260                 265                 270         

Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Val Thr Leu Ala 
        275                 280                 285             

Leu Asn Leu Tyr Ser His Gly Ile Asp Pro Gly Leu Asp Phe Ser Asn 
    290                 295                 300                 

Leu Pro Ala Ile Gln Ala Arg Val Glu Ala Leu Thr Lys Met Gln Val 
305                 310                 315                 320 

Ser Arg Arg His Pro Tyr Ala Gly Glu Leu Val Phe Thr Ala Phe Ser 
                325                 330                 335     

Gly Ser His Gln Asp Ala Ile Ala Lys Gly Met Lys Trp Arg Glu Glu 
            340                 345                 350         

Lys Ser Pro Glu His Trp Thr Val Pro Tyr Leu Pro Ile Asp Pro Lys 
        355                 360                 365             

Asp Ile Gly Arg Glu Tyr Glu Gly Asp Ile Ile Arg Ile Asn Ser Gln 
    370                 375                 380                 

Ser Gly Lys Gly Gly Ile Gly Tyr Val Leu Glu Gln Ser His Gly Phe 
385                 390                 395                 400 

Asp Leu Pro Pro Lys Met Arg Glu Gln Leu Gly Tyr Ala Val Lys Arg 
                405                 410                 415     

Val Ser Asp Arg Glu Gln Lys Glu Leu Ser Ala Asp Glu Ile Ala Glu 
            420                 425                 430         

Ile Phe Met Arg Glu Phe Val Asn Leu Gly Gln Pro Leu Asp Leu Val 
        435                 440                 445             

Glu Leu Thr Gly Thr Asp Ala Arg Gly Ser His Lys Val Arg Ala Thr 
    450                 455                 460                 

Val Val Trp Gln Gly Glu Thr Val Glu Ile Glu Gly Ala Gly Asn Gly 
465                 470                 475                 480 

Arg Leu Asp Ala Leu Cys His Ala Leu Glu Glu Gly Leu Gly Ile Arg 
                485                 490                 495     

Val Ala Asn Leu Thr Tyr Lys Glu His Ala Leu Glu Val Gly Ser Gly 
            500                 505                 510         

Ser Arg Ala Val Ala Tyr Ile Ser Val Asp Asp Glu Glu Gly Asn Thr 
        515                 520                 525             

His Phe Gly Cys Gly Val Asp Thr Asp Ile Met Glu Ala Ser Ala Lys 
    530                 535                 540                 

Ala Leu Val Ser Ala Val Asn Arg Met Leu Ala His Arg Ala Glu Met 
545                 550                 555                 560 

Ala Val Pro Val Ser Lys 
                565     

<210>   1437
<211>   566
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1429

<400>   1437
Met Asp Met Asn Asn Val Asn Lys Tyr Thr Arg Gln Tyr Phe Leu Pro 
                5                   10                  15      

Pro Glu Pro Cys Phe Asp Trp Val His Lys Asp His Val Asp Arg Pro 
            20                  25                  30          

Pro Ile Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile 
        35                  40                  45              

Val Pro Met Asn Leu Glu Glu Lys Leu Ala Tyr Phe Gln Leu Leu Val 
    50                  55                  60                  

Glu Ile Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Asp 
65                  70                  75                  80  

Thr Glu Phe Glu Phe Val Arg Thr Leu Ile Glu Arg Asp Leu Val Pro 
                85                  90                  95      

Ser Asp Val Thr Ile Gln Val Leu Thr Gln Ser Arg Asp His Ile Ile 
            100                 105                 110         

Glu Arg Thr Phe Glu Ala Ile Arg Gly Ala Lys Arg Ala Ile Val His 
        115                 120                 125             

Leu Tyr Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Arg Ala 
    130                 135                 140                 

Asp Lys Asp Glu Ile Val Asn Ile Ala Val Thr Gly Ala Glu Gln Ile 
145                 150                 155                 160 

Arg Asp Leu Ala Arg Thr Thr Pro Gly Asn Phe Phe Phe Gln Tyr Ser 
                165                 170                 175     

Pro Glu Ser Phe Thr Gly Thr Glu Leu Asp Phe Ala Leu Glu Ile Cys 
            180                 185                 190         

Asn Ala Val Leu Asp Val Trp Lys Pro Thr Pro Asp Arg Lys Val Ile 
        195                 200                 205             

Ile Asn Leu Pro Ala Thr Val Glu Leu Ser Met Pro His Val Tyr Ala 
    210                 215                 220                 

Ser Gln Ile Glu Tyr Met Gly Lys Arg Leu Ala Arg Arg Asp Ala Ile 
225                 230                 235                 240 

Val Leu Ser Val His Pro His Asn Asp Arg Gly Thr Gly Val Ala Ala 
                245                 250                 255     

Ala Glu Leu Ala Met Leu Ala Gly Ala Glu Arg Leu Glu Gly Thr Leu 
            260                 265                 270         

Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Val Thr Leu Ala 
        275                 280                 285             

Leu Asn Leu Tyr Ser His Gly Ile Asp Pro Gly Leu Asp Phe Ser Asn 
    290                 295                 300                 

Leu Pro Ala Ile Gln Ala Arg Val Glu Ala Leu Thr Lys Met Gln Val 
305                 310                 315                 320 

Ser Arg Arg His Pro Tyr Ala Gly Glu Leu Val Phe Thr Ala Phe Ser 
                325                 330                 335     

Gly Ser His Gln Asp Ala Ile Ala Lys Gly Met Lys Trp Arg Glu Glu 
            340                 345                 350         

Lys Ser Pro Glu His Trp Thr Val Pro Tyr Leu Pro Ile Asp Pro Lys 
        355                 360                 365             

Asp Ile Gly Arg Glu Tyr Glu Gly Asp Ile Ile Arg Ile Asn Ser Gln 
    370                 375                 380                 

Ser Gly Lys Gly Gly Ile Gly Tyr Val Leu Glu Gln Ser His Gly Phe 
385                 390                 395                 400 

Asp Leu Pro Pro Lys Met Arg Glu Gln Leu Gly Tyr Ala Val Lys Arg 
                405                 410                 415     

Val Ser Asp Arg Glu Gln Lys Glu Leu Ser Ala Asp Glu Ile Ala Glu 
            420                 425                 430         

Ile Phe Met Arg Glu Phe Val Asn Leu Gly Gln Pro Leu Asp Leu Val 
        435                 440                 445             

Glu Leu Thr Gly Thr Asp Ala Arg Gly Ser His Arg Val Arg Ala Thr 
    450                 455                 460                 

Val Val Trp Gln Gly Glu Thr Val Glu Ile Glu Gly Ala Gly Asn Gly 
465                 470                 475                 480 

Arg Leu Asp Ala Leu Cys His Ala Leu Glu Glu Gly Leu Gly Ile Arg 
                485                 490                 495     

Val Ala Asn Ile Thr Tyr Lys Glu His Ala Leu Glu Val Gly Ser Gly 
            500                 505                 510         

Ser Arg Ala Val Ala Tyr Ile Ser Val Asp Asp Glu Glu Gly Asn Thr 
        515                 520                 525             

His Phe Gly Cys Gly Val Asp Thr Asp Ile Met Glu Ala Ser Ala Lys 
    530                 535                 540                 

Ala Leu Val Ser Ala Val Asn Arg Met Leu Ala His Arg Ala Glu Met 
545                 550                 555                 560 

Ala Val Pro Val Ser Lys 
                565     

<210>   1438
<211>   566
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1429

<400>   1438
Met Asp Met Asn Asn Val Asn Lys Tyr Thr Arg Gln Tyr Phe Leu Pro 
                5                   10                  15      

Pro Glu Pro Cys Phe Asp Trp Val His Lys Asp His Val Asp Arg Pro 
            20                  25                  30          

Pro Ile Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile 
        35                  40                  45              

Val Pro Met Asn Leu Glu Glu Lys Leu Ala Tyr Phe Gln Leu Leu Val 
    50                  55                  60                  

Glu Ile Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Asp 
65                  70                  75                  80  

Thr Glu Phe Glu Phe Val Arg Thr Leu Ile Glu Arg Asp Leu Val Pro 
                85                  90                  95      

Ser Asp Val Thr Ile Gln Val Leu Thr Gln Ser Arg Asp His Ile Ile 
            100                 105                 110         

Glu Arg Thr Phe Glu Ala Ile Arg Gly Ala Lys Arg Ala Ile Val His 
        115                 120                 125             

Leu Tyr Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Arg Ala 
    130                 135                 140                 

Asp Lys Asp Glu Ile Val Asn Ile Ala Val Thr Gly Ala Glu Gln Ile 
145                 150                 155                 160 

Arg Asp Leu Ala Arg Thr Thr Pro Gly Asn Phe Phe Phe Gln Tyr Ser 
                165                 170                 175     

Pro Glu Ser Phe Thr Gly Thr Glu Ile Asp Phe Ala Leu Glu Ile Cys 
            180                 185                 190         

Asn Ala Val Leu Asp Val Trp Lys Pro Thr Pro Asp Arg Lys Val Ile 
        195                 200                 205             

Ile Asn Leu Pro Ala Thr Val Glu Leu Ser Met Pro His Val Tyr Ala 
    210                 215                 220                 

Ser Gln Ile Glu Tyr Met Gly Lys Arg Leu Ala Arg Arg Asp Ala Ile 
225                 230                 235                 240 

Val Leu Ser Val His Pro His Asn Asp Arg Gly Thr Gly Val Ala Ala 
                245                 250                 255     

Ala Glu Leu Ala Met Leu Ala Gly Ala Glu Arg Leu Glu Gly Thr Leu 
            260                 265                 270         

Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Val Thr Leu Ala 
        275                 280                 285             

Leu Asn Leu Tyr Ser His Gly Ile Asp Pro Gly Leu Asp Phe Ser Asn 
    290                 295                 300                 

Leu Pro Ala Ile Gln Ala Arg Val Glu Ala Leu Thr Lys Met Gln Val 
305                 310                 315                 320 

Ser Arg Arg His Pro Tyr Ala Gly Glu Leu Val Phe Thr Ala Phe Ser 
                325                 330                 335     

Gly Ser His Gln Asp Ala Ile Ala Lys Gly Met Lys Trp Arg Glu Glu 
            340                 345                 350         

Lys Ser Pro Glu His Trp Thr Val Pro Tyr Leu Pro Ile Asp Pro Lys 
        355                 360                 365             

Asp Ile Gly Arg Glu Tyr Glu Gly Asp Ile Ile Arg Ile Asn Ser Gln 
    370                 375                 380                 

Ser Gly Lys Gly Gly Ile Gly Tyr Val Leu Glu Gln Ser His Gly Phe 
385                 390                 395                 400 

Asp Leu Pro Pro Lys Met Arg Glu Gln Leu Gly Tyr Ala Val Lys Arg 
                405                 410                 415     

Val Ser Asp Arg Glu Gln Lys Glu Leu Ser Ala Asp Glu Ile Ala Glu 
            420                 425                 430         

Ile Phe Met Arg Glu Phe Val Asn Leu Gly Gln Pro Leu Asp Leu Val 
        435                 440                 445             

Glu Leu Thr Gly Thr Asp Ala Arg Gly Ser His Arg Val Arg Ala Thr 
    450                 455                 460                 

Val Val Trp Gln Gly Glu Thr Val Glu Ile Glu Gly Ala Gly Asn Gly 
465                 470                 475                 480 

Arg Leu Asp Ala Leu Cys His Ala Leu Glu Glu Gly Leu Gly Ile Arg 
                485                 490                 495     

Val Ala Asn Leu Thr Tyr Lys Glu His Ala Leu Glu Val Gly Ser Gly 
            500                 505                 510         

Ser Arg Ala Val Ala Tyr Ile Ser Val Asp Asp Glu Glu Gly Asn Thr 
        515                 520                 525             

His Phe Gly Cys Gly Val Asp Thr Asp Ile Met Glu Ala Ser Ala Lys 
    530                 535                 540                 

Ala Leu Val Ser Ala Val Asn Arg Met Leu Ala His Arg Ala Glu Met 
545                 550                 555                 560 

Ala Val Pro Val Ser Lys 
                565     

<210>   1439
<211>   566
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1429

<400>   1439
Met Asp Met Asn Asn Val Asn Lys Tyr Thr Arg Gln Tyr Phe Leu Pro 
                5                   10                  15      

Pro Glu Pro Cys Phe Asp Trp Val His Lys Asp His Val Asp Arg Pro 
            20                  25                  30          

Pro Ile Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile 
        35                  40                  45              

Val Pro Met Asn Leu Glu Glu Lys Leu Ala Tyr Phe Gln Leu Leu Val 
    50                  55                  60                  

Glu Ile Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Asp 
65                  70                  75                  80  

Thr Glu Phe Glu Phe Val Arg Thr Leu Ile Glu Arg Asp Leu Val Pro 
                85                  90                  95      

Ser Asp Val Thr Ile Gln Val Leu Thr Gln Ser Arg Asp His Ile Ile 
            100                 105                 110         

Glu Arg Thr Phe Glu Ala Ile Arg Gly Ala Lys Arg Ala Ile Val His 
        115                 120                 125             

Leu Tyr Asn Ser Thr Ser Val Ala Gln Arg Asp Gln Val Phe Arg Ala 
    130                 135                 140                 

Asp Lys Asp Glu Ile Val Asn Ile Ala Val Thr Gly Ala Glu Gln Ile 
145                 150                 155                 160 

Arg Asp Leu Ala Arg Thr Thr Pro Gly Asn Phe Phe Phe Gln Tyr Ser 
                165                 170                 175     

Pro Glu Ser Phe Thr Gly Thr Glu Leu Asp Phe Ala Leu Glu Ile Cys 
            180                 185                 190         

Asn Ala Val Leu Asp Val Trp Lys Pro Thr Pro Asp Arg Lys Val Ile 
        195                 200                 205             

Ile Asn Leu Pro Ala Thr Val Glu Leu Ser Met Pro His Val Tyr Ala 
    210                 215                 220                 

Ser Gln Ile Glu Tyr Met Gly Lys Arg Leu Ala Arg Arg Asp Ala Ile 
225                 230                 235                 240 

Val Leu Ser Val His Pro His Asn Asp Arg Gly Thr Gly Val Ala Ala 
                245                 250                 255     

Ala Glu Leu Ala Met Leu Ala Gly Ala Glu Arg Leu Glu Gly Thr Leu 
            260                 265                 270         

Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Val Thr Leu Ala 
        275                 280                 285             

Leu Asn Leu Tyr Ser His Gly Ile Asp Pro Gly Leu Asp Phe Ser Asn 
    290                 295                 300                 

Leu Pro Ala Ile Gln Ala Arg Val Glu Ala Leu Thr Lys Met Gln Val 
305                 310                 315                 320 

Ser Arg Arg His Pro Tyr Ala Gly Glu Leu Val Phe Thr Ala Phe Ser 
                325                 330                 335     

Gly Ser His Gln Asp Ala Ile Ala Lys Gly Met Lys Trp Arg Glu Glu 
            340                 345                 350         

Lys Ser Pro Glu His Trp Thr Val Pro Tyr Leu Pro Ile Asp Pro Lys 
        355                 360                 365             

Asp Ile Gly Arg Glu Tyr Glu Gly Asp Ile Ile Arg Ile Asn Ser Gln 
    370                 375                 380                 

Ser Gly Lys Gly Gly Ile Gly Tyr Val Leu Glu Gln Ser His Gly Phe 
385                 390                 395                 400 

Asp Leu Pro Pro Lys Met Arg Glu Gln Leu Gly Tyr Ala Val Lys Arg 
                405                 410                 415     

Val Ser Asp Arg Glu Gln Lys Glu Leu Ser Ala Asp Glu Ile Ala Glu 
            420                 425                 430         

Ile Phe Met Arg Glu Phe Val Asn Leu Gly Gln Pro Leu Asp Leu Val 
        435                 440                 445             

Glu Leu Thr Gly Thr Asp Ala Arg Gly Ser His Arg Val Arg Ala Thr 
    450                 455                 460                 

Val Val Trp Gln Gly Glu Thr Val Glu Ile Glu Gly Ala Gly Asn Gly 
465                 470                 475                 480 

Arg Leu Asp Ala Leu Cys His Ala Leu Glu Glu Gly Leu Gly Ile Arg 
                485                 490                 495     

Val Ala Asn Leu Thr Tyr Lys Glu His Ala Leu Glu Val Gly Ser Gly 
            500                 505                 510         

Ser Arg Ala Val Ala Tyr Ile Ser Val Asp Asp Glu Glu Gly Asn Thr 
        515                 520                 525             

His Phe Gly Cys Gly Val Asp Thr Asp Ile Met Glu Ala Ser Ala Lys 
    530                 535                 540                 

Ala Leu Val Ser Ala Val Asn Arg Met Leu Ala His Arg Ala Glu Met 
545                 550                 555                 560 

Ala Val Pro Val Ser Lys 
                565     

<210>   1440
<211>   566
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1429

<400>   1440
Met Asp Met Asn Asn Val Asn Lys Tyr Thr Arg Gln Tyr Phe Leu Pro 
                5                   10                  15      

Pro Glu Pro Cys Phe Asp Trp Val His Lys Asp His Val Asp Arg Pro 
            20                  25                  30          

Pro Ile Trp Cys Ser Val Asp Leu Arg Asp Gly Asn Gln Ala Leu Ile 
        35                  40                  45              

Val Pro Met Asn Leu Glu Glu Lys Leu Ala Tyr Phe Gln Leu Leu Val 
    50                  55                  60                  

Glu Ile Gly Phe Lys Glu Ile Glu Val Gly Phe Pro Ala Ala Ser Asp 
65                  70                  75                  80  

Thr Glu Phe Glu Phe Val Arg Thr Leu Ile Glu Arg Asp Leu Val Pro 
                85                  90                  95      

Ser Asp Val Thr Ile Gln Val Leu Thr Gln Ser Arg Asp His Ile Ile 
            100                 105                 110         

Glu Arg Thr Phe Glu Ala Ile Arg Gly Ala Lys Arg Ala Ile Val His 
        115                 120                 125             

Leu Tyr Asn Ser Thr Ser Val Ala Gln Arg Glu Gln Val Phe Arg Ala 
    130                 135                 140                 

Asp Lys Asp Glu Ile Val Asn Ile Ala Val Thr Gly Ala Glu Gln Ile 
145                 150                 155                 160 

Arg Asp Leu Ala Arg Thr Thr Pro Gly Asn Phe Phe Phe Gln Tyr Ser 
                165                 170                 175     

Pro Glu Ser Phe Thr Gly Thr Glu Leu Asp Phe Ala Leu Glu Ile Cys 
            180                 185                 190         

Asn Ala Val Leu Asp Val Trp Lys Pro Thr Pro Asp Arg Lys Val Ile 
        195                 200                 205             

Ile Asn Leu Pro Ala Thr Val Glu Leu Ser Met Pro His Val Tyr Ala 
    210                 215                 220                 

Ser Gln Ile Glu Tyr Met Gly Lys Arg Leu Ala Arg Arg Asp Ala Ile 
225                 230                 235                 240 

Val Leu Ser Val His Pro His Asn Asp Arg Gly Thr Gly Val Ala Ala 
                245                 250                 255     

Ala Glu Leu Ala Met Leu Ala Gly Ala Glu Arg Leu Glu Gly Thr Leu 
            260                 265                 270         

Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Ile Val Thr Leu Ala 
        275                 280                 285             

Leu Asn Leu Tyr Ser His Gly Ile Asp Pro Gly Leu Asp Phe Ser Asn 
    290                 295                 300                 

Leu Pro Ala Ile Gln Ala Arg Val Glu Ala Leu Thr Lys Met Gln Val 
305                 310                 315                 320 

Ser Arg Arg His Pro Tyr Ala Gly Glu Leu Val Phe Thr Ala Phe Ser 
                325                 330                 335     

Gly Ser His Gln Asp Ala Ile Ala Lys Gly Met Lys Trp Arg Glu Glu 
            340                 345                 350         

Lys Ser Pro Glu His Trp Thr Val Pro Tyr Leu Pro Ile Asp Pro Lys 
        355                 360                 365             

Asp Ile Gly Arg Glu Tyr Glu Gly Asp Ile Ile Arg Ile Asn Ser Gln 
    370                 375                 380                 

Ser Gly Lys Gly Gly Ile Gly Tyr Val Leu Glu Gln Ser His Gly Phe 
385                 390                 395                 400 

Asp Leu Pro Pro Lys Met Arg Glu Gln Leu Gly Tyr Ala Val Lys Arg 
                405                 410                 415     

Val Ser Asp Arg Glu Gln Lys Glu Leu Ser Ala Asp Glu Ile Ala Glu 
            420                 425                 430         

Ile Phe Met Arg Glu Phe Ile Asn Leu Gly Gln Pro Leu Asp Leu Val 
        435                 440                 445             

Glu Leu Thr Gly Thr Asp Ala Arg Gly Ser His Arg Val Arg Ala Thr 
    450                 455                 460                 

Val Val Trp Gln Gly Glu Thr Val Glu Ile Glu Gly Ala Gly Asn Gly 
465                 470                 475                 480 

Arg Leu Asp Ala Leu Cys His Ala Leu Glu Glu Gly Leu Gly Ile Arg 
                485                 490                 495     

Val Ala Asn Leu Thr Tyr Lys Glu His Ala Leu Glu Val Gly Ser Gly 
            500                 505                 510         

Ser Arg Ala Val Ala Tyr Ile Ser Val Asp Asp Glu Glu Gly Asn Thr 
        515                 520                 525             

His Phe Gly Cys Gly Val Asp Thr Asp Ile Met Glu Ala Ser Ala Lys 
    530                 535                 540                 

Ala Leu Val Ser Ala Val Asn Arg Met Leu Ala His Arg Ala Glu Met 
545                 550                 555                 560 

Ala Val Pro Val Ser Lys 
                565     

<210>   1441
<211>   1701
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1430

<400>   1441
atggacatga acaacgtgaa caagtacacc cgccagtatt ttctgccgcc tgaaccctgc       60

ttcgactggg ttcacaagga ccatgtggac cgaccgccga tctggtgcag cgtcgacctg      120

cgcgacggaa atcaggcgct catcgttccg atgaatctcg aggagaagct tgcgtacttt      180

caactgctcg tcgagatcgg cttcaaggag atcgaggtcg gtttcccggc cgcatcggac      240

acggaattcg agttcgtccg gacgctcatc gagcgcgatc tcgtcccgag cgatgtgacc      300

atccaggtcc tcacgcaatc gcgcgatcac atcatcgaac gcacttttga agccattcgc      360

ggggccaagc gggccatcgt ccatctctac aactccacgt ccgtggcgca gcgcgagcag      420

gtgttccgcg cggacaagga cgagatcgtg aacattgccg tgaccggcgc cgaacagatc      480

cgcgatctcg cccgcaccac gcccggcaac ttcttcttcc aatattcacc ggagagcttc      540

acgggtacgg agctcgactt cgcgctcgag atctgcaacg cggtgctcga cgtgtggaaa      600

cccacgccgg atcgcaaggt catcatcaac ctgccggcga ccgtcgagct ttcgatgccg      660

cacgtgtacg cgagccagat cgagtacatg ggcaagcgcc tggctcgccg cgatgccatc      720

gtgctgtccg tgcatccgca caacgatcgc ggcacgggtg tcgcggcggc tgaactcgcc      780

atgctcgcgg gcgcggagcg gctggagggc acgctgtttg ggaacgggga gcgcacgggc      840

aacgtggaca tcgtcacgct cgcgctgaac ctgtactcgc acggcatcga tccggggctc      900

gacttctcca acctcccggc catccaggcc cgtgttgagg ctctcaccaa gatgcaggtg      960

agcaggcgtc acccgtacgc gggggaactc gtcttcacgg cgttttcggg atcgcatcaa     1020

gacgcgatcg cgaagggcat gaagtggcgc gaggagaagt cgcctgagca ttggacggtc     1080

ccgtatctgc ccatcgaccc gaaggatatt ggccgcgaat acgaggggga tatcatccgc     1140

atcaacagcc agtctggcaa gggcggcatc ggctacgtgt tggagcaatc gcacggcttc     1200

gatctgcctc caaagatgcg cgagcagctg gggtatgcgg tcaagcgggt gtcggatcgc     1260

gagcagaagg agctgtcggc ggacgagatc gccgagatct tcatgcgcga gtttgtgaac     1320

cttgggcagc cgctcgatct cgtcgaactg acgggcacgg atgcgagagg gtcgcacaaa     1380

gtgcgcgcca cggtggtctg gcagggcgag accgtcgaga tcgaaggggc cggcaatggg     1440

cggttggacg cgctgtgcca tgcgctggag gaggggctcg ggatccgggt cgcgaatctc     1500

acgtacaagg aacatgcgct ggaagtaggg tcgggatcgc gagcggtggc ttacatcagc     1560

gtcgacgacg aagaagggaa tacccacttc gggtgcggcg tggataccga cattatggag     1620

gcgtcggcga aggcgctggt gagcgcggtc aatcgaatgc tggcgcacag ggcggagatg     1680

gcggtgcccg tgagcaaatg a                                               1701


<210>   1442
<211>   1701
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1430

<400>   1442
atggacatga acaacgtgaa caagtacacc cgccagtatt ttctgccgcc tgaaccctgc       60

ttcgactggg ttcacaagga ccatgtggac cgaccgccga tctggtgcag cgtcgacctg      120

cgcgacggaa atcaggcgct catcgttccg atgaatctcg aggagaagct tgcgtacttt      180

caactgctcg tcgagatcgg cttcaaggag atcgaggtcg gtttcccggc cgcatcggac      240

acggaattcg agttcgtccg gacgctcatc gagcgcgatc tcgtcccgag cgatgtgacc      300

atccaggtcc tcacgcaatc gcgcgatcac atcatcgaac gcacttttga agccattcgc      360

ggggccaagc gggccatcgt ccatctctac aactccacgt ccgtggcgca gcgcgagcag      420

gtgttccgcg cggacaagga cgagatcgtg aacattgccg tgaccggcgc cgaacagatc      480

cgcgatctcg cccgcaccac gcccggcaac ttcttcttcc aatattcacc ggagagcttc      540

acgggtacgg agctcgactt cgcgctcgag atctgcaacg cggtgctcga cgtgtggaaa      600

cccacgccgg atcgcaaggt catcatcaac ctgccggcga ccgtcgagct ttcgatgccg      660

cacgtgtacg cgagccagat cgagtacatg ggcaagcgcc tggctcgccg cgatgccatc      720

gtgctgtccg tgcatccgca caacgatcgc ggcacgggtg tcgcggcggc tgaactcgcc      780

atgctcgcgg gcgcggagcg gctggagggc acgctgtttg ggaacgggga gcgcacgggc      840

aacgtggaca tcgtcacgct cgcgctgaac ctgtactcgc acggcatcga tccggggctc      900

gacttctcca acctcccggc catccaggcc cgtgttgagg ctctcaccaa gatgcaggtg      960

agcaggcgtc acccgtacgc gggggaactc gtcttcacgg cgttttcggg atcgcatcaa     1020

gacgcgatcg cgaagggcat gaagtggcgc gaggagaagt cgcctgagca ttggacggtc     1080

ccgtatctgc ccatcgaccc gaaggatatt ggccgcgaat acgaggggga tatcatccgc     1140

atcaacagcc agtctggcaa gggcggcatc ggctacgtgt tggagcaatc gcacggcttc     1200

gatctgcctc caaagatgcg cgagcagctg gggtatgcgg tcaagcgggt gtcggatcgc     1260

gagcagaagg agctgtcggc ggacgagatc gccgagatct tcatgcgcga gtttgtgaac     1320

cttgggcagc cgctcgatct cgtcgaactg acgggcacgg atgcgagagg gtcgcaccgc     1380

gtgcgcgcca cggtggtctg gcagggcgag accgtcgaga tcgaaggggc cggcaatggg     1440

cggttggacg cgctgtgcca tgcgctggag gaggggctcg ggatccgggt cgcgaatatt     1500

acgtacaagg aacatgcgct ggaagtaggg tcgggatcgc gagcggtggc ttacatcagc     1560

gtcgacgacg aagaagggaa tacccacttc gggtgcggcg tggataccga cattatggag     1620

gcgtcggcga aggcgctggt gagcgcggtc aatcgaatgc tggcgcacag ggcggagatg     1680

gcggtgcccg tgagcaaatg a                                               1701


<210>   1443
<211>   1701
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1430

<400>   1443
atggacatga acaacgtgaa caagtacacc cgccagtatt ttctgccgcc tgaaccctgc       60

ttcgactggg ttcacaagga ccatgtggac cgaccgccga tctggtgcag cgtcgacctg      120

cgcgacggaa atcaggcgct catcgttccg atgaatctcg aggagaagct tgcgtacttt      180

caactgctcg tcgagatcgg cttcaaggag atcgaggtcg gtttcccggc cgcatcggac      240

acggaattcg agttcgtccg gacgctcatc gagcgcgatc tcgtcccgag cgatgtgacc      300

atccaggtcc tcacgcaatc gcgcgatcac atcatcgaac gcacttttga agccattcgc      360

ggggccaagc gggccatcgt ccatctctac aactccacgt ccgtggcgca gcgcgagcag      420

gtgttccgcg cggacaagga cgagatcgtg aacattgccg tgaccggcgc cgaacagatc      480

cgcgatctcg cccgcaccac gcccggcaac ttcttcttcc aatattcacc ggagagcttc      540

acgggtacgg agattgactt cgcgctcgag atctgcaacg cggtgctcga cgtgtggaaa      600

cccacgccgg atcgcaaggt catcatcaac ctgccggcga ccgtcgagct ttcgatgccg      660

cacgtgtacg cgagccagat cgagtacatg ggcaagcgcc tggctcgccg cgatgccatc      720

gtgctgtccg tgcatccgca caacgatcgc ggcacgggtg tcgcggcggc tgaactcgcc      780

atgctcgcgg gcgcggagcg gctggagggc acgctgtttg ggaacgggga gcgcacgggc      840

aacgtggaca tcgtcacgct cgcgctgaac ctgtactcgc acggcatcga tccggggctc      900

gacttctcca acctcccggc catccaggcc cgtgttgagg ctctcaccaa gatgcaggtg      960

agcaggcgtc acccgtacgc gggggaactc gtcttcacgg cgttttcggg atcgcatcaa     1020

gacgcgatcg cgaagggcat gaagtggcgc gaggagaagt cgcctgagca ttggacggtc     1080

ccgtatctgc ccatcgaccc gaaggatatt ggccgcgaat acgaggggga tatcatccgc     1140

atcaacagcc agtctggcaa gggcggcatc ggctacgtgt tggagcaatc gcacggcttc     1200

gatctgcctc caaagatgcg cgagcagctg gggtatgcgg tcaagcgggt gtcggatcgc     1260

gagcagaagg agctgtcggc ggacgagatc gccgagatct tcatgcgcga gtttgtgaac     1320

cttgggcagc cgctcgatct cgtcgaactg acgggcacgg atgcgagagg gtcgcaccgc     1380

gtgcgcgcca cggtggtctg gcagggcgag accgtcgaga tcgaaggggc cggcaatggg     1440

cggttggacg cgctgtgcca tgcgctggag gaggggctcg ggatccgggt cgcgaatctc     1500

acgtacaagg aacatgcgct ggaagtaggg tcgggatcgc gagcggtggc ttacatcagc     1560

gtcgacgacg aagaagggaa tacccacttc gggtgcggcg tggataccga cattatggag     1620

gcgtcggcga aggcgctggt gagcgcggtc aatcgaatgc tggcgcacag ggcggagatg     1680

gcggtgcccg tgagcaaatg a                                               1701


<210>   1444
<211>   1701
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1430

<400>   1444
atggacatga acaacgtgaa caagtacacc cgccagtatt ttctgccgcc tgaaccctgc       60

ttcgactggg ttcacaagga ccatgtggac cgaccgccga tctggtgcag cgtcgacctg      120

cgcgacggaa atcaggcgct catcgttccg atgaatctcg aggagaagct tgcgtacttt      180

caactgctcg tcgagatcgg cttcaaggag atcgaggtcg gtttcccggc cgcatcggac      240

acggaattcg agttcgtccg gacgctcatc gagcgcgatc tcgtcccgag cgatgtgacc      300

atccaggtcc tcacgcaatc gcgcgatcac atcatcgaac gcacttttga agccattcgc      360

ggggccaagc gggccatcgt ccatctctac aactccacgt ccgtggcgca gcgcgatcag      420

gtgttccgcg cggacaagga cgagatcgtg aacattgccg tgaccggcgc cgaacagatc      480

cgcgatctcg cccgcaccac gcccggcaac ttcttcttcc aatattcacc ggagagcttc      540

acgggtacgg agctcgactt cgcgctcgag atctgcaacg cggtgctcga cgtgtggaaa      600

cccacgccgg atcgcaaggt catcatcaac ctgccggcga ccgtcgagct ttcgatgccg      660

cacgtgtacg cgagccagat cgagtacatg ggcaagcgcc tggctcgccg cgatgccatc      720

gtgctgtccg tgcatccgca caacgatcgc ggcacgggtg tcgcggcggc tgaactcgcc      780

atgctcgcgg gcgcggagcg gctggagggc acgctgtttg ggaacgggga gcgcacgggc      840

aacgtggaca tcgtcacgct cgcgctgaac ctgtactcgc acggcatcga tccggggctc      900

gacttctcca acctcccggc catccaggcc cgtgttgagg ctctcaccaa gatgcaggtg      960

agcaggcgtc acccgtacgc gggggaactc gtcttcacgg cgttttcggg atcgcatcaa     1020

gacgcgatcg cgaagggcat gaagtggcgc gaggagaagt cgcctgagca ttggacggtc     1080

ccgtatctgc ccatcgaccc gaaggatatt ggccgcgaat acgaggggga tatcatccgc     1140

atcaacagcc agtctggcaa gggcggcatc ggctacgtgt tggagcaatc gcacggcttc     1200

gatctgcctc caaagatgcg cgagcagctg gggtatgcgg tcaagcgggt gtcggatcgc     1260

gagcagaagg agctgtcggc ggacgagatc gccgagatct tcatgcgcga gtttgtgaac     1320

cttgggcagc cgctcgatct cgtcgaactg acgggcacgg atgcgagagg gtcgcaccgc     1380

gtgcgcgcca cggtggtctg gcagggcgag accgtcgaga tcgaaggggc cggcaatggg     1440

cggttggacg cgctgtgcca tgcgctggag gaggggctcg ggatccgggt cgcgaatctc     1500

acgtacaagg aacatgcgct ggaagtaggg tcgggatcgc gagcggtggc ttacatcagc     1560

gtcgacgacg aagaagggaa tacccacttc gggtgcggcg tggataccga cattatggag     1620

gcgtcggcga aggcgctggt gagcgcggtc aatcgaatgc tggcgcacag ggcggagatg     1680

gcggtgcccg tgagcaaatg a                                               1701


<210>   1445
<211>   1701
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1430

<400>   1445
atggacatga acaacgtgaa caagtacacc cgccagtatt ttctgccgcc tgaaccctgc       60

ttcgactggg ttcacaagga ccatgtggac cgaccgccga tctggtgcag cgtcgacctg      120

cgcgacggaa atcaggcgct catcgttccg atgaatctcg aggagaagct tgcgtacttt      180

caactgctcg tcgagatcgg cttcaaggag atcgaggtcg gtttcccggc cgcatcggac      240

acggaattcg agttcgtccg gacgctcatc gagcgcgatc tcgtcccgag cgatgtgacc      300

atccaggtcc tcacgcaatc gcgcgatcac atcatcgaac gcacttttga agccattcgc      360

ggggccaagc gggccatcgt ccatctctac aactccacgt ccgtggcgca gcgcgagcag      420

gtgttccgcg cggacaagga cgagatcgtg aacattgccg tgaccggcgc cgaacagatc      480

cgcgatctcg cccgcaccac gcccggcaac ttcttcttcc aatattcacc ggagagcttc      540

acgggtacgg agctcgactt cgcgctcgag atctgcaacg cggtgctcga cgtgtggaaa      600

cccacgccgg atcgcaaggt catcatcaac ctgccggcga ccgtcgagct ttcgatgccg      660

cacgtgtacg cgagccagat cgagtacatg ggcaagcgcc tggctcgccg cgatgccatc      720

gtgctgtccg tgcatccgca caacgatcgc ggcacgggtg tcgcggcggc tgaactcgcc      780

atgctcgcgg gcgcggagcg gctggagggc acgctgtttg ggaacgggga gcgcacgggc      840

aacgtggaca tcgtcacgct cgcgctgaac ctgtactcgc acggcatcga tccggggctc      900

gacttctcca acctcccggc catccaggcc cgtgttgagg ctctcaccaa gatgcaggtg      960

agcaggcgtc acccgtacgc gggggaactc gtcttcacgg cgttttcggg atcgcatcaa     1020

gacgcgatcg cgaagggcat gaagtggcgc gaggagaagt cgcctgagca ttggacggtc     1080

ccgtatctgc ccatcgaccc gaaggatatt ggccgcgaat acgaggggga tatcatccgc     1140

atcaacagcc agtctggcaa gggcggcatc ggctacgtgt tggagcaatc gcacggcttc     1200

gatctgcctc caaagatgcg cgagcagctg gggtatgcgg tcaagcgggt gtcggatcgc     1260

gagcagaagg agctgtcggc ggacgagatc gccgagatct tcatgcgcga gtttattaac     1320

cttgggcagc cgctcgatct cgtcgaactg acgggcacgg atgcgagagg gtcgcaccgc     1380

gtgcgcgcca cggtggtctg gcagggcgag accgtcgaga tcgaaggggc cggcaatggg     1440

cggttggacg cgctgtgcca tgcgctggag gaggggctcg ggatccgggt cgcgaatctc     1500

acgtacaagg aacatgcgct ggaagtaggg tcgggatcgc gagcggtggc ttacatcagc     1560

gtcgacgacg aagaagggaa tacccacttc gggtgcggcg tggataccga cattatggag     1620

gcgtcggcga aggcgctggt gagcgcggtc aatcgaatgc tggcgcacag ggcggagatg     1680

gcggtgcccg tgagcaaatg a                                               1701


<210>   1446
<211>   441
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1446
Met Ser Arg Phe Pro Val Cys Val Phe Ile Val Ser Thr Gly Gln Asp 
                5                   10                  15      

Val Val Lys Arg Ala Ala Lys Phe Tyr Pro Asp Arg Trp His Lys Val 
            20                  25                  30          

Gly Arg Arg His Gly Asn Val Cys Pro Val Phe Leu Cys Ala Val Ser 
        35                  40                  45              

Val Gly Gly Gln Arg Arg Thr Asp Ile Val Asn Ile His Glu Tyr Gln 
    50                  55                  60                  

Ala Lys Ala Ile Leu Ala Glu Phe Gly Val Lys Val Pro Arg Gly Lys 
65                  70                  75                  80  

Val Ala Phe Thr Val Glu Glu Ala Val Glu Ala Ala Lys Glu Leu Gly 
                85                  90                  95      

Gly Lys Ala Val Val Lys Ala Gln Ile His Ala Gly Gly Arg Gly Lys 
            100                 105                 110         

Ala Gly Gly Val Lys Val Ser Lys Ser Leu Glu Glu Val Glu Ala Asn 
        115                 120                 125             

Ala Arg Glu Leu Leu Gly Lys Arg Leu Val Thr His Gln Thr Gly Pro 
    130                 135                 140                 

Gln Gly Arg Ile Val Arg Arg Leu Leu Ile Glu Glu Leu Thr Asn Ile 
145                 150                 155                 160 

Gln Lys Glu Tyr Tyr Ile Gly Leu Val Leu Asp Arg Ser Gln Gly Arg 
                165                 170                 175     

Leu Val Met Met Ala Ser Gln Glu Gly Gly Val Glu Ile Glu Glu Val 
            180                 185                 190         

Ala Ala Lys His Pro Glu Lys Ile Phe Arg Glu Thr Ile Asp Pro Leu 
        195                 200                 205             

Thr Gly Leu Thr Pro Phe Gln Ala Asn Asn Leu Ala Tyr Lys Leu Glu 
    210                 215                 220                 

Leu Pro Gln Asp Ala Val Lys Lys Ala Ala Gln Phe Met Met Ala Leu 
225                 230                 235                 240 

Tyr Asn Ala Tyr Val Ala Lys Asp Cys Ser Ile Ala Glu Ile Asn Pro 
                245                 250                 255     

Leu Val Leu Thr Ala Glu Gly Asp Ile Ile Ala Leu Asp Ala Lys Leu 
            260                 265                 270         

Asn Phe Asp Asp Asn Ala Leu Tyr Arg His Pro Glu Ile Val Ser Leu 
        275                 280                 285             

Arg Asp Glu Asp Glu Glu Asp Pro Lys Glu Ile Glu Ala Ser Lys Tyr 
    290                 295                 300                 

Gly Leu Ser Tyr Ile Ala Leu Asp Gly Asn Ile Gly Cys Met Val Asn 
305                 310                 315                 320 

Gly Ala Gly Leu Ala Met Ala Thr Met Asp Thr Ile Lys Tyr Tyr Gly 
                325                 330                 335     

Gly Glu Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Ser Glu Glu 
            340                 345                 350         

Lys Val Thr Ala Ala Phe Lys Ile Ile Leu Ser Asp Pro Lys Val Lys 
        355                 360                 365             

Gly Ile Leu Val Asn Ile Phe Gly Gly Ile Met Lys Cys Asp Val Ile 
    370                 375                 380                 

Ala Asn Gly Val Val Ala Ala Ala Lys Gln Val Gly Leu Asp Lys Pro 
385                 390                 395                 400 

Leu Val Val Arg Leu Glu Gly Thr Asn Val Glu Ala Gly Lys Lys Ile 
                405                 410                 415     

Leu Asn Glu Ser Gly Leu Lys Leu Val Ala Ala Asp Ser Leu Ala Asp 
            420                 425                 430         

Ala Ala Gln Lys Ile Val Ala Leu Val 
        435                 440     

<210>   1447
<211>   1326
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1447
ttgtcaaggt ttcctgtatg cgttttcatc gtctcaaccg gtcaagacgt tgtcaaacgt       60

gccgcgaagt tctatcctga tagatggcac aaggtcggca gacgccatgg caacgtttgt      120

ccggtttttt tgtgcgccgt atccgtaggg ggacaaagga ggacggacat cgtgaacatc      180

cacgagtatc aagcgaaggc cattctggct gaattcggcg tcaaagtccc gcgcggcaaa      240

gtggctttca cggttgaaga ggctgtggaa gcggcaaaag aacttggtgg caaggctgta      300

gtaaaggctc aaattcatgc aggcgggcgc ggcaaggcgg gtggcgtcaa agtctcgaag      360

tccctggagg aggtcgaggc gaacgcccgc gagcttctcg gcaagcggct cgtcacgcac      420

caaacgggac cgcagggccg aattgtacgg cgactgctca tcgaagagct cacgaatatc      480

cagaaggagt actacatagg cctcgttctt gaccgatccc agggacgctt ggtgatgatg      540

gcctcccagg agggcggcgt cgagatcgaa gaggtagctg caaaacaccc ggaaaagatt      600

ttccgtgaga ccattgatcc actgacgggg ctcacgccgt tccaggcgaa caacctcgcg      660

tacaagcttg agctgcctca ggatgcggtg aaaaaggccg ctcaattcat gatggcgctt      720

tacaacgcgt acgtcgcgaa ggattgctcc atcgcggaga tcaatccgct ggtactgaca      780

gcggaaggcg acatcatcgc cctggatgcg aagctcaact tcgacgacaa tgctttgtac      840

cggcatcccg agatcgtcag cctgcgcgac gaggacgaag aagatccgaa ggaaatcgaa      900

gcctcgaaat acggtttgag ttacatcgcg ctggacggca acattggatg catggtgaat      960

ggtgcgggcc tggccatggc cacgatggac accatcaagt attacggcgg agagcctgcg     1020

aacttcctgg acgtcggtgg aggcgccagc gaagagaaag tgacggcggc gttcaaaatc     1080

atcctgtcgg atcctaaagt gaaaggtatc ctcgtcaaca tcttcggcgg catcatgaag     1140

tgcgacgtga tcgcaaacgg cgtggtcgca gcggccaagc aggtcggcct ggacaagccg     1200

ctcgtggtgc gcctcgaggg cacgaacgtc gaagccggaa agaaaatctt gaacgaatcg     1260

ggtctgaagt tggtggcggc tgattcgctc gctgacgctg cccaaaagat cgtggcgctg     1320

gtctga                                                                1326


<210>   1448
<211>   385
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1448
Met Asn Ile His Glu Tyr Gln Ala Lys Glu Ile Leu Arg Ser Tyr Gly 
                5                   10                  15      

Val Ser Val Pro Asn Gly Arg Val Ala Phe Thr Val Asp Glu Ala Val 
            20                  25                  30          

Glu Ala Ala Lys Ala Leu Gly Thr Ser Val Cys Val Val Lys Ala Gln 
        35                  40                  45              

Ile His Ala Gly Gly Arg Gly Lys Ala Gly Gly Val Lys Val Ala Lys 
    50                  55                  60                  

Ser Leu Glu Glu Val Arg Thr Tyr Ala Ser Glu Leu Leu Gly Lys Val 
65                  70                  75                  80  

Leu Val Thr His Gln Thr Gly Pro Glu Gly Lys Glu Val Lys Arg Leu 
                85                  90                  95      

Leu Ile Glu Glu Gly Cys Asp Ile Gln Lys Glu Tyr Tyr Ile Gly Leu 
            100                 105                 110         

Val Val Asp Arg Ala Thr Ser Arg Val Val Leu Met Gly Ser Glu Glu 
        115                 120                 125             

Gly Gly Thr Glu Ile Glu Glu Val Ala Ala Lys Thr Pro Glu Lys Ile 
    130                 135                 140                 

Phe Lys Glu Tyr Val Asp Pro Ala Val Gly Leu Gln Ala Phe Gln Ala 
145                 150                 155                 160 

Arg Arg Leu Ala Phe Asn Ile Asn Ile Pro Lys Lys Leu Val Asn Gln 
                165                 170                 175     

Ala Val Lys Phe Met Met Gly Leu Tyr Gln Val Phe Val Asp Lys Asp 
            180                 185                 190         

Cys Ser Ile Ala Glu Ile Asn Pro Leu Val Val Thr Gly Asp Gly Lys 
        195                 200                 205             

Val Met Ala Leu Asp Ala Lys Leu Asn Phe Asp Ser Asn Ala Leu Tyr 
    210                 215                 220                 

Arg His Pro Asp Ile Met Glu Tyr Arg Asp Leu Asp Glu Glu Asp Pro 
225                 230                 235                 240 

Lys Glu Val Glu Ala Ser Lys Tyr Asp Leu Asn Tyr Ile Ala Leu Asp 
                245                 250                 255     

Gly Asn Ile Gly Cys Met Val Asn Gly Ala Gly Leu Ala Met Ala Thr 
            260                 265                 270         

Met Asp Ile Ile Lys Tyr Tyr Gly Gly Glu Pro Ala Asn Phe Leu Asp 
        275                 280                 285             

Val Gly Gly Gly Ala Ser Glu Glu Lys Val Thr Glu Ala Phe Lys Ile 
    290                 295                 300                 

Ile Leu Ser Asp Pro Asn Val Lys Gly Ile Phe Val Asn Ile Phe Gly 
305                 310                 315                 320 

Gly Ile Met Lys Cys Asp Val Ile Ala Ser Gly Ile Val Ala Ala Thr 
                325                 330                 335     

Lys Gln Val Gly Leu Thr Leu Pro Leu Val Val Arg Leu Glu Gly Thr 
            340                 345                 350         

Asn Val Glu Leu Gly Lys Lys Ile Leu Gln Glu Ser Gly Leu Asn Ile 
        355                 360                 365             

Thr Ala Ala Glu Ser Met Ala Asp Gly Ala Gln Lys Ile Val Glu Leu 
    370                 375                 380                 

Val 
385 

<210>   1449
<211>   385
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1449
Met Asn Ile His Glu Tyr Gln Ala Lys Glu Ile Leu Arg Ser Tyr Gly 
                5                   10                  15      

Val Ser Val Pro Asn Gly Arg Val Ala Phe Thr Val Asp Glu Ala Val 
            20                  25                  30          

Glu Ala Ala Lys Glu Leu Gly Ala Pro Val Cys Val Val Lys Ala Gln 
        35                  40                  45              

Ile His Ala Gly Gly Arg Gly Lys Ala Gly Gly Val Lys Val Ala Lys 
    50                  55                  60                  

Ser Leu Glu Glu Val Arg Thr Tyr Ala Ser Glu Leu Leu Gly Lys Val 
65                  70                  75                  80  

Leu Val Thr His Gln Thr Gly Pro Glu Gly Lys Glu Val Lys Arg Leu 
                85                  90                  95      

Leu Ile Glu Glu Gly Cys Asp Ile Gln Lys Glu Tyr Tyr Ile Gly Leu 
            100                 105                 110         

Val Val Asp Arg Ala Thr Ser Arg Val Val Leu Met Gly Ser Glu Glu 
        115                 120                 125             

Gly Gly Thr Glu Ile Glu Glu Val Ala Ala Lys Thr Pro Glu Lys Ile 
    130                 135                 140                 

Phe Lys Glu Tyr Ile Asp Pro Ala Val Gly Leu Gln Ala Phe Gln Ala 
145                 150                 155                 160 

Arg Arg Leu Ala Phe Asn Ile Asn Ile Pro Lys His Leu Val Asn Gln 
                165                 170                 175     

Ala Val Lys Phe Met Met Gly Leu Tyr Gln Val Phe Val Asp Lys Asp 
            180                 185                 190         

Cys Ser Ile Ala Glu Ile Asn Pro Leu Val Val Thr Gly Asp Gly Lys 
        195                 200                 205             

Val Met Ala Leu Asp Ala Lys Leu Asn Phe Asp Ser Asn Ala Leu Tyr 
    210                 215                 220                 

Arg His Pro Asp Ile Leu Glu Tyr Arg Asp Leu Asp Glu Glu Asp Pro 
225                 230                 235                 240 

Lys Glu Val Glu Ala Ser Lys Tyr Asp Leu Asn Tyr Ile Ala Leu Asp 
                245                 250                 255     

Gly Asn Ile Gly Cys Met Val Asn Gly Ala Gly Leu Ala Met Ala Thr 
            260                 265                 270         

Met Asp Ile Ile Lys Tyr Tyr Gly Gly Glu Pro Ala Asn Phe Leu Asp 
        275                 280                 285             

Val Gly Gly Gly Ala Ser Glu Glu Lys Val Arg Glu Ala Phe Lys Ile 
    290                 295                 300                 

Ile Leu Ser Asp Pro Asn Val Lys Gly Ile Phe Val Asn Ile Phe Gly 
305                 310                 315                 320 

Gly Ile Met Lys Cys Asp Val Ile Ala Ser Gly Ile Val Ala Ala Thr 
                325                 330                 335     

Lys Gln Val Gly Leu Thr Leu Pro Leu Val Val Arg Leu Glu Gly Thr 
            340                 345                 350         

Asn Val Glu Leu Gly Lys Lys Ile Leu Gln Glu Ser Gly Leu Asn Ile 
        355                 360                 365             

Ile Ala Ala Glu Ser Met Ala Asp Gly Ala Gln Lys Ile Val Glu Leu 
    370                 375                 380                 

Val 
385 

<210>   1450
<211>   385
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   1450
Met Asn Ile His Glu Tyr Gln Gly Lys Glu Val Leu Arg Lys Tyr Gly 
                5                   10                  15      

Val Thr Val Pro Asn Gly Lys Val Ala Phe Thr Val Glu Glu Ala Val 
            20                  25                  30          

Glu Ala Ala Lys Glu Leu Gly Thr Glu Val Val Val Val Lys Ala Gln 
        35                  40                  45              

Ile His Ala Gly Gly Arg Gly Lys Ala Gly Gly Val Lys Val Ala Lys 
    50                  55                  60                  

Asn Leu Asp Glu Val Arg Thr Tyr Ala Ser Glu Ile Leu Gly Lys Thr 
65                  70                  75                  80  

Leu Val Thr His Gln Thr Gly Pro Glu Gly Lys Glu Val Lys Arg Leu 
                85                  90                  95      

Leu Ile Glu Glu Gly Cys Asp Ile Gln Lys Glu Tyr Tyr Val Gly Leu 
            100                 105                 110         

Val Leu Asp Arg Ala Thr Ser Arg Val Val Leu Met Ala Ser Glu Glu 
        115                 120                 125             

Gly Gly Thr Glu Ile Glu Glu Val Ala Glu Lys Thr Pro Glu Lys Ile 
    130                 135                 140                 

Phe Lys Glu Glu Ile Asp Pro Val Ile Gly Leu Thr Ala Phe Gln Ala 
145                 150                 155                 160 

Arg Arg Ile Ala Phe Asn Ile Asn Ile Pro Gly Lys Leu Val Asn Gln 
                165                 170                 175     

Ala Ala Lys Phe Met Leu Ala Leu Tyr Asn Ala Tyr Ile Glu Lys Asp 
            180                 185                 190         

Cys Ser Ile Ala Glu Ile Asn Pro Leu Val Val Thr Gly Asp Gly Lys 
        195                 200                 205             

Val Met Ala Leu Asp Ala Lys Leu Asn Phe Asp Ser Asn Ala Leu Tyr 
    210                 215                 220                 

Arg Gln Lys Asp Ile Leu Glu Tyr Arg Asp Leu Glu Glu Glu Asp Pro 
225                 230                 235                 240 

Lys Glu Ile Glu Ala Ser Lys Tyr Asp Leu Ser Tyr Ile Ser Leu Asp 
                245                 250                 255     

Gly Asn Ile Gly Cys Met Val Asn Gly Ala Gly Leu Ala Met Ala Thr 
            260                 265                 270         

Met Asp Ile Val Lys His Tyr Gly Gly Asp Pro Ala Asn Phe Leu Asp 
        275                 280                 285             

Val Gly Gly Gly Ala Thr Ala Glu Lys Val Thr Glu Ala Phe Lys Ile 
    290                 295                 300                 

Ile Leu Ser Asp Pro Asn Val Lys Gly Ile Phe Val Asn Ile Phe Gly 
305                 310                 315                 320 

Gly Ile Met Lys Cys Asp Val Ile Ala Glu Gly Val Val Glu Ala Ala 
                325                 330                 335     

Lys Gln Val Gly Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr 
            340                 345                 350         

Asn Val Asp Leu Gly Lys Lys Ile Leu Ala Glu Ser Asp Ile Asp Ile 
        355                 360                 365             

Ile Ala Ala Asp Ser Met Ser Asp Gly Ala Glu Lys Ile Val Ser Leu 
    370                 375                 380                 

Val 
385 

<210>   1451
<211>   385
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   1451
Met Asn Ile His Glu Tyr Gln Gly Lys Gln Val Leu Arg Glu Tyr Gly 
                5                   10                  15      

Val Lys Val Pro Asn Gly Tyr Val Ala Tyr Thr Val Asp Glu Ala Val 
            20                  25                  30          

Gln Ala Ala Glu Lys Leu Gly Thr Ser Val Asn Val Val Lys Ala Gln 
        35                  40                  45              

Ile His Ala Gly Gly Arg Gly Lys Ala Gly Gly Val Lys Val Ala Lys 
    50                  55                  60                  

Ser Leu Asp Glu Val Arg Thr Tyr Ala Asp Glu Ile Leu Gly Lys Thr 
65                  70                  75                  80  

Leu Val Thr His Gln Thr Gly Pro Glu Gly Lys Glu Val Lys Arg Leu 
                85                  90                  95      

Leu Ile Glu Glu Gly Cys Asp Ile Gln Lys Glu Tyr Tyr Val Gly Val 
            100                 105                 110         

Val Leu Asp Arg Ala Thr Ser Arg Val Val Met Met Ala Ser Glu Glu 
        115                 120                 125             

Gly Gly Thr Glu Ile Glu Glu Val Ala Glu Ala Thr Pro Glu Lys Ile 
    130                 135                 140                 

Phe Lys Glu Val Ile Asp Pro Val Val Gly Leu Thr Pro Phe Gln Ala 
145                 150                 155                 160 

Arg Arg Leu Ala Phe Asn Ile Asn Ile Pro Glu Asp Leu Leu Gly Lys 
                165                 170                 175     

Ala Val Lys Phe Met Ser Gly Leu Tyr Asp Ala Phe Val Ala Lys Asp 
            180                 185                 190         

Cys Ser Ile Ala Glu Ile Asn Pro Leu Val Thr Thr Gly Asp Gly Glu 
        195                 200                 205             

Val Leu Ala Leu Asp Ala Lys Leu Asn Phe Asp Asp Asn Ala Leu Tyr 
    210                 215                 220                 

Arg His Lys Asp Ile Gln Asp Leu Arg Asp Phe Glu Glu Glu Asp Glu 
225                 230                 235                 240 

Lys Glu Ile Gln Ala Ser Lys Tyr Asp Leu Ser Tyr Val Ser Leu Asp 
                245                 250                 255     

Gly Asn Ile Gly Cys Met Val Asn Gly Ala Gly Leu Ala Met Ser Thr 
            260                 265                 270         

Met Asp Ile Ile Lys His Tyr Gly Gly Asp Pro Ala Asn Phe Leu Asp 
        275                 280                 285             

Val Gly Gly Gly Ala Thr Ala Glu Lys Val Thr Glu Ala Phe Lys Ile 
    290                 295                 300                 

Ile Leu Ser Asp Lys Asn Val Lys Gly Ile Phe Val Asn Ile Phe Gly 
305                 310                 315                 320 

Gly Ile Met Lys Cys Asp Val Ile Ala Glu Gly Val Val Glu Ala Thr 
                325                 330                 335     

Lys Gln Ile Gly Leu Glu Ile Pro Leu Val Val Arg Leu Glu Gly Thr 
            340                 345                 350         

Asn Val Asp Ala Gly Lys Lys Ile Leu Asp Glu Ser Gly Leu Asn Ile 
        355                 360                 365             

Thr Thr Ala Thr Ser Met Ala Asp Gly Ala Glu Lys Ile Val Ala Ala 
    370                 375                 380                 

Val 
385 

<210>   1452
<211>   385
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   1452
Met Asn Ile His Glu Tyr Gln Gly Lys Ala Ile Leu Arg Ser Tyr Gly 
                5                   10                  15      

Val Ser Val Pro Asn Gly Lys Val Ala Phe Thr Val Glu Glu Ala Val 
            20                  25                  30          

Glu Ala Ala Lys Glu Leu Gly Thr Asp Val Cys Val Val Lys Ala Gln 
        35                  40                  45              

Ile His Ala Gly Gly Arg Gly Lys Ala Gly Gly Val Lys Val Ala Lys 
    50                  55                  60                  

Asn Leu Glu Glu Val Arg Thr Tyr Ala Glu Asn Ile Leu Gly Ser Thr 
65                  70                  75                  80  

Leu Val Thr His Gln Thr Gly Pro Glu Gly Lys Glu Val Lys Arg Leu 
                85                  90                  95      

Leu Ile Glu Glu Gly Cys Asp Ile Lys Lys Glu Tyr Tyr Val Gly Leu 
            100                 105                 110         

Val Leu Asp Arg Ala Thr Ser Gln Val Val Leu Met Ala Ser Glu Glu 
        115                 120                 125             

Gly Gly Thr Glu Ile Glu Glu Val Ala Glu Lys Thr Pro Glu Lys Ile 
    130                 135                 140                 

Phe Lys Glu Tyr Ile Asp Pro Ala Val Gly Leu Gln Gly Phe Gln Ala 
145                 150                 155                 160 

Arg Arg Ile Ala Phe His Ile Asn Ile Pro Lys Glu Leu Val Gly Gln 
                165                 170                 175     

Ala Val Lys Phe Met Met Gly Leu Tyr Arg Val Phe Ile Glu Lys Asp 
            180                 185                 190         

Cys Ser Ile Ala Glu Ile Asn Pro Leu Val Thr Thr Gly Asp Gly Lys 
        195                 200                 205             

Val Met Ala Leu Asp Ala Lys Leu Asn Phe Asp Ser Asn Ala Leu Tyr 
    210                 215                 220                 

Arg His Lys Asp Ile Leu Glu Leu Arg Asp Leu Asp Glu Glu Asp Pro 
225                 230                 235                 240 

Lys Glu Ile Glu Ala Ser Lys Tyr Asp Leu Asn Tyr Ile Pro Leu Asp 
                245                 250                 255     

Gly Asn Ile Gly Cys Met Val Asn Gly Ala Gly Leu Ala Met Ala Thr 
            260                 265                 270         

Met Asp Ile Ile Lys His Tyr His Gly Asp Pro Ala Asn Phe Leu Asp 
        275                 280                 285             

Val Gly Gly Gly Ala Thr Ala Glu Lys Val Thr Glu Ala Phe Lys Ile 
    290                 295                 300                 

Ile Leu Ser Asp Lys Asn Val Lys Gly Ile Phe Val Asn Ile Phe Gly 
305                 310                 315                 320 

Gly Ile Met Lys Cys Asp Val Ile Ala Glu Gly Val Val Glu Ala Thr 
                325                 330                 335     

Lys Gln Val Gly Leu Glu Leu Pro Leu Val Val Arg Leu Glu Gly Thr 
            340                 345                 350         

Asn Val Glu Leu Gly Lys Lys Ile Leu Asn Glu Ser Gly Leu Asn Ile 
        355                 360                 365             

Val Ala Ala Glu Ser Met Ala Asp Gly Ala Gln Lys Ile Val Ser Leu 
    370                 375                 380                 

Val 
385 

<210>   1453
<211>   441
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1446

<400>   1453
Met Ser Arg Phe Pro Val Cys Val Phe Ile Val Ser Thr Gly Gln Asp 
                5                   10                  15      

Val Val Lys Lys Ala Ala Lys Phe Tyr Pro Asp Arg Trp His Lys Val 
            20                  25                  30          

Gly Arg Arg His Gly Asn Val Cys Pro Val Phe Leu Cys Ala Val Ser 
        35                  40                  45              

Val Gly Gly Gln Arg Arg Thr Asp Ile Val Asn Ile His Glu Tyr Gln 
    50                  55                  60                  

Ala Lys Ala Ile Leu Ala Glu Phe Gly Val Lys Val Pro Arg Gly Lys 
65                  70                  75                  80  

Val Ala Phe Thr Val Glu Glu Ala Val Glu Ala Ala Lys Glu Leu Gly 
                85                  90                  95      

Gly Lys Ala Val Val Lys Ala Gln Ile His Ala Gly Gly Arg Gly Lys 
            100                 105                 110         

Ala Gly Gly Val Lys Val Ser Lys Ser Leu Glu Glu Val Glu Ala Asn 
        115                 120                 125             

Ala Arg Glu Leu Leu Gly Lys Arg Leu Val Thr His Gln Thr Gly Pro 
    130                 135                 140                 

Gln Gly Arg Ile Val Arg Arg Leu Leu Ile Glu Glu Leu Thr Asn Ile 
145                 150                 155                 160 

Gln Lys Glu Tyr Tyr Ile Gly Leu Val Leu Asp Arg Ser Gln Gly Arg 
                165                 170                 175     

Leu Val Met Met Ala Ser Gln Glu Gly Gly Val Glu Ile Glu Glu Val 
            180                 185                 190         

Ala Ala Lys His Pro Glu Lys Ile Phe Arg Glu Thr Ile Asp Pro Leu 
        195                 200                 205             

Thr Gly Leu Thr Pro Phe Gln Ala Asn Asn Leu Ala Tyr Lys Leu Glu 
    210                 215                 220                 

Leu Pro Gln Asp Ala Val Lys Lys Ala Ala Gln Phe Met Met Ala Leu 
225                 230                 235                 240 

Tyr Asn Ala Tyr Val Ala Lys Asp Cys Ser Ile Ala Glu Ile Asn Pro 
                245                 250                 255     

Leu Val Leu Thr Ala Glu Gly Asp Ile Ile Ala Leu Asp Ala Lys Leu 
            260                 265                 270         

Asn Phe Asp Asp Asn Ala Leu Tyr Arg His Pro Glu Ile Val Ser Leu 
        275                 280                 285             

Arg Asp Glu Asp Glu Glu Asp Pro Lys Glu Ile Glu Ala Ser Lys Tyr 
    290                 295                 300                 

Gly Leu Ser Tyr Ile Ala Leu Asp Gly Asn Ile Gly Cys Met Val Asn 
305                 310                 315                 320 

Gly Ala Gly Leu Ala Met Ala Thr Met Asp Thr Ile Lys Tyr Tyr Gly 
                325                 330                 335     

Gly Glu Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Ser Glu Glu 
            340                 345                 350         

Lys Val Thr Ala Ala Phe Lys Ile Ile Leu Ser Asp Pro Lys Val Lys 
        355                 360                 365             

Gly Ile Leu Val Asn Ile Phe Gly Gly Ile Met Lys Cys Asp Val Ile 
    370                 375                 380                 

Ala Asn Gly Val Val Ala Ala Ala Lys Gln Val Gly Leu Asp Lys Pro 
385                 390                 395                 400 

Leu Val Val Arg Leu Glu Gly Thr Asn Val Glu Ala Gly Lys Lys Ile 
                405                 410                 415     

Leu Asn Glu Ser Gly Leu Lys Leu Val Ala Ala Asp Ser Leu Ala Asp 
            420                 425                 430         

Ala Ala Gln Lys Ile Val Ala Leu Val 
        435                 440     

<210>   1454
<211>   441
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1446

<400>   1454
Met Ser Arg Phe Pro Val Cys Val Phe Ile Val Ser Thr Gly Gln Asp 
                5                   10                  15      

Val Val Lys Arg Ala Ala Lys Phe Tyr Pro Asp Arg Trp His Lys Val 
            20                  25                  30          

Gly Arg Arg His Gly Asn Val Cys Pro Val Phe Leu Cys Ala Val Ser 
        35                  40                  45              

Val Gly Gly Gln Arg Arg Thr Asp Ile Val Asn Ile His Glu Tyr Gln 
    50                  55                  60                  

Ala Lys Ala Ile Leu Ala Glu Phe Gly Val Lys Val Pro Arg Gly Lys 
65                  70                  75                  80  

Val Ala Phe Thr Val Glu Glu Ala Val Glu Ala Ala Lys Glu Leu Gly 
                85                  90                  95      

Gly Lys Ala Val Val Lys Ala Gln Ile His Ala Gly Gly Arg Gly Lys 
            100                 105                 110         

Ala Gly Gly Val Lys Val Ser Lys Ser Leu Glu Glu Val Glu Ala Asn 
        115                 120                 125             

Ala Arg Glu Leu Leu Gly Lys Arg Leu Val Thr His Gln Thr Gly Pro 
    130                 135                 140                 

Gln Gly Arg Ile Val Arg Arg Leu Leu Ile Glu Glu Leu Thr Asn Ile 
145                 150                 155                 160 

Gln Lys Glu Tyr Tyr Ile Gly Leu Val Leu Asp Arg Ser Gln Gly Arg 
                165                 170                 175     

Leu Val Met Met Ala Ser Gln Glu Gly Gly Val Glu Ile Glu Glu Val 
            180                 185                 190         

Ala Ala Lys His Pro Glu Lys Ile Phe Arg Glu Thr Ile Asp Pro Leu 
        195                 200                 205             

Thr Gly Leu Thr Pro Phe Gln Ala Asn Asn Leu Ala Tyr Lys Leu Glu 
    210                 215                 220                 

Leu Pro Gln Asp Ala Val Lys Lys Ala Ala Gln Phe Met Met Ala Leu 
225                 230                 235                 240 

Tyr Asn Ala Tyr Val Ala Lys Asp Cys Ser Ile Ala Glu Ile Asn Pro 
                245                 250                 255     

Leu Val Leu Thr Ala Glu Gly Asp Ile Ile Ala Leu Asp Ala Lys Leu 
            260                 265                 270         

Asn Phe Asp Asp Asn Ala Leu Tyr Arg His Pro Glu Ile Val Ser Leu 
        275                 280                 285             

Arg Asp Glu Asp Glu Glu Asp Pro Lys Glu Ile Glu Ala Ser Lys Tyr 
    290                 295                 300                 

Gly Leu Ser Tyr Ile Ala Leu Asp Gly Asn Ile Gly Cys Met Val Asn 
305                 310                 315                 320 

Gly Ala Gly Leu Ala Met Ala Thr Met Asp Thr Ile Lys Tyr Tyr Gly 
                325                 330                 335     

Gly Glu Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Ser Glu Glu 
            340                 345                 350         

Lys Val Thr Ala Ala Phe Lys Ile Ile Leu Ser Asp Pro Lys Val Lys 
        355                 360                 365             

Gly Ile Leu Val Asn Ile Phe Gly Gly Ile Met Lys Cys Asp Val Ile 
    370                 375                 380                 

Ala Asn Gly Val Val Ala Ala Ala Lys Gln Val Gly Leu Asp Lys Pro 
385                 390                 395                 400 

Leu Val Val Arg Leu Glu Gly Thr Asn Val Glu Ala Gly Lys Lys Ile 
                405                 410                 415     

Leu Asn Glu Ser Gly Leu Lys Leu Ile Ala Ala Asp Ser Leu Ala Asp 
            420                 425                 430         

Ala Ala Gln Lys Ile Val Ala Leu Val 
        435                 440     

<210>   1455
<211>   441
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1446

<400>   1455
Met Ser Arg Phe Pro Val Cys Val Phe Ile Val Ser Thr Gly Gln Asp 
                5                   10                  15      

Val Val Lys Arg Ala Ala Lys Phe Tyr Pro Asp Arg Trp His Lys Val 
            20                  25                  30          

Gly Arg Arg His Gly Asn Val Cys Pro Val Phe Leu Cys Ala Val Ser 
        35                  40                  45              

Val Gly Gly Gln Arg Arg Thr Asp Ile Val Asn Ile His Glu Tyr Gln 
    50                  55                  60                  

Ala Lys Ala Ile Leu Ala Glu Phe Gly Val Lys Val Pro Arg Gly Lys 
65                  70                  75                  80  

Val Ala Phe Thr Val Glu Glu Ala Val Glu Ala Ala Lys Glu Leu Gly 
                85                  90                  95      

Gly Lys Ala Val Val Lys Ala Gln Ile His Ala Gly Gly Arg Gly Lys 
            100                 105                 110         

Ala Gly Gly Val Lys Val Ser Lys Ser Leu Glu Glu Val Glu Ala Asn 
        115                 120                 125             

Ala Arg Glu Leu Leu Gly Lys Arg Leu Val Thr His Gln Thr Gly Pro 
    130                 135                 140                 

Gln Gly Arg Ile Val Arg Arg Leu Leu Ile Glu Glu Leu Thr Asn Ile 
145                 150                 155                 160 

Gln Lys Glu Tyr Tyr Ile Gly Leu Val Leu Asp Arg Ser Gln Gly Arg 
                165                 170                 175     

Leu Val Met Met Ala Ser Gln Glu Gly Gly Val Glu Ile Glu Glu Val 
            180                 185                 190         

Ala Ala Lys His Pro Glu Lys Ile Phe Arg Glu Thr Ile Asp Pro Leu 
        195                 200                 205             

Thr Gly Leu Thr Pro Phe Gln Ala Asn Asn Leu Ala Tyr Lys Leu Glu 
    210                 215                 220                 

Leu Pro Gln Asp Ala Val Lys Lys Ala Ala Gln Phe Met Met Ala Leu 
225                 230                 235                 240 

Tyr Asn Ala Tyr Val Ala Lys Asp Cys Ser Ile Ala Glu Ile Asn Pro 
                245                 250                 255     

Leu Val Leu Thr Ala Glu Gly Asp Ile Ile Ala Leu Asp Ala Lys Leu 
            260                 265                 270         

Asn Phe Asp Asp Asn Ala Leu Tyr Arg His Pro Glu Ile Val Ser Ile 
        275                 280                 285             

Arg Asp Glu Asp Glu Glu Asp Pro Lys Glu Ile Glu Ala Ser Lys Tyr 
    290                 295                 300                 

Gly Leu Ser Tyr Ile Ala Leu Asp Gly Asn Ile Gly Cys Met Val Asn 
305                 310                 315                 320 

Gly Ala Gly Leu Ala Met Ala Thr Met Asp Thr Ile Lys Tyr Tyr Gly 
                325                 330                 335     

Gly Glu Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Ser Glu Glu 
            340                 345                 350         

Lys Val Thr Ala Ala Phe Lys Ile Ile Leu Ser Asp Pro Lys Val Lys 
        355                 360                 365             

Gly Ile Leu Val Asn Ile Phe Gly Gly Ile Met Lys Cys Asp Val Ile 
    370                 375                 380                 

Ala Asn Gly Val Val Ala Ala Ala Lys Gln Val Gly Leu Asp Lys Pro 
385                 390                 395                 400 

Leu Val Val Arg Leu Glu Gly Thr Asn Val Glu Ala Gly Lys Lys Ile 
                405                 410                 415     

Leu Asn Glu Ser Gly Leu Lys Leu Val Ala Ala Asp Ser Leu Ala Asp 
            420                 425                 430         

Ala Ala Gln Lys Ile Val Ala Leu Val 
        435                 440     

<210>   1456
<211>   441
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1446

<400>   1456
Met Ser Arg Phe Pro Val Cys Val Phe Ile Val Ser Thr Gly Gln Asp 
                5                   10                  15      

Val Val Lys Arg Ala Ala Lys Phe Tyr Pro Asp Arg Trp His Lys Val 
            20                  25                  30          

Gly Arg Arg His Gly Asn Val Cys Pro Val Phe Leu Cys Ala Val Ser 
        35                  40                  45              

Val Gly Gly Gln Arg Arg Thr Asp Ile Val Asn Ile His Glu Tyr Gln 
    50                  55                  60                  

Ala Lys Ala Ile Leu Ala Glu Phe Gly Val Lys Val Pro Arg Gly Lys 
65                  70                  75                  80  

Val Ala Phe Thr Val Glu Glu Ala Val Glu Ala Ala Lys Glu Leu Gly 
                85                  90                  95      

Gly Lys Ala Val Val Lys Ala Gln Ile His Ala Gly Gly Arg Gly Lys 
            100                 105                 110         

Ala Gly Gly Val Lys Val Ser Lys Ser Leu Glu Glu Val Glu Ala Asn 
        115                 120                 125             

Ala Arg Glu Leu Leu Gly Lys Arg Leu Val Thr His Gln Thr Gly Pro 
    130                 135                 140                 

Gln Gly Arg Ile Val Arg Arg Leu Leu Ile Glu Glu Leu Thr Asn Ile 
145                 150                 155                 160 

Gln Lys Glu Tyr Tyr Ile Gly Leu Val Leu Asp Arg Ser Gln Gly Arg 
                165                 170                 175     

Leu Val Met Met Ala Ser Gln Glu Gly Gly Val Glu Ile Glu Glu Val 
            180                 185                 190         

Ala Ala Lys His Pro Glu Lys Ile Phe Arg Glu Thr Ile Asp Pro Leu 
        195                 200                 205             

Thr Gly Leu Thr Pro Phe Gln Ala Asn Asn Leu Ala Tyr Lys Leu Glu 
    210                 215                 220                 

Leu Pro Gln Asp Ala Val Lys Lys Ala Ala Gln Phe Met Met Ala Leu 
225                 230                 235                 240 

Tyr Asn Ala Tyr Val Ala Lys Asp Cys Ser Ile Ala Glu Ile Asn Pro 
                245                 250                 255     

Leu Val Leu Thr Ala Glu Gly Asp Ile Ile Ala Leu Asp Ala Lys Leu 
            260                 265                 270         

Asn Phe Asp Asp Asn Ala Leu Tyr Arg His Pro Glu Ile Val Ser Leu 
        275                 280                 285             

Arg Asp Glu Asp Glu Glu Asp Pro Lys Glu Ile Glu Ala Ser Lys Tyr 
    290                 295                 300                 

Gly Leu Ser Tyr Ile Ala Leu Asp Gly Asn Ile Gly Cys Met Val Asn 
305                 310                 315                 320 

Gly Ala Gly Leu Ala Met Ala Thr Met Asp Thr Ile Lys Tyr Tyr Gly 
                325                 330                 335     

Gly Glu Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Ser Glu Glu 
            340                 345                 350         

Lys Val Thr Ala Ala Phe Lys Ile Ile Leu Ser Asp Pro Lys Val Lys 
        355                 360                 365             

Gly Ile Leu Val Asn Ile Phe Gly Gly Ile Met Lys Cys Asp Val Ile 
    370                 375                 380                 

Ala Asn Gly Val Val Ala Ala Ala Lys Gln Val Gly Leu Asp Lys Pro 
385                 390                 395                 400 

Leu Val Val Arg Leu Glu Gly Thr Asn Val Glu Ala Gly Lys Lys Ile 
                405                 410                 415     

Leu Asn Glu Ser Gly Leu Lys Leu Val Ala Ala Glu Ser Leu Ala Asp 
            420                 425                 430         

Ala Ala Gln Lys Ile Val Ala Leu Val 
        435                 440     

<210>   1457
<211>   441
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1446

<400>   1457
Met Ser Arg Phe Pro Val Cys Val Phe Ile Val Ser Thr Gly Gln Asp 
                5                   10                  15      

Val Val Lys Arg Ala Ala Lys Phe Tyr Pro Asp Arg Trp His Lys Val 
            20                  25                  30          

Gly Lys Arg His Gly Asn Val Cys Pro Val Phe Leu Cys Ala Val Ser 
        35                  40                  45              

Val Gly Gly Gln Arg Arg Thr Asp Ile Val Asn Ile His Glu Tyr Gln 
    50                  55                  60                  

Ala Lys Ala Ile Leu Ala Glu Phe Gly Val Lys Val Pro Arg Gly Lys 
65                  70                  75                  80  

Val Ala Phe Thr Val Glu Glu Ala Val Glu Ala Ala Lys Glu Leu Gly 
                85                  90                  95      

Gly Lys Ala Val Val Lys Ala Gln Ile His Ala Gly Gly Arg Gly Lys 
            100                 105                 110         

Ala Gly Gly Val Lys Val Ser Lys Ser Leu Glu Glu Val Glu Ala Asn 
        115                 120                 125             

Ala Arg Glu Leu Leu Gly Lys Arg Leu Val Thr His Gln Thr Gly Pro 
    130                 135                 140                 

Gln Gly Arg Ile Val Arg Arg Leu Leu Ile Glu Glu Leu Thr Asn Ile 
145                 150                 155                 160 

Gln Lys Glu Tyr Tyr Ile Gly Leu Val Leu Asp Arg Ser Gln Gly Arg 
                165                 170                 175     

Leu Val Met Met Ala Ser Gln Glu Gly Gly Val Glu Ile Glu Glu Val 
            180                 185                 190         

Ala Ala Lys His Pro Glu Lys Ile Phe Arg Glu Thr Ile Asp Pro Leu 
        195                 200                 205             

Thr Gly Leu Thr Pro Phe Gln Ala Asn Asn Leu Ala Tyr Lys Leu Glu 
    210                 215                 220                 

Leu Pro Gln Asp Ala Val Lys Lys Ala Ala Gln Phe Met Met Ala Leu 
225                 230                 235                 240 

Tyr Asn Ala Tyr Val Ala Lys Asp Cys Ser Ile Ala Glu Ile Asn Pro 
                245                 250                 255     

Leu Val Leu Thr Ala Glu Gly Asp Ile Ile Ala Leu Asp Ala Lys Leu 
            260                 265                 270         

Asn Phe Asp Asp Asn Ala Leu Tyr Arg His Pro Glu Ile Val Ser Leu 
        275                 280                 285             

Arg Asp Glu Asp Glu Glu Asp Pro Lys Glu Ile Glu Ala Ser Lys Tyr 
    290                 295                 300                 

Gly Leu Ser Tyr Ile Ala Leu Asp Gly Asn Ile Gly Cys Met Val Asn 
305                 310                 315                 320 

Gly Ala Gly Leu Ala Met Ala Thr Met Asp Thr Ile Lys Tyr Tyr Gly 
                325                 330                 335     

Gly Glu Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Ser Glu Glu 
            340                 345                 350         

Lys Val Thr Ala Ala Phe Lys Ile Ile Leu Ser Asp Pro Lys Val Lys 
        355                 360                 365             

Gly Ile Leu Val Asn Ile Phe Gly Gly Ile Met Lys Cys Asp Val Ile 
    370                 375                 380                 

Ala Asn Gly Val Val Ala Ala Ala Lys Gln Val Gly Leu Asp Lys Pro 
385                 390                 395                 400 

Leu Val Val Arg Leu Glu Gly Thr Asn Val Glu Ala Gly Lys Lys Ile 
                405                 410                 415     

Leu Asn Glu Ser Gly Leu Lys Leu Val Ala Ala Asp Ser Leu Ala Asp 
            420                 425                 430         

Ala Ala Gln Lys Ile Val Ala Leu Val 
        435                 440     

<210>   1458
<211>   1326
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1447

<400>   1458
ttgtcaaggt ttcctgtatg cgttttcatc gtctcaaccg gtcaagacgt tgtcaaaaaa       60

gccgcgaagt tctatcctga tagatggcac aaggtcggca gacgccatgg caacgtttgt      120

ccggtttttt tgtgcgccgt atccgtaggg ggacaaagga ggacggacat cgtgaacatc      180

cacgagtatc aagcgaaggc cattctggct gaattcggcg tcaaagtccc gcgcggcaaa      240

gtggctttca cggttgaaga ggctgtggaa gcggcaaaag aacttggtgg caaggctgta      300

gtaaaggctc aaattcatgc aggcgggcgc ggcaaggcgg gtggcgtcaa agtctcgaag      360

tccctggagg aggtcgaggc gaacgcccgc gagcttctcg gcaagcggct cgtcacgcac      420

caaacgggac cgcagggccg aattgtacgg cgactgctca tcgaagagct cacgaatatc      480

cagaaggagt actacatagg cctcgttctt gaccgatccc agggacgctt ggtgatgatg      540

gcctcccagg agggcggcgt cgagatcgaa gaggtagctg caaaacaccc ggaaaagatt      600

ttccgtgaga ccattgatcc actgacgggg ctcacgccgt tccaggcgaa caacctcgcg      660

tacaagcttg agctgcctca ggatgcggtg aaaaaggccg ctcaattcat gatggcgctt      720

tacaacgcgt acgtcgcgaa ggattgctcc atcgcggaga tcaatccgct ggtactgaca      780

gcggaaggcg acatcatcgc cctggatgcg aagctcaact tcgacgacaa tgctttgtac      840

cggcatcccg agatcgtcag cctgcgcgac gaggacgaag aagatccgaa ggaaatcgaa      900

gcctcgaaat acggtttgag ttacatcgcg ctggacggca acattggatg catggtgaat      960

ggtgcgggcc tggccatggc cacgatggac accatcaagt attacggcgg agagcctgcg     1020

aacttcctgg acgtcggtgg aggcgccagc gaagagaaag tgacggcggc gttcaaaatc     1080

atcctgtcgg atcctaaagt gaaaggtatc ctcgtcaaca tcttcggcgg catcatgaag     1140

tgcgacgtga tcgcaaacgg cgtggtcgca gcggccaagc aggtcggcct ggacaagccg     1200

ctcgtggtgc gcctcgaggg cacgaacgtc gaagccggaa agaaaatctt gaacgaatcg     1260

ggtctgaagt tggtggcggc tgattcgctc gctgacgctg cccaaaagat cgtggcgctg     1320

gtctga                                                                1326


<210>   1459
<211>   1326
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1447

<400>   1459
ttgtcaaggt ttcctgtatg cgttttcatc gtctcaaccg gtcaagacgt tgtcaaacgt       60

gccgcgaagt tctatcctga tagatggcac aaggtcggca gacgccatgg caacgtttgt      120

ccggtttttt tgtgcgccgt atccgtaggg ggacaaagga ggacggacat cgtgaacatc      180

cacgagtatc aagcgaaggc cattctggct gaattcggcg tcaaagtccc gcgcggcaaa      240

gtggctttca cggttgaaga ggctgtggaa gcggcaaaag aacttggtgg caaggctgta      300

gtaaaggctc aaattcatgc aggcgggcgc ggcaaggcgg gtggcgtcaa agtctcgaag      360

tccctggagg aggtcgaggc gaacgcccgc gagcttctcg gcaagcggct cgtcacgcac      420

caaacgggac cgcagggccg aattgtacgg cgactgctca tcgaagagct cacgaatatc      480

cagaaggagt actacatagg cctcgttctt gaccgatccc agggacgctt ggtgatgatg      540

gcctcccagg agggcggcgt cgagatcgaa gaggtagctg caaaacaccc ggaaaagatt      600

ttccgtgaga ccattgatcc actgacgggg ctcacgccgt tccaggcgaa caacctcgcg      660

tacaagcttg agctgcctca ggatgcggtg aaaaaggccg ctcaattcat gatggcgctt      720

tacaacgcgt acgtcgcgaa ggattgctcc atcgcggaga tcaatccgct ggtactgaca      780

gcggaaggcg acatcatcgc cctggatgcg aagctcaact tcgacgacaa tgctttgtac      840

cggcatcccg agatcgtcag cctgcgcgac gaggacgaag aagatccgaa ggaaatcgaa      900

gcctcgaaat acggtttgag ttacatcgcg ctggacggca acattggatg catggtgaat      960

ggtgcgggcc tggccatggc cacgatggac accatcaagt attacggcgg agagcctgcg     1020

aacttcctgg acgtcggtgg aggcgccagc gaagagaaag tgacggcggc gttcaaaatc     1080

atcctgtcgg atcctaaagt gaaaggtatc ctcgtcaaca tcttcggcgg catcatgaag     1140

tgcgacgtga tcgcaaacgg cgtggtcgca gcggccaagc aggtcggcct ggacaagccg     1200

ctcgtggtgc gcctcgaggg cacgaacgtc gaagccggaa agaaaatctt gaacgaatcg     1260

ggtctgaagt tgattgcggc tgattcgctc gctgacgctg cccaaaagat cgtggcgctg     1320

gtctga                                                                1326


<210>   1460
<211>   1326
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1447

<400>   1460
ttgtcaaggt ttcctgtatg cgttttcatc gtctcaaccg gtcaagacgt tgtcaaacgt       60

gccgcgaagt tctatcctga tagatggcac aaggtcggca gacgccatgg caacgtttgt      120

ccggtttttt tgtgcgccgt atccgtaggg ggacaaagga ggacggacat cgtgaacatc      180

cacgagtatc aagcgaaggc cattctggct gaattcggcg tcaaagtccc gcgcggcaaa      240

gtggctttca cggttgaaga ggctgtggaa gcggcaaaag aacttggtgg caaggctgta      300

gtaaaggctc aaattcatgc aggcgggcgc ggcaaggcgg gtggcgtcaa agtctcgaag      360

tccctggagg aggtcgaggc gaacgcccgc gagcttctcg gcaagcggct cgtcacgcac      420

caaacgggac cgcagggccg aattgtacgg cgactgctca tcgaagagct cacgaatatc      480

cagaaggagt actacatagg cctcgttctt gaccgatccc agggacgctt ggtgatgatg      540

gcctcccagg agggcggcgt cgagatcgaa gaggtagctg caaaacaccc ggaaaagatt      600

ttccgtgaga ccattgatcc actgacgggg ctcacgccgt tccaggcgaa caacctcgcg      660

tacaagcttg agctgcctca ggatgcggtg aaaaaggccg ctcaattcat gatggcgctt      720

tacaacgcgt acgtcgcgaa ggattgctcc atcgcggaga tcaatccgct ggtactgaca      780

gcggaaggcg acatcatcgc cctggatgcg aagctcaact tcgacgacaa tgctttgtac      840

cggcatcccg agatcgtcag cattcgcgac gaggacgaag aagatccgaa ggaaatcgaa      900

gcctcgaaat acggtttgag ttacatcgcg ctggacggca acattggatg catggtgaat      960

ggtgcgggcc tggccatggc cacgatggac accatcaagt attacggcgg agagcctgcg     1020

aacttcctgg acgtcggtgg aggcgccagc gaagagaaag tgacggcggc gttcaaaatc     1080

atcctgtcgg atcctaaagt gaaaggtatc ctcgtcaaca tcttcggcgg catcatgaag     1140

tgcgacgtga tcgcaaacgg cgtggtcgca gcggccaagc aggtcggcct ggacaagccg     1200

ctcgtggtgc gcctcgaggg cacgaacgtc gaagccggaa agaaaatctt gaacgaatcg     1260

ggtctgaagt tggtggcggc tgattcgctc gctgacgctg cccaaaagat cgtggcgctg     1320

gtctga                                                                1326


<210>   1461
<211>   1326
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1447

<400>   1461
ttgtcaaggt ttcctgtatg cgttttcatc gtctcaaccg gtcaagacgt tgtcaaacgt       60

gccgcgaagt tctatcctga tagatggcac aaggtcggca gacgccatgg caacgtttgt      120

ccggtttttt tgtgcgccgt atccgtaggg ggacaaagga ggacggacat cgtgaacatc      180

cacgagtatc aagcgaaggc cattctggct gaattcggcg tcaaagtccc gcgcggcaaa      240

gtggctttca cggttgaaga ggctgtggaa gcggcaaaag aacttggtgg caaggctgta      300

gtaaaggctc aaattcatgc aggcgggcgc ggcaaggcgg gtggcgtcaa agtctcgaag      360

tccctggagg aggtcgaggc gaacgcccgc gagcttctcg gcaagcggct cgtcacgcac      420

caaacgggac cgcagggccg aattgtacgg cgactgctca tcgaagagct cacgaatatc      480

cagaaggagt actacatagg cctcgttctt gaccgatccc agggacgctt ggtgatgatg      540

gcctcccagg agggcggcgt cgagatcgaa gaggtagctg caaaacaccc ggaaaagatt      600

ttccgtgaga ccattgatcc actgacgggg ctcacgccgt tccaggcgaa caacctcgcg      660

tacaagcttg agctgcctca ggatgcggtg aaaaaggccg ctcaattcat gatggcgctt      720

tacaacgcgt acgtcgcgaa ggattgctcc atcgcggaga tcaatccgct ggtactgaca      780

gcggaaggcg acatcatcgc cctggatgcg aagctcaact tcgacgacaa tgctttgtac      840

cggcatcccg agatcgtcag cctgcgcgac gaggacgaag aagatccgaa ggaaatcgaa      900

gcctcgaaat acggtttgag ttacatcgcg ctggacggca acattggatg catggtgaat      960

ggtgcgggcc tggccatggc cacgatggac accatcaagt attacggcgg agagcctgcg     1020

aacttcctgg acgtcggtgg aggcgccagc gaagagaaag tgacggcggc gttcaaaatc     1080

atcctgtcgg atcctaaagt gaaaggtatc ctcgtcaaca tcttcggcgg catcatgaag     1140

tgcgacgtga tcgcaaacgg cgtggtcgca gcggccaagc aggtcggcct ggacaagccg     1200

ctcgtggtgc gcctcgaggg cacgaacgtc gaagccggaa agaaaatctt gaacgaatcg     1260

ggtctgaagt tggtggcggc tgaatcgctc gctgacgctg cccaaaagat cgtggcgctg     1320

gtctga                                                                1326


<210>   1462
<211>   1326
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1447

<400>   1462
ttgtcaaggt ttcctgtatg cgttttcatc gtctcaaccg gtcaagacgt tgtcaaacgt       60

gccgcgaagt tctatcctga tagatggcac aaggtcggca aacgccatgg caacgtttgt      120

ccggtttttt tgtgcgccgt atccgtaggg ggacaaagga ggacggacat cgtgaacatc      180

cacgagtatc aagcgaaggc cattctggct gaattcggcg tcaaagtccc gcgcggcaaa      240

gtggctttca cggttgaaga ggctgtggaa gcggcaaaag aacttggtgg caaggctgta      300

gtaaaggctc aaattcatgc aggcgggcgc ggcaaggcgg gtggcgtcaa agtctcgaag      360

tccctggagg aggtcgaggc gaacgcccgc gagcttctcg gcaagcggct cgtcacgcac      420

caaacgggac cgcagggccg aattgtacgg cgactgctca tcgaagagct cacgaatatc      480

cagaaggagt actacatagg cctcgttctt gaccgatccc agggacgctt ggtgatgatg      540

gcctcccagg agggcggcgt cgagatcgaa gaggtagctg caaaacaccc ggaaaagatt      600

ttccgtgaga ccattgatcc actgacgggg ctcacgccgt tccaggcgaa caacctcgcg      660

tacaagcttg agctgcctca ggatgcggtg aaaaaggccg ctcaattcat gatggcgctt      720

tacaacgcgt acgtcgcgaa ggattgctcc atcgcggaga tcaatccgct ggtactgaca      780

gcggaaggcg acatcatcgc cctggatgcg aagctcaact tcgacgacaa tgctttgtac      840

cggcatcccg agatcgtcag cctgcgcgac gaggacgaag aagatccgaa ggaaatcgaa      900

gcctcgaaat acggtttgag ttacatcgcg ctggacggca acattggatg catggtgaat      960

ggtgcgggcc tggccatggc cacgatggac accatcaagt attacggcgg agagcctgcg     1020

aacttcctgg acgtcggtgg aggcgccagc gaagagaaag tgacggcggc gttcaaaatc     1080

atcctgtcgg atcctaaagt gaaaggtatc ctcgtcaaca tcttcggcgg catcatgaag     1140

tgcgacgtga tcgcaaacgg cgtggtcgca gcggccaagc aggtcggcct ggacaagccg     1200

ctcgtggtgc gcctcgaggg cacgaacgtc gaagccggaa agaaaatctt gaacgaatcg     1260

ggtctgaagt tggtggcggc tgattcgctc gctgacgctg cccaaaagat cgtggcgctg     1320

gtctga                                                                1326


<210>   1463
<211>   299
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1463
Met Ser Ile Leu Val Asn Lys Glu Thr Arg Val Ile Thr Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Ala Gly Leu Phe His Thr Gln Gln Ala Leu Ala Tyr Gly 
            20                  25                  30          

Thr Lys Val Val Gly Gly Thr Ser Pro Gly Lys Gly Gly Thr Lys Val 
        35                  40                  45              

Glu Gly Leu Pro Val Phe Asn Thr Val Glu Glu Ala Val Arg Glu Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Ala Ala Gly Ile Glu Leu Val Val Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Ile Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Asn Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Thr 
    130                 135                 140                 

Pro Gly Lys Ile Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val Tyr Gln Leu Thr Gln Leu Gly Leu Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Val Asp Val Leu 
            180                 185                 190         

Lys Met Phe Asn Asp Asp Pro Asp Thr Glu Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Ser Ala Glu Glu Glu Ala Ala Glu Trp Ile Lys Ala 
    210                 215                 220                 

Asn Met Lys Lys Pro Val Val Gly Phe Ile Ala Gly Ala Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Arg Arg Met Gly His Ala Gly Ala Ile Val Ser Gly Gly Ser 
                245                 250                 255     

Gly Thr Ala Gln Ser Lys Ile Glu Lys Met Lys Ala Cys Gly Ile Arg 
            260                 265                 270         

Val Ala Pro Thr Pro Ser Glu Met Gly Ser Thr Leu Tyr Gln Val Leu 
        275                 280                 285             

Glu Glu Arg Gly Leu Leu Glu Arg Cys Lys Ser 
    290                 295                 

<210>   1464
<211>   900
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1464
atgagcattc tggtgaacaa ggaaacgcgc gtcattaccc agggcatcac gggatctgcc       60

ggtctgtttc acacgcagca ggcgcttgcc tacggcacga aggtcgtggg tggcacctcc      120

ccagggaagg gcggcacaaa ggtcgaggga ttgccggtct tcaacacggt tgaggaggcc      180

gtgcgcgaga cgggcgcaaa tgcgtcggtc atttacgttc cgcctgcatt cgccgcggac      240

gccatcatgg aggccgttgc ggccggaatc gaacttgtcg tgtgcatcac ggaaggtatt      300

ccgattcttg atatggtgaa ggtcaagcgg tacatggagg gcaagaagac gcggctcatt      360

ggcccgaact gtcctggcgt gatcacgccg aacgagtgca agatcggcat catgcctgga      420

tacattcaca cgcctggaaa aatcggcgtc gtgtctcgct cgggaacgct gacctacgaa      480

gccgtgtacc agttgacgca gctcgggctc ggccagtcga cggccgtcgg gatcggcggc      540

gatccggtca acgggacaaa ctttgtcgac gtgctgaaga tgttcaacga cgacccggat      600

accgaagccg tgatcatgat cggcgagatc ggtggatcgg cggaagaaga agcggcagag      660

tggattaagg ccaacatgaa aaagcccgtc gttggcttta tcgcgggtgc cacagcccct      720

ccgggaaggc ggatgggtca tgcgggggcg attgtgtccg gtggttccgg cacggcgcag      780

tccaagatcg agaagatgaa ggcgtgcggc atccgagtgg ctcccacccc gtctgagatg      840

ggctcgacgt tgtatcaggt gctggaagag cgcggcttgc tcgagcgctg caagtcgtga      900


<210>   1465
<211>   299
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1465
Met Ser Val Phe Val Asn Lys Asp Thr Lys Val Ile Val Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Gln Gly Leu Phe His Thr Lys Gln Met Ile Glu Tyr Gly 
            20                  25                  30          

Thr Asn Ile Val Gly Gly Val Thr Pro Gly Lys Gly Gly Thr Glu Val 
        35                  40                  45              

Glu Gly Val Pro Val Phe Asp Thr Val Ser Glu Ala Val Glu Arg Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Asp Ala Gly Leu Asp Leu Val Val Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Val Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Glu Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Lys 
    130                 135                 140                 

Lys Gly His Val Gly Ile Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val His Gln Leu Thr Gln Ala Gly Ile Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Ile Asp Val Leu 
            180                 185                 190         

Lys Ala Phe Asn Glu Asp Glu Glu Thr Tyr Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Thr Ala Glu Glu Glu Ala Ala Glu Trp Val Lys Ala 
    210                 215                 220                 

Asn Met Thr Lys Pro Val Val Gly Phe Ile Gly Gly Gln Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Lys Arg Met Gly His Ala Gly Ala Ile Ile Ser Gly Gly Lys 
                245                 250                 255     

Gly Thr Ala Ala Glu Lys Ile Lys Lys Met Thr Glu Cys Gly Ile Lys 
            260                 265                 270         

Val Ala Glu Thr Pro Ala Val Ile Gly Glu Thr Leu Ile Ser Val Leu 
        275                 280                 285             

Lys Glu Arg Gly Leu Tyr Glu Lys Cys Lys Thr 
    290                 295                 

<210>   1466
<211>   299
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1466
Met Ser Val Phe Val Asn Lys Asp Thr Lys Val Ile Val Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Gln Gly Leu Phe His Thr Lys Gln Met Ile Glu Tyr Gly 
            20                  25                  30          

Thr Asn Ile Val Gly Gly Val Thr Pro Gly Lys Gly Gly Thr Glu Val 
        35                  40                  45              

Glu Gly Val Pro Val Phe Asp Thr Val Ser Glu Ala Val Glu Lys Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Asp Ala Glu Leu Asp Leu Val Val Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Val Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Glu Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Lys 
    130                 135                 140                 

Lys Gly His Val Gly Ile Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val His Gln Leu Thr Gln Ala Gly Ile Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Ile Asp Val Leu 
            180                 185                 190         

Lys Ala Phe Asn Glu Asp Asp Glu Thr Tyr Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Thr Ala Glu Glu Glu Ala Ala Glu Trp Val Lys Ala 
    210                 215                 220                 

Asn Met Thr Lys Pro Val Val Gly Phe Ile Gly Gly Gln Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Lys Arg Met Gly His Ala Gly Ala Ile Ile Ser Gly Gly Lys 
                245                 250                 255     

Gly Thr Ala Ala Glu Lys Ile Lys Lys Met Asn Glu Cys Gly Ile Lys 
            260                 265                 270         

Val Ala Glu Thr Pro Ala Val Ile Gly Glu Thr Leu Ile Ser Val Leu 
        275                 280                 285             

Lys Glu Arg Gly Leu Tyr Glu Lys Cys Lys Thr 
    290                 295                 

<210>   1467
<211>   299
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1467
Met Ser Val Phe Ile Asn Lys Asp Thr Lys Val Ile Val Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Thr Ala Leu Phe His Thr Lys Gln Met Leu Glu Tyr Gly 
            20                  25                  30          

Thr Lys Ile Val Gly Gly Val Thr Pro Gly Lys Gly Gly Thr Glu Val 
        35                  40                  45              

Glu Gly Val Pro Val Phe Asn Thr Val Glu Glu Ala Val Lys Gln Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Ala Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Thr Asp Ala Glu Leu Asp Leu Val Ile Cys Ile 
                85                  90                  95      

Thr Glu His Ile Pro Val Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Glu Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Lys 
    130                 135                 140                 

Lys Gly His Val Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val His Gln Leu Ser Glu Ala Gly Val Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Ile Asp Val Leu 
            180                 185                 190         

Lys Ala Phe Asn Glu Asp Pro Asp Thr His Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Thr Ala Glu Glu Glu Ala Ala Glu Trp Val Lys Ala 
    210                 215                 220                 

Asn Met Thr Lys Pro Val Val Gly Phe Ile Gly Gly Lys Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Lys Arg Met Gly His Ala Gly Ala Ile Ile Ser Gly Gly Lys 
                245                 250                 255     

Gly Thr Ala Asp Glu Lys Ile Lys Thr Met Asn Ala Cys Gly Ile Glu 
            260                 265                 270         

Val Ala Glu Thr Pro Ser Val Met Gly Glu Thr Leu Ile Lys Val Leu 
        275                 280                 285             

Lys Glu Lys Gly Leu Tyr Glu Thr Cys Lys Thr 
    290                 295                 

<210>   1468
<211>   297
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   1468
Met Ser Ile Leu Ile Asn Lys Asp Thr Lys Val Ile Val Gln Gly Ile 
                5                   10                  15      

Thr Gly Ala Thr Gly Leu Phe His Thr Lys Gln Ala Val Glu Tyr Gly 
            20                  25                  30          

Thr Asn Ile Val Gly Gly Val Thr Pro Gly Lys Gly Gly Thr Glu Val 
        35                  40                  45              

Glu Gly Ile Pro Val Phe Asp Thr Val Ser Gln Ala Val Glu Ala Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Asp Ala Glu Leu Asp Leu Ala Ile Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Val Met Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Val Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Glu Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Lys 
    130                 135                 140                 

Lys Gly His Val Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val His Gln Leu Ser Thr Ala Gly Ile Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Ile Asp Val Leu 
            180                 185                 190         

Lys Leu Phe Asn Glu Asp Pro Asp Thr Tyr Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Thr Ala Glu Glu Glu Ala Ala Glu Trp Ile Lys Ala 
    210                 215                 220                 

Asn Met Thr Lys Pro Val Val Gly Phe Ile Gly Gly Gln Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Lys Arg Met Gly His Ala Gly Ala Ile Ile Ser Gly Gly Lys 
                245                 250                 255     

Gly Thr Ala Ala Glu Lys Ile Lys Thr Leu Glu Ser Cys Gly Val Lys 
            260                 265                 270         

Val Ala Glu Thr Pro Ser Val Met Gly Glu Thr Leu Ile Ser Val Leu 
        275                 280                 285             

Lys Glu Gln Gly Leu Leu Glu Lys Cys 
    290                 295         

<210>   1469
<211>   299
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   1469
Met Ser Val Phe Ile Asn Lys Asp Thr Lys Val Ile Val Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Thr Ala Leu Phe His Thr Lys Gln Met Leu Glu Tyr Gly 
            20                  25                  30          

Thr Gln Ile Val Gly Gly Thr Thr Pro Gly Lys Gly Gly Met Glu Val 
        35                  40                  45              

Glu Gly Val Pro Val Phe Asn Thr Val Gln Glu Ala Val Lys Glu Thr 
    50                  55                  60                  

Gly Ala Thr Ala Ser Val Ile Tyr Val Pro Ala Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Leu Glu Ala Val Asp Ala Glu Leu Asp Leu Ala Ile Cys Ile 
                85                  90                  95      

Thr Glu His Ile Pro Val Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Val Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Asp Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Thr 
    130                 135                 140                 

Lys Gly His Val Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val His Gln Leu Thr Gln Ala Gly Ile Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Ile Asp Val Leu 
            180                 185                 190         

Lys Ala Phe Asn Glu Asp Pro Glu Thr Lys Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Thr Ala Glu Glu Glu Ala Ala Glu Trp Val Lys Ala 
    210                 215                 220                 

Asn Met Thr Lys Pro Val Val Gly Phe Ile Gly Gly Arg Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Lys Arg Met Gly His Ala Gly Ala Ile Ile Ser Gly Gly Lys 
                245                 250                 255     

Gly Thr Ala Asp Glu Lys Ile Arg Val Met Asn Glu Cys Gly Ile Gln 
            260                 265                 270         

Val Ala Asp Thr Pro Ser Val Met Gly Glu Thr Leu Ile Lys Val Leu 
        275                 280                 285             

Lys Glu Lys Gly Leu Phe Asp Glu Cys Lys Thr 
    290                 295                 

<210>   1470
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1463

<400>   1470
Met Ser Ile Leu Val Asn Lys Glu Thr Arg Val Ile Thr Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Ala Gly Leu Phe His Thr Gln Gln Ala Leu Ala Tyr Gly 
            20                  25                  30          

Thr Lys Val Val Gly Gly Thr Ser Pro Gly Lys Gly Gly Thr Lys Val 
        35                  40                  45              

Glu Gly Leu Pro Val Phe Asn Thr Val Glu Glu Ala Val Arg Glu Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Ala Ala Gly Ile Glu Leu Val Val Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Ile Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Asn Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Thr 
    130                 135                 140                 

Pro Gly Lys Ile Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val Tyr Gln Leu Thr Gln Leu Gly Leu Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Val Asp Val Leu 
            180                 185                 190         

Lys Met Phe Asn Asp Asp Pro Asp Thr Asp Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Ser Ala Glu Glu Glu Ala Ala Glu Trp Ile Lys Ala 
    210                 215                 220                 

Asn Met Lys Lys Pro Val Val Gly Phe Ile Ala Gly Ala Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Arg Arg Met Gly His Ala Gly Ala Ile Val Ser Gly Gly Ser 
                245                 250                 255     

Gly Thr Ala Gln Ser Lys Ile Glu Lys Met Lys Ala Cys Gly Ile Arg 
            260                 265                 270         

Val Ala Pro Thr Pro Ser Glu Met Gly Ser Thr Leu Tyr Gln Val Leu 
        275                 280                 285             

Glu Glu Arg Gly Leu Leu Glu Arg Cys Lys Ser 
    290                 295                 

<210>   1471
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1463

<400>   1471
Met Ser Ile Leu Val Asn Lys Glu Thr Arg Val Ile Thr Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Ala Gly Leu Phe His Thr Gln Gln Ala Leu Ala Tyr Gly 
            20                  25                  30          

Thr Lys Val Val Gly Gly Thr Ser Pro Gly Lys Gly Gly Thr Lys Val 
        35                  40                  45              

Glu Gly Leu Pro Val Phe Asn Thr Val Glu Glu Ala Val Arg Glu Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Ala Ala Gly Ile Glu Leu Val Val Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Ile Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Asn Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Thr 
    130                 135                 140                 

Pro Gly Lys Ile Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val Tyr Gln Leu Thr Gln Leu Gly Leu Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Val Asp Val Leu 
            180                 185                 190         

Lys Met Phe Asn Asp Asp Pro Asp Thr Glu Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Ser Ala Glu Glu Glu Ala Ala Glu Trp Ile Lys Ala 
    210                 215                 220                 

Asn Met Lys Lys Pro Val Val Gly Phe Ile Ala Gly Ala Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Arg Arg Met Gly His Ala Gly Ala Ile Val Ser Gly Gly Ser 
                245                 250                 255     

Gly Thr Ala Gln Ser Lys Ile Glu Lys Met Arg Ala Cys Gly Ile Arg 
            260                 265                 270         

Val Ala Pro Thr Pro Ser Glu Met Gly Ser Thr Leu Tyr Gln Val Leu 
        275                 280                 285             

Glu Glu Arg Gly Leu Leu Glu Arg Cys Lys Ser 
    290                 295                 

<210>   1472
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1463

<400>   1472
Met Ser Ile Leu Val Asn Lys Glu Thr Arg Val Ile Thr Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Ala Gly Leu Phe His Thr Gln Gln Ala Leu Ala Tyr Gly 
            20                  25                  30          

Thr Lys Val Val Gly Gly Thr Ser Pro Gly Lys Gly Gly Thr Lys Val 
        35                  40                  45              

Glu Gly Leu Pro Val Phe Asn Thr Val Glu Glu Ala Val Arg Glu Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Ala Ala Gly Ile Glu Leu Val Val Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Ile Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Asn Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Thr 
    130                 135                 140                 

Pro Gly Lys Ile Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val Tyr Gln Leu Thr Gln Leu Gly Leu Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Val Asp Val Leu 
            180                 185                 190         

Lys Met Phe Asn Asp Asp Pro Asp Thr Glu Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Ser Ala Glu Glu Glu Ala Ala Glu Trp Ile Lys Ala 
    210                 215                 220                 

Asn Met Lys Lys Pro Val Val Gly Phe Ile Ala Gly Ala Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Arg Arg Met Gly His Ala Gly Ala Ile Val Ser Gly Gly Ser 
                245                 250                 255     

Gly Thr Ala Gln Ser Lys Ile Glu Arg Met Lys Ala Cys Gly Ile Arg 
            260                 265                 270         

Val Ala Pro Thr Pro Ser Glu Met Gly Ser Thr Leu Tyr Gln Val Leu 
        275                 280                 285             

Glu Glu Arg Gly Leu Leu Glu Arg Cys Lys Ser 
    290                 295                 

<210>   1473
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1463

<400>   1473
Met Ser Ile Leu Val Asn Lys Glu Thr Arg Val Ile Thr Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Ala Gly Leu Phe His Thr Gln Gln Ala Leu Ala Tyr Gly 
            20                  25                  30          

Thr Lys Val Val Gly Gly Thr Ser Pro Gly Lys Gly Gly Thr Lys Val 
        35                  40                  45              

Glu Gly Leu Pro Val Phe Asn Thr Val Glu Glu Ala Val Arg Asp Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Ala Ala Gly Ile Glu Leu Val Val Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Ile Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Asn Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Thr 
    130                 135                 140                 

Pro Gly Lys Ile Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val Tyr Gln Leu Thr Gln Leu Gly Leu Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Val Asp Val Leu 
            180                 185                 190         

Lys Met Phe Asn Asp Asp Pro Asp Thr Glu Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Ser Ala Glu Glu Glu Ala Ala Glu Trp Ile Lys Ala 
    210                 215                 220                 

Asn Met Lys Lys Pro Val Val Gly Phe Ile Ala Gly Ala Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Arg Arg Met Gly His Ala Gly Ala Ile Val Ser Gly Gly Ser 
                245                 250                 255     

Gly Thr Ala Gln Ser Lys Ile Glu Lys Met Lys Ala Cys Gly Ile Arg 
            260                 265                 270         

Val Ala Pro Thr Pro Ser Glu Met Gly Ser Thr Leu Tyr Gln Val Leu 
        275                 280                 285             

Glu Glu Arg Gly Leu Leu Glu Arg Cys Lys Ser 
    290                 295                 

<210>   1474
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1463

<400>   1474
Met Ser Ile Leu Val Asn Lys Glu Thr Arg Val Ile Thr Gln Gly Ile 
                5                   10                  15      

Thr Gly Ser Ala Gly Leu Phe His Thr Gln Gln Ala Leu Ala Tyr Gly 
            20                  25                  30          

Thr Lys Val Val Gly Gly Thr Ser Pro Gly Lys Gly Gly Thr Lys Val 
        35                  40                  45              

Glu Gly Leu Pro Val Phe Asn Thr Val Glu Glu Ala Val Arg Glu Thr 
    50                  55                  60                  

Gly Ala Asn Ala Ser Val Ile Tyr Val Pro Pro Ala Phe Ala Ala Asp 
65                  70                  75                  80  

Ala Ile Met Glu Ala Val Ala Ala Gly Ile Glu Leu Val Val Cys Ile 
                85                  90                  95      

Thr Glu Gly Ile Pro Ile Leu Asp Met Val Lys Val Lys Arg Tyr Met 
            100                 105                 110         

Glu Gly Lys Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
        115                 120                 125             

Thr Pro Asn Glu Cys Lys Ile Gly Ile Met Pro Gly Tyr Ile His Thr 
    130                 135                 140                 

Pro Gly Lys Ile Gly Val Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
145                 150                 155                 160 

Ala Val Tyr Gln Leu Thr Gln Ile Gly Leu Gly Gln Ser Thr Ala Val 
                165                 170                 175     

Gly Ile Gly Gly Asp Pro Val Asn Gly Thr Asn Phe Val Asp Val Leu 
            180                 185                 190         

Lys Met Phe Asn Asp Asp Pro Asp Thr Glu Ala Val Ile Met Ile Gly 
        195                 200                 205             

Glu Ile Gly Gly Ser Ala Glu Glu Glu Ala Ala Glu Trp Ile Lys Ala 
    210                 215                 220                 

Asn Met Lys Lys Pro Val Val Gly Phe Ile Ala Gly Ala Thr Ala Pro 
225                 230                 235                 240 

Pro Gly Arg Arg Met Gly His Ala Gly Ala Ile Val Ser Gly Gly Ser 
                245                 250                 255     

Gly Thr Ala Gln Ser Lys Ile Glu Lys Met Lys Ala Cys Gly Ile Arg 
            260                 265                 270         

Val Ala Pro Thr Pro Ser Glu Met Gly Ser Thr Leu Tyr Gln Val Leu 
        275                 280                 285             

Glu Glu Arg Gly Leu Leu Glu Arg Cys Lys Ser 
    290                 295                 

<210>   1475
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1464

<400>   1475
atgagcattc tggtgaacaa ggaaacgcgc gtcattaccc agggcatcac gggatctgcc       60

ggtctgtttc acacgcagca ggcgcttgcc tacggcacga aggtcgtggg tggcacctcc      120

ccagggaagg gcggcacaaa ggtcgaggga ttgccggtct tcaacacggt tgaggaggcc      180

gtgcgcgaga cgggcgcaaa tgcgtcggtc atttacgttc cgcctgcatt cgccgcggac      240

gccatcatgg aggccgttgc ggccggaatc gaacttgtcg tgtgcatcac ggaaggtatt      300

ccgattcttg atatggtgaa ggtcaagcgg tacatggagg gcaagaagac gcggctcatt      360

ggcccgaact gtcctggcgt gatcacgccg aacgagtgca agatcggcat catgcctgga      420

tacattcaca cgcctggaaa aatcggcgtc gtgtctcgct cgggaacgct gacctacgaa      480

gccgtgtacc agttgacgca gctcgggctc ggccagtcga cggccgtcgg gatcggcggc      540

gatccggtca acgggacaaa ctttgtcgac gtgctgaaga tgttcaacga cgacccggat      600

accgatgccg tgatcatgat cggcgagatc ggtggatcgg cggaagaaga agcggcagag      660

tggattaagg ccaacatgaa aaagcccgtc gttggcttta tcgcgggtgc cacagcccct      720

ccgggaaggc ggatgggtca tgcgggggcg attgtgtccg gtggttccgg cacggcgcag      780

tccaagatcg agaagatgaa ggcgtgcggc atccgagtgg ctcccacccc gtctgagatg      840

ggctcgacgt tgtatcaggt gctggaagag cgcggcttgc tcgagcgctg caagtcgtga      900


<210>   1476
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1464

<400>   1476
atgagcattc tggtgaacaa ggaaacgcgc gtcattaccc agggcatcac gggatctgcc       60

ggtctgtttc acacgcagca ggcgcttgcc tacggcacga aggtcgtggg tggcacctcc      120

ccagggaagg gcggcacaaa ggtcgaggga ttgccggtct tcaacacggt tgaggaggcc      180

gtgcgcgaga cgggcgcaaa tgcgtcggtc atttacgttc cgcctgcatt cgccgcggac      240

gccatcatgg aggccgttgc ggccggaatc gaacttgtcg tgtgcatcac ggaaggtatt      300

ccgattcttg atatggtgaa ggtcaagcgg tacatggagg gcaagaagac gcggctcatt      360

ggcccgaact gtcctggcgt gatcacgccg aacgagtgca agatcggcat catgcctgga      420

tacattcaca cgcctggaaa aatcggcgtc gtgtctcgct cgggaacgct gacctacgaa      480

gccgtgtacc agttgacgca gctcgggctc ggccagtcga cggccgtcgg gatcggcggc      540

gatccggtca acgggacaaa ctttgtcgac gtgctgaaga tgttcaacga cgacccggat      600

accgaagccg tgatcatgat cggcgagatc ggtggatcgg cggaagaaga agcggcagag      660

tggattaagg ccaacatgaa aaagcccgtc gttggcttta tcgcgggtgc cacagcccct      720

ccgggaaggc ggatgggtca tgcgggggcg attgtgtccg gtggttccgg cacggcgcag      780

tccaagatcg agaagatgcg tgcgtgcggc atccgagtgg ctcccacccc gtctgagatg      840

ggctcgacgt tgtatcaggt gctggaagag cgcggcttgc tcgagcgctg caagtcgtga      900


<210>   1477
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1464

<400>   1477
atgagcattc tggtgaacaa ggaaacgcgc gtcattaccc agggcatcac gggatctgcc       60

ggtctgtttc acacgcagca ggcgcttgcc tacggcacga aggtcgtggg tggcacctcc      120

ccagggaagg gcggcacaaa ggtcgaggga ttgccggtct tcaacacggt tgaggaggcc      180

gtgcgcgaga cgggcgcaaa tgcgtcggtc atttacgttc cgcctgcatt cgccgcggac      240

gccatcatgg aggccgttgc ggccggaatc gaacttgtcg tgtgcatcac ggaaggtatt      300

ccgattcttg atatggtgaa ggtcaagcgg tacatggagg gcaagaagac gcggctcatt      360

ggcccgaact gtcctggcgt gatcacgccg aacgagtgca agatcggcat catgcctgga      420

tacattcaca cgcctggaaa aatcggcgtc gtgtctcgct cgggaacgct gacctacgaa      480

gccgtgtacc agttgacgca gctcgggctc ggccagtcga cggccgtcgg gatcggcggc      540

gatccggtca acgggacaaa ctttgtcgac gtgctgaaga tgttcaacga cgacccggat      600

accgaagccg tgatcatgat cggcgagatc ggtggatcgg cggaagaaga agcggcagag      660

tggattaagg ccaacatgaa aaagcccgtc gttggcttta tcgcgggtgc cacagcccct      720

ccgggaaggc ggatgggtca tgcgggggcg attgtgtccg gtggttccgg cacggcgcag      780

tccaagatcg agcgtatgaa ggcgtgcggc atccgagtgg ctcccacccc gtctgagatg      840

ggctcgacgt tgtatcaggt gctggaagag cgcggcttgc tcgagcgctg caagtcgtga      900


<210>   1478
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1464

<400>   1478
atgagcattc tggtgaacaa ggaaacgcgc gtcattaccc agggcatcac gggatctgcc       60

ggtctgtttc acacgcagca ggcgcttgcc tacggcacga aggtcgtggg tggcacctcc      120

ccagggaagg gcggcacaaa ggtcgaggga ttgccggtct tcaacacggt tgaggaggcc      180

gtgcgcgata cgggcgcaaa tgcgtcggtc atttacgttc cgcctgcatt cgccgcggac      240

gccatcatgg aggccgttgc ggccggaatc gaacttgtcg tgtgcatcac ggaaggtatt      300

ccgattcttg atatggtgaa ggtcaagcgg tacatggagg gcaagaagac gcggctcatt      360

ggcccgaact gtcctggcgt gatcacgccg aacgagtgca agatcggcat catgcctgga      420

tacattcaca cgcctggaaa aatcggcgtc gtgtctcgct cgggaacgct gacctacgaa      480

gccgtgtacc agttgacgca gctcgggctc ggccagtcga cggccgtcgg gatcggcggc      540

gatccggtca acgggacaaa ctttgtcgac gtgctgaaga tgttcaacga cgacccggat      600

accgaagccg tgatcatgat cggcgagatc ggtggatcgg cggaagaaga agcggcagag      660

tggattaagg ccaacatgaa aaagcccgtc gttggcttta tcgcgggtgc cacagcccct      720

ccgggaaggc ggatgggtca tgcgggggcg attgtgtccg gtggttccgg cacggcgcag      780

tccaagatcg agaagatgaa ggcgtgcggc atccgagtgg ctcccacccc gtctgagatg      840

ggctcgacgt tgtatcaggt gctggaagag cgcggcttgc tcgagcgctg caagtcgtga      900


<210>   1479
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1464

<400>   1479
atgagcattc tggtgaacaa ggaaacgcgc gtcattaccc agggcatcac gggatctgcc       60

ggtctgtttc acacgcagca ggcgcttgcc tacggcacga aggtcgtggg tggcacctcc      120

ccagggaagg gcggcacaaa ggtcgaggga ttgccggtct tcaacacggt tgaggaggcc      180

gtgcgcgaga cgggcgcaaa tgcgtcggtc atttacgttc cgcctgcatt cgccgcggac      240

gccatcatgg aggccgttgc ggccggaatc gaacttgtcg tgtgcatcac ggaaggtatt      300

ccgattcttg atatggtgaa ggtcaagcgg tacatggagg gcaagaagac gcggctcatt      360

ggcccgaact gtcctggcgt gatcacgccg aacgagtgca agatcggcat catgcctgga      420

tacattcaca cgcctggaaa aatcggcgtc gtgtctcgct cgggaacgct gacctacgaa      480

gccgtgtacc agttgacgca gattgggctc ggccagtcga cggccgtcgg gatcggcggc      540

gatccggtca acgggacaaa ctttgtcgac gtgctgaaga tgttcaacga cgacccggat      600

accgaagccg tgatcatgat cggcgagatc ggtggatcgg cggaagaaga agcggcagag      660

tggattaagg ccaacatgaa aaagcccgtc gttggcttta tcgcgggtgc cacagcccct      720

ccgggaaggc ggatgggtca tgcgggggcg attgtgtccg gtggttccgg cacggcgcag      780

tccaagatcg agaagatgaa ggcgtgcggc atccgagtgg ctcccacccc gtctgagatg      840

ggctcgacgt tgtatcaggt gctggaagag cgcggcttgc tcgagcgctg caagtcgtga      900


<210>   1480
<211>   167
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1480
Met Phe Gln Val Gly Gly Ile Phe Gln Val Gly Thr Phe Ile Phe Ser 
                5                   10                  15      

Val Ile Ser Phe Leu Ile Val Phe Phe Ile Ile Gln Arg Phe Ala Phe 
            20                  25                  30          

Lys Pro Leu Ala Arg Met Leu Glu Gln Arg Arg Ile His Ile Glu Thr 
        35                  40                  45              

Gln Ile Ser Glu Ala Glu Lys Ser Arg Glu Glu Ala Glu Arg Leu Leu 
    50                  55                  60                  

Ala Glu Gln Gln Arg Leu Leu Glu Glu Ala Arg Lys Glu Ala Arg Asn 
65                  70                  75                  80  

Leu Leu Asp Gln Ala Arg Ile Arg Ala Asp Glu Gln Ala Arg Glu Ile 
                85                  90                  95      

Val Gln Lys Ala Glu Glu Glu Ala Ala Arg Ile Leu Glu Glu Ser Arg 
            100                 105                 110         

Gln Ala Ile Val Arg Glu Arg Asp Glu Ala Leu Ala Ala Val Thr Lys 
        115                 120                 125             

Arg Val Ala Glu Leu Ser Val Glu Leu Thr Thr Lys Leu Leu Arg Asp 
    130                 135                 140                 

His Val Thr Ala Glu Leu His Lys Glu Leu Val Ala Glu Ala Glu Ser 
145                 150                 155                 160 

Lys Leu Gly Glu Leu Val Cys 
                165         

<210>   1481
<211>   504
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1481
gtgttccagg tgggcggcat ctttcaagtt ggaacgttca tcttctccgt gatctcgttc       60

ctcatcgtgt tcttcatcat tcagcggttt gcgttcaagc cgctggcgcg aatgctggaa      120

cagcggagaa ttcatatcga gacccagatc agcgaggccg aaaagagccg cgaagaagca      180

gagcggctgc tggccgaaca acagcgcttg ttggaagagg cgcgcaaaga agcgcggaac      240

ctgctggatc aagcccgcat tcgcgccgat gagcaggcgc gcgagatcgt gcagaaggcc      300

gaagaggagg ctgcccggat tctcgaggag agccgccaag ccattgtccg cgagcgggac      360

gaggcgctgg ccgccgtcac gaagcgcgtg gcggagttgt ctgtcgaatt gaccaccaag      420

ttgctgcgcg atcacgtcac ggccgaattg cacaaggaac tcgtggcaga ggccgagagc      480

aagctgggtg agctcgtatg ctga                                             504


<210>   1482
<211>   128
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1482
Arg Lys Phe Ala Trp Gly Pro Leu Met Gly Val Met Lys Gln Arg Glu 
                5                   10                  15      

Glu His Ile Ala Asn Glu Ile Asp Gln Ala Glu Lys Arg Arg Gln Glu 
            20                  25                  30          

Ala Glu Lys Leu Leu Glu Glu Gln Arg Glu Leu Leu Lys Gln Ser Arg 
        35                  40                  45              

Gln Glu Ala Gln Thr Ile Leu Glu Asn Ala Arg Lys Leu Ala Glu Glu 
    50                  55                  60                  

Gln Lys Glu Gln Ile Val Ala Ser Ala Arg Ala Glu Ala Glu Arg Val 
65                  70                  75                  80  

Lys Glu Ala Ala Lys Gln Glu Ile Glu Arg Glu Lys Glu Gln Ala Met 
                85                  90                  95      

Ala Ala Leu Arg Glu Gln Val Ala Ser Leu Ser Val Leu Ile Ala Ser 
            100                 105                 110         

Lys Val Ile Glu Arg Glu Leu Thr Glu Gln Asp Gln Arg Lys Leu Ile 
        115                 120                 125             

<210>   1483
<211>   140
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   1483
Arg Arg Phe Ala Trp Asn Pro Leu Ile Asn Met Met Glu Glu Arg Arg 
                5                   10                  15      

Ser Gln Ile Glu Ala Asn Ile Ala Asn Ala Glu Lys Glu Arg Leu Gln 
            20                  25                  30          

Ala Glu Gln Ile Lys Arg Glu Tyr Gln Glu Glu Met Arg Lys Ala Arg 
        35                  40                  45              

Gln Glu Ala Gln Glu Val Ile Ala Lys Ala Thr Lys Leu Ser Glu Gln 
    50                  55                  60                  

Arg Ala Ala Glu Ile Leu Ala Ala Ala His Gly Glu Ala Glu Lys Ile 
65                  70                  75                  80  

Lys Gln Ser Ala Leu Ala Asp Ile Glu Arg Glu Arg Asp Arg Ala Ile 
                85                  90                  95      

Ala Gln Val Gln Ala Gln Val Ala Asp Leu Ser Val Ala Val Ala Glu 
            100                 105                 110         

Lys Ile Ile Arg Lys Asn Leu Asp Val Arg Gly Gln Glu Asp Met Ile 
        115                 120                 125             

Glu Gln Phe Ile Gln Glu Val Gly Glu Leu Pro Cys 
    130                 135                 140 

<210>   1484
<211>   128
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1484
Arg Lys Phe Ala Trp Gln Pro Leu Met Asn Ile Met Lys Gln Arg Glu 
                5                   10                  15      

Glu His Ile Ala Asn Glu Ile Asp Gln Ala Glu Lys Arg Arg Gln Glu 
            20                  25                  30          

Ala Glu Lys Leu Leu Glu Glu Gln Arg Glu Leu Met Lys Gln Ser Arg 
        35                  40                  45              

Gln Glu Ala Gln Ala Leu Ile Glu Asn Ala Arg Lys Leu Ala Glu Glu 
    50                  55                  60                  

Gln Lys Glu Gln Ile Val Ala Ser Ala Arg Ala Glu Ala Glu Arg Val 
65                  70                  75                  80  

Lys Glu Val Ala Lys Lys Glu Ile Glu Arg Glu Lys Glu Gln Ala Met 
                85                  90                  95      

Ala Ala Leu Arg Glu Gln Val Ala Ser Leu Ser Val Leu Ile Ala Ser 
            100                 105                 110         

Lys Val Ile Glu Lys Glu Leu Thr Glu Gln Asp Gln Arg Lys Leu Ile 
        115                 120                 125             

<210>   1485
<211>   137
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   1485
Lys Lys Phe Ala Leu Lys Pro Leu Leu Gly Ile Met Lys Gln Arg Glu 
                5                   10                  15      

Asp Tyr Ile Gly Asn Glu Ile Ser Ser Ala Glu Gln Lys His Val Gln 
            20                  25                  30          

Ala Glu Lys Leu Leu Glu Glu Gln Arg Val Leu Leu Lys Glu Ala Arg 
        35                  40                  45              

Glu Glu Ser His Thr Leu Ile Glu Asn Ala Lys Lys Ile Gly Glu Lys 
    50                  55                  60                  

Gln Lys Glu Glu Ile Ile Gln Ala Ala Arg Gln Glu Ser Glu Arg Leu 
65                  70                  75                  80  

Lys Asp Ser Ala Arg Thr Glu Ile Val Lys Glu Lys Glu Gln Ala Val 
                85                  90                  95      

Ala Ala Leu Arg Glu Gln Val Ala Ser Leu Ser Val Leu Ile Ala Ser 
            100                 105                 110         

Lys Val Ile Glu Arg Glu Leu Asp Glu Gln Ala Gln Glu Lys Leu Ile 
        115                 120                 125             

Gln Glu Tyr Leu Lys Glu Ala Gly Glu 
    130                 135         

<210>   1486
<211>   157
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1486
Phe Asn Ala Gly Thr Met Leu Phe Gln Leu Val Ala Met Leu Ile Leu 
                5                   10                  15      

Leu Ala Leu Leu Lys Lys Tyr Ala Leu Gly Pro Leu Leu Asn Ile Met 
            20                  25                  30          

Lys Glu Arg Glu Asp Tyr Ile Thr Gly Glu Ile Ser Ser Ala Glu Lys 
        35                  40                  45              

Lys Asn Glu Glu Ala Lys Lys Leu Ile Glu Glu Gln Gln Ala Leu Leu 
    50                  55                  60                  

Lys Glu Ala Arg Glu Glu Ser Gln Ser Leu Ile Glu Asn Ala Lys Lys 
65                  70                  75                  80  

Leu Gly Glu Gln Gln Lys Asp Glu Ile Ile Lys Ala Ala Arg Gln Glu 
                85                  90                  95      

Ala Glu Arg Met Lys Glu Ser Ala Arg Ser Glu Ile Val Lys Glu Arg 
            100                 105                 110         

Asp Gln Ala Val Thr Ala Leu Arg Glu Gln Val Ala Ser Leu Ser Val 
        115                 120                 125             

Met Ile Ala Ser Lys Val Ile Glu Lys Glu Leu Asp Glu Gln Ala Gln 
    130                 135                 140                 

Glu Lys Leu Ile Gln Asp Tyr Leu Lys Glu Val Gly Glu 
145                 150                 155         

<210>   1487
<211>   167
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1480

<400>   1487
Met Phe Gln Val Gly Gly Ile Phe Gln Val Gly Thr Phe Ile Phe Ser 
                5                   10                  15      

Val Ile Ser Phe Leu Ile Val Phe Phe Ile Ile Gln Arg Phe Ala Phe 
            20                  25                  30          

Lys Pro Leu Ala Arg Met Leu Glu Gln Arg Arg Ile His Ile Glu Thr 
        35                  40                  45              

Gln Ile Ser Glu Ala Glu Lys Ser Arg Glu Glu Ala Glu Arg Leu Leu 
    50                  55                  60                  

Ala Glu Asn Gln Arg Leu Leu Glu Glu Ala Arg Lys Glu Ala Arg Asn 
65                  70                  75                  80  

Leu Leu Asp Gln Ala Arg Ile Arg Ala Asp Glu Gln Ala Arg Glu Ile 
                85                  90                  95      

Val Gln Lys Ala Glu Glu Glu Ala Ala Arg Ile Leu Glu Glu Ser Arg 
            100                 105                 110         

Gln Ala Ile Val Arg Glu Arg Asp Glu Ala Leu Ala Ala Val Thr Lys 
        115                 120                 125             

Arg Val Ala Glu Leu Ser Val Glu Leu Thr Thr Lys Leu Leu Arg Asp 
    130                 135                 140                 

His Val Thr Ala Glu Leu His Lys Glu Leu Val Ala Glu Ala Glu Ser 
145                 150                 155                 160 

Lys Leu Gly Glu Leu Val Cys 
                165         

<210>   1488
<211>   167
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1480

<400>   1488
Met Phe Gln Val Gly Gly Ile Phe Asn Val Gly Thr Phe Ile Phe Ser 
                5                   10                  15      

Val Ile Ser Phe Leu Ile Val Phe Phe Ile Ile Gln Arg Phe Ala Phe 
            20                  25                  30          

Lys Pro Leu Ala Arg Met Leu Glu Gln Arg Arg Ile His Ile Glu Thr 
        35                  40                  45              

Gln Ile Ser Glu Ala Glu Lys Ser Arg Glu Glu Ala Glu Arg Leu Leu 
    50                  55                  60                  

Ala Glu Gln Gln Arg Leu Leu Glu Glu Ala Arg Lys Glu Ala Arg Asn 
65                  70                  75                  80  

Leu Leu Asp Gln Ala Arg Ile Arg Ala Asp Glu Gln Ala Arg Glu Ile 
                85                  90                  95      

Val Gln Lys Ala Glu Glu Glu Ala Ala Arg Ile Leu Glu Glu Ser Arg 
            100                 105                 110         

Gln Ala Ile Val Arg Glu Arg Asp Glu Ala Leu Ala Ala Val Thr Lys 
        115                 120                 125             

Arg Val Ala Glu Leu Ser Val Glu Leu Thr Thr Lys Leu Leu Arg Asp 
    130                 135                 140                 

His Val Thr Ala Glu Leu His Lys Glu Leu Val Ala Glu Ala Glu Ser 
145                 150                 155                 160 

Lys Leu Gly Glu Leu Val Cys 
                165         

<210>   1489
<211>   167
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1480

<400>   1489
Met Phe Gln Val Gly Gly Ile Phe Gln Val Gly Thr Phe Ile Phe Ser 
                5                   10                  15      

Val Ile Ser Phe Leu Ile Val Phe Phe Ile Ile Gln Arg Phe Ala Phe 
            20                  25                  30          

Lys Pro Leu Ala Arg Met Leu Glu Gln Arg Arg Ile His Ile Glu Thr 
        35                  40                  45              

Gln Ile Ser Glu Ala Glu Lys Ser Arg Glu Glu Ala Glu Arg Leu Leu 
    50                  55                  60                  

Ala Glu Gln Gln Arg Ile Leu Glu Glu Ala Arg Lys Glu Ala Arg Asn 
65                  70                  75                  80  

Leu Leu Asp Gln Ala Arg Ile Arg Ala Asp Glu Gln Ala Arg Glu Ile 
                85                  90                  95      

Val Gln Lys Ala Glu Glu Glu Ala Ala Arg Ile Leu Glu Glu Ser Arg 
            100                 105                 110         

Gln Ala Ile Val Arg Glu Arg Asp Glu Ala Leu Ala Ala Val Thr Lys 
        115                 120                 125             

Arg Val Ala Glu Leu Ser Val Glu Leu Thr Thr Lys Leu Leu Arg Asp 
    130                 135                 140                 

His Val Thr Ala Glu Leu His Lys Glu Leu Val Ala Glu Ala Glu Ser 
145                 150                 155                 160 

Lys Leu Gly Glu Leu Val Cys 
                165         

<210>   1490
<211>   167
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1480

<400>   1490
Met Phe Gln Val Gly Gly Ile Phe Gln Val Gly Thr Phe Ile Phe Ser 
                5                   10                  15      

Val Ile Ser Phe Leu Ile Val Phe Phe Ile Leu Gln Arg Phe Ala Phe 
            20                  25                  30          

Lys Pro Leu Ala Arg Met Leu Glu Gln Arg Arg Ile His Ile Glu Thr 
        35                  40                  45              

Gln Ile Ser Glu Ala Glu Lys Ser Arg Glu Glu Ala Glu Arg Leu Leu 
    50                  55                  60                  

Ala Glu Gln Gln Arg Leu Leu Glu Glu Ala Arg Lys Glu Ala Arg Asn 
65                  70                  75                  80  

Leu Leu Asp Gln Ala Arg Ile Arg Ala Asp Glu Gln Ala Arg Glu Ile 
                85                  90                  95      

Val Gln Lys Ala Glu Glu Glu Ala Ala Arg Ile Leu Glu Glu Ser Arg 
            100                 105                 110         

Gln Ala Ile Val Arg Glu Arg Asp Glu Ala Leu Ala Ala Val Thr Lys 
        115                 120                 125             

Arg Val Ala Glu Leu Ser Val Glu Leu Thr Thr Lys Leu Leu Arg Asp 
    130                 135                 140                 

His Val Thr Ala Glu Leu His Lys Glu Leu Val Ala Glu Ala Glu Ser 
145                 150                 155                 160 

Lys Leu Gly Glu Leu Val Cys 
                165         

<210>   1491
<211>   167
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1480

<400>   1491
Met Phe Gln Val Gly Gly Ile Phe Gln Val Gly Thr Phe Ile Phe Ser 
                5                   10                  15      

Val Ile Ser Phe Leu Ile Val Phe Phe Ile Ile Gln Arg Phe Ala Phe 
            20                  25                  30          

Lys Pro Leu Ala Arg Met Leu Glu Gln Arg Arg Ile His Ile Glu Thr 
        35                  40                  45              

Gln Ile Ser Glu Ala Glu Lys Ser Arg Asp Glu Ala Glu Arg Leu Leu 
    50                  55                  60                  

Ala Glu Gln Gln Arg Leu Leu Glu Glu Ala Arg Lys Glu Ala Arg Asn 
65                  70                  75                  80  

Leu Leu Asp Gln Ala Arg Ile Arg Ala Asp Glu Gln Ala Arg Glu Ile 
                85                  90                  95      

Val Gln Lys Ala Glu Glu Glu Ala Ala Arg Ile Leu Glu Glu Ser Arg 
            100                 105                 110         

Gln Ala Ile Val Arg Glu Arg Asp Glu Ala Leu Ala Ala Val Thr Lys 
        115                 120                 125             

Arg Val Ala Glu Leu Ser Val Glu Leu Thr Thr Lys Leu Leu Arg Asp 
    130                 135                 140                 

His Val Thr Ala Glu Leu His Lys Glu Leu Val Ala Glu Ala Glu Ser 
145                 150                 155                 160 

Lys Leu Gly Glu Leu Val Cys 
                165         

<210>   1492
<211>   504
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1481

<400>   1492
gtgttccagg tgggcggcat ctttcaagtt ggaacgttca tcttctccgt gatctcgttc       60

ctcatcgtgt tcttcatcat tcagcggttt gcgttcaagc cgctggcgcg aatgctggaa      120

cagcggagaa ttcatatcga gacccagatc agcgaggccg aaaagagccg cgaagaagca      180

gagcggctgc tggccgaaaa tcagcgcttg ttggaagagg cgcgcaaaga agcgcggaac      240

ctgctggatc aagcccgcat tcgcgccgat gagcaggcgc gcgagatcgt gcagaaggcc      300

gaagaggagg ctgcccggat tctcgaggag agccgccaag ccattgtccg cgagcgggac      360

gaggcgctgg ccgccgtcac gaagcgcgtg gcggagttgt ctgtcgaatt gaccaccaag      420

ttgctgcgcg atcacgtcac ggccgaattg cacaaggaac tcgtggcaga ggccgagagc      480

aagctgggtg agctcgtatg ctga                                             504


<210>   1493
<211>   504
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1481

<400>   1493
gtgttccagg tgggcggcat ctttaatgtt ggaacgttca tcttctccgt gatctcgttc       60

ctcatcgtgt tcttcatcat tcagcggttt gcgttcaagc cgctggcgcg aatgctggaa      120

cagcggagaa ttcatatcga gacccagatc agcgaggccg aaaagagccg cgaagaagca      180

gagcggctgc tggccgaaca acagcgcttg ttggaagagg cgcgcaaaga agcgcggaac      240

ctgctggatc aagcccgcat tcgcgccgat gagcaggcgc gcgagatcgt gcagaaggcc      300

gaagaggagg ctgcccggat tctcgaggag agccgccaag ccattgtccg cgagcgggac      360

gaggcgctgg ccgccgtcac gaagcgcgtg gcggagttgt ctgtcgaatt gaccaccaag      420

ttgctgcgcg atcacgtcac ggccgaattg cacaaggaac tcgtggcaga ggccgagagc      480

aagctgggtg agctcgtatg ctga                                             504


<210>   1494
<211>   504
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1481

<400>   1494
gtgttccagg tgggcggcat ctttcaagtt ggaacgttca tcttctccgt gatctcgttc       60

ctcatcgtgt tcttcatcat tcagcggttt gcgttcaagc cgctggcgcg aatgctggaa      120

cagcggagaa ttcatatcga gacccagatc agcgaggccg aaaagagccg cgaagaagca      180

gagcggctgc tggccgaaca acagcgcatt ttggaagagg cgcgcaaaga agcgcggaac      240

ctgctggatc aagcccgcat tcgcgccgat gagcaggcgc gcgagatcgt gcagaaggcc      300

gaagaggagg ctgcccggat tctcgaggag agccgccaag ccattgtccg cgagcgggac      360

gaggcgctgg ccgccgtcac gaagcgcgtg gcggagttgt ctgtcgaatt gaccaccaag      420

ttgctgcgcg atcacgtcac ggccgaattg cacaaggaac tcgtggcaga ggccgagagc      480

aagctgggtg agctcgtatg ctga                                             504


<210>   1495
<211>   504
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1481

<400>   1495
gtgttccagg tgggcggcat ctttcaagtt ggaacgttca tcttctccgt gatctcgttc       60

ctcatcgtgt tcttcatctt acagcggttt gcgttcaagc cgctggcgcg aatgctggaa      120

cagcggagaa ttcatatcga gacccagatc agcgaggccg aaaagagccg cgaagaagca      180

gagcggctgc tggccgaaca acagcgcttg ttggaagagg cgcgcaaaga agcgcggaac      240

ctgctggatc aagcccgcat tcgcgccgat gagcaggcgc gcgagatcgt gcagaaggcc      300

gaagaggagg ctgcccggat tctcgaggag agccgccaag ccattgtccg cgagcgggac      360

gaggcgctgg ccgccgtcac gaagcgcgtg gcggagttgt ctgtcgaatt gaccaccaag      420

ttgctgcgcg atcacgtcac ggccgaattg cacaaggaac tcgtggcaga ggccgagagc      480

aagctgggtg agctcgtatg ctga                                             504


<210>   1496
<211>   504
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1481

<400>   1496
gtgttccagg tgggcggcat ctttcaagtt ggaacgttca tcttctccgt gatctcgttc       60

ctcatcgtgt tcttcatcat tcagcggttt gcgttcaagc cgctggcgcg aatgctggaa      120

cagcggagaa ttcatatcga gacccagatc agcgaggccg aaaagagccg cgatgaagca      180

gagcggctgc tggccgaaca acagcgcttg ttggaagagg cgcgcaaaga agcgcggaac      240

ctgctggatc aagcccgcat tcgcgccgat gagcaggcgc gcgagatcgt gcagaaggcc      300

gaagaggagg ctgcccggat tctcgaggag agccgccaag ccattgtccg cgagcgggac      360

gaggcgctgg ccgccgtcac gaagcgcgtg gcggagttgt ctgtcgaatt gaccaccaag      420

ttgctgcgcg atcacgtcac ggccgaattg cacaaggaac tcgtggcaga ggccgagagc      480

aagctgggtg agctcgtatg ctga                                             504


<210>   1497
<211>   298
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1497
Met Arg Met Asp Phe Gly Ser Leu Ile Thr Ala Met Val Thr Pro Phe 
                5                   10                  15      

Asp Ala Thr Gly Ala Leu Asp Glu Gly Arg Leu Arg Arg Leu Val Asp 
            20                  25                  30          

His Leu Ile Glu Thr Gly Thr Thr Ala Val Val Val Cys Gly Thr Thr 
        35                  40                  45              

Gly Glu Ser Pro Thr Leu Ser His Ala Glu Lys Leu Arg Leu Phe Asp 
    50                  55                  60                  

Ala Thr Leu Arg Ala Val Asp Gly Arg Ile Pro Val Ile Ala Gly Thr 
65                  70                  75                  80  

Gly Thr Asn Ser Thr Lys Asp Ser Ile Glu Leu Thr Leu Glu Ala Ala 
                85                  90                  95      

Arg Leu Gly Val Gln Ala Val Met Leu Val Thr Pro Tyr Tyr Asn Arg 
            100                 105                 110         

Pro Ser Gln Glu Gly Leu Tyr Met His Phe Ala Ser Ile Ala Glu Ser 
        115                 120                 125             

Thr Thr Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Gly Val 
    130                 135                 140                 

Asn Leu Gln Pro Gln Thr Ala Leu Gln Leu Ala Ala Ile Pro Asn Val 
145                 150                 155                 160 

Val Ala Leu Lys Glu Ala Ser Gly Asp Phe Ser Gln Ile Leu Arg Ile 
                165                 170                 175     

Ala Ala Glu Lys Pro Asp Asp Phe Leu Leu Tyr Ser Gly Asp Asp Lys 
            180                 185                 190         

Phe Thr Leu Pro Met Leu Ala Ile Gly Ala Ala Gly Val Val Ser Val 
        195                 200                 205             

Ala Gly His Val Val Gly Arg Gln Ile Arg Thr Met Met Asp Leu Phe 
    210                 215                 220                 

Trp Gln Gly Gln Val Asp Glu Ala Ala Tyr Trp Ser Ala Arg Leu Leu 
225                 230                 235                 240 

Pro Ile Phe Glu Ala Met Phe Met Glu Ala Ser Pro Ala Pro Val Lys 
                245                 250                 255     

Glu Ala Leu Ser Ile Leu Gly Ile Asp Val Gly Ser Val Arg Ser Pro 
            260                 265                 270         

Leu Val Pro Ala Ser Lys Ala Leu Arg Glu His Leu Tyr Thr Leu Leu 
        275                 280                 285             

Asn Ala Leu Gly Val Ile Glu Pro Ser Ala 
    290                 295             

<210>   1498
<211>   897
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1498
atgcgtatgg attttggaag cctgatcacg gcgatggtca cgccctttga tgccacgggt       60

gcgctcgacg aggggcgcct gcggcggctg gtggaccacc tgatcgaaac gggcacgacc      120

gcggtcgtgg tgtgcgggac gacgggggaa tccccaaccc tgagccacgc ggaaaagctg      180

cgcctgttcg acgccaccct ccgggcggtg gacggccgga ttccggtgat cgcgggcacg      240

ggcaccaatt cgaccaagga ttccattgag ctcacgctcg aggccgctcg tctcggcgtg      300

caggccgtca tgctcgtgac gccgtattac aaccgcccgt ctcaggaagg gctgtacatg      360

cacttcgcca gcatcgcgga gtcgaccacc ttgccggtca tgttgtacaa cgtgccgggg      420

cggacggggg tcaatctgca gccgcagacc gcgcttcagc tcgcggccat cccgaacgtc      480

gtcgcgctca aggaggcgag cggcgacttt tcgcagatcc tccgcatcgc ggccgagaag      540

ccggacgact ttcttctcta cagcggggac gacaagttca cgttgccgat gctcgccatc      600

ggagcggcgg gcgtcgtgag cgtcgcgggc cacgtcgtcg gtcggcagat ccgcacgatg      660

atggatctct tctggcaagg gcaggtggac gaggcggcgt actggagcgc gcggctgttg      720

cccatcttcg aggccatgtt tatggaggcc agcccggcgc cggtgaagga ggcgctttcc      780

atcctcggca tcgacgtggg ctccgtccgc tcgccgcttg tgccggcctc caaggcgctc      840

cgcgagcacc tgtacacgct tctgaacgcg ctcggggtca tcgagccaag cgcatga         897


<210>   1499
<211>   289
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   1499
Met Asn Val Gly Asn Ile Ser Thr Ala Met Ile Thr Pro Phe Asp Ser 
                5                   10                  15      

Lys Gly Asn Val Asp Phe Gln Lys Leu Ser Thr Leu Ile Asp Tyr Leu 
            20                  25                  30          

Leu Lys Asn Gly Thr Asp Ser Leu Val Val Ala Gly Thr Thr Gly Glu 
        35                  40                  45              

Ser Pro Thr Leu Ser Thr Glu Glu Lys Ile Ala Leu Phe Glu Phe Thr 
    50                  55                  60                  

Val Lys Glu Val Asn Gly Arg Val Pro Val Ile Ala Gly Thr Gly Ser 
65                  70                  75                  80  

Asn Asn Thr Lys Asp Ser Ile Lys Leu Thr Lys Lys Ala Glu Glu Ala 
                85                  90                  95      

Gly Val Asp Cys Val Met Leu Val Thr Pro Tyr Tyr Asn Lys Pro Ser 
            100                 105                 110         

Gln Glu Gly Met Tyr Arg His Phe Lys Ala Ile Ala Glu Glu Thr Ser 
        115                 120                 125             

Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Val Ala Ser Leu 
    130                 135                 140                 

Ala Pro Glu Thr Ala Ile Arg Leu Ala Glu Ile Pro Asn Ile Ser Ala 
145                 150                 155                 160 

Ile Lys Glu Ala Ser Gly Asp Leu Asp Ala Ile Thr Lys Ile Ile Ala 
                165                 170                 175     

Glu Thr Pro Glu Asp Phe Tyr Val Tyr Ser Gly Asp Asp Gly Leu Thr 
            180                 185                 190         

Leu Pro Ile Leu Ala Val Gly Gly Arg Gly Val Val Ser Val Ala Ser 
        195                 200                 205             

His Ile Val Gly Ser Asp Met Gln Gln Met Ile Lys Asn Tyr Thr Asn 
    210                 215                 220                 

Gly Gln Thr Ala Thr Ala Ala Leu Ile His Gln Lys Leu Leu Pro Ile 
225                 230                 235                 240 

Met Lys Glu Leu Phe Lys Ala Pro Asn Pro Ala Pro Val Lys Thr Ala 
                245                 250                 255     

Leu Gln Leu Lys Gly Leu Asp Val Gly Ser Val Arg Leu Pro Leu Ile 
            260                 265                 270         

Pro Leu Asn Glu Asp Glu Arg Leu Ser Leu Ser Ser Val Ile Ser Glu 
        275                 280                 285             

Leu 
    

<210>   1500
<211>   290
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   1500
Met Asn Phe Gly Asn Val Ser Thr Ala Met Ile Thr Pro Phe Asp Asn 
                5                   10                  15      

Lys Gly Asn Val Asp Phe Gln Lys Leu Ser Thr Leu Ile Asp Tyr Leu 
            20                  25                  30          

Leu Lys Asn Gly Thr Asp Ser Leu Val Val Ala Gly Thr Thr Gly Glu 
        35                  40                  45              

Ser Pro Thr Leu Ser Thr Glu Glu Lys Ile Ala Leu Phe Glu Tyr Thr 
    50                  55                  60                  

Val Lys Glu Val Asn Gly Arg Val Pro Val Ile Ala Gly Thr Gly Ser 
65                  70                  75                  80  

Asn Asn Thr Lys Asp Ser Ile Lys Leu Thr Lys Lys Ala Glu Glu Ala 
                85                  90                  95      

Gly Val Asp Ala Val Met Leu Val Thr Pro Tyr Tyr Asn Lys Pro Ser 
            100                 105                 110         

Gln Glu Gly Met Tyr Gln His Phe Lys Ala Ile Ala Ala Glu Thr Ser 
        115                 120                 125             

Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Val Ala Ser Leu 
    130                 135                 140                 

Ala Pro Glu Thr Thr Ile Arg Leu Ala Ala Asp Ile Pro Asn Val Val 
145                 150                 155                 160 

Ala Ile Lys Glu Ala Ser Gly Asp Leu Glu Ala Ile Thr Lys Ile Ile 
                165                 170                 175     

Ala Glu Thr Pro Glu Asp Phe Tyr Val Tyr Ser Gly Asp Asp Ala Leu 
            180                 185                 190         

Thr Leu Pro Ile Leu Ser Val Gly Gly Arg Gly Val Val Ser Val Ala 
        195                 200                 205             

Ser His Ile Ala Gly Thr Asp Met Gln Gln Met Ile Lys Asn Tyr Thr 
    210                 215                 220                 

Asn Gly Gln Thr Ala Asn Ala Ala Leu Ile His Gln Lys Leu Leu Pro 
225                 230                 235                 240 

Ile Met Lys Glu Leu Phe Lys Ala Pro Asn Pro Ala Pro Val Lys Thr 
                245                 250                 255     

Ala Leu Gln Leu Arg Gly Leu Asp Val Gly Ser Val Arg Leu Pro Leu 
            260                 265                 270         

Val Pro Leu Thr Glu Asp Glu Arg Leu Ser Leu Ser Ser Thr Ile Ser 
        275                 280                 285             

Glu Leu 
    290 

<210>   1501
<211>   287
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1501
Phe Gly Asn Ile Val Thr Ala Met Val Thr Pro Phe Asp Arg Lys Gly 
                5                   10                  15      

Asn Leu Asp Leu Ala Lys Thr Thr Glu Leu Val Asn Tyr Leu Leu Asp 
            20                  25                  30          

Asn Gly Thr Asp Ala Leu Val Val Ala Gly Thr Thr Gly Glu Ser Pro 
        35                  40                  45              

Thr Leu Thr Ala Glu Glu Lys Val Ala Leu Phe Arg His Val Val Asn 
    50                  55                  60                  

Val Val Asn Gly Arg Val Pro Val Ile Ala Gly Thr Gly Thr Asn Asp 
65                  70                  75                  80  

Thr Arg Ala Ser Ile Glu Leu Thr Lys Arg Ala Glu Glu Thr Gly Val 
                85                  90                  95      

Asp Ala Val Met Leu Val Ala Pro Tyr Tyr Asn Lys Pro Asn Gln Glu 
            100                 105                 110         

Gly Leu Tyr Gln His Phe Lys Ala Ile Ala Glu Ser Thr Ser Leu Pro 
        115                 120                 125             

Val Met Leu Tyr Asn Val Pro Gly Arg Thr Ser Val Asn Leu Ala Pro 
    130                 135                 140                 

Glu Thr Val Ile Arg Leu Ala Ala Ile Pro Asn Ile Val Ala Val Lys 
145                 150                 155                 160 

Glu Ala Gly Gly Asn Leu Asp Ala Met Ala Glu Ile Ile Glu Gln Thr 
                165                 170                 175     

Pro Asp Asp Phe Leu Leu Tyr Ser Gly Asp Asp Ser Leu Thr Leu Pro 
            180                 185                 190         

Val Leu Ala Ile Gly Gly Ala Gly Val Val Ser Val Ala Ser His Ile 
        195                 200                 205             

Ile Gly Asn Glu Met Gln Gln Met Ile Arg Ala Phe Gln Ala Gly Asp 
    210                 215                 220                 

His Gln Lys Ala Ala Ala Leu His Arg Lys Trp Val Pro Leu Met Lys 
225                 230                 235                 240 

Gly Leu Phe Ala Ala Pro Ser Pro Val Pro Val Lys Thr Ala Leu Gln 
                245                 250                 255     

Leu Arg Gly Leu Asp Val Gly Pro Val Arg Leu Pro Leu Val Pro Leu 
            260                 265                 270         

Thr Glu Gln Glu Arg Ser Glu Leu Ser Arg Leu Leu Ser Ala Leu 
        275                 280                 285         

<210>   1502
<211>   286
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   1502
Met Ser Phe Gly Thr Val Leu Thr Ala Met Val Thr Pro Phe Asp Asp 
                5                   10                  15      

Gln Gly Met Ile Asn Tyr Asp Gln Leu Glu Val Leu Ile Asn His Leu 
            20                  25                  30          

Ile Glu Asn Gly Ser Asp Gly Leu Val Val Gly Gly Thr Thr Gly Glu 
        35                  40                  45              

Ser Ala Thr Leu Ser Ile Glu Glu Lys Ala Ala Leu Tyr Gln Gln Ser 
    50                  55                  60                  

Val Arg Ile Ala Asp Gly Arg Val Pro Ile Ile Ala Gly Thr Gly Met 
65                  70                  75                  80  

Asn Asp Thr Tyr Ala Thr Ala Glu Leu Thr Ile Arg Ala Glu Arg Val 
                85                  90                  95      

Gly Val Asp Gly Ile Met Leu Val Ala Pro Tyr Tyr Asn Lys Pro Ser 
            100                 105                 110         

Gln Lys Gly Leu Tyr Glu His Phe Gln Thr Ile Ala Glu Lys Thr Ser 
        115                 120                 125             

Leu Pro Val Met Val Tyr Asn Val Pro Gly Arg Thr Ala Val Asn Ile 
    130                 135                 140                 

Leu Pro Glu Thr Val Ile Glu Leu Ala Lys Ile Glu Asn Ile Thr Ser 
145                 150                 155                 160 

Val Lys Glu Ala Ser Gly Asn Leu Asp Gln Val Thr Met Ile Val Ala 
                165                 170                 175     

Asn Thr Pro Asp Asp Phe Thr Val Tyr Ser Gly Asp Asp Ser Leu Thr 
            180                 185                 190         

Leu Pro Ser Leu Ala Val Gly Ala Asp Gly Ile Val Ser Val Ser Ser 
        195                 200                 205             

His Ile Ile Gly Lys His Met Gln Gln Met Val Arg Tyr Tyr Lys Asp 
    210                 215                 220                 

Gly Gln Val Gly Glu Ala Ala Leu Leu His Gln Lys Leu Leu Pro Ile 
225                 230                 235                 240 

Met Arg Gly Met Phe Ile Ala Pro Ser Pro Ala Pro Val Lys Thr Ala 
                245                 250                 255     

Leu Asp Met Thr Gly Leu Asp Val Gly Gly Val Arg Leu Pro Leu Val 
            260                 265                 270         

Pro Leu Thr Glu Glu Glu Arg Lys Thr Leu Glu Ser Ile Val 
        275                 280                 285     

<210>   1503
<211>   289
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   1503
Met Asn Phe Gly Asn Ile Ala Thr Ala Met Val Thr Pro Phe Asp Lys 
                5                   10                  15      

Asn Glu Asn Ile Asp Phe Gln Lys Leu Ser Lys Leu Ile Asp Tyr Leu 
            20                  25                  30          

Leu Asn Asn Gly Thr Asp Ser Leu Val Val Ala Gly Thr Thr Gly Glu 
        35                  40                  45              

Ser Pro Thr Leu Ser Glu Glu Glu Lys Val Ala Leu Ile Gln Tyr Ser 
    50                  55                  60                  

Val Lys Glu Ala Ala Gly Arg Ala Pro Ile Ile Ala Gly Thr Gly Ser 
65                  70                  75                  80  

Asn Asn Thr Lys Ala Ser Ile Lys Leu Thr Lys Lys Ala Glu Glu Ala 
                85                  90                  95      

Gly Ala Asp Ala Val Met Leu Val Thr Pro Tyr Tyr Asn Lys Pro Ser 
            100                 105                 110         

Gln Glu Gly Met Tyr Arg His Phe Arg Ala Ile Ala Glu Glu Thr Ser 
        115                 120                 125             

Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Ala Ala Ser Leu 
    130                 135                 140                 

Ala Pro Glu Thr Thr Ile Arg Leu Ala Glu Ile Pro Asn Ile Ile Ala 
145                 150                 155                 160 

Ile Lys Glu Ala Ser Gly Asp Leu Asp Ala Ile Thr Lys Ile Val Ala 
                165                 170                 175     

Glu Thr Pro Glu Asp Phe Ala Val Tyr Ser Gly Asp Asp Ser Leu Thr 
            180                 185                 190         

Leu Pro Ala Leu Ser Val Gly Ala Arg Gly Ile Val Ser Val Ala Ser 
        195                 200                 205             

His Ile Ile Gly Pro Glu Met Gln Glu Met Ile Lys His Tyr Thr Glu 
    210                 215                 220                 

Gly Asn Thr Ala Gln Ala Ala Leu Ile His Gln Lys Leu Leu Pro Leu 
225                 230                 235                 240 

Met Lys Gly Leu Phe Ala Ala Pro Asn Pro Ser Pro Leu Lys Thr Ala 
                245                 250                 255     

Leu Gln Leu Lys Gly Leu Asp Val Gly Ser Val Arg Leu Pro Leu Ile 
            260                 265                 270         

Pro Leu Asn Glu Asp Glu Arg Leu Arg Leu Ser Ser Leu Met Asn Gly 
        275                 280                 285             

Leu 
    

<210>   1504
<211>   298
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1497

<400>   1504
Met Arg Met Asp Phe Gly Ser Leu Ile Thr Ala Met Val Thr Pro Phe 
                5                   10                  15      

Asp Ala Thr Gly Ala Leu Asp Glu Gly Arg Leu Arg Arg Leu Val Asp 
            20                  25                  30          

His Leu Ile Glu Thr Gly Thr Thr Ala Val Val Val Cys Gly Thr Thr 
        35                  40                  45              

Gly Glu Ser Pro Thr Leu Ser His Ala Glu Lys Leu Arg Leu Phe Asp 
    50                  55                  60                  

Ala Thr Leu Arg Ala Val Asp Gly Arg Ile Pro Val Ile Ala Gly Thr 
65                  70                  75                  80  

Gly Thr Asn Ser Thr Lys Asp Ser Ile Glu Leu Thr Leu Glu Ala Ala 
                85                  90                  95      

Arg Leu Gly Val Gln Ala Val Met Leu Val Thr Pro Tyr Tyr Asn Arg 
            100                 105                 110         

Pro Ser Gln Glu Gly Leu Tyr Met His Phe Ala Ser Ile Ala Glu Ser 
        115                 120                 125             

Thr Thr Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Gly Val 
    130                 135                 140                 

Asn Leu Asn Pro Gln Thr Ala Leu Gln Leu Ala Ala Ile Pro Asn Val 
145                 150                 155                 160 

Val Ala Leu Lys Glu Ala Ser Gly Asp Phe Ser Gln Ile Leu Arg Ile 
                165                 170                 175     

Ala Ala Glu Lys Pro Asp Asp Phe Leu Leu Tyr Ser Gly Asp Asp Lys 
            180                 185                 190         

Phe Thr Leu Pro Met Leu Ala Ile Gly Ala Ala Gly Val Val Ser Val 
        195                 200                 205             

Ala Gly His Val Val Gly Arg Gln Ile Arg Thr Met Met Asp Leu Phe 
    210                 215                 220                 

Trp Gln Gly Gln Val Asp Glu Ala Ala Tyr Trp Ser Ala Arg Leu Leu 
225                 230                 235                 240 

Pro Ile Phe Glu Ala Met Phe Met Glu Ala Ser Pro Ala Pro Val Lys 
                245                 250                 255     

Glu Ala Leu Ser Ile Leu Gly Ile Asp Val Gly Ser Val Arg Ser Pro 
            260                 265                 270         

Leu Val Pro Ala Ser Lys Ala Leu Arg Glu His Leu Tyr Thr Leu Leu 
        275                 280                 285             

Asn Ala Leu Gly Val Ile Glu Pro Ser Ala 
    290                 295             

<210>   1505
<211>   298
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1497

<400>   1505
Met Arg Met Asp Phe Gly Ser Leu Ile Thr Ala Met Val Thr Pro Phe 
                5                   10                  15      

Asp Ala Thr Gly Ala Leu Asp Glu Gly Arg Leu Arg Arg Leu Val Asp 
            20                  25                  30          

His Leu Ile Glu Thr Gly Thr Thr Ala Val Val Val Cys Gly Thr Thr 
        35                  40                  45              

Gly Glu Ser Pro Thr Leu Ser His Ala Glu Lys Leu Arg Leu Phe Asp 
    50                  55                  60                  

Ala Thr Leu Arg Ala Val Asp Gly Arg Ile Pro Val Ile Ala Gly Thr 
65                  70                  75                  80  

Gly Thr Asn Ser Thr Lys Asp Ser Ile Glu Leu Thr Leu Glu Ala Ala 
                85                  90                  95      

Arg Leu Gly Val Gln Ala Val Met Leu Val Thr Pro Tyr Tyr Asn Arg 
            100                 105                 110         

Pro Ser Gln Glu Gly Leu Tyr Met His Phe Ala Ser Ile Ala Glu Ser 
        115                 120                 125             

Thr Thr Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Gly Val 
    130                 135                 140                 

Asn Leu Gln Pro Gln Thr Ala Leu Gln Leu Ala Ala Ile Pro Asn Val 
145                 150                 155                 160 

Val Ala Leu Lys Glu Ala Ser Gly Asp Phe Ser Gln Ile Leu Arg Ile 
                165                 170                 175     

Ala Ala Glu Lys Pro Asp Asp Phe Leu Leu Tyr Ser Gly Asp Asp Lys 
            180                 185                 190         

Phe Thr Leu Pro Met Leu Ala Ile Gly Ala Ala Gly Val Val Ser Val 
        195                 200                 205             

Ala Gly His Val Val Gly Arg Gln Ile Arg Thr Met Met Asp Leu Phe 
    210                 215                 220                 

Trp Gln Gly Gln Val Asp Glu Ala Ala Tyr Trp Ser Ala Arg Leu Leu 
225                 230                 235                 240 

Pro Ile Phe Glu Ala Met Phe Met Glu Ala Ser Pro Ala Pro Val Lys 
                245                 250                 255     

Glu Ala Leu Ser Ile Leu Gly Ile Asp Val Gly Ser Val Arg Ser Pro 
            260                 265                 270         

Leu Val Pro Ala Ser Lys Ala Ile Arg Glu His Leu Tyr Thr Leu Leu 
        275                 280                 285             

Asn Ala Leu Gly Val Ile Glu Pro Ser Ala 
    290                 295             

<210>   1506
<211>   298
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1497

<400>   1506
Met Arg Met Asp Phe Gly Ser Leu Ile Thr Ala Met Val Thr Pro Phe 
                5                   10                  15      

Asp Ala Thr Gly Ala Leu Asp Glu Gly Arg Leu Arg Arg Leu Val Asp 
            20                  25                  30          

His Leu Ile Glu Thr Gly Thr Thr Ala Val Val Val Cys Gly Thr Thr 
        35                  40                  45              

Gly Glu Ser Pro Thr Leu Ser His Ala Glu Lys Leu Arg Leu Phe Asp 
    50                  55                  60                  

Ala Thr Leu Arg Ala Val Asp Gly Arg Ile Pro Val Ile Ala Gly Thr 
65                  70                  75                  80  

Gly Thr Asn Ser Thr Lys Asp Ser Ile Glu Leu Thr Leu Glu Ala Ala 
                85                  90                  95      

Arg Leu Gly Val Gln Ala Val Met Leu Val Thr Pro Tyr Tyr Asn Arg 
            100                 105                 110         

Pro Ser Gln Glu Gly Leu Tyr Met His Phe Ala Ser Ile Ala Glu Ser 
        115                 120                 125             

Thr Thr Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Gly Val 
    130                 135                 140                 

Asn Leu Gln Pro Gln Thr Ala Leu Gln Leu Ala Ala Ile Pro Asn Val 
145                 150                 155                 160 

Val Ala Leu Lys Glu Ala Ser Gly Asp Phe Ser Gln Ile Leu Arg Ile 
                165                 170                 175     

Ala Ala Glu Lys Pro Asp Asp Phe Leu Leu Tyr Ser Gly Asp Asp Lys 
            180                 185                 190         

Phe Thr Leu Pro Met Leu Ala Ile Gly Ala Ala Gly Val Val Ser Val 
        195                 200                 205             

Ala Gly His Val Val Gly Arg Gln Ile Arg Thr Met Met Asp Leu Phe 
    210                 215                 220                 

Trp Gln Gly Gln Val Asp Asp Ala Ala Tyr Trp Ser Ala Arg Leu Leu 
225                 230                 235                 240 

Pro Ile Phe Glu Ala Met Phe Met Glu Ala Ser Pro Ala Pro Val Lys 
                245                 250                 255     

Glu Ala Leu Ser Ile Leu Gly Ile Asp Val Gly Ser Val Arg Ser Pro 
            260                 265                 270         

Leu Val Pro Ala Ser Lys Ala Leu Arg Glu His Leu Tyr Thr Leu Leu 
        275                 280                 285             

Asn Ala Leu Gly Val Ile Glu Pro Ser Ala 
    290                 295             

<210>   1507
<211>   298
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1497

<400>   1507
Met Arg Met Asp Phe Gly Ser Leu Ile Thr Ala Met Val Thr Pro Phe 
                5                   10                  15      

Asp Ala Thr Gly Ala Leu Asp Glu Gly Arg Leu Arg Arg Leu Val Asp 
            20                  25                  30          

His Leu Ile Glu Thr Gly Thr Thr Ala Val Val Val Cys Gly Thr Thr 
        35                  40                  45              

Gly Glu Ser Pro Thr Leu Ser His Ala Glu Lys Leu Arg Leu Phe Asp 
    50                  55                  60                  

Ala Thr Leu Arg Ala Val Asp Gly Arg Ile Pro Val Ile Ala Gly Thr 
65                  70                  75                  80  

Gly Thr Asn Ser Thr Lys Asp Ser Ile Glu Leu Thr Leu Glu Ala Ala 
                85                  90                  95      

Arg Leu Gly Val Gln Ala Val Met Leu Val Thr Pro Tyr Tyr Asn Arg 
            100                 105                 110         

Pro Ser Gln Glu Gly Leu Tyr Met His Phe Ala Ser Ile Ala Glu Ser 
        115                 120                 125             

Thr Thr Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Gly Val 
    130                 135                 140                 

Asn Leu Gln Pro Gln Thr Ala Leu Gln Leu Ala Ala Ile Pro Asn Val 
145                 150                 155                 160 

Val Ala Leu Lys Glu Ala Ser Gly Asp Phe Ser Gln Ile Leu Arg Ile 
                165                 170                 175     

Ala Ala Glu Lys Pro Asp Asp Phe Ile Leu Tyr Ser Gly Asp Asp Lys 
            180                 185                 190         

Phe Thr Leu Pro Met Leu Ala Ile Gly Ala Ala Gly Val Val Ser Val 
        195                 200                 205             

Ala Gly His Val Val Gly Arg Gln Ile Arg Thr Met Met Asp Leu Phe 
    210                 215                 220                 

Trp Gln Gly Gln Val Asp Glu Ala Ala Tyr Trp Ser Ala Arg Leu Leu 
225                 230                 235                 240 

Pro Ile Phe Glu Ala Met Phe Met Glu Ala Ser Pro Ala Pro Val Lys 
                245                 250                 255     

Glu Ala Leu Ser Ile Leu Gly Ile Asp Val Gly Ser Val Arg Ser Pro 
            260                 265                 270         

Leu Val Pro Ala Ser Lys Ala Leu Arg Glu His Leu Tyr Thr Leu Leu 
        275                 280                 285             

Asn Ala Leu Gly Val Ile Glu Pro Ser Ala 
    290                 295             

<210>   1508
<211>   298
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1497

<400>   1508
Met Arg Met Asp Phe Gly Ser Leu Ile Thr Ala Met Val Thr Pro Phe 
                5                   10                  15      

Asp Ala Thr Gly Ala Leu Asp Glu Gly Arg Leu Arg Arg Leu Val Asp 
            20                  25                  30          

His Leu Ile Glu Thr Gly Thr Thr Ala Val Val Val Cys Gly Thr Thr 
        35                  40                  45              

Gly Glu Ser Pro Thr Leu Ser His Ala Glu Lys Leu Lys Leu Phe Asp 
    50                  55                  60                  

Ala Thr Leu Arg Ala Val Asp Gly Arg Ile Pro Val Ile Ala Gly Thr 
65                  70                  75                  80  

Gly Thr Asn Ser Thr Lys Asp Ser Ile Glu Leu Thr Leu Glu Ala Ala 
                85                  90                  95      

Arg Leu Gly Val Gln Ala Val Met Leu Val Thr Pro Tyr Tyr Asn Arg 
            100                 105                 110         

Pro Ser Gln Glu Gly Leu Tyr Met His Phe Ala Ser Ile Ala Glu Ser 
        115                 120                 125             

Thr Thr Leu Pro Val Met Leu Tyr Asn Val Pro Gly Arg Thr Gly Val 
    130                 135                 140                 

Asn Leu Gln Pro Gln Thr Ala Leu Gln Leu Ala Ala Ile Pro Asn Val 
145                 150                 155                 160 

Val Ala Leu Lys Glu Ala Ser Gly Asp Phe Ser Gln Ile Leu Arg Ile 
                165                 170                 175     

Ala Ala Glu Lys Pro Asp Asp Phe Leu Leu Tyr Ser Gly Asp Asp Lys 
            180                 185                 190         

Phe Thr Leu Pro Met Leu Ala Ile Gly Ala Ala Gly Val Val Ser Val 
        195                 200                 205             

Ala Gly His Val Val Gly Arg Gln Ile Arg Thr Met Met Asp Leu Phe 
    210                 215                 220                 

Trp Gln Gly Gln Val Asp Glu Ala Ala Tyr Trp Ser Ala Arg Leu Leu 
225                 230                 235                 240 

Pro Ile Phe Glu Ala Met Phe Met Glu Ala Ser Pro Ala Pro Val Lys 
                245                 250                 255     

Glu Ala Leu Ser Ile Leu Gly Ile Asp Val Gly Ser Val Arg Ser Pro 
            260                 265                 270         

Leu Val Pro Ala Ser Lys Ala Leu Arg Glu His Leu Tyr Thr Leu Leu 
        275                 280                 285             

Asn Ala Leu Gly Val Ile Glu Pro Ser Ala 
    290                 295             

<210>   1509
<211>   897
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1498

<400>   1509
atgcgtatgg attttggaag cctgatcacg gcgatggtca cgccctttga tgccacgggt       60

gcgctcgacg aggggcgcct gcggcggctg gtggaccacc tgatcgaaac gggcacgacc      120

gcggtcgtgg tgtgcgggac gacgggggaa tccccaaccc tgagccacgc ggaaaagctg      180

cgcctgttcg acgccaccct ccgggcggtg gacggccgga ttccggtgat cgcgggcacg      240

ggcaccaatt cgaccaagga ttccattgag ctcacgctcg aggccgctcg tctcggcgtg      300

caggccgtca tgctcgtgac gccgtattac aaccgcccgt ctcaggaagg gctgtacatg      360

cacttcgcca gcatcgcgga gtcgaccacc ttgccggtca tgttgtacaa cgtgccgggg      420

cggacggggg tcaatctgaa tccgcagacc gcgcttcagc tcgcggccat cccgaacgtc      480

gtcgcgctca aggaggcgag cggcgacttt tcgcagatcc tccgcatcgc ggccgagaag      540

ccggacgact ttcttctcta cagcggggac gacaagttca cgttgccgat gctcgccatc      600

ggagcggcgg gcgtcgtgag cgtcgcgggc cacgtcgtcg gtcggcagat ccgcacgatg      660

atggatctct tctggcaagg gcaggtggac gaggcggcgt actggagcgc gcggctgttg      720

cccatcttcg aggccatgtt tatggaggcc agcccggcgc cggtgaagga ggcgctttcc      780

atcctcggca tcgacgtggg ctccgtccgc tcgccgcttg tgccggcctc caaggcgctc      840

cgcgagcacc tgtacacgct tctgaacgcg ctcggggtca tcgagccaag cgcatga         897


<210>   1510
<211>   897
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1498

<400>   1510
atgcgtatgg attttggaag cctgatcacg gcgatggtca cgccctttga tgccacgggt       60

gcgctcgacg aggggcgcct gcggcggctg gtggaccacc tgatcgaaac gggcacgacc      120

gcggtcgtgg tgtgcgggac gacgggggaa tccccaaccc tgagccacgc ggaaaagctg      180

cgcctgttcg acgccaccct ccgggcggtg gacggccgga ttccggtgat cgcgggcacg      240

ggcaccaatt cgaccaagga ttccattgag ctcacgctcg aggccgctcg tctcggcgtg      300

caggccgtca tgctcgtgac gccgtattac aaccgcccgt ctcaggaagg gctgtacatg      360

cacttcgcca gcatcgcgga gtcgaccacc ttgccggtca tgttgtacaa cgtgccgggg      420

cggacggggg tcaatctgca gccgcagacc gcgcttcagc tcgcggccat cccgaacgtc      480

gtcgcgctca aggaggcgag cggcgacttt tcgcagatcc tccgcatcgc ggccgagaag      540

ccggacgact ttcttctcta cagcggggac gacaagttca cgttgccgat gctcgccatc      600

ggagcggcgg gcgtcgtgag cgtcgcgggc cacgtcgtcg gtcggcagat ccgcacgatg      660

atggatctct tctggcaagg gcaggtggac gaggcggcgt actggagcgc gcggctgttg      720

cccatcttcg aggccatgtt tatggaggcc agcccggcgc cggtgaagga ggcgctttcc      780

atcctcggca tcgacgtggg ctccgtccgc tcgccgcttg tgccggcctc caaggcgatt      840

cgcgagcacc tgtacacgct tctgaacgcg ctcggggtca tcgagccaag cgcatga         897


<210>   1511
<211>   897
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1498

<400>   1511
atgcgtatgg attttggaag cctgatcacg gcgatggtca cgccctttga tgccacgggt       60

gcgctcgacg aggggcgcct gcggcggctg gtggaccacc tgatcgaaac gggcacgacc      120

gcggtcgtgg tgtgcgggac gacgggggaa tccccaaccc tgagccacgc ggaaaagctg      180

cgcctgttcg acgccaccct ccgggcggtg gacggccgga ttccggtgat cgcgggcacg      240

ggcaccaatt cgaccaagga ttccattgag ctcacgctcg aggccgctcg tctcggcgtg      300

caggccgtca tgctcgtgac gccgtattac aaccgcccgt ctcaggaagg gctgtacatg      360

cacttcgcca gcatcgcgga gtcgaccacc ttgccggtca tgttgtacaa cgtgccgggg      420

cggacggggg tcaatctgca gccgcagacc gcgcttcagc tcgcggccat cccgaacgtc      480

gtcgcgctca aggaggcgag cggcgacttt tcgcagatcc tccgcatcgc ggccgagaag      540

ccggacgact ttcttctcta cagcggggac gacaagttca cgttgccgat gctcgccatc      600

ggagcggcgg gcgtcgtgag cgtcgcgggc cacgtcgtcg gtcggcagat ccgcacgatg      660

atggatctct tctggcaagg gcaggtggac gatgcggcgt actggagcgc gcggctgttg      720

cccatcttcg aggccatgtt tatggaggcc agcccggcgc cggtgaagga ggcgctttcc      780

atcctcggca tcgacgtggg ctccgtccgc tcgccgcttg tgccggcctc caaggcgctc      840

cgcgagcacc tgtacacgct tctgaacgcg ctcggggtca tcgagccaag cgcatga         897


<210>   1512
<211>   897
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1498

<400>   1512
atgcgtatgg attttggaag cctgatcacg gcgatggtca cgccctttga tgccacgggt       60

gcgctcgacg aggggcgcct gcggcggctg gtggaccacc tgatcgaaac gggcacgacc      120

gcggtcgtgg tgtgcgggac gacgggggaa tccccaaccc tgagccacgc ggaaaagctg      180

cgcctgttcg acgccaccct ccgggcggtg gacggccgga ttccggtgat cgcgggcacg      240

ggcaccaatt cgaccaagga ttccattgag ctcacgctcg aggccgctcg tctcggcgtg      300

caggccgtca tgctcgtgac gccgtattac aaccgcccgt ctcaggaagg gctgtacatg      360

cacttcgcca gcatcgcgga gtcgaccacc ttgccggtca tgttgtacaa cgtgccgggg      420

cggacggggg tcaatctgca gccgcagacc gcgcttcagc tcgcggccat cccgaacgtc      480

gtcgcgctca aggaggcgag cggcgacttt tcgcagatcc tccgcatcgc ggccgagaag      540

ccggacgact ttattctcta cagcggggac gacaagttca cgttgccgat gctcgccatc      600

ggagcggcgg gcgtcgtgag cgtcgcgggc cacgtcgtcg gtcggcagat ccgcacgatg      660

atggatctct tctggcaagg gcaggtggac gaggcggcgt actggagcgc gcggctgttg      720

cccatcttcg aggccatgtt tatggaggcc agcccggcgc cggtgaagga ggcgctttcc      780

atcctcggca tcgacgtggg ctccgtccgc tcgccgcttg tgccggcctc caaggcgctc      840

cgcgagcacc tgtacacgct tctgaacgcg ctcggggtca tcgagccaag cgcatga         897


<210>   1513
<211>   897
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1498

<400>   1513
atgcgtatgg attttggaag cctgatcacg gcgatggtca cgccctttga tgccacgggt       60

gcgctcgacg aggggcgcct gcggcggctg gtggaccacc tgatcgaaac gggcacgacc      120

gcggtcgtgg tgtgcgggac gacgggggaa tccccaaccc tgagccacgc ggaaaagctg      180

aaactgttcg acgccaccct ccgggcggtg gacggccgga ttccggtgat cgcgggcacg      240

ggcaccaatt cgaccaagga ttccattgag ctcacgctcg aggccgctcg tctcggcgtg      300

caggccgtca tgctcgtgac gccgtattac aaccgcccgt ctcaggaagg gctgtacatg      360

cacttcgcca gcatcgcgga gtcgaccacc ttgccggtca tgttgtacaa cgtgccgggg      420

cggacggggg tcaatctgca gccgcagacc gcgcttcagc tcgcggccat cccgaacgtc      480

gtcgcgctca aggaggcgag cggcgacttt tcgcagatcc tccgcatcgc ggccgagaag      540

ccggacgact ttcttctcta cagcggggac gacaagttca cgttgccgat gctcgccatc      600

ggagcggcgg gcgtcgtgag cgtcgcgggc cacgtcgtcg gtcggcagat ccgcacgatg      660

atggatctct tctggcaagg gcaggtggac gaggcggcgt actggagcgc gcggctgttg      720

cccatcttcg aggccatgtt tatggaggcc agcccggcgc cggtgaagga ggcgctttcc      780

atcctcggca tcgacgtggg ctccgtccgc tcgccgcttg tgccggcctc caaggcgctc      840

cgcgagcacc tgtacacgct tctgaacgcg ctcggggtca tcgagccaag cgcatga         897


<210>   1514
<211>   480
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1514
Met Arg Arg Leu Gln Asn Tyr Val Asn Gly Thr Trp Val Glu Val Glu 
                5                   10                  15      

Ser Glu His Ala Val Pro Val Tyr Asn Pro Ala Thr Gly Glu Val Ile 
            20                  25                  30          

Ala Glu Thr Pro Leu Ser Thr His Val Asp Val Ala Arg Ala Val Glu 
        35                  40                  45              

Gly Ala Lys Arg Ala Phe Ala Ser Trp Ser Arg Val Pro Val Val Lys 
    50                  55                  60                  

Arg Ala Arg Val Val Phe Asp Phe Leu Ala Lys Leu Lys Ala Glu Arg 
65                  70                  75                  80  

Asp Ala Ile Ala Lys Met Ile Thr Thr Glu His Gly Lys Ser Tyr Leu 
                85                  90                  95      

Asp Ala Gln Ala Glu Val Asp Arg Gly Ile Glu Gly Ile Glu His Ala 
            100                 105                 110         

Leu Ser Ala Pro Thr Leu Met Met Gly Glu Ser Leu Ala Glu Val Ser 
        115                 120                 125             

Glu Gly Leu Glu Gln Thr Tyr Tyr Arg Tyr Pro Leu Gly Val Val Ala 
    130                 135                 140                 

Ser Ile Thr Pro Phe Asn Phe Pro Ala Met Ile Pro Leu Trp Val Met 
145                 150                 155                 160 

Gly Trp Ala Val Val Thr Gly Asn Ala Leu Ile Leu Lys Pro Ser Glu 
                165                 170                 175     

Gln Thr Pro Met Thr Thr Leu Arg Leu Val Glu Met Phe His Glu Ala 
            180                 185                 190         

Gly Leu Pro Pro Gly Val Leu Gln Ala Val Asn Gly Gly Lys Glu Ala 
        195                 200                 205             

Val Asp Ala Ile Leu Ser His Pro Glu Ile Val Ala Val Asn Phe Thr 
    210                 215                 220                 

Gly Ser Thr Arg Thr Ala Ala Tyr Val Tyr Glu Thr Ala Ala Arg His 
225                 230                 235                 240 

His Lys Arg Val Gln Ala Phe Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Leu Glu Asp Ala Val Leu Glu Pro Thr Ile Asp Gly Ile Leu Arg Ala 
            260                 265                 270         

Ala Phe His Asn Gly Gly Gln Arg Cys Met Ala Thr Ser Val Val Val 
        275                 280                 285             

Ala Val Gly Ser Val Ala Asp Glu Val Val Glu Arg Leu Ala Glu Gly 
    290                 295                 300                 

Ala Arg Arg Met Lys Ile Gly His Gly Phe Glu Glu Gly Val Asp Val 
305                 310                 315                 320 

Thr Pro Leu Ile Arg Lys Glu His Arg Asp Arg Val Arg Ala Tyr Val 
                325                 330                 335     

Asp Glu Ala Ala Met Ser Ala Arg Leu Val Val Asp Gly Arg Pro Ala 
            340                 345                 350         

Ile Asp Glu His Pro Glu Gly Phe Tyr Leu Gly Pro Cys Leu Leu Asp 
        355                 360                 365             

Gly Val Thr Pro Glu Met Arg Val Trp Gln Glu Glu Leu Phe Gly Pro 
    370                 375                 380                 

Val Leu Ser Val Val Arg Ala Arg Asp Leu Asp Glu Ala Ile Ala Ile 
385                 390                 395                 400 

Ala Asn Arg Ser Arg Tyr Ala Asn Gly Ala Ile Leu Tyr Thr Gln Ser 
                405                 410                 415     

Gly Lys Ala Ala Gln Val Phe Arg Asp Arg Ile Asp Ala Gly Met Val 
            420                 425                 430         

Gly Ile Asn Val Asn Val Pro Leu Pro Val Ala Phe Phe Pro Phe Gly 
        435                 440                 445             

Gly His Lys Asp Ser Phe Tyr Gly Val Thr Gly Glu Asn Gly Lys Glu 
    450                 455                 460                 

Leu Val Gln Phe Phe Thr Arg Arg Lys Val Val Ser Thr Arg Trp Phe 
465                 470                 475                 480 

<210>   1515
<211>   1443
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1515
atgcgccgtc tccaaaacta tgtgaatgga acttgggtgg aagttgagag cgaacacgcc       60

gtaccggtgt acaatcccgc gactggggaa gtcatcgccg agacgccgct ttcgacgcac      120

gtcgatgtgg cgcgggccgt ggagggcgcg aagcgggcgt ttgcgtcgtg gagccgggtg      180

cccgtcgtga agcgggcccg ggtggtgttc gacttcttgg cgaagctgaa ggcggagcga      240

gacgccatcg ccaagatgat cacgacggag cacggaaaga gctacctgga tgcgcaggcc      300

gaggtggatc gcggcatcga gggcatcgaa cacgcgctgt ccgcgcccac gctgatgatg      360

ggcgaatcgc tcgccgaggt gtcggagggg ctggagcaga cgtactaccg ctatcccttg      420

ggcgtggtcg ccagcatcac gccgttcaac tttccggcca tgatcccctt gtgggtgatg      480

gggtgggcgg tcgtcaccgg caacgcgctg attttgaagc cgtccgagca gacgccgatg      540

accacgcttc gcctggtgga gatgttccac gaagcgggac tgcccccggg cgtgcttcag      600

gcggtcaacg gcggcaagga agccgtggac gccatcctgt cccatcccga gattgtcgcc      660

gtgaacttca cgggttcgac gaggacggcc gcctatgtgt atgagacggc tgcgcgccac      720

cacaagcggg tgcaggcgtt cgcgggtgcg aagaaccacg ccattgtgct ggaggacgcc      780

gtgctcgagc cgaccatcga cggtatcctg cgcgccgcgt tccacaacgg cggccagcgc      840

tgcatggcca cctccgtcgt cgtggccgtc ggctcggtgg cggatgaagt cgtcgagcgg      900

ctggcggagg gcgcgcggcg catgaagatt ggccacggct ttgaggaagg tgtcgacgtc      960

acgccgctca ttcggaagga acatcgcgat cgcgtccgcg cgtacgtcga cgaggccgcc     1020

atgtccgccc ggctcgtggt ggacggacgg ccagccatcg acgaacatcc cgaagggttt     1080

tatctcggcc cgtgcctgct cgatggcgtg acgcccgaga tgcgcgtctg gcaggaggag     1140

ttgttcggcc ccgtgctctc cgtggtgcgg gcgcgcgatc tcgacgaggc catcgccatc     1200

gcgaatcgct cccgctacgc gaacggcgcc atcctgtaca cgcagagcgg caaggccgca     1260

caggtgtttc gcgatcgaat cgacgcaggc atggtcggca tcaacgtcaa cgtgcctctg     1320

cctgtggcct tcttcccgtt cggaggacac aaggactcct tctacggcgt gacgggcgag     1380

aacggcaagg agctggttca gtttttcacg cgaaggaagg tcgtctcgac gcgttggttt     1440

tga                                                                   1443


<210>   1516
<211>   481
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   1516
Ile Lys Arg Val Lys Asn His Ile Asn Gly Glu Trp Val Glu Ser Thr 
                5                   10                  15      

Gly Thr Glu Val Glu Ala Val Pro Asn Pro Ala Thr Gly Lys Ile Ile 
            20                  25                  30          

Ala Tyr Val Pro Leu Ser Pro Lys Glu Asp Val Glu Arg Ala Val Glu 
        35                  40                  45              

Ala Ala Lys Asn Ala Tyr Glu Thr Trp Ser Lys Val Pro Val Pro Asn 
    50                  55                  60                  

Arg Ser Arg Met Leu Tyr Lys Tyr Leu Gln Leu Leu Gln Glu Asn Lys 
65                  70                  75                  80  

Asp Glu Leu Ser Lys Ile Ile Thr Leu Glu Asn Gly Lys Thr Leu Lys 
                85                  90                  95      

Asp Ala Ser Gly Glu Val Gln Arg Gly Ile Glu Ala Val Glu Leu Ala 
            100                 105                 110         

Thr Ser Ala Pro Asn Leu Met Met Gly Gln Ala Leu Pro Asn Ile Ala 
        115                 120                 125             

Gly Gly Ile Asp Gly Ser Ile Trp Arg Tyr Pro Leu Gly Val Val Ala 
    130                 135                 140                 

Gly Ile Thr Pro Phe Asn Phe Pro Met Met Ile Pro Leu Trp Met Phe 
145                 150                 155                 160 

Pro Leu Ala Ile Ala Cys Gly Asn Thr Phe Val Leu Lys Thr Ser Glu 
                165                 170                 175     

Arg Thr Pro Leu Leu Ala Glu Arg Leu Val Glu Leu Phe Tyr Glu Ala 
            180                 185                 190         

Gly Phe Pro Lys Gly Val Leu Asn Leu Val Gln Gly Gly Lys Glu Val 
        195                 200                 205             

Val Asn Ser Ile Leu Glu Asn Lys Glu Ile Gln Ala Val Ser Phe Val 
    210                 215                 220                 

Gly Ser Glu Pro Val Ala Arg Tyr Val Tyr Glu Thr Gly Thr Lys Tyr 
225                 230                 235                 240 

Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Met Pro Asp Cys Asn Leu Glu Lys Thr Val Gln Gly Val Ile Gly Ser 
            260                 265                 270         

Ala Phe Gly Ser Ser Gly Glu Arg Cys Met Ala Cys Ser Val Val Ala 
        275                 280                 285             

Val Leu Asp Glu Ile Ala Asp Glu Phe Ile Asp Ala Leu Val Ser Glu 
    290                 295                 300                 

Thr Arg Lys Leu Lys Val Gly Asp Gly Phe His Glu Glu Asn Tyr Val 
305                 310                 315                 320 

Gly Pro Leu Ile Arg Glu Ser His Lys Glu Arg Val Ile Gly Tyr Ile 
                325                 330                 335     

Asn Ser Gly Val Ala Asp Gly Ala Ser Leu Leu Val Asp Gly Arg Gln 
            340                 345                 350         

Ile Lys Glu Asp Val Glu Gly Gly Tyr Phe Val Gly Ala Thr Ile Phe 
        355                 360                 365             

Asp Gly Val Asn Gln Asn Met Lys Ile Trp Gln Asp Glu Ile Phe Ala 
    370                 375                 380                 

Pro Val Leu Ser Ile Val Arg Val Arg Asp Leu Glu Glu Gly Ile Gln 
385                 390                 395                 400 

Leu Thr Asn Gln Ser Lys Phe Ala Asn Gly Ala Val Ile Tyr Thr Ser 
                405                 410                 415     

Ser Gly Lys His Ala Gln Thr Phe Arg Asp His Ile Asp Ala Gly Met 
            420                 425                 430         

Ile Gly Val Asn Val Asn Val Pro Ala Pro Met Ala Phe Phe Ala Phe 
        435                 440                 445             

Ala Gly Asn Lys Ala Ser Phe Tyr Gly Asp Leu Gly Thr Asn Gly Lys 
    450                 455                 460                 

Asp Gly Val Gln Phe Tyr Thr Arg Lys Lys Val Val Thr Glu Arg Trp 
465                 470                 475                 480 

Phe 
    

<210>   1517
<211>   480
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   1517
Val Lys Thr Val Lys Asn Trp Ile Asp Gly Ala Trp Val Glu Ala Ser 
                5                   10                  15      

Thr Ala Asp Thr Glu Val Val Pro Asn Pro Ala Thr Gly Glu Ala Ile 
            20                  25                  30          

Ala Tyr Val Pro Leu Ser Gly Glu Arg Asp Val Glu Gln Ala Val Ala 
        35                  40                  45              

Ser Ala Lys Arg Ala Tyr Glu Thr Trp Lys Thr Val Pro Val Pro Glu 
    50                  55                  60                  

Arg Thr Arg Tyr Met Phe Ala Tyr Leu Glu Gln Leu Lys Lys Asn Arg 
65                  70                  75                  80  

Glu Gln Leu Ala Gln Leu Ile Thr Leu Glu Asn Gly Lys Thr Ile Lys 
                85                  90                  95      

Asp Ala Arg Gly Glu Val Gln Arg Gly Ile Glu Cys Val Glu Leu Ala 
            100                 105                 110         

Thr Ser Thr Pro Thr Met Met Met Gly Asp Ala Leu Pro Asp Ile Ala 
        115                 120                 125             

Ser Gly Ile Asp Gly Ser Ile Trp Arg Tyr Pro Leu Gly Val Val Ala 
    130                 135                 140                 

Gly Ile Thr Pro Phe Asn Phe Pro Met Met Val Pro Leu Trp Met Phe 
145                 150                 155                 160 

Pro Leu Ala Ile Ala Ala Gly Asn Thr Phe Val Leu Lys Thr Ser Glu 
                165                 170                 175     

Arg Thr Pro Leu Leu Ala Glu Gln Leu Val Ser Leu Met His Glu Val 
            180                 185                 190         

Gly Leu Pro Arg Gly Val Leu Asn Leu Val Asn Gly Gly Lys Ala Val 
        195                 200                 205             

Val Asn Gly Leu Leu Asn His Pro Asp Val Glu Ala Ile Ser Phe Val 
    210                 215                 220                 

Gly Ser Glu Pro Val Ala Arg Tyr Val Tyr Glu Thr Gly Thr Ala Asn 
225                 230                 235                 240 

Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn His Ala Val Val 
                245                 250                 255     

Leu Ala Asp Cys Glu Leu Asp Lys Thr Val Gln Gly Val Ile Gly Ala 
            260                 265                 270         

Ala Phe Ala Ser Ser Gly Glu Arg Cys Met Ala Cys Ser Val Val Ala 
        275                 280                 285             

Val Val Glu Glu Val Ala Asp Ala Phe Ile Glu Lys Leu Thr Ala Glu 
    290                 295                 300                 

Thr Lys Lys Leu Thr Val Gly Asn Gly Lys Asn Asp Glu His Phe Val 
305                 310                 315                 320 

Gly Pro Leu Ile Arg Gln Ser His Lys Asp Lys Val Val Lys Tyr Ile 
                325                 330                 335     

Glu Gln Gly Val Glu Gln Gly Ala Glu Leu Leu Val Asp Gly Arg Asn 
            340                 345                 350         

Ala Thr Ser Glu Glu Ala Gly Tyr Tyr Leu Gly Ala Thr Leu Phe Asp 
        355                 360                 365             

His Val Thr Pro Glu Met Thr Ile Trp Gln Glu Glu Leu Phe Ala Pro 
    370                 375                 380                 

Val Leu Ser Ile Val Arg Val Arg Asp Leu Glu Glu Ala Ile Ala Leu 
385                 390                 395                 400 

Thr Asn Arg Ser Arg Phe Ala Asn Gly Ala Val Ile Tyr Thr Ser Ser 
                405                 410                 415     

Gly Lys Ala Ala Gln His Phe Arg Asn Ala Ile Asp Ala Gly Met Val 
            420                 425                 430         

Gly Ile Asn Val Asn Val Pro Ala Pro Met Ala Phe Phe Ser Phe Ala 
        435                 440                 445             

Gly Asn Lys Ala Ser Phe Phe Gly Asp Leu Gly Thr Asn Gly Arg Asp 
    450                 455                 460                 

Gly Ile Gln Phe Tyr Thr Arg Lys Lys Val Val Thr Glu Arg Trp Phe 
465                 470                 475                 480 

<210>   1518
<211>   481
<212>   PRT
<213>   Bacillus anthracis str. Ames

<400>   1518
Ile Lys Arg Val Lys Asn His Ile Asn Gly Glu Trp Val Glu Ser Thr 
                5                   10                  15      

Gly Thr Glu Val Glu Ala Val Pro Asn Pro Ala Thr Gly Lys Ile Ile 
            20                  25                  30          

Ala Tyr Val Pro Leu Ser Pro Lys Glu Asp Val Glu Lys Ala Val Glu 
        35                  40                  45              

Ala Ala Lys Ala Ala Tyr Glu Thr Trp Ser Lys Val Pro Val Pro Asn 
    50                  55                  60                  

Arg Ser Arg Gln Leu Tyr Lys Tyr Leu Gln Leu Leu Gln Glu Asn Lys 
65                  70                  75                  80  

Glu Glu Leu Ala Lys Ile Ile Thr Leu Glu Asn Gly Lys Thr Leu Thr 
                85                  90                  95      

Asp Ala Thr Gly Glu Val Gln Arg Gly Ile Glu Ala Val Glu Leu Ala 
            100                 105                 110         

Thr Ser Ala Pro Asn Leu Met Met Gly Gln Ala Leu Pro Asn Ile Ala 
        115                 120                 125             

Ser Gly Ile Asp Gly Ser Ile Trp Arg Tyr Pro Ile Gly Val Val Ala 
    130                 135                 140                 

Gly Ile Thr Pro Phe Asn Phe Pro Met Met Ile Pro Leu Trp Met Phe 
145                 150                 155                 160 

Pro Leu Ala Ile Ala Cys Gly Asn Thr Phe Val Leu Lys Thr Ser Glu 
                165                 170                 175     

Arg Thr Pro Leu Leu Ala Glu Arg Leu Val Glu Leu Phe Tyr Glu Ala 
            180                 185                 190         

Gly Phe Pro Lys Gly Val Leu Asn Leu Val Gln Gly Gly Lys Asp Val 
        195                 200                 205             

Val Asn Ser Ile Leu Glu Asn Lys Asp Ile Gln Ala Val Ser Phe Val 
    210                 215                 220                 

Gly Ser Glu Pro Val Ala Arg Tyr Val Tyr Glu Thr Gly Thr Lys His 
225                 230                 235                 240 

Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Met Pro Asp Cys Asn Leu Glu Lys Thr Val Gln Gly Val Ile Gly Ser 
            260                 265                 270         

Ala Phe Ala Ser Ser Gly Glu Arg Cys Met Ala Cys Ser Val Val Ala 
        275                 280                 285             

Val Val Asp Glu Ile Ala Asp Glu Phe Ile Asp Val Leu Val Ala Glu 
    290                 295                 300                 

Thr Lys Lys Leu Lys Val Gly Asp Gly Phe His Glu Asp Asn Tyr Val 
305                 310                 315                 320 

Gly Pro Leu Ile Arg Glu Ser His Lys Glu Arg Val Leu Gly Tyr Ile 
                325                 330                 335     

Asn Ser Gly Val Ala Asp Gly Ala Thr Leu Leu Val Asp Gly Arg Lys 
            340                 345                 350         

Ile Lys Glu Glu Val Gly Glu Gly Tyr Phe Val Gly Ala Thr Ile Phe 
        355                 360                 365             

Asp Gly Val Asn Gln Glu Met Lys Ile Trp Gln Asp Glu Ile Phe Ala 
    370                 375                 380                 

Pro Val Leu Ser Ile Val Arg Val Lys Asp Leu Glu Glu Gly Ile Lys 
385                 390                 395                 400 

Leu Thr Asn Gln Ser Lys Phe Ala Asn Gly Ala Val Ile Tyr Thr Ser 
                405                 410                 415     

Asn Gly Lys His Ala Gln Thr Phe Arg Asp Asn Ile Asp Ala Gly Met 
            420                 425                 430         

Ile Gly Val Asn Val Asn Val Pro Ala Pro Met Ala Phe Phe Ala Phe 
        435                 440                 445             

Ala Gly Asn Lys Ala Ser Phe Phe Gly Asp Leu Gly Thr Asn Gly Thr 
    450                 455                 460                 

Asp Gly Val Gln Phe Tyr Thr Arg Lys Lys Val Val Thr Glu Arg Trp 
465                 470                 475                 480 

Phe 
    

<210>   1519
<211>   480
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   1519
Lys His Met Gln Asn Tyr Ile Asn Gly Lys Trp Val Asp Ala Lys Ser 
                5                   10                  15      

Gly Lys Gln Glu Val Ile Pro Asn Pro Ala Thr Gly Glu Thr Ile Ala 
            20                  25                  30          

Thr Val Thr Ile Ser Asp Val Glu Asp Val Asp Met Ala Val Ala Ala 
        35                  40                  45              

Ala Lys Glu Val Phe Pro Glu Trp Ser Asp Ile Pro Val Pro Asn Arg 
    50                  55                  60                  

Thr Arg Tyr Leu Leu Asp Tyr Trp Lys Leu Leu Gln Asp Asn Lys Glu 
65                  70                  75                  80  

Glu Leu Ala Lys Ile Ile Thr Leu Glu Asn Gly Lys Ser Leu Arg Asp 
                85                  90                  95      

Ala Gln Gly Glu Val Gln Arg Gly Ile Glu Val Val Glu Leu Ala Thr 
            100                 105                 110         

Ser Thr Pro Ser Met Met Met Gly Asp Ala Leu Pro Ser Ile Ala Lys 
        115                 120                 125             

Gly Ile Asp Gly Ser Ile Trp Arg Tyr Pro Leu Gly Val Val Ala Gly 
    130                 135                 140                 

Ile Thr Pro Phe Asn Phe Pro Met Met Val Pro Leu Trp Met Phe Pro 
145                 150                 155                 160 

Leu Ala Ile Ala Cys Gly Asn Thr Phe Val Leu Lys Thr Ser Glu Arg 
                165                 170                 175     

Thr Pro Ile Leu Ala Glu Arg Leu Val Glu Leu Phe Tyr Glu Ala Gly 
            180                 185                 190         

Phe Pro Lys Gly Val Leu Asn Leu Val His Gly Gly Lys Glu Val Val 
        195                 200                 205             

Asn Arg Phe Leu Thr His Pro Asp Ile Glu Ala Val Ser Phe Val Gly 
    210                 215                 220                 

Ser Glu Pro Val Ala Lys His Val Tyr Gln Thr Gly Thr Ala His Gly 
225                 230                 235                 240 

Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn His Ala Val Val Met 
                245                 250                 255     

Pro Asp Cys Asp Val Glu Lys Thr Ile Gln Gly Val Leu Gly Ala Ala 
            260                 265                 270         

Phe Gly Ser Ser Gly Glu Arg Cys Met Ala Cys Ser Val Val Ala Val 
        275                 280                 285             

Val Asp Asp Ile Ala Asp Glu Phe Leu Glu Lys Leu Val Lys Glu Thr 
    290                 295                 300                 

Lys Lys Leu Arg Val Gly Asp Gly Met Asp Asp Ser Asn Phe Ile Gly 
305                 310                 315                 320 

Pro Val Ile Arg Glu Ser His Lys Glu Arg Val Leu Ser Tyr Ile Asp 
                325                 330                 335     

Ser Gly Val Asp Glu Gly Ala His Leu Leu Val Asp Gly Arg Lys Ile 
            340                 345                 350         

Lys Glu Glu Thr Pro Asp Gly Tyr Tyr Val Gly Ala Thr Ile Phe Asp 
        355                 360                 365             

His Val Thr Gln Asp Met Lys Ile Trp Gln Asp Glu Ile Phe Ala Pro 
    370                 375                 380                 

Val Leu Ser Val Val Arg Val Ser Asp Leu Glu Glu Gly Ile Arg Val 
385                 390                 395                 400 

Thr Asn Gln Ser Lys Phe Ala Asn Gly Ala Val Ile Tyr Thr Asn Ser 
                405                 410                 415     

Gly Lys Ser Ala Gln Gln Phe Arg Asn Arg Ile Asp Ala Gly Met Ile 
            420                 425                 430         

Gly Val Asn Val Asn Val Pro Ala Pro Met Ala Phe Phe Ser Phe Ala 
        435                 440                 445             

Gly Asn Lys Ala Ser Phe Tyr Gly Asp Leu Gly Thr Asn Gly Lys Asp 
    450                 455                 460                 

Gly Val Gln Phe Tyr Thr Arg Lys Lys Val Val Thr Glu Arg Trp Phe 
465                 470                 475                 480 

<210>   1520
<211>   481
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   1520
Ile Lys Arg Val Lys Asn His Ile Asn Gly Glu Trp Val Glu Ser Thr 
                5                   10                  15      

Gly Thr Glu Val Glu Ala Val Pro Asn Pro Ala Thr Gly Lys Ile Ile 
            20                  25                  30          

Ala Tyr Val Pro Leu Ser Pro Lys Glu Asp Val Glu Lys Ala Val Glu 
        35                  40                  45              

Ala Ala Lys Ala Ala Phe Glu Thr Trp Ser Lys Val Pro Val Pro Asn 
    50                  55                  60                  

Arg Ser Arg Asn Leu Tyr Lys Tyr Leu Gln Leu Leu Gln Glu Asn Lys 
65                  70                  75                  80  

Asp Glu Leu Ala Lys Ile Ile Thr Leu Glu Asn Gly Lys Thr Leu Thr 
                85                  90                  95      

Asp Ala Thr Gly Glu Val Gln Arg Gly Ile Glu Ala Val Glu Leu Ala 
            100                 105                 110         

Thr Ser Thr Pro Asn Leu Met Met Gly Gln Ala Leu Pro Asn Ile Ala 
        115                 120                 125             

Ser Gly Ile Asp Gly Ser Ile Trp Arg Tyr Pro Ile Gly Val Val Ala 
    130                 135                 140                 

Gly Ile Thr Pro Phe Asn Phe Pro Met Met Ile Pro Leu Trp Met Phe 
145                 150                 155                 160 

Pro Leu Ala Ile Ala Cys Gly Asn Thr Phe Val Leu Lys Thr Ser Glu 
                165                 170                 175     

Arg Thr Pro Leu Leu Ala Glu Arg Leu Val Glu Leu Phe Tyr Glu Ala 
            180                 185                 190         

Gly Phe Pro Lys Gly Val Leu Asn Leu Val Gln Gly Gly Lys Asp Val 
        195                 200                 205             

Val Asn Ser Ile Leu Glu Asn Lys Asp Ile Gln Ala Val Ser Phe Val 
    210                 215                 220                 

Gly Ser Glu Pro Val Ala Arg Tyr Val Tyr Glu Thr Gly Thr Lys His 
225                 230                 235                 240 

Gly Lys Arg Val Gln Ala Leu Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Met Pro Asp Cys Asn Leu Glu Lys Thr Val Gln Gly Val Ile Gly Ser 
            260                 265                 270         

Ala Phe Ala Ser Ser Gly Glu Arg Cys Met Ala Cys Ser Val Val Ala 
        275                 280                 285             

Val Val Asp Glu Ile Ala Asp Glu Phe Ile Asp Val Leu Val Ala Glu 
    290                 295                 300                 

Thr Lys Lys Leu Lys Val Gly Asp Gly Phe Asn Glu Asp Asn Tyr Val 
305                 310                 315                 320 

Gly Pro Leu Ile Arg Glu Ser His Lys Glu Arg Val Leu Gly Tyr Ile 
                325                 330                 335     

Asn Ser Gly Val Ala Asp Gly Ala Thr Leu Leu Val Asp Gly Arg Lys 
            340                 345                 350         

Ile Asn Glu Glu Val Gly Glu Gly Tyr Phe Val Gly Ala Thr Ile Phe 
        355                 360                 365             

Asp Gly Val Asn Gln Glu Met Lys Ile Trp Gln Asp Glu Ile Phe Ala 
    370                 375                 380                 

Pro Val Leu Ser Ile Val Arg Val Lys Asp Leu Glu Glu Gly Ile Lys 
385                 390                 395                 400 

Leu Thr Asn Gln Ser Lys Phe Ala Asn Gly Ala Val Ile Tyr Thr Ser 
                405                 410                 415     

Asn Gly Lys His Ala Gln Thr Phe Arg Asp Asn Ile Asp Ala Gly Met 
            420                 425                 430         

Ile Gly Val Asn Val Asn Val Pro Ala Pro Met Ala Phe Phe Ala Phe 
        435                 440                 445             

Ala Gly Asn Lys Ala Ser Phe Phe Gly Asp Leu Ser Thr Asn Gly Thr 
    450                 455                 460                 

Asp Gly Val Gln Phe Tyr Thr Arg Lys Lys Val Val Thr Glu Arg Trp 
465                 470                 475                 480 

Phe 
    

<210>   1521
<211>   480
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1514

<400>   1521
Met Arg Arg Leu Gln Asn Tyr Val Asn Gly Thr Trp Val Glu Val Glu 
                5                   10                  15      

Ser Glu His Ala Val Pro Val Tyr Asn Pro Ala Thr Gly Glu Val Ile 
            20                  25                  30          

Ala Glu Thr Pro Leu Ser Thr His Val Asp Val Ala Arg Ala Val Glu 
        35                  40                  45              

Gly Ala Lys Arg Ala Phe Ala Ser Trp Ser Arg Val Pro Val Val Lys 
    50                  55                  60                  

Arg Ala Arg Val Val Phe Asp Phe Leu Ala Lys Leu Lys Ala Glu Arg 
65                  70                  75                  80  

Asp Ala Ile Ala Lys Met Ile Thr Thr Glu His Gly Lys Ser Tyr Leu 
                85                  90                  95      

Asp Ala Gln Ala Glu Val Asp Arg Gly Ile Glu Gly Ile Glu His Ala 
            100                 105                 110         

Leu Ser Ala Pro Thr Leu Met Met Gly Glu Ser Leu Ala Glu Val Ser 
        115                 120                 125             

Glu Gly Leu Glu Gln Thr Tyr Tyr Arg Tyr Pro Leu Gly Val Val Ala 
    130                 135                 140                 

Ser Ile Thr Pro Phe Asn Phe Pro Ala Met Ile Pro Leu Trp Val Met 
145                 150                 155                 160 

Gly Trp Ala Val Val Thr Gly Asn Ala Leu Ile Leu Lys Pro Ser Glu 
                165                 170                 175     

Gln Thr Pro Met Thr Thr Leu Arg Leu Val Glu Met Phe His Glu Ala 
            180                 185                 190         

Gly Leu Pro Pro Gly Val Leu Gln Ala Val Asn Gly Gly Lys Glu Ala 
        195                 200                 205             

Val Asp Ala Ile Leu Ser His Pro Glu Ile Val Ala Val Asn Phe Thr 
    210                 215                 220                 

Gly Ser Thr Arg Thr Ala Ala Tyr Val Tyr Glu Thr Ala Ala Arg His 
225                 230                 235                 240 

His Lys Arg Val Gln Ala Phe Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Leu Glu Asp Ala Val Leu Glu Pro Thr Ile Asp Gly Ile Leu Arg Ala 
            260                 265                 270         

Ala Phe His Asn Gly Gly Gln Arg Cys Met Ala Thr Ser Val Val Val 
        275                 280                 285             

Ala Val Gly Ser Val Ala Asp Glu Val Val Glu Arg Leu Ala Glu Gly 
    290                 295                 300                 

Ala Arg Arg Met Lys Ile Gly His Gly Phe Glu Glu Gly Val Asp Val 
305                 310                 315                 320 

Thr Pro Leu Ile Arg Lys Glu His Arg Asp Arg Val Arg Ala Tyr Val 
                325                 330                 335     

Asp Glu Ala Ala Met Ser Ala Arg Leu Val Val Asp Gly Arg Pro Ala 
            340                 345                 350         

Ile Asp Glu His Pro Glu Gly Phe Tyr Leu Gly Pro Cys Leu Leu Asp 
        355                 360                 365             

Gly Val Thr Pro Glu Met Lys Val Trp Gln Glu Glu Leu Phe Gly Pro 
    370                 375                 380                 

Val Leu Ser Val Val Arg Ala Arg Asp Leu Asp Glu Ala Ile Ala Ile 
385                 390                 395                 400 

Ala Asn Arg Ser Arg Tyr Ala Asn Gly Ala Ile Leu Tyr Thr Gln Ser 
                405                 410                 415     

Gly Lys Ala Ala Gln Val Phe Arg Asp Arg Ile Asp Ala Gly Met Val 
            420                 425                 430         

Gly Ile Asn Val Asn Val Pro Leu Pro Val Ala Phe Phe Pro Phe Gly 
        435                 440                 445             

Gly His Lys Asp Ser Phe Tyr Gly Val Thr Gly Glu Asn Gly Lys Glu 
    450                 455                 460                 

Leu Val Gln Phe Phe Thr Arg Arg Lys Val Val Ser Thr Arg Trp Phe 
465                 470                 475                 480 

<210>   1522
<211>   480
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1514

<400>   1522
Met Arg Arg Leu Gln Asn Tyr Val Asn Gly Thr Trp Val Glu Val Glu 
                5                   10                  15      

Ser Glu His Ala Val Pro Val Tyr Asn Pro Ala Thr Gly Glu Val Ile 
            20                  25                  30          

Ala Glu Thr Pro Leu Ser Thr His Val Asp Val Ala Arg Ala Val Glu 
        35                  40                  45              

Gly Ala Lys Arg Ala Phe Ala Ser Trp Ser Arg Val Pro Val Val Lys 
    50                  55                  60                  

Arg Ala Arg Val Val Phe Asp Phe Leu Ala Lys Leu Lys Ala Glu Arg 
65                  70                  75                  80  

Asp Ala Ile Ala Lys Met Ile Thr Thr Glu His Gly Lys Ser Tyr Leu 
                85                  90                  95      

Asp Ala Gln Ala Glu Val Asp Arg Gly Ile Glu Gly Ile Glu His Ala 
            100                 105                 110         

Leu Ser Ala Pro Thr Leu Met Met Gly Glu Ser Leu Ala Glu Val Ser 
        115                 120                 125             

Glu Gly Leu Glu Gln Thr Tyr Tyr Arg Tyr Pro Leu Gly Val Val Ala 
    130                 135                 140                 

Ser Ile Thr Pro Phe Asn Phe Pro Ala Met Ile Pro Leu Trp Val Met 
145                 150                 155                 160 

Gly Trp Ala Val Val Thr Gly Asn Ala Leu Ile Leu Lys Pro Ser Glu 
                165                 170                 175     

Gln Thr Pro Met Thr Thr Leu Arg Leu Val Glu Met Phe His Glu Ala 
            180                 185                 190         

Gly Leu Pro Pro Gly Val Leu Gln Ala Val Asn Gly Gly Lys Glu Ala 
        195                 200                 205             

Val Asp Ala Ile Leu Ser His Pro Glu Ile Val Ala Val Asn Phe Thr 
    210                 215                 220                 

Gly Ser Thr Arg Thr Ala Ala Tyr Val Tyr Glu Thr Ala Ala Arg His 
225                 230                 235                 240 

His Lys Arg Val Gln Ala Phe Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Leu Glu Asp Ala Val Leu Glu Pro Thr Ile Asp Gly Ile Leu Arg Ala 
            260                 265                 270         

Ala Phe His Asn Gly Gly Gln Arg Cys Met Ala Thr Ser Val Val Val 
        275                 280                 285             

Ala Val Gly Ser Val Ala Asp Glu Val Val Glu Arg Leu Ala Glu Gly 
    290                 295                 300                 

Ala Arg Arg Met Lys Ile Gly His Gly Phe Glu Glu Gly Val Glu Val 
305                 310                 315                 320 

Thr Pro Leu Ile Arg Lys Glu His Arg Asp Arg Val Arg Ala Tyr Val 
                325                 330                 335     

Asp Glu Ala Ala Met Ser Ala Arg Leu Val Val Asp Gly Arg Pro Ala 
            340                 345                 350         

Ile Asp Glu His Pro Glu Gly Phe Tyr Leu Gly Pro Cys Leu Leu Asp 
        355                 360                 365             

Gly Val Thr Pro Glu Met Arg Val Trp Gln Glu Glu Leu Phe Gly Pro 
    370                 375                 380                 

Val Leu Ser Val Val Arg Ala Arg Asp Leu Asp Glu Ala Ile Ala Ile 
385                 390                 395                 400 

Ala Asn Arg Ser Arg Tyr Ala Asn Gly Ala Ile Leu Tyr Thr Gln Ser 
                405                 410                 415     

Gly Lys Ala Ala Gln Val Phe Arg Asp Arg Ile Asp Ala Gly Met Val 
            420                 425                 430         

Gly Ile Asn Val Asn Val Pro Leu Pro Val Ala Phe Phe Pro Phe Gly 
        435                 440                 445             

Gly His Lys Asp Ser Phe Tyr Gly Val Thr Gly Glu Asn Gly Lys Glu 
    450                 455                 460                 

Leu Val Gln Phe Phe Thr Arg Arg Lys Val Val Ser Thr Arg Trp Phe 
465                 470                 475                 480 

<210>   1523
<211>   480
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1514

<400>   1523
Met Arg Arg Leu Gln Asn Tyr Val Asn Gly Thr Trp Val Glu Val Glu 
                5                   10                  15      

Ser Glu His Ala Val Pro Val Tyr Asn Pro Ala Thr Gly Glu Val Ile 
            20                  25                  30          

Ala Glu Thr Pro Leu Ser Thr His Val Asp Val Ala Arg Ala Val Glu 
        35                  40                  45              

Gly Ala Lys Arg Ala Phe Ala Ser Trp Ser Arg Val Pro Val Val Lys 
    50                  55                  60                  

Arg Ala Arg Val Val Phe Asp Phe Leu Ala Lys Leu Lys Ala Glu Arg 
65                  70                  75                  80  

Asp Ala Ile Ala Lys Met Ile Thr Thr Glu His Gly Lys Ser Tyr Leu 
                85                  90                  95      

Asp Ala Gln Ala Glu Val Asp Arg Gly Ile Glu Gly Ile Glu His Ala 
            100                 105                 110         

Leu Ser Ala Pro Thr Leu Met Met Gly Glu Ser Leu Ala Glu Val Ser 
        115                 120                 125             

Glu Gly Leu Glu Gln Thr Tyr Tyr Arg Tyr Pro Leu Gly Val Val Ala 
    130                 135                 140                 

Ser Ile Thr Pro Phe Asn Phe Pro Ala Met Ile Pro Leu Trp Val Met 
145                 150                 155                 160 

Gly Trp Ala Val Val Thr Gly Asn Ala Leu Ile Leu Lys Pro Ser Glu 
                165                 170                 175     

Gln Thr Pro Met Thr Thr Leu Arg Leu Val Glu Met Phe His Glu Ala 
            180                 185                 190         

Gly Leu Pro Pro Gly Val Leu Gln Ala Val Asn Gly Gly Lys Glu Ala 
        195                 200                 205             

Val Asp Ala Ile Leu Ser His Pro Glu Ile Val Ala Val Asn Phe Thr 
    210                 215                 220                 

Gly Ser Thr Arg Thr Ala Ala Tyr Val Tyr Glu Thr Ala Ala Arg His 
225                 230                 235                 240 

His Lys Arg Val Gln Ala Phe Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Leu Glu Asp Ala Ile Leu Glu Pro Thr Ile Asp Gly Ile Leu Arg Ala 
            260                 265                 270         

Ala Phe His Asn Gly Gly Gln Arg Cys Met Ala Thr Ser Val Val Val 
        275                 280                 285             

Ala Val Gly Ser Val Ala Asp Glu Val Val Glu Arg Leu Ala Glu Gly 
    290                 295                 300                 

Ala Arg Arg Met Lys Ile Gly His Gly Phe Glu Glu Gly Val Asp Val 
305                 310                 315                 320 

Thr Pro Leu Ile Arg Lys Glu His Arg Asp Arg Val Arg Ala Tyr Val 
                325                 330                 335     

Asp Glu Ala Ala Met Ser Ala Arg Leu Val Val Asp Gly Arg Pro Ala 
            340                 345                 350         

Ile Asp Glu His Pro Glu Gly Phe Tyr Leu Gly Pro Cys Leu Leu Asp 
        355                 360                 365             

Gly Val Thr Pro Glu Met Arg Val Trp Gln Glu Glu Leu Phe Gly Pro 
    370                 375                 380                 

Val Leu Ser Val Val Arg Ala Arg Asp Leu Asp Glu Ala Ile Ala Ile 
385                 390                 395                 400 

Ala Asn Arg Ser Arg Tyr Ala Asn Gly Ala Ile Leu Tyr Thr Gln Ser 
                405                 410                 415     

Gly Lys Ala Ala Gln Val Phe Arg Asp Arg Ile Asp Ala Gly Met Val 
            420                 425                 430         

Gly Ile Asn Val Asn Val Pro Leu Pro Val Ala Phe Phe Pro Phe Gly 
        435                 440                 445             

Gly His Lys Asp Ser Phe Tyr Gly Val Thr Gly Glu Asn Gly Lys Glu 
    450                 455                 460                 

Leu Val Gln Phe Phe Thr Arg Arg Lys Val Val Ser Thr Arg Trp Phe 
465                 470                 475                 480 

<210>   1524
<211>   480
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1514

<400>   1524
Met Arg Arg Leu Gln Asn Tyr Val Asn Gly Thr Trp Val Glu Val Glu 
                5                   10                  15      

Ser Glu His Ala Val Pro Val Tyr Asn Pro Ala Thr Gly Glu Val Ile 
            20                  25                  30          

Ala Glu Thr Pro Leu Ser Thr His Val Asp Val Ala Arg Ala Val Glu 
        35                  40                  45              

Gly Ala Lys Arg Ala Phe Ala Ser Trp Ser Arg Val Pro Val Val Lys 
    50                  55                  60                  

Arg Ala Arg Val Val Phe Asp Phe Leu Ala Lys Leu Lys Ala Glu Arg 
65                  70                  75                  80  

Asp Ala Ile Ala Lys Met Ile Thr Thr Glu His Gly Lys Ser Tyr Leu 
                85                  90                  95      

Asp Ala Gln Ala Glu Val Asp Arg Gly Ile Glu Gly Ile Glu His Ala 
            100                 105                 110         

Leu Ser Ala Pro Thr Leu Met Met Gly Glu Ser Leu Ala Glu Val Ser 
        115                 120                 125             

Glu Gly Leu Glu Gln Thr Tyr Tyr Arg Tyr Pro Leu Gly Val Val Ala 
    130                 135                 140                 

Ser Ile Thr Pro Phe Asn Phe Pro Ala Met Ile Pro Leu Trp Val Met 
145                 150                 155                 160 

Gly Trp Ala Val Val Thr Gly Asn Ala Leu Ile Leu Lys Pro Ser Glu 
                165                 170                 175     

Gln Thr Pro Met Thr Thr Leu Arg Leu Val Glu Met Phe His Glu Ala 
            180                 185                 190         

Gly Leu Pro Pro Gly Val Leu Gln Ala Val Asn Gly Gly Lys Glu Ala 
        195                 200                 205             

Val Asp Ala Ile Leu Ser His Pro Glu Ile Val Ala Val Asn Phe Thr 
    210                 215                 220                 

Gly Ser Thr Arg Thr Ala Ala Tyr Val Tyr Glu Thr Ala Ala Arg His 
225                 230                 235                 240 

His Lys Arg Val Gln Ala Phe Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Leu Glu Asp Ala Val Leu Glu Pro Thr Ile Asp Gly Ile Leu Arg Ala 
            260                 265                 270         

Ala Phe His Asn Gly Gly Gln Arg Cys Met Ala Thr Ser Val Val Val 
        275                 280                 285             

Ala Val Gly Ser Val Ala Asp Glu Val Val Glu Arg Leu Ala Glu Gly 
    290                 295                 300                 

Ala Arg Arg Met Lys Ile Gly His Gly Phe Glu Glu Gly Val Asp Val 
305                 310                 315                 320 

Thr Pro Leu Ile Arg Lys Glu His Arg Asp Arg Val Arg Ala Tyr Val 
                325                 330                 335     

Asp Glu Ala Ala Met Ser Ala Arg Leu Val Val Asp Gly Arg Pro Ala 
            340                 345                 350         

Ile Asp Glu His Pro Glu Gly Phe Tyr Leu Gly Pro Cys Leu Leu Asp 
        355                 360                 365             

Gly Val Thr Pro Glu Met Arg Val Trp Gln Glu Glu Leu Phe Gly Pro 
    370                 375                 380                 

Val Leu Ser Val Val Arg Ala Arg Asp Leu Asp Glu Ala Ile Ala Ile 
385                 390                 395                 400 

Ala Asn Arg Ser Arg Tyr Ala Asn Gly Ala Ile Leu Tyr Thr Gln Ser 
                405                 410                 415     

Gly Lys Ala Ala Gln Val Phe Arg Asp Lys Ile Asp Ala Gly Met Val 
            420                 425                 430         

Gly Ile Asn Val Asn Val Pro Leu Pro Val Ala Phe Phe Pro Phe Gly 
        435                 440                 445             

Gly His Lys Asp Ser Phe Tyr Gly Val Thr Gly Glu Asn Gly Lys Glu 
    450                 455                 460                 

Leu Val Gln Phe Phe Thr Arg Arg Lys Val Val Ser Thr Arg Trp Phe 
465                 470                 475                 480 

<210>   1525
<211>   480
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1514

<400>   1525
Met Arg Arg Leu Gln Asn Tyr Val Asn Gly Thr Trp Val Glu Val Glu 
                5                   10                  15      

Ser Glu His Ala Val Pro Val Tyr Asn Pro Ala Thr Gly Glu Val Ile 
            20                  25                  30          

Ala Glu Thr Pro Leu Ser Thr His Val Asp Val Ala Arg Ala Val Glu 
        35                  40                  45              

Gly Ala Lys Lys Ala Phe Ala Ser Trp Ser Arg Val Pro Val Val Lys 
    50                  55                  60                  

Arg Ala Arg Val Val Phe Asp Phe Leu Ala Lys Leu Lys Ala Glu Arg 
65                  70                  75                  80  

Asp Ala Ile Ala Lys Met Ile Thr Thr Glu His Gly Lys Ser Tyr Leu 
                85                  90                  95      

Asp Ala Gln Ala Glu Val Asp Arg Gly Ile Glu Gly Ile Glu His Ala 
            100                 105                 110         

Leu Ser Ala Pro Thr Leu Met Met Gly Glu Ser Leu Ala Glu Val Ser 
        115                 120                 125             

Glu Gly Leu Glu Gln Thr Tyr Tyr Arg Tyr Pro Leu Gly Val Val Ala 
    130                 135                 140                 

Ser Ile Thr Pro Phe Asn Phe Pro Ala Met Ile Pro Leu Trp Val Met 
145                 150                 155                 160 

Gly Trp Ala Val Val Thr Gly Asn Ala Leu Ile Leu Lys Pro Ser Glu 
                165                 170                 175     

Gln Thr Pro Met Thr Thr Leu Arg Leu Val Glu Met Phe His Glu Ala 
            180                 185                 190         

Gly Leu Pro Pro Gly Val Leu Gln Ala Val Asn Gly Gly Lys Glu Ala 
        195                 200                 205             

Val Asp Ala Ile Leu Ser His Pro Glu Ile Val Ala Val Asn Phe Thr 
    210                 215                 220                 

Gly Ser Thr Arg Thr Ala Ala Tyr Val Tyr Glu Thr Ala Ala Arg His 
225                 230                 235                 240 

His Lys Arg Val Gln Ala Phe Ala Gly Ala Lys Asn His Ala Ile Val 
                245                 250                 255     

Leu Glu Asp Ala Val Leu Glu Pro Thr Ile Asp Gly Ile Leu Arg Ala 
            260                 265                 270         

Ala Phe His Asn Gly Gly Gln Arg Cys Met Ala Thr Ser Val Val Val 
        275                 280                 285             

Ala Val Gly Ser Val Ala Asp Glu Val Val Glu Arg Leu Ala Glu Gly 
    290                 295                 300                 

Ala Arg Arg Met Lys Ile Gly His Gly Phe Glu Glu Gly Val Asp Val 
305                 310                 315                 320 

Thr Pro Leu Ile Arg Lys Glu His Arg Asp Arg Val Arg Ala Tyr Val 
                325                 330                 335     

Asp Glu Ala Ala Met Ser Ala Arg Leu Val Val Asp Gly Arg Pro Ala 
            340                 345                 350         

Ile Asp Glu His Pro Glu Gly Phe Tyr Leu Gly Pro Cys Leu Leu Asp 
        355                 360                 365             

Gly Val Thr Pro Glu Met Arg Val Trp Gln Glu Glu Leu Phe Gly Pro 
    370                 375                 380                 

Val Leu Ser Val Val Arg Ala Arg Asp Leu Asp Glu Ala Ile Ala Ile 
385                 390                 395                 400 

Ala Asn Arg Ser Arg Tyr Ala Asn Gly Ala Ile Leu Tyr Thr Gln Ser 
                405                 410                 415     

Gly Lys Ala Ala Gln Val Phe Arg Asp Arg Ile Asp Ala Gly Met Val 
            420                 425                 430         

Gly Ile Asn Val Asn Val Pro Leu Pro Val Ala Phe Phe Pro Phe Gly 
        435                 440                 445             

Gly His Lys Asp Ser Phe Tyr Gly Val Thr Gly Glu Asn Gly Lys Glu 
    450                 455                 460                 

Leu Val Gln Phe Phe Thr Arg Arg Lys Val Val Ser Thr Arg Trp Phe 
465                 470                 475                 480 

<210>   1526
<211>   1443
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1515

<400>   1526
atgcgccgtc tccaaaacta tgtgaatgga acttgggtgg aagttgagag cgaacacgcc       60

gtaccggtgt acaatcccgc gactggggaa gtcatcgccg agacgccgct ttcgacgcac      120

gtcgatgtgg cgcgggccgt ggagggcgcg aagcgggcgt ttgcgtcgtg gagccgggtg      180

cccgtcgtga agcgggcccg ggtggtgttc gacttcttgg cgaagctgaa ggcggagcga      240

gacgccatcg ccaagatgat cacgacggag cacggaaaga gctacctgga tgcgcaggcc      300

gaggtggatc gcggcatcga gggcatcgaa cacgcgctgt ccgcgcccac gctgatgatg      360

ggcgaatcgc tcgccgaggt gtcggagggg ctggagcaga cgtactaccg ctatcccttg      420

ggcgtggtcg ccagcatcac gccgttcaac tttccggcca tgatcccctt gtgggtgatg      480

gggtgggcgg tcgtcaccgg caacgcgctg attttgaagc cgtccgagca gacgccgatg      540

accacgcttc gcctggtgga gatgttccac gaagcgggac tgcccccggg cgtgcttcag      600

gcggtcaacg gcggcaagga agccgtggac gccatcctgt cccatcccga gattgtcgcc      660

gtgaacttca cgggttcgac gaggacggcc gcctatgtgt atgagacggc tgcgcgccac      720

cacaagcggg tgcaggcgtt cgcgggtgcg aagaaccacg ccattgtgct ggaggacgcc      780

gtgctcgagc cgaccatcga cggtatcctg cgcgccgcgt tccacaacgg cggccagcgc      840

tgcatggcca cctccgtcgt cgtggccgtc ggctcggtgg cggatgaagt cgtcgagcgg      900

ctggcggagg gcgcgcggcg catgaagatt ggccacggct ttgaggaagg tgtcgacgtc      960

acgccgctca ttcggaagga acatcgcgat cgcgtccgcg cgtacgtcga cgaggccgcc     1020

atgtccgccc ggctcgtggt ggacggacgg ccagccatcg acgaacatcc cgaagggttt     1080

tatctcggcc cgtgcctgct cgatggcgtg acgcccgaga tgaaagtctg gcaggaggag     1140

ttgttcggcc ccgtgctctc cgtggtgcgg gcgcgcgatc tcgacgaggc catcgccatc     1200

gcgaatcgct cccgctacgc gaacggcgcc atcctgtaca cgcagagcgg caaggccgca     1260

caggtgtttc gcgatcgaat cgacgcaggc atggtcggca tcaacgtcaa cgtgcctctg     1320

cctgtggcct tcttcccgtt cggaggacac aaggactcct tctacggcgt gacgggcgag     1380

aacggcaagg agctggttca gtttttcacg cgaaggaagg tcgtctcgac gcgttggttt     1440

tga                                                                   1443


<210>   1527
<211>   1443
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1515

<400>   1527
atgcgccgtc tccaaaacta tgtgaatgga acttgggtgg aagttgagag cgaacacgcc       60

gtaccggtgt acaatcccgc gactggggaa gtcatcgccg agacgccgct ttcgacgcac      120

gtcgatgtgg cgcgggccgt ggagggcgcg aagcgggcgt ttgcgtcgtg gagccgggtg      180

cccgtcgtga agcgggcccg ggtggtgttc gacttcttgg cgaagctgaa ggcggagcga      240

gacgccatcg ccaagatgat cacgacggag cacggaaaga gctacctgga tgcgcaggcc      300

gaggtggatc gcggcatcga gggcatcgaa cacgcgctgt ccgcgcccac gctgatgatg      360

ggcgaatcgc tcgccgaggt gtcggagggg ctggagcaga cgtactaccg ctatcccttg      420

ggcgtggtcg ccagcatcac gccgttcaac tttccggcca tgatcccctt gtgggtgatg      480

gggtgggcgg tcgtcaccgg caacgcgctg attttgaagc cgtccgagca gacgccgatg      540

accacgcttc gcctggtgga gatgttccac gaagcgggac tgcccccggg cgtgcttcag      600

gcggtcaacg gcggcaagga agccgtggac gccatcctgt cccatcccga gattgtcgcc      660

gtgaacttca cgggttcgac gaggacggcc gcctatgtgt atgagacggc tgcgcgccac      720

cacaagcggg tgcaggcgtt cgcgggtgcg aagaaccacg ccattgtgct ggaggacgcc      780

gtgctcgagc cgaccatcga cggtatcctg cgcgccgcgt tccacaacgg cggccagcgc      840

tgcatggcca cctccgtcgt cgtggccgtc ggctcggtgg cggatgaagt cgtcgagcgg      900

ctggcggagg gcgcgcggcg catgaagatt ggccacggct ttgaggaagg tgtcgaagtc      960

acgccgctca ttcggaagga acatcgcgat cgcgtccgcg cgtacgtcga cgaggccgcc     1020

atgtccgccc ggctcgtggt ggacggacgg ccagccatcg acgaacatcc cgaagggttt     1080

tatctcggcc cgtgcctgct cgatggcgtg acgcccgaga tgcgcgtctg gcaggaggag     1140

ttgttcggcc ccgtgctctc cgtggtgcgg gcgcgcgatc tcgacgaggc catcgccatc     1200

gcgaatcgct cccgctacgc gaacggcgcc atcctgtaca cgcagagcgg caaggccgca     1260

caggtgtttc gcgatcgaat cgacgcaggc atggtcggca tcaacgtcaa cgtgcctctg     1320

cctgtggcct tcttcccgtt cggaggacac aaggactcct tctacggcgt gacgggcgag     1380

aacggcaagg agctggttca gtttttcacg cgaaggaagg tcgtctcgac gcgttggttt     1440

tga                                                                   1443


<210>   1528
<211>   1443
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1515

<400>   1528
atgcgccgtc tccaaaacta tgtgaatgga acttgggtgg aagttgagag cgaacacgcc       60

gtaccggtgt acaatcccgc gactggggaa gtcatcgccg agacgccgct ttcgacgcac      120

gtcgatgtgg cgcgggccgt ggagggcgcg aagcgggcgt ttgcgtcgtg gagccgggtg      180

cccgtcgtga agcgggcccg ggtggtgttc gacttcttgg cgaagctgaa ggcggagcga      240

gacgccatcg ccaagatgat cacgacggag cacggaaaga gctacctgga tgcgcaggcc      300

gaggtggatc gcggcatcga gggcatcgaa cacgcgctgt ccgcgcccac gctgatgatg      360

ggcgaatcgc tcgccgaggt gtcggagggg ctggagcaga cgtactaccg ctatcccttg      420

ggcgtggtcg ccagcatcac gccgttcaac tttccggcca tgatcccctt gtgggtgatg      480

gggtgggcgg tcgtcaccgg caacgcgctg attttgaagc cgtccgagca gacgccgatg      540

accacgcttc gcctggtgga gatgttccac gaagcgggac tgcccccggg cgtgcttcag      600

gcggtcaacg gcggcaagga agccgtggac gccatcctgt cccatcccga gattgtcgcc      660

gtgaacttca cgggttcgac gaggacggcc gcctatgtgt atgagacggc tgcgcgccac      720

cacaagcggg tgcaggcgtt cgcgggtgcg aagaaccacg ccattgtgct ggaggacgcc      780

attctcgagc cgaccatcga cggtatcctg cgcgccgcgt tccacaacgg cggccagcgc      840

tgcatggcca cctccgtcgt cgtggccgtc ggctcggtgg cggatgaagt cgtcgagcgg      900

ctggcggagg gcgcgcggcg catgaagatt ggccacggct ttgaggaagg tgtcgacgtc      960

acgccgctca ttcggaagga acatcgcgat cgcgtccgcg cgtacgtcga cgaggccgcc     1020

atgtccgccc ggctcgtggt ggacggacgg ccagccatcg acgaacatcc cgaagggttt     1080

tatctcggcc cgtgcctgct cgatggcgtg acgcccgaga tgcgcgtctg gcaggaggag     1140

ttgttcggcc ccgtgctctc cgtggtgcgg gcgcgcgatc tcgacgaggc catcgccatc     1200

gcgaatcgct cccgctacgc gaacggcgcc atcctgtaca cgcagagcgg caaggccgca     1260

caggtgtttc gcgatcgaat cgacgcaggc atggtcggca tcaacgtcaa cgtgcctctg     1320

cctgtggcct tcttcccgtt cggaggacac aaggactcct tctacggcgt gacgggcgag     1380

aacggcaagg agctggttca gtttttcacg cgaaggaagg tcgtctcgac gcgttggttt     1440

tga                                                                   1443


<210>   1529
<211>   1443
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1515

<400>   1529
atgcgccgtc tccaaaacta tgtgaatgga acttgggtgg aagttgagag cgaacacgcc       60

gtaccggtgt acaatcccgc gactggggaa gtcatcgccg agacgccgct ttcgacgcac      120

gtcgatgtgg cgcgggccgt ggagggcgcg aagcgggcgt ttgcgtcgtg gagccgggtg      180

cccgtcgtga agcgggcccg ggtggtgttc gacttcttgg cgaagctgaa ggcggagcga      240

gacgccatcg ccaagatgat cacgacggag cacggaaaga gctacctgga tgcgcaggcc      300

gaggtggatc gcggcatcga gggcatcgaa cacgcgctgt ccgcgcccac gctgatgatg      360

ggcgaatcgc tcgccgaggt gtcggagggg ctggagcaga cgtactaccg ctatcccttg      420

ggcgtggtcg ccagcatcac gccgttcaac tttccggcca tgatcccctt gtgggtgatg      480

gggtgggcgg tcgtcaccgg caacgcgctg attttgaagc cgtccgagca gacgccgatg      540

accacgcttc gcctggtgga gatgttccac gaagcgggac tgcccccggg cgtgcttcag      600

gcggtcaacg gcggcaagga agccgtggac gccatcctgt cccatcccga gattgtcgcc      660

gtgaacttca cgggttcgac gaggacggcc gcctatgtgt atgagacggc tgcgcgccac      720

cacaagcggg tgcaggcgtt cgcgggtgcg aagaaccacg ccattgtgct ggaggacgcc      780

gtgctcgagc cgaccatcga cggtatcctg cgcgccgcgt tccacaacgg cggccagcgc      840

tgcatggcca cctccgtcgt cgtggccgtc ggctcggtgg cggatgaagt cgtcgagcgg      900

ctggcggagg gcgcgcggcg catgaagatt ggccacggct ttgaggaagg tgtcgacgtc      960

acgccgctca ttcggaagga acatcgcgat cgcgtccgcg cgtacgtcga cgaggccgcc     1020

atgtccgccc ggctcgtggt ggacggacgg ccagccatcg acgaacatcc cgaagggttt     1080

tatctcggcc cgtgcctgct cgatggcgtg acgcccgaga tgcgcgtctg gcaggaggag     1140

ttgttcggcc ccgtgctctc cgtggtgcgg gcgcgcgatc tcgacgaggc catcgccatc     1200

gcgaatcgct cccgctacgc gaacggcgcc atcctgtaca cgcagagcgg caaggccgca     1260

caggtgtttc gcgataaaat cgacgcaggc atggtcggca tcaacgtcaa cgtgcctctg     1320

cctgtggcct tcttcccgtt cggaggacac aaggactcct tctacggcgt gacgggcgag     1380

aacggcaagg agctggttca gtttttcacg cgaaggaagg tcgtctcgac gcgttggttt     1440

tga                                                                   1443


<210>   1530
<211>   1443
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1515

<400>   1530
atgcgccgtc tccaaaacta tgtgaatgga acttgggtgg aagttgagag cgaacacgcc       60

gtaccggtgt acaatcccgc gactggggaa gtcatcgccg agacgccgct ttcgacgcac      120

gtcgatgtgg cgcgggccgt ggagggcgcg aagaaagcgt ttgcgtcgtg gagccgggtg      180

cccgtcgtga agcgggcccg ggtggtgttc gacttcttgg cgaagctgaa ggcggagcga      240

gacgccatcg ccaagatgat cacgacggag cacggaaaga gctacctgga tgcgcaggcc      300

gaggtggatc gcggcatcga gggcatcgaa cacgcgctgt ccgcgcccac gctgatgatg      360

ggcgaatcgc tcgccgaggt gtcggagggg ctggagcaga cgtactaccg ctatcccttg      420

ggcgtggtcg ccagcatcac gccgttcaac tttccggcca tgatcccctt gtgggtgatg      480

gggtgggcgg tcgtcaccgg caacgcgctg attttgaagc cgtccgagca gacgccgatg      540

accacgcttc gcctggtgga gatgttccac gaagcgggac tgcccccggg cgtgcttcag      600

gcggtcaacg gcggcaagga agccgtggac gccatcctgt cccatcccga gattgtcgcc      660

gtgaacttca cgggttcgac gaggacggcc gcctatgtgt atgagacggc tgcgcgccac      720

cacaagcggg tgcaggcgtt cgcgggtgcg aagaaccacg ccattgtgct ggaggacgcc      780

gtgctcgagc cgaccatcga cggtatcctg cgcgccgcgt tccacaacgg cggccagcgc      840

tgcatggcca cctccgtcgt cgtggccgtc ggctcggtgg cggatgaagt cgtcgagcgg      900

ctggcggagg gcgcgcggcg catgaagatt ggccacggct ttgaggaagg tgtcgacgtc      960

acgccgctca ttcggaagga acatcgcgat cgcgtccgcg cgtacgtcga cgaggccgcc     1020

atgtccgccc ggctcgtggt ggacggacgg ccagccatcg acgaacatcc cgaagggttt     1080

tatctcggcc cgtgcctgct cgatggcgtg acgcccgaga tgcgcgtctg gcaggaggag     1140

ttgttcggcc ccgtgctctc cgtggtgcgg gcgcgcgatc tcgacgaggc catcgccatc     1200

gcgaatcgct cccgctacgc gaacggcgcc atcctgtaca cgcagagcgg caaggccgca     1260

caggtgtttc gcgatcgaat cgacgcaggc atggtcggca tcaacgtcaa cgtgcctctg     1320

cctgtggcct tcttcccgtt cggaggacac aaggactcct tctacggcgt gacgggcgag     1380

aacggcaagg agctggttca gtttttcacg cgaaggaagg tcgtctcgac gcgttggttt     1440

tga                                                                   1443


<210>   1531
<211>   548
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1531
Met Glu Pro Ser Gln Thr Ala Ala Phe Ala Glu Leu Leu Ala Pro Asp 
                5                   10                  15      

Val Phe Asn Ile Ala Ser Ala Ile Leu Asp Arg Asp Glu Ser Arg Arg 
            20                  25                  30          

Ala Leu Val Trp Arg Ser Glu Ala Gly Ala Lys Arg Thr Leu Thr Tyr 
        35                  40                  45              

Gly Glu Leu Arg Arg Glu Ser Leu Arg Leu Ala Gln Ser Leu His Asp 
    50                  55                  60                  

Leu Gly Leu Arg Lys Gly Asp Arg Val Leu Val Leu Met Pro Arg Arg 
65                  70                  75                  80  

Pro Glu Thr Tyr Ala Val Tyr Leu Ala Ile Leu Ser Leu Gly Ala Val 
                85                  90                  95      

Val Leu Pro Gly Ser Glu Leu Leu Met Pro Asn Asp Ile Ala Tyr Arg 
            100                 105                 110         

Leu Arg His Ala Glu Ala Lys Gly Val Ile Ala His Ala Ala Leu Ala 
        115                 120                 125             

Glu Arg Ala Glu Ala Ala Ile Ala Glu Ala Pro Trp Val Gln Leu Arg 
    130                 135                 140                 

Val Val Val Glu Gly Pro Arg Glu Gly Trp Leu Ala Tyr Asp Asp Leu 
145                 150                 155                 160 

Val Arg Gly Ala Pro Arg Glu Trp Asp Val Val Pro Thr Arg Arg Asp 
                165                 170                 175     

Asp Leu Ala Phe Leu Ser Tyr Thr Ser Gly Thr Thr Gly Tyr Pro Lys 
            180                 185                 190         

Gly Val Met His Val His Gly Trp Ala Tyr Ala His Trp His Ile Ala 
        195                 200                 205             

Ala Lys Arg Trp Leu Gly Ile Glu Pro Asp Asp Val Val Trp Ala Thr 
    210                 215                 220                 

Ala Gly Pro Gly Trp Ala Lys Trp Ile Trp Ser Pro Phe Val Ala Thr 
225                 230                 235                 240 

Leu Met Ser Gly Ala Thr Gly Phe His Tyr Gly Gly Arg Phe Asp Ala 
                245                 250                 255     

Glu Thr Phe Leu Arg Leu Ile Asp Asp Glu Ala Val Asn Val Leu Cys 
            260                 265                 270         

Ala Thr Pro Thr Glu Tyr Arg Met Met Ala Lys Val Asp Gly Leu Asp 
        275                 280                 285             

Arg Phe Arg Leu Ser Ser Leu Arg Gln Ala Val Ser Ala Gly Glu Pro 
    290                 295                 300                 

Leu Asn Arg Glu Val Ile Asp Thr Phe Arg Arg His Phe Gln Val Thr 
305                 310                 315                 320 

Val Arg Asp Gly Tyr Gly Gln Thr Glu Asn Thr Leu Leu Val Ala Thr 
                325                 330                 335     

Cys Val Asp Thr Glu Val Arg Pro Gly Ser Met Gly Leu Pro Thr Val 
            340                 345                 350         

Glu Gly Ala Val Asp Ile Val Asp Asp Glu Gly Arg Pro Leu Pro Pro 
        355                 360                 365             

Gly Gln Val Gly Asp Ile Ala Val Arg Arg Asp Phe Pro Ala Leu Phe 
    370                 375                 380                 

Arg Gly Tyr Tyr Lys Asp Asp Glu Arg Thr Glu Ala Gln Phe Arg Gly 
385                 390                 395                 400 

Ala Trp Tyr Ile Thr Gly Asp Arg Ala Glu Lys Asp Glu Asp Gly Tyr 
                405                 410                 415     

Leu Trp Phe Ser Gly Arg Ala Asp Asp Ile Ile Ile Ser Ala Gly Tyr 
            420                 425                 430         

Thr Ile Gly Pro Phe Glu Val Glu Asp Ala Leu Val Lys His Pro Leu 
        435                 440                 445             

Val Arg Glu Cys Ala Ala Val Ser Ser Pro Asp Glu Val Arg Gly Ala 
    450                 455                 460                 

Ile Val Lys Ala Phe Val Val Leu Lys Asp Ala Asn Leu His Arg Glu 
465                 470                 475                 480 

Leu Ala Ser Asp Gly Glu Arg Arg Glu Ala Leu Val Arg Glu Leu Gln 
                485                 490                 495     

Glu His Val Lys Arg Ile Thr Ala Pro Tyr Lys Tyr Pro Arg Ala Ile 
            500                 505                 510         

Glu Phe Val Glu Asp Leu Pro Lys Thr Thr Ser Gly Lys Ile Arg Arg 
        515                 520                 525             

Val Glu Leu Arg Glu Arg Glu Trp Lys Arg His Arg Lys Leu Asn Glu 
    530                 535                 540                 

Glu Gln Gly Gly 
545             

<210>   1532
<211>   1647
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1532
atggagccat cccaaaccgc cgcatttgcg gagcttctgg cgccggacgt gttcaacatc       60

gcgagcgcca ttctggaccg ggacgaatcg aggcgcgcgc tcgtgtggcg ctcggaggcc      120

ggggcgaagc ggaccctgac gtacggcgag cttcgccgcg agtcccttcg cctggcgcaa      180

tctcttcacg atctcggcct tcgaaaaggc gaccgggtcc tggtgttgat gccgcgccgc      240

ccggagacct acgccgtgta tctcgccatc ctctcgctcg gcgccgtggt tctgcccgga      300

tcggagttac tcatgccgaa cgacatcgcc tatcgcctga gacacgcgga ggcgaagggc      360

gtgatcgccc acgcggcgct cgcggagcgg gccgaggcgg ccatcgccga ggcgccgtgg      420

gtgcagttgc gcgtcgtggt cgagggcccg cgcgaaggct ggctggcgta tgacgacctc      480

gtgcgcggcg cccccaggga gtgggacgtg gttccgacgc gtcgggacga tctcgccttc      540

ctgtcgtaca cctccgggac gacgggctac cccaagggtg tgatgcatgt ccacggctgg      600

gcgtacgcgc actggcacat cgccgcgaag cgctggctcg gcattgagcc tgacgacgtg      660

gtgtgggcca ccgccgggcc cggatgggcg aagtggatct ggagcccctt cgtcgccacg      720

ctcatgtcgg gcgccacagg cttccactac ggtggccgat ttgacgcgga gacgtttctt      780

cggctcatcg acgacgaagc ggtcaatgtg ctctgcgcga cgcccacgga ataccggatg      840

atggccaagg tggacggcct cgatcggttt cgcctctcgt cgctgcgcca ggcggtgagc      900

gcgggcgagc ctcttaaccg agaagtcatt gacacgttcc gccgccattt tcaggtcacc      960

gtgcgcgacg gctacgggca gacggagaac acgcttctcg ttgcgacgtg cgtcgatacg     1020

gaggtgcgcc ccggttcgat ggggctgccg acggtcgaag gggccgtcga cattgtcgac     1080

gacgagggca ggccacttcc tccgggccag gtgggggaca tcgcggtcag gcgagacttc     1140

ccggccctct tccggggtta ctacaaggac gacgagcgga ccgaggctca gtttcggggc     1200

gcgtggtaca tcacgggcga tcgcgccgag aaagacgagg acggatatct gtggttcagc     1260

ggccgcgcgg acgacatcat catcagcgct ggatacacca tcgggccgtt tgaggtcgag     1320

gacgcgctcg tgaaacatcc gctggtgcgc gagtgcgcag cggtgtcgag cccggatgag     1380

gtgcggggcg caattgtgaa ggcgttcgtc gtcctcaagg atgccaactt gcaccgagag     1440

ctggcatccg acggcgagcg acgcgaggcg ctggtgcgag aactgcagga gcacgtgaag     1500

cggatcaccg cgccctacaa gtatccgcgc gcaattgagt ttgtggagga tttgccgaag     1560

acgacgtcgg ggaagattcg ccgcgtcgag ctcagggagc gcgagtggaa gcggcaccgc     1620

aagctgaacg aggagcaggg agggtga                                         1647


<210>   1533
<211>   518
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1533
Asp Leu Ile Ala Pro Glu Arg Tyr Asn Leu Thr Ser Glu Met Glu Arg 
                5                   10                  15      

His Ala Ala Ala Asp Pro Asp Arg Ile Ala Leu Lys Trp Glu Ser Glu 
            20                  25                  30          

Gln Gly Glu Thr Lys Glu Ile Thr Tyr Gly Arg Leu Met Ala Arg Ala 
        35                  40                  45              

Asn Gln Ile Gly Asn Ala Phe Leu Ser His Gly Leu Glu Lys Gly Asp 
    50                  55                  60                  

Lys Val Leu Val Met Met Pro Arg Leu Ile Glu Thr Tyr Glu Val Tyr 
65                  70                  75                  80  

Ile Gly Ala Leu Lys Ala Gly Leu Val Val Ile Pro Ser Ser Glu Met 
                85                  90                  95      

Leu Arg Thr Lys Asp Leu Gln Tyr Arg Leu Val His Ser Glu Ala Lys 
            100                 105                 110         

Ala Val Val Ala Tyr Ala Pro Tyr Thr Asp Glu Phe Ala Pro Ile Asp 
        115                 120                 125             

Gly Ile Glu Arg Leu Thr Lys Phe Val Ile Gly Glu Pro Arg Asp Gly 
    130                 135                 140                 

Trp Ile Pro Leu Glu Asp Ala Met Ala Lys Glu Ser Glu Thr Leu Glu 
145                 150                 155                 160 

Ala Ala Asp Thr Ser Arg Asp Asp Met Ala Phe Leu Ser Tyr Thr Ser 
                165                 170                 175     

Gly Thr Thr Gly Asn Pro Lys Gly Val Val His Cys His Gly Trp Ala 
            180                 185                 190         

Tyr Ala His Leu Arg Thr Ala Ala Lys Asn Trp Leu Cys Ile Glu Glu 
        195                 200                 205             

Gly Asp Leu Val Trp Ala Thr Ala Gly Pro Gly Trp Gln Lys Trp Ile 
    210                 215                 220                 

Trp Ser Pro Phe Leu Ser Val Leu Gly Ser Gly Ala Thr Gly Phe Val 
225                 230                 235                 240 

Tyr Tyr Gly Arg Phe Glu Pro Glu Thr Tyr Leu Gln Leu Leu Glu Lys 
                245                 250                 255     

Tyr Asn Ile Asn Val Leu Cys Cys Thr Pro Thr Glu Tyr Arg Leu Met 
            260                 265                 270         

Ala Lys Val Pro Asp Ile Gly Arg Tyr His Leu Ser His Leu His Ser 
        275                 280                 285             

Ala Val Ser Ala Gly Glu Pro Leu Asn Arg Glu Val Ile Asp Thr Phe 
    290                 295                 300                 

Ala Lys His Phe Gly Val Glu Val Arg Asp Gly Tyr Gly Gln Thr Glu 
305                 310                 315                 320 

Asn Thr Leu Leu Val Gly Val Met Lys Gly Met Pro Ile Lys Pro Gly 
                325                 330                 335     

Ser Met Gly Lys Pro Thr Pro Gly Asn Arg Val Glu Ile Ile Asp Glu 
            340                 345                 350         

Asn Gly Glu Pro Cys Pro Pro Gly Gln Val Gly Asp Ile Ala Val His 
        355                 360                 365             

Ile Glu Thr Pro Ala Leu Phe Lys Tyr Tyr Tyr Lys Asp Pro Glu Arg 
    370                 375                 380                 

Thr Ala Met Gln Phe Arg Gly Asp Tyr Tyr Ile Thr Gly Asp Lys Ala 
385                 390                 395                 400 

Arg Lys Asp Glu Asp Gly Tyr Phe Trp Phe Glu Gly Arg Gly Asp Asp 
                405                 410                 415     

Ile Ile Ile Ser Ala Gly Tyr Thr Ile Gly Pro Phe Glu Val Glu Asp 
            420                 425                 430         

Ala Leu Val Lys His Pro Ala Val Lys Glu Cys Ala Val Val Ala Ser 
        435                 440                 445             

Pro Asp Glu Val Arg Gly His Val Val Lys Ala Phe Val Val Leu Arg 
    450                 455                 460                 

Asp Gly Val Asp Lys Asp Asp Pro Ser Leu Ile Pro Ala Leu Gln Glu 
465                 470                 475                 480 

His Val Lys Gln Leu Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Ile Glu 
                485                 490                 495     

Phe Val Asp Asp Leu Pro Lys Thr Ala Ser Gly Lys Ile Arg Arg Val 
            500                 505                 510         

Glu Leu Arg Glu Arg Glu 
        515             

<210>   1534
<211>   521
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   1534
Ser Asp Leu Ile Ala Pro Gln Thr Tyr Asn Ile Ala Glu Glu Ile Glu 
                5                   10                  15      

Lys Tyr Ala Arg Asp Pro His Lys Val Ala Leu Ile Trp Glu Asp Lys 
            20                  25                  30          

Glu Gly Met His Arg Glu Val Thr Tyr Lys Glu Leu Ile Glu Asn Ala 
        35                  40                  45              

Asn Arg Thr Gly His Val Phe Leu Glu Ser Gly Leu Lys Lys Gly Asp 
    50                  55                  60                  

Thr Ile Leu Val Met Val Pro Arg Ile Val Glu Ala Tyr Glu Val Tyr 
65                  70                  75                  80  

Leu Ala Ala Met Lys Cys Gly Ile Val Leu Leu Pro Ala Ser Glu Met 
                85                  90                  95      

Leu Arg Thr Lys Asp Leu Asp Tyr Arg Ile Glu Ala Gly Asp Val Lys 
            100                 105                 110         

Gly Val Val Ala His Tyr Ser Cys Thr Glu Gln Phe Lys Glu Val Arg 
        115                 120                 125             

Gly Ile Asp His Leu Lys Lys Phe Val Ile Gly Glu Pro Glu Gln Gly 
    130                 135                 140                 

Trp Ala Phe Leu Asp Glu Lys Lys Lys Ala Ala Pro Cys Glu Leu Glu 
145                 150                 155                 160 

Ile Ala Lys Thr Ser Lys Asp Asp Ile Ala Ile Leu Ser Tyr Thr Ser 
                165                 170                 175     

Gly Thr Thr Gly Asn Pro Lys Gly Val Ile His Thr His Ser Trp Gly 
            180                 185                 190         

Tyr Ala His Leu Arg Thr Ala Ala Pro Asn Trp Leu Gly Ile Gln Lys 
        195                 200                 205             

Gly Asp Arg Val Trp Ala Thr Ala Ala Pro Gly Trp Gln Lys Trp Val 
    210                 215                 220                 

Trp Ser Pro Phe Leu Ser Val Leu Gly Ser Gly Ala Ile Gly Phe Val 
225                 230                 235                 240 

Tyr Asn Gly Arg Phe Asp Pro Glu Lys Tyr Leu Ser Leu Leu Asp Glu 
                245                 250                 255     

Tyr Glu Ile Asn Val Leu Cys Cys Thr Pro Thr Glu Tyr Arg Leu Met 
            260                 265                 270         

Ala Lys Val Asp Asp Leu Ser Gln Tyr His Leu Lys Ser Leu Arg Ser 
        275                 280                 285             

Ala Val Ser Ala Gly Glu Pro Leu Asn Arg Glu Val Ile Asp Val Phe 
    290                 295                 300                 

Gln Asn His Phe Gly Ile Thr Ile Arg Asp Gly Tyr Gly Gln Thr Glu 
305                 310                 315                 320 

Ser Thr Leu Leu Val Gly Tyr Ser Leu Asp Thr Pro Leu Arg Pro Gly 
                325                 330                 335     

Ser Met Gly Lys Pro Phe Pro Gly Asn Glu Val Glu Ile Val Asn Asp 
            340                 345                 350         

Asp Gly Lys Pro Cys Lys Leu Gly Glu Thr Gly Asp Ile Ala Val His 
        355                 360                 365             

Arg Asp Thr Pro Ala Leu Phe Lys Gly Tyr Tyr Lys Glu Pro Glu Arg 
    370                 375                 380                 

Thr Ala Lys Gln Tyr Arg Gly Asp Tyr Phe Ile Thr Gly Asp Arg Ala 
385                 390                 395                 400 

Arg Lys Asp Glu Asp Gly Tyr Phe Trp Phe Glu Gly Arg Arg Asp Asp 
                405                 410                 415     

Ile Ile Ile Ser Ser Gly Tyr Thr Ile Gly Pro Phe Glu Val Glu Asp 
            420                 425                 430         

Ala Leu Val Lys His Pro Tyr Val Lys Glu Cys Ala Val Val Ala Ser 
        435                 440                 445             

Pro His Glu Ile Arg Gly Ser Ile Val Lys Ala Phe Val Val Leu Lys 
    450                 455                 460                 

Asp Gly Ile Ser Glu Asn Leu Pro Gly Leu Val Lys Glu Leu Gln Asn 
465                 470                 475                 480 

His Val Lys Gln Leu Thr Ala Pro Tyr Lys Tyr Pro Arg Ala Ile Glu 
                485                 490                 495     

Phe Ile Lys Glu Leu Pro Lys Thr Ala Ser Gly Lys Ile Arg Arg Val 
            500                 505                 510         

Glu Leu Arg Gln Gln Glu Trp Asn Arg 
        515                 520     

<210>   1535
<211>   523
<212>   PRT
<213>   Bacillus sp. SG-1

<400>   1535
Asp Leu Leu Ser Pro Glu Arg Tyr Asn Leu Ile Ser Glu Val Glu Lys 
                5                   10                  15      

Phe Ala Gly Glu Gln Gly Lys Lys Ala Ile Ile Trp Lys Ser Glu Gln 
            20                  25                  30          

Gly Glu Glu Lys Glu Ile Thr Tyr Glu Asn Leu Ile Lys Asn Ala Asn 
        35                  40                  45              

Lys Ile Gly Asn Ala Phe Ile Asn Asn Gly Leu Glu Lys Gly Asp Val 
    50                  55                  60                  

Val Leu Val Met Ile Pro Arg Leu Ile Glu Ala Tyr Glu Thr Tyr Val 
65                  70                  75                  80  

Ala Ala Leu Lys Ala Gly Met Val Val Ile Pro Ser Ser Glu Met Leu 
                85                  90                  95      

Arg Ala Lys Asp Leu Lys Tyr Arg Ile Glu His Gly Asp Val Lys Ala 
            100                 105                 110         

Val Val Cys Tyr Glu Pro Tyr Thr Glu Gln Phe Asp Glu Leu Glu Glu 
        115                 120                 125             

Ser Ser Gly Leu Met Lys Phe Val Val Gly Ala Glu Lys Glu Gly Trp 
    130                 135                 140                 

Leu Ser Leu Asp Ser Leu Lys Asn Glu Ser Ser Asp Glu Leu Ala Leu 
145                 150                 155                 160 

Ala Asp Thr Gly Arg Glu Asp Met Ala Phe Leu Ser Tyr Thr Ser Gly 
                165                 170                 175     

Thr Thr Gly Asn Pro Lys Gly Val Val His Thr His Gly Trp Ala Tyr 
            180                 185                 190         

Ala His Leu Arg Thr Ala Ala Lys Lys Trp Leu Ser Ile Glu Glu Gly 
        195                 200                 205             

Asp Thr Val Trp Ala Thr Ala Gly Pro Gly Trp Gln Lys Trp Ile Trp 
    210                 215                 220                 

Ser Pro Phe Leu Ser Val Leu Gly Ser Gly Ala Thr Gly Leu Val Tyr 
225                 230                 235                 240 

Gln Gly Lys Phe Glu Pro Asp Thr Tyr Leu Gln Met Leu Glu Asp Tyr 
                245                 250                 255     

Gln Val Asn Val Leu Cys Cys Thr Pro Thr Glu Tyr Arg Leu Met Ala 
            260                 265                 270         

Lys Val Asp Asp Leu Gly Lys Tyr His Leu Gln His Leu His Ser Ala 
        275                 280                 285             

Val Ser Ala Gly Glu Pro Leu Asn Arg Glu Val Ile Asp Ala Phe Gln 
    290                 295                 300                 

Lys His Phe Asn Val Asp Val Arg Asp Gly Tyr Gly Gln Thr Glu Asn 
305                 310                 315                 320 

Thr Leu Leu Val Gly Ile Met Lys Gly Met Glu Leu Lys Pro Gly Ser 
                325                 330                 335     

Met Gly Lys Pro Thr Pro Gly Asn Arg Val Glu Ile Ile Asp Glu Asp 
            340                 345                 350         

Gly Lys Pro Cys Ser Pro Gly Glu Val Gly Asp Ile Ala Val His Val 
        355                 360                 365             

Asp Thr Pro Ala Leu Phe Lys Asn Tyr Tyr Lys Asp Pro Glu Arg Thr 
    370                 375                 380                 

Ala Met Gln Phe Arg Gly Asp Tyr Tyr Ile Thr Gly Asp Lys Ala Lys 
385                 390                 395                 400 

Lys Asp Glu Asp Gly Tyr Phe Trp Phe Glu Gly Arg Gly Asp Asp Ile 
                405                 410                 415     

Ile Ile Ser Ser Gly Tyr Thr Ile Gly Pro Phe Glu Val Glu Asp Ala 
            420                 425                 430         

Leu Val Lys His Pro Ser Val Lys Glu Cys Ala Val Val Ala Ser Pro 
        435                 440                 445             

Asp Glu Val Arg Gly Asn Ile Val Lys Ala Phe Val Val Leu Arg Asp 
    450                 455                 460                 

Gly Val Ser Pro Glu Asp Pro Asp Leu Val Lys Ser Leu Gln Asp His 
465                 470                 475                 480 

Val Lys Glu Leu Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Ile Glu Phe 
                485                 490                 495     

Ile Glu Glu Leu Pro Lys Thr Thr Ser Gly Lys Ile Arg Arg Ile Glu 
            500                 505                 510         

Leu Arg Gln Asn Glu Arg Lys Thr Val Gln Lys 
        515                 520             

<210>   1536
<211>   524
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   1536
Glu Leu Leu Ala Pro Pro Ser Tyr Asn Leu Val Thr Glu Ile Glu Lys 
                5                   10                  15      

Tyr Met Asn Glu Lys Asp Lys Leu Ala Leu Ile Trp Gln Asp Glu Lys 
            20                  25                  30          

Gly Ala Arg Arg Glu Val Thr Tyr Phe Glu Leu Ile Lys Gly Ala Asn 
        35                  40                  45              

Lys Ile Gly Asn Ala Phe Ile Lys Ser Gly Leu Gln Lys Gly Asp Lys 
    50                  55                  60                  

Leu Leu Ile Met Met Pro Arg Leu Ile Glu Ala Tyr Met Thr Tyr Ile 
65                  70                  75                  80  

Gly Ala Ile Lys Ala Gly Phe Val Val Ile Pro Ser Ser Glu Met Leu 
                85                  90                  95      

Arg Lys Lys Asp Ile Glu Tyr Arg Ile Gln His Gly Glu Val Lys Ala 
            100                 105                 110         

Ile Ile Ser Tyr Glu Pro Tyr Ile Ser Gln Phe Glu Gly Ile Glu Gly 
        115                 120                 125             

Met Asp Ser Leu Gln Lys Phe Val Leu Ser Glu Lys Glu Val Asp Gly 
    130                 135                 140                 

Trp Ala Asn Leu Asn Thr Ala Leu Glu Thr Glu Ser Asp Val Leu Asp 
145                 150                 155                 160 

Ile Val Lys Thr Asp Lys Glu Asp Met Val Phe Leu Ser Tyr Thr Ser 
                165                 170                 175     

Gly Thr Thr Gly Asn Pro Lys Gly Val Val His Thr His Ala Trp Gly 
            180                 185                 190         

Tyr Ala His Leu Arg Thr Ser Ala Pro Asn Trp Leu Gly Ile Glu Glu 
        195                 200                 205             

Asn Asp Ile Val Trp Ala Thr Ala Ser Pro Gly Trp Gln Lys Trp Ile 
    210                 215                 220                 

Trp Ser Pro Phe Leu Ala Thr Leu Gly Ser Gly Ala Thr Gly Phe Val 
225                 230                 235                 240 

Tyr His Gly Lys Phe Glu Pro Lys Thr Tyr Leu Gln Leu Leu Asp Glu 
                245                 250                 255     

Asn Gln Val Asn Val Leu Cys Cys Thr Pro Thr Glu Tyr Arg Leu Met 
            260                 265                 270         

Ala Lys Val Glu Asn Leu Gln Gln Tyr Asn Leu Lys Ala Leu His Ser 
        275                 280                 285             

Ala Val Ser Ala Gly Glu Pro Leu Asn Arg Glu Val Ile Glu Thr Phe 
    290                 295                 300                 

Gln Lys His Phe Gln Val Thr Val Arg Asp Gly Tyr Gly Gln Thr Glu 
305                 310                 315                 320 

Asn Thr Leu Leu Ile Gly Val Met Lys Gly Met Glu Ile Arg Pro Gly 
                325                 330                 335     

Ser Met Gly Lys Pro Thr Pro Gly Asn Gln Val Glu Ile Ile Asn Glu 
            340                 345                 350         

Glu Gly His Pro Val Ser Val Gly Glu Val Gly Asp Ile Ala Val His 
        355                 360                 365             

Ile Asp Thr Pro Ala Leu Phe Lys Gln Tyr Tyr Lys Asp Asp Glu Arg 
    370                 375                 380                 

Thr Ala Met Gln Phe Arg Gly Asp Tyr Tyr Ile Thr Gly Asp Lys Ala 
385                 390                 395                 400 

Lys Lys Asp Glu Asp Gly Tyr Phe Trp Phe Glu Gly Arg Gly Asp Asp 
                405                 410                 415     

Ile Ile Ile Ser Ser Gly Tyr Thr Ile Gly Pro Phe Glu Val Glu Asp 
            420                 425                 430         

Ala Leu Val Lys His Pro Tyr Val Arg Glu Cys Ala Val Val Ala Ser 
        435                 440                 445             

Pro Asp Glu Ile Arg Gly Ser Val Val Lys Ala Phe Ile Val Leu Arg 
    450                 455                 460                 

Asp Asn Val Gln Glu Lys Glu Asp Thr Leu Ile Pro Leu Leu Gln Glu 
465                 470                 475                 480 

His Val Lys Thr Leu Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Ile Glu 
                485                 490                 495     

Phe Val Asp Glu Leu Pro Lys Thr Ile Ser Gly Lys Ile Arg Arg Val 
            500                 505                 510         

Glu Leu Arg Lys Gln Glu Met Glu Leu Arg Leu Lys 
        515                 520                 

<210>   1537
<211>   518
<212>   PRT
<213>   Bacillus thuringiensis serovar konkukian str. 97-27

<400>   1537
Glu Leu Leu Ala Pro Pro Ser Tyr Asn Leu Val Ser Glu Ile Glu Lys 
                5                   10                  15      

Tyr Thr Gly Asp Lys Glu Lys Leu Ala Leu Ile Trp Gln Asp Asp Lys 
            20                  25                  30          

Gly Asn Arg Arg Glu Val Thr Tyr Ala Glu Leu Met Lys Gly Ala Asn 
        35                  40                  45              

Lys Ile Gly Asn Ala Phe Ile Lys Ser Gly Leu Gln Lys Gly Asp Lys 
    50                  55                  60                  

Leu Leu Ile Met Met Pro Arg Leu Ile Glu Ala Tyr Met Thr Tyr Ile 
65                  70                  75                  80  

Ala Ala Ile Lys Ala Gly Phe Val Val Ile Pro Ser Ser Glu Met Leu 
                85                  90                  95      

Arg Lys Lys Asp Ile Glu Tyr Arg Ile Gly His Gly Glu Val Lys Ala 
            100                 105                 110         

Ile Val Ser Tyr Glu Pro Tyr Ile Gly Gln Phe Asp Asp Ile Glu Ala 
        115                 120                 125             

Met Glu Ser Leu Gln Lys Phe Val Leu Ser Glu Gln Ser Val Asp Gly 
    130                 135                 140                 

Trp Ile Asn Leu Lys Thr Ala Leu Glu Thr Glu Ser Asp Met Leu Glu 
145                 150                 155                 160 

Met Ala Lys Thr Asp Lys Glu Asp Met Val Phe Leu Ser Tyr Thr Ser 
                165                 170                 175     

Gly Thr Thr Gly Asn Pro Lys Gly Val Val His Thr His Ala Trp Ala 
            180                 185                 190         

Tyr Ala His Leu Arg Thr Ser Ala Pro Asn Trp Leu Gly Ile Glu Glu 
        195                 200                 205             

Asn Asp Val Val Trp Ala Thr Ala Ser Pro Gly Trp Gln Lys Trp Ile 
    210                 215                 220                 

Trp Ser Pro Phe Leu Ala Thr Leu Gly Ser Gly Ala Thr Gly Phe Val 
225                 230                 235                 240 

Tyr His Gly Lys Phe Glu Pro Lys Thr Tyr Leu Asn Leu Leu Asp Asp 
                245                 250                 255     

Asn Lys Val Asn Val Leu Cys Cys Thr Pro Thr Glu Tyr Arg Leu Met 
            260                 265                 270         

Ala Lys Val Glu Asn Leu Ser Glu Tyr Asn Leu Glu Ala Leu His Ser 
        275                 280                 285             

Ala Val Ser Ala Gly Glu Pro Leu Asn Arg Glu Val Ile Glu Thr Phe 
    290                 295                 300                 

Gln Lys His Phe His Ile Thr Val Arg Asp Gly Tyr Gly Gln Thr Glu 
305                 310                 315                 320 

Asn Thr Leu Leu Val Gly Val Met Lys Gly Met Asp Ile Arg Pro Gly 
                325                 330                 335     

Ser Met Gly Lys Pro Thr Pro Gly Asn His Val Asp Ile Val Asp Glu 
            340                 345                 350         

Glu Gly Met Pro Val Arg Val Gly Glu Val Gly Asp Ile Ala Val His 
        355                 360                 365             

Ile Glu Thr Pro Ala Leu Phe Lys Gln Tyr Tyr Lys Asp Asp Glu Arg 
    370                 375                 380                 

Thr Ala Met Gln Phe Arg Gly Asp Tyr Tyr Ile Thr Gly Asp Lys Ala 
385                 390                 395                 400 

Lys Lys Asp Glu Asp Gly Tyr Phe Trp Phe Glu Gly Arg Gly Asp Asp 
                405                 410                 415     

Ile Ile Ile Ser Ser Gly Tyr Thr Ile Gly Pro Phe Glu Val Glu Asp 
            420                 425                 430         

Ala Leu Val Lys His Pro Tyr Val Arg Glu Cys Ala Val Val Ala Ser 
        435                 440                 445             

Pro Asp Glu Ile Arg Gly Ser Val Val Lys Ala Phe Ile Val Leu Arg 
    450                 455                 460                 

Glu Asn Ile Glu Lys Asn Glu Glu Thr Leu Ile Pro Ile Leu Gln Gln 
465                 470                 475                 480 

His Val Lys Glu Leu Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Ile Glu 
                485                 490                 495     

Phe Val Asp Glu Leu Pro Lys Thr Ile Ser Gly Lys Ile Arg Arg Ile 
            500                 505                 510         

Glu Leu Arg Lys Gln Glu 
        515             

<210>   1538
<211>   548
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1531

<400>   1538
Met Glu Pro Ser Gln Thr Ala Ala Phe Ala Glu Leu Leu Ala Pro Asp 
                5                   10                  15      

Val Phe Asn Ile Ala Ser Ala Ile Leu Asp Arg Asp Glu Ser Arg Arg 
            20                  25                  30          

Ala Leu Val Trp Arg Ser Glu Ala Gly Ala Lys Arg Thr Leu Thr Tyr 
        35                  40                  45              

Gly Glu Leu Arg Arg Glu Ser Leu Arg Leu Ala Gln Ser Leu His Asp 
    50                  55                  60                  

Leu Gly Leu Arg Lys Gly Asp Arg Val Leu Val Leu Met Pro Arg Arg 
65                  70                  75                  80  

Pro Glu Thr Tyr Ala Val Tyr Leu Ala Ile Leu Ser Leu Gly Ala Val 
                85                  90                  95      

Val Leu Pro Gly Ser Glu Leu Leu Met Pro Asn Asp Ile Ala Tyr Arg 
            100                 105                 110         

Leu Arg His Ala Glu Ala Lys Gly Val Ile Ala His Ala Ala Leu Ala 
        115                 120                 125             

Glu Arg Ala Glu Ala Ala Ile Ala Glu Ala Pro Trp Val Gln Leu Arg 
    130                 135                 140                 

Val Val Val Glu Gly Pro Arg Glu Gly Trp Leu Ala Tyr Asp Asp Leu 
145                 150                 155                 160 

Val Arg Gly Ala Pro Arg Glu Trp Asp Val Val Pro Thr Arg Arg Asp 
                165                 170                 175     

Asp Leu Ala Phe Leu Ser Tyr Thr Ser Gly Thr Thr Gly Tyr Pro Lys 
            180                 185                 190         

Gly Val Met His Val His Gly Trp Ala Tyr Ala His Trp His Ile Ala 
        195                 200                 205             

Ala Lys Arg Trp Leu Gly Ile Glu Pro Asp Asp Val Val Trp Ala Thr 
    210                 215                 220                 

Ala Gly Pro Gly Trp Ala Lys Trp Ile Trp Ser Pro Phe Val Ala Thr 
225                 230                 235                 240 

Leu Met Ser Gly Ala Thr Gly Phe His Tyr Gly Gly Arg Phe Asp Ala 
                245                 250                 255     

Glu Thr Phe Leu Arg Leu Ile Asp Asp Glu Ala Val Asn Val Leu Cys 
            260                 265                 270         

Ala Thr Pro Thr Glu Tyr Arg Met Met Ala Lys Val Asp Gly Leu Glu 
        275                 280                 285             

Arg Phe Arg Leu Ser Ser Leu Arg Gln Ala Val Ser Ala Gly Glu Pro 
    290                 295                 300                 

Leu Asn Arg Glu Val Ile Asp Thr Phe Arg Arg His Phe Gln Val Thr 
305                 310                 315                 320 

Val Arg Asp Gly Tyr Gly Gln Thr Glu Asn Thr Leu Leu Val Ala Thr 
                325                 330                 335     

Cys Val Asp Thr Glu Val Arg Pro Gly Ser Met Gly Leu Pro Thr Val 
            340                 345                 350         

Glu Gly Ala Val Asp Ile Val Asp Asp Glu Gly Arg Pro Leu Pro Pro 
        355                 360                 365             

Gly Gln Val Gly Asp Ile Ala Val Arg Arg Asp Phe Pro Ala Leu Phe 
    370                 375                 380                 

Arg Gly Tyr Tyr Lys Asp Asp Glu Arg Thr Glu Ala Gln Phe Arg Gly 
385                 390                 395                 400 

Ala Trp Tyr Ile Thr Gly Asp Arg Ala Glu Lys Asp Glu Asp Gly Tyr 
                405                 410                 415     

Leu Trp Phe Ser Gly Arg Ala Asp Asp Ile Ile Ile Ser Ala Gly Tyr 
            420                 425                 430         

Thr Ile Gly Pro Phe Glu Val Glu Asp Ala Leu Val Lys His Pro Leu 
        435                 440                 445             

Val Arg Glu Cys Ala Ala Val Ser Ser Pro Asp Glu Val Arg Gly Ala 
    450                 455                 460                 

Ile Val Lys Ala Phe Val Val Leu Lys Asp Ala Asn Leu His Arg Glu 
465                 470                 475                 480 

Leu Ala Ser Asp Gly Glu Arg Arg Glu Ala Leu Val Arg Glu Leu Gln 
                485                 490                 495     

Glu His Val Lys Arg Ile Thr Ala Pro Tyr Lys Tyr Pro Arg Ala Ile 
            500                 505                 510         

Glu Phe Val Glu Asp Leu Pro Lys Thr Thr Ser Gly Lys Ile Arg Arg 
        515                 520                 525             

Val Glu Leu Arg Glu Arg Glu Trp Lys Arg His Arg Lys Leu Asn Glu 
    530                 535                 540                 

Glu Gln Gly Gly 
545             

<210>   1539
<211>   548
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1531

<400>   1539
Met Glu Pro Ser Gln Thr Ala Ala Phe Ala Glu Leu Leu Ala Pro Asp 
                5                   10                  15      

Val Phe Asn Ile Ala Ser Ala Ile Leu Asp Lys Asp Glu Ser Arg Arg 
            20                  25                  30          

Ala Leu Val Trp Arg Ser Glu Ala Gly Ala Lys Arg Thr Leu Thr Tyr 
        35                  40                  45              

Gly Glu Leu Arg Arg Glu Ser Leu Arg Leu Ala Gln Ser Leu His Asp 
    50                  55                  60                  

Leu Gly Leu Arg Lys Gly Asp Arg Val Leu Val Leu Met Pro Arg Arg 
65                  70                  75                  80  

Pro Glu Thr Tyr Ala Val Tyr Leu Ala Ile Leu Ser Leu Gly Ala Val 
                85                  90                  95      

Val Leu Pro Gly Ser Glu Leu Leu Met Pro Asn Asp Ile Ala Tyr Arg 
            100                 105                 110         

Leu Arg His Ala Glu Ala Lys Gly Val Ile Ala His Ala Ala Leu Ala 
        115                 120                 125             

Glu Arg Ala Glu Ala Ala Ile Ala Glu Ala Pro Trp Val Gln Leu Arg 
    130                 135                 140                 

Val Val Val Glu Gly Pro Arg Glu Gly Trp Leu Ala Tyr Asp Asp Leu 
145                 150                 155                 160 

Val Arg Gly Ala Pro Arg Glu Trp Asp Val Val Pro Thr Arg Arg Asp 
                165                 170                 175     

Asp Leu Ala Phe Leu Ser Tyr Thr Ser Gly Thr Thr Gly Tyr Pro Lys 
            180                 185                 190         

Gly Val Met His Val His Gly Trp Ala Tyr Ala His Trp His Ile Ala 
        195                 200                 205             

Ala Lys Arg Trp Leu Gly Ile Glu Pro Asp Asp Val Val Trp Ala Thr 
    210                 215                 220                 

Ala Gly Pro Gly Trp Ala Lys Trp Ile Trp Ser Pro Phe Val Ala Thr 
225                 230                 235                 240 

Leu Met Ser Gly Ala Thr Gly Phe His Tyr Gly Gly Arg Phe Asp Ala 
                245                 250                 255     

Glu Thr Phe Leu Arg Leu Ile Asp Asp Glu Ala Val Asn Val Leu Cys 
            260                 265                 270         

Ala Thr Pro Thr Glu Tyr Arg Met Met Ala Lys Val Asp Gly Leu Asp 
        275                 280                 285             

Arg Phe Arg Leu Ser Ser Leu Arg Gln Ala Val Ser Ala Gly Glu Pro 
    290                 295                 300                 

Leu Asn Arg Glu Val Ile Asp Thr Phe Arg Arg His Phe Gln Val Thr 
305                 310                 315                 320 

Val Arg Asp Gly Tyr Gly Gln Thr Glu Asn Thr Leu Leu Val Ala Thr 
                325                 330                 335     

Cys Val Asp Thr Glu Val Arg Pro Gly Ser Met Gly Leu Pro Thr Val 
            340                 345                 350         

Glu Gly Ala Val Asp Ile Val Asp Asp Glu Gly Arg Pro Leu Pro Pro 
        355                 360                 365             

Gly Gln Val Gly Asp Ile Ala Val Arg Arg Asp Phe Pro Ala Leu Phe 
    370                 375                 380                 

Arg Gly Tyr Tyr Lys Asp Asp Glu Arg Thr Glu Ala Gln Phe Arg Gly 
385                 390                 395                 400 

Ala Trp Tyr Ile Thr Gly Asp Arg Ala Glu Lys Asp Glu Asp Gly Tyr 
                405                 410                 415     

Leu Trp Phe Ser Gly Arg Ala Asp Asp Ile Ile Ile Ser Ala Gly Tyr 
            420                 425                 430         

Thr Ile Gly Pro Phe Glu Val Glu Asp Ala Leu Val Lys His Pro Leu 
        435                 440                 445             

Val Arg Glu Cys Ala Ala Val Ser Ser Pro Asp Glu Val Arg Gly Ala 
    450                 455                 460                 

Ile Val Lys Ala Phe Val Val Leu Lys Asp Ala Asn Leu His Arg Glu 
465                 470                 475                 480 

Leu Ala Ser Asp Gly Glu Arg Arg Glu Ala Leu Val Arg Glu Leu Gln 
                485                 490                 495     

Glu His Val Lys Arg Ile Thr Ala Pro Tyr Lys Tyr Pro Arg Ala Ile 
            500                 505                 510         

Glu Phe Val Glu Asp Leu Pro Lys Thr Thr Ser Gly Lys Ile Arg Arg 
        515                 520                 525             

Val Glu Leu Arg Glu Arg Glu Trp Lys Arg His Arg Lys Leu Asn Glu 
    530                 535                 540                 

Glu Gln Gly Gly 
545             

<210>   1540
<211>   548
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1531

<400>   1540
Met Glu Pro Ser Gln Thr Ala Ala Phe Ala Glu Leu Leu Ala Pro Asp 
                5                   10                  15      

Val Phe Asn Ile Ala Ser Ala Ile Leu Asp Arg Asp Glu Ser Arg Arg 
            20                  25                  30          

Ala Leu Val Trp Arg Ser Glu Ala Gly Ala Lys Arg Thr Leu Thr Tyr 
        35                  40                  45              

Gly Glu Leu Arg Arg Glu Ser Leu Arg Leu Ala Gln Ser Leu His Asp 
    50                  55                  60                  

Leu Gly Leu Arg Lys Gly Asp Arg Val Leu Val Leu Met Pro Arg Arg 
65                  70                  75                  80  

Pro Glu Thr Tyr Ala Val Tyr Leu Ala Ile Leu Ser Leu Gly Ala Val 
                85                  90                  95      

Val Leu Pro Gly Ser Glu Leu Leu Met Pro Asn Asp Ile Ala Tyr Arg 
            100                 105                 110         

Leu Arg His Ala Glu Ala Lys Gly Val Ile Ala His Ala Ala Leu Ala 
        115                 120                 125             

Glu Arg Ala Glu Ala Ala Ile Ala Glu Ala Pro Trp Val Gln Leu Arg 
    130                 135                 140                 

Val Val Val Glu Gly Pro Arg Glu Gly Trp Leu Ala Tyr Asp Asp Leu 
145                 150                 155                 160 

Val Arg Gly Ala Pro Arg Glu Trp Asp Val Val Pro Thr Arg Arg Asp 
                165                 170                 175     

Asp Leu Ala Phe Leu Ser Tyr Thr Ser Gly Thr Thr Gly Tyr Pro Lys 
            180                 185                 190         

Gly Val Met His Val His Gly Trp Ala Tyr Ala His Trp His Ile Ala 
        195                 200                 205             

Ala Lys Arg Trp Leu Gly Ile Glu Pro Asp Asp Val Val Trp Ala Thr 
    210                 215                 220                 

Ala Gly Pro Gly Trp Ala Lys Trp Ile Trp Ser Pro Phe Val Ala Thr 
225                 230                 235                 240 

Leu Met Ser Gly Ala Thr Gly Phe His Tyr Gly Gly Arg Phe Asp Ala 
                245                 250                 255     

Glu Thr Phe Leu Arg Leu Ile Asp Asp Glu Ala Val Asn Val Leu Cys 
            260                 265                 270         

Ala Thr Pro Thr Glu Tyr Arg Met Met Ala Lys Val Asp Gly Leu Asp 
        275                 280                 285             

Arg Phe Arg Leu Ser Ser Leu Arg Gln Ala Val Ser Ala Gly Glu Pro 
    290                 295                 300                 

Leu Asn Arg Glu Val Ile Asp Thr Phe Arg Arg His Phe Gln Val Thr 
305                 310                 315                 320 

Val Arg Asp Gly Tyr Gly Gln Thr Glu Asn Thr Leu Leu Val Ala Thr 
                325                 330                 335     

Cys Val Asp Thr Glu Val Arg Pro Gly Ser Met Gly Leu Pro Thr Val 
            340                 345                 350         

Glu Gly Ala Val Asp Ile Val Asp Asp Glu Gly Arg Pro Leu Pro Pro 
        355                 360                 365             

Gly Gln Val Gly Asp Ile Ala Val Arg Arg Asp Phe Pro Ala Leu Phe 
    370                 375                 380                 

Arg Gly Tyr Tyr Lys Asp Asp Glu Arg Thr Glu Ala Gln Phe Arg Gly 
385                 390                 395                 400 

Ala Trp Tyr Ile Thr Gly Asp Arg Ala Glu Lys Asp Glu Asp Gly Tyr 
                405                 410                 415     

Leu Trp Phe Ser Gly Arg Ala Asp Asp Ile Ile Ile Ser Ala Gly Tyr 
            420                 425                 430         

Thr Ile Gly Pro Phe Glu Val Glu Asp Ala Leu Val Lys His Pro Leu 
        435                 440                 445             

Val Arg Glu Cys Ala Ala Val Ser Ser Pro Asp Glu Val Arg Gly Ala 
    450                 455                 460                 

Ile Val Lys Ala Phe Val Val Leu Lys Asp Ala Asn Leu His Lys Glu 
465                 470                 475                 480 

Leu Ala Ser Asp Gly Glu Arg Arg Glu Ala Leu Val Arg Glu Leu Gln 
                485                 490                 495     

Glu His Val Lys Arg Ile Thr Ala Pro Tyr Lys Tyr Pro Arg Ala Ile 
            500                 505                 510         

Glu Phe Val Glu Asp Leu Pro Lys Thr Thr Ser Gly Lys Ile Arg Arg 
        515                 520                 525             

Val Glu Leu Arg Glu Arg Glu Trp Lys Arg His Arg Lys Leu Asn Glu 
    530                 535                 540                 

Glu Gln Gly Gly 
545             

<210>   1541
<211>   548
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1531

<400>   1541
Met Glu Pro Ser Gln Thr Ala Ala Phe Ala Glu Leu Leu Ala Pro Asp 
                5                   10                  15      

Val Phe Asn Ile Ala Ser Ala Ile Leu Asp Arg Asp Glu Ser Arg Arg 
            20                  25                  30          

Ala Leu Val Trp Arg Ser Glu Ala Gly Ala Lys Arg Thr Leu Thr Tyr 
        35                  40                  45              

Gly Glu Leu Arg Arg Glu Ser Leu Arg Leu Ala Gln Ser Leu His Asp 
    50                  55                  60                  

Leu Gly Leu Arg Lys Gly Asp Arg Val Leu Val Leu Met Pro Arg Arg 
65                  70                  75                  80  

Pro Glu Thr Tyr Ala Val Tyr Leu Ala Ile Leu Ser Leu Gly Ala Val 
                85                  90                  95      

Val Leu Pro Gly Ser Glu Leu Leu Met Pro Asn Asp Ile Ala Tyr Arg 
            100                 105                 110         

Leu Arg His Ala Glu Ala Lys Gly Val Ile Ala His Ala Ala Leu Ala 
        115                 120                 125             

Glu Arg Ala Glu Ala Ala Ile Ala Glu Ala Pro Trp Val Gln Leu Arg 
    130                 135                 140                 

Val Val Val Glu Gly Pro Arg Glu Gly Trp Ile Ala Tyr Asp Asp Leu 
145                 150                 155                 160 

Val Arg Gly Ala Pro Arg Glu Trp Asp Val Val Pro Thr Arg Arg Asp 
                165                 170                 175     

Asp Leu Ala Phe Leu Ser Tyr Thr Ser Gly Thr Thr Gly Tyr Pro Lys 
            180                 185                 190         

Gly Val Met His Val His Gly Trp Ala Tyr Ala His Trp His Ile Ala 
        195                 200                 205             

Ala Lys Arg Trp Leu Gly Ile Glu Pro Asp Asp Val Val Trp Ala Thr 
    210                 215                 220                 

Ala Gly Pro Gly Trp Ala Lys Trp Ile Trp Ser Pro Phe Val Ala Thr 
225                 230                 235                 240 

Leu Met Ser Gly Ala Thr Gly Phe His Tyr Gly Gly Arg Phe Asp Ala 
                245                 250                 255     

Glu Thr Phe Leu Arg Leu Ile Asp Asp Glu Ala Val Asn Val Leu Cys 
            260                 265                 270         

Ala Thr Pro Thr Glu Tyr Arg Met Met Ala Lys Val Asp Gly Leu Asp 
        275                 280                 285             

Arg Phe Arg Leu Ser Ser Leu Arg Gln Ala Val Ser Ala Gly Glu Pro 
    290                 295                 300                 

Leu Asn Arg Glu Val Ile Asp Thr Phe Arg Arg His Phe Gln Val Thr 
305                 310                 315                 320 

Val Arg Asp Gly Tyr Gly Gln Thr Glu Asn Thr Leu Leu Val Ala Thr 
                325                 330                 335     

Cys Val Asp Thr Glu Val Arg Pro Gly Ser Met Gly Leu Pro Thr Val 
            340                 345                 350         

Glu Gly Ala Val Asp Ile Val Asp Asp Glu Gly Arg Pro Leu Pro Pro 
        355                 360                 365             

Gly Gln Val Gly Asp Ile Ala Val Arg Arg Asp Phe Pro Ala Leu Phe 
    370                 375                 380                 

Arg Gly Tyr Tyr Lys Asp Asp Glu Arg Thr Glu Ala Gln Phe Arg Gly 
385                 390                 395                 400 

Ala Trp Tyr Ile Thr Gly Asp Arg Ala Glu Lys Asp Glu Asp Gly Tyr 
                405                 410                 415     

Leu Trp Phe Ser Gly Arg Ala Asp Asp Ile Ile Ile Ser Ala Gly Tyr 
            420                 425                 430         

Thr Ile Gly Pro Phe Glu Val Glu Asp Ala Leu Val Lys His Pro Leu 
        435                 440                 445             

Val Arg Glu Cys Ala Ala Val Ser Ser Pro Asp Glu Val Arg Gly Ala 
    450                 455                 460                 

Ile Val Lys Ala Phe Val Val Leu Lys Asp Ala Asn Leu His Arg Glu 
465                 470                 475                 480 

Leu Ala Ser Asp Gly Glu Arg Arg Glu Ala Leu Val Arg Glu Leu Gln 
                485                 490                 495     

Glu His Val Lys Arg Ile Thr Ala Pro Tyr Lys Tyr Pro Arg Ala Ile 
            500                 505                 510         

Glu Phe Val Glu Asp Leu Pro Lys Thr Thr Ser Gly Lys Ile Arg Arg 
        515                 520                 525             

Val Glu Leu Arg Glu Arg Glu Trp Lys Arg His Arg Lys Leu Asn Glu 
    530                 535                 540                 

Glu Gln Gly Gly 
545             

<210>   1542
<211>   548
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1531

<400>   1542
Met Glu Pro Ser Gln Thr Ala Ala Phe Ala Glu Leu Leu Ala Pro Asp 
                5                   10                  15      

Val Phe Asn Ile Ala Ser Ala Ile Leu Asp Arg Asp Glu Ser Arg Arg 
            20                  25                  30          

Ala Leu Val Trp Arg Ser Glu Ala Gly Ala Lys Arg Thr Leu Thr Tyr 
        35                  40                  45              

Gly Glu Leu Arg Arg Glu Ser Leu Arg Leu Ala Gln Ser Leu His Asp 
    50                  55                  60                  

Leu Gly Leu Arg Lys Gly Asp Arg Val Leu Val Leu Met Pro Arg Arg 
65                  70                  75                  80  

Pro Glu Thr Tyr Ala Val Tyr Leu Ala Ile Leu Ser Leu Gly Ala Val 
                85                  90                  95      

Val Leu Pro Gly Ser Glu Leu Leu Met Pro Asn Asp Ile Ala Tyr Arg 
            100                 105                 110         

Leu Arg His Ala Glu Ala Lys Gly Val Ile Ala His Ala Ala Leu Ala 
        115                 120                 125             

Glu Arg Ala Glu Ala Ala Ile Ala Glu Ala Pro Trp Val Gln Leu Arg 
    130                 135                 140                 

Val Val Val Glu Gly Pro Arg Glu Gly Trp Leu Ala Tyr Asp Asp Leu 
145                 150                 155                 160 

Val Arg Gly Ala Pro Arg Glu Trp Asp Val Val Pro Thr Arg Arg Asp 
                165                 170                 175     

Asp Leu Ala Phe Leu Ser Tyr Thr Ser Gly Thr Thr Gly Tyr Pro Lys 
            180                 185                 190         

Gly Val Met His Val His Gly Trp Ala Tyr Ala His Trp His Ile Ala 
        195                 200                 205             

Ala Lys Arg Trp Leu Gly Ile Glu Pro Asp Asp Val Val Trp Ala Thr 
    210                 215                 220                 

Ala Gly Pro Gly Trp Ala Lys Trp Ile Trp Ser Pro Phe Val Ala Thr 
225                 230                 235                 240 

Leu Met Ser Gly Ala Thr Gly Phe His Tyr Gly Gly Arg Phe Asp Ala 
                245                 250                 255     

Glu Thr Phe Leu Arg Leu Ile Asp Asp Glu Ala Val Asn Val Leu Cys 
            260                 265                 270         

Ala Thr Pro Thr Glu Tyr Arg Met Met Ala Lys Val Asp Gly Leu Asp 
        275                 280                 285             

Arg Phe Arg Leu Ser Ser Leu Arg Gln Ala Val Ser Ala Gly Glu Pro 
    290                 295                 300                 

Leu Asn Arg Glu Val Ile Asp Thr Phe Arg Arg His Phe Gln Val Thr 
305                 310                 315                 320 

Val Arg Asp Gly Tyr Gly Gln Thr Glu Asn Thr Leu Leu Val Ala Thr 
                325                 330                 335     

Cys Val Asp Thr Glu Val Arg Pro Gly Ser Met Gly Leu Pro Thr Val 
            340                 345                 350         

Glu Gly Ala Val Asp Ile Val Asp Asp Glu Gly Arg Pro Leu Pro Pro 
        355                 360                 365             

Gly Gln Val Gly Asp Ile Ala Val Arg Arg Asp Phe Pro Ala Leu Phe 
    370                 375                 380                 

Arg Gly Tyr Tyr Lys Asp Asp Glu Arg Thr Glu Ala Gln Phe Arg Gly 
385                 390                 395                 400 

Ala Trp Tyr Ile Thr Gly Asp Arg Ala Glu Lys Asp Glu Asp Gly Tyr 
                405                 410                 415     

Leu Trp Phe Ser Gly Arg Ala Asp Asp Ile Ile Ile Ser Ala Gly Tyr 
            420                 425                 430         

Thr Ile Gly Pro Phe Glu Val Glu Asp Ala Leu Val Lys His Pro Leu 
        435                 440                 445             

Val Arg Glu Cys Ala Ala Val Ser Ser Pro Asp Glu Val Arg Gly Ala 
    450                 455                 460                 

Ile Val Lys Ala Phe Val Val Leu Lys Asp Ala Asn Leu His Arg Glu 
465                 470                 475                 480 

Leu Ala Ser Asp Gly Glu Arg Arg Glu Ala Leu Val Arg Glu Leu Gln 
                485                 490                 495     

Glu His Val Lys Arg Ile Thr Ala Pro Tyr Lys Tyr Pro Arg Ala Ile 
            500                 505                 510         

Glu Phe Val Glu Asp Leu Pro Lys Thr Thr Ser Gly Lys Ile Arg Arg 
        515                 520                 525             

Val Glu Leu Arg Glu Arg Glu Trp Lys Arg His Arg Lys Leu Gln Glu 
    530                 535                 540                 

Glu Gln Gly Gly 
545             

<210>   1543
<211>   1647
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1532

<400>   1543
atggagccat cccaaaccgc cgcatttgcg gagcttctgg cgccggacgt gttcaacatc       60

gcgagcgcca ttctggaccg ggacgaatcg aggcgcgcgc tcgtgtggcg ctcggaggcc      120

ggggcgaagc ggaccctgac gtacggcgag cttcgccgcg agtcccttcg cctggcgcaa      180

tctcttcacg atctcggcct tcgaaaaggc gaccgggtcc tggtgttgat gccgcgccgc      240

ccggagacct acgccgtgta tctcgccatc ctctcgctcg gcgccgtggt tctgcccgga      300

tcggagttac tcatgccgaa cgacatcgcc tatcgcctga gacacgcgga ggcgaagggc      360

gtgatcgccc acgcggcgct cgcggagcgg gccgaggcgg ccatcgccga ggcgccgtgg      420

gtgcagttgc gcgtcgtggt cgagggcccg cgcgaaggct ggctggcgta tgacgacctc      480

gtgcgcggcg cccccaggga gtgggacgtg gttccgacgc gtcgggacga tctcgccttc      540

ctgtcgtaca cctccgggac gacgggctac cccaagggtg tgatgcatgt ccacggctgg      600

gcgtacgcgc actggcacat cgccgcgaag cgctggctcg gcattgagcc tgacgacgtg      660

gtgtgggcca ccgccgggcc cggatgggcg aagtggatct ggagcccctt cgtcgccacg      720

ctcatgtcgg gcgccacagg cttccactac ggtggccgat ttgacgcgga gacgtttctt      780

cggctcatcg acgacgaagc ggtcaatgtg ctctgcgcga cgcccacgga ataccggatg      840

atggccaagg tggacggcct cgaacggttt cgcctctcgt cgctgcgcca ggcggtgagc      900

gcgggcgagc ctcttaaccg agaagtcatt gacacgttcc gccgccattt tcaggtcacc      960

gtgcgcgacg gctacgggca gacggagaac acgcttctcg ttgcgacgtg cgtcgatacg     1020

gaggtgcgcc ccggttcgat ggggctgccg acggtcgaag gggccgtcga cattgtcgac     1080

gacgagggca ggccacttcc tccgggccag gtgggggaca tcgcggtcag gcgagacttc     1140

ccggccctct tccggggtta ctacaaggac gacgagcgga ccgaggctca gtttcggggc     1200

gcgtggtaca tcacgggcga tcgcgccgag aaagacgagg acggatatct gtggttcagc     1260

ggccgcgcgg acgacatcat catcagcgct ggatacacca tcgggccgtt tgaggtcgag     1320

gacgcgctcg tgaaacatcc gctggtgcgc gagtgcgcag cggtgtcgag cccggatgag     1380

gtgcggggcg caattgtgaa ggcgttcgtc gtcctcaagg atgccaactt gcaccgagag     1440

ctggcatccg acggcgagcg acgcgaggcg ctggtgcgag aactgcagga gcacgtgaag     1500

cggatcaccg cgccctacaa gtatccgcgc gcaattgagt ttgtggagga tttgccgaag     1560

acgacgtcgg ggaagattcg ccgcgtcgag ctcagggagc gcgagtggaa gcggcaccgc     1620

aagctgaacg aggagcaggg agggtga                                         1647


<210>   1544
<211>   1647
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1532

<400>   1544
atggagccat cccaaaccgc cgcatttgcg gagcttctgg cgccggacgt gttcaacatc       60

gcgagcgcca ttctggacaa agacgaatcg aggcgcgcgc tcgtgtggcg ctcggaggcc      120

ggggcgaagc ggaccctgac gtacggcgag cttcgccgcg agtcccttcg cctggcgcaa      180

tctcttcacg atctcggcct tcgaaaaggc gaccgggtcc tggtgttgat gccgcgccgc      240

ccggagacct acgccgtgta tctcgccatc ctctcgctcg gcgccgtggt tctgcccgga      300

tcggagttac tcatgccgaa cgacatcgcc tatcgcctga gacacgcgga ggcgaagggc      360

gtgatcgccc acgcggcgct cgcggagcgg gccgaggcgg ccatcgccga ggcgccgtgg      420

gtgcagttgc gcgtcgtggt cgagggcccg cgcgaaggct ggctggcgta tgacgacctc      480

gtgcgcggcg cccccaggga gtgggacgtg gttccgacgc gtcgggacga tctcgccttc      540

ctgtcgtaca cctccgggac gacgggctac cccaagggtg tgatgcatgt ccacggctgg      600

gcgtacgcgc actggcacat cgccgcgaag cgctggctcg gcattgagcc tgacgacgtg      660

gtgtgggcca ccgccgggcc cggatgggcg aagtggatct ggagcccctt cgtcgccacg      720

ctcatgtcgg gcgccacagg cttccactac ggtggccgat ttgacgcgga gacgtttctt      780

cggctcatcg acgacgaagc ggtcaatgtg ctctgcgcga cgcccacgga ataccggatg      840

atggccaagg tggacggcct cgatcggttt cgcctctcgt cgctgcgcca ggcggtgagc      900

gcgggcgagc ctcttaaccg agaagtcatt gacacgttcc gccgccattt tcaggtcacc      960

gtgcgcgacg gctacgggca gacggagaac acgcttctcg ttgcgacgtg cgtcgatacg     1020

gaggtgcgcc ccggttcgat ggggctgccg acggtcgaag gggccgtcga cattgtcgac     1080

gacgagggca ggccacttcc tccgggccag gtgggggaca tcgcggtcag gcgagacttc     1140

ccggccctct tccggggtta ctacaaggac gacgagcgga ccgaggctca gtttcggggc     1200

gcgtggtaca tcacgggcga tcgcgccgag aaagacgagg acggatatct gtggttcagc     1260

ggccgcgcgg acgacatcat catcagcgct ggatacacca tcgggccgtt tgaggtcgag     1320

gacgcgctcg tgaaacatcc gctggtgcgc gagtgcgcag cggtgtcgag cccggatgag     1380

gtgcggggcg caattgtgaa ggcgttcgtc gtcctcaagg atgccaactt gcaccgagag     1440

ctggcatccg acggcgagcg acgcgaggcg ctggtgcgag aactgcagga gcacgtgaag     1500

cggatcaccg cgccctacaa gtatccgcgc gcaattgagt ttgtggagga tttgccgaag     1560

acgacgtcgg ggaagattcg ccgcgtcgag ctcagggagc gcgagtggaa gcggcaccgc     1620

aagctgaacg aggagcaggg agggtga                                         1647


<210>   1545
<211>   1647
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1532

<400>   1545
atggagccat cccaaaccgc cgcatttgcg gagcttctgg cgccggacgt gttcaacatc       60

gcgagcgcca ttctggaccg ggacgaatcg aggcgcgcgc tcgtgtggcg ctcggaggcc      120

ggggcgaagc ggaccctgac gtacggcgag cttcgccgcg agtcccttcg cctggcgcaa      180

tctcttcacg atctcggcct tcgaaaaggc gaccgggtcc tggtgttgat gccgcgccgc      240

ccggagacct acgccgtgta tctcgccatc ctctcgctcg gcgccgtggt tctgcccgga      300

tcggagttac tcatgccgaa cgacatcgcc tatcgcctga gacacgcgga ggcgaagggc      360

gtgatcgccc acgcggcgct cgcggagcgg gccgaggcgg ccatcgccga ggcgccgtgg      420

gtgcagttgc gcgtcgtggt cgagggcccg cgcgaaggct ggctggcgta tgacgacctc      480

gtgcgcggcg cccccaggga gtgggacgtg gttccgacgc gtcgggacga tctcgccttc      540

ctgtcgtaca cctccgggac gacgggctac cccaagggtg tgatgcatgt ccacggctgg      600

gcgtacgcgc actggcacat cgccgcgaag cgctggctcg gcattgagcc tgacgacgtg      660

gtgtgggcca ccgccgggcc cggatgggcg aagtggatct ggagcccctt cgtcgccacg      720

ctcatgtcgg gcgccacagg cttccactac ggtggccgat ttgacgcgga gacgtttctt      780

cggctcatcg acgacgaagc ggtcaatgtg ctctgcgcga cgcccacgga ataccggatg      840

atggccaagg tggacggcct cgatcggttt cgcctctcgt cgctgcgcca ggcggtgagc      900

gcgggcgagc ctcttaaccg agaagtcatt gacacgttcc gccgccattt tcaggtcacc      960

gtgcgcgacg gctacgggca gacggagaac acgcttctcg ttgcgacgtg cgtcgatacg     1020

gaggtgcgcc ccggttcgat ggggctgccg acggtcgaag gggccgtcga cattgtcgac     1080

gacgagggca ggccacttcc tccgggccag gtgggggaca tcgcggtcag gcgagacttc     1140

ccggccctct tccggggtta ctacaaggac gacgagcgga ccgaggctca gtttcggggc     1200

gcgtggtaca tcacgggcga tcgcgccgag aaagacgagg acggatatct gtggttcagc     1260

ggccgcgcgg acgacatcat catcagcgct ggatacacca tcgggccgtt tgaggtcgag     1320

gacgcgctcg tgaaacatcc gctggtgcgc gagtgcgcag cggtgtcgag cccggatgag     1380

gtgcggggcg caattgtgaa ggcgttcgtc gtcctcaagg atgccaactt gcacaaagag     1440

ctggcatccg acggcgagcg acgcgaggcg ctggtgcgag aactgcagga gcacgtgaag     1500

cggatcaccg cgccctacaa gtatccgcgc gcaattgagt ttgtggagga tttgccgaag     1560

acgacgtcgg ggaagattcg ccgcgtcgag ctcagggagc gcgagtggaa gcggcaccgc     1620

aagctgaacg aggagcaggg agggtga                                         1647


<210>   1546
<211>   1647
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1532

<400>   1546
atggagccat cccaaaccgc cgcatttgcg gagcttctgg cgccggacgt gttcaacatc       60

gcgagcgcca ttctggaccg ggacgaatcg aggcgcgcgc tcgtgtggcg ctcggaggcc      120

ggggcgaagc ggaccctgac gtacggcgag cttcgccgcg agtcccttcg cctggcgcaa      180

tctcttcacg atctcggcct tcgaaaaggc gaccgggtcc tggtgttgat gccgcgccgc      240

ccggagacct acgccgtgta tctcgccatc ctctcgctcg gcgccgtggt tctgcccgga      300

tcggagttac tcatgccgaa cgacatcgcc tatcgcctga gacacgcgga ggcgaagggc      360

gtgatcgccc acgcggcgct cgcggagcgg gccgaggcgg ccatcgccga ggcgccgtgg      420

gtgcagttgc gcgtcgtggt cgagggcccg cgcgaaggct ggattgcgta tgacgacctc      480

gtgcgcggcg cccccaggga gtgggacgtg gttccgacgc gtcgggacga tctcgccttc      540

ctgtcgtaca cctccgggac gacgggctac cccaagggtg tgatgcatgt ccacggctgg      600

gcgtacgcgc actggcacat cgccgcgaag cgctggctcg gcattgagcc tgacgacgtg      660

gtgtgggcca ccgccgggcc cggatgggcg aagtggatct ggagcccctt cgtcgccacg      720

ctcatgtcgg gcgccacagg cttccactac ggtggccgat ttgacgcgga gacgtttctt      780

cggctcatcg acgacgaagc ggtcaatgtg ctctgcgcga cgcccacgga ataccggatg      840

atggccaagg tggacggcct cgatcggttt cgcctctcgt cgctgcgcca ggcggtgagc      900

gcgggcgagc ctcttaaccg agaagtcatt gacacgttcc gccgccattt tcaggtcacc      960

gtgcgcgacg gctacgggca gacggagaac acgcttctcg ttgcgacgtg cgtcgatacg     1020

gaggtgcgcc ccggttcgat ggggctgccg acggtcgaag gggccgtcga cattgtcgac     1080

gacgagggca ggccacttcc tccgggccag gtgggggaca tcgcggtcag gcgagacttc     1140

ccggccctct tccggggtta ctacaaggac gacgagcgga ccgaggctca gtttcggggc     1200

gcgtggtaca tcacgggcga tcgcgccgag aaagacgagg acggatatct gtggttcagc     1260

ggccgcgcgg acgacatcat catcagcgct ggatacacca tcgggccgtt tgaggtcgag     1320

gacgcgctcg tgaaacatcc gctggtgcgc gagtgcgcag cggtgtcgag cccggatgag     1380

gtgcggggcg caattgtgaa ggcgttcgtc gtcctcaagg atgccaactt gcaccgagag     1440

ctggcatccg acggcgagcg acgcgaggcg ctggtgcgag aactgcagga gcacgtgaag     1500

cggatcaccg cgccctacaa gtatccgcgc gcaattgagt ttgtggagga tttgccgaag     1560

acgacgtcgg ggaagattcg ccgcgtcgag ctcagggagc gcgagtggaa gcggcaccgc     1620

aagctgaacg aggagcaggg agggtga                                         1647


<210>   1547
<211>   1647
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1532

<400>   1547
atggagccat cccaaaccgc cgcatttgcg gagcttctgg cgccggacgt gttcaacatc       60

gcgagcgcca ttctggaccg ggacgaatcg aggcgcgcgc tcgtgtggcg ctcggaggcc      120

ggggcgaagc ggaccctgac gtacggcgag cttcgccgcg agtcccttcg cctggcgcaa      180

tctcttcacg atctcggcct tcgaaaaggc gaccgggtcc tggtgttgat gccgcgccgc      240

ccggagacct acgccgtgta tctcgccatc ctctcgctcg gcgccgtggt tctgcccgga      300

tcggagttac tcatgccgaa cgacatcgcc tatcgcctga gacacgcgga ggcgaagggc      360

gtgatcgccc acgcggcgct cgcggagcgg gccgaggcgg ccatcgccga ggcgccgtgg      420

gtgcagttgc gcgtcgtggt cgagggcccg cgcgaaggct ggctggcgta tgacgacctc      480

gtgcgcggcg cccccaggga gtgggacgtg gttccgacgc gtcgggacga tctcgccttc      540

ctgtcgtaca cctccgggac gacgggctac cccaagggtg tgatgcatgt ccacggctgg      600

gcgtacgcgc actggcacat cgccgcgaag cgctggctcg gcattgagcc tgacgacgtg      660

gtgtgggcca ccgccgggcc cggatgggcg aagtggatct ggagcccctt cgtcgccacg      720

ctcatgtcgg gcgccacagg cttccactac ggtggccgat ttgacgcgga gacgtttctt      780

cggctcatcg acgacgaagc ggtcaatgtg ctctgcgcga cgcccacgga ataccggatg      840

atggccaagg tggacggcct cgatcggttt cgcctctcgt cgctgcgcca ggcggtgagc      900

gcgggcgagc ctcttaaccg agaagtcatt gacacgttcc gccgccattt tcaggtcacc      960

gtgcgcgacg gctacgggca gacggagaac acgcttctcg ttgcgacgtg cgtcgatacg     1020

gaggtgcgcc ccggttcgat ggggctgccg acggtcgaag gggccgtcga cattgtcgac     1080

gacgagggca ggccacttcc tccgggccag gtgggggaca tcgcggtcag gcgagacttc     1140

ccggccctct tccggggtta ctacaaggac gacgagcgga ccgaggctca gtttcggggc     1200

gcgtggtaca tcacgggcga tcgcgccgag aaagacgagg acggatatct gtggttcagc     1260

ggccgcgcgg acgacatcat catcagcgct ggatacacca tcgggccgtt tgaggtcgag     1320

gacgcgctcg tgaaacatcc gctggtgcgc gagtgcgcag cggtgtcgag cccggatgag     1380

gtgcggggcg caattgtgaa ggcgttcgtc gtcctcaagg atgccaactt gcaccgagag     1440

ctggcatccg acggcgagcg acgcgaggcg ctggtgcgag aactgcagga gcacgtgaag     1500

cggatcaccg cgccctacaa gtatccgcgc gcaattgagt ttgtggagga tttgccgaag     1560

acgacgtcgg ggaagattcg ccgcgtcgag ctcagggagc gcgagtggaa gcggcaccgc     1620

aagctgcaag aggagcaggg agggtga                                         1647


<210>   1548
<211>   499
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1548
Met Arg Arg Met His Arg Phe Glu Pro Cys Leu Asn Phe Ile Gly Gly 
                5                   10                  15      

Arg Trp Arg Glu Pro Lys Thr Gly Gln Tyr Gly Asp Asn Val Asn Pro 
            20                  25                  30          

Ala Asn Gly Glu Val Leu Gly Val Trp Ala Arg Ser Gly Pro Asp Asp 
        35                  40                  45              

Leu Asp Asp Ala Val Arg Ala Ala Arg Glu Ala Gln Ala Ala Trp Arg 
    50                  55                  60                  

Leu Val Pro Ala Pro Glu Arg Ala Lys Val Leu Arg Arg Val Ala Asp 
65                  70                  75                  80  

Leu Leu Arg Asp Arg Lys Asp Glu Ile Ala Arg Thr Leu Thr Met Glu 
                85                  90                  95      

Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu Val Gln Glu Ala Ile 
            100                 105                 110         

Asp Met Ala Glu Tyr Met Ala Gly Glu Gly Arg Arg Leu Phe Gly Gln 
        115                 120                 125             

Thr Thr Pro Ser Glu Leu Pro Asp Lys Phe Ala Met Ser Val Arg Val 
    130                 135                 140                 

Pro Val Gly Val Val Gly Ile Ile Thr Pro Trp Asn Phe Pro Ile Ala 
145                 150                 155                 160 

Ile Ala Ser Trp Lys Ser Leu Pro Ala Ile Val Ala Gly Asn Ala Val 
                165                 170                 175     

Val Trp Lys Pro Ala Glu Glu Thr Pro Leu Thr Ala Arg Ala Phe Val 
            180                 185                 190         

Glu Val Tyr Gln Glu Ala Gly Leu Pro Ala Gly Val Leu Asn Val Val 
        195                 200                 205             

Phe Gly Asp Gly Pro Val Val Gly Glu Ala Met Leu His His Pro Gly 
    210                 215                 220                 

Ile Asp Val Ile Ser Phe Thr Gly Ser Thr Glu Thr Gly Arg His Ile 
225                 230                 235                 240 

Ala Ser Arg Ala Gly Ala Asn Leu Lys Arg Val Ser Leu Glu Met Gly 
                245                 250                 255     

Gly Lys Asn Ala Ile Thr Val Leu Ala Asp Ala Asp Leu Asp Leu Ala 
            260                 265                 270         

Val Asp Ala Ile Leu Trp Ser Ala Tyr Gly Thr Ser Gly Gln Arg Cys 
        275                 280                 285             

Thr Ala Ala Ser Arg Val Ile Val Glu Arg Glu Ala Glu Glu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Leu Leu Pro Arg Val Gln Ala Leu Arg Val Gly Asp Gly 
305                 310                 315                 320 

Leu Asp Pro Ala Val Asn Val Gly Pro Val Ile His Glu Glu Ala Leu 
                325                 330                 335     

Ala Lys Ile Asp Arg Tyr Val Arg Leu Gly Val Asp Glu Gly Ala Arg 
            340                 345                 350         

Leu Leu Thr Gly Gly Arg Arg Leu Thr Glu Gly Pro Leu Ala Arg Gly 
        355                 360                 365             

Phe Tyr Tyr Ala Pro Thr Val Phe Ala Gly Val Arg Pro Asp Met Arg 
    370                 375                 380                 

Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Cys Val Met Ala Val 
385                 390                 395                 400 

Asp Ser Phe Glu Glu Ala Ile Arg Val Asn Asn Gly Val Arg Tyr Gly 
                405                 410                 415     

Leu Ser Ala Ser Ile Phe Thr Arg Asp Val Asn Arg Val Phe Arg Ala 
            420                 425                 430         

Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Val Asn Ala Gly Thr Thr 
        435                 440                 445             

Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr Lys Ala Thr Gly Asn 
    450                 455                 460                 

Gly His Arg Asp Ser Gly Gln Ala Ala Leu Asp Val Phe Thr Glu Trp 
465                 470                 475                 480 

Lys Thr Val Tyr Val Asp Tyr Ser Gly Arg Leu Gln Arg Ala Gln Ile 
                485                 490                 495     

Asp Asn Asn 
            

<210>   1549
<211>   1500
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1549
gtgaggcgca tgcatcggtt tgagccttgt ctgaatttca tcggcggcag gtggcgcgag       60

cccaagacgg ggcagtacgg ggacaacgtc aaccccgcaa acggcgaggt gctcggggtg      120

tgggcgagat cgggcccgga cgatctcgac gacgccgtgc gggcggcccg cgaggcgcag      180

gccgcgtggc gcctggtgcc cgctccggag cgcgcgaagg tgctgcggcg cgtcgcggat      240

ctgctgcggg atcgcaagga cgagatcgcg cggacgctga caatggagat gggcaaggtc      300

atcgaggagg cgcgcggcga ggtgcaggag gccatcgaca tggccgagta catggcgggc      360

gaggggcgaa ggctgttcgg ccagacgacg ccctcggaac ttcccgacaa gttcgccatg      420

agcgtgcgcg ttccggtggg cgtggtgggg atcatcacgc cgtggaactt ccccatcgcc      480

atcgcgtcgt ggaagtcgct tccggccatc gtcgccggca acgccgtggt gtggaagccc      540

gcggaggaga caccgctcac cgcgcgggcg ttcgtggagg tgtatcagga ggccgggctg      600

cctgcgggcg ttctgaacgt ggtgttcggc gatggccccg tggtcggcga ggcgatgctc      660

catcaccccg ggatcgacgt catctccttc accggatcga cggagacggg gcggcacatc      720

gcgagccgtg cgggtgcgaa tctgaagcgc gtgtccctcg agatgggcgg caaaaacgcc      780

atcacggtgc tcgccgacgc ggacctggac ctcgccgtgg acgccatcct ctggagtgcc      840

tacggcacga gcggccagcg gtgcaccgcg gcgagccgcg tgatcgtgga gcgcgaggcg      900

gaggaagcgt tgctcgctcg cttgctgccg cgcgtgcagg cgctccgcgt cggcgacggg      960

ctggatccgg ccgtcaacgt cgggcccgtc atccacgagg aagccctcgc gaagatcgac     1020

cggtacgtgc ggctcggcgt ggacgagggt gcgcggctct tgactggcgg ccgcaggctg     1080

acggagggcc cgctggcgcg cggcttttac tatgcgccga ccgtgttcgc cggcgtccgc     1140

cccgacatgc gcatcgcgca ggaggagatc ttcggcccgg tgctctgcgt gatggccgtc     1200

gactcgttcg aggaagccat ccgcgtcaac aacggggttc gctacgggct ctcggccagc     1260

atcttcacgc gcgacgtcaa ccgcgtgttt cgcgccatgc gcgatctcga caccgggatc     1320

gtgtacgtca acgcgggcac gacgggcgcc gaaattcacc tgccgttcgg cggtaccaag     1380

gccaccggaa acgggcaccg agattccggc caggccgcct tggacgtctt cacggagtgg     1440

aagaccgtgt acgtcgatta cagcggccgg ctgcagcgcg cgcagatcga caacaactga     1500


<210>   1550
<211>   488
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1550
Asn Tyr Ile Asn Gly Glu Trp Lys Glu Pro Ser Thr Gly Gln Phe Ala 
                5                   10                  15      

Pro Val Ile Asn Pro Ala Thr Gly Glu Thr Ile Ala Glu Val Ala Met 
            20                  25                  30          

Ser Gly Pro Asn Asp Ile Asp Glu Ala Val Gln Ala Ala Lys Glu Ala 
        35                  40                  45              

Gln Lys Gln Trp Ala Leu Val Pro Ala Pro Lys Arg Ala Glu Ile Leu 
    50                  55                  60                  

Tyr Lys Val Gly Met Leu Leu Lys Glu Arg Lys Glu Gln Leu Ala Arg 
65                  70                  75                  80  

Met Leu Thr Met Glu Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu 
                85                  90                  95      

Val Gln Glu Gly Ile Asp Met Ala Phe Tyr Met Ala Gly Glu Gly Arg 
            100                 105                 110         

Arg Leu Phe Gly Asp Thr Thr Pro Ser Glu Leu Lys Asp Lys Phe Ala 
        115                 120                 125             

Met Ser Val Arg Val Pro Val Gly Val Val Gly Ile Ile Thr Pro Trp 
    130                 135                 140                 

Asn Phe Pro Ile Ala Ile Ala Thr Trp Lys Ser Phe Pro Ala Ile Val 
145                 150                 155                 160 

Ala Gly Asn Ala Val Val Trp Lys Pro Ala Pro Glu Thr Pro Ile Met 
                165                 170                 175     

Ala Gln Glu Leu Ala Arg Ile Phe Glu Glu Ala Gly Leu Pro Pro Gly 
            180                 185                 190         

Val Phe His Val Val His Gly Asp Gly Pro Thr Val Gly Asn Ala Leu 
        195                 200                 205             

Val Glu His Pro Asp Val Lys Val Ile Ser Phe Thr Gly Ser Asn Glu 
    210                 215                 220                 

Val Gly Arg Met Ile Ala Glu Lys Cys Gly Arg Leu Leu Lys Lys Val 
225                 230                 235                 240 

Ser Leu Glu Met Gly Gly Lys Asn Ala Val Ile Val Met Asp Asp Ala 
                245                 250                 255     

Asp Leu Thr Leu Ala Val Asp Gly Ile Ile Trp Ser Ala Phe Gly Thr 
            260                 265                 270         

Ser Gly Gln Arg Cys Thr Ala Cys Ser Arg Val Ile Val His Glu Arg 
        275                 280                 285             

Val Lys Gln Glu Leu Glu Arg Arg Leu Leu Glu Ala Val Lys Thr Leu 
    290                 295                 300                 

Lys Ile Gly Asn Gly Leu Asp Glu Thr Val Lys Val Gly Pro Val Ile 
305                 310                 315                 320 

His Glu Glu Ala Leu Gln Lys Ile Asp Arg Tyr Val Arg Ile Gly Val 
                325                 330                 335     

Glu Glu Gly Ala Lys Leu Leu Val Gly Gly Tyr Ile Leu Arg Glu Gly 
            340                 345                 350         

Asp Tyr Ala Arg Gly Phe Tyr Tyr Ala Pro Thr Ile Phe Thr Asp Val 
        355                 360                 365             

Thr Pro Asn Met Arg Ile Ala Arg Glu Glu Ile Phe Gly Pro Val Val 
    370                 375                 380                 

Ser Ile Ile Ser Val Arg Ser Leu Asp Glu Ala Ile Ala Val Asn Asn 
385                 390                 395                 400 

Ser Val Asp Tyr Gly Leu Ser Ser Ala Ile Phe Thr Arg Asp Val Asn 
                405                 410                 415     

Asn Val Phe Arg Ala Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Val 
            420                 425                 430         

Asn Ala Gly Thr Thr Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr 
        435                 440                 445             

Lys Gly Thr Gly Asn Gly His Arg Asp Ser Gly Val Ala Ala Leu Asp 
    450                 455                 460                 

Val Phe Thr Glu Trp Arg Ser Ile Tyr Val Asp Phe Ser Gly Lys Leu 
465                 470                 475                 480 

Gln Arg Ala Gln Ile Asp Thr Asp 
                485             

<210>   1551
<211>   489
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1551
Leu Asn Phe Ile Asn Gly Lys Trp Gln Pro Ala Leu Ser Gly Gln Trp 
                5                   10                  15      

Ala Pro Val Ile Asn Pro Ala Asn Gly Glu Thr Ile Gly Glu Val Ala 
            20                  25                  30          

Leu Ser Ala Ala Ala Asp Val Asp Ala Ala Val Lys Ala Ala Lys Ala 
        35                  40                  45              

Ala Gln Lys Lys Trp Ala Leu Val Pro Ala Pro Lys Arg Ala Asp Val 
    50                  55                  60                  

Leu Tyr Lys Val Gly Leu Leu Leu Lys Glu Arg Lys Glu Gln Leu Ala 
65                  70                  75                  80  

Arg Leu Leu Thr Met Glu Met Gly Lys Val Ile Glu Glu Ala Arg Gly 
                85                  90                  95      

Glu Val Gln Glu Gly Ile Asp Met Ala Phe Tyr Met Ala Gly Glu Gly 
            100                 105                 110         

Arg Arg Leu Phe Gly Asp Thr Thr Pro Ser Glu Leu Lys Asp Lys Phe 
        115                 120                 125             

Ala Met Ser Val Arg Val Pro Val Gly Val Val Gly Ile Ile Thr Pro 
    130                 135                 140                 

Trp Asn Phe Pro Ile Ala Ile Ala Thr Trp Lys Ser Phe Pro Ala Ile 
145                 150                 155                 160 

Val Ala Gly Asn Ala Val Val Trp Lys Pro Ala Leu Glu Thr Pro Phe 
                165                 170                 175     

Met Ala Arg Glu Leu Ala Ala Ile Phe Thr Glu Ala Gly Leu Pro Asp 
            180                 185                 190         

Gly Val Phe Asn Val Val His Gly Asp Gly Pro Thr Ala Gly Asn Ala 
        195                 200                 205             

Leu Val Glu His Pro Asp Val Pro Val Ile Ser Phe Thr Gly Ser Asn 
    210                 215                 220                 

Glu Val Gly Arg Gln Ile Ala Glu Lys Cys Gly Arg Leu Leu Lys Lys 
225                 230                 235                 240 

Val Ser Leu Glu Met Gly Gly Lys Asn Ala Val Ile Val Met Asp Asp 
                245                 250                 255     

Ala Asp Leu Thr Leu Ala Val Asp Gly Ile Val Trp Ser Ala Phe Gly 
            260                 265                 270         

Thr Ser Gly Gln Arg Cys Thr Ala Cys Ser Arg Val Ile Val His Glu 
        275                 280                 285             

Arg Val Lys Gln Glu Leu Glu Trp Arg Leu Leu Glu Ala Val Lys Thr 
    290                 295                 300                 

Leu Lys Ile Gly Asp Gly Leu Asp Glu Thr Val Lys Val Gly Pro Val 
305                 310                 315                 320 

Ile His Glu Glu Ala Leu Gln Lys Ile Glu Arg Tyr Val His Ile Gly 
                325                 330                 335     

Arg Glu Glu Gly Ala Lys Leu Leu Val Gly Gly His Ile Leu Ser Asp 
            340                 345                 350         

Gly Asp Tyr Ala Arg Gly Phe Tyr Tyr Ala Pro Thr Ile Phe Thr Asp 
        355                 360                 365             

Val Thr Pro Asp Met Arg Ile Ala Arg Glu Glu Ile Phe Gly Pro Val 
    370                 375                 380                 

Val Ser Ile Ile Ser Val Arg Ser Leu Asp Glu Ala Ile Ala Val Asn 
385                 390                 395                 400 

Asn Cys Val Asp Tyr Gly Leu Ser Ser Ala Ile Phe Thr Arg Asp Val 
                405                 410                 415     

Asn Asn Val Phe Arg Ala Met Arg Asp Leu Asp Thr Gly Ile Val Tyr 
            420                 425                 430         

Val Asn Ala Gly Thr Thr Gly Ala Glu Ile His Leu Pro Phe Gly Gly 
        435                 440                 445             

Thr Lys Gly Thr Gly Asn Gly His Arg Asp Ser Gly Val Ala Ala Leu 
    450                 455                 460                 

Asp Val Phe Thr Glu Trp Arg Ser Ile Tyr Val Asp Phe Ser Gly Lys 
465                 470                 475                 480 

Leu Gln Arg Ala Gln Ile Asp Thr Asp 
                485                 

<210>   1552
<211>   488
<212>   PRT
<213>   Bacillus coagulans 36D1

<400>   1552
Glu Lys Tyr Leu Asn Tyr Ile Asp Gly Glu Trp Cys Glu Pro Ser Thr 
                5                   10                  15      

Gly Lys Phe Ala Pro Val Val Asn Pro Ala Asn Gly Lys Thr Leu Gly 
            20                  25                  30          

Glu Val Ala Gln Ser Ala Glu Pro Asp Leu Asp Arg Ala Val Gln Ala 
        35                  40                  45              

Ala Lys Ser Ala Gln Ser Val Trp Arg Leu Val Pro Ala Pro Glu Arg 
    50                  55                  60                  

Ala Asn Tyr Leu Tyr Lys Val Gly Glu Leu Leu Lys Gln Arg Lys Glu 
65                  70                  75                  80  

Gln Ile Ala Arg Thr Leu Thr Ser Glu Met Gly Lys Val Ile Asp Glu 
                85                  90                  95      

Ala Arg Gly Glu Val Gln Glu Ala Ile Asp Met Ala Phe Tyr Met Ala 
            100                 105                 110         

Gly Glu Gly Arg Arg Gln Phe Gly Asp Thr Val Pro Ser Glu Leu Gln 
        115                 120                 125             

Asn Lys Phe Ala Met Ser Ile Arg Val Pro Val Gly Ile Ala Gly Leu 
    130                 135                 140                 

Ile Thr Pro Trp Asn Phe Pro Ile Ala Ile Ala Ser Trp Lys Ser Leu 
145                 150                 155                 160 

Pro Ala Leu Val Thr Gly Asn Ala Val Ile Trp Lys Pro Ala Thr Glu 
                165                 170                 175     

Thr Pro Ala Thr Ala Cys Ala Phe Val Lys Ile Tyr Glu Glu Ala Gly 
            180                 185                 190         

Leu Pro Lys Gly Leu Val Asn Leu Val His Gly Ser Gly Ser Val Ile 
        195                 200                 205             

Gly Glu Ala Met Val Glu His Pro Gly Ile Gly Leu Ile Ser Phe Thr 
    210                 215                 220                 

Gly Ser Asn Glu Val Gly Arg Lys Ile Asn Glu Arg Ala Gly Gly Leu 
225                 230                 235                 240 

Leu Lys Arg Thr Ser Leu Glu Met Gly Gly Lys Asn Ala Val Ile Val 
                245                 250                 255     

Met Asp Asp Ala Asp Leu Asp Leu Ala Val Asp Gly Ile Leu Trp Gly 
            260                 265                 270         

Ala Phe Gly Thr Ser Gly Gln Arg Cys Thr Ala Thr Ser Arg Val Ile 
        275                 280                 285             

Val His Lys Lys Ile Lys Asp Ala Leu Glu Glu Lys Leu Ile Arg Arg 
    290                 295                 300                 

Thr Ala Glu Leu Lys Ile Gly Asp Gly Leu Asp Glu Thr Val Ala Val 
305                 310                 315                 320 

Gly Pro Val Ile Asn Thr Glu Ala Leu Asn Arg Ile His Gln Tyr Val 
                325                 330                 335     

Glu Thr Gly Lys Lys Glu Gly Ala Arg Leu Leu Thr Gly Gly Arg Ile 
            340                 345                 350         

Leu Pro Gly Lys Gly Tyr Tyr Tyr Ala Pro Thr Val Phe Thr Asp Val 
        355                 360                 365             

Ser Pro Glu Met Val Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Val 
    370                 375                 380                 

Ser Ile Ile Pro Val Ala Ser Leu Glu Glu Ala Ile Val Val Asn Asn 
385                 390                 395                 400 

Ser Val Thr Phe Gly Leu Ser Ser Gly Ile Phe Thr Lys Asp Val Asn 
                405                 410                 415     

Lys Ala Phe Gln Ala Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Ile 
            420                 425                 430         

Asn Ala Gly Thr Thr Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr 
        435                 440                 445             

Lys Gly Thr Gly Asn Gly His Arg Asp Ser Gly Pro Ala Ala Leu Asp 
    450                 455                 460                 

Val Tyr Thr Glu Trp Lys Ala Val Tyr Val Asp Phe Ser Gly Lys Leu 
465                 470                 475                 480 

Gln Arg Ala Gln Ile Asp Asn Asn 
                485             

<210>   1553
<211>   456
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   1553
Ser Gly Pro Asn Asp Ile Asp Glu Ala Val Gln Ala Ala Lys Glu Ala 
                5                   10                  15      

Gln Arg Gln Trp Ala Leu Val Pro Ala Pro Lys Arg Ala Glu Ile Leu 
            20                  25                  30          

Tyr Lys Val Gly Met Leu Leu Lys Glu Arg Lys Glu Gln Leu Ala Arg 
        35                  40                  45              

Leu Leu Thr Met Glu Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu 
    50                  55                  60                  

Val Gln Glu Gly Ile Asp Met Ala Phe Tyr Met Ala Gly Glu Gly Arg 
65                  70                  75                  80  

Arg Leu Phe Gly Asp Thr Thr Pro Ser Glu Leu Lys Asp Lys Phe Ala 
                85                  90                  95      

Met Ser Val Arg Thr Pro Val Gly Val Val Gly Ile Ile Thr Pro Trp 
            100                 105                 110         

Asn Phe Pro Ile Ala Ile Ala Thr Trp Lys Ser Phe Pro Ala Ile Val 
        115                 120                 125             

Ala Gly Asn Ala Val Val Trp Lys Pro Ala Pro Glu Thr Pro Ile Met 
    130                 135                 140                 

Ala Gln Glu Leu Ala Arg Ile Phe Glu Glu Ala Gly Leu Pro Pro Gly 
145                 150                 155                 160 

Val Phe His Val Val His Gly Asp Gly Pro Thr Val Gly Asn Ala Leu 
                165                 170                 175     

Val Glu His Pro Asp Val Lys Val Ile Ser Phe Thr Gly Ser Asn Glu 
            180                 185                 190         

Val Gly Arg Met Ile Ala Glu Lys Cys Gly Arg Leu Leu Lys Lys Val 
        195                 200                 205             

Ser Leu Glu Met Gly Gly Lys Asn Ala Val Ile Val Met Asp Asp Ala 
    210                 215                 220                 

Asp Leu Thr Leu Ala Val Asp Gly Ile Ile Trp Ser Ala Phe Gly Thr 
225                 230                 235                 240 

Ser Gly Gln Arg Cys Thr Ala Cys Ser Arg Val Ile Val His Glu Arg 
                245                 250                 255     

Val Lys Gln Glu Phe Glu Arg Arg Leu Leu Glu Ala Val Lys Thr Leu 
            260                 265                 270         

Lys Ile Gly Asn Gly Leu Asp Glu Thr Val Lys Val Gly Pro Val Ile 
        275                 280                 285             

His Glu Glu Ala Leu Gln Lys Ile Asp Arg Tyr Val Arg Ile Gly Val 
    290                 295                 300                 

Glu Glu Gly Ala Lys Leu Leu Val Gly Gly Tyr Ile Leu Arg Glu Gly 
305                 310                 315                 320 

Asp Tyr Ala Arg Gly Phe Tyr Tyr Ala Pro Thr Ile Phe Thr Asp Val 
                325                 330                 335     

Thr Pro Asn Met Arg Ile Ala Arg Glu Glu Ile Phe Gly Pro Val Val 
            340                 345                 350         

Ser Ile Ile Ser Val Arg Ser Leu Asp Glu Ala Ile Ala Val Asn Asn 
        355                 360                 365             

Ser Val Asp Tyr Gly Leu Ser Ser Ala Ile Phe Thr Arg Asp Val Asn 
    370                 375                 380                 

Asn Val Phe Arg Ala Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Val 
385                 390                 395                 400 

Asn Ala Gly Thr Thr Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr 
                405                 410                 415     

Lys Gly Thr Gly Asn Gly His Arg Asp Ser Gly Val Ala Ala Leu Asp 
            420                 425                 430         

Val Phe Thr Glu Trp Arg Ser Ile Tyr Val Asp Phe Ser Gly Lys Leu 
        435                 440                 445             

Gln Arg Ala Gln Ile Asp Thr Asp 
    450                 455     

<210>   1554
<211>   486
<212>   PRT
<213>   Bacillus sp. B14905

<400>   1554
Asn Tyr Ile Gly Gly Lys Trp Ser Thr His Ser His Leu Gln Ser Ile 
                5                   10                  15      

Ala Val Thr Asn Pro Ala Asn Gly Glu Gln Leu Ala Thr Ile Pro Leu 
            20                  25                  30          

Ser Thr Ser Asn Glu Val Asp Glu Ala Val Val Ala Ala Lys Gln Ala 
        35                  40                  45              

Gln Lys Ser Trp Ala Leu Val Pro Ala Pro Lys Arg Ala Glu Phe Leu 
    50                  55                  60                  

Tyr Ala Ile Gly Gln Lys Met Lys Glu Lys Lys Glu Tyr Leu Ala Thr 
65                  70                  75                  80  

Val Leu Thr Lys Glu Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu 
                85                  90                  95      

Val Gln Glu Gly Ile Asp Met Ala Tyr Tyr Met Ala Gly Glu Gly Arg 
            100                 105                 110         

Arg Leu Phe Gly Glu Thr Thr Pro Ser Glu Leu Ala Asn Lys Phe Ala 
        115                 120                 125             

Met Ser Val Arg Ala Pro Ile Gly Val Val Ala Leu Ile Thr Pro Trp 
    130                 135                 140                 

Asn Phe Pro Val Ala Ile Ala Thr Trp Lys Ser Phe Pro Ala Ile Val 
145                 150                 155                 160 

Ala Gly Asn Thr Phe Ile Trp Lys Pro Ser Asn Glu Thr Pro Met Met 
                165                 170                 175     

Ala Cys Glu Met Gly Lys Ile Phe Glu Glu Val Gly Leu Pro Asp Gly 
            180                 185                 190         

Val Ala Asn Ile Val Phe Gly Thr Gly Pro Thr Val Gly Thr Ala Leu 
        195                 200                 205             

Ile Glu His Pro Asp Val Lys Val Ile Ser Phe Thr Gly Ser Thr Thr 
    210                 215                 220                 

Thr Gly Ser Lys Val Ala Glu Leu Gly Gly Lys His Leu Lys Lys Ile 
225                 230                 235                 240 

Ser Leu Glu Met Gly Gly Lys Asn Ala Val Ile Val Met Asp Asp Ala 
                245                 250                 255     

Asp Leu Gln Leu Ala Thr Glu Gly Ile Leu Trp Ser Ala Phe Gly Thr 
            260                 265                 270         

Ala Gly Gln Arg Cys Thr Ala Cys Ser Arg Val Ile Val His Lys Asp 
        275                 280                 285             

Val Lys Glu Gln Leu Glu Asn Arg Leu Leu Asp Glu Met Gln Lys Leu 
    290                 295                 300                 

Thr Ile Gly Asn Gly Leu Asp Glu Gly Val Lys Ile Gly Pro Val Ile 
305                 310                 315                 320 

Asn Lys Ala Ala Leu Glu Lys Ile Asn His Tyr Val Gln Ile Gly Lys 
                325                 330                 335     

Gln Glu Gly Ala Thr Leu Leu Ala Gly Gly Arg Ile Leu Asn Glu Pro 
            340                 345                 350         

Pro Tyr Asp Asn Gly Phe Tyr Tyr Glu Pro Thr Leu Phe Thr Asn Val 
        355                 360                 365             

Lys Pro Asp Met Ile Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Val 
    370                 375                 380                 

Ser Leu Ile Glu Val Ala Ser Leu Glu Glu Ala Ile Glu Val Asn Asn 
385                 390                 395                 400 

Gly Val Lys Phe Gly Leu Ser Ser Ser Ile Phe Ser Gln Asn Val Asn 
                405                 410                 415     

Thr Ile Phe Arg Ala Gln Arg Asp Leu Asp Thr Gly Ile Val Tyr Ile 
            420                 425                 430         

Asn Ala Gly Thr Thr Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr 
        435                 440                 445             

Lys Gly Thr Gly Asn Gly His Arg Asp Ser Gly Val Ala Ala Leu Asp 
    450                 455                 460                 

Val Tyr Thr Glu Trp Lys Ser Ile Tyr Val Asp Tyr Ser Gly Lys Leu 
465                 470                 475                 480 

Gln Arg Ala Gln Ile Asp 
                485     

<210>   1555
<211>   499
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1548

<400>   1555
Met Arg Arg Met His Arg Phe Glu Pro Cys Leu Asn Phe Ile Gly Gly 
                5                   10                  15      

Arg Trp Arg Glu Pro Lys Thr Gly Gln Tyr Gly Asp Asn Val Asn Pro 
            20                  25                  30          

Ala Asn Gly Glu Val Leu Gly Val Trp Ala Arg Ser Gly Pro Asp Asp 
        35                  40                  45              

Leu Asp Asp Ala Val Arg Ala Ala Arg Glu Ala Gln Ala Ala Trp Arg 
    50                  55                  60                  

Leu Val Pro Ala Pro Glu Arg Ala Lys Val Leu Arg Arg Val Ala Asp 
65                  70                  75                  80  

Leu Leu Arg Asp Arg Lys Asp Glu Ile Ala Arg Thr Leu Thr Met Glu 
                85                  90                  95      

Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu Val Gln Glu Ala Ile 
            100                 105                 110         

Asp Met Ala Glu Tyr Met Ala Gly Glu Gly Arg Arg Leu Phe Gly Gln 
        115                 120                 125             

Thr Thr Pro Ser Glu Leu Pro Asp Lys Phe Ala Met Ser Val Arg Val 
    130                 135                 140                 

Pro Val Gly Val Val Gly Ile Ile Thr Pro Trp Asn Phe Pro Ile Ala 
145                 150                 155                 160 

Ile Ala Ser Trp Lys Ser Leu Pro Ala Ile Val Ala Gly Asn Ala Val 
                165                 170                 175     

Val Trp Lys Pro Ala Glu Glu Thr Pro Leu Thr Ala Arg Ala Phe Val 
            180                 185                 190         

Glu Val Tyr Gln Glu Ala Gly Leu Pro Ala Gly Val Leu Asn Val Val 
        195                 200                 205             

Phe Gly Asp Gly Pro Val Val Gly Glu Ala Met Leu His His Pro Gly 
    210                 215                 220                 

Ile Asp Val Ile Ser Phe Thr Gly Ser Thr Glu Thr Gly Arg His Ile 
225                 230                 235                 240 

Ala Ser Arg Ala Gly Ala Asn Leu Lys Arg Val Ser Leu Glu Met Gly 
                245                 250                 255     

Gly Lys Asn Ala Ile Thr Val Leu Ala Asp Ala Asp Leu Asp Leu Ala 
            260                 265                 270         

Val Asp Ala Ile Leu Trp Ser Ala Tyr Gly Thr Ser Gly Gln Arg Cys 
        275                 280                 285             

Thr Ala Ala Ser Arg Val Ile Val Glu Arg Glu Ala Glu Glu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Leu Leu Pro Arg Val Gln Ala Leu Arg Val Gly Asp Gly 
305                 310                 315                 320 

Leu Asp Pro Ala Val Asn Val Gly Pro Val Ile His Glu Glu Ala Leu 
                325                 330                 335     

Ala Lys Ile Asp Arg Tyr Val Arg Ile Gly Val Asp Glu Gly Ala Arg 
            340                 345                 350         

Leu Leu Thr Gly Gly Arg Arg Leu Thr Glu Gly Pro Leu Ala Arg Gly 
        355                 360                 365             

Phe Tyr Tyr Ala Pro Thr Val Phe Ala Gly Val Arg Pro Asp Met Arg 
    370                 375                 380                 

Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Cys Val Met Ala Val 
385                 390                 395                 400 

Asp Ser Phe Glu Glu Ala Ile Arg Val Asn Asn Gly Val Arg Tyr Gly 
                405                 410                 415     

Leu Ser Ala Ser Ile Phe Thr Arg Asp Val Asn Arg Val Phe Arg Ala 
            420                 425                 430         

Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Val Asn Ala Gly Thr Thr 
        435                 440                 445             

Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr Lys Ala Thr Gly Asn 
    450                 455                 460                 

Gly His Arg Asp Ser Gly Gln Ala Ala Leu Asp Val Phe Thr Glu Trp 
465                 470                 475                 480 

Lys Thr Val Tyr Val Asp Tyr Ser Gly Arg Leu Gln Arg Ala Gln Ile 
                485                 490                 495     

Asp Asn Asn 
            

<210>   1556
<211>   499
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1548

<400>   1556
Met Arg Arg Met His Arg Phe Glu Pro Cys Leu Asn Phe Ile Gly Gly 
                5                   10                  15      

Arg Trp Arg Glu Pro Lys Thr Gly Gln Tyr Gly Asp Asn Val Asn Pro 
            20                  25                  30          

Ala Asn Gly Glu Val Leu Gly Val Trp Ala Arg Ser Gly Pro Asp Asp 
        35                  40                  45              

Leu Asp Asp Ala Val Arg Ala Ala Arg Glu Ala Gln Ala Ala Trp Arg 
    50                  55                  60                  

Leu Val Pro Ala Pro Glu Arg Ala Lys Val Leu Arg Arg Val Ala Asp 
65                  70                  75                  80  

Leu Leu Arg Asp Arg Lys Asp Glu Ile Ala Arg Thr Leu Thr Met Glu 
                85                  90                  95      

Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu Val Gln Glu Ala Ile 
            100                 105                 110         

Asp Met Ala Glu Tyr Met Ala Gly Glu Gly Arg Arg Ile Phe Gly Gln 
        115                 120                 125             

Thr Thr Pro Ser Glu Leu Pro Asp Lys Phe Ala Met Ser Val Arg Val 
    130                 135                 140                 

Pro Val Gly Val Val Gly Ile Ile Thr Pro Trp Asn Phe Pro Ile Ala 
145                 150                 155                 160 

Ile Ala Ser Trp Lys Ser Leu Pro Ala Ile Val Ala Gly Asn Ala Val 
                165                 170                 175     

Val Trp Lys Pro Ala Glu Glu Thr Pro Leu Thr Ala Arg Ala Phe Val 
            180                 185                 190         

Glu Val Tyr Gln Glu Ala Gly Leu Pro Ala Gly Val Leu Asn Val Val 
        195                 200                 205             

Phe Gly Asp Gly Pro Val Val Gly Glu Ala Met Leu His His Pro Gly 
    210                 215                 220                 

Ile Asp Val Ile Ser Phe Thr Gly Ser Thr Glu Thr Gly Arg His Ile 
225                 230                 235                 240 

Ala Ser Arg Ala Gly Ala Asn Leu Lys Arg Val Ser Leu Glu Met Gly 
                245                 250                 255     

Gly Lys Asn Ala Ile Thr Val Leu Ala Asp Ala Asp Leu Asp Leu Ala 
            260                 265                 270         

Val Asp Ala Ile Leu Trp Ser Ala Tyr Gly Thr Ser Gly Gln Arg Cys 
        275                 280                 285             

Thr Ala Ala Ser Arg Val Ile Val Glu Arg Glu Ala Glu Glu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Leu Leu Pro Arg Val Gln Ala Leu Arg Val Gly Asp Gly 
305                 310                 315                 320 

Leu Asp Pro Ala Val Asn Val Gly Pro Val Ile His Glu Glu Ala Leu 
                325                 330                 335     

Ala Lys Ile Asp Arg Tyr Val Arg Leu Gly Val Asp Glu Gly Ala Arg 
            340                 345                 350         

Leu Leu Thr Gly Gly Arg Arg Leu Thr Glu Gly Pro Leu Ala Arg Gly 
        355                 360                 365             

Phe Tyr Tyr Ala Pro Thr Val Phe Ala Gly Val Arg Pro Asp Met Arg 
    370                 375                 380                 

Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Cys Val Met Ala Val 
385                 390                 395                 400 

Asp Ser Phe Glu Glu Ala Ile Arg Val Asn Asn Gly Val Arg Tyr Gly 
                405                 410                 415     

Leu Ser Ala Ser Ile Phe Thr Arg Asp Val Asn Arg Val Phe Arg Ala 
            420                 425                 430         

Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Val Asn Ala Gly Thr Thr 
        435                 440                 445             

Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr Lys Ala Thr Gly Asn 
    450                 455                 460                 

Gly His Arg Asp Ser Gly Gln Ala Ala Leu Asp Val Phe Thr Glu Trp 
465                 470                 475                 480 

Lys Thr Val Tyr Val Asp Tyr Ser Gly Arg Leu Gln Arg Ala Gln Ile 
                485                 490                 495     

Asp Asn Asn 
            

<210>   1557
<211>   499
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1548

<400>   1557
Met Arg Arg Met His Arg Phe Glu Pro Cys Leu Asn Phe Ile Gly Gly 
                5                   10                  15      

Arg Trp Arg Glu Pro Lys Thr Gly Gln Tyr Gly Asp Asn Val Asn Pro 
            20                  25                  30          

Ala Asn Gly Glu Val Leu Gly Val Trp Ala Arg Ser Gly Pro Asp Asp 
        35                  40                  45              

Leu Asp Asp Ala Val Arg Ala Ala Arg Glu Ala Gln Ala Ala Trp Lys 
    50                  55                  60                  

Leu Val Pro Ala Pro Glu Arg Ala Lys Val Leu Arg Arg Val Ala Asp 
65                  70                  75                  80  

Leu Leu Arg Asp Arg Lys Asp Glu Ile Ala Arg Thr Leu Thr Met Glu 
                85                  90                  95      

Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu Val Gln Glu Ala Ile 
            100                 105                 110         

Asp Met Ala Glu Tyr Met Ala Gly Glu Gly Arg Arg Leu Phe Gly Gln 
        115                 120                 125             

Thr Thr Pro Ser Glu Leu Pro Asp Lys Phe Ala Met Ser Val Arg Val 
    130                 135                 140                 

Pro Val Gly Val Val Gly Ile Ile Thr Pro Trp Asn Phe Pro Ile Ala 
145                 150                 155                 160 

Ile Ala Ser Trp Lys Ser Leu Pro Ala Ile Val Ala Gly Asn Ala Val 
                165                 170                 175     

Val Trp Lys Pro Ala Glu Glu Thr Pro Leu Thr Ala Arg Ala Phe Val 
            180                 185                 190         

Glu Val Tyr Gln Glu Ala Gly Leu Pro Ala Gly Val Leu Asn Val Val 
        195                 200                 205             

Phe Gly Asp Gly Pro Val Val Gly Glu Ala Met Leu His His Pro Gly 
    210                 215                 220                 

Ile Asp Val Ile Ser Phe Thr Gly Ser Thr Glu Thr Gly Arg His Ile 
225                 230                 235                 240 

Ala Ser Arg Ala Gly Ala Asn Leu Lys Arg Val Ser Leu Glu Met Gly 
                245                 250                 255     

Gly Lys Asn Ala Ile Thr Val Leu Ala Asp Ala Asp Leu Asp Leu Ala 
            260                 265                 270         

Val Asp Ala Ile Leu Trp Ser Ala Tyr Gly Thr Ser Gly Gln Arg Cys 
        275                 280                 285             

Thr Ala Ala Ser Arg Val Ile Val Glu Arg Glu Ala Glu Glu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Leu Leu Pro Arg Val Gln Ala Leu Arg Val Gly Asp Gly 
305                 310                 315                 320 

Leu Asp Pro Ala Val Asn Val Gly Pro Val Ile His Glu Glu Ala Leu 
                325                 330                 335     

Ala Lys Ile Asp Arg Tyr Val Arg Leu Gly Val Asp Glu Gly Ala Arg 
            340                 345                 350         

Leu Leu Thr Gly Gly Arg Arg Leu Thr Glu Gly Pro Leu Ala Arg Gly 
        355                 360                 365             

Phe Tyr Tyr Ala Pro Thr Val Phe Ala Gly Val Arg Pro Asp Met Arg 
    370                 375                 380                 

Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Cys Val Met Ala Val 
385                 390                 395                 400 

Asp Ser Phe Glu Glu Ala Ile Arg Val Asn Asn Gly Val Arg Tyr Gly 
                405                 410                 415     

Leu Ser Ala Ser Ile Phe Thr Arg Asp Val Asn Arg Val Phe Arg Ala 
            420                 425                 430         

Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Val Asn Ala Gly Thr Thr 
        435                 440                 445             

Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr Lys Ala Thr Gly Asn 
    450                 455                 460                 

Gly His Arg Asp Ser Gly Gln Ala Ala Leu Asp Val Phe Thr Glu Trp 
465                 470                 475                 480 

Lys Thr Val Tyr Val Asp Tyr Ser Gly Arg Leu Gln Arg Ala Gln Ile 
                485                 490                 495     

Asp Asn Asn 
            

<210>   1558
<211>   499
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1548

<400>   1558
Met Arg Arg Met His Arg Phe Asp Pro Cys Leu Asn Phe Ile Gly Gly 
                5                   10                  15      

Arg Trp Arg Glu Pro Lys Thr Gly Gln Tyr Gly Asp Asn Val Asn Pro 
            20                  25                  30          

Ala Asn Gly Glu Val Leu Gly Val Trp Ala Arg Ser Gly Pro Asp Asp 
        35                  40                  45              

Leu Asp Asp Ala Val Arg Ala Ala Arg Glu Ala Gln Ala Ala Trp Arg 
    50                  55                  60                  

Leu Val Pro Ala Pro Glu Arg Ala Lys Val Leu Arg Arg Val Ala Asp 
65                  70                  75                  80  

Leu Leu Arg Asp Arg Lys Asp Glu Ile Ala Arg Thr Leu Thr Met Glu 
                85                  90                  95      

Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu Val Gln Glu Ala Ile 
            100                 105                 110         

Asp Met Ala Glu Tyr Met Ala Gly Glu Gly Arg Arg Leu Phe Gly Gln 
        115                 120                 125             

Thr Thr Pro Ser Glu Leu Pro Asp Lys Phe Ala Met Ser Val Arg Val 
    130                 135                 140                 

Pro Val Gly Val Val Gly Ile Ile Thr Pro Trp Asn Phe Pro Ile Ala 
145                 150                 155                 160 

Ile Ala Ser Trp Lys Ser Leu Pro Ala Ile Val Ala Gly Asn Ala Val 
                165                 170                 175     

Val Trp Lys Pro Ala Glu Glu Thr Pro Leu Thr Ala Arg Ala Phe Val 
            180                 185                 190         

Glu Val Tyr Gln Glu Ala Gly Leu Pro Ala Gly Val Leu Asn Val Val 
        195                 200                 205             

Phe Gly Asp Gly Pro Val Val Gly Glu Ala Met Leu His His Pro Gly 
    210                 215                 220                 

Ile Asp Val Ile Ser Phe Thr Gly Ser Thr Glu Thr Gly Arg His Ile 
225                 230                 235                 240 

Ala Ser Arg Ala Gly Ala Asn Leu Lys Arg Val Ser Leu Glu Met Gly 
                245                 250                 255     

Gly Lys Asn Ala Ile Thr Val Leu Ala Asp Ala Asp Leu Asp Leu Ala 
            260                 265                 270         

Val Asp Ala Ile Leu Trp Ser Ala Tyr Gly Thr Ser Gly Gln Arg Cys 
        275                 280                 285             

Thr Ala Ala Ser Arg Val Ile Val Glu Arg Glu Ala Glu Glu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Leu Leu Pro Arg Val Gln Ala Leu Arg Val Gly Asp Gly 
305                 310                 315                 320 

Leu Asp Pro Ala Val Asn Val Gly Pro Val Ile His Glu Glu Ala Leu 
                325                 330                 335     

Ala Lys Ile Asp Arg Tyr Val Arg Leu Gly Val Asp Glu Gly Ala Arg 
            340                 345                 350         

Leu Leu Thr Gly Gly Arg Arg Leu Thr Glu Gly Pro Leu Ala Arg Gly 
        355                 360                 365             

Phe Tyr Tyr Ala Pro Thr Val Phe Ala Gly Val Arg Pro Asp Met Arg 
    370                 375                 380                 

Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Cys Val Met Ala Val 
385                 390                 395                 400 

Asp Ser Phe Glu Glu Ala Ile Arg Val Asn Asn Gly Val Arg Tyr Gly 
                405                 410                 415     

Leu Ser Ala Ser Ile Phe Thr Arg Asp Val Asn Arg Val Phe Arg Ala 
            420                 425                 430         

Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Val Asn Ala Gly Thr Thr 
        435                 440                 445             

Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr Lys Ala Thr Gly Asn 
    450                 455                 460                 

Gly His Arg Asp Ser Gly Gln Ala Ala Leu Asp Val Phe Thr Glu Trp 
465                 470                 475                 480 

Lys Thr Val Tyr Val Asp Tyr Ser Gly Arg Leu Gln Arg Ala Gln Ile 
                485                 490                 495     

Asp Asn Asn 
            

<210>   1559
<211>   499
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1548

<400>   1559
Met Arg Arg Met His Arg Phe Glu Pro Cys Leu Asn Phe Ile Gly Gly 
                5                   10                  15      

Arg Trp Arg Glu Pro Lys Thr Gly Gln Tyr Gly Asp Asn Val Asn Pro 
            20                  25                  30          

Ala Asn Gly Glu Val Leu Gly Val Trp Ala Arg Ser Gly Pro Asp Asp 
        35                  40                  45              

Leu Asp Asp Ala Val Lys Ala Ala Arg Glu Ala Gln Ala Ala Trp Arg 
    50                  55                  60                  

Leu Val Pro Ala Pro Glu Arg Ala Lys Val Leu Arg Arg Val Ala Asp 
65                  70                  75                  80  

Leu Leu Arg Asp Arg Lys Asp Glu Ile Ala Arg Thr Leu Thr Met Glu 
                85                  90                  95      

Met Gly Lys Val Ile Glu Glu Ala Arg Gly Glu Val Gln Glu Ala Ile 
            100                 105                 110         

Asp Met Ala Glu Tyr Met Ala Gly Glu Gly Arg Arg Leu Phe Gly Gln 
        115                 120                 125             

Thr Thr Pro Ser Glu Leu Pro Asp Lys Phe Ala Met Ser Val Arg Val 
    130                 135                 140                 

Pro Val Gly Val Val Gly Ile Ile Thr Pro Trp Asn Phe Pro Ile Ala 
145                 150                 155                 160 

Ile Ala Ser Trp Lys Ser Leu Pro Ala Ile Val Ala Gly Asn Ala Val 
                165                 170                 175     

Val Trp Lys Pro Ala Glu Glu Thr Pro Leu Thr Ala Arg Ala Phe Val 
            180                 185                 190         

Glu Val Tyr Gln Glu Ala Gly Leu Pro Ala Gly Val Leu Asn Val Val 
        195                 200                 205             

Phe Gly Asp Gly Pro Val Val Gly Glu Ala Met Leu His His Pro Gly 
    210                 215                 220                 

Ile Asp Val Ile Ser Phe Thr Gly Ser Thr Glu Thr Gly Arg His Ile 
225                 230                 235                 240 

Ala Ser Arg Ala Gly Ala Asn Leu Lys Arg Val Ser Leu Glu Met Gly 
                245                 250                 255     

Gly Lys Asn Ala Ile Thr Val Leu Ala Asp Ala Asp Leu Asp Leu Ala 
            260                 265                 270         

Val Asp Ala Ile Leu Trp Ser Ala Tyr Gly Thr Ser Gly Gln Arg Cys 
        275                 280                 285             

Thr Ala Ala Ser Arg Val Ile Val Glu Arg Glu Ala Glu Glu Ala Leu 
    290                 295                 300                 

Leu Ala Arg Leu Leu Pro Arg Val Gln Ala Leu Arg Val Gly Asp Gly 
305                 310                 315                 320 

Leu Asp Pro Ala Val Asn Val Gly Pro Val Ile His Glu Glu Ala Leu 
                325                 330                 335     

Ala Lys Ile Asp Arg Tyr Val Arg Leu Gly Val Asp Glu Gly Ala Arg 
            340                 345                 350         

Leu Leu Thr Gly Gly Arg Arg Leu Thr Glu Gly Pro Leu Ala Arg Gly 
        355                 360                 365             

Phe Tyr Tyr Ala Pro Thr Val Phe Ala Gly Val Arg Pro Asp Met Arg 
    370                 375                 380                 

Ile Ala Gln Glu Glu Ile Phe Gly Pro Val Leu Cys Val Met Ala Val 
385                 390                 395                 400 

Asp Ser Phe Glu Glu Ala Ile Arg Val Asn Asn Gly Val Arg Tyr Gly 
                405                 410                 415     

Leu Ser Ala Ser Ile Phe Thr Arg Asp Val Asn Arg Val Phe Arg Ala 
            420                 425                 430         

Met Arg Asp Leu Asp Thr Gly Ile Val Tyr Val Asn Ala Gly Thr Thr 
        435                 440                 445             

Gly Ala Glu Ile His Leu Pro Phe Gly Gly Thr Lys Ala Thr Gly Asn 
    450                 455                 460                 

Gly His Arg Asp Ser Gly Gln Ala Ala Leu Asp Val Phe Thr Glu Trp 
465                 470                 475                 480 

Lys Thr Val Tyr Val Asp Tyr Ser Gly Arg Leu Gln Arg Ala Gln Ile 
                485                 490                 495     

Asp Asn Asn 
            

<210>   1560
<211>   1500
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1549

<400>   1560
gtgaggcgca tgcatcggtt tgagccttgt ctgaatttca tcggcggcag gtggcgcgag       60

cccaagacgg ggcagtacgg ggacaacgtc aaccccgcaa acggcgaggt gctcggggtg      120

tgggcgagat cgggcccgga cgatctcgac gacgccgtgc gggcggcccg cgaggcgcag      180

gccgcgtggc gcctggtgcc cgctccggag cgcgcgaagg tgctgcggcg cgtcgcggat      240

ctgctgcggg atcgcaagga cgagatcgcg cggacgctga caatggagat gggcaaggtc      300

atcgaggagg cgcgcggcga ggtgcaggag gccatcgaca tggccgagta catggcgggc      360

gaggggcgaa ggctgttcgg ccagacgacg ccctcggaac ttcccgacaa gttcgccatg      420

agcgtgcgcg ttccggtggg cgtggtgggg atcatcacgc cgtggaactt ccccatcgcc      480

atcgcgtcgt ggaagtcgct tccggccatc gtcgccggca acgccgtggt gtggaagccc      540

gcggaggaga caccgctcac cgcgcgggcg ttcgtggagg tgtatcagga ggccgggctg      600

cctgcgggcg ttctgaacgt ggtgttcggc gatggccccg tggtcggcga ggcgatgctc      660

catcaccccg ggatcgacgt catctccttc accggatcga cggagacggg gcggcacatc      720

gcgagccgtg cgggtgcgaa tctgaagcgc gtgtccctcg agatgggcgg caaaaacgcc      780

atcacggtgc tcgccgacgc ggacctggac ctcgccgtgg acgccatcct ctggagtgcc      840

tacggcacga gcggccagcg gtgcaccgcg gcgagccgcg tgatcgtgga gcgcgaggcg      900

gaggaagcgt tgctcgctcg cttgctgccg cgcgtgcagg cgctccgcgt cggcgacggg      960

ctggatccgg ccgtcaacgt cgggcccgtc atccacgagg aagccctcgc gaagatcgac     1020

cggtacgtgc ggattggcgt ggacgagggt gcgcggctct tgactggcgg ccgcaggctg     1080

acggagggcc cgctggcgcg cggcttttac tatgcgccga ccgtgttcgc cggcgtccgc     1140

cccgacatgc gcatcgcgca ggaggagatc ttcggcccgg tgctctgcgt gatggccgtc     1200

gactcgttcg aggaagccat ccgcgtcaac aacggggttc gctacgggct ctcggccagc     1260

atcttcacgc gcgacgtcaa ccgcgtgttt cgcgccatgc gcgatctcga caccgggatc     1320

gtgtacgtca acgcgggcac gacgggcgcc gaaattcacc tgccgttcgg cggtaccaag     1380

gccaccggaa acgggcaccg agattccggc caggccgcct tggacgtctt cacggagtgg     1440

aagaccgtgt acgtcgatta cagcggccgg ctgcagcgcg cgcagatcga caacaactga     1500


<210>   1561
<211>   1500
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1549

<400>   1561
gtgaggcgca tgcatcggtt tgagccttgt ctgaatttca tcggcggcag gtggcgcgag       60

cccaagacgg ggcagtacgg ggacaacgtc aaccccgcaa acggcgaggt gctcggggtg      120

tgggcgagat cgggcccgga cgatctcgac gacgccgtgc gggcggcccg cgaggcgcag      180

gccgcgtggc gcctggtgcc cgctccggag cgcgcgaagg tgctgcggcg cgtcgcggat      240

ctgctgcggg atcgcaagga cgagatcgcg cggacgctga caatggagat gggcaaggtc      300

atcgaggagg cgcgcggcga ggtgcaggag gccatcgaca tggccgagta catggcgggc      360

gaggggcgaa ggattttcgg ccagacgacg ccctcggaac ttcccgacaa gttcgccatg      420

agcgtgcgcg ttccggtggg cgtggtgggg atcatcacgc cgtggaactt ccccatcgcc      480

atcgcgtcgt ggaagtcgct tccggccatc gtcgccggca acgccgtggt gtggaagccc      540

gcggaggaga caccgctcac cgcgcgggcg ttcgtggagg tgtatcagga ggccgggctg      600

cctgcgggcg ttctgaacgt ggtgttcggc gatggccccg tggtcggcga ggcgatgctc      660

catcaccccg ggatcgacgt catctccttc accggatcga cggagacggg gcggcacatc      720

gcgagccgtg cgggtgcgaa tctgaagcgc gtgtccctcg agatgggcgg caaaaacgcc      780

atcacggtgc tcgccgacgc ggacctggac ctcgccgtgg acgccatcct ctggagtgcc      840

tacggcacga gcggccagcg gtgcaccgcg gcgagccgcg tgatcgtgga gcgcgaggcg      900

gaggaagcgt tgctcgctcg cttgctgccg cgcgtgcagg cgctccgcgt cggcgacggg      960

ctggatccgg ccgtcaacgt cgggcccgtc atccacgagg aagccctcgc gaagatcgac     1020

cggtacgtgc ggctcggcgt ggacgagggt gcgcggctct tgactggcgg ccgcaggctg     1080

acggagggcc cgctggcgcg cggcttttac tatgcgccga ccgtgttcgc cggcgtccgc     1140

cccgacatgc gcatcgcgca ggaggagatc ttcggcccgg tgctctgcgt gatggccgtc     1200

gactcgttcg aggaagccat ccgcgtcaac aacggggttc gctacgggct ctcggccagc     1260

atcttcacgc gcgacgtcaa ccgcgtgttt cgcgccatgc gcgatctcga caccgggatc     1320

gtgtacgtca acgcgggcac gacgggcgcc gaaattcacc tgccgttcgg cggtaccaag     1380

gccaccggaa acgggcaccg agattccggc caggccgcct tggacgtctt cacggagtgg     1440

aagaccgtgt acgtcgatta cagcggccgg ctgcagcgcg cgcagatcga caacaactga     1500


<210>   1562
<211>   1500
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1549

<400>   1562
gtgaggcgca tgcatcggtt tgagccttgt ctgaatttca tcggcggcag gtggcgcgag       60

cccaagacgg ggcagtacgg ggacaacgtc aaccccgcaa acggcgaggt gctcggggtg      120

tgggcgagat cgggcccgga cgatctcgac gacgccgtgc gggcggcccg cgaggcgcag      180

gccgcgtgga aactggtgcc cgctccggag cgcgcgaagg tgctgcggcg cgtcgcggat      240

ctgctgcggg atcgcaagga cgagatcgcg cggacgctga caatggagat gggcaaggtc      300

atcgaggagg cgcgcggcga ggtgcaggag gccatcgaca tggccgagta catggcgggc      360

gaggggcgaa ggctgttcgg ccagacgacg ccctcggaac ttcccgacaa gttcgccatg      420

agcgtgcgcg ttccggtggg cgtggtgggg atcatcacgc cgtggaactt ccccatcgcc      480

atcgcgtcgt ggaagtcgct tccggccatc gtcgccggca acgccgtggt gtggaagccc      540

gcggaggaga caccgctcac cgcgcgggcg ttcgtggagg tgtatcagga ggccgggctg      600

cctgcgggcg ttctgaacgt ggtgttcggc gatggccccg tggtcggcga ggcgatgctc      660

catcaccccg ggatcgacgt catctccttc accggatcga cggagacggg gcggcacatc      720

gcgagccgtg cgggtgcgaa tctgaagcgc gtgtccctcg agatgggcgg caaaaacgcc      780

atcacggtgc tcgccgacgc ggacctggac ctcgccgtgg acgccatcct ctggagtgcc      840

tacggcacga gcggccagcg gtgcaccgcg gcgagccgcg tgatcgtgga gcgcgaggcg      900

gaggaagcgt tgctcgctcg cttgctgccg cgcgtgcagg cgctccgcgt cggcgacggg      960

ctggatccgg ccgtcaacgt cgggcccgtc atccacgagg aagccctcgc gaagatcgac     1020

cggtacgtgc ggctcggcgt ggacgagggt gcgcggctct tgactggcgg ccgcaggctg     1080

acggagggcc cgctggcgcg cggcttttac tatgcgccga ccgtgttcgc cggcgtccgc     1140

cccgacatgc gcatcgcgca ggaggagatc ttcggcccgg tgctctgcgt gatggccgtc     1200

gactcgttcg aggaagccat ccgcgtcaac aacggggttc gctacgggct ctcggccagc     1260

atcttcacgc gcgacgtcaa ccgcgtgttt cgcgccatgc gcgatctcga caccgggatc     1320

gtgtacgtca acgcgggcac gacgggcgcc gaaattcacc tgccgttcgg cggtaccaag     1380

gccaccggaa acgggcaccg agattccggc caggccgcct tggacgtctt cacggagtgg     1440

aagaccgtgt acgtcgatta cagcggccgg ctgcagcgcg cgcagatcga caacaactga     1500


<210>   1563
<211>   1500
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1549

<400>   1563
gtgaggcgca tgcatcggtt tgatccttgt ctgaatttca tcggcggcag gtggcgcgag       60

cccaagacgg ggcagtacgg ggacaacgtc aaccccgcaa acggcgaggt gctcggggtg      120

tgggcgagat cgggcccgga cgatctcgac gacgccgtgc gggcggcccg cgaggcgcag      180

gccgcgtggc gcctggtgcc cgctccggag cgcgcgaagg tgctgcggcg cgtcgcggat      240

ctgctgcggg atcgcaagga cgagatcgcg cggacgctga caatggagat gggcaaggtc      300

atcgaggagg cgcgcggcga ggtgcaggag gccatcgaca tggccgagta catggcgggc      360

gaggggcgaa ggctgttcgg ccagacgacg ccctcggaac ttcccgacaa gttcgccatg      420

agcgtgcgcg ttccggtggg cgtggtgggg atcatcacgc cgtggaactt ccccatcgcc      480

atcgcgtcgt ggaagtcgct tccggccatc gtcgccggca acgccgtggt gtggaagccc      540

gcggaggaga caccgctcac cgcgcgggcg ttcgtggagg tgtatcagga ggccgggctg      600

cctgcgggcg ttctgaacgt ggtgttcggc gatggccccg tggtcggcga ggcgatgctc      660

catcaccccg ggatcgacgt catctccttc accggatcga cggagacggg gcggcacatc      720

gcgagccgtg cgggtgcgaa tctgaagcgc gtgtccctcg agatgggcgg caaaaacgcc      780

atcacggtgc tcgccgacgc ggacctggac ctcgccgtgg acgccatcct ctggagtgcc      840

tacggcacga gcggccagcg gtgcaccgcg gcgagccgcg tgatcgtgga gcgcgaggcg      900

gaggaagcgt tgctcgctcg cttgctgccg cgcgtgcagg cgctccgcgt cggcgacggg      960

ctggatccgg ccgtcaacgt cgggcccgtc atccacgagg aagccctcgc gaagatcgac     1020

cggtacgtgc ggctcggcgt ggacgagggt gcgcggctct tgactggcgg ccgcaggctg     1080

acggagggcc cgctggcgcg cggcttttac tatgcgccga ccgtgttcgc cggcgtccgc     1140

cccgacatgc gcatcgcgca ggaggagatc ttcggcccgg tgctctgcgt gatggccgtc     1200

gactcgttcg aggaagccat ccgcgtcaac aacggggttc gctacgggct ctcggccagc     1260

atcttcacgc gcgacgtcaa ccgcgtgttt cgcgccatgc gcgatctcga caccgggatc     1320

gtgtacgtca acgcgggcac gacgggcgcc gaaattcacc tgccgttcgg cggtaccaag     1380

gccaccggaa acgggcaccg agattccggc caggccgcct tggacgtctt cacggagtgg     1440

aagaccgtgt acgtcgatta cagcggccgg ctgcagcgcg cgcagatcga caacaactga     1500


<210>   1564
<211>   1500
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1549

<400>   1564
gtgaggcgca tgcatcggtt tgagccttgt ctgaatttca tcggcggcag gtggcgcgag       60

cccaagacgg ggcagtacgg ggacaacgtc aaccccgcaa acggcgaggt gctcggggtg      120

tgggcgagat cgggcccgga cgatctcgac gacgccgtga aagcggcccg cgaggcgcag      180

gccgcgtggc gcctggtgcc cgctccggag cgcgcgaagg tgctgcggcg cgtcgcggat      240

ctgctgcggg atcgcaagga cgagatcgcg cggacgctga caatggagat gggcaaggtc      300

atcgaggagg cgcgcggcga ggtgcaggag gccatcgaca tggccgagta catggcgggc      360

gaggggcgaa ggctgttcgg ccagacgacg ccctcggaac ttcccgacaa gttcgccatg      420

agcgtgcgcg ttccggtggg cgtggtgggg atcatcacgc cgtggaactt ccccatcgcc      480

atcgcgtcgt ggaagtcgct tccggccatc gtcgccggca acgccgtggt gtggaagccc      540

gcggaggaga caccgctcac cgcgcgggcg ttcgtggagg tgtatcagga ggccgggctg      600

cctgcgggcg ttctgaacgt ggtgttcggc gatggccccg tggtcggcga ggcgatgctc      660

catcaccccg ggatcgacgt catctccttc accggatcga cggagacggg gcggcacatc      720

gcgagccgtg cgggtgcgaa tctgaagcgc gtgtccctcg agatgggcgg caaaaacgcc      780

atcacggtgc tcgccgacgc ggacctggac ctcgccgtgg acgccatcct ctggagtgcc      840

tacggcacga gcggccagcg gtgcaccgcg gcgagccgcg tgatcgtgga gcgcgaggcg      900

gaggaagcgt tgctcgctcg cttgctgccg cgcgtgcagg cgctccgcgt cggcgacggg      960

ctggatccgg ccgtcaacgt cgggcccgtc atccacgagg aagccctcgc gaagatcgac     1020

cggtacgtgc ggctcggcgt ggacgagggt gcgcggctct tgactggcgg ccgcaggctg     1080

acggagggcc cgctggcgcg cggcttttac tatgcgccga ccgtgttcgc cggcgtccgc     1140

cccgacatgc gcatcgcgca ggaggagatc ttcggcccgg tgctctgcgt gatggccgtc     1200

gactcgttcg aggaagccat ccgcgtcaac aacggggttc gctacgggct ctcggccagc     1260

atcttcacgc gcgacgtcaa ccgcgtgttt cgcgccatgc gcgatctcga caccgggatc     1320

gtgtacgtca acgcgggcac gacgggcgcc gaaattcacc tgccgttcgg cggtaccaag     1380

gccaccggaa acgggcaccg agattccggc caggccgcct tggacgtctt cacggagtgg     1440

aagaccgtgt acgtcgatta cagcggccgg ctgcagcgcg cgcagatcga caacaactga     1500


<210>   1565
<211>   341
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1565
Met Val Ala Gly Arg Asp Gly Gly His Gly Leu Gly Thr Gln Arg Ser 
                5                   10                  15      

Arg Arg Thr Val Arg Asp Asp Gly Arg Ala Cys Gly Trp Val Tyr Gln 
            20                  25                  30          

Met Arg Leu Arg Gly Gly Arg Val Met Gly Ala Glu Lys Asp Val Tyr 
        35                  40                  45              

Ser Arg Leu Arg Gly Ser Ile Val Pro Met Val Thr Pro Phe Leu Glu 
    50                  55                  60                  

Asp Gly Ser Phe Asp Glu Lys Ser Tyr Arg Glu Leu Ile Glu Trp Gln 
65                  70                  75                  80  

Ile Glu Ser Gly Ser His Gly Ile Ser Cys Ala Gly Thr Thr Gly Glu 
                85                  90                  95      

Pro Ser Ser Leu Thr Ile Glu Glu Arg Glu Tyr Leu Phe Glu Val Thr 
            100                 105                 110         

Met Asp Ala Val Arg Gly Arg Val Pro Val Val Leu Gly Thr Gly Ser 
        115                 120                 125             

Thr Asn His Ala Glu Ala Leu Arg Leu Thr Lys Thr Ala Glu Arg Leu 
    130                 135                 140                 

Gly Ala Asp Ala Ala Leu Val Ile Val Pro Tyr Tyr Asn Arg Pro Ser 
145                 150                 155                 160 

Gln Glu Gly Leu Tyr Arg His Phe Arg Ala Ile Ala Asp Ser Val Asp 
                165                 170                 175     

Ile Pro Ile Ile Leu Tyr Asn Ile Pro Gly Arg Thr Gly Val Asn Leu 
            180                 185                 190         

Glu Pro Ala Thr Met Ala Arg Leu Lys Arg Asp Cys Arg Asn Ile Ile 
        195                 200                 205             

Gly Val Lys Glu Ser Asn Lys Asp Phe Glu Gln Val Thr Arg Val Phe 
    210                 215                 220                 

Gln Ala Cys Gly Arg Asp Phe Leu Val Tyr Ser Gly Ile Glu Leu Leu 
225                 230                 235                 240 

Cys Tyr Pro Met Leu Ala Leu Gly Gly Ala Gly His Leu Ser Ala Thr 
                245                 250                 255     

Ala Asn Leu Met Pro Arg Glu Val Ala Arg Leu Tyr Asp Leu Val Gln 
            260                 265                 270         

Ala Gly Lys Trp His Glu Ala Ile Asp Leu His Phe Gln Leu Val Asp 
        275                 280                 285             

Ile Asn Glu Ala Leu Phe Trp Glu Thr Asn Pro Gly Pro Val Lys Ala 
    290                 295                 300                 

Cys Leu Ala Met Met Gly Lys Ile Arg Pro Val Val Arg Pro Pro Leu 
305                 310                 315                 320 

Ala Leu Pro Gly Glu Glu Met Thr Ala Lys Leu Arg Gly Val Leu Thr 
                325                 330                 335     

Ser Tyr Gly Leu Ile 
            340     

<210>   1566
<211>   1026
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   1566
ttggtggcgg gacgggacgg tggtcatgga ttgggaacgc aacgttcccg tcgaactgtg       60

cgggacgacg gacgcgcgtg cggctgggta tatcaaatga gactgcgagg gggacgggtc      120

atgggcgccg aaaaggacgt gtattcgcgc cttcggggat ccatcgtgcc gatggtcacg      180

ccgtttttgg aggacggatc gtttgacgag aagtcgtatc gtgaactcat tgagtggcag      240

atcgagagcg gttctcacgg tatctcttgc gcaggaacaa ctggagaacc gagttccctt      300

acgatagaag aacgagaata cttattcgaa gtcacgatgg atgccgtgcg cggtcgggtg      360

cctgtggtgt tggggacggg ctcgacgaac cacgcggagg cgcttcggct cacgaagacg      420

gctgaacggc tgggtgcgga tgccgcgctg gtcatcgttc cgtattacaa ccgtccgtcc      480

caggaggggc tctaccggca ctttcgcgcg atagcggaca gcgtcgacat tcccatcatc      540

ctgtacaaca ttccgggacg caccggggtg aacctagagc ccgccacgat ggcccggctc      600

aagcgcgact gccgtaacat cattggcgtc aaggaatcga acaaggactt tgagcaggtt      660

acacgcgtgt tccaggcctg cggccgcgat ttcctggtct attccggcat agagctcctg      720

tgttacccca tgctcgcgct gggaggagcg gggcatctca gcgcgaccgc caatctcatg      780

ccgagagaag tcgcccgcct gtacgacttg gtgcaagccg ggaagtggca tgaagcgatc      840

gatcttcact ttcaactggt cgacatcaat gaggctttgt tctgggagac gaacccaggt      900

ccggtcaagg cgtgccttgc catgatgggc aaaattcggc ccgtggtgag gccgccgctc      960

gcgctgccag gagaggaaat gacggcaaag ctgcgaggcg tgctgacttc gtatgggctg     1020

atctga                                                                1026


<210>   1567
<211>   299
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   1567
Ala Tyr Arg Glu Val Lys Glu Arg Leu Arg Gly Ser Ile Ala Pro Val 
                5                   10                  15      

Val Thr Pro Phe Asp Glu Glu Gly Asn Val Asp Leu Thr Thr Leu Thr 
            20                  25                  30          

Ser Leu Ile Asp Trp His Ile Lys Ser Gly Thr His Gly Ile Ser Val 
        35                  40                  45              

Thr Gly Thr Ser Gly Glu Pro Ser Ser Leu Thr Leu Asp Glu Arg Lys 
    50                  55                  60                  

Gln Val Met Glu Thr Ala Lys Lys Ala Val Ala Gly Arg Val Pro Phe 
65                  70                  75                  80  

Val Pro Gly Thr Gly Ser Thr Asn His Ala Glu Thr Ile Glu Leu Thr 
                85                  90                  95      

Lys Phe Ala Gln Glu Ile Gly Ala Asp Ala Ala Met Val Ile Val Pro 
            100                 105                 110         

Tyr Tyr Asn Arg Pro Ser Gln Gln Ala Leu Tyr Lys His Phe Lys Ala 
        115                 120                 125             

Val Ala Glu Ser Val Asp Ile Pro Ile Ile Val Tyr Asn Ile Pro Gly 
    130                 135                 140                 

Arg Thr Ala Val Asn Leu Glu Val Lys Thr Leu Ala Arg Leu Val Glu 
145                 150                 155                 160 

Asp Cys Pro Asn Ile Ile Gly Val Lys Glu Ser Asn Lys Asp Phe Glu 
                165                 170                 175     

His Val Asn Arg Val Leu Trp His Cys Gly Arg Asp Phe Leu Leu Phe 
            180                 185                 190         

Ser Gly Ile Glu Leu Leu Cys Tyr Pro Met Leu Ala Ile Gly Gly Ala 
        195                 200                 205             

Gly Ser Ile Ser Ala Thr Ala Asn Val Val Pro Gln Lys Val Ala Glu 
    210                 215                 220                 

Leu His Asp Ala Trp Phe Asp Gly Asp Val Lys Arg Ala Gln Asp Leu 
225                 230                 235                 240 

His Phe Glu Leu Met Glu Leu Asn Asp Val Leu Phe Ile Glu Thr Asn 
                245                 250                 255     

Pro Gly Pro Val Lys Ala Ala Leu Gly Met Leu Gly Lys Ile Thr Pro 
            260                 265                 270         

Lys Leu Arg Leu Pro Leu Asp Leu Pro Ser Glu Glu His Gln Glu Gln 
        275                 280                 285             

Ile Arg Arg Thr Leu Val Lys Tyr Gly Leu Leu 
    290                 295                 

<210>   1568
<211>   299
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   1568
Ala Tyr His Glu Ala Lys Glu Arg Leu Arg Gly Ser Ile Ala Pro Val 
                5                   10                  15      

Val Thr Pro Phe Asp Glu Glu Gly Asn Val Asp Phe Ala Ala Leu Ala 
            20                  25                  30          

Ala Leu Ile Asp Trp His Ile Glu Ser Gly Thr His Gly Ile Ser Val 
        35                  40                  45              

Thr Gly Thr Ser Gly Glu Pro Ser Ser Leu Thr Leu Glu Glu Arg Lys 
    50                  55                  60                  

Gln Val Met Glu Thr Ala Lys Lys Ala Val Ala Gly Arg Val Pro Phe 
65                  70                  75                  80  

Val Pro Gly Thr Gly Ser Thr Asn His Ala Glu Thr Ile Glu Leu Thr 
                85                  90                  95      

Lys Phe Ala Gln Glu Ile Gly Ala Asp Ala Ala Met Val Ile Val Pro 
            100                 105                 110         

Tyr Tyr Asn Arg Pro Ser Gln Gln Ala Leu Tyr Lys His Phe Lys Ala 
        115                 120                 125             

Val Ala Glu Ala Val Asp Ile Pro Ile Ile Val Tyr Asn Ile Pro Gly 
    130                 135                 140                 

Arg Thr Ala Val Asn Leu Glu Val Lys Thr Leu Ala Arg Leu Ala Glu 
145                 150                 155                 160 

Asp Cys Pro Asn Ile Ile Gly Val Lys Glu Ser Asn Lys Asp Phe Glu 
                165                 170                 175     

His Val Asn Arg Val Leu Trp His Cys Gly Arg Asp Phe Leu Leu Phe 
            180                 185                 190         

Ser Gly Ile Glu Leu Leu Cys Tyr Pro Met Leu Ala Ile Gly Gly Ala 
        195                 200                 205             

Gly Ser Ile Ser Ala Thr Ala Asn Val Val Pro His Lys Val Ala Glu 
    210                 215                 220                 

Leu His Asp Ala Trp Phe Glu Gly Asp Ile Lys Arg Ala Gln Asp Leu 
225                 230                 235                 240 

His Phe Glu Leu Met Glu Leu Asn Asp Val Leu Phe Ile Glu Thr Asn 
                245                 250                 255     

Pro Gly Pro Val Lys Ala Ala Leu Gly Met Met Gly Lys Ile Thr Pro 
            260                 265                 270         

Lys Leu Arg Leu Pro Leu Asp Leu Pro Ser Glu Glu His Gln Gln Gln 
        275                 280                 285             

Ile Arg Arg Thr Leu Val Lys Tyr Gly Leu Leu 
    290                 295                 

<210>   1569
<211>   289
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   1569
Lys Leu Arg Gly Ser Ile Ala Pro Ile Ile Thr Pro Phe Asp Glu Ser 
                5                   10                  15      

Gly Ala Ile Asp Phe Gln Thr Phe Glu Asn Leu Ile His Trp His Ile 
            20                  25                  30          

Glu Ser Gly Ser His Gly Ile Ser Val Thr Gly Thr Thr Gly Glu Pro 
        35                  40                  45              

Ser Ser Leu Lys Val Glu Glu Arg Val Lys Val Met Glu Thr Ala Ala 
    50                  55                  60                  

Lys Ala Ile Asn Gly Arg Val Pro Phe Ala Pro Gly Thr Gly Ser Thr 
65                  70                  75                  80  

Asn His Glu Glu Thr Leu Tyr Leu Thr Lys Lys Ala Gln Glu Ile Gly 
                85                  90                  95      

Ala Asp Ala Ala Leu Val Ile Val Pro Tyr Tyr Asn Lys Pro Ser Gln 
            100                 105                 110         

His Ala Leu Tyr Lys His Phe Lys Thr Val Ala Asp Ser Val Asp Ile 
        115                 120                 125             

Pro Ile Ile Ile Tyr Asn Ile Pro Gly Arg Thr Ala Val Asn Leu Gln 
    130                 135                 140                 

Val Glu Thr Ile Ala Lys Leu Asn Gln Asp Cys Pro Asn Ile Ile Gly 
145                 150                 155                 160 

Ile Lys Glu Ser Asn Lys Asp Phe Glu His Ile Asn Arg Val Leu Leu 
                165                 170                 175     

His Cys Gly Arg Asp Phe Leu Leu Phe Ser Gly Ile Glu Leu Leu Cys 
            180                 185                 190         

Tyr Pro Met Leu Ala Ile Gly Gly Ala Gly His Ile Ser Ala Thr Ala 
        195                 200                 205             

Asn Val Ala Pro Lys Gln Val Ala Glu Val Tyr Asn Ala Trp Asn Glu 
    210                 215                 220                 

Gly Asp Ile Lys Arg Ala Leu Thr Leu His Tyr Glu Leu Met Pro Leu 
225                 230                 235                 240 

Asn Asp Val Leu Phe Lys Asp Thr Asn Pro Ala Pro Val Lys Ala Ala 
                245                 250                 255     

Leu Gly Met Met Gly Lys Ile Lys Pro Val Leu Arg Leu Pro Met Asp 
            260                 265                 270         

Val Pro Ser Gln Glu Leu Gln Asp Glu Ile Arg Asp Val Leu Lys Asn 
        275                 280                 285             

Tyr 
    

<210>   1570
<211>   295
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   1570
Ile Lys Lys Arg Leu Arg Gly Ser Ile Ala Pro Val Ile Thr Pro Phe 
                5                   10                  15      

Lys Val Asn Gly Asp Ile Asp Phe Lys Lys Gln Ser Glu Leu Ile Glu 
            20                  25                  30          

Phe Gln Ile Glu Asn Gly Thr His Ala Ile Ser Val Thr Gly Thr Ser 
        35                  40                  45              

Gly Glu Pro Ser Ser Leu Thr Thr Glu Glu Arg Val Gln Val Met Glu 
    50                  55                  60                  

Asn Ala Ile Lys Thr Ile Asn Gly Arg Ile Pro Phe Ala Pro Gly Thr 
65                  70                  75                  80  

Gly Ser Thr Asn His Asp Glu Thr Met Tyr Val Thr Lys Lys Ala Glu 
                85                  90                  95      

Glu Met Gly Ala Asp Ala Ala Met Val Ile Val Pro Tyr Tyr Asn Lys 
            100                 105                 110         

Pro Asn Gln Glu Ala Leu Tyr Asp His Phe Lys Thr Val Ala Asp Ser 
        115                 120                 125             

Val Asp Ile Pro Ile Ile Ile Tyr Asn Ile Pro Gly Arg Thr Ala Gln 
    130                 135                 140                 

Asn Met Glu Val Lys Thr Met Ala Arg Leu Val Lys Asp Cys Pro Asn 
145                 150                 155                 160 

Ile Val Gly Ala Lys Glu Ser Asn Lys Asp Phe Glu His Val Asn Arg 
                165                 170                 175     

Val Leu Leu Asn Cys Gly Arg Asp Phe Leu Leu Phe Ser Gly Ile Glu 
            180                 185                 190         

Leu Leu Cys Tyr Pro Met Leu Ala Ile Gly Gly Ala Gly Ser Ile Ser 
        195                 200                 205             

Ala Thr Ala Asn Val Glu Pro Lys Lys Val Ala Glu Met His Asn Ala 
    210                 215                 220                 

Trp Glu Glu Gly Asp Ile Lys Arg Ala Gln Asp Leu His Phe Glu Leu 
225                 230                 235                 240 

Met Asn Leu Asn Asp Val Leu Phe Lys Asp Thr Asn Pro Ala Pro Val 
                245                 250                 255     

Lys Ala Ala Leu Gly Met Met Gly Met Ile Glu Pro Val Leu Arg Arg 
            260                 265                 270         

Pro Met Gly Leu Pro Ser Asp Ala Leu Gln Glu Glu Ile Arg Asp Thr 
        275                 280                 285             

Leu Val Lys Tyr Gly Lys Ile 
    290                 295 

<210>   1571
<211>   290
<212>   PRT
<213>   Thermus thermophilus HB8

<400>   1571
Arg Gly Ser Ile Pro Pro Leu Pro Thr Pro Phe Arg Arg Gly Arg Leu 
                5                   10                  15      

Asp Glu Glu Ala Leu Arg Arg Leu Val Glu Arg Val Val Gln Gly Gly 
            20                  25                  30          

Ser His Gly Val Ser Val Gly Gly Thr Thr Gly Glu Pro Gly Thr Gln 
        35                  40                  45              

Thr Leu Glu Glu Arg Lys Arg Ala Ile Glu Val Val Leu Asp Gln Val 
    50                  55                  60                  

Ala Gly Arg Val Pro Val Ile Pro Gly Thr Gly Ala Leu Arg Leu Glu 
65                  70                  75                  80  

Glu Thr Leu Glu Leu Thr Arg Phe Ala Lys Glu Ala Gly Ala Gln Gly 
                85                  90                  95      

Ala Met Val Ile Val Pro Tyr Tyr Val Lys Pro Asn Gln Glu Gly Leu 
            100                 105                 110         

Tyr Arg Tyr Phe Ala Glu Val Ala Arg Thr Val Pro Asp Phe Pro Leu 
        115                 120                 125             

Leu Ile Tyr Asn Ile Pro Gly Arg Ala Gly Val Glu Ile Ala Pro Lys 
    130                 135                 140                 

Thr Val Gly Arg Leu Arg Arg Asp Phe Pro Asn Ile Val Gly Leu Lys 
145                 150                 155                 160 

His Ser Ser Lys Asp Leu Glu Tyr Leu Ser His Leu Phe Leu Glu Ala 
                165                 170                 175     

Gly Arg Asp Phe Leu Val Phe Cys Gly Leu Glu Ser Leu Thr Leu Pro 
            180                 185                 190         

Met Met Ser Leu Gly Ala Val Gly Thr Ile Ala Ala Thr Ala Asn Trp 
        195                 200                 205             

Leu Pro Lys Glu Val Ala Leu Leu Cys Glu Lys Ala Leu Ala Gly Asp 
    210                 215                 220                 

Tyr Gln Gly Ala Arg Glu Leu His Phe His Leu Leu Glu Ala Asn Glu 
225                 230                 235                 240 

Ala Ile Phe Trp Asp Thr Asn Pro Ile Pro Leu Lys Thr Val Leu Ser 
                245                 250                 255     

Trp Met Gly Leu Leu Glu Lys Glu Trp Arg Pro Pro Leu Gly Pro Thr 
            260                 265                 270         

Thr Pro Glu Val Glu Glu Arg Leu Arg Arg Met Ala Glu Arg Tyr Gly 
        275                 280                 285             

Leu Leu 
    290 

<210>   1572
<211>   341
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1565

<400>   1572
Met Val Ala Gly Arg Asp Gly Gly His Gly Leu Gly Thr Gln Arg Ser 
                5                   10                  15      

Arg Arg Thr Ile Arg Asp Asp Gly Arg Ala Cys Gly Trp Val Tyr Gln 
            20                  25                  30          

Met Arg Leu Arg Gly Gly Arg Val Met Gly Ala Glu Lys Asp Val Tyr 
        35                  40                  45              

Ser Arg Leu Arg Gly Ser Ile Val Pro Met Val Thr Pro Phe Leu Glu 
    50                  55                  60                  

Asp Gly Ser Phe Asp Glu Lys Ser Tyr Arg Glu Leu Ile Glu Trp Gln 
65                  70                  75                  80  

Ile Glu Ser Gly Ser His Gly Ile Ser Cys Ala Gly Thr Thr Gly Glu 
                85                  90                  95      

Pro Ser Ser Leu Thr Ile Glu Glu Arg Glu Tyr Leu Phe Glu Val Thr 
            100                 105                 110         

Met Asp Ala Val Arg Gly Arg Val Pro Val Val Leu Gly Thr Gly Ser 
        115                 120                 125             

Thr Asn His Ala Glu Ala Leu Arg Leu Thr Lys Thr Ala Glu Arg Leu 
    130                 135                 140                 

Gly Ala Asp Ala Ala Leu Val Ile Val Pro Tyr Tyr Asn Arg Pro Ser 
145                 150                 155                 160 

Gln Glu Gly Leu Tyr Arg His Phe Arg Ala Ile Ala Asp Ser Val Asp 
                165                 170                 175     

Ile Pro Ile Ile Leu Tyr Asn Ile Pro Gly Arg Thr Gly Val Asn Leu 
            180                 185                 190         

Glu Pro Ala Thr Met Ala Arg Leu Lys Arg Asp Cys Arg Asn Ile Ile 
        195                 200                 205             

Gly Val Lys Glu Ser Asn Lys Asp Phe Glu Gln Val Thr Arg Val Phe 
    210                 215                 220                 

Gln Ala Cys Gly Arg Asp Phe Leu Val Tyr Ser Gly Ile Glu Leu Leu 
225                 230                 235                 240 

Cys Tyr Pro Met Leu Ala Leu Gly Gly Ala Gly His Leu Ser Ala Thr 
                245                 250                 255     

Ala Asn Leu Met Pro Arg Glu Val Ala Arg Leu Tyr Asp Leu Val Gln 
            260                 265                 270         

Ala Gly Lys Trp His Glu Ala Ile Asp Leu His Phe Gln Leu Val Asp 
        275                 280                 285             

Ile Asn Glu Ala Leu Phe Trp Glu Thr Asn Pro Gly Pro Val Lys Ala 
    290                 295                 300                 

Cys Leu Ala Met Met Gly Lys Ile Arg Pro Val Val Arg Pro Pro Leu 
305                 310                 315                 320 

Ala Leu Pro Gly Glu Glu Met Thr Ala Lys Leu Arg Gly Val Leu Thr 
                325                 330                 335     

Ser Tyr Gly Leu Ile 
            340     

<210>   1573
<211>   341
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1565

<400>   1573
Met Val Ala Gly Arg Asp Gly Gly His Gly Leu Gly Thr Gln Arg Ser 
                5                   10                  15      

Arg Arg Thr Val Arg Asp Asp Gly Arg Ala Cys Gly Trp Val Tyr Gln 
            20                  25                  30          

Met Arg Leu Arg Gly Gly Arg Val Met Gly Ala Glu Lys Asp Val Tyr 
        35                  40                  45              

Ser Arg Leu Arg Gly Ser Ile Val Pro Met Val Thr Pro Phe Leu Glu 
    50                  55                  60                  

Asp Gly Ser Phe Asp Glu Lys Ser Tyr Arg Glu Leu Ile Glu Trp Gln 
65                  70                  75                  80  

Ile Glu Ser Gly Ser His Gly Ile Ser Cys Ala Gly Thr Thr Gly Glu 
                85                  90                  95      

Pro Ser Ser Leu Thr Ile Glu Glu Arg Glu Tyr Leu Phe Glu Val Thr 
            100                 105                 110         

Met Asp Ala Val Arg Gly Arg Val Pro Val Val Leu Gly Thr Gly Ser 
        115                 120                 125             

Thr Asn His Ala Glu Ala Leu Arg Leu Thr Lys Thr Ala Glu Arg Leu 
    130                 135                 140                 

Gly Ala Asp Ala Ala Leu Val Ile Val Pro Tyr Tyr Asn Arg Pro Ser 
145                 150                 155                 160 

Gln Glu Gly Leu Tyr Arg His Phe Arg Ala Ile Ala Asp Ser Val Asp 
                165                 170                 175     

Ile Pro Ile Ile Leu Tyr Asn Ile Pro Gly Arg Thr Gly Val Asn Leu 
            180                 185                 190         

Glu Pro Ala Thr Met Ala Arg Leu Lys Arg Asp Cys Arg Asn Ile Ile 
        195                 200                 205             

Gly Val Lys Glu Ser Asn Lys Asp Phe Glu Gln Val Thr Arg Val Phe 
    210                 215                 220                 

Gln Ala Cys Gly Arg Asp Phe Leu Val Tyr Ser Gly Ile Glu Leu Leu 
225                 230                 235                 240 

Cys Tyr Pro Met Leu Ala Leu Gly Gly Ala Gly His Leu Ser Ala Thr 
                245                 250                 255     

Ala Asn Leu Met Pro Arg Glu Val Ala Arg Leu Tyr Asp Ile Val Gln 
            260                 265                 270         

Ala Gly Lys Trp His Glu Ala Ile Asp Leu His Phe Gln Leu Val Asp 
        275                 280                 285             

Ile Asn Glu Ala Leu Phe Trp Glu Thr Asn Pro Gly Pro Val Lys Ala 
    290                 295                 300                 

Cys Leu Ala Met Met Gly Lys Ile Arg Pro Val Val Arg Pro Pro Leu 
305                 310                 315                 320 

Ala Leu Pro Gly Glu Glu Met Thr Ala Lys Leu Arg Gly Val Leu Thr 
                325                 330                 335     

Ser Tyr Gly Leu Ile 
            340     

<210>   1574
<211>   341
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1565

<400>   1574
Met Val Ala Gly Arg Asp Gly Gly His Gly Leu Gly Thr Gln Arg Ser 
                5                   10                  15      

Arg Arg Thr Val Arg Asp Asp Gly Arg Ala Cys Gly Trp Val Tyr Gln 
            20                  25                  30          

Met Arg Leu Arg Gly Gly Arg Val Met Gly Ala Glu Lys Asp Val Tyr 
        35                  40                  45              

Ser Arg Leu Arg Gly Ser Ile Val Pro Met Val Thr Pro Phe Leu Glu 
    50                  55                  60                  

Asp Gly Ser Phe Asp Glu Lys Ser Tyr Arg Glu Leu Ile Glu Trp Gln 
65                  70                  75                  80  

Ile Glu Ser Gly Ser His Gly Ile Ser Cys Ala Gly Thr Thr Gly Glu 
                85                  90                  95      

Pro Ser Ser Leu Thr Ile Glu Glu Arg Glu Tyr Leu Phe Glu Val Thr 
            100                 105                 110         

Met Asp Ala Val Arg Gly Arg Val Pro Val Val Leu Gly Thr Gly Ser 
        115                 120                 125             

Thr Asn His Ala Glu Ala Leu Arg Leu Thr Lys Thr Ala Glu Arg Leu 
    130                 135                 140                 

Gly Ala Asp Ala Ala Leu Val Ile Val Pro Tyr Tyr Asn Arg Pro Ser 
145                 150                 155                 160 

Gln Glu Gly Leu Tyr Arg His Phe Arg Ala Ile Ala Asp Ser Val Asp 
                165                 170                 175     

Ile Pro Ile Ile Leu Tyr Asn Ile Pro Gly Arg Thr Gly Val Asn Leu 
            180                 185                 190         

Glu Pro Ala Thr Met Ala Arg Leu Arg Arg Asp Cys Arg Asn Ile Ile 
        195                 200                 205             

Gly Val Lys Glu Ser Asn Lys Asp Phe Glu Gln Val Thr Arg Val Phe 
    210                 215                 220                 

Gln Ala Cys Gly Arg Asp Phe Leu Val Tyr Ser Gly Ile Glu Leu Leu 
225                 230                 235                 240 

Cys Tyr Pro Met Leu Ala Leu Gly Gly Ala Gly His Leu Ser Ala Thr 
                245                 250                 255     

Ala Asn Leu Met Pro Arg Glu Val Ala Arg Leu Tyr Asp Leu Val Gln 
            260                 265                 270         

Ala Gly Lys Trp His Glu Ala Ile Asp Leu His Phe Gln Leu Val Asp 
        275                 280                 285             

Ile Asn Glu Ala Leu Phe Trp Glu Thr Asn Pro Gly Pro Val Lys Ala 
    290                 295                 300                 

Cys Leu Ala Met Met Gly Lys Ile Arg Pro Val Val Arg Pro Pro Leu 
305                 310                 315                 320 

Ala Leu Pro Gly Glu Glu Met Thr Ala Lys Leu Arg Gly Val Leu Thr 
                325                 330                 335     

Ser Tyr Gly Leu Ile 
            340     

<210>   1575
<211>   341
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1565

<400>   1575
Met Val Ala Gly Arg Asp Gly Gly His Gly Leu Gly Thr Gln Arg Ser 
                5                   10                  15      

Arg Arg Thr Val Arg Asp Asp Gly Arg Ala Cys Gly Trp Val Tyr Gln 
            20                  25                  30          

Met Arg Leu Arg Gly Gly Arg Val Met Gly Ala Glu Lys Asp Val Tyr 
        35                  40                  45              

Ser Arg Leu Arg Gly Ser Ile Val Pro Met Val Thr Pro Phe Leu Glu 
    50                  55                  60                  

Asp Gly Ser Phe Asp Glu Lys Ser Tyr Arg Glu Leu Ile Glu Trp Gln 
65                  70                  75                  80  

Ile Glu Ser Gly Ser His Gly Ile Ser Cys Ala Gly Thr Thr Gly Glu 
                85                  90                  95      

Pro Ser Ser Leu Thr Ile Glu Glu Arg Glu Tyr Leu Phe Glu Val Thr 
            100                 105                 110         

Met Asp Ala Val Lys Gly Arg Val Pro Val Val Leu Gly Thr Gly Ser 
        115                 120                 125             

Thr Asn His Ala Glu Ala Leu Arg Leu Thr Lys Thr Ala Glu Arg Leu 
    130                 135                 140                 

Gly Ala Asp Ala Ala Leu Val Ile Val Pro Tyr Tyr Asn Arg Pro Ser 
145                 150                 155                 160 

Gln Glu Gly Leu Tyr Arg His Phe Arg Ala Ile Ala Asp Ser Val Asp 
                165                 170                 175     

Ile Pro Ile Ile Leu Tyr Asn Ile Pro Gly Arg Thr Gly Val Asn Leu 
            180                 185                 190         

Glu Pro Ala Thr Met Ala Arg Leu Lys Arg Asp Cys Arg Asn Ile Ile 
        195                 200                 205             

Gly Val Lys Glu Ser Asn Lys Asp Phe Glu Gln Val Thr Arg Val Phe 
    210                 215                 220                 

Gln Ala Cys Gly Arg Asp Phe Leu Val Tyr Ser Gly Ile Glu Leu Leu 
225                 230                 235                 240 

Cys Tyr Pro Met Leu Ala Leu Gly Gly Ala Gly His Leu Ser Ala Thr 
                245                 250                 255     

Ala Asn Leu Met Pro Arg Glu Val Ala Arg Leu Tyr Asp Leu Val Gln 
            260                 265                 270         

Ala Gly Lys Trp His Glu Ala Ile Asp Leu His Phe Gln Leu Val Asp 
        275                 280                 285             

Ile Asn Glu Ala Leu Phe Trp Glu Thr Asn Pro Gly Pro Val Lys Ala 
    290                 295                 300                 

Cys Leu Ala Met Met Gly Lys Ile Arg Pro Val Val Arg Pro Pro Leu 
305                 310                 315                 320 

Ala Leu Pro Gly Glu Glu Met Thr Ala Lys Leu Arg Gly Val Leu Thr 
                325                 330                 335     

Ser Tyr Gly Leu Ile 
            340     

<210>   1576
<211>   341
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1565

<400>   1576
Met Val Ala Gly Arg Asp Gly Gly His Gly Leu Gly Thr Gln Arg Ser 
                5                   10                  15      

Arg Arg Thr Val Arg Asp Asp Gly Arg Ala Cys Gly Trp Val Tyr Gln 
            20                  25                  30          

Met Arg Leu Arg Gly Gly Arg Val Met Gly Ala Glu Lys Asp Val Tyr 
        35                  40                  45              

Ser Arg Leu Arg Gly Ser Ile Val Pro Met Val Thr Pro Phe Leu Glu 
    50                  55                  60                  

Asp Gly Ser Phe Asp Glu Lys Ser Tyr Arg Glu Leu Ile Glu Trp Gln 
65                  70                  75                  80  

Ile Glu Ser Gly Ser His Gly Ile Ser Cys Ala Gly Thr Thr Gly Glu 
                85                  90                  95      

Pro Ser Ser Leu Thr Ile Glu Glu Arg Glu Tyr Leu Phe Glu Val Thr 
            100                 105                 110         

Met Asp Ala Val Arg Gly Arg Val Pro Val Val Leu Gly Thr Gly Ser 
        115                 120                 125             

Thr Asn His Ala Glu Ala Leu Arg Leu Thr Lys Thr Ala Glu Arg Leu 
    130                 135                 140                 

Gly Ala Asp Ala Ala Leu Val Ile Val Pro Tyr Tyr Asn Arg Pro Ser 
145                 150                 155                 160 

Gln Glu Gly Leu Tyr Arg His Phe Arg Ala Ile Ala Asp Ser Val Asp 
                165                 170                 175     

Ile Pro Ile Ile Leu Tyr Asn Ile Pro Gly Arg Thr Gly Val Asn Leu 
            180                 185                 190         

Glu Pro Ala Thr Met Ala Arg Leu Lys Arg Asp Cys Arg Asn Ile Ile 
        195                 200                 205             

Gly Val Lys Glu Ser Asn Lys Asp Phe Glu Gln Val Thr Arg Val Phe 
    210                 215                 220                 

Gln Ala Cys Gly Arg Asp Phe Leu Val Tyr Ser Gly Ile Glu Leu Leu 
225                 230                 235                 240 

Cys Tyr Pro Met Leu Ala Leu Gly Gly Ala Gly His Leu Ser Ala Thr 
                245                 250                 255     

Ala Asn Leu Met Pro Arg Glu Val Ala Arg Leu Tyr Asp Leu Val Gln 
            260                 265                 270         

Ala Gly Lys Trp His Glu Ala Ile Asp Leu His Phe Gln Leu Val Asp 
        275                 280                 285             

Leu Asn Glu Ala Leu Phe Trp Glu Thr Asn Pro Gly Pro Val Lys Ala 
    290                 295                 300                 

Cys Leu Ala Met Met Gly Lys Ile Arg Pro Val Val Arg Pro Pro Leu 
305                 310                 315                 320 

Ala Leu Pro Gly Glu Glu Met Thr Ala Lys Leu Arg Gly Val Leu Thr 
                325                 330                 335     

Ser Tyr Gly Leu Ile 
            340     

<210>   1577
<211>   1026
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1566

<400>   1577
ttggtggcgg gacgggacgg tggtcatgga ttgggaacgc aacgttcccg tcgaactatt       60

cgggacgacg gacgcgcgtg cggctgggta tatcaaatga gactgcgagg gggacgggtc      120

atgggcgccg aaaaggacgt gtattcgcgc cttcggggat ccatcgtgcc gatggtcacg      180

ccgtttttgg aggacggatc gtttgacgag aagtcgtatc gtgaactcat tgagtggcag      240

atcgagagcg gttctcacgg tatctcttgc gcaggaacaa ctggagaacc gagttccctt      300

acgatagaag aacgagaata cttattcgaa gtcacgatgg atgccgtgcg cggtcgggtg      360

cctgtggtgt tggggacggg ctcgacgaac cacgcggagg cgcttcggct cacgaagacg      420

gctgaacggc tgggtgcgga tgccgcgctg gtcatcgttc cgtattacaa ccgtccgtcc      480

caggaggggc tctaccggca ctttcgcgcg atagcggaca gcgtcgacat tcccatcatc      540

ctgtacaaca ttccgggacg caccggggtg aacctagagc ccgccacgat ggcccggctc      600

aagcgcgact gccgtaacat cattggcgtc aaggaatcga acaaggactt tgagcaggtt      660

acacgcgtgt tccaggcctg cggccgcgat ttcctggtct attccggcat agagctcctg      720

tgttacccca tgctcgcgct gggaggagcg gggcatctca gcgcgaccgc caatctcatg      780

ccgagagaag tcgcccgcct gtacgacttg gtgcaagccg ggaagtggca tgaagcgatc      840

gatcttcact ttcaactggt cgacatcaat gaggctttgt tctgggagac gaacccaggt      900

ccggtcaagg cgtgccttgc catgatgggc aaaattcggc ccgtggtgag gccgccgctc      960

gcgctgccag gagaggaaat gacggcaaag ctgcgaggcg tgctgacttc gtatgggctg     1020

atctga                                                                1026


<210>   1578
<211>   1026
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1566

<400>   1578
ttggtggcgg gacgggacgg tggtcatgga ttgggaacgc aacgttcccg tcgaactgtg       60

cgggacgacg gacgcgcgtg cggctgggta tatcaaatga gactgcgagg gggacgggtc      120

atgggcgccg aaaaggacgt gtattcgcgc cttcggggat ccatcgtgcc gatggtcacg      180

ccgtttttgg aggacggatc gtttgacgag aagtcgtatc gtgaactcat tgagtggcag      240

atcgagagcg gttctcacgg tatctcttgc gcaggaacaa ctggagaacc gagttccctt      300

acgatagaag aacgagaata cttattcgaa gtcacgatgg atgccgtgcg cggtcgggtg      360

cctgtggtgt tggggacggg ctcgacgaac cacgcggagg cgcttcggct cacgaagacg      420

gctgaacggc tgggtgcgga tgccgcgctg gtcatcgttc cgtattacaa ccgtccgtcc      480

caggaggggc tctaccggca ctttcgcgcg atagcggaca gcgtcgacat tcccatcatc      540

ctgtacaaca ttccgggacg caccggggtg aacctagagc ccgccacgat ggcccggctc      600

aagcgcgact gccgtaacat cattggcgtc aaggaatcga acaaggactt tgagcaggtt      660

acacgcgtgt tccaggcctg cggccgcgat ttcctggtct attccggcat agagctcctg      720

tgttacccca tgctcgcgct gggaggagcg gggcatctca gcgcgaccgc caatctcatg      780

ccgagagaag tcgcccgcct gtacgacatt gtgcaagccg ggaagtggca tgaagcgatc      840

gatcttcact ttcaactggt cgacatcaat gaggctttgt tctgggagac gaacccaggt      900

ccggtcaagg cgtgccttgc catgatgggc aaaattcggc ccgtggtgag gccgccgctc      960

gcgctgccag gagaggaaat gacggcaaag ctgcgaggcg tgctgacttc gtatgggctg     1020

atctga                                                                1026


<210>   1579
<211>   1026
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1566

<400>   1579
ttggtggcgg gacgggacgg tggtcatgga ttgggaacgc aacgttcccg tcgaactgtg       60

cgggacgacg gacgcgcgtg cggctgggta tatcaaatga gactgcgagg gggacgggtc      120

atgggcgccg aaaaggacgt gtattcgcgc cttcggggat ccatcgtgcc gatggtcacg      180

ccgtttttgg aggacggatc gtttgacgag aagtcgtatc gtgaactcat tgagtggcag      240

atcgagagcg gttctcacgg tatctcttgc gcaggaacaa ctggagaacc gagttccctt      300

acgatagaag aacgagaata cttattcgaa gtcacgatgg atgccgtgcg cggtcgggtg      360

cctgtggtgt tggggacggg ctcgacgaac cacgcggagg cgcttcggct cacgaagacg      420

gctgaacggc tgggtgcgga tgccgcgctg gtcatcgttc cgtattacaa ccgtccgtcc      480

caggaggggc tctaccggca ctttcgcgcg atagcggaca gcgtcgacat tcccatcatc      540

ctgtacaaca ttccgggacg caccggggtg aacctagagc ccgccacgat ggcccggctc      600

cgtcgcgact gccgtaacat cattggcgtc aaggaatcga acaaggactt tgagcaggtt      660

acacgcgtgt tccaggcctg cggccgcgat ttcctggtct attccggcat agagctcctg      720

tgttacccca tgctcgcgct gggaggagcg gggcatctca gcgcgaccgc caatctcatg      780

ccgagagaag tcgcccgcct gtacgacttg gtgcaagccg ggaagtggca tgaagcgatc      840

gatcttcact ttcaactggt cgacatcaat gaggctttgt tctgggagac gaacccaggt      900

ccggtcaagg cgtgccttgc catgatgggc aaaattcggc ccgtggtgag gccgccgctc      960

gcgctgccag gagaggaaat gacggcaaag ctgcgaggcg tgctgacttc gtatgggctg     1020

atctga                                                                1026


<210>   1580
<211>   1026
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1566

<400>   1580
ttggtggcgg gacgggacgg tggtcatgga ttgggaacgc aacgttcccg tcgaactgtg       60

cgggacgacg gacgcgcgtg cggctgggta tatcaaatga gactgcgagg gggacgggtc      120

atgggcgccg aaaaggacgt gtattcgcgc cttcggggat ccatcgtgcc gatggtcacg      180

ccgtttttgg aggacggatc gtttgacgag aagtcgtatc gtgaactcat tgagtggcag      240

atcgagagcg gttctcacgg tatctcttgc gcaggaacaa ctggagaacc gagttccctt      300

acgatagaag aacgagaata cttattcgaa gtcacgatgg atgccgtgaa aggtcgggtg      360

cctgtggtgt tggggacggg ctcgacgaac cacgcggagg cgcttcggct cacgaagacg      420

gctgaacggc tgggtgcgga tgccgcgctg gtcatcgttc cgtattacaa ccgtccgtcc      480

caggaggggc tctaccggca ctttcgcgcg atagcggaca gcgtcgacat tcccatcatc      540

ctgtacaaca ttccgggacg caccggggtg aacctagagc ccgccacgat ggcccggctc      600

aagcgcgact gccgtaacat cattggcgtc aaggaatcga acaaggactt tgagcaggtt      660

acacgcgtgt tccaggcctg cggccgcgat ttcctggtct attccggcat agagctcctg      720

tgttacccca tgctcgcgct gggaggagcg gggcatctca gcgcgaccgc caatctcatg      780

ccgagagaag tcgcccgcct gtacgacttg gtgcaagccg ggaagtggca tgaagcgatc      840

gatcttcact ttcaactggt cgacatcaat gaggctttgt tctgggagac gaacccaggt      900

ccggtcaagg cgtgccttgc catgatgggc aaaattcggc ccgtggtgag gccgccgctc      960

gcgctgccag gagaggaaat gacggcaaag ctgcgaggcg tgctgacttc gtatgggctg     1020

atctga                                                                1026


<210>   1581
<211>   1026
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1566

<400>   1581
ttggtggcgg gacgggacgg tggtcatgga ttgggaacgc aacgttcccg tcgaactgtg       60

cgggacgacg gacgcgcgtg cggctgggta tatcaaatga gactgcgagg gggacgggtc      120

atgggcgccg aaaaggacgt gtattcgcgc cttcggggat ccatcgtgcc gatggtcacg      180

ccgtttttgg aggacggatc gtttgacgag aagtcgtatc gtgaactcat tgagtggcag      240

atcgagagcg gttctcacgg tatctcttgc gcaggaacaa ctggagaacc gagttccctt      300

acgatagaag aacgagaata cttattcgaa gtcacgatgg atgccgtgcg cggtcgggtg      360

cctgtggtgt tggggacggg ctcgacgaac cacgcggagg cgcttcggct cacgaagacg      420

gctgaacggc tgggtgcgga tgccgcgctg gtcatcgttc cgtattacaa ccgtccgtcc      480

caggaggggc tctaccggca ctttcgcgcg atagcggaca gcgtcgacat tcccatcatc      540

ctgtacaaca ttccgggacg caccggggtg aacctagagc ccgccacgat ggcccggctc      600

aagcgcgact gccgtaacat cattggcgtc aaggaatcga acaaggactt tgagcaggtt      660

acacgcgtgt tccaggcctg cggccgcgat ttcctggtct attccggcat agagctcctg      720

tgttacccca tgctcgcgct gggaggagcg gggcatctca gcgcgaccgc caatctcatg      780

ccgagagaag tcgcccgcct gtacgacttg gtgcaagccg ggaagtggca tgaagcgatc      840

gatcttcact ttcaactggt cgacttaaat gaggctttgt tctgggagac gaacccaggt      900

ccggtcaagg cgtgccttgc catgatgggc aaaattcggc ccgtggtgag gccgccgctc      960

gcgctgccag gagaggaaat gacggcaaag ctgcgaggcg tgctgacttc gtatgggctg     1020

atctga                                                                1026
