<110>   Battelle Energy Alliance, LLC
        Thompson, David N
        Apel, William A
        Thompson, Vicki S
        Reed, David W
	Lacey, Jeffrey A

<120>   TRANSCRIPTIONAL CONTROL IN ALICYCLOBACILLUS ACIDOCALDARIUS 
        AND ASSOCIATED GENES, PROTEINS, AND METHODS

<130>   2939-8661PC(BA-283B)

<150>  US 61/031,593
<151>  2008-02-26

<160>   782

<170>	INL Custom Script Ver 1.0 (Author: Cody Permann)

<210>   1
<211>   321
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1
Met Ala Thr Val Met Glu Met Arg Arg Ser His Gly Arg Glu Arg Ala 
                5                   10                  15      

Lys Arg Arg Val Asp Trp Val Ala Tyr Gly Tyr Leu Ser Pro Ala Leu 
            20                  25                  30          

Val Thr Ile Cys Val Leu Ser Ile Leu Pro Ile Phe Tyr Thr Ile Tyr 
        35                  40                  45              

Ile Ser Phe Thr Asn Phe Asn Gln Met His Phe Leu Ser Tyr Gln Phe 
    50                  55                  60                  

Val Gly Leu Lys Asn Tyr Glu Glu Leu Leu Asn Pro His Asp Pro Leu 
65                  70                  75                  80  

Ser Asn Leu Phe Leu Pro Thr Phe Ile Trp Thr Leu Val Tyr Ala Leu 
                85                  90                  95      

Cys Thr Thr Ala Leu Ala Tyr Leu Val Gly Leu Phe Leu Ala Val Leu 
            100                 105                 110         

Leu Asn Asn Lys His Met Arg Glu Arg Thr Leu Tyr Arg Thr Leu Leu 
        115                 120                 125             

Ile Val Pro Trp Ala Val Pro Asn Leu Ile Ser Met Leu Ala Trp Gln 
    130                 135                 140                 

Gly Leu Leu Asn Asp Gln Tyr Gly Gln Ile Asn Ala Leu Leu His Gly 
145                 150                 155                 160 

Val Phe Gly Leu Pro Arg Ile Pro Trp Leu Thr Ser Ala Leu Trp Ala 
                165                 170                 175     

Arg Ile Ala Val Ile Met Val Asn Val Trp Ala Gly Phe Pro Tyr Met 
            180                 185                 190         

Met Thr Val Cys Leu Gly Ala Leu Gln Ser Ile Pro Thr Asp Gln Tyr 
        195                 200                 205             

Glu Ala Ala Glu Ile Asp Gly Ala Asn Trp Trp Gln Val Phe Arg Tyr 
    210                 215                 220                 

Val Thr Met Pro Ser Val Trp Arg Ile Ser Leu Pro Leu Leu Ile Pro 
225                 230                 235                 240 

Ser Phe Ser Tyr Asn Phe Asn Asn Phe Asn Ala Ser Tyr Leu Leu Thr 
                245                 250                 255     

Gly Gly Gly Pro Pro Asn Ser Asn Asn Pro Phe Leu Gly Gln Thr Asp 
            260                 265                 270         

Ile Leu Ala Thr Ala Ala Tyr Lys Met Thr Leu Thr Phe Asn Arg Tyr 
        275                 280                 285             

Asp Leu Gly Ala Thr Ile Ser Val Leu Leu Phe Ile Leu Val Ala Leu 
    290                 295                 300                 

Ile Ser Trp Val Gln Met Arg Tyr Thr Gly Ala Phe Lys Glu Val Asp 
305                 310                 315                 320 

Ala 
    

<210>   2
<211>   966
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   2
atggccaccg tcatggagat gagaaggtct cacggccggg agcgcgcaaa gcggcgcgtg       60

gattgggtcg cctacgggta cctctctcca gcgctcgtca ccatctgtgt tctcagcatc      120

ctacccattt tttacactat atacatctcg tttactaatt ttaatcaaat gcactttctt      180

tcttatcagt tcgtaggttt gaagaactat gaggaacttt taaatccgca tgatccgttg      240

tcgaatctat ttttgccgac attcatctgg accttggtgt acgcgctctg taccacggcg      300

ctcgcgtatc tcgtgggatt gttcctcgcc gtcctactca ataacaaaca catgcgggag      360

cgcactctct atcgaacact gctcatcgtg ccttgggcgg ttccgaacct catttcaatg      420

ctcgcatggc agggcctgtt gaacgatcag tacgggcaaa tcaatgcact tttgcatggc      480

gtgtttggcc tgccgcgcat tccctggctc acgagcgcgt tatgggctcg aatcgctgtc      540

atcatggtca atgtttgggc cggttttccc tacatgatga ccgtttgttt aggtgctctg      600

cagtcgatcc cgaccgacca atatgaggcc gcggaaattg acggagccaa ctggtggcaa      660

gtgtttcggt atgtgaccat gccttcggtg tggcgaatct ctttgccgct cctgataccg      720

tctttttcat acaactttaa caacttcaac gcatcgtatc tgttgactgg aggcggaccg      780

cccaattcga acaacccatt cctgggtcaa acggacattt tggcaactgc ggcctacaaa      840

atgactctta cgttcaatcg ctacgactta ggagcgacga tttccgttct gctgttcatt      900

cttgtggctc ttatcagctg ggtgcagatg cgctataccg gagcctttaa ggaggtcgat      960

gcgtga                                                                 966


<210>   3
<211>   321
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   3
Met Ala Thr Val Met Glu Met Arg Arg Ser His Gly Arg Glu Arg Ala 
                5                   10                  15      

Lys Arg Arg Val Asp Trp Val Ala Tyr Gly Tyr Leu Ser Pro Ala Leu 
            20                  25                  30          

Val Thr Ile Cys Val Leu Ser Ile Leu Pro Ile Phe Tyr Thr Ile Tyr 
        35                  40                  45              

Ile Ser Phe Thr Asn Phe Asn Gln Met His Phe Leu Ser Tyr Gln Phe 
    50                  55                  60                  

Val Gly Leu Lys Asn Tyr Glu Glu Leu Leu Asn Pro His Asp Pro Leu 
65                  70                  75                  80  

Ser Asn Leu Phe Leu Pro Thr Phe Ile Trp Thr Leu Val Tyr Ala Leu 
                85                  90                  95      

Cys Thr Thr Ala Leu Ala Tyr Leu Val Gly Leu Phe Leu Ala Val Leu 
            100                 105                 110         

Leu Asn Asn Lys His Met Arg Glu Arg Thr Leu Tyr Arg Thr Leu Leu 
        115                 120                 125             

Ile Val Pro Trp Ala Val Pro Asn Leu Ile Ser Met Leu Ala Trp Gln 
    130                 135                 140                 

Gly Leu Leu Asn Asp Gln Tyr Gly Gln Ile Asn Ala Leu Leu His Gly 
145                 150                 155                 160 

Val Phe Gly Leu Pro Arg Ile Pro Trp Leu Thr Ser Ala Leu Trp Ala 
                165                 170                 175     

Arg Ile Ala Val Ile Met Val Asn Val Trp Ala Gly Phe Pro Tyr Met 
            180                 185                 190         

Met Thr Val Cys Leu Gly Ala Leu Gln Ser Ile Pro Thr Asp Gln Tyr 
        195                 200                 205             

Glu Ala Ala Glu Ile Asp Gly Ala Asn Trp Trp Gln Val Phe Arg Tyr 
    210                 215                 220                 

Val Thr Met Pro Ser Val Trp Arg Ile Ser Leu Pro Leu Leu Ile Pro 
225                 230                 235                 240 

Ser Phe Ser Tyr Asn Phe Asn Asn Phe Asn Ala Ser Tyr Leu Leu Thr 
                245                 250                 255     

Gly Gly Gly Pro Pro Asn Ser Asn Asn Pro Phe Leu Gly Gln Thr Asp 
            260                 265                 270         

Ile Leu Ala Thr Ala Ala Tyr Lys Met Thr Leu Thr Phe Asn Arg Tyr 
        275                 280                 285             

Asp Leu Gly Ala Thr Ile Ser Val Leu Leu Phe Ile Leu Val Ala Leu 
    290                 295                 300                 

Ile Ser Trp Val Gln Met Arg Tyr Thr Gly Ala Phe Lys Glu Val Asp 
305                 310                 315                 320 

Ala 
    

<210>   4
<211>   293
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   4
Tyr Ala Tyr Leu Ser Pro Ala Ile Leu Ser Met Thr Val Leu Ser Phe 
                5                   10                  15      

Ala Pro Met Ala Tyr Thr Ile Tyr Ile Ala Phe Thr Asn Phe Asn Leu 
            20                  25                  30          

Tyr His Phe Lys Asn Tyr Gln Phe Val Gly Phe Lys Asn Phe Val Asp 
        35                  40                  45              

Ile Leu Thr Gly Pro Phe Lys Asn Val Phe Ala Pro Val Phe Val Trp 
    50                  55                  60                  

Thr Val Ile Tyr Ala Leu Ser Ala Thr Leu Leu Ser Tyr Ile Val Gly 
65                  70                  75                  80  

Leu Leu Leu Ala Val Ile Leu Asn Asn Lys His Met Trp Glu Thr Asn 
                85                  90                  95      

Phe Tyr Arg Ala Ile Leu Ile Ile Pro Trp Gly Leu Pro Gly Thr Ile 
            100                 105                 110         

Ala Val Leu Thr Trp Thr Gly Leu Leu Asn Gln Gln Tyr Gly Gly Ile 
        115                 120                 125             

Asn Leu Ile Leu Gln Lys Leu His Leu Pro Met Ile Pro Trp Leu Leu 
    130                 135                 140                 

Glu Pro Phe Trp Ala Lys Val Ala Ile Ile Met Val Ser Val Trp Met 
145                 150                 155                 160 

Gly Tyr Pro Phe Met Met Asn Ala Ser Leu Gly Ala Leu Gln Ala Ile 
                165                 170                 175     

Pro Pro Glu Leu Tyr Glu Val Ala Asp Ile Asp Gly Ala Ser Trp Phe 
            180                 185                 190         

Gln Lys Leu Thr Lys Ile Thr Leu Pro Met Leu Thr Ser Ser Thr Leu 
        195                 200                 205             

Pro Leu Ile Ile Ser Ser Phe Ala Tyr Asn Phe Asn Asn Phe Gly Thr 
    210                 215                 220                 

Ala Phe Leu Ile Thr Gly Gly Gly Pro Pro Arg Thr Asp Thr Ser Phe 
225                 230                 235                 240 

Ala Gly His Thr Asp Ile Leu Val Ser Ala Ala Tyr Lys Leu Thr Met 
                245                 250                 255     

Gln Ala Asn Arg Tyr Asp Leu Ala Ala Ala Leu Ser Ile Ile Ile Phe 
            260                 265                 270         

Leu Ile Ile Gly Thr Leu Ser Leu Leu Asn Met Arg Leu Thr Gly Ala 
        275                 280                 285             

Phe Lys Glu Val Asp 
    290             

<210>   5
<211>   293
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   5
Tyr Ala Tyr Leu Ser Pro Ala Ile Leu Ser Met Thr Val Leu Ser Phe 
                5                   10                  15      

Ala Pro Ile Leu Tyr Thr Ile Tyr Ile Ala Phe Thr Asn Phe Asn Leu 
            20                  25                  30          

Tyr His Phe Lys Asn Tyr Gln Phe Val Gly Phe Lys Asn Phe Val Asp 
        35                  40                  45              

Ile Leu Ala Gly Pro Phe Lys Val Val Phe Ala Pro Val Phe Val Trp 
    50                  55                  60                  

Thr Val Ile Phe Ala Leu Ser Ala Thr Leu Leu Ser Tyr Ile Ile Gly 
65                  70                  75                  80  

Leu Leu Leu Ala Val Ile Leu Asn Asn Lys Asn Met Trp Glu Thr Asn 
                85                  90                  95      

Leu Tyr Arg Ala Ile Leu Ile Ile Pro Trp Gly Leu Pro Gly Thr Ile 
            100                 105                 110         

Ala Ala Leu Thr Trp Thr Gly Leu Leu Asn Gln Gln Tyr Gly Gly Ile 
        115                 120                 125             

Asn Leu Ile Leu Gln Lys Leu His Leu Pro Met Ile Pro Trp Leu Leu 
    130                 135                 140                 

Asp Pro Phe Trp Ala Arg Val Ala Ile Ile Ile Val Ser Val Trp Met 
145                 150                 155                 160 

Gly Tyr Pro Phe Met Met Asn Ala Ser Leu Gly Ala Leu Gln Ala Ile 
                165                 170                 175     

Pro Pro Glu Leu Tyr Glu Val Ala Asp Ile Asp Gly Ala Thr Trp Phe 
            180                 185                 190         

Gln Lys Phe Arg Met Ile Thr Val Pro Met Leu Thr Ser Ser Thr Leu 
        195                 200                 205             

Pro Leu Ile Ile Ser Ser Phe Ala Tyr Asn Phe Asn Asn Phe Gly Ala 
    210                 215                 220                 

Ala Phe Leu Ile Thr Gly Gly Gly Pro Pro Arg Thr Asp Thr Ser Phe 
225                 230                 235                 240 

Ala Gly His Thr Asp Leu Leu Val Ser Ser Ala Tyr Lys Met Thr Met 
                245                 250                 255     

Gln Phe Asn Arg Tyr Asp Leu Ala Ala Ala Leu Ser Ile Ile Ile Phe 
            260                 265                 270         

Leu Ile Ile Gly Thr Leu Ser Leu Ile Asn Met Lys Met Thr Arg Ala 
        275                 280                 285             

Phe Glu Glu Val Asp 
    290             

<210>   6
<211>   292
<212>   PRT
<213>   Caldicellulosiruptor saccharolyticus DSM 8903

<400>   6
Ile Gly Tyr Val Tyr Leu Ala Pro Ala Leu Ile Ser Met Ala Val Leu 
                5                   10                  15      

Ser Phe Phe Pro Ile Ala Met Thr Val Tyr Tyr Ala Phe Thr Asn Phe 
            20                  25                  30          

Asn Leu Asn His Met Glu Asp Tyr Lys Phe Val Gly Phe Lys Asn Phe 
        35                  40                  45              

Val Asp Ile Ile Thr Gly Pro Phe Lys Glu Val Phe Ala Pro Thr Phe 
    50                  55                  60                  

Ala Trp Thr Phe Thr Phe Ala Leu Ile Thr Val Leu Ile Asn Phe Ala 
65                  70                  75                  80  

Val Gly Leu Leu Leu Ala Val Leu Leu Asn Asn Lys Phe Met Lys Glu 
                85                  90                  95      

Thr Asn Ile Tyr Arg Ser Ile Leu Ile Ile Pro Trp Ala Ile Pro Gly 
            100                 105                 110         

Thr Ile Ala Ser Leu Ala Trp Gln Gly Leu Leu Asn Glu Glu Tyr Gly 
        115                 120                 125             

Ala Ile Asn Met Leu Leu Lys Thr Phe Arg Leu Asn Pro Ile Pro Trp 
    130                 135                 140                 

Met Thr Asp Pro Phe Trp Ala Lys Ile Ser Ile Phe Ile Val Asn Leu 
145                 150                 155                 160 

Trp Leu Ser Tyr Pro Phe Met Met Asn Ala Ser Leu Gly Ala Leu Gln 
                165                 170                 175     

Ser Ile Pro Pro Glu Leu Tyr Glu Val Ala Glu Ile Asp Gly Ala Gly 
            180                 185                 190         

Trp Phe Thr Lys Leu Phe Lys Ile Thr Ile Pro Met Ile Val Pro Thr 
        195                 200                 205             

Ala Leu Pro Ile Leu Ile Ser Ser Phe Ala Tyr Ala Phe Asn Asn Phe 
    210                 215                 220                 

Asn Val Val Tyr Leu Val Thr Gly Gly Gly Pro Ala Arg Leu Asp Thr 
225                 230                 235                 240 

Gln Phe Ala Gly His Thr Asp Leu Leu Val Ser Thr Thr Tyr Lys Leu 
                245                 250                 255     

Thr Met Gln Phe Tyr Arg Tyr Asp Leu Ala Ser Ala Met Ser Ile Ile 
            260                 265                 270         

Ile Phe Phe Ile Val Gly Thr Ile Ser Leu Ile Asn Met Lys Leu Thr 
        275                 280                 285             

Arg Ala Phe Glu 
    290         

<210>   7
<211>   307
<212>   PRT
<213>   Clostridium perfringens SM101

<400>   7
Lys Lys Gln Lys Arg Leu Lys Asp Thr Ile Lys Ala Met Pro Tyr Leu 
                5                   10                  15      

Leu Pro Ala Leu Ile Ser Ile Ile Ile Phe Thr Ile Ile Pro Ile Val 
            20                  25                  30          

Tyr Thr Val Val Ile Ala Phe Thr Asp Tyr Thr Met Tyr Ser Gln Gly 
        35                  40                  45              

His Ile Lys Phe Val Gly Phe Ala Asn Phe Ile Glu Val Leu Thr Gly 
    50                  55                  60                  

Pro Phe Lys Glu Val Phe Leu Pro Val Phe Val Trp Asn Ile Ile Phe 
65                  70                  75                  80  

Ala Val Val Ser Thr Ala Gly Thr Phe Phe Leu Gly Leu Ile Val Ala 
                85                  90                  95      

Met Ala Val Asn Asn Pro Asn Ile Lys Glu Lys Ser Val Tyr Arg Ala 
            100                 105                 110         

Ile Leu Ile Ile Pro Trp Ala Leu Pro Ala Thr Val Ala Ile Leu Ser 
        115                 120                 125             

Trp Gln Gly Leu Leu Asn Gly Ser Tyr Gly Ala Ile Asn Asn Leu Leu 
    130                 135                 140                 

Leu Asn Leu His Leu Ile Ser Asn Pro Ile Pro Trp Leu Thr Asp Pro 
145                 150                 155                 160 

Thr Trp Ala Arg Val Ala Leu Ile Ile Val Asn Ile Trp Leu Gly Phe 
                165                 170                 175     

Pro Tyr Met Met Asn Val Cys Leu Gly Ala Leu Gly Ala Ile Pro Asp 
            180                 185                 190         

Ser Tyr Tyr Glu Ala Ala Asp Val Asp Gly Ala Ser Lys Trp Leu Gln 
        195                 200                 205             

Phe Arg Lys Ile Thr Leu Pro Ser Leu Ala Gln Ile Ser Tyr Pro Leu 
    210                 215                 220                 

Leu Ile Ser Ser Phe Ala Phe Asn Phe Asn Asn Phe Gly Ser Ala Phe 
225                 230                 235                 240 

Leu Ile Thr Lys Gly Gly Pro Pro Arg Met Ser Thr Gln Phe Ala Gly 
                245                 250                 255     

Tyr Thr Asp Ile Leu Ala Ser Val Asn Tyr Lys Leu Ser Thr Gln Phe 
            260                 265                 270         

Gly Arg Phe Glu Ile Ala Ser Ala Ile Ser Ile Ile Ile Phe Leu Ile 
        275                 280                 285             

Leu Gly Thr Ile Ser Tyr Tyr Gln Met Lys Leu Ser Gly Gln Phe Glu 
    290                 295                 300                 

Glu Val Glu 
305         

<210>   8
<211>   321
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   8
Met Ala Thr Ile Met Glu Met Arg Arg Ser His Gly Arg Glu Arg Ala 
                5                   10                  15      

Lys Arg Arg Val Asp Trp Val Ala Tyr Gly Tyr Leu Ser Pro Ala Leu 
            20                  25                  30          

Val Thr Ile Cys Val Leu Ser Ile Leu Pro Ile Phe Tyr Thr Ile Tyr 
        35                  40                  45              

Ile Ser Phe Thr Asn Phe Asn Gln Met His Phe Leu Ser Tyr Gln Phe 
    50                  55                  60                  

Val Gly Leu Lys Asn Tyr Glu Glu Leu Leu Asn Pro His Asp Pro Leu 
65                  70                  75                  80  

Ser Asn Leu Phe Leu Pro Thr Phe Ile Trp Thr Leu Val Tyr Ala Leu 
                85                  90                  95      

Cys Thr Thr Ala Leu Ala Tyr Leu Val Gly Leu Phe Leu Ala Val Leu 
            100                 105                 110         

Leu Asn Asn Lys His Met Arg Glu Arg Thr Leu Tyr Arg Thr Leu Leu 
        115                 120                 125             

Ile Val Pro Trp Ala Val Pro Asn Leu Ile Ser Met Leu Ala Trp Gln 
    130                 135                 140                 

Gly Leu Leu Asn Asp Gln Tyr Gly Gln Ile Asn Ala Leu Leu His Gly 
145                 150                 155                 160 

Val Phe Gly Leu Pro Arg Ile Pro Trp Leu Thr Ser Ala Leu Trp Ala 
                165                 170                 175     

Arg Ile Ala Val Ile Met Val Asn Val Trp Ala Gly Phe Pro Tyr Met 
            180                 185                 190         

Met Thr Val Cys Leu Gly Ala Leu Gln Ser Ile Pro Thr Asp Gln Tyr 
        195                 200                 205             

Glu Ala Ala Glu Ile Asp Gly Ala Asn Trp Trp Gln Val Phe Arg Tyr 
    210                 215                 220                 

Val Thr Met Pro Ser Val Trp Arg Ile Ser Leu Pro Leu Leu Ile Pro 
225                 230                 235                 240 

Ser Phe Ser Tyr Asn Phe Asn Asn Phe Asn Ala Ser Tyr Leu Leu Thr 
                245                 250                 255     

Gly Gly Gly Pro Pro Asn Ser Asn Asn Pro Phe Leu Gly Gln Thr Asp 
            260                 265                 270         

Ile Leu Ala Thr Ala Ala Tyr Lys Met Thr Leu Thr Phe Asn Arg Tyr 
        275                 280                 285             

Asp Leu Gly Ala Thr Ile Ser Val Leu Leu Phe Ile Leu Val Ala Leu 
    290                 295                 300                 

Ile Ser Trp Val Gln Met Arg Tyr Thr Gly Ala Phe Lys Glu Val Asp 
305                 310                 315                 320 

Ala 
    

<210>   9
<211>   321
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   9
Met Ala Thr Val Met Glu Met Arg Arg Ser His Gly Arg Glu Arg Ala 
                5                   10                  15      

Lys Arg Arg Val Asp Trp Val Ala Tyr Gly Tyr Leu Ser Pro Ala Leu 
            20                  25                  30          

Val Thr Ile Cys Val Leu Ser Ile Leu Pro Ile Phe Tyr Thr Ile Tyr 
        35                  40                  45              

Ile Ser Phe Thr Asn Phe Asn Gln Met His Phe Leu Ser Tyr Gln Phe 
    50                  55                  60                  

Val Gly Leu Lys Asn Tyr Glu Glu Leu Leu Asn Pro His Asp Pro Leu 
65                  70                  75                  80  

Ser Asn Leu Phe Leu Pro Thr Phe Ile Trp Thr Leu Val Tyr Ala Leu 
                85                  90                  95      

Cys Thr Thr Ala Leu Ala Tyr Leu Val Gly Leu Phe Leu Ala Val Leu 
            100                 105                 110         

Leu Asn Asn Lys His Met Arg Glu Arg Thr Leu Tyr Arg Thr Leu Leu 
        115                 120                 125             

Ile Ile Pro Trp Ala Val Pro Asn Leu Ile Ser Met Leu Ala Trp Gln 
    130                 135                 140                 

Gly Leu Leu Asn Asp Gln Tyr Gly Gln Ile Asn Ala Leu Leu His Gly 
145                 150                 155                 160 

Val Phe Gly Leu Pro Arg Ile Pro Trp Leu Thr Ser Ala Leu Trp Ala 
                165                 170                 175     

Arg Ile Ala Val Ile Met Val Asn Val Trp Ala Gly Phe Pro Tyr Met 
            180                 185                 190         

Met Thr Val Cys Leu Gly Ala Leu Gln Ser Ile Pro Thr Asp Gln Tyr 
        195                 200                 205             

Glu Ala Ala Glu Ile Asp Gly Ala Asn Trp Trp Gln Val Phe Arg Tyr 
    210                 215                 220                 

Val Thr Met Pro Ser Val Trp Arg Ile Ser Leu Pro Leu Leu Ile Pro 
225                 230                 235                 240 

Ser Phe Ser Tyr Asn Phe Asn Asn Phe Asn Ala Ser Tyr Leu Leu Thr 
                245                 250                 255     

Gly Gly Gly Pro Pro Asn Ser Asn Asn Pro Phe Leu Gly Gln Thr Asp 
            260                 265                 270         

Ile Leu Ala Thr Ala Ala Tyr Lys Met Thr Leu Thr Phe Asn Arg Tyr 
        275                 280                 285             

Asp Leu Gly Ala Thr Ile Ser Val Leu Leu Phe Ile Leu Val Ala Leu 
    290                 295                 300                 

Ile Ser Trp Val Gln Met Arg Tyr Thr Gly Ala Phe Lys Glu Val Asp 
305                 310                 315                 320 

Ala 
    

<210>   10
<211>   321
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   10
Met Ala Thr Val Met Glu Met Arg Arg Ser His Gly Arg Glu Arg Ala 
                5                   10                  15      

Lys Arg Arg Ile Asp Trp Val Ala Tyr Gly Tyr Leu Ser Pro Ala Leu 
            20                  25                  30          

Val Thr Ile Cys Val Leu Ser Ile Leu Pro Ile Phe Tyr Thr Ile Tyr 
        35                  40                  45              

Ile Ser Phe Thr Asn Phe Asn Gln Met His Phe Leu Ser Tyr Gln Phe 
    50                  55                  60                  

Val Gly Leu Lys Asn Tyr Glu Glu Leu Leu Asn Pro His Asp Pro Leu 
65                  70                  75                  80  

Ser Asn Leu Phe Leu Pro Thr Phe Ile Trp Thr Leu Val Tyr Ala Leu 
                85                  90                  95      

Cys Thr Thr Ala Leu Ala Tyr Leu Val Gly Leu Phe Leu Ala Val Leu 
            100                 105                 110         

Leu Asn Asn Lys His Met Arg Glu Arg Thr Leu Tyr Arg Thr Leu Leu 
        115                 120                 125             

Ile Val Pro Trp Ala Val Pro Asn Leu Ile Ser Met Leu Ala Trp Gln 
    130                 135                 140                 

Gly Leu Leu Asn Asp Gln Tyr Gly Gln Ile Asn Ala Leu Leu His Gly 
145                 150                 155                 160 

Val Phe Gly Leu Pro Arg Ile Pro Trp Leu Thr Ser Ala Leu Trp Ala 
                165                 170                 175     

Arg Ile Ala Val Ile Met Val Asn Val Trp Ala Gly Phe Pro Tyr Met 
            180                 185                 190         

Met Thr Val Cys Leu Gly Ala Leu Gln Ser Ile Pro Thr Asp Gln Tyr 
        195                 200                 205             

Glu Ala Ala Glu Ile Asp Gly Ala Asn Trp Trp Gln Val Phe Arg Tyr 
    210                 215                 220                 

Val Thr Met Pro Ser Val Trp Arg Ile Ser Leu Pro Leu Leu Ile Pro 
225                 230                 235                 240 

Ser Phe Ser Tyr Asn Phe Asn Asn Phe Asn Ala Ser Tyr Leu Leu Thr 
                245                 250                 255     

Gly Gly Gly Pro Pro Asn Ser Asn Asn Pro Phe Leu Gly Gln Thr Asp 
            260                 265                 270         

Ile Leu Ala Thr Ala Ala Tyr Lys Met Thr Leu Thr Phe Asn Arg Tyr 
        275                 280                 285             

Asp Leu Gly Ala Thr Ile Ser Val Leu Leu Phe Ile Leu Val Ala Leu 
    290                 295                 300                 

Ile Ser Trp Val Gln Met Arg Tyr Thr Gly Ala Phe Lys Glu Val Asp 
305                 310                 315                 320 

Ala 
    

<210>   11
<211>   321
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   11
Met Ala Thr Val Met Glu Met Arg Arg Ser His Gly Arg Glu Arg Ala 
                5                   10                  15      

Lys Arg Arg Val Asp Trp Val Ala Tyr Gly Tyr Leu Ser Pro Ala Leu 
            20                  25                  30          

Val Thr Ile Cys Val Leu Ser Ile Leu Pro Ile Phe Tyr Thr Ile Tyr 
        35                  40                  45              

Ile Ser Phe Thr Asn Phe Asn Gln Met His Phe Leu Ser Tyr Gln Phe 
    50                  55                  60                  

Val Gly Leu Lys Asn Tyr Glu Glu Leu Leu Asn Pro His Asp Pro Leu 
65                  70                  75                  80  

Ser Asn Leu Phe Leu Pro Thr Phe Ile Trp Thr Leu Val Tyr Ala Leu 
                85                  90                  95      

Cys Thr Thr Ala Leu Ala Tyr Leu Val Gly Leu Phe Leu Ala Val Leu 
            100                 105                 110         

Leu Asn Asn Lys His Met Arg Glu Arg Thr Leu Tyr Arg Thr Leu Leu 
        115                 120                 125             

Ile Val Pro Trp Ala Val Pro Asn Leu Ile Ser Met Leu Ala Trp Gln 
    130                 135                 140                 

Gly Leu Leu Asn Asp Gln Tyr Gly Gln Ile Asn Ala Leu Leu His Gly 
145                 150                 155                 160 

Val Phe Gly Leu Pro Lys Ile Pro Trp Leu Thr Ser Ala Leu Trp Ala 
                165                 170                 175     

Arg Ile Ala Val Ile Met Val Asn Val Trp Ala Gly Phe Pro Tyr Met 
            180                 185                 190         

Met Thr Val Cys Leu Gly Ala Leu Gln Ser Ile Pro Thr Asp Gln Tyr 
        195                 200                 205             

Glu Ala Ala Glu Ile Asp Gly Ala Asn Trp Trp Gln Val Phe Arg Tyr 
    210                 215                 220                 

Val Thr Met Pro Ser Val Trp Arg Ile Ser Leu Pro Leu Leu Ile Pro 
225                 230                 235                 240 

Ser Phe Ser Tyr Asn Phe Asn Asn Phe Asn Ala Ser Tyr Leu Leu Thr 
                245                 250                 255     

Gly Gly Gly Pro Pro Asn Ser Asn Asn Pro Phe Leu Gly Gln Thr Asp 
            260                 265                 270         

Ile Leu Ala Thr Ala Ala Tyr Lys Met Thr Leu Thr Phe Asn Arg Tyr 
        275                 280                 285             

Asp Leu Gly Ala Thr Ile Ser Val Leu Leu Phe Ile Leu Val Ala Leu 
    290                 295                 300                 

Ile Ser Trp Val Gln Met Arg Tyr Thr Gly Ala Phe Lys Glu Val Asp 
305                 310                 315                 320 

Ala 
    

<210>   12
<211>   321
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   12
Met Ala Thr Val Met Glu Met Arg Arg Ser His Gly Arg Glu Arg Ala 
                5                   10                  15      

Lys Arg Arg Val Asp Trp Val Ala Tyr Gly Tyr Leu Ser Pro Ala Leu 
            20                  25                  30          

Val Thr Ile Cys Val Leu Ser Ile Leu Pro Ile Phe Tyr Thr Ile Tyr 
        35                  40                  45              

Ile Ser Phe Thr Asn Phe Asn Gln Met His Phe Leu Ser Tyr Gln Phe 
    50                  55                  60                  

Val Gly Leu Lys Asn Tyr Glu Glu Leu Leu Asn Pro His Asp Pro Leu 
65                  70                  75                  80  

Ser Asn Leu Phe Leu Pro Thr Phe Ile Trp Thr Leu Val Tyr Ala Leu 
                85                  90                  95      

Cys Thr Thr Ala Leu Ala Tyr Leu Val Gly Leu Phe Leu Ala Val Leu 
            100                 105                 110         

Leu Asn Asn Lys His Met Arg Glu Arg Thr Leu Tyr Arg Thr Leu Leu 
        115                 120                 125             

Ile Val Pro Trp Ala Val Pro Asn Ile Ile Ser Met Leu Ala Trp Gln 
    130                 135                 140                 

Gly Leu Leu Asn Asp Gln Tyr Gly Gln Ile Asn Ala Leu Leu His Gly 
145                 150                 155                 160 

Val Phe Gly Leu Pro Arg Ile Pro Trp Leu Thr Ser Ala Leu Trp Ala 
                165                 170                 175     

Arg Ile Ala Val Ile Met Val Asn Val Trp Ala Gly Phe Pro Tyr Met 
            180                 185                 190         

Met Thr Val Cys Leu Gly Ala Leu Gln Ser Ile Pro Thr Asp Gln Tyr 
        195                 200                 205             

Glu Ala Ala Glu Ile Asp Gly Ala Asn Trp Trp Gln Val Phe Arg Tyr 
    210                 215                 220                 

Val Thr Met Pro Ser Val Trp Arg Ile Ser Leu Pro Leu Leu Ile Pro 
225                 230                 235                 240 

Ser Phe Ser Tyr Asn Phe Asn Asn Phe Asn Ala Ser Tyr Leu Leu Thr 
                245                 250                 255     

Gly Gly Gly Pro Pro Asn Ser Asn Asn Pro Phe Leu Gly Gln Thr Asp 
            260                 265                 270         

Ile Leu Ala Thr Ala Ala Tyr Lys Met Thr Leu Thr Phe Asn Arg Tyr 
        275                 280                 285             

Asp Leu Gly Ala Thr Ile Ser Val Leu Leu Phe Ile Leu Val Ala Leu 
    290                 295                 300                 

Ile Ser Trp Val Gln Met Arg Tyr Thr Gly Ala Phe Lys Glu Val Asp 
305                 310                 315                 320 

Ala 
    

<210>   13
<211>   966
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   13
atggccacca ttatggagat gagaaggtct cacggccggg agcgcgcaaa gcggcgcgtg       60

gattgggtcg cctacgggta cctctctcca gcgctcgtca ccatctgtgt tctcagcatc      120

ctacccattt tttacactat atacatctcg tttactaatt ttaatcaaat gcactttctt      180

tcttatcagt tcgtaggttt gaagaactat gaggaacttt taaatccgca tgatccgttg      240

tcgaatctat ttttgccgac attcatctgg accttggtgt acgcgctctg taccacggcg      300

ctcgcgtatc tcgtgggatt gttcctcgcc gtcctactca ataacaaaca catgcgggag      360

cgcactctct atcgaacact gctcatcgtg ccttgggcgg ttccgaacct catttcaatg      420

ctcgcatggc agggcctgtt gaacgatcag tacgggcaaa tcaatgcact tttgcatggc      480

gtgtttggcc tgccgcgcat tccctggctc acgagcgcgt tatgggctcg aatcgctgtc      540

atcatggtca atgtttgggc cggttttccc tacatgatga ccgtttgttt aggtgctctg      600

cagtcgatcc cgaccgacca atatgaggcc gcggaaattg acggagccaa ctggtggcaa      660

gtgtttcggt atgtgaccat gccttcggtg tggcgaatct ctttgccgct cctgataccg      720

tctttttcat acaactttaa caacttcaac gcatcgtatc tgttgactgg aggcggaccg      780

cccaattcga acaacccatt cctgggtcaa acggacattt tggcaactgc ggcctacaaa      840

atgactctta cgttcaatcg ctacgactta ggagcgacga tttccgttct gctgttcatt      900

cttgtggctc ttatcagctg ggtgcagatg cgctataccg gagcctttaa ggaggtcgat      960

gcgtga                                                                 966


<210>   14
<211>   966
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   14
atggccaccg tcatggagat gagaaggtct cacggccggg agcgcgcaaa gcggcgcgtg       60

gattgggtcg cctacgggta cctctctcca gcgctcgtca ccatctgtgt tctcagcatc      120

ctacccattt tttacactat atacatctcg tttactaatt ttaatcaaat gcactttctt      180

tcttatcagt tcgtaggttt gaagaactat gaggaacttt taaatccgca tgatccgttg      240

tcgaatctat ttttgccgac attcatctgg accttggtgt acgcgctctg taccacggcg      300

ctcgcgtatc tcgtgggatt gttcctcgcc gtcctactca ataacaaaca catgcgggag      360

cgcactctct atcgaacact gctcatcatt ccttgggcgg ttccgaacct catttcaatg      420

ctcgcatggc agggcctgtt gaacgatcag tacgggcaaa tcaatgcact tttgcatggc      480

gtgtttggcc tgccgcgcat tccctggctc acgagcgcgt tatgggctcg aatcgctgtc      540

atcatggtca atgtttgggc cggttttccc tacatgatga ccgtttgttt aggtgctctg      600

cagtcgatcc cgaccgacca atatgaggcc gcggaaattg acggagccaa ctggtggcaa      660

gtgtttcggt atgtgaccat gccttcggtg tggcgaatct ctttgccgct cctgataccg      720

tctttttcat acaactttaa caacttcaac gcatcgtatc tgttgactgg aggcggaccg      780

cccaattcga acaacccatt cctgggtcaa acggacattt tggcaactgc ggcctacaaa      840

atgactctta cgttcaatcg ctacgactta ggagcgacga tttccgttct gctgttcatt      900

cttgtggctc ttatcagctg ggtgcagatg cgctataccg gagcctttaa ggaggtcgat      960

gcgtga                                                                 966


<210>   15
<211>   966
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   15
atggccaccg tcatggagat gagaaggtct cacggccggg agcgcgcaaa gcggcgcatt       60

gattgggtcg cctacgggta cctctctcca gcgctcgtca ccatctgtgt tctcagcatc      120

ctacccattt tttacactat atacatctcg tttactaatt ttaatcaaat gcactttctt      180

tcttatcagt tcgtaggttt gaagaactat gaggaacttt taaatccgca tgatccgttg      240

tcgaatctat ttttgccgac attcatctgg accttggtgt acgcgctctg taccacggcg      300

ctcgcgtatc tcgtgggatt gttcctcgcc gtcctactca ataacaaaca catgcgggag      360

cgcactctct atcgaacact gctcatcgtg ccttgggcgg ttccgaacct catttcaatg      420

ctcgcatggc agggcctgtt gaacgatcag tacgggcaaa tcaatgcact tttgcatggc      480

gtgtttggcc tgccgcgcat tccctggctc acgagcgcgt tatgggctcg aatcgctgtc      540

atcatggtca atgtttgggc cggttttccc tacatgatga ccgtttgttt aggtgctctg      600

cagtcgatcc cgaccgacca atatgaggcc gcggaaattg acggagccaa ctggtggcaa      660

gtgtttcggt atgtgaccat gccttcggtg tggcgaatct ctttgccgct cctgataccg      720

tctttttcat acaactttaa caacttcaac gcatcgtatc tgttgactgg aggcggaccg      780

cccaattcga acaacccatt cctgggtcaa acggacattt tggcaactgc ggcctacaaa      840

atgactctta cgttcaatcg ctacgactta ggagcgacga tttccgttct gctgttcatt      900

cttgtggctc ttatcagctg ggtgcagatg cgctataccg gagcctttaa ggaggtcgat      960

gcgtga                                                                 966


<210>   16
<211>   966
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   16
atggccaccg tcatggagat gagaaggtct cacggccggg agcgcgcaaa gcggcgcgtg       60

gattgggtcg cctacgggta cctctctcca gcgctcgtca ccatctgtgt tctcagcatc      120

ctacccattt tttacactat atacatctcg tttactaatt ttaatcaaat gcactttctt      180

tcttatcagt tcgtaggttt gaagaactat gaggaacttt taaatccgca tgatccgttg      240

tcgaatctat ttttgccgac attcatctgg accttggtgt acgcgctctg taccacggcg      300

ctcgcgtatc tcgtgggatt gttcctcgcc gtcctactca ataacaaaca catgcgggag      360

cgcactctct atcgaacact gctcatcgtg ccttgggcgg ttccgaacct catttcaatg      420

ctcgcatggc agggcctgtt gaacgatcag tacgggcaaa tcaatgcact tttgcatggc      480

gtgtttggcc tgccgaaaat tccctggctc acgagcgcgt tatgggctcg aatcgctgtc      540

atcatggtca atgtttgggc cggttttccc tacatgatga ccgtttgttt aggtgctctg      600

cagtcgatcc cgaccgacca atatgaggcc gcggaaattg acggagccaa ctggtggcaa      660

gtgtttcggt atgtgaccat gccttcggtg tggcgaatct ctttgccgct cctgataccg      720

tctttttcat acaactttaa caacttcaac gcatcgtatc tgttgactgg aggcggaccg      780

cccaattcga acaacccatt cctgggtcaa acggacattt tggcaactgc ggcctacaaa      840

atgactctta cgttcaatcg ctacgactta ggagcgacga tttccgttct gctgttcatt      900

cttgtggctc ttatcagctg ggtgcagatg cgctataccg gagcctttaa ggaggtcgat      960

gcgtga                                                                 966


<210>   17
<211>   966
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   17
atggccaccg tcatggagat gagaaggtct cacggccggg agcgcgcaaa gcggcgcgtg       60

gattgggtcg cctacgggta cctctctcca gcgctcgtca ccatctgtgt tctcagcatc      120

ctacccattt tttacactat atacatctcg tttactaatt ttaatcaaat gcactttctt      180

tcttatcagt tcgtaggttt gaagaactat gaggaacttt taaatccgca tgatccgttg      240

tcgaatctat ttttgccgac attcatctgg accttggtgt acgcgctctg taccacggcg      300

ctcgcgtatc tcgtgggatt gttcctcgcc gtcctactca ataacaaaca catgcgggag      360

cgcactctct atcgaacact gctcatcgtg ccttgggcgg ttccgaacat tatttcaatg      420

ctcgcatggc agggcctgtt gaacgatcag tacgggcaaa tcaatgcact tttgcatggc      480

gtgtttggcc tgccgcgcat tccctggctc acgagcgcgt tatgggctcg aatcgctgtc      540

atcatggtca atgtttgggc cggttttccc tacatgatga ccgtttgttt aggtgctctg      600

cagtcgatcc cgaccgacca atatgaggcc gcggaaattg acggagccaa ctggtggcaa      660

gtgtttcggt atgtgaccat gccttcggtg tggcgaatct ctttgccgct cctgataccg      720

tctttttcat acaactttaa caacttcaac gcatcgtatc tgttgactgg aggcggaccg      780

cccaattcga acaacccatt cctgggtcaa acggacattt tggcaactgc ggcctacaaa      840

atgactctta cgttcaatcg ctacgactta ggagcgacga tttccgttct gctgttcatt      900

cttgtggctc ttatcagctg ggtgcagatg cgctataccg gagcctttaa ggaggtcgat      960

gcgtga                                                                 966


<210>   18
<211>   427
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   18
Met Ser Val Arg Arg Trp Gly Ile Val Ser Thr Gly Val Ala Ala Leu 
                5                   10                  15      

Val Leu Ala Gly Gly Ala Ile Ala Gly Cys Gly Thr Ser Asn Gly Gly 
            20                  25                  30          

Gln Asn Thr Ser Pro Ser Thr Ser Ser Ser Ser Ala Lys Gly Glu Ala 
        35                  40                  45              

Ser Ala Leu Pro Lys Gly Gln Thr Ile Thr Val Trp Ser Trp Gln Thr 
    50                  55                  60                  

Gly Pro Glu Leu Gln Asp Val Lys Gln Ile Ala Ala Gln Trp Ala Lys 
65                  70                  75                  80  

Ala His Gly Asp Lys Val Ile Val Val Asp Gln Ser Ser Asn Pro Lys 
                85                  90                  95      

Gly Phe Gln Phe Tyr Ala Thr Ala Ala Arg Thr Gly Lys Gly Pro Asp 
            100                 105                 110         

Val Val Phe Gly Met Pro His Asp Asn Asn Gly Val Phe Ala Glu Glu 
        115                 120                 125             

Gly Leu Met Ala Pro Val Pro Ser Gly Val Leu Asn Thr Gly Leu Tyr 
    130                 135                 140                 

Ala Pro Asn Thr Ile Asp Ala Ile Lys Val Asn Gly Thr Met Tyr Ser 
145                 150                 155                 160 

Val Pro Val Ser Val Gln Val Ala Ala Ile Tyr Tyr Asn Lys Lys Leu 
                165                 170                 175     

Val Pro Gln Pro Pro Gln Thr Trp Ala Glu Phe Val Lys Asp Ala Asn 
            180                 185                 190         

Ala His Gly Phe Met Tyr Asp Gln Ala Asn Leu Tyr Phe Asp Tyr Ala 
        195                 200                 205             

Ile Ile Gly Gly Tyr Gly Gly Tyr Val Phe Lys Asp Asn Asn Gly Thr 
    210                 215                 220                 

Leu Asp Pro Asn Asn Ile Gly Leu Asp Thr Pro Gly Ala Val Gln Ala 
225                 230                 235                 240 

Tyr Thr Leu Met Arg Asp Met Val Ser Lys Tyr His Trp Met Thr Pro 
                245                 250                 255     

Ser Thr Asn Gly Ser Ile Ala Lys Ala Glu Phe Leu Ala Gly Lys Ile 
            260                 265                 270         

Gly Met Tyr Val Ser Gly Pro Trp Asp Thr Ala Asp Ile Glu Lys Ala 
        275                 280                 285             

Lys Ile Asp Phe Gly Val Thr Pro Trp Pro Thr Leu Pro Asn Gly Lys 
    290                 295                 300                 

His Ala Thr Pro Phe Leu Gly Val Ile Thr Ala Phe Val Asn Lys Glu 
305                 310                 315                 320 

Ser Lys Thr Gln Ala Ala Asp Trp Ser Leu Val Gln Ala Leu Thr Ser 
                325                 330                 335     

Ala Gln Ala Gln Gln Met Tyr Phe Arg Asp Ser Gln Gln Ile Pro Ala 
            340                 345                 350         

Leu Leu Ser Val Gln Arg Ser Ser Ala Val Gln Ser Ser Pro Thr Phe 
        355                 360                 365             

Lys Ala Phe Val Glu Gln Leu Arg Tyr Ala Val Pro Met Pro Asn Ile 
    370                 375                 380                 

Pro Gln Met Gln Ala Val Trp Gln Ala Met Ser Ile Leu Gln Asn Ile 
385                 390                 395                 400 

Ile Ala Gly Lys Val Ser Pro Glu Gln Gly Ala Lys Asp Phe Val Gln 
                405                 410                 415     

Asn Ile Gln Lys Gly Ile Met Ala Gln Gly Ser 
            420                 425         

<210>   19
<211>   1284
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   19
gtgtcggtga ggagatgggg aatcgtatcg acaggtgtgg ccgcgctcgt gttggcgggc       60

ggagccatcg cgggctgtgg aacctcgaac ggtggtcaaa acacgtctcc ttccacgagc      120

tcgtcgagcg ccaaagggga ggcaagcgct ctgcccaaag ggcagaccat caccgtttgg      180

tcgtggcaga cagggccgga gttgcaagac gtgaagcaga tcgccgctca gtgggcaaag      240

gctcatgggg acaaggtcat tgtcgtcgac caaagctcca atccgaaggg attccagttc      300

tacgccacgg cggctcgcac gggcaagggg cctgatgtcg tgtttggaat gccgcacgac      360

aacaatggcg ttttcgcaga agaaggattg atggcgccgg taccgtctgg cgtgctcaac      420

acgggtctct atgcacctaa tacgatcgac gccatcaagg tcaacggcac gatgtactcg      480

gtgccagtat ccgttcaggt cgcggcaatc tactacaaca aaaagcttgt gccgcagcca      540

ccgcagacat gggccgaatt cgtgaaagac gcaaatgcac atggcttcat gtatgaccaa      600

gcgaatcttt acttcgatta cgccattatc ggcggctatg gcgggtatgt gttcaaggac      660

aacaacggca cactcgaccc gaacaacata ggtcttgaca caccgggggc tgtgcaggct      720

tacacgctga tgagggatat ggtctccaag tatcactgga tgaccccgag cacgaatggc      780

tctatcgcga aggctgagtt tctggctggg aagattggta tgtacgtgag tggcccatgg      840

gacacggcgg atattgagaa ggccaaaatt gacttcggtg taacgccatg gcccaccttg      900

ccgaacggca agcatgccac gcccttctta ggcgttatca cggcatttgt gaacaaggag      960

tccaagaccc aggcagctga ctggagcctt gttcaagcgt tgaccagtgc gcaggcgcag     1020

caaatgtact tcagagattc ccagcagatt cctgcgctct tgtctgtgca gaggtcgagc     1080

gccgtccagt cgagcccaac ctttaaagcg ttcgtcgaac agttgcgcta cgcggtaccg     1140

atgcccaaca ttccgcaaat gcaggccgtg tggcaagcaa tgagcatcct gcagaatatc     1200

attgcgggca aggtgtcacc agagcagggt gcgaaggatt ttgtgcaaaa cattcaaaaa     1260

ggcatcatgg cacaaggatc ctga                                            1284


<210>   20
<211>   427
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   20
Met Ser Val Arg Arg Trp Gly Ile Val Ser Thr Gly Val Ala Ala Leu 
                5                   10                  15      

Val Leu Ala Gly Gly Ala Ile Ala Gly Cys Gly Thr Ser Asn Gly Gly 
            20                  25                  30          

Gln Asn Thr Ser Pro Ser Thr Ser Ser Ser Ser Ala Lys Gly Glu Ala 
        35                  40                  45              

Ser Ala Leu Pro Lys Gly Gln Thr Ile Thr Val Trp Ser Trp Gln Thr 
    50                  55                  60                  

Gly Pro Glu Leu Gln Asp Val Lys Gln Ile Ala Ala Gln Trp Ala Lys 
65                  70                  75                  80  

Ala His Gly Asp Lys Val Ile Val Val Asp Gln Ser Ser Asn Pro Lys 
                85                  90                  95      

Gly Phe Gln Phe Tyr Ala Thr Ala Ala Arg Thr Gly Lys Gly Pro Asp 
            100                 105                 110         

Val Val Phe Gly Met Pro His Asp Asn Asn Gly Val Phe Ala Glu Glu 
        115                 120                 125             

Gly Leu Met Ala Pro Val Pro Ser Gly Val Leu Asn Thr Gly Leu Tyr 
    130                 135                 140                 

Ala Pro Asn Thr Ile Asp Ala Ile Lys Val Asn Gly Thr Met Tyr Ser 
145                 150                 155                 160 

Val Pro Val Ser Val Gln Val Ala Ala Ile Tyr Tyr Asn Lys Lys Leu 
                165                 170                 175     

Val Pro Gln Pro Pro Gln Thr Trp Ala Glu Phe Val Lys Asp Ala Asn 
            180                 185                 190         

Ala His Gly Phe Met Tyr Asp Gln Ala Asn Leu Tyr Phe Asp Tyr Ala 
        195                 200                 205             

Ile Ile Gly Gly Tyr Gly Gly Tyr Val Phe Lys Asp Asn Asn Gly Thr 
    210                 215                 220                 

Leu Asp Pro Asn Asn Ile Gly Leu Asp Thr Pro Gly Ala Val Gln Ala 
225                 230                 235                 240 

Tyr Thr Leu Met Arg Asp Met Val Ser Lys Tyr His Trp Met Thr Pro 
                245                 250                 255     

Ser Thr Asn Gly Ser Ile Ala Lys Ala Glu Phe Leu Ala Gly Lys Ile 
            260                 265                 270         

Gly Met Tyr Val Ser Gly Pro Trp Asp Thr Ala Asp Ile Glu Lys Ala 
        275                 280                 285             

Lys Ile Asp Phe Gly Val Thr Pro Trp Pro Thr Leu Pro Asn Gly Lys 
    290                 295                 300                 

His Ala Thr Pro Phe Leu Gly Val Ile Thr Ala Phe Val Asn Lys Glu 
305                 310                 315                 320 

Ser Lys Thr Gln Ala Ala Asp Trp Ser Leu Val Gln Ala Leu Thr Ser 
                325                 330                 335     

Ala Gln Ala Gln Gln Met Tyr Phe Arg Asp Ser Gln Gln Ile Pro Ala 
            340                 345                 350         

Leu Leu Ser Val Gln Arg Ser Ser Ala Val Gln Ser Ser Pro Thr Phe 
        355                 360                 365             

Lys Ala Phe Val Glu Gln Leu Arg Tyr Ala Val Pro Met Pro Asn Ile 
    370                 375                 380                 

Pro Gln Met Gln Ala Val Trp Gln Ala Met Ser Ile Leu Gln Asn Ile 
385                 390                 395                 400 

Ile Ala Gly Lys Val Ser Pro Glu Gln Gly Ala Lys Asp Phe Val Gln 
                405                 410                 415     

Asn Ile Gln Lys Gly Ile Met Ala Gln Gly Ser 
            420                 425         

<210>   21
<211>   384
<212>   PRT
<213>   Alicyclobacillus Acidocaldarius 

<400>   21
Ala Lys Gly Glu Ala Ser Ala Leu Pro Lys Gly Gln Thr Ile Thr Val 
                5                   10                  15      

Trp Ser Trp Gln Thr Gly Pro Glu Leu Gln Asp Val Lys Gln Ile Ala 
            20                  25                  30          

Ala Gln Trp Ala Lys Ala His Gly Asp Lys Val Ile Val Val Asp Gln 
        35                  40                  45              

Ser Ser Asn Pro Lys Gly Phe Gln Phe Tyr Ala Thr Ala Ala Arg Thr 
    50                  55                  60                  

Gly Lys Gly Pro Asp Val Val Phe Gly Met Pro His Asp Asn Asn Gly 
65                  70                  75                  80  

Val Phe Ala Glu Glu Gly Leu Met Ala Pro Val Pro Ser Gly Val Leu 
                85                  90                  95      

Asn Thr Gly Leu Tyr Ala Pro Asn Thr Ile Asp Ala Ile Lys Val Asn 
            100                 105                 110         

Gly Thr Met Tyr Ser Val Pro Val Ser Val Gln Val Ala Ala Ile Tyr 
        115                 120                 125             

Tyr Asn Lys Lys Leu Val Pro Gln Pro Pro Gln Thr Trp Ala Glu Phe 
    130                 135                 140                 

Val Lys Asp Ala Asn Ala His Gly Phe Met Tyr Asp Gln Ala Asn Leu 
145                 150                 155                 160 

Tyr Phe Asp Tyr Ala Ile Ile Gly Gly Tyr Gly Gly Tyr Val Phe Lys 
                165                 170                 175     

Asp Asn Asn Gly Thr Leu Asp Pro Asn Asn Ile Gly Leu Asp Thr Pro 
            180                 185                 190         

Gly Ala Val Gln Ala Tyr Thr Leu Met Arg Asp Met Val Ser Lys Tyr 
        195                 200                 205             

His Trp Met Thr Pro Ser Thr Asn Gly Ser Ile Ala Lys Ala Glu Phe 
    210                 215                 220                 

Leu Ala Gly Lys Ile Gly Met Tyr Val Ser Gly Pro Trp Asp Thr Ala 
225                 230                 235                 240 

Asp Ile Glu Lys Ala Lys Ile Asp Phe Gly Val Thr Pro Trp Pro Thr 
                245                 250                 255     

Leu Pro Asn Gly Lys His Ala Thr Pro Phe Leu Gly Val Ile Thr Ala 
            260                 265                 270         

Phe Val Asn Lys Glu Ser Lys Thr Gln Ala Ala Asp Trp Ser Leu Val 
        275                 280                 285             

Gln Ala Leu Thr Ser Ala Gln Ala Gln Gln Met Tyr Phe Arg Asp Ser 
    290                 295                 300                 

Gln Gln Ile Pro Ala Leu Leu Ser Val Gln Arg Ser Ser Ala Val Gln 
305                 310                 315                 320 

Ser Ser Pro Thr Phe Lys Ala Phe Val Glu Gln Leu Arg Tyr Ala Val 
                325                 330                 335     

Pro Met Pro Asn Ile Pro Gln Met Gln Ala Val Trp Gln Ala Met Ser 
            340                 345                 350         

Ile Leu Gln Asn Ile Ile Ala Gly Lys Val Ser Pro Glu Gln Gly Ala 
        355                 360                 365             

Lys Asp Phe Val Gln Asn Ile Gln Lys Gly Ile Met Ala Gln Gly Ser 
    370                 375                 380                 

<210>   22
<211>   370
<212>   PRT
<213>   Alicyclobacillus Acidocaldarius 

<400>   22
Gln Thr Ile Thr Val Trp Ser Trp Gln Thr Gly Pro Glu Leu Gln Asp 
                5                   10                  15      

Val Lys Gln Ile Ala Ala Gln Trp Ala Lys Ala His Gly Asp Lys Val 
            20                  25                  30          

Ile Val Val Asp Gln Ser Ser Asn Pro Lys Gly Phe Gln Phe Tyr Ala 
        35                  40                  45              

Thr Ala Ala Arg Thr Gly Lys Gly Pro Asp Val Val Phe Gly Met Pro 
    50                  55                  60                  

His Asp Asn Asn Gly Val Phe Ala Glu Glu Gly Leu Met Ala Pro Val 
65                  70                  75                  80  

Pro Ser Gly Val Leu Asn Thr Gly Leu Tyr Ala Pro Asn Thr Ile Asp 
                85                  90                  95      

Ala Ile Lys Val Asn Gly Thr Met Tyr Ser Val Pro Val Ser Val Gln 
            100                 105                 110         

Val Ala Ala Ile Tyr Tyr Asn Lys Lys Leu Val Pro Gln Pro Pro Gln 
        115                 120                 125             

Thr Trp Ala Glu Phe Val Lys Asp Ala Asn Ala His Gly Phe Met Tyr 
    130                 135                 140                 

Asp Gln Ala Asn Leu Tyr Phe Asp Tyr Ala Ile Ile Gly Gly Tyr Gly 
145                 150                 155                 160 

Gly Tyr Val Phe Lys Asp Asn Asn Gly Thr Leu Asp Pro Asn Asn Ile 
                165                 170                 175     

Gly Leu Asp Thr Pro Gly Ala Val Gln Ala Tyr Thr Leu Met Arg Asp 
            180                 185                 190         

Met Val Ser Lys Tyr His Trp Met Thr Pro Ser Thr Asn Gly Ser Ile 
        195                 200                 205             

Ala Lys Ala Glu Phe Leu Ala Gly Lys Ile Gly Met Tyr Val Ser Gly 
    210                 215                 220                 

Pro Trp Asp Thr Ala Asp Ile Glu Lys Ala Lys Ile Asp Phe Gly Val 
225                 230                 235                 240 

Thr Pro Trp Pro Thr Leu Pro Asn Gly Lys His Ala Thr Pro Phe Leu 
                245                 250                 255     

Gly Val Ile Thr Ala Phe Val Asn Lys Glu Ser Lys Thr Gln Ala Ala 
            260                 265                 270         

Asp Trp Ser Leu Val Gln Ala Leu Thr Ser Ala Gln Ala Gln Gln Met 
        275                 280                 285             

Tyr Phe Arg Asp Ser Gln Gln Ile Pro Ala Leu Leu Ser Val Gln Arg 
    290                 295                 300                 

Ser Ser Ala Val Gln Ser Ser Pro Thr Phe Lys Ala Phe Val Glu Gln 
305                 310                 315                 320 

Leu Arg Tyr Ala Val Pro Met Pro Asn Ile Pro Gln Met Gln Ala Val 
                325                 330                 335     

Trp Gln Ala Met Ser Ile Leu Gln Asn Ile Ile Ala Gly Lys Val Ser 
            340                 345                 350         

Pro Glu Gln Gly Ala Lys Asp Phe Val Gln Asn Ile Gln Lys Gly Ile 
        355                 360                 365             

Met Ala 
    370 

<210>   23
<211>   378
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   23
Ser Ser Gly Gln Thr Glu Gln Lys Lys Glu Pro Val Glu Leu Ile Val 
                5                   10                  15      

Trp Ser His Leu Thr Asp Pro Glu Ile Ala Lys Val Gln Glu Ile Ala 
            20                  25                  30          

Asn Lys Trp Ala Glu Gln Thr Gly Asn Lys Val Lys Val Leu Ala Asp 
        35                  40                  45              

Gln Ser Asp Phe Gln Ala Phe Ser Thr Ala Ala Gln Ser Gly Lys Gly 
    50                  55                  60                  

Pro Asp Ile Met Phe Gly Leu Pro His Asp Asn Leu Gly Thr Phe Gln 
65                  70                  75                  80  

Lys Ala Gly Leu Leu Ala Glu Val Pro Asp Gly Val Ile Asn Lys Asp 
                85                  90                  95      

Asp Tyr Val Pro Met Ser Ile Ser Ala Val Ser Tyr Asp Gly Lys Met 
            100                 105                 110         

Tyr Ala Val Pro Ile Ser Met Glu Thr Tyr Ala Leu Phe Tyr Asn Thr 
        115                 120                 125             

Asp Lys Val Pro Thr Pro Pro Ala Thr Leu Asp Asp Leu Ile Lys Leu 
    130                 135                 140                 

Gly Lys Glu Val Gly Phe Gln Tyr Asp Val Asn Asn Phe Tyr Phe Ser 
145                 150                 155                 160 

Phe Ala Phe Ile Ser Ala Tyr Gly Gly Tyr Val Phe Lys Asp Thr Gly 
                165                 170                 175     

Gly Gly Leu Asp Pro Asn Asp Ile Gly Leu Asn Asn Asp Gly Ala Lys 
            180                 185                 190         

Lys Gly Leu Glu Leu Ile Lys Asp Phe Val Thr Lys Tyr Lys Phe Met 
        195                 200                 205             

Pro Ala Asp Ile Asn Gly Asp Met Ala Lys Gly Asn Phe Gln Ser Gly 
    210                 215                 220                 

Lys Thr Gly Leu Tyr Ile Ser Gly Pro Trp Asp Val Asp Gly Phe Lys 
225                 230                 235                 240 

Lys Ala Asn Val Pro Phe Lys Val Ala Pro Leu Pro Gln Val Asp Gly 
                245                 250                 255     

Lys Pro Met Pro Ser Phe Ala Gly Val Gln Ala Ala Phe Val Ser Ala 
            260                 265                 270         

Asn Ser Lys His Gln Gln Glu Ala Trp Asp Leu Met Lys Tyr Leu Ala 
        275                 280                 285             

Glu Asn Thr Gly Leu Pro Leu Phe Glu Thr Gly Asn Arg Ile Pro Ala 
    290                 295                 300                 

Leu Lys Ser Leu Leu Asp Asn Pro Glu Val Lys Asn Asn Glu Ile Leu 
305                 310                 315                 320 

Asn Ala Phe Ala Glu Gln Ala Thr His Ala Ile Pro Met Pro Asn Ile 
                325                 330                 335     

Pro Gln Met Ala Ala Val Trp Thr Pro Ala Gly Asn Ala Leu Gln Leu 
            340                 345                 350         

Ile Thr Ser Gly Lys Val Pro Val Asp Lys Ala Ala Asp Asp Met Val 
        355                 360                 365             

Asn Gln Ile Lys Gln Gly Ile Ala Thr Gln 
    370                 375             

<210>   24
<211>   362
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   24
Leu Ile Val Trp Ser His Leu Thr Asp Pro Glu Ile Ala Lys Val Gln 
                5                   10                  15      

Glu Ile Ala Asn Lys Trp Ala Glu Gln Thr Gly Asn Lys Val Lys Val 
            20                  25                  30          

Leu Ala Asp Gln Ser Asp Phe Gln Ala Phe Ala Thr Ala Ala Gln Ser 
        35                  40                  45              

Gly Lys Gly Pro Asp Ile Met Phe Gly Leu Pro His Asp Asn Leu Gly 
    50                  55                  60                  

Thr Phe Gln Lys Ala Gly Leu Leu Ala Glu Val Pro Glu Gly Val Ile 
65                  70                  75                  80  

Asn Lys Asp Asp Tyr Val Pro Met Ser Ile Ser Ala Val Ser Tyr Asp 
                85                  90                  95      

Gly Lys Met Tyr Ala Val Pro Ile Ala Met Glu Thr Tyr Ala Leu Phe 
            100                 105                 110         

Tyr Asn Thr Asp Lys Val Lys Thr Pro Pro Ala Thr Leu Asp Asp Leu 
        115                 120                 125             

Ile Lys Leu Gly Lys Glu Val Gly Phe Gln Tyr Asp Val Asn Asn Phe 
    130                 135                 140                 

Tyr Phe Ser Phe Ala Phe Ile Ala Ala Tyr Gly Gly Tyr Val Phe Lys 
145                 150                 155                 160 

Asp Thr Gly Gly Gly Leu Asp Pro Asn Asp Ile Gly Leu Asn Asn Glu 
                165                 170                 175     

Gly Ala Lys Lys Gly Leu Glu Leu Ile Lys Asp Phe Val Gln Lys Tyr 
            180                 185                 190         

Lys Phe Met Pro Pro Asp Ile Asn Tyr Asp Met Ala Lys Gly Asn Phe 
        195                 200                 205             

Gln Ser Gly Lys Ile Gly Leu Tyr Ile Ser Gly Pro Trp Asp Val Asp 
    210                 215                 220                 

Gly Phe Lys Lys Ala Asn Val Pro Phe Lys Val Ala Pro Leu Pro Lys 
225                 230                 235                 240 

Ile Asp Gly Lys Pro Thr Pro Ser Phe Ala Gly Val Gln Ala Ala Phe 
                245                 250                 255     

Val Ser Ala Asn Ser Lys His Gln Lys Glu Ala Trp Asp Leu Met Lys 
            260                 265                 270         

Tyr Leu Val Glu Asn Thr Gly Leu Pro Leu Phe Glu Thr Gly Asn Arg 
        275                 280                 285             

Ile Pro Val Ile Lys Ser Leu Leu Asp Asn Pro Glu Val Lys Gly Asn 
    290                 295                 300                 

Glu Ile Leu Ser Ala Phe Ala Glu Gln Ala Gln His Ala Ile Pro Met 
305                 310                 315                 320 

Pro Asn Ile Pro Gln Met Ser Gln Val Trp Thr Pro Ala Gly Asn Ala 
                325                 330                 335     

Leu Gln Leu Ile Thr Ser Gly Lys Val Pro Val Asp Lys Ala Ala Asp 
            340                 345                 350         

Asp Met Val Lys Gln Ile Lys Gln Gly Ile 
        355                 360         

<210>   25
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   25
Met Ser Val Arg Arg Trp Gly Ile Val Ser Thr Gly Val Ala Ala Leu 
                5                   10                  15      

Val Leu Ala Gly Gly Ala Ile Ala Gly Cys Gly Thr Ser Asn Gly Gly 
            20                  25                  30          

Gln Asn Thr Ser Pro Ser Thr Ser Ser Ser Ser Ala Lys Gly Glu Ala 
        35                  40                  45              

Ser Ala Leu Pro Lys Gly Gln Thr Ile Thr Val Trp Ser Trp Gln Thr 
    50                  55                  60                  

Gly Pro Glu Leu Gln Asp Val Lys Gln Ile Ala Ala Gln Trp Ala Lys 
65                  70                  75                  80  

Ala His Gly Asp Lys Val Ile Val Val Asp Gln Ser Ser Asn Pro Lys 
                85                  90                  95      

Gly Phe Gln Phe Tyr Ala Thr Ala Ala Arg Thr Gly Lys Gly Pro Asp 
            100                 105                 110         

Val Val Phe Gly Met Pro His Asp Asn Asn Gly Val Phe Ala Glu Glu 
        115                 120                 125             

Gly Leu Met Ala Pro Val Pro Ser Gly Val Leu Asn Thr Gly Leu Tyr 
    130                 135                 140                 

Ala Pro Asn Thr Ile Asp Ala Ile Lys Val Asn Gly Thr Met Tyr Ser 
145                 150                 155                 160 

Val Pro Val Ser Val Gln Val Ala Ala Ile Tyr Tyr Asn Lys Lys Leu 
                165                 170                 175     

Val Pro Gln Pro Pro Gln Thr Trp Ala Glu Phe Val Lys Asp Ala Asn 
            180                 185                 190         

Ala His Gly Phe Met Tyr Asp Gln Ala Asn Leu Tyr Phe Asp Tyr Ala 
        195                 200                 205             

Ile Ile Gly Gly Tyr Gly Gly Tyr Val Phe Lys Asp Asn Asn Gly Thr 
    210                 215                 220                 

Leu Asp Pro Asn Asn Ile Gly Leu Asp Thr Pro Gly Ala Val Gln Ala 
225                 230                 235                 240 

Tyr Thr Leu Met Arg Asp Met Val Ser Lys Tyr His Trp Met Thr Pro 
                245                 250                 255     

Ser Thr Asn Gly Ser Ile Ala Lys Ala Glu Phe Leu Ala Gly Lys Ile 
            260                 265                 270         

Gly Met Tyr Val Ser Gly Pro Trp Asp Thr Ala Asp Ile Glu Lys Ala 
        275                 280                 285             

Lys Ile Asp Phe Gly Val Thr Pro Trp Pro Thr Leu Pro Asn Gly Lys 
    290                 295                 300                 

His Ala Thr Pro Phe Leu Gly Val Ile Thr Ala Phe Val Asn Lys Glu 
305                 310                 315                 320 

Ser Lys Thr Gln Ala Ala Asp Trp Ser Leu Val Gln Ala Leu Thr Ser 
                325                 330                 335     

Ala Gln Ala Gln Gln Met Tyr Phe Arg Asp Ser Gln Gln Ile Pro Ala 
            340                 345                 350         

Leu Leu Ser Val Gln Arg Ser Ser Ala Val Gln Ser Ser Pro Thr Phe 
        355                 360                 365             

Lys Ala Phe Val Glu Gln Leu Lys Tyr Ala Val Pro Met Pro Asn Ile 
    370                 375                 380                 

Pro Gln Met Gln Ala Val Trp Gln Ala Met Ser Ile Leu Gln Asn Ile 
385                 390                 395                 400 

Ile Ala Gly Lys Val Ser Pro Glu Gln Gly Ala Lys Asp Phe Val Gln 
                405                 410                 415     

Asn Ile Gln Lys Gly Ile Met Ala Gln Gly Ser 
            420                 425         

<210>   26
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   26
Met Ser Val Arg Arg Trp Gly Ile Val Ser Thr Gly Val Ala Ala Leu 
                5                   10                  15      

Val Leu Ala Gly Gly Ala Ile Ala Gly Cys Gly Thr Ser Asn Gly Gly 
            20                  25                  30          

Gln Asn Thr Ser Pro Ser Thr Ser Ser Ser Ser Ala Lys Gly Glu Ala 
        35                  40                  45              

Ser Ala Leu Pro Lys Gly Gln Thr Ile Thr Val Trp Ser Trp Gln Thr 
    50                  55                  60                  

Gly Pro Glu Leu Gln Asp Val Lys Gln Ile Ala Ala Gln Trp Ala Lys 
65                  70                  75                  80  

Ala His Gly Asp Lys Val Ile Val Val Asp Gln Ser Ser Asn Pro Lys 
                85                  90                  95      

Gly Phe Gln Phe Tyr Ala Thr Ala Ala Arg Thr Gly Lys Gly Pro Asp 
            100                 105                 110         

Val Val Phe Gly Met Pro His Asp Asn Asn Gly Val Phe Ala Asp Glu 
        115                 120                 125             

Gly Leu Met Ala Pro Val Pro Ser Gly Val Leu Asn Thr Gly Leu Tyr 
    130                 135                 140                 

Ala Pro Asn Thr Ile Asp Ala Ile Lys Val Asn Gly Thr Met Tyr Ser 
145                 150                 155                 160 

Val Pro Val Ser Val Gln Val Ala Ala Ile Tyr Tyr Asn Lys Lys Leu 
                165                 170                 175     

Val Pro Gln Pro Pro Gln Thr Trp Ala Glu Phe Val Lys Asp Ala Asn 
            180                 185                 190         

Ala His Gly Phe Met Tyr Asp Gln Ala Asn Leu Tyr Phe Asp Tyr Ala 
        195                 200                 205             

Ile Ile Gly Gly Tyr Gly Gly Tyr Val Phe Lys Asp Asn Asn Gly Thr 
    210                 215                 220                 

Leu Asp Pro Asn Asn Ile Gly Leu Asp Thr Pro Gly Ala Val Gln Ala 
225                 230                 235                 240 

Tyr Thr Leu Met Arg Asp Met Val Ser Lys Tyr His Trp Met Thr Pro 
                245                 250                 255     

Ser Thr Asn Gly Ser Ile Ala Lys Ala Glu Phe Leu Ala Gly Lys Ile 
            260                 265                 270         

Gly Met Tyr Val Ser Gly Pro Trp Asp Thr Ala Asp Ile Glu Lys Ala 
        275                 280                 285             

Lys Ile Asp Phe Gly Val Thr Pro Trp Pro Thr Leu Pro Asn Gly Lys 
    290                 295                 300                 

His Ala Thr Pro Phe Leu Gly Val Ile Thr Ala Phe Val Asn Lys Glu 
305                 310                 315                 320 

Ser Lys Thr Gln Ala Ala Asp Trp Ser Leu Val Gln Ala Leu Thr Ser 
                325                 330                 335     

Ala Gln Ala Gln Gln Met Tyr Phe Arg Asp Ser Gln Gln Ile Pro Ala 
            340                 345                 350         

Leu Leu Ser Val Gln Arg Ser Ser Ala Val Gln Ser Ser Pro Thr Phe 
        355                 360                 365             

Lys Ala Phe Val Glu Gln Leu Arg Tyr Ala Val Pro Met Pro Asn Ile 
    370                 375                 380                 

Pro Gln Met Gln Ala Val Trp Gln Ala Met Ser Ile Leu Gln Asn Ile 
385                 390                 395                 400 

Ile Ala Gly Lys Val Ser Pro Glu Gln Gly Ala Lys Asp Phe Val Gln 
                405                 410                 415     

Asn Ile Gln Lys Gly Ile Met Ala Gln Gly Ser 
            420                 425         

<210>   27
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   27
Met Ser Val Arg Arg Trp Gly Ile Val Ser Thr Gly Val Ala Ala Leu 
                5                   10                  15      

Val Leu Ala Gly Gly Ala Ile Ala Gly Cys Gly Thr Ser Asn Gly Gly 
            20                  25                  30          

Gln Asn Thr Ser Pro Ser Thr Ser Ser Ser Ser Ala Lys Gly Glu Ala 
        35                  40                  45              

Ser Ala Leu Pro Lys Gly Gln Thr Ile Thr Val Trp Ser Trp Gln Thr 
    50                  55                  60                  

Gly Pro Glu Leu Gln Asp Val Lys Gln Ile Ala Ala Gln Trp Ala Lys 
65                  70                  75                  80  

Ala His Gly Asp Lys Val Ile Val Val Asp Gln Ser Ser Asn Pro Lys 
                85                  90                  95      

Gly Phe Gln Phe Tyr Ala Thr Ala Ala Arg Thr Gly Lys Gly Pro Asp 
            100                 105                 110         

Val Val Phe Gly Met Pro His Asp Asn Asn Gly Val Phe Ala Glu Glu 
        115                 120                 125             

Gly Leu Met Ala Pro Val Pro Ser Gly Val Leu Asn Thr Gly Leu Tyr 
    130                 135                 140                 

Ala Pro Asn Thr Ile Asp Ala Ile Lys Val Asn Gly Thr Met Tyr Ser 
145                 150                 155                 160 

Val Pro Val Ser Val Gln Val Ala Ala Ile Tyr Tyr Asn Lys Lys Leu 
                165                 170                 175     

Val Pro Gln Pro Pro Gln Thr Trp Ala Glu Phe Val Lys Asp Ala Asn 
            180                 185                 190         

Ala His Gly Phe Met Tyr Asp Gln Ala Asn Leu Tyr Phe Glu Tyr Ala 
        195                 200                 205             

Ile Ile Gly Gly Tyr Gly Gly Tyr Val Phe Lys Asp Asn Asn Gly Thr 
    210                 215                 220                 

Leu Asp Pro Asn Asn Ile Gly Leu Asp Thr Pro Gly Ala Val Gln Ala 
225                 230                 235                 240 

Tyr Thr Leu Met Arg Asp Met Val Ser Lys Tyr His Trp Met Thr Pro 
                245                 250                 255     

Ser Thr Asn Gly Ser Ile Ala Lys Ala Glu Phe Leu Ala Gly Lys Ile 
            260                 265                 270         

Gly Met Tyr Val Ser Gly Pro Trp Asp Thr Ala Asp Ile Glu Lys Ala 
        275                 280                 285             

Lys Ile Asp Phe Gly Val Thr Pro Trp Pro Thr Leu Pro Asn Gly Lys 
    290                 295                 300                 

His Ala Thr Pro Phe Leu Gly Val Ile Thr Ala Phe Val Asn Lys Glu 
305                 310                 315                 320 

Ser Lys Thr Gln Ala Ala Asp Trp Ser Leu Val Gln Ala Leu Thr Ser 
                325                 330                 335     

Ala Gln Ala Gln Gln Met Tyr Phe Arg Asp Ser Gln Gln Ile Pro Ala 
            340                 345                 350         

Leu Leu Ser Val Gln Arg Ser Ser Ala Val Gln Ser Ser Pro Thr Phe 
        355                 360                 365             

Lys Ala Phe Val Glu Gln Leu Arg Tyr Ala Val Pro Met Pro Asn Ile 
    370                 375                 380                 

Pro Gln Met Gln Ala Val Trp Gln Ala Met Ser Ile Leu Gln Asn Ile 
385                 390                 395                 400 

Ile Ala Gly Lys Val Ser Pro Glu Gln Gly Ala Lys Asp Phe Val Gln 
                405                 410                 415     

Asn Ile Gln Lys Gly Ile Met Ala Gln Gly Ser 
            420                 425         

<210>   28
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   28
Met Ser Val Arg Arg Trp Gly Ile Val Ser Thr Gly Val Ala Ala Leu 
                5                   10                  15      

Val Leu Ala Gly Gly Ala Ile Ala Gly Cys Gly Thr Ser Asn Gly Gly 
            20                  25                  30          

Gln Asn Thr Ser Pro Ser Thr Ser Ser Ser Ser Ala Lys Gly Glu Ala 
        35                  40                  45              

Ser Ala Leu Pro Lys Gly Gln Thr Ile Thr Val Trp Ser Trp Gln Thr 
    50                  55                  60                  

Gly Pro Glu Leu Gln Asp Val Lys Gln Ile Ala Ala Gln Trp Ala Lys 
65                  70                  75                  80  

Ala His Gly Asp Lys Val Ile Val Val Asp Gln Ser Ser Asn Pro Lys 
                85                  90                  95      

Gly Phe Gln Phe Tyr Ala Thr Ala Ala Arg Thr Gly Lys Gly Pro Asp 
            100                 105                 110         

Val Val Phe Gly Met Pro His Asp Asn Asn Gly Val Phe Ala Glu Glu 
        115                 120                 125             

Gly Leu Met Ala Pro Val Pro Ser Gly Val Leu Asn Thr Gly Leu Tyr 
    130                 135                 140                 

Ala Pro Asn Thr Ile Asp Ala Ile Lys Val Asn Gly Thr Met Tyr Ser 
145                 150                 155                 160 

Val Pro Val Ser Val Gln Val Ala Ala Ile Tyr Tyr Asn Lys Lys Leu 
                165                 170                 175     

Val Pro Gln Pro Pro Gln Thr Trp Ala Glu Phe Val Lys Asp Ala Asn 
            180                 185                 190         

Ala His Gly Phe Met Tyr Asp Gln Ala Asn Leu Tyr Phe Asp Tyr Ala 
        195                 200                 205             

Ile Ile Gly Gly Tyr Gly Gly Tyr Val Phe Lys Asp Gln Asn Gly Thr 
    210                 215                 220                 

Leu Asp Pro Asn Asn Ile Gly Leu Asp Thr Pro Gly Ala Val Gln Ala 
225                 230                 235                 240 

Tyr Thr Leu Met Arg Asp Met Val Ser Lys Tyr His Trp Met Thr Pro 
                245                 250                 255     

Ser Thr Asn Gly Ser Ile Ala Lys Ala Glu Phe Leu Ala Gly Lys Ile 
            260                 265                 270         

Gly Met Tyr Val Ser Gly Pro Trp Asp Thr Ala Asp Ile Glu Lys Ala 
        275                 280                 285             

Lys Ile Asp Phe Gly Val Thr Pro Trp Pro Thr Leu Pro Asn Gly Lys 
    290                 295                 300                 

His Ala Thr Pro Phe Leu Gly Val Ile Thr Ala Phe Val Asn Lys Glu 
305                 310                 315                 320 

Ser Lys Thr Gln Ala Ala Asp Trp Ser Leu Val Gln Ala Leu Thr Ser 
                325                 330                 335     

Ala Gln Ala Gln Gln Met Tyr Phe Arg Asp Ser Gln Gln Ile Pro Ala 
            340                 345                 350         

Leu Leu Ser Val Gln Arg Ser Ser Ala Val Gln Ser Ser Pro Thr Phe 
        355                 360                 365             

Lys Ala Phe Val Glu Gln Leu Arg Tyr Ala Val Pro Met Pro Asn Ile 
    370                 375                 380                 

Pro Gln Met Gln Ala Val Trp Gln Ala Met Ser Ile Leu Gln Asn Ile 
385                 390                 395                 400 

Ile Ala Gly Lys Val Ser Pro Glu Gln Gly Ala Lys Asp Phe Val Gln 
                405                 410                 415     

Asn Ile Gln Lys Gly Ile Met Ala Gln Gly Ser 
            420                 425         

<210>   29
<211>   427
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   29
Met Ser Val Arg Arg Trp Gly Ile Ile Ser Thr Gly Val Ala Ala Leu 
                5                   10                  15      

Val Leu Ala Gly Gly Ala Ile Ala Gly Cys Gly Thr Ser Asn Gly Gly 
            20                  25                  30          

Gln Asn Thr Ser Pro Ser Thr Ser Ser Ser Ser Ala Lys Gly Glu Ala 
        35                  40                  45              

Ser Ala Leu Pro Lys Gly Gln Thr Ile Thr Val Trp Ser Trp Gln Thr 
    50                  55                  60                  

Gly Pro Glu Leu Gln Asp Val Lys Gln Ile Ala Ala Gln Trp Ala Lys 
65                  70                  75                  80  

Ala His Gly Asp Lys Val Ile Val Val Asp Gln Ser Ser Asn Pro Lys 
                85                  90                  95      

Gly Phe Gln Phe Tyr Ala Thr Ala Ala Arg Thr Gly Lys Gly Pro Asp 
            100                 105                 110         

Val Val Phe Gly Met Pro His Asp Asn Asn Gly Val Phe Ala Glu Glu 
        115                 120                 125             

Gly Leu Met Ala Pro Val Pro Ser Gly Val Leu Asn Thr Gly Leu Tyr 
    130                 135                 140                 

Ala Pro Asn Thr Ile Asp Ala Ile Lys Val Asn Gly Thr Met Tyr Ser 
145                 150                 155                 160 

Val Pro Val Ser Val Gln Val Ala Ala Ile Tyr Tyr Asn Lys Lys Leu 
                165                 170                 175     

Val Pro Gln Pro Pro Gln Thr Trp Ala Glu Phe Val Lys Asp Ala Asn 
            180                 185                 190         

Ala His Gly Phe Met Tyr Asp Gln Ala Asn Leu Tyr Phe Asp Tyr Ala 
        195                 200                 205             

Ile Ile Gly Gly Tyr Gly Gly Tyr Val Phe Lys Asp Asn Asn Gly Thr 
    210                 215                 220                 

Leu Asp Pro Asn Asn Ile Gly Leu Asp Thr Pro Gly Ala Val Gln Ala 
225                 230                 235                 240 

Tyr Thr Leu Met Arg Asp Met Val Ser Lys Tyr His Trp Met Thr Pro 
                245                 250                 255     

Ser Thr Asn Gly Ser Ile Ala Lys Ala Glu Phe Leu Ala Gly Lys Ile 
            260                 265                 270         

Gly Met Tyr Val Ser Gly Pro Trp Asp Thr Ala Asp Ile Glu Lys Ala 
        275                 280                 285             

Lys Ile Asp Phe Gly Val Thr Pro Trp Pro Thr Leu Pro Asn Gly Lys 
    290                 295                 300                 

His Ala Thr Pro Phe Leu Gly Val Ile Thr Ala Phe Val Asn Lys Glu 
305                 310                 315                 320 

Ser Lys Thr Gln Ala Ala Asp Trp Ser Leu Val Gln Ala Leu Thr Ser 
                325                 330                 335     

Ala Gln Ala Gln Gln Met Tyr Phe Arg Asp Ser Gln Gln Ile Pro Ala 
            340                 345                 350         

Leu Leu Ser Val Gln Arg Ser Ser Ala Val Gln Ser Ser Pro Thr Phe 
        355                 360                 365             

Lys Ala Phe Val Glu Gln Leu Arg Tyr Ala Val Pro Met Pro Asn Ile 
    370                 375                 380                 

Pro Gln Met Gln Ala Val Trp Gln Ala Met Ser Ile Leu Gln Asn Ile 
385                 390                 395                 400 

Ile Ala Gly Lys Val Ser Pro Glu Gln Gly Ala Lys Asp Phe Val Gln 
                405                 410                 415     

Asn Ile Gln Lys Gly Ile Met Ala Gln Gly Ser 
            420                 425         

<210>   30
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   30
gtgtcggtga ggagatgggg aatcgtatcg acaggtgtgg ccgcgctcgt gttggcgggc       60

ggagccatcg cgggctgtgg aacctcgaac ggtggtcaaa acacgtctcc ttccacgagc      120

tcgtcgagcg ccaaagggga ggcaagcgct ctgcccaaag ggcagaccat caccgtttgg      180

tcgtggcaga cagggccgga gttgcaagac gtgaagcaga tcgccgctca gtgggcaaag      240

gctcatgggg acaaggtcat tgtcgtcgac caaagctcca atccgaaggg attccagttc      300

tacgccacgg cggctcgcac gggcaagggg cctgatgtcg tgtttggaat gccgcacgac      360

aacaatggcg ttttcgcaga agaaggattg atggcgccgg taccgtctgg cgtgctcaac      420

acgggtctct atgcacctaa tacgatcgac gccatcaagg tcaacggcac gatgtactcg      480

gtgccagtat ccgttcaggt cgcggcaatc tactacaaca aaaagcttgt gccgcagcca      540

ccgcagacat gggccgaatt cgtgaaagac gcaaatgcac atggcttcat gtatgaccaa      600

gcgaatcttt acttcgatta cgccattatc ggcggctatg gcgggtatgt gttcaaggac      660

aacaacggca cactcgaccc gaacaacata ggtcttgaca caccgggggc tgtgcaggct      720

tacacgctga tgagggatat ggtctccaag tatcactgga tgaccccgag cacgaatggc      780

tctatcgcga aggctgagtt tctggctggg aagattggta tgtacgtgag tggcccatgg      840

gacacggcgg atattgagaa ggccaaaatt gacttcggtg taacgccatg gcccaccttg      900

ccgaacggca agcatgccac gcccttctta ggcgttatca cggcatttgt gaacaaggag      960

tccaagaccc aggcagctga ctggagcctt gttcaagcgt tgaccagtgc gcaggcgcag     1020

caaatgtact tcagagattc ccagcagatt cctgcgctct tgtctgtgca gaggtcgagc     1080

gccgtccagt cgagcccaac ctttaaagcg ttcgtcgaac agttgaaata cgcggtaccg     1140

atgcccaaca ttccgcaaat gcaggccgtg tggcaagcaa tgagcatcct gcagaatatc     1200

attgcgggca aggtgtcacc agagcagggt gcgaaggatt ttgtgcaaaa cattcaaaaa     1260

ggcatcatgg cacaaggatc ctga                                            1284


<210>   31
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   31
gtgtcggtga ggagatgggg aatcgtatcg acaggtgtgg ccgcgctcgt gttggcgggc       60

ggagccatcg cgggctgtgg aacctcgaac ggtggtcaaa acacgtctcc ttccacgagc      120

tcgtcgagcg ccaaagggga ggcaagcgct ctgcccaaag ggcagaccat caccgtttgg      180

tcgtggcaga cagggccgga gttgcaagac gtgaagcaga tcgccgctca gtgggcaaag      240

gctcatgggg acaaggtcat tgtcgtcgac caaagctcca atccgaaggg attccagttc      300

tacgccacgg cggctcgcac gggcaagggg cctgatgtcg tgtttggaat gccgcacgac      360

aacaatggcg ttttcgcaga tgaaggattg atggcgccgg taccgtctgg cgtgctcaac      420

acgggtctct atgcacctaa tacgatcgac gccatcaagg tcaacggcac gatgtactcg      480

gtgccagtat ccgttcaggt cgcggcaatc tactacaaca aaaagcttgt gccgcagcca      540

ccgcagacat gggccgaatt cgtgaaagac gcaaatgcac atggcttcat gtatgaccaa      600

gcgaatcttt acttcgatta cgccattatc ggcggctatg gcgggtatgt gttcaaggac      660

aacaacggca cactcgaccc gaacaacata ggtcttgaca caccgggggc tgtgcaggct      720

tacacgctga tgagggatat ggtctccaag tatcactgga tgaccccgag cacgaatggc      780

tctatcgcga aggctgagtt tctggctggg aagattggta tgtacgtgag tggcccatgg      840

gacacggcgg atattgagaa ggccaaaatt gacttcggtg taacgccatg gcccaccttg      900

ccgaacggca agcatgccac gcccttctta ggcgttatca cggcatttgt gaacaaggag      960

tccaagaccc aggcagctga ctggagcctt gttcaagcgt tgaccagtgc gcaggcgcag     1020

caaatgtact tcagagattc ccagcagatt cctgcgctct tgtctgtgca gaggtcgagc     1080

gccgtccagt cgagcccaac ctttaaagcg ttcgtcgaac agttgcgcta cgcggtaccg     1140

atgcccaaca ttccgcaaat gcaggccgtg tggcaagcaa tgagcatcct gcagaatatc     1200

attgcgggca aggtgtcacc agagcagggt gcgaaggatt ttgtgcaaaa cattcaaaaa     1260

ggcatcatgg cacaaggatc ctga                                            1284


<210>   32
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   32
gtgtcggtga ggagatgggg aatcgtatcg acaggtgtgg ccgcgctcgt gttggcgggc       60

ggagccatcg cgggctgtgg aacctcgaac ggtggtcaaa acacgtctcc ttccacgagc      120

tcgtcgagcg ccaaagggga ggcaagcgct ctgcccaaag ggcagaccat caccgtttgg      180

tcgtggcaga cagggccgga gttgcaagac gtgaagcaga tcgccgctca gtgggcaaag      240

gctcatgggg acaaggtcat tgtcgtcgac caaagctcca atccgaaggg attccagttc      300

tacgccacgg cggctcgcac gggcaagggg cctgatgtcg tgtttggaat gccgcacgac      360

aacaatggcg ttttcgcaga agaaggattg atggcgccgg taccgtctgg cgtgctcaac      420

acgggtctct atgcacctaa tacgatcgac gccatcaagg tcaacggcac gatgtactcg      480

gtgccagtat ccgttcaggt cgcggcaatc tactacaaca aaaagcttgt gccgcagcca      540

ccgcagacat gggccgaatt cgtgaaagac gcaaatgcac atggcttcat gtatgaccaa      600

gcgaatcttt acttcgaata cgccattatc ggcggctatg gcgggtatgt gttcaaggac      660

aacaacggca cactcgaccc gaacaacata ggtcttgaca caccgggggc tgtgcaggct      720

tacacgctga tgagggatat ggtctccaag tatcactgga tgaccccgag cacgaatggc      780

tctatcgcga aggctgagtt tctggctggg aagattggta tgtacgtgag tggcccatgg      840

gacacggcgg atattgagaa ggccaaaatt gacttcggtg taacgccatg gcccaccttg      900

ccgaacggca agcatgccac gcccttctta ggcgttatca cggcatttgt gaacaaggag      960

tccaagaccc aggcagctga ctggagcctt gttcaagcgt tgaccagtgc gcaggcgcag     1020

caaatgtact tcagagattc ccagcagatt cctgcgctct tgtctgtgca gaggtcgagc     1080

gccgtccagt cgagcccaac ctttaaagcg ttcgtcgaac agttgcgcta cgcggtaccg     1140

atgcccaaca ttccgcaaat gcaggccgtg tggcaagcaa tgagcatcct gcagaatatc     1200

attgcgggca aggtgtcacc agagcagggt gcgaaggatt ttgtgcaaaa cattcaaaaa     1260

ggcatcatgg cacaaggatc ctga                                            1284


<210>   33
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   33
gtgtcggtga ggagatgggg aatcgtatcg acaggtgtgg ccgcgctcgt gttggcgggc       60

ggagccatcg cgggctgtgg aacctcgaac ggtggtcaaa acacgtctcc ttccacgagc      120

tcgtcgagcg ccaaagggga ggcaagcgct ctgcccaaag ggcagaccat caccgtttgg      180

tcgtggcaga cagggccgga gttgcaagac gtgaagcaga tcgccgctca gtgggcaaag      240

gctcatgggg acaaggtcat tgtcgtcgac caaagctcca atccgaaggg attccagttc      300

tacgccacgg cggctcgcac gggcaagggg cctgatgtcg tgtttggaat gccgcacgac      360

aacaatggcg ttttcgcaga agaaggattg atggcgccgg taccgtctgg cgtgctcaac      420

acgggtctct atgcacctaa tacgatcgac gccatcaagg tcaacggcac gatgtactcg      480

gtgccagtat ccgttcaggt cgcggcaatc tactacaaca aaaagcttgt gccgcagcca      540

ccgcagacat gggccgaatt cgtgaaagac gcaaatgcac atggcttcat gtatgaccaa      600

gcgaatcttt acttcgatta cgccattatc ggcggctatg gcgggtatgt gttcaaggac      660

caaaacggca cactcgaccc gaacaacata ggtcttgaca caccgggggc tgtgcaggct      720

tacacgctga tgagggatat ggtctccaag tatcactgga tgaccccgag cacgaatggc      780

tctatcgcga aggctgagtt tctggctggg aagattggta tgtacgtgag tggcccatgg      840

gacacggcgg atattgagaa ggccaaaatt gacttcggtg taacgccatg gcccaccttg      900

ccgaacggca agcatgccac gcccttctta ggcgttatca cggcatttgt gaacaaggag      960

tccaagaccc aggcagctga ctggagcctt gttcaagcgt tgaccagtgc gcaggcgcag     1020

caaatgtact tcagagattc ccagcagatt cctgcgctct tgtctgtgca gaggtcgagc     1080

gccgtccagt cgagcccaac ctttaaagcg ttcgtcgaac agttgcgcta cgcggtaccg     1140

atgcccaaca ttccgcaaat gcaggccgtg tggcaagcaa tgagcatcct gcagaatatc     1200

attgcgggca aggtgtcacc agagcagggt gcgaaggatt ttgtgcaaaa cattcaaaaa     1260

ggcatcatgg cacaaggatc ctga                                            1284


<210>   34
<211>   1284
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   34
gtgtcggtga ggagatgggg aatcatttcg acaggtgtgg ccgcgctcgt gttggcgggc       60

ggagccatcg cgggctgtgg aacctcgaac ggtggtcaaa acacgtctcc ttccacgagc      120

tcgtcgagcg ccaaagggga ggcaagcgct ctgcccaaag ggcagaccat caccgtttgg      180

tcgtggcaga cagggccgga gttgcaagac gtgaagcaga tcgccgctca gtgggcaaag      240

gctcatgggg acaaggtcat tgtcgtcgac caaagctcca atccgaaggg attccagttc      300

tacgccacgg cggctcgcac gggcaagggg cctgatgtcg tgtttggaat gccgcacgac      360

aacaatggcg ttttcgcaga agaaggattg atggcgccgg taccgtctgg cgtgctcaac      420

acgggtctct atgcacctaa tacgatcgac gccatcaagg tcaacggcac gatgtactcg      480

gtgccagtat ccgttcaggt cgcggcaatc tactacaaca aaaagcttgt gccgcagcca      540

ccgcagacat gggccgaatt cgtgaaagac gcaaatgcac atggcttcat gtatgaccaa      600

gcgaatcttt acttcgatta cgccattatc ggcggctatg gcgggtatgt gttcaaggac      660

aacaacggca cactcgaccc gaacaacata ggtcttgaca caccgggggc tgtgcaggct      720

tacacgctga tgagggatat ggtctccaag tatcactgga tgaccccgag cacgaatggc      780

tctatcgcga aggctgagtt tctggctggg aagattggta tgtacgtgag tggcccatgg      840

gacacggcgg atattgagaa ggccaaaatt gacttcggtg taacgccatg gcccaccttg      900

ccgaacggca agcatgccac gcccttctta ggcgttatca cggcatttgt gaacaaggag      960

tccaagaccc aggcagctga ctggagcctt gttcaagcgt tgaccagtgc gcaggcgcag     1020

caaatgtact tcagagattc ccagcagatt cctgcgctct tgtctgtgca gaggtcgagc     1080

gccgtccagt cgagcccaac ctttaaagcg ttcgtcgaac agttgcgcta cgcggtaccg     1140

atgcccaaca ttccgcaaat gcaggccgtg tggcaagcaa tgagcatcct gcagaatatc     1200

attgcgggca aggtgtcacc agagcagggt gcgaaggatt ttgtgcaaaa cattcaaaaa     1260

ggcatcatgg cacaaggatc ctga                                            1284


<210>   35
<211>   488
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   35
Met Ala Asp Val Val Pro Thr Pro Trp Arg Arg Phe Ala Met Ser Thr 
                5                   10                  15      

Gln Gln Thr Gln Gly Ser Arg Ala Tyr Ala Val Thr Ile Ser Leu Ala 
            20                  25                  30          

Ala Ala Met Gly Gly Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser 
        35                  40                  45              

Gly Ala Ile Gly Phe Leu Lys Thr Leu Tyr His Leu Ser Pro Phe Met 
    50                  55                  60                  

Gln Gly Leu Val Ile Ser Ser Ile Met Ile Gly Gly Val Ile Gly Val 
65                  70                  75                  80  

Ala Val Ser Gly Phe Leu Ser Asp Arg Val Gly Arg Arg Lys Val Leu 
                85                  90                  95      

Met Thr Ala Ala Val Leu Phe Ala Val Ala Ala Phe Val Ser Ala Ile 
            100                 105                 110         

Ser Ser Asp Val Thr Thr Leu Ile Leu Ala Arg Ile Val Gly Gly Leu 
        115                 120                 125             

Gly Ile Gly Met Gly Ser Ala Leu Ser Val Thr Tyr Ile Ser Glu Cys 
    130                 135                 140                 

Ala Pro Thr Gln Ile Arg Gly Ala Leu Ser Ser Leu Tyr Gln Leu Leu 
145                 150                 155                 160 

Thr Ile Ile Gly Ile Phe Leu Thr Tyr Leu Thr Asn Tyr Leu Ile Gln 
                165                 170                 175     

Arg Ser Gly Ser Val Ala Trp Asp Val His Thr Gly Trp Arg Trp Met 
            180                 185                 190         

Leu Gly Leu Gly Cys Val Pro Ala Ala Ile Phe Phe Phe Val Leu Leu 
        195                 200                 205             

Phe Ala Pro Glu Ser Pro Arg Trp Leu Ala Lys Val Gly Arg Ile Asp 
    210                 215                 220                 

Glu Ala Leu Arg Ile Leu Val Arg Ile Asn Gly Pro Ser Ala Gly Gln 
225                 230                 235                 240 

Arg Glu Leu Glu Ser Ile Arg Glu Ser Ile Ala Ser Glu Ser Ala Ala 
                245                 250                 255     

Ser Ile Arg Asp Leu Leu Lys Pro Gly Trp Arg Lys Ala Leu Gly Val 
            260                 265                 270         

Gly Ile Leu Leu Ala Leu Phe Asn Gln Ile Ile Gly Met Asn Ala Val 
        275                 280                 285             

Thr Tyr Tyr Gly Pro Glu Ile Phe Arg Met Val Gly Phe Ser Leu Asn 
    290                 295                 300                 

Ser Asp Phe Glu Ile Gln Ala Phe Phe Gly Ala Met Trp Val Val Phe 
305                 310                 315                 320 

Thr Val Val Ala Val Val Leu Ile Asp Arg Val Gly Arg Lys Pro Leu 
                325                 330                 335     

Met Ile Val Gly Ser Ala Leu Met Ala Ile Phe Met Ala Leu Met Gly 
            340                 345                 350         

Leu Thr Phe Tyr Leu His Val His Asn Gly Phe Trp Leu Val Leu Phe 
        355                 360                 365             

Ile Met Gly Phe Thr Ala Ala Phe Ser Val Ser Met Gly Pro Ile Pro 
    370                 375                 380                 

Trp Ile Met Ile Pro Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala 
385                 390                 395                 400 

Ala Gly Val Ala Thr Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly 
                405                 410                 415     

Gln Phe Thr Pro Val Leu Leu Asn Asp Phe Gly Gly Ala Tyr Thr Phe 
            420                 425                 430         

Trp Met Phe Ala Val Ile Asn Ile Leu Gly Val Leu Phe Val Thr Ala 
        435                 440                 445             

Trp Val Pro Glu Thr Lys Asn Arg Ser Leu Glu Glu Ile Glu Ser Ile 
    450                 455                 460                 

Trp Met Ala Ser Gly Arg Gly Val Ser Leu Ser Gln Arg Asp Ala His 
465                 470                 475                 480 

Glu Arg Ala Lys Arg Ala His Phe 
                485             

<210>   36
<211>   1467
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   36
atggccgacg tcgtgcccac accttggagg aggttcgcca tgtccactca gcagacacaa       60

ggctctcgcg cctacgcggt gaccatctcg ctggcggcag cgatgggagg gctgctctac      120

ggctacgata ccgcggtcat ttcgggagcc atcggtttct tgaaaacgct ctatcacctc      180

tcgcccttca tgcagggatt ggtcatctcg agcatcatga tcggcggcgt catcggcgtg      240

gccgtctccg gcttcttgag cgatcgcgtc ggccgccgca aggtcctcat gacggccgcc      300

gttctgttcg cggtggcggc gtttgtgtct gccatctcct ccgatgtcac cacgctcatt      360

cttgcgcgaa tcgtcggagg cctcggcatc ggcatgggat cggcgctctc ggtgacctac      420

atctccgagt gtgcgccgac gcagatccgc ggggcgctgt cgtcgctgta tcagctgctc      480

accatcatcg gcatctttct cacctatctc accaactact tgattcaacg ctccggatcg      540

gtcgcctggg acgtgcacac gggttggcgc tggatgctgg ggctgggctg cgtgccagcg      600

gctatcttct ttttcgtcct tctgtttgca cccgagagtc cgcggtggtt ggcgaaggtc      660

ggccggatcg acgaggcgct gcggatcttg gtgcgcatca atgggccgag tgctggtcaa      720

cgtgaactcg agtccattcg cgaatcgatt gcgagtgaaa gcgctgcaag catccgcgat      780

cttctgaaac ccggttggcg caaggcgctt ggtgtcggga ttcttcttgc gctgttcaat      840

caaatcatcg gcatgaacgc cgtgacgtat tacggccccg aaatcttcag gatggtgggg      900

ttcagtctca actccgattt cgagattcaa gcgttcttcg gcgccatgtg ggtcgtgttt      960

accgttgtcg cggtcgtcct gatcgatcgc gtcggcagaa agcccctgat gatcgtcggc     1020

tccgcgctga tggccatctt catggcgctg atgggcttga ccttttacct gcacgttcac     1080

aacgggttct ggctcgtgct cttcatcatg ggcttcacgg cggcgttcag cgtgtcgatg     1140

ggtccgattc cttggatcat gattccggaa atctttccga atcacctgcg cgcccgcgcg     1200

gccggcgtgg caaccatctt cctgtgggga gccaactggg ccatcggcca gtttacgcca     1260

gtattgctga acgatttcgg cggcgcctac accttctgga tgtttgcagt catcaacatc     1320

cttggggtgc tgttcgtcac ggcctgggtg ccggagacga aaaaccgttc cctggaggag     1380

atcgaatcca tctggatggc ttcggggcgc ggggtgtcgc tgtcgcaacg agacgcgcac     1440

gaacgcgcga agcgcgccca tttttga                                         1467


<210>   37
<211>   445
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   37
Ser Met Gly Phe Val Ile Leu Ile Ser Cys Ala Ala Gly Leu Gly Gly 
                5                   10                  15      

Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala Ile Gly Phe 
            20                  25                  30          

Leu Lys Asp Leu Tyr Ser Leu Ser Pro Phe Met Glu Gly Leu Val Ile 
        35                  40                  45              

Ser Ser Ile Met Ile Gly Gly Val Val Gly Val Gly Ile Ser Gly Phe 
    50                  55                  60                  

Leu Ser Asp Arg Phe Gly Arg Arg Lys Ile Leu Met Thr Ala Ala Leu 
65                  70                  75                  80  

Leu Phe Ala Ile Ser Ala Ile Val Ser Ala Leu Ser Gln Asp Val Ser 
                85                  90                  95      

Thr Leu Ile Ile Ala Arg Ile Ile Gly Gly Leu Gly Ile Gly Met Gly 
            100                 105                 110         

Ser Ser Leu Ser Val Thr Tyr Ile Thr Glu Ala Ala Pro Pro Ala Ile 
        115                 120                 125             

Arg Gly Ser Leu Ser Ser Leu Tyr Gln Leu Phe Thr Ile Leu Gly Ile 
    130                 135                 140                 

Ser Ala Thr Tyr Phe Ile Asn Leu Ala Val Gln Arg Ser Gly Thr Tyr 
145                 150                 155                 160 

Glu Trp Gly Val His Thr Gly Trp Arg Trp Met Leu Ala Tyr Gly Met 
                165                 170                 175     

Val Pro Ser Val Ile Phe Phe Leu Val Leu Leu Val Val Pro Glu Ser 
            180                 185                 190         

Pro Arg Trp Leu Ala Lys Ala Gly Lys Thr Asn Glu Ala Leu Lys Ile 
        195                 200                 205             

Leu Thr Arg Ile Asn Gly Glu Thr Val Ala Lys Glu Glu Leu Lys Asn 
    210                 215                 220                 

Ile Glu Asn Ser Leu Lys Ile Glu Gln Met Gly Ser Leu Ser Gln Leu 
225                 230                 235                 240 

Phe Lys Pro Gly Leu Arg Lys Ala Leu Val Ile Gly Ile Leu Leu Ala 
                245                 250                 255     

Leu Phe Asn Gln Val Ile Gly Met Asn Ala Ile Thr Tyr Tyr Gly Pro 
            260                 265                 270         

Glu Ile Phe Lys Met Met Gly Phe Gly Gln Asn Ala Gly Phe Val Thr 
        275                 280                 285             

Thr Cys Ile Val Gly Val Val Glu Val Ile Phe Thr Val Ile Ala Val 
    290                 295                 300                 

Leu Leu Ile Asp Lys Val Gly Arg Lys Lys Leu Met Ser Ile Gly Ser 
305                 310                 315                 320 

Ala Phe Met Ala Ile Phe Met Ile Leu Ile Gly Thr Ser Phe Tyr Phe 
                325                 330                 335     

Glu Leu Thr Ser Gly Ile Met Met Ile Val Leu Ile Leu Gly Phe Val 
            340                 345                 350         

Ala Ala Phe Cys Val Ser Val Gly Pro Ile Thr Trp Ile Met Ile Ser 
        355                 360                 365             

Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala Ala Gly Ile Ala Thr 
    370                 375                 380                 

Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly Gln Phe Val Pro Met 
385                 390                 395                 400 

Met Ile Asp Ser Phe Gly Leu Ala Tyr Thr Phe Trp Ile Phe Ala Val 
                405                 410                 415     

Ile Asn Ile Leu Cys Phe Leu Phe Val Val Thr Ile Cys Pro Glu Thr 
            420                 425                 430         

Lys Asn Lys Ser Leu Glu Glu Ile Glu Lys Leu Trp Ile 
        435                 440                 445 

<210>   38
<211>   447
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   38
Gln His Ser Lys Trp Phe Val Ile Leu Ile Ser Cys Ala Ala Gly Leu 
                5                   10                  15      

Gly Gly Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala Ile 
            20                  25                  30          

Gly Phe Leu Lys Asp Leu Tyr Arg Leu Ser Pro Phe Met Glu Gly Leu 
        35                  40                  45              

Val Ile Ser Ser Ile Met Ile Gly Gly Val Phe Gly Val Gly Ile Ser 
    50                  55                  60                  

Gly Phe Leu Ser Asp Arg Phe Gly Arg Arg Lys Ile Leu Met Ala Ala 
65                  70                  75                  80  

Ala Leu Leu Phe Ala Val Ser Ala Val Val Ser Ala Leu Ser Gln Ser 
                85                  90                  95      

Val Ser Ser Leu Val Ile Ala Arg Val Ile Gly Gly Leu Gly Ile Gly 
            100                 105                 110         

Met Gly Ser Ser Leu Ser Val Thr Tyr Ile Thr Glu Ala Ala Pro Pro 
        115                 120                 125             

Ala Ile Arg Gly Ser Leu Ser Ser Leu Tyr Gln Leu Phe Thr Ile Leu 
    130                 135                 140                 

Gly Ile Ser Gly Thr Tyr Phe Ile Asn Leu Ala Val Gln Gln Ser Gly 
145                 150                 155                 160 

Ser Tyr Glu Trp Gly Val His Thr Gly Trp Arg Trp Met Leu Ala Tyr 
                165                 170                 175     

Gly Met Ile Pro Ser Val Ile Phe Phe Ile Val Leu Leu Ile Val Pro 
            180                 185                 190         

Glu Ser Pro Arg Trp Leu Ala Lys Ala Gly Arg Arg Asn Glu Ala Leu 
        195                 200                 205             

Ala Val Leu Thr Arg Ile Asn Gly Glu Gln Thr Ala Lys Glu Glu Ile 
    210                 215                 220                 

Lys Gln Ile Glu Thr Ser Leu Gln Leu Glu Lys Met Gly Ser Leu Ser 
225                 230                 235                 240 

Gln Leu Phe Lys Pro Gly Leu Arg Lys Ala Leu Val Ile Gly Ile Leu 
                245                 250                 255     

Leu Ala Leu Phe Asn Gln Val Ile Gly Met Asn Ala Ile Thr Tyr Tyr 
            260                 265                 270         

Gly Pro Glu Ile Phe Lys Met Met Gly Phe Gly Gln Asn Ala Gly Phe 
        275                 280                 285             

Ile Thr Thr Cys Ile Val Gly Val Val Glu Val Ile Phe Thr Ile Ile 
    290                 295                 300                 

Ala Val Leu Leu Val Asp Lys Val Gly Arg Lys Lys Leu Met Gly Val 
305                 310                 315                 320 

Gly Ser Ala Phe Met Ala Leu Phe Met Ile Leu Ile Gly Ala Ser Phe 
                325                 330                 335     

Tyr Phe Gln Leu Ala Ser Gly Pro Ala Leu Val Val Ile Ile Leu Gly 
            340                 345                 350         

Phe Val Ala Ala Phe Cys Val Ser Val Gly Pro Ile Thr Trp Ile Met 
        355                 360                 365             

Ile Ser Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala Ala Gly Ile 
    370                 375                 380                 

Ala Thr Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly Gln Phe Val 
385                 390                 395                 400 

Pro Met Met Ile Ser Gly Leu Gly Leu Ala Tyr Thr Phe Trp Ile Phe 
                405                 410                 415     

Ala Val Ile Asn Ile Leu Cys Phe Leu Phe Val Val Thr Ile Cys Pro 
            420                 425                 430         

Glu Thr Lys Asn Lys Ser Leu Glu Glu Ile Glu Lys Leu Trp Ile 
        435                 440                 445         

<210>   39
<211>   449
<212>   PRT
<213>   Clostridium acetobutylicum ATCC 824

<400>   39
Ser Leu Leu Phe Ile Val Leu Ile Ser Cys Ala Ala Gly Leu Gly Gly 
                5                   10                  15      

Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala Ile Gly Phe 
            20                  25                  30          

Leu Lys Lys Leu Tyr Asn Leu Ser Pro Ala Met Gln Gly Phe Val Ile 
        35                  40                  45              

Ser Ser Ile Met Val Gly Gly Val Leu Gly Val Gly Phe Ser Gly Phe 
    50                  55                  60                  

Leu Gly Asp Ala Ile Gly Arg Arg Lys Val Leu Met Leu Ala Ala Ala 
65                  70                  75                  80  

Leu Phe Ala Ile Ser Ala Val Ile Ser Ser Ile Ser Thr Ser Ala Phe 
                85                  90                  95      

Met Leu Ile Phe Ala Arg Ile Val Gly Gly Leu Gly Ile Gly Met Ala 
            100                 105                 110         

Ser Ala Leu Ser Val Thr Tyr Ile Thr Glu Cys Ala Pro Pro Ser Ile 
        115                 120                 125             

Arg Gly Arg Leu Ser Ser Leu Tyr Gln Leu Phe Thr Ile Leu Gly Ile 
    130                 135                 140                 

Ser Ile Thr Phe Phe Val Asn Leu Gly Ile Val Asn Met Gly Ser Glu 
145                 150                 155                 160 

Thr Trp Arg Val Ser Thr Gly Trp Arg Tyr Met Leu Ala Cys Gly Thr 
                165                 170                 175     

Val Pro Ala Ile Val Phe Leu Ile Thr Leu Phe Phe Val Pro Glu Ser 
            180                 185                 190         

Pro Arg Phe Leu Val Lys Ser Gly Asn Ile Lys Lys Ala Ala Ala Val 
        195                 200                 205             

Leu Thr Lys Ile Asn Gly Ala Glu Ile Ala Lys Gln Glu Leu Asp Ser 
    210                 215                 220                 

Ile Ser Lys Ser Leu Ala Thr Glu Asn Asp Ser Ser Leu Gly Gln Leu 
225                 230                 235                 240 

Leu Gln Pro Gly Leu Arg Arg Ala Leu Leu Ile Gly Ile Phe Leu Ala 
                245                 250                 255     

Ile Phe Asn Gln Ala Ile Gly Met Asn Ser Ile Thr Tyr Tyr Gly Pro 
            260                 265                 270         

Glu Ile Phe Gln Met Ile Gly Phe Lys Asn Asn Ser Ser Phe Leu Ala 
        275                 280                 285             

Thr Ser Val Ile Gly Val Val Glu Val Phe Ser Thr Ile Leu Ala Met 
    290                 295                 300                 

Phe Leu Ile Asp Lys Leu Gly Arg Lys Lys Leu Met Glu Ile Gly Ser 
305                 310                 315                 320 

Ala Ala Met Ala Val Phe Met Leu Leu Ile Gly Thr Ser Phe Tyr Ile 
                325                 330                 335     

Lys Leu Ser Asn Gly Phe Val Ile Leu Ile Phe Ile Ile Cys Phe Val 
            340                 345                 350         

Val Ser Phe Cys Ile Ser Met Gly Pro Ile Pro Trp Ile Met Ile Pro 
        355                 360                 365             

Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala Thr Gly Ile Ala Thr 
    370                 375                 380                 

Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly Gln Phe Thr Pro Met 
385                 390                 395                 400 

Leu Leu Asn Gly Ile Gly Gly Ala Tyr Thr Phe Trp Ile Phe Cys Gly 
                405                 410                 415     

Ile Asn Val Ile Cys Phe Leu Val Val Thr Thr Lys Val Pro Glu Thr 
            420                 425                 430         

Lys Asn Lys Ser Leu Glu Glu Ile Glu Lys Phe Trp Ile Pro Lys Ser 
        435                 440                 445             

Lys 
    

<210>   40
<211>   458
<212>   PRT
<213>   Pedobacter sp. BAL39

<400>   40
Gln Gly Ser Lys Ser Gly Thr Tyr Leu Tyr Leu Ile Cys Leu Val Ala 
                5                   10                  15      

Ala Leu Gly Gly Phe Leu Phe Gly Phe Asp Thr Ala Val Ile Ser Gly 
            20                  25                  30          

Thr Val Ser Leu Val Lys Thr Asp Phe Asp Leu Asn Ala Val Ser Glu 
        35                  40                  45              

Gly Trp Phe Val Ser Cys Ala Leu Leu Gly Cys Ile Ile Gly Val Ser 
    50                  55                  60                  

Phe Ser Gly Lys Leu Ser Asp Arg Tyr Gly Arg Lys Ile Val Leu Ile 
65                  70                  75                  80  

Leu Ser Ala Val Leu Phe Leu Ala Ser Ala Leu Gly Cys Met Ile Ser 
                85                  90                  95      

Ser Ser Phe Asp Val Leu Ile Ile Phe Arg Leu Ile Gly Gly Leu Gly 
            100                 105                 110         

Ile Gly Val Ala Ser Met Val Ser Pro Leu Tyr Ile Ser Glu Phe Ser 
        115                 120                 125             

Pro Ser Arg Tyr Arg Gly Met Met Val Ser Leu Tyr Gln Leu Ala Leu 
    130                 135                 140                 

Thr Ile Gly Ile Val Leu Ala Tyr Phe Ser Asn Ala Tyr Leu Ala Asn 
145                 150                 155                 160 

His Ile Ser Asp Asp Tyr Gly Thr Gly Ser Met Gln Thr Ile Phe Ser 
                165                 170                 175     

Val Glu Val Trp Arg Gly Met Leu Gly Leu Gly Ala Ile Pro Ala Ala 
            180                 185                 190         

Ile Phe Leu Ile Ser Leu Phe Phe Val Pro Glu Ser Pro Arg Trp Leu 
        195                 200                 205             

Leu Leu Arg Gly Lys Asp Gln Lys Ala Arg Gln Val Leu Val Lys Ile 
    210                 215                 220                 

Asp Gly Ala Pro Ala Ala Asp Arg Glu Ile Ala Ala Phe Lys Ala Gln 
225                 230                 235                 240 

Asp Asp Asn Val Glu Gly Ser Leu Lys Glu Leu Phe Arg Pro Val Phe 
                245                 250                 255     

Arg Lys Ala Leu Tyr Ile Gly Ile Leu Leu Pro Phe Leu Ser Gln Ile 
            260                 265                 270         

Cys Gly Ile Asn Ala Val Ile Tyr Tyr Gly Pro Arg Ile Leu Glu Gln 
        275                 280                 285             

Ala Gly Phe Thr Leu Asn Asn Ala Leu Gly Gly Gln Val Thr Ile Gly 
    290                 295                 300                 

Leu Val Asn Val Val Phe Thr Phe Val Ala Ile Phe Thr Ile Asp Lys 
305                 310                 315                 320 

Trp Gly Arg Lys Pro Leu Leu Phe Val Gly Val Gly Gly Ala Val Ile 
                325                 330                 335     

Ser Leu Ile Ile Ile Gly Val Leu Phe Ala Leu Gly Val Thr Ala Gly 
            340                 345                 350         

Pro Trp Ile Leu Ile Phe Ile Leu Ala Phe Ile Ala Cys Phe Ala Phe 
        355                 360                 365             

Ser Phe Gly Pro Val Cys Trp Val Val Val Gly Glu Ile Phe Pro Asn 
    370                 375                 380                 

Ala Val Arg Gly Lys Ala Met Ala Leu Ala Thr Leu Ser Leu Trp Ile 
385                 390                 395                 400 

Gly Asn Phe Leu Val Gly Gln Leu Thr Pro Val Leu Leu Glu Gly Leu 
                405                 410                 415     

Gly Ser Ser Trp Thr Phe Phe Leu Phe Ala Ile Cys Cys Ser Pro Ala 
            420                 425                 430         

Leu Trp Ile Thr Trp Lys Leu Ile Pro Glu Thr Lys Gly Arg Ser Leu 
        435                 440                 445             

Glu Asp Ile Glu Asn Tyr Trp Lys Lys Ser 
    450                 455             

<210>   41
<211>   446
<212>   PRT
<213>   Pediococcus pentosaceus ATCC 25745

<400>   41
Tyr Val Ile Leu Ile Ser Cys Ala Ala Ala Leu Gly Gly Leu Leu Phe 
                5                   10                  15      

Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala Val Gly Phe Leu Gln Ile 
            20                  25                  30          

Lys Phe Thr Leu Ser Ser Ala Gln Val Gly Trp Val Thr Ser Cys Ile 
        35                  40                  45              

Leu Ile Gly Cys Ala Leu Gly Val Ser Ile Ala Gly Ile Leu Ser Asp 
    50                  55                  60                  

Leu Phe Gly Arg Lys Lys Ile Leu Ala Leu Ser Ala Val Ile Phe Ala 
65                  70                  75                  80  

Leu Ser Ser Leu Gly Ala Ala Phe Ala Gly Ser Tyr Met Ile Leu Val 
                85                  90                  95      

Ile Trp Arg Met Leu Ala Gly Ile Gly Ile Gly Leu Thr Ser Leu Ile 
            100                 105                 110         

Thr Pro Leu Tyr Ile Ala Glu Met Ala Pro Ser Asn Val Arg Gly Lys 
        115                 120                 125             

Leu Val Ser Val Asn Gln Leu Ala Ile Thr Ile Gly Ile Phe Ile Val 
    130                 135                 140                 

Tyr Phe Val Asn Ala Ala Ile Ala Ser Asn Ala Thr Gln Leu Trp Asn 
145                 150                 155                 160 

Val Ser Thr Gly Trp Arg Trp Met Met Gly Val Gly Val Ile Pro Ser 
                165                 170                 175     

Leu Leu Phe Leu Ile Ala Leu Ile Pro Ala Gly Glu Ser Pro Arg Trp 
            180                 185                 190         

Leu Ser Gln His Gly Lys Ser Glu Ala Ala Tyr Lys Val Leu Gln Lys 
        195                 200                 205             

Val Glu Ile Ser Asp Glu Ala Ala Glu Lys Ser Leu Glu Glu Ile Gln 
    210                 215                 220                 

Met Ser Glu Glu Val Val Asp Asp Thr Lys Phe Arg Asp Leu Phe Asn 
225                 230                 235                 240 

Lys Thr Trp Leu Pro Val Leu Ile Ile Gly Val Leu Leu Ala Leu Phe 
                245                 250                 255     

Gln Gln Phe Ser Gly Ser Asn Ala Ile Met Tyr Tyr Ala Pro Glu Ile 
            260                 265                 270         

Phe Lys Gly Ala Gly Phe Gly Gln Ser Gly Ala Phe Met Ala Thr Val 
        275                 280                 285             

Ser Ile Gly Val Ile Asn Met Val Ile Thr Ile Val Ala Leu Gly Leu 
    290                 295                 300                 

Val Asp Lys Ile Gly Arg Lys Lys Leu Leu Gly Trp Gly Ser Phe Ala 
305                 310                 315                 320 

Met Ser Cys Cys Leu Leu Val Val Ser Ile Cys Phe Phe Val His Ala 
                325                 330                 335     

Ala Thr Ser Ile Thr Leu Thr Phe Val Leu Leu Ala Ile Ala Ala Tyr 
            340                 345                 350         

Ala Val Ser Leu Ala Pro Val Thr Trp Ile Leu Ile Ser Glu Ile Phe 
        355                 360                 365             

Pro Leu Lys Ile Arg Gly Arg Ala Met Ser Ile Cys Thr Ala Val Leu 
    370                 375                 380                 

Trp Leu Ser Asp Phe Thr Leu Ser Tyr Thr Phe Pro Ile Leu Thr Gln 
385                 390                 395                 400 

Asn Ile Gly Glu Gly Trp Thr Phe Met Leu Tyr Val Val Val Thr Ala 
                405                 410                 415     

Leu Ser Ala Ile Phe Val Trp Lys Leu Val Pro Glu Thr Arg Gly Lys 
            420                 425                 430         

Ser Leu Glu Glu Ile Glu Val Tyr Trp His Ala Lys Ser Lys 
        435                 440                 445     

<210>   42
<211>   488
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   42
Met Ala Asp Val Val Pro Thr Pro Trp Arg Arg Phe Ala Met Ser Thr 
                5                   10                  15      

Gln Gln Thr Gln Gly Ser Arg Ala Tyr Ala Val Thr Ile Ser Leu Ala 
            20                  25                  30          

Ala Ala Met Gly Gly Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser 
        35                  40                  45              

Gly Ala Ile Gly Phe Leu Lys Thr Leu Tyr His Leu Ser Pro Phe Met 
    50                  55                  60                  

Gln Gly Leu Val Ile Ser Ser Ile Met Ile Gly Gly Val Ile Gly Val 
65                  70                  75                  80  

Ala Val Ser Gly Phe Leu Ser Asp Arg Val Gly Arg Arg Lys Val Leu 
                85                  90                  95      

Met Thr Ala Ala Val Leu Phe Ala Val Ala Ala Phe Val Ser Ala Ile 
            100                 105                 110         

Ser Ser Asp Val Thr Thr Leu Ile Leu Ala Arg Ile Val Gly Gly Leu 
        115                 120                 125             

Gly Ile Gly Met Gly Ser Ala Leu Ser Val Thr Tyr Ile Ser Glu Cys 
    130                 135                 140                 

Ala Pro Thr Gln Ile Arg Gly Ala Leu Ser Ser Leu Tyr Gln Leu Leu 
145                 150                 155                 160 

Thr Ile Ile Gly Ile Phe Leu Thr Tyr Leu Thr Asn Tyr Leu Ile Gln 
                165                 170                 175     

Arg Ser Gly Ser Val Ala Trp Asp Val His Thr Gly Trp Arg Trp Met 
            180                 185                 190         

Leu Gly Leu Gly Cys Val Pro Ala Ala Ile Phe Phe Phe Val Leu Leu 
        195                 200                 205             

Phe Ala Pro Glu Ser Pro Arg Trp Leu Ala Lys Val Gly Arg Ile Asp 
    210                 215                 220                 

Glu Ala Leu Arg Ile Leu Val Arg Ile Asn Gly Pro Ser Ala Gly Gln 
225                 230                 235                 240 

Arg Glu Leu Glu Ser Ile Arg Glu Ser Ile Ala Ser Glu Ser Ala Ala 
                245                 250                 255     

Ser Ile Arg Asp Leu Leu Lys Pro Gly Trp Arg Lys Ala Leu Gly Val 
            260                 265                 270         

Gly Ile Leu Leu Ala Leu Phe Asn Gln Ile Ile Gly Met Asn Ala Val 
        275                 280                 285             

Thr Tyr Tyr Gly Pro Glu Ile Phe Arg Met Val Gly Phe Ser Leu Asn 
    290                 295                 300                 

Ser Asp Phe Glu Ile Gln Ala Phe Phe Gly Ala Met Trp Val Val Phe 
305                 310                 315                 320 

Thr Val Val Ala Val Val Leu Ile Asp Arg Val Gly Arg Lys Pro Leu 
                325                 330                 335     

Met Ile Val Gly Ser Ala Leu Met Ala Ile Phe Met Ala Leu Met Gly 
            340                 345                 350         

Leu Thr Phe Tyr Leu His Val His Asn Gly Phe Trp Leu Val Leu Phe 
        355                 360                 365             

Ile Met Gly Phe Thr Ala Ala Phe Ser Val Ser Met Gly Pro Ile Pro 
    370                 375                 380                 

Trp Ile Met Ile Pro Glu Ile Phe Pro Gln His Leu Arg Ala Arg Ala 
385                 390                 395                 400 

Ala Gly Val Ala Thr Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly 
                405                 410                 415     

Gln Phe Thr Pro Val Leu Leu Asn Asp Phe Gly Gly Ala Tyr Thr Phe 
            420                 425                 430         

Trp Met Phe Ala Val Ile Asn Ile Leu Gly Val Leu Phe Val Thr Ala 
        435                 440                 445             

Trp Val Pro Glu Thr Lys Asn Arg Ser Leu Glu Glu Ile Glu Ser Ile 
    450                 455                 460                 

Trp Met Ala Ser Gly Arg Gly Val Ser Leu Ser Gln Arg Asp Ala His 
465                 470                 475                 480 

Glu Arg Ala Lys Arg Ala His Phe 
                485             

<210>   43
<211>   488
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   43
Met Ala Asp Val Val Pro Thr Pro Trp Arg Arg Phe Ala Met Ser Thr 
                5                   10                  15      

Gln Gln Thr Gln Gly Ser Arg Ala Tyr Ala Val Thr Ile Ser Leu Ala 
            20                  25                  30          

Ala Ala Met Gly Gly Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser 
        35                  40                  45              

Gly Ala Ile Gly Phe Leu Lys Thr Leu Tyr His Leu Ser Pro Phe Met 
    50                  55                  60                  

Gln Gly Leu Val Ile Ser Ser Ile Met Ile Gly Gly Val Ile Gly Val 
65                  70                  75                  80  

Ala Val Ser Gly Phe Leu Ser Asp Arg Val Gly Arg Arg Lys Val Leu 
                85                  90                  95      

Met Thr Ala Ala Val Leu Phe Ala Val Ala Ala Phe Val Ser Ala Ile 
            100                 105                 110         

Ser Ser Asp Val Thr Thr Leu Ile Leu Ala Arg Ile Val Gly Gly Leu 
        115                 120                 125             

Gly Ile Gly Met Gly Ser Ala Leu Ser Val Thr Tyr Ile Ser Glu Cys 
    130                 135                 140                 

Ala Pro Thr Gln Ile Arg Gly Ala Leu Ser Ser Leu Tyr Gln Leu Leu 
145                 150                 155                 160 

Thr Ile Ile Gly Ile Phe Leu Thr Tyr Leu Thr Asn Tyr Leu Ile Gln 
                165                 170                 175     

Arg Ser Gly Ser Val Ala Trp Asp Val His Thr Gly Trp Arg Trp Met 
            180                 185                 190         

Leu Gly Leu Gly Cys Val Pro Ala Ala Ile Phe Phe Phe Val Leu Leu 
        195                 200                 205             

Phe Ala Pro Glu Ser Pro Arg Trp Leu Ala Lys Val Gly Arg Ile Asp 
    210                 215                 220                 

Glu Ala Leu Arg Ile Leu Val Arg Ile Asn Gly Pro Ser Ala Gly Gln 
225                 230                 235                 240 

Arg Glu Leu Glu Ser Ile Arg Glu Ser Ile Ala Ser Glu Ser Ala Ala 
                245                 250                 255     

Ser Ile Arg Asp Leu Leu Lys Pro Gly Trp Arg Lys Ala Leu Gly Val 
            260                 265                 270         

Gly Leu Leu Leu Ala Leu Phe Asn Gln Ile Ile Gly Met Asn Ala Val 
        275                 280                 285             

Thr Tyr Tyr Gly Pro Glu Ile Phe Arg Met Val Gly Phe Ser Leu Asn 
    290                 295                 300                 

Ser Asp Phe Glu Ile Gln Ala Phe Phe Gly Ala Met Trp Val Val Phe 
305                 310                 315                 320 

Thr Val Val Ala Val Val Leu Ile Asp Arg Val Gly Arg Lys Pro Leu 
                325                 330                 335     

Met Ile Val Gly Ser Ala Leu Met Ala Ile Phe Met Ala Leu Met Gly 
            340                 345                 350         

Leu Thr Phe Tyr Leu His Val His Asn Gly Phe Trp Leu Val Leu Phe 
        355                 360                 365             

Ile Met Gly Phe Thr Ala Ala Phe Ser Val Ser Met Gly Pro Ile Pro 
    370                 375                 380                 

Trp Ile Met Ile Pro Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala 
385                 390                 395                 400 

Ala Gly Val Ala Thr Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly 
                405                 410                 415     

Gln Phe Thr Pro Val Leu Leu Asn Asp Phe Gly Gly Ala Tyr Thr Phe 
            420                 425                 430         

Trp Met Phe Ala Val Ile Asn Ile Leu Gly Val Leu Phe Val Thr Ala 
        435                 440                 445             

Trp Val Pro Glu Thr Lys Asn Arg Ser Leu Glu Glu Ile Glu Ser Ile 
    450                 455                 460                 

Trp Met Ala Ser Gly Arg Gly Val Ser Leu Ser Gln Arg Asp Ala His 
465                 470                 475                 480 

Glu Arg Ala Lys Arg Ala His Phe 
                485             

<210>   44
<211>   488
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   44
Met Ala Asp Val Val Pro Thr Pro Trp Arg Arg Phe Ala Met Ser Thr 
                5                   10                  15      

Gln Gln Thr Gln Gly Ser Arg Ala Tyr Ala Val Thr Ile Ser Leu Ala 
            20                  25                  30          

Ala Ala Met Gly Gly Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser 
        35                  40                  45              

Gly Ala Ile Gly Phe Leu Lys Thr Leu Tyr His Leu Ser Pro Phe Met 
    50                  55                  60                  

Gln Gly Leu Val Ile Ser Ser Ile Met Ile Gly Gly Val Ile Gly Val 
65                  70                  75                  80  

Ala Val Ser Gly Phe Leu Ser Asp Arg Val Gly Arg Arg Lys Val Leu 
                85                  90                  95      

Met Thr Ala Ala Val Leu Phe Ala Val Ala Ala Phe Val Ser Ala Ile 
            100                 105                 110         

Ser Ser Asp Val Thr Thr Leu Ile Leu Ala Arg Ile Val Gly Gly Leu 
        115                 120                 125             

Gly Ile Gly Met Gly Ser Ala Leu Ser Val Thr Tyr Ile Ser Glu Cys 
    130                 135                 140                 

Ala Pro Thr Gln Ile Arg Gly Ala Leu Ser Ser Leu Tyr Gln Leu Leu 
145                 150                 155                 160 

Thr Ile Ile Gly Ile Phe Leu Thr Tyr Leu Thr Asn Tyr Leu Ile Gln 
                165                 170                 175     

Arg Ser Gly Ser Val Ala Trp Asp Val His Thr Gly Trp Arg Trp Met 
            180                 185                 190         

Leu Gly Leu Gly Cys Val Pro Ala Ala Ile Phe Phe Phe Val Leu Leu 
        195                 200                 205             

Phe Ala Pro Glu Ser Pro Arg Trp Leu Ala Lys Val Gly Arg Ile Asp 
    210                 215                 220                 

Glu Ala Leu Arg Ile Leu Val Arg Ile Asn Gly Pro Ser Ala Gly Gln 
225                 230                 235                 240 

Arg Glu Leu Glu Ser Ile Arg Glu Ser Ile Ala Ser Glu Ser Ala Ala 
                245                 250                 255     

Ser Ile Arg Asp Leu Leu Lys Pro Gly Trp Arg Lys Ala Leu Gly Val 
            260                 265                 270         

Gly Ile Leu Leu Ala Leu Phe Asn Gln Ile Ile Gly Met Asn Ala Val 
        275                 280                 285             

Thr Tyr Tyr Gly Pro Glu Ile Phe Arg Met Val Gly Phe Ser Leu Asn 
    290                 295                 300                 

Ser Asp Phe Glu Ile Gln Ala Phe Phe Gly Ala Met Trp Val Val Phe 
305                 310                 315                 320 

Thr Val Val Ala Val Ile Leu Ile Asp Arg Val Gly Arg Lys Pro Leu 
                325                 330                 335     

Met Ile Val Gly Ser Ala Leu Met Ala Ile Phe Met Ala Leu Met Gly 
            340                 345                 350         

Leu Thr Phe Tyr Leu His Val His Asn Gly Phe Trp Leu Val Leu Phe 
        355                 360                 365             

Ile Met Gly Phe Thr Ala Ala Phe Ser Val Ser Met Gly Pro Ile Pro 
    370                 375                 380                 

Trp Ile Met Ile Pro Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala 
385                 390                 395                 400 

Ala Gly Val Ala Thr Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly 
                405                 410                 415     

Gln Phe Thr Pro Val Leu Leu Asn Asp Phe Gly Gly Ala Tyr Thr Phe 
            420                 425                 430         

Trp Met Phe Ala Val Ile Asn Ile Leu Gly Val Leu Phe Val Thr Ala 
        435                 440                 445             

Trp Val Pro Glu Thr Lys Asn Arg Ser Leu Glu Glu Ile Glu Ser Ile 
    450                 455                 460                 

Trp Met Ala Ser Gly Arg Gly Val Ser Leu Ser Gln Arg Asp Ala His 
465                 470                 475                 480 

Glu Arg Ala Lys Arg Ala His Phe 
                485             

<210>   45
<211>   488
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   45
Met Ala Asp Val Val Pro Thr Pro Trp Arg Arg Phe Ala Met Ser Thr 
                5                   10                  15      

Gln Gln Thr Gln Gly Ser Arg Ala Tyr Ala Val Thr Ile Ser Leu Ala 
            20                  25                  30          

Ala Ala Met Gly Gly Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser 
        35                  40                  45              

Gly Ala Ile Gly Phe Leu Lys Thr Leu Tyr His Leu Ser Pro Phe Met 
    50                  55                  60                  

Gln Gly Leu Val Ile Ser Ser Ile Met Ile Gly Gly Val Ile Gly Val 
65                  70                  75                  80  

Ala Val Ser Gly Phe Leu Ser Asp Arg Val Gly Arg Arg Lys Val Leu 
                85                  90                  95      

Met Thr Ala Ala Val Leu Phe Ala Val Ala Ala Phe Val Ser Ala Ile 
            100                 105                 110         

Ser Ser Asp Val Thr Thr Leu Ile Leu Ala Arg Ile Val Gly Gly Leu 
        115                 120                 125             

Gly Ile Gly Met Gly Ser Ala Leu Ser Val Thr Tyr Ile Ser Glu Cys 
    130                 135                 140                 

Ala Pro Thr Gln Ile Arg Gly Ala Leu Ser Ser Leu Tyr Gln Leu Leu 
145                 150                 155                 160 

Thr Ile Ile Gly Ile Phe Leu Thr Tyr Leu Thr Asn Tyr Leu Ile Gln 
                165                 170                 175     

Arg Ser Gly Ser Val Ala Trp Asp Val His Thr Gly Trp Arg Trp Met 
            180                 185                 190         

Leu Gly Leu Gly Cys Val Pro Ala Ala Ile Phe Phe Phe Val Leu Leu 
        195                 200                 205             

Phe Ala Pro Glu Ser Pro Arg Trp Leu Ala Lys Val Gly Arg Ile Asp 
    210                 215                 220                 

Glu Ala Leu Arg Ile Leu Val Arg Ile Asn Gly Pro Ser Ala Gly Gln 
225                 230                 235                 240 

Arg Glu Leu Glu Ser Ile Arg Glu Ser Ile Ala Ser Glu Ser Ala Ala 
                245                 250                 255     

Ser Ile Arg Asp Leu Leu Lys Pro Gly Trp Arg Lys Ala Leu Gly Val 
            260                 265                 270         

Gly Ile Leu Leu Ala Leu Phe Asn Gln Ile Ile Gly Met Asn Ala Val 
        275                 280                 285             

Thr Tyr Tyr Gly Pro Glu Ile Phe Arg Met Val Gly Phe Ser Leu Asn 
    290                 295                 300                 

Ser Asp Phe Glu Ile Gln Ala Phe Phe Gly Ala Met Trp Val Val Phe 
305                 310                 315                 320 

Thr Val Val Ala Val Val Leu Ile Asp Arg Val Gly Arg Lys Pro Leu 
                325                 330                 335     

Met Ile Val Gly Ser Ala Leu Met Ala Ile Phe Met Ala Leu Met Gly 
            340                 345                 350         

Leu Thr Phe Tyr Leu His Val His Asn Gly Phe Trp Leu Val Leu Phe 
        355                 360                 365             

Ile Met Gly Phe Thr Ala Ala Phe Ser Val Ser Met Gly Pro Ile Pro 
    370                 375                 380                 

Trp Ile Met Ile Pro Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala 
385                 390                 395                 400 

Ala Gly Val Ala Thr Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly 
                405                 410                 415     

Gln Phe Thr Pro Val Leu Leu Asn Asp Phe Gly Gly Ala Tyr Thr Phe 
            420                 425                 430         

Trp Met Phe Ala Val Ile Asn Ile Leu Gly Val Leu Phe Val Thr Ala 
        435                 440                 445             

Trp Val Pro Glu Thr Lys Asn Arg Ser Leu Glu Glu Ile Glu Ser Ile 
    450                 455                 460                 

Trp Met Ala Ser Gly Arg Gly Val Ser Ile Ser Gln Arg Asp Ala His 
465                 470                 475                 480 

Glu Arg Ala Lys Arg Ala His Phe 
                485             

<210>   46
<211>   488
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   46
Met Ala Asp Val Val Pro Thr Pro Trp Arg Arg Phe Ala Met Ser Thr 
                5                   10                  15      

Gln Gln Thr Gln Gly Ser Arg Ala Tyr Ala Val Thr Ile Ser Leu Ala 
            20                  25                  30          

Ala Ala Met Gly Gly Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser 
        35                  40                  45              

Gly Ala Ile Gly Phe Leu Lys Thr Leu Tyr His Leu Ser Pro Phe Met 
    50                  55                  60                  

Gln Gly Leu Val Ile Ser Ser Ile Met Ile Gly Gly Val Ile Gly Val 
65                  70                  75                  80  

Ala Val Ser Gly Phe Leu Ser Asp Arg Val Gly Arg Arg Lys Val Leu 
                85                  90                  95      

Met Thr Ala Ala Val Leu Phe Ala Val Ala Ala Phe Val Ser Ala Ile 
            100                 105                 110         

Ser Ser Asp Val Thr Thr Leu Ile Leu Ala Arg Ile Val Gly Gly Leu 
        115                 120                 125             

Gly Ile Gly Met Gly Ser Ala Leu Ser Val Thr Tyr Ile Ser Glu Cys 
    130                 135                 140                 

Ala Pro Thr Gln Ile Arg Gly Ala Leu Ser Ser Leu Tyr Gln Leu Leu 
145                 150                 155                 160 

Thr Leu Ile Gly Ile Phe Leu Thr Tyr Leu Thr Asn Tyr Leu Ile Gln 
                165                 170                 175     

Arg Ser Gly Ser Val Ala Trp Asp Val His Thr Gly Trp Arg Trp Met 
            180                 185                 190         

Leu Gly Leu Gly Cys Val Pro Ala Ala Ile Phe Phe Phe Val Leu Leu 
        195                 200                 205             

Phe Ala Pro Glu Ser Pro Arg Trp Leu Ala Lys Val Gly Arg Ile Asp 
    210                 215                 220                 

Glu Ala Leu Arg Ile Leu Val Arg Ile Asn Gly Pro Ser Ala Gly Gln 
225                 230                 235                 240 

Arg Glu Leu Glu Ser Ile Arg Glu Ser Ile Ala Ser Glu Ser Ala Ala 
                245                 250                 255     

Ser Ile Arg Asp Leu Leu Lys Pro Gly Trp Arg Lys Ala Leu Gly Val 
            260                 265                 270         

Gly Ile Leu Leu Ala Leu Phe Asn Gln Ile Ile Gly Met Asn Ala Val 
        275                 280                 285             

Thr Tyr Tyr Gly Pro Glu Ile Phe Arg Met Val Gly Phe Ser Leu Asn 
    290                 295                 300                 

Ser Asp Phe Glu Ile Gln Ala Phe Phe Gly Ala Met Trp Val Val Phe 
305                 310                 315                 320 

Thr Val Val Ala Val Val Leu Ile Asp Arg Val Gly Arg Lys Pro Leu 
                325                 330                 335     

Met Ile Val Gly Ser Ala Leu Met Ala Ile Phe Met Ala Leu Met Gly 
            340                 345                 350         

Leu Thr Phe Tyr Leu His Val His Asn Gly Phe Trp Leu Val Leu Phe 
        355                 360                 365             

Ile Met Gly Phe Thr Ala Ala Phe Ser Val Ser Met Gly Pro Ile Pro 
    370                 375                 380                 

Trp Ile Met Ile Pro Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala 
385                 390                 395                 400 

Ala Gly Val Ala Thr Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly 
                405                 410                 415     

Gln Phe Thr Pro Val Leu Leu Asn Asp Phe Gly Gly Ala Tyr Thr Phe 
            420                 425                 430         

Trp Met Phe Ala Val Ile Asn Ile Leu Gly Val Leu Phe Val Thr Ala 
        435                 440                 445             

Trp Val Pro Glu Thr Lys Asn Arg Ser Leu Glu Glu Ile Glu Ser Ile 
    450                 455                 460                 

Trp Met Ala Ser Gly Arg Gly Val Ser Leu Ser Gln Arg Asp Ala His 
465                 470                 475                 480 

Glu Arg Ala Lys Arg Ala His Phe 
                485             

<210>   47
<211>   1467
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   47
atggccgacg tcgtgcccac accttggagg aggttcgcca tgtccactca gcagacacaa       60

ggctctcgcg cctacgcggt gaccatctcg ctggcggcag cgatgggagg gctgctctac      120

ggctacgata ccgcggtcat ttcgggagcc atcggtttct tgaaaacgct ctatcacctc      180

tcgcccttca tgcagggatt ggtcatctcg agcatcatga tcggcggcgt catcggcgtg      240

gccgtctccg gcttcttgag cgatcgcgtc ggccgccgca aggtcctcat gacggccgcc      300

gttctgttcg cggtggcggc gtttgtgtct gccatctcct ccgatgtcac cacgctcatt      360

cttgcgcgaa tcgtcggagg cctcggcatc ggcatgggat cggcgctctc ggtgacctac      420

atctccgagt gtgcgccgac gcagatccgc ggggcgctgt cgtcgctgta tcagctgctc      480

accatcatcg gcatctttct cacctatctc accaactact tgattcaacg ctccggatcg      540

gtcgcctggg acgtgcacac gggttggcgc tggatgctgg ggctgggctg cgtgccagcg      600

gctatcttct ttttcgtcct tctgtttgca cccgagagtc cgcggtggtt ggcgaaggtc      660

ggccggatcg acgaggcgct gcggatcttg gtgcgcatca atgggccgag tgctggtcaa      720

cgtgaactcg agtccattcg cgaatcgatt gcgagtgaaa gcgctgcaag catccgcgat      780

cttctgaaac ccggttggcg caaggcgctt ggtgtcggga ttcttcttgc gctgttcaat      840

caaatcatcg gcatgaacgc cgtgacgtat tacggccccg aaatcttcag gatggtgggg      900

ttcagtctca actccgattt cgagattcaa gcgttcttcg gcgccatgtg ggtcgtgttt      960

accgttgtcg cggtcgtcct gatcgatcgc gtcggcagaa agcccctgat gatcgtcggc     1020

tccgcgctga tggccatctt catggcgctg atgggcttga ccttttacct gcacgttcac     1080

aacgggttct ggctcgtgct cttcatcatg ggcttcacgg cggcgttcag cgtgtcgatg     1140

ggtccgattc cttggatcat gattccggaa atctttccgc aacacctgcg cgcccgcgcg     1200

gccggcgtgg caaccatctt cctgtgggga gccaactggg ccatcggcca gtttacgcca     1260

gtattgctga acgatttcgg cggcgcctac accttctgga tgtttgcagt catcaacatc     1320

cttggggtgc tgttcgtcac ggcctgggtg ccggagacga aaaaccgttc cctggaggag     1380

atcgaatcca tctggatggc ttcggggcgc ggggtgtcgc tgtcgcaacg agacgcgcac     1440

gaacgcgcga agcgcgccca tttttga                                         1467


<210>   48
<211>   1467
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   48
atggccgacg tcgtgcccac accttggagg aggttcgcca tgtccactca gcagacacaa       60

ggctctcgcg cctacgcggt gaccatctcg ctggcggcag cgatgggagg gctgctctac      120

ggctacgata ccgcggtcat ttcgggagcc atcggtttct tgaaaacgct ctatcacctc      180

tcgcccttca tgcagggatt ggtcatctcg agcatcatga tcggcggcgt catcggcgtg      240

gccgtctccg gcttcttgag cgatcgcgtc ggccgccgca aggtcctcat gacggccgcc      300

gttctgttcg cggtggcggc gtttgtgtct gccatctcct ccgatgtcac cacgctcatt      360

cttgcgcgaa tcgtcggagg cctcggcatc ggcatgggat cggcgctctc ggtgacctac      420

atctccgagt gtgcgccgac gcagatccgc ggggcgctgt cgtcgctgta tcagctgctc      480

accatcatcg gcatctttct cacctatctc accaactact tgattcaacg ctccggatcg      540

gtcgcctggg acgtgcacac gggttggcgc tggatgctgg ggctgggctg cgtgccagcg      600

gctatcttct ttttcgtcct tctgtttgca cccgagagtc cgcggtggtt ggcgaaggtc      660

ggccggatcg acgaggcgct gcggatcttg gtgcgcatca atgggccgag tgctggtcaa      720

cgtgaactcg agtccattcg cgaatcgatt gcgagtgaaa gcgctgcaag catccgcgat      780

cttctgaaac ccggttggcg caaggcgctt ggtgtcgggt tacttcttgc gctgttcaat      840

caaatcatcg gcatgaacgc cgtgacgtat tacggccccg aaatcttcag gatggtgggg      900

ttcagtctca actccgattt cgagattcaa gcgttcttcg gcgccatgtg ggtcgtgttt      960

accgttgtcg cggtcgtcct gatcgatcgc gtcggcagaa agcccctgat gatcgtcggc     1020

tccgcgctga tggccatctt catggcgctg atgggcttga ccttttacct gcacgttcac     1080

aacgggttct ggctcgtgct cttcatcatg ggcttcacgg cggcgttcag cgtgtcgatg     1140

ggtccgattc cttggatcat gattccggaa atctttccga atcacctgcg cgcccgcgcg     1200

gccggcgtgg caaccatctt cctgtgggga gccaactggg ccatcggcca gtttacgcca     1260

gtattgctga acgatttcgg cggcgcctac accttctgga tgtttgcagt catcaacatc     1320

cttggggtgc tgttcgtcac ggcctgggtg ccggagacga aaaaccgttc cctggaggag     1380

atcgaatcca tctggatggc ttcggggcgc ggggtgtcgc tgtcgcaacg agacgcgcac     1440

gaacgcgcga agcgcgccca tttttga                                         1467


<210>   49
<211>   1467
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   49
atggccgacg tcgtgcccac accttggagg aggttcgcca tgtccactca gcagacacaa       60

ggctctcgcg cctacgcggt gaccatctcg ctggcggcag cgatgggagg gctgctctac      120

ggctacgata ccgcggtcat ttcgggagcc atcggtttct tgaaaacgct ctatcacctc      180

tcgcccttca tgcagggatt ggtcatctcg agcatcatga tcggcggcgt catcggcgtg      240

gccgtctccg gcttcttgag cgatcgcgtc ggccgccgca aggtcctcat gacggccgcc      300

gttctgttcg cggtggcggc gtttgtgtct gccatctcct ccgatgtcac cacgctcatt      360

cttgcgcgaa tcgtcggagg cctcggcatc ggcatgggat cggcgctctc ggtgacctac      420

atctccgagt gtgcgccgac gcagatccgc ggggcgctgt cgtcgctgta tcagctgctc      480

accatcatcg gcatctttct cacctatctc accaactact tgattcaacg ctccggatcg      540

gtcgcctggg acgtgcacac gggttggcgc tggatgctgg ggctgggctg cgtgccagcg      600

gctatcttct ttttcgtcct tctgtttgca cccgagagtc cgcggtggtt ggcgaaggtc      660

ggccggatcg acgaggcgct gcggatcttg gtgcgcatca atgggccgag tgctggtcaa      720

cgtgaactcg agtccattcg cgaatcgatt gcgagtgaaa gcgctgcaag catccgcgat      780

cttctgaaac ccggttggcg caaggcgctt ggtgtcggga ttcttcttgc gctgttcaat      840

caaatcatcg gcatgaacgc cgtgacgtat tacggccccg aaatcttcag gatggtgggg      900

ttcagtctca actccgattt cgagattcaa gcgttcttcg gcgccatgtg ggtcgtgttt      960

accgttgtcg cggtcattct gatcgatcgc gtcggcagaa agcccctgat gatcgtcggc     1020

tccgcgctga tggccatctt catggcgctg atgggcttga ccttttacct gcacgttcac     1080

aacgggttct ggctcgtgct cttcatcatg ggcttcacgg cggcgttcag cgtgtcgatg     1140

ggtccgattc cttggatcat gattccggaa atctttccga atcacctgcg cgcccgcgcg     1200

gccggcgtgg caaccatctt cctgtgggga gccaactggg ccatcggcca gtttacgcca     1260

gtattgctga acgatttcgg cggcgcctac accttctgga tgtttgcagt catcaacatc     1320

cttggggtgc tgttcgtcac ggcctgggtg ccggagacga aaaaccgttc cctggaggag     1380

atcgaatcca tctggatggc ttcggggcgc ggggtgtcgc tgtcgcaacg agacgcgcac     1440

gaacgcgcga agcgcgccca tttttga                                         1467


<210>   50
<211>   1467
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   50
atggccgacg tcgtgcccac accttggagg aggttcgcca tgtccactca gcagacacaa       60

ggctctcgcg cctacgcggt gaccatctcg ctggcggcag cgatgggagg gctgctctac      120

ggctacgata ccgcggtcat ttcgggagcc atcggtttct tgaaaacgct ctatcacctc      180

tcgcccttca tgcagggatt ggtcatctcg agcatcatga tcggcggcgt catcggcgtg      240

gccgtctccg gcttcttgag cgatcgcgtc ggccgccgca aggtcctcat gacggccgcc      300

gttctgttcg cggtggcggc gtttgtgtct gccatctcct ccgatgtcac cacgctcatt      360

cttgcgcgaa tcgtcggagg cctcggcatc ggcatgggat cggcgctctc ggtgacctac      420

atctccgagt gtgcgccgac gcagatccgc ggggcgctgt cgtcgctgta tcagctgctc      480

accatcatcg gcatctttct cacctatctc accaactact tgattcaacg ctccggatcg      540

gtcgcctggg acgtgcacac gggttggcgc tggatgctgg ggctgggctg cgtgccagcg      600

gctatcttct ttttcgtcct tctgtttgca cccgagagtc cgcggtggtt ggcgaaggtc      660

ggccggatcg acgaggcgct gcggatcttg gtgcgcatca atgggccgag tgctggtcaa      720

cgtgaactcg agtccattcg cgaatcgatt gcgagtgaaa gcgctgcaag catccgcgat      780

cttctgaaac ccggttggcg caaggcgctt ggtgtcggga ttcttcttgc gctgttcaat      840

caaatcatcg gcatgaacgc cgtgacgtat tacggccccg aaatcttcag gatggtgggg      900

ttcagtctca actccgattt cgagattcaa gcgttcttcg gcgccatgtg ggtcgtgttt      960

accgttgtcg cggtcgtcct gatcgatcgc gtcggcagaa agcccctgat gatcgtcggc     1020

tccgcgctga tggccatctt catggcgctg atgggcttga ccttttacct gcacgttcac     1080

aacgggttct ggctcgtgct cttcatcatg ggcttcacgg cggcgttcag cgtgtcgatg     1140

ggtccgattc cttggatcat gattccggaa atctttccga atcacctgcg cgcccgcgcg     1200

gccggcgtgg caaccatctt cctgtgggga gccaactggg ccatcggcca gtttacgcca     1260

gtattgctga acgatttcgg cggcgcctac accttctgga tgtttgcagt catcaacatc     1320

cttggggtgc tgttcgtcac ggcctgggtg ccggagacga aaaaccgttc cctggaggag     1380

atcgaatcca tctggatggc ttcggggcgc ggggtgtcga tttcgcaacg agacgcgcac     1440

gaacgcgcga agcgcgccca tttttga                                         1467


<210>   51
<211>   1467
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   51
atggccgacg tcgtgcccac accttggagg aggttcgcca tgtccactca gcagacacaa       60

ggctctcgcg cctacgcggt gaccatctcg ctggcggcag cgatgggagg gctgctctac      120

ggctacgata ccgcggtcat ttcgggagcc atcggtttct tgaaaacgct ctatcacctc      180

tcgcccttca tgcagggatt ggtcatctcg agcatcatga tcggcggcgt catcggcgtg      240

gccgtctccg gcttcttgag cgatcgcgtc ggccgccgca aggtcctcat gacggccgcc      300

gttctgttcg cggtggcggc gtttgtgtct gccatctcct ccgatgtcac cacgctcatt      360

cttgcgcgaa tcgtcggagg cctcggcatc ggcatgggat cggcgctctc ggtgacctac      420

atctccgagt gtgcgccgac gcagatccgc ggggcgctgt cgtcgctgta tcagctgctc      480

accttaatcg gcatctttct cacctatctc accaactact tgattcaacg ctccggatcg      540

gtcgcctggg acgtgcacac gggttggcgc tggatgctgg ggctgggctg cgtgccagcg      600

gctatcttct ttttcgtcct tctgtttgca cccgagagtc cgcggtggtt ggcgaaggtc      660

ggccggatcg acgaggcgct gcggatcttg gtgcgcatca atgggccgag tgctggtcaa      720

cgtgaactcg agtccattcg cgaatcgatt gcgagtgaaa gcgctgcaag catccgcgat      780

cttctgaaac ccggttggcg caaggcgctt ggtgtcggga ttcttcttgc gctgttcaat      840

caaatcatcg gcatgaacgc cgtgacgtat tacggccccg aaatcttcag gatggtgggg      900

ttcagtctca actccgattt cgagattcaa gcgttcttcg gcgccatgtg ggtcgtgttt      960

accgttgtcg cggtcgtcct gatcgatcgc gtcggcagaa agcccctgat gatcgtcggc     1020

tccgcgctga tggccatctt catggcgctg atgggcttga ccttttacct gcacgttcac     1080

aacgggttct ggctcgtgct cttcatcatg ggcttcacgg cggcgttcag cgtgtcgatg     1140

ggtccgattc cttggatcat gattccggaa atctttccga atcacctgcg cgcccgcgcg     1200

gccggcgtgg caaccatctt cctgtgggga gccaactggg ccatcggcca gtttacgcca     1260

gtattgctga acgatttcgg cggcgcctac accttctgga tgtttgcagt catcaacatc     1320

cttggggtgc tgttcgtcac ggcctgggtg ccggagacga aaaaccgttc cctggaggag     1380

atcgaatcca tctggatggc ttcggggcgc ggggtgtcgc tgtcgcaacg agacgcgcac     1440

gaacgcgcga agcgcgccca tttttga                                         1467


<210>   52
<211>   468
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   52
Met Gln Met Lys Ser Lys Val Lys Arg Trp Thr Ser Val Ala Leu Ala 
                5                   10                  15      

Ser Ser Ala Ala Ala Ala Leu Val Val Gly Cys Gly Gln Pro Asn Asn 
            20                  25                  30          

Thr Ala Ser Gln Thr Ser Thr Asn Gly Ser Ala Ser Thr Ala Ala Ser 
        35                  40                  45              

Ser Ala Ser Thr Val Ser Val Ala Gly Val Arg Ile Ala Lys Pro Thr 
    50                  55                  60                  

His Leu Val Asn Tyr Lys Asn Ala Ser Gly Thr Ile Val Trp Ala Glu 
65                  70                  75                  80  

Ser Phe Thr Thr Gly Pro Thr Ala Ser Glu Leu Val Ser Ala Phe Glu 
                85                  90                  95      

Lys Lys Tyr Pro Lys Ile Lys Val Lys Leu Gln Val Gln Pro Ser Asn 
            100                 105                 110         

Thr Asp Thr Asn Arg Ala Asp Leu Thr Ala Ser Ile Ser Gly Gly Ser 
        115                 120                 125             

Ser Thr Pro Asp Val Tyr Met Gly Asp Val Ile Trp Pro Ala Gln Phe 
    130                 135                 140                 

Ala His Asn Gln Leu Ala Ala Pro Leu Ser Asp Asp Leu Pro Thr Ser 
145                 150                 155                 160 

Phe Trp Thr Arg Phe Ser Asn Gly Leu Val Ala Gly Ala Thr Tyr Asn 
                165                 170                 175     

Gly Lys Val Tyr Ala Ala Pro Leu Phe Ala Asp Thr Ala Phe Leu Tyr 
            180                 185                 190         

Tyr Arg Lys Asp Leu Leu Ala Lys Tyr His Leu Pro Val Pro Lys Thr 
        195                 200                 205             

Trp Gln Gln Leu Gln Thr Glu Ala Ser Tyr Ile Val Lys His Gly Gly 
    210                 215                 220                 

Ala Lys Tyr Gly Phe Val Trp Gln Gly Ala Asp Tyr Glu Gly Leu Thr 
225                 230                 235                 240 

Cys Asp Phe Asp Glu Tyr Leu Ala Asp Ala Gly Gly Ser Val Leu Thr 
                245                 250                 255     

Asn Gly Lys Ala Thr Leu Asn Thr Ala Ala Ala Lys Gln Ala Leu Ser 
            260                 265                 270         

Phe Met Arg Gly Leu Ile Thr Ser Gly Ala Thr Pro Gln Ser Val Asp 
        275                 280                 285             

Thr Phe Gln Glu Pro Gln Ser Glu Asn Val Phe Thr Gln Gly Asn Ala 
    290                 295                 300                 

Val Phe Leu Arg Asn Trp Ser Tyr Ala Trp Ser Asp Ser Gln Asn Pro 
305                 310                 315                 320 

Gln Ser Ser Lys Val Val Gly Lys Val Gly Val Ala Pro Leu Pro Thr 
                325                 330                 335     

Phe Ala Gly His Gly Ser Ser Gly Tyr Ser Thr Val Gly Gly Trp Asp 
            340                 345                 350         

Leu Tyr Leu Asn Pro His Thr Lys Asn Leu Ala Ala Ala Leu Gln Phe 
        355                 360                 365             

Ile Asp Trp Met Thr Ser Pro Gln Ala Gln Glu Ile Leu Ala Ala Asn 
    370                 375                 380                 

Ser Glu Met Pro Thr Ile Lys Ala Val Ala Asp Ser Pro Ser Leu Ala 
385                 390                 395                 400 

Lys Tyr Ser Pro Val Phe Ala Leu Leu Pro Gln Val Lys Phe Val Ser 
                405                 410                 415     

Arg Pro Ala Gln Thr Pro Asn Tyr Pro Ala Val Ser Lys Ala Ile Tyr 
            420                 425                 430         

Asp Asn Val Asn Ala Ala Leu Ala Gly Ser Val Ser Val Ala Gln Ala 
        435                 440                 445             

Leu Lys Asn Ala Asn Gln Gln Ile Gln Gln Ala Leu Ser Gly Ser Gly 
    450                 455                 460                 

Ser Gly Gly Leu 
465             

<210>   53
<211>   1407
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   53
gtgcagatga agagcaaggt caagcgttgg acaagcgtcg cgctcgcgag ctcggcagcc       60

gcggcactgg tcgttggatg cggccagcca aacaacacgg cgtcccagac cagcacgaac      120

ggaagcgcat ccactgcggc gtcgtccgcc agcacggtga gcgtggccgg ggtgcggatc      180

gcgaagccga cccaccttgt gaactacaag aacgcctcgg gaacgattgt ctgggcggaa      240

tcgtttacca ctggccccac cgccagcgag ttggtctcgg cgtttgaaaa gaaatacccc      300

aagatcaaag tgaagttgca ggttcagccc tcgaacaccg acaccaaccg cgccgacctg      360

acggcgtcca tcagcggcgg atcttccacg ccggacgtct acatgggcga cgtgatctgg      420

cctgctcagt ttgcccacaa tcagttggcg gcgcctctct cggatgatct gcccacgtcc      480

ttctggacgc gcttttcgaa cggcttggtg gcaggagcca cgtataacgg aaaggtctac      540

gcggcgccgc tgtttgccga tacagcattc ctttattacc gcaaggacct gttggccaag      600

tatcatctgc ccgtgccgaa gacgtggcag caactgcaaa cggaggcttc ttacatcgtc      660

aagcacggtg gagcgaagta tgggttcgtc tggcagggcg ctgattacga ggggctcacc      720

tgcgacttcg acgagtacct ggcggatgca ggcggcagcg tgctgacgaa cggcaaagct      780

acactgaaca cagcggctgc gaaacaggca ctctcgttca tgcgagggct catcacgtcc      840

ggtgccacgc cccaatcggt ggacacgttc caggagcccc agtctgagaa tgtgttcacg      900

caagggaatg ccgtgttcct gcgcaactgg tcctacgcgt ggtcggattc ccagaatccg      960

caaagttcga aggtcgtggg caaggtcggc gtagcgcctc ttccgacatt tgctggacac     1020

ggctcgagcg gctacagcac ggtcggtggc tgggacctgt acctcaaccc gcacacgaag     1080

aatctggcag ccgcccttca gttcattgac tggatgacga gcccgcaggc tcaggaaatt     1140

ctggcggcca actcggagat gcccaccatc aaggctgtgg cggacagccc gtcgctcgcc     1200

aagtacagcc cggtgttcgc cctgttgcca caggtgaagt tcgtctcgcg gccggcgcag     1260

acaccgaact atccggcggt ctccaaggcc atttacgaca acgtcaacgc ggcgctggct     1320

ggcagtgtgt ctgtagcgca ggcgctgaag aacgcgaacc agcaaattca gcaggctctg     1380

agcggcagcg gttcgggcgg tctctga                                         1407


<210>   54
<211>   374
<212>   PRT
<213>   Saccharopolyspora erythraea NRRL 2338

<400>   54
Leu Val Asp Ala Phe Arg Ala Ala His Pro Asn Ile Thr Val Arg Ile 
                5                   10                  15      

Ala Gln Ala Pro Pro Thr Thr Asp Val Gln Arg Ala Thr Leu Thr Thr 
            20                  25                  30          

Gln Ile Ala Ser Gly Ala Pro Arg Pro Asp Val Tyr Leu Gly Asp Cys 
        35                  40                  45              

Val Trp Pro Ala Gln Phe Ala His Asn Ser Leu Ala Thr Pro Leu Asp 
    50                  55                  60                  

Thr Leu Val Glu Pro Gly Phe Trp Asp Asp Phe Ala Glu Pro Val Val 
65                  70                  75                  80  

Thr Ser Leu Thr Tyr Glu Asp Arg Arg Trp Ala Phe Pro Leu Tyr Leu 
                85                  90                  95      

Ser Glu Ser Phe Leu Tyr Tyr Arg Ala Asp Leu Leu Ala Lys His Gly 
            100                 105                 110         

Ile Ala Val Pro Arg Thr Trp Glu Glu Leu Thr Arg Ala Ala Arg Ala 
        115                 120                 125             

Leu Thr Ala Thr Gly Asp Val Arg Tyr Gly Leu Ser Trp Gln Ala Ala 
    130                 135                 140                 

Pro Ser Glu Thr Leu Thr Cys Asn Val Ala Glu Phe Val Ala Asp Ala 
145                 150                 155                 160 

Gly Gly Glu Leu Val Ala Pro Asp Tyr Ser Arg Ala Thr Leu Asp Ser 
                165                 170                 175     

Ala Ala Gly Arg Arg Ala Leu Gly Phe Val Glu Glu Leu Val Gly Thr 
            180                 185                 190         

Gly Val Ser Pro Arg Ser Val Ala Thr Phe Ser Glu Gln Glu Ser Leu 
        195                 200                 205             

Thr Thr Phe Thr Gly Gly Gln Ala Ala Phe Leu Arg Asn Trp Ala Tyr 
    210                 215                 220                 

Ala Trp Gly Thr Ala Gln Asp Pro Ser Asp Ser Gln Val Ser Gly Arg 
225                 230                 235                 240 

Ile Gly Ala Thr Phe Arg Pro Thr Phe Asp Gly Ala Thr Arg Ser Arg 
                245                 250                 255     

Val Ser Thr Val Gly Gly Trp His Asn Phe Val Asn Pro His Thr Glu 
            260                 265                 270         

Gln Leu Gly Ala Ala Val Ala Phe Ala Arg Trp Met Ser Gly Val Asp 
        275                 280                 285             

Ala Gln Leu Ile Leu Gly Met Arg Ser Thr Gln Leu Pro Ala Ser Leu 
    290                 295                 300                 

Thr Ala Val Asn Asp Pro Arg Ile Arg Gln Asn Asp Asn Pro Val Leu 
305                 310                 315                 320 

Arg Met Val Pro Glu Val Asp Leu Ala Pro Arg Pro Thr Arg Thr Pro 
                325                 330                 335     

Tyr Tyr Pro Gln Val Ser Glu Ala Val Tyr Ser Asn Ile Asn Pro Val 
            340                 345                 350         

Val Ala Gly Ser Ser Asp Pro Gly Ala Val Leu Ala Lys Val Ser Ser 
        355                 360                 365             

Glu Ile Asp Phe Ala Leu 
    370                 

<210>   55
<211>   385
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   55
Lys Asn Glu Pro Ile Thr Ile Thr Tyr Ser Thr Gly Lys Asp Ser Thr 
                5                   10                  15      

Pro Ala Thr Gln Lys Leu Val Glu Ala Phe Glu Lys Lys Tyr Pro Asn 
            20                  25                  30          

Ile Lys Val Lys Val Gln Glu Leu Pro Asn Ser Thr Asp Asp Gln His 
        35                  40                  45              

Asn Ser Tyr Val Thr Ala Leu Ser Ala Gly Asp Ser Ser Ile Asp Val 
    50                  55                  60                  

Leu Ala Met Asp Ile Ile Trp Thr Pro Glu Phe Ala Ala Ala Asn Trp 
65                  70                  75                  80  

Leu Leu Pro Leu Asp Asp Lys Phe Thr Lys Glu Met Arg Asp Lys Phe 
                85                  90                  95      

Leu Pro Gly Pro Val Glu Ala Val Thr Tyr Asn Gly His Val Trp Ala 
            100                 105                 110         

Val Pro Arg Phe Thr Asp Ala Gly Val Leu Tyr Tyr Arg Lys Asp Ile 
        115                 120                 125             

Ile Asp Thr Pro Pro Lys Thr Trp Asp Glu Leu Ile Gln Met Ala Lys 
    130                 135                 140                 

Glu Asn Val Gly Lys Gly Gly Thr Lys Tyr Gly Ile Val Phe Gln Gly 
145                 150                 155                 160 

Asn Gln Tyr Glu Gly Leu Val Cys Asp Ala Leu Glu Leu Ile Gly Ser 
                165                 170                 175     

Asn Gly Gly Ser Val Leu Glu Gly Asp Lys Val Thr Ile Asp Thr Pro 
            180                 185                 190         

Gln Ala Val Ala Gly Leu Gln Tyr Leu Ile Asp Leu Val Lys Ile Ala 
        195                 200                 205             

Pro Pro Gly Val Thr Thr Tyr Gln Glu Glu Asp Ala Arg Asn Val Phe 
    210                 215                 220                 

Gln Gln Gly Glu Ala Ile Phe Met Arg Asn Trp Pro Tyr Ala Trp Ser 
225                 230                 235                 240 

Leu Val Asn Gly Asp Asp Ser Pro Val Lys Gly Lys Val Gly Ile Ala 
                245                 250                 255     

Pro Ile Pro Arg Gly Lys Asp Gly Glu Val Gly Thr Pro Val Leu Gly 
            260                 265                 270         

Gly Trp Asn Leu Gly Ile Asn Lys Tyr Ser Lys His Pro Glu Glu Ala 
        275                 280                 285             

Trp Lys Phe Ile Glu Phe Val Thr Ser Glu Glu Gly Gln Lys Val Thr 
    290                 295                 300                 

Ala Leu Glu Gly Gly Asn Leu Pro Thr Ile Lys Ser Leu Tyr Gln Asp 
305                 310                 315                 320 

Lys Glu Val Leu Ala Lys Asn Pro Tyr Trp Ala Asp Phe Tyr Asp Val 
                325                 330                 335     

Phe Ile Thr Ala Lys Pro Arg Pro Val Ser Pro Phe Tyr Pro Gln Met 
            340                 345                 350         

Ser Asp Ser Met Gln Ile Asn Phe His Lys Ala Leu Thr Gly Glu Ile 
        355                 360                 365             

Thr Ala Gln Gln Ala Ile Gln Asn Ile Ala Lys Asp Leu Asn Asp Ile 
    370                 375                 380                 

Ile 
385 

<210>   56
<211>   387
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   56
Ile Val Tyr Ala Arg Gly Gln Asp Ser Thr Lys Ala Thr Glu Lys Ile 
                5                   10                  15      

Ile Glu Ala Phe Glu Lys Thr His Pro Asn Ile Asp Val Glu Phe Arg 
            20                  25                  30          

Glu Met Pro Ala Asp Thr Gly Lys Gln His Asp Ala Tyr Val Thr Met 
        35                  40                  45              

Leu Asn Ala Gln Ser Ser Glu Ile Asp Val Met Asp Leu Asp Val Ile 
    50                  55                  60                  

Trp Pro Ala Glu Phe Ala Gln Ala Gly Tyr Thr Leu Pro Leu Asp Arg 
65                  70                  75                  80  

Phe Ile Glu Lys Asp Gly Ile Asp Leu Gly Lys Tyr Asn Gln Gly Ala 
                85                  90                  95      

Leu Ala Ala Gly Asn Phe Asn Gly Lys Gln Trp Ala Met Pro Lys Phe 
            100                 105                 110         

Ile Asp Ala Gly Met Leu Phe Tyr Arg Thr Asp Leu Val Pro Lys Asp 
        115                 120                 125             

Lys Val Pro Lys Thr Trp Asp Glu Leu Leu Lys Glu Ala Lys Glu Leu 
    130                 135                 140                 

Lys Gly Lys Gly Gly Thr Lys Phe Gly Tyr Leu Met Gln Ala Lys Gln 
145                 150                 155                 160 

Tyr Glu Gly Leu Val Cys Asn Ala Val Glu Phe Ile Ala Ser Tyr Gly 
                165                 170                 175     

Gly Gln Ile Val Asp Lys Asn Gly Asn Val Val Ile Asn Ser Pro Glu 
            180                 185                 190         

Thr Ile Lys Gly Leu Lys Lys Met Val Glu Ile Val Lys Ser Asp Val 
        195                 200                 205             

Val Pro Ser Asn Ile Thr Thr Phe Thr Glu Pro Glu Ser His Thr Ala 
    210                 215                 220                 

Phe Ile Glu Gly Gln Ser Pro Phe Ile Arg Asn Trp Pro Tyr Gln Tyr 
225                 230                 235                 240 

Ala Leu Ala Asn Asp Lys Glu Gln Ser Lys Ile Val Gly Lys Val Gly 
                245                 250                 255     

Val Ala Pro Leu Pro Ala Gly Asp Lys Gly Ser Ala Ala Ala Leu Gly 
            260                 265                 270         

Gly Trp Met Thr Ala Ile Asn Lys Tyr Ser Lys His Pro Lys Glu Ala 
        275                 280                 285             

Trp Glu Phe Val Lys Phe Met Thr Gly Pro Glu Gly Gln Lys Ile Ser 
    290                 295                 300                 

Ala Ile Tyr Gly Gly Leu Ala Pro Thr Leu Pro Glu Leu Phe Lys Asp 
305                 310                 315                 320 

Pro Asp Val Leu Lys Ala Asn Pro Phe Phe Ala Glu Glu Gly Phe Val 
                325                 330                 335     

Asn Ala Leu Asn Ala Ala Val Pro Arg Pro Val Val Pro Asn Tyr Pro 
            340                 345                 350         

Glu Ile Ser Glu Ile Ile Gln Ile Asn Val Ser Lys Ala Leu Ala Gly 
        355                 360                 365             

Glu Leu Thr Val Glu Gln Ala Val Ala Asn Met Glu Lys Glu Met Lys 
    370                 375                 380                 

Ala Ala Leu 
385         

<210>   57
<211>   387
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   57
Ile Val Tyr Ala Arg Gly Gln Asp Ser Thr Lys Ala Thr Glu Lys Leu 
                5                   10                  15      

Ile Glu Ala Phe Glu Lys Ala His Pro Asn Ile Asp Val Glu Leu Arg 
            20                  25                  30          

Glu Met Pro Ala Asp Thr Gly Lys Gln His Asp Ala Tyr Val Thr Met 
        35                  40                  45              

Leu Asn Ala Gln Ser Ser Glu Ile Asp Val Met Asp Leu Asp Val Ile 
    50                  55                  60                  

Trp Pro Ala Glu Phe Ala Gln Ala Gly Tyr Thr Leu Pro Leu Asp Arg 
65                  70                  75                  80  

Phe Ile Glu Lys Asp Gly Ile Asp Leu Ser Lys Tyr Asn Gln Gly Ala 
                85                  90                  95      

Leu Ala Ala Gly Asn Phe Asn Gly Lys Gln Trp Ala Met Pro Lys Phe 
            100                 105                 110         

Ile Asp Thr Gly Met Leu Phe Tyr Arg Thr Asp Leu Val Pro Glu Asp 
        115                 120                 125             

Lys Val Pro Lys Thr Trp Asp Glu Leu Leu Lys Thr Ala Lys Glu Leu 
    130                 135                 140                 

Lys Gly Gln Gly Gly Thr Lys Phe Gly Tyr Leu Met Gln Ala Lys Gln 
145                 150                 155                 160 

Tyr Glu Gly Leu Val Cys Asn Ala Val Glu Phe Ile Ala Ser Tyr Gly 
                165                 170                 175     

Gly Gln Ile Val Asp Lys Asp Gly Asn Val Val Val Asn Ser Pro Glu 
            180                 185                 190         

Ala Ile Lys Gly Leu Lys Lys Met Val Glu Ile Val Gln Ser Asp Val 
        195                 200                 205             

Val Pro Ser Asn Val Thr Thr Phe Met Glu Pro Glu Ser His Thr Ala 
    210                 215                 220                 

Phe Ile Glu Gly Gln Ala Pro Phe Ile Arg Asn Trp Pro Tyr Gln Tyr 
225                 230                 235                 240 

Ala Leu Ala Asn Asp Gln Glu Gln Ser Lys Ile Val Gly Lys Val Ser 
                245                 250                 255     

Val Ala Pro Leu Pro Ala Gly Asp Lys Gly Ser Ala Ala Ala Leu Gly 
            260                 265                 270         

Gly Trp Met Thr Ala Ile Asn Lys Tyr Ser Lys His Pro Lys Glu Ala 
        275                 280                 285             

Trp Glu Phe Val Lys Phe Met Thr Gly Pro Glu Gly Gln Lys Ile Ser 
    290                 295                 300                 

Ala Val Tyr Gly Gly Leu Ala Pro Thr Leu Pro Glu Leu Tyr Glu Asp 
305                 310                 315                 320 

Glu Glu Val Leu Lys Ala Asn Pro Phe Phe Ala Glu Lys Gly Phe Val 
                325                 330                 335     

Asn Ala Leu Asn Ala Ala Val Pro Arg Pro Val Val Pro Asn Tyr Pro 
            340                 345                 350         

Glu Ile Ser Glu Ile Ile Gln Ile Asn Val Ser Lys Ala Leu Ala Gly 
        355                 360                 365             

Glu Leu Thr Val Glu Gln Ala Val Ala Asn Met Glu Lys Glu Met Lys 
    370                 375                 380                 

Ala Ala Met 
385         

<210>   58
<211>   389
<212>   PRT
<213>   Fervidobacterium nodosum Rt17-B1

<400>   58
Thr Met Thr Ala Gly Ala Val Gly Lys Glu Leu Glu Val Leu Tyr Ala 
                5                   10                  15      

Gln Leu Asp Arg Phe Met Lys Ala Asn Pro Asp Ile Lys Val Ser Val 
            20                  25                  30          

Met Pro Met Pro Asn Ser Ser Thr Glu Arg His Asp Leu Tyr Val Thr 
        35                  40                  45              

Tyr Leu Ala Ser Gly Glu Lys Glu Pro Thr Val Leu Met Leu Asp Val 
    50                  55                  60                  

Ile Trp Pro Ala Glu Phe Ala Pro Tyr Leu Glu Asp Leu Thr Ala Asp 
65                  70                  75                  80  

Lys Asp Tyr Phe Glu Leu Ser Lys Phe Leu Pro Gly Thr Val Lys Ala 
                85                  90                  95      

Ala Thr Val Gly Gly Lys Thr Val Ala Val Pro Trp Phe Thr Asp Ala 
            100                 105                 110         

Gly Leu Leu Tyr Tyr Arg Lys Asp Leu Leu Gln Lys Tyr Gly Phe Lys 
        115                 120                 125             

Glu Ala Pro Lys Thr Trp Asp Glu Leu Val Lys Met Ala Lys Thr Ile 
    130                 135                 140                 

Thr Ala Lys Glu Lys Asn Met Val Gly Phe Val Trp Gln Gly Ala Arg 
145                 150                 155                 160 

Tyr Glu Gly Leu Val Cys Asp Phe Met Glu Tyr Leu Val Ser Phe Gly 
                165                 170                 175     

Gly Asp Val Leu Asp Asp Ala Gly Asn Val Val Val Asn Ser Pro Ala 
            180                 185                 190         

Ala Val Lys Ala Leu Gln Phe Met Val Asp Leu Ile Tyr Lys Glu Lys 
        195                 200                 205             

Val Ser Pro Gln Ala Val Thr Thr Tyr Met Glu Glu Glu Ala Arg Arg 
    210                 215                 220                 

Lys Phe Gln Asn Gly Glu Ala Val Phe Met Arg Asn Trp Pro Tyr Ala 
225                 230                 235                 240 

Trp Ala Leu Leu Asn Asp Pro Lys Glu Ser Lys Val Ala Gly Lys Val 
                245                 250                 255     

Gly Val Ala Pro Leu Pro Ala Gly Pro Ser Gly Lys Ser Ala Ala Thr 
            260                 265                 270         

Leu Gly Gly Trp Met Leu Gly Ile Asn Lys Asn Ala Thr Pro Glu Glu 
        275                 280                 285             

Lys Ala Ala Ala Lys Lys Leu Val Lys Phe Leu Thr Ser Tyr Asp Glu 
    290                 295                 300                 

Gln Leu Tyr Lys Ala Ile Asn Ala Gly Gln Asn Pro Thr Met Met Asp 
305                 310                 315                 320 

Val Tyr Lys Asn Pro Glu Leu Lys Lys Ala Ala Pro Phe Met Val Glu 
                325                 330                 335     

Leu Tyr Gly Met Phe Ile Asn Ala Val Pro Arg Pro Arg Thr Ala Lys 
            340                 345                 350         

Tyr Ser Glu Ile Ser Asp Val Ile Gln Lys Tyr Val His Ala Ala Leu 
        355                 360                 365             

Thr Gln Gln Thr Thr Ala Gln Lys Ala Ile Glu Asp Met Ala Lys Glu 
    370                 375                 380                 

Leu Asn Lys Val Leu 
385                 

<210>   59
<211>   468
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   59
Met Gln Met Lys Ser Lys Val Lys Arg Trp Thr Ser Val Ala Leu Ala 
                5                   10                  15      

Ser Ser Ala Ala Ala Ala Leu Val Val Gly Cys Gly Gln Pro Asn Asn 
            20                  25                  30          

Thr Ala Ser Gln Thr Ser Thr Asn Gly Ser Ala Ser Thr Ala Ala Ser 
        35                  40                  45              

Ser Ala Ser Thr Val Ser Val Ala Gly Val Arg Ile Ala Lys Pro Thr 
    50                  55                  60                  

His Leu Val Asn Tyr Lys Asn Ala Ser Gly Thr Ile Val Trp Ala Glu 
65                  70                  75                  80  

Ser Phe Thr Thr Gly Pro Thr Ala Ser Glu Leu Val Ser Ala Phe Glu 
                85                  90                  95      

Lys Lys Tyr Pro Lys Ile Lys Val Lys Leu Gln Val Gln Pro Ser Asn 
            100                 105                 110         

Thr Asp Thr Asn Arg Ala Asp Leu Thr Ala Ser Ile Ser Gly Gly Ser 
        115                 120                 125             

Ser Thr Pro Asp Val Tyr Met Gly Asp Val Ile Trp Pro Ala Gln Phe 
    130                 135                 140                 

Ala His Asn Gln Leu Ala Ala Pro Leu Ser Asp Asp Leu Pro Thr Ser 
145                 150                 155                 160 

Phe Trp Thr Arg Phe Ser Asn Gly Leu Val Ala Gly Ala Thr Tyr Asn 
                165                 170                 175     

Gly Lys Val Tyr Ala Ala Pro Leu Phe Ala Asp Thr Ala Phe Leu Tyr 
            180                 185                 190         

Tyr Arg Lys Asp Leu Leu Ala Lys Tyr His Leu Pro Val Pro Lys Thr 
        195                 200                 205             

Trp Gln Gln Leu Gln Thr Glu Ala Ser Tyr Ile Val Lys His Gly Gly 
    210                 215                 220                 

Ala Lys Tyr Gly Phe Val Trp Gln Gly Ala Asp Tyr Glu Gly Leu Thr 
225                 230                 235                 240 

Cys Asp Phe Asp Glu Tyr Leu Ala Asp Ala Gly Gly Ser Val Leu Thr 
                245                 250                 255     

Asn Gly Lys Ala Thr Leu Asn Thr Ala Ala Ala Lys Gln Ala Leu Ser 
            260                 265                 270         

Phe Met Arg Gly Leu Leu Thr Ser Gly Ala Thr Pro Gln Ser Val Asp 
        275                 280                 285             

Thr Phe Gln Glu Pro Gln Ser Glu Asn Val Phe Thr Gln Gly Asn Ala 
    290                 295                 300                 

Val Phe Leu Arg Asn Trp Ser Tyr Ala Trp Ser Asp Ser Gln Asn Pro 
305                 310                 315                 320 

Gln Ser Ser Lys Val Val Gly Lys Val Gly Val Ala Pro Leu Pro Thr 
                325                 330                 335     

Phe Ala Gly His Gly Ser Ser Gly Tyr Ser Thr Val Gly Gly Trp Asp 
            340                 345                 350         

Leu Tyr Leu Asn Pro His Thr Lys Asn Leu Ala Ala Ala Leu Gln Phe 
        355                 360                 365             

Ile Asp Trp Met Thr Ser Pro Gln Ala Gln Glu Ile Leu Ala Ala Asn 
    370                 375                 380                 

Ser Glu Met Pro Thr Ile Lys Ala Val Ala Asp Ser Pro Ser Leu Ala 
385                 390                 395                 400 

Lys Tyr Ser Pro Val Phe Ala Leu Leu Pro Gln Val Lys Phe Val Ser 
                405                 410                 415     

Arg Pro Ala Gln Thr Pro Asn Tyr Pro Ala Val Ser Lys Ala Ile Tyr 
            420                 425                 430         

Asp Asn Val Asn Ala Ala Leu Ala Gly Ser Val Ser Val Ala Gln Ala 
        435                 440                 445             

Leu Lys Asn Ala Asn Gln Gln Ile Gln Gln Ala Leu Ser Gly Ser Gly 
    450                 455                 460                 

Ser Gly Gly Leu 
465             

<210>   60
<211>   468
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   60
Met Gln Met Lys Ser Lys Val Lys Arg Trp Thr Ser Val Ala Leu Ala 
                5                   10                  15      

Ser Ser Ala Ala Ala Ala Leu Val Val Gly Cys Gly Gln Pro Asn Asn 
            20                  25                  30          

Thr Ala Ser Gln Thr Ser Thr Asn Gly Ser Ala Ser Thr Ala Ala Ser 
        35                  40                  45              

Ser Ala Ser Thr Val Ser Val Ala Gly Val Arg Ile Ala Lys Pro Thr 
    50                  55                  60                  

His Leu Val Asn Tyr Lys Asn Ala Ser Gly Thr Ile Val Trp Ala Glu 
65                  70                  75                  80  

Ser Phe Thr Thr Gly Pro Thr Ala Ser Glu Leu Val Ser Ala Phe Glu 
                85                  90                  95      

Lys Lys Tyr Pro Lys Ile Lys Val Lys Leu Gln Val Gln Pro Ser Asn 
            100                 105                 110         

Thr Asp Thr Asn Arg Ala Asp Leu Thr Ala Ser Ile Ser Gly Gly Ser 
        115                 120                 125             

Ser Thr Pro Asp Val Tyr Met Gly Asp Val Ile Trp Pro Ala Gln Phe 
    130                 135                 140                 

Ala His Asn Gln Leu Ala Ala Pro Leu Ser Asp Asp Leu Pro Thr Ser 
145                 150                 155                 160 

Phe Trp Thr Arg Phe Ser Asn Gly Leu Val Ala Gly Ala Thr Tyr Asn 
                165                 170                 175     

Gly Lys Val Tyr Ala Ala Pro Leu Phe Ala Asp Thr Ala Phe Leu Tyr 
            180                 185                 190         

Tyr Arg Lys Asp Leu Leu Ala Lys Tyr His Leu Pro Val Pro Lys Thr 
        195                 200                 205             

Trp Gln Gln Leu Gln Thr Glu Ala Ser Tyr Ile Val Lys His Gly Gly 
    210                 215                 220                 

Ala Lys Tyr Gly Phe Val Trp Gln Gly Ala Asp Tyr Glu Gly Leu Thr 
225                 230                 235                 240 

Cys Asp Phe Asp Glu Tyr Leu Ala Asp Ala Gly Gly Ser Val Leu Thr 
                245                 250                 255     

Asn Gly Lys Ala Thr Leu Asn Thr Ala Ala Ala Lys Gln Ala Leu Ser 
            260                 265                 270         

Phe Met Arg Gly Leu Ile Thr Ser Gly Ala Thr Pro Gln Ser Val Asp 
        275                 280                 285             

Thr Phe Gln Glu Pro Gln Ser Glu Asn Val Phe Thr Gln Gly Asn Ala 
    290                 295                 300                 

Val Phe Leu Arg Asn Trp Ser Tyr Ala Trp Ser Asp Ser Gln Asn Pro 
305                 310                 315                 320 

Gln Ser Ser Lys Val Val Gly Lys Val Gly Val Ala Pro Leu Pro Thr 
                325                 330                 335     

Phe Ala Gly His Gly Ser Ser Gly Tyr Ser Thr Val Gly Gly Trp Asp 
            340                 345                 350         

Leu Tyr Leu Asn Pro His Thr Lys Asn Leu Ala Ala Ala Leu Gln Phe 
        355                 360                 365             

Ile Asp Trp Met Thr Ser Pro Gln Ala Gln Glu Ile Leu Ala Ala Asn 
    370                 375                 380                 

Ser Glu Met Pro Thr Ile Lys Ala Val Ala Asp Ser Pro Ser Leu Ala 
385                 390                 395                 400 

Lys Tyr Ser Pro Val Phe Ala Leu Leu Pro Gln Val Lys Phe Val Ser 
                405                 410                 415     

Arg Pro Ala Gln Thr Pro Asn Tyr Pro Ala Ile Ser Lys Ala Ile Tyr 
            420                 425                 430         

Asp Asn Val Asn Ala Ala Leu Ala Gly Ser Val Ser Val Ala Gln Ala 
        435                 440                 445             

Leu Lys Asn Ala Asn Gln Gln Ile Gln Gln Ala Leu Ser Gly Ser Gly 
    450                 455                 460                 

Ser Gly Gly Leu 
465             

<210>   61
<211>   468
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   61
Met Gln Met Lys Ser Lys Val Lys Arg Trp Thr Ser Val Ala Leu Ala 
                5                   10                  15      

Ser Ser Ala Ala Ala Ala Leu Val Val Gly Cys Gly Gln Pro Asn Asn 
            20                  25                  30          

Thr Ala Ser Gln Thr Ser Thr Asn Gly Ser Ala Ser Thr Ala Ala Ser 
        35                  40                  45              

Ser Ala Ser Thr Val Ser Val Ala Gly Val Arg Ile Ala Lys Pro Thr 
    50                  55                  60                  

His Leu Val Asn Tyr Lys Asn Ala Ser Gly Thr Ile Val Trp Ala Glu 
65                  70                  75                  80  

Ser Phe Thr Thr Gly Pro Thr Ala Ser Glu Leu Val Ser Ala Phe Glu 
                85                  90                  95      

Lys Lys Tyr Pro Lys Ile Lys Val Lys Leu Gln Val Gln Pro Ser Asn 
            100                 105                 110         

Thr Asp Thr Asn Arg Ala Asp Leu Thr Ala Ser Ile Ser Gly Gly Ser 
        115                 120                 125             

Ser Thr Pro Asp Val Tyr Met Gly Asp Val Ile Trp Pro Ala Gln Phe 
    130                 135                 140                 

Ala His Asn Gln Leu Ala Ala Pro Leu Ser Asp Asp Leu Pro Thr Ser 
145                 150                 155                 160 

Phe Trp Thr Arg Phe Ser Asn Gly Leu Val Ala Gly Ala Thr Tyr Asn 
                165                 170                 175     

Gly Lys Val Tyr Ala Ala Pro Leu Phe Ala Asp Thr Ala Phe Leu Tyr 
            180                 185                 190         

Tyr Arg Lys Asp Leu Leu Ala Lys Tyr His Leu Pro Val Pro Lys Thr 
        195                 200                 205             

Trp Gln Gln Leu Gln Thr Glu Ala Ser Tyr Ile Val Lys His Gly Gly 
    210                 215                 220                 

Ala Lys Tyr Gly Phe Val Trp Gln Gly Ala Asp Tyr Glu Gly Leu Thr 
225                 230                 235                 240 

Cys Asp Phe Asp Glu Tyr Leu Ala Asp Ala Gly Gly Ser Val Leu Thr 
                245                 250                 255     

Asn Gly Lys Ala Thr Leu Asn Thr Ala Ala Ala Lys Gln Ala Leu Ser 
            260                 265                 270         

Phe Met Arg Gly Leu Ile Thr Ser Gly Ala Thr Pro Gln Ser Val Asp 
        275                 280                 285             

Thr Phe Gln Glu Pro Gln Ser Glu Asn Val Phe Thr Gln Gly Asn Ala 
    290                 295                 300                 

Val Phe Leu Arg Asn Trp Ser Tyr Ala Trp Ser Asp Ser Gln Asn Pro 
305                 310                 315                 320 

Gln Ser Ser Lys Val Val Gly Lys Val Gly Val Ala Pro Leu Pro Thr 
                325                 330                 335     

Phe Ala Gly His Gly Ser Ser Gly Tyr Ser Thr Val Gly Gly Trp Asp 
            340                 345                 350         

Leu Tyr Leu Asn Pro His Thr Lys Asn Leu Ala Ala Ala Leu Gln Phe 
        355                 360                 365             

Ile Asp Trp Met Thr Ser Pro Gln Ala Gln Glu Ile Leu Ala Ala Asn 
    370                 375                 380                 

Ser Glu Met Pro Thr Ile Lys Ala Val Ala Asp Ser Pro Ser Leu Ala 
385                 390                 395                 400 

Lys Tyr Ser Pro Val Phe Ala Ile Leu Pro Gln Val Lys Phe Val Ser 
                405                 410                 415     

Arg Pro Ala Gln Thr Pro Asn Tyr Pro Ala Val Ser Lys Ala Ile Tyr 
            420                 425                 430         

Asp Asn Val Asn Ala Ala Leu Ala Gly Ser Val Ser Val Ala Gln Ala 
        435                 440                 445             

Leu Lys Asn Ala Asn Gln Gln Ile Gln Gln Ala Leu Ser Gly Ser Gly 
    450                 455                 460                 

Ser Gly Gly Leu 
465             

<210>   62
<211>   468
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   62
Met Gln Met Lys Ser Lys Val Lys Arg Trp Thr Ser Val Ala Leu Ala 
                5                   10                  15      

Ser Ser Ala Ala Ala Ala Leu Val Val Gly Cys Gly Gln Pro Asn Asn 
            20                  25                  30          

Thr Ala Ser Gln Thr Ser Thr Asn Gly Ser Ala Ser Thr Ala Ala Ser 
        35                  40                  45              

Ser Ala Ser Thr Val Ser Val Ala Gly Val Arg Ile Ala Lys Pro Thr 
    50                  55                  60                  

His Leu Val Asn Tyr Lys Asn Ala Ser Gly Thr Ile Val Trp Ala Glu 
65                  70                  75                  80  

Ser Phe Thr Thr Gly Pro Thr Ala Ser Glu Leu Val Ser Ala Phe Glu 
                85                  90                  95      

Lys Lys Tyr Pro Lys Ile Lys Val Lys Leu Gln Val Gln Pro Ser Asn 
            100                 105                 110         

Thr Asp Thr Asn Arg Ala Asp Leu Thr Ala Ser Ile Ser Gly Gly Ser 
        115                 120                 125             

Ser Thr Pro Asp Val Tyr Met Gly Asp Val Ile Trp Pro Ala Gln Phe 
    130                 135                 140                 

Ala His Asn Gln Leu Ala Ala Pro Leu Ser Asp Asp Leu Pro Thr Ser 
145                 150                 155                 160 

Phe Trp Thr Arg Phe Ser Asn Gly Leu Val Ala Gly Ala Thr Tyr Asn 
                165                 170                 175     

Gly Lys Val Tyr Ala Ala Pro Leu Phe Ala Asp Thr Ala Phe Leu Tyr 
            180                 185                 190         

Tyr Arg Lys Asp Leu Leu Ala Lys Tyr His Leu Pro Val Pro Lys Thr 
        195                 200                 205             

Trp Gln Gln Leu Gln Thr Glu Ala Ser Tyr Ile Val Lys His Gly Gly 
    210                 215                 220                 

Ala Lys Tyr Gly Phe Val Trp Gln Gly Ala Asp Tyr Glu Gly Leu Thr 
225                 230                 235                 240 

Cys Asp Phe Asp Glu Tyr Leu Ala Asp Ala Gly Gly Ser Val Leu Thr 
                245                 250                 255     

Gln Gly Lys Ala Thr Leu Asn Thr Ala Ala Ala Lys Gln Ala Leu Ser 
            260                 265                 270         

Phe Met Arg Gly Leu Ile Thr Ser Gly Ala Thr Pro Gln Ser Val Asp 
        275                 280                 285             

Thr Phe Gln Glu Pro Gln Ser Glu Asn Val Phe Thr Gln Gly Asn Ala 
    290                 295                 300                 

Val Phe Leu Arg Asn Trp Ser Tyr Ala Trp Ser Asp Ser Gln Asn Pro 
305                 310                 315                 320 

Gln Ser Ser Lys Val Val Gly Lys Val Gly Val Ala Pro Leu Pro Thr 
                325                 330                 335     

Phe Ala Gly His Gly Ser Ser Gly Tyr Ser Thr Val Gly Gly Trp Asp 
            340                 345                 350         

Leu Tyr Leu Asn Pro His Thr Lys Asn Leu Ala Ala Ala Leu Gln Phe 
        355                 360                 365             

Ile Asp Trp Met Thr Ser Pro Gln Ala Gln Glu Ile Leu Ala Ala Asn 
    370                 375                 380                 

Ser Glu Met Pro Thr Ile Lys Ala Val Ala Asp Ser Pro Ser Leu Ala 
385                 390                 395                 400 

Lys Tyr Ser Pro Val Phe Ala Leu Leu Pro Gln Val Lys Phe Val Ser 
                405                 410                 415     

Arg Pro Ala Gln Thr Pro Asn Tyr Pro Ala Val Ser Lys Ala Ile Tyr 
            420                 425                 430         

Asp Asn Val Asn Ala Ala Leu Ala Gly Ser Val Ser Val Ala Gln Ala 
        435                 440                 445             

Leu Lys Asn Ala Asn Gln Gln Ile Gln Gln Ala Leu Ser Gly Ser Gly 
    450                 455                 460                 

Ser Gly Gly Leu 
465             

<210>   63
<211>   468
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   63
Met Gln Met Lys Ser Lys Val Lys Arg Trp Thr Ser Val Ala Leu Ala 
                5                   10                  15      

Ser Ser Ala Ala Ala Ala Leu Val Val Gly Cys Gly Gln Pro Asn Asn 
            20                  25                  30          

Thr Ala Ser Gln Thr Ser Thr Asn Gly Ser Ala Ser Thr Ala Ala Ser 
        35                  40                  45              

Ser Ala Ser Thr Val Ser Val Ala Gly Val Arg Ile Ala Lys Pro Thr 
    50                  55                  60                  

His Leu Val Asn Tyr Lys Asn Ala Ser Gly Thr Ile Val Trp Ala Glu 
65                  70                  75                  80  

Ser Phe Thr Thr Gly Pro Thr Ala Ser Glu Leu Val Ser Ala Phe Glu 
                85                  90                  95      

Lys Lys Tyr Pro Lys Ile Lys Val Lys Leu Gln Val Gln Pro Ser Asn 
            100                 105                 110         

Thr Asp Thr Asn Arg Ala Asp Leu Thr Ala Ser Ile Ser Gly Gly Ser 
        115                 120                 125             

Ser Thr Pro Asp Val Tyr Met Gly Asp Val Ile Trp Pro Ala Gln Phe 
    130                 135                 140                 

Ala His Asn Gln Leu Ala Ala Pro Leu Ser Asp Asp Leu Pro Thr Ser 
145                 150                 155                 160 

Phe Trp Thr Arg Phe Ser Asn Gly Leu Val Ala Gly Ala Thr Tyr Asn 
                165                 170                 175     

Gly Lys Val Tyr Ala Ala Pro Leu Phe Ala Asp Thr Ala Phe Leu Tyr 
            180                 185                 190         

Tyr Arg Lys Asp Leu Leu Ala Lys Tyr His Leu Pro Val Pro Lys Thr 
        195                 200                 205             

Trp Gln Gln Leu Gln Thr Glu Ala Ser Tyr Ile Val Lys His Gly Gly 
    210                 215                 220                 

Ala Lys Tyr Gly Phe Val Trp Gln Gly Ala Asp Tyr Glu Gly Leu Thr 
225                 230                 235                 240 

Cys Asp Phe Asp Glu Tyr Leu Ala Asp Ala Gly Gly Ser Val Leu Thr 
                245                 250                 255     

Asn Gly Lys Ala Thr Leu Asn Thr Ala Ala Ala Lys Gln Ala Leu Ser 
            260                 265                 270         

Phe Met Arg Gly Leu Ile Thr Ser Gly Ala Thr Pro Gln Ser Val Asp 
        275                 280                 285             

Thr Phe Gln Glu Pro Gln Ser Glu Asn Val Phe Thr Gln Gly Asn Ala 
    290                 295                 300                 

Val Phe Leu Arg Asn Trp Ser Tyr Ala Trp Ser Asp Ser Gln Asn Pro 
305                 310                 315                 320 

Gln Ser Ser Lys Val Val Gly Lys Val Gly Val Ala Pro Leu Pro Thr 
                325                 330                 335     

Phe Ala Gly His Gly Ser Ser Gly Tyr Ser Thr Val Gly Gly Trp Asp 
            340                 345                 350         

Leu Tyr Leu Asn Pro His Thr Lys Asn Leu Ala Ala Ala Leu Gln Phe 
        355                 360                 365             

Ile Asp Trp Met Thr Ser Pro Gln Ala Gln Glu Ile Leu Ala Ala Gln 
    370                 375                 380                 

Ser Glu Met Pro Thr Ile Lys Ala Val Ala Asp Ser Pro Ser Leu Ala 
385                 390                 395                 400 

Lys Tyr Ser Pro Val Phe Ala Leu Leu Pro Gln Val Lys Phe Val Ser 
                405                 410                 415     

Arg Pro Ala Gln Thr Pro Asn Tyr Pro Ala Val Ser Lys Ala Ile Tyr 
            420                 425                 430         

Asp Asn Val Asn Ala Ala Leu Ala Gly Ser Val Ser Val Ala Gln Ala 
        435                 440                 445             

Leu Lys Asn Ala Asn Gln Gln Ile Gln Gln Ala Leu Ser Gly Ser Gly 
    450                 455                 460                 

Ser Gly Gly Leu 
465             

<210>   64
<211>   1407
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   64
gtgcagatga agagcaaggt caagcgttgg acaagcgtcg cgctcgcgag ctcggcagcc       60

gcggcactgg tcgttggatg cggccagcca aacaacacgg cgtcccagac cagcacgaac      120

ggaagcgcat ccactgcggc gtcgtccgcc agcacggtga gcgtggccgg ggtgcggatc      180

gcgaagccga cccaccttgt gaactacaag aacgcctcgg gaacgattgt ctgggcggaa      240

tcgtttacca ctggccccac cgccagcgag ttggtctcgg cgtttgaaaa gaaatacccc      300

aagatcaaag tgaagttgca ggttcagccc tcgaacaccg acaccaaccg cgccgacctg      360

acggcgtcca tcagcggcgg atcttccacg ccggacgtct acatgggcga cgtgatctgg      420

cctgctcagt ttgcccacaa tcagttggcg gcgcctctct cggatgatct gcccacgtcc      480

ttctggacgc gcttttcgaa cggcttggtg gcaggagcca cgtataacgg aaaggtctac      540

gcggcgccgc tgtttgccga tacagcattc ctttattacc gcaaggacct gttggccaag      600

tatcatctgc ccgtgccgaa gacgtggcag caactgcaaa cggaggcttc ttacatcgtc      660

aagcacggtg gagcgaagta tgggttcgtc tggcagggcg ctgattacga ggggctcacc      720

tgcgacttcg acgagtacct ggcggatgca ggcggcagcg tgctgacgaa cggcaaagct      780

acactgaaca cagcggctgc gaaacaggca ctctcgttca tgcgagggct cttaacgtcc      840

ggtgccacgc cccaatcggt ggacacgttc caggagcccc agtctgagaa tgtgttcacg      900

caagggaatg ccgtgttcct gcgcaactgg tcctacgcgt ggtcggattc ccagaatccg      960

caaagttcga aggtcgtggg caaggtcggc gtagcgcctc ttccgacatt tgctggacac     1020

ggctcgagcg gctacagcac ggtcggtggc tgggacctgt acctcaaccc gcacacgaag     1080

aatctggcag ccgcccttca gttcattgac tggatgacga gcccgcaggc tcaggaaatt     1140

ctggcggcca actcggagat gcccaccatc aaggctgtgg cggacagccc gtcgctcgcc     1200

aagtacagcc cggtgttcgc cctgttgcca caggtgaagt tcgtctcgcg gccggcgcag     1260

acaccgaact atccggcggt ctccaaggcc atttacgaca acgtcaacgc ggcgctggct     1320

ggcagtgtgt ctgtagcgca ggcgctgaag aacgcgaacc agcaaattca gcaggctctg     1380

agcggcagcg gttcgggcgg tctctga                                         1407


<210>   65
<211>   1407
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   65
gtgcagatga agagcaaggt caagcgttgg acaagcgtcg cgctcgcgag ctcggcagcc       60

gcggcactgg tcgttggatg cggccagcca aacaacacgg cgtcccagac cagcacgaac      120

ggaagcgcat ccactgcggc gtcgtccgcc agcacggtga gcgtggccgg ggtgcggatc      180

gcgaagccga cccaccttgt gaactacaag aacgcctcgg gaacgattgt ctgggcggaa      240

tcgtttacca ctggccccac cgccagcgag ttggtctcgg cgtttgaaaa gaaatacccc      300

aagatcaaag tgaagttgca ggttcagccc tcgaacaccg acaccaaccg cgccgacctg      360

acggcgtcca tcagcggcgg atcttccacg ccggacgtct acatgggcga cgtgatctgg      420

cctgctcagt ttgcccacaa tcagttggcg gcgcctctct cggatgatct gcccacgtcc      480

ttctggacgc gcttttcgaa cggcttggtg gcaggagcca cgtataacgg aaaggtctac      540

gcggcgccgc tgtttgccga tacagcattc ctttattacc gcaaggacct gttggccaag      600

tatcatctgc ccgtgccgaa gacgtggcag caactgcaaa cggaggcttc ttacatcgtc      660

aagcacggtg gagcgaagta tgggttcgtc tggcagggcg ctgattacga ggggctcacc      720

tgcgacttcg acgagtacct ggcggatgca ggcggcagcg tgctgacgaa cggcaaagct      780

acactgaaca cagcggctgc gaaacaggca ctctcgttca tgcgagggct catcacgtcc      840

ggtgccacgc cccaatcggt ggacacgttc caggagcccc agtctgagaa tgtgttcacg      900

caagggaatg ccgtgttcct gcgcaactgg tcctacgcgt ggtcggattc ccagaatccg      960

caaagttcga aggtcgtggg caaggtcggc gtagcgcctc ttccgacatt tgctggacac     1020

ggctcgagcg gctacagcac ggtcggtggc tgggacctgt acctcaaccc gcacacgaag     1080

aatctggcag ccgcccttca gttcattgac tggatgacga gcccgcaggc tcaggaaatt     1140

ctggcggcca actcggagat gcccaccatc aaggctgtgg cggacagccc gtcgctcgcc     1200

aagtacagcc cggtgttcgc cctgttgcca caggtgaagt tcgtctcgcg gccggcgcag     1260

acaccgaact atccggcgat ttccaaggcc atttacgaca acgtcaacgc ggcgctggct     1320

ggcagtgtgt ctgtagcgca ggcgctgaag aacgcgaacc agcaaattca gcaggctctg     1380

agcggcagcg gttcgggcgg tctctga                                         1407


<210>   66
<211>   1407
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   66
gtgcagatga agagcaaggt caagcgttgg acaagcgtcg cgctcgcgag ctcggcagcc       60

gcggcactgg tcgttggatg cggccagcca aacaacacgg cgtcccagac cagcacgaac      120

ggaagcgcat ccactgcggc gtcgtccgcc agcacggtga gcgtggccgg ggtgcggatc      180

gcgaagccga cccaccttgt gaactacaag aacgcctcgg gaacgattgt ctgggcggaa      240

tcgtttacca ctggccccac cgccagcgag ttggtctcgg cgtttgaaaa gaaatacccc      300

aagatcaaag tgaagttgca ggttcagccc tcgaacaccg acaccaaccg cgccgacctg      360

acggcgtcca tcagcggcgg atcttccacg ccggacgtct acatgggcga cgtgatctgg      420

cctgctcagt ttgcccacaa tcagttggcg gcgcctctct cggatgatct gcccacgtcc      480

ttctggacgc gcttttcgaa cggcttggtg gcaggagcca cgtataacgg aaaggtctac      540

gcggcgccgc tgtttgccga tacagcattc ctttattacc gcaaggacct gttggccaag      600

tatcatctgc ccgtgccgaa gacgtggcag caactgcaaa cggaggcttc ttacatcgtc      660

aagcacggtg gagcgaagta tgggttcgtc tggcagggcg ctgattacga ggggctcacc      720

tgcgacttcg acgagtacct ggcggatgca ggcggcagcg tgctgacgaa cggcaaagct      780

acactgaaca cagcggctgc gaaacaggca ctctcgttca tgcgagggct catcacgtcc      840

ggtgccacgc cccaatcggt ggacacgttc caggagcccc agtctgagaa tgtgttcacg      900

caagggaatg ccgtgttcct gcgcaactgg tcctacgcgt ggtcggattc ccagaatccg      960

caaagttcga aggtcgtggg caaggtcggc gtagcgcctc ttccgacatt tgctggacac     1020

ggctcgagcg gctacagcac ggtcggtggc tgggacctgt acctcaaccc gcacacgaag     1080

aatctggcag ccgcccttca gttcattgac tggatgacga gcccgcaggc tcaggaaatt     1140

ctggcggcca actcggagat gcccaccatc aaggctgtgg cggacagccc gtcgctcgcc     1200

aagtacagcc cggtgttcgc cattttgcca caggtgaagt tcgtctcgcg gccggcgcag     1260

acaccgaact atccggcggt ctccaaggcc atttacgaca acgtcaacgc ggcgctggct     1320

ggcagtgtgt ctgtagcgca ggcgctgaag aacgcgaacc agcaaattca gcaggctctg     1380

agcggcagcg gttcgggcgg tctctga                                         1407


<210>   67
<211>   1407
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   67
gtgcagatga agagcaaggt caagcgttgg acaagcgtcg cgctcgcgag ctcggcagcc       60

gcggcactgg tcgttggatg cggccagcca aacaacacgg cgtcccagac cagcacgaac      120

ggaagcgcat ccactgcggc gtcgtccgcc agcacggtga gcgtggccgg ggtgcggatc      180

gcgaagccga cccaccttgt gaactacaag aacgcctcgg gaacgattgt ctgggcggaa      240

tcgtttacca ctggccccac cgccagcgag ttggtctcgg cgtttgaaaa gaaatacccc      300

aagatcaaag tgaagttgca ggttcagccc tcgaacaccg acaccaaccg cgccgacctg      360

acggcgtcca tcagcggcgg atcttccacg ccggacgtct acatgggcga cgtgatctgg      420

cctgctcagt ttgcccacaa tcagttggcg gcgcctctct cggatgatct gcccacgtcc      480

ttctggacgc gcttttcgaa cggcttggtg gcaggagcca cgtataacgg aaaggtctac      540

gcggcgccgc tgtttgccga tacagcattc ctttattacc gcaaggacct gttggccaag      600

tatcatctgc ccgtgccgaa gacgtggcag caactgcaaa cggaggcttc ttacatcgtc      660

aagcacggtg gagcgaagta tgggttcgtc tggcagggcg ctgattacga ggggctcacc      720

tgcgacttcg acgagtacct ggcggatgca ggcggcagcg tgctgacgca aggcaaagct      780

acactgaaca cagcggctgc gaaacaggca ctctcgttca tgcgagggct catcacgtcc      840

ggtgccacgc cccaatcggt ggacacgttc caggagcccc agtctgagaa tgtgttcacg      900

caagggaatg ccgtgttcct gcgcaactgg tcctacgcgt ggtcggattc ccagaatccg      960

caaagttcga aggtcgtggg caaggtcggc gtagcgcctc ttccgacatt tgctggacac     1020

ggctcgagcg gctacagcac ggtcggtggc tgggacctgt acctcaaccc gcacacgaag     1080

aatctggcag ccgcccttca gttcattgac tggatgacga gcccgcaggc tcaggaaatt     1140

ctggcggcca actcggagat gcccaccatc aaggctgtgg cggacagccc gtcgctcgcc     1200

aagtacagcc cggtgttcgc cctgttgcca caggtgaagt tcgtctcgcg gccggcgcag     1260

acaccgaact atccggcggt ctccaaggcc atttacgaca acgtcaacgc ggcgctggct     1320

ggcagtgtgt ctgtagcgca ggcgctgaag aacgcgaacc agcaaattca gcaggctctg     1380

agcggcagcg gttcgggcgg tctctga                                         1407


<210>   68
<211>   1407
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   68
gtgcagatga agagcaaggt caagcgttgg acaagcgtcg cgctcgcgag ctcggcagcc       60

gcggcactgg tcgttggatg cggccagcca aacaacacgg cgtcccagac cagcacgaac      120

ggaagcgcat ccactgcggc gtcgtccgcc agcacggtga gcgtggccgg ggtgcggatc      180

gcgaagccga cccaccttgt gaactacaag aacgcctcgg gaacgattgt ctgggcggaa      240

tcgtttacca ctggccccac cgccagcgag ttggtctcgg cgtttgaaaa gaaatacccc      300

aagatcaaag tgaagttgca ggttcagccc tcgaacaccg acaccaaccg cgccgacctg      360

acggcgtcca tcagcggcgg atcttccacg ccggacgtct acatgggcga cgtgatctgg      420

cctgctcagt ttgcccacaa tcagttggcg gcgcctctct cggatgatct gcccacgtcc      480

ttctggacgc gcttttcgaa cggcttggtg gcaggagcca cgtataacgg aaaggtctac      540

gcggcgccgc tgtttgccga tacagcattc ctttattacc gcaaggacct gttggccaag      600

tatcatctgc ccgtgccgaa gacgtggcag caactgcaaa cggaggcttc ttacatcgtc      660

aagcacggtg gagcgaagta tgggttcgtc tggcagggcg ctgattacga ggggctcacc      720

tgcgacttcg acgagtacct ggcggatgca ggcggcagcg tgctgacgaa cggcaaagct      780

acactgaaca cagcggctgc gaaacaggca ctctcgttca tgcgagggct catcacgtcc      840

ggtgccacgc cccaatcggt ggacacgttc caggagcccc agtctgagaa tgtgttcacg      900

caagggaatg ccgtgttcct gcgcaactgg tcctacgcgt ggtcggattc ccagaatccg      960

caaagttcga aggtcgtggg caaggtcggc gtagcgcctc ttccgacatt tgctggacac     1020

ggctcgagcg gctacagcac ggtcggtggc tgggacctgt acctcaaccc gcacacgaag     1080

aatctggcag ccgcccttca gttcattgac tggatgacga gcccgcaggc tcaggaaatt     1140

ctggcggccc aatcggagat gcccaccatc aaggctgtgg cggacagccc gtcgctcgcc     1200

aagtacagcc cggtgttcgc cctgttgcca caggtgaagt tcgtctcgcg gccggcgcag     1260

acaccgaact atccggcggt ctccaaggcc atttacgaca acgtcaacgc ggcgctggct     1320

ggcagtgtgt ctgtagcgca ggcgctgaag aacgcgaacc agcaaattca gcaggctctg     1380

agcggcagcg gttcgggcgg tctctga                                         1407


<210>   69
<211>   330
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   69
Met Ser Thr Met Leu Ala Ser Glu Gly Glu Gly Arg Arg Ala Arg Met 
                5                   10                  15      

Ser Lys Ala Met Glu Gly His Ala Ser Phe Gln Thr Asp Gly Arg Arg 
            20                  25                  30          

Ala Ser Val Val Arg His Asp Val Arg Ala Gly Phe Gly Met Leu Thr 
        35                  40                  45              

Pro Ala Gly Ile Val Ile Leu Ala Val Thr Ile Phe Pro Ile Leu Tyr 
    50                  55                  60                  

Ser Val Trp Met Ser Phe Asn Asn Ile Gln Leu Thr Glu Asn Gly Phe 
65                  70                  75                  80  

Gln Phe Thr Phe Asn Gly Ile Gln Asn Tyr Val Asp Val Tyr Ser Ala 
                85                  90                  95      

Pro Leu Phe Trp His Ser Val Trp Phe Thr Val Tyr Tyr Ser Ile Val 
            100                 105                 110         

Thr Val Ala Ile Glu Leu Phe Leu Gly Leu Leu Ile Ala Leu Ala Ile 
        115                 120                 125             

Gln Asn Val Glu Lys Leu Lys Ser Val Ser Val Val Val Met Leu Ile 
    130                 135                 140                 

Pro Trp Ser Leu Ile Thr Val Ile Ser Ala Glu Met Trp Ser Tyr Ile 
145                 150                 155                 160 

Tyr Asn Gly Val Tyr Gly Val Leu Asn Ala Ile Leu Gln Gly Leu Gly 
                165                 170                 175     

Phe Ile His Ser Pro Ile Asn Trp Thr Gly Glu Pro Val Thr Ala Val 
            180                 185                 190         

Ile Ala Leu Met Ala Ala Asp Ile Trp Lys Thr Thr Pro Phe Val Val 
        195                 200                 205             

Ile Ile Leu Leu Ser Gly Leu Gln Met Ile Pro Lys Asp Tyr Tyr Glu 
    210                 215                 220                 

Ala Ala Arg Ile Asp Gly Ala Asn Gly Trp Gln Ile Phe Trp Asn Val 
225                 230                 235                 240 

Thr Phe Pro Gln Leu Arg Gly Ser Ile Ala Ile Ala Gly Leu Phe Arg 
                245                 250                 255     

Ile Leu Gln Ala Phe Gly Ile Phe Asp Leu Pro Phe Val Leu Thr Gln 
            260                 265                 270         

Gly Gly Pro Gly Ser Thr Thr Thr Ser Leu Ala Met Leu Gly Glu Glu 
        275                 280                 285             

Thr Leu Phe Thr Asn Leu His Phe Gly Leu Gly Ala Ala Val Ala Val 
    290                 295                 300                 

Ser Thr Val Ile Leu Ile Leu Gly Ala Cys Leu Ile Phe Leu Ser Ala 
305                 310                 315                 320 

Phe Arg Gly Met Val Gly Glu Glu Ala Gln 
                325                 330 

<210>   70
<211>   993
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   70
gtgtctacga tgctcgcaag cgaaggagaa gggaggcgag cgcgcatgtc aaaggcgatg       60

gaagggcatg catcgtttca aaccgatggc aggcgagcga gcgtcgttcg ccacgacgtt      120

cgcgcgggct ttgggatgtt gaccccagcc ggcattgtca tcctggccgt gaccattttc      180

cccatcctct attccgtgtg gatgagcttc aataacattc aattgacgga gaacggattt      240

cagttcacgt tcaacggcat tcaaaactac gtcgacgtct attccgcccc cctgttctgg      300

cacagtgtgt ggttcacggt gtattactcg attgtcacgg tcgcgatcga gttgtttttg      360

gggctgctca ttgcgcttgc catccagaac gtggagaaat tgaagagcgt ctcggtcgtg      420

gtgatgctca ttccttggtc gctcatcacg gtcatttccg ccgagatgtg gagttacatc      480

tacaacggcg tgtatggcgt cctgaacgcc atcctccaag gactgggttt catccacagc      540

cccatcaact ggaccggtga gccggtgacg gctgtgatcg ccctcatggc agcggatatt      600

tggaaaacta caccgtttgt cgtcatcatc ctgttgagcg ggctgcagat gatcccgaaa      660

gactactacg aggcggcgcg catcgacggc gcgaacggtt ggcagatctt ttggaacgtc      720

acgtttcctc agttgcgggg aagcatcgcc atcgcgggcc tgtttcgaat tcttcaggcg      780

ttcggtatct tcgacctgcc gttcgtgctc acgcagggtg gccctggttc gacgaccacg      840

tccctcgcca tgctgggtga ggaaacgctg ttcacgaacc ttcactttgg cttgggagca      900

gcggtcgccg tcagcacggt gatcctcatc ttaggggctt gtctaatatt cctgtccgcc      960

tttcgcggga tggtcgggga ggaagcgcaa tga                                   993


<210>   71
<211>   286
<212>   PRT
<213>   Saccharopolyspora erythraea NRRL 2338

<400>   71
Arg Leu Gly Trp Leu Tyr Thr Ala Pro Ala Leu Ile Val Val Val Ala 
                5                   10                  15      

Val Thr Ile Phe Pro Ile Leu Phe Ser Val Val Leu Ser Phe Thr Arg 
            20                  25                  30          

Val Arg Val Thr Tyr Gly Gly Phe Arg Val Glu Glu Leu Thr Leu Asp 
        35                  40                  45              

Asn Tyr Val Ala Leu Phe Gln Ser Ser Glu Trp His Tyr Ala Val Leu 
    50                  55                  60                  

Phe Thr Phe Phe Tyr Thr Val Val Thr Val Thr Ile Glu Leu Val Leu 
65                  70                  75                  80  

Gly Val Leu Ala Ala Leu Val Leu Glu Arg Leu Gly Ala Ala Arg Gly 
                85                  90                  95      

Trp Val Leu Ala Leu Leu Leu Ile Pro Trp Ser Met Ile Thr Val Ile 
            100                 105                 110         

Ser Ala Gln Leu Trp Ala Phe Ile Tyr Asn Ser Thr Tyr Gly Val Ala 
        115                 120                 125             

Thr Trp Leu Leu Glu Ala Leu Phe Gly Thr Ala Pro Ile Ile Leu Gly 
    130                 135                 140                 

Thr Pro Val Pro Ala Ile Thr Gly Met Met Val Ala Asp Ile Trp Lys 
145                 150                 155                 160 

Thr Thr Pro Phe Val Thr Ile Ile Val Leu Ala Gly Leu Val Met Leu 
                165                 170                 175     

Ser Arg Glu Val Tyr Glu Ser Ala Glu Ile Asp Gly Ala Asn Ala Trp 
            180                 185                 190         

Thr Thr Phe Trp Arg Val Thr Leu Pro Gln Leu Lys Ser Thr Leu Ala 
        195                 200                 205             

Val Ala Val Leu Phe Arg Ile Leu Gln Ala Phe Gly Val Phe Asp Leu 
    210                 215                 220                 

Pro Phe Val Leu Thr Thr Gly Gly Pro Gly Thr Ala Thr Gln Ser Leu 
225                 230                 235                 240 

Ala Ile Leu Gly Tyr Lys Thr Leu Phe Gln Asp Leu His Ile Gly Pro 
                245                 250                 255     

Gly Ala Ala Ile Ala Thr Ser Thr Gly Leu Leu Val Ile Gly Gly Cys 
            260                 265                 270         

Leu Leu Phe Leu Lys Ala Phe Arg Ala Gln Val Gly Lys Glu 
        275                 280                 285     

<210>   72
<211>   277
<212>   PRT
<213>   Cyanothece sp. CCY0110

<400>   72
Met Arg Glu Glu Asn Lys Thr Ala Trp Phe Met Leu Ile Pro Ala Leu 
                5                   10                  15      

Ala Val Leu Ala Phe Val Phe Ala Tyr Pro Ile Gly Arg Ala Phe Trp 
            20                  25                  30          

Leu Ser Leu Phe Thr Glu Asn Leu Gly Thr Gln Leu Gln Pro Val Phe 
        35                  40                  45              

Ser Gly Phe Thr Asn Tyr Leu Arg Met Ala Gly Asp Gly Arg Phe Trp 
    50                  55                  60                  

Gln Ser Met Trp Asn Thr Trp Val Phe Thr Gly Val Ser Val Phe Leu 
65                  70                  75                  80  

Glu Leu Val Leu Gly Met Ile Val Ala Leu Val Leu Asn Gln Ala Phe 
                85                  90                  95      

Phe Cys Arg Gly Ala Val Arg Thr Ile Ser Met Ile Pro Trp Ala Leu 
            100                 105                 110         

Pro Thr Ala Ile Met Gly Leu Ala Trp Ala Trp Ile Phe Asn Asp Gln 
        115                 120                 125             

Tyr Gly Val Val Asn Asp Ile Leu Gln Arg Leu Gly Ile Ile Asn Thr 
    130                 135                 140                 

Glu Ile Asn Trp Leu Gly Asp Pro Thr Leu Ala Met Ile Ala Leu Ile 
145                 150                 155                 160 

Val Ala Asp Val Trp Lys Thr Thr Pro Phe Ile Ser Ile Ile Leu Leu 
                165                 170                 175     

Ala Gly Leu Gln Ser Ile Pro Lys Asp Leu Tyr Glu Ala His Ser Leu 
            180                 185                 190         

Asp Gly Ala Asn Pro Trp Gln Ser Phe Tyr Gln Ile Thr Leu Pro Leu 
        195                 200                 205             

Val Met Pro Gln Val Leu Ile Ala Leu Leu Phe Arg Phe Ala Gln Ala 
    210                 215                 220                 

Phe Gly Ile Phe Asp Leu Val Gln Val Met Thr Gly Gly Gly Pro Ala 
225                 230                 235                 240 

Gly Ala Thr Glu Thr Val Ser Ile Tyr Ile Tyr Ser Thr Val Met Arg 
                245                 250                 255     

Tyr Leu Asp Phe Gly Tyr Gly Ala Ala Leu Val Val Ile Thr Phe Leu 
            260                 265                 270         

Leu Leu Ile Ala Ala 
        275         

<210>   73
<211>   275
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   73
Gly Tyr Ile Leu Val Ala Pro Ala Leu Leu Cys Ile Ile Ala Ile Ala 
                5                   10                  15      

Leu Tyr Pro Val Leu Asn Thr Phe Lys Leu Ser Leu Tyr Tyr Met Lys 
            20                  25                  30          

Leu Gln Leu Pro Gly Leu Thr His Phe Val Gly Leu Gln Asn Tyr Ile 
        35                  40                  45              

Thr Leu Ser Ser Asp Ser Arg Phe Trp Ser Ala Thr Leu Asn Thr Val 
    50                  55                  60                  

Phe Phe Thr Val Val Ser Val Ala Leu Glu Leu Val Leu Gly Met Ile 
65                  70                  75                  80  

Met Ala Leu Leu Met Asn Lys Lys Phe Lys Gly Ile Gly Leu Val Arg 
                85                  90                  95      

Ala Ala Val Leu Ile Pro Trp Ala Ile Pro Thr Val Ile Ser Ala Leu 
            100                 105                 110         

Met Trp Lys Phe Ile Tyr Asn Asp Gln Phe Gly Val Leu Asn Asp Ile 
        115                 120                 125             

Leu Met Lys Val Gly Leu Ile Asn Ser Tyr Lys Ala Trp Leu Gly Ser 
    130                 135                 140                 

Pro Ser Ser Ala Met Ser Ala Ala Ile Phe Ala Asp Val Trp Lys Thr 
145                 150                 155                 160 

Ala Pro Phe Met Ala Leu Leu Leu Leu Ala Gly Leu Gln Asn Ile Ser 
                165                 170                 175     

Gln Asp Leu Tyr Glu Ala Ala Lys Val Asp Gly Ala Gly Ser Ile Arg 
            180                 185                 190         

Gln Phe Phe Arg Ile Thr Leu Pro Leu Leu Lys Pro Thr Ile Leu Val 
        195                 200                 205             

Ala Leu Ile Phe Arg Thr Leu Asp Ala Phe Arg Val Phe Asp Leu Ile 
    210                 215                 220                 

Phe Val Met Thr Gly Gly Gly Pro Gly Asn Ser Thr Glu Thr Leu Ser 
225                 230                 235                 240 

Ile Tyr Ala Tyr Lys Thr Leu Phe Arg Asn Leu Asp Phe Gly Ile Gly 
                245                 250                 255     

Ser Ala Ile Ala Val Ile Ile Phe Ile Phe Val Phe Ile Phe Ala Met 
            260                 265                 270         

Phe Tyr Ile 
        275 

<210>   74
<211>   269
<212>   PRT
<213>   Synechococcus elongatus PCC 6301

<400>   74
Pro Ala Leu Leu Thr Ile Thr Gly Val Phe Ala Tyr Pro Leu Leu Arg 
                5                   10                  15      

Ala Ala Trp Leu Ser Leu Gln Ala Leu Asn Leu Asn Thr Gln Leu Gln 
            20                  25                  30          

Pro Val Phe Ile Gly Leu Ala Asn Tyr Gln Arg Leu Trp Gly Asp Ser 
        35                  40                  45              

Arg Phe Trp Gly Asp Leu Phe Asn Thr Thr Val Phe Thr Val Thr Ser 
    50                  55                  60                  

Val Ser Leu Glu Leu Val Leu Gly Leu Ala Ile Ala Leu Leu Leu His 
65                  70                  75                  80  

Gln Pro Ser Arg Trp Arg Gly Pro Leu Arg Thr Ile Ala Leu Leu Pro 
                85                  90                  95      

Trp Val Leu Pro Thr Ala Val Met Ala Leu Gly Trp Ala Trp Ile Phe 
            100                 105                 110         

Asn Asp Pro Tyr Gly Val Trp Asn Asp Trp Leu Gln Gln Leu Gly Trp 
        115                 120                 125             

Ile Ala Ala Pro Ile Asn Trp Leu Gly Asn Pro Arg Trp Ala Trp Leu 
    130                 135                 140                 

Thr Leu Val Ala Ala Asp Val Trp Lys Thr Thr Pro Phe Val Ala Ile 
145                 150                 155                 160 

Leu Leu Leu Ala Gly Arg Gln Ala Ile Pro Glu Asp Leu Tyr Glu Ala 
                165                 170                 175     

His Cys Leu Glu Gly Ala Thr Ala Trp Gln Ser Phe Trp Gln Ile Thr 
            180                 185                 190         

Leu Pro Leu Leu Arg Pro Gln Leu Ala Ile Ala Leu Leu Phe Arg Ser 
        195                 200                 205             

Ala Gln Ala Phe Gly Leu Phe Asp Leu Val Lys Val Met Thr Gly Gly 
    210                 215                 220                 

Gly Pro Ala Asn Ser Thr Glu Thr Leu Ala Leu Tyr Ala Tyr Thr Thr 
225                 230                 235                 240 

Ala Leu Arg Tyr Leu Asp Phe Gly Tyr Gly Ala Thr Leu Ala Ile Val 
                245                 250                 255     

Thr Ala Ala Ile Leu Ala Ala Gly Leu Gly Leu Ile Trp 
            260                 265                 

<210>   75
<211>   294
<212>   PRT
<213>   Nocardioides sp. JS614

<400>   75
Gly Arg Arg Leu Arg Val Arg Gly Gly Gln His Glu Gly Arg Phe Ala 
                5                   10                  15      

Leu Leu Leu Leu Leu Pro Ala Ala Val Val Val Phe Gly Val Val Leu 
            20                  25                  30          

Trp Pro Val Val Arg Thr Leu Val Val Ser Leu Tyr Asp Val Asp Ser 
        35                  40                  45              

Ala Met Pro Gly Ser Tyr Pro Phe Val Gly Leu Asp Asn Tyr Val Arg 
    50                  55                  60                  

Val Phe Gln Asp Asp Arg Phe Tyr Ser Val Leu Gly His Thr Met Tyr 
65                  70                  75                  80  

Phe Thr Leu Val Ser Thr Phe Leu Glu Leu Ala Leu Gly Ile Ala Val 
                85                  90                  95      

Ala Leu Leu Leu Asn Ala Pro Leu Lys Ala Arg Trp Leu Trp Arg Ser 
            100                 105                 110         

Ile Val Val Leu Pro Trp Ala Leu Pro Thr Ile Val Asn Gly Ala Leu 
        115                 120                 125             

Trp Arg Trp Ile Tyr Asn Gly Gln Tyr Gly Ala Leu Asn Gly Leu Leu 
    130                 135                 140                 

Asp Thr Leu Gly Ile Ser Glu Thr Pro Thr Gln Trp Leu Gly Glu Pro 
145                 150                 155                 160 

Phe Leu Ala Leu Asn Met Val Ile Ile Ala Asp Val Trp Lys Asn Thr 
                165                 170                 175     

Ser Ile Val Val Phe Phe Ile Leu Ala Gly Leu Gln Thr Ile Pro Ser 
            180                 185                 190         

Asp Leu Tyr Glu Ala Ala Arg Val Asp Gly Ala Gly Pro Trp Arg Ala 
        195                 200                 205             

Phe Trp Arg Leu Thr Ile Pro Met Leu Ala Pro Ser Ile Ala Val Val 
    210                 215                 220                 

Leu Ile Leu Arg Thr Ile Glu Ala Phe Lys Val Phe Asp Ile Ile Tyr 
225                 230                 235                 240 

Val Met Thr Gly Gly Gly Pro Ala Ser Gly Thr Gln Thr Ile Ala Phe 
                245                 250                 255     

Tyr Thr Tyr Leu Gln Ala Phe Ser Asn Gln Leu Phe Gly Tyr Gly Ala 
            260                 265                 270         

Ala Leu Ala Tyr Leu Ile Val Leu Ala Val Phe Ala Leu Ala Met Ala 
        275                 280                 285             

Tyr Leu Arg Ile Leu Arg 
    290                 

<210>   76
<211>   330
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   76
Met Ser Thr Met Leu Ala Ser Glu Gly Glu Gly Arg Arg Ala Arg Met 
                5                   10                  15      

Ser Lys Ala Met Glu Gly His Ala Ser Phe Gln Thr Asp Gly Arg Arg 
            20                  25                  30          

Ala Ser Val Val Arg His Asp Val Arg Ala Gly Phe Gly Met Leu Thr 
        35                  40                  45              

Pro Ala Gly Ile Val Ile Leu Ala Val Thr Ile Phe Pro Ile Leu Tyr 
    50                  55                  60                  

Ser Val Trp Met Ser Phe Asn Asn Ile Gln Leu Thr Glu Asn Gly Phe 
65                  70                  75                  80  

Gln Phe Thr Phe Asn Gly Ile Gln Asn Tyr Val Asp Val Tyr Ser Ala 
                85                  90                  95      

Pro Leu Phe Trp His Ser Val Trp Phe Thr Val Tyr Tyr Ser Ile Val 
            100                 105                 110         

Thr Val Ala Ile Glu Leu Phe Leu Gly Leu Leu Ile Ala Leu Ala Ile 
        115                 120                 125             

Gln Asn Val Glu Lys Leu Lys Ser Val Ser Val Val Val Met Leu Ile 
    130                 135                 140                 

Pro Trp Ser Leu Ile Thr Val Ile Ser Ala Glu Met Trp Ser Tyr Ile 
145                 150                 155                 160 

Tyr Asn Gly Val Tyr Gly Val Leu Asn Ala Ile Leu Gln Gly Leu Gly 
                165                 170                 175     

Phe Ile His Ser Pro Ile Asn Trp Thr Gly Glu Pro Val Thr Ala Val 
            180                 185                 190         

Ile Ala Leu Met Ala Ala Asp Ile Trp Lys Thr Thr Pro Phe Val Val 
        195                 200                 205             

Ile Ile Leu Leu Ser Gly Leu Gln Met Ile Pro Lys Asp Tyr Tyr Glu 
    210                 215                 220                 

Ala Ala Arg Ile Asp Gly Ala Asn Gly Trp Gln Ile Phe Trp Asn Val 
225                 230                 235                 240 

Thr Phe Pro Gln Leu Arg Gly Ser Ile Ala Leu Ala Gly Leu Phe Arg 
                245                 250                 255     

Ile Leu Gln Ala Phe Gly Ile Phe Asp Leu Pro Phe Val Leu Thr Gln 
            260                 265                 270         

Gly Gly Pro Gly Ser Thr Thr Thr Ser Leu Ala Met Leu Gly Glu Glu 
        275                 280                 285             

Thr Leu Phe Thr Asn Leu His Phe Gly Leu Gly Ala Ala Val Ala Val 
    290                 295                 300                 

Ser Thr Val Ile Leu Ile Leu Gly Ala Cys Leu Ile Phe Leu Ser Ala 
305                 310                 315                 320 

Phe Arg Gly Met Val Gly Glu Glu Ala Gln 
                325                 330 

<210>   77
<211>   330
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   77
Met Ser Thr Met Leu Ala Ser Glu Gly Glu Gly Arg Arg Ala Arg Met 
                5                   10                  15      

Ser Lys Ala Met Glu Gly His Ala Ser Phe Gln Thr Asp Gly Arg Arg 
            20                  25                  30          

Ala Ser Val Val Arg His Asp Val Arg Ala Gly Phe Gly Met Leu Thr 
        35                  40                  45              

Pro Ala Gly Ile Val Ile Leu Ala Val Thr Ile Phe Pro Ile Leu Tyr 
    50                  55                  60                  

Ser Val Trp Met Ser Phe Asn Asn Ile Gln Leu Thr Glu Asn Gly Phe 
65                  70                  75                  80  

Gln Phe Thr Phe Asn Gly Ile Gln Asn Tyr Val Asp Val Tyr Ser Ala 
                85                  90                  95      

Pro Leu Phe Trp His Ser Val Trp Phe Thr Val Tyr Tyr Ser Ile Val 
            100                 105                 110         

Thr Val Ala Leu Glu Leu Phe Leu Gly Leu Leu Ile Ala Leu Ala Ile 
        115                 120                 125             

Gln Asn Val Glu Lys Leu Lys Ser Val Ser Val Val Val Met Leu Ile 
    130                 135                 140                 

Pro Trp Ser Leu Ile Thr Val Ile Ser Ala Glu Met Trp Ser Tyr Ile 
145                 150                 155                 160 

Tyr Asn Gly Val Tyr Gly Val Leu Asn Ala Ile Leu Gln Gly Leu Gly 
                165                 170                 175     

Phe Ile His Ser Pro Ile Asn Trp Thr Gly Glu Pro Val Thr Ala Val 
            180                 185                 190         

Ile Ala Leu Met Ala Ala Asp Ile Trp Lys Thr Thr Pro Phe Val Val 
        195                 200                 205             

Ile Ile Leu Leu Ser Gly Leu Gln Met Ile Pro Lys Asp Tyr Tyr Glu 
    210                 215                 220                 

Ala Ala Arg Ile Asp Gly Ala Asn Gly Trp Gln Ile Phe Trp Asn Val 
225                 230                 235                 240 

Thr Phe Pro Gln Leu Arg Gly Ser Ile Ala Ile Ala Gly Leu Phe Arg 
                245                 250                 255     

Ile Leu Gln Ala Phe Gly Ile Phe Asp Leu Pro Phe Val Leu Thr Gln 
            260                 265                 270         

Gly Gly Pro Gly Ser Thr Thr Thr Ser Leu Ala Met Leu Gly Glu Glu 
        275                 280                 285             

Thr Leu Phe Thr Asn Leu His Phe Gly Leu Gly Ala Ala Val Ala Val 
    290                 295                 300                 

Ser Thr Val Ile Leu Ile Leu Gly Ala Cys Leu Ile Phe Leu Ser Ala 
305                 310                 315                 320 

Phe Arg Gly Met Val Gly Glu Glu Ala Gln 
                325                 330 

<210>   78
<211>   330
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   78
Met Ser Thr Met Leu Ala Ser Glu Gly Glu Gly Arg Arg Ala Arg Met 
                5                   10                  15      

Ser Lys Ala Met Glu Gly His Ala Ser Phe Gln Thr Asp Gly Arg Arg 
            20                  25                  30          

Ala Ser Val Val Arg His Asp Val Arg Ala Gly Phe Gly Met Leu Thr 
        35                  40                  45              

Pro Ala Gly Ile Val Ile Leu Ala Val Thr Ile Phe Pro Ile Leu Tyr 
    50                  55                  60                  

Ser Val Trp Met Ser Phe Asn Asn Ile Gln Leu Thr Glu Asn Gly Phe 
65                  70                  75                  80  

Gln Phe Thr Phe Asn Gly Ile Gln Asn Tyr Val Asp Val Tyr Ser Ala 
                85                  90                  95      

Pro Leu Phe Trp His Ser Val Trp Phe Thr Ile Tyr Tyr Ser Ile Val 
            100                 105                 110         

Thr Val Ala Ile Glu Leu Phe Leu Gly Leu Leu Ile Ala Leu Ala Ile 
        115                 120                 125             

Gln Asn Val Glu Lys Leu Lys Ser Val Ser Val Val Val Met Leu Ile 
    130                 135                 140                 

Pro Trp Ser Leu Ile Thr Val Ile Ser Ala Glu Met Trp Ser Tyr Ile 
145                 150                 155                 160 

Tyr Asn Gly Val Tyr Gly Val Leu Asn Ala Ile Leu Gln Gly Leu Gly 
                165                 170                 175     

Phe Ile His Ser Pro Ile Asn Trp Thr Gly Glu Pro Val Thr Ala Val 
            180                 185                 190         

Ile Ala Leu Met Ala Ala Asp Ile Trp Lys Thr Thr Pro Phe Val Val 
        195                 200                 205             

Ile Ile Leu Leu Ser Gly Leu Gln Met Ile Pro Lys Asp Tyr Tyr Glu 
    210                 215                 220                 

Ala Ala Arg Ile Asp Gly Ala Asn Gly Trp Gln Ile Phe Trp Asn Val 
225                 230                 235                 240 

Thr Phe Pro Gln Leu Arg Gly Ser Ile Ala Ile Ala Gly Leu Phe Arg 
                245                 250                 255     

Ile Leu Gln Ala Phe Gly Ile Phe Asp Leu Pro Phe Val Leu Thr Gln 
            260                 265                 270         

Gly Gly Pro Gly Ser Thr Thr Thr Ser Leu Ala Met Leu Gly Glu Glu 
        275                 280                 285             

Thr Leu Phe Thr Asn Leu His Phe Gly Leu Gly Ala Ala Val Ala Val 
    290                 295                 300                 

Ser Thr Val Ile Leu Ile Leu Gly Ala Cys Leu Ile Phe Leu Ser Ala 
305                 310                 315                 320 

Phe Arg Gly Met Val Gly Glu Glu Ala Gln 
                325                 330 

<210>   79
<211>   330
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   79
Met Ser Thr Met Leu Ala Ser Glu Gly Glu Gly Arg Arg Ala Arg Met 
                5                   10                  15      

Ser Lys Ala Met Glu Gly His Ala Ser Phe Gln Thr Asp Gly Arg Arg 
            20                  25                  30          

Ala Ser Val Val Arg His Asp Val Arg Ala Gly Phe Gly Met Leu Thr 
        35                  40                  45              

Pro Ala Gly Ile Val Ile Leu Ala Val Thr Ile Phe Pro Ile Leu Tyr 
    50                  55                  60                  

Ser Val Trp Met Ser Phe Asn Asn Ile Gln Leu Thr Glu Asn Gly Phe 
65                  70                  75                  80  

Gln Phe Thr Phe Asn Gly Ile Gln Asn Tyr Val Asp Val Tyr Ser Ala 
                85                  90                  95      

Pro Leu Phe Trp His Ser Val Trp Phe Thr Val Tyr Tyr Ser Ile Val 
            100                 105                 110         

Thr Val Ala Ile Glu Leu Phe Leu Gly Leu Leu Ile Ala Leu Ala Ile 
        115                 120                 125             

Gln Asn Val Glu Lys Leu Lys Ser Val Ser Val Val Val Met Leu Ile 
    130                 135                 140                 

Pro Trp Ser Leu Ile Thr Val Ile Ser Ala Glu Met Trp Ser Tyr Ile 
145                 150                 155                 160 

Tyr Asn Gly Val Tyr Gly Val Leu Asn Ala Ile Leu Gln Gly Leu Gly 
                165                 170                 175     

Phe Ile His Ser Pro Ile Asn Trp Thr Gly Glu Pro Val Thr Ala Val 
            180                 185                 190         

Ile Ala Leu Met Ala Ala Asp Ile Trp Lys Thr Thr Pro Phe Val Val 
        195                 200                 205             

Ile Ile Leu Leu Ser Gly Leu Gln Met Ile Pro Lys Asp Tyr Tyr Glu 
    210                 215                 220                 

Ala Ala Arg Ile Asp Gly Ala Asn Gly Trp Gln Ile Phe Trp Asn Val 
225                 230                 235                 240 

Thr Phe Pro Gln Leu Arg Gly Ser Ile Ala Ile Ala Gly Leu Phe Arg 
                245                 250                 255     

Ile Leu Gln Ala Phe Gly Ile Phe Asp Leu Pro Phe Val Ile Thr Gln 
            260                 265                 270         

Gly Gly Pro Gly Ser Thr Thr Thr Ser Leu Ala Met Leu Gly Glu Glu 
        275                 280                 285             

Thr Leu Phe Thr Asn Leu His Phe Gly Leu Gly Ala Ala Val Ala Val 
    290                 295                 300                 

Ser Thr Val Ile Leu Ile Leu Gly Ala Cys Leu Ile Phe Leu Ser Ala 
305                 310                 315                 320 

Phe Arg Gly Met Val Gly Glu Glu Ala Gln 
                325                 330 

<210>   80
<211>   330
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   80
Met Ser Thr Met Leu Ala Ser Glu Gly Glu Gly Arg Arg Ala Arg Met 
                5                   10                  15      

Ser Lys Ala Met Glu Gly His Ala Ser Phe Gln Thr Asp Gly Arg Arg 
            20                  25                  30          

Ala Ser Val Val Arg His Asp Val Arg Ala Gly Phe Gly Met Leu Thr 
        35                  40                  45              

Pro Ala Gly Ile Val Ile Leu Ala Val Thr Ile Phe Pro Ile Leu Tyr 
    50                  55                  60                  

Ser Val Trp Met Ser Phe Asn Asn Ile Gln Leu Thr Glu Asn Gly Phe 
65                  70                  75                  80  

Gln Phe Thr Phe Asn Gly Ile Gln Asn Tyr Val Asp Val Tyr Ser Ala 
                85                  90                  95      

Pro Leu Phe Trp His Ser Val Trp Phe Thr Val Tyr Tyr Ser Ile Val 
            100                 105                 110         

Thr Val Ala Ile Glu Leu Phe Leu Gly Leu Leu Ile Ala Leu Ala Ile 
        115                 120                 125             

Gln Asn Val Glu Lys Leu Lys Ser Val Ser Val Val Val Met Leu Ile 
    130                 135                 140                 

Pro Trp Ser Leu Ile Thr Val Ile Ser Ala Glu Met Trp Ser Tyr Ile 
145                 150                 155                 160 

Tyr Asn Gly Val Tyr Gly Val Leu Asn Ala Ile Leu Gln Gly Leu Gly 
                165                 170                 175     

Phe Ile His Ser Pro Ile Asn Trp Thr Gly Glu Pro Val Thr Ala Val 
            180                 185                 190         

Ile Ala Leu Met Ala Ala Asp Ile Trp Lys Thr Thr Pro Phe Val Val 
        195                 200                 205             

Ile Ile Leu Leu Ser Gly Leu Gln Met Ile Pro Lys Asp Tyr Tyr Glu 
    210                 215                 220                 

Ala Ala Arg Ile Glu Gly Ala Asn Gly Trp Gln Ile Phe Trp Asn Val 
225                 230                 235                 240 

Thr Phe Pro Gln Leu Arg Gly Ser Ile Ala Ile Ala Gly Leu Phe Arg 
                245                 250                 255     

Ile Leu Gln Ala Phe Gly Ile Phe Asp Leu Pro Phe Val Leu Thr Gln 
            260                 265                 270         

Gly Gly Pro Gly Ser Thr Thr Thr Ser Leu Ala Met Leu Gly Glu Glu 
        275                 280                 285             

Thr Leu Phe Thr Asn Leu His Phe Gly Leu Gly Ala Ala Val Ala Val 
    290                 295                 300                 

Ser Thr Val Ile Leu Ile Leu Gly Ala Cys Leu Ile Phe Leu Ser Ala 
305                 310                 315                 320 

Phe Arg Gly Met Val Gly Glu Glu Ala Gln 
                325                 330 

<210>   81
<211>   993
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   81
gtgtctacga tgctcgcaag cgaaggagaa gggaggcgag cgcgcatgtc aaaggcgatg       60

gaagggcatg catcgtttca aaccgatggc aggcgagcga gcgtcgttcg ccacgacgtt      120

cgcgcgggct ttgggatgtt gaccccagcc ggcattgtca tcctggccgt gaccattttc      180

cccatcctct attccgtgtg gatgagcttc aataacattc aattgacgga gaacggattt      240

cagttcacgt tcaacggcat tcaaaactac gtcgacgtct attccgcccc cctgttctgg      300

cacagtgtgt ggttcacggt gtattactcg attgtcacgg tcgcgatcga gttgtttttg      360

gggctgctca ttgcgcttgc catccagaac gtggagaaat tgaagagcgt ctcggtcgtg      420

gtgatgctca ttccttggtc gctcatcacg gtcatttccg ccgagatgtg gagttacatc      480

tacaacggcg tgtatggcgt cctgaacgcc atcctccaag gactgggttt catccacagc      540

cccatcaact ggaccggtga gccggtgacg gctgtgatcg ccctcatggc agcggatatt      600

tggaaaacta caccgtttgt cgtcatcatc ctgttgagcg ggctgcagat gatcccgaaa      660

gactactacg aggcggcgcg catcgacggc gcgaacggtt ggcagatctt ttggaacgtc      720

acgtttcctc agttgcgggg aagcatcgcc ttagcgggcc tgtttcgaat tcttcaggcg      780

ttcggtatct tcgacctgcc gttcgtgctc acgcagggtg gccctggttc gacgaccacg      840

tccctcgcca tgctgggtga ggaaacgctg ttcacgaacc ttcactttgg cttgggagca      900

gcggtcgccg tcagcacggt gatcctcatc ttaggggctt gtctaatatt cctgtccgcc      960

tttcgcggga tggtcgggga ggaagcgcaa tga                                   993


<210>   82
<211>   993
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   82
gtgtctacga tgctcgcaag cgaaggagaa gggaggcgag cgcgcatgtc aaaggcgatg       60

gaagggcatg catcgtttca aaccgatggc aggcgagcga gcgtcgttcg ccacgacgtt      120

cgcgcgggct ttgggatgtt gaccccagcc ggcattgtca tcctggccgt gaccattttc      180

cccatcctct attccgtgtg gatgagcttc aataacattc aattgacgga gaacggattt      240

cagttcacgt tcaacggcat tcaaaactac gtcgacgtct attccgcccc cctgttctgg      300

cacagtgtgt ggttcacggt gtattactcg attgtcacgg tcgcgttaga gttgtttttg      360

gggctgctca ttgcgcttgc catccagaac gtggagaaat tgaagagcgt ctcggtcgtg      420

gtgatgctca ttccttggtc gctcatcacg gtcatttccg ccgagatgtg gagttacatc      480

tacaacggcg tgtatggcgt cctgaacgcc atcctccaag gactgggttt catccacagc      540

cccatcaact ggaccggtga gccggtgacg gctgtgatcg ccctcatggc agcggatatt      600

tggaaaacta caccgtttgt cgtcatcatc ctgttgagcg ggctgcagat gatcccgaaa      660

gactactacg aggcggcgcg catcgacggc gcgaacggtt ggcagatctt ttggaacgtc      720

acgtttcctc agttgcgggg aagcatcgcc atcgcgggcc tgtttcgaat tcttcaggcg      780

ttcggtatct tcgacctgcc gttcgtgctc acgcagggtg gccctggttc gacgaccacg      840

tccctcgcca tgctgggtga ggaaacgctg ttcacgaacc ttcactttgg cttgggagca      900

gcggtcgccg tcagcacggt gatcctcatc ttaggggctt gtctaatatt cctgtccgcc      960

tttcgcggga tggtcgggga ggaagcgcaa tga                                   993


<210>   83
<211>   993
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   83
gtgtctacga tgctcgcaag cgaaggagaa gggaggcgag cgcgcatgtc aaaggcgatg       60

gaagggcatg catcgtttca aaccgatggc aggcgagcga gcgtcgttcg ccacgacgtt      120

cgcgcgggct ttgggatgtt gaccccagcc ggcattgtca tcctggccgt gaccattttc      180

cccatcctct attccgtgtg gatgagcttc aataacattc aattgacgga gaacggattt      240

cagttcacgt tcaacggcat tcaaaactac gtcgacgtct attccgcccc cctgttctgg      300

cacagtgtgt ggttcacgat ttattactcg attgtcacgg tcgcgatcga gttgtttttg      360

gggctgctca ttgcgcttgc catccagaac gtggagaaat tgaagagcgt ctcggtcgtg      420

gtgatgctca ttccttggtc gctcatcacg gtcatttccg ccgagatgtg gagttacatc      480

tacaacggcg tgtatggcgt cctgaacgcc atcctccaag gactgggttt catccacagc      540

cccatcaact ggaccggtga gccggtgacg gctgtgatcg ccctcatggc agcggatatt      600

tggaaaacta caccgtttgt cgtcatcatc ctgttgagcg ggctgcagat gatcccgaaa      660

gactactacg aggcggcgcg catcgacggc gcgaacggtt ggcagatctt ttggaacgtc      720

acgtttcctc agttgcgggg aagcatcgcc atcgcgggcc tgtttcgaat tcttcaggcg      780

ttcggtatct tcgacctgcc gttcgtgctc acgcagggtg gccctggttc gacgaccacg      840

tccctcgcca tgctgggtga ggaaacgctg ttcacgaacc ttcactttgg cttgggagca      900

gcggtcgccg tcagcacggt gatcctcatc ttaggggctt gtctaatatt cctgtccgcc      960

tttcgcggga tggtcgggga ggaagcgcaa tga                                   993


<210>   84
<211>   993
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   84
gtgtctacga tgctcgcaag cgaaggagaa gggaggcgag cgcgcatgtc aaaggcgatg       60

gaagggcatg catcgtttca aaccgatggc aggcgagcga gcgtcgttcg ccacgacgtt      120

cgcgcgggct ttgggatgtt gaccccagcc ggcattgtca tcctggccgt gaccattttc      180

cccatcctct attccgtgtg gatgagcttc aataacattc aattgacgga gaacggattt      240

cagttcacgt tcaacggcat tcaaaactac gtcgacgtct attccgcccc cctgttctgg      300

cacagtgtgt ggttcacggt gtattactcg attgtcacgg tcgcgatcga gttgtttttg      360

gggctgctca ttgcgcttgc catccagaac gtggagaaat tgaagagcgt ctcggtcgtg      420

gtgatgctca ttccttggtc gctcatcacg gtcatttccg ccgagatgtg gagttacatc      480

tacaacggcg tgtatggcgt cctgaacgcc atcctccaag gactgggttt catccacagc      540

cccatcaact ggaccggtga gccggtgacg gctgtgatcg ccctcatggc agcggatatt      600

tggaaaacta caccgtttgt cgtcatcatc ctgttgagcg ggctgcagat gatcccgaaa      660

gactactacg aggcggcgcg catcgacggc gcgaacggtt ggcagatctt ttggaacgtc      720

acgtttcctc agttgcgggg aagcatcgcc atcgcgggcc tgtttcgaat tcttcaggcg      780

ttcggtatct tcgacctgcc gttcgtgatt acgcagggtg gccctggttc gacgaccacg      840

tccctcgcca tgctgggtga ggaaacgctg ttcacgaacc ttcactttgg cttgggagca      900

gcggtcgccg tcagcacggt gatcctcatc ttaggggctt gtctaatatt cctgtccgcc      960

tttcgcggga tggtcgggga ggaagcgcaa tga                                   993


<210>   85
<211>   993
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   85
gtgtctacga tgctcgcaag cgaaggagaa gggaggcgag cgcgcatgtc aaaggcgatg       60

gaagggcatg catcgtttca aaccgatggc aggcgagcga gcgtcgttcg ccacgacgtt      120

cgcgcgggct ttgggatgtt gaccccagcc ggcattgtca tcctggccgt gaccattttc      180

cccatcctct attccgtgtg gatgagcttc aataacattc aattgacgga gaacggattt      240

cagttcacgt tcaacggcat tcaaaactac gtcgacgtct attccgcccc cctgttctgg      300

cacagtgtgt ggttcacggt gtattactcg attgtcacgg tcgcgatcga gttgtttttg      360

gggctgctca ttgcgcttgc catccagaac gtggagaaat tgaagagcgt ctcggtcgtg      420

gtgatgctca ttccttggtc gctcatcacg gtcatttccg ccgagatgtg gagttacatc      480

tacaacggcg tgtatggcgt cctgaacgcc atcctccaag gactgggttt catccacagc      540

cccatcaact ggaccggtga gccggtgacg gctgtgatcg ccctcatggc agcggatatt      600

tggaaaacta caccgtttgt cgtcatcatc ctgttgagcg ggctgcagat gatcccgaaa      660

gactactacg aggcggcgcg catcgaaggc gcgaacggtt ggcagatctt ttggaacgtc      720

acgtttcctc agttgcgggg aagcatcgcc atcgcgggcc tgtttcgaat tcttcaggcg      780

ttcggtatct tcgacctgcc gttcgtgctc acgcagggtg gccctggttc gacgaccacg      840

tccctcgcca tgctgggtga ggaaacgctg ttcacgaacc ttcactttgg cttgggagca      900

gcggtcgccg tcagcacggt gatcctcatc ttaggggctt gtctaatatt cctgtccgcc      960

tttcgcggga tggtcgggga ggaagcgcaa tga                                   993


<210>   86
<211>   293
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   86
Met Ser Asn Ile Pro Val Arg Leu Ser Arg Asp Gly Arg Gly Gly Ser 
                5                   10                  15      

Ala Met Arg Lys Pro Leu Tyr Gln Arg Ile Ile Gly Tyr Val Val Leu 
            20                  25                  30          

Ile Phe Phe Leu Val Val Ile Leu Leu Pro Phe Tyr Trp Met Phe Val 
        35                  40                  45              

Thr Ser Phe Glu Pro Asn Ser Asp Ile Ser Ala Tyr Pro Pro Ala Tyr 
    50                  55                  60                  

Phe Pro His His Trp Thr Leu Ser His Tyr Glu Glu Ala Phe Gly Gln 
65                  70                  75                  80  

Phe His Phe Gly Arg Tyr Ile Leu Asn Ser Val Ile Val Ser Ile Thr 
                85                  90                  95      

Ser Thr Phe Phe Val Leu Leu Phe Gly Ser Met Ala Gly Phe Ala Ile 
            100                 105                 110         

Ala Arg Leu Pro Ile Lys Ala Lys Gln Pro Met Leu Ile Leu Leu Leu 
        115                 120                 125             

Ile Ile Ser Val Phe Pro Pro Leu Val Val Ile Thr Pro Leu Tyr Met 
    130                 135                 140                 

Leu Leu Arg Asp Val Gly Trp Leu Asp Ser Tyr Gln Ala Leu Val Ile 
145                 150                 155                 160 

Pro Tyr Thr Ala Phe Asn Leu Pro Phe Ala Ile Trp Ile Leu Arg Asn 
                165                 170                 175     

Tyr Phe Leu Gln Val Pro Gly Ala Leu Phe Glu Ala Ala Lys Ile Asp 
            180                 185                 190         

Gly Ala Ser Val Phe Met Ser Tyr Trp Arg Ile Phe Leu Pro Leu Thr 
        195                 200                 205             

Thr Pro Gly Leu Phe Thr Ala Ala Val Phe Thr Phe Val Ala Cys Trp 
    210                 215                 220                 

Thr Glu Phe Phe Met Ala Leu Val Phe Asn Pro Asp Asn Thr Met Arg 
225                 230                 235                 240 

Thr Ile Pro Val Gly Ile Ala Leu Phe Ser Gly Gln Tyr Thr Val Pro 
                245                 250                 255     

Tyr Gly Thr Ile Phe Ala Gly Ser Val Val Ser Ile Val Pro Ile Val 
            260                 265                 270         

Ile Leu Val Val Ile Phe Arg Arg Trp Ile Val Ser Gly Leu Thr Gln 
        275                 280                 285             

Gly Ala Val Lys Gly 
    290             

<210>   87
<211>   882
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   87
ttgtctaata ttcctgtccg cctttcgcgg gatggtcggg gaggaagcgc aatgagaaag       60

ccgttgtatc aacgcatcat cggctatgtc gtgctcattt tctttctcgt cgtgatcctg      120

ctcccattct attggatgtt cgtcacgtcg ttcgagccca attccgacat cagcgcttat      180

ccgccggcgt acttcccgca tcattggacg ctttctcatt atgaagaggc cttcggccaa      240

tttcactttg gacggtacat cctcaacagc gtgattgtct ccatcacatc gacgttcttc      300

gtgcttctgt tcggatccat ggcggggttt gcgattgcac ggcttcccat caaggccaag      360

cagccgatgc tcatccttct gctcatcatc tcggtgtttc cgccgctcgt cgtgatcacg      420

cccctgtata tgttgcttcg cgacgtgggg tggctcgact cctatcaggc gctcgtcatt      480

ccgtatacgg cgttcaactt gccgtttgcc atttggattc tgcggaacta ttttttgcag      540

gtgccaggtg ccttgtttga agcggctaaa atcgacggtg cgtccgtgtt catgtcgtac      600

tggcgcatct tcctgccgct caccacgccg gggctcttta cggcagccgt gttcacgttc      660

gtcgcctgct ggacggagtt cttcatggcg ctcgtgttca accctgacaa caccatgcgc      720

accattccgg ttggcattgc gctgttcagc gggcagtaca cggttccgta cggcaccatc      780

tttgctggct ccgtggtgtc gattgtcccc atcgtcattc tcgtggtgat cttccgccgc      840

tggatcgtgt cggggttgac gcagggcgct gtcaaaggct aa                         882


<210>   88
<211>   252
<212>   PRT
<213>   Saccharopolyspora erythraea NRRL 2338

<400>   88
Pro Leu Tyr Trp Met Val Val Asn Ser Leu Lys Gly Gly Ala Glu Leu 
                5                   10                  15      

Gly Ala Thr Pro Pro Thr Pro Trp Pro Ser Asp Pro Thr Val Asp Asn 
            20                  25                  30          

Tyr Val Gln Ala Phe Ala Gly Asn Gly Phe Gly Gly Tyr Leu Val Asn 
        35                  40                  45              

Ser Leu Val Val Ser Val Val Ser Thr Val Val Val Val Ser Leu Ala 
    50                  55                  60                  

Thr Phe Ala Gly Tyr Ala Leu Ala Arg Leu Pro Met Arg Gly Arg Arg 
65                  70                  75                  80  

Pro Leu Met Ile Ala Leu Leu Met Ile Ser Val Phe Pro Ala Ile Ala 
                85                  90                  95      

Val Val Thr Pro Leu Tyr Leu Val Glu Arg Gln Leu Gly Leu Leu Asn 
            100                 105                 110         

Ser His Leu Gly Leu Ile Ile Pro Tyr Val Ala Phe Asn Leu Pro Leu 
        115                 120                 125             

Ala Ile Trp Ile Met Arg Asn Tyr Met Leu Gly Val Pro Thr Ala Leu 
    130                 135                 140                 

Glu Asp Ala Ala Thr Val Asp Gly Ala Ser Pro Thr Arg Thr Val Leu 
145                 150                 155                 160 

Gln Ile Val Val Pro Val Val Arg Pro Gly Ile Leu Thr Ala Ala Ile 
                165                 170                 175     

Phe Thr Phe Thr Ala Thr Trp Thr Glu Phe Leu Met Ala Leu Thr Phe 
            180                 185                 190         

Asn Ser Gln Asn Asp Tyr Arg Thr Ile Pro Val Gly Ile Ser Leu Phe 
        195                 200                 205             

Gly Ser Ser Phe Glu Val Pro His Gly Thr Ile Phe Ala Ala Ala Val 
    210                 215                 220                 

Ser Ala Thr Ala Pro Ile Ala Ile Leu Val Leu Val Phe Arg Arg Ser 
225                 230                 235                 240 

Val Val Ser Gly Leu Ala Ser Gly Ala Val Lys Gly 
                245                 250         

<210>   89
<211>   274
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   89
Lys Asn Thr Ile Asn Gln Ile Ile Phe Tyr Ile Phe Leu Thr Ile Phe 
                5                   10                  15      

Leu Val Tyr Ile Ile Phe Pro Phe Leu Trp Gln Thr Leu Thr Ser Phe 
            20                  25                  30          

Lys Thr Pro Gln Glu Leu Phe Ser Ile Pro Pro Thr Trp Ile Pro Ser 
        35                  40                  45              

Lys Ile Tyr Thr Gly Tyr Tyr Ile Asn Val Phe Thr Lys Arg Pro Phe 
    50                  55                  60                  

Leu Thr Tyr Leu Lys Asn Ser Phe Ile Val Ala Ser Ser Thr Thr Leu 
65                  70                  75                  80  

Phe Ser Leu Phe Val Ser Ser Phe Ala Ala Tyr Ala Leu Ala Arg Leu 
                85                  90                  95      

Lys Phe Lys Gly Lys Ala Ile Ile Leu Ser Leu Val Leu Ser Val Ser 
            100                 105                 110         

Met Phe Pro Gly Ile Ala Ile Val Ser Pro Leu Phe Ile Phe Leu Lys 
        115                 120                 125             

Asn Val Asn Leu Leu Asn Ser Tyr Leu Gly Leu Ile Leu Thr Tyr Thr 
    130                 135                 140                 

Thr Phe Ala Ile Pro Leu Ser Leu Trp Ile Leu Thr Ser Phe Phe Lys 
145                 150                 155                 160 

Glu Ile Pro Phe Glu Leu Glu Glu Ser Ala Lys Val Asp Gly Ala Thr 
                165                 170                 175     

Pro Met Gln Ala Phe Leu Lys Ile Ile Met Pro Leu Ala Thr Pro Gly 
            180                 185                 190         

Met Phe Thr Thr Ala Ile Leu Thr Phe Ile Ala Ala Trp Asn Glu Phe 
        195                 200                 205             

Leu Phe Ala Leu Val Phe Asn Thr Gln Asp Ser Met Arg Thr Val Pro 
    210                 215                 220                 

Val Gly Ile Ala Met Phe Pro Gly Glu His Asp Leu Pro Trp Gly Asp 
225                 230                 235                 240 

Ile Ala Ala Ala Ser Val Val Val Thr Val Pro Leu Ile Ile Met Val 
                245                 250                 255     

Leu Ile Phe Gln Lys Arg Ile Ile Ser Gly Leu Thr Ala Gly Ala Val 
            260                 265                 270         

Lys Gly 
        

<210>   90
<211>   252
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   90
Pro Phe Leu Trp Val Leu Leu Ser Ser Ile Lys Pro Leu Ser Glu Leu 
                5                   10                  15      

Phe Gly Asp Lys Ala Phe Asp Trp Phe Thr Ser His Pro Thr Leu Lys 
            20                  25                  30          

Ser Tyr Val Ser Val Phe Val Asn Tyr Pro Phe Leu Arg Tyr Leu Trp 
        35                  40                  45              

Asn Ser Thr Val Val Ala Thr Ile Thr Thr Val Tyr Thr Val Phe Val 
    50                  55                  60                  

Ala Ala Phe Ala Ala Tyr Ala Ile Ala Arg Leu Glu Phe Lys Gly Lys 
65                  70                  75                  80  

Thr Val Ile Leu Gly Leu Val Leu Ala Val Ser Met Phe Pro Gln Ile 
                85                  90                  95      

Ala Thr Ile Ser Pro Ile Tyr Met Phe Val Lys Lys Phe Gly Leu Thr 
            100                 105                 110         

Asn Ser Tyr Leu Gly Leu Ile Ile Pro Tyr Thr Thr Phe Ala Leu Pro 
        115                 120                 125             

Leu Ser Ile Trp Leu Leu Val Thr Phe Phe Arg Lys Ile Pro Phe Asp 
    130                 135                 140                 

Leu Glu Glu Ala Ala Lys Met Asp Gly Ala Thr Pro Met Gln Thr Tyr 
145                 150                 155                 160 

Phe Lys Ile Ile Leu Pro Leu Ala Val Pro Gly Val Phe Thr Thr Ser 
                165                 170                 175     

Ile Leu Val Phe Ile Ala Ala Trp Asn Glu Phe Leu Phe Ala Leu Thr 
            180                 185                 190         

Ile Asn Thr Ala Glu Lys Tyr Lys Thr Val Pro Val Gly Ile Ala Met 
        195                 200                 205             

Phe Gln Gly Gln Tyr Thr Ile Pro Trp Gly Glu Ile Ser Ala Ala Thr 
    210                 215                 220                 

Val Ile Val Thr Ile Pro Leu Val Ile Met Val Leu Leu Phe Gln Arg 
225                 230                 235                 240 

Arg Ile Val Ser Gly Leu Thr Ser Gly Ser Val Lys 
                245                 250         

<210>   91
<211>   252
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   91
Pro Phe Leu Trp Val Leu Leu Ser Ser Ile Lys Pro Leu Ser Glu Leu 
                5                   10                  15      

Phe Gly Asp Lys Ala Phe Gln Trp Phe Thr Ser His Pro Thr Leu Lys 
            20                  25                  30          

Ser Tyr Ile Ser Val Phe Val Asn Tyr Pro Phe Leu Arg Tyr Leu Trp 
        35                  40                  45              

Asn Ser Thr Val Val Ala Thr Ile Thr Thr Val Tyr Thr Val Phe Val 
    50                  55                  60                  

Ala Ala Phe Ala Ala Tyr Ala Ile Ala Arg Leu Glu Phe Arg Gly Lys 
65                  70                  75                  80  

Thr Val Ile Leu Gly Leu Val Leu Ala Val Ser Met Phe Pro Gln Ile 
                85                  90                  95      

Ala Thr Ile Ser Pro Ile Tyr Met Phe Val Lys Lys Phe Gly Leu Thr 
            100                 105                 110         

Asn Ser Tyr Leu Gly Leu Ile Ile Pro Tyr Thr Thr Phe Ala Leu Pro 
        115                 120                 125             

Leu Ser Ile Trp Leu Leu Val Thr Phe Phe Arg Lys Ile Pro Phe Asp 
    130                 135                 140                 

Leu Glu Glu Ala Ala Lys Ile Asp Gly Ala Thr Pro Met Gln Thr Tyr 
145                 150                 155                 160 

Phe Lys Val Ile Leu Pro Leu Ala Val Pro Gly Val Phe Thr Thr Ser 
                165                 170                 175     

Ile Leu Val Phe Ile Ala Ala Trp Asn Glu Phe Leu Phe Ala Leu Thr 
            180                 185                 190         

Ile Asn Thr Ala Glu Lys Tyr Lys Thr Val Pro Val Gly Ile Ala Met 
        195                 200                 205             

Phe Gln Gly Gln Tyr Thr Ile Pro Trp Gly Glu Ile Ser Ala Ala Thr 
    210                 215                 220                 

Val Ile Val Thr Ile Pro Leu Val Ile Met Val Leu Leu Phe Gln Arg 
225                 230                 235                 240 

Arg Ile Val Ser Gly Leu Thr Ser Gly Ser Val Lys 
                245                 250         

<210>   92
<211>   250
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   92
Pro Phe Ile Trp Val Phe Leu Thr Ser Ile Lys Pro Val Asn Glu Ile 
                5                   10                  15      

Phe Ser Ser Phe Lys Trp Phe Thr Ser Asn Pro Thr Leu Ser Ser Tyr 
            20                  25                  30          

Glu Ala Ala Leu Thr Asn Arg Pro Leu Leu Arg Tyr Met Leu Asn Ser 
        35                  40                  45              

Phe Val Val Ser Leu Leu Thr Thr Val Leu Ser Leu Thr Phe Ala Ala 
    50                  55                  60                  

Phe Thr Ala Tyr Ala Val Thr Arg Leu Pro Ile Lys Gly Lys Gly Leu 
65                  70                  75                  80  

Ile Leu Gly Leu Val Leu Ala Ala Ser Met Phe Pro Gln Ile Ala Ile 
                85                  90                  95      

Ile Ser Pro Met Phe Asn Leu Val Thr Asn Leu Gly Leu Arg Asn Ser 
            100                 105                 110         

Tyr Leu Gly Leu Ile Ile Pro Tyr Ile Thr Ile Ser Leu Pro Leu Ala 
        115                 120                 125             

Ile Trp Ile Leu Ser Thr Phe Phe Lys Lys Ile Pro Tyr Glu Leu Glu 
    130                 135                 140                 

Glu Ser Ala Lys Leu Asp Gly Ala Ser Pro Phe Gln Thr Phe Arg Lys 
145                 150                 155                 160 

Ile Ile Leu Pro Leu Ala Thr Pro Gly Ile Phe Thr Thr Gly Ile Leu 
                165                 170                 175     

Val Phe Ile Ala Ala Trp Asn Glu Tyr Leu Phe Ala Leu Thr Ile Asn 
            180                 185                 190         

Ser Asp Asp Gln Trp Arg Thr Val Pro Val Gly Ile Ser Met Tyr Gln 
        195                 200                 205             

Ser Glu Phe Ser Ile Pro Trp Gly Asp Ile Ser Ala Ala Thr Val Ile 
    210                 215                 220                 

Val Thr Ile Pro Ile Val Val Leu Val Leu Ile Phe Gln Arg Arg Ile 
225                 230                 235                 240 

Val Ser Gly Leu Thr Ser Gly Ser Val Lys 
                245                 250 

<210>   93
<211>   293
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   93
Met Ser Asn Ile Pro Val Arg Leu Ser Arg Asp Gly Arg Gly Gly Ser 
                5                   10                  15      

Ala Met Arg Lys Pro Leu Tyr Gln Arg Ile Ile Gly Tyr Val Val Leu 
            20                  25                  30          

Ile Phe Phe Leu Val Val Ile Leu Leu Pro Phe Tyr Trp Met Phe Val 
        35                  40                  45              

Thr Ser Phe Glu Pro Asn Ser Asp Ile Ser Ala Tyr Pro Pro Ala Tyr 
    50                  55                  60                  

Phe Pro His His Trp Thr Leu Ser His Tyr Glu Glu Ala Phe Gly Gln 
65                  70                  75                  80  

Phe His Phe Gly Arg Tyr Ile Leu Asn Ser Val Ile Val Ser Ile Thr 
                85                  90                  95      

Ser Thr Phe Phe Val Leu Leu Phe Gly Ser Met Ala Gly Phe Ala Leu 
            100                 105                 110         

Ala Arg Leu Pro Ile Lys Ala Lys Gln Pro Met Leu Ile Leu Leu Leu 
        115                 120                 125             

Ile Ile Ser Val Phe Pro Pro Leu Val Val Ile Thr Pro Leu Tyr Met 
    130                 135                 140                 

Leu Leu Arg Asp Val Gly Trp Leu Asp Ser Tyr Gln Ala Leu Val Ile 
145                 150                 155                 160 

Pro Tyr Thr Ala Phe Asn Leu Pro Phe Ala Ile Trp Ile Leu Arg Asn 
                165                 170                 175     

Tyr Phe Leu Gln Val Pro Gly Ala Leu Phe Glu Ala Ala Lys Ile Asp 
            180                 185                 190         

Gly Ala Ser Val Phe Met Ser Tyr Trp Arg Ile Phe Leu Pro Leu Thr 
        195                 200                 205             

Thr Pro Gly Leu Phe Thr Ala Ala Val Phe Thr Phe Val Ala Cys Trp 
    210                 215                 220                 

Thr Glu Phe Phe Met Ala Leu Val Phe Asn Pro Asp Asn Thr Met Arg 
225                 230                 235                 240 

Thr Ile Pro Val Gly Ile Ala Leu Phe Ser Gly Gln Tyr Thr Val Pro 
                245                 250                 255     

Tyr Gly Thr Ile Phe Ala Gly Ser Val Val Ser Ile Val Pro Ile Val 
            260                 265                 270         

Ile Leu Val Val Ile Phe Arg Arg Trp Ile Val Ser Gly Leu Thr Gln 
        275                 280                 285             

Gly Ala Val Lys Gly 
    290             

<210>   94
<211>   293
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   94
Met Ser Asn Ile Pro Val Arg Leu Ser Arg Asp Gly Arg Gly Gly Ser 
                5                   10                  15      

Ala Met Arg Lys Pro Leu Tyr Gln Arg Ile Ile Gly Tyr Val Val Leu 
            20                  25                  30          

Ile Phe Phe Leu Val Val Ile Leu Leu Pro Phe Tyr Trp Met Phe Val 
        35                  40                  45              

Thr Ser Phe Glu Pro Asn Ser Asp Ile Ser Ala Tyr Pro Pro Ala Tyr 
    50                  55                  60                  

Phe Pro His His Trp Thr Leu Ser His Tyr Glu Glu Ala Phe Gly Gln 
65                  70                  75                  80  

Phe His Phe Gly Arg Tyr Ile Leu Asn Ser Val Ile Val Ser Ile Thr 
                85                  90                  95      

Ser Thr Phe Phe Val Leu Leu Phe Gly Ser Met Ala Gly Phe Ala Ile 
            100                 105                 110         

Ala Arg Leu Pro Ile Lys Ala Lys Gln Pro Met Leu Ile Leu Leu Leu 
        115                 120                 125             

Ile Ile Ser Ile Phe Pro Pro Leu Val Val Ile Thr Pro Leu Tyr Met 
    130                 135                 140                 

Leu Leu Arg Asp Val Gly Trp Leu Asp Ser Tyr Gln Ala Leu Val Ile 
145                 150                 155                 160 

Pro Tyr Thr Ala Phe Asn Leu Pro Phe Ala Ile Trp Ile Leu Arg Asn 
                165                 170                 175     

Tyr Phe Leu Gln Val Pro Gly Ala Leu Phe Glu Ala Ala Lys Ile Asp 
            180                 185                 190         

Gly Ala Ser Val Phe Met Ser Tyr Trp Arg Ile Phe Leu Pro Leu Thr 
        195                 200                 205             

Thr Pro Gly Leu Phe Thr Ala Ala Val Phe Thr Phe Val Ala Cys Trp 
    210                 215                 220                 

Thr Glu Phe Phe Met Ala Leu Val Phe Asn Pro Asp Asn Thr Met Arg 
225                 230                 235                 240 

Thr Ile Pro Val Gly Ile Ala Leu Phe Ser Gly Gln Tyr Thr Val Pro 
                245                 250                 255     

Tyr Gly Thr Ile Phe Ala Gly Ser Val Val Ser Ile Val Pro Ile Val 
            260                 265                 270         

Ile Leu Val Val Ile Phe Arg Arg Trp Ile Val Ser Gly Leu Thr Gln 
        275                 280                 285             

Gly Ala Val Lys Gly 
    290             

<210>   95
<211>   293
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   95
Met Ser Asn Ile Pro Val Arg Leu Ser Arg Asp Gly Arg Gly Gly Ser 
                5                   10                  15      

Ala Met Arg Lys Pro Leu Tyr Gln Arg Ile Ile Gly Tyr Val Val Leu 
            20                  25                  30          

Ile Phe Phe Leu Val Val Ile Leu Leu Pro Phe Tyr Trp Met Phe Val 
        35                  40                  45              

Thr Ser Phe Glu Pro Asn Ser Asp Ile Ser Ala Tyr Pro Pro Ala Tyr 
    50                  55                  60                  

Phe Pro His His Trp Thr Leu Ser His Tyr Glu Glu Ala Phe Gly Gln 
65                  70                  75                  80  

Phe His Phe Gly Arg Tyr Ile Leu Asn Ser Val Ile Val Ser Ile Thr 
                85                  90                  95      

Ser Thr Phe Phe Val Leu Leu Phe Gly Ser Met Ala Gly Phe Ala Ile 
            100                 105                 110         

Ala Arg Leu Pro Ile Lys Ala Lys Gln Pro Met Leu Ile Leu Leu Leu 
        115                 120                 125             

Ile Ile Ser Val Phe Pro Pro Leu Val Val Ile Thr Pro Leu Tyr Met 
    130                 135                 140                 

Leu Leu Arg Asp Val Gly Trp Leu Asp Ser Tyr Gln Ala Leu Val Ile 
145                 150                 155                 160 

Pro Tyr Thr Ala Phe Asn Leu Pro Phe Ala Ile Trp Ile Leu Arg Asn 
                165                 170                 175     

Tyr Phe Leu Gln Val Pro Gly Ala Leu Phe Glu Ala Ala Arg Ile Asp 
            180                 185                 190         

Gly Ala Ser Val Phe Met Ser Tyr Trp Arg Ile Phe Leu Pro Leu Thr 
        195                 200                 205             

Thr Pro Gly Leu Phe Thr Ala Ala Val Phe Thr Phe Val Ala Cys Trp 
    210                 215                 220                 

Thr Glu Phe Phe Met Ala Leu Val Phe Asn Pro Asp Asn Thr Met Arg 
225                 230                 235                 240 

Thr Ile Pro Val Gly Ile Ala Leu Phe Ser Gly Gln Tyr Thr Val Pro 
                245                 250                 255     

Tyr Gly Thr Ile Phe Ala Gly Ser Val Val Ser Ile Val Pro Ile Val 
            260                 265                 270         

Ile Leu Val Val Ile Phe Arg Arg Trp Ile Val Ser Gly Leu Thr Gln 
        275                 280                 285             

Gly Ala Val Lys Gly 
    290             

<210>   96
<211>   293
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   96
Met Ser Asn Ile Pro Val Arg Leu Ser Arg Asp Gly Arg Gly Gly Ser 
                5                   10                  15      

Ala Met Arg Lys Pro Leu Tyr Gln Arg Ile Ile Gly Tyr Val Val Leu 
            20                  25                  30          

Ile Phe Phe Leu Val Val Ile Leu Leu Pro Phe Tyr Trp Met Phe Val 
        35                  40                  45              

Thr Ser Phe Glu Pro Asn Ser Asp Ile Ser Ala Tyr Pro Pro Ala Tyr 
    50                  55                  60                  

Phe Pro His His Trp Thr Leu Ser His Tyr Glu Glu Ala Phe Gly Gln 
65                  70                  75                  80  

Phe His Phe Gly Arg Tyr Ile Leu Asn Ser Val Ile Val Ser Ile Thr 
                85                  90                  95      

Ser Thr Phe Phe Val Leu Leu Phe Gly Ser Met Ala Gly Phe Ala Ile 
            100                 105                 110         

Ala Arg Leu Pro Ile Lys Ala Lys Gln Pro Met Leu Ile Leu Leu Leu 
        115                 120                 125             

Ile Ile Ser Val Phe Pro Pro Leu Val Val Ile Thr Pro Leu Tyr Met 
    130                 135                 140                 

Leu Leu Arg Asp Val Gly Trp Leu Asp Ser Tyr Gln Ala Leu Val Ile 
145                 150                 155                 160 

Pro Tyr Thr Ala Phe Asn Leu Pro Phe Ala Ile Trp Ile Leu Arg Asn 
                165                 170                 175     

Tyr Phe Leu Gln Val Pro Gly Ala Leu Phe Glu Ala Ala Lys Ile Asp 
            180                 185                 190         

Gly Ala Ser Val Phe Met Ser Tyr Trp Arg Ile Phe Ile Pro Leu Thr 
        195                 200                 205             

Thr Pro Gly Leu Phe Thr Ala Ala Val Phe Thr Phe Val Ala Cys Trp 
    210                 215                 220                 

Thr Glu Phe Phe Met Ala Leu Val Phe Asn Pro Asp Asn Thr Met Arg 
225                 230                 235                 240 

Thr Ile Pro Val Gly Ile Ala Leu Phe Ser Gly Gln Tyr Thr Val Pro 
                245                 250                 255     

Tyr Gly Thr Ile Phe Ala Gly Ser Val Val Ser Ile Val Pro Ile Val 
            260                 265                 270         

Ile Leu Val Val Ile Phe Arg Arg Trp Ile Val Ser Gly Leu Thr Gln 
        275                 280                 285             

Gly Ala Val Lys Gly 
    290             

<210>   97
<211>   293
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   97
Met Ser Asn Ile Pro Val Arg Leu Ser Arg Asp Gly Arg Gly Gly Ser 
                5                   10                  15      

Ala Met Arg Lys Pro Leu Tyr Gln Arg Ile Ile Gly Tyr Val Val Leu 
            20                  25                  30          

Ile Phe Phe Leu Val Val Ile Leu Leu Pro Phe Tyr Trp Met Phe Val 
        35                  40                  45              

Thr Ser Phe Glu Pro Asn Ser Asp Ile Ser Ala Tyr Pro Pro Ala Tyr 
    50                  55                  60                  

Phe Pro His His Trp Thr Leu Ser His Tyr Glu Glu Ala Phe Gly Gln 
65                  70                  75                  80  

Phe His Phe Gly Arg Tyr Ile Leu Asn Ser Val Ile Val Ser Ile Thr 
                85                  90                  95      

Ser Thr Phe Phe Val Leu Leu Phe Gly Ser Met Ala Gly Phe Ala Ile 
            100                 105                 110         

Ala Arg Leu Pro Ile Lys Ala Lys Gln Pro Met Ile Ile Leu Leu Leu 
        115                 120                 125             

Ile Ile Ser Val Phe Pro Pro Leu Val Val Ile Thr Pro Leu Tyr Met 
    130                 135                 140                 

Leu Leu Arg Asp Val Gly Trp Leu Asp Ser Tyr Gln Ala Leu Val Ile 
145                 150                 155                 160 

Pro Tyr Thr Ala Phe Asn Leu Pro Phe Ala Ile Trp Ile Leu Arg Asn 
                165                 170                 175     

Tyr Phe Leu Gln Val Pro Gly Ala Leu Phe Glu Ala Ala Lys Ile Asp 
            180                 185                 190         

Gly Ala Ser Val Phe Met Ser Tyr Trp Arg Ile Phe Leu Pro Leu Thr 
        195                 200                 205             

Thr Pro Gly Leu Phe Thr Ala Ala Val Phe Thr Phe Val Ala Cys Trp 
    210                 215                 220                 

Thr Glu Phe Phe Met Ala Leu Val Phe Asn Pro Asp Asn Thr Met Arg 
225                 230                 235                 240 

Thr Ile Pro Val Gly Ile Ala Leu Phe Ser Gly Gln Tyr Thr Val Pro 
                245                 250                 255     

Tyr Gly Thr Ile Phe Ala Gly Ser Val Val Ser Ile Val Pro Ile Val 
            260                 265                 270         

Ile Leu Val Val Ile Phe Arg Arg Trp Ile Val Ser Gly Leu Thr Gln 
        275                 280                 285             

Gly Ala Val Lys Gly 
    290             

<210>   98
<211>   882
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   98
ttgtctaata ttcctgtccg cctttcgcgg gatggtcggg gaggaagcgc aatgagaaag       60

ccgttgtatc aacgcatcat cggctatgtc gtgctcattt tctttctcgt cgtgatcctg      120

ctcccattct attggatgtt cgtcacgtcg ttcgagccca attccgacat cagcgcttat      180

ccgccggcgt acttcccgca tcattggacg ctttctcatt atgaagaggc cttcggccaa      240

tttcactttg gacggtacat cctcaacagc gtgattgtct ccatcacatc gacgttcttc      300

gtgcttctgt tcggatccat ggcggggttt gcgttagcac ggcttcccat caaggccaag      360

cagccgatgc tcatccttct gctcatcatc tcggtgtttc cgccgctcgt cgtgatcacg      420

cccctgtata tgttgcttcg cgacgtgggg tggctcgact cctatcaggc gctcgtcatt      480

ccgtatacgg cgttcaactt gccgtttgcc atttggattc tgcggaacta ttttttgcag      540

gtgccaggtg ccttgtttga agcggctaaa atcgacggtg cgtccgtgtt catgtcgtac      600

tggcgcatct tcctgccgct caccacgccg gggctcttta cggcagccgt gttcacgttc      660

gtcgcctgct ggacggagtt cttcatggcg ctcgtgttca accctgacaa caccatgcgc      720

accattccgg ttggcattgc gctgttcagc gggcagtaca cggttccgta cggcaccatc      780

tttgctggct ccgtggtgtc gattgtcccc atcgtcattc tcgtggtgat cttccgccgc      840

tggatcgtgt cggggttgac gcagggcgct gtcaaaggct aa                         882


<210>   99
<211>   882
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   99
ttgtctaata ttcctgtccg cctttcgcgg gatggtcggg gaggaagcgc aatgagaaag       60

ccgttgtatc aacgcatcat cggctatgtc gtgctcattt tctttctcgt cgtgatcctg      120

ctcccattct attggatgtt cgtcacgtcg ttcgagccca attccgacat cagcgcttat      180

ccgccggcgt acttcccgca tcattggacg ctttctcatt atgaagaggc cttcggccaa      240

tttcactttg gacggtacat cctcaacagc gtgattgtct ccatcacatc gacgttcttc      300

gtgcttctgt tcggatccat ggcggggttt gcgattgcac ggcttcccat caaggccaag      360

cagccgatgc tcatccttct gctcatcatc tcgatttttc cgccgctcgt cgtgatcacg      420

cccctgtata tgttgcttcg cgacgtgggg tggctcgact cctatcaggc gctcgtcatt      480

ccgtatacgg cgttcaactt gccgtttgcc atttggattc tgcggaacta ttttttgcag      540

gtgccaggtg ccttgtttga agcggctaaa atcgacggtg cgtccgtgtt catgtcgtac      600

tggcgcatct tcctgccgct caccacgccg gggctcttta cggcagccgt gttcacgttc      660

gtcgcctgct ggacggagtt cttcatggcg ctcgtgttca accctgacaa caccatgcgc      720

accattccgg ttggcattgc gctgttcagc gggcagtaca cggttccgta cggcaccatc      780

tttgctggct ccgtggtgtc gattgtcccc atcgtcattc tcgtggtgat cttccgccgc      840

tggatcgtgt cggggttgac gcagggcgct gtcaaaggct aa                         882


<210>   100
<211>   882
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   100
ttgtctaata ttcctgtccg cctttcgcgg gatggtcggg gaggaagcgc aatgagaaag       60

ccgttgtatc aacgcatcat cggctatgtc gtgctcattt tctttctcgt cgtgatcctg      120

ctcccattct attggatgtt cgtcacgtcg ttcgagccca attccgacat cagcgcttat      180

ccgccggcgt acttcccgca tcattggacg ctttctcatt atgaagaggc cttcggccaa      240

tttcactttg gacggtacat cctcaacagc gtgattgtct ccatcacatc gacgttcttc      300

gtgcttctgt tcggatccat ggcggggttt gcgattgcac ggcttcccat caaggccaag      360

cagccgatgc tcatccttct gctcatcatc tcggtgtttc cgccgctcgt cgtgatcacg      420

cccctgtata tgttgcttcg cgacgtgggg tggctcgact cctatcaggc gctcgtcatt      480

ccgtatacgg cgttcaactt gccgtttgcc atttggattc tgcggaacta ttttttgcag      540

gtgccaggtg ccttgtttga agcggctcgt atcgacggtg cgtccgtgtt catgtcgtac      600

tggcgcatct tcctgccgct caccacgccg gggctcttta cggcagccgt gttcacgttc      660

gtcgcctgct ggacggagtt cttcatggcg ctcgtgttca accctgacaa caccatgcgc      720

accattccgg ttggcattgc gctgttcagc gggcagtaca cggttccgta cggcaccatc      780

tttgctggct ccgtggtgtc gattgtcccc atcgtcattc tcgtggtgat cttccgccgc      840

tggatcgtgt cggggttgac gcagggcgct gtcaaaggct aa                         882


<210>   101
<211>   882
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   101
ttgtctaata ttcctgtccg cctttcgcgg gatggtcggg gaggaagcgc aatgagaaag       60

ccgttgtatc aacgcatcat cggctatgtc gtgctcattt tctttctcgt cgtgatcctg      120

ctcccattct attggatgtt cgtcacgtcg ttcgagccca attccgacat cagcgcttat      180

ccgccggcgt acttcccgca tcattggacg ctttctcatt atgaagaggc cttcggccaa      240

tttcactttg gacggtacat cctcaacagc gtgattgtct ccatcacatc gacgttcttc      300

gtgcttctgt tcggatccat ggcggggttt gcgattgcac ggcttcccat caaggccaag      360

cagccgatgc tcatccttct gctcatcatc tcggtgtttc cgccgctcgt cgtgatcacg      420

cccctgtata tgttgcttcg cgacgtgggg tggctcgact cctatcaggc gctcgtcatt      480

ccgtatacgg cgttcaactt gccgtttgcc atttggattc tgcggaacta ttttttgcag      540

gtgccaggtg ccttgtttga agcggctaaa atcgacggtg cgtccgtgtt catgtcgtac      600

tggcgcatct tcattccgct caccacgccg gggctcttta cggcagccgt gttcacgttc      660

gtcgcctgct ggacggagtt cttcatggcg ctcgtgttca accctgacaa caccatgcgc      720

accattccgg ttggcattgc gctgttcagc gggcagtaca cggttccgta cggcaccatc      780

tttgctggct ccgtggtgtc gattgtcccc atcgtcattc tcgtggtgat cttccgccgc      840

tggatcgtgt cggggttgac gcagggcgct gtcaaaggct aa                         882


<210>   102
<211>   882
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   102
ttgtctaata ttcctgtccg cctttcgcgg gatggtcggg gaggaagcgc aatgagaaag       60

ccgttgtatc aacgcatcat cggctatgtc gtgctcattt tctttctcgt cgtgatcctg      120

ctcccattct attggatgtt cgtcacgtcg ttcgagccca attccgacat cagcgcttat      180

ccgccggcgt acttcccgca tcattggacg ctttctcatt atgaagaggc cttcggccaa      240

tttcactttg gacggtacat cctcaacagc gtgattgtct ccatcacatc gacgttcttc      300

gtgcttctgt tcggatccat ggcggggttt gcgattgcac ggcttcccat caaggccaag      360

cagccgatga ttatccttct gctcatcatc tcggtgtttc cgccgctcgt cgtgatcacg      420

cccctgtata tgttgcttcg cgacgtgggg tggctcgact cctatcaggc gctcgtcatt      480

ccgtatacgg cgttcaactt gccgtttgcc atttggattc tgcggaacta ttttttgcag      540

gtgccaggtg ccttgtttga agcggctaaa atcgacggtg cgtccgtgtt catgtcgtac      600

tggcgcatct tcctgccgct caccacgccg gggctcttta cggcagccgt gttcacgttc      660

gtcgcctgct ggacggagtt cttcatggcg ctcgtgttca accctgacaa caccatgcgc      720

accattccgg ttggcattgc gctgttcagc gggcagtaca cggttccgta cggcaccatc      780

tttgctggct ccgtggtgtc gattgtcccc atcgtcattc tcgtggtgat cttccgccgc      840

tggatcgtgt cggggttgac gcagggcgct gtcaaaggct aa                         882


<210>   103
<211>   540
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   103
Met His Arg Val His Ala Leu Phe His Ala Asn Ala Val Asp Tyr Ile 
                5                   10                  15      

Ile Ile Leu Val Tyr Phe Ala Phe Val Leu Gly Val Gly Phe Val Leu 
            20                  25                  30          

Arg Asn Arg Val Arg Thr Gly Glu Asp Phe Phe Leu Ser Gly Arg Ser 
        35                  40                  45              

Ile Pro Ala Trp Ile Thr Gly Leu Ala Phe Leu Ser Ala Asn Leu Gly 
    50                  55                  60                  

Ala Leu Glu Ile Leu Gly Met Thr Ala Ser Gly Ala Glu Tyr Gly Met 
65                  70                  75                  80  

Leu Thr Thr His Phe Tyr Trp Ile Gly Ala Ile Pro Ala Met Leu Phe 
                85                  90                  95      

Leu Gly Leu Tyr Met Met Pro Phe Tyr Tyr Val Ser Lys Val Arg Ser 
            100                 105                 110         

Val Pro Glu Phe Leu Lys Leu Arg Tyr Asn Glu Ala Thr Arg Ala Leu 
        115                 120                 125             

Asn Ala Ile Ala Phe Ala Val Met Thr Val Leu Thr Ser Gly Ile Ser 
    130                 135                 140                 

Leu Tyr Ser Met Ala Leu Ile Phe Gln Ile Leu Ile Gly Trp Ser Phe 
145                 150                 155                 160 

Asp Thr Ser Ile Leu Val Ser Ala Leu Val Val Leu Ile Tyr Val Ala 
                165                 170                 175     

Leu Gly Gly Leu Thr Ser Ser Ile Phe Asn Glu Val Val Gln Phe Phe 
            180                 185                 190         

Leu Ile Trp Ala Gly Leu Leu Pro Ile Pro Leu Ile Gly Leu His Asn 
        195                 200                 205             

Leu Gly Gly Trp Gln Gly Met Met Ser Arg Leu Pro Ala Gly Phe Gly 
    210                 215                 220                 

His Leu Trp Ala Asn Leu Gly Ser Pro Ser His Asn Pro Met Gly Ile 
225                 230                 235                 240 

Gly Trp Leu Gly Val Val Leu Gly Leu Gly Phe Val Leu Ser Phe Gly 
                245                 250                 255     

Tyr Trp Thr Thr Asp Phe Leu Val Val Gln Arg Thr Leu Ala Ala Lys 
            260                 265                 270         

Asp Leu Arg Ala Ala Gln Leu Thr Pro Ile Tyr Ala Ala Phe Phe Lys 
        275                 280                 285             

Met Ile Val Pro Ile Leu Val Ile Ile Pro Gly Leu Ile Ala Leu Ala 
    290                 295                 300                 

Ile Phe Pro Lys Ile Gly His Ser Pro Asn Met Ser Tyr Asn Leu Ala 
305                 310                 315                 320 

Leu Pro Leu Leu Ile Ala Lys Tyr Tyr Pro Pro Gly Met Leu Gly Leu 
                325                 330                 335     

Gly Leu Thr Ala Met Leu Ala Ser Phe Met Ser Gly Met Ala Gly Asn 
            340                 345                 350         

Val Thr Ala Phe Thr Thr Val Trp Thr Tyr Asp Ile Tyr Gln Ala Tyr 
        355                 360                 365             

Ile Lys Lys Asp Ala Pro Asp Lys His Tyr Val Asn Met Gly Arg Trp 
    370                 375                 380                 

Ala Val Val Val Gly Val Ile Ile Ser Ile Gly Thr Ala Tyr Phe Ala 
385                 390                 395                 400 

Ala Gly Phe Pro Ser Val Met Asp Tyr Met Gln Thr Leu Phe Ser Phe 
                405                 410                 415     

Phe Asn Ala Pro Leu Phe Ala Thr Phe Leu Leu Gly Met Phe Trp Lys 
            420                 425                 430         

Lys Ala Thr Pro Trp Gly Gly Phe Trp Gly Leu Leu Ala Gly Ile Ala 
        435                 440                 445             

Gly Ala Phe Ala Met Tyr Phe Phe Leu Pro Ala His Met Phe Ser Ser 
    450                 455                 460                 

Pro Asp Ala Gly Asn Phe Trp Arg Ala Trp Trp Ala Trp Val Ile Thr 
465                 470                 475                 480 

Val Val Val Thr Val Leu Val Ser Leu Val Thr Gln Gly Lys Arg Pro 
                485                 490                 495     

Glu Glu Leu Glu Gly Leu Val Tyr Gly Leu Ser Lys Arg Pro Asp Tyr 
            500                 505                 510         

Ser Gly Tyr Pro Trp Tyr Lys Arg Pro Gly Tyr Leu Ala Ala Ile Val 
        515                 520                 525             

Phe Val Ile Leu Val Gly Leu Asn Ile Ala Phe Trp 
    530                 535                 540 

<210>   104
<211>   1623
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   104
gtgcatcggg tgcacgcgct atttcatgcg aacgccgtgg actacatcat catcctggtc       60

tacttcgctt tcgtcctcgg cgtcggattc gtccttcgta accgcgttcg cactggagag      120

gatttctttt tgtccggccg atccatcccg gcctggatca cgggcttggc gtttctatcc      180

gccaacctcg gggcgctcga gattctcggc atgaccgcga gcggcgccga atacggcatg      240

ctcacgactc acttttactg gatcggtgcg atcccggcca tgttgtttct cggcctgtac      300

atgatgccgt tttactatgt gtcgaaggtg cgctcggtgc cggagttctt gaaactgcgg      360

tacaacgaag cgacccgcgc gctcaatgcc atcgcgttcg ccgtgatgac cgtcctgacg      420

tcgggcatca gcttgtattc catggcgctg atctttcaga tcttgattgg ttggtcgttt      480

gacaccagca ttctcgtgtc tgcgctcgtg gttttgatct acgttgcgct cggaggtctg      540

acctcgtcga tctttaacga ggtcgtgcag ttcttcttga tttgggctgg tttgctgccc      600

atcccgctca tcggcctgca caatctgggc ggatggcagg gcatgatgtc ccggctgccc      660

gcggggttcg gacatctttg ggcgaacctg ggttccccgt ctcacaaccc gatgggaatt      720

ggctggcttg gcgtggtgct cgggctcggt tttgtgctct cgttcgggta ctggacgacg      780

gacttcttgg tcgttcagcg caccctcgcg gcgaaggatc tgcgcgcggc ccaattgacg      840

ccgatttacg cagcgttctt taagatgatt gttccgattc tggtgatcat cccggggctg      900

attgcgctcg ccatctttcc gaagatcggc cattcgccga acatgagcta caacctggcg      960

ctgcccctgc tcatcgccaa atactatccg cctggcatgc tcgggcttgg actgacggcc     1020

atgctcgcga gcttcatgag cggtatggcg ggcaatgtca ccgcgtttac gacggtttgg     1080

acgtatgata tctatcaggc gtacatcaag aaggacgcac cggacaagca ctatgtgaac     1140

atggggcgct gggcggtcgt ggtcggcgtc atcatcagca tcggcaccgc ctacttcgcg     1200

gccggtttcc cgagcgtcat ggattacatg cagacgctgt tctcgttctt caacgcgccg     1260

ctgttcgcca cgttcttgtt ggggatgttc tggaaaaagg ccacgccttg gggcggtttc     1320

tggggcctgc tcgcgggtat cgccggcgcg ttcgccatgt acttcttcct gcccgcgcat     1380

atgttctcga gcccggatgc aggtaacttc tggcgcgcat ggtgggcctg ggtgatcacg     1440

gtcgtcgtga ccgtcttggt aagccttgtg acgcagggca agcggcccga agagctggaa     1500

ggcctcgtgt acggcctcag caagcggccc gactacagcg gttatccgtg gtacaagcgc     1560

ccgggttacc tggcggccat cgtgttcgtg atcctggtgg gcctgaatat cgcgttctgg     1620

tga                                                                   1623


<210>   105
<211>   533
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   105
Val Asp Tyr Leu Ile Ile Gly Ile Tyr Phe Leu Phe Val Leu Gly Ile 
                5                   10                  15      

Gly Ala Leu Leu Arg Asp Lys Met Arg Thr Ser Glu Asp Tyr Phe Leu 
            20                  25                  30          

Ser Gly Arg Ser Leu Pro Ser Trp Val Thr Gly Leu Ala Phe Leu Gly 
        35                  40                  45              

Ala Asn Leu Gly Ala Leu Glu Ile Leu Gly Met Gly Ala Gly Ala Ala 
    50                  55                  60                  

Gln Tyr Gly Leu Met Gln Ala His Phe Tyr Trp Ile Gly Ala Ile Pro 
65                  70                  75                  80  

Ala Met Val Phe Val Ala Leu Phe Met Ile Pro Phe Tyr Tyr Gly Ser 
                85                  90                  95      

Arg Val His Ser Val Pro Gly Tyr Leu Lys Leu Arg Tyr Asn Glu Ala 
            100                 105                 110         

Thr Arg Gly Phe Asn Ala Val Leu Phe Ala Ile Phe Met Ile Leu Leu 
        115                 120                 125             

Ser Gly Ile Asn Met Tyr Ala Met Ala Ile Val Phe Lys Leu Leu Leu 
    130                 135                 140                 

Gly Trp Ser Leu Thr Ala Ser Ile Leu Leu Ser Ala Ala Ile Thr Met 
145                 150                 155                 160 

Ala Tyr Ile Leu Leu Gly Gly Leu Ser Ser Ser Ile Tyr Asn Glu Val 
                165                 170                 175     

Leu Gln Phe Phe Leu Ile Thr Leu Gly Leu Val Pro Leu Val Val Phe 
            180                 185                 190         

Ala Leu Ile Asp Val Gly Gly Trp Ala Gly Leu Gln Glu Ala Val Asp 
        195                 200                 205             

Arg Glu Gly Tyr Phe His Leu Trp Ala His Thr Gly Thr Thr Asp Asn 
    210                 215                 220                 

Pro Met Ala Val Arg Trp Phe Gly Ile Val Leu Gly Leu Gly Phe Val 
225                 230                 235                 240 

Leu Ser Phe Gly Tyr Trp Cys Thr Asp Phe Leu Val Val Gln Arg Ala 
                245                 250                 255     

Leu Ala Ala Glu Asp Ala Ala Ala Ala Gln Arg Thr Pro Leu Ile Ala 
            260                 265                 270         

Ala Phe Pro Lys Leu Leu Tyr Gly Ile Leu Ala Ile Phe Pro Gly Leu 
        275                 280                 285             

Val Ala Leu Thr Ile Val Pro Asn Leu Gly Gln Gly Gly Gly Gly Leu 
    290                 295                 300                 

Ala Asn Ser Tyr Asn Met Ala Ile Pro Tyr Ala Met Ala His Tyr Phe 
305                 310                 315                 320 

Pro Ser Gly Met Leu Gly Leu Gly Leu Thr Ala Leu Leu Ala Ala Phe 
                325                 330                 335     

Met Ser Gly Met Ala Gly Asn Val Thr Ala Phe Asn Thr Val Trp Thr 
            340                 345                 350         

Tyr Asp Ile Tyr Arg Ser Tyr Ile Arg Arg Asp Ala Pro Asp Arg His 
        355                 360                 365             

Tyr Leu Asn Met Gly Arg Ile Ala Thr Val Ala Gly Val Val Leu Ser 
    370                 375                 380                 

Val Gly Thr Ala Tyr Ile Val Leu Gly Phe Ala Ser Ile Met Asp Tyr 
385                 390                 395                 400 

Val Gln Leu Leu His Gly Leu Phe Leu Ala Pro Leu Phe Gly Thr Phe 
                405                 410                 415     

Leu Leu Gly Met Phe Trp Lys Arg Thr Thr Pro Trp Gly Gly Phe Ala 
            420                 425                 430         

Gly Leu Val Ser Gly Thr Ala Ala Gly Leu Val Leu Tyr Gly Leu Glu 
        435                 440                 445             

Leu Leu Gly Thr Ile Gln Tyr Gly Ala Pro Met Ala Gly Asn Phe Trp 
    450                 455                 460                 

Arg Ala Trp Trp Ala Trp Leu Val Cys Phe Val Val Thr Ile Ala Val 
465                 470                 475                 480 

Ser Leu Val Thr Arg Pro Lys Glu Glu Arg Glu Leu Arg Gly Leu Val 
                485                 490                 495     

Tyr Gly Leu Thr Glu Lys Lys Glu Gly Val Glu Gln Ala Trp Tyr Lys 
            500                 505                 510         

Lys Pro Gly Val Leu Ala Ala Ala Val Leu Leu Ile Thr Leu Val Leu 
        515                 520                 525             

Asn Val Ile Phe Phe 
    530             

<210>   106
<211>   555
<212>   PRT
<213>   Acidobacteria bacterium Ellin345

<400>   106
Leu Val Asn Leu Ser Ser Thr Asp Leu Val Ile Ile Val Phe Tyr Phe 
                5                   10                  15      

Ala Leu Val Leu Ala Ile Gly Trp Gln Leu Lys Gly Gln Ala Lys Thr 
            20                  25                  30          

Gly Glu Asp Phe Phe Met Ala Gly Arg Glu Met Thr Ala Trp Ile Ala 
        35                  40                  45              

Gly Leu Ser Phe Leu Ser Ala Asn Leu Gly Ser Leu Glu Leu Met Gly 
    50                  55                  60                  

Trp Ala Gly Ala Ala Tyr Gln Tyr Gly Ile Leu Ala Ala His Trp Tyr 
65                  70                  75                  80  

Trp Ile Gly Ala Ile Pro Ala Met Ile Phe Leu Gly Leu Val Met Met 
                85                  90                  95      

Pro Phe Tyr Tyr Ile Ser Lys Thr His Ser Val Pro Gly Tyr Leu Lys 
            100                 105                 110         

Leu Arg Phe Gly Glu Pro Ser Arg Ala Leu Ser Ala Val Ser Phe Ala 
        115                 120                 125             

Phe Met Thr Val Leu Met Ser Gly Ile Asn Met Tyr Ser Met Ala Leu 
    130                 135                 140                 

Val Met Lys Val Val Leu Gly Trp Asp Ile Asn Val Ser Ile Ile Val 
145                 150                 155                 160 

Ser Ser Ile Thr Val Ala Ile Tyr Val Thr Leu Gly Gly Leu Arg Ser 
                165                 170                 175     

Ala Ile Phe Asn Glu Val Leu Gln Phe Ile Leu Ile Trp Ala Gly Ala 
            180                 185                 190         

Leu Leu Ile Pro Ile Met Gly Leu Ile Glu Ala Gly Gly Trp Thr Asn 
        195                 200                 205             

Leu Lys Ala Gln Ile Thr Arg Asn Ala Ser Ala Glu Tyr Thr His Leu 
    210                 215                 220                 

Trp Ser Thr Leu Gly Lys Phe Ser Asp Asn Pro Met Gly Ile Asn Trp 
225                 230                 235                 240 

Ile Gly Ile Val Phe Gly Leu Gly Ala Ile Ile Ser Met Gly Tyr Trp 
                245                 250                 255     

Thr Thr Asp Phe Leu Val Val Gln Arg Val Leu Ala Ala Lys Asp Met 
            260                 265                 270         

Arg Ser Ala Lys Met Ala Pro Ile Ile Gly Ala Ala Phe Lys Met Leu 
        275                 280                 285             

Val Pro Phe Ile Val Ile Leu Pro Gly Leu Leu Ala Leu Ala Val Leu 
    290                 295                 300                 

Pro Met Lys Leu Val Gly Glu Ser Gln Ala Ile Ala Thr His Gly His 
305                 310                 315                 320 

Ser Tyr Asn Glu Val Leu Pro Leu Met Leu Ala Arg Tyr Cys Gly Pro 
                325                 330                 335     

Gly Leu Leu Gly Leu Gly Ile Thr Ala Leu Ile Ala Gly Phe Met Ser 
            340                 345                 350         

Gly Met Ala Gly Asn Val Ser Ala Phe Thr Thr Val Trp Thr Tyr Asp 
        355                 360                 365             

Ile Tyr Arg Ala Met Ile Lys Lys Asp Ala Ser Asp Ala His Tyr Val 
    370                 375                 380                 

Asn Met Gly Arg Ala Ser Thr Ile Gly Gly Val Ile Ile Ser Ile Leu 
385                 390                 395                 400 

Thr Ala Tyr Phe Val Met Lys Phe Ala Ser Ile Met Asp Tyr Val Gln 
                405                 410                 415     

Ala Leu Phe Ser Phe Phe Ile Ala Pro Leu Phe Ala Thr Val Val Leu 
            420                 425                 430         

Gly Met Leu Trp Lys Arg Ala Thr Asn Ala Gly Gly Phe Trp Gly Leu 
        435                 440                 445             

Leu Ala Gly Thr Val Ser Ser Val Gly Met Tyr Ala Trp Val Lys Leu 
    450                 455                 460                 

Asp Pro Ser Ala Leu Arg Tyr Val Ala Met Ser Pro Asp Ala Gln Ala 
465                 470                 475                 480 

Met Ala Glu Asn Met Tyr Arg Ala Leu Trp Ser Cys Leu Ile Cys Ala 
                485                 490                 495     

Leu Val Thr Val Val Val Ser Tyr Ala Thr Lys Pro Arg Pro Asp Ala 
            500                 505                 510         

Glu Leu Val Gly Leu Val Lys Ser Val Thr Pro Ile Pro Ser Glu Gly 
        515                 520                 525             

Asp Val Pro Met Tyr Met Arg Pro Ala Phe Trp Ala Cys Val Val Ala 
    530                 535                 540                 

Val Gly Phe Ile Ile Leu Gln Ile Ile Phe Trp 
545                 550                 555 

<210>   107
<211>   556
<212>   PRT
<213>   Solibacter usitatus Ellin6076

<400>   107
Leu Met Thr Leu Ser Thr Val Asp Leu Ala Ile Ile Val Leu Tyr Phe 
                5                   10                  15      

Ala Ala Val Leu Gly Ile Gly Phe Tyr Leu Lys Arg Phe Thr Lys Thr 
            20                  25                  30          

Gly Glu Asp Phe Phe Leu Ala Gly Arg Glu Met Thr Ala Trp Ile Ala 
        35                  40                  45              

Gly Leu Ser Phe Leu Ala Ala Asn Leu Gly Ser Leu Glu Leu Met Gly 
    50                  55                  60                  

Trp Ala Ala Ser Ala Tyr Gln Tyr Gly Ile Leu Ala Thr His Trp Tyr 
65                  70                  75                  80  

Trp Ile Gly Ala Ile Pro Ala Met Leu Phe Leu Gly Ile Val Met Ile 
                85                  90                  95      

Pro Phe Tyr Tyr Ile Ser Lys Thr His Ser Val Pro Gly Tyr Leu Lys 
            100                 105                 110         

Leu Arg Phe Gly Glu Pro Ala Arg Ala Leu Ser Ala Ile Ser Phe Gly 
        115                 120                 125             

Leu Met Thr Val Phe Met Ser Gly Ile Asn Met Tyr Ser Met Ala Leu 
    130                 135                 140                 

Val Met Lys Val Val Leu Gly Trp Asp Ile His Val Ser Ile Trp Ile 
145                 150                 155                 160 

Ser Ser Ile Thr Val Met Leu Tyr Val Gly Leu Gly Gly Leu Leu Ser 
                165                 170                 175     

Ala Ile Phe Asn Glu Val Leu Gln Phe Val Leu Ile Trp Leu Gly Ala 
            180                 185                 190         

Met Leu Ile Ser Ile Ile Gly Leu Ile Glu Ala Gly Gly Trp Asp Gly 
        195                 200                 205             

Met Val Ala Lys Ile His Ala Asn Phe Pro Gln Gly Asp Tyr Thr His 
    210                 215                 220                 

Ala Trp Arg Thr Leu Gly Ser Phe Asn Asp Asn Pro Met Gly Ile Asn 
225                 230                 235                 240 

Trp Val Gly Ile Val Phe Gly Leu Gly Ala Val Ile Ser Met Gly Tyr 
                245                 250                 255     

Trp Thr Thr Asp Phe Leu Val Val Gln Arg Val Ile Ser Ala Lys Asp 
            260                 265                 270         

Leu Arg Ala Ala Lys Leu Ala Pro Ile Ile Gly Ala Ala Phe Lys Met 
        275                 280                 285             

Cys Val Pro Phe Ile Val Ile Leu Pro Gly Leu Leu Gly Leu Ala Val 
    290                 295                 300                 

Leu Pro Glu His Leu Leu Pro Glu Ser Gln Ala Leu Ala Thr Gly Gly 
305                 310                 315                 320 

His Ser Tyr Asn Glu Val Leu Pro Ile Met Leu Ala Arg Tyr Cys Gly 
                325                 330                 335     

Pro Gly Leu Leu Gly Leu Gly Ile Thr Ala Leu Ile Ala Gly Phe Met 
            340                 345                 350         

Ser Gly Met Ala Gly Asn Val Ser Ala Phe Ala Thr Val Trp Thr Tyr 
        355                 360                 365             

Asp Val Tyr Arg Ala Met Phe Asn Lys Asn Ala Thr Asp Ser His Tyr 
    370                 375                 380                 

Val Ser Val Gly Arg Trp Cys Thr Phe Trp Gly Val Leu Ala Ser Ile 
385                 390                 395                 400 

Gly Thr Ala Tyr Met Val Met Ser Phe Ala Ser Ile Met Asp Tyr Val 
                405                 410                 415     

Gln Ala Leu Phe Ser Phe Phe Ile Ala Pro Leu Phe Gly Thr Val Ile 
            420                 425                 430         

Leu Gly Met Leu Trp Lys Arg Ala Ser Pro Ala Gly Gly Phe Trp Gly 
        435                 440                 445             

Leu Ala Ala Gly Thr Ala Ser Ser Ile Gly Met Trp Ala Trp Val Lys 
    450                 455                 460                 

Ile Asp His Thr Ala Ile Gln Tyr Val Ala Met Ser Pro Asn Ala Lys 
465                 470                 475                 480 

Asp Met Ala Glu Asn Met Phe Arg Ala Leu Trp Ser Trp Leu Val Cys 
                485                 490                 495     

Val Ile Val Thr Val Val Val Ser Leu Met Thr Lys Pro Lys Pro Glu 
            500                 505                 510         

Lys Glu Leu Val Asn Leu Val Tyr Gly Cys Thr Asp Ile Pro Ser Glu 
        515                 520                 525             

Gly His Leu Pro Val Trp Gln Arg Pro Ala Phe Trp Ala Cys Val Val 
    530                 535                 540                 

Gly Ala Val Phe Ile Ala Leu Asn Ile Ile Phe Trp 
545                 550                 555     

<210>   108
<211>   553
<212>   PRT
<213>   Solibacter usitatus Ellin6076

<400>   108
Ala Val Asp Tyr Ala Ile Leu Ala Leu Tyr Phe Ala Phe Val Leu Gly 
                5                   10                  15      

Ile Gly Trp Arg Leu Arg Lys Lys Ile Ser Thr Ser Gly Asp Phe Leu 
            20                  25                  30          

Thr Ser Gly His Ser Val Pro Val Trp Ile Thr Ser Leu Ala Phe Leu 
        35                  40                  45              

Ala Ala Asn Leu Gly Ala Gln Glu Leu Val Gly Met Ser Gly Asn Gly 
    50                  55                  60                  

Ala Lys Tyr Gly Ile Met Thr Ala His Phe Tyr Trp Val Gly Ala Val 
65                  70                  75                  80  

Pro Ala Met Ile Phe Val Gly Ile Phe Met Met Pro Phe Tyr Tyr Gly 
                85                  90                  95      

Ser Arg Ala Arg Ser Val Pro Glu Tyr Leu Lys Leu Arg Phe Asp Glu 
            100                 105                 110         

Lys Thr Arg Ala Leu Asn Ala Leu Thr Phe Ala Gly Met Thr Ile Phe 
        115                 120                 125             

Ser Ser Gly Ile Ser Met Tyr Ala Leu Gly Leu Leu Leu Arg Leu Val 
    130                 135                 140                 

Leu Gly Trp Asp Phe Thr Thr Ser Val Leu Cys Ser Ala Ala Ile Val 
145                 150                 155                 160 

Leu Ala Tyr Thr Phe Leu Gly Gly Leu Thr Ser Ala Ile Tyr Asn Glu 
                165                 170                 175     

Val Leu Gln Phe Phe Leu Ile Val Met Gly Phe Ser Pro Leu Ala Ile 
            180                 185                 190         

Met Ala Val Met Lys Ala Gly Gly Trp Ser Gly Met Ser Ala Arg Leu 
        195                 200                 205             

Ala Gln Met Thr Leu Pro Gly Gly Ile Asn Gly Ser Val Met Thr His 
    210                 215                 220                 

Ser Trp Lys Tyr Met Ala His Thr Ser Glu Asn Pro Met Gly Ile Glu 
225                 230                 235                 240 

Ile Phe Gly Leu Val Ala Gly Leu Gly Phe Val Met Ser Phe Gly Tyr 
                245                 250                 255     

Trp Cys Thr Asp Phe Leu Val Ile Gln Arg Ala Met Ala Ala Asn Ser 
            260                 265                 270         

Met Ser Ala Ser Arg Arg Thr Pro Val Ile Ala Ala Leu Pro Lys Met 
        275                 280                 285             

Met Met Pro Phe Ile Val Ile Val Pro Gly Ile Ala Ala Leu Ala Leu 
    290                 295                 300                 

Ser Gln Met Gly Val Gly Tyr Asp Leu Pro Met Lys Asn Gly Gly Pro 
305                 310                 315                 320 

Asp Tyr Asp Gln Val Leu Thr Thr Leu Met Gly Lys Phe Tyr Pro Ala 
                325                 330                 335     

Gly Met Leu Gly Val Gly Leu Thr Gly Leu Met Ala Ser Phe Met Ser 
            340                 345                 350         

Gly Met Ala Gly Asn Val Thr Ala Phe Asn Thr Val Phe Thr Tyr Asp 
        355                 360                 365             

Leu Tyr Gln Thr Tyr Ile Lys Pro Gly Gln Pro Asp His His Tyr Leu 
    370                 375                 380                 

Thr Val Gly Arg Ile Thr Thr Val Val Gly Val Ala Leu Ser Ile Cys 
385                 390                 395                 400 

Thr Ala Tyr Leu Ala Gln Gln Tyr Asn Ser Ile Asn Asp Leu Leu Gln 
                405                 410                 415     

Leu Val Phe Ser Phe Val Asn Ala Pro Leu Phe Gly Thr Phe Leu Leu 
            420                 425                 430         

Gly Met Phe Trp Lys Arg Thr Thr Gly His Gly Ala Phe Phe Gly Leu 
        435                 440                 445             

Leu Ser Gly Thr Ala Ala Ala Ala Leu Thr Gln Gly Leu Thr Val Ala 
    450                 455                 460                 

Glu Gly Lys Gly Gly Trp Met Ala Asn Leu His Glu Phe Pro Ser Ser 
465                 470                 475                 480 

Met Ala Gln Asn Phe Trp Ile Ala Ile Thr Ala Trp Thr Val Cys Phe 
                485                 490                 495     

Ala Ile Thr Ile Ala Val Ser Met Val Thr Thr Pro Arg Pro Glu Lys 
            500                 505                 510         

Glu Leu His Gly Leu Val Tyr Gly Leu Thr Glu Leu Lys His Asp Glu 
        515                 520                 525             

Gly Val Ser Trp Tyr Leu Arg Pro Val Pro Leu Ala Ile Ala Ile Gly 
    530                 535                 540                 

Ala Leu Ala Leu Phe Leu Asn Phe Trp 
545                 550             

<210>   109
<211>   554
<212>   PRT
<213>   Saccharopolyspora erythraea NRRL 2338

<400>   109
Gln Val Glu Leu Arg Leu Asp Ala Ser Ala Val Asp Tyr Val Leu Leu 
                5                   10                  15      

Ala Ile Tyr Phe Val Phe Val Leu Gly Ile Gly Tyr Leu Ala Arg Arg 
            20                  25                  30          

Ser Val Ser Thr Ser Leu Asp Phe Phe Leu Ser Gly Arg Ala Leu Pro 
        35                  40                  45              

Ala Trp Val Thr Gly Leu Ala Phe Ile Ala Ala Asn Leu Gly Ala Ile 
    50                  55                  60                  

Glu Ile Ile Gly Met Ser Ala Asn Gly Ala Glu Tyr Gly Met Pro Thr 
65                  70                  75                  80  

Met His Tyr Phe Trp Ile Gly Ala Val Pro Ala Met Leu Phe Leu Gly 
                85                  90                  95      

Ile Val Met Met Pro Phe Tyr Tyr Gly Ser Lys Val Arg Ser Val Pro 
            100                 105                 110         

Glu Phe Met Leu Arg Arg Phe Gly Lys Pro Ala His Leu Val Asn Gly 
        115                 120                 125             

Ile Ser Phe Ala Val Ala Gln Val Leu Ile Ala Gly Val Asn Leu Tyr 
    130                 135                 140                 

Leu Leu Ala Ser Ile Val Asn Val Leu Leu Gly Trp Pro Leu Trp Val 
145                 150                 155                 160 

Ser Val Leu Ile Ala Ala Ala Ile Val Leu Ser Tyr Thr Ala Leu Gly 
                165                 170                 175     

Gly Leu Ser Ala Ala Ile Tyr Asn Glu Val Leu Gln Phe Phe Val Ile 
            180                 185                 190         

Val Ala Ala Leu Leu Pro Leu Thr Ile Val Gly Leu Thr Lys Val Gly 
        195                 200                 205             

Gly Trp Glu Gly Leu Val Ala Lys Val Ser Ala Ser Pro Gly Gly Ala 
    210                 215                 220                 

Glu Gln Leu Thr Ala Trp Pro Gly Asn Glu Leu Thr Gly Phe Thr Asn 
225                 230                 235                 240 

Ser Phe Leu Ser Val Val Gly Leu Val Phe Gly Leu Gly Phe Val Leu 
                245                 250                 255     

Ser Phe Gly Tyr Trp Thr Thr Asn Phe Val Glu Val Gln Arg Ala Met 
            260                 265                 270         

Ala Ser Lys Ser Met Ser Ala Ala Gln Arg Thr Pro Ile Ile Gly Ala 
        275                 280                 285             

Phe Pro Lys Met Phe Ile Pro Phe Leu Val Ile Ile Pro Gly Met Ile 
    290                 295                 300                 

Ala Ala Val Leu Val Pro Asp Leu Ser Ala Tyr Lys Ala Thr Gly Ala 
305                 310                 315                 320 

Gly Ala Val Asp Tyr Asn Asp Ala Leu Leu Leu Leu Met Arg Asp Leu 
                325                 330                 335     

Leu Pro Asn Gly Leu Leu Gly Ile Ala Leu Ala Gly Leu Leu Ala Ser 
            340                 345                 350         

Phe Met Ala Gly Met Ala Ala Asn Leu Ser Ser Phe Asn Thr Val Phe 
        355                 360                 365             

Thr Tyr Asp Leu Trp Gln Ala Tyr Ile Val Lys Asp Lys Pro Asp His 
    370                 375                 380                 

Tyr Tyr Leu Asn Met Gly Arg Trp Val Thr Val Gly Ala Thr Val Val 
385                 390                 395                 400 

Ala Val Gly Thr Ala Phe Ile Ala Ala Gly Tyr Glu Asn Leu Met Asp 
                405                 410                 415     

Tyr Leu Gln Gln Leu Phe Ser Phe Phe Asn Ala Pro Leu Phe Ala Thr 
            420                 425                 430         

Phe Ile Leu Gly Met Phe Trp Lys Arg Met Thr Pro Thr Ala Gly Trp 
        435                 440                 445             

Leu Gly Leu Val Leu Gly Thr Leu Ala Ala Val Thr Val Phe Gly Leu 
    450                 455                 460                 

Ser Glu Gly Gly Val Leu Asp Leu Pro Gly Gln Gly Ala Ser Phe Val 
465                 470                 475                 480 

Gly Ala Gly Ala Ala Phe Val Val Asp Ile Val Val Ser Val Leu Val 
                485                 490                 495     

Ser Met Ala Thr Arg Pro Lys Ala Asp Thr Glu Leu Val Gly Leu Val 
            500                 505                 510         

Tyr Ser Leu Thr Pro Lys Glu Ser Arg Thr Ala Ser Thr Ser Gly Glu 
        515                 520                 525             

Asp Ala Gly Trp Tyr Arg Arg Pro Gly Leu Leu Ala Gly Ile Val Leu 
    530                 535                 540                 

Val Ile Thr Val Leu Leu Asn Ile Ile Phe 
545                 550                 

<210>   110
<211>   540
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   110
Met His Arg Val His Ala Leu Phe His Ala Asn Ala Val Asp Tyr Ile 
                5                   10                  15      

Ile Ile Leu Val Tyr Phe Ala Phe Val Leu Gly Val Gly Phe Val Leu 
            20                  25                  30          

Arg Asn Arg Val Arg Thr Gly Glu Asp Phe Phe Leu Ser Gly Arg Ser 
        35                  40                  45              

Ile Pro Ala Trp Ile Thr Gly Leu Ala Phe Leu Ser Ala Asn Leu Gly 
    50                  55                  60                  

Ala Leu Glu Ile Leu Gly Met Thr Ala Ser Gly Ala Glu Tyr Gly Met 
65                  70                  75                  80  

Leu Thr Thr His Phe Tyr Trp Ile Gly Ala Leu Pro Ala Met Leu Phe 
                85                  90                  95      

Leu Gly Leu Tyr Met Met Pro Phe Tyr Tyr Val Ser Lys Val Arg Ser 
            100                 105                 110         

Val Pro Glu Phe Leu Lys Leu Arg Tyr Asn Glu Ala Thr Arg Ala Leu 
        115                 120                 125             

Asn Ala Ile Ala Phe Ala Val Met Thr Val Leu Thr Ser Gly Ile Ser 
    130                 135                 140                 

Leu Tyr Ser Met Ala Leu Ile Phe Gln Ile Leu Ile Gly Trp Ser Phe 
145                 150                 155                 160 

Asp Thr Ser Ile Leu Val Ser Ala Leu Val Val Leu Ile Tyr Val Ala 
                165                 170                 175     

Leu Gly Gly Leu Thr Ser Ser Ile Phe Asn Glu Val Val Gln Phe Phe 
            180                 185                 190         

Leu Ile Trp Ala Gly Leu Leu Pro Ile Pro Leu Ile Gly Leu His Asn 
        195                 200                 205             

Leu Gly Gly Trp Gln Gly Met Met Ser Arg Leu Pro Ala Gly Phe Gly 
    210                 215                 220                 

His Leu Trp Ala Asn Leu Gly Ser Pro Ser His Asn Pro Met Gly Ile 
225                 230                 235                 240 

Gly Trp Leu Gly Val Val Leu Gly Leu Gly Phe Val Leu Ser Phe Gly 
                245                 250                 255     

Tyr Trp Thr Thr Asp Phe Leu Val Val Gln Arg Thr Leu Ala Ala Lys 
            260                 265                 270         

Asp Leu Arg Ala Ala Gln Leu Thr Pro Ile Tyr Ala Ala Phe Phe Lys 
        275                 280                 285             

Met Ile Val Pro Ile Leu Val Ile Ile Pro Gly Leu Ile Ala Leu Ala 
    290                 295                 300                 

Ile Phe Pro Lys Ile Gly His Ser Pro Asn Met Ser Tyr Asn Leu Ala 
305                 310                 315                 320 

Leu Pro Leu Leu Ile Ala Lys Tyr Tyr Pro Pro Gly Met Leu Gly Leu 
                325                 330                 335     

Gly Leu Thr Ala Met Leu Ala Ser Phe Met Ser Gly Met Ala Gly Asn 
            340                 345                 350         

Val Thr Ala Phe Thr Thr Val Trp Thr Tyr Asp Ile Tyr Gln Ala Tyr 
        355                 360                 365             

Ile Lys Lys Asp Ala Pro Asp Lys His Tyr Val Asn Met Gly Arg Trp 
    370                 375                 380                 

Ala Val Val Val Gly Val Ile Ile Ser Ile Gly Thr Ala Tyr Phe Ala 
385                 390                 395                 400 

Ala Gly Phe Pro Ser Val Met Asp Tyr Met Gln Thr Leu Phe Ser Phe 
                405                 410                 415     

Phe Asn Ala Pro Leu Phe Ala Thr Phe Leu Leu Gly Met Phe Trp Lys 
            420                 425                 430         

Lys Ala Thr Pro Trp Gly Gly Phe Trp Gly Leu Leu Ala Gly Ile Ala 
        435                 440                 445             

Gly Ala Phe Ala Met Tyr Phe Phe Leu Pro Ala His Met Phe Ser Ser 
    450                 455                 460                 

Pro Asp Ala Gly Asn Phe Trp Arg Ala Trp Trp Ala Trp Val Ile Thr 
465                 470                 475                 480 

Val Val Val Thr Val Leu Val Ser Leu Val Thr Gln Gly Lys Arg Pro 
                485                 490                 495     

Glu Glu Leu Glu Gly Leu Val Tyr Gly Leu Ser Lys Arg Pro Asp Tyr 
            500                 505                 510         

Ser Gly Tyr Pro Trp Tyr Lys Arg Pro Gly Tyr Leu Ala Ala Ile Val 
        515                 520                 525             

Phe Val Ile Leu Val Gly Leu Asn Ile Ala Phe Trp 
    530                 535                 540 

<210>   111
<211>   540
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   111
Met His Arg Val His Ala Ile Phe His Ala Asn Ala Val Asp Tyr Ile 
                5                   10                  15      

Ile Ile Leu Val Tyr Phe Ala Phe Val Leu Gly Val Gly Phe Val Leu 
            20                  25                  30          

Arg Asn Arg Val Arg Thr Gly Glu Asp Phe Phe Leu Ser Gly Arg Ser 
        35                  40                  45              

Ile Pro Ala Trp Ile Thr Gly Leu Ala Phe Leu Ser Ala Asn Leu Gly 
    50                  55                  60                  

Ala Leu Glu Ile Leu Gly Met Thr Ala Ser Gly Ala Glu Tyr Gly Met 
65                  70                  75                  80  

Leu Thr Thr His Phe Tyr Trp Ile Gly Ala Ile Pro Ala Met Leu Phe 
                85                  90                  95      

Leu Gly Leu Tyr Met Met Pro Phe Tyr Tyr Val Ser Lys Val Arg Ser 
            100                 105                 110         

Val Pro Glu Phe Leu Lys Leu Arg Tyr Asn Glu Ala Thr Arg Ala Leu 
        115                 120                 125             

Asn Ala Ile Ala Phe Ala Val Met Thr Val Leu Thr Ser Gly Ile Ser 
    130                 135                 140                 

Leu Tyr Ser Met Ala Leu Ile Phe Gln Ile Leu Ile Gly Trp Ser Phe 
145                 150                 155                 160 

Asp Thr Ser Ile Leu Val Ser Ala Leu Val Val Leu Ile Tyr Val Ala 
                165                 170                 175     

Leu Gly Gly Leu Thr Ser Ser Ile Phe Asn Glu Val Val Gln Phe Phe 
            180                 185                 190         

Leu Ile Trp Ala Gly Leu Leu Pro Ile Pro Leu Ile Gly Leu His Asn 
        195                 200                 205             

Leu Gly Gly Trp Gln Gly Met Met Ser Arg Leu Pro Ala Gly Phe Gly 
    210                 215                 220                 

His Leu Trp Ala Asn Leu Gly Ser Pro Ser His Asn Pro Met Gly Ile 
225                 230                 235                 240 

Gly Trp Leu Gly Val Val Leu Gly Leu Gly Phe Val Leu Ser Phe Gly 
                245                 250                 255     

Tyr Trp Thr Thr Asp Phe Leu Val Val Gln Arg Thr Leu Ala Ala Lys 
            260                 265                 270         

Asp Leu Arg Ala Ala Gln Leu Thr Pro Ile Tyr Ala Ala Phe Phe Lys 
        275                 280                 285             

Met Ile Val Pro Ile Leu Val Ile Ile Pro Gly Leu Ile Ala Leu Ala 
    290                 295                 300                 

Ile Phe Pro Lys Ile Gly His Ser Pro Asn Met Ser Tyr Asn Leu Ala 
305                 310                 315                 320 

Leu Pro Leu Leu Ile Ala Lys Tyr Tyr Pro Pro Gly Met Leu Gly Leu 
                325                 330                 335     

Gly Leu Thr Ala Met Leu Ala Ser Phe Met Ser Gly Met Ala Gly Asn 
            340                 345                 350         

Val Thr Ala Phe Thr Thr Val Trp Thr Tyr Asp Ile Tyr Gln Ala Tyr 
        355                 360                 365             

Ile Lys Lys Asp Ala Pro Asp Lys His Tyr Val Asn Met Gly Arg Trp 
    370                 375                 380                 

Ala Val Val Val Gly Val Ile Ile Ser Ile Gly Thr Ala Tyr Phe Ala 
385                 390                 395                 400 

Ala Gly Phe Pro Ser Val Met Asp Tyr Met Gln Thr Leu Phe Ser Phe 
                405                 410                 415     

Phe Asn Ala Pro Leu Phe Ala Thr Phe Leu Leu Gly Met Phe Trp Lys 
            420                 425                 430         

Lys Ala Thr Pro Trp Gly Gly Phe Trp Gly Leu Leu Ala Gly Ile Ala 
        435                 440                 445             

Gly Ala Phe Ala Met Tyr Phe Phe Leu Pro Ala His Met Phe Ser Ser 
    450                 455                 460                 

Pro Asp Ala Gly Asn Phe Trp Arg Ala Trp Trp Ala Trp Val Ile Thr 
465                 470                 475                 480 

Val Val Val Thr Val Leu Val Ser Leu Val Thr Gln Gly Lys Arg Pro 
                485                 490                 495     

Glu Glu Leu Glu Gly Leu Val Tyr Gly Leu Ser Lys Arg Pro Asp Tyr 
            500                 505                 510         

Ser Gly Tyr Pro Trp Tyr Lys Arg Pro Gly Tyr Leu Ala Ala Ile Val 
        515                 520                 525             

Phe Val Ile Leu Val Gly Leu Asn Ile Ala Phe Trp 
    530                 535                 540 

<210>   112
<211>   540
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   112
Met His Arg Val His Ala Leu Phe His Ala Asn Ala Val Asp Tyr Ile 
                5                   10                  15      

Ile Ile Leu Val Tyr Phe Ala Phe Val Leu Gly Val Gly Phe Val Leu 
            20                  25                  30          

Arg Asn Arg Val Arg Thr Gly Glu Asp Phe Phe Leu Ser Gly Arg Ser 
        35                  40                  45              

Ile Pro Ala Trp Ile Thr Gly Leu Ala Phe Leu Ser Ala Asn Leu Gly 
    50                  55                  60                  

Ala Leu Glu Ile Leu Gly Met Thr Ala Ser Gly Ala Glu Tyr Gly Met 
65                  70                  75                  80  

Leu Thr Thr His Phe Tyr Trp Ile Gly Ala Ile Pro Ala Met Leu Phe 
                85                  90                  95      

Leu Gly Leu Tyr Met Met Pro Phe Tyr Tyr Val Ser Lys Val Arg Ser 
            100                 105                 110         

Val Pro Glu Phe Leu Lys Leu Arg Tyr Gln Glu Ala Thr Arg Ala Leu 
        115                 120                 125             

Asn Ala Ile Ala Phe Ala Val Met Thr Val Leu Thr Ser Gly Ile Ser 
    130                 135                 140                 

Leu Tyr Ser Met Ala Leu Ile Phe Gln Ile Leu Ile Gly Trp Ser Phe 
145                 150                 155                 160 

Asp Thr Ser Ile Leu Val Ser Ala Leu Val Val Leu Ile Tyr Val Ala 
                165                 170                 175     

Leu Gly Gly Leu Thr Ser Ser Ile Phe Asn Glu Val Val Gln Phe Phe 
            180                 185                 190         

Leu Ile Trp Ala Gly Leu Leu Pro Ile Pro Leu Ile Gly Leu His Asn 
        195                 200                 205             

Leu Gly Gly Trp Gln Gly Met Met Ser Arg Leu Pro Ala Gly Phe Gly 
    210                 215                 220                 

His Leu Trp Ala Asn Leu Gly Ser Pro Ser His Asn Pro Met Gly Ile 
225                 230                 235                 240 

Gly Trp Leu Gly Val Val Leu Gly Leu Gly Phe Val Leu Ser Phe Gly 
                245                 250                 255     

Tyr Trp Thr Thr Asp Phe Leu Val Val Gln Arg Thr Leu Ala Ala Lys 
            260                 265                 270         

Asp Leu Arg Ala Ala Gln Leu Thr Pro Ile Tyr Ala Ala Phe Phe Lys 
        275                 280                 285             

Met Ile Val Pro Ile Leu Val Ile Ile Pro Gly Leu Ile Ala Leu Ala 
    290                 295                 300                 

Ile Phe Pro Lys Ile Gly His Ser Pro Asn Met Ser Tyr Asn Leu Ala 
305                 310                 315                 320 

Leu Pro Leu Leu Ile Ala Lys Tyr Tyr Pro Pro Gly Met Leu Gly Leu 
                325                 330                 335     

Gly Leu Thr Ala Met Leu Ala Ser Phe Met Ser Gly Met Ala Gly Asn 
            340                 345                 350         

Val Thr Ala Phe Thr Thr Val Trp Thr Tyr Asp Ile Tyr Gln Ala Tyr 
        355                 360                 365             

Ile Lys Lys Asp Ala Pro Asp Lys His Tyr Val Asn Met Gly Arg Trp 
    370                 375                 380                 

Ala Val Val Val Gly Val Ile Ile Ser Ile Gly Thr Ala Tyr Phe Ala 
385                 390                 395                 400 

Ala Gly Phe Pro Ser Val Met Asp Tyr Met Gln Thr Leu Phe Ser Phe 
                405                 410                 415     

Phe Asn Ala Pro Leu Phe Ala Thr Phe Leu Leu Gly Met Phe Trp Lys 
            420                 425                 430         

Lys Ala Thr Pro Trp Gly Gly Phe Trp Gly Leu Leu Ala Gly Ile Ala 
        435                 440                 445             

Gly Ala Phe Ala Met Tyr Phe Phe Leu Pro Ala His Met Phe Ser Ser 
    450                 455                 460                 

Pro Asp Ala Gly Asn Phe Trp Arg Ala Trp Trp Ala Trp Val Ile Thr 
465                 470                 475                 480 

Val Val Val Thr Val Leu Val Ser Leu Val Thr Gln Gly Lys Arg Pro 
                485                 490                 495     

Glu Glu Leu Glu Gly Leu Val Tyr Gly Leu Ser Lys Arg Pro Asp Tyr 
            500                 505                 510         

Ser Gly Tyr Pro Trp Tyr Lys Arg Pro Gly Tyr Leu Ala Ala Ile Val 
        515                 520                 525             

Phe Val Ile Leu Val Gly Leu Asn Ile Ala Phe Trp 
    530                 535                 540 

<210>   113
<211>   540
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   113
Met His Arg Val His Ala Leu Phe His Ala Asn Ala Val Asp Tyr Ile 
                5                   10                  15      

Ile Ile Leu Val Tyr Phe Ala Phe Val Leu Gly Val Gly Phe Val Leu 
            20                  25                  30          

Arg Asn Arg Val Arg Thr Gly Glu Asp Phe Phe Leu Ser Gly Arg Ser 
        35                  40                  45              

Ile Pro Ala Trp Ile Thr Gly Leu Ala Phe Leu Ser Ala Asn Leu Gly 
    50                  55                  60                  

Ala Leu Glu Ile Leu Gly Met Thr Ala Ser Gly Ala Glu Tyr Gly Met 
65                  70                  75                  80  

Leu Thr Thr His Phe Tyr Trp Ile Gly Ala Ile Pro Ala Met Leu Phe 
                85                  90                  95      

Leu Gly Leu Tyr Met Met Pro Phe Tyr Tyr Val Ser Lys Val Arg Ser 
            100                 105                 110         

Val Pro Glu Phe Leu Lys Leu Arg Tyr Asn Glu Ala Thr Arg Ala Leu 
        115                 120                 125             

Asn Ala Ile Ala Phe Ala Val Met Thr Val Leu Thr Ser Gly Ile Ser 
    130                 135                 140                 

Leu Tyr Ser Met Ala Leu Ile Phe Gln Ile Leu Ile Gly Trp Ser Phe 
145                 150                 155                 160 

Asp Thr Ser Ile Leu Val Ser Ala Leu Val Val Leu Ile Tyr Val Ala 
                165                 170                 175     

Leu Gly Gly Leu Thr Ser Ser Ile Phe Asn Glu Val Val Gln Phe Phe 
            180                 185                 190         

Leu Ile Trp Ala Gly Leu Leu Pro Ile Pro Leu Ile Gly Leu His Asn 
        195                 200                 205             

Leu Gly Gly Trp Gln Gly Met Met Ser Arg Leu Pro Ala Gly Phe Gly 
    210                 215                 220                 

His Leu Trp Ala Asn Leu Gly Ser Pro Ser His Asn Pro Met Gly Ile 
225                 230                 235                 240 

Gly Trp Leu Gly Val Val Leu Gly Leu Gly Phe Val Leu Ser Phe Gly 
                245                 250                 255     

Tyr Trp Thr Thr Asp Phe Leu Val Val Gln Arg Thr Leu Ala Ala Lys 
            260                 265                 270         

Asp Leu Arg Ala Ala Gln Leu Thr Pro Ile Tyr Ala Ala Phe Phe Lys 
        275                 280                 285             

Met Ile Val Pro Ile Leu Val Ile Ile Pro Gly Leu Ile Ala Leu Ala 
    290                 295                 300                 

Ile Phe Pro Lys Ile Gly His Ser Pro Asn Met Ser Tyr Asn Leu Ala 
305                 310                 315                 320 

Leu Pro Leu Leu Ile Ala Lys Tyr Tyr Pro Pro Gly Met Leu Gly Leu 
                325                 330                 335     

Gly Leu Thr Ala Met Leu Ala Ser Phe Met Ser Gly Met Ala Gly Asn 
            340                 345                 350         

Val Thr Ala Phe Thr Thr Val Trp Thr Tyr Asp Ile Tyr Gln Ala Tyr 
        355                 360                 365             

Ile Lys Lys Asp Ala Pro Asp Lys His Tyr Val Asn Met Gly Arg Trp 
    370                 375                 380                 

Ala Val Val Val Gly Val Ile Ile Ser Ile Gly Thr Ala Tyr Phe Ala 
385                 390                 395                 400 

Ala Gly Phe Pro Ser Val Met Asp Tyr Met Gln Thr Leu Phe Ser Phe 
                405                 410                 415     

Phe Asn Ala Pro Leu Phe Ala Thr Phe Leu Leu Gly Met Phe Trp Lys 
            420                 425                 430         

Lys Ala Thr Pro Trp Gly Gly Phe Trp Gly Leu Leu Ala Gly Ile Ala 
        435                 440                 445             

Gly Ala Phe Ala Met Tyr Phe Phe Leu Pro Ala His Met Phe Ser Ser 
    450                 455                 460                 

Pro Asp Ala Gly Asn Phe Trp Arg Ala Trp Trp Ala Trp Val Ile Thr 
465                 470                 475                 480 

Val Val Val Thr Val Leu Val Ser Leu Val Thr Gln Gly Lys Arg Pro 
                485                 490                 495     

Glu Glu Leu Glu Gly Leu Val Tyr Gly Leu Ser Lys Lys Pro Asp Tyr 
            500                 505                 510         

Ser Gly Tyr Pro Trp Tyr Lys Arg Pro Gly Tyr Leu Ala Ala Ile Val 
        515                 520                 525             

Phe Val Ile Leu Val Gly Leu Asn Ile Ala Phe Trp 
    530                 535                 540 

<210>   114
<211>   540
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   114
Met His Arg Val His Ala Leu Phe His Ala Asn Ala Val Asp Tyr Ile 
                5                   10                  15      

Ile Ile Leu Val Tyr Phe Ala Phe Val Leu Gly Val Gly Phe Val Leu 
            20                  25                  30          

Arg Asn Arg Val Arg Thr Gly Glu Asp Phe Phe Leu Ser Gly Arg Ser 
        35                  40                  45              

Ile Pro Ala Trp Ile Thr Gly Leu Ala Phe Leu Ser Ala Asn Leu Gly 
    50                  55                  60                  

Ala Leu Glu Ile Leu Gly Met Thr Ala Ser Gly Ala Glu Tyr Gly Met 
65                  70                  75                  80  

Leu Thr Thr His Phe Tyr Trp Ile Gly Ala Ile Pro Ala Met Leu Phe 
                85                  90                  95      

Leu Gly Leu Tyr Met Met Pro Phe Tyr Tyr Val Ser Lys Val Arg Ser 
            100                 105                 110         

Val Pro Glu Phe Leu Lys Leu Arg Tyr Asn Glu Ala Thr Arg Ala Leu 
        115                 120                 125             

Asn Ala Ile Ala Phe Ala Val Met Thr Val Leu Thr Ser Gly Ile Ser 
    130                 135                 140                 

Leu Tyr Ser Met Ala Leu Ile Phe Gln Ile Leu Ile Gly Trp Ser Phe 
145                 150                 155                 160 

Asp Thr Ser Ile Leu Val Ser Ala Leu Val Val Leu Ile Tyr Val Ala 
                165                 170                 175     

Leu Gly Gly Leu Thr Ser Ser Ile Phe Asn Glu Val Val Gln Phe Phe 
            180                 185                 190         

Leu Ile Trp Ala Gly Leu Leu Pro Ile Pro Leu Ile Gly Leu His Asn 
        195                 200                 205             

Leu Gly Gly Trp Gln Gly Met Met Ser Arg Leu Pro Ala Gly Phe Gly 
    210                 215                 220                 

His Leu Trp Ala Asn Leu Gly Ser Pro Ser His Asn Pro Met Gly Ile 
225                 230                 235                 240 

Gly Trp Leu Gly Val Val Leu Gly Leu Gly Phe Val Leu Ser Phe Gly 
                245                 250                 255     

Tyr Trp Thr Thr Asp Phe Leu Val Val Gln Arg Thr Leu Ala Ala Lys 
            260                 265                 270         

Asp Leu Arg Ala Ala Gln Leu Thr Pro Ile Tyr Ala Ala Phe Phe Lys 
        275                 280                 285             

Met Ile Val Pro Ile Leu Val Ile Ile Pro Gly Leu Ile Ala Leu Ala 
    290                 295                 300                 

Ile Phe Pro Lys Ile Gly His Ser Pro Asn Met Ser Tyr Asn Leu Ala 
305                 310                 315                 320 

Leu Pro Leu Leu Ile Ala Lys Tyr Tyr Pro Pro Gly Met Leu Gly Leu 
                325                 330                 335     

Gly Leu Thr Ala Met Leu Ala Ser Phe Met Ser Gly Met Ala Gly Asn 
            340                 345                 350         

Val Thr Ala Phe Thr Thr Val Trp Thr Tyr Asp Ile Tyr Gln Ala Tyr 
        355                 360                 365             

Ile Lys Lys Asp Ala Pro Asp Lys His Tyr Val Asn Met Gly Arg Trp 
    370                 375                 380                 

Ala Val Val Val Gly Val Ile Ile Ser Ile Gly Thr Ala Tyr Phe Ala 
385                 390                 395                 400 

Ala Gly Phe Pro Ser Val Met Asp Tyr Met Gln Thr Leu Phe Ser Phe 
                405                 410                 415     

Phe Asn Ala Pro Leu Phe Ala Thr Phe Leu Leu Gly Met Phe Trp Lys 
            420                 425                 430         

Lys Ala Thr Pro Trp Gly Gly Phe Trp Gly Leu Leu Ala Gly Ile Ala 
        435                 440                 445             

Gly Ala Phe Ala Met Tyr Phe Phe Leu Pro Ala His Met Phe Ser Ser 
    450                 455                 460                 

Pro Asp Ala Gly Asn Phe Trp Arg Ala Trp Trp Ala Trp Ile Ile Thr 
465                 470                 475                 480 

Val Val Val Thr Val Leu Val Ser Leu Val Thr Gln Gly Lys Arg Pro 
                485                 490                 495     

Glu Glu Leu Glu Gly Leu Val Tyr Gly Leu Ser Lys Arg Pro Asp Tyr 
            500                 505                 510         

Ser Gly Tyr Pro Trp Tyr Lys Arg Pro Gly Tyr Leu Ala Ala Ile Val 
        515                 520                 525             

Phe Val Ile Leu Val Gly Leu Asn Ile Ala Phe Trp 
    530                 535                 540 

<210>   115
<211>   1623
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   115
gtgcatcggg tgcacgcgct atttcatgcg aacgccgtgg actacatcat catcctggtc       60

tacttcgctt tcgtcctcgg cgtcggattc gtccttcgta accgcgttcg cactggagag      120

gatttctttt tgtccggccg atccatcccg gcctggatca cgggcttggc gtttctatcc      180

gccaacctcg gggcgctcga gattctcggc atgaccgcga gcggcgccga atacggcatg      240

ctcacgactc acttttactg gatcggtgcg ttaccggcca tgttgtttct cggcctgtac      300

atgatgccgt tttactatgt gtcgaaggtg cgctcggtgc cggagttctt gaaactgcgg      360

tacaacgaag cgacccgcgc gctcaatgcc atcgcgttcg ccgtgatgac cgtcctgacg      420

tcgggcatca gcttgtattc catggcgctg atctttcaga tcttgattgg ttggtcgttt      480

gacaccagca ttctcgtgtc tgcgctcgtg gttttgatct acgttgcgct cggaggtctg      540

acctcgtcga tctttaacga ggtcgtgcag ttcttcttga tttgggctgg tttgctgccc      600

atcccgctca tcggcctgca caatctgggc ggatggcagg gcatgatgtc ccggctgccc      660

gcggggttcg gacatctttg ggcgaacctg ggttccccgt ctcacaaccc gatgggaatt      720

ggctggcttg gcgtggtgct cgggctcggt tttgtgctct cgttcgggta ctggacgacg      780

gacttcttgg tcgttcagcg caccctcgcg gcgaaggatc tgcgcgcggc ccaattgacg      840

ccgatttacg cagcgttctt taagatgatt gttccgattc tggtgatcat cccggggctg      900

attgcgctcg ccatctttcc gaagatcggc cattcgccga acatgagcta caacctggcg      960

ctgcccctgc tcatcgccaa atactatccg cctggcatgc tcgggcttgg actgacggcc     1020

atgctcgcga gcttcatgag cggtatggcg ggcaatgtca ccgcgtttac gacggtttgg     1080

acgtatgata tctatcaggc gtacatcaag aaggacgcac cggacaagca ctatgtgaac     1140

atggggcgct gggcggtcgt ggtcggcgtc atcatcagca tcggcaccgc ctacttcgcg     1200

gccggtttcc cgagcgtcat ggattacatg cagacgctgt tctcgttctt caacgcgccg     1260

ctgttcgcca cgttcttgtt ggggatgttc tggaaaaagg ccacgccttg gggcggtttc     1320

tggggcctgc tcgcgggtat cgccggcgcg ttcgccatgt acttcttcct gcccgcgcat     1380

atgttctcga gcccggatgc aggtaacttc tggcgcgcat ggtgggcctg ggtgatcacg     1440

gtcgtcgtga ccgtcttggt aagccttgtg acgcagggca agcggcccga agagctggaa     1500

ggcctcgtgt acggcctcag caagcggccc gactacagcg gttatccgtg gtacaagcgc     1560

ccgggttacc tggcggccat cgtgttcgtg atcctggtgg gcctgaatat cgcgttctgg     1620

tga                                                                   1623


<210>   116
<211>   1623
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   116
gtgcatcggg tgcacgcgat ttttcatgcg aacgccgtgg actacatcat catcctggtc       60

tacttcgctt tcgtcctcgg cgtcggattc gtccttcgta accgcgttcg cactggagag      120

gatttctttt tgtccggccg atccatcccg gcctggatca cgggcttggc gtttctatcc      180

gccaacctcg gggcgctcga gattctcggc atgaccgcga gcggcgccga atacggcatg      240

ctcacgactc acttttactg gatcggtgcg atcccggcca tgttgtttct cggcctgtac      300

atgatgccgt tttactatgt gtcgaaggtg cgctcggtgc cggagttctt gaaactgcgg      360

tacaacgaag cgacccgcgc gctcaatgcc atcgcgttcg ccgtgatgac cgtcctgacg      420

tcgggcatca gcttgtattc catggcgctg atctttcaga tcttgattgg ttggtcgttt      480

gacaccagca ttctcgtgtc tgcgctcgtg gttttgatct acgttgcgct cggaggtctg      540

acctcgtcga tctttaacga ggtcgtgcag ttcttcttga tttgggctgg tttgctgccc      600

atcccgctca tcggcctgca caatctgggc ggatggcagg gcatgatgtc ccggctgccc      660

gcggggttcg gacatctttg ggcgaacctg ggttccccgt ctcacaaccc gatgggaatt      720

ggctggcttg gcgtggtgct cgggctcggt tttgtgctct cgttcgggta ctggacgacg      780

gacttcttgg tcgttcagcg caccctcgcg gcgaaggatc tgcgcgcggc ccaattgacg      840

ccgatttacg cagcgttctt taagatgatt gttccgattc tggtgatcat cccggggctg      900

attgcgctcg ccatctttcc gaagatcggc cattcgccga acatgagcta caacctggcg      960

ctgcccctgc tcatcgccaa atactatccg cctggcatgc tcgggcttgg actgacggcc     1020

atgctcgcga gcttcatgag cggtatggcg ggcaatgtca ccgcgtttac gacggtttgg     1080

acgtatgata tctatcaggc gtacatcaag aaggacgcac cggacaagca ctatgtgaac     1140

atggggcgct gggcggtcgt ggtcggcgtc atcatcagca tcggcaccgc ctacttcgcg     1200

gccggtttcc cgagcgtcat ggattacatg cagacgctgt tctcgttctt caacgcgccg     1260

ctgttcgcca cgttcttgtt ggggatgttc tggaaaaagg ccacgccttg gggcggtttc     1320

tggggcctgc tcgcgggtat cgccggcgcg ttcgccatgt acttcttcct gcccgcgcat     1380

atgttctcga gcccggatgc aggtaacttc tggcgcgcat ggtgggcctg ggtgatcacg     1440

gtcgtcgtga ccgtcttggt aagccttgtg acgcagggca agcggcccga agagctggaa     1500

ggcctcgtgt acggcctcag caagcggccc gactacagcg gttatccgtg gtacaagcgc     1560

ccgggttacc tggcggccat cgtgttcgtg atcctggtgg gcctgaatat cgcgttctgg     1620

tga                                                                   1623


<210>   117
<211>   1623
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   117
gtgcatcggg tgcacgcgct atttcatgcg aacgccgtgg actacatcat catcctggtc       60

tacttcgctt tcgtcctcgg cgtcggattc gtccttcgta accgcgttcg cactggagag      120

gatttctttt tgtccggccg atccatcccg gcctggatca cgggcttggc gtttctatcc      180

gccaacctcg gggcgctcga gattctcggc atgaccgcga gcggcgccga atacggcatg      240

ctcacgactc acttttactg gatcggtgcg atcccggcca tgttgtttct cggcctgtac      300

atgatgccgt tttactatgt gtcgaaggtg cgctcggtgc cggagttctt gaaactgcgg      360

taccaagaag cgacccgcgc gctcaatgcc atcgcgttcg ccgtgatgac cgtcctgacg      420

tcgggcatca gcttgtattc catggcgctg atctttcaga tcttgattgg ttggtcgttt      480

gacaccagca ttctcgtgtc tgcgctcgtg gttttgatct acgttgcgct cggaggtctg      540

acctcgtcga tctttaacga ggtcgtgcag ttcttcttga tttgggctgg tttgctgccc      600

atcccgctca tcggcctgca caatctgggc ggatggcagg gcatgatgtc ccggctgccc      660

gcggggttcg gacatctttg ggcgaacctg ggttccccgt ctcacaaccc gatgggaatt      720

ggctggcttg gcgtggtgct cgggctcggt tttgtgctct cgttcgggta ctggacgacg      780

gacttcttgg tcgttcagcg caccctcgcg gcgaaggatc tgcgcgcggc ccaattgacg      840

ccgatttacg cagcgttctt taagatgatt gttccgattc tggtgatcat cccggggctg      900

attgcgctcg ccatctttcc gaagatcggc cattcgccga acatgagcta caacctggcg      960

ctgcccctgc tcatcgccaa atactatccg cctggcatgc tcgggcttgg actgacggcc     1020

atgctcgcga gcttcatgag cggtatggcg ggcaatgtca ccgcgtttac gacggtttgg     1080

acgtatgata tctatcaggc gtacatcaag aaggacgcac cggacaagca ctatgtgaac     1140

atggggcgct gggcggtcgt ggtcggcgtc atcatcagca tcggcaccgc ctacttcgcg     1200

gccggtttcc cgagcgtcat ggattacatg cagacgctgt tctcgttctt caacgcgccg     1260

ctgttcgcca cgttcttgtt ggggatgttc tggaaaaagg ccacgccttg gggcggtttc     1320

tggggcctgc tcgcgggtat cgccggcgcg ttcgccatgt acttcttcct gcccgcgcat     1380

atgttctcga gcccggatgc aggtaacttc tggcgcgcat ggtgggcctg ggtgatcacg     1440

gtcgtcgtga ccgtcttggt aagccttgtg acgcagggca agcggcccga agagctggaa     1500

ggcctcgtgt acggcctcag caagcggccc gactacagcg gttatccgtg gtacaagcgc     1560

ccgggttacc tggcggccat cgtgttcgtg atcctggtgg gcctgaatat cgcgttctgg     1620

tga                                                                   1623


<210>   118
<211>   1623
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   118
gtgcatcggg tgcacgcgct atttcatgcg aacgccgtgg actacatcat catcctggtc       60

tacttcgctt tcgtcctcgg cgtcggattc gtccttcgta accgcgttcg cactggagag      120

gatttctttt tgtccggccg atccatcccg gcctggatca cgggcttggc gtttctatcc      180

gccaacctcg gggcgctcga gattctcggc atgaccgcga gcggcgccga atacggcatg      240

ctcacgactc acttttactg gatcggtgcg atcccggcca tgttgtttct cggcctgtac      300

atgatgccgt tttactatgt gtcgaaggtg cgctcggtgc cggagttctt gaaactgcgg      360

tacaacgaag cgacccgcgc gctcaatgcc atcgcgttcg ccgtgatgac cgtcctgacg      420

tcgggcatca gcttgtattc catggcgctg atctttcaga tcttgattgg ttggtcgttt      480

gacaccagca ttctcgtgtc tgcgctcgtg gttttgatct acgttgcgct cggaggtctg      540

acctcgtcga tctttaacga ggtcgtgcag ttcttcttga tttgggctgg tttgctgccc      600

atcccgctca tcggcctgca caatctgggc ggatggcagg gcatgatgtc ccggctgccc      660

gcggggttcg gacatctttg ggcgaacctg ggttccccgt ctcacaaccc gatgggaatt      720

ggctggcttg gcgtggtgct cgggctcggt tttgtgctct cgttcgggta ctggacgacg      780

gacttcttgg tcgttcagcg caccctcgcg gcgaaggatc tgcgcgcggc ccaattgacg      840

ccgatttacg cagcgttctt taagatgatt gttccgattc tggtgatcat cccggggctg      900

attgcgctcg ccatctttcc gaagatcggc cattcgccga acatgagcta caacctggcg      960

ctgcccctgc tcatcgccaa atactatccg cctggcatgc tcgggcttgg actgacggcc     1020

atgctcgcga gcttcatgag cggtatggcg ggcaatgtca ccgcgtttac gacggtttgg     1080

acgtatgata tctatcaggc gtacatcaag aaggacgcac cggacaagca ctatgtgaac     1140

atggggcgct gggcggtcgt ggtcggcgtc atcatcagca tcggcaccgc ctacttcgcg     1200

gccggtttcc cgagcgtcat ggattacatg cagacgctgt tctcgttctt caacgcgccg     1260

ctgttcgcca cgttcttgtt ggggatgttc tggaaaaagg ccacgccttg gggcggtttc     1320

tggggcctgc tcgcgggtat cgccggcgcg ttcgccatgt acttcttcct gcccgcgcat     1380

atgttctcga gcccggatgc aggtaacttc tggcgcgcat ggtgggcctg ggtgatcacg     1440

gtcgtcgtga ccgtcttggt aagccttgtg acgcagggca agcggcccga agagctggaa     1500

ggcctcgtgt acggcctcag caagaaaccc gactacagcg gttatccgtg gtacaagcgc     1560

ccgggttacc tggcggccat cgtgttcgtg atcctggtgg gcctgaatat cgcgttctgg     1620

tga                                                                   1623


<210>   119
<211>   1623
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   119
gtgcatcggg tgcacgcgct atttcatgcg aacgccgtgg actacatcat catcctggtc       60

tacttcgctt tcgtcctcgg cgtcggattc gtccttcgta accgcgttcg cactggagag      120

gatttctttt tgtccggccg atccatcccg gcctggatca cgggcttggc gtttctatcc      180

gccaacctcg gggcgctcga gattctcggc atgaccgcga gcggcgccga atacggcatg      240

ctcacgactc acttttactg gatcggtgcg atcccggcca tgttgtttct cggcctgtac      300

atgatgccgt tttactatgt gtcgaaggtg cgctcggtgc cggagttctt gaaactgcgg      360

tacaacgaag cgacccgcgc gctcaatgcc atcgcgttcg ccgtgatgac cgtcctgacg      420

tcgggcatca gcttgtattc catggcgctg atctttcaga tcttgattgg ttggtcgttt      480

gacaccagca ttctcgtgtc tgcgctcgtg gttttgatct acgttgcgct cggaggtctg      540

acctcgtcga tctttaacga ggtcgtgcag ttcttcttga tttgggctgg tttgctgccc      600

atcccgctca tcggcctgca caatctgggc ggatggcagg gcatgatgtc ccggctgccc      660

gcggggttcg gacatctttg ggcgaacctg ggttccccgt ctcacaaccc gatgggaatt      720

ggctggcttg gcgtggtgct cgggctcggt tttgtgctct cgttcgggta ctggacgacg      780

gacttcttgg tcgttcagcg caccctcgcg gcgaaggatc tgcgcgcggc ccaattgacg      840

ccgatttacg cagcgttctt taagatgatt gttccgattc tggtgatcat cccggggctg      900

attgcgctcg ccatctttcc gaagatcggc cattcgccga acatgagcta caacctggcg      960

ctgcccctgc tcatcgccaa atactatccg cctggcatgc tcgggcttgg actgacggcc     1020

atgctcgcga gcttcatgag cggtatggcg ggcaatgtca ccgcgtttac gacggtttgg     1080

acgtatgata tctatcaggc gtacatcaag aaggacgcac cggacaagca ctatgtgaac     1140

atggggcgct gggcggtcgt ggtcggcgtc atcatcagca tcggcaccgc ctacttcgcg     1200

gccggtttcc cgagcgtcat ggattacatg cagacgctgt tctcgttctt caacgcgccg     1260

ctgttcgcca cgttcttgtt ggggatgttc tggaaaaagg ccacgccttg gggcggtttc     1320

tggggcctgc tcgcgggtat cgccggcgcg ttcgccatgt acttcttcct gcccgcgcat     1380

atgttctcga gcccggatgc aggtaacttc tggcgcgcat ggtgggcctg gattatcacg     1440

gtcgtcgtga ccgtcttggt aagccttgtg acgcagggca agcggcccga agagctggaa     1500

ggcctcgtgt acggcctcag caagcggccc gactacagcg gttatccgtg gtacaagcgc     1560

ccgggttacc tggcggccat cgtgttcgtg atcctggtgg gcctgaatat cgcgttctgg     1620

tga                                                                   1623


<210>   120
<211>   384
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   120
Met Ala Arg Val Leu Leu Glu His Ile Tyr Lys Thr Tyr Pro Gly Gln 
                5                   10                  15      

Thr Glu Pro Thr Val Lys Asp Phe Asn Leu Asp Ile Gln Asp Lys Glu 
            20                  25                  30          

Phe Thr Val Phe Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu 
        35                  40                  45              

Arg Met Ile Ala Gly Leu Glu Asp Ile Thr Glu Gly Asn Leu Tyr Ile 
    50                  55                  60                  

Gly Asp Arg Arg Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Gln 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Lys Ala Glu Ile 
            100                 105                 110         

Asp Arg Arg Val Gln Glu Ala Ala Lys Ile Leu Asp Ile Ala His Leu 
        115                 120                 125             

Leu Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Leu Gly Arg Ala Ile Val Arg Glu Pro Gln Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Ala 
                165                 170                 175     

Glu Ile Arg Lys Leu His Gln Arg Leu Gln Thr Thr Val Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Met Gly Asp Arg Ile Val Val 
        195                 200                 205             

Met Arg Asp Gly Val Ile Gln Gln Ala Asp Thr Pro Gln Val Val Tyr 
    210                 215                 220                 

Ser Gln Pro Lys Asn Met Phe Val Ala Gly Phe Ile Gly Ser Pro Ala 
225                 230                 235                 240 

Met Asn Phe Ile Arg Gly Glu Ile Val Gln Asp Gly Asp Ala Phe Tyr 
                245                 250                 255     

Phe Arg Ala Pro Ser Ile Ser Leu Arg Leu Pro Glu Gly Arg Tyr Gly 
            260                 265                 270         

Val Leu Lys Ala Ser Gly Ala Ile Gly Lys Pro Val Val Leu Gly Val 
        275                 280                 285             

Arg Pro Glu Asp Leu His Asp Glu Glu Val Phe Met Thr Thr Tyr Pro 
    290                 295                 300                 

Asp Ser Val Leu Gln Met Gln Val Glu Val Val Glu His Met Gly Ser 
305                 310                 315                 320 

Glu Val Tyr Leu His Thr Ser Ile Gly Pro Asn Thr Ile Val Ala Arg 
                325                 330                 335     

Val Asn Pro Arg His Val Tyr His Val Gly Ser Ser Val Lys Leu Ala 
            340                 345                 350         

Ile Asp Leu Asn Lys Ile His Ile Phe Asp Ala Glu Thr Glu Glu Ser 
        355                 360                 365             

Ile Gly Phe Ala Ala Gly Pro Ala Gly Glu Arg Gln Glu Ala Leu Val 
    370                 375                 380                 

<210>   121
<211>   1155
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   121
gtggctcgcg tgttgctcga gcacatttac aagacctacc ccggccagac ggagccgacg       60

gtgaaggact tcaacctcga cattcaggac aaggaattca ccgtgttcgt cggcccctcc      120

ggctgcggca agacgacgac gcttcgcatg atcgctggac tcgaggacat cacggagggc      180

aacctgtata tcggcgatcg ccgcgtgaac gacgtgccgc cgaaggatcg ggacattgcg      240

atggtgttcc aaaactacgc gctctatccc catatgacgg tgtatcagaa catggcgttc      300

ggcctgaagc tgcgcaaggt gccgaaggcc gagatcgacc ggcgggtgca ggaggcggcg      360

aagatcctcg acatcgcgca cctgctcgac cggaagccga aggcgctctc cggcggtcag      420

cgccagcgcg tggcgttggg tcgcgccatt gtgcgcgagc cgcaggtgtt cctgatggat      480

gagccgctgt cgaacctgga cgcgaagctg cgcgtgcaga tgcgcgcgga gatccgcaag      540

ctccatcagc gcttgcaaac gaccgtcatt tacgttacac atgatcagac ggaagccatg      600

acgatgggcg atcgcatcgt ggtcatgcgc gacggcgtca tccagcaggc ggatacgccg      660

caggtcgtgt actcccagcc gaagaacatg tttgtcgccg gcttcattgg gtctcctgcc      720

atgaacttta ttcgcggcga gatcgtgcag gacggcgatg cgttctactt ccgcgcgcct      780

tccatttcgc tgcgcctgcc ggagggccgc tacggcgtgc tgaaggcgtc gggggccatt      840

gggaagccgg tcgtgctcgg cgtgcggccg gaagacctgc acgatgagga agtgttcatg      900

acgacgtatc ccgactccgt gctgcagatg caggtggaag tcgtggaaca catgggctcg      960

gaggtctatc tgcacacgag tatcgggccg aacacgatcg tcgcgcgcgt gaacccgcgc     1020

cacgtctacc acgtcggaag ctcggtcaag ctcgcgattg acttgaacaa gatccacatc     1080

ttcgacgcgg agacggagga gtccatcggc ttcgccgcag gtcctgcggg tgaacgtcaa     1140

gaagctttgg tgtga                                                      1155


<210>   122
<211>   384
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   122
Met Ala Arg Val Leu Leu Glu His Ile Tyr Lys Thr Tyr Pro Gly Gln 
                5                   10                  15      

Thr Glu Pro Thr Val Lys Asp Phe Asn Leu Asp Ile Gln Asp Lys Glu 
            20                  25                  30          

Phe Thr Val Phe Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu 
        35                  40                  45              

Arg Met Ile Ala Gly Leu Glu Asp Ile Thr Glu Gly Asn Leu Tyr Ile 
    50                  55                  60                  

Gly Asp Arg Arg Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Gln 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Lys Ala Glu Ile 
            100                 105                 110         

Asp Arg Arg Val Gln Glu Ala Ala Lys Ile Leu Asp Ile Ala His Leu 
        115                 120                 125             

Leu Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Leu Gly Arg Ala Ile Val Arg Glu Pro Gln Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Ala 
                165                 170                 175     

Glu Ile Arg Lys Leu His Gln Arg Leu Gln Thr Thr Val Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Met Gly Asp Arg Ile Val Val 
        195                 200                 205             

Met Arg Asp Gly Val Ile Gln Gln Ala Asp Thr Pro Gln Val Val Tyr 
    210                 215                 220                 

Ser Gln Pro Lys Asn Met Phe Val Ala Gly Phe Ile Gly Ser Pro Ala 
225                 230                 235                 240 

Met Asn Phe Ile Arg Gly Glu Ile Val Gln Asp Gly Asp Ala Phe Tyr 
                245                 250                 255     

Phe Arg Ala Pro Ser Ile Ser Leu Arg Leu Pro Glu Gly Arg Tyr Gly 
            260                 265                 270         

Val Leu Lys Ala Ser Gly Ala Ile Gly Lys Pro Val Val Leu Gly Val 
        275                 280                 285             

Arg Pro Glu Asp Leu His Asp Glu Glu Val Phe Met Thr Thr Tyr Pro 
    290                 295                 300                 

Asp Ser Val Leu Gln Met Gln Val Glu Val Val Glu His Met Gly Ser 
305                 310                 315                 320 

Glu Val Tyr Leu His Thr Ser Ile Gly Pro Asn Thr Ile Val Ala Arg 
                325                 330                 335     

Val Asn Pro Arg His Val Tyr His Val Gly Ser Ser Val Lys Leu Ala 
            340                 345                 350         

Ile Asp Leu Asn Lys Ile His Ile Phe Asp Ala Glu Thr Glu Glu Ser 
        355                 360                 365             

Ile Gly Phe Ala Ala Gly Pro Ala Gly Glu Arg Gln Glu Ala Leu Val 
    370                 375                 380                 

<210>   123
<211>   370
<212>   PRT
<213>   Paenibacillus larvae subsp. larvae BRL-230010

<400>   123
Met Ala Gly Val Arg Leu Asn His Ile Val Lys Lys Tyr Pro Gly Asn 
                5                   10                  15      

Asp Glu Ala Thr Val Lys Asp Phe His Leu Glu Ile Lys Asp Lys Glu 
            20                  25                  30          

Phe Leu Val Leu Val Gly Ala Ser Gly Cys Gly Lys Ser Thr Thr Leu 
        35                  40                  45              

Arg Met Val Ala Gly Leu Glu Glu Ile Thr Glu Gly Glu Leu Tyr Ile 
    50                  55                  60                  

Gly Asp Arg Leu Val Asn Asp Val Ala Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Ser Tyr Ala Leu Tyr Pro His Met Asn Val Tyr Gln 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Phe Lys Lys Ala Asp Ile 
            100                 105                 110         

Asp Thr Arg Val Arg Glu Ala Ala Lys Leu Leu Glu Ile Glu His Leu 
        115                 120                 125             

Leu Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Leu Gly Arg Ala Ile Val Arg Glu Pro Gln Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Ala 
                165                 170                 175     

Val Ile Ser Lys Leu Val Lys Arg Leu Glu Thr Thr Cys Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Met Gly Asp Arg Ile Val Val 
        195                 200                 205             

Met Asp Lys Gly Val Ile Gln Gln Ala Ala Ser Pro Lys Glu Ile Tyr 
    210                 215                 220                 

Asn Phe Pro Val Asn Met Phe Val Ala Gly Phe Ile Gly Ser Pro Ser 
225                 230                 235                 240 

Met Asn Phe Val Asp Gly Ala Ile Ser Glu Glu Asn Asp Glu Leu Leu 
                245                 250                 255     

Phe Lys Ala Pro Gly Val Asn Ile Val Ile Pro Glu Gly Lys Ala Lys 
            260                 265                 270         

Leu Leu Arg Glu Lys Gly Tyr Thr Asn Lys Glu Val Val Leu Gly Ile 
        275                 280                 285             

Arg Pro Glu Asp Leu His Glu Glu Pro Val Phe Leu Glu Ala Ser Pro 
    290                 295                 300                 

Asn Ser Ile Val Ser Ala Asn Ile Glu Val Ala Glu Asn Leu Gly His 
305                 310                 315                 320 

Glu Met Asn Leu Tyr Ile Asn Gly Ile Gly Thr Ser Ser Val Ile Ala 
                325                 330                 335     

Arg Val Asp Gly Arg Ser Gly Leu Lys Glu Gly Ser Thr Val Lys Leu 
            340                 345                 350         

Ala Leu Asp Met Asn Lys Val His Phe Phe Asp Lys Glu Thr Thr Glu 
        355                 360                 365             

Ser Ile 
    370 

<210>   124
<211>   368
<212>   PRT
<213>   Caldicellulosiruptor saccharolyticus DSM 8903

<400>   124
Met Ala Ser Val Arg Leu Lys Gly Val Tyr Lys Arg Tyr Pro Gly Gly 
                5                   10                  15      

Val Thr Ala Val Ser Asp Phe Asn Leu Asp Ile Glu Asp Lys Glu Phe 
            20                  25                  30          

Ile Val Leu Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu Arg 
        35                  40                  45              

Met Ile Ala Gly Leu Glu Glu Val Thr Glu Gly Glu Ile Tyr Ile Gly 
    50                  55                  60                  

Asp Lys Leu Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala Met 
65                  70                  75                  80  

Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Phe Glu Asn 
                85                  90                  95      

Met Ala Phe Gly Leu Lys Leu Arg Lys Phe Pro Lys Asp Glu Ile Lys 
            100                 105                 110         

Arg Arg Val His Glu Ala Ala Lys Ile Leu Gly Ile Glu His Leu Leu 
        115                 120                 125             

Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val Ala 
    130                 135                 140                 

Leu Gly Arg Ala Ile Val Arg Glu Pro Lys Val Phe Leu Met Asp Glu 
145                 150                 155                 160 

Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Thr Glu 
                165                 170                 175     

Leu Ser Lys Leu His Lys Arg Leu Gly Thr Thr Phe Ile Tyr Val Thr 
            180                 185                 190         

His Asp Gln Thr Glu Ala Met Thr Met Gly Thr Arg Ile Val Val Met 
        195                 200                 205             

Lys Asp Gly Phe Ile Gln Gln Val Asp Thr Pro Gln Val Leu Tyr Glu 
    210                 215                 220                 

Gln Pro Ala Asn Leu Phe Val Ala Gly Phe Ile Gly Ser Pro Gln Met 
225                 230                 235                 240 

Asn Phe Ile Glu Ser Arg Ile Glu Gln Lys Asp Lys Asn Leu Tyr Val 
                245                 250                 255     

Val Phe Gly Asn Asn Ala Ile Lys Leu Pro Glu Gly Lys Ala Lys Lys 
            260                 265                 270         

Val Glu Glu Leu Gly Tyr Val Gly Lys Glu Val Ile Met Gly Ile Arg 
        275                 280                 285             

Pro Glu Asp Leu His Asp Glu Glu Ile Phe Leu Gln Thr Ala Gln Asp 
    290                 295                 300                 

Ala Val Val Asp Ala His Val Asp Val Val Glu Met Leu Gly Ser Glu 
305                 310                 315                 320 

Thr Leu Leu Tyr Val Val Val Asp Gly Leu Asn Leu Ile Ala Arg Val 
                325                 330                 335     

Asp Pro Arg Ser Lys Thr Lys Ala Gly Asp Lys Ile Lys Leu Ala Phe 
            340                 345                 350         

Asp Ala Asn Arg Ile His Leu Phe Asp Lys Glu Thr Glu Lys Ala Ile 
        355                 360                 365             

<210>   125
<211>   368
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   125
Met Ala Glu Val Val Leu Lys His Val Tyr Lys Val Tyr Pro Gly Gly 
                5                   10                  15      

Val Thr Ala Val Lys Asp Phe Asn Leu Glu Ile Ala Asp Lys Glu Phe 
            20                  25                  30          

Ile Val Leu Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu Arg 
        35                  40                  45              

Met Ile Ala Gly Leu Glu Glu Ile Thr Ser Gly Glu Leu Tyr Ile Asp 
    50                  55                  60                  

Gly Lys Leu Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala Met 
65                  70                  75                  80  

Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Asp Asn 
                85                  90                  95      

Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Arg Ala Glu Ile Asp 
            100                 105                 110         

Arg Lys Val Lys Glu Ala Ala Arg Ile Leu Gly Leu Glu Glu Leu Leu 
        115                 120                 125             

Asn Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val Ala 
    130                 135                 140                 

Leu Gly Arg Ala Ile Val Arg Asn Pro Lys Val Phe Leu Met Asp Glu 
145                 150                 155                 160 

Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Thr Glu 
                165                 170                 175     

Leu Lys Lys Leu His Glu Arg Leu Gln Thr Thr Phe Ile Tyr Val Thr 
            180                 185                 190         

His Asp Gln Thr Glu Ala Met Thr Met Gly Thr Arg Ile Val Val Met 
        195                 200                 205             

Lys Asp Gly Val Ile Gln Gln Val Asp Glu Pro Gln Val Ile Tyr Asp 
    210                 215                 220                 

Tyr Pro Asn Asn Leu Phe Val Ala Gly Phe Ile Gly Ser Pro Gln Met 
225                 230                 235                 240 

Asn Phe Ile Asp Ala Arg Leu Glu Asn Arg Asp Gly Lys Val Tyr Ala 
                245                 250                 255     

Thr Phe Lys Gly Tyr Ser Ile Leu Val Pro Glu Gly Ile Leu Lys Arg 
            260                 265                 270         

Leu Lys Asp Pro Ser Tyr Ile Gly Lys Glu Ile Val Leu Gly Ile Arg 
        275                 280                 285             

Pro Glu Asp Leu His Asp Glu Glu Val Phe Leu Glu Ala Tyr Pro Glu 
    290                 295                 300                 

Ala Val Val Glu Ala Lys Val Glu Val Thr Glu Leu Met Gly Ala Glu 
305                 310                 315                 320 

Thr Tyr Leu Tyr Leu Asp Val Asn Gly Val Ser Leu Thr Ala Arg Val 
                325                 330                 335     

Asp Pro Arg Thr Arg Ala Lys Ser Gly Asp Val Ile Lys Ile Gly Phe 
            340                 345                 350         

Asp Val Asn Lys Leu His Met Phe Asp Lys Glu Thr Glu Met Thr Ile 
        355                 360                 365             

<210>   126
<211>   368
<212>   PRT
<213>   Thermoanaerobacter pseudethanolicus ATCC 33223

<400>   126
Met Ala Asp Val Val Leu Lys His Val Tyr Lys Val Tyr Pro Gly Gly 
                5                   10                  15      

Val Thr Ala Val Lys Asp Phe Asn Leu Glu Ile Gln Asp Lys Glu Phe 
            20                  25                  30          

Ile Val Leu Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu Arg 
        35                  40                  45              

Met Ile Ala Gly Leu Glu Glu Ile Ser Ser Gly Glu Leu Tyr Ile Asp 
    50                  55                  60                  

Gly Lys Leu Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala Met 
65                  70                  75                  80  

Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Asp Asn 
                85                  90                  95      

Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Arg Ala Glu Ile Asp 
            100                 105                 110         

Arg Lys Val Lys Glu Ala Ala Arg Ile Leu Gly Leu Glu Glu Tyr Leu 
        115                 120                 125             

Asn Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val Ala 
    130                 135                 140                 

Leu Gly Arg Ala Ile Val Arg Asn Pro Lys Val Phe Leu Met Asp Glu 
145                 150                 155                 160 

Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Thr Glu 
                165                 170                 175     

Leu Ala Lys Leu His Asp Arg Leu Gln Thr Thr Phe Ile Tyr Val Thr 
            180                 185                 190         

His Asp Gln Thr Glu Ala Met Thr Met Gly Thr Arg Ile Val Val Met 
        195                 200                 205             

Lys Asp Gly Val Ile Gln Gln Val Asp Lys Pro Gln Thr Ile Tyr Asp 
    210                 215                 220                 

Tyr Pro Asn Asn Leu Phe Val Ala Gly Phe Ile Gly Ser Pro Gln Met 
225                 230                 235                 240 

Asn Phe Ile Asp Ala Arg Leu Glu Asn Lys Asn Gly Lys Val Tyr Ala 
                245                 250                 255     

Thr Phe Lys Gly Phe Ser Ile Leu Val Pro Glu Gly Ile Leu Lys Arg 
            260                 265                 270         

Leu Lys Asp Pro Ser Tyr Val Gly Lys Glu Ile Val Leu Gly Ile Arg 
        275                 280                 285             

Pro Glu Asp Leu His Asp Glu Glu Val Phe Leu Glu Ala Tyr Pro Glu 
    290                 295                 300                 

Ala Val Val Glu Ala Lys Val Asp Val Thr Glu Leu Met Gly Pro Glu 
305                 310                 315                 320 

Thr Tyr Leu Tyr Leu Asp Val Asn Gly Val Pro Leu Thr Ala Arg Val 
                325                 330                 335     

Asp Pro Arg Thr Arg Ala Lys Ala Gly Asp Val Ile Lys Ile Gly Phe 
            340                 345                 350         

Asp Ile Asn Lys Leu His Met Phe Asp Lys Glu Thr Glu Met Ser Ile 
        355                 360                 365             

<210>   127
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   127
Met Ala Arg Val Leu Leu Asp His Ile Tyr Lys Thr Tyr Pro Gly Gln 
                5                   10                  15      

Thr Glu Pro Thr Val Lys Asp Phe Asn Leu Asp Ile Gln Asp Lys Glu 
            20                  25                  30          

Phe Thr Val Phe Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu 
        35                  40                  45              

Arg Met Ile Ala Gly Leu Glu Asp Ile Thr Glu Gly Asn Leu Tyr Ile 
    50                  55                  60                  

Gly Asp Arg Arg Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Gln 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Lys Ala Glu Ile 
            100                 105                 110         

Asp Arg Arg Val Gln Glu Ala Ala Lys Ile Leu Asp Ile Ala His Leu 
        115                 120                 125             

Leu Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Leu Gly Arg Ala Ile Val Arg Glu Pro Gln Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Ala 
                165                 170                 175     

Glu Ile Arg Lys Leu His Gln Arg Leu Gln Thr Thr Val Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Met Gly Asp Arg Ile Val Val 
        195                 200                 205             

Met Arg Asp Gly Val Ile Gln Gln Ala Asp Thr Pro Gln Val Val Tyr 
    210                 215                 220                 

Ser Gln Pro Lys Asn Met Phe Val Ala Gly Phe Ile Gly Ser Pro Ala 
225                 230                 235                 240 

Met Asn Phe Ile Arg Gly Glu Ile Val Gln Asp Gly Asp Ala Phe Tyr 
                245                 250                 255     

Phe Arg Ala Pro Ser Ile Ser Leu Arg Leu Pro Glu Gly Arg Tyr Gly 
            260                 265                 270         

Val Leu Lys Ala Ser Gly Ala Ile Gly Lys Pro Val Val Leu Gly Val 
        275                 280                 285             

Arg Pro Glu Asp Leu His Asp Glu Glu Val Phe Met Thr Thr Tyr Pro 
    290                 295                 300                 

Asp Ser Val Leu Gln Met Gln Val Glu Val Val Glu His Met Gly Ser 
305                 310                 315                 320 

Glu Val Tyr Leu His Thr Ser Ile Gly Pro Asn Thr Ile Val Ala Arg 
                325                 330                 335     

Val Asn Pro Arg His Val Tyr His Val Gly Ser Ser Val Lys Leu Ala 
            340                 345                 350         

Ile Asp Leu Asn Lys Ile His Ile Phe Asp Ala Glu Thr Glu Glu Ser 
        355                 360                 365             

Ile Gly Phe Ala Ala Gly Pro Ala Gly Glu Arg Gln Glu Ala Leu Val 
    370                 375                 380                 

<210>   128
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   128
Met Ala Arg Val Leu Leu Glu His Ile Tyr Lys Thr Tyr Pro Gly Gln 
                5                   10                  15      

Thr Glu Pro Thr Val Lys Asp Phe Asn Leu Asp Ile Gln Asp Lys Glu 
            20                  25                  30          

Phe Thr Val Phe Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu 
        35                  40                  45              

Arg Met Ile Ala Gly Leu Glu Asp Ile Thr Glu Gly Asn Leu Tyr Ile 
    50                  55                  60                  

Gly Asp Arg Arg Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Gln 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Lys Ala Glu Ile 
            100                 105                 110         

Asp Arg Arg Val Gln Glu Ala Ala Lys Ile Leu Asp Ile Ala His Leu 
        115                 120                 125             

Leu Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Leu Gly Arg Ala Ile Val Arg Glu Pro Gln Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Ala 
                165                 170                 175     

Asp Ile Arg Lys Leu His Gln Arg Leu Gln Thr Thr Val Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Met Gly Asp Arg Ile Val Val 
        195                 200                 205             

Met Arg Asp Gly Val Ile Gln Gln Ala Asp Thr Pro Gln Val Val Tyr 
    210                 215                 220                 

Ser Gln Pro Lys Asn Met Phe Val Ala Gly Phe Ile Gly Ser Pro Ala 
225                 230                 235                 240 

Met Asn Phe Ile Arg Gly Glu Ile Val Gln Asp Gly Asp Ala Phe Tyr 
                245                 250                 255     

Phe Arg Ala Pro Ser Ile Ser Leu Arg Leu Pro Glu Gly Arg Tyr Gly 
            260                 265                 270         

Val Leu Lys Ala Ser Gly Ala Ile Gly Lys Pro Val Val Leu Gly Val 
        275                 280                 285             

Arg Pro Glu Asp Leu His Asp Glu Glu Val Phe Met Thr Thr Tyr Pro 
    290                 295                 300                 

Asp Ser Val Leu Gln Met Gln Val Glu Val Val Glu His Met Gly Ser 
305                 310                 315                 320 

Glu Val Tyr Leu His Thr Ser Ile Gly Pro Asn Thr Ile Val Ala Arg 
                325                 330                 335     

Val Asn Pro Arg His Val Tyr His Val Gly Ser Ser Val Lys Leu Ala 
            340                 345                 350         

Ile Asp Leu Asn Lys Ile His Ile Phe Asp Ala Glu Thr Glu Glu Ser 
        355                 360                 365             

Ile Gly Phe Ala Ala Gly Pro Ala Gly Glu Arg Gln Glu Ala Leu Val 
    370                 375                 380                 

<210>   129
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   129
Met Ala Arg Val Leu Leu Glu His Ile Tyr Lys Thr Tyr Pro Gly Gln 
                5                   10                  15      

Thr Glu Pro Thr Val Lys Asp Phe Asn Leu Asp Ile Gln Asp Lys Glu 
            20                  25                  30          

Phe Thr Val Phe Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu 
        35                  40                  45              

Arg Met Ile Ala Gly Leu Glu Asp Ile Thr Glu Gly Gln Leu Tyr Ile 
    50                  55                  60                  

Gly Asp Arg Arg Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Gln 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Lys Ala Glu Ile 
            100                 105                 110         

Asp Arg Arg Val Gln Glu Ala Ala Lys Ile Leu Asp Ile Ala His Leu 
        115                 120                 125             

Leu Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Leu Gly Arg Ala Ile Val Arg Glu Pro Gln Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Ala 
                165                 170                 175     

Glu Ile Arg Lys Leu His Gln Arg Leu Gln Thr Thr Val Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Met Gly Asp Arg Ile Val Val 
        195                 200                 205             

Met Arg Asp Gly Val Ile Gln Gln Ala Asp Thr Pro Gln Val Val Tyr 
    210                 215                 220                 

Ser Gln Pro Lys Asn Met Phe Val Ala Gly Phe Ile Gly Ser Pro Ala 
225                 230                 235                 240 

Met Asn Phe Ile Arg Gly Glu Ile Val Gln Asp Gly Asp Ala Phe Tyr 
                245                 250                 255     

Phe Arg Ala Pro Ser Ile Ser Leu Arg Leu Pro Glu Gly Arg Tyr Gly 
            260                 265                 270         

Val Leu Lys Ala Ser Gly Ala Ile Gly Lys Pro Val Val Leu Gly Val 
        275                 280                 285             

Arg Pro Glu Asp Leu His Asp Glu Glu Val Phe Met Thr Thr Tyr Pro 
    290                 295                 300                 

Asp Ser Val Leu Gln Met Gln Val Glu Val Val Glu His Met Gly Ser 
305                 310                 315                 320 

Glu Val Tyr Leu His Thr Ser Ile Gly Pro Asn Thr Ile Val Ala Arg 
                325                 330                 335     

Val Asn Pro Arg His Val Tyr His Val Gly Ser Ser Val Lys Leu Ala 
            340                 345                 350         

Ile Asp Leu Asn Lys Ile His Ile Phe Asp Ala Glu Thr Glu Glu Ser 
        355                 360                 365             

Ile Gly Phe Ala Ala Gly Pro Ala Gly Glu Arg Gln Glu Ala Leu Val 
    370                 375                 380                 

<210>   130
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   130
Met Ala Arg Val Leu Leu Glu His Ile Tyr Lys Thr Tyr Pro Gly Gln 
                5                   10                  15      

Thr Glu Pro Thr Val Lys Asp Phe Asn Leu Asp Ile Gln Asp Lys Glu 
            20                  25                  30          

Phe Thr Val Phe Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu 
        35                  40                  45              

Arg Met Ile Ala Gly Leu Glu Asp Ile Thr Glu Gly Asn Leu Tyr Ile 
    50                  55                  60                  

Gly Asp Arg Arg Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Gln 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Lys Ala Glu Ile 
            100                 105                 110         

Asp Arg Arg Val Gln Glu Ala Ala Lys Ile Leu Asp Ile Ala His Leu 
        115                 120                 125             

Leu Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Leu Gly Arg Ala Ile Val Arg Glu Pro Gln Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Ala 
                165                 170                 175     

Glu Ile Arg Lys Leu His Gln Arg Leu Gln Thr Thr Val Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Met Gly Asp Arg Ile Val Val 
        195                 200                 205             

Met Arg Asp Gly Val Ile Gln Gln Ala Asp Thr Pro Gln Val Val Tyr 
    210                 215                 220                 

Ser Gln Pro Lys Asn Met Phe Val Ala Gly Phe Ile Gly Ser Pro Ala 
225                 230                 235                 240 

Met Asn Phe Ile Arg Gly Glu Ile Val Gln Asp Gly Asp Ala Phe Tyr 
                245                 250                 255     

Phe Arg Ala Pro Ser Ile Ser Leu Arg Leu Pro Glu Gly Arg Tyr Gly 
            260                 265                 270         

Val Leu Lys Ala Ser Gly Ala Ile Gly Lys Pro Val Val Leu Gly Val 
        275                 280                 285             

Arg Pro Glu Asp Leu His Asp Glu Glu Val Phe Met Thr Thr Tyr Pro 
    290                 295                 300                 

Asp Ser Val Leu Gln Met Gln Val Glu Val Val Glu His Met Gly Ser 
305                 310                 315                 320 

Glu Val Tyr Leu His Thr Ser Ile Gly Pro Asn Thr Ile Val Ala Arg 
                325                 330                 335     

Val Asn Pro Arg His Val Tyr His Val Gly Ser Ser Val Lys Leu Ala 
            340                 345                 350         

Ile Asp Leu Asn Arg Ile His Ile Phe Asp Ala Glu Thr Glu Glu Ser 
        355                 360                 365             

Ile Gly Phe Ala Ala Gly Pro Ala Gly Glu Arg Gln Glu Ala Leu Val 
    370                 375                 380                 

<210>   131
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   131
Met Ala Arg Val Leu Leu Glu His Ile Tyr Lys Thr Tyr Pro Gly Gln 
                5                   10                  15      

Thr Glu Pro Thr Val Arg Asp Phe Asn Leu Asp Ile Gln Asp Lys Glu 
            20                  25                  30          

Phe Thr Val Phe Val Gly Pro Ser Gly Cys Gly Lys Thr Thr Thr Leu 
        35                  40                  45              

Arg Met Ile Ala Gly Leu Glu Asp Ile Thr Glu Gly Asn Leu Tyr Ile 
    50                  55                  60                  

Gly Asp Arg Arg Val Asn Asp Val Pro Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Gln 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Val Pro Lys Ala Glu Ile 
            100                 105                 110         

Asp Arg Arg Val Gln Glu Ala Ala Lys Ile Leu Asp Ile Ala His Leu 
        115                 120                 125             

Leu Asp Arg Lys Pro Lys Ala Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Leu Gly Arg Ala Ile Val Arg Glu Pro Gln Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Gln Met Arg Ala 
                165                 170                 175     

Glu Ile Arg Lys Leu His Gln Arg Leu Gln Thr Thr Val Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Met Gly Asp Arg Ile Val Val 
        195                 200                 205             

Met Arg Asp Gly Val Ile Gln Gln Ala Asp Thr Pro Gln Val Val Tyr 
    210                 215                 220                 

Ser Gln Pro Lys Asn Met Phe Val Ala Gly Phe Ile Gly Ser Pro Ala 
225                 230                 235                 240 

Met Asn Phe Ile Arg Gly Glu Ile Val Gln Asp Gly Asp Ala Phe Tyr 
                245                 250                 255     

Phe Arg Ala Pro Ser Ile Ser Leu Arg Leu Pro Glu Gly Arg Tyr Gly 
            260                 265                 270         

Val Leu Lys Ala Ser Gly Ala Ile Gly Lys Pro Val Val Leu Gly Val 
        275                 280                 285             

Arg Pro Glu Asp Leu His Asp Glu Glu Val Phe Met Thr Thr Tyr Pro 
    290                 295                 300                 

Asp Ser Val Leu Gln Met Gln Val Glu Val Val Glu His Met Gly Ser 
305                 310                 315                 320 

Glu Val Tyr Leu His Thr Ser Ile Gly Pro Asn Thr Ile Val Ala Arg 
                325                 330                 335     

Val Asn Pro Arg His Val Tyr His Val Gly Ser Ser Val Lys Leu Ala 
            340                 345                 350         

Ile Asp Leu Asn Lys Ile His Ile Phe Asp Ala Glu Thr Glu Glu Ser 
        355                 360                 365             

Ile Gly Phe Ala Ala Gly Pro Ala Gly Glu Arg Gln Glu Ala Leu Val 
    370                 375                 380                 

<210>   132
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   132
gtggctcgcg tgttgctcga tcacatttac aagacctacc ccggccagac ggagccgacg       60

gtgaaggact tcaacctcga cattcaggac aaggaattca ccgtgttcgt cggcccctcc      120

ggctgcggca agacgacgac gcttcgcatg atcgctggac tcgaggacat cacggagggc      180

aacctgtata tcggcgatcg ccgcgtgaac gacgtgccgc cgaaggatcg ggacattgcg      240

atggtgttcc aaaactacgc gctctatccc catatgacgg tgtatcagaa catggcgttc      300

ggcctgaagc tgcgcaaggt gccgaaggcc gagatcgacc ggcgggtgca ggaggcggcg      360

aagatcctcg acatcgcgca cctgctcgac cggaagccga aggcgctctc cggcggtcag      420

cgccagcgcg tggcgttggg tcgcgccatt gtgcgcgagc cgcaggtgtt cctgatggat      480

gagccgctgt cgaacctgga cgcgaagctg cgcgtgcaga tgcgcgcgga gatccgcaag      540

ctccatcagc gcttgcaaac gaccgtcatt tacgttacac atgatcagac ggaagccatg      600

acgatgggcg atcgcatcgt ggtcatgcgc gacggcgtca tccagcaggc ggatacgccg      660

caggtcgtgt actcccagcc gaagaacatg tttgtcgccg gcttcattgg gtctcctgcc      720

atgaacttta ttcgcggcga gatcgtgcag gacggcgatg cgttctactt ccgcgcgcct      780

tccatttcgc tgcgcctgcc ggagggccgc tacggcgtgc tgaaggcgtc gggggccatt      840

gggaagccgg tcgtgctcgg cgtgcggccg gaagacctgc acgatgagga agtgttcatg      900

acgacgtatc ccgactccgt gctgcagatg caggtggaag tcgtggaaca catgggctcg      960

gaggtctatc tgcacacgag tatcgggccg aacacgatcg tcgcgcgcgt gaacccgcgc     1020

cacgtctacc acgtcggaag ctcggtcaag ctcgcgattg acttgaacaa gatccacatc     1080

ttcgacgcgg agacggagga gtccatcggc ttcgccgcag gtcctgcggg tgaacgtcaa     1140

gaagctttgg tgtga                                                      1155


<210>   133
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   133
gtggctcgcg tgttgctcga gcacatttac aagacctacc ccggccagac ggagccgacg       60

gtgaaggact tcaacctcga cattcaggac aaggaattca ccgtgttcgt cggcccctcc      120

ggctgcggca agacgacgac gcttcgcatg atcgctggac tcgaggacat cacggagggc      180

aacctgtata tcggcgatcg ccgcgtgaac gacgtgccgc cgaaggatcg ggacattgcg      240

atggtgttcc aaaactacgc gctctatccc catatgacgg tgtatcagaa catggcgttc      300

ggcctgaagc tgcgcaaggt gccgaaggcc gagatcgacc ggcgggtgca ggaggcggcg      360

aagatcctcg acatcgcgca cctgctcgac cggaagccga aggcgctctc cggcggtcag      420

cgccagcgcg tggcgttggg tcgcgccatt gtgcgcgagc cgcaggtgtt cctgatggat      480

gagccgctgt cgaacctgga cgcgaagctg cgcgtgcaga tgcgcgcgga tatccgcaag      540

ctccatcagc gcttgcaaac gaccgtcatt tacgttacac atgatcagac ggaagccatg      600

acgatgggcg atcgcatcgt ggtcatgcgc gacggcgtca tccagcaggc ggatacgccg      660

caggtcgtgt actcccagcc gaagaacatg tttgtcgccg gcttcattgg gtctcctgcc      720

atgaacttta ttcgcggcga gatcgtgcag gacggcgatg cgttctactt ccgcgcgcct      780

tccatttcgc tgcgcctgcc ggagggccgc tacggcgtgc tgaaggcgtc gggggccatt      840

gggaagccgg tcgtgctcgg cgtgcggccg gaagacctgc acgatgagga agtgttcatg      900

acgacgtatc ccgactccgt gctgcagatg caggtggaag tcgtggaaca catgggctcg      960

gaggtctatc tgcacacgag tatcgggccg aacacgatcg tcgcgcgcgt gaacccgcgc     1020

cacgtctacc acgtcggaag ctcggtcaag ctcgcgattg acttgaacaa gatccacatc     1080

ttcgacgcgg agacggagga gtccatcggc ttcgccgcag gtcctgcggg tgaacgtcaa     1140

gaagctttgg tgtga                                                      1155


<210>   134
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   134
gtggctcgcg tgttgctcga gcacatttac aagacctacc ccggccagac ggagccgacg       60

gtgaaggact tcaacctcga cattcaggac aaggaattca ccgtgttcgt cggcccctcc      120

ggctgcggca agacgacgac gcttcgcatg atcgctggac tcgaggacat cacggagggc      180

caactgtata tcggcgatcg ccgcgtgaac gacgtgccgc cgaaggatcg ggacattgcg      240

atggtgttcc aaaactacgc gctctatccc catatgacgg tgtatcagaa catggcgttc      300

ggcctgaagc tgcgcaaggt gccgaaggcc gagatcgacc ggcgggtgca ggaggcggcg      360

aagatcctcg acatcgcgca cctgctcgac cggaagccga aggcgctctc cggcggtcag      420

cgccagcgcg tggcgttggg tcgcgccatt gtgcgcgagc cgcaggtgtt cctgatggat      480

gagccgctgt cgaacctgga cgcgaagctg cgcgtgcaga tgcgcgcgga gatccgcaag      540

ctccatcagc gcttgcaaac gaccgtcatt tacgttacac atgatcagac ggaagccatg      600

acgatgggcg atcgcatcgt ggtcatgcgc gacggcgtca tccagcaggc ggatacgccg      660

caggtcgtgt actcccagcc gaagaacatg tttgtcgccg gcttcattgg gtctcctgcc      720

atgaacttta ttcgcggcga gatcgtgcag gacggcgatg cgttctactt ccgcgcgcct      780

tccatttcgc tgcgcctgcc ggagggccgc tacggcgtgc tgaaggcgtc gggggccatt      840

gggaagccgg tcgtgctcgg cgtgcggccg gaagacctgc acgatgagga agtgttcatg      900

acgacgtatc ccgactccgt gctgcagatg caggtggaag tcgtggaaca catgggctcg      960

gaggtctatc tgcacacgag tatcgggccg aacacgatcg tcgcgcgcgt gaacccgcgc     1020

cacgtctacc acgtcggaag ctcggtcaag ctcgcgattg acttgaacaa gatccacatc     1080

ttcgacgcgg agacggagga gtccatcggc ttcgccgcag gtcctgcggg tgaacgtcaa     1140

gaagctttgg tgtga                                                      1155


<210>   135
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   135
gtggctcgcg tgttgctcga gcacatttac aagacctacc ccggccagac ggagccgacg       60

gtgaaggact tcaacctcga cattcaggac aaggaattca ccgtgttcgt cggcccctcc      120

ggctgcggca agacgacgac gcttcgcatg atcgctggac tcgaggacat cacggagggc      180

aacctgtata tcggcgatcg ccgcgtgaac gacgtgccgc cgaaggatcg ggacattgcg      240

atggtgttcc aaaactacgc gctctatccc catatgacgg tgtatcagaa catggcgttc      300

ggcctgaagc tgcgcaaggt gccgaaggcc gagatcgacc ggcgggtgca ggaggcggcg      360

aagatcctcg acatcgcgca cctgctcgac cggaagccga aggcgctctc cggcggtcag      420

cgccagcgcg tggcgttggg tcgcgccatt gtgcgcgagc cgcaggtgtt cctgatggat      480

gagccgctgt cgaacctgga cgcgaagctg cgcgtgcaga tgcgcgcgga gatccgcaag      540

ctccatcagc gcttgcaaac gaccgtcatt tacgttacac atgatcagac ggaagccatg      600

acgatgggcg atcgcatcgt ggtcatgcgc gacggcgtca tccagcaggc ggatacgccg      660

caggtcgtgt actcccagcc gaagaacatg tttgtcgccg gcttcattgg gtctcctgcc      720

atgaacttta ttcgcggcga gatcgtgcag gacggcgatg cgttctactt ccgcgcgcct      780

tccatttcgc tgcgcctgcc ggagggccgc tacggcgtgc tgaaggcgtc gggggccatt      840

gggaagccgg tcgtgctcgg cgtgcggccg gaagacctgc acgatgagga agtgttcatg      900

acgacgtatc ccgactccgt gctgcagatg caggtggaag tcgtggaaca catgggctcg      960

gaggtctatc tgcacacgag tatcgggccg aacacgatcg tcgcgcgcgt gaacccgcgc     1020

cacgtctacc acgtcggaag ctcggtcaag ctcgcgattg acttgaaccg tatccacatc     1080

ttcgacgcgg agacggagga gtccatcggc ttcgccgcag gtcctgcggg tgaacgtcaa     1140

gaagctttgg tgtga                                                      1155


<210>   136
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   136
gtggctcgcg tgttgctcga gcacatttac aagacctacc ccggccagac ggagccgacg       60

gtgcgtgact tcaacctcga cattcaggac aaggaattca ccgtgttcgt cggcccctcc      120

ggctgcggca agacgacgac gcttcgcatg atcgctggac tcgaggacat cacggagggc      180

aacctgtata tcggcgatcg ccgcgtgaac gacgtgccgc cgaaggatcg ggacattgcg      240

atggtgttcc aaaactacgc gctctatccc catatgacgg tgtatcagaa catggcgttc      300

ggcctgaagc tgcgcaaggt gccgaaggcc gagatcgacc ggcgggtgca ggaggcggcg      360

aagatcctcg acatcgcgca cctgctcgac cggaagccga aggcgctctc cggcggtcag      420

cgccagcgcg tggcgttggg tcgcgccatt gtgcgcgagc cgcaggtgtt cctgatggat      480

gagccgctgt cgaacctgga cgcgaagctg cgcgtgcaga tgcgcgcgga gatccgcaag      540

ctccatcagc gcttgcaaac gaccgtcatt tacgttacac atgatcagac ggaagccatg      600

acgatgggcg atcgcatcgt ggtcatgcgc gacggcgtca tccagcaggc ggatacgccg      660

caggtcgtgt actcccagcc gaagaacatg tttgtcgccg gcttcattgg gtctcctgcc      720

atgaacttta ttcgcggcga gatcgtgcag gacggcgatg cgttctactt ccgcgcgcct      780

tccatttcgc tgcgcctgcc ggagggccgc tacggcgtgc tgaaggcgtc gggggccatt      840

gggaagccgg tcgtgctcgg cgtgcggccg gaagacctgc acgatgagga agtgttcatg      900

acgacgtatc ccgactccgt gctgcagatg caggtggaag tcgtggaaca catgggctcg      960

gaggtctatc tgcacacgag tatcgggccg aacacgatcg tcgcgcgcgt gaacccgcgc     1020

cacgtctacc acgtcggaag ctcggtcaag ctcgcgattg acttgaacaa gatccacatc     1080

ttcgacgcgg agacggagga gtccatcggc ttcgccgcag gtcctgcggg tgaacgtcaa     1140

gaagctttgg tgtga                                                      1155


<210>   137
<211>   434
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   137
Met Ser Met Ala Gln Val Gly Leu His Pro Ser Val Arg Pro Arg Pro 
                5                   10                  15      

Ser Ala Ala Lys Lys Thr Ala Tyr Ala Ala Asn Gln Ile Ala Val Asn 
            20                  25                  30          

Met Leu Trp Gln Ala Phe Asn Ala Val Ala Val Tyr Asp Tyr Val Ala 
        35                  40                  45              

Tyr His Gly Val Ser Ala Val Arg Leu Ser Ser Gly Leu Ile Val Tyr 
    50                  55                  60                  

Gly Val Leu Asn Ala Leu Phe Asn Leu Val Ala Gly His Val Ser Asp 
65                  70                  75                  80  

Arg Thr Lys Thr Arg Phe Gly Arg Arg Ile Pro Tyr Val Ala Val Ala 
                85                  90                  95      

Ser Ile Pro Tyr Ala Val Cys Phe Ala Leu Leu Phe Ser Pro Pro His 
            100                 105                 110         

Leu Ser Gln Thr Gly Leu Val Val Tyr Phe Leu Ala Met Thr Phe Leu 
        115                 120                 125             

Phe Asp Leu Ala Phe Thr Phe Thr Ala Leu Asn Ala Asn Ala Leu Tyr 
    130                 135                 140                 

Pro Glu Met Tyr Pro Asp Pro Arg Asp Arg Ala Tyr Val Ser Ala Leu 
145                 150                 155                 160 

Gln Gln Val Phe Gly Ile Val Gly Leu Ile Ala Gly Val Ala Leu Ser 
                165                 170                 175     

Lys Ser Leu Gly Gln Ala Leu Gly Trp Ser Arg Met Ala Trp Ile Phe 
            180                 185                 190         

Ala Ala Val Ala Val Ala Ser Met Tyr Val Ser Leu Trp Gly Ser Phe 
        195                 200                 205             

Glu Thr Gly Asp Pro Ala Glu Pro Phe Ala Trp Arg Glu Ala Leu Arg 
    210                 215                 220                 

Glu Thr Phe Arg Asn Arg Ala Phe Ile Trp Tyr Val Ile Ala Ser Phe 
225                 230                 235                 240 

Leu Val Gln Phe Thr Thr Thr Leu Phe Thr Thr Ala Ser Ser Phe Tyr 
                245                 250                 255     

Thr Ser Tyr Val Val Arg Leu Ser Pro Leu Gln Asn Ser Leu Phe Leu 
            260                 265                 270         

Gly Gly Ile Phe Val Val Ala Met Pro Ile Ala Phe Val Trp Ala Arg 
        275                 280                 285             

Ala Ala Ile Arg Tyr Gly Ala Ser Arg Ser Ala Met Val Ala Ile Ala 
    290                 295                 300                 

Leu Tyr Ala Cys Val Glu Ala Leu Leu Leu Val Asp Arg Ser Pro Thr 
305                 310                 315                 320 

Ser Val Leu Val Thr Gly Leu Cys Leu Gly Val Pro Val Ala Gly Phe 
                325                 330                 335     

Met Val Leu Leu Asn Met Leu Leu Ala Glu Val Ile Asp Leu Asp Ala 
            340                 345                 350         

Arg Arg Thr Gly Arg Arg Arg Glu Gly Met Tyr Leu Gly Met Asn Gly 
        355                 360                 365             

Cys Ile Val Arg Leu Gly Leu Ser Leu Gln Tyr Ala Val Met Ala Ile 
    370                 375                 380                 

Phe Phe Ala Val Ser Gly Tyr Arg Ala Gly Ala Ser Val Gln Pro Thr 
385                 390                 395                 400 

Ser Ala Val Glu Gly Leu Arg Leu Leu Leu Gly Leu Val Pro Ala Leu 
                405                 410                 415     

Phe Leu Ala Gly Ala Phe Leu Cys Met Arg Val Tyr Asp Arg Thr Arg 
            420                 425                 430         

Thr Arg 
        

<210>   138
<211>   1305
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   138
gtgtccatgg cgcaagttgg cctccatcct tctgttcggc cgcgcccgtc ggctgcgaaa       60

aagaccgcat acgcagccaa tcaaatcgcc gtcaacatgc tttggcaggc gttcaacgcc      120

gtggcggtgt acgattacgt ggcctatcac ggcgtgtccg cggtccggct atcgagcggc      180

ctcatcgtct acggggtgct gaacgccttg ttcaacctcg tggcgggcca cgtgagcgac      240

cgcaccaaga cccgcttcgg ccggcgcatt ccgtacgtcg ccgtcgcatc catcccgtat      300

gccgtgtgtt tcgcgctttt gttctctccg ccacacctct cgcagaccgg cctcgtcgtg      360

tactttttgg ccatgacgtt cttgttcgat ctcgccttca ccttcacggc cctcaacgcg      420

aacgcgttgt acccggagat gtacccagat ccgcgcgatc gcgcgtacgt gtcggcgctt      480

cagcaggtct ttggcatcgt cgggctcatc gccggcgtcg ccttgtcgaa atcgcttggg      540

caggccctcg gctggtcgcg catggcctgg atcttcgccg cggtggccgt cgcgtcgatg      600

tacgtgtccc tctggggaag ctttgaaacg ggcgatcccg ccgaaccgtt cgcgtggcgg      660

gaggcgctgc gcgagacgtt ccgaaatcgc gcgttcattt ggtacgtgat cgcgagcttc      720

ctcgtccagt tcacgactac gctcttcacc acggcctcct cgttctacac gtcgtacgtg      780

gtgcgtctca gtccgctgca aaactcgctc tttctcggcg gaatcttcgt cgtcgcgatg      840

cccatcgcgt ttgtgtgggc tcgcgccgcg attcgatacg gcgcttcgcg gtcggccatg      900

gtcgccatcg cgctgtacgc gtgcgtcgag gcgctccttc tcgtcgatcg gtcgcccact      960

tccgtgctcg tgaccgggct ttgcctcggc gtccccgtcg cgggcttcat ggtcctcttg     1020

aacatgctct tggccgaggt gatcgatctc gacgcgcgcc gcacaggccg ccgccgcgaa     1080

gggatgtatc tgggcatgaa cgggtgcatc gtgcgactcg gcctatccct gcagtacgcc     1140

gtgatggcca tctttttcgc ggtctcgggc tatcgggcgg gcgccagcgt ccaaccgacg     1200

agtgcggtgg agggcttacg gctgttgctc ggcctcgtcc ctgcactctt tcttgcgggc     1260

gcgttcctgt gcatgcgggt gtacgaccga acgcgcacgc gatga                     1305


<210>   139
<211>   384
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   139
Lys Lys Val Ala Tyr Ser Phe Gly Asn Phe Pro Ile Gly Ile Met Leu 
                5                   10                  15      

Glu Ala Phe Gly Thr Tyr Val Met Phe Phe Tyr Ile Asp Val Leu Lys 
            20                  25                  30          

Val Asp Pro Ser Phe Ile Ser Leu Ala Phe Val Ile His Gly Ile Ile 
        35                  40                  45              

Phe Ala Ile Phe Asn Pro Leu Ile Gly Tyr Val Ser Asp Lys Thr Glu 
    50                  55                  60                  

Thr Arg Trp Gly Arg Arg Arg Pro Tyr Ile Ala Phe Gly Ile Val Pro 
65                  70                  75                  80  

Leu Ala Leu Val Phe Tyr Val Ile Trp Ser Pro Phe Val Ser Lys Glu 
                85                  90                  95      

Phe Leu Pro Ala Tyr Phe Leu Thr Val Ile Ile Leu Phe Asp Phe Leu 
            100                 105                 110         

Tyr Val Leu Val Gly Leu Asn Leu Ala Ala Leu Phe Pro Glu Met Phe 
        115                 120                 125             

Pro Ser Leu Glu Glu Arg Ala Gln Val Ser Ala Tyr Arg Gln Met Phe 
    130                 135                 140                 

Gly Ile Leu Gly Ser Ile Ile Gly Val Val Leu Pro Pro Ile Ile Tyr 
145                 150                 155                 160 

Ser Arg Tyr Gly Trp Asn Val Leu Gly Ile Ile Phe Gly Thr Leu Ile 
                165                 170                 175     

Ala Ile Gly Phe Phe Ile Ala Phe Tyr Gly Cys Glu Glu Lys Lys Asn 
            180                 185                 190         

Ile Lys Ile Pro Ser Ile Pro Val Leu Thr Ala Phe Lys Tyr Val Phe 
        195                 200                 205             

Leu Asn Lys Ala Phe Leu Pro Phe Val Val Gly Gly Phe Phe Ala Lys 
    210                 215                 220                 

Phe Leu Leu Thr Ser Val Pro Ala Ala Ile Pro Phe Phe Thr Lys Tyr 
225                 230                 235                 240 

Val Leu Arg Ile Pro Glu Lys Glu Val Ser Leu Leu Leu Gly Ser Ile 
                245                 250                 255     

Phe Val Thr Ala Ile Pro Met Met Leu Val Trp Ser Lys Ile Thr Lys 
            260                 265                 270         

Lys Phe Gly Ser Arg Lys Ala Met Phe Leu Ser Ile Gly Phe Leu Ile 
        275                 280                 285             

Leu Val Phe Pro Ala Tyr Phe Phe Val Asn Thr Phe Val Glu Thr Leu 
    290                 295                 300                 

Ile Val Ser Val Ile Phe Gly Ala Leu Leu Ala Gly Val Val Met Leu 
305                 310                 315                 320 

Leu Asp Val Met Leu Ala Glu Val Ile Asp Glu Asp Thr Lys Asn Thr 
                325                 330                 335     

Gly Met Lys Arg Glu Gly Met Tyr Thr Gly Val Phe Gly Phe Ile Ile 
            340                 345                 350         

Arg Phe Gly Tyr Ser Leu Gln Gly Ile Val Ile Gly Gly Ile Leu Lys 
        355                 360                 365             

Leu Ser Gly Tyr Ile Pro Asn Val Leu Glu Gln Pro Ser Ser Ala Ile 
    370                 375                 380                 

<210>   140
<211>   390
<212>   PRT
<213>   Thermotoga lettingae TMO

<400>   140
Lys Asn Phe Leu Tyr Ser Leu Gly Ser Phe Ser Ser Ala Leu Phe Ser 
                5                   10                  15      

Asn Ala Ile Ser Thr Phe Ala Ile Phe Tyr Tyr Val Asp Val Leu Lys 
            20                  25                  30          

Ala Pro Pro His Leu Ile Ser Ile Ile Met Val Leu Tyr Gly Ile Trp 
        35                  40                  45              

Asn Ala Ile Asn Asp Pro Leu Phe Gly Tyr Leu Ser Asp Thr Thr Lys 
    50                  55                  60                  

Thr Arg Trp Gly Arg Arg Lys Pro Tyr Ile Val Trp Phe Ser Leu Pro 
65                  70                  75                  80  

Leu Thr Ile Ser Phe Ala Met Phe Trp Ala Pro Pro Phe Asp Ser Ser 
                85                  90                  95      

Gln Lys Thr Ala Leu Val Ile Tyr Tyr Leu Ile Met Ile Phe Leu Phe 
            100                 105                 110         

Asp Thr Phe Phe Thr Ile Val Phe Leu Asn Trp Thr Ala Leu Phe Pro 
        115                 120                 125             

Glu Met Tyr Pro Thr Leu Lys Glu Arg Ala Lys Ile Ser Gly Leu Arg 
    130                 135                 140                 

Gln Ile Leu Ala Ile Pro Gly Leu Leu Leu Gly Val Ala Val Thr Pro 
145                 150                 155                 160 

Val Ile Ala Ala Lys Ile Gly Trp Gly Lys Met Gly Ala Val Phe Ala 
                165                 170                 175     

Val Ile Gly Gly Ser Ile Leu Tyr Met Thr Leu Phe Gly Ile Lys Glu 
            180                 185                 190         

Asn Pro Glu Phe Ser His Gln Gln Thr Leu Asn Ile Ile Glu Ala Ile 
        195                 200                 205             

Lys Phe Thr Phe Phe Asn Arg Ser Phe Phe Thr Tyr Val Val Pro Ser 
    210                 215                 220                 

Phe Leu Leu Gln Phe Thr Tyr Thr Met Leu Thr Ala Thr Leu Pro Phe 
225                 230                 235                 240 

Tyr Ala Lys Tyr Val Leu Lys Ala Ser Glu Thr Gln Thr Thr Leu Leu 
                245                 250                 255     

Leu Ala Ser Ile Phe Val Val Ala Phe Phe Leu Ile Pro Val Trp Gln 
            260                 265                 270         

Lys Ile Thr Ala Lys Ile Gly Ala Lys Lys Thr Met Lys Val Ser Met 
        275                 280                 285             

Ile Leu Trp Ala Ile Leu Leu Ile Gly Phe Gly Phe Val Lys Thr Phe 
    290                 295                 300                 

Phe Gln Ala Ile Ile Leu Thr Ser Ala Leu Ala Met Ser Leu Ala Gly 
305                 310                 315                 320 

Ala Leu Ile Val Phe Asp Ile Met Ile Ala Asp Ile Ser Asp Glu Asp 
                325                 330                 335     

Glu Ile Lys Thr Gly Lys Arg Arg Glu Gly Met Tyr Phe Gly Ala Asn 
            340                 345                 350         

Ala Leu Ile Ile Arg Leu Gly Ile Ser Leu Asn Ser Leu Ile Met Gly 
        355                 360                 365             

Phe Val Leu Ser Ser Ser Gly Tyr Asp Ala Asn Leu Pro Ala Glu Met 
    370                 375                 380                 

Gln Pro Leu Thr Ala Val 
385                 390 

<210>   141
<211>   381
<212>   PRT
<213>   Thermus thermophilus HB8

<400>   141
Ala Tyr Ala Leu Gly Gly Leu Gly Leu Thr Leu Pro Ala Gln Thr Phe 
                5                   10                  15      

Gly Thr Tyr Leu Ala Phe Tyr Tyr Leu Asp Arg Leu Gly Met Pro Ala 
            20                  25                  30          

Gly Ala Phe Ala Leu Ala Arg Leu Ile Phe Ser Val Trp Asp Ala Val 
        35                  40                  45              

Asn Asp Pro Leu Phe Gly Tyr Leu Ser Asp Arg Thr Arg Thr Pro Trp 
    50                  55                  60                  

Gly Arg Arg Arg Pro Trp Leu Phe Leu Ser Leu Pro Phe Leu Leu Leu 
65                  70                  75                  80  

Ala Phe Tyr Leu Ala Phe Ser Val Pro Glu Ala Phe Arg Lys Gly Thr 
                85                  90                  95      

Arg Leu Phe Trp Tyr Gly Leu Trp Ala Met Leu Leu Phe Glu Thr Phe 
            100                 105                 110         

Ser Ala Leu Ala Trp Val Asn His Ala Ala Leu Phe Pro Glu Leu Phe 
        115                 120                 125             

Gln Ser Arg Glu Glu Arg Ala Arg Ala Asn Ala Trp Arg Gln Gly Phe 
    130                 135                 140                 

Tyr Phe Leu Gly Leu Thr Ala Ser Ile Ala Leu Thr Pro Leu Val Tyr 
145                 150                 155                 160 

Ala Ala Leu Gly Phe Pro Gly Met Ala Leu Leu Tyr Gly Ala Val Gly 
                165                 170                 175     

Gly Gly Leu Val Leu Leu Phe Leu Leu Ser Val Arg Glu Asp Pro Arg 
            180                 185                 190         

Ala Arg Glu Ala Glu Pro Leu Pro Phe Val Pro Ala Phe Arg Tyr Thr 
        195                 200                 205             

Leu Gly Asn Arg Ala Phe Trp Ile Tyr Ala Leu Ala Ala Leu Phe Leu 
    210                 215                 220                 

Leu Phe Ala Val Gly Leu Phe Ala Ala Ala Met Pro Phe Tyr Ala Lys 
225                 230                 235                 240 

His Ala Leu Gly Leu Gly Glu Glu Ala Thr Ala Leu Leu Phe Ala Ser 
                245                 250                 255     

Val Leu Leu Ala Ala Leu Pro Ser Val Ser Leu Trp Ala Arg Leu Ala 
            260                 265                 270         

Gly Ala Leu Gly Pro Lys Arg Ala Trp Leu Trp Ala Ile Gly Leu Leu 
        275                 280                 285             

Ala Leu Gly Ala Leu Leu Leu Leu Trp Pro Arg Gly Leu Leu Glu Ala 
    290                 295                 300                 

Leu Pro Val Gly Val Leu Ile Gly Thr Gly Phe Gly Gly Val Leu Val 
305                 310                 315                 320 

Leu Gly Asp Val Leu Leu Ala Glu Val Ile Asp Arg Asp Ala Ala Ala 
                325                 330                 335     

Thr Gly Arg Arg Arg Glu Gly Val Tyr Tyr Ser Val Tyr Gly Phe Ile 
            340                 345                 350         

Asn Arg Leu Ser Gly Pro Leu Gln Ala Leu Ala Phe Ala Leu Leu Thr 
        355                 360                 365             

Pro Leu Phe Gly Tyr Val Ser Gly Glu Asn Pro Gly Pro 
    370                 375                 380     

<210>   142
<211>   381
<212>   PRT
<213>   Thermus thermophilus HB27

<400>   142
Ala Tyr Ala Leu Gly Gly Leu Gly Leu Thr Leu Pro Ala Gln Thr Phe 
                5                   10                  15      

Gly Thr Tyr Leu Ala Phe Tyr Tyr Leu Asp Arg Leu Gly Met Pro Thr 
            20                  25                  30          

Gly Ala Phe Ala Leu Ala Arg Leu Ile Phe Ser Val Trp Asp Ala Val 
        35                  40                  45              

Asn Asp Pro Leu Phe Gly Tyr Leu Ser Asp Arg Thr Arg Thr Pro Trp 
    50                  55                  60                  

Gly Arg Arg Arg Pro Trp Leu Phe Leu Ser Leu Pro Phe Leu Leu Leu 
65                  70                  75                  80  

Ala Phe Tyr Leu Ala Phe Ser Val Pro Glu Ala Phe Arg Glu Gly Thr 
                85                  90                  95      

Arg Leu Phe Trp Tyr Gly Leu Trp Ala Met Leu Leu Phe Glu Thr Phe 
            100                 105                 110         

Ser Ala Leu Ala Trp Val Asn His Ala Ala Leu Phe Pro Glu Leu Phe 
        115                 120                 125             

Gln Ser Arg Glu Glu Arg Ala Arg Ala Asn Ala Trp Arg Gln Gly Phe 
    130                 135                 140                 

Tyr Phe Leu Gly Leu Thr Ala Ser Ile Ala Leu Thr Pro Leu Val Tyr 
145                 150                 155                 160 

Ala Ala Leu Gly Phe Pro Gly Met Ala Leu Leu Tyr Gly Ala Val Gly 
                165                 170                 175     

Gly Gly Leu Val Leu Leu Phe Leu Leu Ser Val Arg Glu Asp Pro Arg 
            180                 185                 190         

Ala Arg Glu Ala Glu Pro Leu Pro Phe Val Pro Ala Phe Arg Tyr Thr 
        195                 200                 205             

Leu Gly Asn Arg Ala Phe Trp Ile Tyr Ala Leu Ala Ala Leu Phe Leu 
    210                 215                 220                 

Leu Phe Ala Val Gly Leu Phe Ala Ala Ala Met Pro Phe Tyr Ala Lys 
225                 230                 235                 240 

Tyr Ala Leu Gly Leu Gly Glu Glu Ala Thr Ala Leu Leu Phe Ala Ser 
                245                 250                 255     

Val Leu Leu Ala Ala Leu Pro Ser Val Ser Leu Trp Ala Arg Leu Ala 
            260                 265                 270         

Gly Ala Leu Gly Pro Lys Arg Ala Trp Leu Trp Ala Ile Gly Leu Leu 
        275                 280                 285             

Ala Leu Gly Ala Leu Leu Leu Leu Trp Pro Arg Gly Leu Leu Glu Ala 
    290                 295                 300                 

Leu Pro Val Gly Val Leu Ile Gly Thr Gly Phe Gly Gly Val Leu Val 
305                 310                 315                 320 

Leu Gly Asp Val Leu Leu Ala Glu Val Ile Asp Arg Asp Ala Ala Ala 
                325                 330                 335     

Thr Gly Arg Arg Arg Glu Gly Val Tyr Tyr Ser Val Tyr Gly Phe Val 
            340                 345                 350         

Asn Arg Leu Ser Gly Pro Leu Gln Ala Leu Ala Phe Ala Leu Leu Thr 
        355                 360                 365             

Pro Leu Phe Gly Tyr Val Ser Gly Glu Asn Pro Gly Pro 
    370                 375                 380     

<210>   143
<211>   394
<212>   PRT
<213>   Roseiflexus castenholzii DSM 13941

<400>   143
Ala Tyr Ser Met Gly Asn Phe Ala Asn Thr Ile Ala Tyr Gln Val Phe 
                5                   10                  15      

Gly Asn Arg Ile Gln Phe Tyr Tyr Val Asp Val Leu Gly Leu Asn Ala 
            20                  25                  30          

Ala Ala Ala Gly Val Ile Trp Thr Ile Tyr Gly Leu Trp Asn Ala Ile 
        35                  40                  45              

Asn Asp Pro Leu Met Gly Gln Leu Ser Asp Arg Thr Arg Thr Pro Met 
    50                  55                  60                  

Gly Arg Arg Val Pro Tyr Val Leu Phe Gly Ala Val Pro Leu Gly Leu 
65                  70                  75                  80  

Ser Phe Phe Phe Leu Trp Thr Pro Pro Gly Gln Ser Pro Trp Leu Leu 
                85                  90                  95      

Ala Ala Tyr Phe Leu Ile Ile Leu Phe Ile Phe Asp Thr Leu Tyr Ser 
            100                 105                 110         

Leu Thr Ile Ile Ala Tyr Asn Ala Leu Phe Pro Glu Val Ala Pro His 
        115                 120                 125             

Leu Lys Ala Arg Ile Asp Leu Ser Ala Val Arg Glu Val Leu Ala Thr 
    130                 135                 140                 

Ile Ala Leu Leu Leu Ser Phe Ile Leu Ala Pro Ile Leu Ala Glu Gly 
145                 150                 155                 160 

Val Gly Tyr Ile Trp Met Gly Ala Ile Met Gly Thr Leu Val Ala Val 
                165                 170                 175     

Gly Tyr Leu Ile Ser Met Ala Gly Val Arg Glu Asp Ile Ser Lys Ile 
            180                 185                 190         

Lys Asp Asp Arg Phe Gly Leu Ile Glu Ser Leu Arg Ile Ala Leu Ser 
        195                 200                 205             

Ser Arg Pro Phe Arg Trp Phe Ile Gly Ala Asn Ile Ala Lys Glu Tyr 
    210                 215                 220                 

Ile Trp Leu Val Leu Ala Ala Met Leu Pro Phe Trp Arg Lys Tyr Ala 
225                 230                 235                 240 

Leu Gly Ile Gln Gly Gln Thr Glu Val Phe Gly Met Arg Leu Ser Gly 
                245                 250                 255     

Gly Asp Ala Glu Ala Ile Leu Leu Gly Val Pro Ile Leu Leu Thr Ile 
            260                 265                 270         

Pro Met Leu Leu Ile Trp Arg Pro Met Val Ala Arg Ile Gly Pro Arg 
        275                 280                 285             

Arg Ser Trp Ile Ile Thr Ser Phe Cys Phe Ile Pro Gly Phe Leu Ala 
    290                 295                 300                 

Met Ile Leu Ala Asn Asp Phe Tyr Thr Gly Leu Ile Gly Thr Leu Leu 
305                 310                 315                 320 

Val Val Pro Gly Leu Ala Gly Ser Met Ile Met Pro Phe Pro Leu Ile 
                325                 330                 335     

Ser Glu Val Ile Asp Asp Asp Ala Ala Arg His Gly Tyr Arg Arg Glu 
            340                 345                 350         

Gly Ile Phe Phe Gly Ile Asn Gly Gly Ile Thr Lys Leu Ala Phe Ser 
        355                 360                 365             

Ala Gln Gly Val Leu Phe Ala Ala Val Leu Ser Leu Ser Gly Tyr Val 
    370                 375                 380                 

Ala Gly Ser Asp Ala Gln Pro Glu Ser Ala 
385                 390                 

<210>   144
<211>   434
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   144
Met Ser Met Ala Gln Val Gly Leu His Pro Ser Val Arg Pro Arg Pro 
                5                   10                  15      

Ser Ala Ala Lys Arg Thr Ala Tyr Ala Ala Asn Gln Ile Ala Val Asn 
            20                  25                  30          

Met Leu Trp Gln Ala Phe Asn Ala Val Ala Val Tyr Asp Tyr Val Ala 
        35                  40                  45              

Tyr His Gly Val Ser Ala Val Arg Leu Ser Ser Gly Leu Ile Val Tyr 
    50                  55                  60                  

Gly Val Leu Asn Ala Leu Phe Asn Leu Val Ala Gly His Val Ser Asp 
65                  70                  75                  80  

Arg Thr Lys Thr Arg Phe Gly Arg Arg Ile Pro Tyr Val Ala Val Ala 
                85                  90                  95      

Ser Ile Pro Tyr Ala Val Cys Phe Ala Leu Leu Phe Ser Pro Pro His 
            100                 105                 110         

Leu Ser Gln Thr Gly Leu Val Val Tyr Phe Leu Ala Met Thr Phe Leu 
        115                 120                 125             

Phe Asp Leu Ala Phe Thr Phe Thr Ala Leu Asn Ala Asn Ala Leu Tyr 
    130                 135                 140                 

Pro Glu Met Tyr Pro Asp Pro Arg Asp Arg Ala Tyr Val Ser Ala Leu 
145                 150                 155                 160 

Gln Gln Val Phe Gly Ile Val Gly Leu Ile Ala Gly Val Ala Leu Ser 
                165                 170                 175     

Lys Ser Leu Gly Gln Ala Leu Gly Trp Ser Arg Met Ala Trp Ile Phe 
            180                 185                 190         

Ala Ala Val Ala Val Ala Ser Met Tyr Val Ser Leu Trp Gly Ser Phe 
        195                 200                 205             

Glu Thr Gly Asp Pro Ala Glu Pro Phe Ala Trp Arg Glu Ala Leu Arg 
    210                 215                 220                 

Glu Thr Phe Arg Asn Arg Ala Phe Ile Trp Tyr Val Ile Ala Ser Phe 
225                 230                 235                 240 

Leu Val Gln Phe Thr Thr Thr Leu Phe Thr Thr Ala Ser Ser Phe Tyr 
                245                 250                 255     

Thr Ser Tyr Val Val Arg Leu Ser Pro Leu Gln Asn Ser Leu Phe Leu 
            260                 265                 270         

Gly Gly Ile Phe Val Val Ala Met Pro Ile Ala Phe Val Trp Ala Arg 
        275                 280                 285             

Ala Ala Ile Arg Tyr Gly Ala Ser Arg Ser Ala Met Val Ala Ile Ala 
    290                 295                 300                 

Leu Tyr Ala Cys Val Glu Ala Leu Leu Leu Val Asp Arg Ser Pro Thr 
305                 310                 315                 320 

Ser Val Leu Val Thr Gly Leu Cys Leu Gly Val Pro Val Ala Gly Phe 
                325                 330                 335     

Met Val Leu Leu Asn Met Leu Leu Ala Glu Val Ile Asp Leu Asp Ala 
            340                 345                 350         

Arg Arg Thr Gly Arg Arg Arg Glu Gly Met Tyr Leu Gly Met Asn Gly 
        355                 360                 365             

Cys Ile Val Arg Leu Gly Leu Ser Leu Gln Tyr Ala Val Met Ala Ile 
    370                 375                 380                 

Phe Phe Ala Val Ser Gly Tyr Arg Ala Gly Ala Ser Val Gln Pro Thr 
385                 390                 395                 400 

Ser Ala Val Glu Gly Leu Arg Leu Leu Leu Gly Leu Val Pro Ala Leu 
                405                 410                 415     

Phe Leu Ala Gly Ala Phe Leu Cys Met Arg Val Tyr Asp Arg Thr Arg 
            420                 425                 430         

Thr Arg 
        

<210>   145
<211>   434
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   145
Met Ser Met Ala Gln Val Gly Leu His Pro Ser Val Arg Pro Arg Pro 
                5                   10                  15      

Ser Ala Ala Lys Lys Thr Ala Tyr Ala Ala Asn Gln Ile Ala Val Asn 
            20                  25                  30          

Met Leu Trp Gln Ala Phe Asn Ala Val Ala Val Tyr Asp Tyr Val Ala 
        35                  40                  45              

Tyr His Gly Val Ser Ala Val Arg Leu Ser Ser Gly Leu Ile Val Tyr 
    50                  55                  60                  

Gly Val Leu Asn Ala Leu Phe Asn Leu Val Ala Gly His Val Ser Asp 
65                  70                  75                  80  

Arg Thr Lys Thr Arg Phe Gly Arg Arg Ile Pro Tyr Val Ala Val Ala 
                85                  90                  95      

Ser Ile Pro Tyr Ala Val Cys Phe Ala Leu Leu Phe Ser Pro Pro His 
            100                 105                 110         

Leu Ser Gln Thr Gly Leu Val Val Tyr Phe Leu Ala Met Thr Phe Leu 
        115                 120                 125             

Phe Asp Leu Ala Phe Thr Phe Thr Ala Leu Asn Ala Asn Ala Leu Tyr 
    130                 135                 140                 

Pro Glu Met Tyr Pro Asp Pro Arg Asp Arg Ala Tyr Val Ser Ala Leu 
145                 150                 155                 160 

Gln Gln Val Phe Gly Ile Val Gly Leu Ile Ala Gly Val Ala Leu Ser 
                165                 170                 175     

Lys Ser Leu Gly Gln Ala Leu Gly Trp Ser Arg Met Ala Trp Ile Phe 
            180                 185                 190         

Ala Ala Val Ala Val Ala Ser Met Tyr Val Ser Leu Trp Gly Ser Phe 
        195                 200                 205             

Glu Thr Gly Asp Pro Ala Glu Pro Phe Ala Trp Arg Glu Ala Leu Arg 
    210                 215                 220                 

Glu Thr Phe Arg Asn Arg Ala Phe Ile Trp Tyr Val Ile Ala Ser Phe 
225                 230                 235                 240 

Leu Val Gln Phe Thr Thr Thr Leu Phe Thr Thr Ala Ser Ser Phe Tyr 
                245                 250                 255     

Thr Ser Tyr Val Val Arg Leu Ser Pro Leu Gln Asn Ser Leu Phe Leu 
            260                 265                 270         

Gly Gly Ile Phe Val Val Ala Met Pro Ile Ala Phe Val Trp Ala Arg 
        275                 280                 285             

Ala Ala Ile Arg Tyr Gly Ala Ser Arg Ser Ala Met Val Ala Ile Ala 
    290                 295                 300                 

Leu Tyr Ala Cys Val Glu Ala Leu Leu Leu Val Asp Arg Ser Pro Thr 
305                 310                 315                 320 

Ser Val Leu Val Thr Gly Leu Cys Leu Gly Val Pro Val Ala Gly Phe 
                325                 330                 335     

Met Val Leu Leu Asn Met Leu Leu Ala Glu Val Ile Asp Leu Asp Ala 
            340                 345                 350         

Arg Arg Thr Gly Arg Arg Arg Glu Gly Met Tyr Leu Gly Met Asn Gly 
        355                 360                 365             

Cys Ile Val Arg Leu Gly Leu Ser Leu Gln Tyr Ala Val Met Ala Ile 
    370                 375                 380                 

Phe Phe Ala Val Ser Gly Tyr Arg Ala Gly Ala Ser Val Gln Pro Thr 
385                 390                 395                 400 

Ser Ala Val Glu Gly Ile Arg Leu Leu Leu Gly Leu Val Pro Ala Leu 
                405                 410                 415     

Phe Leu Ala Gly Ala Phe Leu Cys Met Arg Val Tyr Asp Arg Thr Arg 
            420                 425                 430         

Thr Arg 
        

<210>   146
<211>   434
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   146
Met Ser Met Ala Gln Val Gly Leu His Pro Ser Val Arg Pro Arg Pro 
                5                   10                  15      

Ser Ala Ala Lys Lys Thr Ala Tyr Ala Ala Asn Gln Ile Ala Val Asn 
            20                  25                  30          

Met Leu Trp Gln Ala Phe Asn Ala Val Ala Val Tyr Asp Tyr Val Ala 
        35                  40                  45              

Tyr His Gly Val Ser Ala Val Arg Leu Ser Ser Gly Leu Ile Val Tyr 
    50                  55                  60                  

Gly Val Leu Asn Ala Leu Phe Asn Leu Val Ala Gly His Val Ser Asp 
65                  70                  75                  80  

Arg Thr Lys Thr Arg Phe Gly Arg Arg Ile Pro Tyr Val Ala Val Ala 
                85                  90                  95      

Ser Ile Pro Tyr Ala Val Cys Phe Ala Leu Leu Phe Ser Pro Pro His 
            100                 105                 110         

Leu Ser Gln Thr Gly Leu Val Val Tyr Phe Leu Ala Met Thr Phe Leu 
        115                 120                 125             

Phe Asp Leu Ala Phe Thr Phe Thr Ala Leu Asn Ala Asn Ala Leu Tyr 
    130                 135                 140                 

Pro Glu Met Tyr Pro Asp Pro Arg Asp Arg Ala Tyr Ile Ser Ala Leu 
145                 150                 155                 160 

Gln Gln Val Phe Gly Ile Val Gly Leu Ile Ala Gly Val Ala Leu Ser 
                165                 170                 175     

Lys Ser Leu Gly Gln Ala Leu Gly Trp Ser Arg Met Ala Trp Ile Phe 
            180                 185                 190         

Ala Ala Val Ala Val Ala Ser Met Tyr Val Ser Leu Trp Gly Ser Phe 
        195                 200                 205             

Glu Thr Gly Asp Pro Ala Glu Pro Phe Ala Trp Arg Glu Ala Leu Arg 
    210                 215                 220                 

Glu Thr Phe Arg Asn Arg Ala Phe Ile Trp Tyr Val Ile Ala Ser Phe 
225                 230                 235                 240 

Leu Val Gln Phe Thr Thr Thr Leu Phe Thr Thr Ala Ser Ser Phe Tyr 
                245                 250                 255     

Thr Ser Tyr Val Val Arg Leu Ser Pro Leu Gln Asn Ser Leu Phe Leu 
            260                 265                 270         

Gly Gly Ile Phe Val Val Ala Met Pro Ile Ala Phe Val Trp Ala Arg 
        275                 280                 285             

Ala Ala Ile Arg Tyr Gly Ala Ser Arg Ser Ala Met Val Ala Ile Ala 
    290                 295                 300                 

Leu Tyr Ala Cys Val Glu Ala Leu Leu Leu Val Asp Arg Ser Pro Thr 
305                 310                 315                 320 

Ser Val Leu Val Thr Gly Leu Cys Leu Gly Val Pro Val Ala Gly Phe 
                325                 330                 335     

Met Val Leu Leu Asn Met Leu Leu Ala Glu Val Ile Asp Leu Asp Ala 
            340                 345                 350         

Arg Arg Thr Gly Arg Arg Arg Glu Gly Met Tyr Leu Gly Met Asn Gly 
        355                 360                 365             

Cys Ile Val Arg Leu Gly Leu Ser Leu Gln Tyr Ala Val Met Ala Ile 
    370                 375                 380                 

Phe Phe Ala Val Ser Gly Tyr Arg Ala Gly Ala Ser Val Gln Pro Thr 
385                 390                 395                 400 

Ser Ala Val Glu Gly Leu Arg Leu Leu Leu Gly Leu Val Pro Ala Leu 
                405                 410                 415     

Phe Leu Ala Gly Ala Phe Leu Cys Met Arg Val Tyr Asp Arg Thr Arg 
            420                 425                 430         

Thr Arg 
        

<210>   147
<211>   434
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   147
Met Ser Met Ala Gln Val Gly Leu His Pro Ser Val Arg Pro Arg Pro 
                5                   10                  15      

Ser Ala Ala Lys Lys Thr Ala Tyr Ala Ala Asn Gln Ile Ala Val Asn 
            20                  25                  30          

Met Leu Trp Gln Ala Phe Asn Ala Val Ala Val Tyr Asp Tyr Val Ala 
        35                  40                  45              

Tyr His Gly Val Ser Ala Val Arg Leu Ser Ser Gly Leu Ile Val Tyr 
    50                  55                  60                  

Gly Val Leu Asn Ala Leu Phe Asn Leu Val Ala Gly His Val Ser Asp 
65                  70                  75                  80  

Arg Thr Lys Thr Arg Phe Gly Arg Arg Ile Pro Tyr Val Ala Val Ala 
                85                  90                  95      

Ser Ile Pro Tyr Ala Val Cys Phe Ala Leu Leu Phe Ser Pro Pro His 
            100                 105                 110         

Leu Ser Gln Thr Gly Leu Val Val Tyr Phe Leu Ala Met Thr Phe Leu 
        115                 120                 125             

Phe Asp Leu Ala Phe Thr Phe Thr Ala Leu Asn Ala Asn Ala Leu Tyr 
    130                 135                 140                 

Pro Glu Met Tyr Pro Asp Pro Arg Asp Arg Ala Tyr Val Ser Ala Leu 
145                 150                 155                 160 

Gln Gln Val Phe Gly Ile Val Gly Leu Ile Ala Gly Val Ala Leu Ser 
                165                 170                 175     

Lys Ser Leu Gly Gln Ala Leu Gly Trp Ser Arg Met Ala Trp Ile Phe 
            180                 185                 190         

Ala Ala Val Ala Val Ala Ser Met Tyr Val Ser Leu Trp Gly Ser Phe 
        195                 200                 205             

Glu Thr Gly Asp Pro Ala Glu Pro Phe Ala Trp Arg Glu Ala Leu Arg 
    210                 215                 220                 

Glu Thr Phe Arg Asn Arg Ala Phe Ile Trp Tyr Val Ile Ala Ser Phe 
225                 230                 235                 240 

Leu Val Gln Phe Thr Thr Thr Leu Phe Thr Thr Ala Ser Ser Phe Tyr 
                245                 250                 255     

Thr Ser Tyr Val Val Arg Leu Ser Pro Leu Gln Asn Ser Leu Phe Ile 
            260                 265                 270         

Gly Gly Ile Phe Val Val Ala Met Pro Ile Ala Phe Val Trp Ala Arg 
        275                 280                 285             

Ala Ala Ile Arg Tyr Gly Ala Ser Arg Ser Ala Met Val Ala Ile Ala 
    290                 295                 300                 

Leu Tyr Ala Cys Val Glu Ala Leu Leu Leu Val Asp Arg Ser Pro Thr 
305                 310                 315                 320 

Ser Val Leu Val Thr Gly Leu Cys Leu Gly Val Pro Val Ala Gly Phe 
                325                 330                 335     

Met Val Leu Leu Asn Met Leu Leu Ala Glu Val Ile Asp Leu Asp Ala 
            340                 345                 350         

Arg Arg Thr Gly Arg Arg Arg Glu Gly Met Tyr Leu Gly Met Asn Gly 
        355                 360                 365             

Cys Ile Val Arg Leu Gly Leu Ser Leu Gln Tyr Ala Val Met Ala Ile 
    370                 375                 380                 

Phe Phe Ala Val Ser Gly Tyr Arg Ala Gly Ala Ser Val Gln Pro Thr 
385                 390                 395                 400 

Ser Ala Val Glu Gly Leu Arg Leu Leu Leu Gly Leu Val Pro Ala Leu 
                405                 410                 415     

Phe Leu Ala Gly Ala Phe Leu Cys Met Arg Val Tyr Asp Arg Thr Arg 
            420                 425                 430         

Thr Arg 
        

<210>   148
<211>   434
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   148
Met Ser Met Ala Gln Val Gly Leu His Pro Ser Val Arg Pro Arg Pro 
                5                   10                  15      

Ser Ala Ala Lys Lys Thr Ala Tyr Ala Ala Asn Gln Ile Ala Val Asn 
            20                  25                  30          

Met Leu Trp Gln Ala Phe Asn Ala Val Ala Val Tyr Asp Tyr Val Ala 
        35                  40                  45              

Tyr His Gly Val Ser Ala Val Arg Leu Ser Ser Gly Leu Ile Val Tyr 
    50                  55                  60                  

Gly Val Leu Asn Ala Leu Phe Asn Leu Val Ala Gly His Val Ser Asp 
65                  70                  75                  80  

Arg Thr Lys Thr Arg Phe Gly Arg Arg Ile Pro Tyr Val Ala Val Ala 
                85                  90                  95      

Ser Ile Pro Tyr Ala Val Cys Phe Ala Leu Leu Phe Ser Pro Pro His 
            100                 105                 110         

Leu Ser Gln Thr Gly Leu Val Val Tyr Phe Leu Ala Met Thr Phe Leu 
        115                 120                 125             

Phe Asp Leu Ala Phe Thr Phe Thr Ala Leu Asn Ala Asn Ala Leu Tyr 
    130                 135                 140                 

Pro Glu Met Tyr Pro Asp Pro Arg Asp Arg Ala Tyr Val Ser Ala Leu 
145                 150                 155                 160 

Gln Gln Val Phe Gly Ile Val Gly Leu Ile Ala Gly Val Ala Leu Ser 
                165                 170                 175     

Lys Ser Ile Gly Gln Ala Leu Gly Trp Ser Arg Met Ala Trp Ile Phe 
            180                 185                 190         

Ala Ala Val Ala Val Ala Ser Met Tyr Val Ser Leu Trp Gly Ser Phe 
        195                 200                 205             

Glu Thr Gly Asp Pro Ala Glu Pro Phe Ala Trp Arg Glu Ala Leu Arg 
    210                 215                 220                 

Glu Thr Phe Arg Asn Arg Ala Phe Ile Trp Tyr Val Ile Ala Ser Phe 
225                 230                 235                 240 

Leu Val Gln Phe Thr Thr Thr Leu Phe Thr Thr Ala Ser Ser Phe Tyr 
                245                 250                 255     

Thr Ser Tyr Val Val Arg Leu Ser Pro Leu Gln Asn Ser Leu Phe Leu 
            260                 265                 270         

Gly Gly Ile Phe Val Val Ala Met Pro Ile Ala Phe Val Trp Ala Arg 
        275                 280                 285             

Ala Ala Ile Arg Tyr Gly Ala Ser Arg Ser Ala Met Val Ala Ile Ala 
    290                 295                 300                 

Leu Tyr Ala Cys Val Glu Ala Leu Leu Leu Val Asp Arg Ser Pro Thr 
305                 310                 315                 320 

Ser Val Leu Val Thr Gly Leu Cys Leu Gly Val Pro Val Ala Gly Phe 
                325                 330                 335     

Met Val Leu Leu Asn Met Leu Leu Ala Glu Val Ile Asp Leu Asp Ala 
            340                 345                 350         

Arg Arg Thr Gly Arg Arg Arg Glu Gly Met Tyr Leu Gly Met Asn Gly 
        355                 360                 365             

Cys Ile Val Arg Leu Gly Leu Ser Leu Gln Tyr Ala Val Met Ala Ile 
    370                 375                 380                 

Phe Phe Ala Val Ser Gly Tyr Arg Ala Gly Ala Ser Val Gln Pro Thr 
385                 390                 395                 400 

Ser Ala Val Glu Gly Leu Arg Leu Leu Leu Gly Leu Val Pro Ala Leu 
                405                 410                 415     

Phe Leu Ala Gly Ala Phe Leu Cys Met Arg Val Tyr Asp Arg Thr Arg 
            420                 425                 430         

Thr Arg 
        

<210>   149
<211>   1305
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   149
gtgtccatgg cgcaagttgg cctccatcct tctgttcggc cgcgcccgtc ggctgcgaaa       60

cgtaccgcat acgcagccaa tcaaatcgcc gtcaacatgc tttggcaggc gttcaacgcc      120

gtggcggtgt acgattacgt ggcctatcac ggcgtgtccg cggtccggct atcgagcggc      180

ctcatcgtct acggggtgct gaacgccttg ttcaacctcg tggcgggcca cgtgagcgac      240

cgcaccaaga cccgcttcgg ccggcgcatt ccgtacgtcg ccgtcgcatc catcccgtat      300

gccgtgtgtt tcgcgctttt gttctctccg ccacacctct cgcagaccgg cctcgtcgtg      360

tactttttgg ccatgacgtt cttgttcgat ctcgccttca ccttcacggc cctcaacgcg      420

aacgcgttgt acccggagat gtacccagat ccgcgcgatc gcgcgtacgt gtcggcgctt      480

cagcaggtct ttggcatcgt cgggctcatc gccggcgtcg ccttgtcgaa atcgcttggg      540

caggccctcg gctggtcgcg catggcctgg atcttcgccg cggtggccgt cgcgtcgatg      600

tacgtgtccc tctggggaag ctttgaaacg ggcgatcccg ccgaaccgtt cgcgtggcgg      660

gaggcgctgc gcgagacgtt ccgaaatcgc gcgttcattt ggtacgtgat cgcgagcttc      720

ctcgtccagt tcacgactac gctcttcacc acggcctcct cgttctacac gtcgtacgtg      780

gtgcgtctca gtccgctgca aaactcgctc tttctcggcg gaatcttcgt cgtcgcgatg      840

cccatcgcgt ttgtgtgggc tcgcgccgcg attcgatacg gcgcttcgcg gtcggccatg      900

gtcgccatcg cgctgtacgc gtgcgtcgag gcgctccttc tcgtcgatcg gtcgcccact      960

tccgtgctcg tgaccgggct ttgcctcggc gtccccgtcg cgggcttcat ggtcctcttg     1020

aacatgctct tggccgaggt gatcgatctc gacgcgcgcc gcacaggccg ccgccgcgaa     1080

gggatgtatc tgggcatgaa cgggtgcatc gtgcgactcg gcctatccct gcagtacgcc     1140

gtgatggcca tctttttcgc ggtctcgggc tatcgggcgg gcgccagcgt ccaaccgacg     1200

agtgcggtgg agggcttacg gctgttgctc ggcctcgtcc ctgcactctt tcttgcgggc     1260

gcgttcctgt gcatgcgggt gtacgaccga acgcgcacgc gatga                     1305


<210>   150
<211>   1305
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   150
gtgtccatgg cgcaagttgg cctccatcct tctgttcggc cgcgcccgtc ggctgcgaaa       60

aagaccgcat acgcagccaa tcaaatcgcc gtcaacatgc tttggcaggc gttcaacgcc      120

gtggcggtgt acgattacgt ggcctatcac ggcgtgtccg cggtccggct atcgagcggc      180

ctcatcgtct acggggtgct gaacgccttg ttcaacctcg tggcgggcca cgtgagcgac      240

cgcaccaaga cccgcttcgg ccggcgcatt ccgtacgtcg ccgtcgcatc catcccgtat      300

gccgtgtgtt tcgcgctttt gttctctccg ccacacctct cgcagaccgg cctcgtcgtg      360

tactttttgg ccatgacgtt cttgttcgat ctcgccttca ccttcacggc cctcaacgcg      420

aacgcgttgt acccggagat gtacccagat ccgcgcgatc gcgcgtacgt gtcggcgctt      480

cagcaggtct ttggcatcgt cgggctcatc gccggcgtcg ccttgtcgaa atcgcttggg      540

caggccctcg gctggtcgcg catggcctgg atcttcgccg cggtggccgt cgcgtcgatg      600

tacgtgtccc tctggggaag ctttgaaacg ggcgatcccg ccgaaccgtt cgcgtggcgg      660

gaggcgctgc gcgagacgtt ccgaaatcgc gcgttcattt ggtacgtgat cgcgagcttc      720

ctcgtccagt tcacgactac gctcttcacc acggcctcct cgttctacac gtcgtacgtg      780

gtgcgtctca gtccgctgca aaactcgctc tttctcggcg gaatcttcgt cgtcgcgatg      840

cccatcgcgt ttgtgtgggc tcgcgccgcg attcgatacg gcgcttcgcg gtcggccatg      900

gtcgccatcg cgctgtacgc gtgcgtcgag gcgctccttc tcgtcgatcg gtcgcccact      960

tccgtgctcg tgaccgggct ttgcctcggc gtccccgtcg cgggcttcat ggtcctcttg     1020

aacatgctct tggccgaggt gatcgatctc gacgcgcgcc gcacaggccg ccgccgcgaa     1080

gggatgtatc tgggcatgaa cgggtgcatc gtgcgactcg gcctatccct gcagtacgcc     1140

gtgatggcca tctttttcgc ggtctcgggc tatcgggcgg gcgccagcgt ccaaccgacg     1200

agtgcggtgg agggcattcg gctgttgctc ggcctcgtcc ctgcactctt tcttgcgggc     1260

gcgttcctgt gcatgcgggt gtacgaccga acgcgcacgc gatga                     1305


<210>   151
<211>   1305
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   151
gtgtccatgg cgcaagttgg cctccatcct tctgttcggc cgcgcccgtc ggctgcgaaa       60

aagaccgcat acgcagccaa tcaaatcgcc gtcaacatgc tttggcaggc gttcaacgcc      120

gtggcggtgt acgattacgt ggcctatcac ggcgtgtccg cggtccggct atcgagcggc      180

ctcatcgtct acggggtgct gaacgccttg ttcaacctcg tggcgggcca cgtgagcgac      240

cgcaccaaga cccgcttcgg ccggcgcatt ccgtacgtcg ccgtcgcatc catcccgtat      300

gccgtgtgtt tcgcgctttt gttctctccg ccacacctct cgcagaccgg cctcgtcgtg      360

tactttttgg ccatgacgtt cttgttcgat ctcgccttca ccttcacggc cctcaacgcg      420

aacgcgttgt acccggagat gtacccagat ccgcgcgatc gcgcgtacat ttcggcgctt      480

cagcaggtct ttggcatcgt cgggctcatc gccggcgtcg ccttgtcgaa atcgcttggg      540

caggccctcg gctggtcgcg catggcctgg atcttcgccg cggtggccgt cgcgtcgatg      600

tacgtgtccc tctggggaag ctttgaaacg ggcgatcccg ccgaaccgtt cgcgtggcgg      660

gaggcgctgc gcgagacgtt ccgaaatcgc gcgttcattt ggtacgtgat cgcgagcttc      720

ctcgtccagt tcacgactac gctcttcacc acggcctcct cgttctacac gtcgtacgtg      780

gtgcgtctca gtccgctgca aaactcgctc tttctcggcg gaatcttcgt cgtcgcgatg      840

cccatcgcgt ttgtgtgggc tcgcgccgcg attcgatacg gcgcttcgcg gtcggccatg      900

gtcgccatcg cgctgtacgc gtgcgtcgag gcgctccttc tcgtcgatcg gtcgcccact      960

tccgtgctcg tgaccgggct ttgcctcggc gtccccgtcg cgggcttcat ggtcctcttg     1020

aacatgctct tggccgaggt gatcgatctc gacgcgcgcc gcacaggccg ccgccgcgaa     1080

gggatgtatc tgggcatgaa cgggtgcatc gtgcgactcg gcctatccct gcagtacgcc     1140

gtgatggcca tctttttcgc ggtctcgggc tatcgggcgg gcgccagcgt ccaaccgacg     1200

agtgcggtgg agggcttacg gctgttgctc ggcctcgtcc ctgcactctt tcttgcgggc     1260

gcgttcctgt gcatgcgggt gtacgaccga acgcgcacgc gatga                     1305


<210>   152
<211>   1305
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   152
gtgtccatgg cgcaagttgg cctccatcct tctgttcggc cgcgcccgtc ggctgcgaaa       60

aagaccgcat acgcagccaa tcaaatcgcc gtcaacatgc tttggcaggc gttcaacgcc      120

gtggcggtgt acgattacgt ggcctatcac ggcgtgtccg cggtccggct atcgagcggc      180

ctcatcgtct acggggtgct gaacgccttg ttcaacctcg tggcgggcca cgtgagcgac      240

cgcaccaaga cccgcttcgg ccggcgcatt ccgtacgtcg ccgtcgcatc catcccgtat      300

gccgtgtgtt tcgcgctttt gttctctccg ccacacctct cgcagaccgg cctcgtcgtg      360

tactttttgg ccatgacgtt cttgttcgat ctcgccttca ccttcacggc cctcaacgcg      420

aacgcgttgt acccggagat gtacccagat ccgcgcgatc gcgcgtacgt gtcggcgctt      480

cagcaggtct ttggcatcgt cgggctcatc gccggcgtcg ccttgtcgaa atcgcttggg      540

caggccctcg gctggtcgcg catggcctgg atcttcgccg cggtggccgt cgcgtcgatg      600

tacgtgtccc tctggggaag ctttgaaacg ggcgatcccg ccgaaccgtt cgcgtggcgg      660

gaggcgctgc gcgagacgtt ccgaaatcgc gcgttcattt ggtacgtgat cgcgagcttc      720

ctcgtccagt tcacgactac gctcttcacc acggcctcct cgttctacac gtcgtacgtg      780

gtgcgtctca gtccgctgca aaactcgctc tttattggcg gaatcttcgt cgtcgcgatg      840

cccatcgcgt ttgtgtgggc tcgcgccgcg attcgatacg gcgcttcgcg gtcggccatg      900

gtcgccatcg cgctgtacgc gtgcgtcgag gcgctccttc tcgtcgatcg gtcgcccact      960

tccgtgctcg tgaccgggct ttgcctcggc gtccccgtcg cgggcttcat ggtcctcttg     1020

aacatgctct tggccgaggt gatcgatctc gacgcgcgcc gcacaggccg ccgccgcgaa     1080

gggatgtatc tgggcatgaa cgggtgcatc gtgcgactcg gcctatccct gcagtacgcc     1140

gtgatggcca tctttttcgc ggtctcgggc tatcgggcgg gcgccagcgt ccaaccgacg     1200

agtgcggtgg agggcttacg gctgttgctc ggcctcgtcc ctgcactctt tcttgcgggc     1260

gcgttcctgt gcatgcgggt gtacgaccga acgcgcacgc gatga                     1305


<210>   153
<211>   1305
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   153
gtgtccatgg cgcaagttgg cctccatcct tctgttcggc cgcgcccgtc ggctgcgaaa       60

aagaccgcat acgcagccaa tcaaatcgcc gtcaacatgc tttggcaggc gttcaacgcc      120

gtggcggtgt acgattacgt ggcctatcac ggcgtgtccg cggtccggct atcgagcggc      180

ctcatcgtct acggggtgct gaacgccttg ttcaacctcg tggcgggcca cgtgagcgac      240

cgcaccaaga cccgcttcgg ccggcgcatt ccgtacgtcg ccgtcgcatc catcccgtat      300

gccgtgtgtt tcgcgctttt gttctctccg ccacacctct cgcagaccgg cctcgtcgtg      360

tactttttgg ccatgacgtt cttgttcgat ctcgccttca ccttcacggc cctcaacgcg      420

aacgcgttgt acccggagat gtacccagat ccgcgcgatc gcgcgtacgt gtcggcgctt      480

cagcaggtct ttggcatcgt cgggctcatc gccggcgtcg ccttgtcgaa atcgattggg      540

caggccctcg gctggtcgcg catggcctgg atcttcgccg cggtggccgt cgcgtcgatg      600

tacgtgtccc tctggggaag ctttgaaacg ggcgatcccg ccgaaccgtt cgcgtggcgg      660

gaggcgctgc gcgagacgtt ccgaaatcgc gcgttcattt ggtacgtgat cgcgagcttc      720

ctcgtccagt tcacgactac gctcttcacc acggcctcct cgttctacac gtcgtacgtg      780

gtgcgtctca gtccgctgca aaactcgctc tttctcggcg gaatcttcgt cgtcgcgatg      840

cccatcgcgt ttgtgtgggc tcgcgccgcg attcgatacg gcgcttcgcg gtcggccatg      900

gtcgccatcg cgctgtacgc gtgcgtcgag gcgctccttc tcgtcgatcg gtcgcccact      960

tccgtgctcg tgaccgggct ttgcctcggc gtccccgtcg cgggcttcat ggtcctcttg     1020

aacatgctct tggccgaggt gatcgatctc gacgcgcgcc gcacaggccg ccgccgcgaa     1080

gggatgtatc tgggcatgaa cgggtgcatc gtgcgactcg gcctatccct gcagtacgcc     1140

gtgatggcca tctttttcgc ggtctcgggc tatcgggcgg gcgccagcgt ccaaccgacg     1200

agtgcggtgg agggcttacg gctgttgctc ggcctcgtcc ctgcactctt tcttgcgggc     1260

gcgttcctgt gcatgcgggt gtacgaccga acgcgcacgc gatga                     1305


<210>   154
<211>   438
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   154
Met Lys His Lys Asn Lys Ala Leu Met Ala Thr Ala Thr Ala Val Val 
                5                   10                  15      

Met Cys Ala Trp Met Ala Thr Gly Cys Gly Asp Glu Glu Thr Gly Gly 
            20                  25                  30          

Gly Gly Gly Ile Pro Met Thr Lys Ser Ser Asn Ala Ser Gly Gln Ala 
        35                  40                  45              

Ala Ser Thr Ala Gln Pro Val Thr Ile Thr Phe Glu Glu Ser Met Pro 
    50                  55                  60                  

Gly Lys Leu Gly Thr Glu Leu Gln Lys Leu Thr Asn Glu Phe Glu Lys 
65                  70                  75                  80  

Gln Asn Pro Asn Ile His Val Gln Leu Ile Phe Asn Gly Ser Tyr Ser 
                85                  90                  95      

Thr Leu Glu Gln Lys Leu Thr Ala Ala Ile Ala Ser Gly Thr Glu Pro 
            100                 105                 110         

Thr Val Ala Gln Val Glu Glu Thr Trp Glu Thr Asn Tyr Val Gln Asn 
        115                 120                 125             

Gly Leu Ile Glu Pro Leu Asp Ser Val Ile Pro Lys Ser Thr Gln Asn 
    130                 135                 140                 

Asp Leu Ile Pro Ile Trp Arg Gln Asp Ser Thr Tyr Asn Gly Lys Leu 
145                 150                 155                 160 

Met Ser Val Pro Phe Asn Lys Ser Ala Tyr Val Leu Tyr Tyr Asn Val 
                165                 170                 175     

Asp Asp Leu Lys Lys Ala Gly Ile Ser Ser Pro Pro Thr Thr Trp Ser 
            180                 185                 190         

Gln Leu Glu Gln Asp Ala Ile Lys Ile Gln Lys Lys Glu Gly Ile Pro 
        195                 200                 205             

Gly Leu Gly Leu Gln Gly Asn Tyr Tyr Thr Phe Glu Met Leu Leu Lys 
    210                 215                 220                 

Gln Ala Gly Gly Gln Ile Leu Asn Ala Arg Asn Thr Lys Ala Ala Phe 
225                 230                 235                 240 

Asp Ser Ser Ala Gly Leu Ala Ala Leu His Phe Met Lys Arg Leu Val 
                245                 250                 255     

Asp Glu His Ala Ala Lys Val Ile Gly Ala Asn Glu Tyr Leu Ser Asp 
            260                 265                 270         

Gly Phe Asn Thr Asn Glu Tyr Ala Met Asp Leu Asp Thr Val Ala Ala 
        275                 280                 285             

Met Ser Phe Ile Asn Asn Ser Asn Leu His Trp Lys Val Ala Pro Leu 
    290                 295                 300                 

Pro Lys Gly Val Thr Tyr Ala Val Pro Thr Ala Gly Leu Asn Leu Val 
305                 310                 315                 320 

Ile Phe Asn Ala Ala Thr Ser Ala Gln Lys Ala Ala Ala Ala Lys Tyr 
                325                 330                 335     

Leu Asn Phe Leu Ile Ser Val Pro Ser Thr Ile Glu Trp Ala Glu Gln 
            340                 345                 350         

Thr Gly Tyr Leu Pro Val Arg Gln Ser Ala Leu Thr Asn Ser Ala Trp 
        355                 360                 365             

Thr Ser Phe Ile Lys Thr His Pro Asn Gln Gly Val Ala Pro Asn Glu 
    370                 375                 380                 

Leu Lys Tyr Ala Tyr Phe Ser Pro Arg Leu Ala Ser Leu Tyr Ser Ala 
385                 390                 395                 400 

Glu Gln Glu Met Thr Thr Gln Ile Gly Asn Met Leu Ala Gly Arg Gln 
                405                 410                 415     

Thr Pro Gln Val Thr Leu Gln Asn Met Ala Asn Ile Thr Asn Gln Ala 
            420                 425                 430         

Leu Ala Gln Gly Asn Ser 
        435             

<210>   155
<211>   1317
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   155
gtgaaacaca aaaacaaggc cctcatggcg acagccacag cggtggtgat gtgcgcgtgg       60

atggccactg gatgcggaga cgaggagacc ggcggcgggg gcggaatccc catgaccaag      120

tcctccaacg catcgggaca agccgcgagc accgcgcaac ctgtgaccat cacctttgag      180

gaatccatgc ctggcaagct cgggaccgaa ctccaaaagc tgacgaacga gtttgagaag      240

caaaatccca acatccacgt gcagctcatc ttcaatggct cgtacagcac gttggagcag      300

aagttgaccg ccgccattgc gtccggcaca gagcccacgg tggcgcaggt cgaggagacg      360

tgggagacga attacgtgca gaacggtctg attgagcccc tcgactccgt cattccgaaa      420

tccacgcaga acgatctaat cccgatttgg cgtcaggact cgacgtacaa cggcaagttg      480

atgtccgttc ccttcaacaa gtccgcctac gtcctgtact acaatgtgga cgatttaaag      540

aaggccggga tttcttcgcc gccgacaacc tggagccagc tcgaacagga tgccatcaag      600

attcaaaaga aagaaggcat tccgggcctc ggcctgcagg gcaactatta cacctttgaa      660

atgctcttaa aacaagcggg tggacagatc ctgaacgcca gaaacaccaa ggcggccttc      720

gatagctcag ccggtctcgc agcgctccat ttcatgaagc gcttggtgga tgaacacgcg      780

gccaaggtca tcggcgcgaa cgaatacctc tccgacggtt tcaacacgaa cgagtacgcg      840

atggacctcg acacggtcgc cgcgatgtcg ttcatcaaca actcgaacct ccattggaaa      900

gttgcgccgc tcccaaaggg cgtgacctac gccgtcccca cggccggttt gaacttggtc      960

attttcaacg cagcgacatc cgctcagaaa gcggcggcgg cgaagtatct gaacttcctc     1020

atttctgtac catcgaccat cgagtgggcg gaacagacag gctacctccc cgtccgccaa     1080

agcgcactca ccaattcggc ctggacgagc ttcatcaaga cccatccgaa tcagggggtc     1140

gcacccaacg agctgaaata cgcctatttc tcccctcggc tcgcttcgct ctactccgcg     1200

gagcaagaga tgaccacaca gattggcaac atgctggcgg gtcggcagac gccgcaggtg     1260

accctgcaga acatggcgaa catcacgaac caagcgctcg cccagggcaa ttcatga        1317


<210>   156
<211>   392
<212>   PRT
<213>   Thermotoga sp. RQ2

<400>   156
Val Lys Val Thr Phe Trp His Ala Met Gly Gly Gly His Gly Glu Thr 
                5                   10                  15      

Leu Gln Glu Ile Val Asn Thr Phe Asn Glu Leu His Pro Asp Ile Glu 
            20                  25                  30          

Val Glu Ala Val Tyr Val Gly Asn Tyr Ser Ala Leu Ser Gln Lys Leu 
        35                  40                  45              

Leu Ala Ala Ala Gln Ala Gly Glu Leu Pro Thr Ile Ser Gln Ser Tyr 
    50                  55                  60                  

Ser Asn Trp Thr Ala Lys Leu Ile Gln Ser Gly Val Val Gln Pro Leu 
65                  70                  75                  80  

Asn Glu Phe Val Asn Asp Pro Lys Ile Gly Leu Thr Lys Glu Glu Trp 
                85                  90                  95      

Glu Asp Ile Phe Lys Pro Leu Arg Asp Asn Cys Met Trp Gly Asp Thr 
            100                 105                 110         

Ile Tyr Ala Val Pro Phe Asn Lys Ser Leu Tyr Ile Leu Tyr Tyr Asn 
        115                 120                 125             

Ala Asp Ala Phe Ala Met Tyr Gly Val Asp Val Pro Lys Thr Ile Asp 
    130                 135                 140                 

Glu Leu Tyr Glu Ala Ala Arg Ile Met Thr Glu Asp Leu Asp Gly Asp 
145                 150                 155                 160 

Gly Asn Ile Asp Gln Tyr Gly Phe Gly Phe Arg Thr Thr Val Asp Phe 
                165                 170                 175     

Phe Gln Ile Leu Leu Leu Leu Arg Gly Gly Ser Ile Leu Lys Gln Val 
            180                 185                 190         

Asp Gly Lys Trp Val Ser Asn Ile Asp Ser Gln Glu Thr Arg Asp Val 
        195                 200                 205             

Leu Ala Phe Val Lys Lys Met Val Asp Asp Gly Ile Ala Tyr Phe Gln 
    210                 215                 220                 

Gly Gly Tyr Leu Asn Asp Ile Phe Gly Gln Gln Lys Ile Met Met Tyr 
225                 230                 235                 240 

Ile Asp Thr Ile Ala Gly Arg Pro Tyr Val Glu Ser Ser Thr Lys Gly 
                245                 250                 255     

Lys Phe Thr Trp Ser Trp Ala Pro Val Pro Thr Trp Val Thr Asn Lys 
            260                 265                 270         

Val Pro Phe Ala Gly Thr Asp Ile Ile Met Phe Asn Thr Ala Ser Asp 
        275                 280                 285             

Glu Glu Lys Arg Ala Ala Trp Glu Phe Met Lys Tyr Leu Ile Ser Pro 
    290                 295                 300                 

Glu Val Thr Ala Tyr Trp Ala Ile Asn Thr Gly Tyr Ile Pro Val Arg 
305                 310                 315                 320 

Arg Ser Ala Leu Glu Thr Ser Ile Trp Lys Glu Ala Ala Lys Ser Asp 
                325                 330                 335     

Pro Leu Ile Glu Ile Pro Leu Lys Gln Ile Asp Asn Ala Met Phe Asp 
            340                 345                 350         

Pro Gln Ile Gly Val Trp Tyr Glu Ile Arg Thr Val Val Gly Asn Met 
        355                 360                 365             

Phe Ser Asp Phe Ile Asn Gly Lys Val Asp Met Glu Thr Ala Ile Lys 
    370                 375                 380                 

Thr Ala Asp Gln Lys Ile Arg Glu 
385                 390         

<210>   157
<211>   392
<212>   PRT
<213>   Thermotoga petrophila RKU-1

<400>   157
Val Lys Val Thr Phe Trp His Ala Met Gly Gly Gly His Gly Lys Thr 
                5                   10                  15      

Leu Gln Glu Ile Val Asn Thr Phe Asn Glu Leu His Pro Asp Ile Glu 
            20                  25                  30          

Val Glu Ala Val Tyr Val Gly Asn Tyr Gly Ala Leu Ser Gln Lys Leu 
        35                  40                  45              

Leu Ala Ala Ala Gln Ala Gly Glu Leu Pro Thr Ile Ala Gln Ser Tyr 
    50                  55                  60                  

Ser Asn Trp Thr Ala Lys Leu Ile Gln Ser Gly Val Val Gln Pro Leu 
65                  70                  75                  80  

Asn Glu Phe Val Asn Asp Pro Lys Ile Gly Leu Thr Arg Glu Glu Trp 
                85                  90                  95      

Glu Asp Val Phe Lys Pro Leu Arg Asp Asn Cys Met Trp Gly Asp Thr 
            100                 105                 110         

Val Tyr Ala Val Pro Phe Asn Lys Ser Leu Tyr Ile Leu Tyr Tyr Asn 
        115                 120                 125             

Ala Asp Ala Phe Ala Met Tyr Gly Val Asp Val Pro Lys Thr Ile Asp 
    130                 135                 140                 

Glu Leu Tyr Glu Ala Ala Arg Ile Met Thr Glu Asp Leu Asp Gly Asp 
145                 150                 155                 160 

Gly Lys Ile Asp Gln Tyr Gly Phe Gly Phe Arg Thr Thr Val Asp Phe 
                165                 170                 175     

Phe Gln Ile Leu Leu Ile Leu Arg Gly Gly Ser Ile Leu Lys Gln Val 
            180                 185                 190         

Asp Gly Lys Trp Val Ser Asn Ile Asp Ser Gln Glu Thr Arg Glu Val 
        195                 200                 205             

Leu Ala Phe Val Lys Lys Met Val Asp Asp Gly Ile Ala Tyr Phe Gln 
    210                 215                 220                 

Gly Gly Tyr Leu Asn Asp Ile Phe Gly Gln Gln Lys Ile Met Met Tyr 
225                 230                 235                 240 

Ile Asp Thr Ile Ala Gly Arg Pro Tyr Val Glu Ser Ser Thr Lys Gly 
                245                 250                 255     

Lys Phe Thr Trp Ser Trp Ala Pro Val Pro Thr Trp Val Thr Asn Lys 
            260                 265                 270         

Val Pro Phe Ala Gly Thr Asp Ile Ile Met Phe Asn Thr Ala Ser Asp 
        275                 280                 285             

Glu Glu Lys Arg Ala Ala Trp Glu Phe Met Lys Tyr Leu Ile Ser Pro 
    290                 295                 300                 

Glu Val Thr Ala Tyr Trp Ala Ile Asn Thr Gly Tyr Ile Pro Val Arg 
305                 310                 315                 320 

Arg Ser Ala Leu Glu Thr Ser Ile Trp Lys Glu Ala Ala Lys Ser Asp 
                325                 330                 335     

Pro Leu Ile Glu Ile Pro Leu Lys Gln Ile Asp Asn Ala Val Phe Asp 
            340                 345                 350         

Pro Gln Ile Gly Val Trp Tyr Glu Ile Arg Thr Val Val Gly Asn Met 
        355                 360                 365             

Phe Ser Asp Phe Ile Asn Gly Lys Val Asp Met Glu Thr Ala Ile Lys 
    370                 375                 380                 

Thr Ala Asp Gln Lys Ile Arg Glu 
385                 390         

<210>   158
<211>   413
<212>   PRT
<213>   Clostridium botulinum F str. Langeland

<400>   158
Lys Glu Glu Ser Lys Ala Thr Ile Ala Thr Glu Ile Lys Glu Pro Val 
                5                   10                  15      

Thr Ile Glu Phe Trp His Ala Met Ser Gly Asp Asn Glu Ala Ala Leu 
            20                  25                  30          

Lys Glu Ile Thr Glu Glu Phe Asn Lys Lys Asn Lys Asp Lys Ile Thr 
        35                  40                  45              

Val Lys Leu Val Tyr Gln Gly Gln Tyr Lys Glu Leu Phe Ser Lys Leu 
    50                  55                  60                  

Asp Gly Ala Ala Lys Ser Lys Lys Leu Pro Ala Leu Thr Met Ile Tyr 
65                  70                  75                  80  

Pro Asn Arg Leu Thr Ala Tyr Val Met Asn Asp Leu Val Glu Asn Leu 
                85                  90                  95      

Asn Pro Tyr Ile Glu Asn Glu Lys Ile Gly Phe Lys Lys Asp Val Trp 
            100                 105                 110         

Asp Asp Ile Pro Glu Phe Val Arg Asp Asn Gly Met Trp Asn Asp Lys 
        115                 120                 125             

His Tyr Ser Leu Pro Phe Asn Lys Gly Thr Tyr Leu Leu Phe Tyr Asn 
    130                 135                 140                 

Glu Asp Leu Leu Lys Lys Tyr Asn Val Lys Val Pro Asn Asn Trp Asn 
145                 150                 155                 160 

Glu Leu Lys Glu Ala Ser Lys Lys Leu Thr Val Asp Thr Asn Gly Asp 
                165                 170                 175     

Gly Lys Asn Asp Ile Tyr Gly Leu Gly Leu Asn Ser Ser Val Gly Ile 
            180                 185                 190         

Asp Ser Ser Phe Trp Val Glu Gln Ala Gly Gly His Leu Ile Asp Glu 
        195                 200                 205             

Ala Asn Asp Lys Leu Leu Phe Asn Ser Lys Glu Gly Val Glu Ala Phe 
    210                 215                 220                 

Asp Phe Leu Ser Glu Leu Val Lys Ser Gly Asn Ala Lys Ile Ser Thr 
225                 230                 235                 240 

Glu Glu Lys Tyr Met Thr Gly Ala Phe Ser Arg Gly Glu Ala Ala Met 
                245                 250                 255     

Gly Ile Ser Ser Ile Ser Ala Leu Pro Asp Ile Ile Lys Ala Cys Lys 
            260                 265                 270         

Gly Asn Asn Ile Asn Phe Lys Thr Ala Val Leu Pro Glu Gly Lys Lys 
        275                 280                 285             

Lys Ala Ala Leu Phe Ser Gly Thr Asp Val Ala Ile Phe Asn Thr Pro 
    290                 295                 300                 

Ser Pro Glu Glu Lys Leu Ala Ala Phe Glu Tyr Leu Lys Phe Phe Met 
305                 310                 315                 320 

Glu Lys Glu Ser Gln Thr Arg Trp Ala Thr Lys Ser Gly Tyr Leu Pro 
                325                 330                 335     

Leu Arg Lys Ser Val Ile Asp Ser Lys Glu Phe Lys Asp Tyr Val Glu 
            340                 345                 350         

Lys Glu Asn Pro Ala Lys Gly Glu Ala Val Lys Glu Phe Asp Tyr Gly 
        355                 360                 365             

Tyr Cys Asp Pro Lys Val Leu Asn Gly Tyr Ala Ile His Asp Asn Met 
    370                 375                 380                 

Ala Lys Ala Leu Asp Gln Ile Ile Ala Gly Lys Lys Asp Ser Lys Gln 
385                 390                 395                 400 

Ala Leu Ser Asp Ala Glu Lys Lys Ala Arg Gln Glu Leu 
                405                 410             

<210>   159
<211>   413
<212>   PRT
<213>   Clostridium botulinum A str. ATCC 3502

<400>   159
Lys Glu Glu Ser Lys Ala Thr Ile Ala Thr Glu Ile Lys Glu Pro Val 
                5                   10                  15      

Thr Ile Glu Phe Trp His Ala Met Asn Gly Asp Asn Glu Ala Ala Leu 
            20                  25                  30          

Lys Glu Ile Thr Glu Glu Phe Asn Lys Lys Asn Lys Asp Lys Ile Thr 
        35                  40                  45              

Val Lys Leu Val Tyr Gln Gly Gln Tyr Lys Glu Leu Phe Ser Lys Leu 
    50                  55                  60                  

Asp Gly Ala Ala Lys Ser Lys Lys Leu Pro Ala Leu Thr Met Ile Tyr 
65                  70                  75                  80  

Pro Asn Arg Leu Thr Ala Tyr Val Met Asn Asp Leu Val Glu Asn Leu 
                85                  90                  95      

Asn Pro Tyr Ile Glu Asn Glu Lys Ile Gly Phe Lys Lys Asp Val Trp 
            100                 105                 110         

Asp Asp Ile Pro Glu Phe Val Arg Asp Asn Gly Met Trp Asn Asp Lys 
        115                 120                 125             

His Tyr Ser Leu Pro Phe Asn Lys Gly Thr Tyr Leu Leu Phe Tyr Asn 
    130                 135                 140                 

Glu Asp Leu Leu Lys Lys Tyr Asn Val Lys Val Pro Asn Asn Trp Asn 
145                 150                 155                 160 

Glu Leu Lys Glu Ala Ser Lys Lys Leu Thr Val Asp Thr Asn Gly Asp 
                165                 170                 175     

Gly Lys Asn Asp Ile Tyr Gly Leu Gly Leu Asn Ser Ser Val Gly Ile 
            180                 185                 190         

Asp Ser Ser Phe Trp Val Glu Gln Ala Gly Gly His Leu Ile Asp Glu 
        195                 200                 205             

Ala Asn Asp Lys Leu Leu Phe Asn Ser Lys Glu Gly Ala Glu Ala Phe 
    210                 215                 220                 

Asp Phe Leu Ser Glu Leu Val Lys Ser Gly Asn Ala Lys Ile Ser Thr 
225                 230                 235                 240 

Glu Glu Lys Tyr Met Thr Gly Ala Phe Ser Arg Gly Glu Ala Ala Met 
                245                 250                 255     

Gly Ile Ser Ser Ile Ser Ala Leu Pro Asp Ile Ile Lys Ala Cys Lys 
            260                 265                 270         

Gly Asn Asn Ile Asn Phe Lys Thr Ala Val Leu Pro Glu Gly Lys Lys 
        275                 280                 285             

Lys Ala Ala Leu Phe Ser Gly Thr Asp Val Ala Ile Phe Asn Thr Pro 
    290                 295                 300                 

Ser Pro Glu Glu Lys Leu Ala Ala Phe Glu Tyr Leu Lys Phe Phe Met 
305                 310                 315                 320 

Glu Lys Glu Ser Gln Thr Lys Trp Ala Thr Lys Ser Gly Tyr Leu Pro 
                325                 330                 335     

Leu Arg Lys Ser Val Ile Asp Ser Lys Glu Phe Lys Asp Tyr Val Glu 
            340                 345                 350         

Lys Glu Asn Pro Ala Lys Gly Glu Ala Val Lys Glu Phe Asp Tyr Gly 
        355                 360                 365             

Tyr Cys Asp Pro Lys Val Leu Asn Gly Tyr Ala Ile His Asp Asn Met 
    370                 375                 380                 

Ala Lys Ala Leu Asp Gln Ile Ile Ala Gly Lys Lys Asp Ser Lys Gln 
385                 390                 395                 400 

Ala Leu Ser Asp Ala Glu Lys Lys Ala Arg Gln Glu Leu 
                405                 410             

<210>   160
<211>   392
<212>   PRT
<213>   Thermotoga maritima MSB8

<400>   160
Val Lys Val Thr Phe Trp His Ala Met Gly Gly Gly His Gly Lys Thr 
                5                   10                  15      

Leu Gln Glu Ile Val Asn Thr Phe Asn Glu Leu His Pro Asp Ile Glu 
            20                  25                  30          

Val Glu Ala Val Tyr Val Gly Asn Tyr Gly Ala Leu Ser Gln Lys Leu 
        35                  40                  45              

Leu Ala Ala Ala Gln Ala Gly Glu Leu Pro Thr Ile Ser Gln Ala Tyr 
    50                  55                  60                  

Ser Asn Trp Thr Ala Lys Leu Ile Gln Ser Gly Val Val Gln Pro Leu 
65                  70                  75                  80  

Asn Glu Phe Val Asn Asp Pro Lys Ile Gly Leu Thr Lys Glu Glu Trp 
                85                  90                  95      

Glu Asp Ile Phe Lys Pro Leu Arg Asp Asn Cys Met Trp Gly Asp Thr 
            100                 105                 110         

Ile Tyr Ala Val Pro Phe Asn Lys Ser Leu Tyr Val Leu Tyr Tyr Asn 
        115                 120                 125             

Ala Asp Ala Phe Ala Met Tyr Gly Val Asp Val Pro Lys Thr Ile Asp 
    130                 135                 140                 

Glu Leu Tyr Glu Ala Ala Arg Ile Met Thr Glu Asp Phe Asp Gly Asp 
145                 150                 155                 160 

Gly Lys Ile Asp Gln Tyr Gly Phe Gly Phe Arg Thr Thr Val Asp Phe 
                165                 170                 175     

Phe Gln Ile Leu Leu Thr Leu Arg Gly Gly Ser Ile Leu Lys Gln Val 
            180                 185                 190         

Asp Gly Lys Trp Val Ser Asn Ile Asp Ser Gln Glu Thr Arg Asp Val 
        195                 200                 205             

Leu Ala Phe Val Lys Lys Met Val Asp Asp Gly Ile Ala Tyr Ser Gln 
    210                 215                 220                 

Gly Gly Tyr Leu Asp Gly Ile Phe Gly Gln Gln Lys Ile Met Met Tyr 
225                 230                 235                 240 

Ile Ser Thr Ile Ala Gly Arg Pro Tyr Val Glu Lys Ser Thr Lys Gly 
                245                 250                 255     

Lys Phe Thr Trp Ser Trp Ala Pro Val Pro Thr Trp Val Thr Asn Lys 
            260                 265                 270         

Val Pro Phe Ala Gly Thr Asp Ile Ile Met Phe Asn Thr Ala Ser Glu 
        275                 280                 285             

Glu Glu Lys Lys Ala Ala Trp Glu Phe Met Lys Tyr Leu Ile Ser Pro 
    290                 295                 300                 

Glu Val Thr Ala Tyr Trp Ala Ile Asn Thr Gly Tyr Ile Pro Val Arg 
305                 310                 315                 320 

Arg Ser Ala Leu Glu Thr Ser Ile Trp Lys Glu Ala Ala Lys Ser Asp 
                325                 330                 335     

Pro Leu Leu Glu Ile Pro Leu Lys Gln Ile Asp Asn Ala Val Phe Asp 
            340                 345                 350         

Pro Gln Ile Gly Val Trp Tyr Glu Ile Arg Thr Val Val Gly Asn Met 
        355                 360                 365             

Phe Ser Asp Phe Ile Asn Gly Lys Val Asp Met Glu Thr Ala Ile Lys 
    370                 375                 380                 

Thr Ala Asp Gln Lys Ile Arg Glu 
385                 390         

<210>   161
<211>   438
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   161
Met Lys His Lys Asn Lys Ala Leu Met Ala Thr Ala Thr Ala Val Val 
                5                   10                  15      

Met Cys Ala Trp Met Ala Thr Gly Cys Gly Asp Glu Glu Thr Gly Gly 
            20                  25                  30          

Gly Gly Gly Ile Pro Met Thr Lys Ser Ser Asn Ala Ser Gly Gln Ala 
        35                  40                  45              

Ala Ser Thr Ala Gln Pro Val Thr Ile Thr Phe Glu Glu Ser Met Pro 
    50                  55                  60                  

Gly Lys Leu Gly Thr Glu Leu Gln Lys Leu Thr Asn Glu Phe Glu Lys 
65                  70                  75                  80  

Gln Asn Pro Asn Ile His Val Gln Leu Ile Phe Asn Gly Ser Tyr Ser 
                85                  90                  95      

Thr Leu Glu Gln Lys Leu Thr Ala Ala Ile Ala Ser Gly Thr Glu Pro 
            100                 105                 110         

Thr Val Ala Gln Val Glu Glu Thr Trp Glu Thr Asn Tyr Val Gln Asn 
        115                 120                 125             

Gly Leu Ile Glu Pro Leu Asp Ser Val Ile Pro Lys Ser Thr Gln Asn 
    130                 135                 140                 

Asp Leu Ile Pro Ile Trp Arg Gln Asp Ser Thr Tyr Asn Gly Arg Leu 
145                 150                 155                 160 

Met Ser Val Pro Phe Asn Lys Ser Ala Tyr Val Leu Tyr Tyr Asn Val 
                165                 170                 175     

Asp Asp Leu Lys Lys Ala Gly Ile Ser Ser Pro Pro Thr Thr Trp Ser 
            180                 185                 190         

Gln Leu Glu Gln Asp Ala Ile Lys Ile Gln Lys Lys Glu Gly Ile Pro 
        195                 200                 205             

Gly Leu Gly Leu Gln Gly Asn Tyr Tyr Thr Phe Glu Met Leu Leu Lys 
    210                 215                 220                 

Gln Ala Gly Gly Gln Ile Leu Asn Ala Arg Asn Thr Lys Ala Ala Phe 
225                 230                 235                 240 

Asp Ser Ser Ala Gly Leu Ala Ala Leu His Phe Met Lys Arg Leu Val 
                245                 250                 255     

Asp Glu His Ala Ala Lys Val Ile Gly Ala Asn Glu Tyr Leu Ser Asp 
            260                 265                 270         

Gly Phe Asn Thr Asn Glu Tyr Ala Met Asp Leu Asp Thr Val Ala Ala 
        275                 280                 285             

Met Ser Phe Ile Asn Asn Ser Asn Leu His Trp Lys Val Ala Pro Leu 
    290                 295                 300                 

Pro Lys Gly Val Thr Tyr Ala Val Pro Thr Ala Gly Leu Asn Leu Val 
305                 310                 315                 320 

Ile Phe Asn Ala Ala Thr Ser Ala Gln Lys Ala Ala Ala Ala Lys Tyr 
                325                 330                 335     

Leu Asn Phe Leu Ile Ser Val Pro Ser Thr Ile Glu Trp Ala Glu Gln 
            340                 345                 350         

Thr Gly Tyr Leu Pro Val Arg Gln Ser Ala Leu Thr Asn Ser Ala Trp 
        355                 360                 365             

Thr Ser Phe Ile Lys Thr His Pro Asn Gln Gly Val Ala Pro Asn Glu 
    370                 375                 380                 

Leu Lys Tyr Ala Tyr Phe Ser Pro Arg Leu Ala Ser Leu Tyr Ser Ala 
385                 390                 395                 400 

Glu Gln Glu Met Thr Thr Gln Ile Gly Asn Met Leu Ala Gly Arg Gln 
                405                 410                 415     

Thr Pro Gln Val Thr Leu Gln Asn Met Ala Asn Ile Thr Asn Gln Ala 
            420                 425                 430         

Leu Ala Gln Gly Asn Ser 
        435             

<210>   162
<211>   438
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   162
Met Lys His Lys Asn Lys Ala Leu Met Ala Thr Ala Thr Ala Val Val 
                5                   10                  15      

Met Cys Ala Trp Met Ala Thr Gly Cys Gly Asp Glu Glu Thr Gly Gly 
            20                  25                  30          

Gly Gly Gly Ile Pro Met Thr Lys Ser Ser Asn Ala Ser Gly Gln Ala 
        35                  40                  45              

Ala Ser Thr Ala Gln Pro Val Thr Ile Thr Phe Glu Glu Ser Met Pro 
    50                  55                  60                  

Gly Lys Leu Gly Thr Glu Leu Gln Lys Leu Thr Asn Glu Phe Glu Lys 
65                  70                  75                  80  

Gln Asn Pro Asn Ile His Val Gln Leu Ile Phe Asn Gly Ser Tyr Ser 
                85                  90                  95      

Thr Leu Glu Gln Lys Leu Thr Ala Ala Ile Ala Ser Gly Thr Glu Pro 
            100                 105                 110         

Thr Val Ala Gln Val Glu Glu Thr Trp Glu Thr Asn Tyr Val Gln Asn 
        115                 120                 125             

Gly Leu Ile Glu Pro Leu Asp Ser Val Ile Pro Lys Ser Thr Gln Asn 
    130                 135                 140                 

Asp Leu Ile Pro Ile Trp Arg Gln Asp Ser Thr Tyr Asn Gly Lys Leu 
145                 150                 155                 160 

Met Ser Val Pro Phe Asn Lys Ser Ala Tyr Val Leu Tyr Tyr Asn Val 
                165                 170                 175     

Asp Asp Leu Lys Lys Ala Gly Ile Ser Ser Pro Pro Thr Thr Trp Ser 
            180                 185                 190         

Gln Leu Glu Gln Asp Ala Ile Lys Ile Gln Lys Lys Glu Gly Ile Pro 
        195                 200                 205             

Gly Leu Gly Leu Gln Gly Asn Tyr Tyr Thr Phe Glu Met Leu Leu Lys 
    210                 215                 220                 

Gln Ala Gly Gly Gln Ile Leu Asn Ala Arg Asn Thr Lys Ala Ala Phe 
225                 230                 235                 240 

Asp Ser Ser Ala Gly Leu Ala Ala Leu His Phe Met Lys Arg Leu Val 
                245                 250                 255     

Asp Glu His Ala Ala Lys Val Ile Gly Ala Asn Glu Tyr Leu Ser Asp 
            260                 265                 270         

Gly Phe Asn Thr Asn Glu Tyr Ala Met Asp Leu Asp Thr Val Ala Ala 
        275                 280                 285             

Met Ser Phe Ile Asn Asn Ser Asn Leu His Trp Lys Val Ala Pro Leu 
    290                 295                 300                 

Pro Lys Gly Val Thr Tyr Ala Val Pro Thr Ala Gly Leu Asn Leu Val 
305                 310                 315                 320 

Ile Phe Asn Ala Ala Thr Ser Ala Gln Lys Ala Ala Ala Ala Lys Tyr 
                325                 330                 335     

Leu Asn Phe Leu Ile Ser Val Pro Ser Thr Ile Glu Trp Ala Glu Gln 
            340                 345                 350         

Thr Gly Tyr Leu Pro Val Arg Gln Ser Ala Leu Thr Asn Ser Ala Trp 
        355                 360                 365             

Thr Ser Phe Leu Lys Thr His Pro Asn Gln Gly Val Ala Pro Asn Glu 
    370                 375                 380                 

Leu Lys Tyr Ala Tyr Phe Ser Pro Arg Leu Ala Ser Leu Tyr Ser Ala 
385                 390                 395                 400 

Glu Gln Glu Met Thr Thr Gln Ile Gly Asn Met Leu Ala Gly Arg Gln 
                405                 410                 415     

Thr Pro Gln Val Thr Leu Gln Asn Met Ala Asn Ile Thr Asn Gln Ala 
            420                 425                 430         

Leu Ala Gln Gly Asn Ser 
        435             

<210>   163
<211>   438
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   163
Met Lys His Lys Asn Lys Ala Leu Met Ala Thr Ala Thr Ala Val Val 
                5                   10                  15      

Met Cys Ala Trp Met Ala Thr Gly Cys Gly Asp Glu Glu Thr Gly Gly 
            20                  25                  30          

Gly Gly Gly Ile Pro Met Thr Lys Ser Ser Asn Ala Ser Gly Gln Ala 
        35                  40                  45              

Ala Ser Thr Ala Gln Pro Val Thr Ile Thr Phe Glu Glu Ser Met Pro 
    50                  55                  60                  

Gly Lys Leu Gly Thr Glu Leu Gln Lys Leu Thr Asn Glu Phe Glu Lys 
65                  70                  75                  80  

Gln Asn Pro Asn Ile His Val Gln Leu Ile Phe Asn Gly Ser Tyr Ser 
                85                  90                  95      

Thr Leu Glu Gln Lys Leu Thr Ala Ala Ile Ala Ser Gly Thr Glu Pro 
            100                 105                 110         

Thr Val Ala Gln Val Glu Glu Thr Trp Glu Thr Asn Tyr Val Gln Asn 
        115                 120                 125             

Gly Leu Ile Glu Pro Leu Asp Ser Val Ile Pro Lys Ser Thr Gln Asn 
    130                 135                 140                 

Asp Leu Ile Pro Ile Trp Arg Gln Asp Ser Thr Tyr Asn Gly Lys Leu 
145                 150                 155                 160 

Met Ser Val Pro Phe Asn Lys Ser Ala Tyr Val Leu Tyr Tyr Asn Val 
                165                 170                 175     

Asp Asp Leu Lys Lys Ala Gly Ile Ser Ser Pro Pro Thr Thr Trp Ser 
            180                 185                 190         

Gln Leu Glu Gln Asp Ala Ile Lys Ile Gln Lys Lys Glu Gly Ile Pro 
        195                 200                 205             

Gly Leu Gly Leu Gln Gly Asn Tyr Tyr Thr Phe Glu Met Leu Leu Lys 
    210                 215                 220                 

Gln Ala Gly Gly Gln Ile Ile Asn Ala Arg Asn Thr Lys Ala Ala Phe 
225                 230                 235                 240 

Asp Ser Ser Ala Gly Leu Ala Ala Leu His Phe Met Lys Arg Leu Val 
                245                 250                 255     

Asp Glu His Ala Ala Lys Val Ile Gly Ala Asn Glu Tyr Leu Ser Asp 
            260                 265                 270         

Gly Phe Asn Thr Asn Glu Tyr Ala Met Asp Leu Asp Thr Val Ala Ala 
        275                 280                 285             

Met Ser Phe Ile Asn Asn Ser Asn Leu His Trp Lys Val Ala Pro Leu 
    290                 295                 300                 

Pro Lys Gly Val Thr Tyr Ala Val Pro Thr Ala Gly Leu Asn Leu Val 
305                 310                 315                 320 

Ile Phe Asn Ala Ala Thr Ser Ala Gln Lys Ala Ala Ala Ala Lys Tyr 
                325                 330                 335     

Leu Asn Phe Leu Ile Ser Val Pro Ser Thr Ile Glu Trp Ala Glu Gln 
            340                 345                 350         

Thr Gly Tyr Leu Pro Val Arg Gln Ser Ala Leu Thr Asn Ser Ala Trp 
        355                 360                 365             

Thr Ser Phe Ile Lys Thr His Pro Asn Gln Gly Val Ala Pro Asn Glu 
    370                 375                 380                 

Leu Lys Tyr Ala Tyr Phe Ser Pro Arg Leu Ala Ser Leu Tyr Ser Ala 
385                 390                 395                 400 

Glu Gln Glu Met Thr Thr Gln Ile Gly Asn Met Leu Ala Gly Arg Gln 
                405                 410                 415     

Thr Pro Gln Val Thr Leu Gln Asn Met Ala Asn Ile Thr Asn Gln Ala 
            420                 425                 430         

Leu Ala Gln Gly Asn Ser 
        435             

<210>   164
<211>   438
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   164
Met Lys His Lys Asn Lys Ala Leu Met Ala Thr Ala Thr Ala Val Val 
                5                   10                  15      

Met Cys Ala Trp Met Ala Thr Gly Cys Gly Asp Glu Glu Thr Gly Gly 
            20                  25                  30          

Gly Gly Gly Ile Pro Met Thr Lys Ser Ser Asn Ala Ser Gly Gln Ala 
        35                  40                  45              

Ala Ser Thr Ala Gln Pro Val Thr Ile Thr Phe Glu Glu Ser Met Pro 
    50                  55                  60                  

Gly Lys Leu Gly Thr Glu Leu Gln Lys Leu Thr Asn Glu Phe Glu Lys 
65                  70                  75                  80  

Gln Asn Pro Asn Ile His Val Gln Leu Ile Phe Asn Gly Ser Tyr Ser 
                85                  90                  95      

Thr Leu Glu Gln Lys Leu Thr Ala Ala Ile Ala Ser Gly Thr Glu Pro 
            100                 105                 110         

Thr Val Ala Gln Val Glu Glu Thr Trp Glu Thr Asn Tyr Val Gln Asn 
        115                 120                 125             

Gly Leu Ile Glu Pro Leu Asp Ser Val Ile Pro Lys Ser Thr Gln Asn 
    130                 135                 140                 

Asp Leu Ile Pro Ile Trp Arg Gln Asp Ser Thr Tyr Asn Gly Lys Leu 
145                 150                 155                 160 

Met Ser Val Pro Phe Asn Lys Ser Ala Tyr Val Leu Tyr Tyr Asn Val 
                165                 170                 175     

Asp Asp Leu Lys Lys Ala Gly Ile Ser Ser Pro Pro Thr Thr Trp Ser 
            180                 185                 190         

Gln Leu Glu Gln Asp Ala Ile Lys Ile Gln Lys Lys Glu Gly Ile Pro 
        195                 200                 205             

Gly Leu Gly Leu Gln Gly Asn Tyr Tyr Thr Phe Glu Met Leu Leu Lys 
    210                 215                 220                 

Gln Ala Gly Gly Gln Ile Leu Asn Ala Arg Asn Thr Lys Ala Ala Phe 
225                 230                 235                 240 

Asp Ser Ser Ala Gly Leu Ala Ala Leu His Phe Met Lys Arg Leu Val 
                245                 250                 255     

Asp Glu His Ala Ala Lys Val Ile Gly Ala Asn Glu Tyr Leu Ser Asp 
            260                 265                 270         

Gly Phe Asn Thr Asn Glu Tyr Ala Met Asp Leu Asp Thr Val Ala Ala 
        275                 280                 285             

Met Ser Phe Ile Asn Asn Ser Asn Leu His Trp Lys Val Ala Pro Leu 
    290                 295                 300                 

Pro Lys Gly Val Thr Tyr Ala Val Pro Thr Ala Gly Leu Asn Leu Val 
305                 310                 315                 320 

Ile Phe Asn Ala Ala Thr Ser Ala Gln Lys Ala Ala Ala Ala Lys Tyr 
                325                 330                 335     

Leu Asn Phe Leu Ile Ser Val Pro Ser Thr Ile Glu Trp Ala Glu Gln 
            340                 345                 350         

Thr Gly Tyr Leu Pro Val Arg Gln Ser Ala Leu Thr Asn Ser Ala Trp 
        355                 360                 365             

Thr Ser Phe Ile Lys Thr His Pro Asn Gln Gly Val Ala Pro Asn Glu 
    370                 375                 380                 

Leu Lys Tyr Ala Tyr Phe Ser Pro Arg Leu Ala Ser Leu Tyr Ser Ala 
385                 390                 395                 400 

Asp Gln Glu Met Thr Thr Gln Ile Gly Asn Met Leu Ala Gly Arg Gln 
                405                 410                 415     

Thr Pro Gln Val Thr Leu Gln Asn Met Ala Asn Ile Thr Asn Gln Ala 
            420                 425                 430         

Leu Ala Gln Gly Asn Ser 
        435             

<210>   165
<211>   438
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   165
Met Lys His Lys Asn Lys Ala Leu Met Ala Thr Ala Thr Ala Ile Val 
                5                   10                  15      

Met Cys Ala Trp Met Ala Thr Gly Cys Gly Asp Glu Glu Thr Gly Gly 
            20                  25                  30          

Gly Gly Gly Ile Pro Met Thr Lys Ser Ser Asn Ala Ser Gly Gln Ala 
        35                  40                  45              

Ala Ser Thr Ala Gln Pro Val Thr Ile Thr Phe Glu Glu Ser Met Pro 
    50                  55                  60                  

Gly Lys Leu Gly Thr Glu Leu Gln Lys Leu Thr Asn Glu Phe Glu Lys 
65                  70                  75                  80  

Gln Asn Pro Asn Ile His Val Gln Leu Ile Phe Asn Gly Ser Tyr Ser 
                85                  90                  95      

Thr Leu Glu Gln Lys Leu Thr Ala Ala Ile Ala Ser Gly Thr Glu Pro 
            100                 105                 110         

Thr Val Ala Gln Val Glu Glu Thr Trp Glu Thr Asn Tyr Val Gln Asn 
        115                 120                 125             

Gly Leu Ile Glu Pro Leu Asp Ser Val Ile Pro Lys Ser Thr Gln Asn 
    130                 135                 140                 

Asp Leu Ile Pro Ile Trp Arg Gln Asp Ser Thr Tyr Asn Gly Lys Leu 
145                 150                 155                 160 

Met Ser Val Pro Phe Asn Lys Ser Ala Tyr Val Leu Tyr Tyr Asn Val 
                165                 170                 175     

Asp Asp Leu Lys Lys Ala Gly Ile Ser Ser Pro Pro Thr Thr Trp Ser 
            180                 185                 190         

Gln Leu Glu Gln Asp Ala Ile Lys Ile Gln Lys Lys Glu Gly Ile Pro 
        195                 200                 205             

Gly Leu Gly Leu Gln Gly Asn Tyr Tyr Thr Phe Glu Met Leu Leu Lys 
    210                 215                 220                 

Gln Ala Gly Gly Gln Ile Leu Asn Ala Arg Asn Thr Lys Ala Ala Phe 
225                 230                 235                 240 

Asp Ser Ser Ala Gly Leu Ala Ala Leu His Phe Met Lys Arg Leu Val 
                245                 250                 255     

Asp Glu His Ala Ala Lys Val Ile Gly Ala Asn Glu Tyr Leu Ser Asp 
            260                 265                 270         

Gly Phe Asn Thr Asn Glu Tyr Ala Met Asp Leu Asp Thr Val Ala Ala 
        275                 280                 285             

Met Ser Phe Ile Asn Asn Ser Asn Leu His Trp Lys Val Ala Pro Leu 
    290                 295                 300                 

Pro Lys Gly Val Thr Tyr Ala Val Pro Thr Ala Gly Leu Asn Leu Val 
305                 310                 315                 320 

Ile Phe Asn Ala Ala Thr Ser Ala Gln Lys Ala Ala Ala Ala Lys Tyr 
                325                 330                 335     

Leu Asn Phe Leu Ile Ser Val Pro Ser Thr Ile Glu Trp Ala Glu Gln 
            340                 345                 350         

Thr Gly Tyr Leu Pro Val Arg Gln Ser Ala Leu Thr Asn Ser Ala Trp 
        355                 360                 365             

Thr Ser Phe Ile Lys Thr His Pro Asn Gln Gly Val Ala Pro Asn Glu 
    370                 375                 380                 

Leu Lys Tyr Ala Tyr Phe Ser Pro Arg Leu Ala Ser Leu Tyr Ser Ala 
385                 390                 395                 400 

Glu Gln Glu Met Thr Thr Gln Ile Gly Asn Met Leu Ala Gly Arg Gln 
                405                 410                 415     

Thr Pro Gln Val Thr Leu Gln Asn Met Ala Asn Ile Thr Asn Gln Ala 
            420                 425                 430         

Leu Ala Gln Gly Asn Ser 
        435             

<210>   166
<211>   1317
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   166
gtgaaacaca aaaacaaggc cctcatggcg acagccacag cggtggtgat gtgcgcgtgg       60

atggccactg gatgcggaga cgaggagacc ggcggcgggg gcggaatccc catgaccaag      120

tcctccaacg catcgggaca agccgcgagc accgcgcaac ctgtgaccat cacctttgag      180

gaatccatgc ctggcaagct cgggaccgaa ctccaaaagc tgacgaacga gtttgagaag      240

caaaatccca acatccacgt gcagctcatc ttcaatggct cgtacagcac gttggagcag      300

aagttgaccg ccgccattgc gtccggcaca gagcccacgg tggcgcaggt cgaggagacg      360

tgggagacga attacgtgca gaacggtctg attgagcccc tcgactccgt cattccgaaa      420

tccacgcaga acgatctaat cccgatttgg cgtcaggact cgacgtacaa cggccgtttg      480

atgtccgttc ccttcaacaa gtccgcctac gtcctgtact acaatgtgga cgatttaaag      540

aaggccggga tttcttcgcc gccgacaacc tggagccagc tcgaacagga tgccatcaag      600

attcaaaaga aagaaggcat tccgggcctc ggcctgcagg gcaactatta cacctttgaa      660

atgctcttaa aacaagcggg tggacagatc ctgaacgcca gaaacaccaa ggcggccttc      720

gatagctcag ccggtctcgc agcgctccat ttcatgaagc gcttggtgga tgaacacgcg      780

gccaaggtca tcggcgcgaa cgaatacctc tccgacggtt tcaacacgaa cgagtacgcg      840

atggacctcg acacggtcgc cgcgatgtcg ttcatcaaca actcgaacct ccattggaaa      900

gttgcgccgc tcccaaaggg cgtgacctac gccgtcccca cggccggttt gaacttggtc      960

attttcaacg cagcgacatc cgctcagaaa gcggcggcgg cgaagtatct gaacttcctc     1020

atttctgtac catcgaccat cgagtgggcg gaacagacag gctacctccc cgtccgccaa     1080

agcgcactca ccaattcggc ctggacgagc ttcatcaaga cccatccgaa tcagggggtc     1140

gcacccaacg agctgaaata cgcctatttc tcccctcggc tcgcttcgct ctactccgcg     1200

gagcaagaga tgaccacaca gattggcaac atgctggcgg gtcggcagac gccgcaggtg     1260

accctgcaga acatggcgaa catcacgaac caagcgctcg cccagggcaa ttcatga        1317


<210>   167
<211>   1317
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   167
gtgaaacaca aaaacaaggc cctcatggcg acagccacag cggtggtgat gtgcgcgtgg       60

atggccactg gatgcggaga cgaggagacc ggcggcgggg gcggaatccc catgaccaag      120

tcctccaacg catcgggaca agccgcgagc accgcgcaac ctgtgaccat cacctttgag      180

gaatccatgc ctggcaagct cgggaccgaa ctccaaaagc tgacgaacga gtttgagaag      240

caaaatccca acatccacgt gcagctcatc ttcaatggct cgtacagcac gttggagcag      300

aagttgaccg ccgccattgc gtccggcaca gagcccacgg tggcgcaggt cgaggagacg      360

tgggagacga attacgtgca gaacggtctg attgagcccc tcgactccgt cattccgaaa      420

tccacgcaga acgatctaat cccgatttgg cgtcaggact cgacgtacaa cggcaagttg      480

atgtccgttc ccttcaacaa gtccgcctac gtcctgtact acaatgtgga cgatttaaag      540

aaggccggga tttcttcgcc gccgacaacc tggagccagc tcgaacagga tgccatcaag      600

attcaaaaga aagaaggcat tccgggcctc ggcctgcagg gcaactatta cacctttgaa      660

atgctcttaa aacaagcggg tggacagatc ctgaacgcca gaaacaccaa ggcggccttc      720

gatagctcag ccggtctcgc agcgctccat ttcatgaagc gcttggtgga tgaacacgcg      780

gccaaggtca tcggcgcgaa cgaatacctc tccgacggtt tcaacacgaa cgagtacgcg      840

atggacctcg acacggtcgc cgcgatgtcg ttcatcaaca actcgaacct ccattggaaa      900

gttgcgccgc tcccaaaggg cgtgacctac gccgtcccca cggccggttt gaacttggtc      960

attttcaacg cagcgacatc cgctcagaaa gcggcggcgg cgaagtatct gaacttcctc     1020

atttctgtac catcgaccat cgagtgggcg gaacagacag gctacctccc cgtccgccaa     1080

agcgcactca ccaattcggc ctggacgagc ttcttaaaga cccatccgaa tcagggggtc     1140

gcacccaacg agctgaaata cgcctatttc tcccctcggc tcgcttcgct ctactccgcg     1200

gagcaagaga tgaccacaca gattggcaac atgctggcgg gtcggcagac gccgcaggtg     1260

accctgcaga acatggcgaa catcacgaac caagcgctcg cccagggcaa ttcatga        1317


<210>   168
<211>   1317
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   168
gtgaaacaca aaaacaaggc cctcatggcg acagccacag cggtggtgat gtgcgcgtgg       60

atggccactg gatgcggaga cgaggagacc ggcggcgggg gcggaatccc catgaccaag      120

tcctccaacg catcgggaca agccgcgagc accgcgcaac ctgtgaccat cacctttgag      180

gaatccatgc ctggcaagct cgggaccgaa ctccaaaagc tgacgaacga gtttgagaag      240

caaaatccca acatccacgt gcagctcatc ttcaatggct cgtacagcac gttggagcag      300

aagttgaccg ccgccattgc gtccggcaca gagcccacgg tggcgcaggt cgaggagacg      360

tgggagacga attacgtgca gaacggtctg attgagcccc tcgactccgt cattccgaaa      420

tccacgcaga acgatctaat cccgatttgg cgtcaggact cgacgtacaa cggcaagttg      480

atgtccgttc ccttcaacaa gtccgcctac gtcctgtact acaatgtgga cgatttaaag      540

aaggccggga tttcttcgcc gccgacaacc tggagccagc tcgaacagga tgccatcaag      600

attcaaaaga aagaaggcat tccgggcctc ggcctgcagg gcaactatta cacctttgaa      660

atgctcttaa aacaagcggg tggacagatc attaacgcca gaaacaccaa ggcggccttc      720

gatagctcag ccggtctcgc agcgctccat ttcatgaagc gcttggtgga tgaacacgcg      780

gccaaggtca tcggcgcgaa cgaatacctc tccgacggtt tcaacacgaa cgagtacgcg      840

atggacctcg acacggtcgc cgcgatgtcg ttcatcaaca actcgaacct ccattggaaa      900

gttgcgccgc tcccaaaggg cgtgacctac gccgtcccca cggccggttt gaacttggtc      960

attttcaacg cagcgacatc cgctcagaaa gcggcggcgg cgaagtatct gaacttcctc     1020

atttctgtac catcgaccat cgagtgggcg gaacagacag gctacctccc cgtccgccaa     1080

agcgcactca ccaattcggc ctggacgagc ttcatcaaga cccatccgaa tcagggggtc     1140

gcacccaacg agctgaaata cgcctatttc tcccctcggc tcgcttcgct ctactccgcg     1200

gagcaagaga tgaccacaca gattggcaac atgctggcgg gtcggcagac gccgcaggtg     1260

accctgcaga acatggcgaa catcacgaac caagcgctcg cccagggcaa ttcatga        1317


<210>   169
<211>   1317
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   169
gtgaaacaca aaaacaaggc cctcatggcg acagccacag cggtggtgat gtgcgcgtgg       60

atggccactg gatgcggaga cgaggagacc ggcggcgggg gcggaatccc catgaccaag      120

tcctccaacg catcgggaca agccgcgagc accgcgcaac ctgtgaccat cacctttgag      180

gaatccatgc ctggcaagct cgggaccgaa ctccaaaagc tgacgaacga gtttgagaag      240

caaaatccca acatccacgt gcagctcatc ttcaatggct cgtacagcac gttggagcag      300

aagttgaccg ccgccattgc gtccggcaca gagcccacgg tggcgcaggt cgaggagacg      360

tgggagacga attacgtgca gaacggtctg attgagcccc tcgactccgt cattccgaaa      420

tccacgcaga acgatctaat cccgatttgg cgtcaggact cgacgtacaa cggcaagttg      480

atgtccgttc ccttcaacaa gtccgcctac gtcctgtact acaatgtgga cgatttaaag      540

aaggccggga tttcttcgcc gccgacaacc tggagccagc tcgaacagga tgccatcaag      600

attcaaaaga aagaaggcat tccgggcctc ggcctgcagg gcaactatta cacctttgaa      660

atgctcttaa aacaagcggg tggacagatc ctgaacgcca gaaacaccaa ggcggccttc      720

gatagctcag ccggtctcgc agcgctccat ttcatgaagc gcttggtgga tgaacacgcg      780

gccaaggtca tcggcgcgaa cgaatacctc tccgacggtt tcaacacgaa cgagtacgcg      840

atggacctcg acacggtcgc cgcgatgtcg ttcatcaaca actcgaacct ccattggaaa      900

gttgcgccgc tcccaaaggg cgtgacctac gccgtcccca cggccggttt gaacttggtc      960

attttcaacg cagcgacatc cgctcagaaa gcggcggcgg cgaagtatct gaacttcctc     1020

atttctgtac catcgaccat cgagtgggcg gaacagacag gctacctccc cgtccgccaa     1080

agcgcactca ccaattcggc ctggacgagc ttcatcaaga cccatccgaa tcagggggtc     1140

gcacccaacg agctgaaata cgcctatttc tcccctcggc tcgcttcgct ctactccgcg     1200

gatcaagaga tgaccacaca gattggcaac atgctggcgg gtcggcagac gccgcaggtg     1260

accctgcaga acatggcgaa catcacgaac caagcgctcg cccagggcaa ttcatga        1317


<210>   170
<211>   1317
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   170
gtgaaacaca aaaacaaggc cctcatggcg acagccacag cgattgtgat gtgcgcgtgg       60

atggccactg gatgcggaga cgaggagacc ggcggcgggg gcggaatccc catgaccaag      120

tcctccaacg catcgggaca agccgcgagc accgcgcaac ctgtgaccat cacctttgag      180

gaatccatgc ctggcaagct cgggaccgaa ctccaaaagc tgacgaacga gtttgagaag      240

caaaatccca acatccacgt gcagctcatc ttcaatggct cgtacagcac gttggagcag      300

aagttgaccg ccgccattgc gtccggcaca gagcccacgg tggcgcaggt cgaggagacg      360

tgggagacga attacgtgca gaacggtctg attgagcccc tcgactccgt cattccgaaa      420

tccacgcaga acgatctaat cccgatttgg cgtcaggact cgacgtacaa cggcaagttg      480

atgtccgttc ccttcaacaa gtccgcctac gtcctgtact acaatgtgga cgatttaaag      540

aaggccggga tttcttcgcc gccgacaacc tggagccagc tcgaacagga tgccatcaag      600

attcaaaaga aagaaggcat tccgggcctc ggcctgcagg gcaactatta cacctttgaa      660

atgctcttaa aacaagcggg tggacagatc ctgaacgcca gaaacaccaa ggcggccttc      720

gatagctcag ccggtctcgc agcgctccat ttcatgaagc gcttggtgga tgaacacgcg      780

gccaaggtca tcggcgcgaa cgaatacctc tccgacggtt tcaacacgaa cgagtacgcg      840

atggacctcg acacggtcgc cgcgatgtcg ttcatcaaca actcgaacct ccattggaaa      900

gttgcgccgc tcccaaaggg cgtgacctac gccgtcccca cggccggttt gaacttggtc      960

attttcaacg cagcgacatc cgctcagaaa gcggcggcgg cgaagtatct gaacttcctc     1020

atttctgtac catcgaccat cgagtgggcg gaacagacag gctacctccc cgtccgccaa     1080

agcgcactca ccaattcggc ctggacgagc ttcatcaaga cccatccgaa tcagggggtc     1140

gcacccaacg agctgaaata cgcctatttc tcccctcggc tcgcttcgct ctactccgcg     1200

gagcaagaga tgaccacaca gattggcaac atgctggcgg gtcggcagac gccgcaggtg     1260

accctgcaga acatggcgaa catcacgaac caagcgctcg cccagggcaa ttcatga        1317


<210>   171
<211>   466
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   171
Met Met Gln Ala Glu Val Ala Gln Ala Glu Tyr Arg Pro Asn Leu Gly 
                5                   10                  15      

Tyr Val Val Thr Val Val Val Ile Ala Ser Leu Gly Gly Leu Leu Phe 
            20                  25                  30          

Gly Tyr Asp Thr Gly Val Ile Ala Gly Ala Asn Glu Phe Leu Lys Ser 
        35                  40                  45              

Glu Phe His Met Ser Ala Ala Thr Thr Gly Leu Val Ser Ser Ser Ile 
    50                  55                  60                  

Asp Leu Gly Ala Met Leu Gly Val Leu Ile Ala Gly Phe Leu Gly Asp 
65                  70                  75                  80  

Ser Phe Gly Arg Lys Lys Ala Leu Ser Val Ala Gly Ile Ile Phe Ile 
                85                  90                  95      

Ala Ser Ser Leu Ile Ser Ala Phe Ala Pro Ser Val Gly Val Leu Val 
            100                 105                 110         

Leu Gly Arg Phe Ile Gly Gly Val Gly Ile Gly Leu Ala Ser Leu Leu 
        115                 120                 125             

Ser Pro Leu Tyr Ile Ala Glu Ile Ala Pro Pro Arg Ile Arg Gly Arg 
    130                 135                 140                 

Leu Val Gly Ser Asn Gln Leu Ala Ile Val Ser Gly Ile Phe Ile Val 
145                 150                 155                 160 

Tyr Phe Val Asn Ala Ala Ile Val Ser Ser His Thr Thr Ala Trp Asn 
                165                 170                 175     

Gln Thr Thr Gly Trp Arg Trp Met Phe Ala Met Gly Val Ile Pro Ala 
            180                 185                 190         

Val Ile Phe Phe Phe Leu Leu Phe Leu Val Pro Glu Ser Pro Arg Tyr 
        195                 200                 205             

Leu Met Lys Arg Gly Arg Glu Glu Gln Ala Ile Ser Ile Leu Glu Arg 
    210                 215                 220                 

Val Ser Gly Pro Glu Arg Ala Arg Trp Asp Val Glu Glu Ile Arg Lys 
225                 230                 235                 240 

Ser Leu Glu Val Val Pro Asp Ser Leu Phe Gln Glu Leu Ser Arg Pro 
                245                 250                 255     

Gly Ile Arg Lys Ala Leu Gly Ile Gly Val Val Leu Ala Ile Phe Gln 
            260                 265                 270         

Gln Phe Thr Gly Thr Asn Ala Val Gly Tyr Tyr Ala Pro Met Ile Phe 
        275                 280                 285             

Lys Ala Ala Gly Ala Gly Thr Asn Ala Ser Phe Tyr Asp Thr Val Trp 
    290                 295                 300                 

Ile Gly Ala Ile Lys Val Ile Phe Val Ile Val Leu Met Leu Ile Val 
305                 310                 315                 320 

Asp Arg Val Gly Arg Lys Arg Leu Leu Val Trp Asn Gly Met Leu Met 
                325                 330                 335     

Ala Leu Phe Leu Ala Ile Leu Gly Val Ala Phe Ser Leu Pro His Met 
            340                 345                 350         

Ile Thr Trp Leu Val Leu Ala Leu Val Phe Ala His Thr Ile Ala Tyr 
        355                 360                 365             

Glu Leu Ser Trp Gly Gly Gly Val Trp Ile Val Leu Ser Glu Ile Tyr 
    370                 375                 380                 

Pro Thr Ala Ile Arg Gly Arg Ala Met Ala Ile Ala Ser Phe Ala Leu 
385                 390                 395                 400 

Trp Phe Ala Thr Tyr Leu Val Ala Gln Phe Phe Pro Ile Leu Leu Gln 
                405                 410                 415     

Ala Ile Gly Gly Thr Trp Thr Phe Trp Ile Phe Ala Leu Phe Cys Ile 
            420                 425                 430         

Ala Met Ala Val Phe Met Gln Arg Val Val Pro Glu Thr Ser Lys Lys 
        435                 440                 445             

Thr Met Glu Lys Ile Gln Ser Asp Trp Leu Gln Ser Glu Arg Gly Ser 
    450                 455                 460                 

Ser Leu 
465     

<210>   172
<211>   1401
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   172
ttgatgcagg cagaagtggc gcaggccgag tatcggccga atctgggcta cgtcgtgacg       60

gtcgtcgtca ttgcatcgct cggcgggctt ctcttcgggt atgacaccgg cgtgatcgca      120

ggggcgaacg agtttctgaa atcggagttt cacatgagtg cagcgaccac cggactcgtc      180

tcgagcagca tcgatctcgg cgccatgctc ggcgtgctca tcgcgggctt cctgggcgac      240

tcgttcggaa ggaagaaagc gctgtcggtc gcgggcatca tcttcatcgc ctcgagcttg      300

atctcggcct tcgcgccgag cgtcggcgtg ttggttctcg ggcggtttat cgggggcgtc      360

ggcatcggtc tggcgtcgct gttgtcgccg ctctacatcg ccgagatcgc accgccgcgg      420

atccgcgggc gattggtcgg gtcgaaccaa ttggctatcg tgtccgggat tttcatcgtc      480

tactttgtga acgcggctat cgtcagttcg cacaccacgg cctggaacca gacgacgggc      540

tggcgctgga tgtttgccat gggtgtcatt ccggccgtca tctttttctt cctgctcttc      600

cttgtgccgg agagcccgag gtatctcatg aagcggggac gcgaagagca ggccatctcg      660

attctcgaac gcgtgagcgg ccctgagcgg gcgcggtggg acgtcgagga gattcgcaaa      720

tcgctcgaag tcgtgccgga ttcgttgttt caagaactgt cgcgcccggg cattcgaaag      780

gcgctcggca tcggcgtcgt gctcgcgatc ttccaacagt tcacgggcac caacgccgtg      840

ggctattacg ccccgatgat cttcaaggcg gccggcgcag gcaccaacgc gtcgttctac      900

gacacggttt ggattggcgc catcaaggtc atcttcgtca tcgtgctgat gctcatcgtc      960

gatcgcgtcg gaagaaagcg gttgcttgtg tggaacggga tgctcatggc gctctttctc     1020

gccatcctgg gcgtcgcctt ttcactgccg cacatgatca cgtggctggt cctcgcgctt     1080

gtgttcgcgc acaccatcgc ctacgagctg tcctggggcg gcggcgtgtg gattgtgttg     1140

tccgagatct atccgactgc catccgcggc cgcgccatgg ccatcgcgtc ctttgcgctg     1200

tggttcgcca catacctcgt ggcgcagttc ttcccgattt tgttgcaggc tatcggcggc     1260

acgtggacgt tttggatctt cgcgctgttc tgcatcgcca tggccgtctt catgcagcgg     1320

gtcgtgccgg agacgagcaa gaagacgatg gagaagatcc aaagcgactg gctccagtcg     1380

gagcgaggaa gctctctgtg a                                               1401


<210>   173
<211>   441
<212>   PRT
<213>   Pediococcus pentosaceus ATCC 25745

<400>   173
Tyr Val Ile Leu Ile Ser Cys Ala Ala Ala Leu Gly Gly Leu Leu Phe 
                5                   10                  15      

Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala Val Gly Phe Leu Gln Ile 
            20                  25                  30          

Lys Phe Thr Leu Ser Ser Ala Gln Val Gly Trp Val Thr Ser Cys Ile 
        35                  40                  45              

Leu Ile Gly Cys Ala Leu Gly Val Ser Ile Ala Gly Ile Leu Ser Asp 
    50                  55                  60                  

Leu Phe Gly Arg Lys Lys Ile Leu Ala Leu Ser Ala Val Ile Phe Ala 
65                  70                  75                  80  

Leu Ser Ser Leu Gly Ala Ala Phe Ala Gly Ser Tyr Met Ile Leu Val 
                85                  90                  95      

Ile Trp Arg Met Leu Ala Gly Ile Gly Ile Gly Leu Thr Ser Leu Ile 
            100                 105                 110         

Thr Pro Leu Tyr Ile Ala Glu Met Ala Pro Ser Asn Val Arg Gly Lys 
        115                 120                 125             

Leu Val Ser Val Asn Gln Leu Ala Ile Thr Ile Gly Ile Phe Ile Val 
    130                 135                 140                 

Tyr Phe Val Asn Ala Ala Ile Ala Ser Asn Ala Thr Gln Leu Trp Asn 
145                 150                 155                 160 

Val Ser Thr Gly Trp Arg Trp Met Met Gly Val Gly Val Ile Pro Ser 
                165                 170                 175     

Leu Leu Phe Leu Ile Ala Leu Ile Pro Ala Gly Glu Ser Pro Arg Trp 
            180                 185                 190         

Leu Ser Gln His Gly Lys Ser Glu Ala Ala Tyr Lys Val Leu Gln Lys 
        195                 200                 205             

Val Glu Ile Ser Asp Glu Ala Ala Glu Lys Ser Leu Glu Glu Ile Gln 
    210                 215                 220                 

Met Ser Glu Glu Val Val Asp Asp Thr Lys Phe Arg Asp Leu Phe Asn 
225                 230                 235                 240 

Lys Thr Trp Leu Pro Val Leu Ile Ile Gly Val Leu Leu Ala Leu Phe 
                245                 250                 255     

Gln Gln Phe Ser Gly Ser Asn Ala Ile Met Tyr Tyr Ala Pro Glu Ile 
            260                 265                 270         

Phe Lys Gly Ala Gly Phe Gly Gln Ser Gly Ala Phe Met Ala Thr Val 
        275                 280                 285             

Ser Ile Gly Val Ile Asn Met Val Ile Thr Ile Val Ala Leu Gly Leu 
    290                 295                 300                 

Val Asp Lys Ile Gly Arg Lys Lys Leu Leu Gly Trp Gly Ser Phe Ala 
305                 310                 315                 320 

Met Ser Cys Cys Leu Leu Val Val Ser Ile Cys Phe Phe Val His Ala 
                325                 330                 335     

Ala Thr Ser Ile Thr Leu Thr Phe Val Leu Leu Ala Ile Ala Ala Tyr 
            340                 345                 350         

Ala Val Ser Leu Ala Pro Val Thr Trp Ile Leu Ile Ser Glu Ile Phe 
        355                 360                 365             

Pro Leu Lys Ile Arg Gly Arg Ala Met Ser Ile Cys Thr Ala Val Leu 
    370                 375                 380                 

Trp Leu Ser Asp Phe Thr Leu Ser Tyr Thr Phe Pro Ile Leu Thr Gln 
385                 390                 395                 400 

Asn Ile Gly Glu Gly Trp Thr Phe Met Leu Tyr Val Val Val Thr Ala 
                405                 410                 415     

Leu Ser Ala Ile Phe Val Trp Lys Leu Val Pro Glu Thr Arg Gly Lys 
            420                 425                 430         

Ser Leu Glu Glu Ile Glu Val Tyr Trp 
        435                 440     

<210>   174
<211>   446
<212>   PRT
<213>   Bacillus subtilis subsp. subtilis str. 168

<400>   174
Ser Met Gly Phe Val Ile Leu Ile Ser Cys Ala Ala Gly Leu Gly Gly 
                5                   10                  15      

Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala Ile Gly Phe 
            20                  25                  30          

Leu Lys Asp Leu Tyr Ser Leu Ser Pro Phe Met Glu Gly Leu Val Ile 
        35                  40                  45              

Ser Ser Ile Met Ile Gly Gly Val Val Gly Val Gly Ile Ser Gly Phe 
    50                  55                  60                  

Leu Ser Asp Arg Phe Gly Arg Arg Lys Ile Leu Met Thr Ala Ala Leu 
65                  70                  75                  80  

Leu Phe Ala Ile Ser Ala Ile Val Ser Ala Leu Ser Gln Asp Val Ser 
                85                  90                  95      

Thr Leu Ile Ile Ala Arg Ile Ile Gly Gly Leu Gly Ile Gly Met Gly 
            100                 105                 110         

Ser Ser Leu Ser Val Thr Tyr Ile Thr Glu Ala Ala Pro Pro Ala Ile 
        115                 120                 125             

Arg Gly Ser Leu Ser Ser Leu Tyr Gln Leu Phe Thr Ile Leu Gly Ile 
    130                 135                 140                 

Ser Ala Thr Tyr Phe Ile Asn Leu Ala Val Gln Arg Ser Gly Thr Tyr 
145                 150                 155                 160 

Glu Trp Gly Val His Thr Gly Trp Arg Trp Met Leu Ala Tyr Gly Met 
                165                 170                 175     

Val Pro Ser Val Ile Phe Phe Leu Val Leu Leu Val Val Pro Glu Ser 
            180                 185                 190         

Pro Arg Trp Leu Ala Lys Ala Gly Lys Thr Asn Glu Ala Leu Lys Ile 
        195                 200                 205             

Leu Thr Arg Ile Asn Gly Glu Thr Val Ala Lys Glu Glu Leu Lys Asn 
    210                 215                 220                 

Ile Glu Asn Ser Leu Lys Ile Glu Gln Met Gly Ser Leu Ser Gln Leu 
225                 230                 235                 240 

Phe Lys Pro Gly Leu Arg Lys Ala Leu Val Ile Gly Ile Leu Leu Ala 
                245                 250                 255     

Leu Phe Asn Gln Val Ile Gly Met Asn Ala Ile Thr Tyr Tyr Gly Pro 
            260                 265                 270         

Glu Ile Phe Lys Met Met Gly Phe Gly Gln Asn Ala Gly Phe Val Thr 
        275                 280                 285             

Thr Cys Ile Val Gly Val Val Glu Val Ile Phe Thr Val Ile Ala Val 
    290                 295                 300                 

Leu Leu Ile Asp Lys Val Gly Arg Lys Lys Leu Met Ser Ile Gly Ser 
305                 310                 315                 320 

Ala Phe Met Ala Ile Phe Met Ile Leu Ile Gly Thr Ser Phe Tyr Phe 
                325                 330                 335     

Glu Leu Thr Ser Gly Ile Met Met Ile Val Leu Ile Leu Gly Phe Val 
            340                 345                 350         

Ala Ala Phe Cys Val Ser Val Gly Pro Ile Thr Trp Ile Met Ile Ser 
        355                 360                 365             

Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala Ala Gly Ile Ala Thr 
    370                 375                 380                 

Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly Gln Phe Val Pro Met 
385                 390                 395                 400 

Met Ile Asp Ser Phe Gly Leu Ala Tyr Thr Phe Trp Ile Phe Ala Val 
                405                 410                 415     

Ile Asn Ile Leu Cys Phe Leu Phe Val Val Thr Ile Cys Pro Glu Thr 
            420                 425                 430         

Lys Asn Lys Ser Leu Glu Glu Ile Glu Lys Leu Trp Ile Lys 
        435                 440                 445     

<210>   175
<211>   443
<212>   PRT
<213>   Bacillus amyloliquefaciens FZB42

<400>   175
Phe Val Ile Leu Ile Ser Cys Ala Ala Gly Leu Gly Gly Leu Leu Tyr 
                5                   10                  15      

Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala Ile Gly Phe Leu Lys Asp 
            20                  25                  30          

Leu Tyr Arg Leu Ser Pro Phe Met Glu Gly Leu Val Ile Ser Ser Ile 
        35                  40                  45              

Met Ile Gly Gly Val Phe Gly Val Gly Ile Ser Gly Phe Leu Ser Asp 
    50                  55                  60                  

Arg Phe Gly Arg Arg Lys Ile Leu Met Ala Ala Ala Leu Leu Phe Ala 
65                  70                  75                  80  

Val Ser Ala Val Val Ser Ala Leu Ser Gln Ser Val Ser Ser Leu Val 
                85                  90                  95      

Ile Ala Arg Val Ile Gly Gly Leu Gly Ile Gly Met Gly Ser Ser Leu 
            100                 105                 110         

Ser Val Thr Tyr Ile Thr Glu Ala Ala Pro Pro Ala Ile Arg Gly Ser 
        115                 120                 125             

Leu Ser Ser Leu Tyr Gln Leu Phe Thr Ile Leu Gly Ile Ser Gly Thr 
    130                 135                 140                 

Tyr Phe Ile Asn Leu Ala Val Gln Gln Ser Gly Ser Tyr Glu Trp Gly 
145                 150                 155                 160 

Val His Thr Gly Trp Arg Trp Met Leu Ala Tyr Gly Met Ile Pro Ser 
                165                 170                 175     

Val Ile Phe Phe Ile Val Leu Leu Ile Val Pro Glu Ser Pro Arg Trp 
            180                 185                 190         

Leu Ala Lys Ala Gly Arg Arg Asn Glu Ala Leu Ala Val Leu Thr Arg 
        195                 200                 205             

Ile Asn Gly Glu Gln Thr Ala Lys Glu Glu Ile Lys Gln Ile Glu Thr 
    210                 215                 220                 

Ser Leu Gln Leu Glu Lys Met Gly Ser Leu Ser Gln Leu Phe Lys Pro 
225                 230                 235                 240 

Gly Leu Arg Lys Ala Leu Val Ile Gly Ile Leu Leu Ala Leu Phe Asn 
                245                 250                 255     

Gln Val Ile Gly Met Asn Ala Ile Thr Tyr Tyr Gly Pro Glu Ile Phe 
            260                 265                 270         

Lys Met Met Gly Phe Gly Gln Asn Ala Gly Phe Ile Thr Thr Cys Ile 
        275                 280                 285             

Val Gly Val Val Glu Val Ile Phe Thr Ile Ile Ala Val Leu Leu Val 
    290                 295                 300                 

Asp Lys Val Gly Arg Lys Lys Leu Met Gly Val Gly Ser Ala Phe Met 
305                 310                 315                 320 

Ala Leu Phe Met Ile Leu Ile Gly Ala Ser Phe Tyr Phe Gln Leu Ala 
                325                 330                 335     

Ser Gly Pro Ala Leu Val Val Ile Ile Leu Gly Phe Val Ala Ala Phe 
            340                 345                 350         

Cys Val Ser Val Gly Pro Ile Thr Trp Ile Met Ile Ser Glu Ile Phe 
        355                 360                 365             

Pro Asn His Leu Arg Ala Arg Ala Ala Gly Ile Ala Thr Ile Phe Leu 
    370                 375                 380                 

Trp Gly Ala Asn Trp Ala Ile Gly Gln Phe Val Pro Met Met Ile Ser 
385                 390                 395                 400 

Gly Leu Gly Leu Ala Tyr Thr Phe Trp Ile Phe Ala Val Ile Asn Ile 
                405                 410                 415     

Leu Cys Phe Leu Phe Val Val Thr Ile Cys Pro Glu Thr Lys Asn Lys 
            420                 425                 430         

Ser Leu Glu Glu Ile Glu Lys Leu Trp Ile Lys 
        435                 440             

<210>   176
<211>   460
<212>   PRT
<213>   Clostridium acetobutylicum ATCC 824

<400>   176
His Lys His Ser Leu Leu Phe Ile Val Leu Ile Ser Cys Ala Ala Gly 
                5                   10                  15      

Leu Gly Gly Leu Leu Tyr Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala 
            20                  25                  30          

Ile Gly Phe Leu Lys Lys Leu Tyr Asn Leu Ser Pro Ala Met Gln Gly 
        35                  40                  45              

Phe Val Ile Ser Ser Ile Met Val Gly Gly Val Leu Gly Val Gly Phe 
    50                  55                  60                  

Ser Gly Phe Leu Gly Asp Ala Ile Gly Arg Arg Lys Val Leu Met Leu 
65                  70                  75                  80  

Ala Ala Ala Leu Phe Ala Ile Ser Ala Val Ile Ser Ser Ile Ser Thr 
                85                  90                  95      

Ser Ala Phe Met Leu Ile Phe Ala Arg Ile Val Gly Gly Leu Gly Ile 
            100                 105                 110         

Gly Met Ala Ser Ala Leu Ser Val Thr Tyr Ile Thr Glu Cys Ala Pro 
        115                 120                 125             

Pro Ser Ile Arg Gly Arg Leu Ser Ser Leu Tyr Gln Leu Phe Thr Ile 
    130                 135                 140                 

Leu Gly Ile Ser Ile Thr Phe Phe Val Asn Leu Gly Ile Val Asn Met 
145                 150                 155                 160 

Gly Ser Glu Thr Trp Arg Val Ser Thr Gly Trp Arg Tyr Met Leu Ala 
                165                 170                 175     

Cys Gly Thr Val Pro Ala Ile Val Phe Leu Ile Thr Leu Phe Phe Val 
            180                 185                 190         

Pro Glu Ser Pro Arg Phe Leu Val Lys Ser Gly Asn Ile Lys Lys Ala 
        195                 200                 205             

Ala Ala Val Leu Thr Lys Ile Asn Gly Ala Glu Ile Ala Lys Gln Glu 
    210                 215                 220                 

Leu Asp Ser Ile Ser Lys Ser Leu Ala Thr Glu Asn Asp Ser Ser Leu 
225                 230                 235                 240 

Gly Gln Leu Leu Gln Pro Gly Leu Arg Arg Ala Leu Leu Ile Gly Ile 
                245                 250                 255     

Phe Leu Ala Ile Phe Asn Gln Ala Ile Gly Met Asn Ser Ile Thr Tyr 
            260                 265                 270         

Tyr Gly Pro Glu Ile Phe Gln Met Ile Gly Phe Lys Asn Asn Ser Ser 
        275                 280                 285             

Phe Leu Ala Thr Ser Val Ile Gly Val Val Glu Val Phe Ser Thr Ile 
    290                 295                 300                 

Leu Ala Met Phe Leu Ile Asp Lys Leu Gly Arg Lys Lys Leu Met Glu 
305                 310                 315                 320 

Ile Gly Ser Ala Ala Met Ala Val Phe Met Leu Leu Ile Gly Thr Ser 
                325                 330                 335     

Phe Tyr Ile Lys Leu Ser Asn Gly Phe Val Ile Leu Ile Phe Ile Ile 
            340                 345                 350         

Cys Phe Val Val Ser Phe Cys Ile Ser Met Gly Pro Ile Pro Trp Ile 
        355                 360                 365             

Met Ile Pro Glu Ile Phe Pro Asn His Leu Arg Ala Arg Ala Thr Gly 
    370                 375                 380                 

Ile Ala Thr Ile Phe Leu Trp Gly Ala Asn Trp Ala Ile Gly Gln Phe 
385                 390                 395                 400 

Thr Pro Met Leu Leu Asn Gly Ile Gly Gly Ala Tyr Thr Phe Trp Ile 
                405                 410                 415     

Phe Cys Gly Ile Asn Val Ile Cys Phe Leu Val Val Thr Thr Lys Val 
            420                 425                 430         

Pro Glu Thr Lys Asn Lys Ser Leu Glu Glu Ile Glu Lys Phe Trp Ile 
        435                 440                 445             

Pro Lys Ser Lys Gln Asn Ala Lys Gly Ser Ser Val 
    450                 455                 460 

<210>   177
<211>   452
<212>   PRT
<213>   Bacillus cereus ATCC 10987

<400>   177
Tyr Ile Phe Ser Ile Thr Leu Val Ala Ala Ile Gly Gly Leu Leu Phe 
                5                   10                  15      

Gly Tyr Asp Thr Ala Val Ile Ser Gly Ala Glu Glu Ser Leu Lys Val 
            20                  25                  30          

Tyr Phe Ile Asp Ser Leu Gly Leu Gly Ser Leu Ala His Gly Val Thr 
        35                  40                  45              

Val Ser Ser Ala Leu Ile Gly Cys Ile Ile Gly Gly Val Ile Ser Gly 
    50                  55                  60                  

Tyr Cys Ala Ser Lys Phe Gly Arg Lys Arg Ser Leu Ile Ile Ala Ala 
65                  70                  75                  80  

Ile Leu Phe Ile Val Ser Ala Leu Gly Ala Ser Tyr Pro Glu Phe Leu 
                85                  90                  95      

Phe Phe Thr Lys Gly Glu Pro Thr Ile Val Leu Leu Leu Ala Phe Asn 
            100                 105                 110         

Leu Tyr Arg Ile Ile Gly Gly Ile Gly Val Gly Leu Ala Ser Ala Ile 
        115                 120                 125             

Cys Pro Ile Tyr Ile Gly Glu Ile Ala Pro Ala Asp Ile Arg Gly Arg 
    130                 135                 140                 

Leu Val Ser Phe Asn Gln Phe Met Ile Ile Phe Gly Met Leu Val Val 
145                 150                 155                 160 

Tyr Phe Val Asn Trp Gly Ile Ala Asn Gly Glu Thr Leu Glu Trp Ile 
                165                 170                 175     

Asn Asp Val Gly Trp Arg Tyr Met Phe Ala Ser Gly Val Ile Pro Ala 
            180                 185                 190         

Ile Ile Phe Ala Ile Leu Leu Leu Phe Val Pro Glu Thr Pro Arg Tyr 
        195                 200                 205             

Leu Ala Ile Gln His Gln Asp Lys Lys Ala Leu Ala Ile Leu Thr Lys 
    210                 215                 220                 

Ile Asn Gly Pro Leu Glu Ala Lys Ala Ile Leu Asp Asp Ile Lys Gln 
225                 230                 235                 240 

Thr Met Ala Ile Asn Val Ser Ser Glu Lys Leu Phe Ser Tyr Gly Lys 
                245                 250                 255     

Leu Val Ile Ile Val Gly Val Leu Leu Ser Val Phe Gln Gln Phe Val 
            260                 265                 270         

Gly Ile Asn Val Ala Leu Tyr Tyr Ala Pro Arg Ile Phe Glu Ser Met 
        275                 280                 285             

Gly Ala Ala Lys Asp Ser Ser Met Met Gln Thr Ile Ile Met Gly Leu 
    290                 295                 300                 

Val Asn Val Ile Phe Thr Val Ile Ala Ile Leu Thr Val Asp Arg Trp 
305                 310                 315                 320 

Gly Arg Lys Pro Leu Leu Ile Val Gly Ser Ile Gly Met Ala Ile Gly 
                325                 330                 335     

Met Phe Gly Val Ala Ser Met Ala Phe Ala Asn Ile Ile Gly Ile Gly 
            340                 345                 350         

Thr Leu Ile Phe Ile Ile Val Tyr Thr Ala Ser Phe Met Met Ser Trp 
        355                 360                 365             

Gly Pro Ile Cys Trp Val Leu Ile Ser Glu Ile Phe Pro Asn Lys Ile 
    370                 375                 380                 

Arg Gly Gln Ala Val Ala Ile Ala Val Ala Ala Gln Trp Ala Ala Asn 
385                 390                 395                 400 

Tyr Phe Ile Ser Ser Thr Tyr Pro Met Met Met Glu Tyr Ser Gly Gly 
                405                 410                 415     

Leu Thr Tyr Ser Phe Tyr Gly Leu Met Ser Val Leu Ser Ala Leu Phe 
            420                 425                 430         

Val Trp Lys Leu Val Pro Glu Thr Lys Gly Lys Thr Leu Glu Gln Met 
        435                 440                 445             

Glu Asn Thr Trp 
    450         

<210>   178
<211>   466
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   178
Met Met Gln Ala Glu Val Ala Gln Ala Glu Tyr Arg Pro Asn Leu Gly 
                5                   10                  15      

Tyr Val Val Thr Val Val Val Ile Ala Ser Ile Gly Gly Leu Leu Phe 
            20                  25                  30          

Gly Tyr Asp Thr Gly Val Ile Ala Gly Ala Asn Glu Phe Leu Lys Ser 
        35                  40                  45              

Glu Phe His Met Ser Ala Ala Thr Thr Gly Leu Val Ser Ser Ser Ile 
    50                  55                  60                  

Asp Leu Gly Ala Met Leu Gly Val Leu Ile Ala Gly Phe Leu Gly Asp 
65                  70                  75                  80  

Ser Phe Gly Arg Lys Lys Ala Leu Ser Val Ala Gly Ile Ile Phe Ile 
                85                  90                  95      

Ala Ser Ser Leu Ile Ser Ala Phe Ala Pro Ser Val Gly Val Leu Val 
            100                 105                 110         

Leu Gly Arg Phe Ile Gly Gly Val Gly Ile Gly Leu Ala Ser Leu Leu 
        115                 120                 125             

Ser Pro Leu Tyr Ile Ala Glu Ile Ala Pro Pro Arg Ile Arg Gly Arg 
    130                 135                 140                 

Leu Val Gly Ser Asn Gln Leu Ala Ile Val Ser Gly Ile Phe Ile Val 
145                 150                 155                 160 

Tyr Phe Val Asn Ala Ala Ile Val Ser Ser His Thr Thr Ala Trp Asn 
                165                 170                 175     

Gln Thr Thr Gly Trp Arg Trp Met Phe Ala Met Gly Val Ile Pro Ala 
            180                 185                 190         

Val Ile Phe Phe Phe Leu Leu Phe Leu Val Pro Glu Ser Pro Arg Tyr 
        195                 200                 205             

Leu Met Lys Arg Gly Arg Glu Glu Gln Ala Ile Ser Ile Leu Glu Arg 
    210                 215                 220                 

Val Ser Gly Pro Glu Arg Ala Arg Trp Asp Val Glu Glu Ile Arg Lys 
225                 230                 235                 240 

Ser Leu Glu Val Val Pro Asp Ser Leu Phe Gln Glu Leu Ser Arg Pro 
                245                 250                 255     

Gly Ile Arg Lys Ala Leu Gly Ile Gly Val Val Leu Ala Ile Phe Gln 
            260                 265                 270         

Gln Phe Thr Gly Thr Asn Ala Val Gly Tyr Tyr Ala Pro Met Ile Phe 
        275                 280                 285             

Lys Ala Ala Gly Ala Gly Thr Asn Ala Ser Phe Tyr Asp Thr Val Trp 
    290                 295                 300                 

Ile Gly Ala Ile Lys Val Ile Phe Val Ile Val Leu Met Leu Ile Val 
305                 310                 315                 320 

Asp Arg Val Gly Arg Lys Arg Leu Leu Val Trp Asn Gly Met Leu Met 
                325                 330                 335     

Ala Leu Phe Leu Ala Ile Leu Gly Val Ala Phe Ser Leu Pro His Met 
            340                 345                 350         

Ile Thr Trp Leu Val Leu Ala Leu Val Phe Ala His Thr Ile Ala Tyr 
        355                 360                 365             

Glu Leu Ser Trp Gly Gly Gly Val Trp Ile Val Leu Ser Glu Ile Tyr 
    370                 375                 380                 

Pro Thr Ala Ile Arg Gly Arg Ala Met Ala Ile Ala Ser Phe Ala Leu 
385                 390                 395                 400 

Trp Phe Ala Thr Tyr Leu Val Ala Gln Phe Phe Pro Ile Leu Leu Gln 
                405                 410                 415     

Ala Ile Gly Gly Thr Trp Thr Phe Trp Ile Phe Ala Leu Phe Cys Ile 
            420                 425                 430         

Ala Met Ala Val Phe Met Gln Arg Val Val Pro Glu Thr Ser Lys Lys 
        435                 440                 445             

Thr Met Glu Lys Ile Gln Ser Asp Trp Leu Gln Ser Glu Arg Gly Ser 
    450                 455                 460                 

Ser Leu 
465     

<210>   179
<211>   466
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   179
Met Met Gln Ala Glu Val Ala Gln Ala Glu Tyr Arg Pro Asn Leu Gly 
                5                   10                  15      

Tyr Val Val Thr Val Ile Val Ile Ala Ser Leu Gly Gly Leu Leu Phe 
            20                  25                  30          

Gly Tyr Asp Thr Gly Val Ile Ala Gly Ala Asn Glu Phe Leu Lys Ser 
        35                  40                  45              

Glu Phe His Met Ser Ala Ala Thr Thr Gly Leu Val Ser Ser Ser Ile 
    50                  55                  60                  

Asp Leu Gly Ala Met Leu Gly Val Leu Ile Ala Gly Phe Leu Gly Asp 
65                  70                  75                  80  

Ser Phe Gly Arg Lys Lys Ala Leu Ser Val Ala Gly Ile Ile Phe Ile 
                85                  90                  95      

Ala Ser Ser Leu Ile Ser Ala Phe Ala Pro Ser Val Gly Val Leu Val 
            100                 105                 110         

Leu Gly Arg Phe Ile Gly Gly Val Gly Ile Gly Leu Ala Ser Leu Leu 
        115                 120                 125             

Ser Pro Leu Tyr Ile Ala Glu Ile Ala Pro Pro Arg Ile Arg Gly Arg 
    130                 135                 140                 

Leu Val Gly Ser Asn Gln Leu Ala Ile Val Ser Gly Ile Phe Ile Val 
145                 150                 155                 160 

Tyr Phe Val Asn Ala Ala Ile Val Ser Ser His Thr Thr Ala Trp Asn 
                165                 170                 175     

Gln Thr Thr Gly Trp Arg Trp Met Phe Ala Met Gly Val Ile Pro Ala 
            180                 185                 190         

Val Ile Phe Phe Phe Leu Leu Phe Leu Val Pro Glu Ser Pro Arg Tyr 
        195                 200                 205             

Leu Met Lys Arg Gly Arg Glu Glu Gln Ala Ile Ser Ile Leu Glu Arg 
    210                 215                 220                 

Val Ser Gly Pro Glu Arg Ala Arg Trp Asp Val Glu Glu Ile Arg Lys 
225                 230                 235                 240 

Ser Leu Glu Val Val Pro Asp Ser Leu Phe Gln Glu Leu Ser Arg Pro 
                245                 250                 255     

Gly Ile Arg Lys Ala Leu Gly Ile Gly Val Val Leu Ala Ile Phe Gln 
            260                 265                 270         

Gln Phe Thr Gly Thr Asn Ala Val Gly Tyr Tyr Ala Pro Met Ile Phe 
        275                 280                 285             

Lys Ala Ala Gly Ala Gly Thr Asn Ala Ser Phe Tyr Asp Thr Val Trp 
    290                 295                 300                 

Ile Gly Ala Ile Lys Val Ile Phe Val Ile Val Leu Met Leu Ile Val 
305                 310                 315                 320 

Asp Arg Val Gly Arg Lys Arg Leu Leu Val Trp Asn Gly Met Leu Met 
                325                 330                 335     

Ala Leu Phe Leu Ala Ile Leu Gly Val Ala Phe Ser Leu Pro His Met 
            340                 345                 350         

Ile Thr Trp Leu Val Leu Ala Leu Val Phe Ala His Thr Ile Ala Tyr 
        355                 360                 365             

Glu Leu Ser Trp Gly Gly Gly Val Trp Ile Val Leu Ser Glu Ile Tyr 
    370                 375                 380                 

Pro Thr Ala Ile Arg Gly Arg Ala Met Ala Ile Ala Ser Phe Ala Leu 
385                 390                 395                 400 

Trp Phe Ala Thr Tyr Leu Val Ala Gln Phe Phe Pro Ile Leu Leu Gln 
                405                 410                 415     

Ala Ile Gly Gly Thr Trp Thr Phe Trp Ile Phe Ala Leu Phe Cys Ile 
            420                 425                 430         

Ala Met Ala Val Phe Met Gln Arg Val Val Pro Glu Thr Ser Lys Lys 
        435                 440                 445             

Thr Met Glu Lys Ile Gln Ser Asp Trp Leu Gln Ser Glu Arg Gly Ser 
    450                 455                 460                 

Ser Leu 
465     

<210>   180
<211>   466
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   180
Met Met Gln Ala Glu Val Ala Gln Ala Glu Tyr Arg Pro Asn Leu Gly 
                5                   10                  15      

Tyr Val Val Thr Val Val Val Ile Ala Ser Leu Gly Gly Leu Leu Phe 
            20                  25                  30          

Gly Tyr Asp Thr Gly Val Ile Ala Gly Ala Asn Glu Phe Leu Lys Ser 
        35                  40                  45              

Glu Phe His Met Ser Ala Ala Thr Thr Gly Leu Val Ser Ser Ser Ile 
    50                  55                  60                  

Asp Leu Gly Ala Met Leu Gly Val Leu Ile Ala Gly Phe Leu Gly Asp 
65                  70                  75                  80  

Ser Phe Gly Arg Lys Lys Ala Leu Ser Val Ala Gly Ile Ile Phe Ile 
                85                  90                  95      

Ala Ser Ser Leu Ile Ser Ala Phe Ala Pro Ser Val Gly Val Leu Val 
            100                 105                 110         

Leu Gly Arg Phe Ile Gly Gly Val Gly Ile Gly Leu Ala Ser Leu Leu 
        115                 120                 125             

Ser Pro Leu Tyr Ile Ala Glu Ile Ala Pro Pro Arg Ile Arg Gly Arg 
    130                 135                 140                 

Leu Val Gly Ser Asn Gln Leu Ala Ile Val Ser Gly Ile Phe Ile Val 
145                 150                 155                 160 

Tyr Phe Val Asn Ala Ala Ile Val Ser Ser His Thr Thr Ala Trp Asn 
                165                 170                 175     

Gln Thr Thr Gly Trp Arg Trp Met Phe Ala Met Gly Val Ile Pro Ala 
            180                 185                 190         

Val Ile Phe Phe Phe Leu Leu Phe Leu Val Pro Glu Ser Pro Arg Tyr 
        195                 200                 205             

Leu Met Lys Arg Gly Arg Glu Glu Gln Ala Ile Ser Ile Leu Glu Arg 
    210                 215                 220                 

Val Ser Gly Pro Glu Arg Ala Arg Trp Asp Val Glu Glu Ile Arg Lys 
225                 230                 235                 240 

Ser Leu Glu Val Val Pro Asp Ser Leu Phe Gln Glu Leu Ser Arg Pro 
                245                 250                 255     

Gly Ile Arg Lys Ala Leu Gly Ile Gly Val Val Leu Ala Ile Phe Gln 
            260                 265                 270         

Gln Phe Thr Gly Thr Asn Ala Val Gly Tyr Tyr Ala Pro Met Ile Phe 
        275                 280                 285             

Lys Ala Ala Gly Ala Gly Thr Asn Ala Ser Phe Tyr Asp Thr Val Trp 
    290                 295                 300                 

Ile Gly Ala Ile Lys Val Ile Phe Val Leu Val Leu Met Leu Ile Val 
305                 310                 315                 320 

Asp Arg Val Gly Arg Lys Arg Leu Leu Val Trp Asn Gly Met Leu Met 
                325                 330                 335     

Ala Leu Phe Leu Ala Ile Leu Gly Val Ala Phe Ser Leu Pro His Met 
            340                 345                 350         

Ile Thr Trp Leu Val Leu Ala Leu Val Phe Ala His Thr Ile Ala Tyr 
        355                 360                 365             

Glu Leu Ser Trp Gly Gly Gly Val Trp Ile Val Leu Ser Glu Ile Tyr 
    370                 375                 380                 

Pro Thr Ala Ile Arg Gly Arg Ala Met Ala Ile Ala Ser Phe Ala Leu 
385                 390                 395                 400 

Trp Phe Ala Thr Tyr Leu Val Ala Gln Phe Phe Pro Ile Leu Leu Gln 
                405                 410                 415     

Ala Ile Gly Gly Thr Trp Thr Phe Trp Ile Phe Ala Leu Phe Cys Ile 
            420                 425                 430         

Ala Met Ala Val Phe Met Gln Arg Val Val Pro Glu Thr Ser Lys Lys 
        435                 440                 445             

Thr Met Glu Lys Ile Gln Ser Asp Trp Leu Gln Ser Glu Arg Gly Ser 
    450                 455                 460                 

Ser Leu 
465     

<210>   181
<211>   466
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   181
Met Met Gln Ala Glu Val Ala Gln Ala Glu Tyr Arg Pro Asn Leu Gly 
                5                   10                  15      

Tyr Val Val Thr Val Val Val Ile Ala Ser Leu Gly Gly Leu Leu Phe 
            20                  25                  30          

Gly Tyr Asp Thr Gly Val Ile Ala Gly Ala Asn Glu Phe Leu Lys Ser 
        35                  40                  45              

Glu Phe His Met Ser Ala Ala Thr Thr Gly Leu Val Ser Ser Ser Ile 
    50                  55                  60                  

Asp Leu Gly Ala Met Leu Gly Val Leu Ile Ala Gly Phe Leu Gly Asp 
65                  70                  75                  80  

Ser Phe Gly Arg Lys Lys Ala Leu Ser Val Ala Gly Ile Ile Phe Ile 
                85                  90                  95      

Ala Ser Ser Leu Ile Ser Ala Phe Ala Pro Ser Val Gly Val Leu Val 
            100                 105                 110         

Leu Gly Arg Phe Ile Gly Gly Val Gly Ile Gly Leu Ala Ser Leu Leu 
        115                 120                 125             

Ser Pro Leu Tyr Ile Ala Glu Ile Ala Pro Pro Arg Ile Arg Gly Arg 
    130                 135                 140                 

Leu Val Gly Ser Asn Gln Leu Ala Ile Val Ser Gly Ile Phe Ile Val 
145                 150                 155                 160 

Tyr Phe Val Asn Ala Ala Ile Val Ser Ser His Thr Thr Ala Trp Asn 
                165                 170                 175     

Gln Thr Thr Gly Trp Arg Trp Met Phe Ala Met Gly Val Ile Pro Ala 
            180                 185                 190         

Val Ile Phe Phe Phe Leu Leu Phe Leu Val Pro Glu Ser Pro Arg Tyr 
        195                 200                 205             

Leu Met Lys Arg Gly Arg Glu Glu Gln Ala Ile Ser Ile Leu Glu Arg 
    210                 215                 220                 

Val Ser Gly Pro Glu Arg Ala Arg Trp Asp Val Glu Glu Ile Arg Lys 
225                 230                 235                 240 

Ser Leu Glu Val Val Pro Asp Ser Leu Phe Gln Glu Leu Ser Arg Pro 
                245                 250                 255     

Gly Leu Arg Lys Ala Leu Gly Ile Gly Val Val Leu Ala Ile Phe Gln 
            260                 265                 270         

Gln Phe Thr Gly Thr Asn Ala Val Gly Tyr Tyr Ala Pro Met Ile Phe 
        275                 280                 285             

Lys Ala Ala Gly Ala Gly Thr Asn Ala Ser Phe Tyr Asp Thr Val Trp 
    290                 295                 300                 

Ile Gly Ala Ile Lys Val Ile Phe Val Ile Val Leu Met Leu Ile Val 
305                 310                 315                 320 

Asp Arg Val Gly Arg Lys Arg Leu Leu Val Trp Asn Gly Met Leu Met 
                325                 330                 335     

Ala Leu Phe Leu Ala Ile Leu Gly Val Ala Phe Ser Leu Pro His Met 
            340                 345                 350         

Ile Thr Trp Leu Val Leu Ala Leu Val Phe Ala His Thr Ile Ala Tyr 
        355                 360                 365             

Glu Leu Ser Trp Gly Gly Gly Val Trp Ile Val Leu Ser Glu Ile Tyr 
    370                 375                 380                 

Pro Thr Ala Ile Arg Gly Arg Ala Met Ala Ile Ala Ser Phe Ala Leu 
385                 390                 395                 400 

Trp Phe Ala Thr Tyr Leu Val Ala Gln Phe Phe Pro Ile Leu Leu Gln 
                405                 410                 415     

Ala Ile Gly Gly Thr Trp Thr Phe Trp Ile Phe Ala Leu Phe Cys Ile 
            420                 425                 430         

Ala Met Ala Val Phe Met Gln Arg Val Val Pro Glu Thr Ser Lys Lys 
        435                 440                 445             

Thr Met Glu Lys Ile Gln Ser Asp Trp Leu Gln Ser Glu Arg Gly Ser 
    450                 455                 460                 

Ser Leu 
465     

<210>   182
<211>   466
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   182
Met Met Gln Ala Glu Val Ala Gln Ala Glu Tyr Arg Pro Asn Leu Gly 
                5                   10                  15      

Tyr Val Val Thr Val Val Val Ile Ala Ser Leu Gly Gly Leu Leu Phe 
            20                  25                  30          

Gly Tyr Asp Thr Gly Val Ile Ala Gly Ala Asn Glu Phe Leu Lys Ser 
        35                  40                  45              

Glu Phe His Met Ser Ala Ala Thr Thr Gly Leu Val Ser Ser Ser Ile 
    50                  55                  60                  

Asp Leu Gly Ala Met Leu Gly Val Leu Ile Ala Gly Phe Leu Gly Asp 
65                  70                  75                  80  

Ser Phe Gly Arg Lys Lys Ala Leu Ser Val Ala Gly Ile Ile Phe Ile 
                85                  90                  95      

Ala Ser Ser Leu Ile Ser Ala Phe Ala Pro Ser Val Gly Val Leu Val 
            100                 105                 110         

Leu Gly Arg Phe Ile Gly Gly Val Gly Ile Gly Leu Ala Ser Leu Leu 
        115                 120                 125             

Ser Pro Leu Tyr Ile Ala Glu Ile Ala Pro Pro Arg Ile Arg Gly Arg 
    130                 135                 140                 

Leu Val Gly Ser Asn Gln Leu Ala Ile Val Ser Gly Ile Phe Ile Val 
145                 150                 155                 160 

Tyr Phe Val Asn Ala Ala Ile Val Ser Ser His Thr Thr Ala Trp Asn 
                165                 170                 175     

Gln Thr Thr Gly Trp Arg Trp Met Phe Ala Met Gly Val Ile Pro Ala 
            180                 185                 190         

Val Ile Phe Phe Phe Leu Leu Phe Leu Val Pro Glu Ser Pro Arg Tyr 
        195                 200                 205             

Leu Met Lys Arg Gly Arg Glu Glu Gln Ala Ile Ser Ile Leu Glu Arg 
    210                 215                 220                 

Val Ser Gly Pro Glu Arg Ala Arg Trp Asp Val Glu Glu Ile Arg Lys 
225                 230                 235                 240 

Ser Leu Glu Val Val Pro Asp Ser Leu Phe Gln Glu Leu Ser Arg Pro 
                245                 250                 255     

Gly Ile Arg Lys Ala Leu Gly Ile Gly Val Ile Leu Ala Ile Phe Gln 
            260                 265                 270         

Gln Phe Thr Gly Thr Asn Ala Val Gly Tyr Tyr Ala Pro Met Ile Phe 
        275                 280                 285             

Lys Ala Ala Gly Ala Gly Thr Asn Ala Ser Phe Tyr Asp Thr Val Trp 
    290                 295                 300                 

Ile Gly Ala Ile Lys Val Ile Phe Val Ile Val Leu Met Leu Ile Val 
305                 310                 315                 320 

Asp Arg Val Gly Arg Lys Arg Leu Leu Val Trp Asn Gly Met Leu Met 
                325                 330                 335     

Ala Leu Phe Leu Ala Ile Leu Gly Val Ala Phe Ser Leu Pro His Met 
            340                 345                 350         

Ile Thr Trp Leu Val Leu Ala Leu Val Phe Ala His Thr Ile Ala Tyr 
        355                 360                 365             

Glu Leu Ser Trp Gly Gly Gly Val Trp Ile Val Leu Ser Glu Ile Tyr 
    370                 375                 380                 

Pro Thr Ala Ile Arg Gly Arg Ala Met Ala Ile Ala Ser Phe Ala Leu 
385                 390                 395                 400 

Trp Phe Ala Thr Tyr Leu Val Ala Gln Phe Phe Pro Ile Leu Leu Gln 
                405                 410                 415     

Ala Ile Gly Gly Thr Trp Thr Phe Trp Ile Phe Ala Leu Phe Cys Ile 
            420                 425                 430         

Ala Met Ala Val Phe Met Gln Arg Val Val Pro Glu Thr Ser Lys Lys 
        435                 440                 445             

Thr Met Glu Lys Ile Gln Ser Asp Trp Leu Gln Ser Glu Arg Gly Ser 
    450                 455                 460                 

Ser Leu 
465     

<210>   183
<211>   1401
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   183
ttgatgcagg cagaagtggc gcaggccgag tatcggccga atctgggcta cgtcgtgacg       60

gtcgtcgtca ttgcatcgat tggcgggctt ctcttcgggt atgacaccgg cgtgatcgca      120

ggggcgaacg agtttctgaa atcggagttt cacatgagtg cagcgaccac cggactcgtc      180

tcgagcagca tcgatctcgg cgccatgctc ggcgtgctca tcgcgggctt cctgggcgac      240

tcgttcggaa ggaagaaagc gctgtcggtc gcgggcatca tcttcatcgc ctcgagcttg      300

atctcggcct tcgcgccgag cgtcggcgtg ttggttctcg ggcggtttat cgggggcgtc      360

ggcatcggtc tggcgtcgct gttgtcgccg ctctacatcg ccgagatcgc accgccgcgg      420

atccgcgggc gattggtcgg gtcgaaccaa ttggctatcg tgtccgggat tttcatcgtc      480

tactttgtga acgcggctat cgtcagttcg cacaccacgg cctggaacca gacgacgggc      540

tggcgctgga tgtttgccat gggtgtcatt ccggccgtca tctttttctt cctgctcttc      600

cttgtgccgg agagcccgag gtatctcatg aagcggggac gcgaagagca ggccatctcg      660

attctcgaac gcgtgagcgg ccctgagcgg gcgcggtggg acgtcgagga gattcgcaaa      720

tcgctcgaag tcgtgccgga ttcgttgttt caagaactgt cgcgcccggg cattcgaaag      780

gcgctcggca tcggcgtcgt gctcgcgatc ttccaacagt tcacgggcac caacgccgtg      840

ggctattacg ccccgatgat cttcaaggcg gccggcgcag gcaccaacgc gtcgttctac      900

gacacggttt ggattggcgc catcaaggtc atcttcgtca tcgtgctgat gctcatcgtc      960

gatcgcgtcg gaagaaagcg gttgcttgtg tggaacggga tgctcatggc gctctttctc     1020

gccatcctgg gcgtcgcctt ttcactgccg cacatgatca cgtggctggt cctcgcgctt     1080

gtgttcgcgc acaccatcgc ctacgagctg tcctggggcg gcggcgtgtg gattgtgttg     1140

tccgagatct atccgactgc catccgcggc cgcgccatgg ccatcgcgtc ctttgcgctg     1200

tggttcgcca catacctcgt ggcgcagttc ttcccgattt tgttgcaggc tatcggcggc     1260

acgtggacgt tttggatctt cgcgctgttc tgcatcgcca tggccgtctt catgcagcgg     1320

gtcgtgccgg agacgagcaa gaagacgatg gagaagatcc aaagcgactg gctccagtcg     1380

gagcgaggaa gctctctgtg a                                               1401


<210>   184
<211>   1401
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   184
ttgatgcagg cagaagtggc gcaggccgag tatcggccga atctgggcta cgtcgtgacg       60

gtcattgtca ttgcatcgct cggcgggctt ctcttcgggt atgacaccgg cgtgatcgca      120

ggggcgaacg agtttctgaa atcggagttt cacatgagtg cagcgaccac cggactcgtc      180

tcgagcagca tcgatctcgg cgccatgctc ggcgtgctca tcgcgggctt cctgggcgac      240

tcgttcggaa ggaagaaagc gctgtcggtc gcgggcatca tcttcatcgc ctcgagcttg      300

atctcggcct tcgcgccgag cgtcggcgtg ttggttctcg ggcggtttat cgggggcgtc      360

ggcatcggtc tggcgtcgct gttgtcgccg ctctacatcg ccgagatcgc accgccgcgg      420

atccgcgggc gattggtcgg gtcgaaccaa ttggctatcg tgtccgggat tttcatcgtc      480

tactttgtga acgcggctat cgtcagttcg cacaccacgg cctggaacca gacgacgggc      540

tggcgctgga tgtttgccat gggtgtcatt ccggccgtca tctttttctt cctgctcttc      600

cttgtgccgg agagcccgag gtatctcatg aagcggggac gcgaagagca ggccatctcg      660

attctcgaac gcgtgagcgg ccctgagcgg gcgcggtggg acgtcgagga gattcgcaaa      720

tcgctcgaag tcgtgccgga ttcgttgttt caagaactgt cgcgcccggg cattcgaaag      780

gcgctcggca tcggcgtcgt gctcgcgatc ttccaacagt tcacgggcac caacgccgtg      840

ggctattacg ccccgatgat cttcaaggcg gccggcgcag gcaccaacgc gtcgttctac      900

gacacggttt ggattggcgc catcaaggtc atcttcgtca tcgtgctgat gctcatcgtc      960

gatcgcgtcg gaagaaagcg gttgcttgtg tggaacggga tgctcatggc gctctttctc     1020

gccatcctgg gcgtcgcctt ttcactgccg cacatgatca cgtggctggt cctcgcgctt     1080

gtgttcgcgc acaccatcgc ctacgagctg tcctggggcg gcggcgtgtg gattgtgttg     1140

tccgagatct atccgactgc catccgcggc cgcgccatgg ccatcgcgtc ctttgcgctg     1200

tggttcgcca catacctcgt ggcgcagttc ttcccgattt tgttgcaggc tatcggcggc     1260

acgtggacgt tttggatctt cgcgctgttc tgcatcgcca tggccgtctt catgcagcgg     1320

gtcgtgccgg agacgagcaa gaagacgatg gagaagatcc aaagcgactg gctccagtcg     1380

gagcgaggaa gctctctgtg a                                               1401


<210>   185
<211>   1401
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   185
ttgatgcagg cagaagtggc gcaggccgag tatcggccga atctgggcta cgtcgtgacg       60

gtcgtcgtca ttgcatcgct cggcgggctt ctcttcgggt atgacaccgg cgtgatcgca      120

ggggcgaacg agtttctgaa atcggagttt cacatgagtg cagcgaccac cggactcgtc      180

tcgagcagca tcgatctcgg cgccatgctc ggcgtgctca tcgcgggctt cctgggcgac      240

tcgttcggaa ggaagaaagc gctgtcggtc gcgggcatca tcttcatcgc ctcgagcttg      300

atctcggcct tcgcgccgag cgtcggcgtg ttggttctcg ggcggtttat cgggggcgtc      360

ggcatcggtc tggcgtcgct gttgtcgccg ctctacatcg ccgagatcgc accgccgcgg      420

atccgcgggc gattggtcgg gtcgaaccaa ttggctatcg tgtccgggat tttcatcgtc      480

tactttgtga acgcggctat cgtcagttcg cacaccacgg cctggaacca gacgacgggc      540

tggcgctgga tgtttgccat gggtgtcatt ccggccgtca tctttttctt cctgctcttc      600

cttgtgccgg agagcccgag gtatctcatg aagcggggac gcgaagagca ggccatctcg      660

attctcgaac gcgtgagcgg ccctgagcgg gcgcggtggg acgtcgagga gattcgcaaa      720

tcgctcgaag tcgtgccgga ttcgttgttt caagaactgt cgcgcccggg cattcgaaag      780

gcgctcggca tcggcgtcgt gctcgcgatc ttccaacagt tcacgggcac caacgccgtg      840

ggctattacg ccccgatgat cttcaaggcg gccggcgcag gcaccaacgc gtcgttctac      900

gacacggttt ggattggcgc catcaaggtc atcttcgtct tagtgctgat gctcatcgtc      960

gatcgcgtcg gaagaaagcg gttgcttgtg tggaacggga tgctcatggc gctctttctc     1020

gccatcctgg gcgtcgcctt ttcactgccg cacatgatca cgtggctggt cctcgcgctt     1080

gtgttcgcgc acaccatcgc ctacgagctg tcctggggcg gcggcgtgtg gattgtgttg     1140

tccgagatct atccgactgc catccgcggc cgcgccatgg ccatcgcgtc ctttgcgctg     1200

tggttcgcca catacctcgt ggcgcagttc ttcccgattt tgttgcaggc tatcggcggc     1260

acgtggacgt tttggatctt cgcgctgttc tgcatcgcca tggccgtctt catgcagcgg     1320

gtcgtgccgg agacgagcaa gaagacgatg gagaagatcc aaagcgactg gctccagtcg     1380

gagcgaggaa gctctctgtg a                                               1401


<210>   186
<211>   1401
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   186
ttgatgcagg cagaagtggc gcaggccgag tatcggccga atctgggcta cgtcgtgacg       60

gtcgtcgtca ttgcatcgct cggcgggctt ctcttcgggt atgacaccgg cgtgatcgca      120

ggggcgaacg agtttctgaa atcggagttt cacatgagtg cagcgaccac cggactcgtc      180

tcgagcagca tcgatctcgg cgccatgctc ggcgtgctca tcgcgggctt cctgggcgac      240

tcgttcggaa ggaagaaagc gctgtcggtc gcgggcatca tcttcatcgc ctcgagcttg      300

atctcggcct tcgcgccgag cgtcggcgtg ttggttctcg ggcggtttat cgggggcgtc      360

ggcatcggtc tggcgtcgct gttgtcgccg ctctacatcg ccgagatcgc accgccgcgg      420

atccgcgggc gattggtcgg gtcgaaccaa ttggctatcg tgtccgggat tttcatcgtc      480

tactttgtga acgcggctat cgtcagttcg cacaccacgg cctggaacca gacgacgggc      540

tggcgctgga tgtttgccat gggtgtcatt ccggccgtca tctttttctt cctgctcttc      600

cttgtgccgg agagcccgag gtatctcatg aagcggggac gcgaagagca ggccatctcg      660

attctcgaac gcgtgagcgg ccctgagcgg gcgcggtggg acgtcgagga gattcgcaaa      720

tcgctcgaag tcgtgccgga ttcgttgttt caagaactgt cgcgcccggg cttacgaaag      780

gcgctcggca tcggcgtcgt gctcgcgatc ttccaacagt tcacgggcac caacgccgtg      840

ggctattacg ccccgatgat cttcaaggcg gccggcgcag gcaccaacgc gtcgttctac      900

gacacggttt ggattggcgc catcaaggtc atcttcgtca tcgtgctgat gctcatcgtc      960

gatcgcgtcg gaagaaagcg gttgcttgtg tggaacggga tgctcatggc gctctttctc     1020

gccatcctgg gcgtcgcctt ttcactgccg cacatgatca cgtggctggt cctcgcgctt     1080

gtgttcgcgc acaccatcgc ctacgagctg tcctggggcg gcggcgtgtg gattgtgttg     1140

tccgagatct atccgactgc catccgcggc cgcgccatgg ccatcgcgtc ctttgcgctg     1200

tggttcgcca catacctcgt ggcgcagttc ttcccgattt tgttgcaggc tatcggcggc     1260

acgtggacgt tttggatctt cgcgctgttc tgcatcgcca tggccgtctt catgcagcgg     1320

gtcgtgccgg agacgagcaa gaagacgatg gagaagatcc aaagcgactg gctccagtcg     1380

gagcgaggaa gctctctgtg a                                               1401


<210>   187
<211>   1401
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   187
ttgatgcagg cagaagtggc gcaggccgag tatcggccga atctgggcta cgtcgtgacg       60

gtcgtcgtca ttgcatcgct cggcgggctt ctcttcgggt atgacaccgg cgtgatcgca      120

ggggcgaacg agtttctgaa atcggagttt cacatgagtg cagcgaccac cggactcgtc      180

tcgagcagca tcgatctcgg cgccatgctc ggcgtgctca tcgcgggctt cctgggcgac      240

tcgttcggaa ggaagaaagc gctgtcggtc gcgggcatca tcttcatcgc ctcgagcttg      300

atctcggcct tcgcgccgag cgtcggcgtg ttggttctcg ggcggtttat cgggggcgtc      360

ggcatcggtc tggcgtcgct gttgtcgccg ctctacatcg ccgagatcgc accgccgcgg      420

atccgcgggc gattggtcgg gtcgaaccaa ttggctatcg tgtccgggat tttcatcgtc      480

tactttgtga acgcggctat cgtcagttcg cacaccacgg cctggaacca gacgacgggc      540

tggcgctgga tgtttgccat gggtgtcatt ccggccgtca tctttttctt cctgctcttc      600

cttgtgccgg agagcccgag gtatctcatg aagcggggac gcgaagagca ggccatctcg      660

attctcgaac gcgtgagcgg ccctgagcgg gcgcggtggg acgtcgagga gattcgcaaa      720

tcgctcgaag tcgtgccgga ttcgttgttt caagaactgt cgcgcccggg cattcgaaag      780

gcgctcggca tcggcgtcat tctcgcgatc ttccaacagt tcacgggcac caacgccgtg      840

ggctattacg ccccgatgat cttcaaggcg gccggcgcag gcaccaacgc gtcgttctac      900

gacacggttt ggattggcgc catcaaggtc atcttcgtca tcgtgctgat gctcatcgtc      960

gatcgcgtcg gaagaaagcg gttgcttgtg tggaacggga tgctcatggc gctctttctc     1020

gccatcctgg gcgtcgcctt ttcactgccg cacatgatca cgtggctggt cctcgcgctt     1080

gtgttcgcgc acaccatcgc ctacgagctg tcctggggcg gcggcgtgtg gattgtgttg     1140

tccgagatct atccgactgc catccgcggc cgcgccatgg ccatcgcgtc ctttgcgctg     1200

tggttcgcca catacctcgt ggcgcagttc ttcccgattt tgttgcaggc tatcggcggc     1260

acgtggacgt tttggatctt cgcgctgttc tgcatcgcca tggccgtctt catgcagcgg     1320

gtcgtgccgg agacgagcaa gaagacgatg gagaagatcc aaagcgactg gctccagtcg     1380

gagcgaggaa gctctctgtg a                                               1401


<210>   188
<211>   446
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   188
Met Glu Ala Lys Pro Met Lys Arg Asp Arg Leu Trp Lys Ser Gly Ala 
                5                   10                  15      

Leu Leu Ala Leu Gly Leu Val Ala Thr Gly Cys Gly Ala Pro Ala Ala 
            20                  25                  30          

Asn Gly Gly Gly Gln Ala Ala Thr Gly Ala Ser Arg Ala Ala Ala Ser 
        35                  40                  45              

Ser Gln Pro Val Thr Ile Thr Phe Trp Tyr Gly Val Gly Thr Thr Leu 
    50                  55                  60                  

Ser Gln Asp Ile Gln Gln Met Val Gln Ala Phe Asn Gln Thr His Pro 
65                  70                  75                  80  

Gly Ile Lys Val Val Ala Thr Tyr Gln Gly Ser Tyr Ser Gly Gly Gly 
                85                  90                  95      

Glu Glu Gln Gln Lys Leu Leu Ala Ala Ile Lys Ala Gly Asp Pro Pro 
            100                 105                 110         

Thr Ile Ala Gln Ile Glu Val His Ala Met Pro Val Phe Ala Ala Ser 
        115                 120                 125             

Gly Gln Leu Leu Asp Leu Thr Asn Leu Met Gln Ser Ser Ser Val Asp 
    130                 135                 140                 

Lys Pro Ser Asn Phe Leu Pro Gly Ile Leu Val Ser Thr Gln Tyr Gln 
145                 150                 155                 160 

Gly Arg Tyr Tyr Ala Val Pro Phe Asn Arg Ser Val Pro Val Leu Tyr 
                165                 170                 175     

Tyr Asn Lys Thr Leu Phe Ala Lys Ala His Ile Ala Ser Pro Pro Ser 
            180                 185                 190         

Asn Trp Ala Gln Leu Ala Ala Asp Ala Lys Lys Leu Thr Ser Gly Ala 
        195                 200                 205             

Gly Ser Asn Lys Ile Tyr Gly Phe Glu Pro Leu Val Asp Trp Trp Pro 
    210                 215                 220                 

Trp Glu Tyr Ala Val Glu Ser Gly Gly Gly Ser Ile Leu Ser Pro Asp 
225                 230                 235                 240 

Leu Lys Arg Ala Thr Phe Asp Gln Pro Pro Ala Leu Ser Ile Leu Glu 
                245                 250                 255     

Thr Glu Gln Ser Leu Val Lys Gln Gly Tyr Ala Lys Val Glu Thr Gly 
            260                 265                 270         

Pro Asn Tyr Trp Asp Leu Met Thr Gln Asp Phe Ile Asn Gly Gln Val 
        275                 280                 285             

Ala Met Asp Ile Asp Ser Ile Gly Ser Ala Gly Lys Val Thr Lys Gly 
    290                 295                 300                 

Val Gly Asp Lys Phe Gln Trp Gly Thr Ala Leu Leu Pro Arg Gly Lys 
305                 310                 315                 320 

Thr Leu Ala Val Pro Pro Gly Gly Gly Asp Leu Ala Ile Phe Lys Asp 
                325                 330                 335     

Ala Thr Pro Ala Gln Gln Lys Ala Ala Trp Thr Phe Ile Gln Trp Trp 
            340                 345                 350         

Thr Ala Pro Lys Gln Ser Val Gln Trp Ser Thr Glu Thr Gly Tyr Leu 
        355                 360                 365             

Pro Val Gln Lys Ala Asp Leu Asn Asp Pro Val Tyr Gln Ala Tyr Leu 
    370                 375                 380                 

Glu Lys His Pro Gln Tyr Arg Thr Ala Ile Glu Glu Leu Gln Tyr Glu 
385                 390                 395                 400 

His Pro Ser Pro Ala Ser Pro Ala Tyr Leu Ala Val Leu Gln Pro Val 
                405                 410                 415     

Gln Gln Ala Leu Gln Gly Ile Phe Asp Glu Gly Lys Pro Val Ala Ala 
            420                 425                 430         

Thr Met His Gln Ala Ala Glu Ala Ala Asp Gln Asn Leu Gly 
        435                 440                 445     

<210>   189
<211>   1341
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   189
ttggaggcga aacccatgaa gcgagatcga ctgtggaaat ccggcgcgct cctggcgctc       60

ggacttgtgg cgacgggatg cggtgcgccc gccgcaaacg gcggcggaca ggcggcgacc      120

ggcgccagcc gggccgcggc atcgagccag cccgtgacca tcaccttctg gtacggcgtc      180

ggcacgacgc tcagccagga cattcagcag atggtgcagg cgttcaacca gacccacccc      240

ggcatcaagg tcgtggcgac ctatcaaggc agctactccg gcggcggcga ggaacagcag      300

aagctgctcg cggccatcaa ggcgggcgat ccgcccacca tcgcacaaat tgaggtgcac      360

gcgatgccgg ttttcgcggc gagcgggcaa ttgctcgacc tcaccaacct gatgcagtct      420

tcgagcgtcg acaagccgtc caacttcctg ccgggcatcc tcgtctcgac ccagtaccag      480

ggccgatact acgcggtgcc cttcaaccgc agcgtgcccg tgctctacta caacaagacg      540

ctcttcgcga aggcgcacat cgcctcgccc ccctcgaact gggcgcagct cgcggcggac      600

gcgaagaagc tcacgagcgg ggccggatcg aacaagatct acggtttcga accgctcgtc      660

gactggtggc cgtgggaata cgcggtggag tcaggcggcg gctccatcct gtcgcccgat      720

ttgaagcgcg ccaccttcga ccagccgccc gcgctctcca tcctcgagac ggagcagtcg      780

ctcgtgaagc agggatacgc caaggtcgag acgggaccga actactggga cctcatgacg      840

caggacttca tcaacggcca agtggccatg gacatcgact ccatcggcag cgcgggcaag      900

gtgacgaagg gcgtgggcga caagttccag tggggcaccg cgctcctgcc gcgcggcaag      960

acgctcgccg tcccgccggg cggtggcgat ctcgccatct tcaaggacgc cacgcccgcg     1020

caacagaagg ccgcgtggac gttcatccag tggtggaccg cgcccaagca gtcggtccaa     1080

tggtccaccg agaccggtta cctgcccgtg cagaaggcgg atctgaacga ccccgtctac     1140

caggcgtacc tcgagaagca cccgcagtac cggaccgcca ttgaggagct ccagtacgag     1200

catccgtcgc cggcgtcccc cgcgtacctg gccgtgctgc agccggtgca acaggcgctg     1260

caaggcatct tcgacgaggg caagcccgtc gcggccacga tgcatcaggc cgcagaggcc     1320

gccgatcaaa acctcggatg a                                               1341


<210>   190
<211>   349
<212>   PRT
<213>   Clostridium difficile 630

<400>   190
Ile Asp Phe Trp Ala Pro Leu Gly Gly Thr Asn Gly Glu Thr Ala Gln 
                5                   10                  15      

Lys Met Val Asp Gln Phe Asn Ser Glu His Lys Asp Val Gln Val Asn 
            20                  25                  30          

Met Leu Lys Gln Lys Asp Tyr Tyr Glu Asn Ala Thr Lys Leu Gln Ala 
        35                  40                  45              

Ala Leu Thr Ser Lys Asp Gln Pro Asp Val Thr Leu Leu Glu Ile Thr 
    50                  55                  60                  

Gln Thr Gly Thr Phe Ala Ser Ala Gly Ala Leu Val Asp Met Ser Lys 
65                  70                  75                  80  

Tyr Phe Asp Lys Thr Tyr Gln Glu Arg Phe Phe Ser Gly Leu Leu Thr 
                85                  90                  95      

Asn Ser Tyr Tyr Glu Asp Lys Phe Val Gly Met Pro Phe Asn Arg Ser 
            100                 105                 110         

Thr Pro Ile Leu Tyr Ile Asn Lys Asp Met Ala Thr Lys Ala Gly Leu 
        115                 120                 125             

Asp Pro Ser Gly Pro Lys Ser Trp Glu Glu Leu Lys Asp Tyr Ala Ser 
    130                 135                 140                 

Lys Met Thr Asn Lys Ser Glu Asp Thr Tyr Gly Phe Glu Thr Pro Ile 
145                 150                 155                 160 

Asp Ile Trp Phe Tyr Glu Ala Met Val Met Gln Ser Gly Gly Glu Ile 
                165                 170                 175     

Thr Asn Gly Lys Lys Val Ala Phe Asn Asn Glu Ala Gly Gln Ala Pro 
            180                 185                 190         

Val Lys Phe Trp Gln Asp Met Met Lys Ala Gly Ile Met Lys Met Pro 
        195                 200                 205             

Pro Gly Glu Asp Tyr Asn Ala Trp Asp Val Ala Lys Gln Asp Phe Val 
    210                 215                 220                 

Asn Gly Lys Val Gly Met Ile Phe Thr Ser Thr Ala Asp Leu Ala Gly 
225                 230                 235                 240 

Leu Met Gln Gln Thr Glu Gly Lys Phe Glu Ile Ser Thr Ala Phe Leu 
                245                 250                 255     

Pro Lys Asn Gln Lys Tyr Ala Thr Pro Thr Gly Gly Ala Asn Leu Val 
            260                 265                 270         

Met Leu Glu Gly Gly Thr Asp Lys Glu Lys Glu Ala Ser Ala Glu Phe 
        275                 280                 285             

Ile Glu Trp Met Thr Gln Thr Asp Lys Ile Val Gln Phe Ser Ser Ser 
    290                 295                 300                 

Thr Gly Tyr Leu Pro Thr Thr Glu Asp Ala Thr Asn Ser Glu Lys Leu 
305                 310                 315                 320 

Gln Thr Leu Tyr Lys Glu Lys Pro Gln Tyr Lys Val Ala Thr Asp Gln 
                325                 330                 335     

Leu Gln Tyr Ala Val Ala Leu Pro Met Leu Asn Gly Tyr 
            340                 345                 

<210>   191
<211>   349
<212>   PRT
<213>   Clostridium difficile QCD-32g58

<400>   191
Ile Asp Phe Trp Ala Pro Leu Gly Gly Thr Asn Gly Glu Thr Ala Gln 
                5                   10                  15      

Lys Met Val Asp Gln Phe Asn Ser Glu His Lys Asp Val Gln Val Asn 
            20                  25                  30          

Met Leu Lys Gln Lys Asp Tyr Tyr Glu Asn Ala Thr Lys Leu Gln Ala 
        35                  40                  45              

Ala Leu Thr Ser Lys Asp Gln Pro Asp Val Thr Leu Leu Glu Ile Thr 
    50                  55                  60                  

Gln Thr Gly Thr Phe Ala Ser Ala Gly Ala Leu Val Asp Met Ser Lys 
65                  70                  75                  80  

Tyr Phe Asp Lys Thr Tyr Gln Glu Arg Phe Phe Ser Gly Leu Leu Thr 
                85                  90                  95      

Asn Ser Tyr Tyr Glu Asp Lys Phe Val Gly Met Pro Phe Asn Arg Ser 
            100                 105                 110         

Thr Pro Ile Leu Tyr Ile Asn Arg Asp Met Ala Thr Lys Ala Gly Leu 
        115                 120                 125             

Asp Pro Ser Gly Pro Lys Ser Trp Glu Glu Leu Lys Asp Tyr Ala Ser 
    130                 135                 140                 

Lys Met Thr Asn Lys Ser Glu Asp Thr Tyr Gly Phe Glu Thr Pro Ile 
145                 150                 155                 160 

Asp Ile Trp Phe Tyr Glu Ala Met Val Met Gln Ser Gly Gly Glu Ile 
                165                 170                 175     

Thr Asn Gly Lys Lys Val Ala Phe Asn Asn Glu Ala Gly Gln Ala Pro 
            180                 185                 190         

Val Lys Phe Trp Gln Asp Met Met Lys Ala Gly Ile Met Lys Met Pro 
        195                 200                 205             

Pro Gly Glu Asp Tyr Asn Ala Trp Asp Val Ala Lys Gln Asp Phe Val 
    210                 215                 220                 

Asn Gly Lys Val Gly Met Ile Phe Thr Ser Thr Ala Asp Leu Ala Gly 
225                 230                 235                 240 

Leu Met Gln Gln Thr Glu Gly Lys Phe Glu Ile Ser Thr Ala Phe Leu 
                245                 250                 255     

Pro Lys Asn Gln Lys Tyr Ala Thr Pro Thr Gly Gly Ala Asn Leu Val 
            260                 265                 270         

Met Leu Glu Gly Gly Thr Asp Lys Glu Lys Glu Ala Ser Ala Glu Phe 
        275                 280                 285             

Ile Glu Trp Met Thr Gln Thr Asp Lys Ile Val Gln Phe Ser Ser Ser 
    290                 295                 300                 

Thr Gly Tyr Leu Pro Thr Thr Glu Asp Ala Thr Asn Ser Glu Lys Leu 
305                 310                 315                 320 

Gln Thr Leu Tyr Lys Glu Lys Pro Gln Tyr Lys Val Ala Thr Asp Gln 
                325                 330                 335     

Leu Gln Tyr Ala Val Ala Leu Pro Met Leu Asn Gly Tyr 
            340                 345                 

<210>   192
<211>   390
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   192
Ile His Ile Lys Tyr Trp Tyr Ala Trp Gly Asp Lys Ile Gly Glu Asn 
                5                   10                  15      

Asn Glu Asn Leu Val Lys Met Phe Asn Glu Ser Gln Asp Lys Ile Tyr 
            20                  25                  30          

Val Glu Ala Glu Tyr Gln Gly Thr Tyr Asp Glu Leu His Ser Lys Thr 
        35                  40                  45              

Gln Ala Ala Phe Ala Ala Lys Asn Ala Pro Glu Val Thr Gln Asn Glu 
    50                  55                  60                  

Ile Ala Ser Ile Gly Val Phe Ala Lys Ser Gly Met Thr Gln Asp Leu 
65                  70                  75                  80  

Thr Pro Phe Val Glu Lys Asp Asp Ile Asn Met Asp Asp Phe Asn Pro 
                85                  90                  95      

Gly Leu Met Gly Asn Ser Tyr Val Asp Asp Lys Leu Tyr Gly Leu Pro 
            100                 105                 110         

Tyr Leu Arg Ser Thr Pro Ile Leu Tyr Met Asn Thr Thr Met Leu Lys 
        115                 120                 125             

Glu Ala Gly Leu Asp Pro Ala Gly Pro Lys Asp Trp Lys Glu Phe Glu 
    130                 135                 140                 

Glu Tyr Leu Thr Ala Leu Thr Lys Glu Gly Lys Thr Val Gly Met Thr 
145                 150                 155                 160 

Met Pro Val Asn Ile Trp Met Tyr Glu Ala Phe Val Ala Gln Gly Glu 
                165                 170                 175     

Gly Gln Met Ile Ser Asp Asp Glu Lys Ser Ala Glu Phe Asn Gly Glu 
            180                 185                 190         

Ala Gly Val Glu Ala Leu Glu Phe Trp Lys Lys Met Ala Asp Lys Gly 
        195                 200                 205             

Val Ile Lys Val Pro Gly Gly Glu Ala Ala Ala Glu Val Ala Lys Gln 
    210                 215                 220                 

Asp Phe Ala Asn Ser Arg Ser Ala Met Ala Phe Ser Ser Thr Ala Asp 
225                 230                 235                 240 

Leu Ser Tyr Asn Leu Ser Val Ala Glu Glu Gln Gly Phe Glu Leu Asn 
                245                 250                 255     

Thr Ala Phe Met Pro Ala Asn Lys Val Asn Gly Val Pro Thr Gly Gly 
            260                 265                 270         

Ala Asn Leu Val Met Thr Ala Gly Leu Asp Glu Glu Arg Gln Asn Ala 
        275                 280                 285             

Ala Trp Glu Phe Ile Lys Trp Met Thr Ala Lys Glu Gln Thr Ile Tyr 
    290                 295                 300                 

Ala Ser Glu Tyr Thr Gly Tyr Leu Pro Ser Arg Leu Ser Ala Val Asp 
305                 310                 315                 320 

Ser Glu Glu Met Lys Ser Leu Tyr Glu Lys Met Pro Gln Phe Lys Val 
                325                 330                 335     

Ala Val Asp Gln Leu Gln Tyr Gly His Ala Arg Pro Met Ala Glu Ala 
            340                 345                 350         

Tyr Pro Glu Val Ala Lys Ile Leu Thr Asp Gln Ile Ser Arg Val Met 
        355                 360                 365             

Leu Glu Asp Gly Leu Ala Pro Lys Asp Ala Leu Asp Glu Ala Ala Glu 
    370                 375                 380                 

Lys Ala Asn Gln Leu Leu 
385                 390 

<210>   193
<211>   350
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   193
Val Lys Val Thr Phe Trp His Ala Met Gly Gly Val Ala Gly Glu Ala 
                5                   10                  15      

Val Gln Arg Leu Val Asp Gln Phe Asn Ser Ser Gln Asp Lys Val Glu 
            20                  25                  30          

Val Glu Ala Val Tyr Gln Gly Thr Tyr Asp Asp Ala Leu Gln Lys Leu 
        35                  40                  45              

Arg Ala Ala Gly Ser Asp Gly Pro Thr Ile Met Gln Val Tyr Glu Ile 
    50                  55                  60                  

Gly Ser Arg Phe Met Ile Asp Ser Gly Met Ile Thr Pro Met Gln Asn 
65                  70                  75                  80  

Phe Val Asp Ala Asp Gly Phe Ser Ile Asp Asp Phe Glu Pro Asn Ile 
                85                  90                  95      

Leu Gly Tyr Tyr Thr Phe Asp Gly Arg Leu Tyr Ser Met Pro Phe Asn 
            100                 105                 110         

Thr Ser Thr Pro Ile Val Tyr Tyr Asn Lys Asp Ala Phe Arg Glu Ala 
        115                 120                 125             

Gly Leu Asp Pro Glu Arg Pro Pro Arg Thr Phe Glu Glu Phe Lys Glu 
    130                 135                 140                 

Tyr Ala Arg Lys Leu Thr Val Thr Gln Gly Gly Glu Thr Arg Tyr Gly 
145                 150                 155                 160 

Ala Ser Ile Ala Leu Tyr Gly Trp Phe Phe Glu Gln Phe Leu Ala Val 
                165                 170                 175     

Gln Gly Ala His Tyr Val Asp Asn Asp Asn Gly Arg Ser Ala Arg Ala 
            180                 185                 190         

Thr Lys Ala Ile Ile Asn Ser Pro Glu Gly Glu Arg Phe Val Thr Trp 
        195                 200                 205             

Leu Lys Glu Met Val Asp Glu Gly Val Ala Ile Asn Leu Gly Arg Arg 
    210                 215                 220                 

Thr Ala Asp Thr Gln Ala Ala Phe Ser Ser Gly Gln Val Ala Met Thr 
225                 230                 235                 240 

Leu Asp Ser Thr Ala Ala Leu Gly Asn Ile Leu Asn Gly Val Gly Asp 
                245                 250                 255     

Lys Phe Glu Ile Gly Thr Ala Phe Leu Pro Arg Pro Glu Gly Ala Ala 
            260                 265                 270         

Glu Gly Gly Val Ile Ile Gly Gly Ala Ser Leu Trp Ile Thr Asn Thr 
        275                 280                 285             

Lys Pro Leu Lys Glu Gln Trp Ala Ala Trp Glu Phe Val Lys Trp Leu 
    290                 295                 300                 

Thr Thr Pro Glu Val Gln Ala Glu Trp Ser Ile Ala Thr Gly Tyr Phe 
305                 310                 315                 320 

Pro Val Arg Lys Ala Ala Tyr Asp Gln Gln Ile Leu Lys Asp Trp His 
                325                 330                 335     

Ala Gln Arg Pro Gln Phe Thr Thr Ala Ile Glu Gln Leu Arg 
            340                 345                 350 

<210>   194
<211>   349
<212>   PRT
<213>   Lactobacillus casei

<400>   194
Val Thr Ile Thr Phe Trp His Gly Met Asn Gly Pro Tyr Gln Lys Ala 
                5                   10                  15      

Leu Asp Gln Ile Ile Asn Asp Phe Asn Lys Ser Gln Lys Gln Tyr Lys 
            20                  25                  30          

Val Val Gly Thr Ala Gln Gly Asn Tyr Thr Ala Leu Gln Gln Lys Ile 
        35                  40                  45              

Met Ala Ala Ala Lys Ser Arg Asn Leu Pro Thr Ile Ala Gln Thr Thr 
    50                  55                  60                  

Tyr Thr Thr Val Pro Asp Tyr Val Lys Asn Gly Phe Ile Ser Pro Leu 
65                  70                  75                  80  

Asp Gln Tyr Met Leu Lys Gly Asp Asp Lys Met Ser Ser Ser Asp Leu 
                85                  90                  95      

Lys Asp Ile Tyr Pro Ala Phe Leu Ser Ser Ser Lys Tyr Gln Gly Lys 
            100                 105                 110         

Tyr Tyr Ser Val Pro Phe Ser Lys Ser Thr Arg Ile Leu Phe Tyr Asn 
        115                 120                 125             

Glu Ala Leu Met Lys Lys Tyr Asn Ile Ala Lys Pro Thr Ser Trp Glu 
    130                 135                 140                 

Asp Ile Lys Lys Asp Ala Asp Lys Leu Lys Ala Asp Gly Ile Ala Ala 
145                 150                 155                 160 

Ile Gly Phe Asp Lys Ser Phe Asp Met Glu Phe Glu Gly Leu Ala Arg 
                165                 170                 175     

Gln Ala Gly Asn Pro Leu Val Ser Ala Asp Pro Leu Lys Ala Asn Leu 
            180                 185                 190         

Asp Ser Lys Lys Thr Leu Thr Ala Ala Asn Phe Ile Met Asp Met Val 
        195                 200                 205             

Asn Ser Gly Glu Ala Lys Thr Ala Gly Glu Asp Ile Tyr Gly Asp Lys 
    210                 215                 220                 

Asn Phe Thr Ala Gly Lys Thr Leu Phe Tyr Ala Gly Ser Ser Ala Gly 
225                 230                 235                 240 

Ile Thr Asn Met Lys Gln Asn Ala Pro Lys Asp Phe Lys Trp Gly Thr 
                245                 250                 255     

Met Pro Leu Pro Ser Tyr Lys Gly Lys Lys Ala Thr Glu Leu Ala Gly 
            260                 265                 270         

Asn Asp Ile Val Leu Phe Lys Ser Ala Ser Ser Asp Lys Gln Lys Gly 
        275                 280                 285             

Ala Trp Ala Phe Met Lys Tyr Leu Leu Ser Glu Lys Glu Thr Ser Lys 
    290                 295                 300                 

Trp Ser Gln Leu Thr Gly Tyr Val Pro Leu Arg Lys Ser Ala Val Lys 
305                 310                 315                 320 

Ser Ala Asp Phe Lys Lys Tyr Leu Ser Ala Asn Pro Thr Ser Gln Ala 
                325                 330                 335     

Ala Val Asp Ser Leu Gly Phe Gly Phe Gln Ser Thr Ala 
            340                 345                 

<210>   195
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   195
Met Glu Ala Lys Pro Met Lys Arg Asp Arg Leu Trp Lys Ser Gly Ala 
                5                   10                  15      

Leu Leu Ala Leu Gly Leu Val Ala Thr Gly Cys Gly Ala Pro Ala Ala 
            20                  25                  30          

Asn Gly Gly Gly Gln Ala Ala Thr Gly Ala Ser Arg Ala Ala Ala Ser 
        35                  40                  45              

Ser Gln Pro Val Thr Ile Thr Phe Trp Tyr Gly Val Gly Thr Thr Leu 
    50                  55                  60                  

Ser Gln Asp Ile Gln Gln Met Val Gln Ala Phe Asn Gln Thr His Pro 
65                  70                  75                  80  

Gly Ile Lys Val Val Ala Thr Tyr Gln Gly Ser Tyr Ser Gly Gly Gly 
                85                  90                  95      

Glu Glu Gln Gln Lys Leu Leu Ala Ala Ile Lys Ala Gly Asp Pro Pro 
            100                 105                 110         

Thr Ile Ala Gln Ile Glu Val His Ala Met Pro Val Phe Ala Ala Ser 
        115                 120                 125             

Gly Gln Leu Leu Asp Leu Thr Asn Leu Met Gln Ser Ser Ser Val Asp 
    130                 135                 140                 

Lys Pro Ser Asn Phe Ile Pro Gly Ile Leu Val Ser Thr Gln Tyr Gln 
145                 150                 155                 160 

Gly Arg Tyr Tyr Ala Val Pro Phe Asn Arg Ser Val Pro Val Leu Tyr 
                165                 170                 175     

Tyr Asn Lys Thr Leu Phe Ala Lys Ala His Ile Ala Ser Pro Pro Ser 
            180                 185                 190         

Asn Trp Ala Gln Leu Ala Ala Asp Ala Lys Lys Leu Thr Ser Gly Ala 
        195                 200                 205             

Gly Ser Asn Lys Ile Tyr Gly Phe Glu Pro Leu Val Asp Trp Trp Pro 
    210                 215                 220                 

Trp Glu Tyr Ala Val Glu Ser Gly Gly Gly Ser Ile Leu Ser Pro Asp 
225                 230                 235                 240 

Leu Lys Arg Ala Thr Phe Asp Gln Pro Pro Ala Leu Ser Ile Leu Glu 
                245                 250                 255     

Thr Glu Gln Ser Leu Val Lys Gln Gly Tyr Ala Lys Val Glu Thr Gly 
            260                 265                 270         

Pro Asn Tyr Trp Asp Leu Met Thr Gln Asp Phe Ile Asn Gly Gln Val 
        275                 280                 285             

Ala Met Asp Ile Asp Ser Ile Gly Ser Ala Gly Lys Val Thr Lys Gly 
    290                 295                 300                 

Val Gly Asp Lys Phe Gln Trp Gly Thr Ala Leu Leu Pro Arg Gly Lys 
305                 310                 315                 320 

Thr Leu Ala Val Pro Pro Gly Gly Gly Asp Leu Ala Ile Phe Lys Asp 
                325                 330                 335     

Ala Thr Pro Ala Gln Gln Lys Ala Ala Trp Thr Phe Ile Gln Trp Trp 
            340                 345                 350         

Thr Ala Pro Lys Gln Ser Val Gln Trp Ser Thr Glu Thr Gly Tyr Leu 
        355                 360                 365             

Pro Val Gln Lys Ala Asp Leu Asn Asp Pro Val Tyr Gln Ala Tyr Leu 
    370                 375                 380                 

Glu Lys His Pro Gln Tyr Arg Thr Ala Ile Glu Glu Leu Gln Tyr Glu 
385                 390                 395                 400 

His Pro Ser Pro Ala Ser Pro Ala Tyr Leu Ala Val Leu Gln Pro Val 
                405                 410                 415     

Gln Gln Ala Leu Gln Gly Ile Phe Asp Glu Gly Lys Pro Val Ala Ala 
            420                 425                 430         

Thr Met His Gln Ala Ala Glu Ala Ala Asp Gln Asn Leu Gly 
        435                 440                 445     

<210>   196
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   196
Met Glu Ala Lys Pro Met Lys Arg Asp Arg Leu Trp Lys Ser Gly Ala 
                5                   10                  15      

Leu Leu Ala Leu Gly Leu Val Ala Thr Gly Cys Gly Ala Pro Ala Ala 
            20                  25                  30          

Asn Gly Gly Gly Gln Ala Ala Thr Gly Ala Ser Arg Ala Ala Ala Ser 
        35                  40                  45              

Ser Gln Pro Val Thr Ile Thr Phe Trp Tyr Gly Val Gly Thr Thr Leu 
    50                  55                  60                  

Ser Gln Asp Ile Gln Gln Met Val Gln Ala Phe Asn Gln Thr His Pro 
65                  70                  75                  80  

Gly Ile Lys Val Val Ala Thr Tyr Gln Gly Ser Tyr Ser Gly Gly Gly 
                85                  90                  95      

Glu Glu Gln Gln Lys Leu Leu Ala Ala Ile Lys Ala Gly Asp Pro Pro 
            100                 105                 110         

Thr Ile Ala Gln Ile Glu Val His Ala Met Pro Val Phe Ala Ala Ser 
        115                 120                 125             

Gly Gln Leu Leu Asp Leu Thr Asn Leu Met Gln Ser Ser Ser Val Asp 
    130                 135                 140                 

Lys Pro Ser Asn Phe Leu Pro Gly Ile Leu Val Ser Thr Gln Tyr Gln 
145                 150                 155                 160 

Gly Arg Tyr Tyr Ala Val Pro Phe Asn Arg Ser Val Pro Val Leu Tyr 
                165                 170                 175     

Tyr Asn Lys Thr Leu Phe Ala Lys Ala His Ile Ala Ser Pro Pro Ser 
            180                 185                 190         

Asn Trp Ala Gln Leu Ala Ala Asp Ala Lys Lys Leu Thr Ser Gly Ala 
        195                 200                 205             

Gly Ser Asn Lys Ile Tyr Gly Phe Glu Pro Leu Val Asp Trp Trp Pro 
    210                 215                 220                 

Trp Glu Tyr Ala Val Glu Ser Gly Gly Gly Ser Ile Leu Ser Pro Asp 
225                 230                 235                 240 

Leu Lys Arg Ala Thr Phe Asp Gln Pro Pro Ala Leu Ser Ile Leu Glu 
                245                 250                 255     

Thr Glu Gln Ser Leu Val Lys Gln Gly Tyr Ala Lys Val Glu Thr Gly 
            260                 265                 270         

Pro Asn Tyr Trp Asp Leu Met Thr Gln Asp Phe Ile Asn Gly Gln Val 
        275                 280                 285             

Ala Met Asp Ile Asp Ser Ile Gly Ser Ala Gly Lys Val Thr Lys Gly 
    290                 295                 300                 

Val Gly Asp Lys Phe Gln Trp Gly Thr Ala Leu Leu Pro Arg Gly Lys 
305                 310                 315                 320 

Thr Leu Ala Val Pro Pro Gly Gly Gly Asp Leu Ala Ile Phe Lys Asp 
                325                 330                 335     

Ala Thr Pro Ala Gln Gln Lys Ala Ala Trp Thr Phe Ile Gln Trp Trp 
            340                 345                 350         

Thr Ala Pro Lys Gln Ser Val Gln Trp Ser Thr Glu Thr Gly Tyr Leu 
        355                 360                 365             

Pro Val Gln Lys Ala Asp Leu Asn Asp Pro Val Tyr Gln Ala Tyr Leu 
    370                 375                 380                 

Glu Lys His Pro Gln Tyr Arg Thr Ala Ile Glu Glu Leu Gln Tyr Glu 
385                 390                 395                 400 

His Pro Ser Pro Ala Ser Pro Ala Tyr Ile Ala Val Leu Gln Pro Val 
                405                 410                 415     

Gln Gln Ala Leu Gln Gly Ile Phe Asp Glu Gly Lys Pro Val Ala Ala 
            420                 425                 430         

Thr Met His Gln Ala Ala Glu Ala Ala Asp Gln Asn Leu Gly 
        435                 440                 445     

<210>   197
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   197
Met Glu Ala Lys Pro Met Lys Arg Asp Arg Leu Trp Lys Ser Gly Ala 
                5                   10                  15      

Leu Leu Ala Leu Gly Leu Val Ala Thr Gly Cys Gly Ala Pro Ala Ala 
            20                  25                  30          

Asn Gly Gly Gly Gln Ala Ala Thr Gly Ala Ser Arg Ala Ala Ala Ser 
        35                  40                  45              

Ser Gln Pro Val Thr Ile Thr Phe Trp Tyr Gly Val Gly Thr Thr Leu 
    50                  55                  60                  

Ser Gln Asp Ile Gln Gln Met Val Gln Ala Phe Asn Gln Thr His Pro 
65                  70                  75                  80  

Gly Ile Lys Val Val Ala Thr Tyr Gln Gly Ser Tyr Ser Gly Gly Gly 
                85                  90                  95      

Glu Glu Gln Gln Lys Leu Leu Ala Ala Ile Lys Ala Gly Asp Pro Pro 
            100                 105                 110         

Thr Ile Ala Gln Ile Glu Val His Ala Met Pro Val Phe Ala Ala Ser 
        115                 120                 125             

Gly Gln Leu Leu Asp Leu Thr Asn Leu Met Gln Ser Ser Ser Val Asp 
    130                 135                 140                 

Lys Pro Ser Asn Phe Leu Pro Gly Ile Ile Val Ser Thr Gln Tyr Gln 
145                 150                 155                 160 

Gly Arg Tyr Tyr Ala Val Pro Phe Asn Arg Ser Val Pro Val Leu Tyr 
                165                 170                 175     

Tyr Asn Lys Thr Leu Phe Ala Lys Ala His Ile Ala Ser Pro Pro Ser 
            180                 185                 190         

Asn Trp Ala Gln Leu Ala Ala Asp Ala Lys Lys Leu Thr Ser Gly Ala 
        195                 200                 205             

Gly Ser Asn Lys Ile Tyr Gly Phe Glu Pro Leu Val Asp Trp Trp Pro 
    210                 215                 220                 

Trp Glu Tyr Ala Val Glu Ser Gly Gly Gly Ser Ile Leu Ser Pro Asp 
225                 230                 235                 240 

Leu Lys Arg Ala Thr Phe Asp Gln Pro Pro Ala Leu Ser Ile Leu Glu 
                245                 250                 255     

Thr Glu Gln Ser Leu Val Lys Gln Gly Tyr Ala Lys Val Glu Thr Gly 
            260                 265                 270         

Pro Asn Tyr Trp Asp Leu Met Thr Gln Asp Phe Ile Asn Gly Gln Val 
        275                 280                 285             

Ala Met Asp Ile Asp Ser Ile Gly Ser Ala Gly Lys Val Thr Lys Gly 
    290                 295                 300                 

Val Gly Asp Lys Phe Gln Trp Gly Thr Ala Leu Leu Pro Arg Gly Lys 
305                 310                 315                 320 

Thr Leu Ala Val Pro Pro Gly Gly Gly Asp Leu Ala Ile Phe Lys Asp 
                325                 330                 335     

Ala Thr Pro Ala Gln Gln Lys Ala Ala Trp Thr Phe Ile Gln Trp Trp 
            340                 345                 350         

Thr Ala Pro Lys Gln Ser Val Gln Trp Ser Thr Glu Thr Gly Tyr Leu 
        355                 360                 365             

Pro Val Gln Lys Ala Asp Leu Asn Asp Pro Val Tyr Gln Ala Tyr Leu 
    370                 375                 380                 

Glu Lys His Pro Gln Tyr Arg Thr Ala Ile Glu Glu Leu Gln Tyr Glu 
385                 390                 395                 400 

His Pro Ser Pro Ala Ser Pro Ala Tyr Leu Ala Val Leu Gln Pro Val 
                405                 410                 415     

Gln Gln Ala Leu Gln Gly Ile Phe Asp Glu Gly Lys Pro Val Ala Ala 
            420                 425                 430         

Thr Met His Gln Ala Ala Glu Ala Ala Asp Gln Asn Leu Gly 
        435                 440                 445     

<210>   198
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   198
Met Glu Ala Lys Pro Met Lys Arg Asp Arg Leu Trp Lys Ser Gly Ala 
                5                   10                  15      

Leu Leu Ala Leu Gly Leu Val Ala Thr Gly Cys Gly Ala Pro Ala Ala 
            20                  25                  30          

Asn Gly Gly Gly Gln Ala Ala Thr Gly Ala Ser Arg Ala Ala Ala Ser 
        35                  40                  45              

Ser Gln Pro Val Thr Ile Thr Phe Trp Tyr Gly Val Gly Thr Thr Leu 
    50                  55                  60                  

Ser Gln Asp Ile Gln Gln Met Val Gln Ala Phe Asn Gln Thr His Pro 
65                  70                  75                  80  

Gly Ile Lys Val Val Ala Thr Tyr Gln Gly Ser Tyr Ser Gly Gly Gly 
                85                  90                  95      

Glu Glu Gln Gln Lys Leu Leu Ala Ala Ile Lys Ala Gly Asp Pro Pro 
            100                 105                 110         

Thr Ile Ala Gln Ile Glu Val His Ala Met Pro Val Phe Ala Ala Ser 
        115                 120                 125             

Gly Gln Leu Leu Asp Leu Thr Asn Leu Met Gln Ser Ser Ser Val Asp 
    130                 135                 140                 

Lys Pro Ser Asn Phe Leu Pro Gly Ile Leu Val Ser Thr Gln Tyr Gln 
145                 150                 155                 160 

Gly Arg Tyr Tyr Ala Val Pro Phe Asn Arg Ser Val Pro Val Leu Tyr 
                165                 170                 175     

Tyr Asn Lys Thr Leu Phe Ala Lys Ala His Ile Ala Ser Pro Pro Ser 
            180                 185                 190         

Asn Trp Ala Gln Leu Ala Ala Asp Ala Lys Lys Leu Thr Ser Gly Ala 
        195                 200                 205             

Gly Ser Asn Lys Ile Tyr Gly Phe Glu Pro Leu Val Asp Trp Trp Pro 
    210                 215                 220                 

Trp Glu Tyr Ala Val Glu Ser Gly Gly Gly Ser Ile Leu Ser Pro Asp 
225                 230                 235                 240 

Leu Lys Arg Ala Thr Phe Asp Gln Pro Pro Ala Leu Ser Ile Leu Glu 
                245                 250                 255     

Thr Glu Gln Ser Leu Val Lys Gln Gly Tyr Ala Lys Val Glu Thr Gly 
            260                 265                 270         

Pro Asn Tyr Trp Asp Leu Met Thr Gln Asp Phe Ile Asn Gly Gln Val 
        275                 280                 285             

Ala Met Asp Ile Asp Ser Ile Gly Ser Ala Gly Lys Val Thr Lys Gly 
    290                 295                 300                 

Val Gly Asp Arg Phe Gln Trp Gly Thr Ala Leu Leu Pro Arg Gly Lys 
305                 310                 315                 320 

Thr Leu Ala Val Pro Pro Gly Gly Gly Asp Leu Ala Ile Phe Lys Asp 
                325                 330                 335     

Ala Thr Pro Ala Gln Gln Lys Ala Ala Trp Thr Phe Ile Gln Trp Trp 
            340                 345                 350         

Thr Ala Pro Lys Gln Ser Val Gln Trp Ser Thr Glu Thr Gly Tyr Leu 
        355                 360                 365             

Pro Val Gln Lys Ala Asp Leu Asn Asp Pro Val Tyr Gln Ala Tyr Leu 
    370                 375                 380                 

Glu Lys His Pro Gln Tyr Arg Thr Ala Ile Glu Glu Leu Gln Tyr Glu 
385                 390                 395                 400 

His Pro Ser Pro Ala Ser Pro Ala Tyr Leu Ala Val Leu Gln Pro Val 
                405                 410                 415     

Gln Gln Ala Leu Gln Gly Ile Phe Asp Glu Gly Lys Pro Val Ala Ala 
            420                 425                 430         

Thr Met His Gln Ala Ala Glu Ala Ala Asp Gln Asn Leu Gly 
        435                 440                 445     

<210>   199
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   199
Met Glu Ala Lys Pro Met Lys Arg Asp Arg Leu Trp Lys Ser Gly Ala 
                5                   10                  15      

Leu Leu Ala Leu Gly Leu Val Ala Thr Gly Cys Gly Ala Pro Ala Ala 
            20                  25                  30          

Asn Gly Gly Gly Gln Ala Ala Thr Gly Ala Ser Arg Ala Ala Ala Ser 
        35                  40                  45              

Ser Gln Pro Val Thr Ile Thr Phe Trp Tyr Gly Val Gly Thr Thr Leu 
    50                  55                  60                  

Ser Gln Asp Ile Gln Gln Met Val Gln Ala Phe Asn Gln Thr His Pro 
65                  70                  75                  80  

Gly Ile Lys Val Val Ala Thr Tyr Gln Gly Ser Tyr Ser Gly Gly Gly 
                85                  90                  95      

Glu Glu Gln Gln Lys Leu Leu Ala Ala Ile Lys Ala Gly Asp Pro Pro 
            100                 105                 110         

Thr Ile Ala Gln Ile Glu Val His Ala Met Pro Val Phe Ala Ala Ser 
        115                 120                 125             

Gly Gln Leu Leu Asp Leu Thr Asn Leu Met Gln Ser Ser Ser Val Asp 
    130                 135                 140                 

Lys Pro Ser Asn Phe Leu Pro Gly Ile Leu Val Ser Thr Gln Tyr Gln 
145                 150                 155                 160 

Gly Arg Tyr Tyr Ala Ile Pro Phe Asn Arg Ser Val Pro Val Leu Tyr 
                165                 170                 175     

Tyr Asn Lys Thr Leu Phe Ala Lys Ala His Ile Ala Ser Pro Pro Ser 
            180                 185                 190         

Asn Trp Ala Gln Leu Ala Ala Asp Ala Lys Lys Leu Thr Ser Gly Ala 
        195                 200                 205             

Gly Ser Asn Lys Ile Tyr Gly Phe Glu Pro Leu Val Asp Trp Trp Pro 
    210                 215                 220                 

Trp Glu Tyr Ala Val Glu Ser Gly Gly Gly Ser Ile Leu Ser Pro Asp 
225                 230                 235                 240 

Leu Lys Arg Ala Thr Phe Asp Gln Pro Pro Ala Leu Ser Ile Leu Glu 
                245                 250                 255     

Thr Glu Gln Ser Leu Val Lys Gln Gly Tyr Ala Lys Val Glu Thr Gly 
            260                 265                 270         

Pro Asn Tyr Trp Asp Leu Met Thr Gln Asp Phe Ile Asn Gly Gln Val 
        275                 280                 285             

Ala Met Asp Ile Asp Ser Ile Gly Ser Ala Gly Lys Val Thr Lys Gly 
    290                 295                 300                 

Val Gly Asp Lys Phe Gln Trp Gly Thr Ala Leu Leu Pro Arg Gly Lys 
305                 310                 315                 320 

Thr Leu Ala Val Pro Pro Gly Gly Gly Asp Leu Ala Ile Phe Lys Asp 
                325                 330                 335     

Ala Thr Pro Ala Gln Gln Lys Ala Ala Trp Thr Phe Ile Gln Trp Trp 
            340                 345                 350         

Thr Ala Pro Lys Gln Ser Val Gln Trp Ser Thr Glu Thr Gly Tyr Leu 
        355                 360                 365             

Pro Val Gln Lys Ala Asp Leu Asn Asp Pro Val Tyr Gln Ala Tyr Leu 
    370                 375                 380                 

Glu Lys His Pro Gln Tyr Arg Thr Ala Ile Glu Glu Leu Gln Tyr Glu 
385                 390                 395                 400 

His Pro Ser Pro Ala Ser Pro Ala Tyr Leu Ala Val Leu Gln Pro Val 
                405                 410                 415     

Gln Gln Ala Leu Gln Gly Ile Phe Asp Glu Gly Lys Pro Val Ala Ala 
            420                 425                 430         

Thr Met His Gln Ala Ala Glu Ala Ala Asp Gln Asn Leu Gly 
        435                 440                 445     

<210>   200
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   200
ttggaggcga aacccatgaa gcgagatcga ctgtggaaat ccggcgcgct cctggcgctc       60

ggacttgtgg cgacgggatg cggtgcgccc gccgcaaacg gcggcggaca ggcggcgacc      120

ggcgccagcc gggccgcggc atcgagccag cccgtgacca tcaccttctg gtacggcgtc      180

ggcacgacgc tcagccagga cattcagcag atggtgcagg cgttcaacca gacccacccc      240

ggcatcaagg tcgtggcgac ctatcaaggc agctactccg gcggcggcga ggaacagcag      300

aagctgctcg cggccatcaa ggcgggcgat ccgcccacca tcgcacaaat tgaggtgcac      360

gcgatgccgg ttttcgcggc gagcgggcaa ttgctcgacc tcaccaacct gatgcagtct      420

tcgagcgtcg acaagccgtc caacttcatt ccgggcatcc tcgtctcgac ccagtaccag      480

ggccgatact acgcggtgcc cttcaaccgc agcgtgcccg tgctctacta caacaagacg      540

ctcttcgcga aggcgcacat cgcctcgccc ccctcgaact gggcgcagct cgcggcggac      600

gcgaagaagc tcacgagcgg ggccggatcg aacaagatct acggtttcga accgctcgtc      660

gactggtggc cgtgggaata cgcggtggag tcaggcggcg gctccatcct gtcgcccgat      720

ttgaagcgcg ccaccttcga ccagccgccc gcgctctcca tcctcgagac ggagcagtcg      780

ctcgtgaagc agggatacgc caaggtcgag acgggaccga actactggga cctcatgacg      840

caggacttca tcaacggcca agtggccatg gacatcgact ccatcggcag cgcgggcaag      900

gtgacgaagg gcgtgggcga caagttccag tggggcaccg cgctcctgcc gcgcggcaag      960

acgctcgccg tcccgccggg cggtggcgat ctcgccatct tcaaggacgc cacgcccgcg     1020

caacagaagg ccgcgtggac gttcatccag tggtggaccg cgcccaagca gtcggtccaa     1080

tggtccaccg agaccggtta cctgcccgtg cagaaggcgg atctgaacga ccccgtctac     1140

caggcgtacc tcgagaagca cccgcagtac cggaccgcca ttgaggagct ccagtacgag     1200

catccgtcgc cggcgtcccc cgcgtacctg gccgtgctgc agccggtgca acaggcgctg     1260

caaggcatct tcgacgaggg caagcccgtc gcggccacga tgcatcaggc cgcagaggcc     1320

gccgatcaaa acctcggatg a                                               1341


<210>   201
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   201
ttggaggcga aacccatgaa gcgagatcga ctgtggaaat ccggcgcgct cctggcgctc       60

ggacttgtgg cgacgggatg cggtgcgccc gccgcaaacg gcggcggaca ggcggcgacc      120

ggcgccagcc gggccgcggc atcgagccag cccgtgacca tcaccttctg gtacggcgtc      180

ggcacgacgc tcagccagga cattcagcag atggtgcagg cgttcaacca gacccacccc      240

ggcatcaagg tcgtggcgac ctatcaaggc agctactccg gcggcggcga ggaacagcag      300

aagctgctcg cggccatcaa ggcgggcgat ccgcccacca tcgcacaaat tgaggtgcac      360

gcgatgccgg ttttcgcggc gagcgggcaa ttgctcgacc tcaccaacct gatgcagtct      420

tcgagcgtcg acaagccgtc caacttcctg ccgggcatcc tcgtctcgac ccagtaccag      480

ggccgatact acgcggtgcc cttcaaccgc agcgtgcccg tgctctacta caacaagacg      540

ctcttcgcga aggcgcacat cgcctcgccc ccctcgaact gggcgcagct cgcggcggac      600

gcgaagaagc tcacgagcgg ggccggatcg aacaagatct acggtttcga accgctcgtc      660

gactggtggc cgtgggaata cgcggtggag tcaggcggcg gctccatcct gtcgcccgat      720

ttgaagcgcg ccaccttcga ccagccgccc gcgctctcca tcctcgagac ggagcagtcg      780

ctcgtgaagc agggatacgc caaggtcgag acgggaccga actactggga cctcatgacg      840

caggacttca tcaacggcca agtggccatg gacatcgact ccatcggcag cgcgggcaag      900

gtgacgaagg gcgtgggcga caagttccag tggggcaccg cgctcctgcc gcgcggcaag      960

acgctcgccg tcccgccggg cggtggcgat ctcgccatct tcaaggacgc cacgcccgcg     1020

caacagaagg ccgcgtggac gttcatccag tggtggaccg cgcccaagca gtcggtccaa     1080

tggtccaccg agaccggtta cctgcccgtg cagaaggcgg atctgaacga ccccgtctac     1140

caggcgtacc tcgagaagca cccgcagtac cggaccgcca ttgaggagct ccagtacgag     1200

catccgtcgc cggcgtcccc cgcgtacatt gccgtgctgc agccggtgca acaggcgctg     1260

caaggcatct tcgacgaggg caagcccgtc gcggccacga tgcatcaggc cgcagaggcc     1320

gccgatcaaa acctcggatg a                                               1341


<210>   202
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   202
ttggaggcga aacccatgaa gcgagatcga ctgtggaaat ccggcgcgct cctggcgctc       60

ggacttgtgg cgacgggatg cggtgcgccc gccgcaaacg gcggcggaca ggcggcgacc      120

ggcgccagcc gggccgcggc atcgagccag cccgtgacca tcaccttctg gtacggcgtc      180

ggcacgacgc tcagccagga cattcagcag atggtgcagg cgttcaacca gacccacccc      240

ggcatcaagg tcgtggcgac ctatcaaggc agctactccg gcggcggcga ggaacagcag      300

aagctgctcg cggccatcaa ggcgggcgat ccgcccacca tcgcacaaat tgaggtgcac      360

gcgatgccgg ttttcgcggc gagcgggcaa ttgctcgacc tcaccaacct gatgcagtct      420

tcgagcgtcg acaagccgtc caacttcctg ccgggcatca ttgtctcgac ccagtaccag      480

ggccgatact acgcggtgcc cttcaaccgc agcgtgcccg tgctctacta caacaagacg      540

ctcttcgcga aggcgcacat cgcctcgccc ccctcgaact gggcgcagct cgcggcggac      600

gcgaagaagc tcacgagcgg ggccggatcg aacaagatct acggtttcga accgctcgtc      660

gactggtggc cgtgggaata cgcggtggag tcaggcggcg gctccatcct gtcgcccgat      720

ttgaagcgcg ccaccttcga ccagccgccc gcgctctcca tcctcgagac ggagcagtcg      780

ctcgtgaagc agggatacgc caaggtcgag acgggaccga actactggga cctcatgacg      840

caggacttca tcaacggcca agtggccatg gacatcgact ccatcggcag cgcgggcaag      900

gtgacgaagg gcgtgggcga caagttccag tggggcaccg cgctcctgcc gcgcggcaag      960

acgctcgccg tcccgccggg cggtggcgat ctcgccatct tcaaggacgc cacgcccgcg     1020

caacagaagg ccgcgtggac gttcatccag tggtggaccg cgcccaagca gtcggtccaa     1080

tggtccaccg agaccggtta cctgcccgtg cagaaggcgg atctgaacga ccccgtctac     1140

caggcgtacc tcgagaagca cccgcagtac cggaccgcca ttgaggagct ccagtacgag     1200

catccgtcgc cggcgtcccc cgcgtacctg gccgtgctgc agccggtgca acaggcgctg     1260

caaggcatct tcgacgaggg caagcccgtc gcggccacga tgcatcaggc cgcagaggcc     1320

gccgatcaaa acctcggatg a                                               1341


<210>   203
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   203
ttggaggcga aacccatgaa gcgagatcga ctgtggaaat ccggcgcgct cctggcgctc       60

ggacttgtgg cgacgggatg cggtgcgccc gccgcaaacg gcggcggaca ggcggcgacc      120

ggcgccagcc gggccgcggc atcgagccag cccgtgacca tcaccttctg gtacggcgtc      180

ggcacgacgc tcagccagga cattcagcag atggtgcagg cgttcaacca gacccacccc      240

ggcatcaagg tcgtggcgac ctatcaaggc agctactccg gcggcggcga ggaacagcag      300

aagctgctcg cggccatcaa ggcgggcgat ccgcccacca tcgcacaaat tgaggtgcac      360

gcgatgccgg ttttcgcggc gagcgggcaa ttgctcgacc tcaccaacct gatgcagtct      420

tcgagcgtcg acaagccgtc caacttcctg ccgggcatcc tcgtctcgac ccagtaccag      480

ggccgatact acgcggtgcc cttcaaccgc agcgtgcccg tgctctacta caacaagacg      540

ctcttcgcga aggcgcacat cgcctcgccc ccctcgaact gggcgcagct cgcggcggac      600

gcgaagaagc tcacgagcgg ggccggatcg aacaagatct acggtttcga accgctcgtc      660

gactggtggc cgtgggaata cgcggtggag tcaggcggcg gctccatcct gtcgcccgat      720

ttgaagcgcg ccaccttcga ccagccgccc gcgctctcca tcctcgagac ggagcagtcg      780

ctcgtgaagc agggatacgc caaggtcgag acgggaccga actactggga cctcatgacg      840

caggacttca tcaacggcca agtggccatg gacatcgact ccatcggcag cgcgggcaag      900

gtgacgaagg gcgtgggcga ccgtttccag tggggcaccg cgctcctgcc gcgcggcaag      960

acgctcgccg tcccgccggg cggtggcgat ctcgccatct tcaaggacgc cacgcccgcg     1020

caacagaagg ccgcgtggac gttcatccag tggtggaccg cgcccaagca gtcggtccaa     1080

tggtccaccg agaccggtta cctgcccgtg cagaaggcgg atctgaacga ccccgtctac     1140

caggcgtacc tcgagaagca cccgcagtac cggaccgcca ttgaggagct ccagtacgag     1200

catccgtcgc cggcgtcccc cgcgtacctg gccgtgctgc agccggtgca acaggcgctg     1260

caaggcatct tcgacgaggg caagcccgtc gcggccacga tgcatcaggc cgcagaggcc     1320

gccgatcaaa acctcggatg a                                               1341


<210>   204
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   204
ttggaggcga aacccatgaa gcgagatcga ctgtggaaat ccggcgcgct cctggcgctc       60

ggacttgtgg cgacgggatg cggtgcgccc gccgcaaacg gcggcggaca ggcggcgacc      120

ggcgccagcc gggccgcggc atcgagccag cccgtgacca tcaccttctg gtacggcgtc      180

ggcacgacgc tcagccagga cattcagcag atggtgcagg cgttcaacca gacccacccc      240

ggcatcaagg tcgtggcgac ctatcaaggc agctactccg gcggcggcga ggaacagcag      300

aagctgctcg cggccatcaa ggcgggcgat ccgcccacca tcgcacaaat tgaggtgcac      360

gcgatgccgg ttttcgcggc gagcgggcaa ttgctcgacc tcaccaacct gatgcagtct      420

tcgagcgtcg acaagccgtc caacttcctg ccgggcatcc tcgtctcgac ccagtaccag      480

ggccgatact acgcgattcc cttcaaccgc agcgtgcccg tgctctacta caacaagacg      540

ctcttcgcga aggcgcacat cgcctcgccc ccctcgaact gggcgcagct cgcggcggac      600

gcgaagaagc tcacgagcgg ggccggatcg aacaagatct acggtttcga accgctcgtc      660

gactggtggc cgtgggaata cgcggtggag tcaggcggcg gctccatcct gtcgcccgat      720

ttgaagcgcg ccaccttcga ccagccgccc gcgctctcca tcctcgagac ggagcagtcg      780

ctcgtgaagc agggatacgc caaggtcgag acgggaccga actactggga cctcatgacg      840

caggacttca tcaacggcca agtggccatg gacatcgact ccatcggcag cgcgggcaag      900

gtgacgaagg gcgtgggcga caagttccag tggggcaccg cgctcctgcc gcgcggcaag      960

acgctcgccg tcccgccggg cggtggcgat ctcgccatct tcaaggacgc cacgcccgcg     1020

caacagaagg ccgcgtggac gttcatccag tggtggaccg cgcccaagca gtcggtccaa     1080

tggtccaccg agaccggtta cctgcccgtg cagaaggcgg atctgaacga ccccgtctac     1140

caggcgtacc tcgagaagca cccgcagtac cggaccgcca ttgaggagct ccagtacgag     1200

catccgtcgc cggcgtcccc cgcgtacctg gccgtgctgc agccggtgca acaggcgctg     1260

caaggcatct tcgacgaggg caagcccgtc gcggccacga tgcatcaggc cgcagaggcc     1320

gccgatcaaa acctcggatg a                                               1341


<210>   205
<211>   311
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   205
Met Ala Lys Ala Ala Glu Ala Val Ile Ala Gln Val Glu Gly Glu Arg 
                5                   10                  15      

Arg Ser Ala Arg Gly Ser Met Ser Leu Gln Ile Thr Gly Leu Ala Met 
            20                  25                  30          

Met Ala Pro Ala Leu Leu Phe Leu Leu Ala Phe Val Phe Val Pro Met 
        35                  40                  45              

Gly Tyr Ala Val Tyr Leu Ser Leu Tyr Gln Ser Thr Leu Tyr Thr Pro 
    50                  55                  60                  

Gln Pro Val Phe Ala Gly Phe Ala Asn Tyr Ala His Leu Leu Ala Ala 
65                  70                  75                  80  

Pro Asp Phe Trp Gln Ala Ala Ser Asn Thr Leu Trp Leu Ala Val Gly 
                85                  90                  95      

Met Met Ala Leu Ser Leu Pro Val Ala Leu Val Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Gln Arg Ile Arg Gly Arg Ala Leu Phe Arg Ala Ala Val Phe Gly 
        115                 120                 125             

Pro Tyr Val Ile Pro Leu Val Ser Ser Gly Leu Ile Phe Ser Leu Leu 
    130                 135                 140                 

Phe Ala Thr Asp Gly Gly Pro Val Asn Leu Ala Leu Gln Arg Leu Gly 
145                 150                 155                 160 

Leu Ser Pro Val Asn Trp Leu Gly Gln Gly Arg Thr Ala Leu Leu Ser 
                165                 170                 175     

Val Leu Ile Leu Thr Ala Trp Gln Phe Thr Gly Tyr Tyr Ala Ile Ile 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Val Pro Thr Ser Leu Met Glu Ala Cys 
        195                 200                 205             

Gln Val Asp Gly Gly Gly Arg Trp Gln Val Phe Arg His Val Thr Leu 
    210                 215                 220                 

Arg Ala Leu Gly Pro Ser Leu Phe Phe Ala Val Val Ile Cys Leu Ile 
225                 230                 235                 240 

Gln Thr Phe Gln Thr Phe Asp Gln Val Tyr Val Met Thr Gly Gly Gly 
                245                 250                 255     

Pro Asp Gly Ala Thr Thr Thr Phe Ala Tyr Tyr Ile Phe Glu Lys Gly 
            260                 265                 270         

Phe Gln Ala Phe Asn Ile Gly Glu Ser Ser Ala Ala Ser Val Ile Leu 
        275                 280                 285             

Ile Leu Val Leu Ala Cys Leu Ser Tyr Leu Gln Met Arg Leu Ser Arg 
    290                 295                 300                 

Arg Trp Val Val Glu Glu Ser 
305                 310     

<210>   206
<211>   936
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   206
gtggccaagg ccgccgaagc cgtgatcgca caggtggaag gggagaggcg ctccgcgcga       60

ggcagcatgt cgcttcaaat caccggcctc gcgatgatgg cgcccgcgct tctcttcctg      120

ctcgcgttcg tgtttgtgcc gatgggctac gcggtgtacc tgagcctgta ccagtcgacg      180

ctgtacaccc cgcaaccggt gttcgccgga ttcgccaact acgcgcacct gcttgccgcg      240

cccgattttt ggcaggcggc gtcgaacacg ctgtggctgg ccgtcggcat gatggcgctg      300

tcgctgcccg tggcccttgt gctcgccctg cttctgaacc agcgcatccg cgggcgggcg      360

ttgttccgcg ccgccgtctt cggcccgtac gtaattccgc tcgtgagctc aggcctcatc      420

ttctcgcttc tcttcgccac ggacggggga ccggtgaatc tggcgcttca gcgcctcggc      480

ctgtcgccgg tcaactggct cggccaaggg cggacggcgc ttctgtccgt gctcatcctc      540

accgcgtggc agttcaccgg ctattacgcc atcatcttcc tcgccggtct gcagagcgtg      600

ccgacgtccc tgatggaggc gtgccaggtg gacggcggcg ggcggtggca ggtatttcgc      660

cacgtgacgc tgcgcgcgct cgggccaagc ctgttcttcg ccgtcgtcat ctgcctcatc      720

cagacgttcc agacctttga tcaggtgtac gtcatgaccg gaggcggtcc agacggcgcg      780

accaccacgt tcgcctatta catcttcgag aaaggctttc aagcgttcaa catcggggag      840

tcttcagcgg cgagcgtcat cctgatcctc gtgctcgcgt gcctctcgta cctgcagatg      900

cgcttgagcc gccgatgggt ggtggaggaa tcgtga                                936


<210>   207
<211>   255
<212>   PRT
<213>   Deinococcus geothermalis DSM 11300

<400>   207
Tyr Ser Leu Tyr Leu Ser Phe Phe Glu Trp Asn Gly Phe Thr Pro Asn 
                5                   10                  15      

Arg Asp Trp Val Gly Gly Gly Asn Tyr Ala Arg Leu Leu Thr Ser Pro 
            20                  25                  30          

Glu Phe Trp Asn Ser Leu Lys Val Thr Ala Leu Tyr Ala Gly Gly Val 
        35                  40                  45              

Thr Leu Thr Ser Leu Ala Leu Gly Leu Leu Val Ala Val Leu Leu Asn 
    50                  55                  60                  

Gln Pro Ile Arg Gly Arg Thr Phe Tyr Arg Val Leu Tyr Phe Leu Pro 
65                  70                  75                  80  

Val Ile Thr Pro Thr Val Ala Ala Gly Val Val Trp Lys Tyr Leu Phe 
                85                  90                  95      

Asp Pro Thr Gln Gly Ala Val Asn Ser Leu Leu Gly Ser Val Gly Leu 
            100                 105                 110         

His Gly Pro Asn Trp Leu Val Asp Pro Lys Trp Ala Leu Leu Ala Val 
        115                 120                 125             

Ile Ile Val Gly Val Trp Lys Arg Val Gly Phe Asn Val Val Val Tyr 
    130                 135                 140                 

Leu Ala Ala Leu Gln Gly Val Pro Arg Ala Tyr Tyr Glu Ala Ala Gln 
145                 150                 155                 160 

Ile Asp Gly Ala Thr Pro Trp Gln Gln Leu Arg Phe Val Thr Val Pro 
                165                 170                 175     

Leu Leu Ala Pro Thr Thr Phe Phe Leu Val Ile Thr Ser Leu Ile Glu 
            180                 185                 190         

Ala Phe Gln Val Phe Asp Leu Val Tyr Val Met Thr Ala Gly Gly Pro 
        195                 200                 205             

Leu Gly Ala Thr Asp Val Phe Gly Phe Tyr Leu Tyr Arg Glu Gly Phe 
    210                 215                 220                 

Lys Tyr Ser Gln Leu Gly Phe Ala Ser Ala Ile Ala Tyr Val Met Phe 
225                 230                 235                 240 

Ala Leu Ile Phe Leu Ala Thr Val Val Gln Phe Arg Phe Thr Arg 
                245                 250                 255 

<210>   208
<211>   251
<212>   PRT
<213>   Anabaena variabilis ATCC 29413

<400>   208
Tyr Leu Phe Tyr Leu Ser Phe Thr Ala Gly Ser Phe Thr Ser Thr Gly 
                5                   10                  15      

Thr Tyr Trp Val Gly Phe Lys Asn Tyr Trp Arg Leu Leu Leu Asn Pro 
            20                  25                  30          

Asp Phe Trp Gln Val Ile Gly Asn Thr Val Tyr Phe Thr Val Ala Ser 
        35                  40                  45              

Val Ile Pro Ser Leu Val Ile Pro Leu Gly Leu Ala Val Leu Leu Asn 
    50                  55                  60                  

Arg Ser Met Ala Leu Arg Gly Val Leu Arg Ser Ala Tyr Phe Leu Pro 
65                  70                  75                  80  

Ser Ile Ile Ser Leu Val Ala Ala Gly Leu Gly Phe Arg Trp Leu Phe 
                85                  90                  95      

Gln Thr Ser Gly Pro Val Asn Ala Phe Leu Asn Ile Phe Gly Ile Pro 
            100                 105                 110         

Ala Ile Ser Trp Leu Gly Asp Thr Phe Trp Ala Met Pro Val Leu Ile 
        115                 120                 125             

Ile Leu Ser Ile Trp Lys Gln Leu Gly Phe Asn Met Val Val Phe Leu 
    130                 135                 140                 

Ala Gly Leu Gln Ala Ile Pro Pro Ser Arg Tyr Glu Ala Ala Glu Leu 
145                 150                 155                 160 

Asp Gly Ala Asn Gly Trp Arg Gln Phe Trp His Ile Thr Leu Pro Gly 
                165                 170                 175     

Leu Arg Pro Thr Leu Ile Phe Ala Thr Val Thr Thr Ala Ile Phe Thr 
            180                 185                 190         

Leu Arg Ser Phe Glu Gln Val Tyr Val Met Thr Gly Gly Gly Pro Leu 
        195                 200                 205             

Asn Thr Thr Asn Leu Leu Val Tyr Tyr Ile Tyr Gln Glu Ala Phe Gly 
    210                 215                 220                 

Gln Phe Asp Phe Gly Tyr Ala Ala Ala Ala Ala Thr Val Leu Leu Ala 
225                 230                 235                 240 

Met Ala Leu Val Leu Val Tyr Leu Gln Leu Arg 
                245                 250     

<210>   209
<211>   251
<212>   PRT
<213>   Nostoc sp. PCC 7120

<400>   209
Tyr Leu Phe Tyr Leu Ser Phe Thr Ala Gly Ser Phe Thr Ser Thr Gly 
                5                   10                  15      

Thr Tyr Trp Val Gly Phe Lys Asn Tyr Trp Arg Leu Leu Leu Asn Pro 
            20                  25                  30          

Asp Phe Trp Gln Val Ile Gly Asn Thr Val Tyr Phe Thr Val Ala Ser 
        35                  40                  45              

Val Ile Pro Ser Leu Val Ile Pro Leu Gly Leu Ala Val Leu Leu Asn 
    50                  55                  60                  

Arg Ser Met Ala Leu Arg Gly Val Leu Arg Ser Ala Tyr Phe Leu Pro 
65                  70                  75                  80  

Ser Ile Ile Ser Leu Val Ala Ala Gly Leu Gly Phe Arg Trp Leu Phe 
                85                  90                  95      

Gln Thr Ser Gly Pro Val Asn Ala Phe Leu Asn Ile Phe Gly Ile Pro 
            100                 105                 110         

Ala Ile Ser Trp Leu Gly Asp Thr Phe Trp Ala Met Pro Val Leu Ile 
        115                 120                 125             

Ile Leu Ser Ile Trp Lys Gln Leu Gly Phe Asn Met Val Val Phe Leu 
    130                 135                 140                 

Ala Gly Leu Gln Ala Ile Pro Pro Ser Arg Tyr Glu Ala Ala Glu Leu 
145                 150                 155                 160 

Asp Gly Ala Asn Gly Trp Arg Gln Phe Trp His Ile Thr Leu Pro Gly 
                165                 170                 175     

Leu Arg Pro Thr Leu Ile Phe Ala Thr Val Thr Thr Ala Ile Phe Thr 
            180                 185                 190         

Leu Arg Ser Phe Glu Gln Val Tyr Val Met Thr Gly Gly Gly Pro Leu 
        195                 200                 205             

Asn Thr Thr Asn Leu Leu Val Tyr Tyr Ile Tyr Gln Glu Ala Phe Gly 
    210                 215                 220                 

Gln Phe Asp Phe Gly Tyr Ala Ala Ala Ala Ala Thr Val Leu Leu Ala 
225                 230                 235                 240 

Met Ala Leu Val Leu Val Tyr Leu Gln Leu Arg 
                245                 250     

<210>   210
<211>   251
<212>   PRT
<213>   Nodularia spumigena CCY9414

<400>   210
Tyr Leu Phe Tyr Leu Ser Phe Thr Ala Gly Ser Phe Thr Ser Ser Gly 
                5                   10                  15      

Thr Thr Trp Val Gly Leu Arg Asn Tyr Trp Arg Leu Leu Leu Thr Pro 
            20                  25                  30          

Asp Phe Trp Gln Val Leu Gly Asn Thr Ile Tyr Phe Thr Val Ala Thr 
        35                  40                  45              

Val Ile Pro Ser Leu Val Ile Pro Leu Ala Leu Ala Val Leu Leu Asp 
    50                  55                  60                  

Lys Ser Leu Ala Leu Arg Gly Leu Leu Arg Ser Ala Tyr Phe Leu Pro 
65                  70                  75                  80  

Ser Ile Ile Ser Leu Val Ala Ala Gly Leu Gly Phe Arg Trp Leu Phe 
                85                  90                  95      

Gln Thr Asp Gly Pro Ala Asn Ala Phe Leu Asp Phe Phe Gly Ile Ala 
            100                 105                 110         

Pro Ile Pro Trp Leu Gly Ser Thr Thr Trp Ala Met Pro Val Leu Ile 
        115                 120                 125             

Val Leu Ser Ile Trp Lys Gln Leu Gly Phe Asn Met Val Val Phe Leu 
    130                 135                 140                 

Ala Gly Leu Gln Ala Ile Pro Pro Ser Arg Tyr Glu Ala Ala Glu Leu 
145                 150                 155                 160 

Asp Gly Ala Asn Ala Trp Gln Gln Phe Trp His Val Thr Leu Pro Gly 
                165                 170                 175     

Leu Gln Pro Thr Met Ile Phe Ala Thr Val Thr Thr Ala Ile Phe Thr 
            180                 185                 190         

Leu Arg Ser Phe Glu Gln Val Tyr Val Ile Thr Gly Gly Gly Pro Leu 
        195                 200                 205             

Asn Ser Thr Asn Leu Leu Val Tyr Tyr Ile Tyr Gln Glu Ala Phe Ala 
    210                 215                 220                 

Gln Phe Asp Phe Gly Tyr Ala Ala Ala Ala Ala Thr Val Leu Leu Ala 
225                 230                 235                 240 

Phe Thr Leu Val Phe Val Tyr Leu Gln Leu Gln 
                245                 250     

<210>   211
<211>   253
<212>   PRT
<213>   Thermus brockianus

<400>   211
Tyr Ser Leu Tyr Leu Ser Phe Leu Asn Thr Arg Val Tyr Pro Trp Arg 
                5                   10                  15      

Leu Glu Val Gly Val Asn Trp Gly Arg Leu Leu Gln Asp Pro Phe Phe 
            20                  25                  30          

Trp Thr Ala Leu Lys Asn Thr Leu Phe Ile Leu Leu Val Gln Val Pro 
        35                  40                  45              

Leu Met Leu Ala Leu Ala Leu Leu Ala Leu Ala Leu Asn Ser Ala Leu 
    50                  55                  60                  

Leu Arg Ala Lys Gly Phe Phe Arg Phe Ala Phe Phe Ala Pro Val Val 
65                  70                  75                  80  

Val Gly Ala Val Ala Tyr Ser Ala Val Phe Arg Leu Leu Phe Asn Thr 
                85                  90                  95      

Glu Phe Gly Ala Val Asn Ala Leu Leu Arg Thr Leu Gly His Pro Gly 
            100                 105                 110         

Tyr Asp Trp Leu Tyr Ala Pro Gly Pro Ala Met Ala Val Ile Ile Ile 
        115                 120                 125             

Ala Leu Thr Trp Arg Trp Thr Gly Tyr Asn Ala Ile Ile Leu Leu Ala 
    130                 135                 140                 

Gly Leu Gln Ser Ile Pro Lys Glu Leu Tyr Glu Ala Ala Ala Leu Asp 
145                 150                 155                 160 

Gly Ala Gly Pro Trp Gln Arg Phe Trp His Val Thr Leu Pro Gly Ile 
                165                 170                 175     

Arg Pro Val Leu Leu Phe Ala Leu Ile Leu Ser Ile Ile Gly Thr Leu 
            180                 185                 190         

Gln Leu Phe Thr Glu Pro Phe Leu Ile Thr Gly Gly Gly Pro Gly Asn 
        195                 200                 205             

Ala Thr Met Thr Leu Gly Val Tyr Leu Tyr Gln Gln Gly Phe Arg Ser 
    210                 215                 220                 

Phe Asn Phe Gly Tyr Ala Ser Ala Ile Ala Tyr Thr Val Ala Leu Leu 
225                 230                 235                 240 

Ala Ala Leu Phe Ser Phe Leu Gln Met Arg Leu Trp Arg 
                245                 250             

<210>   212
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   212
Met Ala Lys Ala Ala Glu Ala Val Ile Ala Gln Val Glu Gly Glu Arg 
                5                   10                  15      

Arg Ser Ala Arg Gly Ser Met Ser Leu Gln Ile Thr Gly Leu Ala Met 
            20                  25                  30          

Met Ala Pro Ala Leu Leu Phe Leu Leu Ala Phe Val Phe Val Pro Met 
        35                  40                  45              

Gly Tyr Ala Val Tyr Leu Ser Leu Tyr Gln Ser Thr Leu Tyr Thr Pro 
    50                  55                  60                  

Gln Pro Val Phe Ala Gly Phe Ala Asn Tyr Ala His Leu Leu Ala Ala 
65                  70                  75                  80  

Pro Asp Phe Trp Gln Ala Ala Ser Asn Thr Leu Trp Leu Ala Val Gly 
                85                  90                  95      

Met Met Ala Leu Ser Leu Pro Val Ala Leu Val Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Gln Arg Ile Arg Gly Arg Ala Leu Phe Arg Ala Ala Val Phe Gly 
        115                 120                 125             

Pro Tyr Val Ile Pro Leu Val Ser Ser Gly Leu Ile Phe Ser Leu Leu 
    130                 135                 140                 

Phe Ala Thr Asp Gly Gly Pro Val Asn Leu Ala Leu Gln Arg Leu Gly 
145                 150                 155                 160 

Leu Ser Pro Val Asn Trp Leu Gly Gln Gly Arg Thr Ala Leu Leu Ser 
                165                 170                 175     

Val Leu Ile Leu Thr Ala Trp Gln Phe Thr Gly Tyr Tyr Ala Ile Ile 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Val Pro Thr Ser Leu Met Glu Ala Cys 
        195                 200                 205             

Gln Val Asp Gly Gly Gly Arg Trp Gln Val Phe Arg His Ile Thr Leu 
    210                 215                 220                 

Arg Ala Leu Gly Pro Ser Leu Phe Phe Ala Val Val Ile Cys Leu Ile 
225                 230                 235                 240 

Gln Thr Phe Gln Thr Phe Asp Gln Val Tyr Val Met Thr Gly Gly Gly 
                245                 250                 255     

Pro Asp Gly Ala Thr Thr Thr Phe Ala Tyr Tyr Ile Phe Glu Lys Gly 
            260                 265                 270         

Phe Gln Ala Phe Asn Ile Gly Glu Ser Ser Ala Ala Ser Val Ile Leu 
        275                 280                 285             

Ile Leu Val Leu Ala Cys Leu Ser Tyr Leu Gln Met Arg Leu Ser Arg 
    290                 295                 300                 

Arg Trp Val Val Glu Glu Ser 
305                 310     

<210>   213
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   213
Met Ala Lys Ala Ala Glu Ala Val Ile Ala Gln Val Glu Gly Glu Arg 
                5                   10                  15      

Arg Ser Ala Arg Gly Ser Met Ser Leu Gln Ile Thr Gly Leu Ala Met 
            20                  25                  30          

Met Ala Pro Ala Leu Leu Phe Leu Leu Ala Phe Val Phe Val Pro Met 
        35                  40                  45              

Gly Tyr Ala Val Tyr Leu Ser Leu Tyr Gln Ser Thr Leu Tyr Thr Pro 
    50                  55                  60                  

Gln Pro Val Phe Ala Gly Phe Ala Asn Tyr Ala His Leu Leu Ala Ala 
65                  70                  75                  80  

Pro Asp Phe Trp Gln Ala Ala Ser Asn Thr Leu Trp Leu Ala Val Gly 
                85                  90                  95      

Met Met Ala Leu Ser Leu Pro Val Ala Leu Val Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Gln Arg Ile Arg Gly Arg Ala Leu Phe Arg Ala Ala Val Phe Gly 
        115                 120                 125             

Pro Tyr Val Ile Pro Leu Val Ser Ser Gly Leu Ile Phe Ser Leu Leu 
    130                 135                 140                 

Phe Ala Thr Asp Gly Gly Pro Val Asn Leu Ala Leu Gln Arg Ile Gly 
145                 150                 155                 160 

Leu Ser Pro Val Asn Trp Leu Gly Gln Gly Arg Thr Ala Leu Leu Ser 
                165                 170                 175     

Val Leu Ile Leu Thr Ala Trp Gln Phe Thr Gly Tyr Tyr Ala Ile Ile 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Val Pro Thr Ser Leu Met Glu Ala Cys 
        195                 200                 205             

Gln Val Asp Gly Gly Gly Arg Trp Gln Val Phe Arg His Val Thr Leu 
    210                 215                 220                 

Arg Ala Leu Gly Pro Ser Leu Phe Phe Ala Val Val Ile Cys Leu Ile 
225                 230                 235                 240 

Gln Thr Phe Gln Thr Phe Asp Gln Val Tyr Val Met Thr Gly Gly Gly 
                245                 250                 255     

Pro Asp Gly Ala Thr Thr Thr Phe Ala Tyr Tyr Ile Phe Glu Lys Gly 
            260                 265                 270         

Phe Gln Ala Phe Asn Ile Gly Glu Ser Ser Ala Ala Ser Val Ile Leu 
        275                 280                 285             

Ile Leu Val Leu Ala Cys Leu Ser Tyr Leu Gln Met Arg Leu Ser Arg 
    290                 295                 300                 

Arg Trp Val Val Glu Glu Ser 
305                 310     

<210>   214
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   214
Met Ala Lys Ala Ala Glu Ala Val Ile Ala Gln Val Glu Gly Glu Arg 
                5                   10                  15      

Arg Ser Ala Arg Gly Ser Met Ser Leu Gln Ile Thr Gly Leu Ala Met 
            20                  25                  30          

Met Ala Pro Ala Leu Leu Phe Leu Leu Ala Phe Val Phe Val Pro Met 
        35                  40                  45              

Gly Tyr Ala Val Tyr Leu Ser Leu Tyr Gln Ser Thr Leu Tyr Thr Pro 
    50                  55                  60                  

Gln Pro Val Phe Ala Gly Phe Ala Asn Tyr Ala His Leu Leu Ala Ala 
65                  70                  75                  80  

Pro Asp Phe Trp Gln Ala Ala Ser Asn Thr Leu Trp Leu Ala Val Gly 
                85                  90                  95      

Met Met Ala Leu Ser Leu Pro Val Ala Leu Val Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Gln Arg Ile Arg Gly Arg Ala Leu Phe Arg Ala Ala Val Phe Gly 
        115                 120                 125             

Pro Tyr Val Ile Pro Leu Val Ser Ser Gly Leu Ile Phe Ser Leu Leu 
    130                 135                 140                 

Phe Ala Thr Asp Gly Gly Pro Val Asn Leu Ala Leu Gln Arg Leu Gly 
145                 150                 155                 160 

Leu Ser Pro Val Asn Trp Leu Gly Gln Gly Arg Thr Ala Leu Leu Ser 
                165                 170                 175     

Val Leu Ile Leu Thr Ala Trp Gln Phe Thr Gly Tyr Tyr Ala Ile Ile 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Ile Pro Thr Ser Leu Met Glu Ala Cys 
        195                 200                 205             

Gln Val Asp Gly Gly Gly Arg Trp Gln Val Phe Arg His Val Thr Leu 
    210                 215                 220                 

Arg Ala Leu Gly Pro Ser Leu Phe Phe Ala Val Val Ile Cys Leu Ile 
225                 230                 235                 240 

Gln Thr Phe Gln Thr Phe Asp Gln Val Tyr Val Met Thr Gly Gly Gly 
                245                 250                 255     

Pro Asp Gly Ala Thr Thr Thr Phe Ala Tyr Tyr Ile Phe Glu Lys Gly 
            260                 265                 270         

Phe Gln Ala Phe Asn Ile Gly Glu Ser Ser Ala Ala Ser Val Ile Leu 
        275                 280                 285             

Ile Leu Val Leu Ala Cys Leu Ser Tyr Leu Gln Met Arg Leu Ser Arg 
    290                 295                 300                 

Arg Trp Val Val Glu Glu Ser 
305                 310     

<210>   215
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   215
Met Ala Lys Ala Ala Glu Ala Val Ile Ala Gln Val Glu Gly Glu Arg 
                5                   10                  15      

Arg Ser Ala Arg Gly Ser Met Ser Leu Gln Ile Thr Gly Leu Ala Met 
            20                  25                  30          

Met Ala Pro Ala Leu Leu Phe Leu Leu Ala Phe Val Phe Val Pro Met 
        35                  40                  45              

Gly Tyr Ala Val Tyr Leu Ser Leu Tyr Asn Ser Thr Leu Tyr Thr Pro 
    50                  55                  60                  

Gln Pro Val Phe Ala Gly Phe Ala Asn Tyr Ala His Leu Leu Ala Ala 
65                  70                  75                  80  

Pro Asp Phe Trp Gln Ala Ala Ser Asn Thr Leu Trp Leu Ala Val Gly 
                85                  90                  95      

Met Met Ala Leu Ser Leu Pro Val Ala Leu Val Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Gln Arg Ile Arg Gly Arg Ala Leu Phe Arg Ala Ala Val Phe Gly 
        115                 120                 125             

Pro Tyr Val Ile Pro Leu Val Ser Ser Gly Leu Ile Phe Ser Leu Leu 
    130                 135                 140                 

Phe Ala Thr Asp Gly Gly Pro Val Asn Leu Ala Leu Gln Arg Leu Gly 
145                 150                 155                 160 

Leu Ser Pro Val Asn Trp Leu Gly Gln Gly Arg Thr Ala Leu Leu Ser 
                165                 170                 175     

Val Leu Ile Leu Thr Ala Trp Gln Phe Thr Gly Tyr Tyr Ala Ile Ile 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Val Pro Thr Ser Leu Met Glu Ala Cys 
        195                 200                 205             

Gln Val Asp Gly Gly Gly Arg Trp Gln Val Phe Arg His Val Thr Leu 
    210                 215                 220                 

Arg Ala Leu Gly Pro Ser Leu Phe Phe Ala Val Val Ile Cys Leu Ile 
225                 230                 235                 240 

Gln Thr Phe Gln Thr Phe Asp Gln Val Tyr Val Met Thr Gly Gly Gly 
                245                 250                 255     

Pro Asp Gly Ala Thr Thr Thr Phe Ala Tyr Tyr Ile Phe Glu Lys Gly 
            260                 265                 270         

Phe Gln Ala Phe Asn Ile Gly Glu Ser Ser Ala Ala Ser Val Ile Leu 
        275                 280                 285             

Ile Leu Val Leu Ala Cys Leu Ser Tyr Leu Gln Met Arg Leu Ser Arg 
    290                 295                 300                 

Arg Trp Val Val Glu Glu Ser 
305                 310     

<210>   216
<211>   311
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   216
Met Ala Lys Ala Ala Glu Ala Val Ile Ala Gln Val Glu Gly Glu Arg 
                5                   10                  15      

Arg Ser Ala Arg Gly Ser Met Ser Leu Gln Ile Thr Gly Leu Ala Met 
            20                  25                  30          

Met Ala Pro Ala Leu Leu Phe Leu Ile Ala Phe Val Phe Val Pro Met 
        35                  40                  45              

Gly Tyr Ala Val Tyr Leu Ser Leu Tyr Gln Ser Thr Leu Tyr Thr Pro 
    50                  55                  60                  

Gln Pro Val Phe Ala Gly Phe Ala Asn Tyr Ala His Leu Leu Ala Ala 
65                  70                  75                  80  

Pro Asp Phe Trp Gln Ala Ala Ser Asn Thr Leu Trp Leu Ala Val Gly 
                85                  90                  95      

Met Met Ala Leu Ser Leu Pro Val Ala Leu Val Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Gln Arg Ile Arg Gly Arg Ala Leu Phe Arg Ala Ala Val Phe Gly 
        115                 120                 125             

Pro Tyr Val Ile Pro Leu Val Ser Ser Gly Leu Ile Phe Ser Leu Leu 
    130                 135                 140                 

Phe Ala Thr Asp Gly Gly Pro Val Asn Leu Ala Leu Gln Arg Leu Gly 
145                 150                 155                 160 

Leu Ser Pro Val Asn Trp Leu Gly Gln Gly Arg Thr Ala Leu Leu Ser 
                165                 170                 175     

Val Leu Ile Leu Thr Ala Trp Gln Phe Thr Gly Tyr Tyr Ala Ile Ile 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Val Pro Thr Ser Leu Met Glu Ala Cys 
        195                 200                 205             

Gln Val Asp Gly Gly Gly Arg Trp Gln Val Phe Arg His Val Thr Leu 
    210                 215                 220                 

Arg Ala Leu Gly Pro Ser Leu Phe Phe Ala Val Val Ile Cys Leu Ile 
225                 230                 235                 240 

Gln Thr Phe Gln Thr Phe Asp Gln Val Tyr Val Met Thr Gly Gly Gly 
                245                 250                 255     

Pro Asp Gly Ala Thr Thr Thr Phe Ala Tyr Tyr Ile Phe Glu Lys Gly 
            260                 265                 270         

Phe Gln Ala Phe Asn Ile Gly Glu Ser Ser Ala Ala Ser Val Ile Leu 
        275                 280                 285             

Ile Leu Val Leu Ala Cys Leu Ser Tyr Leu Gln Met Arg Leu Ser Arg 
    290                 295                 300                 

Arg Trp Val Val Glu Glu Ser 
305                 310     

<210>   217
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   217
gtggccaagg ccgccgaagc cgtgatcgca caggtggaag gggagaggcg ctccgcgcga       60

ggcagcatgt cgcttcaaat caccggcctc gcgatgatgg cgcccgcgct tctcttcctg      120

ctcgcgttcg tgtttgtgcc gatgggctac gcggtgtacc tgagcctgta ccagtcgacg      180

ctgtacaccc cgcaaccggt gttcgccgga ttcgccaact acgcgcacct gcttgccgcg      240

cccgattttt ggcaggcggc gtcgaacacg ctgtggctgg ccgtcggcat gatggcgctg      300

tcgctgcccg tggcccttgt gctcgccctg cttctgaacc agcgcatccg cgggcgggcg      360

ttgttccgcg ccgccgtctt cggcccgtac gtaattccgc tcgtgagctc aggcctcatc      420

ttctcgcttc tcttcgccac ggacggggga ccggtgaatc tggcgcttca gcgcctcggc      480

ctgtcgccgg tcaactggct cggccaaggg cggacggcgc ttctgtccgt gctcatcctc      540

accgcgtggc agttcaccgg ctattacgcc atcatcttcc tcgccggtct gcagagcgtg      600

ccgacgtccc tgatggaggc gtgccaggtg gacggcggcg ggcggtggca ggtatttcgc      660

cacattacgc tgcgcgcgct cgggccaagc ctgttcttcg ccgtcgtcat ctgcctcatc      720

cagacgttcc agacctttga tcaggtgtac gtcatgaccg gaggcggtcc agacggcgcg      780

accaccacgt tcgcctatta catcttcgag aaaggctttc aagcgttcaa catcggggag      840

tcttcagcgg cgagcgtcat cctgatcctc gtgctcgcgt gcctctcgta cctgcagatg      900

cgcttgagcc gccgatgggt ggtggaggaa tcgtga                                936


<210>   218
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   218
gtggccaagg ccgccgaagc cgtgatcgca caggtggaag gggagaggcg ctccgcgcga       60

ggcagcatgt cgcttcaaat caccggcctc gcgatgatgg cgcccgcgct tctcttcctg      120

ctcgcgttcg tgtttgtgcc gatgggctac gcggtgtacc tgagcctgta ccagtcgacg      180

ctgtacaccc cgcaaccggt gttcgccgga ttcgccaact acgcgcacct gcttgccgcg      240

cccgattttt ggcaggcggc gtcgaacacg ctgtggctgg ccgtcggcat gatggcgctg      300

tcgctgcccg tggcccttgt gctcgccctg cttctgaacc agcgcatccg cgggcgggcg      360

ttgttccgcg ccgccgtctt cggcccgtac gtaattccgc tcgtgagctc aggcctcatc      420

ttctcgcttc tcttcgccac ggacggggga ccggtgaatc tggcgcttca gcgcattggc      480

ctgtcgccgg tcaactggct cggccaaggg cggacggcgc ttctgtccgt gctcatcctc      540

accgcgtggc agttcaccgg ctattacgcc atcatcttcc tcgccggtct gcagagcgtg      600

ccgacgtccc tgatggaggc gtgccaggtg gacggcggcg ggcggtggca ggtatttcgc      660

cacgtgacgc tgcgcgcgct cgggccaagc ctgttcttcg ccgtcgtcat ctgcctcatc      720

cagacgttcc agacctttga tcaggtgtac gtcatgaccg gaggcggtcc agacggcgcg      780

accaccacgt tcgcctatta catcttcgag aaaggctttc aagcgttcaa catcggggag      840

tcttcagcgg cgagcgtcat cctgatcctc gtgctcgcgt gcctctcgta cctgcagatg      900

cgcttgagcc gccgatgggt ggtggaggaa tcgtga                                936


<210>   219
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   219
gtggccaagg ccgccgaagc cgtgatcgca caggtggaag gggagaggcg ctccgcgcga       60

ggcagcatgt cgcttcaaat caccggcctc gcgatgatgg cgcccgcgct tctcttcctg      120

ctcgcgttcg tgtttgtgcc gatgggctac gcggtgtacc tgagcctgta ccagtcgacg      180

ctgtacaccc cgcaaccggt gttcgccgga ttcgccaact acgcgcacct gcttgccgcg      240

cccgattttt ggcaggcggc gtcgaacacg ctgtggctgg ccgtcggcat gatggcgctg      300

tcgctgcccg tggcccttgt gctcgccctg cttctgaacc agcgcatccg cgggcgggcg      360

ttgttccgcg ccgccgtctt cggcccgtac gtaattccgc tcgtgagctc aggcctcatc      420

ttctcgcttc tcttcgccac ggacggggga ccggtgaatc tggcgcttca gcgcctcggc      480

ctgtcgccgg tcaactggct cggccaaggg cggacggcgc ttctgtccgt gctcatcctc      540

accgcgtggc agttcaccgg ctattacgcc atcatcttcc tcgccggtct gcagagcatt      600

ccgacgtccc tgatggaggc gtgccaggtg gacggcggcg ggcggtggca ggtatttcgc      660

cacgtgacgc tgcgcgcgct cgggccaagc ctgttcttcg ccgtcgtcat ctgcctcatc      720

cagacgttcc agacctttga tcaggtgtac gtcatgaccg gaggcggtcc agacggcgcg      780

accaccacgt tcgcctatta catcttcgag aaaggctttc aagcgttcaa catcggggag      840

tcttcagcgg cgagcgtcat cctgatcctc gtgctcgcgt gcctctcgta cctgcagatg      900

cgcttgagcc gccgatgggt ggtggaggaa tcgtga                                936


<210>   220
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   220
gtggccaagg ccgccgaagc cgtgatcgca caggtggaag gggagaggcg ctccgcgcga       60

ggcagcatgt cgcttcaaat caccggcctc gcgatgatgg cgcccgcgct tctcttcctg      120

ctcgcgttcg tgtttgtgcc gatgggctac gcggtgtacc tgagcctgta caattcgacg      180

ctgtacaccc cgcaaccggt gttcgccgga ttcgccaact acgcgcacct gcttgccgcg      240

cccgattttt ggcaggcggc gtcgaacacg ctgtggctgg ccgtcggcat gatggcgctg      300

tcgctgcccg tggcccttgt gctcgccctg cttctgaacc agcgcatccg cgggcgggcg      360

ttgttccgcg ccgccgtctt cggcccgtac gtaattccgc tcgtgagctc aggcctcatc      420

ttctcgcttc tcttcgccac ggacggggga ccggtgaatc tggcgcttca gcgcctcggc      480

ctgtcgccgg tcaactggct cggccaaggg cggacggcgc ttctgtccgt gctcatcctc      540

accgcgtggc agttcaccgg ctattacgcc atcatcttcc tcgccggtct gcagagcgtg      600

ccgacgtccc tgatggaggc gtgccaggtg gacggcggcg ggcggtggca ggtatttcgc      660

cacgtgacgc tgcgcgcgct cgggccaagc ctgttcttcg ccgtcgtcat ctgcctcatc      720

cagacgttcc agacctttga tcaggtgtac gtcatgaccg gaggcggtcc agacggcgcg      780

accaccacgt tcgcctatta catcttcgag aaaggctttc aagcgttcaa catcggggag      840

tcttcagcgg cgagcgtcat cctgatcctc gtgctcgcgt gcctctcgta cctgcagatg      900

cgcttgagcc gccgatgggt ggtggaggaa tcgtga                                936


<210>   221
<211>   936
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   221
gtggccaagg ccgccgaagc cgtgatcgca caggtggaag gggagaggcg ctccgcgcga       60

ggcagcatgt cgcttcaaat caccggcctc gcgatgatgg cgcccgcgct tctcttcctg      120

attgcgttcg tgtttgtgcc gatgggctac gcggtgtacc tgagcctgta ccagtcgacg      180

ctgtacaccc cgcaaccggt gttcgccgga ttcgccaact acgcgcacct gcttgccgcg      240

cccgattttt ggcaggcggc gtcgaacacg ctgtggctgg ccgtcggcat gatggcgctg      300

tcgctgcccg tggcccttgt gctcgccctg cttctgaacc agcgcatccg cgggcgggcg      360

ttgttccgcg ccgccgtctt cggcccgtac gtaattccgc tcgtgagctc aggcctcatc      420

ttctcgcttc tcttcgccac ggacggggga ccggtgaatc tggcgcttca gcgcctcggc      480

ctgtcgccgg tcaactggct cggccaaggg cggacggcgc ttctgtccgt gctcatcctc      540

accgcgtggc agttcaccgg ctattacgcc atcatcttcc tcgccggtct gcagagcgtg      600

ccgacgtccc tgatggaggc gtgccaggtg gacggcggcg ggcggtggca ggtatttcgc      660

cacgtgacgc tgcgcgcgct cgggccaagc ctgttcttcg ccgtcgtcat ctgcctcatc      720

cagacgttcc agacctttga tcaggtgtac gtcatgaccg gaggcggtcc agacggcgcg      780

accaccacgt tcgcctatta catcttcgag aaaggctttc aagcgttcaa catcggggag      840

tcttcagcgg cgagcgtcat cctgatcctc gtgctcgcgt gcctctcgta cctgcagatg      900

cgcttgagcc gccgatgggt ggtggaggaa tcgtga                                936


<210>   222
<211>   309
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   222
Met Leu Lys Trp Pro Ser Thr Asp Leu Lys Gly Asn Pro Ser Ile Arg 
                5                   10                  15      

Met Ser Thr Arg Ser Thr Ser Phe Lys Pro Arg Ile Val Phe Glu Thr 
            20                  25                  30          

Pro Ser Pro Gly Leu Leu Thr Ile Trp Trp Arg Thr Arg Lys Val Ser 
        35                  40                  45              

Arg Val Leu Gly Val Gln Arg Met Arg Glu Ile Ile Glu Tyr Arg Pro 
    50                  55                  60                  

Met Leu Thr Ser Leu Val Arg Ser Glu Leu Arg Ala Arg Tyr Lys Gly 
65                  70                  75                  80  

Ser Val Leu Gly Phe Leu Trp Thr Phe Val Asn Pro Leu Leu Gln Leu 
                85                  90                  95      

Ala Val Tyr Ser Leu Val Phe Lys Val Ile Leu Arg Ser Asn Ile Arg 
            100                 105                 110         

Asp Tyr Pro Val Phe Leu Phe Ile Gly Leu Leu Ala Trp Asn Met Phe 
        115                 120                 125             

Thr Gly Ala Leu Gln Ser Ser Cys Gly Val Ile Val Asn Lys Ala Ser 
    130                 135                 140                 

Leu Val Lys Lys Ile Tyr Phe Pro Arg Glu Ile Leu Pro Ala Ser Met 
145                 150                 155                 160 

Ala Gly Thr Ala Leu Val Asn Tyr Val Leu Ser Leu Ala Ile Leu Ile 
                165                 170                 175     

Pro Ile Leu Leu Ile Thr Gly Phe Trp Pro Thr Trp Ser Trp Leu Phe 
            180                 185                 190         

Ala Pro Val Ala Ile Val Ala Ile Phe Phe Met Ala Leu Gly Leu Ser 
        195                 200                 205             

Leu Ile Phe Ser Ala Ile Asn Val Tyr Met Arg Asp Thr Glu His Ile 
    210                 215                 220                 

Leu Asn Ile Val Leu Met Leu Trp Phe Tyr Gly Thr Pro Val Val Tyr 
225                 230                 235                 240 

Ser Ile Asn Ser Val Pro His Phe Leu Ser Ala Leu Phe Lys Val Asp 
                245                 250                 255     

Pro Ile Ala Ala Ala Ile Leu Val Leu Gln Glu Ile Phe Tyr Tyr Arg 
            260                 265                 270         

Glu Ile Pro His Trp Lys Met Leu Ile Tyr Cys Val Val Ser Gly Val 
        275                 280                 285             

Cys Ile Leu Trp Ile Gly Trp Ala Ile Phe Tyr Lys Leu Ser Arg Arg 
    290                 295                 300                 

Phe Ala Glu Glu Val 
305                 

<210>   223
<211>   930
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   223
atgttaaaat ggccgtcgac cgatttgaaa gggaatcctt caattcggat gtctacgaga       60

agtacctcat tcaaaccgag gatagttttc gaaacgccgt cgccaggctt gttgacgatt      120

tggtggcgaa caagaaaggt gagtcgcgtg ttgggcgtgc agcggatgcg cgagatcatt      180

gaataccgac ccatgcttac aagtcttgta cggtcggagc ttcgtgcgcg gtataagggg      240

tcagtcttag gttttctatg gactttcgtg aatccgctct tgcaactcgc ggtgtacagc      300

ctcgtcttca aagtgatctt gcgctctaat attagagact atcctgtatt tctttttatc      360

gggctgctgg catggaacat gttcacagga gcactgcaga gttcttgcgg tgtgattgtc      420

aataaggcat ccttagtcaa gaaaatctac tttcctagag aaattctacc tgcttctatg      480

gccggcacag cacttgtcaa ttatgttctg tcgcttgcta ttctcattcc tatcttgctg      540

attaccggtt tctggccgac ttggagttgg ttattcgcac ctgttgcaat cgtggctatt      600

tttttcatgg cattgggact ctctctaata ttctctgcta tcaatgtata catgagggat      660

accgaacaca tcttgaacat cgtgctgatg ctttggtttt acggaacacc tgtcgtatat      720

tcgatcaact ctgttcccca cttcctttca gctttgttta aagtagatcc gatagcggca      780

gcgatccttg tcttacagga gatcttttat taccgcgaaa tccctcattg gaaaatgttg      840

atatattgtg ttgttagcgg tgtctgcatt ctttggatcg gatgggctat tttctataag      900

ctcagtcgcc ggtttgcgga ggaggtgtga                                       930


<210>   224
<211>   258
<212>   PRT
<213>   Clostridium bolteae ATCC BAA-613

<400>   224
Met Gln Leu Phe Lys Glu Ile Tyr Ala Tyr Arg Glu Met Ile Phe Ser 
                5                   10                  15      

Leu Val Arg Arg Asp Leu Lys Gly Arg Tyr Lys Gly Ser Ala Leu Gly 
            20                  25                  30          

Phe Phe Trp Thr Phe Leu Asn Pro Leu Leu Gln Leu Val Val Tyr Thr 
        35                  40                  45              

Phe Val Phe Ser Val Ile Met Lys Ser Asp Val Glu Tyr Tyr Tyr Leu 
    50                  55                  60                  

His Leu Phe Val Ala Leu Val Pro Trp Leu Phe Phe Ser Met Ser Val 
65                  70                  75                  80  

Ser Glu Gly Cys Ser Cys Ile Arg Ser Gln Gln Asp Met Val Lys Lys 
                85                  90                  95      

Ile Tyr Phe Pro Arg Glu Val Leu Pro Ile Ala Tyr Val Thr Ser Gln 
            100                 105                 110         

Phe Ile Asn Met Leu Leu Ser Phe Val Val Val Leu Leu Val Val Leu 
        115                 120                 125             

Leu Ser Gly Arg Gly Leu Asn Leu Val Ala Leu Leu Tyr Leu Pro Ile 
    130                 135                 140                 

Ile Ala Ile Val Glu Tyr Leu Leu Cys Leu Gly Ser Ala Leu Leu Val 
145                 150                 155                 160 

Ser Ala Ile Thr Val Tyr Val Arg Asp Met Glu Tyr Leu Leu Lys Ile 
                165                 170                 175     

Val Thr Met Ala Leu Gln Phe Leu Thr Pro Val Met Tyr Ser Ile Asp 
            180                 185                 190         

Ile Val Pro Glu Arg Tyr Met Ala Ile Tyr Val Leu Asn Pro Met Thr 
        195                 200                 205             

Pro Ile Ile Val Ala Tyr Arg Asp Ile Leu Tyr Tyr Gly Lys Ile Pro 
    210                 215                 220                 

Arg Leu Thr Thr Leu Leu His Ala Val Leu Met Gly Val Val Leu Leu 
225                 230                 235                 240 

Val Ile Gly Phe Leu Val Phe Gly Lys Leu Lys Arg Arg Phe Ala Glu 
                245                 250                 255     

Glu Leu 
        

<210>   225
<211>   254
<212>   PRT
<213>   Clostridium sp. L2-50

<400>   225
Lys Glu Ile Tyr Asp Tyr Arg Thr Met Ile Val Ser Leu Thr Lys Arg 
                5                   10                  15      

Asp Leu Ile Gly Arg Tyr Lys Arg Ser Val Leu Gly Phe Leu Trp Ser 
            20                  25                  30          

Phe Ile Asp Pro Leu Ile Gln Leu Ala Val Tyr Thr Phe Leu Phe Lys 
        35                  40                  45              

Ile Ile Leu Pro Thr Asn Ile Pro Phe Phe His Ile Cys Leu Phe Val 
    50                  55                  60                  

Ala Leu Val Pro Trp Leu Met Ile Ser Ser Cys Leu Thr Gly Gly Cys 
65                  70                  75                  80  

Met Cys Val Ala Gly Gln Gln Asp Met Ile Lys Lys Ile Tyr Phe Pro 
                85                  90                  95      

Arg Glu Val Leu Pro Ile Ala Phe Val Ser Ala Gln Phe Ile Asn Met 
            100                 105                 110         

Leu Leu Ser Phe Ile Ile Val Phe Val Val Leu Gly Ala Ser Gly Tyr 
        115                 120                 125             

Gly Phe Cys Gly Lys Ala Leu Leu Leu Phe Pro Val Val Val Ile Ile 
    130                 135                 140                 

Glu Tyr Ile Leu Ala Leu Gly Met Thr Leu Phe Phe Ser Ala Val Thr 
145                 150                 155                 160 

Val Tyr Phe Arg Asp Met Gln Gln Ile Leu Gly Ala Leu Ser Leu Ile 
                165                 170                 175     

Leu Met Tyr Ala Ser Pro Ile Ile Tyr Thr Leu Glu Leu Val Pro Glu 
            180                 185                 190         

Lys Tyr Arg Pro Phe Tyr Met Ile Asn Pro Ile Thr Arg Val Ile Val 
        195                 200                 205             

Ala Tyr Arg Asp Ile Phe Tyr Tyr Lys Gln Val Pro Glu Phe Ser Asn 
    210                 215                 220                 

Ile Ile Leu Gly Leu Leu Glu Ser Ile Ile Val Leu Ile Ile Gly Leu 
225                 230                 235                 240 

Val Val Phe Arg Lys Leu Asn Lys His Phe Ala Glu Glu Leu 
                245                 250                 

<210>   226
<211>   258
<212>   PRT
<213>   Stigmatella aurantiaca DW4/3-1

<400>   226
Leu Arg Asn Leu Arg Glu Leu Tyr Gln Tyr Arg Gly Leu Leu Leu Ser 
                5                   10                  15      

Leu Thr Gln Arg Glu Leu Lys Ala Arg Tyr Arg Gly Ser Val Leu Gly 
            20                  25                  30          

Phe Leu Trp Thr Phe Leu Asn Pro Met Leu Gln Met Val Val Tyr Thr 
        35                  40                  45              

Leu Leu Phe Ser Val Tyr Met Arg Gln Gln Ile Glu His Tyr Pro Tyr 
    50                  55                  60                  

Phe Met Phe Val Gly Leu Leu Pro Trp Ile Trp Phe Ser Ser Ser Ile 
65                  70                  75                  80  

Gly Ala Gly Ala Ser Ala Ile Ser Asp Arg Arg Asp Leu Leu Thr Lys 
                85                  90                  95      

Val Arg Phe Pro Ala Gln Val Leu Pro Ala Thr Val Val Val Thr Asn 
            100                 105                 110         

Leu Cys Asn Phe Leu Leu Ser Val Pro Leu Leu Ile Val Phe Gly Leu 
        115                 120                 125             

Val Leu Gly Arg Trp Pro Ser Trp His Leu Leu Phe Phe Pro Val Ile 
    130                 135                 140                 

Val Leu Ile Gln Phe Cys Val Thr Met Gly Leu Ala Tyr Leu Ile Ser 
145                 150                 155                 160 

Ala Ile Asn Val Thr Phe Arg Asp Leu Gln Gln Ile Val Ala Asn Leu 
                165                 170                 175     

Leu Thr Met Trp Phe Phe Val Thr Pro Ile Phe Tyr Arg Thr Ser Thr 
            180                 185                 190         

Val Pro Asp Gln Phe Arg Glu Leu Val Val Leu Ala Asn Pro Met Ala 
        195                 200                 205             

Val Met Val Thr Ser Tyr Gln Ala Ile Phe Tyr Asp His Gln Met Pro 
    210                 215                 220                 

Ala Pro Gly Pro Leu Leu Leu Trp Met Gly Ile Ala Ile Val Leu Met 
225                 230                 235                 240 

Val Val Ala Ser Ser Ile Phe Glu Arg Arg Arg Glu Glu Phe Ala Glu 
                245                 250                 255     

Val Ile 
        

<210>   227
<211>   259
<212>   PRT
<213>   Myxococcus xanthus DK 1622

<400>   227
Ile Arg Leu Val Arg Glu Leu Tyr Gln Tyr Arg Gly Leu Leu Ile Ser 
                5                   10                  15      

Leu Val Gln Arg Glu Leu Lys Ala Arg Tyr Arg Gly Ser Phe Leu Gly 
            20                  25                  30          

Phe Leu Trp Thr Phe Leu Asn Pro Thr Leu His Met Leu Val Tyr Val 
        35                  40                  45              

Leu Leu Phe Thr Val Val Met Arg Gln Asn Ile Pro Asn Phe Pro Phe 
    50                  55                  60                  

Phe Met Phe Val Gly Leu Leu Pro Trp Ile Trp Phe Ser Thr Ser Val 
65                  70                  75                  80  

Gly Gly Gly Ala Ser Ala Ile Ser Asp Arg Arg Asp Leu Leu Thr Lys 
                85                  90                  95      

Val Arg Phe Pro Ala Gln Val Leu Pro Thr Ser Val Val Val Thr Asn 
            100                 105                 110         

Leu Cys Asn Phe Val Leu Ser Leu Pro Leu Met Leu Val Leu Gly Met 
        115                 120                 125             

Ala Tyr Gly Gln Trp Pro Thr Trp His Val Val Leu Phe Pro Val Val 
    130                 135                 140                 

Val Leu Ile Gln Leu Thr Phe Thr Leu Ala Leu Thr Tyr Ile Leu Ala 
145                 150                 155                 160 

Ala Ile Asn Val Thr Phe Arg Asp Leu Gln His Ile Val Ser Asn Leu 
                165                 170                 175     

Leu Thr Leu Trp Phe Phe Ala Thr Pro Val Leu Tyr Pro Leu Ser Thr 
            180                 185                 190         

Ile Gln Asp Glu Ser Ala Arg Ser Leu Met Leu Ala Leu Asn Pro Met 
        195                 200                 205             

Val Ser Leu Met Thr Ser Tyr Gln Ala Ile Phe Tyr Glu His Arg Leu 
    210                 215                 220                 

Pro Asp Ala Glu Pro Leu Met Ala Leu Ala Ala Val Ser Val Val Leu 
225                 230                 235                 240 

Leu Trp Ala Ala Ser Ser Ile Phe Glu Ser Arg Arg Glu Glu Phe Ala 
                245                 250                 255     

Glu Ser Ile 
            

<210>   228
<211>   257
<212>   PRT
<213>   Clostridium acetobutylicum ATCC 824

<400>   228
Ile Asn Ser Ile Lys Glu Ile Leu Lys Tyr Lys Glu Leu Leu Gln Asn 
                5                   10                  15      

Leu Thr Met Lys Glu Leu Lys Leu Lys Tyr Arg Asn Ser Ala Leu Gly 
            20                  25                  30          

Phe Phe Trp Ser Phe Leu Asn Pro Ile Met Leu Leu Ile Val Tyr Thr 
        35                  40                  45              

Phe Ala Phe Lys Tyr Ile Met His Gln Thr Thr Pro Asn Tyr Thr Val 
    50                  55                  60                  

Thr Leu Leu Ala Ala Leu Leu Pro Trp Gln Phe Phe Gln Gly Ala Val 
65                  70                  75                  80  

Gln Gly Ser Thr Thr Ser Ile Ile Ser Asn Ser Asn Leu Ile Lys Lys 
                85                  90                  95      

Ile Tyr Phe Pro Arg Gln Ile Met Pro Leu Ser Ile Ile Phe Ser Asn 
            100                 105                 110         

Phe Val Ser Phe Leu Ile Thr Leu Val Ile Leu Phe Gly Ala Met Ile 
        115                 120                 125             

Val Ser Gln Val Pro Phe Ser Phe Thr Ile Leu Leu Leu Pro Ile Ile 
    130                 135                 140                 

Leu Leu Leu Leu Leu Val Phe Ser Val Gly Leu Ser Leu Ile Leu Ser 
145                 150                 155                 160 

Ser Leu Asn Val Leu Tyr Arg Asp Val Ser His Phe Val Glu Val Leu 
                165                 170                 175     

Phe Met Leu Trp Phe Tyr Leu Thr Pro Ile Val Tyr Val Leu Asp Arg 
            180                 185                 190         

Ile Pro Ile Leu Tyr Lys Asn Ile Leu Leu Ile Asn Pro Met Thr Met 
        195                 200                 205             

Ile Val Glu Cys Ile Arg Ser Val Leu Leu Glu Gly Lys Met Pro Asn 
    210                 215                 220                 

Pro Phe Tyr Ile Val Val Ile Leu Val Trp Asp Ile Val Leu Leu Tyr 
225                 230                 235                 240 

Val Gly Asp Arg Ile Phe Arg Lys Ile Glu Asn Asp Phe Ala Glu Glu 
                245                 250                 255     

Val 
    

<210>   229
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   229
Met Leu Lys Trp Pro Ser Thr Asp Leu Lys Gly Asn Pro Ser Ile Arg 
                5                   10                  15      

Met Ser Thr Arg Ser Thr Ser Phe Lys Pro Arg Ile Val Phe Glu Thr 
            20                  25                  30          

Pro Ser Pro Gly Leu Leu Thr Ile Trp Trp Arg Thr Arg Lys Ile Ser 
        35                  40                  45              

Arg Val Leu Gly Val Gln Arg Met Arg Glu Ile Ile Glu Tyr Arg Pro 
    50                  55                  60                  

Met Leu Thr Ser Leu Val Arg Ser Glu Leu Arg Ala Arg Tyr Lys Gly 
65                  70                  75                  80  

Ser Val Leu Gly Phe Leu Trp Thr Phe Val Asn Pro Leu Leu Gln Leu 
                85                  90                  95      

Ala Val Tyr Ser Leu Val Phe Lys Val Ile Leu Arg Ser Asn Ile Arg 
            100                 105                 110         

Asp Tyr Pro Val Phe Leu Phe Ile Gly Leu Leu Ala Trp Asn Met Phe 
        115                 120                 125             

Thr Gly Ala Leu Gln Ser Ser Cys Gly Val Ile Val Asn Lys Ala Ser 
    130                 135                 140                 

Leu Val Lys Lys Ile Tyr Phe Pro Arg Glu Ile Leu Pro Ala Ser Met 
145                 150                 155                 160 

Ala Gly Thr Ala Leu Val Asn Tyr Val Leu Ser Leu Ala Ile Leu Ile 
                165                 170                 175     

Pro Ile Leu Leu Ile Thr Gly Phe Trp Pro Thr Trp Ser Trp Leu Phe 
            180                 185                 190         

Ala Pro Val Ala Ile Val Ala Ile Phe Phe Met Ala Leu Gly Leu Ser 
        195                 200                 205             

Leu Ile Phe Ser Ala Ile Asn Val Tyr Met Arg Asp Thr Glu His Ile 
    210                 215                 220                 

Leu Asn Ile Val Leu Met Leu Trp Phe Tyr Gly Thr Pro Val Val Tyr 
225                 230                 235                 240 

Ser Ile Asn Ser Val Pro His Phe Leu Ser Ala Leu Phe Lys Val Asp 
                245                 250                 255     

Pro Ile Ala Ala Ala Ile Leu Val Leu Gln Glu Ile Phe Tyr Tyr Arg 
            260                 265                 270         

Glu Ile Pro His Trp Lys Met Leu Ile Tyr Cys Val Val Ser Gly Val 
        275                 280                 285             

Cys Ile Leu Trp Ile Gly Trp Ala Ile Phe Tyr Lys Leu Ser Arg Arg 
    290                 295                 300                 

Phe Ala Glu Glu Val 
305                 

<210>   230
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   230
Met Leu Lys Trp Pro Ser Thr Asp Leu Lys Gly Asn Pro Ser Ile Arg 
                5                   10                  15      

Met Ser Thr Arg Ser Thr Ser Phe Lys Pro Arg Ile Val Phe Glu Thr 
            20                  25                  30          

Pro Ser Pro Gly Leu Leu Thr Ile Trp Trp Arg Thr Arg Lys Val Ser 
        35                  40                  45              

Arg Val Leu Gly Val Gln Arg Met Arg Glu Ile Ile Glu Tyr Arg Pro 
    50                  55                  60                  

Met Leu Thr Ser Leu Val Arg Ser Glu Leu Arg Ala Arg Tyr Lys Gly 
65                  70                  75                  80  

Ser Val Leu Gly Phe Leu Trp Thr Phe Val Asn Pro Leu Leu Gln Leu 
                85                  90                  95      

Ala Val Tyr Ser Leu Val Phe Lys Val Ile Leu Arg Ser Asn Ile Arg 
            100                 105                 110         

Asp Tyr Pro Val Phe Leu Phe Ile Gly Leu Leu Ala Trp Asn Met Phe 
        115                 120                 125             

Thr Gly Ala Leu Gln Ser Ser Cys Gly Val Ile Val Asn Lys Ala Ser 
    130                 135                 140                 

Leu Val Lys Lys Ile Tyr Phe Pro Arg Glu Ile Leu Pro Ala Ser Met 
145                 150                 155                 160 

Ala Gly Thr Ala Leu Val Asn Tyr Val Leu Ser Leu Ala Ile Leu Ile 
                165                 170                 175     

Pro Ile Leu Leu Ile Thr Gly Phe Trp Pro Thr Trp Ser Trp Leu Phe 
            180                 185                 190         

Ala Pro Ile Ala Ile Val Ala Ile Phe Phe Met Ala Leu Gly Leu Ser 
        195                 200                 205             

Leu Ile Phe Ser Ala Ile Asn Val Tyr Met Arg Asp Thr Glu His Ile 
    210                 215                 220                 

Leu Asn Ile Val Leu Met Leu Trp Phe Tyr Gly Thr Pro Val Val Tyr 
225                 230                 235                 240 

Ser Ile Asn Ser Val Pro His Phe Leu Ser Ala Leu Phe Lys Val Asp 
                245                 250                 255     

Pro Ile Ala Ala Ala Ile Leu Val Leu Gln Glu Ile Phe Tyr Tyr Arg 
            260                 265                 270         

Glu Ile Pro His Trp Lys Met Leu Ile Tyr Cys Val Val Ser Gly Val 
        275                 280                 285             

Cys Ile Leu Trp Ile Gly Trp Ala Ile Phe Tyr Lys Leu Ser Arg Arg 
    290                 295                 300                 

Phe Ala Glu Glu Val 
305                 

<210>   231
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   231
Met Leu Lys Trp Pro Ser Thr Asp Leu Lys Gly Asn Pro Ser Ile Arg 
                5                   10                  15      

Met Ser Thr Arg Ser Thr Ser Phe Lys Pro Arg Ile Val Phe Glu Thr 
            20                  25                  30          

Pro Ser Pro Gly Leu Leu Thr Ile Trp Trp Arg Thr Arg Lys Val Ser 
        35                  40                  45              

Arg Val Leu Gly Val Asn Arg Met Arg Glu Ile Ile Glu Tyr Arg Pro 
    50                  55                  60                  

Met Leu Thr Ser Leu Val Arg Ser Glu Leu Arg Ala Arg Tyr Lys Gly 
65                  70                  75                  80  

Ser Val Leu Gly Phe Leu Trp Thr Phe Val Asn Pro Leu Leu Gln Leu 
                85                  90                  95      

Ala Val Tyr Ser Leu Val Phe Lys Val Ile Leu Arg Ser Asn Ile Arg 
            100                 105                 110         

Asp Tyr Pro Val Phe Leu Phe Ile Gly Leu Leu Ala Trp Asn Met Phe 
        115                 120                 125             

Thr Gly Ala Leu Gln Ser Ser Cys Gly Val Ile Val Asn Lys Ala Ser 
    130                 135                 140                 

Leu Val Lys Lys Ile Tyr Phe Pro Arg Glu Ile Leu Pro Ala Ser Met 
145                 150                 155                 160 

Ala Gly Thr Ala Leu Val Asn Tyr Val Leu Ser Leu Ala Ile Leu Ile 
                165                 170                 175     

Pro Ile Leu Leu Ile Thr Gly Phe Trp Pro Thr Trp Ser Trp Leu Phe 
            180                 185                 190         

Ala Pro Val Ala Ile Val Ala Ile Phe Phe Met Ala Leu Gly Leu Ser 
        195                 200                 205             

Leu Ile Phe Ser Ala Ile Asn Val Tyr Met Arg Asp Thr Glu His Ile 
    210                 215                 220                 

Leu Asn Ile Val Leu Met Leu Trp Phe Tyr Gly Thr Pro Val Val Tyr 
225                 230                 235                 240 

Ser Ile Asn Ser Val Pro His Phe Leu Ser Ala Leu Phe Lys Val Asp 
                245                 250                 255     

Pro Ile Ala Ala Ala Ile Leu Val Leu Gln Glu Ile Phe Tyr Tyr Arg 
            260                 265                 270         

Glu Ile Pro His Trp Lys Met Leu Ile Tyr Cys Val Val Ser Gly Val 
        275                 280                 285             

Cys Ile Leu Trp Ile Gly Trp Ala Ile Phe Tyr Lys Leu Ser Arg Arg 
    290                 295                 300                 

Phe Ala Glu Glu Val 
305                 

<210>   232
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   232
Met Leu Lys Trp Pro Ser Thr Asp Leu Lys Gly Asn Pro Ser Ile Arg 
                5                   10                  15      

Met Ser Thr Arg Ser Thr Ser Phe Lys Pro Arg Ile Val Phe Glu Thr 
            20                  25                  30          

Pro Ser Pro Gly Leu Leu Thr Ile Trp Trp Arg Thr Arg Lys Val Ser 
        35                  40                  45              

Arg Val Leu Gly Val Gln Arg Met Arg Glu Ile Ile Glu Tyr Arg Pro 
    50                  55                  60                  

Met Leu Thr Ser Leu Val Arg Ser Glu Leu Arg Ala Arg Tyr Lys Gly 
65                  70                  75                  80  

Ser Val Leu Gly Phe Leu Trp Thr Phe Val Asn Pro Leu Leu Gln Leu 
                85                  90                  95      

Ala Val Tyr Ser Leu Val Phe Lys Val Ile Leu Arg Ser Gln Ile Arg 
            100                 105                 110         

Asp Tyr Pro Val Phe Leu Phe Ile Gly Leu Leu Ala Trp Asn Met Phe 
        115                 120                 125             

Thr Gly Ala Leu Gln Ser Ser Cys Gly Val Ile Val Asn Lys Ala Ser 
    130                 135                 140                 

Leu Val Lys Lys Ile Tyr Phe Pro Arg Glu Ile Leu Pro Ala Ser Met 
145                 150                 155                 160 

Ala Gly Thr Ala Leu Val Asn Tyr Val Leu Ser Leu Ala Ile Leu Ile 
                165                 170                 175     

Pro Ile Leu Leu Ile Thr Gly Phe Trp Pro Thr Trp Ser Trp Leu Phe 
            180                 185                 190         

Ala Pro Val Ala Ile Val Ala Ile Phe Phe Met Ala Leu Gly Leu Ser 
        195                 200                 205             

Leu Ile Phe Ser Ala Ile Asn Val Tyr Met Arg Asp Thr Glu His Ile 
    210                 215                 220                 

Leu Asn Ile Val Leu Met Leu Trp Phe Tyr Gly Thr Pro Val Val Tyr 
225                 230                 235                 240 

Ser Ile Asn Ser Val Pro His Phe Leu Ser Ala Leu Phe Lys Val Asp 
                245                 250                 255     

Pro Ile Ala Ala Ala Ile Leu Val Leu Gln Glu Ile Phe Tyr Tyr Arg 
            260                 265                 270         

Glu Ile Pro His Trp Lys Met Leu Ile Tyr Cys Val Val Ser Gly Val 
        275                 280                 285             

Cys Ile Leu Trp Ile Gly Trp Ala Ile Phe Tyr Lys Leu Ser Arg Arg 
    290                 295                 300                 

Phe Ala Glu Glu Val 
305                 

<210>   233
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   233
Met Leu Lys Trp Pro Ser Thr Asp Leu Lys Gly Asn Pro Ser Ile Arg 
                5                   10                  15      

Met Ser Thr Arg Ser Thr Ser Phe Lys Pro Arg Ile Val Phe Glu Thr 
            20                  25                  30          

Pro Ser Pro Gly Leu Leu Thr Ile Trp Trp Arg Thr Arg Lys Val Ser 
        35                  40                  45              

Arg Val Leu Gly Val Gln Arg Met Arg Glu Ile Ile Glu Tyr Arg Pro 
    50                  55                  60                  

Met Leu Thr Ser Leu Val Arg Ser Glu Leu Arg Ala Arg Tyr Lys Gly 
65                  70                  75                  80  

Ser Val Leu Gly Phe Leu Trp Thr Phe Val Asn Pro Leu Leu Gln Leu 
                85                  90                  95      

Ala Val Tyr Ser Leu Val Phe Lys Val Ile Leu Arg Ser Asn Ile Arg 
            100                 105                 110         

Asp Tyr Pro Val Phe Leu Phe Ile Gly Leu Leu Ala Trp Asn Met Phe 
        115                 120                 125             

Thr Gly Ala Leu Gln Ser Ser Cys Gly Val Ile Val Asn Lys Ala Ser 
    130                 135                 140                 

Leu Val Lys Lys Ile Tyr Phe Pro Arg Glu Ile Leu Pro Ala Ser Met 
145                 150                 155                 160 

Ala Gly Thr Ala Leu Val Asn Tyr Val Leu Ser Leu Ala Ile Leu Ile 
                165                 170                 175     

Pro Ile Leu Leu Ile Thr Gly Phe Trp Pro Thr Trp Ser Trp Leu Phe 
            180                 185                 190         

Ala Pro Val Ala Ile Val Ala Ile Phe Phe Met Ala Leu Gly Leu Ser 
        195                 200                 205             

Leu Ile Phe Ser Ala Ile Asn Val Tyr Met Arg Asp Thr Glu His Ile 
    210                 215                 220                 

Leu Asn Ile Val Leu Met Leu Trp Phe Tyr Gly Thr Pro Val Val Tyr 
225                 230                 235                 240 

Ser Ile Asn Ser Val Pro His Phe Leu Ser Ala Leu Phe Lys Val Asp 
                245                 250                 255     

Pro Ile Ala Ala Ala Ile Leu Val Leu Gln Glu Ile Phe Tyr Tyr Arg 
            260                 265                 270         

Glu Ile Pro His Trp Lys Met Leu Ile Tyr Cys Val Val Ser Gly Val 
        275                 280                 285             

Cys Ile Leu Trp Ile Gly Trp Ala Ile Phe Tyr Lys Leu Ser Arg Arg 
    290                 295                 300                 

Phe Ala Glu Asp Val 
305                 

<210>   234
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   234
atgttaaaat ggccgtcgac cgatttgaaa gggaatcctt caattcggat gtctacgaga       60

agtacctcat tcaaaccgag gatagttttc gaaacgccgt cgccaggctt gttgacgatt      120

tggtggcgaa caagaaagat tagtcgcgtg ttgggcgtgc agcggatgcg cgagatcatt      180

gaataccgac ccatgcttac aagtcttgta cggtcggagc ttcgtgcgcg gtataagggg      240

tcagtcttag gttttctatg gactttcgtg aatccgctct tgcaactcgc ggtgtacagc      300

ctcgtcttca aagtgatctt gcgctctaat attagagact atcctgtatt tctttttatc      360

gggctgctgg catggaacat gttcacagga gcactgcaga gttcttgcgg tgtgattgtc      420

aataaggcat ccttagtcaa gaaaatctac tttcctagag aaattctacc tgcttctatg      480

gccggcacag cacttgtcaa ttatgttctg tcgcttgcta ttctcattcc tatcttgctg      540

attaccggtt tctggccgac ttggagttgg ttattcgcac ctgttgcaat cgtggctatt      600

tttttcatgg cattgggact ctctctaata ttctctgcta tcaatgtata catgagggat      660

accgaacaca tcttgaacat cgtgctgatg ctttggtttt acggaacacc tgtcgtatat      720

tcgatcaact ctgttcccca cttcctttca gctttgttta aagtagatcc gatagcggca      780

gcgatccttg tcttacagga gatcttttat taccgcgaaa tccctcattg gaaaatgttg      840

atatattgtg ttgttagcgg tgtctgcatt ctttggatcg gatgggctat tttctataag      900

ctcagtcgcc ggtttgcgga ggaggtgtga                                       930


<210>   235
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   235
atgttaaaat ggccgtcgac cgatttgaaa gggaatcctt caattcggat gtctacgaga       60

agtacctcat tcaaaccgag gatagttttc gaaacgccgt cgccaggctt gttgacgatt      120

tggtggcgaa caagaaaggt gagtcgcgtg ttgggcgtgc agcggatgcg cgagatcatt      180

gaataccgac ccatgcttac aagtcttgta cggtcggagc ttcgtgcgcg gtataagggg      240

tcagtcttag gttttctatg gactttcgtg aatccgctct tgcaactcgc ggtgtacagc      300

ctcgtcttca aagtgatctt gcgctctaat attagagact atcctgtatt tctttttatc      360

gggctgctgg catggaacat gttcacagga gcactgcaga gttcttgcgg tgtgattgtc      420

aataaggcat ccttagtcaa gaaaatctac tttcctagag aaattctacc tgcttctatg      480

gccggcacag cacttgtcaa ttatgttctg tcgcttgcta ttctcattcc tatcttgctg      540

attaccggtt tctggccgac ttggagttgg ttattcgcac ctattgcaat cgtggctatt      600

tttttcatgg cattgggact ctctctaata ttctctgcta tcaatgtata catgagggat      660

accgaacaca tcttgaacat cgtgctgatg ctttggtttt acggaacacc tgtcgtatat      720

tcgatcaact ctgttcccca cttcctttca gctttgttta aagtagatcc gatagcggca      780

gcgatccttg tcttacagga gatcttttat taccgcgaaa tccctcattg gaaaatgttg      840

atatattgtg ttgttagcgg tgtctgcatt ctttggatcg gatgggctat tttctataag      900

ctcagtcgcc ggtttgcgga ggaggtgtga                                       930


<210>   236
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   236
atgttaaaat ggccgtcgac cgatttgaaa gggaatcctt caattcggat gtctacgaga       60

agtacctcat tcaaaccgag gatagttttc gaaacgccgt cgccaggctt gttgacgatt      120

tggtggcgaa caagaaaggt gagtcgcgtg ttgggcgtga atcggatgcg cgagatcatt      180

gaataccgac ccatgcttac aagtcttgta cggtcggagc ttcgtgcgcg gtataagggg      240

tcagtcttag gttttctatg gactttcgtg aatccgctct tgcaactcgc ggtgtacagc      300

ctcgtcttca aagtgatctt gcgctctaat attagagact atcctgtatt tctttttatc      360

gggctgctgg catggaacat gttcacagga gcactgcaga gttcttgcgg tgtgattgtc      420

aataaggcat ccttagtcaa gaaaatctac tttcctagag aaattctacc tgcttctatg      480

gccggcacag cacttgtcaa ttatgttctg tcgcttgcta ttctcattcc tatcttgctg      540

attaccggtt tctggccgac ttggagttgg ttattcgcac ctgttgcaat cgtggctatt      600

tttttcatgg cattgggact ctctctaata ttctctgcta tcaatgtata catgagggat      660

accgaacaca tcttgaacat cgtgctgatg ctttggtttt acggaacacc tgtcgtatat      720

tcgatcaact ctgttcccca cttcctttca gctttgttta aagtagatcc gatagcggca      780

gcgatccttg tcttacagga gatcttttat taccgcgaaa tccctcattg gaaaatgttg      840

atatattgtg ttgttagcgg tgtctgcatt ctttggatcg gatgggctat tttctataag      900

ctcagtcgcc ggtttgcgga ggaggtgtga                                       930


<210>   237
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   237
atgttaaaat ggccgtcgac cgatttgaaa gggaatcctt caattcggat gtctacgaga       60

agtacctcat tcaaaccgag gatagttttc gaaacgccgt cgccaggctt gttgacgatt      120

tggtggcgaa caagaaaggt gagtcgcgtg ttgggcgtgc agcggatgcg cgagatcatt      180

gaataccgac ccatgcttac aagtcttgta cggtcggagc ttcgtgcgcg gtataagggg      240

tcagtcttag gttttctatg gactttcgtg aatccgctct tgcaactcgc ggtgtacagc      300

ctcgtcttca aagtgatctt gcgctctcaa attagagact atcctgtatt tctttttatc      360

gggctgctgg catggaacat gttcacagga gcactgcaga gttcttgcgg tgtgattgtc      420

aataaggcat ccttagtcaa gaaaatctac tttcctagag aaattctacc tgcttctatg      480

gccggcacag cacttgtcaa ttatgttctg tcgcttgcta ttctcattcc tatcttgctg      540

attaccggtt tctggccgac ttggagttgg ttattcgcac ctgttgcaat cgtggctatt      600

tttttcatgg cattgggact ctctctaata ttctctgcta tcaatgtata catgagggat      660

accgaacaca tcttgaacat cgtgctgatg ctttggtttt acggaacacc tgtcgtatat      720

tcgatcaact ctgttcccca cttcctttca gctttgttta aagtagatcc gatagcggca      780

gcgatccttg tcttacagga gatcttttat taccgcgaaa tccctcattg gaaaatgttg      840

atatattgtg ttgttagcgg tgtctgcatt ctttggatcg gatgggctat tttctataag      900

ctcagtcgcc ggtttgcgga ggaggtgtga                                       930


<210>   238
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   238
atgttaaaat ggccgtcgac cgatttgaaa gggaatcctt caattcggat gtctacgaga       60

agtacctcat tcaaaccgag gatagttttc gaaacgccgt cgccaggctt gttgacgatt      120

tggtggcgaa caagaaaggt gagtcgcgtg ttgggcgtgc agcggatgcg cgagatcatt      180

gaataccgac ccatgcttac aagtcttgta cggtcggagc ttcgtgcgcg gtataagggg      240

tcagtcttag gttttctatg gactttcgtg aatccgctct tgcaactcgc ggtgtacagc      300

ctcgtcttca aagtgatctt gcgctctaat attagagact atcctgtatt tctttttatc      360

gggctgctgg catggaacat gttcacagga gcactgcaga gttcttgcgg tgtgattgtc      420

aataaggcat ccttagtcaa gaaaatctac tttcctagag aaattctacc tgcttctatg      480

gccggcacag cacttgtcaa ttatgttctg tcgcttgcta ttctcattcc tatcttgctg      540

attaccggtt tctggccgac ttggagttgg ttattcgcac ctgttgcaat cgtggctatt      600

tttttcatgg cattgggact ctctctaata ttctctgcta tcaatgtata catgagggat      660

accgaacaca tcttgaacat cgtgctgatg ctttggtttt acggaacacc tgtcgtatat      720

tcgatcaact ctgttcccca cttcctttca gctttgttta aagtagatcc gatagcggca      780

gcgatccttg tcttacagga gatcttttat taccgcgaaa tccctcattg gaaaatgttg      840

atatattgtg ttgttagcgg tgtctgcatt ctttggatcg gatgggctat tttctataag      900

ctcagtcgcc ggtttgcgga ggatgtgtga                                       930


<210>   239
<211>   392
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   239
Met Ala Thr Ser Ala Ile Glu Val Cys Asn Val Thr Lys Ser Phe Arg 
                5                   10                  15      

Val His Ile Gly Lys Asn Gln Thr Leu Lys Glu Lys Leu Phe Tyr Met 
            20                  25                  30          

Gly Lys Ser Lys Tyr Arg Asp Phe Ile Ala Leu Lys Asp Val Ser Val 
        35                  40                  45              

Arg Ile Pro Lys Gly Ala Thr Val Gly Leu Ile Gly Met Asn Gly Ser 
    50                  55                  60                  

Gly Lys Ser Thr Leu Leu Lys Leu Ile Ser Arg Ile Ile Tyr Pro Asp 
65                  70                  75                  80  

Lys Gly Glu Ile Arg Val His Gly Arg Val Ser Ser Leu Leu Glu Leu 
                85                  90                  95      

Gly Ala Gly Phe His Pro Glu Phe Thr Gly Leu Glu Asn Ile Tyr Met 
            100                 105                 110         

Asn Ala Ala Ile Leu Gly Leu Ser Lys Arg Glu Val Asp Lys Lys Leu 
        115                 120                 125             

Ala Glu Ile Val Glu Phe Ser Glu Leu Gly Asp Phe Leu Asn Glu Pro 
    130                 135                 140                 

Val Arg Ser Tyr Ser Ser Gly Met Tyr Met Arg Leu Ala Phe Ser Val 
145                 150                 155                 160 

Ala Val Ala Val Asp Pro Glu Ile Leu Leu Val Asp Glu Val Leu Ala 
                165                 170                 175     

Val Gly Asp Ala Ala Phe Gln Glu Lys Cys Leu Glu Arg Val Arg Arg 
            180                 185                 190         

Leu Arg Arg Glu Gly Lys Thr Ile Val Ile Val Thr His Asp Thr Gly 
        195                 200                 205             

Val Val Glu Gln Leu Cys Asp His Val Val Trp Leu His Asn Ser Arg 
    210                 215                 220                 

Val Arg Met Glu Gly Arg Pro Glu Glu Cys Ile Pro His Tyr Leu Asp 
225                 230                 235                 240 

Glu Ile Leu Gly Glu Arg Arg Gly Thr Gly Met Ser Phe Asp Arg Val 
                245                 250                 255     

Glu Gln Pro Pro Leu Gln Pro Gly Asp Glu Leu Lys Asp Leu Gly Leu 
            260                 265                 270         

Gly Leu Arg Val Gly Ile Arg Glu Asn Ala Glu Val Leu Pro Asn Asp 
        275                 280                 285             

Gly Gly Ile Arg Val Val Tyr Glu Ala Ser Ala Ala His Glu Val Cys 
    290                 295                 300                 

Cys Glu Ala Ser Val Val Ile Arg Arg Leu Gly Asp Pro Gln Glu Leu 
305                 310                 315                 320 

Arg Pro Arg Cys Asn Glu Lys Ile Ala Leu Pro Lys Gly His Ser Val 
                325                 330                 335     

Leu Glu Leu His Ala Thr Leu Asp Arg Ala Leu Tyr Pro Gly Glu Tyr 
            340                 345                 350         

Met Ile Glu Leu Val Leu Gln Val Asn Asp His Ile Leu Arg Ala Pro 
        355                 360                 365             

Ala Thr Arg Leu Trp Ile Pro His Ser Ser Gln Glu Glu Ser Leu Gln 
    370                 375                 380                 

Leu Gln Val Ser Val Gln Thr Ala 
385                 390         

<210>   240
<211>   1179
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   240
atggccacaa gtgctattga ggtatgcaat gtcaccaagt cgtttcgtgt ccatattggg       60

aaaaatcaga cgttaaaaga aaaattgttc tacatgggga agagcaagta tcgagatttt      120

atcgcgctca aagacgtgtc cgtgcgaatt cccaaaggag ccaccgttgg actcattggc      180

atgaacggtt caggtaagag tacgctctta aaactgatat ctcgcattat atatccagat      240

aaaggggaaa ttcgtgttca cggacgggtt tctagcttac tggagcttgg tgcaggcttt      300

catccggagt ttacggggtt agagaacatc tatatgaatg cagccatact gggattgtca      360

aagcgcgagg tggacaagaa gctggccgag atcgtcgagt tctctgagtt aggtgatttt      420

ctgaatgagc ccgttcgaag ctactcgtcg ggtatgtaca tgaggctcgc cttctctgtc      480

gcggtcgcgg tggatccgga aattttgctc gtggacgaag tattagcggt gggagacgct      540

gcttttcagg agaaatgcct tgaacgtgtc cgcaggttga gaagagaggg aaagacgatc      600

gtcattgtca cacacgacac gggagtcgtg gaacaattgt gcgatcacgt ggtctggtta      660

cataactcgc gcgttcgaat ggaagggcgg ccggaggaat gtatcccaca ttatctagac      720

gaaatcctag gagagcgtag gggaacgggc atgtcgtttg accgagtgga acaaccacct      780

ttgcaacccg gcgatgaact gaaggacttg ggtttgggat tacgtgtcgg cattcgagaa      840

aatgccgaag ttcttccgaa cgacggcggg attcgggtcg tctacgaggc gtcggccgcg      900

catgaggtct gctgtgaggc gagcgtcgtg attcggcgtc ttggcgaccc acaagaactt      960

cggcctaggt gcaacgaaaa gatcgcattg cctaaggggc attcagttct tgagttgcat     1020

gctactcttg atcgagcgtt gtaccctggg gagtatatga ttgaactcgt gttacaggta     1080

aatgatcaca tattgcgtgc acctgcaact cgtttgtgga tccctcattc ttcgcaagag     1140

gaaagtctgc aactgcaagt ctcggttcaa acggcctaa                            1179


<210>   241
<211>   350
<212>   PRT
<213>   Clostridium sp. L2-50

<400>   241
Ala Ile Glu Val Gln His Ile Ser Lys Ser Phe Lys Ile Ser Tyr Asp 
                5                   10                  15      

Lys Ser Lys Thr Leu Lys Asp Lys Ile Ile Phe Ala Lys Lys Asp Lys 
            20                  25                  30          

Tyr Glu Ile His Gln Val Leu Asp Asp Val Ser Phe Thr Ile Glu Lys 
        35                  40                  45              

Gly Glu Ala Val Gly Leu Ile Gly His Asn Gly Cys Gly Lys Ser Thr 
    50                  55                  60                  

Thr Leu Lys Leu Leu Thr Arg Ile Ile Tyr Pro Asp Ser Gly Glu Ile 
65                  70                  75                  80  

Ser Ile Asp Gly Arg Val Ser Ser Leu Leu Glu Leu Gly Ala Gly Phe 
                85                  90                  95      

His Pro Asp Met Thr Gly Arg Glu Asn Ile Tyr Thr Asn Ala Ser Ile 
            100                 105                 110         

Phe Gly Leu Thr Lys Lys Glu Ile Asp Glu Arg Leu Asp Glu Ile Ile 
        115                 120                 125             

Glu Phe Ser Glu Leu Glu Glu Phe Ile Asp Asn Pro Val Arg Thr Tyr 
    130                 135                 140                 

Ser Ser Gly Met Tyr Met Arg Leu Ala Phe Ser Val Ala Ile Asn Val 
145                 150                 155                 160 

Asn Ala Asp Ile Leu Leu Ile Asp Glu Ile Leu Ala Val Gly Asp Ser 
                165                 170                 175     

Asn Phe Gln Leu Lys Cys Ala Asn Lys Met Gln Glu Leu Lys Lys Glu 
            180                 185                 190         

Gly Ile Thr Ile Val Ile Val Ser His Ser Met Gly Gln Ile Glu Glu 
        195                 200                 205             

Leu Cys Asp Arg Cys Ile Trp Leu Asp Lys Gly Lys Ile Val Ser Asp 
    210                 215                 220                 

Gly Thr Pro Gln Tyr Val His Lys Leu Tyr Met Glu Phe Met Gly Gln 
225                 230                 235                 240 

Ala Arg Ala Glu Arg Ser Glu Lys Glu Arg Gln Leu Met Glu Glu Ala 
                245                 250                 255     

Lys Asn Leu Asp Leu Ser Ile Thr Lys Val Glu Cys Lys Asn Asn Ala 
            260                 265                 270         

Gly Glu Pro Arg Val Ala Phe Ser Ile Asp Asp Asp Ile Asn Ile Thr 
        275                 280                 285             

Leu Tyr Tyr Lys Ile Lys Ser Pro Arg Lys Val Ala Val Gln Phe Thr 
    290                 295                 300                 

Val Phe Arg Ser Asp Tyr Met Met Cys Tyr Glu Arg Arg Thr Asp Ala 
305                 310                 315                 320 

Glu Lys Gly Thr Val Leu Leu Glu Gly Glu Gly Lys Ile Gln Leu Lys 
                325                 330                 335     

Leu Arg Lys Val Gln Leu Leu Leu Gly His Tyr Met Ile Asp 
            340                 345                 350 

<210>   242
<211>   262
<212>   PRT
<213>   Clostridium bolteae ATCC BAA-613

<400>   242
Ala Glu Asn Ala Ile Glu Val His Asp Ile Lys Lys Ser Phe Arg Val 
                5                   10                  15      

Tyr Leu Asp Lys Gly Arg Thr Leu Lys Glu Leu Val Leu Phe Ser Lys 
            20                  25                  30          

Arg Arg Lys Tyr Glu Glu Arg Gln Val Leu Gln Gly Ile Ser Phe Glu 
        35                  40                  45              

Val Lys Lys Gly Glu Ala Leu Gly Leu Ile Gly His Asn Gly Cys Gly 
    50                  55                  60                  

Lys Ser Thr Thr Leu Lys Leu Leu Thr Arg Ile Met Tyr Pro Asp Ser 
65                  70                  75                  80  

Gly Thr Ile Glu Met Arg Gly Arg Val Ser Ser Leu Ile Glu Leu Gly 
                85                  90                  95      

Ala Gly Phe His Pro Asp Met Ser Gly Arg Gln Asn Ile Tyr Thr Asn 
            100                 105                 110         

Ala Ser Ile Phe Gly Leu Thr Arg Lys Glu Ile Asp Ala Arg Val Asp 
        115                 120                 125             

Asn Ile Ile Glu Phe Ser Glu Leu Glu Ala Phe Ile Asp Asn Pro Val 
    130                 135                 140                 

Arg Thr Tyr Ser Ser Gly Met Tyr Met Arg Leu Ala Phe Ala Val Ala 
145                 150                 155                 160 

Ile Asn Val Asp Ala Asp Ile Leu Leu Val Asp Glu Ile Leu Ala Val 
                165                 170                 175     

Gly Asp Ala Asn Phe Gln Ala Lys Cys Phe Asn Lys Leu Arg Glu Ile 
            180                 185                 190         

Lys Ala Asn Gly Thr Thr Ile Val Ile Val Ser His Ser Leu Gly Gln 
        195                 200                 205             

Ile Glu Glu Ile Cys Glu Arg Ser Ile Trp Ile His Glu Gly Lys Ile 
    210                 215                 220                 

Gln Lys Glu Gly Asn Pro Arg Glu Val His Pro Ala Tyr Leu Glu Tyr 
225                 230                 235                 240 

Met Gly Gln Lys Arg Pro Glu Ala Ala Ser Glu Lys Val Lys Ser Glu 
                245                 250                 255     

Gly Glu Arg Pro Gly Asp 
            260         

<210>   243
<211>   275
<212>   PRT
<213>   Clostridium bolteae ATCC BAA-613

<400>   243
Ala Ile Asp Val Ala Glu Val Thr Lys Val Tyr Arg Leu Tyr Glu Lys 
                5                   10                  15      

Pro Ile Asp Arg Leu Lys Glu Ser Met Ser Ile Ser His Lys Asn Tyr 
            20                  25                  30          

His Arg Asp Phe Tyr Ala Leu Asn Gln Leu Ser Phe Arg Val Arg Lys 
        35                  40                  45              

Gly Glu Thr Val Gly Ile Ile Gly Thr Asn Gly Ser Gly Lys Ser Thr 
    50                  55                  60                  

Ile Leu Lys Ile Ile Thr Gly Val Leu Thr Pro Thr Thr Gly Glu Val 
65                  70                  75                  80  

Lys Val Asp Gly Lys Ile Ser Ala Leu Leu Glu Leu Gly Ala Gly Phe 
                85                  90                  95      

Asn Met Asp Tyr Thr Gly Ile Glu Asn Ile Tyr Met Asn Gly Thr Met 
            100                 105                 110         

Met Gly Tyr Thr Lys Lys Glu Met Asp Ala Lys Leu Gln Asp Ile Leu 
        115                 120                 125             

Glu Phe Ala Glu Ile Gly Asp Phe Val Tyr Gln Pro Val Lys Thr Tyr 
    130                 135                 140                 

Ser Ser Gly Met Phe Val Arg Leu Ala Phe Ala Leu Ala Ile Asn Val 
145                 150                 155                 160 

Asp Pro Glu Ile Leu Ile Val Asp Glu Ala Leu Ser Val Gly Asp Val 
                165                 170                 175     

Phe Phe Gln Ser Lys Cys Tyr Arg Arg Met Glu Glu Ile Arg Gln Lys 
            180                 185                 190         

Gly Thr Thr Ile Leu Met Val Thr His Asp Met Gly Ser Ile Ile Lys 
        195                 200                 205             

Tyr Cys Asp Arg Val Val Leu Leu Asn Lys Gly Glu Phe Ile Ala Glu 
    210                 215                 220                 

Gly Pro Ala Gly Arg Val Val Asp Met Tyr Lys Lys Ile Leu Ala Gly 
225                 230                 235                 240 

Gln Leu Asp Ala Leu Lys Ala Glu Leu Glu Arg Glu Arg Gln Gln Lys 
                245                 250                 255     

Glu Ser Leu Thr Gly Glu Ile Gly Gln Glu Asp Ala Gly Ser Gly Val 
            260                 265                 270         

Leu Thr Gly 
        275 

<210>   244
<211>   242
<212>   PRT
<213>   Vibrio cholerae MZO-2

<400>   244
Ala Cys Ile Glu Val Lys Asp Ile Ser Lys Cys Phe Gln Ile Tyr Asn 
                5                   10                  15      

Lys Pro Ser Asp Arg Leu Lys Gln Phe Ile Val Pro Lys Leu Pro Leu 
            20                  25                  30          

Ile Gly Lys Lys Tyr Asn Cys Phe Tyr Lys Glu Phe Trp Ala Leu Lys 
        35                  40                  45              

Asn Ile Ser Val Glu Ile Lys Glu Gly Glu Val Val Gly Ile Ile Gly 
    50                  55                  60                  

Gln Asn Gly Ala Gly Lys Ser Thr Leu Leu Gln Leu Ile Cys Gly Thr 
65                  70                  75                  80  

Leu His Gln Thr Thr Gly Glu Val Ile Lys Arg Gly Arg Ile Ser Ala 
                85                  90                  95      

Leu Leu Glu Leu Gly Ser Gly Phe Asn Pro Glu Tyr Ser Gly Arg Glu 
            100                 105                 110         

Asn Val Tyr Leu Asn Ala Ser Ile Leu Gly Leu Ser Lys Lys Glu Ile 
        115                 120                 125             

Asp Glu Lys Phe Glu Asp Ile Glu Lys Phe Ala Asp Ile Gly Ser Phe 
    130                 135                 140                 

Ile Asp Gln Pro Val Lys Ser Tyr Ser Ser Gly Met Tyr Val Arg Leu 
145                 150                 155                 160 

Ala Phe Ser Val Ala Ile His Val Glu Pro Ser Ile Leu Ile Val Asp 
                165                 170                 175     

Glu Ala Leu Ala Val Gly Asp Ile Arg Phe Gln Thr Lys Cys Leu Arg 
            180                 185                 190         

Ala Ile Asp Glu Leu Lys Lys Gly Gly Thr Ser Ile Ile Phe Val Thr 
        195                 200                 205             

His Ser Ser Gly Gln Ile Glu Ala Leu Cys Asp Arg Val Leu Trp Leu 
    210                 215                 220                 

His Lys Gly Glu Leu Leu Val Ser Gly Glu Pro Ser Lys Val Met Arg 
225                 230                 235                 240 

His Tyr 
        

<210>   245
<211>   294
<212>   PRT
<213>   Actinomyces odontolyticus ATCC 17982

<400>   245
Thr Asn Ala Ile Ser Val Glu Gly Val Ser Lys Arg Phe Arg Ile Tyr 
                5                   10                  15      

Lys Asn Arg Asn Gln Ser Leu Lys Gly Ala Phe Leu Gln Arg Ser Arg 
            20                  25                  30          

Ala Gln Phe Glu Glu Phe Trp Ala Leu Asp Asp Val Ser Phe Glu Ile 
        35                  40                  45              

Pro Gln Gly Lys Thr Phe Gly Leu Leu Gly His Asn Gly Ser Gly Lys 
    50                  55                  60                  

Ser Thr Leu Leu Lys Cys Ile Ala Lys Ile Leu Thr Pro Asp Arg Gly 
65                  70                  75                  80  

Thr Ile Ser Ser Thr Gly Arg Met Ala Ala Met Leu Glu Val Gly Ser 
                85                  90                  95      

Gly Phe His Pro Glu Leu Ser Gly Arg Glu Asn Ile Tyr Leu Asn Gly 
            100                 105                 110         

Ala Ile Leu Gly Met Ser Lys Lys Glu Ile Asp Ser Lys Leu Asp Ala 
        115                 120                 125             

Ile Ile Asp Phe Ser Gly Val Glu Arg Phe Ile Asp Gln Pro Val Lys 
    130                 135                 140                 

Asn Tyr Ser Ser Gly Met Tyr Val Arg Leu Gly Phe Ser Val Ser Ile 
145                 150                 155                 160 

His Val Glu Pro Asp Ile Leu Leu Val Asp Glu Val Leu Ala Val Gly 
                165                 170                 175     

Asp Met Glu Phe Gln Asn Lys Cys Met Asp Lys Phe Ala Gln Leu Lys 
            180                 185                 190         

Asp Gln Gly Arg Thr Val Val Val Val Ser His Gly Leu Glu Gln Met 
        195                 200                 205             

Arg Thr Phe Cys Asp Gln Ala Ala Trp Leu Asp His Gly Thr Leu Val 
    210                 215                 220                 

Asp Val Gly Ala Ala Ala Glu Val Ile Asp Thr Tyr Ser Asp Val Ala 
225                 230                 235                 240 

His His Ala Val Glu Val Glu Gly Gly Gly Thr Arg Phe Gly Ser Gly 
                245                 250                 255     

Glu Ala Met Ile Glu Arg Ile Glu Leu Leu Ser Ala Ser Gly Gln Pro 
            260                 265                 270         

Thr Ser Leu Val Tyr Pro Gly Asp Pro Val Arg Leu Arg Leu His Tyr 
        275                 280                 285             

Arg Ala Asn Glu Arg Ile 
    290                 

<210>   246
<211>   392
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   246
Met Ala Thr Ser Ala Ile Glu Val Cys Asn Val Thr Lys Ser Phe Arg 
                5                   10                  15      

Val His Ile Gly Lys Asn Gln Thr Leu Lys Glu Lys Leu Phe Tyr Met 
            20                  25                  30          

Gly Lys Ser Lys Tyr Arg Asp Phe Ile Ala Leu Lys Asp Val Ser Val 
        35                  40                  45              

Arg Ile Pro Lys Gly Ala Thr Val Gly Leu Ile Gly Met Asn Gly Ser 
    50                  55                  60                  

Gly Lys Ser Thr Leu Leu Lys Leu Ile Ser Arg Ile Ile Tyr Pro Asp 
65                  70                  75                  80  

Lys Gly Glu Ile Arg Val His Gly Arg Val Ser Ser Leu Leu Glu Leu 
                85                  90                  95      

Gly Ala Gly Phe His Pro Glu Phe Thr Gly Leu Glu Asn Ile Tyr Met 
            100                 105                 110         

Asn Ala Ala Ile Leu Gly Leu Ser Lys Arg Glu Val Asp Lys Lys Leu 
        115                 120                 125             

Ala Glu Ile Val Glu Phe Ser Glu Leu Gly Asp Phe Leu Asn Glu Pro 
    130                 135                 140                 

Val Arg Ser Tyr Ser Ser Gly Met Tyr Met Arg Leu Ala Phe Ser Val 
145                 150                 155                 160 

Ala Val Ala Val Asp Pro Glu Ile Leu Leu Val Asp Glu Val Leu Ala 
                165                 170                 175     

Val Gly Asp Ala Ala Phe Gln Glu Lys Cys Ile Glu Arg Val Arg Arg 
            180                 185                 190         

Leu Arg Arg Glu Gly Lys Thr Ile Val Ile Val Thr His Asp Thr Gly 
        195                 200                 205             

Val Val Glu Gln Leu Cys Asp His Val Val Trp Leu His Asn Ser Arg 
    210                 215                 220                 

Val Arg Met Glu Gly Arg Pro Glu Glu Cys Ile Pro His Tyr Leu Asp 
225                 230                 235                 240 

Glu Ile Leu Gly Glu Arg Arg Gly Thr Gly Met Ser Phe Asp Arg Val 
                245                 250                 255     

Glu Gln Pro Pro Leu Gln Pro Gly Asp Glu Leu Lys Asp Leu Gly Leu 
            260                 265                 270         

Gly Leu Arg Val Gly Ile Arg Glu Asn Ala Glu Val Leu Pro Asn Asp 
        275                 280                 285             

Gly Gly Ile Arg Val Val Tyr Glu Ala Ser Ala Ala His Glu Val Cys 
    290                 295                 300                 

Cys Glu Ala Ser Val Val Ile Arg Arg Leu Gly Asp Pro Gln Glu Leu 
305                 310                 315                 320 

Arg Pro Arg Cys Asn Glu Lys Ile Ala Leu Pro Lys Gly His Ser Val 
                325                 330                 335     

Leu Glu Leu His Ala Thr Leu Asp Arg Ala Leu Tyr Pro Gly Glu Tyr 
            340                 345                 350         

Met Ile Glu Leu Val Leu Gln Val Asn Asp His Ile Leu Arg Ala Pro 
        355                 360                 365             

Ala Thr Arg Leu Trp Ile Pro His Ser Ser Gln Glu Glu Ser Leu Gln 
    370                 375                 380                 

Leu Gln Val Ser Val Gln Thr Ala 
385                 390         

<210>   247
<211>   392
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   247
Met Ala Thr Ser Ala Ile Glu Val Cys Asn Val Thr Lys Ser Phe Arg 
                5                   10                  15      

Val His Ile Gly Lys Asn Gln Thr Leu Lys Glu Lys Leu Phe Tyr Met 
            20                  25                  30          

Gly Lys Ser Lys Tyr Arg Asp Phe Ile Ala Leu Lys Asp Val Ser Val 
        35                  40                  45              

Arg Ile Pro Lys Gly Ala Thr Val Gly Leu Ile Gly Met Asn Gly Ser 
    50                  55                  60                  

Gly Lys Ser Thr Leu Leu Lys Leu Ile Ser Arg Ile Ile Tyr Pro Asp 
65                  70                  75                  80  

Lys Gly Glu Ile Arg Val His Gly Arg Val Ser Ser Leu Leu Glu Leu 
                85                  90                  95      

Gly Ala Gly Phe His Pro Glu Phe Thr Gly Leu Glu Asn Ile Tyr Met 
            100                 105                 110         

Asn Ala Ala Ile Leu Gly Leu Ser Lys Arg Glu Val Asp Lys Lys Leu 
        115                 120                 125             

Ala Glu Ile Val Glu Phe Ser Glu Leu Gly Asp Phe Leu Asn Glu Pro 
    130                 135                 140                 

Val Arg Ser Tyr Ser Ser Gly Met Tyr Met Arg Leu Ala Phe Ser Val 
145                 150                 155                 160 

Ala Val Ala Val Asp Pro Glu Ile Leu Leu Val Asp Glu Val Leu Ala 
                165                 170                 175     

Val Gly Asp Ala Ala Phe Gln Glu Lys Cys Leu Glu Arg Val Arg Arg 
            180                 185                 190         

Leu Arg Arg Glu Gly Lys Thr Ile Val Ile Val Thr His Asp Thr Gly 
        195                 200                 205             

Val Val Glu Gln Leu Cys Asp His Val Val Trp Leu His Asn Ser Arg 
    210                 215                 220                 

Val Arg Met Glu Gly Arg Pro Glu Glu Cys Ile Pro His Tyr Leu Asp 
225                 230                 235                 240 

Glu Ile Leu Gly Glu Arg Arg Gly Thr Gly Met Ser Phe Asp Arg Val 
                245                 250                 255     

Glu Gln Pro Pro Leu Gln Pro Gly Glu Glu Leu Lys Asp Leu Gly Leu 
            260                 265                 270         

Gly Leu Arg Val Gly Ile Arg Glu Asn Ala Glu Val Leu Pro Asn Asp 
        275                 280                 285             

Gly Gly Ile Arg Val Val Tyr Glu Ala Ser Ala Ala His Glu Val Cys 
    290                 295                 300                 

Cys Glu Ala Ser Val Val Ile Arg Arg Leu Gly Asp Pro Gln Glu Leu 
305                 310                 315                 320 

Arg Pro Arg Cys Asn Glu Lys Ile Ala Leu Pro Lys Gly His Ser Val 
                325                 330                 335     

Leu Glu Leu His Ala Thr Leu Asp Arg Ala Leu Tyr Pro Gly Glu Tyr 
            340                 345                 350         

Met Ile Glu Leu Val Leu Gln Val Asn Asp His Ile Leu Arg Ala Pro 
        355                 360                 365             

Ala Thr Arg Leu Trp Ile Pro His Ser Ser Gln Glu Glu Ser Leu Gln 
    370                 375                 380                 

Leu Gln Val Ser Val Gln Thr Ala 
385                 390         

<210>   248
<211>   392
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   248
Met Ala Thr Ser Ala Ile Glu Val Cys Asn Val Thr Lys Ser Phe Arg 
                5                   10                  15      

Val His Ile Gly Lys Asn Gln Thr Leu Lys Glu Lys Leu Phe Tyr Met 
            20                  25                  30          

Gly Lys Ser Lys Tyr Arg Asp Phe Ile Ala Leu Lys Asp Val Ser Val 
        35                  40                  45              

Arg Ile Pro Lys Gly Ala Thr Val Gly Leu Ile Gly Met Asn Gly Ser 
    50                  55                  60                  

Gly Lys Ser Thr Leu Leu Lys Leu Ile Ser Arg Ile Ile Tyr Pro Asp 
65                  70                  75                  80  

Lys Gly Glu Ile Arg Val His Gly Arg Val Ser Ser Leu Leu Glu Leu 
                85                  90                  95      

Gly Ala Gly Phe His Pro Glu Phe Thr Gly Leu Glu Asn Ile Tyr Met 
            100                 105                 110         

Asn Ala Ala Ile Leu Gly Leu Ser Lys Arg Glu Val Asp Lys Lys Leu 
        115                 120                 125             

Ala Glu Ile Val Glu Phe Ser Glu Leu Gly Asp Phe Leu Asn Glu Pro 
    130                 135                 140                 

Val Arg Ser Tyr Ser Ser Gly Met Tyr Met Arg Leu Ala Phe Ser Val 
145                 150                 155                 160 

Ala Val Ala Val Asp Pro Glu Ile Leu Leu Val Asp Glu Val Leu Ala 
                165                 170                 175     

Val Gly Asp Ala Ala Phe Gln Glu Lys Cys Leu Glu Arg Val Arg Arg 
            180                 185                 190         

Leu Arg Arg Glu Gly Lys Thr Ile Val Ile Val Thr His Asp Thr Gly 
        195                 200                 205             

Val Val Glu Gln Leu Cys Asp His Val Val Trp Leu His Asn Ser Arg 
    210                 215                 220                 

Val Arg Met Glu Gly Arg Pro Glu Glu Cys Ile Pro His Tyr Leu Asp 
225                 230                 235                 240 

Glu Ile Leu Gly Glu Arg Arg Gly Thr Gly Met Ser Phe Asp Arg Val 
                245                 250                 255     

Glu Gln Pro Pro Leu Gln Pro Gly Asp Glu Leu Lys Asp Leu Gly Leu 
            260                 265                 270         

Gly Leu Arg Val Gly Ile Arg Glu Gln Ala Glu Val Leu Pro Asn Asp 
        275                 280                 285             

Gly Gly Ile Arg Val Val Tyr Glu Ala Ser Ala Ala His Glu Val Cys 
    290                 295                 300                 

Cys Glu Ala Ser Val Val Ile Arg Arg Leu Gly Asp Pro Gln Glu Leu 
305                 310                 315                 320 

Arg Pro Arg Cys Asn Glu Lys Ile Ala Leu Pro Lys Gly His Ser Val 
                325                 330                 335     

Leu Glu Leu His Ala Thr Leu Asp Arg Ala Leu Tyr Pro Gly Glu Tyr 
            340                 345                 350         

Met Ile Glu Leu Val Leu Gln Val Asn Asp His Ile Leu Arg Ala Pro 
        355                 360                 365             

Ala Thr Arg Leu Trp Ile Pro His Ser Ser Gln Glu Glu Ser Leu Gln 
    370                 375                 380                 

Leu Gln Val Ser Val Gln Thr Ala 
385                 390         

<210>   249
<211>   392
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   249
Met Ala Thr Ser Ala Ile Glu Val Cys Asn Val Thr Lys Ser Phe Arg 
                5                   10                  15      

Val His Ile Gly Lys Asn Gln Thr Leu Lys Glu Lys Leu Phe Tyr Met 
            20                  25                  30          

Gly Lys Ser Lys Tyr Arg Asp Phe Ile Ala Leu Lys Asp Val Ser Val 
        35                  40                  45              

Arg Ile Pro Lys Gly Ala Thr Val Gly Leu Ile Gly Met Asn Gly Ser 
    50                  55                  60                  

Gly Lys Ser Thr Leu Leu Lys Leu Ile Ser Arg Ile Ile Tyr Pro Asp 
65                  70                  75                  80  

Lys Gly Glu Ile Arg Val His Gly Arg Val Ser Ser Leu Leu Glu Leu 
                85                  90                  95      

Gly Ala Gly Phe His Pro Glu Phe Thr Gly Leu Glu Asn Ile Tyr Met 
            100                 105                 110         

Asn Ala Ala Ile Leu Gly Leu Ser Lys Arg Glu Val Asp Lys Lys Leu 
        115                 120                 125             

Ala Glu Ile Val Glu Phe Ser Glu Leu Gly Asp Phe Leu Asn Glu Pro 
    130                 135                 140                 

Val Arg Ser Tyr Ser Ser Gly Met Tyr Met Arg Leu Ala Phe Ser Val 
145                 150                 155                 160 

Ala Val Ala Val Asp Pro Glu Ile Leu Leu Val Asp Glu Val Leu Ala 
                165                 170                 175     

Val Gly Asp Ala Ala Phe Gln Glu Lys Cys Leu Glu Arg Val Arg Arg 
            180                 185                 190         

Leu Arg Arg Glu Gly Lys Thr Ile Val Ile Val Thr His Asp Thr Gly 
        195                 200                 205             

Val Val Glu Gln Leu Cys Asp His Val Val Trp Leu His Asn Ser Arg 
    210                 215                 220                 

Val Arg Met Glu Gly Arg Pro Glu Glu Cys Ile Pro His Tyr Leu Asp 
225                 230                 235                 240 

Glu Ile Leu Gly Glu Arg Arg Gly Thr Gly Met Ser Phe Asp Arg Val 
                245                 250                 255     

Glu Gln Pro Pro Leu Gln Pro Gly Asp Glu Leu Lys Asp Leu Gly Leu 
            260                 265                 270         

Gly Leu Arg Val Gly Ile Arg Glu Asn Ala Glu Val Leu Pro Asn Asp 
        275                 280                 285             

Gly Gly Ile Arg Val Val Tyr Glu Ala Ser Ala Ala His Glu Val Cys 
    290                 295                 300                 

Cys Glu Ala Ser Val Val Ile Arg Arg Leu Gly Asp Pro Gln Glu Leu 
305                 310                 315                 320 

Arg Pro Arg Cys Asn Glu Lys Ile Ala Leu Pro Lys Gly His Ser Val 
                325                 330                 335     

Leu Glu Leu His Ala Thr Leu Asp Arg Ala Leu Tyr Pro Gly Asp Tyr 
            340                 345                 350         

Met Ile Glu Leu Val Leu Gln Val Asn Asp His Ile Leu Arg Ala Pro 
        355                 360                 365             

Ala Thr Arg Leu Trp Ile Pro His Ser Ser Gln Glu Glu Ser Leu Gln 
    370                 375                 380                 

Leu Gln Val Ser Val Gln Thr Ala 
385                 390         

<210>   250
<211>   392
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   250
Met Ala Thr Ser Ala Ile Glu Val Cys Asn Val Thr Lys Ser Phe Arg 
                5                   10                  15      

Val His Ile Gly Lys Asn Gln Thr Leu Lys Glu Lys Leu Phe Tyr Met 
            20                  25                  30          

Gly Lys Ser Lys Tyr Arg Asp Phe Ile Ala Leu Lys Asp Val Ser Val 
        35                  40                  45              

Arg Ile Pro Lys Gly Ala Thr Val Gly Leu Ile Gly Met Asn Gly Ser 
    50                  55                  60                  

Gly Lys Ser Thr Leu Leu Lys Leu Ile Ser Arg Ile Ile Tyr Pro Asp 
65                  70                  75                  80  

Lys Gly Glu Ile Lys Val His Gly Arg Val Ser Ser Leu Leu Glu Leu 
                85                  90                  95      

Gly Ala Gly Phe His Pro Glu Phe Thr Gly Leu Glu Asn Ile Tyr Met 
            100                 105                 110         

Asn Ala Ala Ile Leu Gly Leu Ser Lys Arg Glu Val Asp Lys Lys Leu 
        115                 120                 125             

Ala Glu Ile Val Glu Phe Ser Glu Leu Gly Asp Phe Leu Asn Glu Pro 
    130                 135                 140                 

Val Arg Ser Tyr Ser Ser Gly Met Tyr Met Arg Leu Ala Phe Ser Val 
145                 150                 155                 160 

Ala Val Ala Val Asp Pro Glu Ile Leu Leu Val Asp Glu Val Leu Ala 
                165                 170                 175     

Val Gly Asp Ala Ala Phe Gln Glu Lys Cys Leu Glu Arg Val Arg Arg 
            180                 185                 190         

Leu Arg Arg Glu Gly Lys Thr Ile Val Ile Val Thr His Asp Thr Gly 
        195                 200                 205             

Val Val Glu Gln Leu Cys Asp His Val Val Trp Leu His Asn Ser Arg 
    210                 215                 220                 

Val Arg Met Glu Gly Arg Pro Glu Glu Cys Ile Pro His Tyr Leu Asp 
225                 230                 235                 240 

Glu Ile Leu Gly Glu Arg Arg Gly Thr Gly Met Ser Phe Asp Arg Val 
                245                 250                 255     

Glu Gln Pro Pro Leu Gln Pro Gly Asp Glu Leu Lys Asp Leu Gly Leu 
            260                 265                 270         

Gly Leu Arg Val Gly Ile Arg Glu Asn Ala Glu Val Leu Pro Asn Asp 
        275                 280                 285             

Gly Gly Ile Arg Val Val Tyr Glu Ala Ser Ala Ala His Glu Val Cys 
    290                 295                 300                 

Cys Glu Ala Ser Val Val Ile Arg Arg Leu Gly Asp Pro Gln Glu Leu 
305                 310                 315                 320 

Arg Pro Arg Cys Asn Glu Lys Ile Ala Leu Pro Lys Gly His Ser Val 
                325                 330                 335     

Leu Glu Leu His Ala Thr Leu Asp Arg Ala Leu Tyr Pro Gly Glu Tyr 
            340                 345                 350         

Met Ile Glu Leu Val Leu Gln Val Asn Asp His Ile Leu Arg Ala Pro 
        355                 360                 365             

Ala Thr Arg Leu Trp Ile Pro His Ser Ser Gln Glu Glu Ser Leu Gln 
    370                 375                 380                 

Leu Gln Val Ser Val Gln Thr Ala 
385                 390         

<210>   251
<211>   1179
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   251
atggccacaa gtgctattga ggtatgcaat gtcaccaagt cgtttcgtgt ccatattggg       60

aaaaatcaga cgttaaaaga aaaattgttc tacatgggga agagcaagta tcgagatttt      120

atcgcgctca aagacgtgtc cgtgcgaatt cccaaaggag ccaccgttgg actcattggc      180

atgaacggtt caggtaagag tacgctctta aaactgatat ctcgcattat atatccagat      240

aaaggggaaa ttcgtgttca cggacgggtt tctagcttac tggagcttgg tgcaggcttt      300

catccggagt ttacggggtt agagaacatc tatatgaatg cagccatact gggattgtca      360

aagcgcgagg tggacaagaa gctggccgag atcgtcgagt tctctgagtt aggtgatttt      420

ctgaatgagc ccgttcgaag ctactcgtcg ggtatgtaca tgaggctcgc cttctctgtc      480

gcggtcgcgg tggatccgga aattttgctc gtggacgaag tattagcggt gggagacgct      540

gcttttcagg agaaatgcat tgaacgtgtc cgcaggttga gaagagaggg aaagacgatc      600

gtcattgtca cacacgacac gggagtcgtg gaacaattgt gcgatcacgt ggtctggtta      660

cataactcgc gcgttcgaat ggaagggcgg ccggaggaat gtatcccaca ttatctagac      720

gaaatcctag gagagcgtag gggaacgggc atgtcgtttg accgagtgga acaaccacct      780

ttgcaacccg gcgatgaact gaaggacttg ggtttgggat tacgtgtcgg cattcgagaa      840

aatgccgaag ttcttccgaa cgacggcggg attcgggtcg tctacgaggc gtcggccgcg      900

catgaggtct gctgtgaggc gagcgtcgtg attcggcgtc ttggcgaccc acaagaactt      960

cggcctaggt gcaacgaaaa gatcgcattg cctaaggggc attcagttct tgagttgcat     1020

gctactcttg atcgagcgtt gtaccctggg gagtatatga ttgaactcgt gttacaggta     1080

aatgatcaca tattgcgtgc acctgcaact cgtttgtgga tccctcattc ttcgcaagag     1140

gaaagtctgc aactgcaagt ctcggttcaa acggcctaa                            1179


<210>   252
<211>   1179
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   252
atggccacaa gtgctattga ggtatgcaat gtcaccaagt cgtttcgtgt ccatattggg       60

aaaaatcaga cgttaaaaga aaaattgttc tacatgggga agagcaagta tcgagatttt      120

atcgcgctca aagacgtgtc cgtgcgaatt cccaaaggag ccaccgttgg actcattggc      180

atgaacggtt caggtaagag tacgctctta aaactgatat ctcgcattat atatccagat      240

aaaggggaaa ttcgtgttca cggacgggtt tctagcttac tggagcttgg tgcaggcttt      300

catccggagt ttacggggtt agagaacatc tatatgaatg cagccatact gggattgtca      360

aagcgcgagg tggacaagaa gctggccgag atcgtcgagt tctctgagtt aggtgatttt      420

ctgaatgagc ccgttcgaag ctactcgtcg ggtatgtaca tgaggctcgc cttctctgtc      480

gcggtcgcgg tggatccgga aattttgctc gtggacgaag tattagcggt gggagacgct      540

gcttttcagg agaaatgcct tgaacgtgtc cgcaggttga gaagagaggg aaagacgatc      600

gtcattgtca cacacgacac gggagtcgtg gaacaattgt gcgatcacgt ggtctggtta      660

cataactcgc gcgttcgaat ggaagggcgg ccggaggaat gtatcccaca ttatctagac      720

gaaatcctag gagagcgtag gggaacgggc atgtcgtttg accgagtgga acaaccacct      780

ttgcaacccg gcgaagaact gaaggacttg ggtttgggat tacgtgtcgg cattcgagaa      840

aatgccgaag ttcttccgaa cgacggcggg attcgggtcg tctacgaggc gtcggccgcg      900

catgaggtct gctgtgaggc gagcgtcgtg attcggcgtc ttggcgaccc acaagaactt      960

cggcctaggt gcaacgaaaa gatcgcattg cctaaggggc attcagttct tgagttgcat     1020

gctactcttg atcgagcgtt gtaccctggg gagtatatga ttgaactcgt gttacaggta     1080

aatgatcaca tattgcgtgc acctgcaact cgtttgtgga tccctcattc ttcgcaagag     1140

gaaagtctgc aactgcaagt ctcggttcaa acggcctaa                            1179


<210>   253
<211>   1179
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   253
atggccacaa gtgctattga ggtatgcaat gtcaccaagt cgtttcgtgt ccatattggg       60

aaaaatcaga cgttaaaaga aaaattgttc tacatgggga agagcaagta tcgagatttt      120

atcgcgctca aagacgtgtc cgtgcgaatt cccaaaggag ccaccgttgg actcattggc      180

atgaacggtt caggtaagag tacgctctta aaactgatat ctcgcattat atatccagat      240

aaaggggaaa ttcgtgttca cggacgggtt tctagcttac tggagcttgg tgcaggcttt      300

catccggagt ttacggggtt agagaacatc tatatgaatg cagccatact gggattgtca      360

aagcgcgagg tggacaagaa gctggccgag atcgtcgagt tctctgagtt aggtgatttt      420

ctgaatgagc ccgttcgaag ctactcgtcg ggtatgtaca tgaggctcgc cttctctgtc      480

gcggtcgcgg tggatccgga aattttgctc gtggacgaag tattagcggt gggagacgct      540

gcttttcagg agaaatgcct tgaacgtgtc cgcaggttga gaagagaggg aaagacgatc      600

gtcattgtca cacacgacac gggagtcgtg gaacaattgt gcgatcacgt ggtctggtta      660

cataactcgc gcgttcgaat ggaagggcgg ccggaggaat gtatcccaca ttatctagac      720

gaaatcctag gagagcgtag gggaacgggc atgtcgtttg accgagtgga acaaccacct      780

ttgcaacccg gcgatgaact gaaggacttg ggtttgggat tacgtgtcgg cattcgagaa      840

caagccgaag ttcttccgaa cgacggcggg attcgggtcg tctacgaggc gtcggccgcg      900

catgaggtct gctgtgaggc gagcgtcgtg attcggcgtc ttggcgaccc acaagaactt      960

cggcctaggt gcaacgaaaa gatcgcattg cctaaggggc attcagttct tgagttgcat     1020

gctactcttg atcgagcgtt gtaccctggg gagtatatga ttgaactcgt gttacaggta     1080

aatgatcaca tattgcgtgc acctgcaact cgtttgtgga tccctcattc ttcgcaagag     1140

gaaagtctgc aactgcaagt ctcggttcaa acggcctaa                            1179


<210>   254
<211>   1179
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   254
atggccacaa gtgctattga ggtatgcaat gtcaccaagt cgtttcgtgt ccatattggg       60

aaaaatcaga cgttaaaaga aaaattgttc tacatgggga agagcaagta tcgagatttt      120

atcgcgctca aagacgtgtc cgtgcgaatt cccaaaggag ccaccgttgg actcattggc      180

atgaacggtt caggtaagag tacgctctta aaactgatat ctcgcattat atatccagat      240

aaaggggaaa ttcgtgttca cggacgggtt tctagcttac tggagcttgg tgcaggcttt      300

catccggagt ttacggggtt agagaacatc tatatgaatg cagccatact gggattgtca      360

aagcgcgagg tggacaagaa gctggccgag atcgtcgagt tctctgagtt aggtgatttt      420

ctgaatgagc ccgttcgaag ctactcgtcg ggtatgtaca tgaggctcgc cttctctgtc      480

gcggtcgcgg tggatccgga aattttgctc gtggacgaag tattagcggt gggagacgct      540

gcttttcagg agaaatgcct tgaacgtgtc cgcaggttga gaagagaggg aaagacgatc      600

gtcattgtca cacacgacac gggagtcgtg gaacaattgt gcgatcacgt ggtctggtta      660

cataactcgc gcgttcgaat ggaagggcgg ccggaggaat gtatcccaca ttatctagac      720

gaaatcctag gagagcgtag gggaacgggc atgtcgtttg accgagtgga acaaccacct      780

ttgcaacccg gcgatgaact gaaggacttg ggtttgggat tacgtgtcgg cattcgagaa      840

aatgccgaag ttcttccgaa cgacggcggg attcgggtcg tctacgaggc gtcggccgcg      900

catgaggtct gctgtgaggc gagcgtcgtg attcggcgtc ttggcgaccc acaagaactt      960

cggcctaggt gcaacgaaaa gatcgcattg cctaaggggc attcagttct tgagttgcat     1020

gctactcttg atcgagcgtt gtaccctggg gattatatga ttgaactcgt gttacaggta     1080

aatgatcaca tattgcgtgc acctgcaact cgtttgtgga tccctcattc ttcgcaagag     1140

gaaagtctgc aactgcaagt ctcggttcaa acggcctaa                            1179


<210>   255
<211>   1179
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   255
atggccacaa gtgctattga ggtatgcaat gtcaccaagt cgtttcgtgt ccatattggg       60

aaaaatcaga cgttaaaaga aaaattgttc tacatgggga agagcaagta tcgagatttt      120

atcgcgctca aagacgtgtc cgtgcgaatt cccaaaggag ccaccgttgg actcattggc      180

atgaacggtt caggtaagag tacgctctta aaactgatat ctcgcattat atatccagat      240

aaaggggaaa ttaaagttca cggacgggtt tctagcttac tggagcttgg tgcaggcttt      300

catccggagt ttacggggtt agagaacatc tatatgaatg cagccatact gggattgtca      360

aagcgcgagg tggacaagaa gctggccgag atcgtcgagt tctctgagtt aggtgatttt      420

ctgaatgagc ccgttcgaag ctactcgtcg ggtatgtaca tgaggctcgc cttctctgtc      480

gcggtcgcgg tggatccgga aattttgctc gtggacgaag tattagcggt gggagacgct      540

gcttttcagg agaaatgcct tgaacgtgtc cgcaggttga gaagagaggg aaagacgatc      600

gtcattgtca cacacgacac gggagtcgtg gaacaattgt gcgatcacgt ggtctggtta      660

cataactcgc gcgttcgaat ggaagggcgg ccggaggaat gtatcccaca ttatctagac      720

gaaatcctag gagagcgtag gggaacgggc atgtcgtttg accgagtgga acaaccacct      780

ttgcaacccg gcgatgaact gaaggacttg ggtttgggat tacgtgtcgg cattcgagaa      840

aatgccgaag ttcttccgaa cgacggcggg attcgggtcg tctacgaggc gtcggccgcg      900

catgaggtct gctgtgaggc gagcgtcgtg attcggcgtc ttggcgaccc acaagaactt      960

cggcctaggt gcaacgaaaa gatcgcattg cctaaggggc attcagttct tgagttgcat     1020

gctactcttg atcgagcgtt gtaccctggg gagtatatga ttgaactcgt gttacaggta     1080

aatgatcaca tattgcgtgc acctgcaact cgtttgtgga tccctcattc ttcgcaagag     1140

gaaagtctgc aactgcaagt ctcggttcaa acggcctaa                            1179


<210>   256
<211>   281
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   256
Met Thr Gly Thr Ile Arg Thr Arg Arg Gly Ile Val Leu Ala His Ala 
                5                   10                  15      

Val Leu Val Ile Ile Gly Phe Phe Leu Ile Tyr Pro Val Leu Trp Met 
            20                  25                  30          

Val Phe Gly Ser Phe Lys Pro Thr Asn Glu Ile Phe Ser Ser Ala Ser 
        35                  40                  45              

Phe Trp Pro Lys His Trp Thr Phe Ala Asn Tyr Pro Gln Gly Trp Asn 
    50                  55                  60                  

Ala Ile Pro Gly Leu Pro Phe Gly Thr Phe Ile Leu His Ser Leu Ser 
65                  70                  75                  80  

Val Ser Cys Leu Val Ser Val Gly Thr Val Ile Ser Ser Ala Ile Val 
                85                  90                  95      

Ala Phe Gly Phe Ala Arg Phe Thr Phe Arg Gly Lys Ser Ile Leu Phe 
            100                 105                 110         

Gly Ile Met Met Ile Thr Met Met Leu Pro Thr Gln Val Thr Leu Ile 
        115                 120                 125             

Pro Gln Tyr Ala Met Phe His Asp Leu Gly Trp Ile Asn Thr Tyr Tyr 
    130                 135                 140                 

Pro Leu Ile Val Pro Ala Phe Phe Gly Ser Pro Phe Phe Ile Phe Leu 
145                 150                 155                 160 

Ile Val Gln Phe Ile Arg Gly Leu Pro Lys Glu Leu Asp Glu Ala Ala 
                165                 170                 175     

Lys Ile Asp Gly Cys Asn Ala Phe Thr Leu Phe Val Arg Val Ile Leu 
            180                 185                 190         

Pro Leu Ile Val Pro Ala Leu Ile Thr Thr Ala Ile Phe Ser Phe Ile 
        195                 200                 205             

Trp Cys Trp Asp Asp Phe Phe Ser Gln Leu Ile Tyr Leu Asn Ser Ala 
    210                 215                 220                 

Gln Lys Phe Thr Val Pro Leu Gly Leu Glu Ser Leu Ala Asn Ala Val 
225                 230                 235                 240 

Ala Gln Glu Glu Trp Gly Pro Leu Phe Ala Met Ser Thr Val Ser Leu 
                245                 250                 255     

Ile Pro Leu Phe Leu Ile Phe Phe Phe Leu Gln Lys Tyr Val Val Arg 
            260                 265                 270         

Gly Ile Ala Thr Thr Gly Leu Arg Gly 
        275                 280     

<210>   257
<211>   846
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   257
gtgaccggaa ccatccgcac gcggcgcgga atcgtcctcg cgcacgccgt gctcgtgatc       60

atcggattct ttctcatcta tcccgttctc tggatggtgt ttggctcatt caagccgacc      120

aacgagatct tctccagcgc ctcgttttgg cccaagcact ggacgttcgc gaattatccg      180

caaggttgga atgcgattcc tggccttccg tttgggacgt tcatcctgca ttcgctgtcg      240

gtgtcatgtc tggtgtctgt cggcacggtc atctcgtccg cgattgtcgc gttcgggttc      300

gcgcgtttca cgttccgagg caaatccatt ctgtttggca tcatgatgat cacgatgatg      360

ctgccgacgc aggtcacgct cattccccag tacgcgatgt ttcacgatct gggctggatc      420

aatacctact atccgctcat tgtgcccgcg ttctttggca gcccgttttt catctttctc      480

atcgttcaat tcatccgggg gttgcccaaa gaattggacg aggccgcgaa gatcgacggc      540

tgcaacgcct tcacgctgtt tgtgcgcgtc atcctgccgc tcatcgtgcc ggcgctcatc      600

accacggcca tcttcagctt catctggtgc tgggatgact tcttctctca gttgatttac      660

cttaattccg cgcagaagtt caccgtgccg ctcgggctgg agtcgctcgc gaacgccgtc      720

gcgcaggagg agtgggggcc gctcttcgcc atgtccaccg tgtcgctcat tccgctcttc      780

ctcatcttct tcttccttca gaagtacgtc gtccgcggca tcgccaccac gggcctgcgc      840

ggctga                                                                 846


<210>   258
<211>   277
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   258
Arg Thr Lys Thr Ala Asp Ala Ile Tyr Tyr Thr Phe Val Ile Leu Phe 
                5                   10                  15      

Gly Phe Val Met Leu Tyr Pro Ile Leu Trp Met Val Ala Ser Ser Leu 
            20                  25                  30          

Lys Pro Gln Thr Glu Ile Phe Gly Asn Ala Ala Ser Leu Trp Pro Gly 
        35                  40                  45              

Glu Phe Met Trp Glu Asn Tyr Ala Lys Gly Trp Glu Gly Phe Gly Arg 
    50                  55                  60                  

Thr Gly Phe Asp Val Tyr Phe Ser Asn Ser Ile Phe Ile Thr Thr Leu 
65                  70                  75                  80  

Ser Val Ile Gly Ala Ile Leu Ser Ser Ser Ile Val Ala Tyr Gly Phe 
                85                  90                  95      

Ala Arg Leu Gln Phe Arg Phe Lys Lys Ile Leu Phe Ala Cys Leu Leu 
            100                 105                 110         

Gly Thr Val Met Leu Pro Val Gln Ile Thr Leu Ile Pro Gln Tyr Ile 
        115                 120                 125             

Met Phe His Asn Ile Gly Trp Val Asn Thr Phe Tyr Pro Leu Ile Val 
    130                 135                 140                 

Pro Ala Phe Leu Gly Gly Thr Pro Phe Phe Ile Phe Leu Leu Ile Gln 
145                 150                 155                 160 

Phe Ile Arg Gly Ile Pro Arg Glu Leu Asp Glu Ala Ala Ile Ile Asp 
                165                 170                 175     

Gly Cys Ser Thr Phe Gly Ile Phe Trp Arg Ile Ile Leu Pro Leu Ile 
            180                 185                 190         

Lys Pro Ala Leu Val Thr Val Ala Ile Phe Ala Phe Met Trp Ala Trp 
        195                 200                 205             

Asp Asp Phe Leu Ala Pro Leu Ile Tyr Leu Asn Ser Ala Asp Ile Gln 
    210                 215                 220                 

Thr Val Ser Leu Gly Leu Arg Asn Phe Met Asp Ala Glu Gly Gly Thr 
225                 230                 235                 240 

Ser Trp Gly Pro Leu Leu Ala Met Ser Thr Leu Ser Leu Leu Pro Gln 
                245                 250                 255     

Phe Ile Ile Phe Leu Phe Phe Gln Lys His Leu Val Glu Gly Ile Ala 
            260                 265                 270         

Thr Thr Gly Leu Lys 
        275         

<210>   259
<211>   279
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   259
Thr Lys Arg Thr Trp Tyr Ala Asp Val Ile Tyr Tyr Gly Phe Val Ile 
                5                   10                  15      

Ala Phe Gly Phe Ile Met Val Tyr Pro Ile Leu Trp Met Val Ala Ser 
            20                  25                  30          

Ser Leu Lys Pro Ala Ser Glu Ile Phe Ser Gln Ala Ser Ser Leu Ile 
        35                  40                  45              

Pro Ser Glu Phe Val Trp Ser Asn Tyr Pro Asp Gly Trp Ala Gly Phe 
    50                  55                  60                  

Gly Arg Thr Gly Phe Asp Ile Tyr Phe Lys Asn Ser Phe Ile Ile Thr 
65                  70                  75                  80  

Thr Ser Val Val Ile Gly Ala Ile Leu Ser Ser Ser Ile Val Ala Tyr 
                85                  90                  95      

Gly Phe Ala Arg Leu Gln Phe Lys Phe Lys Lys Val Leu Phe Ala Cys 
            100                 105                 110         

Leu Ile Ala Thr Val Met Leu Pro Val Gln Ile Thr Leu Ile Pro Gln 
        115                 120                 125             

Tyr Ile Leu Phe His Asn Leu Gly Trp Val Asn Thr Phe Tyr Pro Leu 
    130                 135                 140                 

Ile Val Pro Ala Phe Leu Gly Gly Thr Pro Phe Phe Ile Phe Leu Leu 
145                 150                 155                 160 

Ile Gln Phe Ile Arg Gly Ile Pro Arg Glu Leu Asp Glu Ala Ala Ile 
                165                 170                 175     

Ile Asp Gly Cys Ser Thr Phe Gly Val Phe Trp Arg Val Ile Leu Pro 
            180                 185                 190         

Leu Leu Lys Pro Ala Leu Val Thr Val Ala Ile Phe Ala Phe Met Trp 
        195                 200                 205             

Thr Trp Asp Asp Phe Leu Ala Pro Leu Ile Tyr Leu Asn Lys Thr Asp 
    210                 215                 220                 

Ile Gln Thr Val Ala Leu Gly Leu Arg Asn Phe Met Asp Ala Glu Ser 
225                 230                 235                 240 

Gly Thr Ser Trp Gly Ala Leu Leu Ala Met Ser Thr Leu Ser Leu Leu 
                245                 250                 255     

Pro Gln Phe Ile Ile Phe Leu Phe Phe Gln Arg Tyr Leu Val Glu Gly 
            260                 265                 270         

Ile Ser Thr Thr Gly Leu Lys 
        275                 

<210>   260
<211>   271
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   260
Leu Leu Leu His Val Ile Ile Ile Ala Ile Gly Leu Val Met Leu Tyr 
                5                   10                  15      

Pro Leu Leu Trp Met Val Ser Ser Ser Phe Lys Glu Pro Thr Glu Ile 
            20                  25                  30          

Phe Lys Gly Val Ser Phe Leu Pro Thr Asn Phe Asn Phe Asp Asn Tyr 
        35                  40                  45              

Ile Glu Gly Trp Thr Gly Leu Ser Gly Val Ser Phe Gly Arg Phe Phe 
    50                  55                  60                  

Leu Asn Thr Phe Ile Leu Val Ile Phe Cys Thr Ile Gly Thr Val Phe 
65                  70                  75                  80  

Ser Cys Ser Met Ala Ala Tyr Ala Phe Ala Arg Leu Asp Phe Lys Phe 
                85                  90                  95      

Lys Lys Val Leu Phe Gly Val Met Leu Val Thr Met Met Leu Pro Phe 
            100                 105                 110         

His Val Thr Val Ile Pro Gln Tyr Ile Met Phe Asn Lys Leu Glu Trp 
        115                 120                 125             

Ile Asn Thr Tyr Ile Pro Leu Ile Leu Pro Lys Phe Leu Ala Val Asp 
    130                 135                 140                 

Gly Phe Phe Ile Phe Leu Met Val Gln Phe Ile Arg Ser Ile Pro Lys 
145                 150                 155                 160 

Glu Leu Asp Glu Ala Ala Lys Met Asp Gly Cys Gly Pro Ile Arg Met 
                165                 170                 175     

Phe Tyr Thr Leu Ile Met Pro Leu Ala Leu Pro Ala Val Ile Thr Thr 
            180                 185                 190         

Val Ile Phe Thr Phe Ile Trp Thr Trp Asn Asp Phe Phe Ser Gln Leu 
        195                 200                 205             

Leu Tyr Leu Ser Asp Ile Lys Leu Tyr Thr Val Ala Leu Gly Leu Arg 
    210                 215                 220                 

Met Phe Leu Asp Ala Met Gly Gln Asn Ser Trp Gly Ala Leu Phe Ala 
225                 230                 235                 240 

Met Ser Thr Leu Ser Leu Ile Pro Leu Phe Ile Ile Phe Ile Phe Phe 
                245                 250                 255     

Gln Lys Tyr Leu Ile Glu Gly Ile Thr Ala Gly Gly Val Lys Gly 
            260                 265                 270     

<210>   261
<211>   273
<212>   PRT
<213>   Clostridium bolteae ATCC BAA-613

<400>   261
Gly Ile Thr Ile Tyr His Ile Leu Val Cys Ile Gly Gly Leu Ile Met 
                5                   10                  15      

Val Tyr Pro Leu Ile Trp Met Leu Met Ser Ser Phe Lys Glu Thr Asn 
            20                  25                  30          

Thr Ile Phe Ala Thr Ala Lys Glu Leu Leu Pro Glu Lys Ala Thr Leu 
        35                  40                  45              

Val Asn Tyr Val Asn Gly Trp Lys Gly Phe Ala Gly Ser Thr Phe Gly 
    50                  55                  60                  

Arg Phe Phe Ala Asn Ser Ala Ile Ile Ser Val Leu Ser Thr Val Gly 
65                  70                  75                  80  

Ala Val Ala Ser Ser Ala Ile Val Gly Tyr Gly Phe Ala Arg Cys Arg 
                85                  90                  95      

Phe Lys Gly Lys Lys Leu Leu Phe Thr Cys Met Met Val Ser Met Met 
            100                 105                 110         

Leu Pro Phe Gln Val Met Met Ile Pro Gln Phe Ile Trp Phe Lys Lys 
        115                 120                 125             

Leu Gly Trp Val Gly Thr Tyr Leu Pro Leu Ile Ala Pro Tyr Phe Phe 
    130                 135                 140                 

Gly Gln Gly Phe Phe Ile Phe Leu Ile Met Gln Phe Ile Glu Gly Ile 
145                 150                 155                 160 

Pro Arg Glu Leu Asp Glu Ala Ala Lys Ile Asp Gly Cys Ser Tyr Tyr 
                165                 170                 175     

Gly Val Phe Arg Gln Ile Ile Leu Pro Leu Ile Ile Pro Ala Leu Ile 
            180                 185                 190         

Thr Ser Gly Ile Phe Ser Phe Ile Trp Arg Trp Asp Asp Phe Met Ser 
        195                 200                 205             

Pro Leu Leu Tyr Ile Asn Lys Thr Thr Met Tyr Pro Ile Ser Tyr Ala 
    210                 215                 220                 

Leu Lys Leu Phe Cys Asp Pro Ser Ser Thr Ser Asp Tyr Gly Ala Met 
225                 230                 235                 240 

Phe Ala Met Ala Thr Leu Ser Leu Leu Pro Ala Val Ile Ile Phe Ile 
                245                 250                 255     

Thr Leu Gln Lys Tyr Leu Val Glu Gly Ile Ala Thr Ser Gly Ile Lys 
            260                 265                 270         

Gly 
    

<210>   262
<211>   270
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   262
Leu Tyr His Phe Thr Val Leu Leu Phe Gly Phe Phe Met Leu Tyr Pro 
                5                   10                  15      

Val Leu Trp Met Ile Ser Ser Ser Val Lys Pro Pro Ala Glu Ile Phe 
            20                  25                  30          

Gln Gln Ala Ala Ser Leu Leu Pro Ser Ala Phe His Trp Asp Asn Tyr 
        35                  40                  45              

Val Glu Gly Trp Lys Gly Phe Gly Ser Val Gly Phe Asp Gln Ile Phe 
    50                  55                  60                  

Arg Asn Ser Leu Phe Val Ser Ser Met Asn Ile Ile Gly Ala Leu Ile 
65                  70                  75                  80  

Ser Ser Ser Phe Val Ala Phe Gly Phe Ala Arg Leu Lys Phe Pro Leu 
                85                  90                  95      

Lys Asn Ile Leu Phe Ala Cys Leu Ile Gly Thr Leu Met Leu Pro Met 
            100                 105                 110         

Gln Ile Thr Leu Ile Pro Gln Tyr Ile Leu Phe Asn Tyr Phe Gly Trp 
        115                 120                 125             

Val Asn Thr Phe Leu Pro Leu Ile Val Pro Ala Phe Val Gly Gly Thr 
    130                 135                 140                 

Pro Phe Phe Ile Phe Leu Met Val Gln Phe Ile Arg Gly Ile Pro Arg 
145                 150                 155                 160 

Glu Leu Asp Glu Ala Ala Val Ile Asp Gly Cys Ser Thr Leu Gly Ile 
                165                 170                 175     

Phe Trp Arg Ile Ile Met Pro Leu Cys Lys Pro Val Leu Val Thr Val 
            180                 185                 190         

Thr Ile Phe Ala Phe Leu Trp Ser Trp Asp Asp Phe Phe Gly Gly Leu 
        195                 200                 205             

Ile Tyr Leu Asn Asp Pro Ser Leu Tyr Thr Val Gly Leu Gly Leu Ala 
    210                 215                 220                 

Ser Phe Leu Asp Ser Thr Ser Ala Ser Ser Trp Gly Pro Leu Leu Ala 
225                 230                 235                 240 

Met Ala Thr Leu Ser Leu Val Pro Gln Phe Ile Val Phe Leu Phe Phe 
                245                 250                 255     

Gln Lys Tyr Leu Val Gln Gly Ile Ala Thr Thr Gly Ile Lys 
            260                 265                 270 

<210>   263
<211>   281
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   263
Met Thr Gly Thr Ile Arg Thr Arg Arg Gly Ile Val Leu Ala His Ala 
                5                   10                  15      

Val Leu Val Ile Ile Gly Phe Phe Leu Ile Tyr Pro Val Leu Trp Met 
            20                  25                  30          

Val Phe Gly Ser Phe Lys Pro Thr Asn Glu Ile Phe Ser Ser Ala Ser 
        35                  40                  45              

Phe Trp Pro Lys His Trp Thr Phe Ala Asn Tyr Pro Gln Gly Trp Asn 
    50                  55                  60                  

Ala Ile Pro Gly Leu Pro Phe Gly Thr Phe Ile Leu His Ser Leu Ser 
65                  70                  75                  80  

Val Ser Cys Leu Val Ser Val Gly Thr Val Ile Ser Ser Ala Ile Val 
                85                  90                  95      

Ala Phe Gly Phe Ala Arg Phe Thr Phe Arg Gly Lys Ser Ile Leu Phe 
            100                 105                 110         

Gly Ile Met Met Ile Thr Met Met Leu Pro Thr Gln Val Thr Leu Ile 
        115                 120                 125             

Pro Gln Tyr Ala Met Phe His Asp Leu Gly Trp Ile Asn Thr Tyr Tyr 
    130                 135                 140                 

Pro Leu Ile Val Pro Ala Phe Phe Gly Ser Pro Phe Phe Ile Phe Leu 
145                 150                 155                 160 

Ile Val Gln Phe Ile Arg Gly Leu Pro Lys Glu Leu Asp Glu Ala Ala 
                165                 170                 175     

Lys Ile Asp Gly Cys Asn Ala Phe Thr Ile Phe Val Arg Val Ile Leu 
            180                 185                 190         

Pro Leu Ile Val Pro Ala Leu Ile Thr Thr Ala Ile Phe Ser Phe Ile 
        195                 200                 205             

Trp Cys Trp Asp Asp Phe Phe Ser Gln Leu Ile Tyr Leu Asn Ser Ala 
    210                 215                 220                 

Gln Lys Phe Thr Val Pro Leu Gly Leu Glu Ser Leu Ala Asn Ala Val 
225                 230                 235                 240 

Ala Gln Glu Glu Trp Gly Pro Leu Phe Ala Met Ser Thr Val Ser Leu 
                245                 250                 255     

Ile Pro Leu Phe Leu Ile Phe Phe Phe Leu Gln Lys Tyr Val Val Arg 
            260                 265                 270         

Gly Ile Ala Thr Thr Gly Leu Arg Gly 
        275                 280     

<210>   264
<211>   281
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   264
Met Thr Gly Thr Ile Arg Thr Arg Arg Gly Ile Val Leu Ala His Ala 
                5                   10                  15      

Val Leu Val Ile Ile Gly Phe Phe Leu Ile Tyr Pro Val Leu Trp Met 
            20                  25                  30          

Val Phe Gly Ser Phe Lys Pro Thr Asn Glu Ile Phe Ser Ser Ala Ser 
        35                  40                  45              

Phe Trp Pro Lys His Trp Thr Phe Ala Asn Tyr Pro Gln Gly Trp Asn 
    50                  55                  60                  

Ala Ile Pro Gly Leu Pro Phe Gly Thr Phe Ile Leu His Ser Leu Ser 
65                  70                  75                  80  

Val Ser Cys Leu Val Ser Val Gly Thr Val Ile Ser Ser Ala Ile Val 
                85                  90                  95      

Ala Phe Gly Phe Ala Arg Phe Thr Phe Arg Gly Lys Ser Ile Leu Phe 
            100                 105                 110         

Gly Ile Met Met Ile Thr Met Met Leu Pro Thr Gln Val Thr Leu Ile 
        115                 120                 125             

Pro Gln Tyr Ala Met Phe His Asp Leu Gly Trp Ile Asn Thr Tyr Tyr 
    130                 135                 140                 

Pro Leu Ile Val Pro Ala Phe Phe Gly Ser Pro Phe Phe Ile Phe Leu 
145                 150                 155                 160 

Ile Val Gln Phe Ile Arg Gly Leu Pro Lys Glu Leu Asp Glu Ala Ala 
                165                 170                 175     

Lys Ile Asp Gly Cys Asn Ala Phe Thr Leu Phe Val Arg Val Ile Leu 
            180                 185                 190         

Pro Leu Ile Val Pro Ala Leu Ile Thr Thr Ala Ile Phe Ser Phe Ile 
        195                 200                 205             

Trp Cys Trp Asp Asp Phe Phe Ser Gln Leu Ile Tyr Leu Asn Ser Ala 
    210                 215                 220                 

Gln Lys Phe Thr Val Pro Leu Gly Leu Glu Ser Leu Ala Asn Ala Ile 
225                 230                 235                 240 

Ala Gln Glu Glu Trp Gly Pro Leu Phe Ala Met Ser Thr Val Ser Leu 
                245                 250                 255     

Ile Pro Leu Phe Leu Ile Phe Phe Phe Leu Gln Lys Tyr Val Val Arg 
            260                 265                 270         

Gly Ile Ala Thr Thr Gly Leu Arg Gly 
        275                 280     

<210>   265
<211>   281
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   265
Met Thr Gly Thr Ile Arg Thr Arg Arg Gly Ile Val Leu Ala His Ala 
                5                   10                  15      

Val Leu Val Ile Ile Gly Phe Phe Leu Ile Tyr Pro Val Leu Trp Met 
            20                  25                  30          

Val Phe Gly Ser Phe Lys Pro Thr Asn Glu Ile Phe Ser Ser Ala Ser 
        35                  40                  45              

Phe Trp Pro Lys His Trp Thr Phe Ala Asn Tyr Pro Gln Gly Trp Asn 
    50                  55                  60                  

Ala Ile Pro Gly Leu Pro Phe Gly Thr Phe Ile Leu His Ser Leu Ser 
65                  70                  75                  80  

Val Ser Cys Leu Val Ser Ile Gly Thr Val Ile Ser Ser Ala Ile Val 
                85                  90                  95      

Ala Phe Gly Phe Ala Arg Phe Thr Phe Arg Gly Lys Ser Ile Leu Phe 
            100                 105                 110         

Gly Ile Met Met Ile Thr Met Met Leu Pro Thr Gln Val Thr Leu Ile 
        115                 120                 125             

Pro Gln Tyr Ala Met Phe His Asp Leu Gly Trp Ile Asn Thr Tyr Tyr 
    130                 135                 140                 

Pro Leu Ile Val Pro Ala Phe Phe Gly Ser Pro Phe Phe Ile Phe Leu 
145                 150                 155                 160 

Ile Val Gln Phe Ile Arg Gly Leu Pro Lys Glu Leu Asp Glu Ala Ala 
                165                 170                 175     

Lys Ile Asp Gly Cys Asn Ala Phe Thr Leu Phe Val Arg Val Ile Leu 
            180                 185                 190         

Pro Leu Ile Val Pro Ala Leu Ile Thr Thr Ala Ile Phe Ser Phe Ile 
        195                 200                 205             

Trp Cys Trp Asp Asp Phe Phe Ser Gln Leu Ile Tyr Leu Asn Ser Ala 
    210                 215                 220                 

Gln Lys Phe Thr Val Pro Leu Gly Leu Glu Ser Leu Ala Asn Ala Val 
225                 230                 235                 240 

Ala Gln Glu Glu Trp Gly Pro Leu Phe Ala Met Ser Thr Val Ser Leu 
                245                 250                 255     

Ile Pro Leu Phe Leu Ile Phe Phe Phe Leu Gln Lys Tyr Val Val Arg 
            260                 265                 270         

Gly Ile Ala Thr Thr Gly Leu Arg Gly 
        275                 280     

<210>   266
<211>   281
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   266
Met Thr Gly Thr Ile Arg Thr Arg Arg Gly Ile Val Leu Ala His Ala 
                5                   10                  15      

Val Leu Val Ile Ile Gly Phe Phe Leu Ile Tyr Pro Val Leu Trp Met 
            20                  25                  30          

Val Phe Gly Ser Phe Lys Pro Thr Asn Glu Ile Phe Ser Ser Ala Ser 
        35                  40                  45              

Phe Trp Pro Lys His Trp Thr Phe Ala Asn Tyr Pro Gln Gly Trp Asn 
    50                  55                  60                  

Ala Ile Pro Gly Leu Pro Phe Gly Thr Phe Ile Leu His Ser Leu Ser 
65                  70                  75                  80  

Val Ser Cys Leu Val Ser Val Gly Thr Val Ile Ser Ser Ala Ile Val 
                85                  90                  95      

Ala Phe Gly Phe Ala Arg Phe Thr Phe Arg Gly Lys Ser Ile Leu Phe 
            100                 105                 110         

Gly Leu Met Met Ile Thr Met Met Leu Pro Thr Gln Val Thr Leu Ile 
        115                 120                 125             

Pro Gln Tyr Ala Met Phe His Asp Leu Gly Trp Ile Asn Thr Tyr Tyr 
    130                 135                 140                 

Pro Leu Ile Val Pro Ala Phe Phe Gly Ser Pro Phe Phe Ile Phe Leu 
145                 150                 155                 160 

Ile Val Gln Phe Ile Arg Gly Leu Pro Lys Glu Leu Asp Glu Ala Ala 
                165                 170                 175     

Lys Ile Asp Gly Cys Asn Ala Phe Thr Leu Phe Val Arg Val Ile Leu 
            180                 185                 190         

Pro Leu Ile Val Pro Ala Leu Ile Thr Thr Ala Ile Phe Ser Phe Ile 
        195                 200                 205             

Trp Cys Trp Asp Asp Phe Phe Ser Gln Leu Ile Tyr Leu Asn Ser Ala 
    210                 215                 220                 

Gln Lys Phe Thr Val Pro Leu Gly Leu Glu Ser Leu Ala Asn Ala Val 
225                 230                 235                 240 

Ala Gln Glu Glu Trp Gly Pro Leu Phe Ala Met Ser Thr Val Ser Leu 
                245                 250                 255     

Ile Pro Leu Phe Leu Ile Phe Phe Phe Leu Gln Lys Tyr Val Val Arg 
            260                 265                 270         

Gly Ile Ala Thr Thr Gly Leu Arg Gly 
        275                 280     

<210>   267
<211>   281
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   267
Met Thr Gly Thr Ile Arg Thr Arg Arg Gly Ile Val Leu Ala His Ala 
                5                   10                  15      

Val Leu Val Ile Ile Gly Phe Phe Leu Ile Tyr Pro Val Leu Trp Met 
            20                  25                  30          

Ile Phe Gly Ser Phe Lys Pro Thr Asn Glu Ile Phe Ser Ser Ala Ser 
        35                  40                  45              

Phe Trp Pro Lys His Trp Thr Phe Ala Asn Tyr Pro Gln Gly Trp Asn 
    50                  55                  60                  

Ala Ile Pro Gly Leu Pro Phe Gly Thr Phe Ile Leu His Ser Leu Ser 
65                  70                  75                  80  

Val Ser Cys Leu Val Ser Val Gly Thr Val Ile Ser Ser Ala Ile Val 
                85                  90                  95      

Ala Phe Gly Phe Ala Arg Phe Thr Phe Arg Gly Lys Ser Ile Leu Phe 
            100                 105                 110         

Gly Ile Met Met Ile Thr Met Met Leu Pro Thr Gln Val Thr Leu Ile 
        115                 120                 125             

Pro Gln Tyr Ala Met Phe His Asp Leu Gly Trp Ile Asn Thr Tyr Tyr 
    130                 135                 140                 

Pro Leu Ile Val Pro Ala Phe Phe Gly Ser Pro Phe Phe Ile Phe Leu 
145                 150                 155                 160 

Ile Val Gln Phe Ile Arg Gly Leu Pro Lys Glu Leu Asp Glu Ala Ala 
                165                 170                 175     

Lys Ile Asp Gly Cys Asn Ala Phe Thr Leu Phe Val Arg Val Ile Leu 
            180                 185                 190         

Pro Leu Ile Val Pro Ala Leu Ile Thr Thr Ala Ile Phe Ser Phe Ile 
        195                 200                 205             

Trp Cys Trp Asp Asp Phe Phe Ser Gln Leu Ile Tyr Leu Asn Ser Ala 
    210                 215                 220                 

Gln Lys Phe Thr Val Pro Leu Gly Leu Glu Ser Leu Ala Asn Ala Val 
225                 230                 235                 240 

Ala Gln Glu Glu Trp Gly Pro Leu Phe Ala Met Ser Thr Val Ser Leu 
                245                 250                 255     

Ile Pro Leu Phe Leu Ile Phe Phe Phe Leu Gln Lys Tyr Val Val Arg 
            260                 265                 270         

Gly Ile Ala Thr Thr Gly Leu Arg Gly 
        275                 280     

<210>   268
<211>   846
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   268
gtgaccggaa ccatccgcac gcggcgcgga atcgtcctcg cgcacgccgt gctcgtgatc       60

atcggattct ttctcatcta tcccgttctc tggatggtgt ttggctcatt caagccgacc      120

aacgagatct tctccagcgc ctcgttttgg cccaagcact ggacgttcgc gaattatccg      180

caaggttgga atgcgattcc tggccttccg tttgggacgt tcatcctgca ttcgctgtcg      240

gtgtcatgtc tggtgtctgt cggcacggtc atctcgtccg cgattgtcgc gttcgggttc      300

gcgcgtttca cgttccgagg caaatccatt ctgtttggca tcatgatgat cacgatgatg      360

ctgccgacgc aggtcacgct cattccccag tacgcgatgt ttcacgatct gggctggatc      420

aatacctact atccgctcat tgtgcccgcg ttctttggca gcccgttttt catctttctc      480

atcgttcaat tcatccgggg gttgcccaaa gaattggacg aggccgcgaa gatcgacggc      540

tgcaacgcct tcacgatttt tgtgcgcgtc atcctgccgc tcatcgtgcc ggcgctcatc      600

accacggcca tcttcagctt catctggtgc tgggatgact tcttctctca gttgatttac      660

cttaattccg cgcagaagtt caccgtgccg ctcgggctgg agtcgctcgc gaacgccgtc      720

gcgcaggagg agtgggggcc gctcttcgcc atgtccaccg tgtcgctcat tccgctcttc      780

ctcatcttct tcttccttca gaagtacgtc gtccgcggca tcgccaccac gggcctgcgc      840

ggctga                                                                 846


<210>   269
<211>   846
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   269
gtgaccggaa ccatccgcac gcggcgcgga atcgtcctcg cgcacgccgt gctcgtgatc       60

atcggattct ttctcatcta tcccgttctc tggatggtgt ttggctcatt caagccgacc      120

aacgagatct tctccagcgc ctcgttttgg cccaagcact ggacgttcgc gaattatccg      180

caaggttgga atgcgattcc tggccttccg tttgggacgt tcatcctgca ttcgctgtcg      240

gtgtcatgtc tggtgtctgt cggcacggtc atctcgtccg cgattgtcgc gttcgggttc      300

gcgcgtttca cgttccgagg caaatccatt ctgtttggca tcatgatgat cacgatgatg      360

ctgccgacgc aggtcacgct cattccccag tacgcgatgt ttcacgatct gggctggatc      420

aatacctact atccgctcat tgtgcccgcg ttctttggca gcccgttttt catctttctc      480

atcgttcaat tcatccgggg gttgcccaaa gaattggacg aggccgcgaa gatcgacggc      540

tgcaacgcct tcacgctgtt tgtgcgcgtc atcctgccgc tcatcgtgcc ggcgctcatc      600

accacggcca tcttcagctt catctggtgc tgggatgact tcttctctca gttgatttac      660

cttaattccg cgcagaagtt caccgtgccg ctcgggctgg agtcgctcgc gaacgccatt      720

gcgcaggagg agtgggggcc gctcttcgcc atgtccaccg tgtcgctcat tccgctcttc      780

ctcatcttct tcttccttca gaagtacgtc gtccgcggca tcgccaccac gggcctgcgc      840

ggctga                                                                 846


<210>   270
<211>   846
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   270
gtgaccggaa ccatccgcac gcggcgcgga atcgtcctcg cgcacgccgt gctcgtgatc       60

atcggattct ttctcatcta tcccgttctc tggatggtgt ttggctcatt caagccgacc      120

aacgagatct tctccagcgc ctcgttttgg cccaagcact ggacgttcgc gaattatccg      180

caaggttgga atgcgattcc tggccttccg tttgggacgt tcatcctgca ttcgctgtcg      240

gtgtcatgtc tggtgtctat tggcacggtc atctcgtccg cgattgtcgc gttcgggttc      300

gcgcgtttca cgttccgagg caaatccatt ctgtttggca tcatgatgat cacgatgatg      360

ctgccgacgc aggtcacgct cattccccag tacgcgatgt ttcacgatct gggctggatc      420

aatacctact atccgctcat tgtgcccgcg ttctttggca gcccgttttt catctttctc      480

atcgttcaat tcatccgggg gttgcccaaa gaattggacg aggccgcgaa gatcgacggc      540

tgcaacgcct tcacgctgtt tgtgcgcgtc atcctgccgc tcatcgtgcc ggcgctcatc      600

accacggcca tcttcagctt catctggtgc tgggatgact tcttctctca gttgatttac      660

cttaattccg cgcagaagtt caccgtgccg ctcgggctgg agtcgctcgc gaacgccgtc      720

gcgcaggagg agtgggggcc gctcttcgcc atgtccaccg tgtcgctcat tccgctcttc      780

ctcatcttct tcttccttca gaagtacgtc gtccgcggca tcgccaccac gggcctgcgc      840

ggctga                                                                 846


<210>   271
<211>   846
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   271
gtgaccggaa ccatccgcac gcggcgcgga atcgtcctcg cgcacgccgt gctcgtgatc       60

atcggattct ttctcatcta tcccgttctc tggatggtgt ttggctcatt caagccgacc      120

aacgagatct tctccagcgc ctcgttttgg cccaagcact ggacgttcgc gaattatccg      180

caaggttgga atgcgattcc tggccttccg tttgggacgt tcatcctgca ttcgctgtcg      240

gtgtcatgtc tggtgtctgt cggcacggtc atctcgtccg cgattgtcgc gttcgggttc      300

gcgcgtttca cgttccgagg caaatccatt ctgtttggct taatgatgat cacgatgatg      360

ctgccgacgc aggtcacgct cattccccag tacgcgatgt ttcacgatct gggctggatc      420

aatacctact atccgctcat tgtgcccgcg ttctttggca gcccgttttt catctttctc      480

atcgttcaat tcatccgggg gttgcccaaa gaattggacg aggccgcgaa gatcgacggc      540

tgcaacgcct tcacgctgtt tgtgcgcgtc atcctgccgc tcatcgtgcc ggcgctcatc      600

accacggcca tcttcagctt catctggtgc tgggatgact tcttctctca gttgatttac      660

cttaattccg cgcagaagtt caccgtgccg ctcgggctgg agtcgctcgc gaacgccgtc      720

gcgcaggagg agtgggggcc gctcttcgcc atgtccaccg tgtcgctcat tccgctcttc      780

ctcatcttct tcttccttca gaagtacgtc gtccgcggca tcgccaccac gggcctgcgc      840

ggctga                                                                 846


<210>   272
<211>   846
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   272
gtgaccggaa ccatccgcac gcggcgcgga atcgtcctcg cgcacgccgt gctcgtgatc       60

atcggattct ttctcatcta tcccgttctc tggatgattt ttggctcatt caagccgacc      120

aacgagatct tctccagcgc ctcgttttgg cccaagcact ggacgttcgc gaattatccg      180

caaggttgga atgcgattcc tggccttccg tttgggacgt tcatcctgca ttcgctgtcg      240

gtgtcatgtc tggtgtctgt cggcacggtc atctcgtccg cgattgtcgc gttcgggttc      300

gcgcgtttca cgttccgagg caaatccatt ctgtttggca tcatgatgat cacgatgatg      360

ctgccgacgc aggtcacgct cattccccag tacgcgatgt ttcacgatct gggctggatc      420

aatacctact atccgctcat tgtgcccgcg ttctttggca gcccgttttt catctttctc      480

atcgttcaat tcatccgggg gttgcccaaa gaattggacg aggccgcgaa gatcgacggc      540

tgcaacgcct tcacgctgtt tgtgcgcgtc atcctgccgc tcatcgtgcc ggcgctcatc      600

accacggcca tcttcagctt catctggtgc tgggatgact tcttctctca gttgatttac      660

cttaattccg cgcagaagtt caccgtgccg ctcgggctgg agtcgctcgc gaacgccgtc      720

gcgcaggagg agtgggggcc gctcttcgcc atgtccaccg tgtcgctcat tccgctcttc      780

ctcatcttct tcttccttca gaagtacgtc gtccgcggca tcgccaccac gggcctgcgc      840

ggctga                                                                 846


<210>   273
<211>   331
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   273
Met Thr Ser Leu Arg Thr Gly Pro Gly Ala Pro Pro Gly His Ser Gly 
                5                   10                  15      

Lys Arg Gly Asp Arg Val Ala Val Ala Thr Thr Thr Lys Ala Asn Val 
            20                  25                  30          

Lys Ala Lys Gly Glu Ala Val Lys Ala Val Arg Pro Arg Asn Glu Lys 
        35                  40                  45              

Val Ala Tyr Leu Phe Leu Ser Pro Trp Met Phe Gly Leu Val Val Phe 
    50                  55                  60                  

Ser Leu Gly Pro Ile Leu Val Ser Leu Tyr Leu Ser Phe Thr Asn Tyr 
65                  70                  75                  80  

Asn Leu Leu Gln Pro Pro Lys Trp Ile Gly Leu Glu Asn Tyr Val His 
                85                  90                  95      

Met Phe Thr Gln Ser Gln Leu Phe Ala Thr Ser Leu Val Asp Thr Leu 
            100                 105                 110         

Glu Tyr Ile Leu Ile Ser Val Pro Ile Lys Met Val Val Ala Leu Ala 
        115                 120                 125             

Ile Ala Leu Leu Leu Ser Leu Glu Val Lys Gly Ile Gly Val Tyr Arg 
    130                 135                 140                 

Thr Val Tyr Tyr Val Pro Ser Leu Ile Gly Thr Ser Val Ala Val Ala 
145                 150                 155                 160 

Tyr Leu Trp Gln Gln Met Phe Gly Pro Asp Gly Leu Ile Asn Lys Gly 
                165                 170                 175     

Leu Ala Leu Val Gly Ile His Gly Pro Asn Trp Leu Ala Glu Pro Arg 
            180                 185                 190         

Thr Ala Leu Phe Thr Leu Ala Met Leu Gln Ala Trp Gln Phe Gly Ser 
        195                 200                 205             

Ala Met Met Ile Phe Val Ala Gly Leu Lys Gln Ile Pro Glu Ser Leu 
    210                 215                 220                 

Tyr Glu Ala Ala Ile Val Asp Gly Ala Gly Arg Leu Tyr Arg Phe Phe 
225                 230                 235                 240 

Arg Ile Thr Ile Pro Met Leu Ser Pro Val Ile Phe Phe Asn Leu Ile 
                245                 250                 255     

Met Ser Ile Ile Asn Gly Phe Thr Gln Phe Thr Gln Gly Tyr Ile Val 
            260                 265                 270         

Thr Asp Gly Gly Pro Leu Asn Ala Thr Leu Phe Phe Ala Leu Tyr Leu 
        275                 280                 285             

Tyr Glu Glu Ala Phe Asn Phe Gln Asn Met Gly Tyr Ala Ser Ala Leu 
    290                 295                 300                 

Ala Trp Phe Leu Leu Val Leu Val Gly Val Leu Thr Phe Leu Val Phe 
305                 310                 315                 320 

Arg Phe Gly Ser Arg Tyr Val Tyr Tyr Glu Ser 
                325                 330     

<210>   274
<211>   996
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   274
gtgacgtctc tgaggacggg gcccggcgca ccgccgggcc attccggaaa gcggggtgat       60

cgcgtggctg tggcaaccac gaccaaggcc aacgtgaagg caaaaggtga ggccgtgaag      120

gccgtgcggc cgcgcaacga gaaggtcgcc tatctgtttc tgagcccatg gatgttcggc      180

ctggtggtgt tttcgctcgg gcccatcctg gtctcgctct atctgtcctt caccaattac      240

aacttattgc agccgccgaa atggattggc ctcgagaatt acgtgcacat gttcacgcag      300

agccagctgt tcgccacttc gctggtggac acgctggagt acatcttgat ctcggtgccc      360

atcaagatgg tggtcgccct cgccatcgcc ctgctcctca gtctcgaggt caaggggatt      420

ggcgtgtatc ggaccgtcta ctacgttccg tcgctcatcg gcacgagcgt cgccgtcgcg      480

tacctgtggc aacaaatgtt tgggcccgac ggtctcatca acaagggtct ggcgctcgtc      540

ggcattcacg ggcccaattg gctcgccgaa ccgcgcacgg ccctgttcac cctggctatg      600

ctgcaggctt ggcagttcgg ttctgcgatg atgatcttcg tggcaggact gaagcagatt      660

cccgagtcgc tgtatgaggc cgccatcgtg gacggcgcgg gccggctgta ccggttcttt      720

cgcatcacca tccccatgtt gtcgccagtc attttcttca acctgatcat gtccatcatc      780

aacgggttca cccagttcac gcagggatac atcgtcacgg acggtgggcc gctgaacgcg      840

acgctgtttt tcgcgctcta cctgtacgag gaggcgttta acttccagaa catgggctac      900

gcgtcggcgc tggcctggtt cctcttggtc ctggtgggcg tgctgacgtt cttggtgttc      960

aggttcggaa gtcgctacgt gtattacgag tcctga                                996


<210>   275
<211>   268
<212>   PRT
<213>   Arthrobacter aurescens TC1

<400>   275
Lys Lys Ala Asn Gly Arg Asp Asn Lys Ala Ala Tyr Ile Phe Leu Leu 
                5                   10                  15      

Pro Trp Leu Val Gly Leu Val Ala Ile Thr Val Gly Pro Met Leu Met 
            20                  25                  30          

Ser Leu Tyr Leu Ser Phe Thr Asp Tyr Asn Leu Leu Gln Pro Pro Glu 
        35                  40                  45              

Trp Val Gly Leu Asp Asn Phe Ile Arg Met Phe Gly Asp Ala Arg Leu 
    50                  55                  60                  

His Asn Ser Leu Arg Val Thr Phe Thr Tyr Val Leu Val Gly Val Pro 
65                  70                  75                  80  

Leu Gln Leu Gly Val Ala Leu Leu Ile Ala Leu Val Leu Asp Lys Gly 
                85                  90                  95      

Leu Arg Gly Leu Pro Phe Tyr Arg Ser Ile Phe Tyr Leu Pro Ser Leu 
            100                 105                 110         

Leu Gly Gly Ser Val Ala Val Ala Ile Leu Trp Lys Gln Ile Phe Gly 
        115                 120                 125             

Thr Thr Gly Leu Val Asn Gln Ile Leu Ala Met Val Gly Ile Glu Gly 
    130                 135                 140                 

Pro Gly Trp Ile Ser Asp Pro Asn Thr Ala Leu Gly Ser Ile Ile Leu 
145                 150                 155                 160 

Leu His Val Trp Thr Phe Gly Ser Pro Met Ile Ile Phe Leu Ala Gly 
                165                 170                 175     

Leu Arg Gln Ile Pro Val Met Tyr Tyr Glu Ala Ala Lys Val Asp Gly 
            180                 185                 190         

Ala Thr Thr Leu Gln Gln Phe Trp Arg Ile Thr Leu Pro Met Leu Ser 
        195                 200                 205             

Pro Ile Ile Phe Phe Asn Leu Val Leu Gln Ile Ile Gly Ser Phe Gln 
    210                 215                 220                 

Ser Phe Thr Gln Ala Phe Ile Val Ser Gly Gly Asn Gly Gly Pro Ser 
225                 230                 235                 240 

Asp Ser Thr Met Phe Phe Thr Leu Tyr Leu Tyr Gln Lys Gly Phe Gly 
                245                 250                 255     

Gln Phe Asp Met Gly Tyr Ala Ser Ala Met Ala Trp 
            260                 265             

<210>   276
<211>   307
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   276
Glu Thr Ile Arg Ala Glu Tyr Pro Pro Asn Arg Lys Thr Ser Ala Lys 
                5                   10                  15      

Trp Arg Val Trp Lys Gln Tyr Leu Val Gly Phe Ala Phe Ile Ser Pro 
            20                  25                  30          

Trp Leu Val Gly Phe Leu Gly Phe Val Ile Gly Pro Met Ile Ala Ser 
        35                  40                  45              

Leu Tyr Tyr Ser Phe Thr Asp Phe Asp Met Leu Thr Ser Pro Asn Trp 
    50                  55                  60                  

Val Gly Leu Asp Asn Tyr Ile Thr Met Phe Thr Asn Asp Pro Arg Phe 
65                  70                  75                  80  

Arg Thr Ser Ile Thr Val Thr Leu Val Phe Val Phe Val Ser Thr Pro 
                85                  90                  95      

Ile Lys Leu Ala Phe Ala Leu Leu Ile Ala Met Leu Phe Asn Asn Lys 
            100                 105                 110         

Arg Lys Gly Ser Gly Phe Tyr Thr Thr Leu Phe Tyr Ile Pro Ser Ile 
        115                 120                 125             

Ile Gly Gly Ser Val Ala Val Ala Val Met Trp Arg Gln Leu Phe Gly 
    130                 135                 140                 

Gly Gln Gly Ala Ile Asn Asp Ile Leu Leu Phe Phe Gly Val Glu Gly 
145                 150                 155                 160 

Lys Ser Trp Ile Ala Ser Pro Asp His Ala Leu Met Val Leu Ile Leu 
                165                 170                 175     

Leu Val Ile Trp Gln Phe Gly Ser Pro Met Ile Ile Phe Leu Ala Gly 
            180                 185                 190         

Leu Arg Gln Ile Pro Glu Asp Leu Tyr Glu Ala Ala Ser Val Asp Gly 
        195                 200                 205             

Ala Gly Lys Phe Arg Lys Phe Leu Ser Ile Thr Ile Pro Leu Leu Thr 
    210                 215                 220                 

Pro Val Ile Phe Phe Asn Leu Ile Met Gln Met Ile Gly Ala Phe Leu 
225                 230                 235                 240 

Val Phe Thr Gln Ala Phe Val Thr Thr Gln Gly Gly Pro Leu Asp Arg 
                245                 250                 255     

Thr Leu Phe Tyr Ala Leu Tyr Leu Tyr Glu Arg Ala Phe Thr Asn Tyr 
            260                 265                 270         

Glu Met Gly Tyr Ala Ser Ala Met Ala Trp Thr Leu Leu Ile Val Ile 
        275                 280                 285             

Ala Ile Val Thr Gly Leu Leu Phe Tyr Ser Ser Lys Lys Trp Val Phe 
    290                 295                 300                 

Tyr Glu Ser 
305         

<210>   277
<211>   263
<212>   PRT
<213>   Kineococcus radiotolerans SRS30216

<400>   277
Arg Gln Gly Arg Ala Ala His Val Phe Leu Ile Pro Trp Leu Leu Gly 
                5                   10                  15      

Leu Val Leu Ile Thr Ala Val Pro Leu Leu Ala Ser Leu Tyr Leu Ala 
            20                  25                  30          

Phe Thr Asp Tyr Asp Leu Leu Asn Ala Pro Thr Trp Thr Gly Leu Glu 
        35                  40                  45              

Asn Phe Arg Arg Met Gly Glu Asp Pro Arg Phe Trp Ala Ser Thr Trp 
    50                  55                  60                  

Val Thr Leu Lys Tyr Val Val Val Ser Val Pro Leu Gln Leu Ala Phe 
65                  70                  75                  80  

Ala Leu Ala Leu Ala Val Val Leu Asp Lys Gly Ile Lys Gly Leu Ala 
                85                  90                  95      

Leu Tyr Arg Ser Val Tyr Tyr Leu Pro Ser Leu Leu Gly Thr Ser Val 
            100                 105                 110         

Ala Val Ala Ile Leu Trp Arg Gln Leu Phe Gly His Asp Gly Leu Ile 
        115                 120                 125             

Asn Ala Gly Leu Ala Leu Leu Gly Val Glu Gly Gln Ser Trp Leu Gln 
    130                 135                 140                 

Asn Pro Ala Thr Ala Leu Ser Thr Ile Val Val Leu Asn Val Trp Thr 
145                 150                 155                 160 

Phe Gly Ser Pro Met Ile Ile Phe Leu Ala Gly Leu Arg Gln Ile Pro 
                165                 170                 175     

Glu Glu Leu Tyr Glu Ala Ala Arg Val Asp Gly Ala Gly Arg Trp Arg 
            180                 185                 190         

Gln Phe Val Ser Ile Thr Ala Pro Met Leu Thr Pro Ile Ile Phe Phe 
        195                 200                 205             

Asn Leu Val Leu Gln Thr Ile Gly Ala Phe Gln Ser Phe Thr Gln Ala 
    210                 215                 220                 

His Val Ile Ser Gly Gly Arg Gly Gly Pro Leu Asp Ser Thr Leu Phe 
225                 230                 235                 240 

Tyr Thr Leu Tyr Leu Tyr Gln Gln Gly Phe Val Asn Phe Asn Met Gly 
                245                 250                 255     

Tyr Ala Ser Ala Met Ala Trp 
            260             

<210>   278
<211>   268
<212>   PRT
<213>   Arthrobacter sp. FB24

<400>   278
Lys Lys Ala Asn Gly Arg Asp Asn Lys Ala Ala Tyr Ile Phe Leu Leu 
                5                   10                  15      

Pro Trp Leu Val Gly Leu Val Ala Ile Thr Ile Gly Pro Met Leu Met 
            20                  25                  30          

Ser Leu Tyr Leu Ser Phe Thr Asp Tyr Asn Leu Leu Gln Pro Pro Glu 
        35                  40                  45              

Trp Thr Gly Leu Asp Asn Phe Thr Arg Met Leu Ser Asp Ala Arg Leu 
    50                  55                  60                  

His Asn Ser Leu Arg Val Thr Phe Thr Tyr Val Phe Val Gly Val Pro 
65                  70                  75                  80  

Leu Gln Leu Ala Val Ala Leu Leu Ile Ala Leu Val Leu Asp Lys Gly 
                85                  90                  95      

Leu Arg Gly Leu Pro Phe Tyr Arg Ser Val Phe Tyr Leu Pro Ser Leu 
            100                 105                 110         

Leu Gly Gly Ser Val Ala Val Ala Ile Leu Trp Lys Gln Ile Phe Gly 
        115                 120                 125             

Thr Thr Gly Leu Val Asn Gln Val Leu Ala Met Phe Gly Val Gln Gly 
    130                 135                 140                 

Pro Gly Trp Ile Ser Asp Pro Ser Thr Ala Leu Gly Ser Ile Ile Leu 
145                 150                 155                 160 

Leu His Val Trp Thr Phe Gly Ala Pro Met Ile Ile Phe Leu Ala Gly 
                165                 170                 175     

Leu Arg Gln Ile Pro Val Met Tyr Tyr Glu Ala Ala Lys Val Asp Gly 
            180                 185                 190         

Ala Ser Thr Leu Gln Gln Phe Arg Arg Ile Thr Met Pro Met Leu Ser 
        195                 200                 205             

Pro Ile Ile Phe Phe Asn Leu Val Leu Gln Ile Ile Gly Ser Phe Gln 
    210                 215                 220                 

Ser Phe Thr Gln Ala Phe Ile Val Ser Gly Gly Asn Gly Gly Pro Ser 
225                 230                 235                 240 

Asp Ser Thr Met Phe Phe Thr Leu Tyr Leu Tyr Gln Lys Gly Phe Gly 
                245                 250                 255     

Gln Phe Asp Met Gly Tyr Ala Ser Ala Met Ala Trp 
            260                 265             

<210>   279
<211>   283
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   279
Val Gly Tyr Phe Phe Leu Thr Pro Trp Leu Ile Gly Leu Ile Gly Leu 
                5                   10                  15      

Ser Val Ile Pro Met Ala Ala Ser Leu Tyr Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          

Asp Met Phe Thr Ala Pro Glu Trp Ile Gly Leu Ser Asn Tyr Ile Glu 
        35                  40                  45              

Met Phe Asn Asp Ala Lys Trp Leu Lys Ser Val Lys Val Thr Leu Ile 
    50                  55                  60                  

Tyr Val Phe Leu Gly Val Pro Leu Gln Leu Ala Phe Ala Leu Gly Val 
65                  70                  75                  80  

Ala Val Leu Leu Asn Arg Gly Leu Lys Gly Leu Gln Val Tyr Arg Ala 
                85                  90                  95      

Ile Tyr Tyr Val Pro Ser Leu Phe Gly Gly Ser Val Ala Ile Ala Leu 
            100                 105                 110         

Leu Trp Arg Gln Leu Phe Gly Gly Glu Gly Leu Ile Asn Lys Val Leu 
        115                 120                 125             

Ala Leu Val Gly Ile Glu Gly Gln Asn Trp Ile Ser Ser Pro Asp Thr 
    130                 135                 140                 

Ala Leu Tyr Thr Leu Ile Ile Leu Thr Ile Trp Gln Phe Gly Ala Pro 
145                 150                 155                 160 

Met Val Ile Phe Leu Ala Gly Leu Lys Gln Val Pro Val Glu Leu Tyr 
                165                 170                 175     

Glu Ser Ser Leu Ile Asp Gly Ala Gly Pro Val Lys Gln Phe Phe Ser 
            180                 185                 190         

Ile Thr Leu Pro Leu Ile Thr Pro Ile Ile Phe Phe Asn Leu Val Met 
        195                 200                 205             

Gln Ile Ile Ser Ala Phe Gln Ala Phe Thr Pro Ala Tyr Ile Val Ser 
    210                 215                 220                 

Gly Gly Lys Gly Gly Pro Leu Asp Ser Thr Leu Phe Tyr Thr Leu Tyr 
225                 230                 235                 240 

Leu Tyr Gln Lys Gly Phe Thr Gln Phe Gln Met Gly Tyr Ala Ser Ala 
                245                 250                 255     

Met Ala Trp Phe Leu Leu Ala Cys Ile Ser Val Val Thr Ala Ile Val 
            260                 265                 270         

Phe Ile Ser Ser Lys Lys Trp Val Tyr Tyr Gln 
        275                 280             

<210>   280
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   280
Met Thr Ser Leu Arg Thr Gly Pro Gly Ala Pro Pro Gly His Ser Gly 
                5                   10                  15      

Lys Arg Gly Asp Arg Val Ala Val Ala Thr Thr Thr Lys Ala Asn Ile 
            20                  25                  30          

Lys Ala Lys Gly Glu Ala Val Lys Ala Val Arg Pro Arg Asn Glu Lys 
        35                  40                  45              

Val Ala Tyr Leu Phe Leu Ser Pro Trp Met Phe Gly Leu Val Val Phe 
    50                  55                  60                  

Ser Leu Gly Pro Ile Leu Val Ser Leu Tyr Leu Ser Phe Thr Asn Tyr 
65                  70                  75                  80  

Asn Leu Leu Gln Pro Pro Lys Trp Ile Gly Leu Glu Asn Tyr Val His 
                85                  90                  95      

Met Phe Thr Gln Ser Gln Leu Phe Ala Thr Ser Leu Val Asp Thr Leu 
            100                 105                 110         

Glu Tyr Ile Leu Ile Ser Val Pro Ile Lys Met Val Val Ala Leu Ala 
        115                 120                 125             

Ile Ala Leu Leu Leu Ser Leu Glu Val Lys Gly Ile Gly Val Tyr Arg 
    130                 135                 140                 

Thr Val Tyr Tyr Val Pro Ser Leu Ile Gly Thr Ser Val Ala Val Ala 
145                 150                 155                 160 

Tyr Leu Trp Gln Gln Met Phe Gly Pro Asp Gly Leu Ile Asn Lys Gly 
                165                 170                 175     

Leu Ala Leu Val Gly Ile His Gly Pro Asn Trp Leu Ala Glu Pro Arg 
            180                 185                 190         

Thr Ala Leu Phe Thr Leu Ala Met Leu Gln Ala Trp Gln Phe Gly Ser 
        195                 200                 205             

Ala Met Met Ile Phe Val Ala Gly Leu Lys Gln Ile Pro Glu Ser Leu 
    210                 215                 220                 

Tyr Glu Ala Ala Ile Val Asp Gly Ala Gly Arg Leu Tyr Arg Phe Phe 
225                 230                 235                 240 

Arg Ile Thr Ile Pro Met Leu Ser Pro Val Ile Phe Phe Asn Leu Ile 
                245                 250                 255     

Met Ser Ile Ile Asn Gly Phe Thr Gln Phe Thr Gln Gly Tyr Ile Val 
            260                 265                 270         

Thr Asp Gly Gly Pro Leu Asn Ala Thr Leu Phe Phe Ala Leu Tyr Leu 
        275                 280                 285             

Tyr Glu Glu Ala Phe Asn Phe Gln Asn Met Gly Tyr Ala Ser Ala Leu 
    290                 295                 300                 

Ala Trp Phe Leu Leu Val Leu Val Gly Val Leu Thr Phe Leu Val Phe 
305                 310                 315                 320 

Arg Phe Gly Ser Arg Tyr Val Tyr Tyr Glu Ser 
                325                 330     

<210>   281
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   281
Met Thr Ser Leu Arg Thr Gly Pro Gly Ala Pro Pro Gly His Ser Gly 
                5                   10                  15      

Lys Arg Gly Asp Arg Val Ala Val Ala Thr Thr Thr Lys Ala Asn Val 
            20                  25                  30          

Lys Ala Lys Gly Glu Ala Val Lys Ala Val Arg Pro Arg Asn Glu Lys 
        35                  40                  45              

Val Ala Tyr Leu Phe Leu Ser Pro Trp Met Phe Gly Leu Val Val Phe 
    50                  55                  60                  

Ser Leu Gly Pro Ile Leu Val Ser Leu Tyr Leu Ser Phe Thr Asn Tyr 
65                  70                  75                  80  

Asn Leu Leu Gln Pro Pro Lys Trp Ile Gly Leu Glu Asn Tyr Val His 
                85                  90                  95      

Met Phe Thr Gln Ser Gln Leu Phe Ala Thr Ser Leu Val Asp Thr Leu 
            100                 105                 110         

Glu Tyr Ile Leu Ile Ser Val Pro Ile Lys Met Val Val Ala Leu Ala 
        115                 120                 125             

Ile Ala Leu Leu Leu Ser Leu Glu Val Lys Gly Ile Gly Val Tyr Arg 
    130                 135                 140                 

Thr Val Tyr Tyr Val Pro Ser Leu Ile Gly Thr Ser Val Ala Val Ala 
145                 150                 155                 160 

Tyr Leu Trp Gln Gln Met Phe Gly Pro Asp Gly Leu Ile Asn Lys Gly 
                165                 170                 175     

Leu Ala Leu Val Gly Ile His Gly Pro Asn Trp Leu Ala Glu Pro Arg 
            180                 185                 190         

Thr Ala Leu Phe Thr Leu Ala Met Leu Gln Ala Trp Gln Phe Gly Ser 
        195                 200                 205             

Ala Met Met Ile Phe Val Ala Gly Leu Arg Gln Ile Pro Glu Ser Leu 
    210                 215                 220                 

Tyr Glu Ala Ala Ile Val Asp Gly Ala Gly Arg Leu Tyr Arg Phe Phe 
225                 230                 235                 240 

Arg Ile Thr Ile Pro Met Leu Ser Pro Val Ile Phe Phe Asn Leu Ile 
                245                 250                 255     

Met Ser Ile Ile Asn Gly Phe Thr Gln Phe Thr Gln Gly Tyr Ile Val 
            260                 265                 270         

Thr Asp Gly Gly Pro Leu Asn Ala Thr Leu Phe Phe Ala Leu Tyr Leu 
        275                 280                 285             

Tyr Glu Glu Ala Phe Asn Phe Gln Asn Met Gly Tyr Ala Ser Ala Leu 
    290                 295                 300                 

Ala Trp Phe Leu Leu Val Leu Val Gly Val Leu Thr Phe Leu Val Phe 
305                 310                 315                 320 

Arg Phe Gly Ser Arg Tyr Val Tyr Tyr Glu Ser 
                325                 330     

<210>   282
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   282
Met Thr Ser Leu Arg Thr Gly Pro Gly Ala Pro Pro Gly His Ser Gly 
                5                   10                  15      

Lys Arg Gly Asp Arg Val Ala Val Ala Thr Thr Thr Lys Ala Asn Val 
            20                  25                  30          

Lys Ala Lys Gly Glu Ala Val Lys Ala Val Arg Pro Arg Asn Glu Lys 
        35                  40                  45              

Val Ala Tyr Leu Phe Leu Ser Pro Trp Met Phe Gly Leu Val Val Phe 
    50                  55                  60                  

Ser Leu Gly Pro Ile Leu Val Ser Leu Tyr Leu Ser Phe Thr Asn Tyr 
65                  70                  75                  80  

Asn Leu Leu Gln Pro Pro Lys Trp Ile Gly Leu Glu Asn Tyr Val His 
                85                  90                  95      

Met Phe Thr Gln Ser Gln Leu Phe Ala Thr Ser Leu Val Asp Thr Leu 
            100                 105                 110         

Glu Tyr Ile Leu Ile Ser Val Pro Ile Lys Met Val Val Ala Leu Ala 
        115                 120                 125             

Ile Ala Leu Leu Leu Ser Leu Glu Val Lys Gly Ile Gly Val Tyr Arg 
    130                 135                 140                 

Thr Val Tyr Tyr Val Pro Ser Leu Ile Gly Thr Ser Val Ala Val Ala 
145                 150                 155                 160 

Tyr Leu Trp Gln Gln Met Phe Gly Pro Asp Gly Leu Ile Asn Lys Gly 
                165                 170                 175     

Leu Ala Leu Val Gly Ile His Gly Pro Asn Trp Leu Ala Glu Pro Arg 
            180                 185                 190         

Thr Ala Leu Phe Thr Leu Ala Met Leu Gln Ala Trp Gln Phe Gly Ser 
        195                 200                 205             

Ala Met Met Ile Phe Val Ala Gly Leu Lys Gln Ile Pro Glu Ser Leu 
    210                 215                 220                 

Tyr Glu Ala Ala Ile Val Asp Gly Ala Gly Arg Leu Tyr Arg Phe Phe 
225                 230                 235                 240 

Arg Ile Thr Ile Pro Met Leu Ser Pro Val Ile Phe Phe Asn Leu Ile 
                245                 250                 255     

Met Ser Ile Ile Asn Gly Phe Thr Gln Phe Thr Gln Gly Tyr Ile Val 
            260                 265                 270         

Thr Asp Gly Gly Pro Leu Asn Ala Thr Leu Phe Phe Ala Leu Tyr Leu 
        275                 280                 285             

Tyr Glu Glu Ala Phe Asn Phe Gln Asn Met Gly Tyr Ala Ser Ala Leu 
    290                 295                 300                 

Ala Trp Phe Leu Leu Val Leu Val Gly Val Leu Thr Phe Leu Val Phe 
305                 310                 315                 320 

Arg Phe Gly Ser Arg Tyr Ile Tyr Tyr Glu Ser 
                325                 330     

<210>   283
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   283
Met Thr Ser Leu Arg Thr Gly Pro Gly Ala Pro Pro Gly His Ser Gly 
                5                   10                  15      

Lys Arg Gly Asp Arg Val Ala Val Ala Thr Thr Thr Lys Ala Asn Val 
            20                  25                  30          

Lys Ala Lys Gly Glu Ala Val Lys Ala Val Arg Pro Arg Asn Glu Lys 
        35                  40                  45              

Val Ala Tyr Leu Phe Leu Ser Pro Trp Met Phe Gly Leu Val Val Phe 
    50                  55                  60                  

Ser Leu Gly Pro Ile Leu Val Ser Leu Tyr Leu Ser Phe Thr Asn Tyr 
65                  70                  75                  80  

Asn Leu Leu Gln Pro Pro Lys Trp Ile Gly Leu Glu Asn Tyr Val His 
                85                  90                  95      

Met Phe Thr Gln Ser Gln Leu Phe Ala Thr Ser Leu Val Asp Thr Leu 
            100                 105                 110         

Glu Tyr Ile Leu Ile Ser Val Pro Ile Lys Met Val Val Ala Leu Ala 
        115                 120                 125             

Ile Ala Leu Leu Leu Ser Leu Glu Val Lys Gly Ile Gly Val Tyr Arg 
    130                 135                 140                 

Thr Val Tyr Tyr Val Pro Ser Leu Ile Gly Thr Ser Val Ala Val Ala 
145                 150                 155                 160 

Tyr Leu Trp Gln Gln Met Phe Gly Pro Asp Gly Leu Ile Asn Lys Gly 
                165                 170                 175     

Leu Ala Leu Val Gly Ile His Gly Pro Asn Trp Leu Ala Glu Pro Arg 
            180                 185                 190         

Thr Ala Leu Phe Thr Leu Ala Met Leu Gln Ala Trp Gln Phe Gly Ser 
        195                 200                 205             

Ala Met Met Ile Phe Val Ala Gly Leu Lys Gln Ile Pro Glu Ser Leu 
    210                 215                 220                 

Tyr Glu Ala Ala Ile Val Asp Gly Ala Gly Arg Leu Tyr Arg Phe Phe 
225                 230                 235                 240 

Arg Ile Thr Ile Pro Met Leu Ser Pro Val Ile Phe Phe Asn Leu Ile 
                245                 250                 255     

Met Ser Ile Ile Asn Gly Phe Thr Gln Phe Thr Gln Gly Tyr Ile Val 
            260                 265                 270         

Thr Asp Gly Gly Pro Leu Asn Ala Thr Leu Phe Phe Ala Leu Tyr Leu 
        275                 280                 285             

Tyr Glu Glu Ala Phe Asn Phe Gln Asn Met Gly Tyr Ala Ser Ala Leu 
    290                 295                 300                 

Ala Trp Phe Leu Leu Val Leu Val Gly Val Leu Thr Phe Leu Ile Phe 
305                 310                 315                 320 

Arg Phe Gly Ser Arg Tyr Val Tyr Tyr Glu Ser 
                325                 330     

<210>   284
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   284
Met Thr Ser Leu Arg Thr Gly Pro Gly Ala Pro Pro Gly His Ser Gly 
                5                   10                  15      

Lys Arg Gly Asp Arg Val Ala Val Ala Thr Thr Thr Lys Ala Asn Val 
            20                  25                  30          

Lys Ala Lys Gly Glu Ala Val Lys Ala Val Arg Pro Arg Asn Glu Lys 
        35                  40                  45              

Val Ala Tyr Leu Phe Leu Ser Pro Trp Met Phe Gly Leu Val Val Phe 
    50                  55                  60                  

Ser Leu Gly Pro Ile Leu Val Ser Leu Tyr Leu Ser Phe Thr Asn Tyr 
65                  70                  75                  80  

Asn Leu Leu Gln Pro Pro Lys Trp Ile Gly Leu Glu Asn Tyr Val His 
                85                  90                  95      

Met Phe Thr Gln Ser Gln Leu Phe Ala Thr Ser Leu Val Asp Thr Leu 
            100                 105                 110         

Glu Tyr Ile Leu Ile Ser Ile Pro Ile Lys Met Val Val Ala Leu Ala 
        115                 120                 125             

Ile Ala Leu Leu Leu Ser Leu Glu Val Lys Gly Ile Gly Val Tyr Arg 
    130                 135                 140                 

Thr Val Tyr Tyr Val Pro Ser Leu Ile Gly Thr Ser Val Ala Val Ala 
145                 150                 155                 160 

Tyr Leu Trp Gln Gln Met Phe Gly Pro Asp Gly Leu Ile Asn Lys Gly 
                165                 170                 175     

Leu Ala Leu Val Gly Ile His Gly Pro Asn Trp Leu Ala Glu Pro Arg 
            180                 185                 190         

Thr Ala Leu Phe Thr Leu Ala Met Leu Gln Ala Trp Gln Phe Gly Ser 
        195                 200                 205             

Ala Met Met Ile Phe Val Ala Gly Leu Lys Gln Ile Pro Glu Ser Leu 
    210                 215                 220                 

Tyr Glu Ala Ala Ile Val Asp Gly Ala Gly Arg Leu Tyr Arg Phe Phe 
225                 230                 235                 240 

Arg Ile Thr Ile Pro Met Leu Ser Pro Val Ile Phe Phe Asn Leu Ile 
                245                 250                 255     

Met Ser Ile Ile Asn Gly Phe Thr Gln Phe Thr Gln Gly Tyr Ile Val 
            260                 265                 270         

Thr Asp Gly Gly Pro Leu Asn Ala Thr Leu Phe Phe Ala Leu Tyr Leu 
        275                 280                 285             

Tyr Glu Glu Ala Phe Asn Phe Gln Asn Met Gly Tyr Ala Ser Ala Leu 
    290                 295                 300                 

Ala Trp Phe Leu Leu Val Leu Val Gly Val Leu Thr Phe Leu Val Phe 
305                 310                 315                 320 

Arg Phe Gly Ser Arg Tyr Val Tyr Tyr Glu Ser 
                325                 330     

<210>   285
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   285
gtgacgtctc tgaggacggg gcccggcgca ccgccgggcc attccggaaa gcggggtgat       60

cgcgtggctg tggcaaccac gaccaaggcc aacattaagg caaaaggtga ggccgtgaag      120

gccgtgcggc cgcgcaacga gaaggtcgcc tatctgtttc tgagcccatg gatgttcggc      180

ctggtggtgt tttcgctcgg gcccatcctg gtctcgctct atctgtcctt caccaattac      240

aacttattgc agccgccgaa atggattggc ctcgagaatt acgtgcacat gttcacgcag      300

agccagctgt tcgccacttc gctggtggac acgctggagt acatcttgat ctcggtgccc      360

atcaagatgg tggtcgccct cgccatcgcc ctgctcctca gtctcgaggt caaggggatt      420

ggcgtgtatc ggaccgtcta ctacgttccg tcgctcatcg gcacgagcgt cgccgtcgcg      480

tacctgtggc aacaaatgtt tgggcccgac ggtctcatca acaagggtct ggcgctcgtc      540

ggcattcacg ggcccaattg gctcgccgaa ccgcgcacgg ccctgttcac cctggctatg      600

ctgcaggctt ggcagttcgg ttctgcgatg atgatcttcg tggcaggact gaagcagatt      660

cccgagtcgc tgtatgaggc cgccatcgtg gacggcgcgg gccggctgta ccggttcttt      720

cgcatcacca tccccatgtt gtcgccagtc attttcttca acctgatcat gtccatcatc      780

aacgggttca cccagttcac gcagggatac atcgtcacgg acggtgggcc gctgaacgcg      840

acgctgtttt tcgcgctcta cctgtacgag gaggcgttta acttccagaa catgggctac      900

gcgtcggcgc tggcctggtt cctcttggtc ctggtgggcg tgctgacgtt cttggtgttc      960

aggttcggaa gtcgctacgt gtattacgag tcctga                                996


<210>   286
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   286
gtgacgtctc tgaggacggg gcccggcgca ccgccgggcc attccggaaa gcggggtgat       60

cgcgtggctg tggcaaccac gaccaaggcc aacgtgaagg caaaaggtga ggccgtgaag      120

gccgtgcggc cgcgcaacga gaaggtcgcc tatctgtttc tgagcccatg gatgttcggc      180

ctggtggtgt tttcgctcgg gcccatcctg gtctcgctct atctgtcctt caccaattac      240

aacttattgc agccgccgaa atggattggc ctcgagaatt acgtgcacat gttcacgcag      300

agccagctgt tcgccacttc gctggtggac acgctggagt acatcttgat ctcggtgccc      360

atcaagatgg tggtcgccct cgccatcgcc ctgctcctca gtctcgaggt caaggggatt      420

ggcgtgtatc ggaccgtcta ctacgttccg tcgctcatcg gcacgagcgt cgccgtcgcg      480

tacctgtggc aacaaatgtt tgggcccgac ggtctcatca acaagggtct ggcgctcgtc      540

ggcattcacg ggcccaattg gctcgccgaa ccgcgcacgg ccctgttcac cctggctatg      600

ctgcaggctt ggcagttcgg ttctgcgatg atgatcttcg tggcaggact gcgtcagatt      660

cccgagtcgc tgtatgaggc cgccatcgtg gacggcgcgg gccggctgta ccggttcttt      720

cgcatcacca tccccatgtt gtcgccagtc attttcttca acctgatcat gtccatcatc      780

aacgggttca cccagttcac gcagggatac atcgtcacgg acggtgggcc gctgaacgcg      840

acgctgtttt tcgcgctcta cctgtacgag gaggcgttta acttccagaa catgggctac      900

gcgtcggcgc tggcctggtt cctcttggtc ctggtgggcg tgctgacgtt cttggtgttc      960

aggttcggaa gtcgctacgt gtattacgag tcctga                                996


<210>   287
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   287
gtgacgtctc tgaggacggg gcccggcgca ccgccgggcc attccggaaa gcggggtgat       60

cgcgtggctg tggcaaccac gaccaaggcc aacgtgaagg caaaaggtga ggccgtgaag      120

gccgtgcggc cgcgcaacga gaaggtcgcc tatctgtttc tgagcccatg gatgttcggc      180

ctggtggtgt tttcgctcgg gcccatcctg gtctcgctct atctgtcctt caccaattac      240

aacttattgc agccgccgaa atggattggc ctcgagaatt acgtgcacat gttcacgcag      300

agccagctgt tcgccacttc gctggtggac acgctggagt acatcttgat ctcggtgccc      360

atcaagatgg tggtcgccct cgccatcgcc ctgctcctca gtctcgaggt caaggggatt      420

ggcgtgtatc ggaccgtcta ctacgttccg tcgctcatcg gcacgagcgt cgccgtcgcg      480

tacctgtggc aacaaatgtt tgggcccgac ggtctcatca acaagggtct ggcgctcgtc      540

ggcattcacg ggcccaattg gctcgccgaa ccgcgcacgg ccctgttcac cctggctatg      600

ctgcaggctt ggcagttcgg ttctgcgatg atgatcttcg tggcaggact gaagcagatt      660

cccgagtcgc tgtatgaggc cgccatcgtg gacggcgcgg gccggctgta ccggttcttt      720

cgcatcacca tccccatgtt gtcgccagtc attttcttca acctgatcat gtccatcatc      780

aacgggttca cccagttcac gcagggatac atcgtcacgg acggtgggcc gctgaacgcg      840

acgctgtttt tcgcgctcta cctgtacgag gaggcgttta acttccagaa catgggctac      900

gcgtcggcgc tggcctggtt cctcttggtc ctggtgggcg tgctgacgtt cttggtgttc      960

aggttcggaa gtcgctacat ttattacgag tcctga                                996


<210>   288
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   288
gtgacgtctc tgaggacggg gcccggcgca ccgccgggcc attccggaaa gcggggtgat       60

cgcgtggctg tggcaaccac gaccaaggcc aacgtgaagg caaaaggtga ggccgtgaag      120

gccgtgcggc cgcgcaacga gaaggtcgcc tatctgtttc tgagcccatg gatgttcggc      180

ctggtggtgt tttcgctcgg gcccatcctg gtctcgctct atctgtcctt caccaattac      240

aacttattgc agccgccgaa atggattggc ctcgagaatt acgtgcacat gttcacgcag      300

agccagctgt tcgccacttc gctggtggac acgctggagt acatcttgat ctcggtgccc      360

atcaagatgg tggtcgccct cgccatcgcc ctgctcctca gtctcgaggt caaggggatt      420

ggcgtgtatc ggaccgtcta ctacgttccg tcgctcatcg gcacgagcgt cgccgtcgcg      480

tacctgtggc aacaaatgtt tgggcccgac ggtctcatca acaagggtct ggcgctcgtc      540

ggcattcacg ggcccaattg gctcgccgaa ccgcgcacgg ccctgttcac cctggctatg      600

ctgcaggctt ggcagttcgg ttctgcgatg atgatcttcg tggcaggact gaagcagatt      660

cccgagtcgc tgtatgaggc cgccatcgtg gacggcgcgg gccggctgta ccggttcttt      720

cgcatcacca tccccatgtt gtcgccagtc attttcttca acctgatcat gtccatcatc      780

aacgggttca cccagttcac gcagggatac atcgtcacgg acggtgggcc gctgaacgcg      840

acgctgtttt tcgcgctcta cctgtacgag gaggcgttta acttccagaa catgggctac      900

gcgtcggcgc tggcctggtt cctcttggtc ctggtgggcg tgctgacgtt cttgattttc      960

aggttcggaa gtcgctacgt gtattacgag tcctga                                996


<210>   289
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   289
gtgacgtctc tgaggacggg gcccggcgca ccgccgggcc attccggaaa gcggggtgat       60

cgcgtggctg tggcaaccac gaccaaggcc aacgtgaagg caaaaggtga ggccgtgaag      120

gccgtgcggc cgcgcaacga gaaggtcgcc tatctgtttc tgagcccatg gatgttcggc      180

ctggtggtgt tttcgctcgg gcccatcctg gtctcgctct atctgtcctt caccaattac      240

aacttattgc agccgccgaa atggattggc ctcgagaatt acgtgcacat gttcacgcag      300

agccagctgt tcgccacttc gctggtggac acgctggagt acatcttgat ctcgattccc      360

atcaagatgg tggtcgccct cgccatcgcc ctgctcctca gtctcgaggt caaggggatt      420

ggcgtgtatc ggaccgtcta ctacgttccg tcgctcatcg gcacgagcgt cgccgtcgcg      480

tacctgtggc aacaaatgtt tgggcccgac ggtctcatca acaagggtct ggcgctcgtc      540

ggcattcacg ggcccaattg gctcgccgaa ccgcgcacgg ccctgttcac cctggctatg      600

ctgcaggctt ggcagttcgg ttctgcgatg atgatcttcg tggcaggact gaagcagatt      660

cccgagtcgc tgtatgaggc cgccatcgtg gacggcgcgg gccggctgta ccggttcttt      720

cgcatcacca tccccatgtt gtcgccagtc attttcttca acctgatcat gtccatcatc      780

aacgggttca cccagttcac gcagggatac atcgtcacgg acggtgggcc gctgaacgcg      840

acgctgtttt tcgcgctcta cctgtacgag gaggcgttta acttccagaa catgggctac      900

gcgtcggcgc tggcctggtt cctcttggtc ctggtgggcg tgctgacgtt cttggtgttc      960

aggttcggaa gtcgctacgt gtattacgag tcctga                                996


<210>   290
<211>   448
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   290
Met Lys Arg Gly Gly Ile Arg Met Arg Lys Lys Arg Trp Thr Trp Thr 
                5                   10                  15      

Ala Ser Ala Ala Ala Ala Leu Val Leu Ala Gly Cys Gly Thr Ala Ala 
            20                  25                  30          

Ala Gln Gly Gly Ser Ser Gly Ser Gln Ala Gly Gln Ala Ala Gly Ser 
        35                  40                  45              

Ala Asp Ser Lys Pro Val Val Thr Leu Thr Phe Gly Phe Trp Gly Asp 
    50                  55                  60                  

Ala Lys Glu Glu Ala Val Thr Leu Ala Ala Val Lys Ala Phe Glu Lys 
65                  70                  75                  80  

Ala Tyr Pro Asn Ile His Ile Gln Thr Glu Phe Gly Gly Pro Phe Asn 
                85                  90                  95      

Gln Tyr Phe Thr Lys Leu Ser Thr Glu Val Ala Gly Gly Asn Ala Pro 
            100                 105                 110         

Asp Ile Met Gln Met Asp Tyr Glu Tyr Ile Asp Ala Tyr Ala Lys Glu 
        115                 120                 125             

Gly Gln Leu Leu Asn Leu Lys Gly Ala Lys Gly Ile Asn Ile Ser Thr 
    130                 135                 140                 

Ile Ser Pro Ser Val Leu Lys Ser Gly Tyr Ile Asp Gly Gly Leu Tyr 
145                 150                 155                 160 

Gly Ile Pro Asn Ala Leu Asn Asn Tyr Ala Val Ile Tyr Asp Glu Ala 
                165                 170                 175     

Ala Phe Ala Lys Ala Gly Tyr His Gly Gln Arg Val Ser Trp Gln Gln 
            180                 185                 190         

Trp Ala Asp Ile Leu Glu Lys Val His Lys Ala Thr Gly Lys Trp Ala 
        195                 200                 205             

Glu Asn Asp Asp Glu Ser Trp Gln Thr Phe Gly Tyr Trp Ala Arg Gln 
    210                 215                 220                 

His Gly Gln His Leu Tyr Asn Ala Ser Gly Thr Lys Leu Gly Phe Thr 
225                 230                 235                 240 

Glu Ser Thr Leu Val Ser Tyr Leu Asn Tyr Trp Ala Asn Leu Arg Lys 
                245                 250                 255     

Glu Gly Val Val Pro Pro Gly Thr Val Thr Ser Leu Ile Lys Gln Thr 
            260                 265                 270         

Ala Asp Pro Thr Asp Pro Met Val Gln Gly Lys Ser Asp Ala Glu Leu 
        275                 280                 285             

Thr Trp Val Asn Tyr Val Val Ser Leu Gln Ser Glu Met Thr Arg Ser 
    290                 295                 300                 

Leu Ala Leu Ala Leu Pro Pro Thr Gln Pro Gly Gly Glu Glu Gly Leu 
305                 310                 315                 320 

Tyr Ile Lys Pro Ser Gln Phe Trp Ser Ile Tyr Ser Lys Thr Lys Tyr 
                325                 330                 335     

Pro Gln Gln Ala Glu Leu Phe Val Asn Phe Leu Leu Asn Asn Val Gln 
            340                 345                 350         

Ala Gly Lys Ala Leu Gly Leu Val Arg Gly Ile Pro Val Ser Ser Ser 
        355                 360                 365             

Val Arg Thr Gln Leu Met Ala Ser Gly Thr Ser Ala Pro Glu Lys Ala 
    370                 375                 380                 

Glu Phe Gln Leu Val Asn Glu Ala Leu Lys Val Ala Thr Pro Ile Asp 
385                 390                 395                 400 

Pro Pro Pro Pro Gln His Asp Lys Glu Ile Asp Gln Asp Phe Ala Asn 
                405                 410                 415     

Met Val Gln Ala Val Gln Tyr Gly Lys Glu Thr Pro Gln Gln Gly Ala 
            420                 425                 430         

Glu Gln Phe Met Gln Glu Ala Asn Asp Leu Leu Gln Asn Gly Gly Glu 
        435                 440                 445             

<210>   291
<211>   1347
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   291
gtgaaacgag gaggaatccg catgcgaaaa aagagatgga catggacggc gagcgccgcg       60

gctgcgctgg tgttggcggg ctgcggcacc gcggcggcgc agggcggttc gagtgggtcg      120

caagccgggc aggccgcggg aagcgcggac tcgaagccgg tggtcacgct caccttcggc      180

ttctggggcg atgcgaagga agaggcggtc acgctggccg cggtgaaagc gtttgagaag      240

gcgtatccga acattcacat ccagaccgaa ttcggagggc cattcaatca gtacttcacg      300

aagctgtcca ccgaggtcgc gggcggcaac gcaccagaca tcatgcagat ggattacgaa      360

tacattgacg cctacgccaa ggaaggccag ttgctcaacc tgaagggcgc gaagggaatc      420

aacatctcca ccatcagccc gagcgtcctg aagagcggct acatcgacgg cgggttgtat      480

ggcattccga atgcgctgaa taactatgcg gtcatctacg acgaggccgc gtttgccaag      540

gcgggctatc acggccaacg cgtttcatgg caacagtggg cggatatcct cgaaaaggtc      600

cataaggcga caggcaagtg ggccgagaac gacgacgaga gctggcagac ctttggatac      660

tgggcgcgcc agcacggtca gcacctatac aacgcctccg ggacgaagct cggatttacc      720

gagagcacgc tcgtctccta tctgaactac tgggcgaatc ttcgcaaaga gggcgttgtg      780

ccgcccggga ccgtgacatc cctcatcaag cagacggccg atccgacgga tccgatggtg      840

caagggaaat cggatgcgga actcacctgg gtcaactacg tcgtcagcct gcagagcgag      900

atgacgcgaa gcttggcgct ggcccttccg ccgacacagc cgggtggaga ggagggcctg      960

tatatcaagc cgagccagtt ctggagcatc tattccaaga cgaagtatcc gcagcaagcc     1020

gagctctttg tcaacttctt gctgaacaac gtccaagcgg gcaaggcgct cgggctcgtg     1080

cgcggcatcc cggtgtcgtc ctccgtccgc actcagttga tggcatccgg cacctcggcg     1140

cctgaaaagg ccgagttcca gctggtgaac gaggcgctca aggtggccac gcccatcgat     1200

cctccgccgc cgcagcacga caaggagatc gaccaggact tcgcgaacat ggtccaggct     1260

gtgcaatacg gcaaggaaac gccccagcag ggcgccgaac agtttatgca ggaggcgaac     1320

gatctcctgc agaacggcgg cgagtga                                         1347


<210>   292
<211>   392
<212>   PRT
<213>   Thermobifida fusca YX

<400>   292
Val Val Glu Leu Arg Phe Ser Trp Trp Gly Ser Asp Glu Arg His Ala 
                5                   10                  15      

Met Thr Gln Glu Val Ile Glu Leu Phe Glu Glu Gln Asn Pro Gly Ile 
            20                  25                  30          

Lys Ile Val Gly Glu Tyr Thr Asp Trp Ala Ser Tyr Trp Asp Lys Leu 
        35                  40                  45              

Ala Thr Thr Thr Ala Ala Gly Asp Ala Pro Asp Ile Ile Thr Gln Glu 
    50                  55                  60                  

Glu Arg Tyr Leu Arg Glu Tyr Ala Glu Arg Gly Ala Leu Leu Asp Leu 
65                  70                  75                  80  

Ser Gln Leu Asp Gly Leu Asp Leu Ser Lys Ile Asp Pro Leu Val Ala 
                85                  90                  95      

Glu Ser Gly Asp Leu Asp Gly Ala Thr Tyr Gly Val Ala Thr Gly Val 
            100                 105                 110         

Asn Ala Tyr Ala Ile Leu Ala Asp Pro Gln Ala Phe Ala Asp Ala Gly 
        115                 120                 125             

Val Asp Met Pro Asp Asp Asp Thr Trp Thr Trp Asp Asp Tyr Val Lys 
    130                 135                 140                 

Ile Ala Ala Glu Ile Ser Glu Lys Ser Asn Gly Glu Ile Val Gly Thr 
145                 150                 155                 160 

Gln Ala Met Gly Tyr Asn Glu Thr Gly Phe Ala Ile Phe Ala Arg Gln 
                165                 170                 175     

His Gly Glu Ser Leu Tyr Thr Glu Asp Gly Lys Leu Gly Phe Ser Lys 
            180                 185                 190         

Lys Thr Leu Glu Lys Trp Phe Gln Tyr Thr Val Asp Leu Leu Glu Ser 
        195                 200                 205             

Gly Ala Gln Pro Gly Ala Ser Glu Ser Val Glu Ile Glu Ala Gly Gly 
    210                 215                 220                 

Pro Asp Gln Ser Val Leu Ala Thr Asn Lys Gly Ala Met Ala His Phe 
225                 230                 235                 240 

Trp Thr Asn Gln Leu Gly Ala Ile Ser Ala Ser Ser Gly Arg Glu Ile 
                245                 250                 255     

Glu Leu Leu Arg Tyr Pro Gly Glu Thr Glu His Glu Arg Thr Gly Met 
            260                 265                 270         

Tyr Phe Lys Pro Ala Met Tyr Tyr Ser Ile Ser Ala Gly Thr Glu His 
        275                 280                 285             

Pro Glu Glu Ala Ala Lys Phe Val Asp Phe Leu Leu Asn Ser Glu Glu 
    290                 295                 300                 

Ala Ala Ala Ile Leu Leu Ala Asp Arg Gly Leu Pro Ala Asn Val Glu 
305                 310                 315                 320 

Val Arg Glu Ser Ile Val Asp Ala Leu Pro Glu Ala Asp Arg Arg Ser 
                325                 330                 335     

Ala Glu Phe Leu Ala Glu Ile Glu Gly Thr Ile Val Asp Gly Asn Pro 
            340                 345                 350         

Pro Pro Pro Ile Gly Ala Gly Gln Val Val Asp Ile Ile Lys Arg Ile 
        355                 360                 365             

Asn Asp Asp Leu Met Phe Gly Arg Leu Thr Pro Ala Glu Ala Ala Asp 
    370                 375                 380                 

Arg Phe Ile Lys Glu Val Glu Asp 
385                 390         

<210>   293
<211>   393
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   293
Val Val Leu Arg Val Ala Trp Trp Gly Gly Gln Glu Arg His Asp Met 
                5                   10                  15      

Thr Ile Glu Ala Ile Glu Leu Phe Glu Glu Lys Tyr Pro His Ile Gln 
            20                  25                  30          

Val Asp Pro Glu Phe Thr Ser Trp Asp Asn Tyr Trp Glu Arg Leu Thr 
        35                  40                  45              

Thr Gln Ala Ala Gly Asn Asn Leu Pro Asp Val Ile Gln Met Asp Asn 
    50                  55                  60                  

Ser Lys Leu Asn Glu Tyr Ser Ser Arg Gly Leu Val Ile Asp Leu Gln 
65                  70                  75                  80  

Ser Leu Ile Ala Asp Gly Thr Ile Asn Leu Asp Asp Val Asp Asp Val 
                85                  90                  95      

Tyr Gln Asp Met Asn Val Gln Asp Gly Ser Val Trp Ala Val Ser Ala 
            100                 105                 110         

Gly Ser Asn Ala Leu Ala Ala Ile Tyr Asn Glu Glu Met Leu Glu Glu 
        115                 120                 125             

Gln Gly Ile Gln Leu Glu Pro Gly Tyr Thr Tyr Glu Asp Phe Tyr Glu 
    130                 135                 140                 

Ala Met Gln Thr Leu Lys Glu Asn Ile Asp Gly Asp Phe Tyr Gly Tyr 
145                 150                 155                 160 

Asp Phe Gly Asn Ala Glu Tyr Glu Met Phe Phe Val Tyr Ala Arg Gln 
                165                 170                 175     

Asn Gly Glu Ser Phe Tyr Asn Glu Asp Gly Thr Gly Leu Gly Phe Glu 
            180                 185                 190         

Asn Gln Thr Leu Ile Asp Phe Leu Thr Phe Val Lys Gln Met Val Asp 
        195                 200                 205             

Asp Gly Val Ala Pro Pro His Ala Leu Thr Leu Glu Tyr Ile Gln Gly 
    210                 215                 220                 

Gly Glu Ser Leu Leu Gly Asp Gln Met Ala Gly Ala Ala Met Ala Ala 
225                 230                 235                 240 

Ser Asn Gly Ile Ile Gly Leu Gln Gln Ser Thr Glu His Gln Leu Gly 
                245                 250                 255     

Leu Met Leu Leu Pro Ser Leu Asp Gly Gly Val His Gly Asn Trp Ile 
            260                 265                 270         

Arg Pro Ser Met Ser Tyr Ser Ile Ser Ser His Ser Glu Glu Gln Glu 
        275                 280                 285             

Ala Ala Ala Leu Phe Ile Asp Phe Leu Thr Asn Asp Leu Gln Ala Asn 
    290                 295                 300                 

Glu Ile Leu Lys Ala Glu Arg Gly Val Pro Ile Ser Ser Lys Val Arg 
305                 310                 315                 320 

Glu His Leu Ala Pro Met Val Asp Gly Pro Ile Ala Lys Thr Phe Glu 
                325                 330                 335     

Phe Leu Glu Leu Val Ala Asp Tyr Thr Ser Pro Ala Asp Pro Leu Pro 
            340                 345                 350         

Pro Pro Gly Glu Ser Glu Val Arg Gly Ala Phe Leu Arg Met Ile Glu 
        355                 360                 365             

Ser Val Lys Tyr Glu Arg Leu Ser Ile Glu Glu Ala Thr Glu Gln Phe 
    370                 375                 380                 

Arg Gln Glu Ala Glu Gln Ile Leu Arg 
385                 390             

<210>   294
<211>   391
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   294
Leu Arg Val Ala Trp Trp Gly Gly Gln Glu Arg His Thr Met Thr Leu 
                5                   10                  15      

Glu Val Ile Asp Leu Phe Glu Glu Lys Tyr Pro Asp Ile Ser Val Glu 
            20                  25                  30          

Pro Glu Tyr Thr Ser Trp Asp Asn Tyr Trp Glu Arg Leu Thr Thr Gln 
        35                  40                  45              

Ala Ala Gly Ser Asn Leu Pro Asp Val Val Gln Leu Asp Tyr Thr Lys 
    50                  55                  60                  

Met Asn Glu Tyr Ile Ser Arg Asn Leu Leu Lys Asp Leu Ala Pro Leu 
65                  70                  75                  80  

Ile Glu Asp Gly Ser Ile Asp Leu Ser Asn Val Asp Asp Val Tyr Gln 
                85                  90                  95      

Asp Val Asn Thr Ile Asp Asp Ala Ile Tyr Gly Ile Ser Leu Gly Ser 
            100                 105                 110         

Asn Ala Leu Gly Met Leu Tyr Asn Ala Glu Leu Phe Ala Glu His Gly 
        115                 120                 125             

Ile Glu Leu Asp Glu Gly Tyr Thr Tyr Glu Asp Met Lys Ala Ser Met 
    130                 135                 140                 

Leu Lys Leu Lys Ser Ala Leu Gly Asp Gly Phe Tyr Gly Tyr Asp Phe 
145                 150                 155                 160 

Asn Asn Thr Glu Phe Asp Leu Phe Phe Ala Tyr Ala Arg Gln Asn Gly 
                165                 170                 175     

Glu Ser Val Phe Asn Glu Thr Gly Asp Gly Leu Gly Tyr Ser Asp Glu 
            180                 185                 190         

Thr Leu Val Ser Tyr Phe Gln Phe Ile Gln Gly Met Val Glu Glu Glu 
        195                 200                 205             

Ala Ala Pro Pro His Glu Leu Thr Met Glu Tyr Ile Gln Gly Gly Asp 
    210                 215                 220                 

Ser Thr Ile Ala Asp Gly Thr Thr Ser Met Leu Leu Ile Ala Ser Asn 
225                 230                 235                 240 

Gln Ile Ile Gly Gln Gln Ala Leu Thr Glu Ala Glu Leu Asp Leu Lys 
                245                 250                 255     

Pro Leu Pro Glu Met Glu Gly Gly Thr Glu Gly Asn Trp Ile Arg Pro 
            260                 265                 270         

Ser Met Ser Phe Ala Ile Ser Glu His Thr Asn Gln Glu Glu His Ala 
        275                 280                 285             

Ala Leu Phe Ile Asp Phe Ile Thr Asn Asp Pro Glu Ala Asn Glu Ile 
    290                 295                 300                 

Leu Gln Ala Glu Arg Gly Val Pro Ile Ser Ala Glu Ile Arg Ser His 
305                 310                 315                 320 

Leu Glu Gly Lys Val Ser Pro Glu Val Glu Lys Thr Phe Ala Tyr Leu 
                325                 330                 335     

Glu Tyr Val Ala Glu Asn Ser Ala Pro Ala Asp Pro Leu Pro Pro Pro 
            340                 345                 350         

Gly Glu Ser Glu Val Arg Ala Ala Phe Leu Arg Val Val Glu Ser Leu 
        355                 360                 365             

Lys Tyr Gly Gln Thr Thr Pro Glu Asp Gly Ala Glu Gln Phe Arg Gln 
    370                 375                 380                 

Gln Ala Glu Ser Ile Leu Lys 
385                 390     

<210>   295
<211>   392
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   295
Leu Arg Val Ala Trp Trp Gly Ser Gln Ala Arg His Asp Arg Thr Ile 
                5                   10                  15      

Glu Ala Ile Lys Leu Phe Glu Ala Glu Asn Pro Asp Ile Ala Ile Thr 
            20                  25                  30          

Thr Glu Phe Thr Gly Trp Asp Gly Tyr Trp Glu Arg Met Ser Thr Gln 
        35                  40                  45              

Ala Ala Gly Arg Asn Leu Pro Asp Val Ile Gln Met Asp Leu Gln Tyr 
    50                  55                  60                  

Ile Asn Glu Tyr Val Ser Arg Asp Leu Leu Val Asp Leu Thr Pro Tyr 
65                  70                  75                  80  

Val Glu Asp Gly Thr Leu Asp Phe Ser Asp Val Asp Asp Ile Tyr Leu 
                85                  90                  95      

Glu Gly Gly Ile Val Asn Glu Gly Leu Tyr Gly Ile Asn Leu Gly Ser 
            100                 105                 110         

Asn Ala Met Ser Ile Ala Tyr Asp Ala Glu Ile Phe Ala Glu Ala Gly 
        115                 120                 125             

Val Pro Glu Leu Glu Pro Gly Tyr Thr Trp Asp Asp Tyr Ile Glu Ala 
    130                 135                 140                 

Val Lys Thr Ile His Glu Asn Leu Asp Gly Met Tyr Ala Tyr Gly Phe 
145                 150                 155                 160 

Gly Asp Ser Leu Asn Phe Phe Lys His Tyr Leu Arg Gln His Asp Leu 
                165                 170                 175     

Trp Leu Tyr Asn Glu Asp Asn Thr Gly Leu Gly Tyr Asp Asp Asp Lys 
            180                 185                 190         

Tyr Leu Ile Asp Phe Leu Asn Met Tyr Lys Asp Leu Leu Asp Ser Gly 
        195                 200                 205             

Val Ala Ala Pro Pro Asp Val Lys Ala Glu Val Gln Gly Ile Gln Asp 
    210                 215                 220                 

Glu Leu Ile Val His Gly Arg Ala Ser Thr Phe Ser Pro His Ser Asn 
225                 230                 235                 240 

Gln Ile Val Ala Leu Asn Glu Ala Ala Gly Arg Lys Leu Gln Met Thr 
                245                 250                 255     

Thr Leu Pro Ala Met Glu Gly Gly Ser Glu Ala Ser Phe Ile Lys Pro 
            260                 265                 270         

Ser Leu Leu Phe Ser Ala Thr Ser Gln Gly Asp Lys Ser Glu Glu Ala 
        275                 280                 285             

Ala Arg Phe Ile Asn Phe Phe Val Asn Ser Ile Glu Ala Asn Glu Ile 
    290                 295                 300                 

Leu Asn Ala Glu Arg Gly Val Pro Ile Ser Glu Lys Val Arg Asp His 
305                 310                 315                 320 

Leu Tyr Asp His Val Ser Glu Asn Thr Gln Leu Gln Phe Asp Tyr Val 
                325                 330                 335     

Gln Leu Val Glu Gln Arg Ala Ala Pro Ile His Pro Pro Asp Pro Ala 
            340                 345                 350         

Gly Thr Gly Gln Ile Leu Asp Leu Tyr Ala Arg Met Ile Glu Glu Phe 
        355                 360                 365             

Glu Tyr Glu Leu Leu Ser Ala Glu Glu Phe Ala Glu Arg Phe Arg Gly 
    370                 375                 380                 

Glu Val Glu Ile Ile Leu Ser Asn 
385                 390         

<210>   296
<211>   389
<212>   PRT
<213>   Agrobacterium tumefaciens str. C58

<400>   296
Trp Trp Gly Ser Gln Glu Arg Ala Asp Arg Thr Asn Lys Ala Ile Ser 
                5                   10                  15      

Ala Tyr Lys Gln Val Lys Pro Asp Leu Asp Ile Ala Gly Glu Phe Ala 
            20                  25                  30          

Gly Trp Ser Asp Tyr Trp Pro Arg Leu Ala Thr Gln Val Ala Gly Arg 
        35                  40                  45              

Asn Ala Pro Asp Leu Ile Gln Met Asp Tyr Arg Tyr Ile Phe Glu Tyr 
    50                  55                  60                  

Gly Arg Arg Gly Ala Leu Ala Pro Leu Asp Asp Tyr Ile Gly Lys Gly 
65                  70                  75                  80  

Leu Lys Ile Glu Asp Phe Gly Lys Met Asn Ile Asp Ser Gly Arg Val 
                85                  90                  95      

Asp Gly Lys Leu Tyr Gly Ile Asn Leu Gly Val Asn Ser Ser Ala Val 
            100                 105                 110         

Phe Phe Asp Lys Ala Ala Trp Glu Lys Ser Gly Ala Thr Pro Pro Ala 
        115                 120                 125             

Thr Gly Gln Thr Trp Glu Glu Phe Ala Glu Asn Ala Ala Arg Leu Ser 
    130                 135                 140                 

Lys Asn Lys Pro Lys Pro Gly Tyr Tyr Ala Thr Ala Asp Ala Ser Gly 
145                 150                 155                 160 

Val Glu Pro Ser Phe Glu Asn Trp Leu Arg Gln Asn Gly Lys Ser Leu 
                165                 170                 175     

Tyr Thr Gln Asp Gly Ala Ile Gly Phe Asp Pro Thr Asp Ala Thr Lys 
            180                 185                 190         

Trp Phe Ser Leu Trp Ala Asp Leu Arg Lys Ser Gly Ala Cys Val Pro 
        195                 200                 205             

Ala Asp Val Gln Ala Leu Asp Gln Leu Asn Ile Glu Thr Asn Pro Leu 
    210                 215                 220                 

Thr Thr Gly Lys Ala Ala Thr Ala Phe Ala His Ser Asn Gln Phe Val 
225                 230                 235                 240 

Gly Tyr Gln Lys Leu Asn Lys Ser Lys Leu Ala Ile Ser Ser Tyr Pro 
                245                 250                 255     

Lys Ser Lys Lys Asp Gly Pro Ser Gly His Tyr Leu Lys Pro Ser Met 
            260                 265                 270         

Leu Ile Ser Val Ala Asn Gly Ser Ala Gly Ile Glu Gln Ala Val Gly 
        275                 280                 285             

Phe Ile Asn Phe Leu Val Ala Glu Pro Glu Gly Ile Asp Ile Leu Gly 
    290                 295                 300                 

Val Glu Arg Gly Val Pro Ala Ser Glu Ser Met Arg Asn Ala Leu Ser 
305                 310                 315                 320 

Ser Lys Leu Asp Glu Val Ser Lys Ile Met Val Asp Tyr Ile Ala Glu 
                325                 330                 335     

Ile Thr Pro Gly Val Gly Asp Leu Pro Pro Ala Pro Pro Pro Gly Ala 
            340                 345                 350         

Gly Glu Phe Ala Phe Val Leu Lys Arg Thr Ala Glu Glu Val Gly Phe 
        355                 360                 365             

Gly Lys Ile Ser Pro Glu Glu Gly Gly Asp Arg Leu Val Lys Glu Ser 
    370                 375                 380                 

Glu Thr Val Ile Lys 
385                 

<210>   297
<211>   448
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   297
Met Lys Arg Gly Gly Ile Arg Met Arg Lys Lys Arg Trp Thr Trp Thr 
                5                   10                  15      

Ala Ser Ala Ala Ala Ala Leu Val Leu Ala Gly Cys Gly Thr Ala Ala 
            20                  25                  30          

Ala Gln Gly Gly Ser Ser Gly Ser Gln Ala Gly Gln Ala Ala Gly Ser 
        35                  40                  45              

Ala Asp Ser Lys Pro Val Val Thr Leu Thr Phe Gly Phe Trp Gly Asp 
    50                  55                  60                  

Ala Lys Glu Glu Ala Val Thr Leu Ala Ala Val Lys Ala Phe Glu Lys 
65                  70                  75                  80  

Ala Tyr Pro Asn Ile His Ile Gln Thr Glu Phe Gly Gly Pro Phe Asn 
                85                  90                  95      

Gln Tyr Phe Thr Lys Leu Ser Thr Glu Val Ala Gly Gly Asn Ala Pro 
            100                 105                 110         

Asp Ile Met Gln Met Asp Tyr Glu Tyr Ile Asp Ala Tyr Ala Lys Glu 
        115                 120                 125             

Gly Gln Leu Leu Asn Leu Lys Gly Ala Lys Gly Ile Asn Ile Ser Thr 
    130                 135                 140                 

Ile Ser Pro Ser Val Leu Lys Ser Gly Tyr Ile Asp Gly Gly Leu Tyr 
145                 150                 155                 160 

Gly Ile Pro Asn Ala Leu Asn Asn Tyr Ala Val Ile Tyr Asp Glu Ala 
                165                 170                 175     

Ala Phe Ala Lys Ala Gly Tyr His Gly Gln Arg Val Ser Trp Gln Gln 
            180                 185                 190         

Trp Ala Asp Ile Leu Glu Lys Val His Lys Ala Thr Gly Lys Trp Ala 
        195                 200                 205             

Glu Asn Asp Asp Glu Ser Trp Gln Thr Phe Gly Tyr Trp Ala Arg Gln 
    210                 215                 220                 

His Gly Gln His Leu Tyr Asn Ala Ser Gly Thr Lys Leu Gly Phe Thr 
225                 230                 235                 240 

Glu Ser Thr Leu Val Ser Tyr Leu Asn Tyr Trp Ala Asn Leu Arg Lys 
                245                 250                 255     

Glu Gly Val Val Pro Pro Gly Thr Val Thr Ser Leu Ile Lys Gln Thr 
            260                 265                 270         

Ala Asp Pro Thr Asp Pro Met Val Gln Gly Lys Ser Glu Ala Glu Leu 
        275                 280                 285             

Thr Trp Val Asn Tyr Val Val Ser Leu Gln Ser Glu Met Thr Arg Ser 
    290                 295                 300                 

Leu Ala Leu Ala Leu Pro Pro Thr Gln Pro Gly Gly Glu Glu Gly Leu 
305                 310                 315                 320 

Tyr Ile Lys Pro Ser Gln Phe Trp Ser Ile Tyr Ser Lys Thr Lys Tyr 
                325                 330                 335     

Pro Gln Gln Ala Glu Leu Phe Val Asn Phe Leu Leu Asn Asn Val Gln 
            340                 345                 350         

Ala Gly Lys Ala Leu Gly Leu Val Arg Gly Ile Pro Val Ser Ser Ser 
        355                 360                 365             

Val Arg Thr Gln Leu Met Ala Ser Gly Thr Ser Ala Pro Glu Lys Ala 
    370                 375                 380                 

Glu Phe Gln Leu Val Asn Glu Ala Leu Lys Val Ala Thr Pro Ile Asp 
385                 390                 395                 400 

Pro Pro Pro Pro Gln His Asp Lys Glu Ile Asp Gln Asp Phe Ala Asn 
                405                 410                 415     

Met Val Gln Ala Val Gln Tyr Gly Lys Glu Thr Pro Gln Gln Gly Ala 
            420                 425                 430         

Glu Gln Phe Met Gln Glu Ala Asn Asp Leu Leu Gln Asn Gly Gly Glu 
        435                 440                 445             

<210>   298
<211>   448
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   298
Met Lys Arg Gly Gly Ile Arg Met Arg Lys Lys Arg Trp Thr Trp Thr 
                5                   10                  15      

Ala Ser Ala Ala Ala Ala Leu Val Leu Ala Gly Cys Gly Thr Ala Ala 
            20                  25                  30          

Ala Gln Gly Gly Ser Ser Gly Ser Gln Ala Gly Gln Ala Ala Gly Ser 
        35                  40                  45              

Ala Asp Ser Lys Pro Val Val Thr Leu Thr Phe Gly Phe Trp Gly Asp 
    50                  55                  60                  

Ala Lys Glu Glu Ala Val Thr Leu Ala Ala Val Lys Ala Phe Glu Lys 
65                  70                  75                  80  

Ala Tyr Pro Asn Ile His Ile Gln Thr Glu Phe Gly Gly Pro Phe Asn 
                85                  90                  95      

Gln Tyr Phe Thr Lys Leu Ser Thr Glu Val Ala Gly Gly Asn Ala Pro 
            100                 105                 110         

Asp Ile Met Gln Met Asp Tyr Glu Tyr Ile Asp Ala Tyr Ala Lys Glu 
        115                 120                 125             

Gly Gln Leu Leu Asn Leu Lys Gly Ala Lys Gly Ile Asn Ile Ser Thr 
    130                 135                 140                 

Ile Ser Pro Ser Val Leu Lys Ser Gly Tyr Ile Asp Gly Gly Leu Tyr 
145                 150                 155                 160 

Gly Ile Pro Asn Ala Leu Asn Asn Tyr Ala Val Ile Tyr Asp Glu Ala 
                165                 170                 175     

Ala Phe Ala Lys Ala Gly Tyr His Gly Gln Arg Val Ser Trp Gln Gln 
            180                 185                 190         

Trp Ala Asp Ile Leu Glu Lys Val His Lys Ala Thr Gly Lys Trp Ala 
        195                 200                 205             

Glu Asn Glu Asp Glu Ser Trp Gln Thr Phe Gly Tyr Trp Ala Arg Gln 
    210                 215                 220                 

His Gly Gln His Leu Tyr Asn Ala Ser Gly Thr Lys Leu Gly Phe Thr 
225                 230                 235                 240 

Glu Ser Thr Leu Val Ser Tyr Leu Asn Tyr Trp Ala Asn Leu Arg Lys 
                245                 250                 255     

Glu Gly Val Val Pro Pro Gly Thr Val Thr Ser Leu Ile Lys Gln Thr 
            260                 265                 270         

Ala Asp Pro Thr Asp Pro Met Val Gln Gly Lys Ser Asp Ala Glu Leu 
        275                 280                 285             

Thr Trp Val Asn Tyr Val Val Ser Leu Gln Ser Glu Met Thr Arg Ser 
    290                 295                 300                 

Leu Ala Leu Ala Leu Pro Pro Thr Gln Pro Gly Gly Glu Glu Gly Leu 
305                 310                 315                 320 

Tyr Ile Lys Pro Ser Gln Phe Trp Ser Ile Tyr Ser Lys Thr Lys Tyr 
                325                 330                 335     

Pro Gln Gln Ala Glu Leu Phe Val Asn Phe Leu Leu Asn Asn Val Gln 
            340                 345                 350         

Ala Gly Lys Ala Leu Gly Leu Val Arg Gly Ile Pro Val Ser Ser Ser 
        355                 360                 365             

Val Arg Thr Gln Leu Met Ala Ser Gly Thr Ser Ala Pro Glu Lys Ala 
    370                 375                 380                 

Glu Phe Gln Leu Val Asn Glu Ala Leu Lys Val Ala Thr Pro Ile Asp 
385                 390                 395                 400 

Pro Pro Pro Pro Gln His Asp Lys Glu Ile Asp Gln Asp Phe Ala Asn 
                405                 410                 415     

Met Val Gln Ala Val Gln Tyr Gly Lys Glu Thr Pro Gln Gln Gly Ala 
            420                 425                 430         

Glu Gln Phe Met Gln Glu Ala Asn Asp Leu Leu Gln Asn Gly Gly Glu 
        435                 440                 445             

<210>   299
<211>   448
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   299
Met Lys Arg Gly Gly Ile Arg Met Arg Lys Lys Arg Trp Thr Trp Thr 
                5                   10                  15      

Ala Ser Ala Ala Ala Ala Leu Val Leu Ala Gly Cys Gly Thr Ala Ala 
            20                  25                  30          

Ala Gln Gly Gly Ser Ser Gly Ser Gln Ala Gly Gln Ala Ala Gly Ser 
        35                  40                  45              

Ala Asp Ser Lys Pro Val Val Thr Leu Thr Phe Gly Phe Trp Gly Asp 
    50                  55                  60                  

Ala Lys Glu Glu Ala Val Thr Leu Ala Ala Val Lys Ala Phe Glu Lys 
65                  70                  75                  80  

Ala Tyr Pro Asn Ile His Ile Gln Thr Glu Phe Gly Gly Pro Phe Asn 
                85                  90                  95      

Gln Tyr Phe Thr Lys Leu Ser Thr Glu Val Ala Gly Gly Asn Ala Pro 
            100                 105                 110         

Asp Ile Met Gln Met Asp Tyr Glu Tyr Ile Asp Ala Tyr Ala Lys Glu 
        115                 120                 125             

Gly Gln Leu Leu Asn Leu Lys Gly Ala Lys Gly Ile Asn Ile Ser Thr 
    130                 135                 140                 

Ile Ser Pro Ser Val Leu Lys Ser Gly Tyr Ile Asp Gly Gly Leu Tyr 
145                 150                 155                 160 

Gly Ile Pro Asn Ala Leu Asn Asn Tyr Ala Val Leu Tyr Asp Glu Ala 
                165                 170                 175     

Ala Phe Ala Lys Ala Gly Tyr His Gly Gln Arg Val Ser Trp Gln Gln 
            180                 185                 190         

Trp Ala Asp Ile Leu Glu Lys Val His Lys Ala Thr Gly Lys Trp Ala 
        195                 200                 205             

Glu Asn Asp Asp Glu Ser Trp Gln Thr Phe Gly Tyr Trp Ala Arg Gln 
    210                 215                 220                 

His Gly Gln His Leu Tyr Asn Ala Ser Gly Thr Lys Leu Gly Phe Thr 
225                 230                 235                 240 

Glu Ser Thr Leu Val Ser Tyr Leu Asn Tyr Trp Ala Asn Leu Arg Lys 
                245                 250                 255     

Glu Gly Val Val Pro Pro Gly Thr Val Thr Ser Leu Ile Lys Gln Thr 
            260                 265                 270         

Ala Asp Pro Thr Asp Pro Met Val Gln Gly Lys Ser Asp Ala Glu Leu 
        275                 280                 285             

Thr Trp Val Asn Tyr Val Val Ser Leu Gln Ser Glu Met Thr Arg Ser 
    290                 295                 300                 

Leu Ala Leu Ala Leu Pro Pro Thr Gln Pro Gly Gly Glu Glu Gly Leu 
305                 310                 315                 320 

Tyr Ile Lys Pro Ser Gln Phe Trp Ser Ile Tyr Ser Lys Thr Lys Tyr 
                325                 330                 335     

Pro Gln Gln Ala Glu Leu Phe Val Asn Phe Leu Leu Asn Asn Val Gln 
            340                 345                 350         

Ala Gly Lys Ala Leu Gly Leu Val Arg Gly Ile Pro Val Ser Ser Ser 
        355                 360                 365             

Val Arg Thr Gln Leu Met Ala Ser Gly Thr Ser Ala Pro Glu Lys Ala 
    370                 375                 380                 

Glu Phe Gln Leu Val Asn Glu Ala Leu Lys Val Ala Thr Pro Ile Asp 
385                 390                 395                 400 

Pro Pro Pro Pro Gln His Asp Lys Glu Ile Asp Gln Asp Phe Ala Asn 
                405                 410                 415     

Met Val Gln Ala Val Gln Tyr Gly Lys Glu Thr Pro Gln Gln Gly Ala 
            420                 425                 430         

Glu Gln Phe Met Gln Glu Ala Asn Asp Leu Leu Gln Asn Gly Gly Glu 
        435                 440                 445             

<210>   300
<211>   448
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   300
Met Lys Arg Gly Gly Ile Arg Met Arg Lys Lys Arg Trp Thr Trp Thr 
                5                   10                  15      

Ala Ser Ala Ala Ala Ala Leu Val Leu Ala Gly Cys Gly Thr Ala Ala 
            20                  25                  30          

Ala Gln Gly Gly Ser Ser Gly Ser Gln Ala Gly Gln Ala Ala Gly Ser 
        35                  40                  45              

Ala Asp Ser Lys Pro Val Val Thr Leu Thr Phe Gly Phe Trp Gly Asp 
    50                  55                  60                  

Ala Lys Glu Glu Ala Val Thr Leu Ala Ala Val Lys Ala Phe Glu Lys 
65                  70                  75                  80  

Ala Tyr Pro Asn Ile His Ile Gln Thr Glu Phe Gly Gly Pro Phe Asn 
                85                  90                  95      

Gln Tyr Phe Thr Lys Leu Ser Thr Glu Val Ala Gly Gly Asn Ala Pro 
            100                 105                 110         

Asp Ile Met Gln Met Asp Tyr Glu Tyr Ile Asp Ala Tyr Ala Lys Glu 
        115                 120                 125             

Gly Gln Leu Leu Asn Leu Lys Gly Ala Lys Gly Ile Asn Ile Ser Thr 
    130                 135                 140                 

Ile Ser Pro Ser Val Leu Lys Ser Gly Tyr Ile Asp Gly Gly Leu Tyr 
145                 150                 155                 160 

Gly Ile Pro Asn Ala Leu Asn Asn Tyr Ala Val Ile Tyr Asp Glu Ala 
                165                 170                 175     

Ala Phe Ala Lys Ala Gly Tyr His Gly Gln Arg Val Ser Trp Gln Gln 
            180                 185                 190         

Trp Ala Asp Ile Leu Glu Lys Val His Lys Ala Thr Gly Lys Trp Ala 
        195                 200                 205             

Glu Asn Asp Asp Glu Ser Trp Gln Thr Phe Gly Tyr Trp Ala Arg Gln 
    210                 215                 220                 

His Gly Gln His Leu Tyr Asn Ala Ser Gly Thr Lys Leu Gly Phe Thr 
225                 230                 235                 240 

Glu Ser Thr Leu Val Ser Tyr Leu Asn Tyr Trp Ala Asn Leu Arg Lys 
                245                 250                 255     

Glu Gly Val Val Pro Pro Gly Thr Val Thr Ser Leu Ile Lys Gln Thr 
            260                 265                 270         

Ala Asp Pro Thr Asp Pro Met Val Gln Gly Lys Ser Asp Ala Glu Leu 
        275                 280                 285             

Thr Trp Val Asn Tyr Val Val Ser Leu Gln Ser Glu Met Thr Arg Ser 
    290                 295                 300                 

Leu Ala Leu Ala Leu Pro Pro Thr Gln Pro Gly Gly Glu Glu Gly Leu 
305                 310                 315                 320 

Tyr Ile Lys Pro Ser Gln Phe Trp Ser Ile Tyr Ser Lys Thr Lys Tyr 
                325                 330                 335     

Pro Gln Gln Ala Glu Leu Phe Val Asn Phe Leu Leu Asn Asn Val Gln 
            340                 345                 350         

Ala Gly Lys Ala Leu Gly Leu Val Arg Gly Ile Pro Val Ser Ser Ser 
        355                 360                 365             

Val Arg Thr Gln Leu Met Ala Ser Gly Thr Ser Ala Pro Glu Lys Ala 
    370                 375                 380                 

Glu Phe Gln Leu Val Asn Glu Ala Leu Lys Val Ala Thr Pro Ile Asp 
385                 390                 395                 400 

Pro Pro Pro Pro Gln His Asp Lys Glu Ile Asp Gln Asp Phe Ala Asn 
                405                 410                 415     

Met Val Gln Ala Val Gln Tyr Gly Lys Glu Thr Pro Gln Asn Gly Ala 
            420                 425                 430         

Glu Gln Phe Met Gln Glu Ala Asn Asp Leu Leu Gln Asn Gly Gly Glu 
        435                 440                 445             

<210>   301
<211>   448
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   301
Met Lys Arg Gly Gly Ile Arg Met Arg Lys Lys Arg Trp Thr Trp Thr 
                5                   10                  15      

Ala Ser Ala Ala Ala Ala Leu Val Leu Ala Gly Cys Gly Thr Ala Ala 
            20                  25                  30          

Ala Gln Gly Gly Ser Ser Gly Ser Gln Ala Gly Gln Ala Ala Gly Ser 
        35                  40                  45              

Ala Asp Ser Lys Pro Val Val Thr Leu Thr Phe Gly Phe Trp Gly Asp 
    50                  55                  60                  

Ala Lys Glu Glu Ala Val Thr Leu Ala Ala Val Lys Ala Phe Glu Lys 
65                  70                  75                  80  

Ala Tyr Pro Asn Ile His Ile Gln Thr Glu Phe Gly Gly Pro Phe Asn 
                85                  90                  95      

Gln Tyr Phe Thr Lys Leu Ser Thr Glu Val Ala Gly Gly Asn Ala Pro 
            100                 105                 110         

Asp Ile Met Gln Met Asp Tyr Glu Tyr Ile Asp Ala Tyr Ala Lys Glu 
        115                 120                 125             

Gly Gln Leu Leu Asn Leu Lys Gly Ala Lys Gly Ile Asn Ile Ser Thr 
    130                 135                 140                 

Ile Ser Pro Ser Val Leu Lys Ser Gly Tyr Ile Asp Gly Gly Leu Tyr 
145                 150                 155                 160 

Gly Ile Pro Asn Ala Leu Asn Asn Tyr Ala Val Ile Tyr Asp Glu Ala 
                165                 170                 175     

Ala Phe Ala Lys Ala Gly Tyr His Gly Gln Arg Val Ser Trp Gln Gln 
            180                 185                 190         

Trp Ala Asp Ile Leu Glu Lys Val His Lys Ala Thr Gly Lys Trp Ala 
        195                 200                 205             

Glu Asn Asp Asp Glu Ser Trp Gln Thr Phe Gly Tyr Trp Ala Arg Gln 
    210                 215                 220                 

His Gly Gln His Leu Tyr Asn Ala Ser Gly Thr Lys Ile Gly Phe Thr 
225                 230                 235                 240 

Glu Ser Thr Leu Val Ser Tyr Leu Asn Tyr Trp Ala Asn Leu Arg Lys 
                245                 250                 255     

Glu Gly Val Val Pro Pro Gly Thr Val Thr Ser Leu Ile Lys Gln Thr 
            260                 265                 270         

Ala Asp Pro Thr Asp Pro Met Val Gln Gly Lys Ser Asp Ala Glu Leu 
        275                 280                 285             

Thr Trp Val Asn Tyr Val Val Ser Leu Gln Ser Glu Met Thr Arg Ser 
    290                 295                 300                 

Leu Ala Leu Ala Leu Pro Pro Thr Gln Pro Gly Gly Glu Glu Gly Leu 
305                 310                 315                 320 

Tyr Ile Lys Pro Ser Gln Phe Trp Ser Ile Tyr Ser Lys Thr Lys Tyr 
                325                 330                 335     

Pro Gln Gln Ala Glu Leu Phe Val Asn Phe Leu Leu Asn Asn Val Gln 
            340                 345                 350         

Ala Gly Lys Ala Leu Gly Leu Val Arg Gly Ile Pro Val Ser Ser Ser 
        355                 360                 365             

Val Arg Thr Gln Leu Met Ala Ser Gly Thr Ser Ala Pro Glu Lys Ala 
    370                 375                 380                 

Glu Phe Gln Leu Val Asn Glu Ala Leu Lys Val Ala Thr Pro Ile Asp 
385                 390                 395                 400 

Pro Pro Pro Pro Gln His Asp Lys Glu Ile Asp Gln Asp Phe Ala Asn 
                405                 410                 415     

Met Val Gln Ala Val Gln Tyr Gly Lys Glu Thr Pro Gln Gln Gly Ala 
            420                 425                 430         

Glu Gln Phe Met Gln Glu Ala Asn Asp Leu Leu Gln Asn Gly Gly Glu 
        435                 440                 445             

<210>   302
<211>   1347
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   302
gtgaaacgag gaggaatccg catgcgaaaa aagagatgga catggacggc gagcgccgcg       60

gctgcgctgg tgttggcggg ctgcggcacc gcggcggcgc agggcggttc gagtgggtcg      120

caagccgggc aggccgcggg aagcgcggac tcgaagccgg tggtcacgct caccttcggc      180

ttctggggcg atgcgaagga agaggcggtc acgctggccg cggtgaaagc gtttgagaag      240

gcgtatccga acattcacat ccagaccgaa ttcggagggc cattcaatca gtacttcacg      300

aagctgtcca ccgaggtcgc gggcggcaac gcaccagaca tcatgcagat ggattacgaa      360

tacattgacg cctacgccaa ggaaggccag ttgctcaacc tgaagggcgc gaagggaatc      420

aacatctcca ccatcagccc gagcgtcctg aagagcggct acatcgacgg cgggttgtat      480

ggcattccga atgcgctgaa taactatgcg gtcatctacg acgaggccgc gtttgccaag      540

gcgggctatc acggccaacg cgtttcatgg caacagtggg cggatatcct cgaaaaggtc      600

cataaggcga caggcaagtg ggccgagaac gacgacgaga gctggcagac ctttggatac      660

tgggcgcgcc agcacggtca gcacctatac aacgcctccg ggacgaagct cggatttacc      720

gagagcacgc tcgtctccta tctgaactac tgggcgaatc ttcgcaaaga gggcgttgtg      780

ccgcccggga ccgtgacatc cctcatcaag cagacggccg atccgacgga tccgatggtg      840

caagggaaat cggaagcgga actcacctgg gtcaactacg tcgtcagcct gcagagcgag      900

atgacgcgaa gcttggcgct ggcccttccg ccgacacagc cgggtggaga ggagggcctg      960

tatatcaagc cgagccagtt ctggagcatc tattccaaga cgaagtatcc gcagcaagcc     1020

gagctctttg tcaacttctt gctgaacaac gtccaagcgg gcaaggcgct cgggctcgtg     1080

cgcggcatcc cggtgtcgtc ctccgtccgc actcagttga tggcatccgg cacctcggcg     1140

cctgaaaagg ccgagttcca gctggtgaac gaggcgctca aggtggccac gcccatcgat     1200

cctccgccgc cgcagcacga caaggagatc gaccaggact tcgcgaacat ggtccaggct     1260

gtgcaatacg gcaaggaaac gccccagcag ggcgccgaac agtttatgca ggaggcgaac     1320

gatctcctgc agaacggcgg cgagtga                                         1347


<210>   303
<211>   1347
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   303
gtgaaacgag gaggaatccg catgcgaaaa aagagatgga catggacggc gagcgccgcg       60

gctgcgctgg tgttggcggg ctgcggcacc gcggcggcgc agggcggttc gagtgggtcg      120

caagccgggc aggccgcggg aagcgcggac tcgaagccgg tggtcacgct caccttcggc      180

ttctggggcg atgcgaagga agaggcggtc acgctggccg cggtgaaagc gtttgagaag      240

gcgtatccga acattcacat ccagaccgaa ttcggagggc cattcaatca gtacttcacg      300

aagctgtcca ccgaggtcgc gggcggcaac gcaccagaca tcatgcagat ggattacgaa      360

tacattgacg cctacgccaa ggaaggccag ttgctcaacc tgaagggcgc gaagggaatc      420

aacatctcca ccatcagccc gagcgtcctg aagagcggct acatcgacgg cgggttgtat      480

ggcattccga atgcgctgaa taactatgcg gtcatctacg acgaggccgc gtttgccaag      540

gcgggctatc acggccaacg cgtttcatgg caacagtggg cggatatcct cgaaaaggtc      600

cataaggcga caggcaagtg ggccgagaac gaagacgaga gctggcagac ctttggatac      660

tgggcgcgcc agcacggtca gcacctatac aacgcctccg ggacgaagct cggatttacc      720

gagagcacgc tcgtctccta tctgaactac tgggcgaatc ttcgcaaaga gggcgttgtg      780

ccgcccggga ccgtgacatc cctcatcaag cagacggccg atccgacgga tccgatggtg      840

caagggaaat cggatgcgga actcacctgg gtcaactacg tcgtcagcct gcagagcgag      900

atgacgcgaa gcttggcgct ggcccttccg ccgacacagc cgggtggaga ggagggcctg      960

tatatcaagc cgagccagtt ctggagcatc tattccaaga cgaagtatcc gcagcaagcc     1020

gagctctttg tcaacttctt gctgaacaac gtccaagcgg gcaaggcgct cgggctcgtg     1080

cgcggcatcc cggtgtcgtc ctccgtccgc actcagttga tggcatccgg cacctcggcg     1140

cctgaaaagg ccgagttcca gctggtgaac gaggcgctca aggtggccac gcccatcgat     1200

cctccgccgc cgcagcacga caaggagatc gaccaggact tcgcgaacat ggtccaggct     1260

gtgcaatacg gcaaggaaac gccccagcag ggcgccgaac agtttatgca ggaggcgaac     1320

gatctcctgc agaacggcgg cgagtga                                         1347


<210>   304
<211>   1347
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   304
gtgaaacgag gaggaatccg catgcgaaaa aagagatgga catggacggc gagcgccgcg       60

gctgcgctgg tgttggcggg ctgcggcacc gcggcggcgc agggcggttc gagtgggtcg      120

caagccgggc aggccgcggg aagcgcggac tcgaagccgg tggtcacgct caccttcggc      180

ttctggggcg atgcgaagga agaggcggtc acgctggccg cggtgaaagc gtttgagaag      240

gcgtatccga acattcacat ccagaccgaa ttcggagggc cattcaatca gtacttcacg      300

aagctgtcca ccgaggtcgc gggcggcaac gcaccagaca tcatgcagat ggattacgaa      360

tacattgacg cctacgccaa ggaaggccag ttgctcaacc tgaagggcgc gaagggaatc      420

aacatctcca ccatcagccc gagcgtcctg aagagcggct acatcgacgg cgggttgtat      480

ggcattccga atgcgctgaa taactatgcg gtcttatacg acgaggccgc gtttgccaag      540

gcgggctatc acggccaacg cgtttcatgg caacagtggg cggatatcct cgaaaaggtc      600

cataaggcga caggcaagtg ggccgagaac gacgacgaga gctggcagac ctttggatac      660

tgggcgcgcc agcacggtca gcacctatac aacgcctccg ggacgaagct cggatttacc      720

gagagcacgc tcgtctccta tctgaactac tgggcgaatc ttcgcaaaga gggcgttgtg      780

ccgcccggga ccgtgacatc cctcatcaag cagacggccg atccgacgga tccgatggtg      840

caagggaaat cggatgcgga actcacctgg gtcaactacg tcgtcagcct gcagagcgag      900

atgacgcgaa gcttggcgct ggcccttccg ccgacacagc cgggtggaga ggagggcctg      960

tatatcaagc cgagccagtt ctggagcatc tattccaaga cgaagtatcc gcagcaagcc     1020

gagctctttg tcaacttctt gctgaacaac gtccaagcgg gcaaggcgct cgggctcgtg     1080

cgcggcatcc cggtgtcgtc ctccgtccgc actcagttga tggcatccgg cacctcggcg     1140

cctgaaaagg ccgagttcca gctggtgaac gaggcgctca aggtggccac gcccatcgat     1200

cctccgccgc cgcagcacga caaggagatc gaccaggact tcgcgaacat ggtccaggct     1260

gtgcaatacg gcaaggaaac gccccagcag ggcgccgaac agtttatgca ggaggcgaac     1320

gatctcctgc agaacggcgg cgagtga                                         1347


<210>   305
<211>   1347
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   305
gtgaaacgag gaggaatccg catgcgaaaa aagagatgga catggacggc gagcgccgcg       60

gctgcgctgg tgttggcggg ctgcggcacc gcggcggcgc agggcggttc gagtgggtcg      120

caagccgggc aggccgcggg aagcgcggac tcgaagccgg tggtcacgct caccttcggc      180

ttctggggcg atgcgaagga agaggcggtc acgctggccg cggtgaaagc gtttgagaag      240

gcgtatccga acattcacat ccagaccgaa ttcggagggc cattcaatca gtacttcacg      300

aagctgtcca ccgaggtcgc gggcggcaac gcaccagaca tcatgcagat ggattacgaa      360

tacattgacg cctacgccaa ggaaggccag ttgctcaacc tgaagggcgc gaagggaatc      420

aacatctcca ccatcagccc gagcgtcctg aagagcggct acatcgacgg cgggttgtat      480

ggcattccga atgcgctgaa taactatgcg gtcatctacg acgaggccgc gtttgccaag      540

gcgggctatc acggccaacg cgtttcatgg caacagtggg cggatatcct cgaaaaggtc      600

cataaggcga caggcaagtg ggccgagaac gacgacgaga gctggcagac ctttggatac      660

tgggcgcgcc agcacggtca gcacctatac aacgcctccg ggacgaagct cggatttacc      720

gagagcacgc tcgtctccta tctgaactac tgggcgaatc ttcgcaaaga gggcgttgtg      780

ccgcccggga ccgtgacatc cctcatcaag cagacggccg atccgacgga tccgatggtg      840

caagggaaat cggatgcgga actcacctgg gtcaactacg tcgtcagcct gcagagcgag      900

atgacgcgaa gcttggcgct ggcccttccg ccgacacagc cgggtggaga ggagggcctg      960

tatatcaagc cgagccagtt ctggagcatc tattccaaga cgaagtatcc gcagcaagcc     1020

gagctctttg tcaacttctt gctgaacaac gtccaagcgg gcaaggcgct cgggctcgtg     1080

cgcggcatcc cggtgtcgtc ctccgtccgc actcagttga tggcatccgg cacctcggcg     1140

cctgaaaagg ccgagttcca gctggtgaac gaggcgctca aggtggccac gcccatcgat     1200

cctccgccgc cgcagcacga caaggagatc gaccaggact tcgcgaacat ggtccaggct     1260

gtgcaatacg gcaaggaaac gccccagaat ggcgccgaac agtttatgca ggaggcgaac     1320

gatctcctgc agaacggcgg cgagtga                                         1347


<210>   306
<211>   1347
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   306
gtgaaacgag gaggaatccg catgcgaaaa aagagatgga catggacggc gagcgccgcg       60

gctgcgctgg tgttggcggg ctgcggcacc gcggcggcgc agggcggttc gagtgggtcg      120

caagccgggc aggccgcggg aagcgcggac tcgaagccgg tggtcacgct caccttcggc      180

ttctggggcg atgcgaagga agaggcggtc acgctggccg cggtgaaagc gtttgagaag      240

gcgtatccga acattcacat ccagaccgaa ttcggagggc cattcaatca gtacttcacg      300

aagctgtcca ccgaggtcgc gggcggcaac gcaccagaca tcatgcagat ggattacgaa      360

tacattgacg cctacgccaa ggaaggccag ttgctcaacc tgaagggcgc gaagggaatc      420

aacatctcca ccatcagccc gagcgtcctg aagagcggct acatcgacgg cgggttgtat      480

ggcattccga atgcgctgaa taactatgcg gtcatctacg acgaggccgc gtttgccaag      540

gcgggctatc acggccaacg cgtttcatgg caacagtggg cggatatcct cgaaaaggtc      600

cataaggcga caggcaagtg ggccgagaac gacgacgaga gctggcagac ctttggatac      660

tgggcgcgcc agcacggtca gcacctatac aacgcctccg ggacgaagat tggatttacc      720

gagagcacgc tcgtctccta tctgaactac tgggcgaatc ttcgcaaaga gggcgttgtg      780

ccgcccggga ccgtgacatc cctcatcaag cagacggccg atccgacgga tccgatggtg      840

caagggaaat cggatgcgga actcacctgg gtcaactacg tcgtcagcct gcagagcgag      900

atgacgcgaa gcttggcgct ggcccttccg ccgacacagc cgggtggaga ggagggcctg      960

tatatcaagc cgagccagtt ctggagcatc tattccaaga cgaagtatcc gcagcaagcc     1020

gagctctttg tcaacttctt gctgaacaac gtccaagcgg gcaaggcgct cgggctcgtg     1080

cgcggcatcc cggtgtcgtc ctccgtccgc actcagttga tggcatccgg cacctcggcg     1140

cctgaaaagg ccgagttcca gctggtgaac gaggcgctca aggtggccac gcccatcgat     1200

cctccgccgc cgcagcacga caaggagatc gaccaggact tcgcgaacat ggtccaggct     1260

gtgcaatacg gcaaggaaac gccccagcag ggcgccgaac agtttatgca ggaggcgaac     1320

gatctcctgc agaacggcgg cgagtga                                         1347


<210>   307
<211>   299
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   307
Met Met Lys Glu Gly Ser Pro Val Pro Arg Gly Ala Ser Asn Glu Arg 
                5                   10                  15      

Val Glu Ala Leu Val Arg Leu Leu Gly Leu Glu Pro Ser Glu Lys Pro 
            20                  25                  30          

Arg Ser Leu Ser Glu Leu Val Ala Asp Arg Glu Val His Val Leu Leu 
        35                  40                  45              

Pro Glu Gly Thr Ala Pro Ala Gly Gly Tyr Pro Thr Ala Val Leu Ile 
    50                  55                  60                  

His Gly His Ser Pro Leu Gly Tyr Asp Tyr Phe Arg Ser Ala Asn Glu 
65                  70                  75                  80  

Val Tyr Val Lys Gly Ala Pro Val Ala Glu Leu Leu Arg Asp Ala Gly 
                85                  90                  95      

Phe Ala Val Val Leu Pro Ser Leu Arg Gly Phe Gly Ala Thr Met Asp 
            100                 105                 110         

Pro Val Asp Arg Ala Leu Gly Leu Glu His Ser Cys Glu Arg Phe Ala 
        115                 120                 125             

Arg Gln Arg Leu Leu Val Gly Arg Thr Leu Leu Gly Asp Arg Val Arg 
    130                 135                 140                 

Asp Leu Met Glu Leu Leu Asp Ala Met Glu Met Asp Gly Arg Phe Asp 
145                 150                 155                 160 

Ile Glu Ser Leu Val Thr Ala Gly Phe Ser Gly Gly Gly Thr Ala Ala 
                165                 170                 175     

Leu Phe His Ala Ala Cys Asp Ser Arg Val Arg His Leu Ile Leu Leu 
            180                 185                 190         

Ser Ala Leu Cys Thr Ala Arg His Ser Leu Leu Ala Thr Arg His Cys 
        195                 200                 205             

Leu Cys Asn Tyr Val Pro Gly Leu Leu Asn Phe Gly Asp Trp Gly Asp 
    210                 215                 220                 

Val Ala Ala Leu Val Ala Pro Arg Arg Leu Thr Ile Val His Gly Glu 
225                 230                 235                 240 

Arg Asp Gly Val Phe Pro Phe Glu Gly Ala Arg Ala Ala Phe Ala Ala 
                245                 250                 255     

Val Glu Ala Ala Tyr Glu Ala Val Gly Met Thr Lys Arg Ala Met Phe 
            260                 265                 270         

Leu Ala Gln Pro Gly Gly His Glu Pro Tyr Pro Glu Val Leu Trp Gln 
        275                 280                 285             

Leu Met Gly Val Gly Leu Lys Arg Ala Thr Thr 
    290                 295                 

<210>   308
<211>   900
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   308
gtgatgaagg agggaagccc ggtgccgcga ggggcgtcga acgaacgagt ggaggccctc       60

gttcggctgc tcggcctgga gccctcggag aagccgagat ccttgagcga actcgtggcg      120

gatcgcgaag tccacgtgct ccttccggag ggcacggcgc ccgcgggcgg ctatcccacc      180

gccgtgttga tccacggcca ttcgccgctc ggctacgatt actttcgcag cgcgaacgag      240

gtgtacgtca agggcgcacc cgtggcggag cttttgcgcg acgcgggctt tgcggtggtg      300

ctcccgtctt tgcgcgggtt tggcgccacg atggacccgg tcgatcgcgc cctgggcctg      360

gagcacagct gtgagcggtt cgcgcggcag cgactgctcg tcggccggac gctcctcggc      420

gatcgcgtcc gcgatctgat ggaactcctg gatgcgatgg agatggacgg ccgcttcgac      480

atagagagcc ttgtcacggc gggattttca ggcggcggca cggccgcgct gtttcacgcg      540

gcctgcgatt cgcgggtccg ccacctgatc ctgctgtcgg cgttgtgcac cgcccggcat      600

tcgctccttg ctacgcggca ctgcctgtgc aactacgtac cgggtcttct gaacttcggc      660

gattgggggg atgtggcggc gctcgtggcg ccgcggcgcc tgaccattgt gcatggcgaa      720

cgcgacggcg tgtttccgtt cgagggtgcg cgtgcagcgt ttgcagcggt cgaagcggcg      780

tacgaggccg tgggtatgac aaagcgtgcg atgtttcttg cacaacctgg gggtcatgag      840

ccgtatccgg aggttttgtg gcagttgatg ggtgtcggtc tcaagcgtgc gacaacgtga      900

                                                                       900


<210>   309
<211>   191
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   309
Pro Thr Val Leu Ala Leu His Gly His Gly Tyr Gly Met Lys Glu Ala 
                5                   10                  15      

Ile Gly Leu Asn Ile Asn Gly Glu Gln Cys Lys Phe Thr Gly Ile His 
            20                  25                  30          

Asn Lys Phe Ala Ala Arg Leu Val Asn Lys Gly Val Ile Val Val Val 
        35                  40                  45              

Pro Gly Ile Ile Gly Phe Gly Asp Arg Arg Leu Asp Glu Asp Met Asn 
    50                  55                  60                  

Ala Glu Gln Pro Leu Glu Asn Ser Cys Phe Glu Ile Gly Ser Gln Leu 
65                  70                  75                  80  

Leu Leu Met Gly Lys Thr Leu Ala Gly Leu Arg Val Gln Glu Ile Lys 
                85                  90                  95      

Arg Val Leu Asp Tyr Ile Gln Ser Phe Asn Met Val Asp Glu Glu Lys 
            100                 105                 110         

Ile Gly Ser Phe Gly Phe Ser Gly Gly Gly Leu Val Ala Ala Phe Thr 
        115                 120                 125             

Ser Ile Leu Asp Glu Arg Ile Lys Ala Thr Val Leu Ser Gly Tyr Leu 
    130                 135                 140                 

Ser Thr Phe Lys Gly Ser Ile Met Ser Arg Arg His Cys Leu Asp Asn 
145                 150                 155                 160 

Tyr Ile Pro Gly Ile Leu Glu Ile Gly Glu Met Asp Glu Leu Ile Ala 
                165                 170                 175     

Leu Ile Ala Pro Arg Pro Leu Phe Ile Glu Ser Gly Lys Asp Asp 
            180                 185                 190     

<210>   310
<211>   260
<212>   PRT
<213>   Victivallis vadensis ATCC BAA-548

<400>   310
Glu Lys Leu Arg Phe Ser Pro Glu Glu Gly Glu Glu Ala Cys Ile Tyr 
                5                   10                  15      

Ile Cys Leu Pro Glu Leu Pro Pro Pro Tyr Lys Thr Phe Ile Cys Leu 
            20                  25                  30          

Gln Gly His Ser Thr Gly Met His Asn Ser Ile Ala Val Glu Trp Gln 
        35                  40                  45              

Asp Glu Thr Val Pro Lys Ala Ile Glu Gly Asp Arg Asp Phe Ala Ile 
    50                  55                  60                  

Gly Cys Leu Lys Arg Gly Ile Ala Ala Val Cys Leu Glu Gln Arg Tyr 
65                  70                  75                  80  

Met Gly Glu Arg Ser Ser Asp Pro Glu His His Pro Ala Cys Leu Leu 
                85                  90                  95      

Pro Thr Leu Gln Asn Leu Met Ile Gly Arg Thr Ala Ile Gly Asp Arg 
            100                 105                 110         

Val Tyr Asp Val Asp Arg Leu Ile Asp Tyr Leu Tyr Thr Arg Gly Asp 
        115                 120                 125             

Ile Asp Arg Thr Arg Leu Gly Val Met Gly Asn Ser Gly Gly Gly Thr 
    130                 135                 140                 

Thr Gly Met Phe Ala Gly Ala Val Leu Asp Arg Ile Thr His Val Ile 
145                 150                 155                 160 

Ala Ser Cys Ser Phe Ser Ser Phe Arg Gly Ser Ile Gly Ser Met Phe 
                165                 170                 175     

His Cys Ala Cys Asn Tyr Val Pro Gly Leu Leu Glu Tyr Gly Glu Ser 
            180                 185                 190         

Ala Asp Val Val Gly Leu Thr Ala Pro Lys Pro Val Val Ile Val Asn 
        195                 200                 205             

Gly Asp Ala Asp Glu Ile Phe Pro Leu Asp Glu Ala Asp Arg Gln Phe 
    210                 215                 220                 

Arg Arg Leu Glu Ala Val Tyr Arg Ala Ala Gly Ala Ala Gly Asn Cys 
225                 230                 235                 240 

Val His Ala Val Gly Gly Gly Gly His Arg Phe Tyr Ala Ala Glu Ala 
                245                 250                 255     

Trp Ser Ala Met 
            260 

<210>   311
<211>   182
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   311
Pro Val Gly Gly Asn Arg Glu Ala Val Val Leu Ala Leu His Gly His 
                5                   10                  15      

Gly Ala Gly Ala Glu Glu Ala Leu Gln Glu Asp Ser Ser His Asn Ala 
            20                  25                  30          

Phe Ala Leu Lys Leu Val Glu Gln Gly Ala Val Val Val Leu Pro Glu 
        35                  40                  45              

Leu Ala Gly Phe Gly Ala Arg Lys Arg Lys Gln Asp Gln Ala Glu Lys 
    50                  55                  60                  

Asn Ser Cys Phe Ser Ile Ala Ser His Leu Leu Leu Tyr Gly Lys Thr 
65                  70                  75                  80  

Leu Ala Gly Leu Arg Val Phe Glu Cys Ala Arg Leu Leu Asp Trp Val 
                85                  90                  95      

Gly Glu Thr Arg Arg Gly Asn Val Gly Cys Ile Gly Phe Ser Gly Gly 
            100                 105                 110         

Ala Leu Ile Ala Leu Leu Leu Ala Ala Thr Asp Glu Arg Ile Lys Ala 
        115                 120                 125             

Thr Val Leu Ser Gly Phe Ala Ser Leu Met Arg Asp Ser Ile Leu Ala 
    130                 135                 140                 

Ser Arg His Cys Leu Asp Asn Tyr Ile Pro Gly Leu Leu Ala Ile Gly 
145                 150                 155                 160 

Glu Thr Pro Gln Leu Leu Glu Leu Ile Asn Pro Arg Ala Leu Phe Val 
                165                 170                 175     

Glu Ser Gly Asn Asp Asp 
            180         

<210>   312
<211>   192
<212>   PRT
<213>   Planctomyces maris DSM 8797

<400>   312
Pro Ala Ile Val Cys Met His Gly His Ser Gly Ile Ile Pro Tyr Ile 
                5                   10                  15      

Asp Glu Gly Lys Thr Lys Ala Asp Lys Glu Lys Thr Arg Gln Ser Glu 
            20                  25                  30          

Leu Asp Tyr Ala Val Tyr Phe Ala Lys His Gly Tyr Ile Thr Ala Ala 
        35                  40                  45              

Ile Val Met Arg Gly Trp Asn Glu Thr Ala Gly Asp Gln Asp Arg Gly 
    50                  55                  60                  

Val Ser His Thr Lys Arg Ser Cys Leu Gln Met Thr Met Asn Ala Leu 
65                  70                  75                  80  

Leu Ile Gly Ser Thr Pro Gln Gly Gln Arg Ser Trp Asp Ala Met Arg 
                85                  90                  95      

Val Ile Asp Phe Leu Gln Thr Gln Asp Gln Val Asp Pro Asp Arg Ile 
            100                 105                 110         

Ala Ala Ala Gly Leu Ser Gly Gly Gly Ala Thr Ala Met Tyr Leu Pro 
        115                 120                 125             

Ile Leu Asp Glu Arg Val Lys Leu Thr Met Ile Ala Gly Ala Phe Ser 
    130                 135                 140                 

Thr Tyr Arg Ala Ser Tyr Tyr Ser Met Pro His Cys Leu Cys Gln Cys 
145                 150                 155                 160 

Met Pro Glu Met Met Arg Phe Gly Glu Met Ser Asp Val Val Ala Leu 
                165                 170                 175     

His Ala Pro Arg Pro Val Leu Leu Ile Asn Gly Ile Asp Asp Lys Ile 
            180                 185                 190         

<210>   313
<211>   193
<212>   PRT
<213>   Blastopirellula marina DSM 3645

<400>   313
Pro Ala Ile Ile Cys Leu His Gly His Ser Gly Ile Asp Pro Tyr Ile 
                5                   10                  15      

Arg Leu Asn Glu Asp Glu Lys Gln Lys Lys Lys Thr Asp Glu Ser Ala 
            20                  25                  30          

Leu Asp Tyr Ala Val Tyr Met Ala Glu His Gly Tyr Val Thr Ala Ala 
        35                  40                  45              

Met Val Val Arg Gly Trp Asn Glu Thr Cys Gly Arg Arg Asp Ala Gly 
    50                  55                  60                  

Tyr Lys Ser Thr His Leu Arg Ser Cys His Glu Met Ser Met Asn Ala 
65                  70                  75                  80  

Phe Leu Met Gly Met Thr Pro Gln Gly Ile Arg Cys Trp Asp Ala Met 
                85                  90                  95      

Arg Val Val Asp Phe Leu Gln Ser Arg Glu Glu Val Asp Pro Asp Lys 
            100                 105                 110         

Ile Gly Val Gly Gly Leu Ser Gly Gly Gly Thr Leu Thr Met Tyr Leu 
        115                 120                 125             

Pro Ile Leu Asp Glu Arg Ile Lys Leu Ala Met Ile Ala Gly Ala Phe 
    130                 135                 140                 

Ser Glu Tyr Arg Thr Ser Ile Phe Ser Ile His His Cys Ile Cys Asn 
145                 150                 155                 160 

Cys Leu Pro Gly Val Met Arg His Gly Glu Met Ala Asp Val Val Ala 
                165                 170                 175     

Leu Phe Ala Pro Arg Pro Val Leu Leu Ile Asn Gly Ile Asp Asp Pro 
            180                 185                 190         

Ile 
    

<210>   314
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   314
Met Met Lys Glu Gly Ser Pro Val Pro Arg Gly Ala Ser Asn Glu Arg 
                5                   10                  15      

Val Glu Ala Leu Val Arg Leu Leu Gly Leu Glu Pro Ser Glu Lys Pro 
            20                  25                  30          

Arg Ser Leu Ser Glu Leu Val Ala Asp Arg Glu Val His Val Leu Leu 
        35                  40                  45              

Pro Glu Gly Thr Ala Pro Ala Gly Gly Tyr Pro Thr Ala Val Leu Ile 
    50                  55                  60                  

His Gly His Ser Pro Leu Gly Tyr Asp Tyr Phe Arg Ser Ala Asn Glu 
65                  70                  75                  80  

Val Tyr Val Lys Gly Ala Pro Val Ala Glu Leu Leu Arg Asp Ala Gly 
                85                  90                  95      

Phe Ala Val Val Leu Pro Ser Leu Arg Gly Phe Gly Ala Thr Met Asp 
            100                 105                 110         

Pro Val Asp Arg Ala Leu Gly Leu Glu His Ser Cys Glu Arg Phe Ala 
        115                 120                 125             

Arg Gln Arg Leu Leu Val Gly Arg Thr Leu Leu Gly Asp Arg Val Arg 
    130                 135                 140                 

Asp Leu Met Glu Leu Leu Asp Ala Met Glu Met Asp Gly Arg Phe Asp 
145                 150                 155                 160 

Ile Glu Ser Leu Val Thr Ala Gly Phe Ser Gly Gly Gly Thr Ala Ala 
                165                 170                 175     

Leu Phe His Ala Ala Cys Asp Ser Arg Val Arg His Leu Leu Leu Leu 
            180                 185                 190         

Ser Ala Leu Cys Thr Ala Arg His Ser Leu Leu Ala Thr Arg His Cys 
        195                 200                 205             

Leu Cys Asn Tyr Val Pro Gly Leu Leu Asn Phe Gly Asp Trp Gly Asp 
    210                 215                 220                 

Val Ala Ala Leu Val Ala Pro Arg Arg Leu Thr Ile Val His Gly Glu 
225                 230                 235                 240 

Arg Asp Gly Val Phe Pro Phe Glu Gly Ala Arg Ala Ala Phe Ala Ala 
                245                 250                 255     

Val Glu Ala Ala Tyr Glu Ala Val Gly Met Thr Lys Arg Ala Met Phe 
            260                 265                 270         

Leu Ala Gln Pro Gly Gly His Glu Pro Tyr Pro Glu Val Leu Trp Gln 
        275                 280                 285             

Leu Met Gly Val Gly Leu Lys Arg Ala Thr Thr 
    290                 295                 

<210>   315
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   315
Met Met Lys Glu Gly Ser Pro Val Pro Arg Gly Ala Ser Asn Glu Arg 
                5                   10                  15      

Val Glu Ala Leu Val Arg Leu Leu Gly Leu Glu Pro Ser Glu Lys Pro 
            20                  25                  30          

Arg Ser Leu Ser Glu Leu Val Ala Asp Arg Glu Val His Val Leu Leu 
        35                  40                  45              

Pro Glu Gly Thr Ala Pro Ala Gly Gly Tyr Pro Thr Ala Val Leu Leu 
    50                  55                  60                  

His Gly His Ser Pro Leu Gly Tyr Asp Tyr Phe Arg Ser Ala Asn Glu 
65                  70                  75                  80  

Val Tyr Val Lys Gly Ala Pro Val Ala Glu Leu Leu Arg Asp Ala Gly 
                85                  90                  95      

Phe Ala Val Val Leu Pro Ser Leu Arg Gly Phe Gly Ala Thr Met Asp 
            100                 105                 110         

Pro Val Asp Arg Ala Leu Gly Leu Glu His Ser Cys Glu Arg Phe Ala 
        115                 120                 125             

Arg Gln Arg Leu Leu Val Gly Arg Thr Leu Leu Gly Asp Arg Val Arg 
    130                 135                 140                 

Asp Leu Met Glu Leu Leu Asp Ala Met Glu Met Asp Gly Arg Phe Asp 
145                 150                 155                 160 

Ile Glu Ser Leu Val Thr Ala Gly Phe Ser Gly Gly Gly Thr Ala Ala 
                165                 170                 175     

Leu Phe His Ala Ala Cys Asp Ser Arg Val Arg His Leu Ile Leu Leu 
            180                 185                 190         

Ser Ala Leu Cys Thr Ala Arg His Ser Leu Leu Ala Thr Arg His Cys 
        195                 200                 205             

Leu Cys Asn Tyr Val Pro Gly Leu Leu Asn Phe Gly Asp Trp Gly Asp 
    210                 215                 220                 

Val Ala Ala Leu Val Ala Pro Arg Arg Leu Thr Ile Val His Gly Glu 
225                 230                 235                 240 

Arg Asp Gly Val Phe Pro Phe Glu Gly Ala Arg Ala Ala Phe Ala Ala 
                245                 250                 255     

Val Glu Ala Ala Tyr Glu Ala Val Gly Met Thr Lys Arg Ala Met Phe 
            260                 265                 270         

Leu Ala Gln Pro Gly Gly His Glu Pro Tyr Pro Glu Val Leu Trp Gln 
        275                 280                 285             

Leu Met Gly Val Gly Leu Lys Arg Ala Thr Thr 
    290                 295                 

<210>   316
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   316
Met Met Lys Glu Gly Ser Pro Val Pro Arg Gly Ala Ser Asn Glu Arg 
                5                   10                  15      

Val Glu Ala Leu Val Arg Leu Leu Gly Leu Glu Pro Ser Glu Lys Pro 
            20                  25                  30          

Arg Ser Leu Ser Glu Leu Val Ala Asp Arg Glu Val His Val Leu Leu 
        35                  40                  45              

Pro Glu Gly Thr Ala Pro Ala Gly Gly Tyr Pro Thr Ala Val Leu Ile 
    50                  55                  60                  

His Gly His Ser Pro Leu Gly Tyr Asp Tyr Phe Arg Ser Ala Asn Glu 
65                  70                  75                  80  

Val Tyr Val Lys Gly Ala Pro Val Ala Glu Leu Leu Arg Asp Ala Gly 
                85                  90                  95      

Phe Ala Val Val Leu Pro Ser Leu Arg Gly Phe Gly Ala Thr Met Asp 
            100                 105                 110         

Pro Val Asp Arg Ala Leu Gly Leu Glu His Ser Cys Glu Arg Phe Ala 
        115                 120                 125             

Arg Gln Arg Leu Leu Val Gly Arg Thr Leu Leu Gly Asp Arg Val Arg 
    130                 135                 140                 

Asp Leu Met Glu Leu Leu Asp Ala Met Glu Met Asp Gly Arg Phe Asp 
145                 150                 155                 160 

Ile Glu Ser Leu Val Thr Ala Gly Phe Ser Gly Gly Gly Thr Ala Ala 
                165                 170                 175     

Leu Phe His Ala Ala Cys Asp Ser Arg Val Arg His Leu Ile Leu Leu 
            180                 185                 190         

Ser Ala Leu Cys Thr Ala Arg His Ser Leu Leu Ala Thr Arg His Cys 
        195                 200                 205             

Leu Cys Asn Tyr Val Pro Gly Leu Leu Asn Phe Gly Asp Trp Gly Asp 
    210                 215                 220                 

Val Ala Ala Leu Val Ala Pro Arg Arg Leu Thr Ile Val His Gly Glu 
225                 230                 235                 240 

Arg Asp Gly Val Phe Pro Phe Glu Gly Ala Arg Ala Ala Phe Ala Ala 
                245                 250                 255     

Val Glu Ala Ala Tyr Glu Ala Val Gly Met Thr Lys Arg Ala Met Phe 
            260                 265                 270         

Leu Ala Gln Pro Gly Gly His Glu Pro Tyr Pro Glu Val Leu Trp Gln 
        275                 280                 285             

Leu Met Gly Val Gly Leu Lys Lys Ala Thr Thr 
    290                 295                 

<210>   317
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   317
Met Met Lys Glu Gly Ser Pro Val Pro Arg Gly Ala Ser Asn Glu Arg 
                5                   10                  15      

Val Glu Ala Leu Val Arg Leu Leu Gly Leu Glu Pro Ser Glu Lys Pro 
            20                  25                  30          

Lys Ser Leu Ser Glu Leu Val Ala Asp Arg Glu Val His Val Leu Leu 
        35                  40                  45              

Pro Glu Gly Thr Ala Pro Ala Gly Gly Tyr Pro Thr Ala Val Leu Ile 
    50                  55                  60                  

His Gly His Ser Pro Leu Gly Tyr Asp Tyr Phe Arg Ser Ala Asn Glu 
65                  70                  75                  80  

Val Tyr Val Lys Gly Ala Pro Val Ala Glu Leu Leu Arg Asp Ala Gly 
                85                  90                  95      

Phe Ala Val Val Leu Pro Ser Leu Arg Gly Phe Gly Ala Thr Met Asp 
            100                 105                 110         

Pro Val Asp Arg Ala Leu Gly Leu Glu His Ser Cys Glu Arg Phe Ala 
        115                 120                 125             

Arg Gln Arg Leu Leu Val Gly Arg Thr Leu Leu Gly Asp Arg Val Arg 
    130                 135                 140                 

Asp Leu Met Glu Leu Leu Asp Ala Met Glu Met Asp Gly Arg Phe Asp 
145                 150                 155                 160 

Ile Glu Ser Leu Val Thr Ala Gly Phe Ser Gly Gly Gly Thr Ala Ala 
                165                 170                 175     

Leu Phe His Ala Ala Cys Asp Ser Arg Val Arg His Leu Ile Leu Leu 
            180                 185                 190         

Ser Ala Leu Cys Thr Ala Arg His Ser Leu Leu Ala Thr Arg His Cys 
        195                 200                 205             

Leu Cys Asn Tyr Val Pro Gly Leu Leu Asn Phe Gly Asp Trp Gly Asp 
    210                 215                 220                 

Val Ala Ala Leu Val Ala Pro Arg Arg Leu Thr Ile Val His Gly Glu 
225                 230                 235                 240 

Arg Asp Gly Val Phe Pro Phe Glu Gly Ala Arg Ala Ala Phe Ala Ala 
                245                 250                 255     

Val Glu Ala Ala Tyr Glu Ala Val Gly Met Thr Lys Arg Ala Met Phe 
            260                 265                 270         

Leu Ala Gln Pro Gly Gly His Glu Pro Tyr Pro Glu Val Leu Trp Gln 
        275                 280                 285             

Leu Met Gly Val Gly Leu Lys Arg Ala Thr Thr 
    290                 295                 

<210>   318
<211>   299
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 307

<400>   318
Met Met Lys Glu Gly Ser Pro Val Pro Arg Gly Ala Ser Asn Glu Arg 
                5                   10                  15      

Val Glu Ala Leu Val Arg Leu Leu Gly Leu Glu Pro Ser Glu Lys Pro 
            20                  25                  30          

Arg Ser Leu Ser Glu Leu Val Ala Asp Arg Glu Val His Val Leu Leu 
        35                  40                  45              

Pro Glu Gly Thr Ala Pro Ala Gly Gly Tyr Pro Thr Ala Val Leu Ile 
    50                  55                  60                  

His Gly His Ser Pro Leu Gly Tyr Asp Tyr Phe Arg Ser Ala Asn Glu 
65                  70                  75                  80  

Val Tyr Val Lys Gly Ala Pro Val Ala Glu Leu Leu Arg Asp Ala Gly 
                85                  90                  95      

Phe Ala Val Val Leu Pro Ser Leu Arg Gly Phe Gly Ala Thr Met Asp 
            100                 105                 110         

Pro Val Asp Arg Ala Leu Gly Leu Glu His Ser Cys Glu Arg Phe Ala 
        115                 120                 125             

Arg Gln Arg Leu Leu Val Gly Arg Thr Leu Leu Gly Asp Arg Val Arg 
    130                 135                 140                 

Asp Leu Met Glu Leu Leu Asp Ala Met Glu Met Asp Gly Arg Phe Asp 
145                 150                 155                 160 

Ile Glu Ser Leu Val Thr Ala Gly Phe Ser Gly Gly Gly Thr Ala Ala 
                165                 170                 175     

Leu Phe His Ala Ala Cys Asp Ser Arg Val Arg His Leu Ile Leu Leu 
            180                 185                 190         

Ser Ala Leu Cys Thr Ala Arg His Ser Leu Leu Ala Thr Arg His Cys 
        195                 200                 205             

Leu Cys Asn Tyr Val Pro Gly Leu Leu Asn Phe Gly Asp Trp Gly Asp 
    210                 215                 220                 

Val Ala Ala Leu Val Ala Pro Arg Arg Leu Thr Ile Val His Gly Glu 
225                 230                 235                 240 

Arg Asp Gly Val Phe Pro Phe Glu Gly Ala Arg Ala Ala Phe Ala Ala 
                245                 250                 255     

Val Glu Ala Ala Tyr Glu Ala Val Gly Met Thr Arg Arg Ala Met Phe 
            260                 265                 270         

Leu Ala Gln Pro Gly Gly His Glu Pro Tyr Pro Glu Val Leu Trp Gln 
        275                 280                 285             

Leu Met Gly Val Gly Leu Lys Arg Ala Thr Thr 
    290                 295                 

<210>   319
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   319
gtgatgaagg agggaagccc ggtgccgcga ggggcgtcga acgaacgagt ggaggccctc       60

gttcggctgc tcggcctgga gccctcggag aagccgagat ccttgagcga actcgtggcg      120

gatcgcgaag tccacgtgct ccttccggag ggcacggcgc ccgcgggcgg ctatcccacc      180

gccgtgttga tccacggcca ttcgccgctc ggctacgatt actttcgcag cgcgaacgag      240

gtgtacgtca agggcgcacc cgtggcggag cttttgcgcg acgcgggctt tgcggtggtg      300

ctcccgtctt tgcgcgggtt tggcgccacg atggacccgg tcgatcgcgc cctgggcctg      360

gagcacagct gtgagcggtt cgcgcggcag cgactgctcg tcggccggac gctcctcggc      420

gatcgcgtcc gcgatctgat ggaactcctg gatgcgatgg agatggacgg ccgcttcgac      480

atagagagcc ttgtcacggc gggattttca ggcggcggca cggccgcgct gtttcacgcg      540

gcctgcgatt cgcgggtccg ccacctgtta ctgctgtcgg cgttgtgcac cgcccggcat      600

tcgctccttg ctacgcggca ctgcctgtgc aactacgtac cgggtcttct gaacttcggc      660

gattgggggg atgtggcggc gctcgtggcg ccgcggcgcc tgaccattgt gcatggcgaa      720

cgcgacggcg tgtttccgtt cgagggtgcg cgtgcagcgt ttgcagcggt cgaagcggcg      780

tacgaggccg tgggtatgac aaagcgtgcg atgtttcttg cacaacctgg gggtcatgag      840

ccgtatccgg aggttttgtg gcagttgatg ggtgtcggtc tcaagcgtgc gacaacgtga      900

                                                                       900


<210>   320
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   320
gtgatgaagg agggaagccc ggtgccgcga ggggcgtcga acgaacgagt ggaggccctc       60

gttcggctgc tcggcctgga gccctcggag aagccgagat ccttgagcga actcgtggcg      120

gatcgcgaag tccacgtgct ccttccggag ggcacggcgc ccgcgggcgg ctatcccacc      180

gccgtgttgt tacacggcca ttcgccgctc ggctacgatt actttcgcag cgcgaacgag      240

gtgtacgtca agggcgcacc cgtggcggag cttttgcgcg acgcgggctt tgcggtggtg      300

ctcccgtctt tgcgcgggtt tggcgccacg atggacccgg tcgatcgcgc cctgggcctg      360

gagcacagct gtgagcggtt cgcgcggcag cgactgctcg tcggccggac gctcctcggc      420

gatcgcgtcc gcgatctgat ggaactcctg gatgcgatgg agatggacgg ccgcttcgac      480

atagagagcc ttgtcacggc gggattttca ggcggcggca cggccgcgct gtttcacgcg      540

gcctgcgatt cgcgggtccg ccacctgatc ctgctgtcgg cgttgtgcac cgcccggcat      600

tcgctccttg ctacgcggca ctgcctgtgc aactacgtac cgggtcttct gaacttcggc      660

gattgggggg atgtggcggc gctcgtggcg ccgcggcgcc tgaccattgt gcatggcgaa      720

cgcgacggcg tgtttccgtt cgagggtgcg cgtgcagcgt ttgcagcggt cgaagcggcg      780

tacgaggccg tgggtatgac aaagcgtgcg atgtttcttg cacaacctgg gggtcatgag      840

ccgtatccgg aggttttgtg gcagttgatg ggtgtcggtc tcaagcgtgc gacaacgtga      900

                                                                       900


<210>   321
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   321
gtgatgaagg agggaagccc ggtgccgcga ggggcgtcga acgaacgagt ggaggccctc       60

gttcggctgc tcggcctgga gccctcggag aagccgagat ccttgagcga actcgtggcg      120

gatcgcgaag tccacgtgct ccttccggag ggcacggcgc ccgcgggcgg ctatcccacc      180

gccgtgttga tccacggcca ttcgccgctc ggctacgatt actttcgcag cgcgaacgag      240

gtgtacgtca agggcgcacc cgtggcggag cttttgcgcg acgcgggctt tgcggtggtg      300

ctcccgtctt tgcgcgggtt tggcgccacg atggacccgg tcgatcgcgc cctgggcctg      360

gagcacagct gtgagcggtt cgcgcggcag cgactgctcg tcggccggac gctcctcggc      420

gatcgcgtcc gcgatctgat ggaactcctg gatgcgatgg agatggacgg ccgcttcgac      480

atagagagcc ttgtcacggc gggattttca ggcggcggca cggccgcgct gtttcacgcg      540

gcctgcgatt cgcgggtccg ccacctgatc ctgctgtcgg cgttgtgcac cgcccggcat      600

tcgctccttg ctacgcggca ctgcctgtgc aactacgtac cgggtcttct gaacttcggc      660

gattgggggg atgtggcggc gctcgtggcg ccgcggcgcc tgaccattgt gcatggcgaa      720

cgcgacggcg tgtttccgtt cgagggtgcg cgtgcagcgt ttgcagcggt cgaagcggcg      780

tacgaggccg tgggtatgac aaagcgtgcg atgtttcttg cacaacctgg gggtcatgag      840

ccgtatccgg aggttttgtg gcagttgatg ggtgtcggtc tcaagaaagc gacaacgtga      900

                                                                       900


<210>   322
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   322
gtgatgaagg agggaagccc ggtgccgcga ggggcgtcga acgaacgagt ggaggccctc       60

gttcggctgc tcggcctgga gccctcggag aagccgaaat ccttgagcga actcgtggcg      120

gatcgcgaag tccacgtgct ccttccggag ggcacggcgc ccgcgggcgg ctatcccacc      180

gccgtgttga tccacggcca ttcgccgctc ggctacgatt actttcgcag cgcgaacgag      240

gtgtacgtca agggcgcacc cgtggcggag cttttgcgcg acgcgggctt tgcggtggtg      300

ctcccgtctt tgcgcgggtt tggcgccacg atggacccgg tcgatcgcgc cctgggcctg      360

gagcacagct gtgagcggtt cgcgcggcag cgactgctcg tcggccggac gctcctcggc      420

gatcgcgtcc gcgatctgat ggaactcctg gatgcgatgg agatggacgg ccgcttcgac      480

atagagagcc ttgtcacggc gggattttca ggcggcggca cggccgcgct gtttcacgcg      540

gcctgcgatt cgcgggtccg ccacctgatc ctgctgtcgg cgttgtgcac cgcccggcat      600

tcgctccttg ctacgcggca ctgcctgtgc aactacgtac cgggtcttct gaacttcggc      660

gattgggggg atgtggcggc gctcgtggcg ccgcggcgcc tgaccattgt gcatggcgaa      720

cgcgacggcg tgtttccgtt cgagggtgcg cgtgcagcgt ttgcagcggt cgaagcggcg      780

tacgaggccg tgggtatgac aaagcgtgcg atgtttcttg cacaacctgg gggtcatgag      840

ccgtatccgg aggttttgtg gcagttgatg ggtgtcggtc tcaagcgtgc gacaacgtga      900

                                                                       900


<210>   323
<211>   900
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 308

<400>   323
gtgatgaagg agggaagccc ggtgccgcga ggggcgtcga acgaacgagt ggaggccctc       60

gttcggctgc tcggcctgga gccctcggag aagccgagat ccttgagcga actcgtggcg      120

gatcgcgaag tccacgtgct ccttccggag ggcacggcgc ccgcgggcgg ctatcccacc      180

gccgtgttga tccacggcca ttcgccgctc ggctacgatt actttcgcag cgcgaacgag      240

gtgtacgtca agggcgcacc cgtggcggag cttttgcgcg acgcgggctt tgcggtggtg      300

ctcccgtctt tgcgcgggtt tggcgccacg atggacccgg tcgatcgcgc cctgggcctg      360

gagcacagct gtgagcggtt cgcgcggcag cgactgctcg tcggccggac gctcctcggc      420

gatcgcgtcc gcgatctgat ggaactcctg gatgcgatgg agatggacgg ccgcttcgac      480

atagagagcc ttgtcacggc gggattttca ggcggcggca cggccgcgct gtttcacgcg      540

gcctgcgatt cgcgggtccg ccacctgatc ctgctgtcgg cgttgtgcac cgcccggcat      600

tcgctccttg ctacgcggca ctgcctgtgc aactacgtac cgggtcttct gaacttcggc      660

gattgggggg atgtggcggc gctcgtggcg ccgcggcgcc tgaccattgt gcatggcgaa      720

cgcgacggcg tgtttccgtt cgagggtgcg cgtgcagcgt ttgcagcggt cgaagcggcg      780

tacgaggccg tgggtatgac acgtcgtgcg atgtttcttg cacaacctgg gggtcatgag      840

ccgtatccgg aggttttgtg gcagttgatg ggtgtcggtc tcaagcgtgc gacaacgtga      900

                                                                       900


<210>   324
<211>   442
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   324
Met Ala Thr Arg Phe Arg Trp Val Ile Ile Gly Leu Leu Phe Phe Ile 
                5                   10                  15      

Thr Val Val Asn Tyr Ile Asp Arg Ser Ala Ile Ser Tyr Ala Ile Gly 
            20                  25                  30          

Asp Ile Ala Gln Val Leu His Leu Asn Asp Ser Gln Val Gly Met Ile 
        35                  40                  45              

Leu Gly Ala Phe Gly Ile Gly Tyr Met Ile Thr Thr Phe Phe Gly Gly 
    50                  55                  60                  

Ile Trp Val Asp His Val Gly Ala Arg Trp Ala Leu Phe Phe Ala Ser 
65                  70                  75                  80  

Leu Leu Trp Ser Leu Ser Ile Gly Leu Thr Gly Val Ala Ala Ser Phe 
                85                  90                  95      

Thr Val Ile Tyr Leu Met Arg Ile Leu Leu Gly Val Ala Glu Gly Pro 
            100                 105                 110         

Asn Phe Pro Ala Val Asn Arg Ala Val Gly Asp Trp Leu Ser Pro Arg 
        115                 120                 125             

Glu Arg Ala Ile Ala Leu Ser Asn Ser Leu Val Ala Val Pro Leu Ala 
    130                 135                 140                 

Leu Ala Ile Gly Ala Pro Ile Val Thr Ser Leu Ile Leu Gly Val Gly 
145                 150                 155                 160 

Trp Arg Gly Met Phe Ile Ile Leu Gly Ile Val Gly Leu Leu Trp Val 
                165                 170                 175     

Pro Val Trp Phe Phe Leu Phe Arg Asp Phe Pro Glu His Ser Arg His 
            180                 185                 190         

Val Asn Asp Glu Glu Leu Arg His Ile Arg Ala Ser Glu His Val Asp 
        195                 200                 205             

Arg Thr Arg Pro Ala Lys Glu Met Arg Phe Arg Gln Ala His His Val 
    210                 215                 220                 

Ser Ser Gly Thr Leu Trp Lys Tyr Leu Leu Val Asn Arg Thr Leu Met 
225                 230                 235                 240 

Ala Asn Asn Trp Ser Phe Phe Val Phe Gly Tyr Tyr Leu Phe Phe Phe 
                245                 250                 255     

Met Thr Trp Leu Pro Ser Tyr Leu Lys Ser Glu Tyr His Leu Asn Leu 
            260                 265                 270         

Lys Ser Val Gly Ala Phe Ser Ile Leu Pro Trp Ala Leu Ala Thr Val 
        275                 280                 285             

Leu Leu Trp Leu Val Gly Tyr Leu Ser Asp Trp Ile Leu Arg Arg Thr 
    290                 295                 300                 

Gly Ser Leu Arg Leu Ala Arg Ser Tyr Pro Ile Trp Ile Ser Gln Leu 
305                 310                 315                 320 

Leu Ser Ala Leu Cys Val Val Pro Leu Thr Phe Thr His Asp Leu Thr 
                325                 330                 335     

Thr Ala Ile Val Phe Ile Thr Leu Ala Val Gly Phe Gly Met Ser Ala 
            340                 345                 350         

Asn Ser Thr Phe Tyr Ala Met Asn Val Asp Leu Met Arg Glu Arg Thr 
        355                 360                 365             

Gly Thr Ala Leu Gly Leu Met Asp Thr Phe Phe Ala Ala Ala Gly Phe 
    370                 375                 380                 

Leu Ala Pro Val Ile Thr Gly Trp Ile Val Asn Ala Thr Gly Ser Phe 
385                 390                 395                 400 

Lys Ser Ala Phe Trp Leu Met Ala Val Leu Ser Ala Thr Ser Val Leu 
                405                 410                 415     

Ala Val Leu Ile Phe His Gln Pro Asp Lys Gln Arg Arg Ile Glu Ser 
            420                 425                 430         

Ala Val Ala Pro Ser Ser Asn Leu Thr His 
        435                 440         

<210>   325
<211>   1329
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   325
atggccacgc gctttcgctg ggtcatcatt ggtcttttgt ttttcatcac ggtggtcaac       60

tacatcgacc gatccgccat ctcgtacgcc atcggcgaca tcgcgcaggt tctgcacctg      120

aacgacagcc aggtgggcat gatcctcggc gcctttggca tcggttacat gatcaccacg      180

tttttcggcg gcatctgggt cgatcacgtc ggcgcccgat gggccctgtt ctttgcgtcg      240

ctcttgtgga gcctgtccat cggactgacg ggcgtcgcag cgtcgttcac cgtcatctac      300

ctcatgcgca tccttctcgg tgtggcggaa gggccgaact tcccagccgt caaccgggcg      360

gtcggcgact ggctgtcgcc tcgcgagcga gccatcgcgc tgtccaactc gctcgtggcc      420

gtcccactcg cgctcgccat cggcgccccg attgtgacgt ccttgattct cggtgtcggc      480

tggcgaggca tgtttatcat cctcggcatt gtgggccttc tctgggtacc cgtctggttc      540

ttcttgttcc gcgattttcc ggagcatagc cgccacgtga acgacgagga actgcgccac      600

atccgcgcat ccgaacatgt ggatcgcacg cggccggcca aggagatgcg ctttcgccag      660

gcgcatcacg tgtcgtccgg cacgctgtgg aagtacctct tggtcaaccg caccttaatg      720

gcgaacaact ggtcgttctt cgtcttcggc tattatctct tcttcttcat gacgtggttg      780

ccatcctatc tgaagagcga atatcacctg aacctgaagt cggtcggcgc cttctccatc      840

ttgccgtggg cgcttgccac cgtgctgttg tggctcgtgg gttatctctc ggactggatc      900

ctgcgccgaa caggcagcct gcgcctggcg agatcgtacc ccatctggat ctcgcaactg      960

ctgtcggcgc tgtgcgtcgt gccgctcacc tttacgcacg acctcacgac ggccatcgtg     1020

ttcatcacgc tcgcggtggg ctttggcatg agcgccaact cgaccttcta cgccatgaac     1080

gtggacctca tgcgagagcg gacgggcacc gcgctcggct tgatggacac gttcttcgca     1140

gccgccggtt tccttgcgcc ggtcatcacg ggatggattg tgaacgcgac gggaagcttc     1200

aagagcgcct tctggctcat ggccgtgctc tcggcgacgt ccgtcctcgc cgtcctcatc     1260

ttccatcagc cggacaaaca gcgccgaatc gaaagcgcag tggccccctc ttcaaacctc     1320

acgcactga                                                             1329


<210>   326
<211>   417
<212>   PRT
<213>   Azorhizobium caulinodans ORS 571

<400>   326
Thr Arg Tyr Arg Trp Phe Val Ile Phe Leu Leu Phe Ala Ile Thr Val 
                5                   10                  15      

Val Asn Tyr Ile Asp Arg Ala Ala Ile Ala Tyr Ala Ile Thr Ala Met 
            20                  25                  30          

Glu Arg Asp Leu Gly Leu Ser Pro Ala Ala Ala Gly Ser Ile Leu Gly 
        35                  40                  45              

Ala Phe Gly Val Gly Tyr Ala Ile Thr Thr Leu Leu Gly Gly Phe Ala 
    50                  55                  60                  

Val Asp Arg Tyr Gly Ala Arg Leu Val Leu Thr Ile Ser Ala Val Leu 
65                  70                  75                  80  

Trp Ser Leu Ser Ile Gly Gly Thr Ala Met Ala Thr Gly Phe Ala Ser 
                85                  90                  95      

Leu Tyr Ala Ala Arg Val Leu Leu Gly Val Ser Glu Gly Pro Asn Phe 
            100                 105                 110         

Pro Ala Leu Thr Gly Ala Val Ser Arg Trp Leu Ala Pro Asn Glu Arg 
        115                 120                 125             

Ala Thr Ala Leu Gly Asn Ala Leu Val Ala Val Pro Val Ala Leu Ala 
    130                 135                 140                 

Ile Gly Gly Pro Ile Val Thr Gln Leu Leu Ala His Leu Asp Trp Arg 
145                 150                 155                 160 

Thr Ala Phe Gly Val Leu Phe Ala Leu Ser Ile Met Trp Val Pro Leu 
                165                 170                 175     

Trp Leu Val Phe Phe Arg Asn Arg Pro Glu Asp Ser Arg Phe Val Asn 
            180                 185                 190         

Ala Ala Glu Leu Ala His Ile Arg Thr Pro Asp Ala Thr Gly Pro Ala 
        195                 200                 205             

Lys Pro Ala Ala Gly His Gly Pro Gly Leu Ala Arg Leu Leu Leu Thr 
    210                 215                 220                 

Asn Pro Thr Leu Val Ser Asn Tyr Trp Ala Phe Phe Val Phe Gly Tyr 
225                 230                 235                 240 

Phe Leu Phe Phe Phe Met Thr Trp Leu Pro Ser Tyr Leu Glu Gln Ala 
                245                 250                 255     

Tyr His Leu Asn Leu Lys Gln Val Gly Leu Phe Thr Val Leu Pro Trp 
            260                 265                 270         

Leu Ala Ala Ala Val Ala Leu Trp Ser Met Gly Arg Trp Ser Asp His 
        275                 280                 285             

Leu Leu Arg Thr Thr Gly Arg Leu Arg Val Ala Arg Ser Tyr Leu Ile 
    290                 295                 300                 

Ala Gly Ser Gln Leu Val Ala Ala Leu Ala Ile Val Pro Val Ala Leu 
305                 310                 315                 320 

Thr Asp Asn Leu Ala Val Ala Ile Thr Gly Ile Thr Val Ala Val Ala 
                325                 330                 335     

Ala Ser Met Gly Ser Asn Ala Ala Tyr Tyr Ala Val Asn Val Asp Val 
            340                 345                 350         

Val Pro Glu Arg Ala Ala Ser Ala Leu Gly Ile Met Asp Phe Ala Phe 
        355                 360                 365             

Ala Leu Ala Gly Phe Leu Ala Pro Ala Ile Thr Gly Trp Val Leu Ala 
    370                 375                 380                 

Leu Arg Gly Ser Phe Thr Asp Gly Phe Ala Leu Met Ala Ala Leu Ala 
385                 390                 395                 400 

Leu Ser Ser Val Val Val Val Leu Leu Phe His His Pro Asp Arg His 
                405                 410                 415     

Arg 
    

<210>   327
<211>   425
<212>   PRT
<213>   Sagittula stellata E-37

<400>   327
Ser His Tyr Arg Trp Val Val Val Ala Leu Leu Phe Ala Ile Val Val 
                5                   10                  15      

Ile Asn Tyr Ile Asp Arg Ser Ala Ile Ser Tyr Ala Ile Asp Pro Ile 
            20                  25                  30          

Ser Lys Glu Leu Ser Leu Thr Ala Ser Gln Lys Gly Leu Ile Leu Gly 
        35                  40                  45              

Ala Phe Gly Val Gly Tyr Met Phe Thr Thr Phe Ile Gly Gly Val Leu 
    50                  55                  60                  

Thr Asp Arg Phe Gly Pro Arg Ile Ile Leu Thr Val Ala Val Ile Leu 
65                  70                  75                  80  

Trp Ala Val Ser Ser Ala Leu Thr Ala Val Ala Ser Ser Phe Phe Leu 
                85                  90                  95      

Leu Leu Ala Leu Arg Ala Leu Leu Gly Leu Ala Glu Gly Pro Met Phe 
            100                 105                 110         

Pro Gly Leu Thr Gly Ala Val Ala His Trp Leu Ser Pro Lys Glu Arg 
        115                 120                 125             

Ala Lys Ala Leu Gly Tyr Ser Leu Ala Ala Val Pro Leu Ala Leu Ala 
    130                 135                 140                 

Ile Gly Gly Pro Ile Val Ser Gly Ile Leu Ser Leu Thr Asp Trp Arg 
145                 150                 155                 160 

Ser Leu Tyr Trp Ile Leu Ala Val Gly Ser Leu Val Trp Phe Pro Leu 
                165                 170                 175     

Trp Phe Trp Met Phe Arg Asn Arg Pro Glu Asp Ser Ala His Val Asn 
            180                 185                 190         

Glu Ala Glu Leu Ala Gln Ile Arg His Lys Asp Ile Glu Val Ile Asp 
        195                 200                 205             

Thr Gly Arg Gly Thr Gly Glu Val Val Pro Ala Arg Ser Asp Asn Ala 
    210                 215                 220                 

Thr Ala Thr Thr Trp Lys Arg Leu Phe Thr Asn Pro Thr Leu Leu Ala 
225                 230                 235                 240 

Asn Tyr Trp Ala Phe Phe Val Phe Gly Tyr Phe Leu Phe Phe Phe Met 
                245                 250                 255     

Thr Trp Leu Pro Gly Phe Leu Glu Gln Lys Phe Ser Val Ser Val Ala 
            260                 265                 270         

Asn Val Gly Trp Phe Ser Phe Val Pro Trp Ala Val Ala Gly Val Val 
        275                 280                 285             

Leu Leu Leu Leu Gly Asn Leu Ser Asp Gly Leu Leu Glu Lys Thr Gln 
    290                 295                 300                 

Ser Leu Arg Ile Ser Arg Ser Trp Phe Ile Ile Val Thr Gln Leu Ile 
305                 310                 315                 320 

Ala Ala Val Val Ile Val Pro Val Ala Phe Thr Ser Thr Leu Trp Val 
                325                 330                 335     

Ala Leu Ala Leu Ile Thr Val Ala Leu Ala Ser Ser Met Gly Ala Asn 
            340                 345                 350         

Ala Val Tyr Tyr Ala Ile Asn Val Asp Ile Ala Pro Asp Arg Ser Ala 
        355                 360                 365             

Thr Ala Leu Gly Leu Met Asp Leu Phe Phe Ala Val Ser Gly Phe Ala 
    370                 375                 380                 

Ala Pro Ala Ile Thr Gly Trp Val Val Gly Ser Ser Gly Ser Phe Thr 
385                 390                 395                 400 

Arg Ala Phe Phe Ile Leu Ala Ala Leu Ala Gly Ser Ser Val Val Leu 
                405                 410                 415     

Thr Phe Leu Phe His Arg Pro Asp Arg 
            420                 425 

<210>   328
<211>   413
<212>   PRT
<213>   Serratia proteamaculans 568

<400>   328
Met Phe Lys Asn Leu Arg Trp Thr Ile Val Phe Leu Leu Phe Met Val 
                5                   10                  15      

Tyr Met Ile Asn Tyr Leu Asp Arg Val Ala Leu Ser Ile Thr Val Pro 
            20                  25                  30          

Met Ile Glu Lys Asp Leu Met Leu Asn Ala Glu Gln Phe Gly Ile Ile 
        35                  40                  45              

Phe Gly Ser Phe Phe Phe Gly Tyr Ala Ile Phe Asn Phe Ile Gly Gly 
    50                  55                  60                  

Leu Ala Val Asp Lys Phe Gly Pro Thr Leu Val Leu Gly Ile Ala Val 
65                  70                  75                  80  

Gly Leu Trp Ser Ile Phe Cys Gly Met Thr Ala Leu Ala Thr Gly Phe 
                85                  90                  95      

Tyr Ser Met Leu Ile Leu Arg Val Leu Phe Gly Met Ala Glu Gly Pro 
            100                 105                 110         

Ile Cys Ala Ser Ala Asn Lys Met Ile Asn Gly Trp Phe Pro Lys Lys 
        115                 120                 125             

Gln Ala Ala Thr Ala Met Gly Leu Leu Ser Ala Gly Ser Pro Leu Gly 
    130                 135                 140                 

Gly Ala Val Ala Gly Pro Ile Val Gly Tyr Leu Ala Leu Ala Phe Gly 
145                 150                 155                 160 

Trp Arg Pro Ala Phe Met Ile Ile Cys Ser Ile Gly Ile Val Trp Met 
                165                 170                 175     

Leu Val Trp Phe Phe Val Val Ala Asp Asn Pro Ala Lys Ser Lys Arg 
            180                 185                 190         

Val Ser Asp Lys Glu Leu Ala Leu Ile Asn Gln Met Lys Glu Glu Thr 
        195                 200                 205             

His Ser Ala Glu Glu Glu Leu Ser Asn Ala Ala His Gly Leu Gly Tyr 
    210                 215                 220                 

Tyr Leu Lys Gln Pro Ile Ile Leu Val Thr Ala Phe Ala Phe Phe Cys 
225                 230                 235                 240 

Tyr Asn Tyr Ile Leu Phe Phe Phe Leu Ser Trp Phe Pro Ser Tyr Leu 
                245                 250                 255     

Val Gln Ala His Asn Leu Asn Ile Lys Glu Met Ser Leu Thr Thr Met 
            260                 265                 270         

Ile Pro Trp Ile Val Gly Phe Val Gly Leu Ala Leu Gly Gly Tyr Ile 
        275                 280                 285             

Ser Asp Lys Ile Phe Asn Ile Thr Gly Lys Leu Leu Leu Ser Arg Lys 
    290                 295                 300                 

Ile Val Leu Val Thr Ser Leu Leu Ala Ala Ala Val Cys Val Ala Leu 
305                 310                 315                 320 

Ala Gly Thr Val Ser Ser Val Val Pro Ala Val Met Leu Met Ser Val 
                325                 330                 335     

Ser Ile Phe Phe Leu Tyr Ile Thr Gly Ala Ile Tyr Trp Ala Ile Ile 
            340                 345                 350         

Gln Asp Val Val His Lys Ser Arg Val Gly Gly Ala Ser Gly Phe Ile 
        355                 360                 365             

His Leu Val Gly Ser Val Ser Gly Ile Ile Gly Pro Val Val Thr Gly 
    370                 375                 380                 

Tyr Ile Val Gln Asn Thr Gly Lys Phe Asp Ser Ala Phe Met Leu Ala 
385                 390                 395                 400 

Gly Gly Val Ala Ala Leu Gly Ala Val Leu Val Leu Leu 
                405                 410             

<210>   329
<211>   420
<212>   PRT
<213>   Burkholderia multivorans ATCC 17616

<400>   329
Met Lys Thr Arg Tyr Arg Trp Trp Val Gly Ala Leu Leu Phe Gly Ala 
                5                   10                  15      

Gly Met Leu Asn Tyr Leu Asp Arg Ala Ala Leu Ser Val Val Ala Pro 
            20                  25                  30          

Ile Ile Lys Arg Asp Leu Gly Ile Ser Asp Ala Gln Met Gly Val Leu 
        35                  40                  45              

Phe Ser Ser Phe Phe Val Gly Tyr Cys Val Phe Cys Phe Val Gly Gly 
    50                  55                  60                  

Trp Ala Ala Asp Arg Phe Gly Pro Arg Arg Val Phe Ala Trp Ala Ala 
65                  70                  75                  80  

Gly Val Trp Ser Leu Phe Cys Gly Ala Thr Ala Leu Ala Gly Ser Phe 
                85                  90                  95      

Val His Leu Leu Val Val Arg Val Ala Phe Gly Ile Gly Glu Gly Pro 
            100                 105                 110         

Met Gly Thr Thr Thr Asn Lys Ala Ile Ser Asn Trp Phe Pro Arg Arg 
        115                 120                 125             

Glu Ala Gly Arg Ala Val Gly Trp Thr Asn Ala Gly Gln Pro Leu Gly 
    130                 135                 140                 

Ala Ala Ile Ala Ala Pro Ile Val Gly Leu Val Ala Leu Gln Phe Gly 
145                 150                 155                 160 

Trp Arg Val Ser Phe Val Val Ile Ala Ala Leu Gly Phe Leu Trp Leu 
                165                 170                 175     

Val Ala Trp Trp Arg Leu Phe Arg Asp Glu Pro Ala Ala His Pro Arg 
            180                 185                 190         

Val Ser Leu Glu Glu Ala Arg Glu Ile Ala Ala Asp Arg Gly Val Asp 
        195                 200                 205             

Ala Val His Gly Thr Arg Asp Val His Ala Ala Asp Ala His Ala Ala 
    210                 215                 220                 

Arg Pro Leu Leu His Tyr Leu Leu Ser Arg Pro Val Leu Gly Val Ala 
225                 230                 235                 240 

Leu Ala Phe Phe Ser Phe Asn Tyr Val Leu Tyr Phe Phe Leu Ser Trp 
                245                 250                 255     

Leu Pro Ser Tyr Leu Thr Asp Tyr Gln His Leu Asn Ile Lys Gln Met 
            260                 265                 270         

Ser Val Val Gly Ile Leu Pro Trp Leu Gly Ala Thr Val Gly Phe Val 
        275                 280                 285             

Ala Gly Gly Thr Val Ser Asp Arg Ile Tyr Arg His Ser Gly Asp Val 
    290                 295                 300                 

Leu Phe Ala Arg Lys Ile Val Ile Val Val Gly Leu Gly Val Ala Ala 
305                 310                 315                 320 

Ala Cys Val Leu Leu Ala Ser Arg Val Asn Ser Leu Gly Ala Ala Val 
                325                 330                 335     

Thr Leu Ile Ala Ile Ala Ser Leu Phe Ala Phe Met Ala Pro Gln Ala 
            340                 345                 350         

Cys Trp Ser Leu Leu Gln Glu Ile Val Pro Arg Glu Arg Val Gly Ala 
        355                 360                 365             

Ala Gly Gly Phe Val His Leu Leu Ala Asn Leu Ala Gly Ile Leu Ser 
    370                 375                 380                 

Pro Ser Leu Thr Gly Trp Leu Val Gln Tyr Gly Gly Gly Tyr Ala Gly 
385                 390                 395                 400 

Ala Phe Val Leu Ala Gly Ala Ser Ala Leu Ala Gly Ala Ala Ile Leu 
                405                 410                 415     

Thr Val Ala Val 
            420 

<210>   330
<211>   432
<212>   PRT
<213>   Bacillus anthracis str. Ames

<400>   330
Met Lys Asn Lys Phe Arg Tyr Tyr Val Phe Thr Met Leu Thr Phe Ile 
                5                   10                  15      

Thr Ile Val Asn Tyr Ile Asp Arg Gly Ala Ile Ala Tyr Ala Gln Ser 
            20                  25                  30          

Phe Ile Ile Lys Glu Tyr Gly Phe Asp Pro Lys Glu Trp Gly Ala Ile 
        35                  40                  45              

Leu Gly Tyr Phe Gly Tyr Gly Tyr Met Ile Gly Ser Leu Leu Gly Gly 
    50                  55                  60                  

Ile Phe Ser Asp Lys Lys Gly Pro Lys Phe Val Trp Ile Val Ala Ala 
65                  70                  75                  80  

Thr Ala Trp Ser Ile Phe Glu Ile Ala Thr Ala Phe Ala Gly Glu Ile 
                85                  90                  95      

Gly Ile Ala Val Phe Gly Gly Ser Ala Leu Ile Gly Phe Ala Ile Phe 
            100                 105                 110         

Arg Val Leu Phe Gly Leu Thr Glu Gly Pro Ser Phe Ala Val Ser Asn 
        115                 120                 125             

Lys Thr Ala Ala Asn Trp Ala Ala Pro Lys Glu Arg Ala Phe Leu Thr 
    130                 135                 140                 

Ser Leu Gly Phe Val Gly Val Pro Leu Gly Ala Val Leu Thr Ala Pro 
145                 150                 155                 160 

Val Ala Val Leu Leu Leu Ser Phe Thr Ser Trp Lys Ile Met Phe Phe 
                165                 170                 175     

Ile Leu Gly Thr Ile Gly Ile Val Trp Ala Ile Ile Trp Tyr Phe Thr 
            180                 185                 190         

Phe Thr Asn Met Pro Glu Asp His Pro Arg Val Thr Lys Glu Glu Leu 
        195                 200                 205             

Ala Glu Ile Arg Ser Thr Glu Gly Val Leu Gln Ser Ala Lys Val Glu 
    210                 215                 220                 

Lys Glu Ile Pro Lys Glu Pro Trp Tyr Ser Phe Phe Lys Val Pro Thr 
225                 230                 235                 240 

Phe Val Met Val Thr Ile Ala Tyr Phe Cys Phe Gln Tyr Ile Asn Phe 
                245                 250                 255     

Leu Ile Leu Thr Trp Thr Pro Lys Tyr Leu Gln Asp Val Phe His Phe 
            260                 265                 270         

Gln Leu Ser Ser Leu Trp Tyr Leu Gly Met Ile Pro Trp Leu Gly Ala 
        275                 280                 285             

Cys Ile Thr Leu Pro Leu Gly Ala Lys Leu Ser Asp Arg Ile Leu Arg 
    290                 295                 300                 

Lys Thr Gly Asn Leu Arg Leu Ala Arg Thr Gly Leu Pro Ile Ile Ala 
305                 310                 315                 320 

Leu Leu Leu Thr Ala Ile Cys Phe Ser Phe Ile Pro Ala Met Asn Asn 
                325                 330                 335     

Tyr Val Ala Val Leu Ala Leu Met Ser Leu Gly Asn Ala Phe Ala Phe 
            340                 345                 350         

Leu Pro Ser Ser Leu Phe Trp Ala Ile Ile Val Asp Thr Ala Pro Ala 
        355                 360                 365             

Tyr Ser Gly Thr Tyr Ser Gly Ile Met His Phe Ile Ala Asn Ile Ala 
    370                 375                 380                 

Thr Ile Leu Ala Pro Thr Leu Thr Gly Tyr Leu Val Val Ser Tyr Gly 
385                 390                 395                 400 

Tyr Pro Ser Met Phe Ile Val Ala Ala Ile Leu Ala Ala Ile Ala Met 
                405                 410                 415     

Gly Ala Met Leu Phe Val Lys Pro Gly Gln Gln Thr Lys Thr Glu Ser 
            420                 425                 430         

<210>   331
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   331
Met Ala Thr Arg Phe Arg Trp Val Ile Ile Gly Leu Leu Phe Phe Ile 
                5                   10                  15      

Thr Val Val Asn Tyr Ile Asp Arg Ser Ala Ile Ser Tyr Ala Ile Gly 
            20                  25                  30          

Asp Ile Ala Gln Val Leu His Leu Asn Asp Ser Gln Val Gly Met Ile 
        35                  40                  45              

Leu Gly Ala Phe Gly Ile Gly Tyr Met Ile Thr Thr Phe Phe Gly Gly 
    50                  55                  60                  

Ile Trp Val Asp His Val Gly Ala Arg Trp Ala Leu Phe Phe Ala Ser 
65                  70                  75                  80  

Leu Leu Trp Ser Leu Ser Ile Gly Leu Thr Gly Val Ala Ala Ser Phe 
                85                  90                  95      

Thr Val Ile Tyr Leu Met Arg Ile Leu Leu Gly Val Ala Glu Gly Pro 
            100                 105                 110         

Asn Phe Pro Ala Val Asn Arg Ala Val Gly Asp Trp Leu Ser Pro Arg 
        115                 120                 125             

Glu Arg Ala Ile Ala Leu Ser Asn Ser Leu Val Ala Val Pro Leu Ala 
    130                 135                 140                 

Leu Ala Ile Gly Ala Pro Ile Val Thr Ser Leu Ile Leu Gly Val Gly 
145                 150                 155                 160 

Trp Arg Gly Met Phe Ile Ile Leu Gly Ile Val Gly Leu Leu Trp Val 
                165                 170                 175     

Pro Val Trp Phe Phe Leu Phe Arg Asp Phe Pro Glu His Ser Arg His 
            180                 185                 190         

Val Asn Asp Glu Glu Leu Arg His Ile Arg Ala Ser Glu His Val Asp 
        195                 200                 205             

Arg Thr Arg Pro Ala Lys Glu Met Arg Phe Arg Gln Ala His His Val 
    210                 215                 220                 

Ser Ser Gly Thr Leu Trp Lys Tyr Leu Leu Val Asn Arg Thr Leu Met 
225                 230                 235                 240 

Ala Asn Asn Trp Ser Phe Phe Val Phe Gly Tyr Tyr Leu Phe Phe Phe 
                245                 250                 255     

Met Thr Trp Leu Pro Ser Tyr Leu Lys Ser Glu Tyr His Leu Asn Leu 
            260                 265                 270         

Lys Ser Val Gly Ala Phe Ser Ile Leu Pro Trp Ala Leu Ala Thr Val 
        275                 280                 285             

Leu Leu Trp Leu Val Gly Tyr Leu Ser Asp Trp Ile Leu Arg Arg Thr 
    290                 295                 300                 

Gly Ser Leu Arg Leu Ala Arg Ser Tyr Pro Ile Trp Ile Ser Gln Leu 
305                 310                 315                 320 

Leu Ser Ala Leu Cys Val Val Pro Leu Thr Phe Thr His Asp Leu Thr 
                325                 330                 335     

Thr Ala Ile Val Phe Ile Thr Leu Ala Val Gly Phe Gly Met Ser Ala 
            340                 345                 350         

Asn Ser Thr Phe Tyr Ala Met Asn Val Asp Leu Met Arg Glu Arg Thr 
        355                 360                 365             

Gly Thr Ala Leu Gly Leu Met Asp Thr Phe Phe Ala Ala Ala Gly Phe 
    370                 375                 380                 

Leu Ala Pro Val Ile Thr Gly Trp Ile Val Asn Ala Thr Gly Ser Phe 
385                 390                 395                 400 

Lys Ser Ala Phe Trp Leu Met Ala Val Leu Ser Ala Thr Ser Val Leu 
                405                 410                 415     

Ala Val Leu Ile Phe His Gln Pro Asp Lys Gln Arg Arg Ile Asp Ser 
            420                 425                 430         

Ala Val Ala Pro Ser Ser Asn Leu Thr His 
        435                 440         

<210>   332
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   332
Met Ala Thr Arg Phe Arg Trp Val Ile Ile Gly Leu Leu Phe Phe Ile 
                5                   10                  15      

Thr Val Val Asn Tyr Ile Asp Arg Ser Ala Ile Ser Tyr Ala Ile Gly 
            20                  25                  30          

Asp Ile Ala Gln Val Leu His Leu Asn Asp Ser Gln Val Gly Met Ile 
        35                  40                  45              

Leu Gly Ala Phe Gly Ile Gly Tyr Met Ile Thr Thr Phe Phe Gly Gly 
    50                  55                  60                  

Ile Trp Val Asp His Val Gly Ala Arg Trp Ala Leu Phe Phe Ala Ser 
65                  70                  75                  80  

Leu Leu Trp Ser Leu Ser Ile Gly Leu Thr Gly Val Ala Ala Ser Phe 
                85                  90                  95      

Thr Val Leu Tyr Leu Met Arg Ile Leu Leu Gly Val Ala Glu Gly Pro 
            100                 105                 110         

Asn Phe Pro Ala Val Asn Arg Ala Val Gly Asp Trp Leu Ser Pro Arg 
        115                 120                 125             

Glu Arg Ala Ile Ala Leu Ser Asn Ser Leu Val Ala Val Pro Leu Ala 
    130                 135                 140                 

Leu Ala Ile Gly Ala Pro Ile Val Thr Ser Leu Ile Leu Gly Val Gly 
145                 150                 155                 160 

Trp Arg Gly Met Phe Ile Ile Leu Gly Ile Val Gly Leu Leu Trp Val 
                165                 170                 175     

Pro Val Trp Phe Phe Leu Phe Arg Asp Phe Pro Glu His Ser Arg His 
            180                 185                 190         

Val Asn Asp Glu Glu Leu Arg His Ile Arg Ala Ser Glu His Val Asp 
        195                 200                 205             

Arg Thr Arg Pro Ala Lys Glu Met Arg Phe Arg Gln Ala His His Val 
    210                 215                 220                 

Ser Ser Gly Thr Leu Trp Lys Tyr Leu Leu Val Asn Arg Thr Leu Met 
225                 230                 235                 240 

Ala Asn Asn Trp Ser Phe Phe Val Phe Gly Tyr Tyr Leu Phe Phe Phe 
                245                 250                 255     

Met Thr Trp Leu Pro Ser Tyr Leu Lys Ser Glu Tyr His Leu Asn Leu 
            260                 265                 270         

Lys Ser Val Gly Ala Phe Ser Ile Leu Pro Trp Ala Leu Ala Thr Val 
        275                 280                 285             

Leu Leu Trp Leu Val Gly Tyr Leu Ser Asp Trp Ile Leu Arg Arg Thr 
    290                 295                 300                 

Gly Ser Leu Arg Leu Ala Arg Ser Tyr Pro Ile Trp Ile Ser Gln Leu 
305                 310                 315                 320 

Leu Ser Ala Leu Cys Val Val Pro Leu Thr Phe Thr His Asp Leu Thr 
                325                 330                 335     

Thr Ala Ile Val Phe Ile Thr Leu Ala Val Gly Phe Gly Met Ser Ala 
            340                 345                 350         

Asn Ser Thr Phe Tyr Ala Met Asn Val Asp Leu Met Arg Glu Arg Thr 
        355                 360                 365             

Gly Thr Ala Leu Gly Leu Met Asp Thr Phe Phe Ala Ala Ala Gly Phe 
    370                 375                 380                 

Leu Ala Pro Val Ile Thr Gly Trp Ile Val Asn Ala Thr Gly Ser Phe 
385                 390                 395                 400 

Lys Ser Ala Phe Trp Leu Met Ala Val Leu Ser Ala Thr Ser Val Leu 
                405                 410                 415     

Ala Val Leu Ile Phe His Gln Pro Asp Lys Gln Arg Arg Ile Glu Ser 
            420                 425                 430         

Ala Val Ala Pro Ser Ser Asn Leu Thr His 
        435                 440         

<210>   333
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   333
Met Ala Thr Arg Phe Arg Trp Val Ile Ile Gly Leu Leu Phe Phe Ile 
                5                   10                  15      

Thr Val Val Asn Tyr Ile Asp Arg Ser Ala Ile Ser Tyr Ala Ile Gly 
            20                  25                  30          

Asp Ile Ala Gln Val Leu His Leu Asn Asp Ser Gln Val Gly Met Ile 
        35                  40                  45              

Leu Gly Ala Phe Gly Ile Gly Tyr Met Ile Thr Thr Phe Phe Gly Gly 
    50                  55                  60                  

Ile Trp Val Asp His Val Gly Ala Arg Trp Ala Leu Phe Phe Ala Ser 
65                  70                  75                  80  

Leu Leu Trp Ser Leu Ser Ile Gly Leu Thr Gly Val Ala Ala Ser Phe 
                85                  90                  95      

Thr Val Ile Tyr Leu Met Arg Ile Leu Leu Gly Val Ala Glu Gly Pro 
            100                 105                 110         

Asn Phe Pro Ala Val Asn Arg Ala Val Gly Asp Trp Leu Ser Pro Arg 
        115                 120                 125             

Glu Arg Ala Ile Ala Leu Ser Asn Ser Leu Val Ala Val Pro Leu Ala 
    130                 135                 140                 

Leu Ala Ile Gly Ala Pro Ile Val Thr Ser Leu Ile Leu Gly Val Gly 
145                 150                 155                 160 

Trp Arg Gly Met Phe Ile Ile Leu Gly Ile Val Gly Leu Leu Trp Val 
                165                 170                 175     

Pro Val Trp Phe Phe Leu Phe Arg Asp Phe Pro Glu His Ser Arg His 
            180                 185                 190         

Val Asn Asp Glu Glu Leu Arg His Ile Arg Ala Ser Glu His Val Asp 
        195                 200                 205             

Arg Thr Arg Pro Ala Lys Glu Met Arg Phe Arg Gln Ala His His Val 
    210                 215                 220                 

Ser Ser Gly Thr Leu Trp Lys Tyr Leu Leu Val Asn Arg Thr Leu Met 
225                 230                 235                 240 

Ala Asn Asn Trp Ser Phe Phe Val Phe Gly Tyr Tyr Leu Phe Phe Phe 
                245                 250                 255     

Met Thr Trp Leu Pro Ser Tyr Leu Lys Ser Glu Tyr His Leu Asn Leu 
            260                 265                 270         

Lys Ser Val Gly Ala Phe Ser Ile Leu Pro Trp Ala Leu Ala Thr Val 
        275                 280                 285             

Leu Leu Trp Leu Val Gly Tyr Leu Ser Asp Trp Ile Leu Arg Arg Thr 
    290                 295                 300                 

Gly Ser Leu Arg Leu Ala Arg Ser Tyr Pro Ile Trp Ile Ser Gln Leu 
305                 310                 315                 320 

Leu Ser Ala Leu Cys Val Val Pro Leu Thr Phe Thr His Glu Leu Thr 
                325                 330                 335     

Thr Ala Ile Val Phe Ile Thr Leu Ala Val Gly Phe Gly Met Ser Ala 
            340                 345                 350         

Asn Ser Thr Phe Tyr Ala Met Asn Val Asp Leu Met Arg Glu Arg Thr 
        355                 360                 365             

Gly Thr Ala Leu Gly Leu Met Asp Thr Phe Phe Ala Ala Ala Gly Phe 
    370                 375                 380                 

Leu Ala Pro Val Ile Thr Gly Trp Ile Val Asn Ala Thr Gly Ser Phe 
385                 390                 395                 400 

Lys Ser Ala Phe Trp Leu Met Ala Val Leu Ser Ala Thr Ser Val Leu 
                405                 410                 415     

Ala Val Leu Ile Phe His Gln Pro Asp Lys Gln Arg Arg Ile Glu Ser 
            420                 425                 430         

Ala Val Ala Pro Ser Ser Asn Leu Thr His 
        435                 440         

<210>   334
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   334
Met Ala Thr Arg Phe Arg Trp Val Ile Ile Gly Leu Leu Phe Phe Ile 
                5                   10                  15      

Thr Val Val Asn Tyr Ile Asp Arg Ser Ala Ile Ser Tyr Ala Ile Gly 
            20                  25                  30          

Asp Ile Ala Gln Val Leu His Leu Asn Asp Ser Gln Val Gly Met Ile 
        35                  40                  45              

Leu Gly Ala Phe Gly Ile Gly Tyr Met Ile Thr Thr Phe Phe Gly Gly 
    50                  55                  60                  

Ile Trp Val Asp His Val Gly Ala Arg Trp Ala Leu Phe Phe Ala Ser 
65                  70                  75                  80  

Leu Leu Trp Ser Leu Ser Ile Gly Leu Thr Gly Val Ala Ala Ser Phe 
                85                  90                  95      

Thr Val Ile Tyr Leu Met Arg Ile Leu Leu Gly Val Ala Glu Gly Pro 
            100                 105                 110         

Asn Phe Pro Ala Val Asn Arg Ala Val Gly Asp Trp Leu Ser Pro Arg 
        115                 120                 125             

Glu Arg Ala Ile Ala Leu Ser Asn Ser Leu Val Ala Val Pro Leu Ala 
    130                 135                 140                 

Leu Ala Ile Gly Ala Pro Ile Val Thr Ser Leu Ile Leu Gly Val Gly 
145                 150                 155                 160 

Trp Arg Gly Met Phe Ile Ile Leu Gly Ile Val Gly Leu Leu Trp Val 
                165                 170                 175     

Pro Val Trp Phe Phe Leu Phe Arg Asp Phe Pro Glu His Ser Arg His 
            180                 185                 190         

Val Asn Asp Glu Glu Leu Arg His Ile Arg Ala Ser Glu His Val Asp 
        195                 200                 205             

Arg Thr Arg Pro Ala Lys Glu Met Arg Phe Arg Asn Ala His His Val 
    210                 215                 220                 

Ser Ser Gly Thr Leu Trp Lys Tyr Leu Leu Val Asn Arg Thr Leu Met 
225                 230                 235                 240 

Ala Asn Asn Trp Ser Phe Phe Val Phe Gly Tyr Tyr Leu Phe Phe Phe 
                245                 250                 255     

Met Thr Trp Leu Pro Ser Tyr Leu Lys Ser Glu Tyr His Leu Asn Leu 
            260                 265                 270         

Lys Ser Val Gly Ala Phe Ser Ile Leu Pro Trp Ala Leu Ala Thr Val 
        275                 280                 285             

Leu Leu Trp Leu Val Gly Tyr Leu Ser Asp Trp Ile Leu Arg Arg Thr 
    290                 295                 300                 

Gly Ser Leu Arg Leu Ala Arg Ser Tyr Pro Ile Trp Ile Ser Gln Leu 
305                 310                 315                 320 

Leu Ser Ala Leu Cys Val Val Pro Leu Thr Phe Thr His Asp Leu Thr 
                325                 330                 335     

Thr Ala Ile Val Phe Ile Thr Leu Ala Val Gly Phe Gly Met Ser Ala 
            340                 345                 350         

Asn Ser Thr Phe Tyr Ala Met Asn Val Asp Leu Met Arg Glu Arg Thr 
        355                 360                 365             

Gly Thr Ala Leu Gly Leu Met Asp Thr Phe Phe Ala Ala Ala Gly Phe 
    370                 375                 380                 

Leu Ala Pro Val Ile Thr Gly Trp Ile Val Asn Ala Thr Gly Ser Phe 
385                 390                 395                 400 

Lys Ser Ala Phe Trp Leu Met Ala Val Leu Ser Ala Thr Ser Val Leu 
                405                 410                 415     

Ala Val Leu Ile Phe His Gln Pro Asp Lys Gln Arg Arg Ile Glu Ser 
            420                 425                 430         

Ala Val Ala Pro Ser Ser Asn Leu Thr His 
        435                 440         

<210>   335
<211>   442
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 324

<400>   335
Met Ala Thr Arg Phe Arg Trp Val Ile Ile Gly Leu Leu Phe Phe Ile 
                5                   10                  15      

Thr Val Val Asn Tyr Ile Asp Arg Ser Ala Ile Ser Tyr Ala Ile Gly 
            20                  25                  30          

Asp Ile Ala Gln Val Leu His Leu Asn Asp Ser Gln Val Gly Met Ile 
        35                  40                  45              

Leu Gly Ala Phe Gly Ile Gly Tyr Met Ile Thr Thr Phe Phe Gly Gly 
    50                  55                  60                  

Ile Trp Val Asp His Val Gly Ala Arg Trp Ala Leu Phe Phe Ala Ser 
65                  70                  75                  80  

Leu Leu Trp Ser Leu Ser Ile Gly Leu Thr Gly Val Ala Ala Ser Phe 
                85                  90                  95      

Thr Val Ile Tyr Leu Met Arg Ile Leu Leu Gly Val Ala Glu Gly Pro 
            100                 105                 110         

Asn Phe Pro Ala Val Asn Arg Ala Val Gly Asp Trp Leu Ser Pro Arg 
        115                 120                 125             

Glu Arg Ala Ile Ala Leu Ser Asn Ser Leu Val Ala Val Pro Leu Ala 
    130                 135                 140                 

Leu Ala Ile Gly Ala Pro Ile Val Thr Ser Leu Ile Leu Gly Val Gly 
145                 150                 155                 160 

Trp Arg Gly Met Phe Ile Ile Leu Gly Ile Val Gly Leu Leu Trp Val 
                165                 170                 175     

Pro Val Trp Phe Phe Leu Phe Arg Asp Phe Pro Glu His Ser Arg His 
            180                 185                 190         

Val Gln Asp Glu Glu Leu Arg His Ile Arg Ala Ser Glu His Val Asp 
        195                 200                 205             

Arg Thr Arg Pro Ala Lys Glu Met Arg Phe Arg Gln Ala His His Val 
    210                 215                 220                 

Ser Ser Gly Thr Leu Trp Lys Tyr Leu Leu Val Asn Arg Thr Leu Met 
225                 230                 235                 240 

Ala Asn Asn Trp Ser Phe Phe Val Phe Gly Tyr Tyr Leu Phe Phe Phe 
                245                 250                 255     

Met Thr Trp Leu Pro Ser Tyr Leu Lys Ser Glu Tyr His Leu Asn Leu 
            260                 265                 270         

Lys Ser Val Gly Ala Phe Ser Ile Leu Pro Trp Ala Leu Ala Thr Val 
        275                 280                 285             

Leu Leu Trp Leu Val Gly Tyr Leu Ser Asp Trp Ile Leu Arg Arg Thr 
    290                 295                 300                 

Gly Ser Leu Arg Leu Ala Arg Ser Tyr Pro Ile Trp Ile Ser Gln Leu 
305                 310                 315                 320 

Leu Ser Ala Leu Cys Val Val Pro Leu Thr Phe Thr His Asp Leu Thr 
                325                 330                 335     

Thr Ala Ile Val Phe Ile Thr Leu Ala Val Gly Phe Gly Met Ser Ala 
            340                 345                 350         

Asn Ser Thr Phe Tyr Ala Met Asn Val Asp Leu Met Arg Glu Arg Thr 
        355                 360                 365             

Gly Thr Ala Leu Gly Leu Met Asp Thr Phe Phe Ala Ala Ala Gly Phe 
    370                 375                 380                 

Leu Ala Pro Val Ile Thr Gly Trp Ile Val Asn Ala Thr Gly Ser Phe 
385                 390                 395                 400 

Lys Ser Ala Phe Trp Leu Met Ala Val Leu Ser Ala Thr Ser Val Leu 
                405                 410                 415     

Ala Val Leu Ile Phe His Gln Pro Asp Lys Gln Arg Arg Ile Glu Ser 
            420                 425                 430         

Ala Val Ala Pro Ser Ser Asn Leu Thr His 
        435                 440         

<210>   336
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   336
atggccacgc gctttcgctg ggtcatcatt ggtcttttgt ttttcatcac ggtggtcaac       60

tacatcgacc gatccgccat ctcgtacgcc atcggcgaca tcgcgcaggt tctgcacctg      120

aacgacagcc aggtgggcat gatcctcggc gcctttggca tcggttacat gatcaccacg      180

tttttcggcg gcatctgggt cgatcacgtc ggcgcccgat gggccctgtt ctttgcgtcg      240

ctcttgtgga gcctgtccat cggactgacg ggcgtcgcag cgtcgttcac cgtcatctac      300

ctcatgcgca tccttctcgg tgtggcggaa gggccgaact tcccagccgt caaccgggcg      360

gtcggcgact ggctgtcgcc tcgcgagcga gccatcgcgc tgtccaactc gctcgtggcc      420

gtcccactcg cgctcgccat cggcgccccg attgtgacgt ccttgattct cggtgtcggc      480

tggcgaggca tgtttatcat cctcggcatt gtgggccttc tctgggtacc cgtctggttc      540

ttcttgttcc gcgattttcc ggagcatagc cgccacgtga acgacgagga actgcgccac      600

atccgcgcat ccgaacatgt ggatcgcacg cggccggcca aggagatgcg ctttcgccag      660

gcgcatcacg tgtcgtccgg cacgctgtgg aagtacctct tggtcaaccg caccttaatg      720

gcgaacaact ggtcgttctt cgtcttcggc tattatctct tcttcttcat gacgtggttg      780

ccatcctatc tgaagagcga atatcacctg aacctgaagt cggtcggcgc cttctccatc      840

ttgccgtggg cgcttgccac cgtgctgttg tggctcgtgg gttatctctc ggactggatc      900

ctgcgccgaa caggcagcct gcgcctggcg agatcgtacc ccatctggat ctcgcaactg      960

ctgtcggcgc tgtgcgtcgt gccgctcacc tttacgcacg acctcacgac ggccatcgtg     1020

ttcatcacgc tcgcggtggg ctttggcatg agcgccaact cgaccttcta cgccatgaac     1080

gtggacctca tgcgagagcg gacgggcacc gcgctcggct tgatggacac gttcttcgca     1140

gccgccggtt tccttgcgcc ggtcatcacg ggatggattg tgaacgcgac gggaagcttc     1200

aagagcgcct tctggctcat ggccgtgctc tcggcgacgt ccgtcctcgc cgtcctcatc     1260

ttccatcagc cggacaaaca gcgccgaatc gatagcgcag tggccccctc ttcaaacctc     1320

acgcactga                                                             1329


<210>   337
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   337
atggccacgc gctttcgctg ggtcatcatt ggtcttttgt ttttcatcac ggtggtcaac       60

tacatcgacc gatccgccat ctcgtacgcc atcggcgaca tcgcgcaggt tctgcacctg      120

aacgacagcc aggtgggcat gatcctcggc gcctttggca tcggttacat gatcaccacg      180

tttttcggcg gcatctgggt cgatcacgtc ggcgcccgat gggccctgtt ctttgcgtcg      240

ctcttgtgga gcctgtccat cggactgacg ggcgtcgcag cgtcgttcac cgtcttatac      300

ctcatgcgca tccttctcgg tgtggcggaa gggccgaact tcccagccgt caaccgggcg      360

gtcggcgact ggctgtcgcc tcgcgagcga gccatcgcgc tgtccaactc gctcgtggcc      420

gtcccactcg cgctcgccat cggcgccccg attgtgacgt ccttgattct cggtgtcggc      480

tggcgaggca tgtttatcat cctcggcatt gtgggccttc tctgggtacc cgtctggttc      540

ttcttgttcc gcgattttcc ggagcatagc cgccacgtga acgacgagga actgcgccac      600

atccgcgcat ccgaacatgt ggatcgcacg cggccggcca aggagatgcg ctttcgccag      660

gcgcatcacg tgtcgtccgg cacgctgtgg aagtacctct tggtcaaccg caccttaatg      720

gcgaacaact ggtcgttctt cgtcttcggc tattatctct tcttcttcat gacgtggttg      780

ccatcctatc tgaagagcga atatcacctg aacctgaagt cggtcggcgc cttctccatc      840

ttgccgtggg cgcttgccac cgtgctgttg tggctcgtgg gttatctctc ggactggatc      900

ctgcgccgaa caggcagcct gcgcctggcg agatcgtacc ccatctggat ctcgcaactg      960

ctgtcggcgc tgtgcgtcgt gccgctcacc tttacgcacg acctcacgac ggccatcgtg     1020

ttcatcacgc tcgcggtggg ctttggcatg agcgccaact cgaccttcta cgccatgaac     1080

gtggacctca tgcgagagcg gacgggcacc gcgctcggct tgatggacac gttcttcgca     1140

gccgccggtt tccttgcgcc ggtcatcacg ggatggattg tgaacgcgac gggaagcttc     1200

aagagcgcct tctggctcat ggccgtgctc tcggcgacgt ccgtcctcgc cgtcctcatc     1260

ttccatcagc cggacaaaca gcgccgaatc gaaagcgcag tggccccctc ttcaaacctc     1320

acgcactga                                                             1329


<210>   338
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   338
atggccacgc gctttcgctg ggtcatcatt ggtcttttgt ttttcatcac ggtggtcaac       60

tacatcgacc gatccgccat ctcgtacgcc atcggcgaca tcgcgcaggt tctgcacctg      120

aacgacagcc aggtgggcat gatcctcggc gcctttggca tcggttacat gatcaccacg      180

tttttcggcg gcatctgggt cgatcacgtc ggcgcccgat gggccctgtt ctttgcgtcg      240

ctcttgtgga gcctgtccat cggactgacg ggcgtcgcag cgtcgttcac cgtcatctac      300

ctcatgcgca tccttctcgg tgtggcggaa gggccgaact tcccagccgt caaccgggcg      360

gtcggcgact ggctgtcgcc tcgcgagcga gccatcgcgc tgtccaactc gctcgtggcc      420

gtcccactcg cgctcgccat cggcgccccg attgtgacgt ccttgattct cggtgtcggc      480

tggcgaggca tgtttatcat cctcggcatt gtgggccttc tctgggtacc cgtctggttc      540

ttcttgttcc gcgattttcc ggagcatagc cgccacgtga acgacgagga actgcgccac      600

atccgcgcat ccgaacatgt ggatcgcacg cggccggcca aggagatgcg ctttcgccag      660

gcgcatcacg tgtcgtccgg cacgctgtgg aagtacctct tggtcaaccg caccttaatg      720

gcgaacaact ggtcgttctt cgtcttcggc tattatctct tcttcttcat gacgtggttg      780

ccatcctatc tgaagagcga atatcacctg aacctgaagt cggtcggcgc cttctccatc      840

ttgccgtggg cgcttgccac cgtgctgttg tggctcgtgg gttatctctc ggactggatc      900

ctgcgccgaa caggcagcct gcgcctggcg agatcgtacc ccatctggat ctcgcaactg      960

ctgtcggcgc tgtgcgtcgt gccgctcacc tttacgcacg aactcacgac ggccatcgtg     1020

ttcatcacgc tcgcggtggg ctttggcatg agcgccaact cgaccttcta cgccatgaac     1080

gtggacctca tgcgagagcg gacgggcacc gcgctcggct tgatggacac gttcttcgca     1140

gccgccggtt tccttgcgcc ggtcatcacg ggatggattg tgaacgcgac gggaagcttc     1200

aagagcgcct tctggctcat ggccgtgctc tcggcgacgt ccgtcctcgc cgtcctcatc     1260

ttccatcagc cggacaaaca gcgccgaatc gaaagcgcag tggccccctc ttcaaacctc     1320

acgcactga                                                             1329


<210>   339
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   339
atggccacgc gctttcgctg ggtcatcatt ggtcttttgt ttttcatcac ggtggtcaac       60

tacatcgacc gatccgccat ctcgtacgcc atcggcgaca tcgcgcaggt tctgcacctg      120

aacgacagcc aggtgggcat gatcctcggc gcctttggca tcggttacat gatcaccacg      180

tttttcggcg gcatctgggt cgatcacgtc ggcgcccgat gggccctgtt ctttgcgtcg      240

ctcttgtgga gcctgtccat cggactgacg ggcgtcgcag cgtcgttcac cgtcatctac      300

ctcatgcgca tccttctcgg tgtggcggaa gggccgaact tcccagccgt caaccgggcg      360

gtcggcgact ggctgtcgcc tcgcgagcga gccatcgcgc tgtccaactc gctcgtggcc      420

gtcccactcg cgctcgccat cggcgccccg attgtgacgt ccttgattct cggtgtcggc      480

tggcgaggca tgtttatcat cctcggcatt gtgggccttc tctgggtacc cgtctggttc      540

ttcttgttcc gcgattttcc ggagcatagc cgccacgtga acgacgagga actgcgccac      600

atccgcgcat ccgaacatgt ggatcgcacg cggccggcca aggagatgcg ctttcgcaat      660

gcgcatcacg tgtcgtccgg cacgctgtgg aagtacctct tggtcaaccg caccttaatg      720

gcgaacaact ggtcgttctt cgtcttcggc tattatctct tcttcttcat gacgtggttg      780

ccatcctatc tgaagagcga atatcacctg aacctgaagt cggtcggcgc cttctccatc      840

ttgccgtggg cgcttgccac cgtgctgttg tggctcgtgg gttatctctc ggactggatc      900

ctgcgccgaa caggcagcct gcgcctggcg agatcgtacc ccatctggat ctcgcaactg      960

ctgtcggcgc tgtgcgtcgt gccgctcacc tttacgcacg acctcacgac ggccatcgtg     1020

ttcatcacgc tcgcggtggg ctttggcatg agcgccaact cgaccttcta cgccatgaac     1080

gtggacctca tgcgagagcg gacgggcacc gcgctcggct tgatggacac gttcttcgca     1140

gccgccggtt tccttgcgcc ggtcatcacg ggatggattg tgaacgcgac gggaagcttc     1200

aagagcgcct tctggctcat ggccgtgctc tcggcgacgt ccgtcctcgc cgtcctcatc     1260

ttccatcagc cggacaaaca gcgccgaatc gaaagcgcag tggccccctc ttcaaacctc     1320

acgcactga                                                             1329


<210>   340
<211>   1329
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 325

<400>   340
atggccacgc gctttcgctg ggtcatcatt ggtcttttgt ttttcatcac ggtggtcaac       60

tacatcgacc gatccgccat ctcgtacgcc atcggcgaca tcgcgcaggt tctgcacctg      120

aacgacagcc aggtgggcat gatcctcggc gcctttggca tcggttacat gatcaccacg      180

tttttcggcg gcatctgggt cgatcacgtc ggcgcccgat gggccctgtt ctttgcgtcg      240

ctcttgtgga gcctgtccat cggactgacg ggcgtcgcag cgtcgttcac cgtcatctac      300

ctcatgcgca tccttctcgg tgtggcggaa gggccgaact tcccagccgt caaccgggcg      360

gtcggcgact ggctgtcgcc tcgcgagcga gccatcgcgc tgtccaactc gctcgtggcc      420

gtcccactcg cgctcgccat cggcgccccg attgtgacgt ccttgattct cggtgtcggc      480

tggcgaggca tgtttatcat cctcggcatt gtgggccttc tctgggtacc cgtctggttc      540

ttcttgttcc gcgattttcc ggagcatagc cgccacgtgc aagacgagga actgcgccac      600

atccgcgcat ccgaacatgt ggatcgcacg cggccggcca aggagatgcg ctttcgccag      660

gcgcatcacg tgtcgtccgg cacgctgtgg aagtacctct tggtcaaccg caccttaatg      720

gcgaacaact ggtcgttctt cgtcttcggc tattatctct tcttcttcat gacgtggttg      780

ccatcctatc tgaagagcga atatcacctg aacctgaagt cggtcggcgc cttctccatc      840

ttgccgtggg cgcttgccac cgtgctgttg tggctcgtgg gttatctctc ggactggatc      900

ctgcgccgaa caggcagcct gcgcctggcg agatcgtacc ccatctggat ctcgcaactg      960

ctgtcggcgc tgtgcgtcgt gccgctcacc tttacgcacg acctcacgac ggccatcgtg     1020

ttcatcacgc tcgcggtggg ctttggcatg agcgccaact cgaccttcta cgccatgaac     1080

gtggacctca tgcgagagcg gacgggcacc gcgctcggct tgatggacac gttcttcgca     1140

gccgccggtt tccttgcgcc ggtcatcacg ggatggattg tgaacgcgac gggaagcttc     1200

aagagcgcct tctggctcat ggccgtgctc tcggcgacgt ccgtcctcgc cgtcctcatc     1260

ttccatcagc cggacaaaca gcgccgaatc gaaagcgcag tggccccctc ttcaaacctc     1320

acgcactga                                                             1329


<210>   341
<211>   309
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   341
Met Thr Trp Phe Arg Arg Tyr Arg Leu Gly Pro Leu Leu Gly Leu Val 
                5                   10                  15      

Leu Leu Ile Leu Ile Leu Ala Val Ala Ser Arg Gln Phe Phe Thr Ala 
            20                  25                  30          

Ser Asn Leu Leu Asp Ile Ala Leu Gln Thr Ser Val Asn Ala Leu Leu 
        35                  40                  45              

Ala Ile Gly Met Thr Phe Val Ile Leu Thr Ala Gly Ile Asp Leu Ser 
    50                  55                  60                  

Val Gly Ser Thr Leu Ala Leu Thr Ser Ala Ile Ala Ala Gln Trp Met 
65                  70                  75                  80  

Val Gly Gly Thr Ser Pro Trp Leu Ala Gly Ile Ser Ala Leu Cys Ile 
                85                  90                  95      

Gly Ala Ile Ala Gly Ala Phe Asn Gly Val Leu Val Ala Tyr Ala Arg 
            100                 105                 110         

Leu Ala Pro Phe Ile Val Thr Leu Gly Thr Met Thr Leu Phe Arg Gly 
        115                 120                 125             

Leu Thr Glu Ile Tyr Thr Asn Gly Gln Pro Ile Phe Asn Leu Pro Tyr 
    130                 135                 140                 

Ser Phe Asn Gly Leu Gly Asn Gly Ala Val Leu Gly Val Pro Val Pro 
145                 150                 155                 160 

Val Trp Ile Thr Met Ile Val Phe Leu Ile Ala Trp Met Val Leu Ser 
                165                 170                 175     

Arg Thr Val Ala Gly Arg Arg Ile Tyr Ala Ile Gly Gly Asn Glu Lys 
            180                 185                 190         

Val Ala Tyr Leu Ala Gly Val Arg Ala Lys Arg Tyr Leu Val Ala Val 
        195                 200                 205             

Tyr Val Val Ser Gly Ile Leu Ala Ala Leu Ala Gly Leu Ile Leu Thr 
    210                 215                 220                 

Ser Arg Leu Ala Thr Ala Glu Pro Thr Ala Gly Gln Gly Tyr Glu Leu 
225                 230                 235                 240 

Asp Ala Ile Thr Ala Val Val Leu Gly Gly Thr Ser Leu Phe Gly Gly 
                245                 250                 255     

Glu Gly Thr Leu Val Gly Thr Ile Ile Gly Ala Leu Ile Leu Gly Val 
            260                 265                 270         

Ile Asp Asn Gly Leu Asn Leu Leu Asn Val Ser Ser Phe Tyr Gln Asp 
        275                 280                 285             

Ala Val Lys Gly Leu Val Ile Leu Ile Ala Ile Met Leu Asp Arg Lys 
    290                 295                 300                 

Arg Ser Glu Gly Arg 
305                 

<210>   342
<211>   930
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   342
atgacttggt ttcgcaggta tcggttgggc cctcttctcg ggttggtttt gctcattctc       60

atcctggctg tagcatctcg gcagttcttc actgcgagta acctgttgga cattgcgttg      120

caaacatccg tgaatgcgct cttggccatc gggatgacgt ttgtgatcct aacggccgga      180

attgacctgt cggtaggatc cacgctggca ctgacatcgg ccatcgcggc acagtggatg      240

gtgggcggta caagtccatg gctggcaggc atatctgcgt tatgcattgg agccatcgcc      300

ggagcgttca atggtgtcct cgtggcctat gcacgtcttg cgcccttcat cgtcacactt      360

ggaacgatga cgttgtttcg tggtttaacc gaaatttata cgaacggtca acccattttt      420

aacctgcctt attcctttaa cgggctcggg aacggggcgg ttctaggagt tcctgtcccc      480

gtctggatca cgatgatcgt gttccttatc gcatggatgg ttctctcgcg cactgtggca      540

ggcagaagga tttatgccat tggaggaaac gagaaagttg cgtacttggc gggggttcgc      600

gccaagcgat atctggtggc ggtctatgtg gtcagtggta ttttagcggc actggctggc      660

ctcattctca cttctcgtct tgcaactgcc gaaccgaccg cagggcaagg ttacgagctc      720

gatgcaatca cggccgtcgt actcggtgga actagtcttt tcggcggtga ggggacttta      780

gtcgggacca tcatcggcgc gctgattctc ggtgtcattg acaacggtct gaacttgtta      840

aatgtaagtt ccttctatca agatgctgtc aagggcctcg ttattctgat cgccatcatg      900

ttggaccgta agagatccga agggagataa                                       930


<210>   343
<211>   284
<212>   PRT
<213>   Desulfotomaculum reducens MI-1

<400>   343
Ser Asp Arg Phe Phe Thr Thr Ser Asn Leu Leu Asn Val Ala Arg Gln 
                5                   10                  15      

Val Ser Ile Asn Thr Leu Leu Gly Val Gly Met Thr Phe Val Ile Leu 
            20                  25                  30          

Thr Gly Gly Ile Asp Leu Ser Val Gly Ser Ile Leu Ala Leu Ala Gly 
        35                  40                  45              

Ala Leu Gly Ala Gly Phe Leu Gly Gln Gly Asn Thr Thr Leu Met Val 
    50                  55                  60                  

Val Leu Tyr Ala Cys Leu Ile Gly Leu Leu Ala Gly Thr Val Asn Gly 
65                  70                  75                  80  

Thr Ile Val Ala Tyr Gly Arg Val Ala Pro Phe Ile Ala Thr Leu Ala 
                85                  90                  95      

Thr Met Thr Leu Phe Arg Gly Ala Thr Leu Ile Tyr Thr Glu Gly Arg 
            100                 105                 110         

Pro Val Arg Ala Val Ala Glu Gly Phe Asn Glu Leu Gly Gly Gly Tyr 
        115                 120                 125             

Leu Gly Ala Ile Pro Thr Pro Val Ile Ile Thr Ser Val Ile Val Leu 
    130                 135                 140                 

Leu Ala Trp Phe Val Leu Thr Gln Met Thr Pro Gly Arg Arg Ile Phe 
145                 150                 155                 160 

Ala Leu Gly Gly Asn Glu Glu Ala Ala Ile Leu Ser Gly Ile Arg Thr 
                165                 170                 175     

Asn His Tyr Lys Ile Met Val Tyr Ser Ile Ser Gly Leu Leu Ala Gly 
            180                 185                 190         

Leu Ala Gly Val Ile Leu Ser Ser Arg Leu Leu Ser Ala Gln Pro Thr 
        195                 200                 205             

Ala Gly Ile Gly Tyr Glu Leu Asp Ala Ile Ala Ala Val Val Ile Gly 
    210                 215                 220                 

Gly Thr Ser Leu Thr Gly Gly Gln Gly Gly Val Ile Gly Thr Leu Ile 
225                 230                 235                 240 

Gly Ala Leu Ile Ile Gly Val Ile Asp Asn Gly Leu Asn Leu Leu Asn 
                245                 250                 255     

Val Ser Ser Phe Tyr Gln Gln Ala Val Lys Gly Leu Ile Ile Leu Val 
            260                 265                 270         

Ala Val Leu Leu Asp Arg Arg Asn Ala Val Gly Arg 
        275                 280                 

<210>   344
<211>   280
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   344
Phe Leu Ser Pro Asn Asn Leu Met Asn Val Leu Arg Gln Val Ser Ile 
                5                   10                  15      

Asn Ala Leu Ile Ala Phe Gly Met Thr Phe Val Ile Leu Thr Gly Gly 
            20                  25                  30          

Ile Asp Leu Ser Val Gly Ser Ile Leu Ala Leu Ser Gly Ala Val Thr 
        35                  40                  45              

Ala Thr Leu Met Ala Ser Gly Val Asp Pro Val Leu Ser Val Leu Ile 
    50                  55                  60                  

Gly Leu Leu Ala Gly Ala Ala Leu Gly Ala Phe Asn Gly Ile Ile Ile 
65                  70                  75                  80  

Ala Lys Gly Lys Val Ala Pro Phe Ile Ala Thr Leu Ala Thr Met Thr 
                85                  90                  95      

Ile Phe Arg Gly Leu Thr Leu Val Phe Thr Asp Gly Arg Pro Val Ser 
            100                 105                 110         

Gly Leu Gly Asp Ser Thr Phe Phe Asp Met Leu Gly Arg Gly Tyr Leu 
        115                 120                 125             

Phe Gly Ile Pro Val Pro Ala Val Thr Met Met Val Ser Phe Leu Val 
    130                 135                 140                 

Leu Tyr Leu Ile Leu Lys Lys Thr Thr Phe Gly Arg Arg Val Tyr Ala 
145                 150                 155                 160 

Val Gly Gly Asn Glu Glu Ala Ala Val Leu Ser Gly Ile Asn Ala Asp 
                165                 170                 175     

Arg Val Lys Ile Tyr Val Tyr Ser Leu Thr Gly Phe Leu Ala Ala Leu 
            180                 185                 190         

Ala Gly Thr Ile Leu Thr Ser Arg Leu Ser Ser Ala Gln Pro Thr Ala 
        195                 200                 205             

Gly Gln Met Tyr Glu Leu Asp Ala Ile Ala Ala Val Val Leu Gly Gly 
    210                 215                 220                 

Thr Ser Leu Thr Gly Gly Arg Gly Trp Ile Val Gly Thr Leu Ile Gly 
225                 230                 235                 240 

Ala Leu Ile Ile Gly Val Leu Asn Asn Gly Leu Asn Leu Leu Gly Val 
                245                 250                 255     

Ser Ser Phe Phe Gln Gln Val Val Lys Gly Ser Val Ile Leu Leu Ala 
            260                 265                 270         

Val Leu Leu Asp Arg Lys Lys Asn 
        275                 280 

<210>   345
<211>   280
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   345
Phe Leu Glu Pro Leu Asn Ile Leu Asn Leu Leu Arg Gln Ile Ser Ile 
                5                   10                  15      

Asn Ala Leu Ile Ala Phe Gly Met Thr Phe Val Ile Leu Thr Gly Gly 
            20                  25                  30          

Ile Asp Leu Ser Val Gly Ala Ile Leu Ala Leu Ser Ser Ala Leu Thr 
        35                  40                  45              

Ala Gly Phe Ile Val Ser Gly Met Asp Pro Ile Leu Ala Ile Ile Val 
    50                  55                  60                  

Gly Ser Ile Ile Gly Ala Ile Leu Gly Met Val Asn Gly Leu Leu Ile 
65                  70                  75                  80  

Thr Lys Gly Lys Met Ala Pro Phe Ile Ala Thr Leu Ala Thr Met Thr 
                85                  90                  95      

Ile Phe Arg Gly Leu Thr Leu Val Tyr Thr Asp Gly Asn Pro Ile Thr 
            100                 105                 110         

Gly Leu Gly Ser Asn Tyr Ala Phe Gln Leu Phe Gly Arg Gly Tyr Phe 
        115                 120                 125             

Leu Gly Ile Pro Val Pro Ala Ile Thr Met Leu Leu Thr Phe Ile Val 
    130                 135                 140                 

Leu Trp Val Leu Leu His Lys Thr Pro Phe Gly Arg Arg Thr Tyr Ala 
145                 150                 155                 160 

Ile Gly Gly Asn Glu Lys Ala Ala Leu Ile Ser Gly Ile Lys Val Pro 
                165                 170                 175     

Arg Val Lys Ile Met Ile Tyr Ser Leu Ala Gly Phe Met Ser Ala Leu 
            180                 185                 190         

Ala Gly Ala Ile Leu Thr Ser Arg Leu Asn Ser Ala Gln Pro Thr Ala 
        195                 200                 205             

Gly Thr Ser Tyr Glu Leu Asp Ala Ile Ala Ala Val Val Leu Gly Gly 
    210                 215                 220                 

Thr Ser Leu Ser Gly Gly Arg Gly Arg Ile Val Gly Thr Leu Ile Gly 
225                 230                 235                 240 

Val Leu Ile Ile Gly Val Leu Asn Asn Gly Met Asn Leu Leu Gly Val 
                245                 250                 255     

Ser Ser Phe Tyr Gln Ser Val Val Lys Gly Ile Val Ile Leu Ile Ala 
            260                 265                 270         

Val Leu Leu Asp Arg Lys Lys Ser 
        275                 280 

<210>   346
<211>   279
<212>   PRT
<213>   Clostridium novyi NT

<400>   346
Ser Pro Arg Phe Leu Thr Val Pro Asn Ile Lys Asn Val Leu Thr Gln 
                5                   10                  15      

Val Ser Val Asn Ala Ile Ile Ala Ile Gly Met Thr Phe Val Ile Leu 
            20                  25                  30          

Thr Gly Gly Ile Asp Leu Ser Val Gly Ser Thr Leu Ala Ile Ser Gly 
        35                  40                  45              

Ala Val Ala Ala Thr Leu Ile Lys Ala Asn Cys Ser Ile Phe Val Ala 
    50                  55                  60                  

Ile Ile Val Ala Ile Ile Val Gly Ile Ile Val Gly Leu Val Asn Gly 
65                  70                  75                  80  

Val Val Ile Ala Lys Gly Lys Ile Gln Ala Phe Ile Ala Thr Leu Ala 
                85                  90                  95      

Thr Met Thr Val Phe Arg Gly Val Thr Gln Val Tyr Thr Asn Gly Thr 
            100                 105                 110         

Pro Val Ser Lys Leu Gly Glu Ala Phe Gly Lys Ile Gly Asn Thr Glu 
        115                 120                 125             

Ile Ile Gly Ile Pro Leu Pro Val Val Ile Thr Ile Ala Val Phe Leu 
    130                 135                 140                 

Val Ala Phe Tyr Val Leu Asn Glu Thr Arg Cys Gly Arg Tyr Ile Tyr 
145                 150                 155                 160 

Ala Leu Gly Gly Asn Glu Asp Ser Ala Arg Leu Ser Gly Ile Asn Thr 
                165                 170                 175     

Thr Lys Met Lys Met Leu Val Tyr Val Ile Ser Gly Val Thr Ala Ala 
            180                 185                 190         

Ile Ser Gly Val Val Val Thr Ser Arg Ile Gly Ser Ala Ser Ala Ile 
        195                 200                 205             

Ala Gly Thr Gly Tyr Glu Leu Asp Ala Ile Ala Ala Val Val Leu Gly 
    210                 215                 220                 

Gly Thr Ser Leu Ala Gly Gly Glu Gly Ser Ile Ala Gly Thr Ile Ile 
225                 230                 235                 240 

Gly Ala Leu Ile Ile Gly Val Leu Asn Asn Gly Leu Asn Leu Leu Asn 
                245                 250                 255     

Val Ser Pro Tyr Tyr Gln Leu Ile Val Lys Gly Leu Val Ile Leu Leu 
            260                 265                 270         

Ala Val Met Val Asp Arg Lys 
        275                 

<210>   347
<211>   280
<212>   PRT
<213>   Oceanobacillus iheyensis HTE831

<400>   347
Phe Leu Asp Pro Ala Asn Ile Met Asn Leu Leu Arg Gln Ile Ser Ile 
                5                   10                  15      

Asn Gly Leu Ile Ala Phe Gly Met Thr Phe Val Ile Leu Thr Gly Gly 
            20                  25                  30          

Ile Asp Leu Ser Val Gly Ser Ile Leu Ala Leu Ser Ser Ala Leu Ala 
        35                  40                  45              

Ala Ile Met Met Thr Ser Gly Ile Asp Pro Ile Leu Ala Val Ile Ile 
    50                  55                  60                  

Gly Val Leu Leu Gly Ala Val Phe Gly Ala Leu Asn Gly Ile Leu Val 
65                  70                  75                  80  

Ser Lys Gly Asn Leu Ala Pro Phe Ile Val Thr Leu Ala Thr Met Thr 
                85                  90                  95      

Ile Phe Arg Gly Leu Thr Leu Val Phe Thr Asp Gly Lys Pro Ile Thr 
            100                 105                 110         

Gly Leu Gly Asp Ser Tyr Ala Phe Gln Leu Phe Gly Lys Gly Tyr Phe 
        115                 120                 125             

Leu Gly Ile Pro Val Pro Ala Val Thr Met Ile Ile Ala Phe Val Ile 
    130                 135                 140                 

Leu Trp Phe Leu Leu His Lys Met Ser Phe Gly Arg Lys Thr Tyr Ala 
145                 150                 155                 160 

Ile Gly Gly Asn Glu Lys Ala Ala Lys Ile Ser Gly Ile Lys Val Asp 
                165                 170                 175     

Arg Val Lys Ile Phe Ile Tyr Ser Ile Ser Gly Met Met Ala Ala Leu 
            180                 185                 190         

Ala Gly Met Ile Leu Thr Ser Arg Leu Asn Ser Ala Gln Pro Thr Ala 
        195                 200                 205             

Gly Thr Ser Tyr Glu Met Asp Ala Ile Ala Ala Val Val Leu Gly Gly 
    210                 215                 220                 

Thr Ser Leu Ala Gly Gly Lys Gly Arg Ile Ala Gly Thr Phe Ile Gly 
225                 230                 235                 240 

Val Leu Ile Ile Gly Ile Leu Asn Asn Gly Met Asn Leu Leu Gly Ile 
                245                 250                 255     

Ser Ser Phe Tyr Gln Gln Val Val Lys Gly Val Val Ile Leu Ile Ala 
            260                 265                 270         

Val Leu Leu Asp Arg Lys Lys Ser 
        275                 280 

<210>   348
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   348
Met Thr Trp Phe Arg Arg Tyr Arg Leu Gly Pro Ile Leu Gly Leu Val 
                5                   10                  15      

Leu Leu Ile Leu Ile Leu Ala Val Ala Ser Arg Gln Phe Phe Thr Ala 
            20                  25                  30          

Ser Asn Leu Leu Asp Ile Ala Leu Gln Thr Ser Val Asn Ala Leu Leu 
        35                  40                  45              

Ala Ile Gly Met Thr Phe Val Ile Leu Thr Ala Gly Ile Asp Leu Ser 
    50                  55                  60                  

Val Gly Ser Thr Leu Ala Leu Thr Ser Ala Ile Ala Ala Gln Trp Met 
65                  70                  75                  80  

Val Gly Gly Thr Ser Pro Trp Leu Ala Gly Ile Ser Ala Leu Cys Ile 
                85                  90                  95      

Gly Ala Ile Ala Gly Ala Phe Asn Gly Val Leu Val Ala Tyr Ala Arg 
            100                 105                 110         

Leu Ala Pro Phe Ile Val Thr Leu Gly Thr Met Thr Leu Phe Arg Gly 
        115                 120                 125             

Leu Thr Glu Ile Tyr Thr Asn Gly Gln Pro Ile Phe Asn Leu Pro Tyr 
    130                 135                 140                 

Ser Phe Asn Gly Leu Gly Asn Gly Ala Val Leu Gly Val Pro Val Pro 
145                 150                 155                 160 

Val Trp Ile Thr Met Ile Val Phe Leu Ile Ala Trp Met Val Leu Ser 
                165                 170                 175     

Arg Thr Val Ala Gly Arg Arg Ile Tyr Ala Ile Gly Gly Asn Glu Lys 
            180                 185                 190         

Val Ala Tyr Leu Ala Gly Val Arg Ala Lys Arg Tyr Leu Val Ala Val 
        195                 200                 205             

Tyr Val Val Ser Gly Ile Leu Ala Ala Leu Ala Gly Leu Ile Leu Thr 
    210                 215                 220                 

Ser Arg Leu Ala Thr Ala Glu Pro Thr Ala Gly Gln Gly Tyr Glu Leu 
225                 230                 235                 240 

Asp Ala Ile Thr Ala Val Val Leu Gly Gly Thr Ser Leu Phe Gly Gly 
                245                 250                 255     

Glu Gly Thr Leu Val Gly Thr Ile Ile Gly Ala Leu Ile Leu Gly Val 
            260                 265                 270         

Ile Asp Asn Gly Leu Asn Leu Leu Asn Val Ser Ser Phe Tyr Gln Asp 
        275                 280                 285             

Ala Val Lys Gly Leu Val Ile Leu Ile Ala Ile Met Leu Asp Arg Lys 
    290                 295                 300                 

Arg Ser Glu Gly Arg 
305                 

<210>   349
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   349
Met Thr Trp Phe Arg Arg Tyr Arg Ile Gly Pro Leu Leu Gly Leu Val 
                5                   10                  15      

Leu Leu Ile Leu Ile Leu Ala Val Ala Ser Arg Gln Phe Phe Thr Ala 
            20                  25                  30          

Ser Asn Leu Leu Asp Ile Ala Leu Gln Thr Ser Val Asn Ala Leu Leu 
        35                  40                  45              

Ala Ile Gly Met Thr Phe Val Ile Leu Thr Ala Gly Ile Asp Leu Ser 
    50                  55                  60                  

Val Gly Ser Thr Leu Ala Leu Thr Ser Ala Ile Ala Ala Gln Trp Met 
65                  70                  75                  80  

Val Gly Gly Thr Ser Pro Trp Leu Ala Gly Ile Ser Ala Leu Cys Ile 
                85                  90                  95      

Gly Ala Ile Ala Gly Ala Phe Asn Gly Val Leu Val Ala Tyr Ala Arg 
            100                 105                 110         

Leu Ala Pro Phe Ile Val Thr Leu Gly Thr Met Thr Leu Phe Arg Gly 
        115                 120                 125             

Leu Thr Glu Ile Tyr Thr Asn Gly Gln Pro Ile Phe Asn Leu Pro Tyr 
    130                 135                 140                 

Ser Phe Asn Gly Leu Gly Asn Gly Ala Val Leu Gly Val Pro Val Pro 
145                 150                 155                 160 

Val Trp Ile Thr Met Ile Val Phe Leu Ile Ala Trp Met Val Leu Ser 
                165                 170                 175     

Arg Thr Val Ala Gly Arg Arg Ile Tyr Ala Ile Gly Gly Asn Glu Lys 
            180                 185                 190         

Val Ala Tyr Leu Ala Gly Val Arg Ala Lys Arg Tyr Leu Val Ala Val 
        195                 200                 205             

Tyr Val Val Ser Gly Ile Leu Ala Ala Leu Ala Gly Leu Ile Leu Thr 
    210                 215                 220                 

Ser Arg Leu Ala Thr Ala Glu Pro Thr Ala Gly Gln Gly Tyr Glu Leu 
225                 230                 235                 240 

Asp Ala Ile Thr Ala Val Val Leu Gly Gly Thr Ser Leu Phe Gly Gly 
                245                 250                 255     

Glu Gly Thr Leu Val Gly Thr Ile Ile Gly Ala Leu Ile Leu Gly Val 
            260                 265                 270         

Ile Asp Asn Gly Leu Asn Leu Leu Asn Val Ser Ser Phe Tyr Gln Asp 
        275                 280                 285             

Ala Val Lys Gly Leu Val Ile Leu Ile Ala Ile Met Leu Asp Arg Lys 
    290                 295                 300                 

Arg Ser Glu Gly Arg 
305                 

<210>   350
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   350
Met Thr Trp Phe Arg Arg Tyr Arg Leu Gly Pro Leu Leu Gly Leu Val 
                5                   10                  15      

Leu Leu Ile Leu Ile Leu Ala Val Ala Ser Arg Gln Phe Phe Thr Ala 
            20                  25                  30          

Ser Asn Leu Leu Asp Ile Ala Ile Gln Thr Ser Val Asn Ala Leu Leu 
        35                  40                  45              

Ala Ile Gly Met Thr Phe Val Ile Leu Thr Ala Gly Ile Asp Leu Ser 
    50                  55                  60                  

Val Gly Ser Thr Leu Ala Leu Thr Ser Ala Ile Ala Ala Gln Trp Met 
65                  70                  75                  80  

Val Gly Gly Thr Ser Pro Trp Leu Ala Gly Ile Ser Ala Leu Cys Ile 
                85                  90                  95      

Gly Ala Ile Ala Gly Ala Phe Asn Gly Val Leu Val Ala Tyr Ala Arg 
            100                 105                 110         

Leu Ala Pro Phe Ile Val Thr Leu Gly Thr Met Thr Leu Phe Arg Gly 
        115                 120                 125             

Leu Thr Glu Ile Tyr Thr Asn Gly Gln Pro Ile Phe Asn Leu Pro Tyr 
    130                 135                 140                 

Ser Phe Asn Gly Leu Gly Asn Gly Ala Val Leu Gly Val Pro Val Pro 
145                 150                 155                 160 

Val Trp Ile Thr Met Ile Val Phe Leu Ile Ala Trp Met Val Leu Ser 
                165                 170                 175     

Arg Thr Val Ala Gly Arg Arg Ile Tyr Ala Ile Gly Gly Asn Glu Lys 
            180                 185                 190         

Val Ala Tyr Leu Ala Gly Val Arg Ala Lys Arg Tyr Leu Val Ala Val 
        195                 200                 205             

Tyr Val Val Ser Gly Ile Leu Ala Ala Leu Ala Gly Leu Ile Leu Thr 
    210                 215                 220                 

Ser Arg Leu Ala Thr Ala Glu Pro Thr Ala Gly Gln Gly Tyr Glu Leu 
225                 230                 235                 240 

Asp Ala Ile Thr Ala Val Val Leu Gly Gly Thr Ser Leu Phe Gly Gly 
                245                 250                 255     

Glu Gly Thr Leu Val Gly Thr Ile Ile Gly Ala Leu Ile Leu Gly Val 
            260                 265                 270         

Ile Asp Asn Gly Leu Asn Leu Leu Asn Val Ser Ser Phe Tyr Gln Asp 
        275                 280                 285             

Ala Val Lys Gly Leu Val Ile Leu Ile Ala Ile Met Leu Asp Arg Lys 
    290                 295                 300                 

Arg Ser Glu Gly Arg 
305                 

<210>   351
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   351
Met Thr Trp Phe Arg Arg Tyr Arg Leu Gly Pro Leu Leu Gly Leu Val 
                5                   10                  15      

Leu Leu Ile Leu Ile Leu Ala Val Ala Ser Arg Gln Phe Phe Thr Ala 
            20                  25                  30          

Ser Asn Leu Leu Asp Ile Ala Leu Gln Thr Ser Val Asn Ala Leu Leu 
        35                  40                  45              

Ala Ile Gly Met Thr Phe Val Ile Leu Thr Ala Gly Ile Asp Leu Ser 
    50                  55                  60                  

Val Gly Ser Thr Leu Ala Leu Thr Ser Ala Ile Ala Ala Gln Trp Met 
65                  70                  75                  80  

Val Gly Gly Thr Ser Pro Trp Leu Ala Gly Ile Ser Ala Leu Cys Ile 
                85                  90                  95      

Gly Ala Ile Ala Gly Ala Phe Asn Gly Val Leu Val Ala Tyr Ala Arg 
            100                 105                 110         

Leu Ala Pro Phe Ile Val Thr Leu Gly Thr Met Thr Leu Phe Arg Gly 
        115                 120                 125             

Leu Thr Glu Ile Tyr Thr Asn Gly Gln Pro Ile Phe Asn Leu Pro Tyr 
    130                 135                 140                 

Ser Phe Asn Gly Ile Gly Asn Gly Ala Val Leu Gly Val Pro Val Pro 
145                 150                 155                 160 

Val Trp Ile Thr Met Ile Val Phe Leu Ile Ala Trp Met Val Leu Ser 
                165                 170                 175     

Arg Thr Val Ala Gly Arg Arg Ile Tyr Ala Ile Gly Gly Asn Glu Lys 
            180                 185                 190         

Val Ala Tyr Leu Ala Gly Val Arg Ala Lys Arg Tyr Leu Val Ala Val 
        195                 200                 205             

Tyr Val Val Ser Gly Ile Leu Ala Ala Leu Ala Gly Leu Ile Leu Thr 
    210                 215                 220                 

Ser Arg Leu Ala Thr Ala Glu Pro Thr Ala Gly Gln Gly Tyr Glu Leu 
225                 230                 235                 240 

Asp Ala Ile Thr Ala Val Val Leu Gly Gly Thr Ser Leu Phe Gly Gly 
                245                 250                 255     

Glu Gly Thr Leu Val Gly Thr Ile Ile Gly Ala Leu Ile Leu Gly Val 
            260                 265                 270         

Ile Asp Asn Gly Leu Asn Leu Leu Asn Val Ser Ser Phe Tyr Gln Asp 
        275                 280                 285             

Ala Val Lys Gly Leu Val Ile Leu Ile Ala Ile Met Leu Asp Arg Lys 
    290                 295                 300                 

Arg Ser Glu Gly Arg 
305                 

<210>   352
<211>   309
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 341

<400>   352
Met Thr Trp Phe Arg Arg Tyr Arg Leu Gly Pro Leu Leu Gly Leu Val 
                5                   10                  15      

Leu Leu Ile Leu Ile Leu Ala Val Ala Ser Arg Gln Phe Phe Thr Ala 
            20                  25                  30          

Ser Asn Leu Leu Asp Ile Ala Leu Gln Thr Ser Val Asn Ala Leu Leu 
        35                  40                  45              

Ala Ile Gly Met Thr Phe Val Ile Leu Thr Ala Gly Ile Asp Leu Ser 
    50                  55                  60                  

Val Gly Ser Thr Leu Ala Leu Thr Ser Ala Ile Ala Ala Gln Trp Met 
65                  70                  75                  80  

Val Gly Gly Thr Ser Pro Trp Leu Ala Gly Ile Ser Ala Leu Cys Ile 
                85                  90                  95      

Gly Ala Ile Ala Gly Ala Phe Asn Gly Val Leu Val Ala Tyr Ala Arg 
            100                 105                 110         

Leu Ala Pro Phe Ile Val Thr Leu Gly Thr Met Thr Leu Phe Arg Gly 
        115                 120                 125             

Leu Thr Glu Ile Tyr Thr Asn Gly Gln Pro Ile Phe Asn Leu Pro Tyr 
    130                 135                 140                 

Ser Phe Asn Gly Leu Gly Asn Gly Ala Val Leu Gly Val Pro Val Pro 
145                 150                 155                 160 

Val Trp Ile Thr Met Ile Val Phe Leu Ile Ala Trp Met Val Leu Ser 
                165                 170                 175     

Arg Thr Val Ala Gly Arg Arg Ile Tyr Ala Ile Gly Gly Asn Glu Lys 
            180                 185                 190         

Val Ala Tyr Leu Ala Gly Val Arg Ala Lys Arg Tyr Leu Val Ala Val 
        195                 200                 205             

Tyr Val Val Ser Gly Ile Leu Ala Ala Leu Ala Gly Leu Ile Leu Thr 
    210                 215                 220                 

Ser Arg Leu Ala Thr Ala Asp Pro Thr Ala Gly Gln Gly Tyr Glu Leu 
225                 230                 235                 240 

Asp Ala Ile Thr Ala Val Val Leu Gly Gly Thr Ser Leu Phe Gly Gly 
                245                 250                 255     

Glu Gly Thr Leu Val Gly Thr Ile Ile Gly Ala Leu Ile Leu Gly Val 
            260                 265                 270         

Ile Asp Asn Gly Leu Asn Leu Leu Asn Val Ser Ser Phe Tyr Gln Asp 
        275                 280                 285             

Ala Val Lys Gly Leu Val Ile Leu Ile Ala Ile Met Leu Asp Arg Lys 
    290                 295                 300                 

Arg Ser Glu Gly Arg 
305                 

<210>   353
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   353
atgacttggt ttcgcaggta tcggttgggc cctattctcg ggttggtttt gctcattctc       60

atcctggctg tagcatctcg gcagttcttc actgcgagta acctgttgga cattgcgttg      120

caaacatccg tgaatgcgct cttggccatc gggatgacgt ttgtgatcct aacggccgga      180

attgacctgt cggtaggatc cacgctggca ctgacatcgg ccatcgcggc acagtggatg      240

gtgggcggta caagtccatg gctggcaggc atatctgcgt tatgcattgg agccatcgcc      300

ggagcgttca atggtgtcct cgtggcctat gcacgtcttg cgcccttcat cgtcacactt      360

ggaacgatga cgttgtttcg tggtttaacc gaaatttata cgaacggtca acccattttt      420

aacctgcctt attcctttaa cgggctcggg aacggggcgg ttctaggagt tcctgtcccc      480

gtctggatca cgatgatcgt gttccttatc gcatggatgg ttctctcgcg cactgtggca      540

ggcagaagga tttatgccat tggaggaaac gagaaagttg cgtacttggc gggggttcgc      600

gccaagcgat atctggtggc ggtctatgtg gtcagtggta ttttagcggc actggctggc      660

ctcattctca cttctcgtct tgcaactgcc gaaccgaccg cagggcaagg ttacgagctc      720

gatgcaatca cggccgtcgt actcggtgga actagtcttt tcggcggtga ggggacttta      780

gtcgggacca tcatcggcgc gctgattctc ggtgtcattg acaacggtct gaacttgtta      840

aatgtaagtt ccttctatca agatgctgtc aagggcctcg ttattctgat cgccatcatg      900

ttggaccgta agagatccga agggagataa                                       930


<210>   354
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   354
atgacttggt ttcgcaggta tcggattggc cctcttctcg ggttggtttt gctcattctc       60

atcctggctg tagcatctcg gcagttcttc actgcgagta acctgttgga cattgcgttg      120

caaacatccg tgaatgcgct cttggccatc gggatgacgt ttgtgatcct aacggccgga      180

attgacctgt cggtaggatc cacgctggca ctgacatcgg ccatcgcggc acagtggatg      240

gtgggcggta caagtccatg gctggcaggc atatctgcgt tatgcattgg agccatcgcc      300

ggagcgttca atggtgtcct cgtggcctat gcacgtcttg cgcccttcat cgtcacactt      360

ggaacgatga cgttgtttcg tggtttaacc gaaatttata cgaacggtca acccattttt      420

aacctgcctt attcctttaa cgggctcggg aacggggcgg ttctaggagt tcctgtcccc      480

gtctggatca cgatgatcgt gttccttatc gcatggatgg ttctctcgcg cactgtggca      540

ggcagaagga tttatgccat tggaggaaac gagaaagttg cgtacttggc gggggttcgc      600

gccaagcgat atctggtggc ggtctatgtg gtcagtggta ttttagcggc actggctggc      660

ctcattctca cttctcgtct tgcaactgcc gaaccgaccg cagggcaagg ttacgagctc      720

gatgcaatca cggccgtcgt actcggtgga actagtcttt tcggcggtga ggggacttta      780

gtcgggacca tcatcggcgc gctgattctc ggtgtcattg acaacggtct gaacttgtta      840

aatgtaagtt ccttctatca agatgctgtc aagggcctcg ttattctgat cgccatcatg      900

ttggaccgta agagatccga agggagataa                                       930


<210>   355
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   355
atgacttggt ttcgcaggta tcggttgggc cctcttctcg ggttggtttt gctcattctc       60

atcctggctg tagcatctcg gcagttcttc actgcgagta acctgttgga cattgcgatt      120

caaacatccg tgaatgcgct cttggccatc gggatgacgt ttgtgatcct aacggccgga      180

attgacctgt cggtaggatc cacgctggca ctgacatcgg ccatcgcggc acagtggatg      240

gtgggcggta caagtccatg gctggcaggc atatctgcgt tatgcattgg agccatcgcc      300

ggagcgttca atggtgtcct cgtggcctat gcacgtcttg cgcccttcat cgtcacactt      360

ggaacgatga cgttgtttcg tggtttaacc gaaatttata cgaacggtca acccattttt      420

aacctgcctt attcctttaa cgggctcggg aacggggcgg ttctaggagt tcctgtcccc      480

gtctggatca cgatgatcgt gttccttatc gcatggatgg ttctctcgcg cactgtggca      540

ggcagaagga tttatgccat tggaggaaac gagaaagttg cgtacttggc gggggttcgc      600

gccaagcgat atctggtggc ggtctatgtg gtcagtggta ttttagcggc actggctggc      660

ctcattctca cttctcgtct tgcaactgcc gaaccgaccg cagggcaagg ttacgagctc      720

gatgcaatca cggccgtcgt actcggtgga actagtcttt tcggcggtga ggggacttta      780

gtcgggacca tcatcggcgc gctgattctc ggtgtcattg acaacggtct gaacttgtta      840

aatgtaagtt ccttctatca agatgctgtc aagggcctcg ttattctgat cgccatcatg      900

ttggaccgta agagatccga agggagataa                                       930


<210>   356
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   356
atgacttggt ttcgcaggta tcggttgggc cctcttctcg ggttggtttt gctcattctc       60

atcctggctg tagcatctcg gcagttcttc actgcgagta acctgttgga cattgcgttg      120

caaacatccg tgaatgcgct cttggccatc gggatgacgt ttgtgatcct aacggccgga      180

attgacctgt cggtaggatc cacgctggca ctgacatcgg ccatcgcggc acagtggatg      240

gtgggcggta caagtccatg gctggcaggc atatctgcgt tatgcattgg agccatcgcc      300

ggagcgttca atggtgtcct cgtggcctat gcacgtcttg cgcccttcat cgtcacactt      360

ggaacgatga cgttgtttcg tggtttaacc gaaatttata cgaacggtca acccattttt      420

aacctgcctt attcctttaa cgggattggg aacggggcgg ttctaggagt tcctgtcccc      480

gtctggatca cgatgatcgt gttccttatc gcatggatgg ttctctcgcg cactgtggca      540

ggcagaagga tttatgccat tggaggaaac gagaaagttg cgtacttggc gggggttcgc      600

gccaagcgat atctggtggc ggtctatgtg gtcagtggta ttttagcggc actggctggc      660

ctcattctca cttctcgtct tgcaactgcc gaaccgaccg cagggcaagg ttacgagctc      720

gatgcaatca cggccgtcgt actcggtgga actagtcttt tcggcggtga ggggacttta      780

gtcgggacca tcatcggcgc gctgattctc ggtgtcattg acaacggtct gaacttgtta      840

aatgtaagtt ccttctatca agatgctgtc aagggcctcg ttattctgat cgccatcatg      900

ttggaccgta agagatccga agggagataa                                       930


<210>   357
<211>   930
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 342

<400>   357
atgacttggt ttcgcaggta tcggttgggc cctcttctcg ggttggtttt gctcattctc       60

atcctggctg tagcatctcg gcagttcttc actgcgagta acctgttgga cattgcgttg      120

caaacatccg tgaatgcgct cttggccatc gggatgacgt ttgtgatcct aacggccgga      180

attgacctgt cggtaggatc cacgctggca ctgacatcgg ccatcgcggc acagtggatg      240

gtgggcggta caagtccatg gctggcaggc atatctgcgt tatgcattgg agccatcgcc      300

ggagcgttca atggtgtcct cgtggcctat gcacgtcttg cgcccttcat cgtcacactt      360

ggaacgatga cgttgtttcg tggtttaacc gaaatttata cgaacggtca acccattttt      420

aacctgcctt attcctttaa cgggctcggg aacggggcgg ttctaggagt tcctgtcccc      480

gtctggatca cgatgatcgt gttccttatc gcatggatgg ttctctcgcg cactgtggca      540

ggcagaagga tttatgccat tggaggaaac gagaaagttg cgtacttggc gggggttcgc      600

gccaagcgat atctggtggc ggtctatgtg gtcagtggta ttttagcggc actggctggc      660

ctcattctca cttctcgtct tgcaactgcc gatccgaccg cagggcaagg ttacgagctc      720

gatgcaatca cggccgtcgt actcggtgga actagtcttt tcggcggtga ggggacttta      780

gtcgggacca tcatcggcgc gctgattctc ggtgtcattg acaacggtct gaacttgtta      840

aatgtaagtt ccttctatca agatgctgtc aagggcctcg ttattctgat cgccatcatg      900

ttggaccgta agagatccga agggagataa                                       930


<210>   358
<211>   315
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   358
Met Thr Met Ser Val Ile Asp Ala Phe Leu Arg Ser Thr Ala Gln Thr 
                5                   10                  15      

Ala Ala Glu Pro Ser Pro Gly Pro Ser Arg Leu Arg Glu Gly Ile Leu 
            20                  25                  30          

Ala Ala Cys Leu Leu Ala Pro Ala Leu Leu Phe Leu Val Ala Phe Val 
        35                  40                  45              

Tyr Ala Pro Ala Val Leu Ala Phe Ala Leu Ala Phe Phe Asn Phe His 
    50                  55                  60                  

Pro Gly Gly Thr Ala Thr Tyr Ala Gly Leu Ser Asn Phe His Ala Ala 
65                  70                  75                  80  

Leu Ser Asp Pro Leu Phe Trp Arg Ser Met Ala Asn Thr Gly Leu Tyr 
                85                  90                  95      

Ala Leu Met Met Val Pro Ser Thr Leu Val Leu Ser Val Ala Leu Ala 
            100                 105                 110         

Ala Leu Leu Gln Ser Asn Arg Arg Leu Phe Arg Phe Ala Gln Ser Leu 
        115                 120                 125             

Val Val Leu Pro Tyr Ile Thr Pro Ala Val Gly Thr Ala Ile Gly Trp 
    130                 135                 140                 

Leu Trp Met Tyr Asn Pro Asn Phe Gly Ile Leu Asn Ala Leu Leu Arg 
145                 150                 155                 160 

Gly Ile Gly Leu Lys Pro Ile Gly Trp Leu Asn Ser Pro His Trp Ala 
                165                 170                 175     

Met Pro Ala Val Val Leu Tyr Ser Leu Trp His Gly Ile Gly Phe Asp 
            180                 185                 190         

Val Leu Ile Leu Leu Ser Ala Met Ser Gln Val Pro Glu Gly Val Leu 
        195                 200                 205             

Glu Ser Ala Arg Val Asp Gly Ala Gly Pro Trp Thr Arg Leu Phe Arg 
    210                 215                 220                 

Ile Thr Leu Pro Leu Ile Ser Pro Thr Leu Phe Phe Ile Gly Val Ile 
225                 230                 235                 240 

Thr Thr Ile Gly Ser Leu Gln Ala Phe Ala Gln Val Tyr Ala Leu Ser 
                245                 250                 255     

Leu Ser Ser Gly Gly Pro Glu Asn Ala Thr Leu Thr Ala Leu Leu Tyr 
            260                 265                 270         

Ile Tyr Gln Gln Ala Phe Thr Asn Gly Gln Phe Ser Tyr Ala Ala Ala 
        275                 280                 285             

Met Ala Ala Met Leu Val Val Cys Ile Phe Ala Val Thr Ala Leu Thr 
    290                 295                 300                 

Arg Trp Ile Gly His Arg Leu Thr Phe Tyr Gln 
305                 310                 315 

<210>   359
<211>   948
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   359
atgaccatgt cggtaatcga cgcgttcctt cgctcgacag cgcagaccgc cgccgaacct       60

tccccaggcc catcccgcct gcgggaagga attttggcgg cgtgccttct cgcgcccgcc      120

cttctgtttc tcgtggcgtt tgtctatgcg ccggccgtgc tcgcctttgc gctcgcgttc      180

ttcaattttc accccggcgg cacggcgacc tacgccggtc tgagcaactt ccatgcggca      240

ttgtcggatc cgcttttctg gcgctccatg gcaaacacag ggttgtacgc cctcatgatg      300

gtgccttcca ccctggtgct gtccgtcgca ctcgcggcgc tgctccagtc gaaccggcgg      360

ctcttccgct tcgcgcagtc gttggtggtg ctcccgtaca tcacgccggc cgtcggcacc      420

gctatcggat ggctctggat gtacaacccc aacttcggca tcttgaacgc gcttttgcga      480

ggcatcggcc tgaagcccat cggatggttg aattcgcccc actgggcgat gcccgccgtg      540

gtcttatatt cgctttggca cggcatcggc tttgatgtgc tgatcctgct ctccgccatg      600

tctcaggtgc cagaaggcgt gttggagtcg gcgcgggtag acggcgcggg gccttggact      660

cggttgttcc gcatcacgct gcccctcatc tcgcccacgc tgtttttcat cggcgtgatc      720

accaccatcg gctctctgca ggcctttgcc caggtctacg cactgagtct ttcgagcggc      780

ggaccggaga acgccacgct gacggcgctt ttatacatct accaacaggc gttcacgaac      840

ggacagttct cttacgccgc cgccatggcc gcgatgctcg tggtctgcat ctttgcagtc      900

accgccctga cgcgctggat cggtcaccga ttgacgtttt accagtaa                   948


<210>   360
<211>   231
<212>   PRT
<213>   Methylococcus capsulatus str. Bath

<400>   360
Phe Val Gly Leu Asp Asn Tyr Arg Arg Leu Phe Gly Asp Pro Glu Phe 
                5                   10                  15      

Trp Gln Ala Leu Arg Asn Thr Leu Tyr Phe Val Ala Val Gly Gly Pro 
            20                  25                  30          

Leu Ser Val Leu Val Ser Leu Ala Ala Ala Leu Leu Val Asn His Arg 
        35                  40                  45              

Leu Ala Pro Phe Lys Gly Leu Phe Arg Ser Leu Leu Phe Leu Pro Val 
    50                  55                  60                  

Val Thr Thr Leu Val Ala Val Ala Val Val Trp Arg Tyr Met Tyr Gln 
65                  70                  75                  80  

Pro Arg Tyr Gly Ile Leu Asn His Leu Leu Gly Arg Phe Gly Leu Glu 
                85                  90                  95      

Pro Val Asp Trp Leu Gly Asp Pro Asp Trp Ala Met Pro Ala Ile Ile 
            100                 105                 110         

Val Met Ala Val Trp Lys Asn Phe Gly Phe Asn Met Ile Val Phe Val 
        115                 120                 125             

Ala Gly Leu Gln Ser Ile Pro Glu Ser Leu Tyr Glu Ala Ala Ser Ile 
    130                 135                 140                 

Asp Gly Ala Gly His Arg Arg Gln Phe Phe His Ile Thr Leu Pro Leu 
145                 150                 155                 160 

Leu Ala Pro Thr Phe Leu Phe Val Ala Val Ile Thr Val Ile Gly His 
                165                 170                 175     

Phe Gln Leu Phe Ala Glu Pro Tyr Val Met Thr Gln Gly Gly Pro Ala 
            180                 185                 190         

Gly Ser Thr Leu Ser Leu Ala Leu Leu Met Tyr Gln Gln Gly Phe Arg 
        195                 200                 205             

Trp Trp Asn Leu Gly Tyr Ala Ala Ala Ile Ala Phe Val Leu Phe Gly 
    210                 215                 220                 

Ile Val Gly Ser Phe Ala Val 
225                 230     

<210>   361
<211>   234
<212>   PRT
<213>   Petrotoga mobilis SJ95

<400>   361
Gly Asn Ala Ser Phe Ile Gly Phe Glu Asn Tyr Val Asn Leu Met His 
                5                   10                  15      

Asp Pro Leu Phe Trp Arg Ala Leu Leu Asn Thr Leu Tyr Ala Leu Val 
            20                  25                  30          

Val Ala Met Pro Ile Thr Ile Val Leu Ser Leu Ser Phe Ala Ala Leu 
        35                  40                  45              

Ile Asn Arg Glu Ala Thr Tyr Phe Lys Asn Phe Phe Lys Val Ser Phe 
    50                  55                  60                  

Tyr Leu Pro Ser Ile Thr Asn Thr Val Ala Ile Ala Ile Val Trp Ala 
65                  70                  75                  80  

Trp Met Leu Asn Pro Asp Tyr Gly Leu Leu Asn Trp Phe Leu Gly Leu 
                85                  90                  95      

Phe Gly Ile Gln Gly Pro Asn Trp Leu Gly Asp Pro Leu Trp Ala Met 
            100                 105                 110         

Pro Ser Val Ile Met Leu Val Val Trp Lys Ala Val Gly Tyr Asn Ile 
        115                 120                 125             

Ile Leu Phe Thr Ala Gly Leu Gln Asn Ile Pro Asp Tyr Leu Tyr Glu 
    130                 135                 140                 

Ala Ala Glu Leu Asp Gly Ala Ser Arg Phe Gln Gln Phe Leu His Val 
145                 150                 155                 160 

Thr Ile Pro Ser Leu Arg Pro Thr Ile Phe Phe Val Thr Val Met Thr 
                165                 170                 175     

Val Ile Gly Tyr Leu Gln Leu Phe Glu Glu Pro Tyr Met Leu Thr Ser 
            180                 185                 190         

Gly Gly Pro Leu Asn Ala Thr Leu Ser Ile Val Leu Tyr Leu Tyr Arg 
        195                 200                 205             

Gln Gly Phe Glu Phe Phe Lys Leu Gly Tyr Ser Ser Ser Ile Ala Phe 
    210                 215                 220                 

Val Leu Phe Leu Ile Ile Phe Ala Leu Thr 
225                 230                 

<210>   362
<211>   242
<212>   PRT
<213>   Clostridium botulinum A str. ATCC 3502

<400>   362
Gly Leu Asp Asn Phe Tyr Tyr Ile Phe Ser Asp Lys Glu Phe Leu Ile 
                5                   10                  15      

Ala Met Lys Asn Thr Phe Ile Tyr Val Leu Tyr Val Met Pro Ile Ser 
            20                  25                  30          

Ile Ile Leu Ser Leu Ile Ile Ala Ile Leu Leu Asn Ser Asn Ile Lys 
        35                  40                  45              

Phe Arg Gly Phe Phe Arg Thr Ile Tyr Phe Ile Pro Phe Ile Thr Ser 
    50                  55                  60                  

Thr Val Ala Ile Ser Met Val Trp Arg Trp Met Tyr His Ala Asp His 
65                  70                  75                  80  

Gly Ile Ile Asn Tyr Leu Leu Gln Val Ile Gly Leu Ser Pro Val Lys 
                85                  90                  95      

Trp Leu Ser Asp Pro Lys Trp Ala Met Pro Ser Leu Ile Ile Leu Ser 
            100                 105                 110         

Ile Trp Lys Ser Leu Gly Tyr Asn Ile Val Ile Phe Leu Ala Gly Leu 
        115                 120                 125             

Gln Asn Ile Asp Glu Gln Tyr Asn Leu Ala Ala Lys Leu Asp Gly Ala 
    130                 135                 140                 

Asn Lys Trp Glu Arg Ile Lys Asn Ile Thr Val Pro Leu Leu Ser Pro 
145                 150                 155                 160 

Thr Ile Phe Phe Val Cys Ile Met Thr Leu Ile Ser Ser Phe Lys Val 
                165                 170                 175     

Phe Gly Glu Ile Phe Ala Leu Phe Asp Lys Gln Pro Gly Pro Leu Asn 
            180                 185                 190         

Thr Cys Leu Thr Met Val Tyr Tyr Ile Tyr Asn Lys Phe Tyr Asn Gln 
        195                 200                 205             

Tyr Gln Tyr Gly Ile Ala Ser Ala Ala Val Phe Val Leu Phe Ile Ile 
    210                 215                 220                 

Ile Ser Leu Phe Asn Phe Ile Gln Phe Tyr Ile Gly Lys Lys Lys Val 
225                 230                 235                 240 

Glu Tyr 
        

<210>   363
<211>   242
<212>   PRT
<213>   Clostridium botulinum F str. Langeland

<400>   363
Gly Leu Asp Asn Phe Tyr Tyr Ile Phe Ser Asp Lys Glu Phe Leu Ile 
                5                   10                  15      

Ala Met Lys Asn Thr Phe Ile Tyr Val Leu Tyr Val Met Pro Ile Ser 
            20                  25                  30          

Ile Ile Leu Ser Leu Ile Ile Ala Ile Leu Leu Asn Ser Asn Ile Lys 
        35                  40                  45              

Phe Arg Gly Phe Phe Arg Thr Val Tyr Phe Ile Pro Phe Ile Thr Ser 
    50                  55                  60                  

Thr Val Ala Ile Ser Met Val Trp Arg Trp Met Tyr His Ala Asp His 
65                  70                  75                  80  

Gly Ile Ile Asn Tyr Leu Leu Gln Val Ile Gly Leu Ser Pro Val Lys 
                85                  90                  95      

Trp Leu Ser Asp Pro Lys Trp Ala Met Pro Ser Leu Ile Ile Leu Ser 
            100                 105                 110         

Ile Trp Lys Ser Leu Gly Tyr Asn Ile Val Ile Phe Leu Ala Gly Leu 
        115                 120                 125             

Gln Asn Ile Asp Glu Gln Tyr Asn Leu Ala Ala Lys Leu Asp Gly Ala 
    130                 135                 140                 

Asn Lys Trp Glu Arg Ile Lys Asn Ile Thr Val Pro Leu Leu Ser Pro 
145                 150                 155                 160 

Thr Ile Phe Phe Val Cys Ile Met Thr Leu Ile Ser Ser Phe Lys Val 
                165                 170                 175     

Phe Gly Glu Ile Phe Ala Leu Phe Asp Lys Gln Pro Gly Pro Leu Asn 
            180                 185                 190         

Thr Cys Leu Thr Met Val Tyr Tyr Ile Tyr Asn Lys Phe Tyr Asn Gln 
        195                 200                 205             

Tyr Gln Tyr Gly Ile Ala Ser Ala Ala Val Phe Val Leu Phe Ile Ile 
    210                 215                 220                 

Ile Ser Leu Phe Asn Phe Ile Gln Phe Tyr Ile Gly Lys Lys Lys Val 
225                 230                 235                 240 

Glu Tyr 
        

<210>   364
<211>   228
<212>   PRT
<213>   Roseiflexus sp. RS-1

<400>   364
Gly Leu Ala Asn Tyr Glu Lys Leu Phe Asn Asp Lys Leu Phe Trp Gln 
                5                   10                  15      

Ser Leu Arg Val Ser Ala Ile Tyr Ser Ile Val Ser Val Pro Leu Gly 
            20                  25                  30          

Leu Thr Ile Ala Leu Gly Leu Ala Leu Leu Leu Asn His Lys Met Arg 
        35                  40                  45              

Gly Ile Met Val Phe Arg Ser Val Tyr Tyr Leu Pro Thr Val Ile Ser 
    50                  55                  60                  

Gly Val Gly Val Ala Met Leu Trp Arg Trp Leu Phe Asn Gly Asp Phe 
65                  70                  75                  80  

Gly Ile Ile Asn Val Leu Leu Arg Gly Val Gly Ile Arg Gly Pro Asn 
                85                  90                  95      

Trp Leu Phe Asp Glu Thr Trp Ala Leu Val Ala Leu Ile Ile Ala Ser 
            100                 105                 110         

Leu Trp Gly Ile Gly Gly Thr Met Leu Ile Phe Leu Ala Gly Leu Gln 
        115                 120                 125             

Gly Ile Pro Gln Glu Leu Tyr Glu Ala Ala Glu Ile Asp Gly Ala Gly 
    130                 135                 140                 

Arg Trp Arg Gln Phe Ser Ser Ile Thr Leu Pro Met Ile Ser His Val 
145                 150                 155                 160 

Thr Phe Phe Asn Leu Val Leu Gly Val Ile Gly Ala Leu Gln Val Phe 
                165                 170                 175     

Thr Asp Ala Tyr Val Ile Thr Gly Gly Gly Pro Asn Asn Ala Thr Leu 
            180                 185                 190         

Phe Leu Ser Val Tyr Leu Tyr Arg His Ala Phe Gln Tyr Leu Asn Phe 
        195                 200                 205             

Gly Tyr Ala Ala Ala Val Ala Trp Val Leu Phe Leu Ile Val Leu Ala 
    210                 215                 220                 

Leu Thr Leu Leu 
225             

<210>   365
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   365
Met Thr Met Ser Val Ile Asp Ala Phe Leu Arg Ser Thr Ala Gln Thr 
                5                   10                  15      

Ala Ala Glu Pro Ser Pro Gly Pro Ser Arg Leu Arg Glu Gly Ile Leu 
            20                  25                  30          

Ala Ala Cys Leu Leu Ala Pro Ala Leu Leu Phe Leu Val Ala Phe Val 
        35                  40                  45              

Tyr Ala Pro Ala Val Leu Ala Phe Ala Leu Ala Phe Phe Asn Phe His 
    50                  55                  60                  

Pro Gly Gly Thr Ala Thr Tyr Ala Gly Leu Ser Asn Phe His Ala Ala 
65                  70                  75                  80  

Leu Ser Asp Pro Leu Phe Trp Arg Ser Met Ala Asn Thr Gly Leu Tyr 
                85                  90                  95      

Ala Leu Met Met Val Pro Ser Thr Leu Val Leu Ser Val Ala Leu Ala 
            100                 105                 110         

Ala Leu Leu Gln Ser Asn Arg Arg Leu Phe Arg Phe Ala Gln Ser Leu 
        115                 120                 125             

Val Val Leu Pro Tyr Ile Thr Pro Ala Val Gly Thr Ala Ile Gly Trp 
    130                 135                 140                 

Leu Trp Met Tyr Asn Pro Asn Phe Gly Ile Leu Asn Ala Leu Leu Arg 
145                 150                 155                 160 

Gly Ile Gly Leu Lys Pro Ile Gly Trp Leu Asn Ser Pro His Trp Ala 
                165                 170                 175     

Met Pro Ala Val Val Leu Tyr Ser Leu Trp His Gly Ile Gly Phe Asp 
            180                 185                 190         

Val Leu Ile Leu Leu Ser Ala Met Ser Gln Val Pro Glu Gly Val Leu 
        195                 200                 205             

Glu Ser Ala Arg Val Asp Gly Ala Gly Pro Trp Thr Arg Leu Phe Arg 
    210                 215                 220                 

Ile Thr Leu Pro Leu Ile Ser Pro Thr Leu Phe Phe Ile Gly Val Ile 
225                 230                 235                 240 

Thr Thr Ile Gly Ser Leu Gln Ala Phe Ala Gln Val Tyr Ala Leu Ser 
                245                 250                 255     

Leu Ser Ser Gly Gly Pro Asp Asn Ala Thr Leu Thr Ala Leu Leu Tyr 
            260                 265                 270         

Ile Tyr Gln Gln Ala Phe Thr Asn Gly Gln Phe Ser Tyr Ala Ala Ala 
        275                 280                 285             

Met Ala Ala Met Leu Val Val Cys Ile Phe Ala Val Thr Ala Leu Thr 
    290                 295                 300                 

Arg Trp Ile Gly His Arg Leu Thr Phe Tyr Gln 
305                 310                 315 

<210>   366
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   366
Met Thr Met Ser Val Ile Asp Ala Phe Leu Arg Ser Thr Ala Gln Thr 
                5                   10                  15      

Ala Ala Glu Pro Ser Pro Gly Pro Ser Arg Leu Arg Glu Gly Ile Leu 
            20                  25                  30          

Ala Ala Cys Leu Leu Ala Pro Ala Leu Leu Phe Leu Val Ala Phe Val 
        35                  40                  45              

Tyr Ala Pro Ala Val Leu Ala Phe Ala Leu Ala Phe Phe Asn Phe His 
    50                  55                  60                  

Pro Gly Gly Thr Ala Thr Tyr Ala Gly Leu Ser Asn Phe His Ala Ala 
65                  70                  75                  80  

Leu Ser Asp Pro Leu Phe Trp Arg Ser Met Ala Asn Thr Gly Leu Tyr 
                85                  90                  95      

Ala Leu Met Met Val Pro Ser Thr Leu Val Leu Ser Val Ala Leu Ala 
            100                 105                 110         

Ala Leu Leu Gln Ser Asn Arg Arg Leu Phe Arg Phe Ala Gln Ser Leu 
        115                 120                 125             

Val Val Leu Pro Tyr Ile Thr Pro Ala Val Gly Thr Ala Ile Gly Trp 
    130                 135                 140                 

Leu Trp Met Tyr Asn Pro Asn Phe Gly Ile Leu Asn Ala Leu Leu Arg 
145                 150                 155                 160 

Gly Ile Gly Leu Lys Pro Ile Gly Trp Leu Asn Ser Pro His Trp Ala 
                165                 170                 175     

Met Pro Ala Val Val Leu Tyr Ser Leu Trp His Gly Ile Gly Phe Glu 
            180                 185                 190         

Val Leu Ile Leu Leu Ser Ala Met Ser Gln Val Pro Glu Gly Val Leu 
        195                 200                 205             

Glu Ser Ala Arg Val Asp Gly Ala Gly Pro Trp Thr Arg Leu Phe Arg 
    210                 215                 220                 

Ile Thr Leu Pro Leu Ile Ser Pro Thr Leu Phe Phe Ile Gly Val Ile 
225                 230                 235                 240 

Thr Thr Ile Gly Ser Leu Gln Ala Phe Ala Gln Val Tyr Ala Leu Ser 
                245                 250                 255     

Leu Ser Ser Gly Gly Pro Glu Asn Ala Thr Leu Thr Ala Leu Leu Tyr 
            260                 265                 270         

Ile Tyr Gln Gln Ala Phe Thr Asn Gly Gln Phe Ser Tyr Ala Ala Ala 
        275                 280                 285             

Met Ala Ala Met Leu Val Val Cys Ile Phe Ala Val Thr Ala Leu Thr 
    290                 295                 300                 

Arg Trp Ile Gly His Arg Leu Thr Phe Tyr Gln 
305                 310                 315 

<210>   367
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   367
Met Thr Met Ser Val Ile Asp Ala Phe Leu Arg Ser Thr Ala Gln Thr 
                5                   10                  15      

Ala Ala Glu Pro Ser Pro Gly Pro Ser Arg Leu Arg Glu Gly Ile Leu 
            20                  25                  30          

Ala Ala Cys Leu Leu Ala Pro Ala Leu Leu Phe Leu Val Ala Phe Val 
        35                  40                  45              

Tyr Ala Pro Ala Val Leu Ala Phe Ala Leu Ala Phe Phe Asn Phe His 
    50                  55                  60                  

Pro Gly Gly Thr Ala Thr Tyr Ala Gly Leu Ser Asn Phe His Ala Ala 
65                  70                  75                  80  

Leu Ser Asp Pro Leu Phe Trp Arg Ser Met Ala Asn Thr Gly Leu Tyr 
                85                  90                  95      

Ala Leu Met Met Val Pro Ser Thr Leu Val Leu Ser Val Ala Leu Ala 
            100                 105                 110         

Ala Leu Leu Gln Ser Asn Arg Arg Leu Phe Arg Phe Ala Gln Ser Leu 
        115                 120                 125             

Val Val Leu Pro Tyr Ile Thr Pro Ala Val Gly Thr Ala Ile Gly Trp 
    130                 135                 140                 

Leu Trp Met Tyr Asn Pro Asn Phe Gly Ile Leu Asn Ala Leu Leu Arg 
145                 150                 155                 160 

Gly Ile Gly Leu Lys Pro Ile Gly Trp Leu Asn Ser Pro His Trp Ala 
                165                 170                 175     

Met Pro Ala Val Val Leu Tyr Ser Leu Trp His Gly Ile Gly Phe Asp 
            180                 185                 190         

Val Leu Ile Leu Leu Ser Ala Met Ser Gln Val Pro Glu Gly Val Leu 
        195                 200                 205             

Glu Ser Ala Arg Val Asp Gly Ala Gly Pro Trp Thr Arg Leu Phe Arg 
    210                 215                 220                 

Ile Thr Leu Pro Leu Ile Ser Pro Thr Leu Phe Phe Ile Gly Val Ile 
225                 230                 235                 240 

Thr Thr Ile Gly Ser Leu Gln Ala Phe Ala Gln Val Tyr Ala Leu Ser 
                245                 250                 255     

Leu Ser Ser Gly Gly Pro Glu Asn Ala Thr Leu Thr Ala Leu Leu Tyr 
            260                 265                 270         

Ile Tyr Gln Gln Ala Phe Thr Gln Gly Gln Phe Ser Tyr Ala Ala Ala 
        275                 280                 285             

Met Ala Ala Met Leu Val Val Cys Ile Phe Ala Val Thr Ala Leu Thr 
    290                 295                 300                 

Arg Trp Ile Gly His Arg Leu Thr Phe Tyr Gln 
305                 310                 315 

<210>   368
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   368
Met Thr Met Ser Val Ile Asp Ala Phe Leu Arg Ser Thr Ala Gln Thr 
                5                   10                  15      

Ala Ala Glu Pro Ser Pro Gly Pro Ser Arg Leu Arg Glu Gly Ile Leu 
            20                  25                  30          

Ala Ala Cys Leu Leu Ala Pro Ala Leu Leu Phe Leu Val Ala Phe Val 
        35                  40                  45              

Tyr Ala Pro Ala Val Leu Ala Phe Ala Leu Ala Phe Phe Asn Phe His 
    50                  55                  60                  

Pro Gly Gly Thr Ala Thr Tyr Ala Gly Leu Ser Asn Phe His Ala Ala 
65                  70                  75                  80  

Leu Ser Asp Pro Leu Phe Trp Arg Ser Met Ala Asn Thr Gly Leu Tyr 
                85                  90                  95      

Ala Leu Met Met Val Pro Ser Thr Leu Val Leu Ser Val Ala Leu Ala 
            100                 105                 110         

Ala Leu Leu Gln Ser Asn Arg Arg Leu Phe Arg Phe Ala Gln Ser Leu 
        115                 120                 125             

Val Val Leu Pro Tyr Ile Thr Pro Ala Val Gly Thr Ala Ile Gly Trp 
    130                 135                 140                 

Leu Trp Met Tyr Asn Pro Asn Phe Gly Ile Leu Asn Ala Leu Leu Arg 
145                 150                 155                 160 

Gly Ile Gly Leu Lys Pro Ile Gly Trp Leu Asn Ser Pro His Trp Ala 
                165                 170                 175     

Met Pro Ala Val Val Leu Tyr Ser Leu Trp His Gly Ile Gly Phe Asp 
            180                 185                 190         

Val Leu Ile Leu Leu Ser Ala Met Ser Gln Val Pro Glu Gly Val Leu 
        195                 200                 205             

Asp Ser Ala Arg Val Asp Gly Ala Gly Pro Trp Thr Arg Leu Phe Arg 
    210                 215                 220                 

Ile Thr Leu Pro Leu Ile Ser Pro Thr Leu Phe Phe Ile Gly Val Ile 
225                 230                 235                 240 

Thr Thr Ile Gly Ser Leu Gln Ala Phe Ala Gln Val Tyr Ala Leu Ser 
                245                 250                 255     

Leu Ser Ser Gly Gly Pro Glu Asn Ala Thr Leu Thr Ala Leu Leu Tyr 
            260                 265                 270         

Ile Tyr Gln Gln Ala Phe Thr Asn Gly Gln Phe Ser Tyr Ala Ala Ala 
        275                 280                 285             

Met Ala Ala Met Leu Val Val Cys Ile Phe Ala Val Thr Ala Leu Thr 
    290                 295                 300                 

Arg Trp Ile Gly His Arg Leu Thr Phe Tyr Gln 
305                 310                 315 

<210>   369
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 358

<400>   369
Met Thr Met Ser Val Ile Asp Ala Phe Leu Arg Ser Thr Ala Gln Thr 
                5                   10                  15      

Ala Ala Glu Pro Ser Pro Gly Pro Ser Arg Leu Arg Glu Gly Ile Leu 
            20                  25                  30          

Ala Ala Cys Leu Leu Ala Pro Ala Leu Leu Phe Leu Val Ala Phe Val 
        35                  40                  45              

Tyr Ala Pro Ala Val Leu Ala Phe Ala Leu Ala Phe Phe Asn Phe His 
    50                  55                  60                  

Pro Gly Gly Thr Ala Thr Tyr Ala Gly Leu Ser Asn Phe His Ala Ala 
65                  70                  75                  80  

Leu Ser Asp Pro Leu Phe Trp Arg Ser Met Ala Asn Thr Gly Leu Tyr 
                85                  90                  95      

Ala Leu Met Met Val Pro Ser Thr Leu Val Leu Ser Val Ala Leu Ala 
            100                 105                 110         

Ala Leu Ile Gln Ser Asn Arg Arg Leu Phe Arg Phe Ala Gln Ser Leu 
        115                 120                 125             

Val Val Leu Pro Tyr Ile Thr Pro Ala Val Gly Thr Ala Ile Gly Trp 
    130                 135                 140                 

Leu Trp Met Tyr Asn Pro Asn Phe Gly Ile Leu Asn Ala Leu Leu Arg 
145                 150                 155                 160 

Gly Ile Gly Leu Lys Pro Ile Gly Trp Leu Asn Ser Pro His Trp Ala 
                165                 170                 175     

Met Pro Ala Val Val Leu Tyr Ser Leu Trp His Gly Ile Gly Phe Asp 
            180                 185                 190         

Val Leu Ile Leu Leu Ser Ala Met Ser Gln Val Pro Glu Gly Val Leu 
        195                 200                 205             

Glu Ser Ala Arg Val Asp Gly Ala Gly Pro Trp Thr Arg Leu Phe Arg 
    210                 215                 220                 

Ile Thr Leu Pro Leu Ile Ser Pro Thr Leu Phe Phe Ile Gly Val Ile 
225                 230                 235                 240 

Thr Thr Ile Gly Ser Leu Gln Ala Phe Ala Gln Val Tyr Ala Leu Ser 
                245                 250                 255     

Leu Ser Ser Gly Gly Pro Glu Asn Ala Thr Leu Thr Ala Leu Leu Tyr 
            260                 265                 270         

Ile Tyr Gln Gln Ala Phe Thr Asn Gly Gln Phe Ser Tyr Ala Ala Ala 
        275                 280                 285             

Met Ala Ala Met Leu Val Val Cys Ile Phe Ala Val Thr Ala Leu Thr 
    290                 295                 300                 

Arg Trp Ile Gly His Arg Leu Thr Phe Tyr Gln 
305                 310                 315 

<210>   370
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   370
atgaccatgt cggtaatcga cgcgttcctt cgctcgacag cgcagaccgc cgccgaacct       60

tccccaggcc catcccgcct gcgggaagga attttggcgg cgtgccttct cgcgcccgcc      120

cttctgtttc tcgtggcgtt tgtctatgcg ccggccgtgc tcgcctttgc gctcgcgttc      180

ttcaattttc accccggcgg cacggcgacc tacgccggtc tgagcaactt ccatgcggca      240

ttgtcggatc cgcttttctg gcgctccatg gcaaacacag ggttgtacgc cctcatgatg      300

gtgccttcca ccctggtgct gtccgtcgca ctcgcggcgc tgctccagtc gaaccggcgg      360

ctcttccgct tcgcgcagtc gttggtggtg ctcccgtaca tcacgccggc cgtcggcacc      420

gctatcggat ggctctggat gtacaacccc aacttcggca tcttgaacgc gcttttgcga      480

ggcatcggcc tgaagcccat cggatggttg aattcgcccc actgggcgat gcccgccgtg      540

gtcttatatt cgctttggca cggcatcggc tttgatgtgc tgatcctgct ctccgccatg      600

tctcaggtgc cagaaggcgt gttggagtcg gcgcgggtag acggcgcggg gccttggact      660

cggttgttcc gcatcacgct gcccctcatc tcgcccacgc tgtttttcat cggcgtgatc      720

accaccatcg gctctctgca ggcctttgcc caggtctacg cactgagtct ttcgagcggc      780

ggaccggata acgccacgct gacggcgctt ttatacatct accaacaggc gttcacgaac      840

ggacagttct cttacgccgc cgccatggcc gcgatgctcg tggtctgcat ctttgcagtc      900

accgccctga cgcgctggat cggtcaccga ttgacgtttt accagtaa                   948


<210>   371
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   371
atgaccatgt cggtaatcga cgcgttcctt cgctcgacag cgcagaccgc cgccgaacct       60

tccccaggcc catcccgcct gcgggaagga attttggcgg cgtgccttct cgcgcccgcc      120

cttctgtttc tcgtggcgtt tgtctatgcg ccggccgtgc tcgcctttgc gctcgcgttc      180

ttcaattttc accccggcgg cacggcgacc tacgccggtc tgagcaactt ccatgcggca      240

ttgtcggatc cgcttttctg gcgctccatg gcaaacacag ggttgtacgc cctcatgatg      300

gtgccttcca ccctggtgct gtccgtcgca ctcgcggcgc tgctccagtc gaaccggcgg      360

ctcttccgct tcgcgcagtc gttggtggtg ctcccgtaca tcacgccggc cgtcggcacc      420

gctatcggat ggctctggat gtacaacccc aacttcggca tcttgaacgc gcttttgcga      480

ggcatcggcc tgaagcccat cggatggttg aattcgcccc actgggcgat gcccgccgtg      540

gtcttatatt cgctttggca cggcatcggc tttgaagtgc tgatcctgct ctccgccatg      600

tctcaggtgc cagaaggcgt gttggagtcg gcgcgggtag acggcgcggg gccttggact      660

cggttgttcc gcatcacgct gcccctcatc tcgcccacgc tgtttttcat cggcgtgatc      720

accaccatcg gctctctgca ggcctttgcc caggtctacg cactgagtct ttcgagcggc      780

ggaccggaga acgccacgct gacggcgctt ttatacatct accaacaggc gttcacgaac      840

ggacagttct cttacgccgc cgccatggcc gcgatgctcg tggtctgcat ctttgcagtc      900

accgccctga cgcgctggat cggtcaccga ttgacgtttt accagtaa                   948


<210>   372
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   372
atgaccatgt cggtaatcga cgcgttcctt cgctcgacag cgcagaccgc cgccgaacct       60

tccccaggcc catcccgcct gcgggaagga attttggcgg cgtgccttct cgcgcccgcc      120

cttctgtttc tcgtggcgtt tgtctatgcg ccggccgtgc tcgcctttgc gctcgcgttc      180

ttcaattttc accccggcgg cacggcgacc tacgccggtc tgagcaactt ccatgcggca      240

ttgtcggatc cgcttttctg gcgctccatg gcaaacacag ggttgtacgc cctcatgatg      300

gtgccttcca ccctggtgct gtccgtcgca ctcgcggcgc tgctccagtc gaaccggcgg      360

ctcttccgct tcgcgcagtc gttggtggtg ctcccgtaca tcacgccggc cgtcggcacc      420

gctatcggat ggctctggat gtacaacccc aacttcggca tcttgaacgc gcttttgcga      480

ggcatcggcc tgaagcccat cggatggttg aattcgcccc actgggcgat gcccgccgtg      540

gtcttatatt cgctttggca cggcatcggc tttgatgtgc tgatcctgct ctccgccatg      600

tctcaggtgc cagaaggcgt gttggagtcg gcgcgggtag acggcgcggg gccttggact      660

cggttgttcc gcatcacgct gcccctcatc tcgcccacgc tgtttttcat cggcgtgatc      720

accaccatcg gctctctgca ggcctttgcc caggtctacg cactgagtct ttcgagcggc      780

ggaccggaga acgccacgct gacggcgctt ttatacatct accaacaggc gttcacgcaa      840

ggacagttct cttacgccgc cgccatggcc gcgatgctcg tggtctgcat ctttgcagtc      900

accgccctga cgcgctggat cggtcaccga ttgacgtttt accagtaa                   948


<210>   373
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   373
atgaccatgt cggtaatcga cgcgttcctt cgctcgacag cgcagaccgc cgccgaacct       60

tccccaggcc catcccgcct gcgggaagga attttggcgg cgtgccttct cgcgcccgcc      120

cttctgtttc tcgtggcgtt tgtctatgcg ccggccgtgc tcgcctttgc gctcgcgttc      180

ttcaattttc accccggcgg cacggcgacc tacgccggtc tgagcaactt ccatgcggca      240

ttgtcggatc cgcttttctg gcgctccatg gcaaacacag ggttgtacgc cctcatgatg      300

gtgccttcca ccctggtgct gtccgtcgca ctcgcggcgc tgctccagtc gaaccggcgg      360

ctcttccgct tcgcgcagtc gttggtggtg ctcccgtaca tcacgccggc cgtcggcacc      420

gctatcggat ggctctggat gtacaacccc aacttcggca tcttgaacgc gcttttgcga      480

ggcatcggcc tgaagcccat cggatggttg aattcgcccc actgggcgat gcccgccgtg      540

gtcttatatt cgctttggca cggcatcggc tttgatgtgc tgatcctgct ctccgccatg      600

tctcaggtgc cagaaggcgt gttggattcg gcgcgggtag acggcgcggg gccttggact      660

cggttgttcc gcatcacgct gcccctcatc tcgcccacgc tgtttttcat cggcgtgatc      720

accaccatcg gctctctgca ggcctttgcc caggtctacg cactgagtct ttcgagcggc      780

ggaccggaga acgccacgct gacggcgctt ttatacatct accaacaggc gttcacgaac      840

ggacagttct cttacgccgc cgccatggcc gcgatgctcg tggtctgcat ctttgcagtc      900

accgccctga cgcgctggat cggtcaccga ttgacgtttt accagtaa                   948


<210>   374
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 359

<400>   374
atgaccatgt cggtaatcga cgcgttcctt cgctcgacag cgcagaccgc cgccgaacct       60

tccccaggcc catcccgcct gcgggaagga attttggcgg cgtgccttct cgcgcccgcc      120

cttctgtttc tcgtggcgtt tgtctatgcg ccggccgtgc tcgcctttgc gctcgcgttc      180

ttcaattttc accccggcgg cacggcgacc tacgccggtc tgagcaactt ccatgcggca      240

ttgtcggatc cgcttttctg gcgctccatg gcaaacacag ggttgtacgc cctcatgatg      300

gtgccttcca ccctggtgct gtccgtcgca ctcgcggcgc tgattcagtc gaaccggcgg      360

ctcttccgct tcgcgcagtc gttggtggtg ctcccgtaca tcacgccggc cgtcggcacc      420

gctatcggat ggctctggat gtacaacccc aacttcggca tcttgaacgc gcttttgcga      480

ggcatcggcc tgaagcccat cggatggttg aattcgcccc actgggcgat gcccgccgtg      540

gtcttatatt cgctttggca cggcatcggc tttgatgtgc tgatcctgct ctccgccatg      600

tctcaggtgc cagaaggcgt gttggagtcg gcgcgggtag acggcgcggg gccttggact      660

cggttgttcc gcatcacgct gcccctcatc tcgcccacgc tgtttttcat cggcgtgatc      720

accaccatcg gctctctgca ggcctttgcc caggtctacg cactgagtct ttcgagcggc      780

ggaccggaga acgccacgct gacggcgctt ttatacatct accaacaggc gttcacgaac      840

ggacagttct cttacgccgc cgccatggcc gcgatgctcg tggtctgcat ctttgcagtc      900

accgccctga cgcgctggat cggtcaccga ttgacgtttt accagtaa                   948


<210>   375
<211>   459
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   375
Met Val Leu Thr Gln Tyr Ser Ala Ile Gln Arg Gly Arg Ile His Val 
                5                   10                  15      

Arg Arg Ser Trp Val Leu Gly Thr Ala Ser Ala Val Ile Leu Ala Gly 
            20                  25                  30          

Ala Gly Thr Gly Val Ala Leu Asp Arg Gly His Ala His Asp Ala Val 
        35                  40                  45              

Arg Val Ala Pro Ala Glu Ala Ala Ser Ala Asn Gly Val Val Gln Ile 
    50                  55                  60                  

Thr Phe Trp Asn Gly His Pro Ser Gly Ala Leu Lys Lys Glu Met His 
65                  70                  75                  80  

Thr Leu Val Asp Glu Phe Asn Ala Thr His Pro His Ile His Val Thr 
                85                  90                  95      

Val Ile Asp Lys Tyr Ala Gln Ile Gln Pro Val Thr Ala Ala Met Thr 
            100                 105                 110         

Ala Gly Asp Ala Pro Asn Val Ile Met Pro His Leu Asp Ala Ala Gln 
        115                 120                 125             

Gln Phe Ala Ala Asp Gly Tyr Leu Val Asn Leu Thr Pro Tyr Ile Asp 
    130                 135                 140                 

Gly Pro Ser Gly Phe Thr Lys Ala Gln Leu Ser Ser Phe Phe Tyr Pro 
145                 150                 155                 160 

Ser Val Trp Asn Gly Arg Ala Ile Glu Pro Gly Lys Gln Tyr Ile Leu 
                165                 170                 175     

Pro Phe Glu Glu Asn Gly His Met Val Ile Phe Tyr Asn Ala Asp Leu 
            180                 185                 190         

Phe Lys Lys Ala Gly Ile Ser Ser Pro Pro Lys Thr Trp Gln Gln Leu 
        195                 200                 205             

Arg Ala Asp Ala Arg Lys Ile Thr Ala Leu Gly Gly Ser Ile His Gly 
    210                 215                 220                 

Ile Ala Trp Thr Pro Ser Met Glu Gln Phe Leu Thr Met Val Ala Asp 
225                 230                 235                 240 

Asn Ser Gly Lys Ile Trp Ala Ser Ser Ser Glu Thr Arg Phe Ala Leu 
                245                 250                 255     

Asn Asn Pro Gln Ala Val Ala Thr Leu Ser Phe Leu Arg Asp Leu Val 
            260                 265                 270         

Ala Gln Gly Asp Met Ile Leu Thr Gln Asn Tyr Asp Tyr Gln Leu Asp 
        275                 280                 285             

Phe Gly Thr Gly Asn Ile Gly Leu Leu Ile Glu Ser Ser Ala Gly Trp 
    290                 295                 300                 

Thr Tyr Asp Val Gln Ser Val Gly Gly Lys Phe Pro Val Lys Ala Ser 
305                 310                 315                 320 

Pro Ala Pro Ala Gly Thr Ser Gly Arg Ala Tyr Asn Tyr Val Asp Gly 
                325                 330                 335     

Asp Ser Leu Ala Ile Leu Asn Thr Gly Thr Lys Ala Gln Gln Asp Ala 
            340                 345                 350         

Ala Trp Thr Phe Ile Arg Trp Leu Ala Ser Pro Ala Glu Asn Ala Gln 
        355                 360                 365             

Trp Asp Gln Ala Ala Asn Tyr Leu Pro Ile Gly Pro Ala Ala Ala Ala 
    370                 375                 380                 

Gln Leu Lys Pro Tyr Tyr Ala Ser His Pro Asp Gln Ala Ala Ala Phe 
385                 390                 395                 400 

Thr Asn Pro Ser Thr Trp Leu Thr Asp Pro Ala Ala Asn Ala Thr Gln 
                405                 410                 415     

Tyr Tyr Ala Ala Leu Thr Ala Met Gln Thr Glu Leu Leu Lys Ala Leu 
            420                 425                 430         

Asn Gly Gln Glu Ser Pro Gln Gln Ala Ile Ala Asn Met Asn Thr Val 
        435                 440                 445             

Gly Asn Gln Tyr Leu Ser Gly Glu Arg Arg Ser 
    450                 455                 

<210>   376
<211>   1380
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   376
atggtcttga cccaatattc ggccattcaa agggggagaa ttcacgtgag acgaagctgg       60

gttctcggca ccgcatccgc cgtgatcttg gcgggcgcgg gaaccggtgt ggcactcgat      120

cgcgggcacg cgcacgacgc ggttcgcgtg gcgcctgcgg aagcggcgag cgcaaacgga      180

gtcgttcaga tcacattttg gaacgggcat ccttctggcg cgctgaagaa ggagatgcac      240

acccttgtcg acgagttcaa cgccacccat cctcacatcc atgtcacggt tatcgacaag      300

tacgcgcaga ttcagcccgt caccgccgca atgaccgctg gcgatgcgcc gaacgtgatc      360

atgcctcacc tcgatgccgc tcagcagttc gcggcagacg gctacctcgt gaacctgacg      420

ccgtacatcg acggaccgag cggtttcacg aaggctcaac tctcctcgtt cttctatccc      480

tctgtctgga acggccgcgc catcgagccg ggcaaacaat acatcctccc gttcgaagaa      540

aacgggcata tggtaatctt ctacaacgcg gatctgttca agaaggcggg catctcgtcg      600

ccgcccaaga cgtggcagca gctcagggcg gatgcgcgga agatcacggc gctcggcgga      660

agcatccacg gcattgcatg gaccccctcc atggagcaat tcctgacgat ggtcgcagac      720

aacagcggaa agatttgggc atccagcagc gagacgcggt tcgccctgaa caacccgcag      780

gccgtcgcca ccctctcctt tttgcgcgat ctcgtcgcgc agggcgacat gatcctcacc      840

caaaactacg actatcaatt ggattttggc acgggcaaca tcggtttgct catcgaatcg      900

tccgcagggt ggacctatga cgtgcagtcg gtcggcggca agttcccggt caaagcgtcc      960

ccggcgcccg ctggcacgtc cggccgcgcg tacaactacg tcgacggcga cagcctcgcc     1020

attttgaaca cgggaaccaa ggcgcagcag gatgcggcgt ggacgttcat tcgctggctc     1080

gcgagccccg cggaaaacgc gcagtgggat caggcggcga attaccttcc catcggaccc     1140

gctgcagcag cccagctgaa accgtactat gcttcccatc ccgaccaggc ggccgccttc     1200

acgaatccat ccacatggct gacggatccg gccgcgaacg cgacgcaata ctacgccgcg     1260

ctgaccgcca tgcagactga actgctgaag gcgctcaacg ggcaggaatc gccgcaacag     1320

gccatcgcga acatgaatac cgtcggcaat caatacctga gcggcgagcg caggagctga     1380

                                                                      1380


<210>   377
<211>   391
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   377
Val Lys Val Thr Phe Trp His Ala Met Gly Gly Val Ala Gly Glu Ala 
                5                   10                  15      

Val Gln Arg Leu Val Asp Gln Phe Asn Ser Ser Gln Asp Lys Val Glu 
            20                  25                  30          

Val Glu Ala Val Tyr Gln Gly Thr Tyr Asp Asp Ala Leu Gln Lys Leu 
        35                  40                  45              

Arg Ala Ala Gly Ser Asp Gly Pro Thr Ile Met Gln Val Tyr Glu Ile 
    50                  55                  60                  

Gly Ser Arg Phe Met Ile Asp Ser Gly Met Ile Thr Pro Met Gln Asn 
65                  70                  75                  80  

Phe Val Asp Ala Asp Gly Phe Ser Ile Asp Asp Phe Glu Pro Asn Ile 
                85                  90                  95      

Leu Gly Tyr Tyr Thr Phe Asp Gly Arg Leu Tyr Ser Met Pro Phe Asn 
            100                 105                 110         

Thr Ser Thr Pro Ile Val Tyr Tyr Asn Lys Asp Ala Phe Arg Glu Ala 
        115                 120                 125             

Gly Leu Asp Pro Glu Arg Pro Pro Arg Thr Phe Glu Glu Phe Lys Glu 
    130                 135                 140                 

Tyr Ala Arg Lys Leu Thr Val Thr Gln Gly Gly Glu Thr Arg Tyr Gly 
145                 150                 155                 160 

Ala Ser Ile Ala Leu Tyr Gly Trp Phe Phe Glu Gln Phe Leu Ala Val 
                165                 170                 175     

Gln Gly Ala His Tyr Val Asp Asn Asp Asn Gly Arg Ser Ala Arg Ala 
            180                 185                 190         

Thr Lys Ala Ile Ile Asn Ser Pro Glu Gly Glu Arg Phe Val Thr Trp 
        195                 200                 205             

Leu Lys Glu Met Val Asp Glu Gly Val Ala Ile Asn Leu Gly Arg Arg 
    210                 215                 220                 

Thr Ala Asp Thr Gln Ala Ala Phe Ser Ser Gly Gln Val Ala Met Thr 
225                 230                 235                 240 

Leu Asp Ser Thr Ala Ala Leu Gly Asn Ile Leu Asn Gly Val Gly Asp 
                245                 250                 255     

Lys Phe Glu Ile Gly Thr Ala Phe Leu Pro Arg Pro Glu Gly Ala Ala 
            260                 265                 270         

Glu Gly Gly Val Ile Ile Gly Gly Ala Ser Leu Trp Ile Thr Asn Thr 
        275                 280                 285             

Lys Pro Leu Lys Glu Gln Trp Ala Ala Trp Glu Phe Val Lys Trp Leu 
    290                 295                 300                 

Thr Thr Pro Glu Val Gln Ala Glu Trp Ser Ile Ala Thr Gly Tyr Phe 
305                 310                 315                 320 

Pro Val Arg Lys Ala Ala Tyr Asp Gln Gln Ile Leu Lys Asp Trp His 
                325                 330                 335     

Ala Gln Arg Pro Gln Phe Thr Thr Ala Ile Glu Gln Leu Arg Ala Ser 
            340                 345                 350         

Pro Leu Ser Thr Val Thr Gln Gly Ala Val Ile Gly Thr Phe Pro Gln 
        355                 360                 365             

Ala Arg Gln Ile Val Glu Ala Ala Met Glu Ser Val Val Leu Gly Gln 
    370                 375                 380                 

Ala Thr Ala Ala Glu Ala Leu 
385                 390     

<210>   378
<211>   328
<212>   PRT
<213>   Renibacterium salmoninarum ATCC 33209

<400>   378
Val Thr Ile Ser Phe Met His Ala Met Ser Thr Gly Ala Leu Lys Thr 
                5                   10                  15      

Ser Leu Thr Lys Ile Thr Gln Asp Phe Met Ala Lys Asn Pro Asn Ile 
            20                  25                  30          

Thr Val Asp Leu Gln Glu Gln Pro Asp Tyr Ala Thr Leu Gln Thr Lys 
        35                  40                  45              

Ile Asn Ala Gln Thr Ala Ala Gly Thr Pro Pro Met Ile Ala Gln Val 
    50                  55                  60                  

Tyr Ser Asn Leu Ala Asp Glu Phe Ala Ser Ser Lys Val Ile Val Pro 
65                  70                  75                  80  

Leu Asp Asp Tyr Val Ser Gln Ser Lys Asp Tyr Gly Asn Phe Tyr Asp 
                85                  90                  95      

Gly Val Lys Lys Asp Leu Lys Leu Thr Asp Gly Lys Thr Arg Met Trp 
            100                 105                 110         

Pro Phe Asn Lys Ser Val Val Val Gln Tyr Tyr Asn Pro Thr Met Val 
        115                 120                 125             

Pro Glu Ala Pro Lys Thr Trp Asp Asp Phe Ala Thr Ala Ala Lys Lys 
    130                 135                 140                 

Ala Ser Thr Gly Asn Val Val Ala Leu Ser Ile Asp Pro Gly Asn Ser 
145                 150                 155                 160 

Ser Gly Pro Ala Gly Gly Thr Ala Leu Phe Glu Ile Met Ala Gln Ser 
                165                 170                 175     

Phe Gly Asp Pro Val Phe Ala Ser Asp Gly Thr Pro Gln Phe Thr Lys 
            180                 185                 190         

Asp Gly Val Val Lys Ala Leu Asp Tyr Leu Lys Gln Met Lys Lys Asp 
        195                 200                 205             

Gly Ser Leu Ala Leu Gly Thr Lys Tyr Pro Gly Gln Ala Ala Leu Gly 
    210                 215                 220                 

Gly Gln Thr Gly Ala Phe Asp Ile Ser Ser Val Ala Ser Tyr Gln Phe 
225                 230                 235                 240 

Asn Lys Ala Ala Val Gly Asp Lys Phe Ala Met Gly Val Ala Ala Leu 
                245                 250                 255     

Pro Ser Gly Pro Ala Gly Thr Ala Asn Gln Leu Ala Gly Thr Lys Ile 
            260                 265                 270         

Ala Leu Phe Asp Lys Ser Thr Asp Ala Gln Lys Ala Ala Ala Trp Lys 
        275                 280                 285             

Phe Met Gln Phe Leu Thr Ser Pro Glu Glu Met Ala Tyr Trp Ser Ser 
    290                 295                 300                 

Thr Thr Gly Tyr Leu Pro Val Ser Lys Asp Thr Leu Asp Gln Pro Val 
305                 310                 315                 320 

Phe Lys Asp Tyr Val Ala Lys Asn 
                325             

<210>   379
<211>   388
<212>   PRT
<213>   Clostridium difficile 630

<400>   379
Ser Asn Ile Thr Lys Ile Asp Phe Trp Ala Pro Leu Gly Gly Thr Asn 
                5                   10                  15      

Gly Glu Thr Ala Gln Lys Met Val Asp Gln Phe Asn Ser Glu His Lys 
            20                  25                  30          

Asp Val Gln Val Asn Met Leu Lys Gln Lys Asp Tyr Tyr Glu Asn Ala 
        35                  40                  45              

Thr Lys Leu Gln Ala Ala Leu Thr Ser Lys Asp Gln Pro Asp Val Thr 
    50                  55                  60                  

Leu Leu Glu Ile Thr Gln Thr Gly Thr Phe Ala Ser Ala Gly Ala Leu 
65                  70                  75                  80  

Val Asp Met Ser Lys Tyr Phe Asp Lys Thr Tyr Gln Glu Arg Phe Phe 
                85                  90                  95      

Ser Gly Leu Leu Thr Asn Ser Tyr Tyr Glu Asp Lys Phe Val Gly Met 
            100                 105                 110         

Pro Phe Asn Arg Ser Thr Pro Ile Leu Tyr Ile Asn Lys Asp Met Ala 
        115                 120                 125             

Thr Lys Ala Gly Leu Asp Pro Ser Gly Pro Lys Ser Trp Glu Glu Leu 
    130                 135                 140                 

Lys Asp Tyr Ala Ser Lys Met Thr Asn Lys Ser Glu Asp Thr Tyr Gly 
145                 150                 155                 160 

Phe Glu Thr Pro Ile Asp Ile Trp Phe Tyr Glu Ala Met Val Met Gln 
                165                 170                 175     

Ser Gly Gly Glu Ile Thr Asn Gly Lys Lys Val Ala Phe Asn Asn Glu 
            180                 185                 190         

Ala Gly Gln Ala Pro Val Lys Phe Trp Gln Asp Met Met Lys Ala Gly 
        195                 200                 205             

Ile Met Lys Met Pro Pro Gly Glu Asp Tyr Asn Ala Trp Asp Val Ala 
    210                 215                 220                 

Lys Gln Asp Phe Val Asn Gly Lys Val Gly Met Ile Phe Thr Ser Thr 
225                 230                 235                 240 

Ala Asp Leu Ala Gly Leu Met Gln Gln Thr Glu Gly Lys Phe Glu Ile 
                245                 250                 255     

Ser Thr Ala Phe Leu Pro Lys Asn Gln Lys Tyr Ala Thr Pro Thr Gly 
            260                 265                 270         

Gly Ala Asn Leu Val Met Leu Glu Gly Gly Thr Asp Lys Glu Lys Glu 
        275                 280                 285             

Ala Ser Ala Glu Phe Ile Glu Trp Met Thr Gln Thr Asp Lys Ile Val 
    290                 295                 300                 

Gln Phe Ser Ser Ser Thr Gly Tyr Leu Pro Thr Thr Glu Asp Ala Thr 
305                 310                 315                 320 

Asn Ser Glu Lys Leu Gln Thr Leu Tyr Lys Glu Lys Pro Gln Tyr Lys 
                325                 330                 335     

Val Ala Thr Asp Gln Leu Gln Tyr Ala Val Ala Leu Pro Met Leu Asn 
            340                 345                 350         

Gly Tyr Lys Glu Ala Thr Asp Lys Leu Met Asp Glu Ile Lys Lys Gly 
        355                 360                 365             

Leu Thr Asp Leu Asn Ala Asn Pro Lys Asp Val Val Ser Lys Gly Thr 
    370                 375                 380                 

Ser Ala Met Gln 
385             

<210>   380
<211>   388
<212>   PRT
<213>   Clostridium difficile QCD-32g58

<400>   380
Ser Asn Ile Thr Lys Ile Asp Phe Trp Ala Pro Leu Gly Gly Thr Asn 
                5                   10                  15      

Gly Glu Thr Ala Gln Lys Met Val Asp Gln Phe Asn Ser Glu His Lys 
            20                  25                  30          

Asp Val Gln Val Asn Met Leu Lys Gln Lys Asp Tyr Tyr Glu Asn Ala 
        35                  40                  45              

Thr Lys Leu Gln Ala Ala Leu Thr Ser Lys Asp Gln Pro Asp Val Thr 
    50                  55                  60                  

Leu Leu Glu Ile Thr Gln Thr Gly Thr Phe Ala Ser Ala Gly Ala Leu 
65                  70                  75                  80  

Val Asp Met Ser Lys Tyr Phe Asp Lys Thr Tyr Gln Glu Arg Phe Phe 
                85                  90                  95      

Ser Gly Leu Leu Thr Asn Ser Tyr Tyr Glu Asp Lys Phe Val Gly Met 
            100                 105                 110         

Pro Phe Asn Arg Ser Thr Pro Ile Leu Tyr Ile Asn Arg Asp Met Ala 
        115                 120                 125             

Thr Lys Ala Gly Leu Asp Pro Ser Gly Pro Lys Ser Trp Glu Glu Leu 
    130                 135                 140                 

Lys Asp Tyr Ala Ser Lys Met Thr Asn Lys Ser Glu Asp Thr Tyr Gly 
145                 150                 155                 160 

Phe Glu Thr Pro Ile Asp Ile Trp Phe Tyr Glu Ala Met Val Met Gln 
                165                 170                 175     

Ser Gly Gly Glu Ile Thr Asn Gly Lys Lys Val Ala Phe Asn Asn Glu 
            180                 185                 190         

Ala Gly Gln Ala Pro Val Lys Phe Trp Gln Asp Met Met Lys Ala Gly 
        195                 200                 205             

Ile Met Lys Met Pro Pro Gly Glu Asp Tyr Asn Ala Trp Asp Val Ala 
    210                 215                 220                 

Lys Gln Asp Phe Val Asn Gly Lys Val Gly Met Ile Phe Thr Ser Thr 
225                 230                 235                 240 

Ala Asp Leu Ala Gly Leu Met Gln Gln Thr Glu Gly Lys Phe Glu Ile 
                245                 250                 255     

Ser Thr Ala Phe Leu Pro Lys Asn Gln Lys Tyr Ala Thr Pro Thr Gly 
            260                 265                 270         

Gly Ala Asn Leu Val Met Leu Glu Gly Gly Thr Asp Lys Glu Lys Glu 
        275                 280                 285             

Ala Ser Ala Glu Phe Ile Glu Trp Met Thr Gln Thr Asp Lys Ile Val 
    290                 295                 300                 

Gln Phe Ser Ser Ser Thr Gly Tyr Leu Pro Thr Thr Glu Asp Ala Thr 
305                 310                 315                 320 

Asn Ser Glu Lys Leu Gln Thr Leu Tyr Lys Glu Lys Pro Gln Tyr Lys 
                325                 330                 335     

Val Ala Thr Asp Gln Leu Gln Tyr Ala Val Ala Leu Pro Met Leu Asn 
            340                 345                 350         

Gly Tyr Lys Glu Ala Thr Asp Lys Leu Met Asp Glu Ile Lys Lys Gly 
        355                 360                 365             

Leu Thr Asp Leu Asn Ala Asn Pro Lys Asp Val Val Ser Lys Gly Thr 
    370                 375                 380                 

Ser Ala Met Gln 
385             

<210>   381
<211>   389
<212>   PRT
<213>   Methylobacterium sp. 4-46

<400>   381
Gly Ala Leu Ala Arg Thr Met Thr Gly Leu Val Lys Glu Phe Asn Glu 
                5                   10                  15      

Ala His Pro Gly Thr Arg Val Thr Pro Val Phe Thr Gly Ser Tyr Asp 
            20                  25                  30          

Asp Thr Leu Leu Lys Thr Arg Ala Ala Ile Lys Ala Gly Lys Pro Pro 
        35                  40                  45              

Gly Ala Val Ile Met Ser Ala Asn Phe Leu Thr Asp Leu Ala Ile Glu 
    50                  55                  60                  

Arg Glu Ile Ala Pro Phe Asp Asp Leu Ile Ala Ala Glu Gly Gly Thr 
65                  70                  75                  80  

Pro Asp Ala Phe Met Asp Gln Phe Phe Pro Ala Leu Lys Gly Asn Ala 
                85                  90                  95      

Val Val Glu Arg Lys Val Tyr Gly Val Pro Phe His Asn Ser Thr Pro 
            100                 105                 110         

Leu Leu Tyr Tyr Asn Val Glu Gln Phe Arg Glu Ala Gly Leu Asp Pro 
        115                 120                 125             

Asp Ala Pro Pro Arg Thr Trp Asp Ala Leu Ala Ala Ala Ala Arg Lys 
    130                 135                 140                 

Leu Thr Arg Arg Glu Gly Gly Arg Val Thr Arg Trp Gly Ile Met Met 
145                 150                 155                 160 

Pro Ser Asn Tyr Asp Tyr Gly Gly Trp Ile Leu Gln Ala Leu Thr Leu 
                165                 170                 175     

Ser Asn Gly Gly Arg Trp Tyr Asn Glu Glu Tyr Gly Gly Glu Val Tyr 
            180                 185                 190         

Tyr Asp Thr Pro Thr Val Leu Gly Ala Leu Ser Phe Trp Ala Asp Leu 
        195                 200                 205             

Val His Arg Ala Lys Val His Pro Ala Gly Glu Ile Lys Gly Pro Ala 
    210                 215                 220                 

Val Thr Ala Ala Phe Leu Ser Gly Gln Ala Ala Met Met Ile Ile Ser 
225                 230                 235                 240 

Thr Gly Ser Leu Thr Phe Ile Arg Asp Ser Ala Lys Phe Pro Phe Arg 
                245                 250                 255     

Val Ala Phe Val Pro Met Asn Val Arg Pro Ala Val Pro Ile Gly Gly 
            260                 265                 270         

Ala Ser Leu Val Gln Pro Thr Gly Leu Asp Pro Glu Thr Arg Lys Ala 
        275                 280                 285             

Gly Trp Thr Leu Ile Arg Trp Leu Thr Ser Pro Ala Ile Ser Gly Arg 
    290                 295                 300                 

Trp Ser Arg Ala Thr Gly Tyr Phe Ala Pro Asn Arg Ala Ala Tyr Asp 
305                 310                 315                 320 

Leu Pro Glu Met Arg Ala Phe Leu Ala Gly Asn Pro Asp Ala Lys Ile 
                325                 330                 335     

Ala Val Asp Gln Leu Ala Asn Ala Lys Pro Trp Phe Ala Thr Tyr Arg 
            340                 345                 350         

Thr Val Pro Val Arg Lys Ala Ile Glu Asp Glu Leu Gln Ala Val Leu 
        355                 360                 365             

Ala Gly Lys Arg Gln Pro Lys Glu Ala Leu Ala Ala Ala Gln Thr Ser 
    370                 375                 380                 

Ala Asp Ala Ile Leu 
385                 

<210>   382
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   382
Met Val Leu Thr Gln Tyr Ser Ala Ile Gln Arg Gly Arg Ile His Val 
                5                   10                  15      

Arg Arg Ser Trp Val Leu Gly Thr Ala Ser Ala Val Ile Leu Ala Gly 
            20                  25                  30          

Ala Gly Thr Gly Val Ala Leu Asp Arg Gly His Ala His Asp Ala Val 
        35                  40                  45              

Arg Val Ala Pro Ala Glu Ala Ala Ser Ala Asn Gly Val Val Gln Ile 
    50                  55                  60                  

Thr Phe Trp Asn Gly His Pro Ser Gly Ala Leu Lys Lys Glu Met His 
65                  70                  75                  80  

Thr Leu Val Asp Glu Phe Asn Ala Thr His Pro His Ile His Val Thr 
                85                  90                  95      

Val Ile Asp Lys Tyr Ala Gln Ile Gln Pro Val Thr Ala Ala Met Thr 
            100                 105                 110         

Ala Gly Asp Ala Pro Asn Val Ile Met Pro His Leu Asp Ala Ala Gln 
        115                 120                 125             

Gln Phe Ala Ala Asp Gly Tyr Leu Val Asn Leu Thr Pro Tyr Ile Asp 
    130                 135                 140                 

Gly Pro Ser Gly Phe Thr Lys Ala Gln Leu Ser Ser Phe Phe Tyr Pro 
145                 150                 155                 160 

Ser Ile Trp Asn Gly Arg Ala Ile Glu Pro Gly Lys Gln Tyr Ile Leu 
                165                 170                 175     

Pro Phe Glu Glu Asn Gly His Met Val Ile Phe Tyr Asn Ala Asp Leu 
            180                 185                 190         

Phe Lys Lys Ala Gly Ile Ser Ser Pro Pro Lys Thr Trp Gln Gln Leu 
        195                 200                 205             

Arg Ala Asp Ala Arg Lys Ile Thr Ala Leu Gly Gly Ser Ile His Gly 
    210                 215                 220                 

Ile Ala Trp Thr Pro Ser Met Glu Gln Phe Leu Thr Met Val Ala Asp 
225                 230                 235                 240 

Asn Ser Gly Lys Ile Trp Ala Ser Ser Ser Glu Thr Arg Phe Ala Leu 
                245                 250                 255     

Asn Asn Pro Gln Ala Val Ala Thr Leu Ser Phe Leu Arg Asp Leu Val 
            260                 265                 270         

Ala Gln Gly Asp Met Ile Leu Thr Gln Asn Tyr Asp Tyr Gln Leu Asp 
        275                 280                 285             

Phe Gly Thr Gly Asn Ile Gly Leu Leu Ile Glu Ser Ser Ala Gly Trp 
    290                 295                 300                 

Thr Tyr Asp Val Gln Ser Val Gly Gly Lys Phe Pro Val Lys Ala Ser 
305                 310                 315                 320 

Pro Ala Pro Ala Gly Thr Ser Gly Arg Ala Tyr Asn Tyr Val Asp Gly 
                325                 330                 335     

Asp Ser Leu Ala Ile Leu Asn Thr Gly Thr Lys Ala Gln Gln Asp Ala 
            340                 345                 350         

Ala Trp Thr Phe Ile Arg Trp Leu Ala Ser Pro Ala Glu Asn Ala Gln 
        355                 360                 365             

Trp Asp Gln Ala Ala Asn Tyr Leu Pro Ile Gly Pro Ala Ala Ala Ala 
    370                 375                 380                 

Gln Leu Lys Pro Tyr Tyr Ala Ser His Pro Asp Gln Ala Ala Ala Phe 
385                 390                 395                 400 

Thr Asn Pro Ser Thr Trp Leu Thr Asp Pro Ala Ala Asn Ala Thr Gln 
                405                 410                 415     

Tyr Tyr Ala Ala Leu Thr Ala Met Gln Thr Glu Leu Leu Lys Ala Leu 
            420                 425                 430         

Asn Gly Gln Glu Ser Pro Gln Gln Ala Ile Ala Asn Met Asn Thr Val 
        435                 440                 445             

Gly Asn Gln Tyr Leu Ser Gly Glu Arg Arg Ser 
    450                 455                 

<210>   383
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   383
Met Val Leu Thr Gln Tyr Ser Ala Ile Gln Arg Gly Arg Ile His Val 
                5                   10                  15      

Arg Arg Ser Trp Val Leu Gly Thr Ala Ser Ala Val Ile Leu Ala Gly 
            20                  25                  30          

Ala Gly Thr Gly Val Ala Leu Asp Arg Gly His Ala His Asp Ala Val 
        35                  40                  45              

Arg Val Ala Pro Ala Glu Ala Ala Ser Ala Asn Gly Val Val Gln Ile 
    50                  55                  60                  

Thr Phe Trp Asn Gly His Pro Ser Gly Ala Leu Lys Lys Glu Met His 
65                  70                  75                  80  

Thr Leu Val Asp Glu Phe Asn Ala Thr His Pro His Ile His Val Thr 
                85                  90                  95      

Val Ile Asp Lys Tyr Ala Gln Ile Gln Pro Val Thr Ala Ala Met Thr 
            100                 105                 110         

Ala Gly Asp Ala Pro Asn Val Ile Met Pro His Leu Asp Ala Ala Gln 
        115                 120                 125             

Gln Phe Ala Ala Asp Gly Tyr Leu Val Asn Leu Thr Pro Tyr Ile Asp 
    130                 135                 140                 

Gly Pro Ser Gly Phe Thr Lys Ala Gln Leu Ser Ser Phe Phe Tyr Pro 
145                 150                 155                 160 

Ser Val Trp Asn Gly Arg Ala Ile Glu Pro Gly Lys Gln Tyr Ile Leu 
                165                 170                 175     

Pro Phe Glu Glu Asn Gly His Met Val Ile Phe Tyr Asn Ala Asp Leu 
            180                 185                 190         

Phe Lys Lys Ala Gly Ile Ser Ser Pro Pro Lys Thr Trp Gln Gln Leu 
        195                 200                 205             

Arg Ala Asp Ala Arg Lys Ile Thr Ala Leu Gly Gly Ser Ile His Gly 
    210                 215                 220                 

Ile Ala Trp Thr Pro Ser Met Glu Gln Phe Leu Thr Met Val Ala Asp 
225                 230                 235                 240 

Asn Ser Gly Lys Ile Trp Ala Ser Ser Ser Glu Thr Arg Phe Ala Leu 
                245                 250                 255     

Asn Asn Pro Gln Ala Val Ala Thr Leu Ser Phe Leu Arg Asp Leu Val 
            260                 265                 270         

Ala Gln Gly Asp Met Ile Leu Thr Gln Asn Tyr Asp Tyr Gln Leu Asp 
        275                 280                 285             

Phe Gly Thr Gly Asn Ile Gly Leu Leu Ile Glu Ser Ser Ala Gly Trp 
    290                 295                 300                 

Thr Tyr Asp Val Gln Ser Val Gly Gly Lys Phe Pro Val Lys Ala Ser 
305                 310                 315                 320 

Pro Ala Pro Ala Gly Thr Ser Gly Arg Ala Tyr Asn Tyr Val Asp Gly 
                325                 330                 335     

Asp Ser Leu Ala Ile Leu Asn Thr Gly Thr Lys Ala Gln Gln Asp Ala 
            340                 345                 350         

Ala Trp Thr Phe Ile Arg Trp Leu Ala Ser Pro Ala Glu Asn Ala Gln 
        355                 360                 365             

Trp Glu Gln Ala Ala Asn Tyr Leu Pro Ile Gly Pro Ala Ala Ala Ala 
    370                 375                 380                 

Gln Leu Lys Pro Tyr Tyr Ala Ser His Pro Asp Gln Ala Ala Ala Phe 
385                 390                 395                 400 

Thr Asn Pro Ser Thr Trp Leu Thr Asp Pro Ala Ala Asn Ala Thr Gln 
                405                 410                 415     

Tyr Tyr Ala Ala Leu Thr Ala Met Gln Thr Glu Leu Leu Lys Ala Leu 
            420                 425                 430         

Asn Gly Gln Glu Ser Pro Gln Gln Ala Ile Ala Asn Met Asn Thr Val 
        435                 440                 445             

Gly Asn Gln Tyr Leu Ser Gly Glu Arg Arg Ser 
    450                 455                 

<210>   384
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   384
Met Val Leu Thr Gln Tyr Ser Ala Ile Gln Arg Gly Arg Ile His Val 
                5                   10                  15      

Arg Arg Ser Trp Val Leu Gly Thr Ala Ser Ala Val Ile Leu Ala Gly 
            20                  25                  30          

Ala Gly Thr Gly Val Ala Leu Asp Arg Gly His Ala His Asp Ala Val 
        35                  40                  45              

Arg Val Ala Pro Ala Glu Ala Ala Ser Ala Asn Gly Val Val Gln Ile 
    50                  55                  60                  

Thr Phe Trp Asn Gly His Pro Ser Gly Ala Leu Lys Lys Glu Met His 
65                  70                  75                  80  

Thr Leu Val Asp Glu Phe Asn Ala Thr His Pro His Ile His Val Thr 
                85                  90                  95      

Val Ile Asp Lys Tyr Ala Gln Ile Gln Pro Val Thr Ala Ala Met Thr 
            100                 105                 110         

Ala Gly Asp Ala Pro Asn Val Ile Met Pro His Leu Asp Ala Ala Gln 
        115                 120                 125             

Gln Phe Ala Ala Asp Gly Tyr Leu Val Asn Leu Thr Pro Tyr Ile Asp 
    130                 135                 140                 

Gly Pro Ser Gly Phe Thr Lys Ala Gln Leu Ser Ser Phe Phe Tyr Pro 
145                 150                 155                 160 

Ser Val Trp Asn Gly Arg Ala Ile Glu Pro Gly Lys Gln Tyr Ile Leu 
                165                 170                 175     

Pro Phe Glu Glu Asn Gly His Met Val Ile Phe Tyr Asn Ala Asp Leu 
            180                 185                 190         

Phe Lys Lys Ala Gly Ile Ser Ser Pro Pro Lys Thr Trp Gln Gln Leu 
        195                 200                 205             

Arg Ala Asp Ala Arg Lys Ile Thr Ala Leu Gly Gly Ser Ile His Gly 
    210                 215                 220                 

Ile Ala Trp Thr Pro Ser Met Glu Gln Phe Leu Thr Met Val Ala Asp 
225                 230                 235                 240 

Asn Ser Gly Lys Ile Trp Ala Ser Ser Ser Glu Thr Arg Phe Ala Leu 
                245                 250                 255     

Asn Asn Pro Gln Ala Val Ala Thr Leu Ser Phe Leu Arg Asp Leu Val 
            260                 265                 270         

Ala Gln Gly Asp Met Ile Leu Thr Gln Asn Tyr Asp Tyr Gln Leu Asp 
        275                 280                 285             

Phe Gly Thr Gly Asn Ile Gly Leu Leu Ile Glu Ser Ser Ala Gly Trp 
    290                 295                 300                 

Thr Tyr Asp Val Gln Ser Val Gly Gly Lys Phe Pro Val Lys Ala Ser 
305                 310                 315                 320 

Pro Ala Pro Ala Gly Thr Ser Gly Arg Ala Tyr Asn Tyr Val Asp Gly 
                325                 330                 335     

Asp Ser Leu Ala Ile Leu Asn Thr Gly Thr Lys Ala Gln Gln Asp Ala 
            340                 345                 350         

Ala Trp Thr Phe Ile Arg Trp Leu Ala Ser Pro Ala Glu Asn Ala Gln 
        355                 360                 365             

Trp Asp Gln Ala Ala Asn Tyr Leu Pro Ile Gly Pro Ala Ala Ala Ala 
    370                 375                 380                 

Gln Leu Lys Pro Tyr Tyr Ala Ser His Pro Asp Gln Ala Ala Ala Phe 
385                 390                 395                 400 

Thr Asn Pro Ser Thr Trp Leu Thr Asp Pro Ala Ala Asn Ala Thr Gln 
                405                 410                 415     

Tyr Tyr Ala Ala Leu Thr Ala Met Gln Thr Glu Leu Leu Lys Ala Leu 
            420                 425                 430         

Asn Gly Gln Glu Ser Pro Gln Gln Ala Ile Ala Asn Met Asn Thr Val 
        435                 440                 445             

Gly Asn Gln Tyr Leu Ser Gly Asp Arg Arg Ser 
    450                 455                 

<210>   385
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   385
Met Val Leu Thr Gln Tyr Ser Ala Ile Gln Arg Gly Arg Ile His Val 
                5                   10                  15      

Arg Arg Ser Trp Val Leu Gly Thr Ala Ser Ala Val Ile Leu Ala Gly 
            20                  25                  30          

Ala Gly Thr Gly Val Ala Leu Asp Arg Gly His Ala His Asp Ala Val 
        35                  40                  45              

Arg Val Ala Pro Ala Glu Ala Ala Ser Ala Asn Gly Val Val Gln Ile 
    50                  55                  60                  

Thr Phe Trp Asn Gly His Pro Ser Gly Ala Leu Lys Lys Glu Met His 
65                  70                  75                  80  

Thr Leu Val Asp Glu Phe Asn Ala Thr His Pro His Ile His Val Thr 
                85                  90                  95      

Val Ile Asp Lys Tyr Ala Gln Ile Gln Pro Val Thr Ala Ala Met Thr 
            100                 105                 110         

Ala Gly Asp Ala Pro Asn Val Ile Met Pro His Leu Asp Ala Ala Gln 
        115                 120                 125             

Gln Phe Ala Ala Asp Gly Tyr Leu Val Asn Leu Thr Pro Tyr Ile Asp 
    130                 135                 140                 

Gly Pro Ser Gly Phe Thr Lys Ala Gln Leu Ser Ser Phe Phe Tyr Pro 
145                 150                 155                 160 

Ser Val Trp Asn Gly Arg Ala Ile Glu Pro Gly Lys Gln Tyr Ile Leu 
                165                 170                 175     

Pro Phe Glu Glu Asn Gly His Met Val Ile Phe Tyr Asn Ala Asp Leu 
            180                 185                 190         

Phe Lys Lys Ala Gly Ile Ser Ser Pro Pro Lys Thr Trp Gln Gln Leu 
        195                 200                 205             

Arg Ala Asp Ala Arg Lys Ile Thr Ala Leu Gly Gly Ser Ile His Gly 
    210                 215                 220                 

Ile Ala Trp Thr Pro Ser Met Glu Gln Phe Leu Thr Met Val Ala Asp 
225                 230                 235                 240 

Asn Ser Gly Lys Ile Trp Ala Ser Ser Ser Glu Thr Arg Phe Ala Leu 
                245                 250                 255     

Asn Asn Pro Gln Ala Val Ala Thr Leu Ser Phe Leu Arg Asp Leu Val 
            260                 265                 270         

Ala Gln Gly Asp Met Ile Leu Thr Gln Asn Tyr Asp Tyr Gln Leu Asp 
        275                 280                 285             

Phe Gly Thr Gly Asn Ile Gly Leu Leu Ile Glu Ser Ser Ala Gly Trp 
    290                 295                 300                 

Thr Tyr Asp Val Gln Ser Val Gly Gly Lys Phe Pro Val Lys Ala Ser 
305                 310                 315                 320 

Pro Ala Pro Ala Gly Thr Ser Gly Arg Ala Tyr Asn Tyr Val Asp Gly 
                325                 330                 335     

Asp Ser Leu Ala Ile Ile Asn Thr Gly Thr Lys Ala Gln Gln Asp Ala 
            340                 345                 350         

Ala Trp Thr Phe Ile Arg Trp Leu Ala Ser Pro Ala Glu Asn Ala Gln 
        355                 360                 365             

Trp Asp Gln Ala Ala Asn Tyr Leu Pro Ile Gly Pro Ala Ala Ala Ala 
    370                 375                 380                 

Gln Leu Lys Pro Tyr Tyr Ala Ser His Pro Asp Gln Ala Ala Ala Phe 
385                 390                 395                 400 

Thr Asn Pro Ser Thr Trp Leu Thr Asp Pro Ala Ala Asn Ala Thr Gln 
                405                 410                 415     

Tyr Tyr Ala Ala Leu Thr Ala Met Gln Thr Glu Leu Leu Lys Ala Leu 
            420                 425                 430         

Asn Gly Gln Glu Ser Pro Gln Gln Ala Ile Ala Asn Met Asn Thr Val 
        435                 440                 445             

Gly Asn Gln Tyr Leu Ser Gly Glu Arg Arg Ser 
    450                 455                 

<210>   386
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 375

<400>   386
Met Val Leu Thr Gln Tyr Ser Ala Ile Gln Arg Gly Arg Ile His Val 
                5                   10                  15      

Arg Arg Ser Trp Val Leu Gly Thr Ala Ser Ala Val Ile Leu Ala Gly 
            20                  25                  30          

Ala Gly Thr Gly Val Ala Ile Asp Arg Gly His Ala His Asp Ala Val 
        35                  40                  45              

Arg Val Ala Pro Ala Glu Ala Ala Ser Ala Asn Gly Val Val Gln Ile 
    50                  55                  60                  

Thr Phe Trp Asn Gly His Pro Ser Gly Ala Leu Lys Lys Glu Met His 
65                  70                  75                  80  

Thr Leu Val Asp Glu Phe Asn Ala Thr His Pro His Ile His Val Thr 
                85                  90                  95      

Val Ile Asp Lys Tyr Ala Gln Ile Gln Pro Val Thr Ala Ala Met Thr 
            100                 105                 110         

Ala Gly Asp Ala Pro Asn Val Ile Met Pro His Leu Asp Ala Ala Gln 
        115                 120                 125             

Gln Phe Ala Ala Asp Gly Tyr Leu Val Asn Leu Thr Pro Tyr Ile Asp 
    130                 135                 140                 

Gly Pro Ser Gly Phe Thr Lys Ala Gln Leu Ser Ser Phe Phe Tyr Pro 
145                 150                 155                 160 

Ser Val Trp Asn Gly Arg Ala Ile Glu Pro Gly Lys Gln Tyr Ile Leu 
                165                 170                 175     

Pro Phe Glu Glu Asn Gly His Met Val Ile Phe Tyr Asn Ala Asp Leu 
            180                 185                 190         

Phe Lys Lys Ala Gly Ile Ser Ser Pro Pro Lys Thr Trp Gln Gln Leu 
        195                 200                 205             

Arg Ala Asp Ala Arg Lys Ile Thr Ala Leu Gly Gly Ser Ile His Gly 
    210                 215                 220                 

Ile Ala Trp Thr Pro Ser Met Glu Gln Phe Leu Thr Met Val Ala Asp 
225                 230                 235                 240 

Asn Ser Gly Lys Ile Trp Ala Ser Ser Ser Glu Thr Arg Phe Ala Leu 
                245                 250                 255     

Asn Asn Pro Gln Ala Val Ala Thr Leu Ser Phe Leu Arg Asp Leu Val 
            260                 265                 270         

Ala Gln Gly Asp Met Ile Leu Thr Gln Asn Tyr Asp Tyr Gln Leu Asp 
        275                 280                 285             

Phe Gly Thr Gly Asn Ile Gly Leu Leu Ile Glu Ser Ser Ala Gly Trp 
    290                 295                 300                 

Thr Tyr Asp Val Gln Ser Val Gly Gly Lys Phe Pro Val Lys Ala Ser 
305                 310                 315                 320 

Pro Ala Pro Ala Gly Thr Ser Gly Arg Ala Tyr Asn Tyr Val Asp Gly 
                325                 330                 335     

Asp Ser Leu Ala Ile Leu Asn Thr Gly Thr Lys Ala Gln Gln Asp Ala 
            340                 345                 350         

Ala Trp Thr Phe Ile Arg Trp Leu Ala Ser Pro Ala Glu Asn Ala Gln 
        355                 360                 365             

Trp Asp Gln Ala Ala Asn Tyr Leu Pro Ile Gly Pro Ala Ala Ala Ala 
    370                 375                 380                 

Gln Leu Lys Pro Tyr Tyr Ala Ser His Pro Asp Gln Ala Ala Ala Phe 
385                 390                 395                 400 

Thr Asn Pro Ser Thr Trp Leu Thr Asp Pro Ala Ala Asn Ala Thr Gln 
                405                 410                 415     

Tyr Tyr Ala Ala Leu Thr Ala Met Gln Thr Glu Leu Leu Lys Ala Leu 
            420                 425                 430         

Asn Gly Gln Glu Ser Pro Gln Gln Ala Ile Ala Asn Met Asn Thr Val 
        435                 440                 445             

Gly Asn Gln Tyr Leu Ser Gly Glu Arg Arg Ser 
    450                 455                 

<210>   387
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   387
atggtcttga cccaatattc ggccattcaa agggggagaa ttcacgtgag acgaagctgg       60

gttctcggca ccgcatccgc cgtgatcttg gcgggcgcgg gaaccggtgt ggcactcgat      120

cgcgggcacg cgcacgacgc ggttcgcgtg gcgcctgcgg aagcggcgag cgcaaacgga      180

gtcgttcaga tcacattttg gaacgggcat ccttctggcg cgctgaagaa ggagatgcac      240

acccttgtcg acgagttcaa cgccacccat cctcacatcc atgtcacggt tatcgacaag      300

tacgcgcaga ttcagcccgt caccgccgca atgaccgctg gcgatgcgcc gaacgtgatc      360

atgcctcacc tcgatgccgc tcagcagttc gcggcagacg gctacctcgt gaacctgacg      420

ccgtacatcg acggaccgag cggtttcacg aaggctcaac tctcctcgtt cttctatccc      480

tctatttgga acggccgcgc catcgagccg ggcaaacaat acatcctccc gttcgaagaa      540

aacgggcata tggtaatctt ctacaacgcg gatctgttca agaaggcggg catctcgtcg      600

ccgcccaaga cgtggcagca gctcagggcg gatgcgcgga agatcacggc gctcggcgga      660

agcatccacg gcattgcatg gaccccctcc atggagcaat tcctgacgat ggtcgcagac      720

aacagcggaa agatttgggc atccagcagc gagacgcggt tcgccctgaa caacccgcag      780

gccgtcgcca ccctctcctt tttgcgcgat ctcgtcgcgc agggcgacat gatcctcacc      840

caaaactacg actatcaatt ggattttggc acgggcaaca tcggtttgct catcgaatcg      900

tccgcagggt ggacctatga cgtgcagtcg gtcggcggca agttcccggt caaagcgtcc      960

ccggcgcccg ctggcacgtc cggccgcgcg tacaactacg tcgacggcga cagcctcgcc     1020

attttgaaca cgggaaccaa ggcgcagcag gatgcggcgt ggacgttcat tcgctggctc     1080

gcgagccccg cggaaaacgc gcagtgggat caggcggcga attaccttcc catcggaccc     1140

gctgcagcag cccagctgaa accgtactat gcttcccatc ccgaccaggc ggccgccttc     1200

acgaatccat ccacatggct gacggatccg gccgcgaacg cgacgcaata ctacgccgcg     1260

ctgaccgcca tgcagactga actgctgaag gcgctcaacg ggcaggaatc gccgcaacag     1320

gccatcgcga acatgaatac cgtcggcaat caatacctga gcggcgagcg caggagctga     1380

                                                                      1380


<210>   388
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   388
atggtcttga cccaatattc ggccattcaa agggggagaa ttcacgtgag acgaagctgg       60

gttctcggca ccgcatccgc cgtgatcttg gcgggcgcgg gaaccggtgt ggcactcgat      120

cgcgggcacg cgcacgacgc ggttcgcgtg gcgcctgcgg aagcggcgag cgcaaacgga      180

gtcgttcaga tcacattttg gaacgggcat ccttctggcg cgctgaagaa ggagatgcac      240

acccttgtcg acgagttcaa cgccacccat cctcacatcc atgtcacggt tatcgacaag      300

tacgcgcaga ttcagcccgt caccgccgca atgaccgctg gcgatgcgcc gaacgtgatc      360

atgcctcacc tcgatgccgc tcagcagttc gcggcagacg gctacctcgt gaacctgacg      420

ccgtacatcg acggaccgag cggtttcacg aaggctcaac tctcctcgtt cttctatccc      480

tctgtctgga acggccgcgc catcgagccg ggcaaacaat acatcctccc gttcgaagaa      540

aacgggcata tggtaatctt ctacaacgcg gatctgttca agaaggcggg catctcgtcg      600

ccgcccaaga cgtggcagca gctcagggcg gatgcgcgga agatcacggc gctcggcgga      660

agcatccacg gcattgcatg gaccccctcc atggagcaat tcctgacgat ggtcgcagac      720

aacagcggaa agatttgggc atccagcagc gagacgcggt tcgccctgaa caacccgcag      780

gccgtcgcca ccctctcctt tttgcgcgat ctcgtcgcgc agggcgacat gatcctcacc      840

caaaactacg actatcaatt ggattttggc acgggcaaca tcggtttgct catcgaatcg      900

tccgcagggt ggacctatga cgtgcagtcg gtcggcggca agttcccggt caaagcgtcc      960

ccggcgcccg ctggcacgtc cggccgcgcg tacaactacg tcgacggcga cagcctcgcc     1020

attttgaaca cgggaaccaa ggcgcagcag gatgcggcgt ggacgttcat tcgctggctc     1080

gcgagccccg cggaaaacgc gcagtgggaa caggcggcga attaccttcc catcggaccc     1140

gctgcagcag cccagctgaa accgtactat gcttcccatc ccgaccaggc ggccgccttc     1200

acgaatccat ccacatggct gacggatccg gccgcgaacg cgacgcaata ctacgccgcg     1260

ctgaccgcca tgcagactga actgctgaag gcgctcaacg ggcaggaatc gccgcaacag     1320

gccatcgcga acatgaatac cgtcggcaat caatacctga gcggcgagcg caggagctga     1380

                                                                      1380


<210>   389
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   389
atggtcttga cccaatattc ggccattcaa agggggagaa ttcacgtgag acgaagctgg       60

gttctcggca ccgcatccgc cgtgatcttg gcgggcgcgg gaaccggtgt ggcactcgat      120

cgcgggcacg cgcacgacgc ggttcgcgtg gcgcctgcgg aagcggcgag cgcaaacgga      180

gtcgttcaga tcacattttg gaacgggcat ccttctggcg cgctgaagaa ggagatgcac      240

acccttgtcg acgagttcaa cgccacccat cctcacatcc atgtcacggt tatcgacaag      300

tacgcgcaga ttcagcccgt caccgccgca atgaccgctg gcgatgcgcc gaacgtgatc      360

atgcctcacc tcgatgccgc tcagcagttc gcggcagacg gctacctcgt gaacctgacg      420

ccgtacatcg acggaccgag cggtttcacg aaggctcaac tctcctcgtt cttctatccc      480

tctgtctgga acggccgcgc catcgagccg ggcaaacaat acatcctccc gttcgaagaa      540

aacgggcata tggtaatctt ctacaacgcg gatctgttca agaaggcggg catctcgtcg      600

ccgcccaaga cgtggcagca gctcagggcg gatgcgcgga agatcacggc gctcggcgga      660

agcatccacg gcattgcatg gaccccctcc atggagcaat tcctgacgat ggtcgcagac      720

aacagcggaa agatttgggc atccagcagc gagacgcggt tcgccctgaa caacccgcag      780

gccgtcgcca ccctctcctt tttgcgcgat ctcgtcgcgc agggcgacat gatcctcacc      840

caaaactacg actatcaatt ggattttggc acgggcaaca tcggtttgct catcgaatcg      900

tccgcagggt ggacctatga cgtgcagtcg gtcggcggca agttcccggt caaagcgtcc      960

ccggcgcccg ctggcacgtc cggccgcgcg tacaactacg tcgacggcga cagcctcgcc     1020

attttgaaca cgggaaccaa ggcgcagcag gatgcggcgt ggacgttcat tcgctggctc     1080

gcgagccccg cggaaaacgc gcagtgggat caggcggcga attaccttcc catcggaccc     1140

gctgcagcag cccagctgaa accgtactat gcttcccatc ccgaccaggc ggccgccttc     1200

acgaatccat ccacatggct gacggatccg gccgcgaacg cgacgcaata ctacgccgcg     1260

ctgaccgcca tgcagactga actgctgaag gcgctcaacg ggcaggaatc gccgcaacag     1320

gccatcgcga acatgaatac cgtcggcaat caatacctga gcggcgatcg caggagctga     1380

                                                                      1380


<210>   390
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   390
atggtcttga cccaatattc ggccattcaa agggggagaa ttcacgtgag acgaagctgg       60

gttctcggca ccgcatccgc cgtgatcttg gcgggcgcgg gaaccggtgt ggcactcgat      120

cgcgggcacg cgcacgacgc ggttcgcgtg gcgcctgcgg aagcggcgag cgcaaacgga      180

gtcgttcaga tcacattttg gaacgggcat ccttctggcg cgctgaagaa ggagatgcac      240

acccttgtcg acgagttcaa cgccacccat cctcacatcc atgtcacggt tatcgacaag      300

tacgcgcaga ttcagcccgt caccgccgca atgaccgctg gcgatgcgcc gaacgtgatc      360

atgcctcacc tcgatgccgc tcagcagttc gcggcagacg gctacctcgt gaacctgacg      420

ccgtacatcg acggaccgag cggtttcacg aaggctcaac tctcctcgtt cttctatccc      480

tctgtctgga acggccgcgc catcgagccg ggcaaacaat acatcctccc gttcgaagaa      540

aacgggcata tggtaatctt ctacaacgcg gatctgttca agaaggcggg catctcgtcg      600

ccgcccaaga cgtggcagca gctcagggcg gatgcgcgga agatcacggc gctcggcgga      660

agcatccacg gcattgcatg gaccccctcc atggagcaat tcctgacgat ggtcgcagac      720

aacagcggaa agatttgggc atccagcagc gagacgcggt tcgccctgaa caacccgcag      780

gccgtcgcca ccctctcctt tttgcgcgat ctcgtcgcgc agggcgacat gatcctcacc      840

caaaactacg actatcaatt ggattttggc acgggcaaca tcggtttgct catcgaatcg      900

tccgcagggt ggacctatga cgtgcagtcg gtcggcggca agttcccggt caaagcgtcc      960

ccggcgcccg ctggcacgtc cggccgcgcg tacaactacg tcgacggcga cagcctcgcc     1020

attattaaca cgggaaccaa ggcgcagcag gatgcggcgt ggacgttcat tcgctggctc     1080

gcgagccccg cggaaaacgc gcagtgggat caggcggcga attaccttcc catcggaccc     1140

gctgcagcag cccagctgaa accgtactat gcttcccatc ccgaccaggc ggccgccttc     1200

acgaatccat ccacatggct gacggatccg gccgcgaacg cgacgcaata ctacgccgcg     1260

ctgaccgcca tgcagactga actgctgaag gcgctcaacg ggcaggaatc gccgcaacag     1320

gccatcgcga acatgaatac cgtcggcaat caatacctga gcggcgagcg caggagctga     1380

                                                                      1380


<210>   391
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 376

<400>   391
atggtcttga cccaatattc ggccattcaa agggggagaa ttcacgtgag acgaagctgg       60

gttctcggca ccgcatccgc cgtgatcttg gcgggcgcgg gaaccggtgt ggcaattgat      120

cgcgggcacg cgcacgacgc ggttcgcgtg gcgcctgcgg aagcggcgag cgcaaacgga      180

gtcgttcaga tcacattttg gaacgggcat ccttctggcg cgctgaagaa ggagatgcac      240

acccttgtcg acgagttcaa cgccacccat cctcacatcc atgtcacggt tatcgacaag      300

tacgcgcaga ttcagcccgt caccgccgca atgaccgctg gcgatgcgcc gaacgtgatc      360

atgcctcacc tcgatgccgc tcagcagttc gcggcagacg gctacctcgt gaacctgacg      420

ccgtacatcg acggaccgag cggtttcacg aaggctcaac tctcctcgtt cttctatccc      480

tctgtctgga acggccgcgc catcgagccg ggcaaacaat acatcctccc gttcgaagaa      540

aacgggcata tggtaatctt ctacaacgcg gatctgttca agaaggcggg catctcgtcg      600

ccgcccaaga cgtggcagca gctcagggcg gatgcgcgga agatcacggc gctcggcgga      660

agcatccacg gcattgcatg gaccccctcc atggagcaat tcctgacgat ggtcgcagac      720

aacagcggaa agatttgggc atccagcagc gagacgcggt tcgccctgaa caacccgcag      780

gccgtcgcca ccctctcctt tttgcgcgat ctcgtcgcgc agggcgacat gatcctcacc      840

caaaactacg actatcaatt ggattttggc acgggcaaca tcggtttgct catcgaatcg      900

tccgcagggt ggacctatga cgtgcagtcg gtcggcggca agttcccggt caaagcgtcc      960

ccggcgcccg ctggcacgtc cggccgcgcg tacaactacg tcgacggcga cagcctcgcc     1020

attttgaaca cgggaaccaa ggcgcagcag gatgcggcgt ggacgttcat tcgctggctc     1080

gcgagccccg cggaaaacgc gcagtgggat caggcggcga attaccttcc catcggaccc     1140

gctgcagcag cccagctgaa accgtactat gcttcccatc ccgaccaggc ggccgccttc     1200

acgaatccat ccacatggct gacggatccg gccgcgaacg cgacgcaata ctacgccgcg     1260

ctgaccgcca tgcagactga actgctgaag gcgctcaacg ggcaggaatc gccgcaacag     1320

gccatcgcga acatgaatac cgtcggcaat caatacctga gcggcgagcg caggagctga     1380

                                                                      1380


<210>   392
<211>   289
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   392
Met Arg Gly Leu Trp Gln Ser Gly Arg Arg Arg Glu Gly Leu Arg Leu 
                5                   10                  15      

Met Arg Arg Ile Leu Thr Ile Leu Ala Ala Tyr Phe Val Leu Ala Val 
            20                  25                  30          

Gly Ala Phe Ile Ser Ile Phe Pro Tyr Leu Trp Ala Val Leu Thr Ser 
        35                  40                  45              

Leu Lys Pro Glu Ser Glu Val Phe Thr Ser His Phe Leu Ser Leu Pro 
    50                  55                  60                  

Thr His Ile Glu Trp Ala Asn Tyr Thr His Val Phe Gln Gln Ile Asn 
65                  70                  75                  80  

Met Gly Arg Tyr Leu Leu Asn Thr Val Ile Val Ala Val Ala Ser Val 
                85                  90                  95      

Leu Gly Gln Leu Ile Phe Gly Ser Met Ala Ala Tyr Gly Phe Ser Arg 
            100                 105                 110         

Phe Asn Phe Lys Gly Lys Asn Val Ile Phe Met Leu Tyr Leu Ser Thr 
        115                 120                 125             

Leu Met Ile Pro Asn Ile Val Thr Leu Ile Pro Leu Phe Ile Met Met 
    130                 135                 140                 

Lys Tyr Leu Gly Trp Ile Asn Thr Tyr Tyr Ala Leu Ile Ala Pro Ala 
145                 150                 155                 160 

Ala Leu Gly Thr Pro Val Gly Ile Phe Leu Leu Arg Gln Phe Phe Leu 
                165                 170                 175     

Thr Ile Pro Ser Glu Ile Glu Glu Ala Ala Arg Met Asp Gly Ala Gly 
            180                 185                 190         

Val Ile Arg Val Phe Val Gln Ile Ile Leu Pro Leu Ser Lys Pro Val 
        195                 200                 205             

Leu Ala Thr Leu Ala Ile Ile Thr Phe Val Ser Ser Trp Asn Asn Phe 
    210                 215                 220                 

Leu Trp Pro Leu Ile Val Thr Asn Thr Asp Ser Met Lys Leu Val Ser 
225                 230                 235                 240 

Val Gly Ile Ala Ser Phe Gln Phe Gln Val Gly Ala Glu Trp Asn Tyr 
                245                 250                 255     

Met Met Ala Ala Ser Thr Ile Ala Leu Leu Pro Leu Val Ile Leu Phe 
            260                 265                 270         

Leu Leu Phe Gln Arg Arg Ile Ile Glu Ser Ile Gln Leu Thr Gly Leu 
        275                 280                 285             

Lys 
    

<210>   393
<211>   870
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   393
ttgcggggct tgtggcagtc tggccgccgg agggagggac ttcggcttat gaggcgaatt       60

cttacgattc ttgctgctta cttcgtcctc gctgtaggtg cattcatatc catatttccg      120

tatctgtggg ccgtacttac ttctttgaag cctgaaagcg aggtcttcac atctcacttt      180

ttgagtctgc cgactcacat cgaatgggcc aactataccc atgtatttca acagattaac      240

atggggcgat acttactgaa caccgtgatt gtggcagttg cgagcgtgct aggccagctc      300

attttcggtt ctatggctgc ctatggattt tcgcggttta actttaaggg gaagaatgta      360

atattcatgc tttatttaag tacgctcatg atccccaaca tcgtaacact cattcctcta      420

tttatcatga tgaaatatct ggggtggatc aacacctact atgcactcat tgcgccagct      480

gcgctcggga ctccggtggg catatttctg ttgagacaat ttttcctaac tattccctct      540

gagattgaag aagccgctcg aatggacgga gcaggtgtca ttcgagtatt cgtacaaatc      600

atcttgcctt taagcaaacc ggttctagcg actttggcaa tcattacgtt cgtgtcgtca      660

tggaacaact ttctatggcc cctcattgtg acgaataccg actctatgaa gcttgtgagt      720

gtaggcattg cctcgtttca atttcaagta ggtgcagaat ggaactacat gatggctgct      780

tccacaatag ccctgctccc attggtcatc ctattcttgc tgtttcagcg caggattatc      840

gagtcaattc agctcactgg gttgaagtag                                       870


<210>   394
<211>   265
<212>   PRT
<213>   Deinococcus geothermalis DSM 11300

<400>   394
Leu Leu Leu Thr His Gly Val Leu Leu Phe Gly Ala Phe Leu Ala Ala 
                5                   10                  15      

Met Pro Phe Leu Trp Val Ile Thr Thr Ser Leu Lys Pro Asn Gly Ala 
            20                  25                  30          

Leu Tyr Gln Pro Pro Leu Leu Leu Pro Thr His Phe Glu Trp Glu Asn 
        35                  40                  45              

Tyr Arg Lys Ala Trp Glu Ala Ala Pro Phe Pro Arg Phe Phe Leu Asn 
    50                  55                  60                  

Ser Ala Val Met Thr Val Ala Leu Thr Val Ser Gln Thr Leu Leu Ser 
65                  70                  75                  80  

Ala Met Ala Gly Tyr Ala Phe Ala Arg Leu Arg Phe Pro Gly Arg Asn 
                85                  90                  95      

Leu Leu Phe Phe Ile Val Leu Gly Thr Leu Met Ile Pro Phe Pro Val 
            100                 105                 110         

Thr Leu Ile Pro Asn Phe Leu Thr Val Asn Ala Leu Gly Trp Val Asp 
        115                 120                 125             

Thr Tyr Gln Ala Leu Ile Ile Pro Arg Ala Val Ser Ala Phe Ala Ile 
    130                 135                 140                 

Phe Leu Phe Arg Gln Phe Phe Leu Ser Ile Pro Lys Glu Leu Glu Glu 
145                 150                 155                 160 

Ala Ala Arg Ile Asp Gly Ala Ser Pro Phe Thr Ile Phe Trp Arg Ile 
                165                 170                 175     

Val Leu Pro Leu Ser Thr Pro Val Leu Ala Ala Ser Ala Ile Phe Ser 
            180                 185                 190         

Phe Leu Phe Ala Trp Asn Asp Phe Leu Trp Pro Leu Ile Ile Thr Asn 
        195                 200                 205             

Ser Thr Glu Met Arg Thr Val Gln Val Gly Leu Ala Thr Phe Gln Gly 
    210                 215                 220                 

Gln Tyr Gly Ile Phe Trp Thr Leu Leu Cys Ala Ala Thr Val Ile Val 
225                 230                 235                 240 

Thr Leu Pro Ala Leu Leu Ala Phe Leu Ala Ala Gln Arg Arg Phe Ile 
                245                 250                 255     

Glu Gly Ile Thr Ser Thr Gly Leu Lys 
            260                 265 

<210>   395
<211>   262
<212>   PRT
<213>   Halothermothrix orenii H 168

<400>   395
Tyr Phe Ile Leu Leu Phe Phe Leu Val Ile Thr Leu Tyr Pro Phe Ile 
                5                   10                  15      

Trp Met Val Leu Thr Ser Phe Lys Ile Glu Ser Asp Ile Val Ser Tyr 
            20                  25                  30          

Pro Pro Thr Leu Ile Pro Arg Thr Phe Thr Leu Lys Ser Tyr Leu Asn 
        35                  40                  45              

Ile Trp Lys Ser Ile Pro Phe Val Arg Phe Phe Ile Asn Thr Val Ile 
    50                  55                  60                  

Phe Ala Val Gly Val Thr Val Ile Ser Val Phe Phe Asp Ser Met Ala 
65                  70                  75                  80  

Ala Tyr Ala Phe Ala Arg Ile Asn Phe Pro Gly Lys Lys Phe Leu Phe 
                85                  90                  95      

Ile Leu Val Leu Ala Thr Leu Met Val Pro Phe Gln Val Thr Leu Ile 
            100                 105                 110         

Pro Val Phe Lys Ile Leu Phe Asn Leu Gly Trp Leu Asp Thr Phe Leu 
        115                 120                 125             

Ala Leu Ile Ile Pro Arg Ala Ser Asn Ala Phe Gly Ile Phe Leu Leu 
    130                 135                 140                 

Arg Gln Phe Phe Ile Thr Ile Pro Gly Glu Leu Glu Asp Ala Ala Arg 
145                 150                 155                 160 

Ile Asp Gly Cys Ser Glu Phe Arg Ile Tyr Trp Asn Ile Ile Leu Pro 
                165                 170                 175     

Leu Ser Lys Pro Ala Leu Thr Thr Leu Ala Ile Phe His Phe Met Tyr 
            180                 185                 190         

Asn Trp Asn Asp Phe Leu Trp Pro Leu Val Met Thr Ser Ser Ser Thr 
        195                 200                 205             

Met Arg Thr Leu Pro Val Gly Leu Ala Leu Phe Met Gly Glu His Val 
    210                 215                 220                 

Ile Glu Tyr Gly Leu Leu Met Ala Gly Ala Thr Leu Ala Leu Leu Pro 
225                 230                 235                 240 

Ile Val Val Ala Tyr Leu Phe Ala Gln Arg Phe Phe Ile Lys Gly Ile 
                245                 250                 255     

Ala Leu Thr Gly Leu Lys 
            260         

<210>   396
<211>   258
<212>   PRT
<213>   Sinorhizobium medicae WSM419

<400>   396
Val Ala Ala Ile Leu Ala Leu Met Thr Val Phe Pro Leu Leu Trp Met 
                5                   10                  15      

Val Ser Ile Ala Phe Lys Gly Ala Gln Glu Ser Phe Ser Pro Ala Leu 
            20                  25                  30          

Leu Pro Ser Ala Pro Thr Trp Ser Asn Phe Val Tyr Val Leu Thr Glu 
        35                  40                  45              

Val Pro Phe Ile Arg Tyr Met Leu Asn Ser Leu Phe Val Ser Val Thr 
    50                  55                  60                  

Val Thr Val Val Ala Leu Phe Phe His Ser Met Ala Gly Tyr Ala Leu 
65                  70                  75                  80  

Ala Arg Leu Arg Phe Pro Gly Arg Glu Leu Ile Phe Leu Ala Ile Phe 
                85                  90                  95      

Ser Thr Leu Leu Val Ser Leu Pro Val Val Ile Val Pro Leu Phe Ile 
            100                 105                 110         

Ile Val Arg Ala Met Gly Met Leu Asn Thr Tyr Gly Gly Ile Ile Ile 
        115                 120                 125             

Pro Ser Ile Phe Asn Ala Phe Gly Ile Phe Leu Leu Arg Gln Tyr Tyr 
    130                 135                 140                 

Leu Ser Leu Pro Arg Glu Ile Glu Glu Ala Ala Val Met Asp Gly Ala 
145                 150                 155                 160 

Gly Tyr Trp Arg Ile Tyr Trp Ser Val Ile Leu Pro Leu Ser Lys Pro 
                165                 170                 175     

Ile Leu Ser Ala Leu Ala Ile Leu Phe Phe Leu Ala Asn Trp Asn Ala 
            180                 185                 190         

Phe Leu Trp Pro Leu Thr Val Ala Ser Asp Gln Lys Phe Trp Val Val 
        195                 200                 205             

Gln Val Gly Ile Ala Asn Phe Lys Ser Glu Tyr Ser Ala Ala Trp Asn 
    210                 215                 220                 

Tyr Met Leu Ala Ala Ser Thr Ile Val Ala Ile Pro Thr Leu Val Leu 
225                 230                 235                 240 

Phe Leu Val Phe Gln Arg Gln Ile Met Asp Ser Ile Lys Thr Ser Gly 
                245                 250                 255     

Leu Lys 
        

<210>   397
<211>   258
<212>   PRT
<213>   Sinorhizobium meliloti 1021

<400>   397
Val Thr Ala Ile Leu Ala Phe Met Thr Leu Phe Pro Leu Leu Trp Ile 
                5                   10                  15      

Val Ser Ile Ala Phe Lys Pro Ala Ala Glu Ser Phe Ser Ser Asn Leu 
            20                  25                  30          

Ile Pro Gln Ala Pro Thr Leu Asp Asn Phe Ile Tyr Val Leu Thr Gly 
        35                  40                  45              

Val Pro Phe Ile Arg Tyr Met Val Asn Ser Phe Leu Val Ser Ala Thr 
    50                  55                  60                  

Val Thr Val Val Ala Leu Phe Phe His Thr Met Ala Gly Tyr Ala Leu 
65                  70                  75                  80  

Ala Arg Leu Arg Phe Pro Gly Arg Glu Val Met Phe Leu Ser Ile Phe 
                85                  90                  95      

Ser Thr Phe Leu Val Ser Leu Pro Val Ile Ile Val Pro Leu Phe Val 
            100                 105                 110         

Ile Val Lys Ala Met Gly Met Leu Asn Ser Tyr Ala Gly Leu Ile Ile 
        115                 120                 125             

Pro Ala Ile Phe Asn Ala Phe Gly Ile Phe Leu Leu Arg Gln Tyr Tyr 
    130                 135                 140                 

Leu Ser Leu Pro Lys Glu Ile Glu Glu Ala Ala Arg Ile Asp Gly Ala 
145                 150                 155                 160 

Gly Tyr Trp Arg Ile Tyr Trp Ser Val Ile Leu Pro Leu Ser Arg Pro 
                165                 170                 175     

Ile Met Ser Ala Leu Ala Ile Leu Phe Phe Leu Ala Asn Trp Asn Ser 
            180                 185                 190         

Phe Leu Trp Pro Leu Thr Ile Thr Ser Asp Pro Asp Leu Trp Val Val 
        195                 200                 205             

Gln Leu Gly Ile Ala Asn Phe Lys Ser Gln Tyr Ser Ala Ser Trp Asn 
    210                 215                 220                 

Tyr Met Met Ala Ala Ser Thr Ile Val Ala Ile Pro Thr Leu Ile Leu 
225                 230                 235                 240 

Phe Val Ile Phe Gln Arg Gln Ile Met Asp Ser Leu Lys Thr Ser Gly 
                245                 250                 255     

Leu Lys 
        

<210>   398
<211>   265
<212>   PRT
<213>   Listeria monocytogenes EGD-e

<400>   398
Ile Leu Thr Tyr Thr Ile Ile Cys Leu Gly Gly Ile Ile Met Leu Met 
                5                   10                  15      

Pro Phe Val Trp Met Val Ser Thr Ala Phe Lys Thr Gly Ala Ala Asn 
            20                  25                  30          

Met Val Leu Pro Pro Gln Phe Ile Pro Lys Glu Pro Thr Thr Ala Asn 
        35                  40                  45              

Phe Thr Gln Val Phe Glu Met Phe Pro Met Leu Arg Phe Leu Val Asn 
    50                  55                  60                  

Ser Val Ile Val Ala Val Val Thr Thr Leu Gly Gln Met Leu Phe Cys 
65                  70                  75                  80  

Ser Met Ala Ala Tyr Ala Phe Ala Arg Ile Pro Phe Trp Gly Arg Asp 
                85                  90                  95      

Lys Leu Phe Leu Leu Tyr Leu Ala Thr Met Met Val Pro Ala Gln Val 
            100                 105                 110         

Thr Met Ile Pro Gln Phe Ile Leu Met Lys Gln Phe Gly Trp Leu Asp 
        115                 120                 125             

Ser Tyr Ala Gly Leu Ile Val Pro Ala Leu Phe Ser Val Phe Gly Thr 
    130                 135                 140                 

Phe Leu Leu Arg Gln Ala Phe Met Gly Ile Pro Lys Glu Leu Glu Glu 
145                 150                 155                 160 

Ala Ala Phe Met Asp Gly Ala Asn His Phe Thr Ile Phe Arg Lys Val 
                165                 170                 175     

Ile Leu Pro Leu Ala Lys Pro Thr Phe Ala Thr Leu Gly Ile Leu Thr 
            180                 185                 190         

Phe Met Gln Ser Trp Asn Ser Tyr Leu Trp Pro Leu Ile Val Thr Ser 
        195                 200                 205             

Ser Gln Glu Met Ala Thr Leu Pro Leu Gly Leu Ser Leu Leu Gln Gly 
    210                 215                 220                 

Arg Tyr Gly Thr Asn Tyr Gly Leu Met Met Ala Gly Val Leu Ile Ser 
225                 230                 235                 240 

Val Ile Pro Ile Leu Ala Val Tyr Leu Phe Ala Gln Lys Tyr Phe Ile 
                245                 250                 255     

Gln Gly Met Ala Met Ser Gly Met Lys 
            260                 265 

<210>   399
<211>   289
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   399
Met Arg Gly Leu Trp Gln Ser Gly Arg Arg Arg Glu Gly Leu Arg Leu 
                5                   10                  15      

Met Arg Arg Ile Leu Thr Ile Leu Ala Ala Tyr Phe Val Leu Ala Val 
            20                  25                  30          

Gly Ala Phe Ile Ser Ile Phe Pro Tyr Leu Trp Ala Val Leu Thr Ser 
        35                  40                  45              

Leu Lys Pro Glu Ser Glu Val Phe Thr Ser His Phe Leu Ser Leu Pro 
    50                  55                  60                  

Thr His Ile Glu Trp Ala Asn Tyr Thr His Val Phe Gln Gln Ile Asn 
65                  70                  75                  80  

Met Gly Arg Tyr Leu Leu Asn Thr Val Ile Val Ala Val Ala Ser Val 
                85                  90                  95      

Leu Gly Gln Leu Ile Phe Gly Ser Met Ala Ala Tyr Gly Phe Ser Arg 
            100                 105                 110         

Phe Asn Phe Lys Gly Lys Asn Val Ile Phe Met Leu Tyr Leu Ser Thr 
        115                 120                 125             

Leu Met Ile Pro Asn Ile Val Thr Leu Ile Pro Leu Phe Ile Met Met 
    130                 135                 140                 

Lys Tyr Leu Gly Trp Ile Asn Thr Tyr Tyr Ala Leu Ile Ala Pro Ala 
145                 150                 155                 160 

Ala Leu Gly Thr Pro Val Gly Ile Phe Leu Leu Arg Gln Phe Phe Leu 
                165                 170                 175     

Thr Ile Pro Ser Glu Ile Glu Glu Ala Ala Arg Met Asp Gly Ala Gly 
            180                 185                 190         

Val Ile Arg Val Phe Val Gln Ile Ile Leu Pro Leu Ser Lys Pro Val 
        195                 200                 205             

Leu Ala Thr Leu Ala Ile Ile Thr Phe Val Ser Ser Trp Asn Asn Phe 
    210                 215                 220                 

Leu Trp Pro Leu Ile Val Thr Asn Thr Asp Ser Met Lys Leu Val Ser 
225                 230                 235                 240 

Ile Gly Ile Ala Ser Phe Gln Phe Gln Val Gly Ala Glu Trp Asn Tyr 
                245                 250                 255     

Met Met Ala Ala Ser Thr Ile Ala Leu Leu Pro Leu Val Ile Leu Phe 
            260                 265                 270         

Leu Leu Phe Gln Arg Arg Ile Ile Glu Ser Ile Gln Leu Thr Gly Leu 
        275                 280                 285             

Lys 
    

<210>   400
<211>   289
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   400
Met Arg Gly Leu Trp Gln Ser Gly Arg Arg Arg Glu Gly Leu Arg Leu 
                5                   10                  15      

Met Arg Arg Ile Leu Thr Ile Leu Ala Ala Tyr Phe Val Leu Ala Val 
            20                  25                  30          

Gly Ala Phe Ile Ser Ile Phe Pro Tyr Leu Trp Ala Val Leu Thr Ser 
        35                  40                  45              

Leu Lys Pro Glu Ser Glu Val Phe Thr Ser His Phe Leu Ser Leu Pro 
    50                  55                  60                  

Thr His Ile Glu Trp Ala Asn Tyr Thr His Val Phe Gln Gln Ile Asn 
65                  70                  75                  80  

Met Gly Arg Tyr Leu Leu Asn Thr Val Ile Val Ala Val Ala Ser Val 
                85                  90                  95      

Leu Gly Gln Leu Ile Phe Gly Ser Met Ala Ala Tyr Gly Phe Ser Arg 
            100                 105                 110         

Phe Asn Phe Lys Gly Lys Asn Val Ile Phe Met Leu Tyr Leu Ser Thr 
        115                 120                 125             

Leu Met Ile Pro Asn Ile Val Thr Leu Leu Pro Leu Phe Ile Met Met 
    130                 135                 140                 

Lys Tyr Leu Gly Trp Ile Asn Thr Tyr Tyr Ala Leu Ile Ala Pro Ala 
145                 150                 155                 160 

Ala Leu Gly Thr Pro Val Gly Ile Phe Leu Leu Arg Gln Phe Phe Leu 
                165                 170                 175     

Thr Ile Pro Ser Glu Ile Glu Glu Ala Ala Arg Met Asp Gly Ala Gly 
            180                 185                 190         

Val Ile Arg Val Phe Val Gln Ile Ile Leu Pro Leu Ser Lys Pro Val 
        195                 200                 205             

Leu Ala Thr Leu Ala Ile Ile Thr Phe Val Ser Ser Trp Asn Asn Phe 
    210                 215                 220                 

Leu Trp Pro Leu Ile Val Thr Asn Thr Asp Ser Met Lys Leu Val Ser 
225                 230                 235                 240 

Val Gly Ile Ala Ser Phe Gln Phe Gln Val Gly Ala Glu Trp Asn Tyr 
                245                 250                 255     

Met Met Ala Ala Ser Thr Ile Ala Leu Leu Pro Leu Val Ile Leu Phe 
            260                 265                 270         

Leu Leu Phe Gln Arg Arg Ile Ile Glu Ser Ile Gln Leu Thr Gly Leu 
        275                 280                 285             

Lys 
    

<210>   401
<211>   289
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   401
Met Arg Gly Leu Trp Gln Ser Gly Arg Arg Arg Glu Gly Leu Arg Leu 
                5                   10                  15      

Met Arg Arg Ile Leu Thr Ile Leu Ala Ala Tyr Phe Val Leu Ala Val 
            20                  25                  30          

Gly Ala Phe Ile Ser Ile Phe Pro Tyr Leu Trp Ala Val Leu Thr Ser 
        35                  40                  45              

Leu Lys Pro Glu Ser Glu Val Phe Thr Ser His Phe Leu Ser Leu Pro 
    50                  55                  60                  

Thr His Ile Glu Trp Ala Asn Tyr Thr His Val Phe Gln Gln Ile Asn 
65                  70                  75                  80  

Met Gly Arg Tyr Leu Leu Asn Thr Val Ile Val Ala Val Ala Ser Val 
                85                  90                  95      

Leu Gly Gln Leu Ile Phe Gly Ser Met Ala Ala Tyr Gly Phe Ser Arg 
            100                 105                 110         

Phe Asn Phe Lys Gly Lys Asn Val Ile Phe Met Leu Tyr Leu Ser Thr 
        115                 120                 125             

Leu Met Ile Pro Asn Ile Val Thr Leu Ile Pro Leu Phe Ile Met Met 
    130                 135                 140                 

Lys Tyr Leu Gly Trp Ile Asn Thr Tyr Tyr Ala Leu Ile Ala Pro Ala 
145                 150                 155                 160 

Ala Leu Gly Thr Pro Val Gly Ile Phe Leu Leu Arg Gln Phe Phe Leu 
                165                 170                 175     

Thr Ile Pro Ser Glu Ile Glu Glu Ala Ala Arg Met Asp Gly Ala Gly 
            180                 185                 190         

Val Ile Arg Val Phe Val Gln Ile Ile Leu Pro Leu Ser Lys Pro Val 
        195                 200                 205             

Leu Ala Thr Leu Ala Ile Ile Thr Phe Val Ser Ser Trp Asn Asn Phe 
    210                 215                 220                 

Leu Trp Pro Leu Ile Ile Thr Asn Thr Asp Ser Met Lys Leu Val Ser 
225                 230                 235                 240 

Val Gly Ile Ala Ser Phe Gln Phe Gln Val Gly Ala Glu Trp Asn Tyr 
                245                 250                 255     

Met Met Ala Ala Ser Thr Ile Ala Leu Leu Pro Leu Val Ile Leu Phe 
            260                 265                 270         

Leu Leu Phe Gln Arg Arg Ile Ile Glu Ser Ile Gln Leu Thr Gly Leu 
        275                 280                 285             

Lys 
    

<210>   402
<211>   289
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   402
Met Arg Gly Leu Trp Gln Ser Gly Arg Arg Arg Glu Gly Leu Arg Leu 
                5                   10                  15      

Met Arg Arg Ile Leu Thr Ile Leu Ala Ala Tyr Phe Val Leu Ala Val 
            20                  25                  30          

Gly Ala Phe Ile Ser Ile Phe Pro Tyr Leu Trp Ala Val Leu Thr Ser 
        35                  40                  45              

Leu Lys Pro Glu Ser Glu Val Phe Thr Ser His Phe Leu Ser Leu Pro 
    50                  55                  60                  

Thr His Ile Glu Trp Ala Asn Tyr Thr His Val Phe Gln Gln Ile Asn 
65                  70                  75                  80  

Met Gly Arg Tyr Leu Leu Asn Thr Val Ile Val Ala Val Ala Ser Val 
                85                  90                  95      

Leu Gly Gln Leu Ile Phe Gly Ser Met Ala Ala Tyr Gly Phe Ser Arg 
            100                 105                 110         

Phe Asn Phe Lys Gly Arg Asn Val Ile Phe Met Leu Tyr Leu Ser Thr 
        115                 120                 125             

Leu Met Ile Pro Asn Ile Val Thr Leu Ile Pro Leu Phe Ile Met Met 
    130                 135                 140                 

Lys Tyr Leu Gly Trp Ile Asn Thr Tyr Tyr Ala Leu Ile Ala Pro Ala 
145                 150                 155                 160 

Ala Leu Gly Thr Pro Val Gly Ile Phe Leu Leu Arg Gln Phe Phe Leu 
                165                 170                 175     

Thr Ile Pro Ser Glu Ile Glu Glu Ala Ala Arg Met Asp Gly Ala Gly 
            180                 185                 190         

Val Ile Arg Val Phe Val Gln Ile Ile Leu Pro Leu Ser Lys Pro Val 
        195                 200                 205             

Leu Ala Thr Leu Ala Ile Ile Thr Phe Val Ser Ser Trp Asn Asn Phe 
    210                 215                 220                 

Leu Trp Pro Leu Ile Val Thr Asn Thr Asp Ser Met Lys Leu Val Ser 
225                 230                 235                 240 

Val Gly Ile Ala Ser Phe Gln Phe Gln Val Gly Ala Glu Trp Asn Tyr 
                245                 250                 255     

Met Met Ala Ala Ser Thr Ile Ala Leu Leu Pro Leu Val Ile Leu Phe 
            260                 265                 270         

Leu Leu Phe Gln Arg Arg Ile Ile Glu Ser Ile Gln Leu Thr Gly Leu 
        275                 280                 285             

Lys 
    

<210>   403
<211>   289
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 392

<400>   403
Met Arg Gly Leu Trp Gln Ser Gly Arg Arg Arg Glu Gly Leu Arg Leu 
                5                   10                  15      

Met Arg Arg Ile Leu Thr Ile Leu Ala Ala Tyr Phe Val Leu Ala Val 
            20                  25                  30          

Gly Ala Phe Ile Ser Ile Phe Pro Tyr Leu Trp Ala Val Leu Thr Ser 
        35                  40                  45              

Leu Lys Pro Glu Ser Glu Val Phe Thr Ser His Phe Leu Ser Leu Pro 
    50                  55                  60                  

Thr His Ile Glu Trp Ala Asn Tyr Thr His Val Phe Gln Gln Ile Asn 
65                  70                  75                  80  

Met Gly Arg Tyr Leu Leu Asn Thr Val Ile Val Ala Val Ala Ser Val 
                85                  90                  95      

Ile Gly Gln Leu Ile Phe Gly Ser Met Ala Ala Tyr Gly Phe Ser Arg 
            100                 105                 110         

Phe Asn Phe Lys Gly Lys Asn Val Ile Phe Met Leu Tyr Leu Ser Thr 
        115                 120                 125             

Leu Met Ile Pro Asn Ile Val Thr Leu Ile Pro Leu Phe Ile Met Met 
    130                 135                 140                 

Lys Tyr Leu Gly Trp Ile Asn Thr Tyr Tyr Ala Leu Ile Ala Pro Ala 
145                 150                 155                 160 

Ala Leu Gly Thr Pro Val Gly Ile Phe Leu Leu Arg Gln Phe Phe Leu 
                165                 170                 175     

Thr Ile Pro Ser Glu Ile Glu Glu Ala Ala Arg Met Asp Gly Ala Gly 
            180                 185                 190         

Val Ile Arg Val Phe Val Gln Ile Ile Leu Pro Leu Ser Lys Pro Val 
        195                 200                 205             

Leu Ala Thr Leu Ala Ile Ile Thr Phe Val Ser Ser Trp Asn Asn Phe 
    210                 215                 220                 

Leu Trp Pro Leu Ile Val Thr Asn Thr Asp Ser Met Lys Leu Val Ser 
225                 230                 235                 240 

Val Gly Ile Ala Ser Phe Gln Phe Gln Val Gly Ala Glu Trp Asn Tyr 
                245                 250                 255     

Met Met Ala Ala Ser Thr Ile Ala Leu Leu Pro Leu Val Ile Leu Phe 
            260                 265                 270         

Leu Leu Phe Gln Arg Arg Ile Ile Glu Ser Ile Gln Leu Thr Gly Leu 
        275                 280                 285             

Lys 
    

<210>   404
<211>   870
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   404
ttgcggggct tgtggcagtc tggccgccgg agggagggac ttcggcttat gaggcgaatt       60

cttacgattc ttgctgctta cttcgtcctc gctgtaggtg cattcatatc catatttccg      120

tatctgtggg ccgtacttac ttctttgaag cctgaaagcg aggtcttcac atctcacttt      180

ttgagtctgc cgactcacat cgaatgggcc aactataccc atgtatttca acagattaac      240

atggggcgat acttactgaa caccgtgatt gtggcagttg cgagcgtgct aggccagctc      300

attttcggtt ctatggctgc ctatggattt tcgcggttta actttaaggg gaagaatgta      360

atattcatgc tttatttaag tacgctcatg atccccaaca tcgtaacact cattcctcta      420

tttatcatga tgaaatatct ggggtggatc aacacctact atgcactcat tgcgccagct      480

gcgctcggga ctccggtggg catatttctg ttgagacaat ttttcctaac tattccctct      540

gagattgaag aagccgctcg aatggacgga gcaggtgtca ttcgagtatt cgtacaaatc      600

atcttgcctt taagcaaacc ggttctagcg actttggcaa tcattacgtt cgtgtcgtca      660

tggaacaact ttctatggcc cctcattgtg acgaataccg actctatgaa gcttgtgagt      720

attggcattg cctcgtttca atttcaagta ggtgcagaat ggaactacat gatggctgct      780

tccacaatag ccctgctccc attggtcatc ctattcttgc tgtttcagcg caggattatc      840

gagtcaattc agctcactgg gttgaagtag                                       870


<210>   405
<211>   870
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   405
ttgcggggct tgtggcagtc tggccgccgg agggagggac ttcggcttat gaggcgaatt       60

cttacgattc ttgctgctta cttcgtcctc gctgtaggtg cattcatatc catatttccg      120

tatctgtggg ccgtacttac ttctttgaag cctgaaagcg aggtcttcac atctcacttt      180

ttgagtctgc cgactcacat cgaatgggcc aactataccc atgtatttca acagattaac      240

atggggcgat acttactgaa caccgtgatt gtggcagttg cgagcgtgct aggccagctc      300

attttcggtt ctatggctgc ctatggattt tcgcggttta actttaaggg gaagaatgta      360

atattcatgc tttatttaag tacgctcatg atccccaaca tcgtaacact cttacctcta      420

tttatcatga tgaaatatct ggggtggatc aacacctact atgcactcat tgcgccagct      480

gcgctcggga ctccggtggg catatttctg ttgagacaat ttttcctaac tattccctct      540

gagattgaag aagccgctcg aatggacgga gcaggtgtca ttcgagtatt cgtacaaatc      600

atcttgcctt taagcaaacc ggttctagcg actttggcaa tcattacgtt cgtgtcgtca      660

tggaacaact ttctatggcc cctcattgtg acgaataccg actctatgaa gcttgtgagt      720

gtaggcattg cctcgtttca atttcaagta ggtgcagaat ggaactacat gatggctgct      780

tccacaatag ccctgctccc attggtcatc ctattcttgc tgtttcagcg caggattatc      840

gagtcaattc agctcactgg gttgaagtag                                       870


<210>   406
<211>   870
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   406
ttgcggggct tgtggcagtc tggccgccgg agggagggac ttcggcttat gaggcgaatt       60

cttacgattc ttgctgctta cttcgtcctc gctgtaggtg cattcatatc catatttccg      120

tatctgtggg ccgtacttac ttctttgaag cctgaaagcg aggtcttcac atctcacttt      180

ttgagtctgc cgactcacat cgaatgggcc aactataccc atgtatttca acagattaac      240

atggggcgat acttactgaa caccgtgatt gtggcagttg cgagcgtgct aggccagctc      300

attttcggtt ctatggctgc ctatggattt tcgcggttta actttaaggg gaagaatgta      360

atattcatgc tttatttaag tacgctcatg atccccaaca tcgtaacact cattcctcta      420

tttatcatga tgaaatatct ggggtggatc aacacctact atgcactcat tgcgccagct      480

gcgctcggga ctccggtggg catatttctg ttgagacaat ttttcctaac tattccctct      540

gagattgaag aagccgctcg aatggacgga gcaggtgtca ttcgagtatt cgtacaaatc      600

atcttgcctt taagcaaacc ggttctagcg actttggcaa tcattacgtt cgtgtcgtca      660

tggaacaact ttctatggcc cctcattatt acgaataccg actctatgaa gcttgtgagt      720

gtaggcattg cctcgtttca atttcaagta ggtgcagaat ggaactacat gatggctgct      780

tccacaatag ccctgctccc attggtcatc ctattcttgc tgtttcagcg caggattatc      840

gagtcaattc agctcactgg gttgaagtag                                       870


<210>   407
<211>   870
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   407
ttgcggggct tgtggcagtc tggccgccgg agggagggac ttcggcttat gaggcgaatt       60

cttacgattc ttgctgctta cttcgtcctc gctgtaggtg cattcatatc catatttccg      120

tatctgtggg ccgtacttac ttctttgaag cctgaaagcg aggtcttcac atctcacttt      180

ttgagtctgc cgactcacat cgaatgggcc aactataccc atgtatttca acagattaac      240

atggggcgat acttactgaa caccgtgatt gtggcagttg cgagcgtgct aggccagctc      300

attttcggtt ctatggctgc ctatggattt tcgcggttta actttaaggg gcgtaatgta      360

atattcatgc tttatttaag tacgctcatg atccccaaca tcgtaacact cattcctcta      420

tttatcatga tgaaatatct ggggtggatc aacacctact atgcactcat tgcgccagct      480

gcgctcggga ctccggtggg catatttctg ttgagacaat ttttcctaac tattccctct      540

gagattgaag aagccgctcg aatggacgga gcaggtgtca ttcgagtatt cgtacaaatc      600

atcttgcctt taagcaaacc ggttctagcg actttggcaa tcattacgtt cgtgtcgtca      660

tggaacaact ttctatggcc cctcattgtg acgaataccg actctatgaa gcttgtgagt      720

gtaggcattg cctcgtttca atttcaagta ggtgcagaat ggaactacat gatggctgct      780

tccacaatag ccctgctccc attggtcatc ctattcttgc tgtttcagcg caggattatc      840

gagtcaattc agctcactgg gttgaagtag                                       870


<210>   408
<211>   870
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 393

<400>   408
ttgcggggct tgtggcagtc tggccgccgg agggagggac ttcggcttat gaggcgaatt       60

cttacgattc ttgctgctta cttcgtcctc gctgtaggtg cattcatatc catatttccg      120

tatctgtggg ccgtacttac ttctttgaag cctgaaagcg aggtcttcac atctcacttt      180

ttgagtctgc cgactcacat cgaatgggcc aactataccc atgtatttca acagattaac      240

atggggcgat acttactgaa caccgtgatt gtggcagttg cgagcgtgat tggccagctc      300

attttcggtt ctatggctgc ctatggattt tcgcggttta actttaaggg gaagaatgta      360

atattcatgc tttatttaag tacgctcatg atccccaaca tcgtaacact cattcctcta      420

tttatcatga tgaaatatct ggggtggatc aacacctact atgcactcat tgcgccagct      480

gcgctcggga ctccggtggg catatttctg ttgagacaat ttttcctaac tattccctct      540

gagattgaag aagccgctcg aatggacgga gcaggtgtca ttcgagtatt cgtacaaatc      600

atcttgcctt taagcaaacc ggttctagcg actttggcaa tcattacgtt cgtgtcgtca      660

tggaacaact ttctatggcc cctcattgtg acgaataccg actctatgaa gcttgtgagt      720

gtaggcattg cctcgtttca atttcaagta ggtgcagaat ggaactacat gatggctgct      780

tccacaatag ccctgctccc attggtcatc ctattcttgc tgtttcagcg caggattatc      840

gagtcaattc agctcactgg gttgaagtag                                       870


<210>   409
<211>   460
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   409
Met Asn Arg Asn Gly Lys Lys Val Val Phe Thr Ile Pro Val Val Leu 
                5                   10                  15      

Thr Met Leu Leu Val Gly Cys Gly Thr Ser Thr Ala Asn Lys Pro Gly 
            20                  25                  30          

His Gln Phe Ser Thr Ser Glu Gly Ser Ala Ser Thr Gln Val Val Thr 
        35                  40                  45              

Leu His Tyr Met Leu Trp Asp Pro Asn Glu Glu Ile Gly Tyr Lys Gln 
    50                  55                  60                  

Ser Ile Ala Val Phe Glu Lys Leu His Pro Asn Ile Lys Val Val Ile 
65                  70                  75                  80  

Glu Gln Tyr Pro Trp Ser Gln Tyr Trp Gln Lys Leu Glu Thr Glu Met 
                85                  90                  95      

Ala Ala Gly Thr Ala Pro Asp Val Phe Trp Asp His Val Thr Tyr Phe 
            100                 105                 110         

Pro Thr Phe Val Thr Asn Gly Gln Leu Leu Asn Leu Thr Pro Tyr Ile 
        115                 120                 125             

Lys Ser Ser His Val Asp Leu Arg Glu Tyr Tyr Pro Asn Leu Leu Lys 
    130                 135                 140                 

Gln Tyr Glu Tyr Asn Gly Asn Ile Tyr Gly Leu Pro Lys Asp Trp Asp 
145                 150                 155                 160 

Thr Ile Ala Ile Phe Tyr Asn Lys Lys Leu Phe Glu Lys Asp His Val 
                165                 170                 175     

Pro Phe Pro Thr Asn Leu Thr Trp Asn Pro Arg Asn Gly Gly Thr Leu 
            180                 185                 190         

Val Lys Val Ala Glu Glu Met Thr Val Asp Lys Asn Gly Lys His Pro 
        195                 200                 205             

Gly Gln Pro Gly Phe Asn Pro Asn Gln Ile Val Gln Tyr Gly Phe Met 
    210                 215                 220                 

Ser Tyr Asn Ser Asn Gln Ser Phe Tyr Tyr Asn Phe Leu Ala Glu Asp 
225                 230                 235                 240 

Gly Val Lys Ile Leu Asp His Asn Phe Gly Thr Gln Val Leu Met Asp 
                245                 250                 255     

Thr Pro Gln Ala Ile Gln Thr Met Gln Asn Leu Ile Asp Met Ile Tyr 
            260                 265                 270         

Lys Tyr His Val Ser Pro Ser Gly Ala Glu Gly Ala Asn Val Val Asn 
        275                 280                 285             

Ser Glu Gly Asn Ala Gln Gln Leu Phe Glu Glu Gly Lys Leu Ala Met 
    290                 295                 300                 

Tyr Thr Asp Gly Asp Trp Val Leu Thr Pro Val Val Lys Ala Ser Asn 
305                 310                 315                 320 

Phe Pro Val Gly Ile Ala Pro Leu Pro Val Gly Pro Ile Gly Arg Val 
                325                 330                 335     

Ser Val Met Asn Gly Leu Ser Asp Ala Ile Tyr Ala His Thr Lys Tyr 
            340                 345                 350         

Pro Lys Gln Ala Trp Glu Leu Val Gln Trp Leu Ala Ser Pro Gln Ser 
        355                 360                 365             

Glu Arg Ile Leu Ala Ser Gly Gly Tyr Val Trp Pro Gly Ile Lys Ser 
    370                 375                 380                 

Leu Ala Pro Leu Phe Ala Gln Ala Trp Thr Lys Lys Gly Val Asp Val 
385                 390                 395                 400 

Thr Pro Phe Leu Glu Glu Ser Arg Gly Lys Thr Ile Ser Phe Pro Ile 
                405                 410                 415     

Thr Val Asn Trp Gly Gln Ala Glu Asn Ala Ile Asp Lys Glu Phe Asp 
            420                 425                 430         

Leu Met Trp Leu Gly Lys Val Pro Pro Ser Gln Ala Leu Gln Thr Ala 
        435                 440                 445             

Val Gln Gln Ala Asp Ala Ala Leu Asn Gly Gly Gln 
    450                 455                 460 

<210>   410
<211>   1383
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   410
atgaatcgta atggaaagaa ggttgttttt actattccgg ttgttctgac gatgctccta       60

gttggatgtg gtacatcaac tgcgaataag cctggtcatc agttctcaac gagtgaaggc      120

agtgcttcta cccaagttgt cacgttacat tacatgctct gggatccgaa cgaggaaatc      180

ggttacaagc agtccatcgc cgtctttgaa aagttacatc cgaatatcaa agttgtcatc      240

gaacagtacc cgtggtctca gtattggcaa aaattagaga ctgaaatggc ggcagggaca      300

gctcccgacg tgttttggga tcatgttact tatttcccta cttttgttac gaacggtcaa      360

cttctcaatt tgacgcctta tattaagagt tcccatgtcg atttgagaga atattatccg      420

aacttgctga agcagtacga gtacaacgga aatatttatg gcctgccaaa ggactgggac      480

acgatagcca tattttataa caagaagctg ttcgaaaagg atcatgttcc atttccaaca      540

aacttgactt ggaatcctag aaatggtgga acattggtca aggttgctga agaaatgacc      600

gtagataaga acggaaaaca cccgggccag ccagggttca atccgaacca aatcgtacaa      660

tacggattta tgtcatataa ctcaaatcag tcattttatt acaacttttt ggccgaagac      720

ggagtgaaaa tcctagacca taacttcggg actcaggtgc taatggacac cccgcaggcc      780

attcagacca tgcagaatct tattgacatg atttacaagt accatgtatc gccttctgga      840

gccgagggag ctaacgttgt aaatagtgaa ggaaatgctc agcaattatt tgaagaaggt      900

aagctggcga tgtacaccga tggcgattgg gtcctgacac ctgtcgtgaa ggcaagcaat      960

ttccctgtcg ggatagctcc gctacctgtc gggccaatag gtcgtgtgtc tgtcatgaac     1020

ggactgtcgg acgccatcta tgcgcatacg aagtacccaa agcaagcgtg ggaactggtt     1080

cagtggctgg cgagtccgca atctgagcgg atcctcgcat cgggtggtta cgtatggcct     1140

gggatcaagt cgttggcacc actgtttgca caggcctgga ccaagaaagg cgtcgatgtc     1200

acgccgttcc tcgaagaatc gaggggtaag accatatcgt tccccatcac tgtgaactgg     1260

gggcaagctg agaacgcgat cgacaaagaa ttcgatttaa tgtggctagg gaaagtgccc     1320

ccgtctcagg cgctccaaac agccgtgcag caggcggatg cggcactgaa tggcggtcag     1380

tga                                                                   1383


<210>   411
<211>   424
<212>   PRT
<213>   Renibacterium salmoninarum ATCC 33209

<400>   411
Thr Ala Thr Ala Cys Ser Pro Ala Ala Asp Asn Gly Gly Thr Ala Ser 
                5                   10                  15      

Gly Asp Lys Val Thr Val Ser Val Arg Leu Trp Asp Glu Gln Val Gln 
            20                  25                  30          

Lys Ala Tyr Glu Ser Ser Phe Lys Glu Phe Glu Ser Gln Asn Pro Gly 
        35                  40                  45              

Ile Gln Val Lys Thr Val Leu Glu Pro Tyr Thr Thr Tyr Phe Asn Lys 
    50                  55                  60                  

Leu Arg Thr Asp Val Ser Ala Gly Asn Ala Asp Asp Val Phe Trp Ile 
65                  70                  75                  80  

Ser Ser Ser Tyr Phe Ser Pro Tyr Ala Asp Asn Gly Ser Leu Leu Pro 
                85                  90                  95      

Ile Gly Ser Glu Phe Asp Ser Ala Lys Ser Gly Trp Val Pro Ala Ala 
            100                 105                 110         

Val Ser Gln Tyr Thr Arg Asn Asp Lys Leu Trp Gly Val Pro Gln Leu 
        115                 120                 125             

Thr Asp Gly Gly Ile Gly Val Tyr Tyr Asn Lys Asp Leu Val Ala Lys 
    130                 135                 140                 

Ala Gly Val Ser Leu Asp Asn Leu Ser Trp Asn Pro Thr Asp Pro Ala 
145                 150                 155                 160 

Gln Asp Thr Phe Leu Lys Ala Ala Gln Lys Leu Thr Leu Asp Ser Ala 
                165                 170                 175     

Gly Arg Thr Ala Asp Asp Pro Ala Phe Asp Ala Asn Asn Ile Val Gln 
            180                 185                 190         

Tyr Gly Tyr Asn Ala Ser Gln Asp Leu Gln Ala Ile Tyr Tyr Asn Phe 
        195                 200                 205             

Ile Gly Gln Asn Gly Gly Ala Phe Gln Asp Gly Glu Lys Phe Val Phe 
    210                 215                 220                 

Ala Ser Pro Gln Ser Ala Gln Ala Phe Gln Tyr Ile Val Asp Leu Ile 
225                 230                 235                 240 

Asn Lys Tyr His Val Ser Pro Gly Ala Ala Asn Ser Asn Asp Asn Gly 
                245                 250                 255     

Asp Phe Met Arg Asp Gln Phe Ile Gln Gly Lys Ile Ser Met Phe Gln 
            260                 265                 270         

Ser Gly Thr Tyr Asn Leu Ala Asn Val Thr Gln Gly Ala Lys Tyr Pro 
        275                 280                 285             

Trp Ala Ile Ala Pro Met Pro Thr Gly Pro Ala Gly Ala Val Ser Val 
    290                 295                 300                 

Val Asn Asn Ile Ile Ala Ala Gly Asn Ala Lys Thr Ala His Lys Asp 
305                 310                 315                 320 

Ala Thr Thr Lys Val Leu Gln Trp Leu Gly Ser Thr Glu Gly Ala Lys 
                325                 330                 335     

Phe Ile Gly Ala Glu Gly Ala Ala Asp Pro Ala Val Thr Gly Ala Gln 
            340                 345                 350         

Asp Ala Tyr Ser Ser Tyr Trp Lys Ala Lys Asp Val Asp Val Ser Val 
        355                 360                 365             

Phe Ala Lys Ala Ala Glu Gly Lys Thr Ile Gln Ala Pro Val Gly Thr 
    370                 375                 380                 

Asn Tyr Gly Ala Ala Val Asn Ala Trp Lys Pro Ile Phe Ser Glu Ile 
385                 390                 395                 400 

Phe Leu Gly Arg Thr Pro Val Val Ser Gly Leu Gln Gln Ala Gln Asp 
                405                 410                 415     

Ala Ala Asn Lys Ala Ile Ala Gly 
            420                 

<210>   412
<211>   420
<212>   PRT
<213>   Arthrobacter sp. FB24

<400>   412
Ser Gly Ser Ser Ala Glu Ser Ala Lys Gly Glu Leu Ser Tyr Trp Leu 
                5                   10                  15      

Trp Asp Ala Asn Gln Leu Pro Ala Tyr Gln Gln Cys Ala Asp Asp Phe 
            20                  25                  30          

Gln Lys Ala Asn Pro Asp Ile Lys Val Lys Ile Thr Gln Arg Gly Trp 
        35                  40                  45              

Asp Asp Tyr Trp Ser Thr Leu Thr Asn Gly Phe Val Gly Gly Thr Ala 
    50                  55                  60                  

Pro Asp Val Phe Thr Asn His Leu Gly Arg Tyr Gly Glu Leu Ala Ala 
65                  70                  75                  80  

Asn Lys Gln Leu Leu Pro Ile Asp Asp Ala Val Lys Lys Asp Asn Val 
                85                  90                  95      

Asp Leu Ser Ala Tyr Asn Glu Gly Leu Ala Asp Leu Trp Val Gly Gln 
            100                 105                 110         

Asp Gly Lys Arg Tyr Gly Leu Pro Lys Asp Trp Asp Thr Ile Gly Leu 
        115                 120                 125             

Phe Tyr Asn Lys Ala Met Leu Ser Lys Ala Gly Val Ser Glu Glu Glu 
    130                 135                 140                 

Met Lys Asn Leu Thr Trp Asn Pro Gln Asp Gly Gly Thr Tyr Glu Lys 
145                 150                 155                 160 

Ile Ile Ala His Leu Thr Val Asp Lys Asn Gly Lys Arg Gly Asp Glu 
                165                 170                 175     

Ala Gly Phe Asp Lys Asn Asn Val Asp Val Tyr Gly Leu Gly Leu Asn 
            180                 185                 190         

Gly Gly Gly Asp Ser Ser Gly Gln Thr Glu Trp Ser Tyr Leu Thr Asn 
        195                 200                 205             

Thr Thr Gly Trp Ser His Thr Asp Lys Asn Pro Trp Gly Thr His Tyr 
    210                 215                 220                 

Asn Tyr Asp Asp Pro Lys Phe Gln Ser Ser Ile Asp Trp Phe Ala Gly 
225                 230                 235                 240 

Leu Val Asp Lys Gly Tyr Met Pro Lys Leu Glu Thr Thr Val Gly Ala 
                245                 250                 255     

Ala Met Ala Asp Thr Phe Ala Ala Gly Lys Ser Ala Ile Asn Ala His 
            260                 265                 270         

Gly Ser Trp Met Ile Gly Gln Tyr Thr Gly Tyr Lys Gly Val Glu Val 
        275                 280                 285             

Gly Ile Ala Pro Thr Pro Val Gly Pro Glu Gly Lys Arg Ala Ser Met 
    290                 295                 300                 

Phe Asn Gly Leu Ala Asp Ser Ile Trp Ala Gly Thr Lys Lys Lys Asp 
305                 310                 315                 320 

Ala Ala Ile Lys Trp Val Glu Tyr Leu Ala Ser Ala Pro Cys Gln Asp 
                325                 330                 335     

Val Val Ala Ser Lys Ala Val Val Phe Pro Ala Leu Lys Ala Ser Ser 
            340                 345                 350         

Glu Lys Ala Ala Glu Ala Phe Lys Ala Lys Gly Val Asp Val Thr Ala 
        355                 360                 365             

Phe Thr Glu His Val Lys Asn Gly Thr Thr Phe Leu Tyr Pro Ile Thr 
    370                 375                 380                 

Asp Asn Thr Ala Lys Val Lys Gly Ile Met Glu Pro Ala Met Asp Ala 
385                 390                 395                 400 

Val Val Ser Gly Lys Lys Pro Ala Ser Ser Leu Thr Glu Ala Asn Asn 
                405                 410                 415     

Gln Val Asn Asp 
            420 

<210>   413
<211>   419
<212>   PRT
<213>   Streptomyces coelicolor A3(2)

<400>   413
Leu Val Ser Cys Gly Ser Ser Asp Glu Ala Gly Asp Gly Arg Thr Thr 
                5                   10                  15      

Val Asp Tyr Trp Leu Trp Asp Asp Leu Gln Leu Pro Ala Tyr Gln Glu 
            20                  25                  30          

Cys Ala Thr Ala Phe Glu Lys Ala Asn Pro Asp Ile Ala Val Arg Ile 
        35                  40                  45              

Thr Gln Thr Ala Trp Asn Gln Tyr Trp Gln Asn Leu Thr Thr Gln Leu 
    50                  55                  60                  

Val Ser Gly Glu Ala Pro Asp Val Trp Thr Asn Gln Ala Thr Tyr Tyr 
65                  70                  75                  80  

Pro Gln Phe Ala Ala Gly Asn Gln Leu Leu Asp Leu Gln Pro Tyr Val 
                85                  90                  95      

Glu Arg Asp Gly Leu Asp Val Ser Ala Tyr Gln Ala Gly Leu Ala Asp 
            100                 105                 110         

Thr Trp Val Lys Asp Asp Lys Arg Tyr Gly Leu Pro Lys Asp Trp Asp 
        115                 120                 125             

Thr Met Ala Val Val Tyr Asn Thr Asp Met Leu Lys Arg Gln Gly Val 
    130                 135                 140                 

Asp Leu Ala Ala Leu Asn Asp Leu Thr Trp Asn Pro Ala Asp Gly Gly 
145                 150                 155                 160 

Thr Leu Glu Gln Val Ile Ala Arg Ala Thr Val Asp Ser Glu Gly Arg 
                165                 170                 175     

Asn Gly Leu Asp Pro Ala Phe Asp Lys Asp His Val Glu Val Tyr Gly 
            180                 185                 190         

Phe Leu Pro Glu Trp Ala Asp Gly Ala Gln Gly Gln Asn Gly Trp Gly 
        195                 200                 205             

Asn Phe Ala Ala Ala Asn Gly Phe Glu Tyr Leu Asp Lys Asn Pro Trp 
    210                 215                 220                 

Gly Thr His Tyr Lys Phe Asp Asp Pro Arg Leu Ala Glu Thr Val Ser 
225                 230                 235                 240 

Trp Phe Arg His Leu Ile Asp Lys Gly Tyr Ala Pro Arg Leu Asp Gln 
                245                 250                 255     

Gln Ser Ser Val Ala Arg Thr Glu Leu Leu Ile Ala Gly Lys Gly Ala 
            260                 265                 270         

Met Ser Leu Ala Gly Ser Phe Thr Val Ser Ser Phe Thr Gly Pro Lys 
        275                 280                 285             

Val Lys Gln Asp Phe Gly Phe Ala Ala Met Pro Val Gly Pro Ala Gly 
    290                 295                 300                 

Arg Lys Ser Ala Leu Asn Gly Leu Ala Asp Ser Val Trp Ala Gly Thr 
305                 310                 315                 320 

Asp His Lys Glu Glu Ala Trp Lys Trp Val Lys Tyr Leu Ala Ser Ala 
                325                 330                 335     

Asp Cys Gln Asp Arg Val Ala Ala His Gly Val Val Phe Pro Ala Leu 
            340                 345                 350         

Lys Ser Ser Thr Glu Lys Ala Leu Ala Ala His Glu Ala Asp Gly Asp 
        355                 360                 365             

Asp Val Arg Ala Phe Thr Asp Ala Val Gly Thr Lys Gly Val Thr Phe 
    370                 375                 380                 

Gln Leu Pro Val Thr Glu His Gly Thr Glu Ile Ser Pro Leu Val Gln 
385                 390                 395                 400 

Asp Ala Ile Gln Ser Ala Ile Leu Gly Gln Glu Asp Ala Ala Asp Ala 
                405                 410                 415     

Leu Glu Ser 
            

<210>   414
<211>   398
<212>   PRT
<213>   Mycobacterium avium subsp. paratuberculosis K-10

<400>   414
Val Trp Gly Asp Glu Leu Ala Glu Ala Tyr Arg Gln Ser Phe Ala Ala 
                5                   10                  15      

Phe Thr Arg Ala His Pro Asp Ile Glu Val His Val Asn Met Val Ala 
            20                  25                  30          

Tyr Ser Thr Tyr Phe Asn Thr Leu Arg Thr Asp Val Ala Gly Gly Ser 
        35                  40                  45              

Ala Asp Asp Ile Phe Trp Leu Ser Asn Ala Tyr Leu Ala Ala Tyr Ala 
    50                  55                  60                  

Asp Ser Gly Arg Leu Leu Asn Ile Leu Asp Thr Leu Gly Thr Asn Ala 
65                  70                  75                  80  

Ala Ala Asp Trp Glu Arg Pro Val Val Glu Gln Phe Thr Arg His Gly 
                85                  90                  95      

Gln Leu Trp Gly Val Pro Gln Leu Thr Asp Ala Gly Ile Ala Leu Tyr 
            100                 105                 110         

Tyr Asn Ala Asp Leu Leu Gly Ala Ala Gly Ile Asp Pro Ala Gln Leu 
        115                 120                 125             

Asn Gly Leu Arg Trp Asp Pro Ala Gly Gly Asp Thr Leu Arg Pro Leu 
    130                 135                 140                 

Leu Ala Arg Leu Thr Val Asp Ala Asp Gly Asn Arg Gly Asp Thr Arg 
145                 150                 155                 160 

Gly Phe Asp Pro Gly Arg Val Arg Gln Trp Gly Tyr Asn Ala Ala Asn 
                165                 170                 175     

Asp Pro Gln Gly Ile Tyr Leu Asn Tyr Ile Gly Ser Ala Gly Gly Val 
            180                 185                 190         

Phe Gln Arg Gly Asp Glu Phe Ala Phe Asp Asn Pro Ala Ala Val Ser 
        195                 200                 205             

Ala Phe Arg Tyr Leu Val Asp Leu Ile Asn Arg Asp His Val Ala Pro 
    210                 215                 220                 

Ser Ala Ala Asp Thr Asn Asp Asn Gly Asp Phe Ser Arg Asn Gln Phe 
225                 230                 235                 240 

Leu Ala Gly Arg Met Ala Leu Phe Gln Ser Gly Thr Tyr Asn Leu Ala 
                245                 250                 255     

Pro Val Ala Arg Asp Ala Arg Phe Arg Trp Gly Val Ala Met Met Pro 
            260                 265                 270         

Ala Gly Pro Val Gly Arg Val Ser Val Thr Asn Gly Ile Ala Ala Ala 
        275                 280                 285             

Gly Asn Ala Ala Thr Lys His Pro Ala Ala Val Arg Gln Val Leu Ala 
    290                 295                 300                 

Trp Met Gly Ser Arg Gln Gly Asn Glu Tyr Leu Gly Arg Tyr Gly Ala 
305                 310                 315                 320 

Ala Ile Pro Ala Val Thr Ser Ala Gln Pro Val Tyr Phe Arg Tyr Trp 
                325                 330                 335     

Ala Ser Arg Gly Val Asp Val Thr Pro Phe Phe Ala Val Leu Asn Gly 
            340                 345                 350         

Pro Arg Ile Ala Ala Pro Gly Gly Ala Gly Phe Ala Ala Gly Asn Asp 
        355                 360                 365             

Ala Leu Arg Pro Tyr Phe Asp Glu Met Phe Ser Gly Arg Gly Asp Val 
    370                 375                 380                 

Ala Thr Thr Leu Arg Arg Ala Gln Ala Ala Ala Asn Ala Ala 
385                 390                 395             

<210>   415
<211>   398
<212>   PRT
<213>   Mycobacterium avium 104

<400>   415
Val Trp Gly Asp Glu Leu Ala Glu Ala Tyr Arg Gln Ser Phe Ala Ala 
                5                   10                  15      

Phe Thr Arg Ala His Pro Asp Ile Glu Val His Val Asn Met Val Ala 
            20                  25                  30          

Tyr Ser Thr Tyr Phe Asn Thr Leu Arg Thr Asp Val Ala Gly Gly Ser 
        35                  40                  45              

Ala Asp Asp Ile Phe Trp Leu Ser Asn Ala Tyr Leu Ala Ala Tyr Ala 
    50                  55                  60                  

Asp Ser Gly Arg Leu Leu Asn Ile Leu Asp Thr Leu Gly Thr Asn Ala 
65                  70                  75                  80  

Ala Ala Asp Trp Glu Arg Pro Val Val Glu Gln Phe Thr Arg His Gly 
                85                  90                  95      

Gln Leu Trp Gly Val Pro Gln Leu Thr Asp Ala Gly Ile Ala Leu Tyr 
            100                 105                 110         

Tyr Asn Ala Asp Leu Leu Gly Ala Ala Gly Ile Asp Pro Ala Gln Leu 
        115                 120                 125             

Asn Ser Leu Arg Trp Asn Pro Ala Gly Gly Asp Thr Leu Arg Pro Leu 
    130                 135                 140                 

Leu Ala Arg Leu Thr Val Asp Ala Asp Gly Asn Arg Gly Asp Thr Arg 
145                 150                 155                 160 

Gly Phe Asp Pro Gly Arg Val Arg Gln Trp Gly Tyr Asn Ala Ala Asn 
                165                 170                 175     

Asp Pro Gln Gly Ile Tyr Leu Asn Tyr Ile Gly Ser Ala Gly Gly Val 
            180                 185                 190         

Phe Gln Arg Gly Asp Glu Phe Ala Phe Asp Asn Pro Ala Ala Val Ser 
        195                 200                 205             

Ala Phe Arg Tyr Leu Val Asp Leu Ile Asn Arg Asp His Val Ala Pro 
    210                 215                 220                 

Pro Ala Ala Asp Thr Asn Asp Asn Gly Asp Phe Ser Arg Asn Gln Phe 
225                 230                 235                 240 

Leu Ala Gly Arg Met Ala Leu Phe Gln Ser Gly Thr Tyr Asn Leu Ala 
                245                 250                 255     

Pro Val Ala Arg Asp Ala Arg Phe Arg Trp Gly Val Ala Met Met Pro 
            260                 265                 270         

Ala Gly Pro Val Gly Arg Val Ser Val Thr Asn Gly Ile Ala Ala Ala 
        275                 280                 285             

Gly Asn Ala Ala Thr Lys His Pro Gly Ala Val Arg Gln Val Leu Ala 
    290                 295                 300                 

Trp Met Gly Ser Arg Gln Gly Asn Glu Tyr Leu Gly Arg Tyr Gly Ala 
305                 310                 315                 320 

Ala Ile Pro Ala Val Thr Ser Ala Gln Pro Val Tyr Phe Gly Tyr Trp 
                325                 330                 335     

Ala Ala Arg Gly Val Asp Val Thr Pro Phe Phe Ala Val Leu Asn Gly 
            340                 345                 350         

Pro Arg Ile Ala Ala Pro Gly Gly Ala Gly Phe Ala Ala Gly Asn Asp 
        355                 360                 365             

Ala Leu Arg Pro Tyr Phe Asp Glu Met Phe Ser Gly Arg Gly Asp Val 
    370                 375                 380                 

Ala Thr Thr Leu Arg Arg Ala Gln Ala Ala Ala Asn Ala Ala 
385                 390                 395             

<210>   416
<211>   460
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   416
Met Asn Arg Asn Gly Lys Lys Val Val Phe Thr Ile Pro Val Val Leu 
                5                   10                  15      

Thr Met Leu Leu Val Gly Cys Gly Thr Ser Thr Ala Asn Lys Pro Gly 
            20                  25                  30          

His Gln Phe Ser Thr Ser Glu Gly Ser Ala Ser Thr Gln Val Val Thr 
        35                  40                  45              

Leu His Tyr Met Leu Trp Asp Pro Asn Glu Glu Ile Gly Tyr Lys Gln 
    50                  55                  60                  

Ser Ile Ala Val Phe Glu Lys Leu His Pro Asn Ile Lys Val Val Ile 
65                  70                  75                  80  

Glu Gln Tyr Pro Trp Ser Gln Tyr Trp Gln Lys Leu Glu Thr Glu Met 
                85                  90                  95      

Ala Ala Gly Thr Ala Pro Asp Val Phe Trp Asp His Val Thr Tyr Phe 
            100                 105                 110         

Pro Thr Phe Val Thr Asn Gly Gln Leu Leu Asn Leu Thr Pro Tyr Ile 
        115                 120                 125             

Lys Ser Ser His Val Asp Ile Arg Glu Tyr Tyr Pro Asn Leu Leu Lys 
    130                 135                 140                 

Gln Tyr Glu Tyr Asn Gly Asn Ile Tyr Gly Leu Pro Lys Asp Trp Asp 
145                 150                 155                 160 

Thr Ile Ala Ile Phe Tyr Asn Lys Lys Leu Phe Glu Lys Asp His Val 
                165                 170                 175     

Pro Phe Pro Thr Asn Leu Thr Trp Asn Pro Arg Asn Gly Gly Thr Leu 
            180                 185                 190         

Val Lys Val Ala Glu Glu Met Thr Val Asp Lys Asn Gly Lys His Pro 
        195                 200                 205             

Gly Gln Pro Gly Phe Asn Pro Asn Gln Ile Val Gln Tyr Gly Phe Met 
    210                 215                 220                 

Ser Tyr Asn Ser Asn Gln Ser Phe Tyr Tyr Asn Phe Leu Ala Glu Asp 
225                 230                 235                 240 

Gly Val Lys Ile Leu Asp His Asn Phe Gly Thr Gln Val Leu Met Asp 
                245                 250                 255     

Thr Pro Gln Ala Ile Gln Thr Met Gln Asn Leu Ile Asp Met Ile Tyr 
            260                 265                 270         

Lys Tyr His Val Ser Pro Ser Gly Ala Glu Gly Ala Asn Val Val Asn 
        275                 280                 285             

Ser Glu Gly Asn Ala Gln Gln Leu Phe Glu Glu Gly Lys Leu Ala Met 
    290                 295                 300                 

Tyr Thr Asp Gly Asp Trp Val Leu Thr Pro Val Val Lys Ala Ser Asn 
305                 310                 315                 320 

Phe Pro Val Gly Ile Ala Pro Leu Pro Val Gly Pro Ile Gly Arg Val 
                325                 330                 335     

Ser Val Met Asn Gly Leu Ser Asp Ala Ile Tyr Ala His Thr Lys Tyr 
            340                 345                 350         

Pro Lys Gln Ala Trp Glu Leu Val Gln Trp Leu Ala Ser Pro Gln Ser 
        355                 360                 365             

Glu Arg Ile Leu Ala Ser Gly Gly Tyr Val Trp Pro Gly Ile Lys Ser 
    370                 375                 380                 

Leu Ala Pro Leu Phe Ala Gln Ala Trp Thr Lys Lys Gly Val Asp Val 
385                 390                 395                 400 

Thr Pro Phe Leu Glu Glu Ser Arg Gly Lys Thr Ile Ser Phe Pro Ile 
                405                 410                 415     

Thr Val Asn Trp Gly Gln Ala Glu Asn Ala Ile Asp Lys Glu Phe Asp 
            420                 425                 430         

Leu Met Trp Leu Gly Lys Val Pro Pro Ser Gln Ala Leu Gln Thr Ala 
        435                 440                 445             

Val Gln Gln Ala Asp Ala Ala Leu Asn Gly Gly Gln 
    450                 455                 460 

<210>   417
<211>   460
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   417
Met Asn Arg Asn Gly Lys Lys Val Val Phe Thr Ile Pro Val Val Leu 
                5                   10                  15      

Thr Met Leu Leu Val Gly Cys Gly Thr Ser Thr Ala Asn Lys Pro Gly 
            20                  25                  30          

His Gln Phe Ser Thr Ser Glu Gly Ser Ala Ser Thr Gln Val Val Thr 
        35                  40                  45              

Leu His Tyr Met Leu Trp Asp Pro Asn Glu Glu Ile Gly Tyr Lys Gln 
    50                  55                  60                  

Ser Ile Ala Val Phe Glu Lys Leu His Pro Asn Ile Lys Val Val Ile 
65                  70                  75                  80  

Glu Gln Tyr Pro Trp Ser Gln Tyr Trp Gln Lys Leu Glu Thr Glu Met 
                85                  90                  95      

Ala Ala Gly Thr Ala Pro Asp Val Phe Trp Asp His Val Thr Tyr Phe 
            100                 105                 110         

Pro Thr Phe Val Thr Asn Gly Gln Leu Leu Asn Leu Thr Pro Tyr Ile 
        115                 120                 125             

Lys Ser Ser His Val Asp Leu Arg Glu Tyr Tyr Pro Asn Leu Leu Lys 
    130                 135                 140                 

Gln Tyr Glu Tyr Asn Gly Asn Ile Tyr Gly Leu Pro Lys Asp Trp Asp 
145                 150                 155                 160 

Thr Ile Ala Ile Phe Tyr Asn Lys Lys Leu Phe Glu Lys Asp His Val 
                165                 170                 175     

Pro Phe Pro Thr Asn Leu Thr Trp Asn Pro Arg Asn Gly Gly Thr Leu 
            180                 185                 190         

Val Lys Val Ala Glu Glu Met Thr Val Asp Lys Asn Gly Lys His Pro 
        195                 200                 205             

Gly Gln Pro Gly Phe Asn Pro Asn Gln Ile Val Gln Tyr Gly Phe Met 
    210                 215                 220                 

Ser Tyr Asn Ser Asn Gln Ser Phe Tyr Tyr Asn Phe Leu Ala Glu Asp 
225                 230                 235                 240 

Gly Val Lys Ile Leu Asp His Asn Phe Gly Thr Gln Val Leu Met Asp 
                245                 250                 255     

Thr Pro Gln Ala Ile Gln Thr Met Gln Asn Leu Ile Asp Met Ile Tyr 
            260                 265                 270         

Lys Tyr His Val Ser Pro Ser Gly Ala Glu Gly Ala Asn Val Val Asn 
        275                 280                 285             

Ser Glu Gly Asn Ala Gln Gln Leu Phe Glu Glu Gly Lys Leu Ala Met 
    290                 295                 300                 

Tyr Thr Asp Gly Asp Trp Val Leu Thr Pro Val Val Lys Ala Ser Asn 
305                 310                 315                 320 

Phe Pro Val Gly Ile Ala Pro Leu Pro Val Gly Pro Ile Gly Arg Val 
                325                 330                 335     

Ser Val Met Asn Gly Leu Ser Asp Ala Ile Tyr Ala His Thr Lys Tyr 
            340                 345                 350         

Pro Lys Gln Ala Trp Glu Leu Val Gln Trp Leu Ala Ser Pro Gln Ser 
        355                 360                 365             

Glu Arg Ile Leu Ala Ser Gly Gly Tyr Val Trp Pro Gly Ile Lys Ser 
    370                 375                 380                 

Leu Ala Pro Leu Phe Ala Gln Ala Trp Thr Lys Lys Gly Val Asp Val 
385                 390                 395                 400 

Thr Pro Phe Leu Glu Glu Ser Arg Gly Lys Thr Leu Ser Phe Pro Ile 
                405                 410                 415     

Thr Val Asn Trp Gly Gln Ala Glu Asn Ala Ile Asp Lys Glu Phe Asp 
            420                 425                 430         

Leu Met Trp Leu Gly Lys Val Pro Pro Ser Gln Ala Leu Gln Thr Ala 
        435                 440                 445             

Val Gln Gln Ala Asp Ala Ala Leu Asn Gly Gly Gln 
    450                 455                 460 

<210>   418
<211>   460
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   418
Met Asn Arg Asn Gly Lys Lys Val Val Phe Thr Ile Pro Val Val Leu 
                5                   10                  15      

Thr Met Leu Leu Val Gly Cys Gly Thr Ser Thr Ala Asn Lys Pro Gly 
            20                  25                  30          

His Gln Phe Ser Thr Ser Glu Gly Ser Ala Ser Thr Gln Val Val Thr 
        35                  40                  45              

Leu His Tyr Met Leu Trp Asp Pro Asn Glu Glu Ile Gly Tyr Lys Gln 
    50                  55                  60                  

Ser Ile Ala Val Phe Glu Lys Leu His Pro Asn Ile Lys Val Val Ile 
65                  70                  75                  80  

Glu Gln Tyr Pro Trp Ser Gln Tyr Trp Gln Lys Leu Glu Thr Glu Met 
                85                  90                  95      

Ala Ala Gly Thr Ala Pro Asp Val Phe Trp Asp His Val Thr Tyr Phe 
            100                 105                 110         

Pro Thr Phe Val Thr Asn Gly Gln Leu Leu Asn Leu Thr Pro Tyr Ile 
        115                 120                 125             

Lys Ser Ser His Val Asp Leu Arg Glu Tyr Tyr Pro Asn Leu Leu Lys 
    130                 135                 140                 

Gln Tyr Glu Tyr Asn Gly Asn Ile Tyr Gly Leu Pro Lys Asp Trp Asp 
145                 150                 155                 160 

Thr Ile Ala Ile Phe Tyr Asn Lys Lys Leu Phe Glu Lys Asp His Val 
                165                 170                 175     

Pro Phe Pro Thr Asn Leu Thr Trp Asn Pro Arg Asn Gly Gly Thr Leu 
            180                 185                 190         

Val Lys Val Ala Glu Glu Met Thr Val Asp Lys Asn Gly Lys His Pro 
        195                 200                 205             

Gly Gln Pro Gly Phe Asn Pro Asn Gln Ile Val Gln Tyr Gly Phe Met 
    210                 215                 220                 

Ser Tyr Asn Ser Asn Gln Ser Phe Tyr Tyr Asn Phe Leu Ala Glu Asp 
225                 230                 235                 240 

Gly Val Lys Ile Leu Asp His Asn Phe Gly Thr Gln Val Leu Met Asp 
                245                 250                 255     

Thr Pro Gln Ala Ile Gln Thr Met Gln Asn Leu Ile Asp Met Ile Tyr 
            260                 265                 270         

Lys Tyr His Val Ser Pro Ser Gly Ala Glu Gly Ala Asn Val Val Asn 
        275                 280                 285             

Ser Glu Gly Asn Ala Gln Gln Leu Phe Glu Glu Gly Lys Leu Ala Met 
    290                 295                 300                 

Tyr Thr Asp Gly Asp Trp Val Leu Thr Pro Ile Val Lys Ala Ser Asn 
305                 310                 315                 320 

Phe Pro Val Gly Ile Ala Pro Leu Pro Val Gly Pro Ile Gly Arg Val 
                325                 330                 335     

Ser Val Met Asn Gly Leu Ser Asp Ala Ile Tyr Ala His Thr Lys Tyr 
            340                 345                 350         

Pro Lys Gln Ala Trp Glu Leu Val Gln Trp Leu Ala Ser Pro Gln Ser 
        355                 360                 365             

Glu Arg Ile Leu Ala Ser Gly Gly Tyr Val Trp Pro Gly Ile Lys Ser 
    370                 375                 380                 

Leu Ala Pro Leu Phe Ala Gln Ala Trp Thr Lys Lys Gly Val Asp Val 
385                 390                 395                 400 

Thr Pro Phe Leu Glu Glu Ser Arg Gly Lys Thr Ile Ser Phe Pro Ile 
                405                 410                 415     

Thr Val Asn Trp Gly Gln Ala Glu Asn Ala Ile Asp Lys Glu Phe Asp 
            420                 425                 430         

Leu Met Trp Leu Gly Lys Val Pro Pro Ser Gln Ala Leu Gln Thr Ala 
        435                 440                 445             

Val Gln Gln Ala Asp Ala Ala Leu Asn Gly Gly Gln 
    450                 455                 460 

<210>   419
<211>   460
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   419
Met Asn Arg Asn Gly Lys Lys Val Val Phe Thr Ile Pro Val Val Leu 
                5                   10                  15      

Thr Met Leu Leu Val Gly Cys Gly Thr Ser Thr Ala Asn Lys Pro Gly 
            20                  25                  30          

His Gln Phe Ser Thr Ser Glu Gly Ser Ala Ser Thr Gln Val Val Thr 
        35                  40                  45              

Leu His Tyr Met Leu Trp Asp Pro Asn Glu Glu Ile Gly Tyr Lys Gln 
    50                  55                  60                  

Ser Ile Ala Val Phe Glu Lys Leu His Pro Asn Ile Lys Val Val Ile 
65                  70                  75                  80  

Glu Gln Tyr Pro Trp Ser Gln Tyr Trp Gln Lys Leu Glu Thr Glu Met 
                85                  90                  95      

Ala Ala Gly Thr Ala Pro Asp Val Phe Trp Asp His Val Thr Tyr Phe 
            100                 105                 110         

Pro Thr Phe Val Thr Asn Gly Gln Leu Leu Asn Leu Thr Pro Tyr Ile 
        115                 120                 125             

Lys Ser Ser His Val Asp Leu Arg Glu Tyr Tyr Pro Asn Leu Leu Lys 
    130                 135                 140                 

Gln Tyr Glu Tyr Asn Gly Asn Ile Tyr Gly Leu Pro Lys Asp Trp Asp 
145                 150                 155                 160 

Thr Ile Ala Ile Phe Tyr Asn Lys Lys Leu Phe Glu Lys Asp His Val 
                165                 170                 175     

Pro Phe Pro Thr Asn Leu Thr Trp Asn Pro Arg Asn Gly Gly Thr Leu 
            180                 185                 190         

Val Lys Val Ala Glu Glu Met Thr Val Asp Lys Asn Gly Lys His Pro 
        195                 200                 205             

Gly Gln Pro Gly Phe Asn Pro Asn Gln Ile Val Gln Tyr Gly Phe Met 
    210                 215                 220                 

Ser Tyr Asn Ser Asn Gln Ser Phe Tyr Tyr Asn Phe Leu Ala Glu Asp 
225                 230                 235                 240 

Gly Val Lys Ile Leu Asp His Asn Phe Gly Thr Gln Val Leu Met Asp 
                245                 250                 255     

Thr Pro Gln Ala Ile Gln Thr Met Gln Asn Leu Ile Asp Met Ile Tyr 
            260                 265                 270         

Arg Tyr His Val Ser Pro Ser Gly Ala Glu Gly Ala Asn Val Val Asn 
        275                 280                 285             

Ser Glu Gly Asn Ala Gln Gln Leu Phe Glu Glu Gly Lys Leu Ala Met 
    290                 295                 300                 

Tyr Thr Asp Gly Asp Trp Val Leu Thr Pro Val Val Lys Ala Ser Asn 
305                 310                 315                 320 

Phe Pro Val Gly Ile Ala Pro Leu Pro Val Gly Pro Ile Gly Arg Val 
                325                 330                 335     

Ser Val Met Asn Gly Leu Ser Asp Ala Ile Tyr Ala His Thr Lys Tyr 
            340                 345                 350         

Pro Lys Gln Ala Trp Glu Leu Val Gln Trp Leu Ala Ser Pro Gln Ser 
        355                 360                 365             

Glu Arg Ile Leu Ala Ser Gly Gly Tyr Val Trp Pro Gly Ile Lys Ser 
    370                 375                 380                 

Leu Ala Pro Leu Phe Ala Gln Ala Trp Thr Lys Lys Gly Val Asp Val 
385                 390                 395                 400 

Thr Pro Phe Leu Glu Glu Ser Arg Gly Lys Thr Ile Ser Phe Pro Ile 
                405                 410                 415     

Thr Val Asn Trp Gly Gln Ala Glu Asn Ala Ile Asp Lys Glu Phe Asp 
            420                 425                 430         

Leu Met Trp Leu Gly Lys Val Pro Pro Ser Gln Ala Leu Gln Thr Ala 
        435                 440                 445             

Val Gln Gln Ala Asp Ala Ala Leu Asn Gly Gly Gln 
    450                 455                 460 

<210>   420
<211>   460
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 409

<400>   420
Met Asn Arg Asn Gly Lys Lys Val Val Phe Thr Ile Pro Val Val Leu 
                5                   10                  15      

Thr Met Leu Leu Val Gly Cys Gly Thr Ser Thr Ala Asn Lys Pro Gly 
            20                  25                  30          

His Gln Phe Ser Thr Ser Glu Gly Ser Ala Ser Thr Gln Val Val Thr 
        35                  40                  45              

Leu His Tyr Met Leu Trp Asp Pro Asn Glu Glu Ile Gly Tyr Lys Gln 
    50                  55                  60                  

Ser Ile Ala Val Phe Glu Lys Leu His Pro Asn Ile Lys Val Val Ile 
65                  70                  75                  80  

Glu Gln Tyr Pro Trp Ser Gln Tyr Trp Gln Lys Leu Glu Thr Glu Met 
                85                  90                  95      

Ala Ala Gly Thr Ala Pro Asp Val Phe Trp Asp His Val Thr Tyr Phe 
            100                 105                 110         

Pro Thr Phe Val Thr Asn Gly Gln Leu Leu Asn Leu Thr Pro Tyr Ile 
        115                 120                 125             

Lys Ser Ser His Val Asp Leu Arg Glu Tyr Tyr Pro Asn Leu Leu Lys 
    130                 135                 140                 

Gln Tyr Glu Tyr Asn Gly Asn Ile Tyr Gly Leu Pro Lys Asp Trp Asp 
145                 150                 155                 160 

Thr Ile Ala Ile Phe Tyr Asn Lys Lys Leu Phe Glu Lys Asp His Val 
                165                 170                 175     

Pro Phe Pro Thr Asn Leu Thr Trp Asn Pro Arg Asn Gly Gly Thr Leu 
            180                 185                 190         

Val Lys Val Ala Glu Glu Met Thr Val Asp Lys Asn Gly Lys His Pro 
        195                 200                 205             

Gly Gln Pro Gly Phe Asn Pro Asn Gln Ile Val Gln Tyr Gly Phe Met 
    210                 215                 220                 

Ser Tyr Asn Ser Asn Gln Ser Phe Tyr Tyr Asn Phe Leu Ala Glu Asp 
225                 230                 235                 240 

Gly Val Lys Ile Leu Asp His Asn Phe Gly Thr Gln Val Leu Met Asp 
                245                 250                 255     

Thr Pro Gln Ala Ile Gln Thr Met Gln Asn Leu Ile Asp Met Ile Tyr 
            260                 265                 270         

Lys Tyr His Val Ser Pro Ser Gly Ala Glu Gly Ala Asn Val Val Asn 
        275                 280                 285             

Ser Glu Gly Asn Ala Gln Gln Leu Phe Glu Glu Gly Lys Leu Ala Met 
    290                 295                 300                 

Tyr Thr Asp Gly Asp Trp Val Leu Thr Pro Val Val Lys Ala Ser Asn 
305                 310                 315                 320 

Phe Pro Val Gly Ile Ala Pro Leu Pro Val Gly Pro Ile Gly Arg Val 
                325                 330                 335     

Ser Val Met Asn Gly Leu Ser Asp Ala Ile Tyr Ala His Thr Lys Tyr 
            340                 345                 350         

Pro Lys Gln Ala Trp Glu Leu Val Gln Trp Leu Ala Ser Pro Asn Ser 
        355                 360                 365             

Glu Arg Ile Leu Ala Ser Gly Gly Tyr Val Trp Pro Gly Ile Lys Ser 
    370                 375                 380                 

Leu Ala Pro Leu Phe Ala Gln Ala Trp Thr Lys Lys Gly Val Asp Val 
385                 390                 395                 400 

Thr Pro Phe Leu Glu Glu Ser Arg Gly Lys Thr Ile Ser Phe Pro Ile 
                405                 410                 415     

Thr Val Asn Trp Gly Gln Ala Glu Asn Ala Ile Asp Lys Glu Phe Asp 
            420                 425                 430         

Leu Met Trp Leu Gly Lys Val Pro Pro Ser Gln Ala Leu Gln Thr Ala 
        435                 440                 445             

Val Gln Gln Ala Asp Ala Ala Leu Asn Gly Gly Gln 
    450                 455                 460 

<210>   421
<211>   1383
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   421
atgaatcgta atggaaagaa ggttgttttt actattccgg ttgttctgac gatgctccta       60

gttggatgtg gtacatcaac tgcgaataag cctggtcatc agttctcaac gagtgaaggc      120

agtgcttcta cccaagttgt cacgttacat tacatgctct gggatccgaa cgaggaaatc      180

ggttacaagc agtccatcgc cgtctttgaa aagttacatc cgaatatcaa agttgtcatc      240

gaacagtacc cgtggtctca gtattggcaa aaattagaga ctgaaatggc ggcagggaca      300

gctcccgacg tgttttggga tcatgttact tatttcccta cttttgttac gaacggtcaa      360

cttctcaatt tgacgcctta tattaagagt tcccatgtcg atattagaga atattatccg      420

aacttgctga agcagtacga gtacaacgga aatatttatg gcctgccaaa ggactgggac      480

acgatagcca tattttataa caagaagctg ttcgaaaagg atcatgttcc atttccaaca      540

aacttgactt ggaatcctag aaatggtgga acattggtca aggttgctga agaaatgacc      600

gtagataaga acggaaaaca cccgggccag ccagggttca atccgaacca aatcgtacaa      660

tacggattta tgtcatataa ctcaaatcag tcattttatt acaacttttt ggccgaagac      720

ggagtgaaaa tcctagacca taacttcggg actcaggtgc taatggacac cccgcaggcc      780

attcagacca tgcagaatct tattgacatg atttacaagt accatgtatc gccttctgga      840

gccgagggag ctaacgttgt aaatagtgaa ggaaatgctc agcaattatt tgaagaaggt      900

aagctggcga tgtacaccga tggcgattgg gtcctgacac ctgtcgtgaa ggcaagcaat      960

ttccctgtcg ggatagctcc gctacctgtc gggccaatag gtcgtgtgtc tgtcatgaac     1020

ggactgtcgg acgccatcta tgcgcatacg aagtacccaa agcaagcgtg ggaactggtt     1080

cagtggctgg cgagtccgca atctgagcgg atcctcgcat cgggtggtta cgtatggcct     1140

gggatcaagt cgttggcacc actgtttgca caggcctgga ccaagaaagg cgtcgatgtc     1200

acgccgttcc tcgaagaatc gaggggtaag accatatcgt tccccatcac tgtgaactgg     1260

gggcaagctg agaacgcgat cgacaaagaa ttcgatttaa tgtggctagg gaaagtgccc     1320

ccgtctcagg cgctccaaac agccgtgcag caggcggatg cggcactgaa tggcggtcag     1380

tga                                                                   1383


<210>   422
<211>   1383
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   422
atgaatcgta atggaaagaa ggttgttttt actattccgg ttgttctgac gatgctccta       60

gttggatgtg gtacatcaac tgcgaataag cctggtcatc agttctcaac gagtgaaggc      120

agtgcttcta cccaagttgt cacgttacat tacatgctct gggatccgaa cgaggaaatc      180

ggttacaagc agtccatcgc cgtctttgaa aagttacatc cgaatatcaa agttgtcatc      240

gaacagtacc cgtggtctca gtattggcaa aaattagaga ctgaaatggc ggcagggaca      300

gctcccgacg tgttttggga tcatgttact tatttcccta cttttgttac gaacggtcaa      360

cttctcaatt tgacgcctta tattaagagt tcccatgtcg atttgagaga atattatccg      420

aacttgctga agcagtacga gtacaacgga aatatttatg gcctgccaaa ggactgggac      480

acgatagcca tattttataa caagaagctg ttcgaaaagg atcatgttcc atttccaaca      540

aacttgactt ggaatcctag aaatggtgga acattggtca aggttgctga agaaatgacc      600

gtagataaga acggaaaaca cccgggccag ccagggttca atccgaacca aatcgtacaa      660

tacggattta tgtcatataa ctcaaatcag tcattttatt acaacttttt ggccgaagac      720

ggagtgaaaa tcctagacca taacttcggg actcaggtgc taatggacac cccgcaggcc      780

attcagacca tgcagaatct tattgacatg atttacaagt accatgtatc gccttctgga      840

gccgagggag ctaacgttgt aaatagtgaa ggaaatgctc agcaattatt tgaagaaggt      900

aagctggcga tgtacaccga tggcgattgg gtcctgacac ctgtcgtgaa ggcaagcaat      960

ttccctgtcg ggatagctcc gctacctgtc gggccaatag gtcgtgtgtc tgtcatgaac     1020

ggactgtcgg acgccatcta tgcgcatacg aagtacccaa agcaagcgtg ggaactggtt     1080

cagtggctgg cgagtccgca atctgagcgg atcctcgcat cgggtggtta cgtatggcct     1140

gggatcaagt cgttggcacc actgtttgca caggcctgga ccaagaaagg cgtcgatgtc     1200

acgccgttcc tcgaagaatc gaggggtaag accttatcgt tccccatcac tgtgaactgg     1260

gggcaagctg agaacgcgat cgacaaagaa ttcgatttaa tgtggctagg gaaagtgccc     1320

ccgtctcagg cgctccaaac agccgtgcag caggcggatg cggcactgaa tggcggtcag     1380

tga                                                                   1383


<210>   423
<211>   1383
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   423
atgaatcgta atggaaagaa ggttgttttt actattccgg ttgttctgac gatgctccta       60

gttggatgtg gtacatcaac tgcgaataag cctggtcatc agttctcaac gagtgaaggc      120

agtgcttcta cccaagttgt cacgttacat tacatgctct gggatccgaa cgaggaaatc      180

ggttacaagc agtccatcgc cgtctttgaa aagttacatc cgaatatcaa agttgtcatc      240

gaacagtacc cgtggtctca gtattggcaa aaattagaga ctgaaatggc ggcagggaca      300

gctcccgacg tgttttggga tcatgttact tatttcccta cttttgttac gaacggtcaa      360

cttctcaatt tgacgcctta tattaagagt tcccatgtcg atttgagaga atattatccg      420

aacttgctga agcagtacga gtacaacgga aatatttatg gcctgccaaa ggactgggac      480

acgatagcca tattttataa caagaagctg ttcgaaaagg atcatgttcc atttccaaca      540

aacttgactt ggaatcctag aaatggtgga acattggtca aggttgctga agaaatgacc      600

gtagataaga acggaaaaca cccgggccag ccagggttca atccgaacca aatcgtacaa      660

tacggattta tgtcatataa ctcaaatcag tcattttatt acaacttttt ggccgaagac      720

ggagtgaaaa tcctagacca taacttcggg actcaggtgc taatggacac cccgcaggcc      780

attcagacca tgcagaatct tattgacatg atttacaagt accatgtatc gccttctgga      840

gccgagggag ctaacgttgt aaatagtgaa ggaaatgctc agcaattatt tgaagaaggt      900

aagctggcga tgtacaccga tggcgattgg gtcctgacac ctattgtgaa ggcaagcaat      960

ttccctgtcg ggatagctcc gctacctgtc gggccaatag gtcgtgtgtc tgtcatgaac     1020

ggactgtcgg acgccatcta tgcgcatacg aagtacccaa agcaagcgtg ggaactggtt     1080

cagtggctgg cgagtccgca atctgagcgg atcctcgcat cgggtggtta cgtatggcct     1140

gggatcaagt cgttggcacc actgtttgca caggcctgga ccaagaaagg cgtcgatgtc     1200

acgccgttcc tcgaagaatc gaggggtaag accatatcgt tccccatcac tgtgaactgg     1260

gggcaagctg agaacgcgat cgacaaagaa ttcgatttaa tgtggctagg gaaagtgccc     1320

ccgtctcagg cgctccaaac agccgtgcag caggcggatg cggcactgaa tggcggtcag     1380

tga                                                                   1383


<210>   424
<211>   1383
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   424
atgaatcgta atggaaagaa ggttgttttt actattccgg ttgttctgac gatgctccta       60

gttggatgtg gtacatcaac tgcgaataag cctggtcatc agttctcaac gagtgaaggc      120

agtgcttcta cccaagttgt cacgttacat tacatgctct gggatccgaa cgaggaaatc      180

ggttacaagc agtccatcgc cgtctttgaa aagttacatc cgaatatcaa agttgtcatc      240

gaacagtacc cgtggtctca gtattggcaa aaattagaga ctgaaatggc ggcagggaca      300

gctcccgacg tgttttggga tcatgttact tatttcccta cttttgttac gaacggtcaa      360

cttctcaatt tgacgcctta tattaagagt tcccatgtcg atttgagaga atattatccg      420

aacttgctga agcagtacga gtacaacgga aatatttatg gcctgccaaa ggactgggac      480

acgatagcca tattttataa caagaagctg ttcgaaaagg atcatgttcc atttccaaca      540

aacttgactt ggaatcctag aaatggtgga acattggtca aggttgctga agaaatgacc      600

gtagataaga acggaaaaca cccgggccag ccagggttca atccgaacca aatcgtacaa      660

tacggattta tgtcatataa ctcaaatcag tcattttatt acaacttttt ggccgaagac      720

ggagtgaaaa tcctagacca taacttcggg actcaggtgc taatggacac cccgcaggcc      780

attcagacca tgcagaatct tattgacatg atttaccgtt accatgtatc gccttctgga      840

gccgagggag ctaacgttgt aaatagtgaa ggaaatgctc agcaattatt tgaagaaggt      900

aagctggcga tgtacaccga tggcgattgg gtcctgacac ctgtcgtgaa ggcaagcaat      960

ttccctgtcg ggatagctcc gctacctgtc gggccaatag gtcgtgtgtc tgtcatgaac     1020

ggactgtcgg acgccatcta tgcgcatacg aagtacccaa agcaagcgtg ggaactggtt     1080

cagtggctgg cgagtccgca atctgagcgg atcctcgcat cgggtggtta cgtatggcct     1140

gggatcaagt cgttggcacc actgtttgca caggcctgga ccaagaaagg cgtcgatgtc     1200

acgccgttcc tcgaagaatc gaggggtaag accatatcgt tccccatcac tgtgaactgg     1260

gggcaagctg agaacgcgat cgacaaagaa ttcgatttaa tgtggctagg gaaagtgccc     1320

ccgtctcagg cgctccaaac agccgtgcag caggcggatg cggcactgaa tggcggtcag     1380

tga                                                                   1383


<210>   425
<211>   1383
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 410

<400>   425
atgaatcgta atggaaagaa ggttgttttt actattccgg ttgttctgac gatgctccta       60

gttggatgtg gtacatcaac tgcgaataag cctggtcatc agttctcaac gagtgaaggc      120

agtgcttcta cccaagttgt cacgttacat tacatgctct gggatccgaa cgaggaaatc      180

ggttacaagc agtccatcgc cgtctttgaa aagttacatc cgaatatcaa agttgtcatc      240

gaacagtacc cgtggtctca gtattggcaa aaattagaga ctgaaatggc ggcagggaca      300

gctcccgacg tgttttggga tcatgttact tatttcccta cttttgttac gaacggtcaa      360

cttctcaatt tgacgcctta tattaagagt tcccatgtcg atttgagaga atattatccg      420

aacttgctga agcagtacga gtacaacgga aatatttatg gcctgccaaa ggactgggac      480

acgatagcca tattttataa caagaagctg ttcgaaaagg atcatgttcc atttccaaca      540

aacttgactt ggaatcctag aaatggtgga acattggtca aggttgctga agaaatgacc      600

gtagataaga acggaaaaca cccgggccag ccagggttca atccgaacca aatcgtacaa      660

tacggattta tgtcatataa ctcaaatcag tcattttatt acaacttttt ggccgaagac      720

ggagtgaaaa tcctagacca taacttcggg actcaggtgc taatggacac cccgcaggcc      780

attcagacca tgcagaatct tattgacatg atttacaagt accatgtatc gccttctgga      840

gccgagggag ctaacgttgt aaatagtgaa ggaaatgctc agcaattatt tgaagaaggt      900

aagctggcga tgtacaccga tggcgattgg gtcctgacac ctgtcgtgaa ggcaagcaat      960

ttccctgtcg ggatagctcc gctacctgtc gggccaatag gtcgtgtgtc tgtcatgaac     1020

ggactgtcgg acgccatcta tgcgcatacg aagtacccaa agcaagcgtg ggaactggtt     1080

cagtggctgg cgagtccgaa ttctgagcgg atcctcgcat cgggtggtta cgtatggcct     1140

gggatcaagt cgttggcacc actgtttgca caggcctgga ccaagaaagg cgtcgatgtc     1200

acgccgttcc tcgaagaatc gaggggtaag accatatcgt tccccatcac tgtgaactgg     1260

gggcaagctg agaacgcgat cgacaaagaa ttcgatttaa tgtggctagg gaaagtgccc     1320

ccgtctcagg cgctccaaac agccgtgcag caggcggatg cggcactgaa tggcggtcag     1380

tga                                                                   1383


<210>   426
<211>   312
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   426
Met Arg Ile Met Gly Ile Asp Ala Ser Ala Arg Leu Thr Arg Gln Val 
                5                   10                  15      

Glu Thr Asn Ala Ser Tyr Asn Ile Gly Arg Arg Leu Ala Pro Tyr Ala 
            20                  25                  30          

Phe Ile Phe Pro Ser Phe Ile Gly Val Leu Ala Phe Leu Leu Val Pro 
        35                  40                  45              

Ala Val Ala Val Leu Ile Ile Ser Leu Phe Asn Trp Asn Met Leu Ser 
    50                  55                  60                  

Pro Pro Lys Phe Val Gly Leu Arg Asn Tyr Leu Asp Ile Phe Gln Asp 
65                  70                  75                  80  

Pro Leu Ala Leu His Ser Met Leu Val Thr Val Tyr Tyr Val Leu Leu 
                85                  90                  95      

Asn Ile Pro Val Gln Thr Val Leu Ala Ile Leu Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Arg Arg Leu Pro Gly Met Gly Met Phe Arg Ala Phe Phe Val Leu 
        115                 120                 125             

Pro Trp Leu Ala Met Pro Val Ala Ile Ser Val Val Trp Asn Leu Ile 
    130                 135                 140                 

Phe Asp Pro Thr Asn Gly Val Leu Asn Asp Val Leu Thr Ala Val Gly 
145                 150                 155                 160 

Leu His Pro Gln Gln Trp Leu Ser Ser Pro Val Glu Ala Leu Pro Cys 
                165                 170                 175     

Val Ala Ala Val Asn Ile Trp Gln Trp Thr Gly Tyr Asn Met Leu Phe 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Ile Pro Ser His Leu Tyr Glu Ala Ala 
        195                 200                 205             

Asn Ile Asp Gly Ala Gly Arg Leu Arg Lys Phe Phe Ser Ile Thr Leu 
    210                 215                 220                 

Pro Leu Leu Arg Pro Thr Leu Leu Phe Val Leu Ile Thr Ser Val Ile 
225                 230                 235                 240 

Gly Ser Phe Gln Val Phe Asp Thr Val Tyr Val Met Thr Gln Gly Gly 
                245                 250                 255     

Pro Gly Thr Ala Thr Asn Val Tyr Asn Tyr Tyr Ile Phe Gln Gln Gly 
            260                 265                 270         

Phe Gln Phe Phe His Met Gly Tyr Ala Ala Ala Leu Ser Val Ile Leu 
        275                 280                 285             

Phe Val Val Ile Leu Leu Val Thr Leu Ile Gln Phe Arg Phe Val Gly 
    290                 295                 300                 

Lys Gly Ala Thr Tyr Asp Met Ser 
305                 310         

<210>   427
<211>   939
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   427
gtgagaatta tggggatcga cgccagcgct cggctgactc ggcaagtaga aacaaatgct       60

tcatacaaca tcggcaggcg actggctcct tacgccttta tattcccgag tttcatagga      120

gtattggcgt ttcttcttgt acctgctgtc gcagtgctga ttataagcct cttcaattgg      180

aatatgttat caccccctaa atttgttggg cttcgtaact atcttgacat ctttcaagat      240

ccccttgcac tccactccat gcttgtgaca gtgtattatg ttttgctcaa tattccggtc      300

caaactgtgt tggccatttt gcttgcgctt ttgttgaacc gcagacttcc gggaatgggg      360

atgtttcgag cgttctttgt ccttccttgg ctggccatgc cggtagctat ctcagtggtg      420

tggaacttga tctttgatcc aaccaatggc gttctcaatg acgtgttaac tgccgttggc      480

ctgcacccgc agcagtggct ttcatcgcca gtagaagccc tgccttgcgt tgctgcagta      540

aacatatggc aatggaccgg gtataacatg ctctttttcc ttgcggggct acaaagtatc      600

ccgtcccatc tttatgaagc agcgaatatc gatggggcgg ggcgactgcg aaagttcttt      660

tcaatcacct tgccactgct caggccgaca ctgttgttcg tgctgatcac gagtgtgatc      720

ggctcctttc aagtgttcga cactgtctat gtgatgacac aaggaggtcc cggtacagcg      780

acgaacgttt acaactacta tatattccag cagggatttc agttttttca catgggctat      840

gctgcggcgt tgtcagtcat tctgtttgtc gtgattctct tggttacact tatccaattc      900

cgttttgtgg gcaaaggagc aacatacgac atgagttga                             939


<210>   428
<211>   257
<212>   PRT
<213>   Reinekea sp. MED297

<400>   428
Asn Ile Arg Ser Ser Leu Ile Gly Phe Gly Leu Ile Phe Pro Ala Leu 
                5                   10                  15      

Val Gly Phe Ser Leu Phe Tyr Ala Trp Pro Ala Ile Arg Ala Ile Ala 
            20                  25                  30          

Ile Ser Phe Thr Asp Trp Asn Leu Leu Ser Glu Pro Thr Phe Val Gly 
        35                  40                  45              

Phe Asp Asn Tyr Ile Glu Met Val Gln Asp Gly Gln Phe Trp Asn Gly 
    50                  55                  60                  

Met Lys Leu Ser Ala Tyr Tyr Val Leu Leu Asn Ile Pro Leu Gln Val 
65                  70                  75                  80  

Val Leu Gly Leu Phe Leu Ala Val Ala Met Asp Arg Leu Thr Arg Ser 
                85                  90                  95      

Leu Phe Val Lys Ala Thr Val Leu Leu Pro Tyr Leu Leu Ser Asn Val 
            100                 105                 110         

Leu Val Ala Met Val Trp Leu Trp Met Leu Asp Pro Ile Leu Gly Ile 
        115                 120                 125             

Val Asn Phe Phe Leu Asp Ala Ile Gly Ile Gly Arg Gln Ser Phe Leu 
    130                 135                 140                 

Gly Asp Pro Glu Gln Ala Leu Ile Ser Val Ala Ala Ile Asn Ile Trp 
145                 150                 155                 160 

Arg His Met Gly Leu Cys Ala Met Leu Phe Leu Ala Gly Leu Gln Thr 
                165                 170                 175     

Ile Pro Arg Tyr Leu Tyr Glu Ala Ala Ser Leu Glu Gly Ala Ser Glu 
            180                 185                 190         

Trp Lys Met Phe Arg Met Ile Thr Leu Pro Leu Leu Arg Pro Val Met 
        195                 200                 205             

Val Phe Val Leu Val Thr Ser Val Thr Gly Ser Phe Gln Ile Phe Asp 
    210                 215                 220                 

Thr Ile Ala Val Thr Thr Met Gly Gly Pro Met Asp Ser Thr Arg Val 
225                 230                 235                 240 

Ile Val Tyr Tyr Ile Ile Gln Asn Ala Phe Ser Phe Tyr Lys Met Gly 
                245                 250                 255     

Tyr 
    

<210>   429
<211>   249
<212>   PRT
<213>   Enterococcus faecalis V583

<400>   429
Ser Phe Ile Ala Pro Asn Phe Ile Gly Phe Phe Leu Phe Thr Leu Ile 
                5                   10                  15      

Pro Val Ile Cys Ser Leu Ile Leu Ala Phe Met Ser Trp Asp Ser Phe 
            20                  25                  30          

Ser Thr Pro Glu Phe Val Gly Met Lys Asn Phe Thr Lys Met Ile His 
        35                  40                  45              

Asp Asp Thr Phe Trp Ile Ser Leu Lys Gln Thr Phe Ile Tyr Thr Ile 
    50                  55                  60                  

Gly Val Val Pro Leu Thr Leu Ile Cys Ser Leu Gly Leu Ala Ile Leu 
65                  70                  75                  80  

Leu Asn Arg Lys Ile Arg Gly Met Lys Phe Phe Arg Thr Ala Phe Phe 
                85                  90                  95      

Phe Pro Tyr Val Thr Ser Leu Val Ala Ile Ala Val Val Trp Asn Met 
            100                 105                 110         

Leu Phe His Pro Thr Met Gly Pro Ile Asn Gln Phe Leu Lys Leu Phe 
        115                 120                 125             

Ile Glu Asn Pro Pro Gly Trp Thr Ser Ser Ser Thr Trp Ala Leu Pro 
    130                 135                 140                 

Ala Ile Ile Ile Val Ser Val Trp Arg Phe Met Gly Tyr Tyr Met Ile 
145                 150                 155                 160 

Leu Tyr Leu Ala Gly Leu Gln Ser Val Pro Arg Glu Leu Tyr Glu Ala 
                165                 170                 175     

Ala Ser Met Asp Gly Ala Gly Lys Trp Asn Gln Phe Leu Asn Val Thr 
            180                 185                 190         

Leu Pro Ser Leu Arg Pro Thr Thr Phe Phe Val Thr Ile Met Leu Val 
        195                 200                 205             

Ile Asn Cys Phe Lys Val Phe Asp Leu Val Gln Val Met Thr Gly Gly 
    210                 215                 220                 

Gly Pro Gly Arg Ala Thr Asn Val Leu Val Tyr Glu Ile Tyr Asn Glu 
225                 230                 235                 240 

Ala Phe Val Lys Phe Asn Phe Gly Tyr 
                245                 

<210>   430
<211>   285
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   430
Lys Thr Leu Ala Phe Tyr Leu Phe Ile Ser Pro Trp Leu Ile Gly Phe 
                5                   10                  15      

Leu Ala Leu Ala Ala Gly Pro Met Ile Tyr Ser Phe Tyr Met Ser Phe 
            20                  25                  30          

Thr Glu Trp Gln Val Met Gly Gly Ala Glu Trp Ile Gly Leu Glu Asn 
        35                  40                  45              

Tyr Glu Arg Leu Phe Phe His Asp Pro Leu Phe Trp Lys Thr Met Trp 
    50                  55                  60                  

Asn Thr Phe Phe Tyr Thr Phe Leu Gly Val Pro Leu Gly Leu Ala Phe 
65                  70                  75                  80  

Gly Tyr Leu Leu Ala Val Leu Leu Asn Gln Lys Val Lys Phe Met Gly 
                85                  90                  95      

Val Phe Arg Thr Ile Phe Tyr Leu Pro Ser Ile Val Pro Ala Val Ala 
            100                 105                 110         

Ser Ser Leu Leu Trp Val Leu Ile Phe Gln Pro Glu Phe Gly Leu Ala 
        115                 120                 125             

Asn Ala Leu Leu Asp Ser Val Gly Leu Pro Thr Ser Arg Trp Leu Leu 
    130                 135                 140                 

Ser Glu Ser Met Val Lys Pro Ala Leu Ile Ile Met Ser Leu Trp Gly 
145                 150                 155                 160 

Val Gly Gly Gly Met Ile Ile Tyr Leu Ala Gly Leu Gln Gly Val Pro 
                165                 170                 175     

Pro Ser Leu Tyr Glu Ala Ala Glu Ile Asp Gly Ala Gly Lys Trp Arg 
            180                 185                 190         

Lys Phe Trp His Ile Thr Ile Pro Met Thr Ser His Val Ile Phe Phe 
        195                 200                 205             

Asn Leu Ile Met Gly Val Ile Gly Ser Phe Gln Val Phe Thr Gln Ala 
    210                 215                 220                 

Tyr Val Met Ser Gly Gly Gly Pro Asn Tyr Ala Ser Leu Phe Tyr Val 
225                 230                 235                 240 

Leu Tyr Leu Tyr Gln Asn Ala Phe Glu Phe Phe Asn Met Gly Tyr Ala 
                245                 250                 255     

Ser Ala Leu Ala Trp Val Leu Phe Val Ile Val Leu Ile Phe Thr Leu 
            260                 265                 270         

Leu Gln Phe Lys Phe Phe Gly Lys Lys Val Tyr Tyr Glu 
        275                 280                 285 

<210>   431
<211>   253
<212>   PRT
<213>   Streptomyces coelicolor A3(2)

<400>   431
Arg Lys Ala Ala Trp Leu Phe Leu Ala Pro Ala Leu Leu Gly Phe Ala 
                5                   10                  15      

Leu Phe Tyr Ala Tyr Pro Thr Val Arg Gly Ile Tyr Tyr Ser Leu Thr 
            20                  25                  30          

Asp Tyr Ser Leu Ile Ala Thr Pro Asp Phe Val Gly Gly Asp Asn Tyr 
        35                  40                  45              

Ser Arg Leu Ile Gly Asp Glu Gln Phe Trp Asn Ala Leu Gln Val Thr 
    50                  55                  60                  

Gly Tyr Tyr Val Leu Val Asn Ile Val Ser Gln Thr Leu Leu Ala Leu 
65                  70                  75                  80  

Val Leu Ala Thr Leu Met His Arg Leu Thr Arg Ser Val Ala Leu Arg 
                85                  90                  95      

Ala Met Leu Leu Val Pro Trp Leu Val Pro Asn Val Thr Val Gly Leu 
            100                 105                 110         

Leu Trp Met Trp Leu Leu Asp Thr Asn Leu Gly Leu Val Asn His Val 
        115                 120                 125             

Leu Asn Ser Met Gly Met Gly Thr Thr Gly Phe Phe Thr Ser Pro Asp 
    130                 135                 140                 

Trp Ala Met Pro Ser Val Ala Ala Val Asn Thr Trp Ala Tyr Thr Gly 
145                 150                 155                 160 

Tyr Thr Ala Leu Leu Leu Tyr Ala Gly Met Leu Gln Val Pro Gln Tyr 
                165                 170                 175     

Leu Tyr Glu Ser Ala Ser Leu Asp Gly Ala Gly Glu Trp Arg Met Phe 
            180                 185                 190         

Thr Arg Ile Thr Leu Pro Leu Leu Arg Pro Val Leu Ser Leu Val Leu 
        195                 200                 205             

Val Val Ser Leu Ile Gly Ser Phe Gln Ile Phe Asp Thr Ile Ala Val 
    210                 215                 220                 

Thr Thr Lys Gly Gly Pro Val Ser Ala Thr Arg Val Ile Tyr Tyr Tyr 
225                 230                 235                 240 

Ile Tyr Glu Gln Ala Phe Thr Asn Phe His Met Gly Tyr 
                245                 250             

<210>   432
<211>   244
<212>   PRT
<213>   Mycobacterium tuberculosis CDC1551

<400>   432
Arg Thr Ala Leu Ala Tyr Ala Leu Leu Ala Pro Ser Leu Val Gly Val 
                5                   10                  15      

Val Ala Phe Leu Leu Leu Pro Ile Leu Val Val Val Trp Leu Ser Leu 
            20                  25                  30          

His Arg Trp Asp Leu Leu Gly Pro Leu Arg Tyr Val Gly Leu Thr Asn 
        35                  40                  45              

Trp Arg Ser Val Leu Thr Asp Ser Gly Phe Ala Asp Ser Leu Val Val 
    50                  55                  60                  

Thr Ala Val Phe Val Ala Ile Val Val Pro Ala Gln Thr Val Leu Gly 
65                  70                  75                  80  

Leu Leu Ala Ala Ser Leu Leu Ala Arg Arg Leu Pro Gly Thr Gly Leu 
                85                  90                  95      

Phe Arg Thr Leu Tyr Val Leu Pro Trp Ile Cys Ala Pro Leu Ala Ile 
            100                 105                 110         

Ala Val Met Trp Arg Trp Ile Leu Ala Pro Thr Asp Gly Ala Ile Ser 
        115                 120                 125             

Thr Val Leu Gly His Arg Ile Glu Trp Leu Thr Asp Pro Gly Leu Ala 
    130                 135                 140                 

Leu Pro Val Val Ser Ala Val Val Val Trp Thr Asn Val Gly Tyr Val 
145                 150                 155                 160 

Ser Leu Phe Phe Leu Ala Gly Leu Met Ala Ile Pro Gln Asp Ile His 
                165                 170                 175     

Asn Ala Ala Arg Thr Asp Gly Ala Ser Ala Trp Gln Arg Phe Trp Arg 
            180                 185                 190         

Ile Thr Leu Pro Met Leu Arg Pro Thr Met Phe Phe Val Leu Val Thr 
        195                 200                 205             

Gly Ile Ile Ser Ala Ala Gln Val Phe Asp Thr Val Tyr Ala Leu Thr 
    210                 215                 220                 

Gly Gly Gly Pro Gln Gly Ser Thr Asp Leu Val Ala His Arg Ile Tyr 
225                 230                 235                 240 

Ala Glu Ala Phe 
                

<210>   433
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   433
Met Arg Ile Met Gly Ile Asp Ala Ser Ala Arg Leu Thr Arg Gln Val 
                5                   10                  15      

Glu Thr Asn Ala Ser Tyr Asn Ile Gly Arg Arg Leu Ala Pro Tyr Ala 
            20                  25                  30          

Phe Ile Phe Pro Ser Phe Ile Gly Val Leu Ala Phe Leu Leu Val Pro 
        35                  40                  45              

Ala Val Ala Val Leu Ile Ile Ser Leu Phe Asn Trp Asn Met Leu Ser 
    50                  55                  60                  

Pro Pro Lys Phe Val Gly Leu Arg Asn Tyr Leu Asp Ile Phe Gln Asp 
65                  70                  75                  80  

Pro Leu Ala Leu His Ser Met Leu Val Thr Val Tyr Tyr Val Leu Leu 
                85                  90                  95      

Asn Ile Pro Val Gln Thr Val Leu Ala Ile Leu Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Arg Arg Leu Pro Gly Met Gly Met Phe Arg Ala Phe Phe Val Leu 
        115                 120                 125             

Pro Trp Leu Ala Met Pro Val Ala Ile Ser Val Val Trp Asn Leu Ile 
    130                 135                 140                 

Phe Asp Pro Thr Asn Gly Val Leu Asn Asp Val Leu Thr Ala Val Gly 
145                 150                 155                 160 

Leu His Pro Gln Gln Trp Leu Ser Ser Pro Val Glu Ala Leu Pro Cys 
                165                 170                 175     

Val Ala Ala Val Asn Ile Trp Gln Trp Thr Gly Tyr Asn Met Leu Phe 
            180                 185                 190         

Phe Leu Ala Gly Leu Asn Ser Ile Pro Ser His Leu Tyr Glu Ala Ala 
        195                 200                 205             

Asn Ile Asp Gly Ala Gly Arg Leu Arg Lys Phe Phe Ser Ile Thr Leu 
    210                 215                 220                 

Pro Leu Leu Arg Pro Thr Leu Leu Phe Val Leu Ile Thr Ser Val Ile 
225                 230                 235                 240 

Gly Ser Phe Gln Val Phe Asp Thr Val Tyr Val Met Thr Gln Gly Gly 
                245                 250                 255     

Pro Gly Thr Ala Thr Asn Val Tyr Asn Tyr Tyr Ile Phe Gln Gln Gly 
            260                 265                 270         

Phe Gln Phe Phe His Met Gly Tyr Ala Ala Ala Leu Ser Val Ile Leu 
        275                 280                 285             

Phe Val Val Ile Leu Leu Val Thr Leu Ile Gln Phe Arg Phe Val Gly 
    290                 295                 300                 

Lys Gly Ala Thr Tyr Asp Met Ser 
305                 310         

<210>   434
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   434
Met Arg Ile Met Gly Ile Asp Ala Ser Ala Arg Leu Thr Arg Gln Val 
                5                   10                  15      

Glu Thr Asn Ala Ser Tyr Asn Ile Gly Arg Arg Leu Ala Pro Tyr Ala 
            20                  25                  30          

Phe Ile Phe Pro Ser Phe Ile Gly Val Leu Ala Phe Leu Leu Val Pro 
        35                  40                  45              

Ala Val Ala Val Leu Ile Ile Ser Leu Phe Asn Trp Asn Met Leu Ser 
    50                  55                  60                  

Pro Pro Lys Phe Val Gly Leu Arg Asn Tyr Leu Asp Ile Phe Gln Asp 
65                  70                  75                  80  

Pro Leu Ala Leu His Ser Met Leu Val Thr Val Tyr Tyr Val Leu Leu 
                85                  90                  95      

Asn Ile Pro Val Gln Thr Val Leu Ala Ile Leu Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Arg Arg Leu Pro Gly Met Gly Met Phe Arg Ala Phe Phe Val Leu 
        115                 120                 125             

Pro Trp Leu Ala Met Pro Val Ala Ile Ser Val Val Trp Asn Leu Ile 
    130                 135                 140                 

Phe Asp Pro Thr Asn Gly Val Leu Asn Asp Val Leu Thr Ala Val Gly 
145                 150                 155                 160 

Leu His Pro Gln Gln Trp Leu Ser Ser Pro Val Glu Ala Ile Pro Cys 
                165                 170                 175     

Val Ala Ala Val Asn Ile Trp Gln Trp Thr Gly Tyr Asn Met Leu Phe 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Ile Pro Ser His Leu Tyr Glu Ala Ala 
        195                 200                 205             

Asn Ile Asp Gly Ala Gly Arg Leu Arg Lys Phe Phe Ser Ile Thr Leu 
    210                 215                 220                 

Pro Leu Leu Arg Pro Thr Leu Leu Phe Val Leu Ile Thr Ser Val Ile 
225                 230                 235                 240 

Gly Ser Phe Gln Val Phe Asp Thr Val Tyr Val Met Thr Gln Gly Gly 
                245                 250                 255     

Pro Gly Thr Ala Thr Asn Val Tyr Asn Tyr Tyr Ile Phe Gln Gln Gly 
            260                 265                 270         

Phe Gln Phe Phe His Met Gly Tyr Ala Ala Ala Leu Ser Val Ile Leu 
        275                 280                 285             

Phe Val Val Ile Leu Leu Val Thr Leu Ile Gln Phe Arg Phe Val Gly 
    290                 295                 300                 

Lys Gly Ala Thr Tyr Asp Met Ser 
305                 310         

<210>   435
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   435
Met Arg Ile Met Gly Ile Asp Ala Ser Ala Arg Leu Thr Arg Gln Val 
                5                   10                  15      

Glu Thr Asn Ala Ser Tyr Asn Ile Gly Arg Arg Leu Ala Pro Tyr Ala 
            20                  25                  30          

Phe Ile Phe Pro Ser Phe Ile Gly Val Leu Ala Phe Leu Leu Val Pro 
        35                  40                  45              

Ala Val Ala Val Leu Leu Ile Ser Leu Phe Asn Trp Asn Met Leu Ser 
    50                  55                  60                  

Pro Pro Lys Phe Val Gly Leu Arg Asn Tyr Leu Asp Ile Phe Gln Asp 
65                  70                  75                  80  

Pro Leu Ala Leu His Ser Met Leu Val Thr Val Tyr Tyr Val Leu Leu 
                85                  90                  95      

Asn Ile Pro Val Gln Thr Val Leu Ala Ile Leu Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Arg Arg Leu Pro Gly Met Gly Met Phe Arg Ala Phe Phe Val Leu 
        115                 120                 125             

Pro Trp Leu Ala Met Pro Val Ala Ile Ser Val Val Trp Asn Leu Ile 
    130                 135                 140                 

Phe Asp Pro Thr Asn Gly Val Leu Asn Asp Val Leu Thr Ala Val Gly 
145                 150                 155                 160 

Leu His Pro Gln Gln Trp Leu Ser Ser Pro Val Glu Ala Leu Pro Cys 
                165                 170                 175     

Val Ala Ala Val Asn Ile Trp Gln Trp Thr Gly Tyr Asn Met Leu Phe 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Ile Pro Ser His Leu Tyr Glu Ala Ala 
        195                 200                 205             

Asn Ile Asp Gly Ala Gly Arg Leu Arg Lys Phe Phe Ser Ile Thr Leu 
    210                 215                 220                 

Pro Leu Leu Arg Pro Thr Leu Leu Phe Val Leu Ile Thr Ser Val Ile 
225                 230                 235                 240 

Gly Ser Phe Gln Val Phe Asp Thr Val Tyr Val Met Thr Gln Gly Gly 
                245                 250                 255     

Pro Gly Thr Ala Thr Asn Val Tyr Asn Tyr Tyr Ile Phe Gln Gln Gly 
            260                 265                 270         

Phe Gln Phe Phe His Met Gly Tyr Ala Ala Ala Leu Ser Val Ile Leu 
        275                 280                 285             

Phe Val Val Ile Leu Leu Val Thr Leu Ile Gln Phe Arg Phe Val Gly 
    290                 295                 300                 

Lys Gly Ala Thr Tyr Asp Met Ser 
305                 310         

<210>   436
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   436
Met Arg Ile Met Gly Ile Asp Ala Ser Ala Arg Leu Thr Arg Gln Val 
                5                   10                  15      

Glu Thr Asn Ala Ser Tyr Asn Ile Gly Arg Arg Leu Ala Pro Tyr Ala 
            20                  25                  30          

Phe Ile Phe Pro Ser Phe Ile Gly Val Leu Ala Phe Leu Leu Val Pro 
        35                  40                  45              

Ala Val Ala Val Leu Ile Ile Ser Leu Phe Asn Trp Asn Met Leu Ser 
    50                  55                  60                  

Pro Pro Lys Phe Val Gly Leu Arg Asn Tyr Leu Asp Ile Phe Gln Asp 
65                  70                  75                  80  

Pro Leu Ala Leu His Ser Met Leu Val Thr Val Tyr Tyr Val Leu Leu 
                85                  90                  95      

Asn Ile Pro Val Gln Thr Val Leu Ala Ile Leu Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Arg Arg Leu Pro Gly Met Gly Met Phe Arg Ala Phe Phe Val Leu 
        115                 120                 125             

Pro Trp Leu Ala Met Pro Val Ala Ile Ser Val Val Trp Asn Leu Ile 
    130                 135                 140                 

Phe Asp Pro Thr Asn Gly Val Leu Asn Asp Val Leu Thr Ala Val Gly 
145                 150                 155                 160 

Leu His Pro Gln Gln Trp Leu Ser Ser Pro Val Glu Ala Leu Pro Cys 
                165                 170                 175     

Val Ala Ala Val Asn Ile Trp Gln Trp Thr Gly Tyr Asn Met Leu Phe 
            180                 185                 190         

Phe Ile Ala Gly Leu Gln Ser Ile Pro Ser His Leu Tyr Glu Ala Ala 
        195                 200                 205             

Asn Ile Asp Gly Ala Gly Arg Leu Arg Lys Phe Phe Ser Ile Thr Leu 
    210                 215                 220                 

Pro Leu Leu Arg Pro Thr Leu Leu Phe Val Leu Ile Thr Ser Val Ile 
225                 230                 235                 240 

Gly Ser Phe Gln Val Phe Asp Thr Val Tyr Val Met Thr Gln Gly Gly 
                245                 250                 255     

Pro Gly Thr Ala Thr Asn Val Tyr Asn Tyr Tyr Ile Phe Gln Gln Gly 
            260                 265                 270         

Phe Gln Phe Phe His Met Gly Tyr Ala Ala Ala Leu Ser Val Ile Leu 
        275                 280                 285             

Phe Val Val Ile Leu Leu Val Thr Leu Ile Gln Phe Arg Phe Val Gly 
    290                 295                 300                 

Lys Gly Ala Thr Tyr Asp Met Ser 
305                 310         

<210>   437
<211>   312
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 426

<400>   437
Met Arg Ile Met Gly Ile Asp Ala Ser Ala Arg Leu Thr Arg Gln Val 
                5                   10                  15      

Glu Thr Asn Ala Ser Tyr Asn Ile Gly Arg Arg Leu Ala Pro Tyr Ala 
            20                  25                  30          

Phe Ile Phe Pro Ser Phe Ile Gly Val Leu Ala Phe Leu Leu Val Pro 
        35                  40                  45              

Ala Val Ala Val Leu Ile Ile Ser Leu Phe Asn Trp Asn Met Ile Ser 
    50                  55                  60                  

Pro Pro Lys Phe Val Gly Leu Arg Asn Tyr Leu Asp Ile Phe Gln Asp 
65                  70                  75                  80  

Pro Leu Ala Leu His Ser Met Leu Val Thr Val Tyr Tyr Val Leu Leu 
                85                  90                  95      

Asn Ile Pro Val Gln Thr Val Leu Ala Ile Leu Leu Ala Leu Leu Leu 
            100                 105                 110         

Asn Arg Arg Leu Pro Gly Met Gly Met Phe Arg Ala Phe Phe Val Leu 
        115                 120                 125             

Pro Trp Leu Ala Met Pro Val Ala Ile Ser Val Val Trp Asn Leu Ile 
    130                 135                 140                 

Phe Asp Pro Thr Asn Gly Val Leu Asn Asp Val Leu Thr Ala Val Gly 
145                 150                 155                 160 

Leu His Pro Gln Gln Trp Leu Ser Ser Pro Val Glu Ala Leu Pro Cys 
                165                 170                 175     

Val Ala Ala Val Asn Ile Trp Gln Trp Thr Gly Tyr Asn Met Leu Phe 
            180                 185                 190         

Phe Leu Ala Gly Leu Gln Ser Ile Pro Ser His Leu Tyr Glu Ala Ala 
        195                 200                 205             

Asn Ile Asp Gly Ala Gly Arg Leu Arg Lys Phe Phe Ser Ile Thr Leu 
    210                 215                 220                 

Pro Leu Leu Arg Pro Thr Leu Leu Phe Val Leu Ile Thr Ser Val Ile 
225                 230                 235                 240 

Gly Ser Phe Gln Val Phe Asp Thr Val Tyr Val Met Thr Gln Gly Gly 
                245                 250                 255     

Pro Gly Thr Ala Thr Asn Val Tyr Asn Tyr Tyr Ile Phe Gln Gln Gly 
            260                 265                 270         

Phe Gln Phe Phe His Met Gly Tyr Ala Ala Ala Leu Ser Val Ile Leu 
        275                 280                 285             

Phe Val Val Ile Leu Leu Val Thr Leu Ile Gln Phe Arg Phe Val Gly 
    290                 295                 300                 

Lys Gly Ala Thr Tyr Asp Met Ser 
305                 310         

<210>   438
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   438
gtgagaatta tggggatcga cgccagcgct cggctgactc ggcaagtaga aacaaatgct       60

tcatacaaca tcggcaggcg actggctcct tacgccttta tattcccgag tttcatagga      120

gtattggcgt ttcttcttgt acctgctgtc gcagtgctga ttataagcct cttcaattgg      180

aatatgttat caccccctaa atttgttggg cttcgtaact atcttgacat ctttcaagat      240

ccccttgcac tccactccat gcttgtgaca gtgtattatg ttttgctcaa tattccggtc      300

caaactgtgt tggccatttt gcttgcgctt ttgttgaacc gcagacttcc gggaatgggg      360

atgtttcgag cgttctttgt ccttccttgg ctggccatgc cggtagctat ctcagtggtg      420

tggaacttga tctttgatcc aaccaatggc gttctcaatg acgtgttaac tgccgttggc      480

ctgcacccgc agcagtggct ttcatcgcca gtagaagccc tgccttgcgt tgctgcagta      540

aacatatggc aatggaccgg gtataacatg ctctttttcc ttgcggggct aaatagtatc      600

ccgtcccatc tttatgaagc agcgaatatc gatggggcgg ggcgactgcg aaagttcttt      660

tcaatcacct tgccactgct caggccgaca ctgttgttcg tgctgatcac gagtgtgatc      720

ggctcctttc aagtgttcga cactgtctat gtgatgacac aaggaggtcc cggtacagcg      780

acgaacgttt acaactacta tatattccag cagggatttc agttttttca catgggctat      840

gctgcggcgt tgtcagtcat tctgtttgtc gtgattctct tggttacact tatccaattc      900

cgttttgtgg gcaaaggagc aacatacgac atgagttga                             939


<210>   439
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   439
gtgagaatta tggggatcga cgccagcgct cggctgactc ggcaagtaga aacaaatgct       60

tcatacaaca tcggcaggcg actggctcct tacgccttta tattcccgag tttcatagga      120

gtattggcgt ttcttcttgt acctgctgtc gcagtgctga ttataagcct cttcaattgg      180

aatatgttat caccccctaa atttgttggg cttcgtaact atcttgacat ctttcaagat      240

ccccttgcac tccactccat gcttgtgaca gtgtattatg ttttgctcaa tattccggtc      300

caaactgtgt tggccatttt gcttgcgctt ttgttgaacc gcagacttcc gggaatgggg      360

atgtttcgag cgttctttgt ccttccttgg ctggccatgc cggtagctat ctcagtggtg      420

tggaacttga tctttgatcc aaccaatggc gttctcaatg acgtgttaac tgccgttggc      480

ctgcacccgc agcagtggct ttcatcgcca gtagaagcca ttccttgcgt tgctgcagta      540

aacatatggc aatggaccgg gtataacatg ctctttttcc ttgcggggct acaaagtatc      600

ccgtcccatc tttatgaagc agcgaatatc gatggggcgg ggcgactgcg aaagttcttt      660

tcaatcacct tgccactgct caggccgaca ctgttgttcg tgctgatcac gagtgtgatc      720

ggctcctttc aagtgttcga cactgtctat gtgatgacac aaggaggtcc cggtacagcg      780

acgaacgttt acaactacta tatattccag cagggatttc agttttttca catgggctat      840

gctgcggcgt tgtcagtcat tctgtttgtc gtgattctct tggttacact tatccaattc      900

cgttttgtgg gcaaaggagc aacatacgac atgagttga                             939


<210>   440
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   440
gtgagaatta tggggatcga cgccagcgct cggctgactc ggcaagtaga aacaaatgct       60

tcatacaaca tcggcaggcg actggctcct tacgccttta tattcccgag tttcatagga      120

gtattggcgt ttcttcttgt acctgctgtc gcagtgctgt taataagcct cttcaattgg      180

aatatgttat caccccctaa atttgttggg cttcgtaact atcttgacat ctttcaagat      240

ccccttgcac tccactccat gcttgtgaca gtgtattatg ttttgctcaa tattccggtc      300

caaactgtgt tggccatttt gcttgcgctt ttgttgaacc gcagacttcc gggaatgggg      360

atgtttcgag cgttctttgt ccttccttgg ctggccatgc cggtagctat ctcagtggtg      420

tggaacttga tctttgatcc aaccaatggc gttctcaatg acgtgttaac tgccgttggc      480

ctgcacccgc agcagtggct ttcatcgcca gtagaagccc tgccttgcgt tgctgcagta      540

aacatatggc aatggaccgg gtataacatg ctctttttcc ttgcggggct acaaagtatc      600

ccgtcccatc tttatgaagc agcgaatatc gatggggcgg ggcgactgcg aaagttcttt      660

tcaatcacct tgccactgct caggccgaca ctgttgttcg tgctgatcac gagtgtgatc      720

ggctcctttc aagtgttcga cactgtctat gtgatgacac aaggaggtcc cggtacagcg      780

acgaacgttt acaactacta tatattccag cagggatttc agttttttca catgggctat      840

gctgcggcgt tgtcagtcat tctgtttgtc gtgattctct tggttacact tatccaattc      900

cgttttgtgg gcaaaggagc aacatacgac atgagttga                             939


<210>   441
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   441
gtgagaatta tggggatcga cgccagcgct cggctgactc ggcaagtaga aacaaatgct       60

tcatacaaca tcggcaggcg actggctcct tacgccttta tattcccgag tttcatagga      120

gtattggcgt ttcttcttgt acctgctgtc gcagtgctga ttataagcct cttcaattgg      180

aatatgttat caccccctaa atttgttggg cttcgtaact atcttgacat ctttcaagat      240

ccccttgcac tccactccat gcttgtgaca gtgtattatg ttttgctcaa tattccggtc      300

caaactgtgt tggccatttt gcttgcgctt ttgttgaacc gcagacttcc gggaatgggg      360

atgtttcgag cgttctttgt ccttccttgg ctggccatgc cggtagctat ctcagtggtg      420

tggaacttga tctttgatcc aaccaatggc gttctcaatg acgtgttaac tgccgttggc      480

ctgcacccgc agcagtggct ttcatcgcca gtagaagccc tgccttgcgt tgctgcagta      540

aacatatggc aatggaccgg gtataacatg ctctttttca ttgcggggct acaaagtatc      600

ccgtcccatc tttatgaagc agcgaatatc gatggggcgg ggcgactgcg aaagttcttt      660

tcaatcacct tgccactgct caggccgaca ctgttgttcg tgctgatcac gagtgtgatc      720

ggctcctttc aagtgttcga cactgtctat gtgatgacac aaggaggtcc cggtacagcg      780

acgaacgttt acaactacta tatattccag cagggatttc agttttttca catgggctat      840

gctgcggcgt tgtcagtcat tctgtttgtc gtgattctct tggttacact tatccaattc      900

cgttttgtgg gcaaaggagc aacatacgac atgagttga                             939


<210>   442
<211>   939
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 427

<400>   442
gtgagaatta tggggatcga cgccagcgct cggctgactc ggcaagtaga aacaaatgct       60

tcatacaaca tcggcaggcg actggctcct tacgccttta tattcccgag tttcatagga      120

gtattggcgt ttcttcttgt acctgctgtc gcagtgctga ttataagcct cttcaattgg      180

aatatgattt caccccctaa atttgttggg cttcgtaact atcttgacat ctttcaagat      240

ccccttgcac tccactccat gcttgtgaca gtgtattatg ttttgctcaa tattccggtc      300

caaactgtgt tggccatttt gcttgcgctt ttgttgaacc gcagacttcc gggaatgggg      360

atgtttcgag cgttctttgt ccttccttgg ctggccatgc cggtagctat ctcagtggtg      420

tggaacttga tctttgatcc aaccaatggc gttctcaatg acgtgttaac tgccgttggc      480

ctgcacccgc agcagtggct ttcatcgcca gtagaagccc tgccttgcgt tgctgcagta      540

aacatatggc aatggaccgg gtataacatg ctctttttcc ttgcggggct acaaagtatc      600

ccgtcccatc tttatgaagc agcgaatatc gatggggcgg ggcgactgcg aaagttcttt      660

tcaatcacct tgccactgct caggccgaca ctgttgttcg tgctgatcac gagtgtgatc      720

ggctcctttc aagtgttcga cactgtctat gtgatgacac aaggaggtcc cggtacagcg      780

acgaacgttt acaactacta tatattccag cagggatttc agttttttca catgggctat      840

gctgcggcgt tgtcagtcat tctgtttgtc gtgattctct tggttacact tatccaattc      900

cgttttgtgg gcaaaggagc aacatacgac atgagttga                             939


<210>   443
<211>   459
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   443
Met Thr Arg Ser His Ser Arg Gln Ala Val Gly Val Thr Glu Arg Asp 
                5                   10                  15      

Gly Gly Arg Phe Ala Leu Leu Val Glu Ala Pro Pro Ala Ala Ala Pro 
            20                  25                  30          

Gln Thr Arg Ser Trp Ala Asp Thr Pro Leu Gly Phe Gly Gly Gly Arg 
        35                  40                  45              

Pro Pro Trp Gln Arg Val Leu Gly Glu Val Arg Pro His Pro Arg Ala 
    50                  55                  60                  

Pro Leu Arg Ala Arg Thr Pro Val Gly Pro Met Gly Gln Val Val Arg 
65                  70                  75                  80  

Ala Thr Asn Ala Arg Asn Pro Cys Ser Leu Leu Arg Ser Gln Asn Val 
                85                  90                  95      

Phe Gly Tyr Ile Asp Ala Asp Ser Arg Val Val Gly Ser Gly Cys Arg 
            100                 105                 110         

Lys Arg Phe Gly Cys Ala Gly Gly Ser Gln Lys Gly Phe Ala Ala Met 
        115                 120                 125             

Arg Val Thr Ile Arg Asp Val Ala Arg Ala Ala Gly Val Ser Val Thr 
    130                 135                 140                 

Thr Val Ser Arg Ala Leu Asn Gly Ala Ala Asp Val Gly Glu Glu Thr 
145                 150                 155                 160 

Arg Gln Arg Val Ile Glu Val Ala Lys Gln Leu Asn Tyr Arg Pro Ser 
                165                 170                 175     

His Val Ala Arg Ser Leu Val Leu Arg Lys Ser Gln Asn Ile Gly Leu 
            180                 185                 190         

Leu Val Ser Asp Phe Arg Lys Gly Ser His His Phe Leu Tyr Asp Val 
        195                 200                 205             

Leu Val Gly Val His Asp Thr Leu Ala Glu Tyr Gly Tyr Asp Val Thr 
    210                 215                 220                 

Leu Val Ser Thr Asp Thr Ala Arg Gln Gln Leu Val Ser Tyr Val Asp 
225                 230                 235                 240 

Phe Cys Arg Ala Arg Gly Leu Asp Gly Val Ile Val Met Gly Ile Arg 
                245                 250                 255     

Leu Asp Asp Pro Tyr Val Glu Glu Val Val Glu Ser Thr Leu Pro Ser 
            260                 265                 270         

Val Val Ile Asp Leu Pro Leu Leu Ser Arg His Cys Gly Tyr Val Met 
        275                 280                 285             

Thr Asp Asn Val Asn Gly Ala Arg Tyr Ala Val Arg His Leu Val Ser 
    290                 295                 300                 

Arg Gly Cys Arg Arg Ile Gly Phe Val Asn Gly Ala Ala His Ala Ala 
305                 310                 315                 320 

Val Ser Arg Glu Arg Leu Arg Gly Phe Glu Asp Ala Val Arg Gln Tyr 
                325                 330                 335     

Val Gly Gly Phe Asp Glu Arg Leu Val Val Tyr Gly Asp Phe Thr Leu 
            340                 345                 350         

Glu Gly Gly Gln Arg Ala Leu Ala Glu Leu Leu Ala Lys Ala Pro Asp 
        355                 360                 365             

Val Asp Gly Val Phe Phe Ala Ser Asp Leu Met Ala Ile Gly Gly Ile 
    370                 375                 380                 

Gln His Cys Lys Ala Met Gly Ile Arg Ile Pro Asp Asp Leu Ala Val 
385                 390                 395                 400 

Val Gly Phe Asp Asp Ile Asp Leu Ala Arg Phe Val Thr Pro Ala Leu 
                405                 410                 415     

Thr Thr Val Ala Gln Pro Arg Tyr Glu Met Gly Cys Glu Ala Ala Lys 
            420                 425                 430         

Met Leu Val His Met Leu Gln Lys Gly Glu Met Pro Ser Gly Thr Leu 
        435                 440                 445             

Leu Pro Pro Gln Leu Val Val Arg Glu Thr Ala 
    450                 455                 

<210>   444
<211>   1380
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   444
gtgacgcgct cgcattcgcg tcaggcggtt ggggtcaccg agcgcgacgg tgggaggttt       60

gcgcttctag ttgaagcgcc tcccgccgca gcgcctcaaa cgcggagttg ggcggatacg      120

ccgcttggct ttggcggagg ccggccgcca tggcagcgag tgcttggcga ggttcgcccg      180

catccacgtg cgcctctgcg agcccgtacc cctgtcggcc cgatgggaca ggttgtacga      240

gccacaaacg cacggaatcc atgttccctc ttgcgttccc aaaacgtttt cgggtatatt      300

gatgctgact cgcgtgtggt aggttcgggt tgccgaaaac gttttggatg cgccggaggc      360

tcgcaaaagg ggtttgccgc catgagagtc accattcgcg acgtggcgcg cgcagcaggc      420

gtttccgtca cgacggtgtc gagggcgctg aatggcgccg cggacgtcgg tgaagagacg      480

cgccagcgcg tcattgaggt cgccaagcaa ctgaactatc gcccgagcca cgtggcgcgg      540

agcctcgtgc tcaggaagag ccagaacatc gggcttttgg tgtccgattt tcgcaaaggc      600

agccaccact ttctctacga cgttttggtc ggcgtacacg acacgcttgc cgagtacggg      660

tacgatgtca cgctggtcag cacggacacc gcccgccagc aactggtgag ctacgtggac      720

ttttgccggg cgcgagggct ggacggcgtg atcgtcatgg gcattcgcct ggacgatccg      780

tacgtcgagg aggtcgtgga gtccacgctg ccgagcgtcg tgatcgatct gccgctgctc      840

agccggcact gcggttacgt gatgacggac aacgtgaacg gcgcgcgcta cgcggtgagg      900

cacctcgtat cccgggggtg caggcgcatc ggttttgtga acggcgccgc gcacgctgcg      960

gtgagccgcg agcggctgag gggattcgag gacgccgtgc gccaatatgt gggggggttc     1020

gacgagcgcc tcgtggtcta tggggatttc acgctcgaag ggggacagcg cgcgctcgcc     1080

gagctgctcg ccaaagcgcc ggacgtggat ggcgtgttct tcgcgagcga tctcatggcc     1140

atcggaggca tccaacactg caaggcgatg ggcatccgca ttccggacga tctcgcggtg     1200

gtcggatttg acgatatcga cctcgcgcgt ttcgtgacgc ccgcgctgac gacggtcgca     1260

cagccgcggt atgagatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcagaag     1320

ggcgagatgc catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga     1380

                                                                      1380


<210>   445
<211>   330
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   445
Thr Ile Lys Asp Ile Ala Lys Ala Ala Gly Val Ser Val Thr Thr Val 
                5                   10                  15      

Ser Arg Ala Leu Asn Gly Tyr Ser Asp Val Asn Glu Lys Thr Arg Glu 
            20                  25                  30          

Lys Ile Met Ser Val Ala Lys Glu Leu Asn Tyr Ser Pro Asn Thr Leu 
        35                  40                  45              

Ala Arg Ser Leu Val Met Asn Lys Ser Lys Thr Ile Gly Leu Leu Val 
    50                  55                  60                  

Ser Gly Leu Asn Lys Gly Ser Val Lys Asp Asn Phe Thr Phe Glu Val 
65                  70                  75                  80  

Leu Ser Gly Val Asn Asp Tyr Val Ser Glu Thr Asp Tyr Asp Leu Val 
                85                  90                  95      

Leu Phe Ser Thr Thr Ser Ile Lys Gln Arg Glu Lys Thr Tyr Thr Gln 
            100                 105                 110         

Leu Cys Arg Glu Arg Arg Val Asp Gly Val Ile Met Gln Gly Ile Arg 
        115                 120                 125             

Thr Asp Asp Pro Tyr Leu Gln Glu Val Val Glu Ser Asp Ile Pro Cys 
    130                 135                 140                 

Val Leu Ile Asp Ile Pro Ile Glu Thr Asp Thr Ala Gly Tyr Ile Thr 
145                 150                 155                 160 

Thr Asp Asn Lys Leu Gly Ala Lys Lys Ala Ile Glu His Leu Ile Arg 
                165                 170                 175     

Leu Gly His Arg Asn Ile Ala Met Ile Asn Gly His Glu Tyr Ala Phe 
            180                 185                 190         

Val Ser Gln Gln Arg Leu Gln Gly Phe Glu Glu Ala Met Gln Gly Ala 
        195                 200                 205             

Gly Leu Ser Leu Asn Lys Glu Trp Ile Val Asn Gly Glu Phe Asn Glu 
    210                 215                 220                 

Glu Ala Ala Glu Ser Ala Ala Val Lys Leu Leu Lys Glu His His Glu 
225                 230                 235                 240 

Ile Ser Ala Ile Phe Cys Ala Ser Asp Leu Met Ala Leu Gly Val Met 
                245                 250                 255     

Lys Ala Ala Lys Arg Leu Asn Leu Gln Val Pro Glu Glu Leu Ser Val 
            260                 265                 270         

Val Gly Tyr Asp Asp Ile Met Leu Ser Ser Tyr Val Ser Pro Pro Leu 
        275                 280                 285             

Thr Thr Ile Ala Gln Asn Lys Phe Leu Met Gly Tyr Glu Ala Ala Lys 
    290                 295                 300                 

Met Leu Ile Asn Thr Leu Glu Glu Lys Glu Glu Pro His Val Val Thr 
305                 310                 315                 320 

Leu Asp Thr Glu Leu Lys Ile Arg Glu Thr 
                325                 330 

<210>   446
<211>   333
<212>   PRT
<213>   Thermoanaerobacter pseudethanolicus ATCC 33223

<400>   446
Met Ala Val Thr Ile Lys Asp Ile Ala Lys Tyr Ala Gly Val Ser Val 
                5                   10                  15      

Thr Thr Val Ser Arg Ala Leu Asn Gly Tyr Pro Asp Val Ser Glu Glu 
            20                  25                  30          

Thr Arg Glu Arg Ile Lys Lys Ile Ala Glu Gln Leu Asn Tyr Thr Pro 
        35                  40                  45              

Asn Ser Ile Ala Arg Gly Leu Val Thr Asn Lys Thr His Thr Val Gly 
    50                  55                  60                  

Leu Ile Val Ser Glu Leu Ile Lys Pro Gly Ala Tyr His Pro Phe Phe 
65                  70                  75                  80  

Leu Glu Val Leu Ala Gly Ile Lys Ala Gly Leu Lys Lys Asp Lys Tyr 
                85                  90                  95      

Asp Leu Ile Leu Phe Thr Val Asp Pro Glu Ser Gln Asp Ala Thr Ser 
            100                 105                 110         

Tyr Glu Lys Leu Cys Asn Asp Arg Lys Val Glu Gly Ala Ile Val Glu 
        115                 120                 125             

Gly Leu Arg Leu Ser Asp Pro Tyr Ile Glu Glu Ile Lys Arg Thr Gln 
    130                 135                 140                 

Ile Pro Thr Val Leu Ile Asp Ile Pro Ile Leu Thr Asp Lys Val Gly 
145                 150                 155                 160 

Tyr Val Ser Ser Asp Asn Val Gln Ala Ala Phe Glu Ala Thr Ser Tyr 
                165                 170                 175     

Leu Ile Lys Leu Gly His Arg Asn Ile Gly Phe Ile Asn Gly His Gly 
            180                 185                 190         

Asp Ala Ala Val Ser Phe Glu Arg Leu Glu Gly Tyr Lys Lys Ala Leu 
        195                 200                 205             

Glu Lys Asn Asn Ile Pro Tyr Lys Glu Glu Tyr Val Val Phe Asp Asp 
    210                 215                 220                 

Phe Thr Gln Glu Gly Gly Tyr Asn Ser Phe Lys Thr Leu Val Phe Glu 
225                 230                 235                 240 

His Pro Glu Ile Thr Ala Val Phe His Ala Ser Asp Leu Met Ala Ile 
                245                 250                 255     

Gly Ser Phe Lys Ala Ala Lys Asp Leu Gly Met Lys Val Pro Asp Asp 
            260                 265                 270         

Ile Ser Ile Val Gly Phe Asp Asp Ile Glu Leu Ala Ser Leu Ile Thr 
        275                 280                 285             

Pro Gly Leu Thr Thr Ile Arg Gln Asp Thr Phe Lys Met Gly Tyr Asn 
    290                 295                 300                 

Ala Ala Lys His Leu Leu Ser Ile Ile Lys Gly Glu Lys Pro Gln His 
305                 310                 315                 320 

Ile Leu Ile Pro His Lys Leu Val Ile Arg Asp Ser Ala 
                325                 330             

<210>   447
<211>   333
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   447
Met Ala Val Thr Ile Lys Asp Ile Ala Lys Tyr Ala Gly Val Ser Val 
                5                   10                  15      

Thr Thr Val Ser Arg Ala Leu Asn Gly Tyr Pro Asp Val Ser Glu Glu 
            20                  25                  30          

Thr Arg Glu Arg Ile Lys Lys Ile Ala Glu Gln Leu Asn Tyr Thr Pro 
        35                  40                  45              

Asn Ser Ile Ala Arg Gly Leu Val Thr Asn Lys Thr His Thr Val Gly 
    50                  55                  60                  

Leu Ile Val Ser Glu Leu Ile Lys Pro Gly Ala Tyr His Pro Phe Phe 
65                  70                  75                  80  

Leu Glu Val Leu Ala Gly Ile Lys Ala Gly Leu Lys Lys Asp Lys Tyr 
                85                  90                  95      

Asp Leu Ile Leu Phe Thr Val Asp Pro Glu Ser Gln Asp Ala Thr Ser 
            100                 105                 110         

Tyr Glu Lys Leu Cys Asn Asp Arg Lys Val Glu Gly Ala Ile Val Glu 
        115                 120                 125             

Gly Leu Arg Leu Ser Asp Pro Tyr Ile Glu Glu Ile Lys Arg Thr Gln 
    130                 135                 140                 

Ile Pro Thr Val Leu Ile Asp Ile Pro Ile Leu Thr Asp Lys Val Gly 
145                 150                 155                 160 

Tyr Val Ser Ser Asp Asn Val Gln Ala Ala Phe Glu Ala Thr Ser Tyr 
                165                 170                 175     

Leu Ile Lys Leu Gly His Arg Asn Ile Gly Phe Ile Asn Gly His Asn 
            180                 185                 190         

Asp Ala Ala Val Ser Phe Glu Arg Leu Glu Gly Tyr Lys Lys Ala Leu 
        195                 200                 205             

Glu Lys Asn Asn Ile Pro Tyr Lys Glu Glu Tyr Val Val Phe Asp Asp 
    210                 215                 220                 

Phe Thr Gln Glu Gly Gly Tyr Asn Ser Phe Lys Thr Leu Val Phe Glu 
225                 230                 235                 240 

His Pro Glu Ile Thr Ala Val Phe His Ala Ser Asp Leu Met Ala Ile 
                245                 250                 255     

Gly Ser Phe Lys Ala Ala Lys Asp Leu Gly Met Lys Val Pro Asp Asp 
            260                 265                 270         

Ile Ser Ile Val Gly Phe Asp Asp Ile Glu Leu Ala Ser Leu Ile Thr 
        275                 280                 285             

Pro Gly Leu Thr Thr Ile Arg Gln Asp Thr Phe Lys Met Gly Tyr Asn 
    290                 295                 300                 

Ala Ala Lys His Leu Leu Ser Ile Ile Lys Gly Glu Lys Pro Gln His 
305                 310                 315                 320 

Ile Leu Ile Pro His Lys Leu Val Ile Arg Asp Ser Ala 
                325                 330             

<210>   448
<211>   330
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   448
Thr Ile Lys Asp Ile Ala Lys Ala Ala Gly Val Ser Ile Thr Thr Val 
                5                   10                  15      

Ser Arg Ala Leu Asn Gly Tyr Ser Asp Val Asn Glu Asn Thr Arg Gln 
            20                  25                  30          

Lys Ile Ile Asp Ile Ala Arg Gln Leu Asn Tyr Ile Pro Asn Thr Leu 
        35                  40                  45              

Ala Arg Gly Leu Val Met Asn Lys Ser Lys Thr Ile Gly Leu Leu Val 
    50                  55                  60                  

Ser Gly Leu Thr Lys Glu Ser Ala Lys Asp Asn Phe Thr Phe Glu Val 
65                  70                  75                  80  

Leu Ala Gly Val Asn Glu Tyr Val Ser Glu Val Asp Tyr Asp Met Val 
                85                  90                  95      

Leu Phe Ser Thr Thr Ser Thr Lys Gln Arg Glu Lys Thr Tyr Thr Gln 
            100                 105                 110         

Leu Cys Arg Glu Arg Arg Val Asp Gly Ala Ile Leu Gln Gly Ile Arg 
        115                 120                 125             

Thr Asp Asp Pro Tyr Leu His Glu Val Val Glu Ser Asp Ile Pro Cys 
    130                 135                 140                 

Val Leu Ile Asp Ile Pro Ile Glu Ser Arg Thr Val Gly Tyr Val Thr 
145                 150                 155                 160 

Thr Asp Asn Val Leu Gly Ala Lys Lys Ala Val Arg His Leu Ile Glu 
                165                 170                 175     

Leu Gly His Lys Arg Ile Ala Met Ile Asn Gly Tyr Glu Tyr Ala Phe 
            180                 185                 190         

Val Ser Glu Gln Arg Leu Lys Gly Phe Lys Glu Ala Leu Leu Glu Ala 
        195                 200                 205             

Gly Leu Pro Val Arg Glu Tyr Trp Ile Ala Asn Gly Ala Phe Arg Glu 
    210                 215                 220                 

Glu Ile Ala Glu Gln Glu Ala Leu Arg Leu Leu Gln His Tyr Pro Glu 
225                 230                 235                 240 

Ile Thr Ala Phe Phe Cys Ala Ser Asp Leu Met Ala Leu Gly Val Ile 
                245                 250                 255     

Lys Ala Val Lys Arg Leu Gly Lys Arg Val Pro Asp Asp Val Ala Val 
            260                 265                 270         

Ile Gly Tyr Asp Asp Ile Ile Leu Ala Ser Tyr Ser Ser Pro Ser Leu 
        275                 280                 285             

Ser Thr Ile Ala Gln Asp Lys Phe Ala Met Gly Tyr Glu Ala Ala Lys 
    290                 295                 300                 

Leu Leu Ile Ala Met Leu Glu Gly Lys Ala Asp Ser His Ile Lys Ile 
305                 310                 315                 320 

Leu Gln Thr Glu Leu Lys Ala Arg Glu Ser 
                325                 330 

<210>   449
<211>   333
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   449
Met Ala Val Thr Ile Lys Asp Ile Ala Lys Tyr Ala Gly Val Ser Val 
                5                   10                  15      

Thr Thr Val Ser Arg Ala Leu Asn Gly Tyr Pro Asp Val Ser Glu Glu 
            20                  25                  30          

Thr Arg Ala Lys Ile Lys Lys Ile Ala Glu Glu Leu Asn Tyr Thr Pro 
        35                  40                  45              

Asn Ser Ile Ala Arg Gly Leu Val Thr Asn Lys Thr Gln Thr Ile Gly 
    50                  55                  60                  

Met Val Val Ser Glu Leu Ile Lys Pro Gly Val Tyr His Pro Phe Phe 
65                  70                  75                  80  

Leu Glu Val Leu Ala Gly Ile Lys Ala Gly Leu Lys Lys Asp Arg Tyr 
                85                  90                  95      

Asp Leu Ile Leu Phe Thr Val Asp Pro Glu Ser Gln Asp Ala Thr Ser 
            100                 105                 110         

Tyr Glu Lys Leu Cys Asn Asp Arg Lys Val Glu Gly Ala Ile Val Glu 
        115                 120                 125             

Gly Leu Arg Leu Ser Asp Pro Tyr Ile Glu Glu Ile Lys Gly Thr Gln 
    130                 135                 140                 

Ile Pro Thr Val Leu Ile Asp Ile Pro Ile Leu Thr Asp Lys Val Gly 
145                 150                 155                 160 

Tyr Val Ser Ser Asp Asn Val Gln Ala Ala Phe Glu Ala Thr Ser Tyr 
                165                 170                 175     

Leu Ile Lys Leu Gly His Lys Asn Ile Gly Phe Ile Asn Gly His Lys 
            180                 185                 190         

Asp Ala Ala Val Ser Phe Glu Arg Leu Glu Gly Tyr Lys Lys Ala Leu 
        195                 200                 205             

Glu Lys Asn Asp Ile Pro Tyr Arg Glu Glu Tyr Val Ile Phe Ala Asp 
    210                 215                 220                 

Phe Thr Gln Glu Gly Gly Tyr Asn Ala Phe Lys Thr Leu Ile Phe Glu 
225                 230                 235                 240 

His Pro Glu Ile Thr Ala Ile Phe His Ala Ser Asp Leu Met Ala Met 
                245                 250                 255     

Gly Ser Tyr Arg Ala Ala Lys Asp Leu Gly Met Arg Ile Pro Glu Asp 
            260                 265                 270         

Ile Ser Leu Val Gly Phe Asp Asp Ile Glu Leu Ala Ser Leu Ile Thr 
        275                 280                 285             

Pro Ala Leu Thr Thr Ile Arg Gln Asp Thr Phe Lys Met Gly Tyr Thr 
    290                 295                 300                 

Ala Ala Lys His Leu Leu Ala Ile Ile Arg Gly Glu Lys Pro Gln His 
305                 310                 315                 320 

Ile Val Ile Pro His Lys Leu Val Val Arg Asp Ser Ala 
                325                 330             

<210>   450
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   450
Met Thr Arg Ser His Ser Arg Gln Ala Val Gly Val Thr Glu Arg Glu 
                5                   10                  15      

Gly Gly Arg Phe Ala Leu Leu Val Glu Ala Pro Pro Ala Ala Ala Pro 
            20                  25                  30          

Gln Thr Arg Ser Trp Ala Asp Thr Pro Leu Gly Phe Gly Gly Gly Arg 
        35                  40                  45              

Pro Pro Trp Gln Arg Val Leu Gly Glu Val Arg Pro His Pro Arg Ala 
    50                  55                  60                  

Pro Leu Arg Ala Arg Thr Pro Val Gly Pro Met Gly Gln Val Val Arg 
65                  70                  75                  80  

Ala Thr Asn Ala Arg Asn Pro Cys Ser Leu Leu Arg Ser Gln Asn Val 
                85                  90                  95      

Phe Gly Tyr Ile Asp Ala Asp Ser Arg Val Val Gly Ser Gly Cys Arg 
            100                 105                 110         

Lys Arg Phe Gly Cys Ala Gly Gly Ser Gln Lys Gly Phe Ala Ala Met 
        115                 120                 125             

Arg Val Thr Ile Arg Asp Val Ala Arg Ala Ala Gly Val Ser Val Thr 
    130                 135                 140                 

Thr Val Ser Arg Ala Leu Asn Gly Ala Ala Asp Val Gly Glu Glu Thr 
145                 150                 155                 160 

Arg Gln Arg Val Ile Glu Val Ala Lys Gln Leu Asn Tyr Arg Pro Ser 
                165                 170                 175     

His Val Ala Arg Ser Leu Val Leu Arg Lys Ser Gln Asn Ile Gly Leu 
            180                 185                 190         

Leu Val Ser Asp Phe Arg Lys Gly Ser His His Phe Leu Tyr Asp Val 
        195                 200                 205             

Leu Val Gly Val His Asp Thr Leu Ala Glu Tyr Gly Tyr Asp Val Thr 
    210                 215                 220                 

Leu Val Ser Thr Asp Thr Ala Arg Gln Gln Leu Val Ser Tyr Val Asp 
225                 230                 235                 240 

Phe Cys Arg Ala Arg Gly Leu Asp Gly Val Ile Val Met Gly Ile Arg 
                245                 250                 255     

Leu Asp Asp Pro Tyr Val Glu Glu Val Val Glu Ser Thr Leu Pro Ser 
            260                 265                 270         

Val Val Ile Asp Leu Pro Leu Leu Ser Arg His Cys Gly Tyr Val Met 
        275                 280                 285             

Thr Asp Asn Val Asn Gly Ala Arg Tyr Ala Val Arg His Leu Val Ser 
    290                 295                 300                 

Arg Gly Cys Arg Arg Ile Gly Phe Val Asn Gly Ala Ala His Ala Ala 
305                 310                 315                 320 

Val Ser Arg Glu Arg Leu Arg Gly Phe Glu Asp Ala Val Arg Gln Tyr 
                325                 330                 335     

Val Gly Gly Phe Asp Glu Arg Leu Val Val Tyr Gly Asp Phe Thr Leu 
            340                 345                 350         

Glu Gly Gly Gln Arg Ala Leu Ala Glu Leu Leu Ala Lys Ala Pro Asp 
        355                 360                 365             

Val Asp Gly Val Phe Phe Ala Ser Asp Leu Met Ala Ile Gly Gly Ile 
    370                 375                 380                 

Gln His Cys Lys Ala Met Gly Ile Arg Ile Pro Asp Asp Leu Ala Val 
385                 390                 395                 400 

Val Gly Phe Asp Asp Ile Asp Leu Ala Arg Phe Val Thr Pro Ala Leu 
                405                 410                 415     

Thr Thr Val Ala Gln Pro Arg Tyr Glu Met Gly Cys Glu Ala Ala Lys 
            420                 425                 430         

Met Leu Val His Met Leu Gln Lys Gly Glu Met Pro Ser Gly Thr Leu 
        435                 440                 445             

Leu Pro Pro Gln Leu Val Val Arg Glu Thr Ala 
    450                 455                 

<210>   451
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   451
Met Thr Arg Ser His Ser Arg Gln Ala Val Gly Val Thr Glu Arg Asp 
                5                   10                  15      

Gly Gly Arg Phe Ala Leu Leu Val Glu Ala Pro Pro Ala Ala Ala Pro 
            20                  25                  30          

Gln Thr Arg Ser Trp Ala Asp Thr Pro Leu Gly Phe Gly Gly Gly Arg 
        35                  40                  45              

Pro Pro Trp Gln Arg Val Leu Gly Glu Val Arg Pro His Pro Arg Ala 
    50                  55                  60                  

Pro Leu Arg Ala Arg Thr Pro Val Gly Pro Met Gly Gln Val Val Arg 
65                  70                  75                  80  

Ala Thr Asn Ala Arg Asn Pro Cys Ser Leu Leu Arg Ser Gln Asn Val 
                85                  90                  95      

Phe Gly Tyr Ile Asp Ala Asp Ser Arg Val Val Gly Ser Gly Cys Arg 
            100                 105                 110         

Lys Arg Phe Gly Cys Ala Gly Gly Ser Gln Lys Gly Phe Ala Ala Met 
        115                 120                 125             

Arg Val Thr Ile Arg Asp Val Ala Arg Ala Ala Gly Val Ser Val Thr 
    130                 135                 140                 

Thr Val Ser Arg Ala Leu Asn Gly Ala Ala Asp Val Gly Glu Glu Thr 
145                 150                 155                 160 

Arg Gln Arg Val Ile Glu Val Ala Lys Gln Leu Asn Tyr Arg Pro Ser 
                165                 170                 175     

His Val Ala Arg Ser Leu Val Leu Arg Lys Ser Gln Asn Ile Gly Leu 
            180                 185                 190         

Leu Val Ser Asp Phe Arg Lys Gly Ser His His Phe Leu Tyr Asp Val 
        195                 200                 205             

Leu Val Gly Val His Asp Thr Leu Ala Glu Tyr Gly Tyr Asp Val Thr 
    210                 215                 220                 

Leu Val Ser Thr Asp Thr Ala Arg Gln Gln Leu Val Ser Tyr Val Asp 
225                 230                 235                 240 

Phe Cys Arg Ala Arg Gly Leu Asp Gly Val Ile Val Met Gly Ile Arg 
                245                 250                 255     

Leu Asp Asp Pro Tyr Val Asp Glu Val Val Glu Ser Thr Leu Pro Ser 
            260                 265                 270         

Val Val Ile Asp Leu Pro Leu Leu Ser Arg His Cys Gly Tyr Val Met 
        275                 280                 285             

Thr Asp Asn Val Asn Gly Ala Arg Tyr Ala Val Arg His Leu Val Ser 
    290                 295                 300                 

Arg Gly Cys Arg Arg Ile Gly Phe Val Asn Gly Ala Ala His Ala Ala 
305                 310                 315                 320 

Val Ser Arg Glu Arg Leu Arg Gly Phe Glu Asp Ala Val Arg Gln Tyr 
                325                 330                 335     

Val Gly Gly Phe Asp Glu Arg Leu Val Val Tyr Gly Asp Phe Thr Leu 
            340                 345                 350         

Glu Gly Gly Gln Arg Ala Leu Ala Glu Leu Leu Ala Lys Ala Pro Asp 
        355                 360                 365             

Val Asp Gly Val Phe Phe Ala Ser Asp Leu Met Ala Ile Gly Gly Ile 
    370                 375                 380                 

Gln His Cys Lys Ala Met Gly Ile Arg Ile Pro Asp Asp Leu Ala Val 
385                 390                 395                 400 

Val Gly Phe Asp Asp Ile Asp Leu Ala Arg Phe Val Thr Pro Ala Leu 
                405                 410                 415     

Thr Thr Val Ala Gln Pro Arg Tyr Glu Met Gly Cys Glu Ala Ala Lys 
            420                 425                 430         

Met Leu Val His Met Leu Gln Lys Gly Glu Met Pro Ser Gly Thr Leu 
        435                 440                 445             

Leu Pro Pro Gln Leu Val Val Arg Glu Thr Ala 
    450                 455                 

<210>   452
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   452
Met Thr Arg Ser His Ser Arg Gln Ala Val Gly Val Thr Glu Arg Asp 
                5                   10                  15      

Gly Gly Lys Phe Ala Leu Leu Val Glu Ala Pro Pro Ala Ala Ala Pro 
            20                  25                  30          

Gln Thr Arg Ser Trp Ala Asp Thr Pro Leu Gly Phe Gly Gly Gly Arg 
        35                  40                  45              

Pro Pro Trp Gln Arg Val Leu Gly Glu Val Arg Pro His Pro Arg Ala 
    50                  55                  60                  

Pro Leu Arg Ala Arg Thr Pro Val Gly Pro Met Gly Gln Val Val Arg 
65                  70                  75                  80  

Ala Thr Asn Ala Arg Asn Pro Cys Ser Leu Leu Arg Ser Gln Asn Val 
                85                  90                  95      

Phe Gly Tyr Ile Asp Ala Asp Ser Arg Val Val Gly Ser Gly Cys Arg 
            100                 105                 110         

Lys Arg Phe Gly Cys Ala Gly Gly Ser Gln Lys Gly Phe Ala Ala Met 
        115                 120                 125             

Arg Val Thr Ile Arg Asp Val Ala Arg Ala Ala Gly Val Ser Val Thr 
    130                 135                 140                 

Thr Val Ser Arg Ala Leu Asn Gly Ala Ala Asp Val Gly Glu Glu Thr 
145                 150                 155                 160 

Arg Gln Arg Val Ile Glu Val Ala Lys Gln Leu Asn Tyr Arg Pro Ser 
                165                 170                 175     

His Val Ala Arg Ser Leu Val Leu Arg Lys Ser Gln Asn Ile Gly Leu 
            180                 185                 190         

Leu Val Ser Asp Phe Arg Lys Gly Ser His His Phe Leu Tyr Asp Val 
        195                 200                 205             

Leu Val Gly Val His Asp Thr Leu Ala Glu Tyr Gly Tyr Asp Val Thr 
    210                 215                 220                 

Leu Val Ser Thr Asp Thr Ala Arg Gln Gln Leu Val Ser Tyr Val Asp 
225                 230                 235                 240 

Phe Cys Arg Ala Arg Gly Leu Asp Gly Val Ile Val Met Gly Ile Arg 
                245                 250                 255     

Leu Asp Asp Pro Tyr Val Glu Glu Val Val Glu Ser Thr Leu Pro Ser 
            260                 265                 270         

Val Val Ile Asp Leu Pro Leu Leu Ser Arg His Cys Gly Tyr Val Met 
        275                 280                 285             

Thr Asp Asn Val Asn Gly Ala Arg Tyr Ala Val Arg His Leu Val Ser 
    290                 295                 300                 

Arg Gly Cys Arg Arg Ile Gly Phe Val Asn Gly Ala Ala His Ala Ala 
305                 310                 315                 320 

Val Ser Arg Glu Arg Leu Arg Gly Phe Glu Asp Ala Val Arg Gln Tyr 
                325                 330                 335     

Val Gly Gly Phe Asp Glu Arg Leu Val Val Tyr Gly Asp Phe Thr Leu 
            340                 345                 350         

Glu Gly Gly Gln Arg Ala Leu Ala Glu Leu Leu Ala Lys Ala Pro Asp 
        355                 360                 365             

Val Asp Gly Val Phe Phe Ala Ser Asp Leu Met Ala Ile Gly Gly Ile 
    370                 375                 380                 

Gln His Cys Lys Ala Met Gly Ile Arg Ile Pro Asp Asp Leu Ala Val 
385                 390                 395                 400 

Val Gly Phe Asp Asp Ile Asp Leu Ala Arg Phe Val Thr Pro Ala Leu 
                405                 410                 415     

Thr Thr Val Ala Gln Pro Arg Tyr Glu Met Gly Cys Glu Ala Ala Lys 
            420                 425                 430         

Met Leu Val His Met Leu Gln Lys Gly Glu Met Pro Ser Gly Thr Leu 
        435                 440                 445             

Leu Pro Pro Gln Leu Val Val Arg Glu Thr Ala 
    450                 455                 

<210>   453
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   453
Met Thr Arg Ser His Ser Arg Gln Ala Val Gly Val Thr Glu Arg Asp 
                5                   10                  15      

Gly Gly Arg Phe Ala Leu Leu Val Glu Ala Pro Pro Ala Ala Ala Pro 
            20                  25                  30          

Gln Thr Arg Ser Trp Ala Asp Thr Pro Leu Gly Phe Gly Gly Gly Arg 
        35                  40                  45              

Pro Pro Trp Gln Arg Val Leu Gly Glu Val Arg Pro His Pro Arg Ala 
    50                  55                  60                  

Pro Leu Arg Ala Arg Thr Pro Val Gly Pro Met Gly Gln Val Val Arg 
65                  70                  75                  80  

Ala Thr Asn Ala Arg Asn Pro Cys Ser Leu Leu Arg Ser Gln Asn Val 
                85                  90                  95      

Phe Gly Tyr Ile Asp Ala Asp Ser Arg Val Val Gly Ser Gly Cys Arg 
            100                 105                 110         

Lys Arg Phe Gly Cys Ala Gly Gly Ser Gln Lys Gly Phe Ala Ala Met 
        115                 120                 125             

Arg Val Thr Ile Arg Asp Val Ala Arg Ala Ala Gly Val Ser Val Thr 
    130                 135                 140                 

Thr Val Ser Arg Ala Leu Asn Gly Ala Ala Asp Val Gly Glu Glu Thr 
145                 150                 155                 160 

Arg Gln Arg Val Ile Glu Val Ala Lys Gln Leu Asn Tyr Arg Pro Ser 
                165                 170                 175     

His Val Ala Arg Ser Leu Val Leu Arg Lys Ser Gln Asn Ile Gly Leu 
            180                 185                 190         

Leu Val Ser Asp Phe Arg Lys Gly Ser His His Phe Leu Tyr Asp Val 
        195                 200                 205             

Leu Val Gly Val His Asp Thr Leu Ala Glu Tyr Gly Tyr Asp Val Thr 
    210                 215                 220                 

Leu Val Ser Thr Asp Thr Ala Arg Gln Gln Leu Val Ser Tyr Val Asp 
225                 230                 235                 240 

Phe Cys Arg Ala Arg Gly Leu Asp Gly Val Ile Val Met Gly Ile Arg 
                245                 250                 255     

Leu Asp Asp Pro Tyr Val Glu Glu Val Val Glu Ser Thr Leu Pro Ser 
            260                 265                 270         

Val Val Ile Asp Leu Pro Leu Leu Ser Arg His Cys Gly Tyr Val Met 
        275                 280                 285             

Thr Asp Asn Val Asn Gly Ala Arg Tyr Ala Val Arg His Leu Val Ser 
    290                 295                 300                 

Arg Gly Cys Arg Arg Ile Gly Phe Val Asn Gly Ala Ala His Ala Ala 
305                 310                 315                 320 

Val Ser Arg Glu Arg Leu Arg Gly Phe Glu Asp Ala Ile Arg Gln Tyr 
                325                 330                 335     

Val Gly Gly Phe Asp Glu Arg Leu Val Val Tyr Gly Asp Phe Thr Leu 
            340                 345                 350         

Glu Gly Gly Gln Arg Ala Leu Ala Glu Leu Leu Ala Lys Ala Pro Asp 
        355                 360                 365             

Val Asp Gly Val Phe Phe Ala Ser Asp Leu Met Ala Ile Gly Gly Ile 
    370                 375                 380                 

Gln His Cys Lys Ala Met Gly Ile Arg Ile Pro Asp Asp Leu Ala Val 
385                 390                 395                 400 

Val Gly Phe Asp Asp Ile Asp Leu Ala Arg Phe Val Thr Pro Ala Leu 
                405                 410                 415     

Thr Thr Val Ala Gln Pro Arg Tyr Glu Met Gly Cys Glu Ala Ala Lys 
            420                 425                 430         

Met Leu Val His Met Leu Gln Lys Gly Glu Met Pro Ser Gly Thr Leu 
        435                 440                 445             

Leu Pro Pro Gln Leu Val Val Arg Glu Thr Ala 
    450                 455                 

<210>   454
<211>   459
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 443

<400>   454
Met Thr Arg Ser His Ser Arg Gln Ala Val Gly Val Thr Glu Arg Asp 
                5                   10                  15      

Gly Gly Arg Phe Ala Leu Leu Val Glu Ala Pro Pro Ala Ala Ala Pro 
            20                  25                  30          

Gln Thr Arg Ser Trp Ala Asp Thr Pro Leu Gly Phe Gly Gly Gly Arg 
        35                  40                  45              

Pro Pro Trp Gln Arg Val Leu Gly Glu Val Arg Pro His Pro Arg Ala 
    50                  55                  60                  

Pro Leu Arg Ala Arg Thr Pro Val Gly Pro Met Gly Gln Val Val Arg 
65                  70                  75                  80  

Ala Thr Asn Ala Arg Asn Pro Cys Ser Leu Leu Arg Ser Gln Asn Val 
                85                  90                  95      

Phe Gly Tyr Ile Asp Ala Asp Ser Arg Val Val Gly Ser Gly Cys Arg 
            100                 105                 110         

Lys Arg Phe Gly Cys Ala Gly Gly Ser Gln Lys Gly Phe Ala Ala Met 
        115                 120                 125             

Arg Val Thr Ile Arg Asp Val Ala Arg Ala Ala Gly Val Ser Val Thr 
    130                 135                 140                 

Thr Val Ser Arg Ala Leu Asn Gly Ala Ala Asp Val Gly Glu Glu Thr 
145                 150                 155                 160 

Arg Gln Arg Val Ile Glu Val Ala Lys Gln Leu Asn Tyr Arg Pro Ser 
                165                 170                 175     

His Val Ala Arg Ser Leu Val Leu Arg Lys Ser Gln Asn Ile Gly Leu 
            180                 185                 190         

Leu Val Ser Asp Phe Arg Lys Gly Ser His His Phe Leu Tyr Asp Val 
        195                 200                 205             

Leu Val Gly Val His Asp Thr Leu Ala Glu Tyr Gly Tyr Asp Val Thr 
    210                 215                 220                 

Leu Val Ser Thr Glu Thr Ala Arg Gln Gln Leu Val Ser Tyr Val Asp 
225                 230                 235                 240 

Phe Cys Arg Ala Arg Gly Leu Asp Gly Val Ile Val Met Gly Ile Arg 
                245                 250                 255     

Leu Asp Asp Pro Tyr Val Glu Glu Val Val Glu Ser Thr Leu Pro Ser 
            260                 265                 270         

Val Val Ile Asp Leu Pro Leu Leu Ser Arg His Cys Gly Tyr Val Met 
        275                 280                 285             

Thr Asp Asn Val Asn Gly Ala Arg Tyr Ala Val Arg His Leu Val Ser 
    290                 295                 300                 

Arg Gly Cys Arg Arg Ile Gly Phe Val Asn Gly Ala Ala His Ala Ala 
305                 310                 315                 320 

Val Ser Arg Glu Arg Leu Arg Gly Phe Glu Asp Ala Val Arg Gln Tyr 
                325                 330                 335     

Val Gly Gly Phe Asp Glu Arg Leu Val Val Tyr Gly Asp Phe Thr Leu 
            340                 345                 350         

Glu Gly Gly Gln Arg Ala Leu Ala Glu Leu Leu Ala Lys Ala Pro Asp 
        355                 360                 365             

Val Asp Gly Val Phe Phe Ala Ser Asp Leu Met Ala Ile Gly Gly Ile 
    370                 375                 380                 

Gln His Cys Lys Ala Met Gly Ile Arg Ile Pro Asp Asp Leu Ala Val 
385                 390                 395                 400 

Val Gly Phe Asp Asp Ile Asp Leu Ala Arg Phe Val Thr Pro Ala Leu 
                405                 410                 415     

Thr Thr Val Ala Gln Pro Arg Tyr Glu Met Gly Cys Glu Ala Ala Lys 
            420                 425                 430         

Met Leu Val His Met Leu Gln Lys Gly Glu Met Pro Ser Gly Thr Leu 
        435                 440                 445             

Leu Pro Pro Gln Leu Val Val Arg Glu Thr Ala 
    450                 455                 

<210>   455
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   455
gtgacgcgct cgcattcgcg tcaggcggtt ggggtcaccg agcgcgaagg tgggaggttt       60

gcgcttctag ttgaagcgcc tcccgccgca gcgcctcaaa cgcggagttg ggcggatacg      120

ccgcttggct ttggcggagg ccggccgcca tggcagcgag tgcttggcga ggttcgcccg      180

catccacgtg cgcctctgcg agcccgtacc cctgtcggcc cgatgggaca ggttgtacga      240

gccacaaacg cacggaatcc atgttccctc ttgcgttccc aaaacgtttt cgggtatatt      300

gatgctgact cgcgtgtggt aggttcgggt tgccgaaaac gttttggatg cgccggaggc      360

tcgcaaaagg ggtttgccgc catgagagtc accattcgcg acgtggcgcg cgcagcaggc      420

gtttccgtca cgacggtgtc gagggcgctg aatggcgccg cggacgtcgg tgaagagacg      480

cgccagcgcg tcattgaggt cgccaagcaa ctgaactatc gcccgagcca cgtggcgcgg      540

agcctcgtgc tcaggaagag ccagaacatc gggcttttgg tgtccgattt tcgcaaaggc      600

agccaccact ttctctacga cgttttggtc ggcgtacacg acacgcttgc cgagtacggg      660

tacgatgtca cgctggtcag cacggacacc gcccgccagc aactggtgag ctacgtggac      720

ttttgccggg cgcgagggct ggacggcgtg atcgtcatgg gcattcgcct ggacgatccg      780

tacgtcgagg aggtcgtgga gtccacgctg ccgagcgtcg tgatcgatct gccgctgctc      840

agccggcact gcggttacgt gatgacggac aacgtgaacg gcgcgcgcta cgcggtgagg      900

cacctcgtat cccgggggtg caggcgcatc ggttttgtga acggcgccgc gcacgctgcg      960

gtgagccgcg agcggctgag gggattcgag gacgccgtgc gccaatatgt gggggggttc     1020

gacgagcgcc tcgtggtcta tggggatttc acgctcgaag ggggacagcg cgcgctcgcc     1080

gagctgctcg ccaaagcgcc ggacgtggat ggcgtgttct tcgcgagcga tctcatggcc     1140

atcggaggca tccaacactg caaggcgatg ggcatccgca ttccggacga tctcgcggtg     1200

gtcggatttg acgatatcga cctcgcgcgt ttcgtgacgc ccgcgctgac gacggtcgca     1260

cagccgcggt atgagatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcagaag     1320

ggcgagatgc catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga     1380

                                                                      1380


<210>   456
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   456
gtgacgcgct cgcattcgcg tcaggcggtt ggggtcaccg agcgcgacgg tgggaggttt       60

gcgcttctag ttgaagcgcc tcccgccgca gcgcctcaaa cgcggagttg ggcggatacg      120

ccgcttggct ttggcggagg ccggccgcca tggcagcgag tgcttggcga ggttcgcccg      180

catccacgtg cgcctctgcg agcccgtacc cctgtcggcc cgatgggaca ggttgtacga      240

gccacaaacg cacggaatcc atgttccctc ttgcgttccc aaaacgtttt cgggtatatt      300

gatgctgact cgcgtgtggt aggttcgggt tgccgaaaac gttttggatg cgccggaggc      360

tcgcaaaagg ggtttgccgc catgagagtc accattcgcg acgtggcgcg cgcagcaggc      420

gtttccgtca cgacggtgtc gagggcgctg aatggcgccg cggacgtcgg tgaagagacg      480

cgccagcgcg tcattgaggt cgccaagcaa ctgaactatc gcccgagcca cgtggcgcgg      540

agcctcgtgc tcaggaagag ccagaacatc gggcttttgg tgtccgattt tcgcaaaggc      600

agccaccact ttctctacga cgttttggtc ggcgtacacg acacgcttgc cgagtacggg      660

tacgatgtca cgctggtcag cacggacacc gcccgccagc aactggtgag ctacgtggac      720

ttttgccggg cgcgagggct ggacggcgtg atcgtcatgg gcattcgcct ggacgatccg      780

tacgtcgatg aggtcgtgga gtccacgctg ccgagcgtcg tgatcgatct gccgctgctc      840

agccggcact gcggttacgt gatgacggac aacgtgaacg gcgcgcgcta cgcggtgagg      900

cacctcgtat cccgggggtg caggcgcatc ggttttgtga acggcgccgc gcacgctgcg      960

gtgagccgcg agcggctgag gggattcgag gacgccgtgc gccaatatgt gggggggttc     1020

gacgagcgcc tcgtggtcta tggggatttc acgctcgaag ggggacagcg cgcgctcgcc     1080

gagctgctcg ccaaagcgcc ggacgtggat ggcgtgttct tcgcgagcga tctcatggcc     1140

atcggaggca tccaacactg caaggcgatg ggcatccgca ttccggacga tctcgcggtg     1200

gtcggatttg acgatatcga cctcgcgcgt ttcgtgacgc ccgcgctgac gacggtcgca     1260

cagccgcggt atgagatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcagaag     1320

ggcgagatgc catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga     1380

                                                                      1380


<210>   457
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   457
gtgacgcgct cgcattcgcg tcaggcggtt ggggtcaccg agcgcgacgg tgggaaattt       60

gcgcttctag ttgaagcgcc tcccgccgca gcgcctcaaa cgcggagttg ggcggatacg      120

ccgcttggct ttggcggagg ccggccgcca tggcagcgag tgcttggcga ggttcgcccg      180

catccacgtg cgcctctgcg agcccgtacc cctgtcggcc cgatgggaca ggttgtacga      240

gccacaaacg cacggaatcc atgttccctc ttgcgttccc aaaacgtttt cgggtatatt      300

gatgctgact cgcgtgtggt aggttcgggt tgccgaaaac gttttggatg cgccggaggc      360

tcgcaaaagg ggtttgccgc catgagagtc accattcgcg acgtggcgcg cgcagcaggc      420

gtttccgtca cgacggtgtc gagggcgctg aatggcgccg cggacgtcgg tgaagagacg      480

cgccagcgcg tcattgaggt cgccaagcaa ctgaactatc gcccgagcca cgtggcgcgg      540

agcctcgtgc tcaggaagag ccagaacatc gggcttttgg tgtccgattt tcgcaaaggc      600

agccaccact ttctctacga cgttttggtc ggcgtacacg acacgcttgc cgagtacggg      660

tacgatgtca cgctggtcag cacggacacc gcccgccagc aactggtgag ctacgtggac      720

ttttgccggg cgcgagggct ggacggcgtg atcgtcatgg gcattcgcct ggacgatccg      780

tacgtcgagg aggtcgtgga gtccacgctg ccgagcgtcg tgatcgatct gccgctgctc      840

agccggcact gcggttacgt gatgacggac aacgtgaacg gcgcgcgcta cgcggtgagg      900

cacctcgtat cccgggggtg caggcgcatc ggttttgtga acggcgccgc gcacgctgcg      960

gtgagccgcg agcggctgag gggattcgag gacgccgtgc gccaatatgt gggggggttc     1020

gacgagcgcc tcgtggtcta tggggatttc acgctcgaag ggggacagcg cgcgctcgcc     1080

gagctgctcg ccaaagcgcc ggacgtggat ggcgtgttct tcgcgagcga tctcatggcc     1140

atcggaggca tccaacactg caaggcgatg ggcatccgca ttccggacga tctcgcggtg     1200

gtcggatttg acgatatcga cctcgcgcgt ttcgtgacgc ccgcgctgac gacggtcgca     1260

cagccgcggt atgagatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcagaag     1320

ggcgagatgc catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga     1380

                                                                      1380


<210>   458
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   458
gtgacgcgct cgcattcgcg tcaggcggtt ggggtcaccg agcgcgacgg tgggaggttt       60

gcgcttctag ttgaagcgcc tcccgccgca gcgcctcaaa cgcggagttg ggcggatacg      120

ccgcttggct ttggcggagg ccggccgcca tggcagcgag tgcttggcga ggttcgcccg      180

catccacgtg cgcctctgcg agcccgtacc cctgtcggcc cgatgggaca ggttgtacga      240

gccacaaacg cacggaatcc atgttccctc ttgcgttccc aaaacgtttt cgggtatatt      300

gatgctgact cgcgtgtggt aggttcgggt tgccgaaaac gttttggatg cgccggaggc      360

tcgcaaaagg ggtttgccgc catgagagtc accattcgcg acgtggcgcg cgcagcaggc      420

gtttccgtca cgacggtgtc gagggcgctg aatggcgccg cggacgtcgg tgaagagacg      480

cgccagcgcg tcattgaggt cgccaagcaa ctgaactatc gcccgagcca cgtggcgcgg      540

agcctcgtgc tcaggaagag ccagaacatc gggcttttgg tgtccgattt tcgcaaaggc      600

agccaccact ttctctacga cgttttggtc ggcgtacacg acacgcttgc cgagtacggg      660

tacgatgtca cgctggtcag cacggacacc gcccgccagc aactggtgag ctacgtggac      720

ttttgccggg cgcgagggct ggacggcgtg atcgtcatgg gcattcgcct ggacgatccg      780

tacgtcgagg aggtcgtgga gtccacgctg ccgagcgtcg tgatcgatct gccgctgctc      840

agccggcact gcggttacgt gatgacggac aacgtgaacg gcgcgcgcta cgcggtgagg      900

cacctcgtat cccgggggtg caggcgcatc ggttttgtga acggcgccgc gcacgctgcg      960

gtgagccgcg agcggctgag gggattcgag gacgccattc gccaatatgt gggggggttc     1020

gacgagcgcc tcgtggtcta tggggatttc acgctcgaag ggggacagcg cgcgctcgcc     1080

gagctgctcg ccaaagcgcc ggacgtggat ggcgtgttct tcgcgagcga tctcatggcc     1140

atcggaggca tccaacactg caaggcgatg ggcatccgca ttccggacga tctcgcggtg     1200

gtcggatttg acgatatcga cctcgcgcgt ttcgtgacgc ccgcgctgac gacggtcgca     1260

cagccgcggt atgagatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcagaag     1320

ggcgagatgc catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga     1380

                                                                      1380


<210>   459
<211>   1380
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 444

<400>   459
gtgacgcgct cgcattcgcg tcaggcggtt ggggtcaccg agcgcgacgg tgggaggttt       60

gcgcttctag ttgaagcgcc tcccgccgca gcgcctcaaa cgcggagttg ggcggatacg      120

ccgcttggct ttggcggagg ccggccgcca tggcagcgag tgcttggcga ggttcgcccg      180

catccacgtg cgcctctgcg agcccgtacc cctgtcggcc cgatgggaca ggttgtacga      240

gccacaaacg cacggaatcc atgttccctc ttgcgttccc aaaacgtttt cgggtatatt      300

gatgctgact cgcgtgtggt aggttcgggt tgccgaaaac gttttggatg cgccggaggc      360

tcgcaaaagg ggtttgccgc catgagagtc accattcgcg acgtggcgcg cgcagcaggc      420

gtttccgtca cgacggtgtc gagggcgctg aatggcgccg cggacgtcgg tgaagagacg      480

cgccagcgcg tcattgaggt cgccaagcaa ctgaactatc gcccgagcca cgtggcgcgg      540

agcctcgtgc tcaggaagag ccagaacatc gggcttttgg tgtccgattt tcgcaaaggc      600

agccaccact ttctctacga cgttttggtc ggcgtacacg acacgcttgc cgagtacggg      660

tacgatgtca cgctggtcag cacggaaacc gcccgccagc aactggtgag ctacgtggac      720

ttttgccggg cgcgagggct ggacggcgtg atcgtcatgg gcattcgcct ggacgatccg      780

tacgtcgagg aggtcgtgga gtccacgctg ccgagcgtcg tgatcgatct gccgctgctc      840

agccggcact gcggttacgt gatgacggac aacgtgaacg gcgcgcgcta cgcggtgagg      900

cacctcgtat cccgggggtg caggcgcatc ggttttgtga acggcgccgc gcacgctgcg      960

gtgagccgcg agcggctgag gggattcgag gacgccgtgc gccaatatgt gggggggttc     1020

gacgagcgcc tcgtggtcta tggggatttc acgctcgaag ggggacagcg cgcgctcgcc     1080

gagctgctcg ccaaagcgcc ggacgtggat ggcgtgttct tcgcgagcga tctcatggcc     1140

atcggaggca tccaacactg caaggcgatg ggcatccgca ttccggacga tctcgcggtg     1200

gtcggatttg acgatatcga cctcgcgcgt ttcgtgacgc ccgcgctgac gacggtcgca     1260

cagccgcggt atgagatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcagaag     1320

ggcgagatgc catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga     1380

                                                                      1380


<210>   460
<211>   437
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   460
Met Glu Thr Ser Gly Val Lys Pro Ile Gly Trp Glu Val Glu Arg Lys 
                5                   10                  15      

Met Arg Lys Pro Phe Leu Gly Ile Ala Gly Ala Ala Val Val Ala Met 
            20                  25                  30          

Gly Ala Val Thr Ala Cys Gly Gln Ala Gln Ser Ala Pro Ser Asn Gln 
        35                  40                  45              

Ala Asn Val Gly Ser Ala Ser Ala Ala Pro Ile His Leu Thr Leu Gly 
    50                  55                  60                  

Met Trp Ala Ser Ser Pro Ala Glu Lys Gln Leu Val Glu Arg Gln Ile 
65                  70                  75                  80  

Ala Leu Phe Glu Lys Glu Asn Pro Asn Ile Lys Val Ser Ile Gln Val 
                85                  90                  95      

Ile Thr Gly Asn Tyr Leu Gln Ala Leu Gln Pro Met Leu Ala Ala His 
            100                 105                 110         

Asp Ala Pro Asp Ile Phe Tyr Val Asp Ser Ser Tyr Ala Pro Thr Leu 
        115                 120                 125             

Glu Ala Ser Gly Ala Ile Met Pro Leu Asp Ser Phe Ile Lys Gln Asp 
    130                 135                 140                 

His Val Asp Leu Ser Asp Phe Gln Lys Asn Leu Leu Asp Ala Phe Thr 
145                 150                 155                 160 

Trp Gln Gly His Ile Tyr Gly Leu Pro Lys Asp Met Asn Thr Met Ala 
                165                 170                 175     

Leu Glu Tyr Asn Pro Ala Leu Leu Ala Lys Ala Gly Ile Gln Ser Pro 
            180                 185                 190         

Pro Lys Thr Phe Ala Gln Phe Asp Gln Asp Ala Ala Lys Leu Lys Ala 
        195                 200                 205             

Lys Gly Ile Val Pro Leu Asp Met Pro Ile Asp Val Ala Arg Tyr Tyr 
    210                 215                 220                 

Pro Phe Ile Val Asp Met Gly Gly Ser Tyr Tyr Asn Lys Ala Thr Asn 
225                 230                 235                 240 

Gln Ala Thr Phe Thr Asn Lys Ala Asn Val Ala Gly Leu Thr Trp Phe 
                245                 250                 255     

Met Lys Glu Met Glu Ser Gly Asn Phe Val Thr Pro Gln Asp Gln Gly 
            260                 265                 270         

Gly Ser Trp Ala Gly Val Pro Phe Ala Glu Gly Lys Ala Ala Met Ala 
        275                 280                 285             

Leu Glu Gly Ala Trp Ile Val Pro Phe Met Gln Gln Thr Ala Pro Lys 
    290                 295                 300                 

Met Lys Tyr Gly Ile Ala Asp Phe Pro Ser Leu Asn Gly His Asp Ala 
305                 310                 315                 320 

Asn Met Leu Phe Thr Val Ala Tyr Glu Met Ser Lys Tyr Ala Lys Asn 
                325                 330                 335     

Pro Asp Ala Ala Ala Lys Leu Leu Phe Phe Met Thr Gly Lys Glu Ala 
            340                 345                 350         

Leu Lys Met Thr Ala Asp Ser Gly Leu Ala Ile Pro Ser Arg Thr Ser 
        355                 360                 365             

Glu Gln Gly Glu Phe Leu Lys Lys Tyr Pro Ser Tyr Lys Gly Phe Val 
    370                 375                 380                 

Asp Gly Leu Lys Gly Ala Ile Pro Tyr Gln Phe Gly Thr Leu Gly Gln 
385                 390                 395                 400 

Asn Phe Leu Asp Ala Ile Asn Asn Ala Thr Gln Gln Gly Ile Leu Lys 
                405                 410                 415     

Lys Glu Ser Ala Gln Gln Val Leu Ser Gln Ala Gln Gln Thr Leu Ala 
            420                 425                 430         

Ser Gln Met Asn Asp 
        435         

<210>   461
<211>   1314
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   461
atggagacaa gcggggtcaa accgattggg tgggaggtcg aacgaaagat gaggaaacca       60

tttcttggga tcgcgggtgc ggcagtggtc gcgatgggcg cggtgacggc atgcggccag      120

gcgcagagcg cgccctccaa ccaggcgaac gtcggcagcg cgtcggcggc gcccattcat      180

ctgacgcttg gcatgtgggc gtcgagcccg gcggaaaagc agctcgtgga gcgtcagatt      240

gccttgtttg agaaggaaaa tccgaacatc aaggtgagca tccaggtcat cacgggcaac      300

tacctgcagg cgctgcagcc gatgctcgcc gcgcacgacg cgccggacat cttctacgtg      360

gattcgtcct acgcgccgac gctcgaggct tcgggcgcca tcatgccgct cgacagcttc      420

atcaagcagg atcatgtcga tttgtccgac ttccagaaga acctgctcga cgcgttcacc      480

tggcaggggc acatctacgg cctgccgaag gacatgaaca cgatggcctt ggagtacaac      540

ccggcgctcc tcgccaaggc gggcatccag tcgccgccga agacgttcgc gcagtttgac      600

caggacgccg cgaagctcaa ggccaagggc attgtgccgc tggacatgcc gattgacgtg      660

gcgcgctatt atccgttcat cgtcgacatg ggcgggagct actacaacaa ggccacgaac      720

caggccacct tcaccaacaa ggcgaacgtc gcgggcctca cgtggtttat gaaagagatg      780

gaaagcggca acttcgtgac cccgcaagac caaggcgggt cctgggcggg tgtcccgttc      840

gcagagggca aggcggcgat ggcccttgag ggcgcttgga ttgtgccgtt catgcagcag      900

accgcgccga agatgaagta cggcattgcg gacttcccgt cgctcaacgg gcacgatgcg      960

aacatgctgt ttacggtcgc gtacgagatg tcgaagtacg cgaagaaccc ggatgctgcc     1020

gcgaagttgc tcttcttcat gacgggcaaa gaggcgctca agatgacggc cgattcgggc     1080

ctcgccattc cctctcggac cagcgagcag ggcgagtttc tgaagaagta tccgtcgtac     1140

aagggcttcg tggacggtct caagggcgcc attccgtatc agttcggcac gctcgggcag     1200

aacttcctcg acgccatcaa caatgccacg caacaaggca ttctgaagaa ggagtcggcg     1260

cagcaagtct tgagtcaggc gcagcagacg ctcgcttcac agatgaacga ctga           1314


<210>   462
<211>   387
<212>   PRT
<213>   Thermoanaerobacter pseudethanolicus ATCC 33223

<400>   462
Thr Ser Ser Ala Asn Glu Thr Asn Thr Gln Lys Gln Glu Thr Ala Lys 
                5                   10                  15      

Pro Val Thr Ile Lys Leu Gly Met Trp Ser Ser Ser Pro Ala Glu Lys 
            20                  25                  30          

Lys Ile Val Asp Asp Gln Ile Ala Lys Phe Lys Glu Lys Tyr Pro Asn 
        35                  40                  45              

Ile Asp Val Gln Ile Glu Thr Ile Val Gly Asp Tyr Met Gln Lys Leu 
    50                  55                  60                  

Gln Thr Glu Leu Ala Ser Asn Thr Ala Pro Asp Ile Phe Tyr Leu Asp 
65                  70                  75                  80  

Ser Met Pro Ala Pro Gln Leu Met Ser Ser Gly Val Leu Glu Pro Leu 
                85                  90                  95      

Asp Asp Tyr Ile Lys Lys Tyr Asn Val Asp Val Asn Asp Phe Glu Pro 
            100                 105                 110         

Ala Leu Leu Ser Ala Phe Gln Trp Asp Gly Lys Thr Tyr Gly Leu Pro 
        115                 120                 125             

Lys Asp Phe Asn Thr Leu Ala Leu Phe Tyr Asn Lys Asp Met Phe Lys 
    130                 135                 140                 

Ala Ala Gly Ile Asn Glu Pro Pro Lys Thr Trp Glu Glu Leu Arg Asp 
145                 150                 155                 160 

Val Ala Lys Lys Leu Thr Lys Asp Gly Val Lys Gly Leu Val Leu Ser 
                165                 170                 175     

Ala Asp Leu Ala Arg Phe Asp Ala Phe Ile Asn Gln Asn Gly Gly Ser 
            180                 185                 190         

Val Tyr Gln Asp Gly Lys Val Thr Leu Asn Leu Pro Glu Asn Ala Gln 
        195                 200                 205             

Ala Leu Asp Phe Tyr Val Ser Leu Ile Thr Lys Asp Lys Val Ala Asp 
    210                 215                 220                 

Thr Pro Gln Asn Met Gly Glu Gly Trp Asn Gly Asp Ala Phe Ala Ala 
225                 230                 235                 240 

Lys Lys Ala Ala Met Ala Ile Glu Gly Gly Trp Met Ile Pro Phe Leu 
                245                 250                 255     

Lys Glu Lys Ala Pro Asp Leu Asn Tyr Gly Ile Ala Glu Leu Pro Ala 
            260                 265                 270         

Gly Lys Gln Lys Ser Thr Met Ala Phe Thr Val Ala Tyr Val Met Asn 
        275                 280                 285             

Lys Asn Ser Lys His Lys Asp Glu Ala Phe Lys Leu Ile Glu Phe Leu 
    290                 295                 300                 

Thr Gly Lys Glu Gly Gln Gln Phe Val Val Asp Ser Gly Leu Ala Leu 
305                 310                 315                 320 

Pro Ser Arg Lys Ser Met Gln Glu Gly Phe Lys Glu Lys Tyr Pro Glu 
                325                 330                 335     

Arg Ala Ala Phe Val Asp Gly Ala Ser Tyr Ala Val Pro Trp Gln Phe 
            340                 345                 350         

Gly Leu Tyr Gly Thr Lys Val Val Asp Ala Ala Asn Lys Ala Cys Glu 
        355                 360                 365             

Ala Leu Ile Met Lys Gln Ile Ser Ser Ala Gln Gln Ala Leu Asp Asn 
    370                 375                 380                 

Ala Gln Lys 
385         

<210>   463
<211>   374
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   463
Thr Ser Lys Pro Val Thr Ile Lys Leu Gly Met Trp Ser Ser Ser Pro 
                5                   10                  15      

Ala Glu Lys Lys Ile Val Asp Asp Gln Ile Ala Lys Phe Lys Glu Lys 
            20                  25                  30          

Tyr Pro Asn Ile Asp Val Gln Ile Glu Thr Ile Val Gly Asp Tyr Met 
        35                  40                  45              

Gln Lys Leu Gln Thr Glu Leu Ala Ser Asn Thr Ala Pro Asp Ile Phe 
    50                  55                  60                  

Tyr Leu Asp Ser Met Pro Ala Pro Gln Leu Met Ser Ser Gly Val Leu 
65                  70                  75                  80  

Glu Pro Leu Asp Glu Tyr Ile Lys Lys Tyr Asn Val Asp Val Asn Asp 
                85                  90                  95      

Phe Glu Pro Ala Leu Leu Ser Ala Phe Gln Trp Glu Gly Lys Thr Tyr 
            100                 105                 110         

Gly Leu Pro Lys Asp Tyr Asn Thr Leu Val Leu Phe Tyr Asn Lys Asp 
        115                 120                 125             

Met Phe Lys Glu Ala Gly Ile Asn Glu Pro Pro Lys Thr Trp Glu Glu 
    130                 135                 140                 

Leu Arg Glu Thr Ala Lys Lys Leu Thr Lys Asn Gly Val Lys Gly Ile 
145                 150                 155                 160 

Val Leu Ser Ala Asp Leu Ala Arg Phe Asp Ala Phe Ile Asn Gln Asn 
                165                 170                 175     

Asp Gly Ser Val Tyr Lys Asp Gly Lys Val Thr Leu Asn Leu Pro Gln 
            180                 185                 190         

Asn Ala Glu Ala Leu Asp Phe Tyr Val Gly Leu Ile Ile Arg Asp Lys 
        195                 200                 205             

Val Ala Asp Thr Pro Gln Asn Met Gly Glu Gly Trp Asn Gly Asp Ala 
    210                 215                 220                 

Phe Ala Ala Lys Lys Ala Ala Met Ala Ile Glu Gly Gly Trp Met Ile 
225                 230                 235                 240 

Pro Phe Leu Lys Glu Lys Ala Pro Asp Leu Asn Tyr Gly Ile Ala Glu 
                245                 250                 255     

Leu Pro Ala Gly Lys Lys Lys Ser Thr Met Ala Phe Thr Val Ala Tyr 
            260                 265                 270         

Val Met Asn Lys Asn Ser Lys His Lys Asp Glu Ala Phe Lys Leu Ile 
        275                 280                 285             

Glu Phe Leu Thr Gly Lys Glu Gly Gln Gln Phe Val Val Asp Ser Gly 
    290                 295                 300                 

Leu Ala Leu Pro Ser Arg Lys Ser Met Glu Ala Asn Phe Lys Glu Lys 
305                 310                 315                 320 

Tyr Pro Glu Arg Ala Pro Phe Ile Asp Gly Ala Ser Tyr Ala Val Pro 
                325                 330                 335     

Trp Gln Phe Gly Leu Tyr Gly Thr Lys Leu Val Asp Ala Ala Asn Lys 
            340                 345                 350         

Ala Cys Glu Ala Leu Ile Met Lys Gln Ile Gly Ser Ala Gln Glu Ala 
        355                 360                 365             

Leu Asp Asn Ala Gln Lys 
    370                 

<210>   464
<211>   363
<212>   PRT
<213>   Caldicellulosiruptor saccharolyticus DSM 8903

<400>   464
Ala Ala Ser Lys Ile Thr Leu Lys Leu Gly Ala Trp Ala Ser Ser Pro 
                5                   10                  15      

Ala Glu Lys Lys Ile Val Gln Asn Gln Ile Ala Ala Phe Lys Lys Leu 
            20                  25                  30          

Tyr Pro Asn Val Asp Val Arg Ile Thr Glu Ile Val Gly Asp Tyr Asn 
        35                  40                  45              

Gln Lys Ile Gln Leu Leu Met Ala Ser Lys Thr Glu Pro Asp Ile Phe 
    50                  55                  60                  

Tyr Met Asp Ser Met Pro Ala Trp Gln Tyr Ile Ala Lys Gly Val Leu 
65                  70                  75                  80  

Glu Pro Leu Asp Tyr Trp Met Lys Lys Tyr Asn Val Lys Thr Ile Gly 
                85                  90                  95      

Tyr Glu Ser Ser Leu Leu Gln Pro Phe Ile Tyr Lys Gly Lys Val Tyr 
            100                 105                 110         

Gly Leu Pro Lys Asp Tyr Asn Thr Leu Val Leu Phe Tyr Asn Lys Glu 
        115                 120                 125             

Met Phe Lys Gln Ala Gly Leu Thr Arg Pro Pro Arg Thr Trp Gln Glu 
    130                 135                 140                 

Leu Lys Asp Tyr Ala Lys Lys Leu Thr Thr Gly Lys Val Val Gly Leu 
145                 150                 155                 160 

Thr Met Asn Leu Glu Leu Ala Arg Ile Gln Pro Phe Ala Tyr Gln Asn 
                165                 170                 175     

Gly Gly Lys Val Phe Asp Gly Thr Lys Pro Val Phe Thr Asp Pro Lys 
            180                 185                 190         

Ala Leu Glu Gly Phe Lys Phe Ala Leu Asp Leu Phe Lys Glu Gly Ile 
        195                 200                 205             

Cys Lys Thr Pro Lys Asp Leu Gly Ala Gly Trp Val Gly Asp Ala Phe 
    210                 215                 220                 

Ala Asp Lys Lys Ala Ala Met Thr Ile Glu Gly Gly Trp Met Ile Pro 
225                 230                 235                 240 

Phe Leu Asn Glu Arg Lys Ile Pro Lys Asp Ser Tyr Gly Ile Ala Glu 
                245                 250                 255     

Leu Pro Ala Gly Pro Ala Gly Lys Ser Thr Met Ala Phe Thr Val Ala 
            260                 265                 270         

Tyr Val Met Ser Lys Asn Ser Lys His Lys Pro Glu Ala Phe Lys Leu 
        275                 280                 285             

Ile Arg Phe Leu Thr Gly Glu Gly Gly Gln Lys Phe Val Val Glu Ala 
    290                 295                 300                 

Gly Leu Ala Leu Pro Ser Leu Lys Ser Ala Gly Val Asn Phe Ala Lys 
305                 310                 315                 320 

Thr Tyr Pro Glu Arg Lys Ala Leu Val Asp Gly Ala Lys Tyr Ala Gln 
                325                 330                 335     

Val Tyr Phe Tyr Gly Leu Asp Gly Thr Lys Val Val Asp Val Phe Asn 
            340                 345                 350         

Lys Ala Phe Glu Asp Tyr Val Ile Gly Lys Lys 
        355                 360             

<210>   465
<211>   390
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   465
Ser Glu Gln Ala Asn Gly Gly Asn Lys Gln Gly Glu Lys Val Glu Val 
                5                   10                  15      

Thr Leu Ala Gly Trp Gly Gly Asn Pro Ser Glu Gln Lys Leu Leu Gln 
            20                  25                  30          

Gln Thr Ile Asp Asp Phe Glu Lys Lys His Pro Asp Ile Lys Val Lys 
        35                  40                  45              

Tyr Glu Val Ile Ala Asp Gln Tyr Met Asp Val Ile Lys Thr Arg Leu 
    50                  55                  60                  

Ser Gly Gly Gln Gly Pro Asp Val Phe Tyr Leu Asp Ala Phe Glu Ala 
65                  70                  75                  80  

Pro Ala Leu Ile Glu Thr Gly Ala Leu Glu Pro Leu Asp Glu Tyr Val 
                85                  90                  95      

Thr Asp Glu Phe Asp Ile Asp Asp Phe Glu Lys Pro Met Leu Asp Ala 
            100                 105                 110         

Phe Lys Gly Glu Asp Gly Lys Ile Tyr Gly Phe Pro Lys Asp Tyr Ser 
        115                 120                 125             

Thr Leu Ala Leu Phe Tyr Asn Lys Lys Met Leu Glu Glu Ala Gly Val 
    130                 135                 140                 

Glu Val Pro Lys Thr Trp Asp Glu Leu Arg Glu Ala Ala Lys Lys Leu 
145                 150                 155                 160 

Thr Lys Gly Lys Asp Val Tyr Gly Phe Gly Val Ala Pro Glu Leu Ala 
                165                 170                 175     

Arg Leu Tyr Tyr Ile Ala Glu Ser Lys Gly Gly Lys Val Val Thr Asp 
            180                 185                 190         

Asn Lys Ala Ser Phe Ala Asp Ser Lys Val Val Asp Ala Leu Gln Pro 
        195                 200                 205             

Ile Val Asp Met His Leu Lys Asp Lys Thr Ala Ala Gln Pro Asn Glu 
    210                 215                 220                 

Val Gly Ala Thr Trp Gly Gly Glu Met Phe Gly Gln Gly Lys Ala Ala 
225                 230                 235                 240 

Met Val Ile Glu Gly Asn Trp Ala Ile Pro Phe Leu Gln Asp Thr Phe 
                245                 250                 255     

Pro Asn Leu Glu Phe Gly Thr Ala Glu Leu Pro Thr Ile Asn Gly Lys 
            260                 265                 270         

Lys Ala Thr Met Ala Tyr Thr Val Ala Tyr Val Met Asn Lys Asp Ser 
        275                 280                 285             

Gln Lys Lys Glu Ala Ala Trp Lys Leu Ile Ser Tyr Leu Thr Gly Lys 
    290                 295                 300                 

Glu Gly Met Lys Thr Trp Thr Ser Lys Gly Tyr Ala Leu Pro Thr Arg 
305                 310                 315                 320 

Lys Ser Val Ala Ala Glu Leu Gly Phe Asp Lys Asp Pro Leu Arg Ala 
                325                 330                 335     

Ala Leu Val Ala Gly Ala Pro Tyr Ala Thr Val Trp Gln Asn Gly Thr 
            340                 345                 350         

Asn Leu Pro Ile Ile Val Asn Asn Phe Asn Asn Gln Phe Val Ser Ala 
        355                 360                 365             

Phe Leu Gly Glu Arg Pro Leu Ala Asp Ala Leu Lys Glu Ala Glu Lys 
    370                 375                 380                 

Thr Ala Asn Ser Glu Ile 
385                 390 

<210>   466
<211>   398
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   466
Cys Asn Phe Ala Asp Glu Glu Pro Ser Ser Glu Pro Thr Glu Gly Gly 
                5                   10                  15      

Asn Thr Asp Gly Glu Val Val Glu Leu Thr Leu Thr Gly Trp Gln Ser 
            20                  25                  30          

Ser Pro Thr Glu Gln Arg Tyr Phe Glu Glu Thr Val Ala Thr Phe Glu 
        35                  40                  45              

Glu Gln Asn Pro Asp Ile Lys Val Asn Ile Asn Thr Ile Pro Asp Gln 
    50                  55                  60                  

Tyr Met Asp Val Leu Arg Thr Arg Leu Ile Gly Gly Glu Gly Pro Asp 
65                  70                  75                  80  

Val Phe Phe Leu Asp Ala Phe Glu Ala Pro Gly Leu Ile Glu Thr Gly 
                85                  90                  95      

Ala Val Glu Pro Leu Asp Glu Tyr Ile Thr Asp Glu Phe Asp Leu Ala 
            100                 105                 110         

Asp Phe Glu Gln Pro Leu Leu Glu Ala Phe Glu Arg Asn Gly Val Leu 
        115                 120                 125             

Tyr Gly Leu Pro Lys Asp Thr Ser Thr Leu Ala Leu Phe Tyr Asn Ile 
    130                 135                 140                 

Asp Met Leu Glu Glu Ala Gly Phe Asp Gly Pro Pro Glu Thr Trp Glu 
145                 150                 155                 160 

Glu Leu Glu Glu Met Ala Ile Ala Leu Thr Asn Asp Asp Glu Tyr Gly 
                165                 170                 175     

Phe Gly Val Val Thr Asp Leu Ala Arg Leu Met Phe Ile Ala Gln Ser 
            180                 185                 190         

Asn Gly Gly Gln Ile Ala Thr Asp Asn Gln Ala Thr Phe Ala Asp Pro 
        195                 200                 205             

Arg Val Val Glu Ala Leu Gln Pro Ile Val Asp Met Arg Asn Val Asp 
    210                 215                 220                 

Gly Ser Ala Val Glu Pro Ser Glu Val Gly Ala Asp Trp Gly Gly Glu 
225                 230                 235                 240 

Met Phe Gly Leu Glu Arg Val Ala Met Val Ile Glu Gly Asn Trp Thr 
                245                 250                 255     

Val Pro Phe Leu Asp Glu Asn Phe Glu Asp Val Asn Tyr Gly Val Ala 
            260                 265                 270         

Glu Val Pro Thr Ile Asn Gly Asn Glu Gly Thr Met Ala Tyr Thr Val 
        275                 280                 285             

Ser Tyr Val Met Asn Arg Asn Ser Glu His Lys Glu Glu Ala Trp Arg 
    290                 295                 300                 

Leu Ile Glu Phe Leu Thr Gly Lys Glu Gly Met Glu Leu Trp Thr Ser 
305                 310                 315                 320 

Ser Gly Leu Thr Leu Pro Thr Arg Ala Ser Val Ser Glu Lys Leu Asp 
                325                 330                 335     

Tyr Ala Asp Asp Pro Ile Tyr Gly Pro Phe Ile Ala Gly Gln Ser Tyr 
            340                 345                 350         

Ala Thr Val Trp Ala Asp Asp Thr Asn Leu Pro Ile Val Asn Asn Asn 
        355                 360                 365             

Phe Gln Asn Gln Phe Thr Ser Ala Phe Leu Gly Gln Arg Asp Leu Ala 
    370                 375                 380                 

Glu Ala Leu Lys Glu Ala Glu Glu Val Ala Asn Ser Glu Ile 
385                 390                 395             

<210>   467
<211>   437
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   467
Met Glu Thr Ser Gly Val Lys Pro Ile Gly Trp Glu Val Glu Arg Lys 
                5                   10                  15      

Met Arg Lys Pro Phe Leu Gly Ile Ala Gly Ala Ala Val Val Ala Met 
            20                  25                  30          

Gly Ala Val Thr Ala Cys Gly Gln Ala Gln Ser Ala Pro Ser Asn Gln 
        35                  40                  45              

Ala Asn Val Gly Ser Ala Ser Ala Ala Pro Ile His Leu Thr Leu Gly 
    50                  55                  60                  

Met Trp Ala Ser Ser Pro Ala Glu Lys Gln Leu Val Glu Arg Gln Ile 
65                  70                  75                  80  

Ala Leu Phe Glu Lys Glu Asn Pro Asn Ile Lys Val Ser Ile Gln Val 
                85                  90                  95      

Ile Thr Gly Asn Tyr Leu Gln Ala Leu Gln Pro Met Ile Ala Ala His 
            100                 105                 110         

Asp Ala Pro Asp Ile Phe Tyr Val Asp Ser Ser Tyr Ala Pro Thr Leu 
        115                 120                 125             

Glu Ala Ser Gly Ala Ile Met Pro Leu Asp Ser Phe Ile Lys Gln Asp 
    130                 135                 140                 

His Val Asp Leu Ser Asp Phe Gln Lys Asn Leu Leu Asp Ala Phe Thr 
145                 150                 155                 160 

Trp Gln Gly His Ile Tyr Gly Leu Pro Lys Asp Met Asn Thr Met Ala 
                165                 170                 175     

Leu Glu Tyr Asn Pro Ala Leu Leu Ala Lys Ala Gly Ile Gln Ser Pro 
            180                 185                 190         

Pro Lys Thr Phe Ala Gln Phe Asp Gln Asp Ala Ala Lys Leu Lys Ala 
        195                 200                 205             

Lys Gly Ile Val Pro Leu Asp Met Pro Ile Asp Val Ala Arg Tyr Tyr 
    210                 215                 220                 

Pro Phe Ile Val Asp Met Gly Gly Ser Tyr Tyr Asn Lys Ala Thr Asn 
225                 230                 235                 240 

Gln Ala Thr Phe Thr Asn Lys Ala Asn Val Ala Gly Leu Thr Trp Phe 
                245                 250                 255     

Met Lys Glu Met Glu Ser Gly Asn Phe Val Thr Pro Gln Asp Gln Gly 
            260                 265                 270         

Gly Ser Trp Ala Gly Val Pro Phe Ala Glu Gly Lys Ala Ala Met Ala 
        275                 280                 285             

Leu Glu Gly Ala Trp Ile Val Pro Phe Met Gln Gln Thr Ala Pro Lys 
    290                 295                 300                 

Met Lys Tyr Gly Ile Ala Asp Phe Pro Ser Leu Asn Gly His Asp Ala 
305                 310                 315                 320 

Asn Met Leu Phe Thr Val Ala Tyr Glu Met Ser Lys Tyr Ala Lys Asn 
                325                 330                 335     

Pro Asp Ala Ala Ala Lys Leu Leu Phe Phe Met Thr Gly Lys Glu Ala 
            340                 345                 350         

Leu Lys Met Thr Ala Asp Ser Gly Leu Ala Ile Pro Ser Arg Thr Ser 
        355                 360                 365             

Glu Gln Gly Glu Phe Leu Lys Lys Tyr Pro Ser Tyr Lys Gly Phe Val 
    370                 375                 380                 

Asp Gly Leu Lys Gly Ala Ile Pro Tyr Gln Phe Gly Thr Leu Gly Gln 
385                 390                 395                 400 

Asn Phe Leu Asp Ala Ile Asn Asn Ala Thr Gln Gln Gly Ile Leu Lys 
                405                 410                 415     

Lys Glu Ser Ala Gln Gln Val Leu Ser Gln Ala Gln Gln Thr Leu Ala 
            420                 425                 430         

Ser Gln Met Asn Asp 
        435         

<210>   468
<211>   437
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   468
Met Glu Thr Ser Gly Val Lys Pro Ile Gly Trp Glu Val Glu Arg Lys 
                5                   10                  15      

Met Arg Lys Pro Phe Leu Gly Ile Ala Gly Ala Ala Val Val Ala Met 
            20                  25                  30          

Gly Ala Val Thr Ala Cys Gly Gln Ala Gln Ser Ala Pro Ser Asn Gln 
        35                  40                  45              

Ala Asn Val Gly Ser Ala Ser Ala Ala Pro Ile His Leu Thr Leu Gly 
    50                  55                  60                  

Met Trp Ala Ser Ser Pro Ala Glu Lys Gln Leu Val Glu Arg Gln Ile 
65                  70                  75                  80  

Ala Leu Phe Glu Lys Glu Asn Pro Asn Ile Lys Val Ser Ile Gln Val 
                85                  90                  95      

Ile Thr Gly Asn Tyr Leu Gln Ala Leu Gln Pro Met Leu Ala Ala His 
            100                 105                 110         

Asp Ala Pro Asp Ile Phe Tyr Val Asp Ser Ser Tyr Ala Pro Thr Leu 
        115                 120                 125             

Glu Ala Ser Gly Ala Ile Met Pro Leu Asp Ser Phe Ile Lys Gln Asp 
    130                 135                 140                 

His Val Asp Leu Ser Asp Phe Gln Lys Asn Leu Leu Asp Ala Phe Thr 
145                 150                 155                 160 

Trp Gln Gly His Ile Tyr Gly Leu Pro Lys Asp Met Asn Thr Met Ala 
                165                 170                 175     

Leu Glu Tyr Asn Pro Ala Leu Leu Ala Lys Ala Gly Ile Gln Ser Pro 
            180                 185                 190         

Pro Lys Thr Phe Ala Gln Phe Asp Gln Asp Ala Ala Lys Leu Lys Ala 
        195                 200                 205             

Lys Gly Ile Val Pro Leu Asp Met Pro Ile Asp Val Ala Arg Tyr Tyr 
    210                 215                 220                 

Pro Phe Ile Val Asp Met Gly Gly Ser Tyr Tyr Asn Lys Ala Thr Asn 
225                 230                 235                 240 

Gln Ala Thr Phe Thr Asn Lys Ala Asn Val Ala Gly Leu Thr Trp Phe 
                245                 250                 255     

Met Lys Glu Met Glu Ser Gly Asn Phe Val Thr Pro Gln Asp Gln Gly 
            260                 265                 270         

Gly Ser Trp Ala Gly Val Pro Phe Ala Glu Gly Lys Ala Ala Met Ala 
        275                 280                 285             

Leu Glu Gly Ala Trp Ile Val Pro Phe Met Gln Gln Thr Ala Pro Lys 
    290                 295                 300                 

Met Lys Tyr Gly Ile Ala Asp Phe Pro Ser Leu Asn Gly His Asp Ala 
305                 310                 315                 320 

Asn Met Ile Phe Thr Val Ala Tyr Glu Met Ser Lys Tyr Ala Lys Asn 
                325                 330                 335     

Pro Asp Ala Ala Ala Lys Leu Leu Phe Phe Met Thr Gly Lys Glu Ala 
            340                 345                 350         

Leu Lys Met Thr Ala Asp Ser Gly Leu Ala Ile Pro Ser Arg Thr Ser 
        355                 360                 365             

Glu Gln Gly Glu Phe Leu Lys Lys Tyr Pro Ser Tyr Lys Gly Phe Val 
    370                 375                 380                 

Asp Gly Leu Lys Gly Ala Ile Pro Tyr Gln Phe Gly Thr Leu Gly Gln 
385                 390                 395                 400 

Asn Phe Leu Asp Ala Ile Asn Asn Ala Thr Gln Gln Gly Ile Leu Lys 
                405                 410                 415     

Lys Glu Ser Ala Gln Gln Val Leu Ser Gln Ala Gln Gln Thr Leu Ala 
            420                 425                 430         

Ser Gln Met Asn Asp 
        435         

<210>   469
<211>   437
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   469
Met Glu Thr Ser Gly Val Lys Pro Ile Gly Trp Glu Val Glu Arg Lys 
                5                   10                  15      

Met Arg Lys Pro Phe Leu Gly Ile Ala Gly Ala Ala Val Val Ala Met 
            20                  25                  30          

Gly Ala Val Thr Ala Cys Gly Gln Ala Gln Ser Ala Pro Ser Asn Gln 
        35                  40                  45              

Ala Asn Val Gly Ser Ala Ser Ala Ala Pro Ile His Leu Thr Leu Gly 
    50                  55                  60                  

Met Trp Ala Ser Ser Pro Ala Glu Lys Gln Leu Val Glu Arg Gln Ile 
65                  70                  75                  80  

Ala Leu Phe Glu Lys Glu Asn Pro Asn Ile Lys Val Ser Ile Gln Val 
                85                  90                  95      

Ile Thr Gly Asn Tyr Leu Gln Ala Leu Gln Pro Met Leu Ala Ala His 
            100                 105                 110         

Asp Ala Pro Asp Ile Phe Tyr Val Asp Ser Ser Tyr Ala Pro Thr Leu 
        115                 120                 125             

Glu Ala Ser Gly Ala Ile Met Pro Leu Asp Ser Phe Ile Lys Gln Asp 
    130                 135                 140                 

His Val Asp Leu Ser Asp Phe Gln Lys Asn Leu Leu Asp Ala Phe Thr 
145                 150                 155                 160 

Trp Gln Gly His Ile Tyr Gly Leu Pro Lys Asp Met Asn Thr Met Ala 
                165                 170                 175     

Leu Glu Tyr Asn Pro Ala Leu Leu Ala Lys Ala Gly Ile Gln Ser Pro 
            180                 185                 190         

Pro Lys Thr Phe Ala Gln Phe Asp Gln Glu Ala Ala Lys Leu Lys Ala 
        195                 200                 205             

Lys Gly Ile Val Pro Leu Asp Met Pro Ile Asp Val Ala Arg Tyr Tyr 
    210                 215                 220                 

Pro Phe Ile Val Asp Met Gly Gly Ser Tyr Tyr Asn Lys Ala Thr Asn 
225                 230                 235                 240 

Gln Ala Thr Phe Thr Asn Lys Ala Asn Val Ala Gly Leu Thr Trp Phe 
                245                 250                 255     

Met Lys Glu Met Glu Ser Gly Asn Phe Val Thr Pro Gln Asp Gln Gly 
            260                 265                 270         

Gly Ser Trp Ala Gly Val Pro Phe Ala Glu Gly Lys Ala Ala Met Ala 
        275                 280                 285             

Leu Glu Gly Ala Trp Ile Val Pro Phe Met Gln Gln Thr Ala Pro Lys 
    290                 295                 300                 

Met Lys Tyr Gly Ile Ala Asp Phe Pro Ser Leu Asn Gly His Asp Ala 
305                 310                 315                 320 

Asn Met Leu Phe Thr Val Ala Tyr Glu Met Ser Lys Tyr Ala Lys Asn 
                325                 330                 335     

Pro Asp Ala Ala Ala Lys Leu Leu Phe Phe Met Thr Gly Lys Glu Ala 
            340                 345                 350         

Leu Lys Met Thr Ala Asp Ser Gly Leu Ala Ile Pro Ser Arg Thr Ser 
        355                 360                 365             

Glu Gln Gly Glu Phe Leu Lys Lys Tyr Pro Ser Tyr Lys Gly Phe Val 
    370                 375                 380                 

Asp Gly Leu Lys Gly Ala Ile Pro Tyr Gln Phe Gly Thr Leu Gly Gln 
385                 390                 395                 400 

Asn Phe Leu Asp Ala Ile Asn Asn Ala Thr Gln Gln Gly Ile Leu Lys 
                405                 410                 415     

Lys Glu Ser Ala Gln Gln Val Leu Ser Gln Ala Gln Gln Thr Leu Ala 
            420                 425                 430         

Ser Gln Met Asn Asp 
        435         

<210>   470
<211>   437
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   470
Met Glu Thr Ser Gly Val Lys Pro Ile Gly Trp Glu Val Glu Arg Lys 
                5                   10                  15      

Met Arg Arg Pro Phe Leu Gly Ile Ala Gly Ala Ala Val Val Ala Met 
            20                  25                  30          

Gly Ala Val Thr Ala Cys Gly Gln Ala Gln Ser Ala Pro Ser Asn Gln 
        35                  40                  45              

Ala Asn Val Gly Ser Ala Ser Ala Ala Pro Ile His Leu Thr Leu Gly 
    50                  55                  60                  

Met Trp Ala Ser Ser Pro Ala Glu Lys Gln Leu Val Glu Arg Gln Ile 
65                  70                  75                  80  

Ala Leu Phe Glu Lys Glu Asn Pro Asn Ile Lys Val Ser Ile Gln Val 
                85                  90                  95      

Ile Thr Gly Asn Tyr Leu Gln Ala Leu Gln Pro Met Leu Ala Ala His 
            100                 105                 110         

Asp Ala Pro Asp Ile Phe Tyr Val Asp Ser Ser Tyr Ala Pro Thr Leu 
        115                 120                 125             

Glu Ala Ser Gly Ala Ile Met Pro Leu Asp Ser Phe Ile Lys Gln Asp 
    130                 135                 140                 

His Val Asp Leu Ser Asp Phe Gln Lys Asn Leu Leu Asp Ala Phe Thr 
145                 150                 155                 160 

Trp Gln Gly His Ile Tyr Gly Leu Pro Lys Asp Met Asn Thr Met Ala 
                165                 170                 175     

Leu Glu Tyr Asn Pro Ala Leu Leu Ala Lys Ala Gly Ile Gln Ser Pro 
            180                 185                 190         

Pro Lys Thr Phe Ala Gln Phe Asp Gln Asp Ala Ala Lys Leu Lys Ala 
        195                 200                 205             

Lys Gly Ile Val Pro Leu Asp Met Pro Ile Asp Val Ala Arg Tyr Tyr 
    210                 215                 220                 

Pro Phe Ile Val Asp Met Gly Gly Ser Tyr Tyr Asn Lys Ala Thr Asn 
225                 230                 235                 240 

Gln Ala Thr Phe Thr Asn Lys Ala Asn Val Ala Gly Leu Thr Trp Phe 
                245                 250                 255     

Met Lys Glu Met Glu Ser Gly Asn Phe Val Thr Pro Gln Asp Gln Gly 
            260                 265                 270         

Gly Ser Trp Ala Gly Val Pro Phe Ala Glu Gly Lys Ala Ala Met Ala 
        275                 280                 285             

Leu Glu Gly Ala Trp Ile Val Pro Phe Met Gln Gln Thr Ala Pro Lys 
    290                 295                 300                 

Met Lys Tyr Gly Ile Ala Asp Phe Pro Ser Leu Asn Gly His Asp Ala 
305                 310                 315                 320 

Asn Met Leu Phe Thr Val Ala Tyr Glu Met Ser Lys Tyr Ala Lys Asn 
                325                 330                 335     

Pro Asp Ala Ala Ala Lys Leu Leu Phe Phe Met Thr Gly Lys Glu Ala 
            340                 345                 350         

Leu Lys Met Thr Ala Asp Ser Gly Leu Ala Ile Pro Ser Arg Thr Ser 
        355                 360                 365             

Glu Gln Gly Glu Phe Leu Lys Lys Tyr Pro Ser Tyr Lys Gly Phe Val 
    370                 375                 380                 

Asp Gly Leu Lys Gly Ala Ile Pro Tyr Gln Phe Gly Thr Leu Gly Gln 
385                 390                 395                 400 

Asn Phe Leu Asp Ala Ile Asn Asn Ala Thr Gln Gln Gly Ile Leu Lys 
                405                 410                 415     

Lys Glu Ser Ala Gln Gln Val Leu Ser Gln Ala Gln Gln Thr Leu Ala 
            420                 425                 430         

Ser Gln Met Asn Asp 
        435         

<210>   471
<211>   437
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 460

<400>   471
Met Glu Thr Ser Gly Val Lys Pro Ile Gly Trp Glu Val Glu Arg Lys 
                5                   10                  15      

Met Arg Lys Pro Phe Leu Gly Ile Ala Gly Ala Ala Val Val Ala Met 
            20                  25                  30          

Gly Ala Val Thr Ala Cys Gly Gln Ala Gln Ser Ala Pro Ser Asn Gln 
        35                  40                  45              

Ala Asn Val Gly Ser Ala Ser Ala Ala Pro Ile His Leu Thr Leu Gly 
    50                  55                  60                  

Met Trp Ala Ser Ser Pro Ala Glu Lys Gln Leu Val Glu Arg Gln Ile 
65                  70                  75                  80  

Ala Leu Phe Glu Lys Glu Asn Pro Asn Leu Lys Val Ser Ile Gln Val 
                85                  90                  95      

Ile Thr Gly Asn Tyr Leu Gln Ala Leu Gln Pro Met Leu Ala Ala His 
            100                 105                 110         

Asp Ala Pro Asp Ile Phe Tyr Val Asp Ser Ser Tyr Ala Pro Thr Leu 
        115                 120                 125             

Glu Ala Ser Gly Ala Ile Met Pro Leu Asp Ser Phe Ile Lys Gln Asp 
    130                 135                 140                 

His Val Asp Leu Ser Asp Phe Gln Lys Asn Leu Leu Asp Ala Phe Thr 
145                 150                 155                 160 

Trp Gln Gly His Ile Tyr Gly Leu Pro Lys Asp Met Asn Thr Met Ala 
                165                 170                 175     

Leu Glu Tyr Asn Pro Ala Leu Leu Ala Lys Ala Gly Ile Gln Ser Pro 
            180                 185                 190         

Pro Lys Thr Phe Ala Gln Phe Asp Gln Asp Ala Ala Lys Leu Lys Ala 
        195                 200                 205             

Lys Gly Ile Val Pro Leu Asp Met Pro Ile Asp Val Ala Arg Tyr Tyr 
    210                 215                 220                 

Pro Phe Ile Val Asp Met Gly Gly Ser Tyr Tyr Asn Lys Ala Thr Asn 
225                 230                 235                 240 

Gln Ala Thr Phe Thr Asn Lys Ala Asn Val Ala Gly Leu Thr Trp Phe 
                245                 250                 255     

Met Lys Glu Met Glu Ser Gly Asn Phe Val Thr Pro Gln Asp Gln Gly 
            260                 265                 270         

Gly Ser Trp Ala Gly Val Pro Phe Ala Glu Gly Lys Ala Ala Met Ala 
        275                 280                 285             

Leu Glu Gly Ala Trp Ile Val Pro Phe Met Gln Gln Thr Ala Pro Lys 
    290                 295                 300                 

Met Lys Tyr Gly Ile Ala Asp Phe Pro Ser Leu Asn Gly His Asp Ala 
305                 310                 315                 320 

Asn Met Leu Phe Thr Val Ala Tyr Glu Met Ser Lys Tyr Ala Lys Asn 
                325                 330                 335     

Pro Asp Ala Ala Ala Lys Leu Leu Phe Phe Met Thr Gly Lys Glu Ala 
            340                 345                 350         

Leu Lys Met Thr Ala Asp Ser Gly Leu Ala Ile Pro Ser Arg Thr Ser 
        355                 360                 365             

Glu Gln Gly Glu Phe Leu Lys Lys Tyr Pro Ser Tyr Lys Gly Phe Val 
    370                 375                 380                 

Asp Gly Leu Lys Gly Ala Ile Pro Tyr Gln Phe Gly Thr Leu Gly Gln 
385                 390                 395                 400 

Asn Phe Leu Asp Ala Ile Asn Asn Ala Thr Gln Gln Gly Ile Leu Lys 
                405                 410                 415     

Lys Glu Ser Ala Gln Gln Val Leu Ser Gln Ala Gln Gln Thr Leu Ala 
            420                 425                 430         

Ser Gln Met Asn Asp 
        435         

<210>   472
<211>   1314
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   472
atggagacaa gcggggtcaa accgattggg tgggaggtcg aacgaaagat gaggaaacca       60

tttcttggga tcgcgggtgc ggcagtggtc gcgatgggcg cggtgacggc atgcggccag      120

gcgcagagcg cgccctccaa ccaggcgaac gtcggcagcg cgtcggcggc gcccattcat      180

ctgacgcttg gcatgtgggc gtcgagcccg gcggaaaagc agctcgtgga gcgtcagatt      240

gccttgtttg agaaggaaaa tccgaacatc aaggtgagca tccaggtcat cacgggcaac      300

tacctgcagg cgctgcagcc gatgattgcc gcgcacgacg cgccggacat cttctacgtg      360

gattcgtcct acgcgccgac gctcgaggct tcgggcgcca tcatgccgct cgacagcttc      420

atcaagcagg atcatgtcga tttgtccgac ttccagaaga acctgctcga cgcgttcacc      480

tggcaggggc acatctacgg cctgccgaag gacatgaaca cgatggcctt ggagtacaac      540

ccggcgctcc tcgccaaggc gggcatccag tcgccgccga agacgttcgc gcagtttgac      600

caggacgccg cgaagctcaa ggccaagggc attgtgccgc tggacatgcc gattgacgtg      660

gcgcgctatt atccgttcat cgtcgacatg ggcgggagct actacaacaa ggccacgaac      720

caggccacct tcaccaacaa ggcgaacgtc gcgggcctca cgtggtttat gaaagagatg      780

gaaagcggca acttcgtgac cccgcaagac caaggcgggt cctgggcggg tgtcccgttc      840

gcagagggca aggcggcgat ggcccttgag ggcgcttgga ttgtgccgtt catgcagcag      900

accgcgccga agatgaagta cggcattgcg gacttcccgt cgctcaacgg gcacgatgcg      960

aacatgctgt ttacggtcgc gtacgagatg tcgaagtacg cgaagaaccc ggatgctgcc     1020

gcgaagttgc tcttcttcat gacgggcaaa gaggcgctca agatgacggc cgattcgggc     1080

ctcgccattc cctctcggac cagcgagcag ggcgagtttc tgaagaagta tccgtcgtac     1140

aagggcttcg tggacggtct caagggcgcc attccgtatc agttcggcac gctcgggcag     1200

aacttcctcg acgccatcaa caatgccacg caacaaggca ttctgaagaa ggagtcggcg     1260

cagcaagtct tgagtcaggc gcagcagacg ctcgcttcac agatgaacga ctga           1314


<210>   473
<211>   1314
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   473
atggagacaa gcggggtcaa accgattggg tgggaggtcg aacgaaagat gaggaaacca       60

tttcttggga tcgcgggtgc ggcagtggtc gcgatgggcg cggtgacggc atgcggccag      120

gcgcagagcg cgccctccaa ccaggcgaac gtcggcagcg cgtcggcggc gcccattcat      180

ctgacgcttg gcatgtgggc gtcgagcccg gcggaaaagc agctcgtgga gcgtcagatt      240

gccttgtttg agaaggaaaa tccgaacatc aaggtgagca tccaggtcat cacgggcaac      300

tacctgcagg cgctgcagcc gatgctcgcc gcgcacgacg cgccggacat cttctacgtg      360

gattcgtcct acgcgccgac gctcgaggct tcgggcgcca tcatgccgct cgacagcttc      420

atcaagcagg atcatgtcga tttgtccgac ttccagaaga acctgctcga cgcgttcacc      480

tggcaggggc acatctacgg cctgccgaag gacatgaaca cgatggcctt ggagtacaac      540

ccggcgctcc tcgccaaggc gggcatccag tcgccgccga agacgttcgc gcagtttgac      600

caggacgccg cgaagctcaa ggccaagggc attgtgccgc tggacatgcc gattgacgtg      660

gcgcgctatt atccgttcat cgtcgacatg ggcgggagct actacaacaa ggccacgaac      720

caggccacct tcaccaacaa ggcgaacgtc gcgggcctca cgtggtttat gaaagagatg      780

gaaagcggca acttcgtgac cccgcaagac caaggcgggt cctgggcggg tgtcccgttc      840

gcagagggca aggcggcgat ggcccttgag ggcgcttgga ttgtgccgtt catgcagcag      900

accgcgccga agatgaagta cggcattgcg gacttcccgt cgctcaacgg gcacgatgcg      960

aacatgattt ttacggtcgc gtacgagatg tcgaagtacg cgaagaaccc ggatgctgcc     1020

gcgaagttgc tcttcttcat gacgggcaaa gaggcgctca agatgacggc cgattcgggc     1080

ctcgccattc cctctcggac cagcgagcag ggcgagtttc tgaagaagta tccgtcgtac     1140

aagggcttcg tggacggtct caagggcgcc attccgtatc agttcggcac gctcgggcag     1200

aacttcctcg acgccatcaa caatgccacg caacaaggca ttctgaagaa ggagtcggcg     1260

cagcaagtct tgagtcaggc gcagcagacg ctcgcttcac agatgaacga ctga           1314


<210>   474
<211>   1314
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   474
atggagacaa gcggggtcaa accgattggg tgggaggtcg aacgaaagat gaggaaacca       60

tttcttggga tcgcgggtgc ggcagtggtc gcgatgggcg cggtgacggc atgcggccag      120

gcgcagagcg cgccctccaa ccaggcgaac gtcggcagcg cgtcggcggc gcccattcat      180

ctgacgcttg gcatgtgggc gtcgagcccg gcggaaaagc agctcgtgga gcgtcagatt      240

gccttgtttg agaaggaaaa tccgaacatc aaggtgagca tccaggtcat cacgggcaac      300

tacctgcagg cgctgcagcc gatgctcgcc gcgcacgacg cgccggacat cttctacgtg      360

gattcgtcct acgcgccgac gctcgaggct tcgggcgcca tcatgccgct cgacagcttc      420

atcaagcagg atcatgtcga tttgtccgac ttccagaaga acctgctcga cgcgttcacc      480

tggcaggggc acatctacgg cctgccgaag gacatgaaca cgatggcctt ggagtacaac      540

ccggcgctcc tcgccaaggc gggcatccag tcgccgccga agacgttcgc gcagtttgac      600

caggaagccg cgaagctcaa ggccaagggc attgtgccgc tggacatgcc gattgacgtg      660

gcgcgctatt atccgttcat cgtcgacatg ggcgggagct actacaacaa ggccacgaac      720

caggccacct tcaccaacaa ggcgaacgtc gcgggcctca cgtggtttat gaaagagatg      780

gaaagcggca acttcgtgac cccgcaagac caaggcgggt cctgggcggg tgtcccgttc      840

gcagagggca aggcggcgat ggcccttgag ggcgcttgga ttgtgccgtt catgcagcag      900

accgcgccga agatgaagta cggcattgcg gacttcccgt cgctcaacgg gcacgatgcg      960

aacatgctgt ttacggtcgc gtacgagatg tcgaagtacg cgaagaaccc ggatgctgcc     1020

gcgaagttgc tcttcttcat gacgggcaaa gaggcgctca agatgacggc cgattcgggc     1080

ctcgccattc cctctcggac cagcgagcag ggcgagtttc tgaagaagta tccgtcgtac     1140

aagggcttcg tggacggtct caagggcgcc attccgtatc agttcggcac gctcgggcag     1200

aacttcctcg acgccatcaa caatgccacg caacaaggca ttctgaagaa ggagtcggcg     1260

cagcaagtct tgagtcaggc gcagcagacg ctcgcttcac agatgaacga ctga           1314


<210>   475
<211>   1314
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   475
atggagacaa gcggggtcaa accgattggg tgggaggtcg aacgaaagat gaggcgtcca       60

tttcttggga tcgcgggtgc ggcagtggtc gcgatgggcg cggtgacggc atgcggccag      120

gcgcagagcg cgccctccaa ccaggcgaac gtcggcagcg cgtcggcggc gcccattcat      180

ctgacgcttg gcatgtgggc gtcgagcccg gcggaaaagc agctcgtgga gcgtcagatt      240

gccttgtttg agaaggaaaa tccgaacatc aaggtgagca tccaggtcat cacgggcaac      300

tacctgcagg cgctgcagcc gatgctcgcc gcgcacgacg cgccggacat cttctacgtg      360

gattcgtcct acgcgccgac gctcgaggct tcgggcgcca tcatgccgct cgacagcttc      420

atcaagcagg atcatgtcga tttgtccgac ttccagaaga acctgctcga cgcgttcacc      480

tggcaggggc acatctacgg cctgccgaag gacatgaaca cgatggcctt ggagtacaac      540

ccggcgctcc tcgccaaggc gggcatccag tcgccgccga agacgttcgc gcagtttgac      600

caggacgccg cgaagctcaa ggccaagggc attgtgccgc tggacatgcc gattgacgtg      660

gcgcgctatt atccgttcat cgtcgacatg ggcgggagct actacaacaa ggccacgaac      720

caggccacct tcaccaacaa ggcgaacgtc gcgggcctca cgtggtttat gaaagagatg      780

gaaagcggca acttcgtgac cccgcaagac caaggcgggt cctgggcggg tgtcccgttc      840

gcagagggca aggcggcgat ggcccttgag ggcgcttgga ttgtgccgtt catgcagcag      900

accgcgccga agatgaagta cggcattgcg gacttcccgt cgctcaacgg gcacgatgcg      960

aacatgctgt ttacggtcgc gtacgagatg tcgaagtacg cgaagaaccc ggatgctgcc     1020

gcgaagttgc tcttcttcat gacgggcaaa gaggcgctca agatgacggc cgattcgggc     1080

ctcgccattc cctctcggac cagcgagcag ggcgagtttc tgaagaagta tccgtcgtac     1140

aagggcttcg tggacggtct caagggcgcc attccgtatc agttcggcac gctcgggcag     1200

aacttcctcg acgccatcaa caatgccacg caacaaggca ttctgaagaa ggagtcggcg     1260

cagcaagtct tgagtcaggc gcagcagacg ctcgcttcac agatgaacga ctga           1314


<210>   476
<211>   1314
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 461

<400>   476
atggagacaa gcggggtcaa accgattggg tgggaggtcg aacgaaagat gaggaaacca       60

tttcttggga tcgcgggtgc ggcagtggtc gcgatgggcg cggtgacggc atgcggccag      120

gcgcagagcg cgccctccaa ccaggcgaac gtcggcagcg cgtcggcggc gcccattcat      180

ctgacgcttg gcatgtgggc gtcgagcccg gcggaaaagc agctcgtgga gcgtcagatt      240

gccttgtttg agaaggaaaa tccgaactta aaggtgagca tccaggtcat cacgggcaac      300

tacctgcagg cgctgcagcc gatgctcgcc gcgcacgacg cgccggacat cttctacgtg      360

gattcgtcct acgcgccgac gctcgaggct tcgggcgcca tcatgccgct cgacagcttc      420

atcaagcagg atcatgtcga tttgtccgac ttccagaaga acctgctcga cgcgttcacc      480

tggcaggggc acatctacgg cctgccgaag gacatgaaca cgatggcctt ggagtacaac      540

ccggcgctcc tcgccaaggc gggcatccag tcgccgccga agacgttcgc gcagtttgac      600

caggacgccg cgaagctcaa ggccaagggc attgtgccgc tggacatgcc gattgacgtg      660

gcgcgctatt atccgttcat cgtcgacatg ggcgggagct actacaacaa ggccacgaac      720

caggccacct tcaccaacaa ggcgaacgtc gcgggcctca cgtggtttat gaaagagatg      780

gaaagcggca acttcgtgac cccgcaagac caaggcgggt cctgggcggg tgtcccgttc      840

gcagagggca aggcggcgat ggcccttgag ggcgcttgga ttgtgccgtt catgcagcag      900

accgcgccga agatgaagta cggcattgcg gacttcccgt cgctcaacgg gcacgatgcg      960

aacatgctgt ttacggtcgc gtacgagatg tcgaagtacg cgaagaaccc ggatgctgcc     1020

gcgaagttgc tcttcttcat gacgggcaaa gaggcgctca agatgacggc cgattcgggc     1080

ctcgccattc cctctcggac cagcgagcag ggcgagtttc tgaagaagta tccgtcgtac     1140

aagggcttcg tggacggtct caagggcgcc attccgtatc agttcggcac gctcgggcag     1200

aacttcctcg acgccatcaa caatgccacg caacaaggca ttctgaagaa ggagtcggcg     1260

cagcaagtct tgagtcaggc gcagcagacg ctcgcttcac agatgaacga ctga           1314


<210>   477
<211>   310
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   477
Met Ser Val Ala Asn Ser Ala Ala Glu Arg Val Thr Gly Arg Gly Arg 
                5                   10                  15      

Arg Ile Arg Trp Asn Val Val Glu Gln Ala Leu Ala Gly Tyr Leu Phe 
            20                  25                  30          

Ile Leu Pro Ala Ile Val Glu Leu Ala Val Phe Leu Leu Gly Pro Ile 
        35                  40                  45              

Val Tyr Ala Phe Val Ile Ser Phe Lys His Phe Ser Tyr Leu Asp Pro 
    50                  55                  60                  

Leu Asn Ser His Phe Val Gly Phe Leu Asn Tyr Ile His Leu Phe Glu 
65                  70                  75                  80  

Asp Pro Val Phe Leu Arg Ala Leu Trp Asn Thr Thr Val Tyr Ala Leu 
                85                  90                  95      

Val Val Val Pro Val Gln Thr Ala Ile Ala Met Met Leu Ala Val Ile 
            100                 105                 110         

Val Asn Arg Ile Arg Gly Lys Thr Ile Phe Arg Val Ile Tyr Tyr Leu 
        115                 120                 125             

Pro Ser Ile Thr Ser Thr Val Gly Val Ala Val Ile Phe Ser Phe Leu 
    130                 135                 140                 

Phe Gln Pro Asn Gly Leu Leu Asn Arg Leu Leu Trp Ile Leu Phe His 
145                 150                 155                 160 

Ile Gln Gly Pro Asp Tyr Phe Asn Ser Pro Ile Phe Ala Phe Pro Ala 
                165                 170                 175     

Ile Met Ala Val Ala Val Trp Thr Thr Ala Gly Gln Phe Met Val Ile 
            180                 185                 190         

Tyr Leu Ala Ala Leu Gln Glu Ile Pro Glu Glu Leu Tyr Glu Ala Ala 
        195                 200                 205             

Ala Ile Asp Gly Ala Glu Gly Phe Ala Met Leu Arg Tyr Ile Thr Ile 
    210                 215                 220                 

Pro Ser Leu Arg Arg Thr Thr Phe Leu Val Val Val Leu Gly Met Ile 
225                 230                 235                 240 

Gly Ala Phe Gln Val Phe Asp Leu Val Tyr Val Ile Ser Ser Ala Ser 
                245                 250                 255     

Ser Leu Pro Gln Gln Tyr Thr Met Thr Val Val Leu Asp Leu Phe Glu 
            260                 265                 270         

Lys Gly Phe Arg Thr Met Gln Met Gly Tyr Ala Ser Ala Met Gly Phe 
        275                 280                 285             

Val Leu Phe Ala Ile Ile Leu Val Leu Thr Leu Ile Gln Gln Leu Trp 
    290                 295                 300                 

Leu Gly Arg Glu Asp Ala 
305                 310 

<210>   478
<211>   933
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   478
atgagcgtcg caaactccgc tgccgagcgg gtcacggggc gcgggaggcg catccgatgg       60

aacgtggtgg aacaggcgct cgccggttac ctgttcattc tccccgccat cgtggagttg      120

gccgtttttc tcctggggcc catcgtgtac gcctttgtca tcagtttcaa gcacttttcg      180

tatctggatc ccctaaactc gcacttcgtg gggttcttga actacattca cctcttcgag      240

gatccggtgt ttctgcgggc gctgtggaac accacggtgt acgccctcgt ggtggtgccg      300

gtgcagactg cgatcgccat gatgctggcc gtgatcgtca accgtatccg cggaaagacg      360

atcttccggg tcatctacta cctgccgtcg atcacgtcga ccgtcggcgt ggccgtgatc      420

ttcagcttcc tgttccagcc gaacggactg ttgaaccgcc tgctgtggat cctgtttcac      480

atccaggggc ccgactactt caacagcccc atcttcgcgt ttccggccat catggcggtc      540

gccgtgtgga ccacggcagg ccagttcatg gtcatctatc tcgcggcgct gcaggagatt      600

ccggaggagc tgtacgaggc cgcggccatc gacggggcgg aagggttcgc catgttgcgc      660

tacatcacca tcccgtcgct tcggcggacc acgtttctcg tcgtggtgct cggtatgatt      720

ggcgcgttcc aggtgttcga tctcgtctac gtcatttcga gcgccagctc gcttccgcag      780

cagtacacga tgaccgttgt gctcgatctg ttcgaaaagg gcttccgcac catgcagatg      840

ggctacgcgt ccgccatggg cttcgtgctg tttgccatta ttttggtcct gacgctgatt      900

cagcagctgt ggctcggaag ggaggacgca tga                                   933


<210>   479
<211>   278
<212>   PRT
<213>   Thermoanaerobacter pseudethanolicus ATCC 33223

<400>   479
Glu Ala Leu Ser Gly Tyr Ala Phe Val Leu Pro Phe Ile Ala Ser Ile 
                5                   10                  15      

Ser Ile Phe Leu Ile Gly Pro Leu Ile Tyr Ala Phe Ile Ile Ser Phe 
            20                  25                  30          

Lys Glu Phe Ser Phe Leu Asn Pro Glu Ala Ser Arg Trp Ile Gly Phe 
        35                  40                  45              

Ala Asn Tyr Ile Lys Leu Phe Ser Asp Pro Thr Phe Lys Arg Ala Leu 
    50                  55                  60                  

Leu Asn Thr Thr Leu Tyr Ser Leu Gly Val Val Pro Thr Gln Leu Val 
65                  70                  75                  80  

Ile Ala Leu Ile Leu Ala Leu Ile Val Asn Ser Asp Ile Lys Gly Lys 
                85                  90                  95      

Thr Phe Phe Arg Val Ala Tyr Tyr Ile Pro Thr Val Thr Ser Thr Val 
            100                 105                 110         

Ala Val Ser Val Ile Phe Leu Tyr Leu Phe Lys Ala Asp Gly Leu Val 
        115                 120                 125             

Asn Ala Leu Leu Ala Lys Phe Gly Ile Gln Gly Pro Thr Trp Phe Asn 
    130                 135                 140                 

Asp Val Arg Phe Ala Leu Pro Ser Ile Met Met Met Ala Ile Trp Ser 
145                 150                 155                 160 

Ser Val Gly Asn Tyr Met Val Ile Phe Leu Ala Gly Leu Gln Asp Ile 
                165                 170                 175     

Pro Ser Glu Leu Tyr Glu Ala Ala Glu Val Asp Gly Ala Asn Lys Phe 
            180                 185                 190         

Gln Arg Phe Phe Lys Ile Thr Leu Pro Met Leu Arg Pro Ile Val Phe 
        195                 200                 205             

Phe Asn Leu Val Met Ser Leu Ile Gly Thr Phe Gln Val Phe Asp Gln 
    210                 215                 220                 

Ala Tyr Val Val Ser Gln Gly Thr Gly Gly Pro Leu Asp Ala Thr Met 
225                 230                 235                 240 

Thr Val Val Leu Asp Ile Tyr Arg Thr Gly Phe Arg Asp Phe Asn Met 
                245                 250                 255     

Gly Tyr Ala Ser Ala Met Ala Phe Val Leu Phe Val Ile Ile Leu Ile 
            260                 265                 270         

Leu Thr Leu Ile Gln Arg 
        275             

<210>   480
<211>   278
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   480
Glu Ala Leu Ser Gly Tyr Ala Phe Ala Leu Pro Phe Ile Ala Ser Ile 
                5                   10                  15      

Ser Ile Phe Leu Ile Gly Pro Leu Ile Tyr Ala Phe Ile Ile Ser Phe 
            20                  25                  30          

Lys Glu Phe Ser Phe Leu Asn Pro Glu Ala Ser Arg Trp Val Gly Phe 
        35                  40                  45              

Ala Asn Tyr Thr Lys Leu Phe Ser Asp Pro Thr Phe Lys Arg Ala Leu 
    50                  55                  60                  

Leu Asn Thr Thr Leu Tyr Ser Leu Gly Val Val Pro Thr Gln Leu Ile 
65                  70                  75                  80  

Ile Ala Leu Ile Leu Ala Leu Ile Val Asn Ser Asp Ile Lys Gly Lys 
                85                  90                  95      

Thr Phe Phe Arg Val Ala Tyr Tyr Ile Pro Thr Val Thr Ser Thr Val 
            100                 105                 110         

Ala Val Ser Val Ile Phe Leu Tyr Leu Phe Lys Ala Asp Gly Leu Val 
        115                 120                 125             

Asn Ala Leu Leu Ala Lys Phe Gly Ile Gln Gly Pro Thr Trp Phe Asn 
    130                 135                 140                 

Asp Val Arg Phe Ala Leu Pro Ser Ile Met Met Met Ala Ile Trp Ser 
145                 150                 155                 160 

Ser Val Gly Asn Tyr Met Val Ile Phe Leu Ala Gly Leu Gln Asp Ile 
                165                 170                 175     

Pro Ser Glu Leu Tyr Glu Ala Ala Glu Val Asp Gly Ala Asn Lys Phe 
            180                 185                 190         

Gln Arg Phe Phe Lys Ile Thr Leu Pro Met Leu Arg Pro Ile Val Phe 
        195                 200                 205             

Phe Asn Leu Val Met Ser Leu Ile Gly Thr Phe Gln Val Phe Asp Gln 
    210                 215                 220                 

Ala Tyr Val Val Ser Gln Gly Thr Gly Gly Pro Leu Asp Ala Thr Met 
225                 230                 235                 240 

Thr Val Val Leu Asn Ile Tyr Arg Thr Gly Phe Arg Asp Phe Asn Met 
                245                 250                 255     

Gly Tyr Ala Ser Ala Met Ala Phe Val Leu Phe Val Ile Ile Leu Ile 
            260                 265                 270         

Leu Thr Leu Ile Gln Arg 
        275             

<210>   481
<211>   286
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   481
Ile Tyr Glu Ala Leu Thr Gly Tyr Ile Phe Val Leu Pro Phe Ile Ala 
                5                   10                  15      

Ser Ile Ser Ile Phe Leu Ile Gly Pro Leu Ile Tyr Ala Phe Ile Ile 
            20                  25                  30          

Ser Phe Lys Glu Phe Ser Phe Leu Asn Pro Ala Ala Ser Lys Trp Val 
        35                  40                  45              

Gly Leu Ala Asn Tyr Ile Asn Leu Phe Ser Asp Pro Thr Phe Lys Lys 
    50                  55                  60                  

Ala Leu Leu Asn Thr Thr Leu Tyr Ser Leu Gly Val Val Pro Thr Gln 
65                  70                  75                  80  

Leu Ile Ile Ala Leu Ile Leu Ala Leu Ile Val Asn Ser Asp Ile Lys 
                85                  90                  95      

Gly Lys Thr Phe Phe Arg Val Ala Tyr Tyr Ile Pro Thr Ile Thr Ser 
            100                 105                 110         

Met Val Ala Val Ser Val Ile Phe Leu Tyr Leu Phe Lys Thr Asp Gly 
        115                 120                 125             

Leu Val Asn Met Ile Leu Ala Lys Phe Gly Ile Gln Gly Pro Thr Trp 
    130                 135                 140                 

Phe Asn Asp Val Arg Phe Ala Leu Pro Ser Ile Met Met Met Ala Val 
145                 150                 155                 160 

Trp Ser Ser Val Gly Asn Tyr Met Val Ile Phe Leu Ala Gly Leu Gln 
                165                 170                 175     

Asp Ile Pro Ala Glu Leu Tyr Glu Ala Ala Glu Val Asp Gly Ala Asn 
            180                 185                 190         

Lys Leu Gln Lys Phe Phe Asn Ile Thr Leu Pro Met Leu Arg Pro Val 
        195                 200                 205             

Val Phe Phe Asn Leu Val Ile Ser Leu Ile Gly Thr Phe Gln Val Phe 
    210                 215                 220                 

Asp Gln Ala Tyr Val Val Ser Arg Gly Thr Gly Gly Pro Leu Asp Ala 
225                 230                 235                 240 

Thr Met Thr Met Val Leu Tyr Ile Tyr Arg Thr Gly Phe Arg Asp Phe 
                245                 250                 255     

Asn Met Gly Tyr Ala Ser Ala Met Ala Phe Val Leu Phe Val Ile Ile 
            260                 265                 270         

Leu Ile Leu Thr Leu Ile Gln Arg Met Phe Phe Lys Glu Glu 
        275                 280                 285     

<210>   482
<211>   288
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   482
Leu Arg Glu Ala Gly Gln Gly Tyr Leu Phe Met Ser Pro Thr Leu Phe 
                5                   10                  15      

Val Leu Leu Thr Phe Ile Leu Gly Pro Ile Ile Tyr Ala Ile Phe Leu 
            20                  25                  30          

Ala Phe Asn Lys Val Gln Leu Leu Gly Ala Val Asn Tyr Asp Phe Val 
        35                  40                  45              

Gly Phe Gln Asn Phe Val Arg Leu Val Asp Asp Ser Arg Ala His Ile 
    50                  55                  60                  

Ala Leu Trp Asn Thr Ala Lys Tyr Val Phe Ile Val Val Pro Val Gln 
65                  70                  75                  80  

Thr Phe Leu Ala Leu Val Leu Ala Ala Ser Leu Asn Ala Gly Leu Lys 
                85                  90                  95      

Gly Glu Lys Phe Phe Arg Ile Ile Tyr Phe Leu Pro Thr Leu Thr Ser 
            100                 105                 110         

Ser Ala Val Leu Thr Leu Ile Phe Met Trp Met Tyr Asn Gln Asn Gly 
        115                 120                 125             

Leu Ile Asn Lys Ile Phe Glu Thr Val Gly Leu Pro Thr Tyr Asn Trp 
    130                 135                 140                 

Ile Gly Asp Pro Ser Ile Ala Leu Asn Ser Ile Met Ile Met Asn Ile 
145                 150                 155                 160 

Trp Ser Thr Ala Pro Phe Phe Met Val Ile Tyr Leu Ala Ala Leu Gln 
                165                 170                 175     

Gly Ile Pro Asp Ser Leu Tyr Glu Ala Ala Asp Leu Asp Gly Ala Asn 
            180                 185                 190         

Ala Ile Gln Lys Phe Phe Phe Ile Thr Val Pro Asn Leu Arg Pro Val 
        195                 200                 205             

Thr Ser Phe Val Val Ile Met Gly Ile Ile Gly Thr Phe Gln Leu Phe 
    210                 215                 220                 

Asp Gln Ser Tyr Ile Phe Ser Gly Gly Ser Gly Gly Pro Asn Asn Ser 
225                 230                 235                 240 

Thr Leu Thr Val Val Leu Leu Ile Tyr Gln Tyr Ala Phe Lys Asn Leu 
                245                 250                 255     

Gly Thr Met Gly Tyr Ala Ala Ala Leu Ala Phe Ala Leu Ala Val Ile 
            260                 265                 270         

Ile Leu Ala Ala Thr Leu Leu Gln Arg Arg Phe Ser Lys Glu Glu Asn 
        275                 280                 285             

<210>   483
<211>   286
<212>   PRT
<213>   Caldicellulosiruptor saccharolyticus DSM 8903

<400>   483
Val Gln Glu Tyr Phe Thr Ala Phe Val Met Leu Leu Pro Tyr Ile Ile 
                5                   10                  15      

Ser Phe Phe Met Phe Phe Ala Tyr Pro Leu Ala Lys Ala Phe Ile Ile 
            20                  25                  30          

Ser Phe Gln Glu Phe Ser Phe Leu Gly Asp Ile Pro Pro Lys Phe Val 
        35                  40                  45              

Gly Leu Leu Asn Tyr Lys Glu Ala Leu Thr Asn Lys Met Phe Leu Asp 
    50                  55                  60                  

Ser Ile Val Asn Thr Phe Tyr Tyr Ser Ile Leu Val Val Pro Thr Gln 
65                  70                  75                  80  

Leu Ile Ile Ala Leu Ile Leu Ala Val Ile Val Asn Asp Lys Val Lys 
                85                  90                  95      

Phe Lys Asp Phe Phe Arg Thr Thr Tyr Tyr Leu Pro Thr Val Thr Ser 
            100                 105                 110         

Pro Val Ala Val Ser Ile Ile Phe Leu Phe Leu Tyr Lys Thr Asp Gly 
        115                 120                 125             

Leu Val Asn Gln Ile Leu Ser His Ile Gly Ile Thr Pro Arg Asn Trp 
    130                 135                 140                 

Phe Asn Glu Pro Ser Phe Val Met Pro Ala Ile Val Ser Val Ala Val 
145                 150                 155                 160 

Trp Gly Ser Val Gly Phe Tyr Met Val Thr Phe Leu Ser Gly Leu Ser 
                165                 170                 175     

Thr Ile Pro Asp Gln Leu Tyr Glu Ala Ala Glu Val Glu Gly Ala Gly 
            180                 185                 190         

Glu Phe Thr Lys Leu Ile Lys Ile Thr Ile Pro Leu Leu Lys Pro Met 
        195                 200                 205             

Ile Phe Phe Asn Thr Val Val Ser Phe Ile Ser Thr Leu Gln Met Phe 
    210                 215                 220                 

Asp Leu Ser Tyr Ile Ile Gly Gly Ser Asp Gly Gly Pro Met Gly Lys 
225                 230                 235                 240 

Ala Met Thr Met Val Val Met Ile Tyr Arg Thr Ala Phe Lys Glu Phe 
                245                 250                 255     

Asn Met Gly Val Ala Ser Ala Met Ala Phe Ile Val Phe Gly Ile Ile 
            260                 265                 270         

Phe Ile Leu Thr Leu Val Gln Arg Lys Phe Phe Gly Glu Glu 
        275                 280                 285     

<210>   484
<211>   310
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   484
Met Ser Val Ala Asn Ser Ala Ala Glu Arg Ile Thr Gly Arg Gly Arg 
                5                   10                  15      

Arg Ile Arg Trp Asn Val Val Glu Gln Ala Leu Ala Gly Tyr Leu Phe 
            20                  25                  30          

Ile Leu Pro Ala Ile Val Glu Leu Ala Val Phe Leu Leu Gly Pro Ile 
        35                  40                  45              

Val Tyr Ala Phe Val Ile Ser Phe Lys His Phe Ser Tyr Leu Asp Pro 
    50                  55                  60                  

Leu Asn Ser His Phe Val Gly Phe Leu Asn Tyr Ile His Leu Phe Glu 
65                  70                  75                  80  

Asp Pro Val Phe Leu Arg Ala Leu Trp Asn Thr Thr Val Tyr Ala Leu 
                85                  90                  95      

Val Val Val Pro Val Gln Thr Ala Ile Ala Met Met Leu Ala Val Ile 
            100                 105                 110         

Val Asn Arg Ile Arg Gly Lys Thr Ile Phe Arg Val Ile Tyr Tyr Leu 
        115                 120                 125             

Pro Ser Ile Thr Ser Thr Val Gly Val Ala Val Ile Phe Ser Phe Leu 
    130                 135                 140                 

Phe Gln Pro Asn Gly Leu Leu Asn Arg Leu Leu Trp Ile Leu Phe His 
145                 150                 155                 160 

Ile Gln Gly Pro Asp Tyr Phe Asn Ser Pro Ile Phe Ala Phe Pro Ala 
                165                 170                 175     

Ile Met Ala Val Ala Val Trp Thr Thr Ala Gly Gln Phe Met Val Ile 
            180                 185                 190         

Tyr Leu Ala Ala Leu Gln Glu Ile Pro Glu Glu Leu Tyr Glu Ala Ala 
        195                 200                 205             

Ala Ile Asp Gly Ala Glu Gly Phe Ala Met Leu Arg Tyr Ile Thr Ile 
    210                 215                 220                 

Pro Ser Leu Arg Arg Thr Thr Phe Leu Val Val Val Leu Gly Met Ile 
225                 230                 235                 240 

Gly Ala Phe Gln Val Phe Asp Leu Val Tyr Val Ile Ser Ser Ala Ser 
                245                 250                 255     

Ser Leu Pro Gln Gln Tyr Thr Met Thr Val Val Leu Asp Leu Phe Glu 
            260                 265                 270         

Lys Gly Phe Arg Thr Met Gln Met Gly Tyr Ala Ser Ala Met Gly Phe 
        275                 280                 285             

Val Leu Phe Ala Ile Ile Leu Val Leu Thr Leu Ile Gln Gln Leu Trp 
    290                 295                 300                 

Leu Gly Arg Glu Asp Ala 
305                 310 

<210>   485
<211>   310
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   485
Met Ser Val Ala Asn Ser Ala Ala Glu Arg Val Thr Gly Arg Gly Arg 
                5                   10                  15      

Arg Ile Arg Trp Asn Val Ile Glu Gln Ala Leu Ala Gly Tyr Leu Phe 
            20                  25                  30          

Ile Leu Pro Ala Ile Val Glu Leu Ala Val Phe Leu Leu Gly Pro Ile 
        35                  40                  45              

Val Tyr Ala Phe Val Ile Ser Phe Lys His Phe Ser Tyr Leu Asp Pro 
    50                  55                  60                  

Leu Asn Ser His Phe Val Gly Phe Leu Asn Tyr Ile His Leu Phe Glu 
65                  70                  75                  80  

Asp Pro Val Phe Leu Arg Ala Leu Trp Asn Thr Thr Val Tyr Ala Leu 
                85                  90                  95      

Val Val Val Pro Val Gln Thr Ala Ile Ala Met Met Leu Ala Val Ile 
            100                 105                 110         

Val Asn Arg Ile Arg Gly Lys Thr Ile Phe Arg Val Ile Tyr Tyr Leu 
        115                 120                 125             

Pro Ser Ile Thr Ser Thr Val Gly Val Ala Val Ile Phe Ser Phe Leu 
    130                 135                 140                 

Phe Gln Pro Asn Gly Leu Leu Asn Arg Leu Leu Trp Ile Leu Phe His 
145                 150                 155                 160 

Ile Gln Gly Pro Asp Tyr Phe Asn Ser Pro Ile Phe Ala Phe Pro Ala 
                165                 170                 175     

Ile Met Ala Val Ala Val Trp Thr Thr Ala Gly Gln Phe Met Val Ile 
            180                 185                 190         

Tyr Leu Ala Ala Leu Gln Glu Ile Pro Glu Glu Leu Tyr Glu Ala Ala 
        195                 200                 205             

Ala Ile Asp Gly Ala Glu Gly Phe Ala Met Leu Arg Tyr Ile Thr Ile 
    210                 215                 220                 

Pro Ser Leu Arg Arg Thr Thr Phe Leu Val Val Val Leu Gly Met Ile 
225                 230                 235                 240 

Gly Ala Phe Gln Val Phe Asp Leu Val Tyr Val Ile Ser Ser Ala Ser 
                245                 250                 255     

Ser Leu Pro Gln Gln Tyr Thr Met Thr Val Val Leu Asp Leu Phe Glu 
            260                 265                 270         

Lys Gly Phe Arg Thr Met Gln Met Gly Tyr Ala Ser Ala Met Gly Phe 
        275                 280                 285             

Val Leu Phe Ala Ile Ile Leu Val Leu Thr Leu Ile Gln Gln Leu Trp 
    290                 295                 300                 

Leu Gly Arg Glu Asp Ala 
305                 310 

<210>   486
<211>   310
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   486
Met Ser Val Ala Asn Ser Ala Ala Glu Arg Val Thr Gly Arg Gly Lys 
                5                   10                  15      

Arg Ile Arg Trp Asn Val Val Glu Gln Ala Leu Ala Gly Tyr Leu Phe 
            20                  25                  30          

Ile Leu Pro Ala Ile Val Glu Leu Ala Val Phe Leu Leu Gly Pro Ile 
        35                  40                  45              

Val Tyr Ala Phe Val Ile Ser Phe Lys His Phe Ser Tyr Leu Asp Pro 
    50                  55                  60                  

Leu Asn Ser His Phe Val Gly Phe Leu Asn Tyr Ile His Leu Phe Glu 
65                  70                  75                  80  

Asp Pro Val Phe Leu Arg Ala Leu Trp Asn Thr Thr Val Tyr Ala Leu 
                85                  90                  95      

Val Val Val Pro Val Gln Thr Ala Ile Ala Met Met Leu Ala Val Ile 
            100                 105                 110         

Val Asn Arg Ile Arg Gly Lys Thr Ile Phe Arg Val Ile Tyr Tyr Leu 
        115                 120                 125             

Pro Ser Ile Thr Ser Thr Val Gly Val Ala Val Ile Phe Ser Phe Leu 
    130                 135                 140                 

Phe Gln Pro Asn Gly Leu Leu Asn Arg Leu Leu Trp Ile Leu Phe His 
145                 150                 155                 160 

Ile Gln Gly Pro Asp Tyr Phe Asn Ser Pro Ile Phe Ala Phe Pro Ala 
                165                 170                 175     

Ile Met Ala Val Ala Val Trp Thr Thr Ala Gly Gln Phe Met Val Ile 
            180                 185                 190         

Tyr Leu Ala Ala Leu Gln Glu Ile Pro Glu Glu Leu Tyr Glu Ala Ala 
        195                 200                 205             

Ala Ile Asp Gly Ala Glu Gly Phe Ala Met Leu Arg Tyr Ile Thr Ile 
    210                 215                 220                 

Pro Ser Leu Arg Arg Thr Thr Phe Leu Val Val Val Leu Gly Met Ile 
225                 230                 235                 240 

Gly Ala Phe Gln Val Phe Asp Leu Val Tyr Val Ile Ser Ser Ala Ser 
                245                 250                 255     

Ser Leu Pro Gln Gln Tyr Thr Met Thr Val Val Leu Asp Leu Phe Glu 
            260                 265                 270         

Lys Gly Phe Arg Thr Met Gln Met Gly Tyr Ala Ser Ala Met Gly Phe 
        275                 280                 285             

Val Leu Phe Ala Ile Ile Leu Val Leu Thr Leu Ile Gln Gln Leu Trp 
    290                 295                 300                 

Leu Gly Arg Glu Asp Ala 
305                 310 

<210>   487
<211>   310
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   487
Met Ser Val Ala Asn Ser Ala Ala Glu Arg Val Thr Gly Arg Gly Arg 
                5                   10                  15      

Arg Ile Arg Trp Asn Val Val Glu Gln Ala Leu Ala Gly Tyr Leu Phe 
            20                  25                  30          

Ile Leu Pro Ala Ile Val Glu Leu Ala Val Phe Leu Leu Gly Pro Ile 
        35                  40                  45              

Val Tyr Ala Phe Val Ile Ser Phe Lys His Phe Ser Tyr Leu Asp Pro 
    50                  55                  60                  

Leu Asn Ser His Phe Val Gly Phe Leu Asn Tyr Ile His Leu Phe Glu 
65                  70                  75                  80  

Asp Pro Val Phe Leu Arg Ala Leu Trp Asn Thr Thr Val Tyr Ala Leu 
                85                  90                  95      

Val Val Val Pro Val Gln Thr Ala Ile Ala Met Met Leu Ala Val Ile 
            100                 105                 110         

Val Asn Arg Ile Arg Gly Lys Thr Ile Phe Arg Val Ile Tyr Tyr Leu 
        115                 120                 125             

Pro Ser Ile Thr Ser Thr Val Gly Val Ala Val Ile Phe Ser Phe Leu 
    130                 135                 140                 

Phe Gln Pro Asn Gly Leu Leu Asn Arg Leu Leu Trp Ile Leu Phe His 
145                 150                 155                 160 

Ile Gln Gly Pro Asp Tyr Phe Asn Ser Pro Ile Phe Ala Phe Pro Ala 
                165                 170                 175     

Ile Met Ala Val Ala Val Trp Thr Thr Ala Gly Gln Phe Met Val Ile 
            180                 185                 190         

Tyr Leu Ala Ala Leu Gln Glu Ile Pro Asp Glu Leu Tyr Glu Ala Ala 
        195                 200                 205             

Ala Ile Asp Gly Ala Glu Gly Phe Ala Met Leu Arg Tyr Ile Thr Ile 
    210                 215                 220                 

Pro Ser Leu Arg Arg Thr Thr Phe Leu Val Val Val Leu Gly Met Ile 
225                 230                 235                 240 

Gly Ala Phe Gln Val Phe Asp Leu Val Tyr Val Ile Ser Ser Ala Ser 
                245                 250                 255     

Ser Leu Pro Gln Gln Tyr Thr Met Thr Val Val Leu Asp Leu Phe Glu 
            260                 265                 270         

Lys Gly Phe Arg Thr Met Gln Met Gly Tyr Ala Ser Ala Met Gly Phe 
        275                 280                 285             

Val Leu Phe Ala Ile Ile Leu Val Leu Thr Leu Ile Gln Gln Leu Trp 
    290                 295                 300                 

Leu Gly Arg Glu Asp Ala 
305                 310 

<210>   488
<211>   310
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 477

<400>   488
Met Ser Val Ala Asn Ser Ala Ala Glu Arg Val Thr Gly Arg Gly Arg 
                5                   10                  15      

Lys Ile Arg Trp Asn Val Val Glu Gln Ala Leu Ala Gly Tyr Leu Phe 
            20                  25                  30          

Ile Leu Pro Ala Ile Val Glu Leu Ala Val Phe Leu Leu Gly Pro Ile 
        35                  40                  45              

Val Tyr Ala Phe Val Ile Ser Phe Lys His Phe Ser Tyr Leu Asp Pro 
    50                  55                  60                  

Leu Asn Ser His Phe Val Gly Phe Leu Asn Tyr Ile His Leu Phe Glu 
65                  70                  75                  80  

Asp Pro Val Phe Leu Arg Ala Leu Trp Asn Thr Thr Val Tyr Ala Leu 
                85                  90                  95      

Val Val Val Pro Val Gln Thr Ala Ile Ala Met Met Leu Ala Val Ile 
            100                 105                 110         

Val Asn Arg Ile Arg Gly Lys Thr Ile Phe Arg Val Ile Tyr Tyr Leu 
        115                 120                 125             

Pro Ser Ile Thr Ser Thr Val Gly Val Ala Val Ile Phe Ser Phe Leu 
    130                 135                 140                 

Phe Gln Pro Asn Gly Leu Leu Asn Arg Leu Leu Trp Ile Leu Phe His 
145                 150                 155                 160 

Ile Gln Gly Pro Asp Tyr Phe Asn Ser Pro Ile Phe Ala Phe Pro Ala 
                165                 170                 175     

Ile Met Ala Val Ala Val Trp Thr Thr Ala Gly Gln Phe Met Val Ile 
            180                 185                 190         

Tyr Leu Ala Ala Leu Gln Glu Ile Pro Glu Glu Leu Tyr Glu Ala Ala 
        195                 200                 205             

Ala Ile Asp Gly Ala Glu Gly Phe Ala Met Leu Arg Tyr Ile Thr Ile 
    210                 215                 220                 

Pro Ser Leu Arg Arg Thr Thr Phe Leu Val Val Val Leu Gly Met Ile 
225                 230                 235                 240 

Gly Ala Phe Gln Val Phe Asp Leu Val Tyr Val Ile Ser Ser Ala Ser 
                245                 250                 255     

Ser Leu Pro Gln Gln Tyr Thr Met Thr Val Val Leu Asp Leu Phe Glu 
            260                 265                 270         

Lys Gly Phe Arg Thr Met Gln Met Gly Tyr Ala Ser Ala Met Gly Phe 
        275                 280                 285             

Val Leu Phe Ala Ile Ile Leu Val Leu Thr Leu Ile Gln Gln Leu Trp 
    290                 295                 300                 

Leu Gly Arg Glu Asp Ala 
305                 310 

<210>   489
<211>   933
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   489
atgagcgtcg caaactccgc tgccgagcgg attacggggc gcgggaggcg catccgatgg       60

aacgtggtgg aacaggcgct cgccggttac ctgttcattc tccccgccat cgtggagttg      120

gccgtttttc tcctggggcc catcgtgtac gcctttgtca tcagtttcaa gcacttttcg      180

tatctggatc ccctaaactc gcacttcgtg gggttcttga actacattca cctcttcgag      240

gatccggtgt ttctgcgggc gctgtggaac accacggtgt acgccctcgt ggtggtgccg      300

gtgcagactg cgatcgccat gatgctggcc gtgatcgtca accgtatccg cggaaagacg      360

atcttccggg tcatctacta cctgccgtcg atcacgtcga ccgtcggcgt ggccgtgatc      420

ttcagcttcc tgttccagcc gaacggactg ttgaaccgcc tgctgtggat cctgtttcac      480

atccaggggc ccgactactt caacagcccc atcttcgcgt ttccggccat catggcggtc      540

gccgtgtgga ccacggcagg ccagttcatg gtcatctatc tcgcggcgct gcaggagatt      600

ccggaggagc tgtacgaggc cgcggccatc gacggggcgg aagggttcgc catgttgcgc      660

tacatcacca tcccgtcgct tcggcggacc acgtttctcg tcgtggtgct cggtatgatt      720

ggcgcgttcc aggtgttcga tctcgtctac gtcatttcga gcgccagctc gcttccgcag      780

cagtacacga tgaccgttgt gctcgatctg ttcgaaaagg gcttccgcac catgcagatg      840

ggctacgcgt ccgccatggg cttcgtgctg tttgccatta ttttggtcct gacgctgatt      900

cagcagctgt ggctcggaag ggaggacgca tga                                   933


<210>   490
<211>   933
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   490
atgagcgtcg caaactccgc tgccgagcgg gtcacggggc gcgggaggcg catccgatgg       60

aacgtgattg aacaggcgct cgccggttac ctgttcattc tccccgccat cgtggagttg      120

gccgtttttc tcctggggcc catcgtgtac gcctttgtca tcagtttcaa gcacttttcg      180

tatctggatc ccctaaactc gcacttcgtg gggttcttga actacattca cctcttcgag      240

gatccggtgt ttctgcgggc gctgtggaac accacggtgt acgccctcgt ggtggtgccg      300

gtgcagactg cgatcgccat gatgctggcc gtgatcgtca accgtatccg cggaaagacg      360

atcttccggg tcatctacta cctgccgtcg atcacgtcga ccgtcggcgt ggccgtgatc      420

ttcagcttcc tgttccagcc gaacggactg ttgaaccgcc tgctgtggat cctgtttcac      480

atccaggggc ccgactactt caacagcccc atcttcgcgt ttccggccat catggcggtc      540

gccgtgtgga ccacggcagg ccagttcatg gtcatctatc tcgcggcgct gcaggagatt      600

ccggaggagc tgtacgaggc cgcggccatc gacggggcgg aagggttcgc catgttgcgc      660

tacatcacca tcccgtcgct tcggcggacc acgtttctcg tcgtggtgct cggtatgatt      720

ggcgcgttcc aggtgttcga tctcgtctac gtcatttcga gcgccagctc gcttccgcag      780

cagtacacga tgaccgttgt gctcgatctg ttcgaaaagg gcttccgcac catgcagatg      840

ggctacgcgt ccgccatggg cttcgtgctg tttgccatta ttttggtcct gacgctgatt      900

cagcagctgt ggctcggaag ggaggacgca tga                                   933


<210>   491
<211>   933
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   491
atgagcgtcg caaactccgc tgccgagcgg gtcacggggc gcgggaaacg catccgatgg       60

aacgtggtgg aacaggcgct cgccggttac ctgttcattc tccccgccat cgtggagttg      120

gccgtttttc tcctggggcc catcgtgtac gcctttgtca tcagtttcaa gcacttttcg      180

tatctggatc ccctaaactc gcacttcgtg gggttcttga actacattca cctcttcgag      240

gatccggtgt ttctgcgggc gctgtggaac accacggtgt acgccctcgt ggtggtgccg      300

gtgcagactg cgatcgccat gatgctggcc gtgatcgtca accgtatccg cggaaagacg      360

atcttccggg tcatctacta cctgccgtcg atcacgtcga ccgtcggcgt ggccgtgatc      420

ttcagcttcc tgttccagcc gaacggactg ttgaaccgcc tgctgtggat cctgtttcac      480

atccaggggc ccgactactt caacagcccc atcttcgcgt ttccggccat catggcggtc      540

gccgtgtgga ccacggcagg ccagttcatg gtcatctatc tcgcggcgct gcaggagatt      600

ccggaggagc tgtacgaggc cgcggccatc gacggggcgg aagggttcgc catgttgcgc      660

tacatcacca tcccgtcgct tcggcggacc acgtttctcg tcgtggtgct cggtatgatt      720

ggcgcgttcc aggtgttcga tctcgtctac gtcatttcga gcgccagctc gcttccgcag      780

cagtacacga tgaccgttgt gctcgatctg ttcgaaaagg gcttccgcac catgcagatg      840

ggctacgcgt ccgccatggg cttcgtgctg tttgccatta ttttggtcct gacgctgatt      900

cagcagctgt ggctcggaag ggaggacgca tga                                   933


<210>   492
<211>   933
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   492
atgagcgtcg caaactccgc tgccgagcgg gtcacggggc gcgggaggcg catccgatgg       60

aacgtggtgg aacaggcgct cgccggttac ctgttcattc tccccgccat cgtggagttg      120

gccgtttttc tcctggggcc catcgtgtac gcctttgtca tcagtttcaa gcacttttcg      180

tatctggatc ccctaaactc gcacttcgtg gggttcttga actacattca cctcttcgag      240

gatccggtgt ttctgcgggc gctgtggaac accacggtgt acgccctcgt ggtggtgccg      300

gtgcagactg cgatcgccat gatgctggcc gtgatcgtca accgtatccg cggaaagacg      360

atcttccggg tcatctacta cctgccgtcg atcacgtcga ccgtcggcgt ggccgtgatc      420

ttcagcttcc tgttccagcc gaacggactg ttgaaccgcc tgctgtggat cctgtttcac      480

atccaggggc ccgactactt caacagcccc atcttcgcgt ttccggccat catggcggtc      540

gccgtgtgga ccacggcagg ccagttcatg gtcatctatc tcgcggcgct gcaggagatt      600

ccggatgagc tgtacgaggc cgcggccatc gacggggcgg aagggttcgc catgttgcgc      660

tacatcacca tcccgtcgct tcggcggacc acgtttctcg tcgtggtgct cggtatgatt      720

ggcgcgttcc aggtgttcga tctcgtctac gtcatttcga gcgccagctc gcttccgcag      780

cagtacacga tgaccgttgt gctcgatctg ttcgaaaagg gcttccgcac catgcagatg      840

ggctacgcgt ccgccatggg cttcgtgctg tttgccatta ttttggtcct gacgctgatt      900

cagcagctgt ggctcggaag ggaggacgca tga                                   933


<210>   493
<211>   933
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 478

<400>   493
atgagcgtcg caaactccgc tgccgagcgg gtcacggggc gcgggaggaa aatccgatgg       60

aacgtggtgg aacaggcgct cgccggttac ctgttcattc tccccgccat cgtggagttg      120

gccgtttttc tcctggggcc catcgtgtac gcctttgtca tcagtttcaa gcacttttcg      180

tatctggatc ccctaaactc gcacttcgtg gggttcttga actacattca cctcttcgag      240

gatccggtgt ttctgcgggc gctgtggaac accacggtgt acgccctcgt ggtggtgccg      300

gtgcagactg cgatcgccat gatgctggcc gtgatcgtca accgtatccg cggaaagacg      360

atcttccggg tcatctacta cctgccgtcg atcacgtcga ccgtcggcgt ggccgtgatc      420

ttcagcttcc tgttccagcc gaacggactg ttgaaccgcc tgctgtggat cctgtttcac      480

atccaggggc ccgactactt caacagcccc atcttcgcgt ttccggccat catggcggtc      540

gccgtgtgga ccacggcagg ccagttcatg gtcatctatc tcgcggcgct gcaggagatt      600

ccggaggagc tgtacgaggc cgcggccatc gacggggcgg aagggttcgc catgttgcgc      660

tacatcacca tcccgtcgct tcggcggacc acgtttctcg tcgtggtgct cggtatgatt      720

ggcgcgttcc aggtgttcga tctcgtctac gtcatttcga gcgccagctc gcttccgcag      780

cagtacacga tgaccgttgt gctcgatctg ttcgaaaagg gcttccgcac catgcagatg      840

ggctacgcgt ccgccatggg cttcgtgctg tttgccatta ttttggtcct gacgctgatt      900

cagcagctgt ggctcggaag ggaggacgca tga                                   933


<210>   494
<211>   280
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   494
Met Arg Met Ala Thr Ser Ala Pro Ser Pro Ser Trp Arg Arg Ala Gly 
                5                   10                  15      

Leu Trp Met Tyr Val Ile Ala Val Ile Tyr Ala Ala Ile Ser Leu Val 
            20                  25                  30          

Pro Phe Leu Trp Ser Ile Tyr Thr Ser Val Lys Pro Thr Ser Glu Val 
        35                  40                  45              

Phe Gln Leu Phe Val Pro Trp Arg Thr Leu Thr Leu Ser Ser Tyr Thr 
    50                  55                  60                  

Ser Ile Leu Gln Asn Phe Pro Phe Gly Arg Trp Phe Leu Asn Ser Ala 
65                  70                  75                  80  

Ile Val Ala Phe Ile Val Thr Val Gly Asn Leu Val Val Asn Thr Phe 
                85                  90                  95      

Ala Gly Tyr Ala Phe Ala Arg Leu Arg Phe Pro Gly Arg Gly Phe Leu 
            100                 105                 110         

Phe Tyr Val Phe Leu Gly Val Met Met Ile Pro Gly Gln Val Val Leu 
        115                 120                 125             

Val Pro Ile Tyr Met Leu Leu Ala Arg Leu Gly Trp Ile Asp Thr Tyr 
    130                 135                 140                 

Val Gly Leu Thr Val Pro Phe Leu Leu Ser Ser Thr Met Val Phe Leu 
145                 150                 155                 160 

Ser Arg Gln Phe Phe Leu Gly Ile Pro Lys Glu Leu Glu Glu Ala Ala 
                165                 170                 175     

Arg Ile Asp Gly Ile Gly Tyr Phe Gly Met Phe Phe Arg Ile Met Leu 
            180                 185                 190         

Pro Leu Ala Arg Pro Leu Leu Ala Ala Gln Thr Ile Leu Thr Phe Gln 
        195                 200                 205             

Gly Asn Trp Asn Ser Phe Leu Trp Pro Leu Leu Ile Gly Gln Thr Thr 
    210                 215                 220                 

Asn Met Tyr Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr 
225                 230                 235                 240 

Asn Ala Tyr Trp Asn Ser Val Met Ala Gly Met Val Leu Leu Thr Val 
                245                 250                 255     

Pro Met Met Val Val Phe Ile Ile Phe Gln Arg Gln Phe Ile Gln Gly 
            260                 265                 270         

Val Ser Gln Ala Gly Leu Lys Gly 
        275                 280 

<210>   495
<211>   843
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   495
atgcgcatgg ccacatccgc accatccccg tcctggcgcc gcgccggcct gtggatgtac       60

gtgattgccg tgatctacgc ggccatttcg ctggtgccct ttctgtggtc catctacacg      120

tcggtcaagc cgacgtccga ggtgtttcaa ctcttcgtgc cctggcggac cctgacgctg      180

tcgagctaca cctccatcct gcagaacttc ccgtttgggc gctggttttt gaacagcgcc      240

atcgtggcgt tcatcgtgac cgtgggaaac ctggtggtga acacgtttgc gggctacgcg      300

tttgcgcggc ttcgtttccc gggccggggc tttttgtttt acgtcttcct cggcgtcatg      360

atgatcccag gacaggtggt cttggttccc atttacatgc tgctcgcgcg cctcggctgg      420

atcgacacct acgtcgggct caccgtgccg ttcttgctga gttccaccat ggtgtttttg      480

tcgcgccagt ttttcctcgg catcccgaag gagctggagg aggcggctcg catcgacggc      540

atcggatact tcgggatgtt ctttcgcatc atgctgccgc tcgcgcgtcc gctcctggcc      600

gcgcagacca ttctgacgtt ccagggcaac tggaactcgt ttctctggcc gcttctcatc      660

ggtcagacga cgaacatgta cacgttgccg gtggggctga actcgtttta tggccagtac      720

aacgcgtact ggaacagcgt gatggcgggc atggtcctgc tgacggttcc catgatggtt      780

gtgttcatca tctttcagcg ccaattcatt cagggcgtgt cccaagcagg actcaaaggc      840

tga                                                                    843


<210>   496
<211>   260
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   496
Tyr Met Val Leu Ile Gly Tyr Ala Ala Ile Thr Leu Gly Pro Phe Ile 
                5                   10                  15      

Trp Ser Ile Ile Thr Ser Leu Lys Pro Thr Ser Glu Leu Asn Thr Phe 
            20                  25                  30          

Ala Val Asn Ile Lys His Leu Thr Leu Asp Asn Tyr Lys Met Ile Ile 
        35                  40                  45              

Thr Lys Phe Pro Phe Leu Arg Trp Phe Ile Asn Ser Ala Ile Val Ala 
    50                  55                  60                  

Ala Ile Val Thr Phe Gly Asn Met Leu Phe Asn Ser Met Ala Gly Tyr 
65                  70                  75                  80  

Ala Leu Ala Arg Ile Asn Phe Pro Gly Arg Asn Phe Leu Phe Leu Leu 
                85                  90                  95      

Val Leu Ala Leu Met Met Ile Pro Gly Gln Val Val Met Val Pro Thr 
            100                 105                 110         

Tyr Ile Leu Leu Ser Lys Leu Gly Trp Val Asn Thr Tyr Met Gly Leu 
        115                 120                 125             

Thr Ile Pro Phe Leu Thr Ser Asn Phe Gly Ile Phe Leu Met Arg Gln 
    130                 135                 140                 

Phe Phe Leu Thr Ile Pro Arg Glu Leu Glu Glu Ala Ala Thr Ile Asp 
145                 150                 155                 160 

Gly Met Ser Arg Phe Gly Ile Phe Phe Lys Ile Val Leu Pro Leu Ala 
                165                 170                 175     

Lys Pro Ala Leu Ala Thr Gln Phe Ile Phe Met Phe Thr Gly Asn Trp 
            180                 185                 190         

Asn Ser Phe Leu Trp Pro Ser Leu Leu Thr Ser Ser Asp Asp Met Tyr 
        195                 200                 205             

Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr Tyr Gln Phe 
    210                 215                 220                 

Trp Asn Gln Val Met Ala Gly Ala Ile Leu Leu Thr Leu Pro Thr Ile 
225                 230                 235                 240 

Val Ile Phe Leu Ile Phe Gln Arg Tyr Phe Val Arg Gly Ile Ala Thr 
                245                 250                 255     

Thr Gly Leu Lys 
            260 

<210>   497
<211>   260
<212>   PRT
<213>   Thermoanaerobacter pseudethanolicus ATCC 33223

<400>   497
Tyr Thr Val Val Val Gly Tyr Ala Val Ile Thr Leu Gly Pro Phe Ile 
                5                   10                  15      

Trp Ser Ile Ile Thr Ser Leu Lys Pro Thr Ser Glu Leu Asn Thr Phe 
            20                  25                  30          

Ala Val Asn Ile Lys His Leu Thr Leu Asp Asn Tyr Lys Met Ile Ile 
        35                  40                  45              

Thr Lys Phe Pro Phe Leu Arg Trp Phe Ile Asn Ser Ala Ile Val Ala 
    50                  55                  60                  

Val Ile Val Thr Leu Gly Asn Ile Leu Phe Asn Ser Met Ala Gly Tyr 
65                  70                  75                  80  

Ala Leu Ala Arg Ile Asn Phe Pro Gly Arg Asn Leu Leu Phe Met Val 
                85                  90                  95      

Val Leu Ala Leu Met Met Val Pro Gly Gln Val Val Met Val Pro Thr 
            100                 105                 110         

Tyr Ile Leu Leu Ser Lys Leu Gly Trp Val Asn Thr Tyr Met Gly Leu 
        115                 120                 125             

Thr Ile Pro Phe Leu Thr Ser Asn Phe Gly Ile Phe Leu Met Arg Gln 
    130                 135                 140                 

Phe Phe Leu Ser Leu Pro Lys Glu Leu Glu Glu Ala Ala Thr Ile Asp 
145                 150                 155                 160 

Gly Leu Ser Arg Phe Gly Ile Phe Phe Lys Ile Val Leu Pro Leu Ser 
                165                 170                 175     

Lys Pro Ala Leu Ala Thr Gln Phe Ile Phe Met Phe Thr Gly Asn Trp 
            180                 185                 190         

Asn Ser Phe Leu Trp Pro Ser Leu Leu Thr Ser Ser Asp Asp Met Tyr 
        195                 200                 205             

Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr Tyr Gln Phe 
    210                 215                 220                 

Trp Asn Gln Val Met Ala Gly Ala Ile Leu Leu Thr Leu Pro Thr Ile 
225                 230                 235                 240 

Leu Ile Phe Leu Ile Phe Gln Arg Tyr Phe Val Lys Gly Ile Ser Thr 
                245                 250                 255     

Thr Gly Leu Lys 
            260 

<210>   498
<211>   260
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   498
Tyr Thr Val Val Val Gly Tyr Ala Val Ile Thr Leu Gly Pro Phe Ile 
                5                   10                  15      

Trp Ser Ile Ile Thr Ser Leu Lys Pro Thr Ser Glu Leu Asn Thr Phe 
            20                  25                  30          

Val Val Asn Ile Lys His Leu Thr Leu Asp Asn Tyr Lys Met Ile Ile 
        35                  40                  45              

Thr Lys Phe Pro Phe Leu Arg Trp Phe Ile Asn Ser Ala Ile Val Ala 
    50                  55                  60                  

Ala Ile Val Thr Phe Gly Asn Met Leu Phe Asn Ser Met Ala Gly Tyr 
65                  70                  75                  80  

Ala Leu Ala Arg Ile Asn Phe Pro Gly Arg Asn Leu Leu Phe Met Val 
                85                  90                  95      

Val Leu Ala Leu Met Met Val Pro Gly Gln Val Val Met Val Pro Thr 
            100                 105                 110         

Tyr Ile Leu Leu Ser Lys Leu Gly Trp Val Asn Thr Tyr Met Gly Leu 
        115                 120                 125             

Thr Ile Pro Phe Leu Thr Ser Asn Phe Gly Ile Phe Leu Met Arg Gln 
    130                 135                 140                 

Phe Phe Leu Ser Leu Pro Lys Glu Leu Glu Glu Ala Ala Thr Ile Asp 
145                 150                 155                 160 

Gly Leu Ser Arg Phe Gly Ile Phe Phe Lys Ile Val Leu Pro Leu Ser 
                165                 170                 175     

Lys Pro Ala Leu Ala Thr Gln Phe Ile Phe Met Phe Thr Gly Asn Trp 
            180                 185                 190         

Asn Ser Phe Leu Trp Pro Ser Leu Leu Thr Ser Ser Asp Asp Met Tyr 
        195                 200                 205             

Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr Tyr Gln Phe 
    210                 215                 220                 

Trp Asn Gln Val Met Ala Gly Ala Ile Leu Leu Thr Leu Pro Thr Ile 
225                 230                 235                 240 

Leu Ile Phe Leu Ile Phe Gln Arg Tyr Phe Val Lys Gly Ile Ser Thr 
                245                 250                 255     

Thr Gly Leu Lys 
            260 

<210>   499
<211>   260
<212>   PRT
<213>   Caldicellulosiruptor saccharolyticus DSM 8903

<400>   499
Tyr Ser Ile Cys Ile Leu Trp Thr Leu Val Thr Leu Ile Pro Tyr Leu 
                5                   10                  15      

Ile Ala Val Ile Thr Ser Leu Lys Pro Val Glu Asp Val Thr Lys Phe 
            20                  25                  30          

Ser Ile Asp Phe Ser Lys Leu Thr Phe Asp Ser Tyr Arg Tyr Ile Thr 
        35                  40                  45              

His Glu Phe Pro Phe Leu Arg Trp Leu Phe Asn Ser Phe Val Val Ala 
    50                  55                  60                  

Val Ala Val Thr Thr Gly Asn Ile Leu Phe Asn Ser Met Ala Ala Tyr 
65                  70                  75                  80  

Ala Leu Ala Arg Leu Asp Phe Pro Phe Lys Lys Val Val Phe Tyr Val 
                85                  90                  95      

Ile Ile Gly Thr Met Met Ile Pro Gly Gln Val Leu Leu Ile Pro Ile 
            100                 105                 110         

Tyr Leu Ile Leu Asn Arg Leu Gly Trp Ile Asp Ser Tyr Lys Gly Leu 
        115                 120                 125             

Ile Ile Pro Trp Leu Val Ser Ala Phe Tyr Ile Phe Phe Met Arg Gln 
    130                 135                 140                 

Tyr Phe Leu Thr Ile Pro Lys Asp Leu Glu Glu Ala Ala Leu Ile Asp 
145                 150                 155                 160 

Gly Leu Ser Arg Phe Gly Ile Phe Phe Lys Ile Phe Leu Pro Leu Ser 
                165                 170                 175     

Leu Pro Ala Leu Ala Thr Gln Ala Ile Phe Ile Phe Val Gly Asn Trp 
            180                 185                 190         

Asn Ser Phe Met Trp Pro Ser Ile Ile Ala Ser Ser Glu Asp Leu Tyr 
        195                 200                 205             

Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr Tyr Gln Phe 
    210                 215                 220                 

Trp Asn Gln Val Leu Ala Gly Ala Ile Leu Leu Ser Leu Pro Thr Ile 
225                 230                 235                 240 

Ile Val Phe Val Leu Phe Gln Lys Tyr Phe Val Lys Gly Ile Val Thr 
                245                 250                 255     

Ser Gly Leu Lys 
            260 

<210>   500
<211>   264
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   500
Leu Tyr Val Val Leu Val Met Tyr Ala Ile Ile Thr Leu Ile Pro Phe 
                5                   10                  15      

Leu Trp Ala Leu Ser Ser Ser Phe Lys Thr Leu Glu Glu Ile Val Ser 
            20                  25                  30          

Gly Thr Met Ser Phe Val Pro Lys Gln Phe Thr Leu Asp Asn Tyr Lys 
        35                  40                  45              

Gln Ile Phe Val Glu Gln Asp Leu Phe Pro Arg Trp Leu Leu Asn Ser 
    50                  55                  60                  

Val Ile Ile Ala Val Ala Val Thr Ile Leu Asn Leu Leu Phe Asn Ser 
65                  70                  75                  80  

Met Ala Gly Tyr Ala Leu Ala Arg Leu Gln Phe Pro Gly Arg Lys Pro 
                85                  90                  95      

Leu Phe Leu Ile Ile Leu Ala Val Leu Met Ile Pro Ala Gln Val Thr 
            100                 105                 110         

Met Ile Pro Asn Tyr Leu Ile Leu Lys Gln Leu Gly Trp Leu Asn Ser 
        115                 120                 125             

Tyr Gln Gly Met Ile Val Pro Thr Met Ile Asn Ala Thr Phe Ile Phe 
    130                 135                 140                 

Met Met Arg Gln Phe Phe Ile Asn Phe Pro Lys Glu Leu Glu Glu Ala 
145                 150                 155                 160 

Ala Glu Leu Asp Gly Leu Gly Arg Phe Gly Ile Phe Phe Arg Ile Val 
                165                 170                 175     

Leu Pro Leu Ala Arg Pro Ala Leu Ala Ala Gln Ala Ile Phe Val Phe 
            180                 185                 190         

Met Gly Ser Trp Asn Asp Phe Met Arg Pro Leu Ile Ile Leu Ser Asp 
        195                 200                 205             

Pro Gln Leu Phe Thr Leu Pro Leu Gly Leu Asn Ser Phe Lys Gly Gln 
    210                 215                 220                 

Tyr Ile Ser Tyr Trp Asn Tyr Ile Met Ala Ala Ser Met Val Phe Thr 
225                 230                 235                 240 

Leu Pro Val Leu Val Ile Tyr Ala Phe Phe Asn Arg Tyr Phe Ile Lys 
                245                 250                 255     

Gly Ile Ser Phe Thr Gly Gly Lys 
            260                 

<210>   501
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   501
Met Arg Met Ala Thr Ser Ala Pro Ser Pro Ser Trp Arg Arg Ala Gly 
                5                   10                  15      

Leu Trp Met Tyr Val Ile Ala Val Ile Tyr Ala Ala Ile Ser Leu Val 
            20                  25                  30          

Pro Phe Leu Trp Ser Ile Tyr Thr Ser Val Lys Pro Thr Ser Glu Val 
        35                  40                  45              

Phe Gln Leu Phe Val Pro Trp Arg Thr Leu Thr Leu Ser Ser Tyr Thr 
    50                  55                  60                  

Ser Ile Leu Gln Asn Phe Pro Phe Gly Arg Trp Phe Leu Asn Ser Ala 
65                  70                  75                  80  

Ile Val Ala Phe Ile Val Thr Val Gly Asn Leu Val Val Asn Thr Phe 
                85                  90                  95      

Ala Gly Tyr Ala Phe Ala Arg Leu Lys Phe Pro Gly Arg Gly Phe Leu 
            100                 105                 110         

Phe Tyr Val Phe Leu Gly Val Met Met Ile Pro Gly Gln Val Val Leu 
        115                 120                 125             

Val Pro Ile Tyr Met Leu Leu Ala Arg Leu Gly Trp Ile Asp Thr Tyr 
    130                 135                 140                 

Val Gly Leu Thr Val Pro Phe Leu Leu Ser Ser Thr Met Val Phe Leu 
145                 150                 155                 160 

Ser Arg Gln Phe Phe Leu Gly Ile Pro Lys Glu Leu Glu Glu Ala Ala 
                165                 170                 175     

Arg Ile Asp Gly Ile Gly Tyr Phe Gly Met Phe Phe Arg Ile Met Leu 
            180                 185                 190         

Pro Leu Ala Arg Pro Leu Leu Ala Ala Gln Thr Ile Leu Thr Phe Gln 
        195                 200                 205             

Gly Asn Trp Asn Ser Phe Leu Trp Pro Leu Leu Ile Gly Gln Thr Thr 
    210                 215                 220                 

Asn Met Tyr Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr 
225                 230                 235                 240 

Asn Ala Tyr Trp Asn Ser Val Met Ala Gly Met Val Leu Leu Thr Val 
                245                 250                 255     

Pro Met Met Val Val Phe Ile Ile Phe Gln Arg Gln Phe Ile Gln Gly 
            260                 265                 270         

Val Ser Gln Ala Gly Leu Lys Gly 
        275                 280 

<210>   502
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   502
Met Arg Met Ala Thr Ser Ala Pro Ser Pro Ser Trp Arg Arg Ala Gly 
                5                   10                  15      

Leu Trp Met Tyr Val Ile Ala Val Ile Tyr Ala Ala Ile Ser Leu Val 
            20                  25                  30          

Pro Phe Leu Trp Ser Ile Tyr Thr Ser Val Lys Pro Thr Ser Glu Val 
        35                  40                  45              

Phe Gln Leu Phe Val Pro Trp Arg Thr Leu Thr Ile Ser Ser Tyr Thr 
    50                  55                  60                  

Ser Ile Leu Gln Asn Phe Pro Phe Gly Arg Trp Phe Leu Asn Ser Ala 
65                  70                  75                  80  

Ile Val Ala Phe Ile Val Thr Val Gly Asn Leu Val Val Asn Thr Phe 
                85                  90                  95      

Ala Gly Tyr Ala Phe Ala Arg Leu Arg Phe Pro Gly Arg Gly Phe Leu 
            100                 105                 110         

Phe Tyr Val Phe Leu Gly Val Met Met Ile Pro Gly Gln Val Val Leu 
        115                 120                 125             

Val Pro Ile Tyr Met Leu Leu Ala Arg Leu Gly Trp Ile Asp Thr Tyr 
    130                 135                 140                 

Val Gly Leu Thr Val Pro Phe Leu Leu Ser Ser Thr Met Val Phe Leu 
145                 150                 155                 160 

Ser Arg Gln Phe Phe Leu Gly Ile Pro Lys Glu Leu Glu Glu Ala Ala 
                165                 170                 175     

Arg Ile Asp Gly Ile Gly Tyr Phe Gly Met Phe Phe Arg Ile Met Leu 
            180                 185                 190         

Pro Leu Ala Arg Pro Leu Leu Ala Ala Gln Thr Ile Leu Thr Phe Gln 
        195                 200                 205             

Gly Asn Trp Asn Ser Phe Leu Trp Pro Leu Leu Ile Gly Gln Thr Thr 
    210                 215                 220                 

Asn Met Tyr Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr 
225                 230                 235                 240 

Asn Ala Tyr Trp Asn Ser Val Met Ala Gly Met Val Leu Leu Thr Val 
                245                 250                 255     

Pro Met Met Val Val Phe Ile Ile Phe Gln Arg Gln Phe Ile Gln Gly 
            260                 265                 270         

Val Ser Gln Ala Gly Leu Lys Gly 
        275                 280 

<210>   503
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   503
Met Arg Met Ala Thr Ser Ala Pro Ser Pro Ser Trp Arg Arg Ala Gly 
                5                   10                  15      

Leu Trp Met Tyr Val Ile Ala Val Ile Tyr Ala Ala Ile Ser Leu Val 
            20                  25                  30          

Pro Phe Leu Trp Ser Ile Tyr Thr Ser Val Lys Pro Thr Ser Glu Val 
        35                  40                  45              

Phe Gln Leu Phe Val Pro Trp Arg Thr Leu Thr Leu Ser Ser Tyr Thr 
    50                  55                  60                  

Ser Ile Leu Gln Asn Phe Pro Phe Gly Arg Trp Phe Leu Asn Ser Ala 
65                  70                  75                  80  

Ile Val Ala Phe Ile Val Thr Val Gly Asn Leu Val Val Asn Thr Phe 
                85                  90                  95      

Ala Gly Tyr Ala Phe Ala Arg Leu Arg Phe Pro Gly Arg Gly Phe Leu 
            100                 105                 110         

Phe Tyr Val Phe Leu Gly Val Met Met Ile Pro Gly Gln Val Val Leu 
        115                 120                 125             

Val Pro Ile Tyr Met Ile Leu Ala Arg Leu Gly Trp Ile Asp Thr Tyr 
    130                 135                 140                 

Val Gly Leu Thr Val Pro Phe Leu Leu Ser Ser Thr Met Val Phe Leu 
145                 150                 155                 160 

Ser Arg Gln Phe Phe Leu Gly Ile Pro Lys Glu Leu Glu Glu Ala Ala 
                165                 170                 175     

Arg Ile Asp Gly Ile Gly Tyr Phe Gly Met Phe Phe Arg Ile Met Leu 
            180                 185                 190         

Pro Leu Ala Arg Pro Leu Leu Ala Ala Gln Thr Ile Leu Thr Phe Gln 
        195                 200                 205             

Gly Asn Trp Asn Ser Phe Leu Trp Pro Leu Leu Ile Gly Gln Thr Thr 
    210                 215                 220                 

Asn Met Tyr Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr 
225                 230                 235                 240 

Asn Ala Tyr Trp Asn Ser Val Met Ala Gly Met Val Leu Leu Thr Val 
                245                 250                 255     

Pro Met Met Val Val Phe Ile Ile Phe Gln Arg Gln Phe Ile Gln Gly 
            260                 265                 270         

Val Ser Gln Ala Gly Leu Lys Gly 
        275                 280 

<210>   504
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   504
Met Arg Met Ala Thr Ser Ala Pro Ser Pro Ser Trp Arg Arg Ala Gly 
                5                   10                  15      

Leu Trp Met Tyr Val Ile Ala Val Ile Tyr Ala Ala Ile Ser Leu Val 
            20                  25                  30          

Pro Phe Leu Trp Ser Ile Tyr Thr Ser Val Lys Pro Thr Ser Glu Val 
        35                  40                  45              

Phe Gln Leu Phe Val Pro Trp Arg Thr Leu Thr Leu Ser Ser Tyr Thr 
    50                  55                  60                  

Ser Ile Leu Gln Asn Phe Pro Phe Gly Arg Trp Phe Leu Asn Ser Ala 
65                  70                  75                  80  

Ile Val Ala Phe Ile Val Thr Val Gly Asn Leu Val Val Asn Thr Phe 
                85                  90                  95      

Ala Gly Tyr Ala Phe Ala Arg Leu Arg Phe Pro Gly Arg Gly Phe Leu 
            100                 105                 110         

Phe Tyr Val Phe Leu Gly Val Met Met Ile Pro Gly Gln Val Val Leu 
        115                 120                 125             

Val Pro Leu Tyr Met Leu Leu Ala Arg Leu Gly Trp Ile Asp Thr Tyr 
    130                 135                 140                 

Val Gly Leu Thr Val Pro Phe Leu Leu Ser Ser Thr Met Val Phe Leu 
145                 150                 155                 160 

Ser Arg Gln Phe Phe Leu Gly Ile Pro Lys Glu Leu Glu Glu Ala Ala 
                165                 170                 175     

Arg Ile Asp Gly Ile Gly Tyr Phe Gly Met Phe Phe Arg Ile Met Leu 
            180                 185                 190         

Pro Leu Ala Arg Pro Leu Leu Ala Ala Gln Thr Ile Leu Thr Phe Gln 
        195                 200                 205             

Gly Asn Trp Asn Ser Phe Leu Trp Pro Leu Leu Ile Gly Gln Thr Thr 
    210                 215                 220                 

Asn Met Tyr Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr 
225                 230                 235                 240 

Asn Ala Tyr Trp Asn Ser Val Met Ala Gly Met Val Leu Leu Thr Val 
                245                 250                 255     

Pro Met Met Val Val Phe Ile Ile Phe Gln Arg Gln Phe Ile Gln Gly 
            260                 265                 270         

Val Ser Gln Ala Gly Leu Lys Gly 
        275                 280 

<210>   505
<211>   280
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 494

<400>   505
Met Arg Met Ala Thr Ser Ala Pro Ser Pro Ser Trp Arg Arg Ala Gly 
                5                   10                  15      

Leu Trp Met Tyr Val Ile Ala Val Ile Tyr Ala Ala Ile Ser Leu Val 
            20                  25                  30          

Pro Phe Ile Trp Ser Ile Tyr Thr Ser Val Lys Pro Thr Ser Glu Val 
        35                  40                  45              

Phe Gln Leu Phe Val Pro Trp Arg Thr Leu Thr Leu Ser Ser Tyr Thr 
    50                  55                  60                  

Ser Ile Leu Gln Asn Phe Pro Phe Gly Arg Trp Phe Leu Asn Ser Ala 
65                  70                  75                  80  

Ile Val Ala Phe Ile Val Thr Val Gly Asn Leu Val Val Asn Thr Phe 
                85                  90                  95      

Ala Gly Tyr Ala Phe Ala Arg Leu Arg Phe Pro Gly Arg Gly Phe Leu 
            100                 105                 110         

Phe Tyr Val Phe Leu Gly Val Met Met Ile Pro Gly Gln Val Val Leu 
        115                 120                 125             

Val Pro Ile Tyr Met Leu Leu Ala Arg Leu Gly Trp Ile Asp Thr Tyr 
    130                 135                 140                 

Val Gly Leu Thr Val Pro Phe Leu Leu Ser Ser Thr Met Val Phe Leu 
145                 150                 155                 160 

Ser Arg Gln Phe Phe Leu Gly Ile Pro Lys Glu Leu Glu Glu Ala Ala 
                165                 170                 175     

Arg Ile Asp Gly Ile Gly Tyr Phe Gly Met Phe Phe Arg Ile Met Leu 
            180                 185                 190         

Pro Leu Ala Arg Pro Leu Leu Ala Ala Gln Thr Ile Leu Thr Phe Gln 
        195                 200                 205             

Gly Asn Trp Asn Ser Phe Leu Trp Pro Leu Leu Ile Gly Gln Thr Thr 
    210                 215                 220                 

Asn Met Tyr Thr Leu Pro Val Gly Leu Asn Ser Phe Tyr Gly Gln Tyr 
225                 230                 235                 240 

Asn Ala Tyr Trp Asn Ser Val Met Ala Gly Met Val Leu Leu Thr Val 
                245                 250                 255     

Pro Met Met Val Val Phe Ile Ile Phe Gln Arg Gln Phe Ile Gln Gly 
            260                 265                 270         

Val Ser Gln Ala Gly Leu Lys Gly 
        275                 280 

<210>   506
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   506
atgcgcatgg ccacatccgc accatccccg tcctggcgcc gcgccggcct gtggatgtac       60

gtgattgccg tgatctacgc ggccatttcg ctggtgccct ttctgtggtc catctacacg      120

tcggtcaagc cgacgtccga ggtgtttcaa ctcttcgtgc cctggcggac cctgacgctg      180

tcgagctaca cctccatcct gcagaacttc ccgtttgggc gctggttttt gaacagcgcc      240

atcgtggcgt tcatcgtgac cgtgggaaac ctggtggtga acacgtttgc gggctacgcg      300

tttgcgcggc ttaaattccc gggccggggc tttttgtttt acgtcttcct cggcgtcatg      360

atgatcccag gacaggtggt cttggttccc atttacatgc tgctcgcgcg cctcggctgg      420

atcgacacct acgtcgggct caccgtgccg ttcttgctga gttccaccat ggtgtttttg      480

tcgcgccagt ttttcctcgg catcccgaag gagctggagg aggcggctcg catcgacggc      540

atcggatact tcgggatgtt ctttcgcatc atgctgccgc tcgcgcgtcc gctcctggcc      600

gcgcagacca ttctgacgtt ccagggcaac tggaactcgt ttctctggcc gcttctcatc      660

ggtcagacga cgaacatgta cacgttgccg gtggggctga actcgtttta tggccagtac      720

aacgcgtact ggaacagcgt gatggcgggc atggtcctgc tgacggttcc catgatggtt      780

gtgttcatca tctttcagcg ccaattcatt cagggcgtgt cccaagcagg actcaaaggc      840

tga                                                                    843


<210>   507
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   507
atgcgcatgg ccacatccgc accatccccg tcctggcgcc gcgccggcct gtggatgtac       60

gtgattgccg tgatctacgc ggccatttcg ctggtgccct ttctgtggtc catctacacg      120

tcggtcaagc cgacgtccga ggtgtttcaa ctcttcgtgc cctggcggac cctgacgatt      180

tcgagctaca cctccatcct gcagaacttc ccgtttgggc gctggttttt gaacagcgcc      240

atcgtggcgt tcatcgtgac cgtgggaaac ctggtggtga acacgtttgc gggctacgcg      300

tttgcgcggc ttcgtttccc gggccggggc tttttgtttt acgtcttcct cggcgtcatg      360

atgatcccag gacaggtggt cttggttccc atttacatgc tgctcgcgcg cctcggctgg      420

atcgacacct acgtcgggct caccgtgccg ttcttgctga gttccaccat ggtgtttttg      480

tcgcgccagt ttttcctcgg catcccgaag gagctggagg aggcggctcg catcgacggc      540

atcggatact tcgggatgtt ctttcgcatc atgctgccgc tcgcgcgtcc gctcctggcc      600

gcgcagacca ttctgacgtt ccagggcaac tggaactcgt ttctctggcc gcttctcatc      660

ggtcagacga cgaacatgta cacgttgccg gtggggctga actcgtttta tggccagtac      720

aacgcgtact ggaacagcgt gatggcgggc atggtcctgc tgacggttcc catgatggtt      780

gtgttcatca tctttcagcg ccaattcatt cagggcgtgt cccaagcagg actcaaaggc      840

tga                                                                    843


<210>   508
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   508
atgcgcatgg ccacatccgc accatccccg tcctggcgcc gcgccggcct gtggatgtac       60

gtgattgccg tgatctacgc ggccatttcg ctggtgccct ttctgtggtc catctacacg      120

tcggtcaagc cgacgtccga ggtgtttcaa ctcttcgtgc cctggcggac cctgacgctg      180

tcgagctaca cctccatcct gcagaacttc ccgtttgggc gctggttttt gaacagcgcc      240

atcgtggcgt tcatcgtgac cgtgggaaac ctggtggtga acacgtttgc gggctacgcg      300

tttgcgcggc ttcgtttccc gggccggggc tttttgtttt acgtcttcct cggcgtcatg      360

atgatcccag gacaggtggt cttggttccc atttacatga ttctcgcgcg cctcggctgg      420

atcgacacct acgtcgggct caccgtgccg ttcttgctga gttccaccat ggtgtttttg      480

tcgcgccagt ttttcctcgg catcccgaag gagctggagg aggcggctcg catcgacggc      540

atcggatact tcgggatgtt ctttcgcatc atgctgccgc tcgcgcgtcc gctcctggcc      600

gcgcagacca ttctgacgtt ccagggcaac tggaactcgt ttctctggcc gcttctcatc      660

ggtcagacga cgaacatgta cacgttgccg gtggggctga actcgtttta tggccagtac      720

aacgcgtact ggaacagcgt gatggcgggc atggtcctgc tgacggttcc catgatggtt      780

gtgttcatca tctttcagcg ccaattcatt cagggcgtgt cccaagcagg actcaaaggc      840

tga                                                                    843


<210>   509
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   509
atgcgcatgg ccacatccgc accatccccg tcctggcgcc gcgccggcct gtggatgtac       60

gtgattgccg tgatctacgc ggccatttcg ctggtgccct ttctgtggtc catctacacg      120

tcggtcaagc cgacgtccga ggtgtttcaa ctcttcgtgc cctggcggac cctgacgctg      180

tcgagctaca cctccatcct gcagaacttc ccgtttgggc gctggttttt gaacagcgcc      240

atcgtggcgt tcatcgtgac cgtgggaaac ctggtggtga acacgtttgc gggctacgcg      300

tttgcgcggc ttcgtttccc gggccggggc tttttgtttt acgtcttcct cggcgtcatg      360

atgatcccag gacaggtggt cttggttccc ttatacatgc tgctcgcgcg cctcggctgg      420

atcgacacct acgtcgggct caccgtgccg ttcttgctga gttccaccat ggtgtttttg      480

tcgcgccagt ttttcctcgg catcccgaag gagctggagg aggcggctcg catcgacggc      540

atcggatact tcgggatgtt ctttcgcatc atgctgccgc tcgcgcgtcc gctcctggcc      600

gcgcagacca ttctgacgtt ccagggcaac tggaactcgt ttctctggcc gcttctcatc      660

ggtcagacga cgaacatgta cacgttgccg gtggggctga actcgtttta tggccagtac      720

aacgcgtact ggaacagcgt gatggcgggc atggtcctgc tgacggttcc catgatggtt      780

gtgttcatca tctttcagcg ccaattcatt cagggcgtgt cccaagcagg actcaaaggc      840

tga                                                                    843


<210>   510
<211>   843
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 495

<400>   510
atgcgcatgg ccacatccgc accatccccg tcctggcgcc gcgccggcct gtggatgtac       60

gtgattgccg tgatctacgc ggccatttcg ctggtgccct ttatttggtc catctacacg      120

tcggtcaagc cgacgtccga ggtgtttcaa ctcttcgtgc cctggcggac cctgacgctg      180

tcgagctaca cctccatcct gcagaacttc ccgtttgggc gctggttttt gaacagcgcc      240

atcgtggcgt tcatcgtgac cgtgggaaac ctggtggtga acacgtttgc gggctacgcg      300

tttgcgcggc ttcgtttccc gggccggggc tttttgtttt acgtcttcct cggcgtcatg      360

atgatcccag gacaggtggt cttggttccc atttacatgc tgctcgcgcg cctcggctgg      420

atcgacacct acgtcgggct caccgtgccg ttcttgctga gttccaccat ggtgtttttg      480

tcgcgccagt ttttcctcgg catcccgaag gagctggagg aggcggctcg catcgacggc      540

atcggatact tcgggatgtt ctttcgcatc atgctgccgc tcgcgcgtcc gctcctggcc      600

gcgcagacca ttctgacgtt ccagggcaac tggaactcgt ttctctggcc gcttctcatc      660

ggtcagacga cgaacatgta cacgttgccg gtggggctga actcgtttta tggccagtac      720

aacgcgtact ggaacagcgt gatggcgggc atggtcctgc tgacggttcc catgatggtt      780

gtgttcatca tctttcagcg ccaattcatt cagggcgtgt cccaagcagg actcaaaggc      840

tga                                                                    843


<210>   511
<211>   576
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   511
Met Gln Lys Gly Glu Arg Asn Met Lys Arg Ser Lys Ser Asn Arg Gly 
                5                   10                  15      

Trp Val Ala Ala Ala Val Gly Leu Ala Val Val Gly Val Ala Gly Cys 
            20                  25                  30          

Gly Ala Ala Asn Thr Ser Ala Asn Gly Ala Ser His Ser Ala Ser Ala 
        35                  40                  45              

Ser Pro Glu Ala Ala Ser Ala Ser Ser Ser Ser Val Leu Thr Val Ala 
    50                  55                  60                  

Pro Asn Val Thr Gly Thr Phe Ser Asp Asn Phe Asn Pro Phe Ser Thr 
65                  70                  75                  80  

Asn Ser Met Pro Gly Thr Leu Gly Asn Ile Tyr Glu Thr Leu Phe Tyr 
                85                  90                  95      

Phe Asp Asn Thr Thr Gly Lys Gln Phe Asn Leu Leu Gly Thr Ser Phe 
            100                 105                 110         

His Phe Ser Asn Gly Gly Lys Ile Leu Thr Val Ser Leu Arg Lys Asn 
        115                 120                 125             

Ala Val Trp Thr Asp Gly Val Pro Phe Thr Ala Gln Asp Val Val Phe 
    130                 135                 140                 

Thr Phe Glu Asp Leu Lys Lys Tyr Pro Asp Ala Asp Thr Asn Gly Val 
145                 150                 155                 160 

Trp Gln Gln Leu Lys Ser Val Gln Ala Asp Gly Lys Tyr Thr Val Val 
                165                 170                 175     

Phe Gln Phe Ala Gln Pro Asn Ile Pro Phe Ala Glu Gln Tyr Val Leu 
            180                 185                 190         

Gly Gly Thr Tyr Ile Val Pro Ala His Gln Trp Lys Ser Leu Gly Asp 
        195                 200                 205             

Pro Ala Lys Ala Lys Ile Thr His Leu Asn Ala Ile Gly Thr Gly Pro 
    210                 215                 220                 

Phe Lys Leu Ser Ser Phe Thr Thr Gln Asp Tyr Gln Phe Thr Ala Asn 
225                 230                 235                 240 

Pro Arg Tyr Tyr Gly Gly Ala Pro Glu Val Lys Thr Leu Asn Tyr Pro 
                245                 250                 255     

Ala Phe Ala Ser Asn Ser Ser Ala Asp Leu Ala Leu Ala Ser Gly Gln 
            260                 265                 270         

Ile Gln Tyr Ala Gly Ile Asn Ile Pro Asn Val Glu Lys Thr Phe Val 
        275                 280                 285             

Ala Ala Asp Pro Ala His Asn His Tyr Leu Phe Pro Pro Asn Glu Ser 
    290                 295                 300                 

Val Glu Leu Tyr Pro Asn Leu His Asn Ser Leu Leu Ala Met Leu Pro 
305                 310                 315                 320 

Val Arg Glu Ala Ile Ser Leu Ala Ile Asp Arg Asp Ala Leu Ser Lys 
                325                 330                 335     

Ile Gly Glu Thr Gly Tyr Glu Lys Pro Ala Val Pro Thr Ser Leu Val 
            340                 345                 350         

Leu Pro Pro Gln Ser Ser Trp Leu Asp Pro Ser Leu Pro Ala Ser Asp 
        355                 360                 365             

Arg Ala Phe Ala Val Asn Asp Ala Lys Ala Val Gln Ile Leu Gln Lys 
    370                 375                 380                 

Ala Gly Phe Arg Lys Asp Gln Asn Gly Ile Phe Ala Leu His Gly Lys 
385                 390                 395                 400 

Glu Leu Ser Phe Asn Leu Leu Thr Val Ser Gly Trp Ser Asp Trp Asp 
                405                 410                 415     

Glu Asp Ala Leu Leu Ile Lys Gln Gln Leu Ala Lys Val Gly Ile Ala 
            420                 425                 430         

Val Asn Val Gln Glu Glu Gln Phe Ser Ala Tyr Tyr Ser Ala Ile Asp 
        435                 440                 445             

Pro Gly Pro Gly Gln Thr Pro His Tyr Asp Leu Ala Ile Ser Trp Thr 
    450                 455                 460                 

Asn Val Gly Pro Thr Pro Tyr Thr Thr Tyr Tyr Asp Met Leu Asp Ser 
465                 470                 475                 480 

His Gly Ser Phe Asn Leu Glu Gly Tyr Arg Asn Ala Gln Val Asp Gln 
                485                 490                 495     

Trp Phe Asn Glu Phe Ser Ser Thr Thr Asp Ser Gln Val Gln His Gln 
            500                 505                 510         

Val Met Tyr Arg Ile Glu Arg Leu Val Ala Ser Gln Leu Pro Val Ile 
        515                 520                 525             

Pro Leu Leu Asp Gly Ala Leu Trp Tyr Glu Tyr Asn Asp Ser His Phe 
    530                 535                 540                 

Thr Gly Phe Pro Thr Ala Asn Asn Leu Trp Ile Asn Pro Ala Pro Tyr 
545                 550                 555                 560 

Thr Tyr Gln Ala Ala Ala Ile Ile Met Asp His Leu Lys Pro Val Lys 
                565                 570                 575     

<210>   512
<211>   1731
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   512
gtgcaaaagg gggaacgaaa catgaagcgg tcgaagagca atcgaggatg ggtcgccgct       60

gcggtcggtc tcgccgtggt gggtgtcgcc gggtgcggcg cagcgaacac ctcggcgaac      120

ggcgccagcc attctgcctc ggcgtcgcca gaggcggcga gcgcgtcgtc gagttcggtc      180

ctgaccgtcg cgccgaacgt cacgggcacc ttttcggaca acttcaatcc gtttagcacc      240

aacagcatgc ccggcaccct aggcaacatc tacgagacat tgttctactt cgacaatacg      300

acagggaaac agttcaacct gttggggacc tccttccact tttcgaacgg agggaaaatc      360

ctgacggttt ctctgcgaaa aaacgcggtc tggacggacg gagtcccgtt cacggcgcag      420

gatgttgtct tcacgttcga ggatctcaag aagtatcccg acgcggatac caacggcgtg      480

tggcagcagc tgaagagcgt ccaggccgac ggaaagtaca ccgtggtctt ccagttcgcg      540

cagcccaaca tcccgtttgc cgagcagtac gtccttgggg gcacgtacat tgtgccggct      600

catcagtgga agtcgcttgg cgatccggcc aaggccaaga tcacgcactt gaacgccatt      660

ggcacgggtc cattcaagct gtcgtccttt acaactcagg actaccaatt caccgcaaat      720

ccgcgttact acggaggggc acctgaggtc aagaccctca attatccggc gttcgccagc      780

aactcgagtg ccgatttggc gctcgcgagc ggtcagattc aatacgccgg catcaacatt      840

cccaatgtcg agaagacctt cgtggcagcc gatccggcgc acaaccacta tttgttcccg      900

cccaacgaat cggtggagct ctatccgaac ctgcacaact cgctgctcgc catgctgcct      960

gtgcgcgagg ccatcagcct ggccatcgat cgcgacgcac tctccaaaat cggagagacg     1020

ggctatgaga agccagccgt gccgacgagt ctcgtcttac cgccacagtc gtcgtggttg     1080

gacccgagtc tgcccgcgag cgatcgcgcc tttgcggtca acgatgccaa agcggttcag     1140

attttgcaga aggcaggctt ccgcaaggac caaaacggga tttttgcgct ccatggcaag     1200

gagttgtcct tcaacttact cacggtaagc ggttggagcg actgggatga ggacgcgctg     1260

ctcatcaagc agcagttggc gaaggtcggg atcgccgtga atgtccagga ggagcagttc     1320

tcggcctact acagcgctat cgatccgggc ccgggccaga cgccgcacta cgacctcgcc     1380

atctcgtgga ccaacgtggg gcctacgccg tacacgacgt attacgacat gttggattcg     1440

cacggatcct ttaatttgga aggctatcgc aatgcgcagg tggatcagtg gttcaacgag     1500

ttttcgtcga ccacggatag ccaggttcag caccaggtga tgtacaggat tgagcgactc     1560

gtggcgagcc aactgccggt catcccgctg ttggatggcg cgctctggta cgagtacaac     1620

gacagccact tcacgggctt cccgacggcc aacaacctct ggatcaatcc ggcgccgtac     1680

acctaccagg cggctgccat catcatggat cacctgaagc cggtgaagtg a              1731


<210>   513
<211>   517
<212>   PRT
<213>   Sorangium cellulosum 'So ce 56'

<400>   513
Leu Thr Val Ser Ile Glu Gln Gln Ala Ser Trp Val Arg Asn Phe Asn 
                5                   10                  15      

Pro Leu Leu Ala Pro Gly Asn Val Arg Trp Pro Thr Val Ala Gly Ile 
            20                  25                  30          

Tyr Glu Pro Leu Leu Val Tyr Asn Thr Met Lys Gly Glu Phe Thr Pro 
        35                  40                  45              

Trp Leu Ala Ser Lys Tyr Glu Trp Gly Asn Gly Asn Lys Thr Leu Thr 
    50                  55                  60                  

Val Thr Thr Arg Pro Gly Val Lys Trp Ser Asp Gly Gln Pro Phe Thr 
65                  70                  75                  80  

Ala Lys Asp Val Ala Phe Thr Phe Gly Leu Leu Lys Lys His Val Ala 
                85                  90                  95      

Leu Asp Leu Gln Gly Val Trp Lys Trp Leu Thr Ser Val Glu Ala Lys 
            100                 105                 110         

Ser Asp Ser Thr Val Glu Phe Thr Leu Thr Arg Pro Tyr Val Pro Gly 
        115                 120                 125             

Leu Val Phe Leu Gly His Gln Pro Ile Val Pro Glu His Lys Trp Lys 
    130                 135                 140                 

Asp Val Ala Asp Pro Val Thr Tyr Thr Asn Glu Asn Pro Val Ala Thr 
145                 150                 155                 160 

Gly Pro Phe Thr Glu Val Lys Thr Phe Gln Asn Gln Ile Tyr Glu Leu 
                165                 170                 175     

Gly Arg Asn Pro Asn Tyr Trp Gln Gln Gly Lys Pro Ala Ile Lys Gly 
            180                 185                 190         

Leu Arg Phe Pro Ala Tyr Pro Gly Asn Asp Gln Ala Asn Leu Ala Leu 
        195                 200                 205             

Leu Asn Gly Glu Val Asp Trp Ala Gly Asn Phe Val Pro Glu Ile Glu 
    210                 215                 220                 

Lys Val Tyr Val Gly Lys Asp Pro Ala Asn His His Tyr Trp Phe Pro 
225                 230                 235                 240 

Leu Val Gly Ser Thr Val Phe Val Tyr Thr Asn Thr Thr Lys Lys Pro 
                245                 250                 255     

Leu Asp Asp Ala Arg Val Arg Lys Ala Ile Ser Met Ser Leu Asp Arg 
            260                 265                 270         

Glu Gln Ile Val Lys Val Ala Met Asn Asn Tyr Thr Arg Pro Ala Asp 
        275                 280                 285             

Ala Thr Ala Leu Ser Asp Ala His Glu Arg Trp Arg Ser Gln Lys Thr 
    290                 295                 300                 

Val Glu Ala Gly Asp Trp Val Lys Phe Asn Val Ala Lys Ala Asn Gln 
305                 310                 315                 320 

Ile Leu Asp Glu Ala Gly Tyr Ala Lys Gly Ala Asp Gly Ile Arg Val 
                325                 330                 335     

Lys Asp Gly Lys Pro Leu Arg Phe Asp Leu Asn Val Val Thr Gly Trp 
            340                 345                 350         

Ser Asp Trp Val Arg Ala Ala Gln Ile Val Thr Gln Gln Val Lys Gln 
        355                 360                 365             

Ile Gly Val Glu Ala Thr Leu Lys Thr Tyr Asp Phe Ser Ala Phe Phe 
    370                 375                 380                 

Glu Ala Leu Gln Lys Gly Thr Phe Asp Leu Ser Met Gly Trp Ser Asn 
385                 390                 395                 400 

Glu Glu Pro Thr Pro Tyr Asn Phe Tyr Arg Asp Leu Leu Gly Thr Ala 
                405                 410                 415     

Thr Ala Lys Pro Val Gly Glu Thr Ser Ala Arg Asn Trp His Arg Phe 
            420                 425                 430         

Gly Ala Lys Gln Ala Asp Gly Leu Phe Glu Ala Phe Glu Ala Ala Thr 
        435                 440                 445             

Glu Pro Ala Glu Gln Lys Lys Leu Ile Glu Gln Leu Gln Glu Ile Phe 
    450                 455                 460                 

Ser Glu Thr Ala Pro Ser Ile Pro Leu Phe Pro Gly Pro Ser Trp Gly 
465                 470                 475                 480 

Glu Tyr Asn Thr Arg Arg Phe Thr Gly Phe Pro Ser Lys Glu Asn Pro 
                485                 490                 495     

Tyr Ala Lys Leu Ser Pro Asn Asn Pro Pro Glu Tyr Leu Leu Val Leu 
            500                 505                 510         

Thr Glu Leu Lys Pro 
        515         

<210>   514
<211>   518
<212>   PRT
<213>   Sorangium cellulosum 'So ce 56'

<400>   514
Met Val Thr Ile Ser Arg Glu Gln Gln Ala Ser Trp Val Arg Ser Phe 
                5                   10                  15      

Asn Pro Leu Leu Ala Glu Gly Ser Val Arg Phe Pro Thr Leu Ala Gly 
            20                  25                  30          

Ile Tyr Glu Pro Met Leu Ile Phe Asn Thr Met Lys Gly Glu Tyr Thr 
        35                  40                  45              

Pro Trp Leu Ala Thr Lys Tyr Ala Trp Ser Asp Gly Asn Lys Lys Leu 
    50                  55                  60                  

Thr Phe Thr Thr Arg Ser Gly Val Gln Trp Ser Asp Gly Gln Ala Phe 
65                  70                  75                  80  

Ser Ala Lys Asp Val Val Phe Thr Phe Glu Leu Leu Lys Lys His Ala 
                85                  90                  95      

Ala Leu Asp Leu Ser Gly Val Trp Lys Phe Val Glu Ser Val Lys Ala 
            100                 105                 110         

Thr Asp Asp Ala Thr Val Glu Phe Ala Leu Lys Arg Pro Tyr Val Pro 
        115                 120                 125             

Gly Leu Ser Tyr Ile Gly His Gln Pro Ile Val Pro Glu His Lys Trp 
    130                 135                 140                 

Lys Asp Val Ala Asp Pro Val Thr Tyr Ala Asn Glu Asn Pro Val Ala 
145                 150                 155                 160 

Thr Gly Pro Phe Thr Glu Ile Lys Thr Phe Gln Asn Gln Val Tyr Glu 
                165                 170                 175     

Leu Gly Arg Asn Pro Asn Tyr Trp Gln Lys Gly Lys Pro Ala Val Asp 
            180                 185                 190         

Gly Leu Arg Phe Pro Ala Tyr Pro Gly Asn Asp Gln Val Asn Leu Ala 
        195                 200                 205             

Ile Ile Asn Gly Glu Val Asp Trp Ala Gly Ala Phe Val Pro Glu Ile 
    210                 215                 220                 

Glu Lys Val Tyr Val Ala Lys Asp Pro Ala Asn His His Tyr Trp Phe 
225                 230                 235                 240 

Pro Leu Val Gly Gly Met Ala Thr Leu Tyr Pro Asn Ser Thr Lys Lys 
                245                 250                 255     

Pro Phe Asp Asp Val Arg Val Arg Lys Ala Ile Ser Met Gly Ile Asp 
            260                 265                 270         

Arg Ala Gln Ile Val Lys Ile Ala Ser Asn Asp Tyr Thr Gln Pro Ala 
        275                 280                 285             

Asp Ala Thr Gly Leu Asp Asp Ser Tyr Glu Arg Trp Arg Asn Pro Lys 
    290                 295                 300                 

Ala Val Ala Ala Gly Asp Trp Val Lys Leu Asp Val Ala Arg Ala Lys 
305                 310                 315                 320 

Gln Leu Leu Asp Glu Ala Gly Tyr Ala Pro Gly Pro Asp Gly Ile Arg 
                325                 330                 335     

Val Lys Asp Gly Lys Pro Met Arg Phe Glu Ile Asn Val Val Thr Gly 
            340                 345                 350         

Trp Ser Asp Trp Val Arg Ala Val Gln Ile Met Thr Gln Asn Leu Lys 
        355                 360                 365             

Gln Leu Gly Ile Asp Ala Ser Leu Lys Ala Tyr Asp Phe Ser Ala Phe 
    370                 375                 380                 

Phe Glu Ala Leu Gln Lys Gly Thr Phe Asp Met Ser Met Gly Trp Thr 
385                 390                 395                 400 

Thr Val Glu Pro Thr Pro Tyr Asn Tyr Tyr Arg Asp Leu Met Ser Ala 
                405                 410                 415     

Glu Leu Val Lys Pro Val Gly Glu Ala Ser Ala Arg Asn Trp His Arg 
            420                 425                 430         

Tyr Gly Asp Lys Glu Ala Asp Lys Leu Phe Gln Gln Phe Glu Ala Ala 
        435                 440                 445             

Thr Glu Ser Ala Glu Gln Lys Arg Ile Leu Asp Glu Val Gln Met Leu 
    450                 455                 460                 

Tyr Ala Gln Asn Ala Pro Val Ile Pro Leu Phe Lys Asn Pro Ser Trp 
465                 470                 475                 480 

Gly Glu Tyr Ser Thr Lys Arg Phe Thr Gly Phe Pro Thr Lys Glu Asn 
                485                 490                 495     

Pro Tyr Ala Lys Leu Ser Pro Asn Asn Pro Pro Glu Tyr Leu Leu Val 
            500                 505                 510         

Leu Thr Glu Ile Arg Pro 
        515             

<210>   515
<211>   517
<212>   PRT
<213>   Sorangium cellulosum 'So ce 56'

<400>   515
Val Thr Ile Ser Arg Glu Gln Gln Ala Ser Trp Val Arg Asn Phe Asn 
                5                   10                  15      

Pro Leu Leu Gly Glu Gly Ala Thr Arg Phe Pro Thr Val Ala Gly Ile 
            20                  25                  30          

Tyr Glu Pro Met Ile Val Tyr Asn Thr Met Lys Gly Glu Tyr Val Pro 
        35                  40                  45              

Trp Leu Ala Thr Lys Tyr Glu Trp Ser Asp Ala Asn Lys Lys Leu Thr 
    50                  55                  60                  

Phe Thr Thr Arg Thr Glu Val Lys Trp Ser Asp Gly Gln Pro Phe Ser 
65                  70                  75                  80  

Ala Lys Asp Val Ala Phe Thr Phe Gly Leu Leu Lys Lys Phe Pro Ala 
                85                  90                  95      

Leu Asp Leu Thr Gly Val Trp Lys Leu Val Asp Ser Val Glu Ala Lys 
            100                 105                 110         

Asn Asp Thr Thr Val Glu Phe Val Phe Lys Glu Ala Phe Val Pro Gly 
        115                 120                 125             

Leu Thr Tyr Ile Gly His Gln Pro Ile Val Pro Glu His Lys Trp Lys 
    130                 135                 140                 

Asp Val Ala Asp Pro Val Thr Phe Thr Asn Glu Asn Pro Val Ala Thr 
145                 150                 155                 160 

Gly Pro Phe Thr Glu Val Lys Thr Phe Gln Asn Gln Ile Tyr Glu Leu 
                165                 170                 175     

Gly Lys Asn Pro Asn Tyr Trp Gln Lys Gly Lys Pro Ala Val Glu Gly 
            180                 185                 190         

Leu Arg Phe Pro Ala Tyr Pro Gly Asn Asp Gln Ala Asn Leu Ala Leu 
        195                 200                 205             

Ile Asn Gly Glu Val Asp Trp Ala Gly Asn Phe Val Pro Asp Ile Asp 
    210                 215                 220                 

Lys Thr Tyr Val Ala Lys Asp Pro Glu Asn Asn His Tyr Trp Phe Pro 
225                 230                 235                 240 

Leu Val Gly Gly Thr Val Thr Leu Tyr Pro Asn Ala Thr Lys Lys Pro 
                245                 250                 255     

Phe Asn Asp Ile Lys Leu Arg Lys Ala Ile Ser Met Ala Ile Asp Arg 
            260                 265                 270         

Ala Gln Ile Ala Lys Val Ala Val Asn Gly Tyr Thr Val Gly Ala Asp 
        275                 280                 285             

Gly Thr Gly Leu Asp Asp Ala Tyr Gly Arg Trp Arg Ser Asp Lys Ala 
    290                 295                 300                 

Ala Ala Ala Gly Asp Trp Thr Thr Phe Asp Val Ala Lys Ala Asn Ala 
305                 310                 315                 320 

Leu Leu Asp Glu Ala Gly Tyr Ala Lys Gly Ala Asp Gly Ile Arg Ala 
                325                 330                 335     

Lys Asp Gly Lys Pro Leu Lys Phe Asp Ile Asn Val Val Thr Gly Trp 
            340                 345                 350         

Ser Asp Trp Val Arg Ala Val Gln Ile Thr Thr Gln Ser Leu Lys Ala 
        355                 360                 365             

Val Gly Ile Glu Ala Thr Leu Lys Thr Tyr Asp Phe Ser Ala Phe Phe 
    370                 375                 380                 

Glu Ala Leu Gln Lys Gly Thr Phe Asp Met Ser Met Gly Trp Thr Asn 
385                 390                 395                 400 

Thr Glu Pro Thr Pro Phe Asn Tyr Tyr Arg Asp Leu Met Ala Pro Glu 
                405                 410                 415     

Phe Val Lys Ala Val Gly Glu Val Ser Asn Arg Asn Trp His Arg Phe 
            420                 425                 430         

Ala Ala Lys Glu Ala Glu Pro Leu Phe Lys Lys Phe Ala Ala Ala Thr 
        435                 440                 445             

Asp Pro Ala Glu Gln Lys Ser Ile Val Glu Asp Leu Gln Met Ile Tyr 
    450                 455                 460                 

Ala Thr Gln Val Pro Val Ile Pro Leu Phe Lys Asn Pro Ser Trp Gly 
465                 470                 475                 480 

Glu Tyr Ser Thr Lys Arg Phe Val Gly Trp Pro Ser Lys Glu Asn Pro 
                485                 490                 495     

Tyr Ala Lys Leu Ser Pro Asn Asn Ser Pro Asp Tyr Leu Leu Val Leu 
            500                 505                 510         

Thr Glu Ile Lys Pro 
        515         

<210>   516
<211>   504
<212>   PRT
<213>   Thermotoga lettingae TMO

<400>   516
Leu Thr Met Ile Ile Ser Val Thr Gly Ala His Gln Arg Asn Phe Asn 
                5                   10                  15      

Pro Tyr Phe Ala Gly Gly Thr Gly Tyr Ala Ala Cys Gly Phe Ile Tyr 
            20                  25                  30          

Glu Thr Leu Ile Tyr Ser Asn Asn Phe Thr Gly Glu Ile Ile Pro Trp 
        35                  40                  45              

Leu Ala Val Asp Tyr Glu Trp Ser Asn Asp Tyr Arg Ser Ile Val Phe 
    50                  55                  60                  

Asn Leu Arg Lys Asn Val Thr Trp Ser Asp Gly Lys Pro Phe Thr Ala 
65                  70                  75                  80  

Asp Asp Val Val Phe Thr Phe Glu Met Leu Arg Lys Phe Pro Ser Leu 
                85                  90                  95      

Asp Thr Gln Gly Ile Trp Ser Ser Gly Leu Glu Ser Val Glu Lys Ile 
            100                 105                 110         

Asp Ser Tyr Thr Val Arg Leu Asn Phe Ser Lys Leu Asn Thr Leu Ile 
        115                 120                 125             

Ile Tyr Asn Ile Ala Gly Val Tyr Met Val Pro Lys His Leu Trp Glu 
    130                 135                 140                 

Lys Leu Asp Asp Pro Ser Lys Phe Thr Asn Glu Asn Pro Val Gly Thr 
145                 150                 155                 160 

Gly Ala Tyr Val Leu Glu Asn Phe Thr Asp Gln Val Phe Thr Leu Lys 
                165                 170                 175     

Lys Arg Val Asp Tyr Trp Gln Ala Glu Lys Val Lys Val Asp Arg Ile 
            180                 185                 190         

Arg Ile Pro Ala Phe Asn Gly Asn Glu Pro Ala Gln Leu Ala Val Ala 
        195                 200                 205             

Asn Gly Glu Leu Asp Trp Ala Gly Ile Asn Tyr Pro Arg Ile Glu Asn 
    210                 215                 220                 

Val Gln Asn Lys Asp Ile Lys Tyr Trp Phe Pro Glu Gly Asn Pro Val 
225                 230                 235                 240 

Phe Leu Phe Phe Asn Leu Glu Arg Asp Pro Phe Lys Asp Pro Ala Phe 
                245                 250                 255     

Arg Lys Ala Ile Ala Arg Ala Val Asn Thr Asp Glu Leu Val Lys Ile 
            260                 265                 270         

Gly Met Thr Asn Tyr Ala Val Lys Ala Asn Pro Val Leu Ile Lys Ser 
        275                 280                 285             

Gly Tyr Ser Tyr Leu Ile Asp Glu Asn Leu Lys Asp Lys Trp Tyr Ser 
    290                 295                 300                 

Phe Asp Ile Gln Gln Ala Lys Ser Glu Leu Ala Ser Leu Gly Phe Arg 
305                 310                 315                 320 

Ala Gly Lys Asp Gly Ile Leu Val Gly Ala Asp Gly Lys Arg Leu Ser 
                325                 330                 335     

Tyr Glu Leu Ile Val Pro Ala Gly Trp Thr Asp Trp Ile Ala Val Ser 
            340                 345                 350         

Gln Leu Leu Ser Gln Gln Leu Lys Lys Ile Gly Val Glu Leu Asn Val 
        355                 360                 365             

Thr Pro Ile Asp Phe Gly Ala Tyr Leu Ala Lys Ile Arg Gln Lys Asp 
    370                 375                 380                 

Phe Asp Val Ala Val Ser Trp Ser Asn Tyr Gly Pro Asn Pro Tyr Ile 
385                 390                 395                 400 

Phe Phe Gln Asn Tyr Leu His Ser Ser Asn Ala Tyr Thr Gly Ser Asn 
                405                 410                 415     

Arg Gly Gly Trp Ile Asn Lys Glu Thr Asp Glu Leu Val Glu Lys Leu 
            420                 425                 430         

Ser Gln Thr Ala Asp Met Glu Glu Ile Lys Thr Ile Val Ser Lys Ile 
        435                 440                 445             

Gln Glu Ile Ile Leu Asp Asn Val Pro Ala Val Pro Leu Phe Tyr Asn 
    450                 455                 460                 

Pro Val Trp Phe Ile Tyr Ser Ile Lys Asn Phe Thr Gly Trp Pro Asn 
465                 470                 475                 480 

Glu Asn Asn Ala Phe Val Glu Pro Arg Thr Thr Gly Met Asp Lys Ile 
                485                 490                 495     

Tyr Leu Ile Met His Leu Gln Pro 
            500                 

<210>   517
<211>   518
<212>   PRT
<213>   Sorangium cellulosum 'So ce 56'

<400>   517
Val Val Thr Ile Ala Arg Glu Gln Gln Ala Thr Trp Val Arg Asn Phe 
                5                   10                  15      

Asn Pro Leu Leu Pro Glu Gly Ser Ala Arg Phe Pro Thr Val Ala Gly 
            20                  25                  30          

Ile Tyr Glu Pro Met Leu Val Tyr Asn Thr Met Arg Ser Asp Tyr Thr 
        35                  40                  45              

Pro Trp Leu Ala Thr Gly Tyr Ala Trp Ser Asp Ala Asn Lys Lys Leu 
    50                  55                  60                  

Thr Phe Thr Thr Arg Ser Gly Val Lys Trp Ser Asp Gly Gln Ala Phe 
65                  70                  75                  80  

Thr Ala Arg Asp Val Ala Phe Thr Phe Ala Leu Leu Lys Lys His Ala 
                85                  90                  95      

Ala Leu Asp Leu Ala Gly Val Trp Arg Phe Leu Gly Ala Val Thr Ala 
            100                 105                 110         

Ile Asp Asp Thr Thr Val Glu Phe Thr Leu Arg Arg Pro Tyr Val Pro 
        115                 120                 125             

Gly Leu Ser Tyr Ile Gly His Gln Pro Ile Val Pro Glu His Val Trp 
    130                 135                 140                 

Lys Asp Val Val Asp Pro Val Thr Phe Ala Asn Glu Asn Pro Val Ala 
145                 150                 155                 160 

Thr Gly Pro Phe Thr Glu Val Lys Val Phe Gln Asn Gln Val Tyr Glu 
                165                 170                 175     

Leu Gly Lys Asn Pro Arg Tyr Trp Gln Glu Gly Lys Pro Ala Val Asp 
            180                 185                 190         

Gly Leu Arg Phe Pro Ala Tyr Pro Ser Asn Asp Gln Val Thr Leu Ala 
        195                 200                 205             

Leu Val Asn Gly Glu Ile Asp Trp Ala Gly Ala Phe Val Pro Asp Ile 
    210                 215                 220                 

Glu Arg Val Phe Val Ala Lys Asp Pro Ala His His His Tyr Trp Phe 
225                 230                 235                 240 

Pro Leu Val Gly Gly Thr Ala Thr Leu Tyr Pro Asn Ala Thr Lys Lys 
                245                 250                 255     

Pro Phe Asp Asp Val Arg Val Arg Lys Ala Ile Ser Met Ala Ile Asp 
            260                 265                 270         

Arg Asp Gln Ile Val Lys Leu Ala Ala Asp Asn Tyr Thr His Gly Ala 
        275                 280                 285             

Asp Ala Thr Gly Leu Asp Asp Ser Tyr Glu Arg Phe Arg Ser Glu Lys 
    290                 295                 300                 

Ala Val Glu Ala Gly Asp Trp Val Lys Phe Asp Pro Gln Arg Ala Asn 
305                 310                 315                 320 

Gln Ile Leu Asp Glu Ala Gly Tyr Pro Arg Gly Ala Asp Gly Ile Arg 
                325                 330                 335     

Thr Arg Leu Gly Lys Pro Met His Phe Glu Ile Asn Val Val Ser Gly 
            340                 345                 350         

Trp Ser Asp Trp Val Arg Ala Val Gln Ile Ile Thr Gln Asn Leu Glu 
        355                 360                 365             

Ser Val Gly Ile Ala Ala Ser Met Lys Thr Tyr Asp Phe Ser Ala Phe 
    370                 375                 380                 

Tyr Ala Ala Leu Gln Lys Gly Leu Phe Asp Met Ser Met Gly Trp Thr 
385                 390                 395                 400 

Ser Val Glu Pro Thr Pro Tyr Asn Phe Tyr Arg Asp Leu Met Ser Ala 
                405                 410                 415     

Asp Leu Val Lys Pro Leu Gly Glu Val Ala Pro Arg Asn Trp His Arg 
            420                 425                 430         

Phe Gly Ala Arg Glu Ala Asp Val Leu Phe His Ala Phe Glu Ser Ala 
        435                 440                 445             

Thr Ala Pro Ala Asp Gln Lys Arg Ile Leu Asp Gly Leu Gln Met Ile 
    450                 455                 460                 

Phe Val Gln Ala Ala Pro Val Ile Pro Leu Phe Asn Asn Pro Ser Trp 
465                 470                 475                 480 

Gly Glu Tyr Ser Thr Lys Arg Phe Thr Gly Phe Pro Thr Met Glu Asn 
                485                 490                 495     

Pro Tyr Ala Lys Leu Thr Pro Asn Asn Pro Pro Glu Tyr Leu Leu Val 
            500                 505                 510         

Leu Thr Glu Leu Arg Pro 
        515             

<210>   518
<211>   576
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   518
Met Gln Lys Gly Glu Arg Asn Met Lys Arg Ser Lys Ser Asn Arg Gly 
                5                   10                  15      

Trp Val Ala Ala Ala Val Gly Leu Ala Val Val Gly Val Ala Gly Cys 
            20                  25                  30          

Gly Ala Ala Asn Thr Ser Ala Asn Gly Ala Ser His Ser Ala Ser Ala 
        35                  40                  45              

Ser Pro Glu Ala Ala Ser Ala Ser Ser Ser Ser Val Leu Thr Val Ala 
    50                  55                  60                  

Pro Asn Val Thr Gly Thr Phe Ser Asp Asn Phe Asn Pro Phe Ser Thr 
65                  70                  75                  80  

Asn Ser Met Pro Gly Thr Leu Gly Asn Ile Tyr Glu Thr Leu Phe Tyr 
                85                  90                  95      

Phe Asp Asn Thr Thr Gly Lys Gln Phe Asn Leu Leu Gly Thr Ser Phe 
            100                 105                 110         

His Phe Ser Asn Gly Gly Lys Ile Leu Thr Val Ser Leu Arg Lys Asn 
        115                 120                 125             

Ala Val Trp Thr Asp Gly Val Pro Phe Thr Ala Gln Asp Val Val Phe 
    130                 135                 140                 

Thr Phe Glu Asp Leu Lys Lys Tyr Pro Asp Ala Asp Thr Asn Gly Val 
145                 150                 155                 160 

Trp Gln Gln Leu Lys Ser Val Gln Ala Asp Gly Lys Tyr Thr Val Val 
                165                 170                 175     

Phe Gln Phe Ala Gln Pro Asn Ile Pro Phe Ala Glu Gln Tyr Val Leu 
            180                 185                 190         

Gly Gly Thr Tyr Ile Val Pro Ala His Gln Trp Lys Ser Leu Gly Asp 
        195                 200                 205             

Pro Ala Lys Ala Lys Ile Thr His Leu Asn Ala Ile Gly Thr Gly Pro 
    210                 215                 220                 

Phe Lys Leu Ser Ser Phe Thr Thr Gln Asp Tyr Gln Phe Thr Ala Asn 
225                 230                 235                 240 

Pro Arg Tyr Tyr Gly Gly Ala Pro Glu Val Lys Thr Leu Asn Tyr Pro 
                245                 250                 255     

Ala Phe Ala Ser Asn Ser Ser Ala Asp Leu Ala Leu Ala Ser Gly Gln 
            260                 265                 270         

Ile Gln Tyr Ala Gly Ile Asn Ile Pro Asn Val Glu Lys Thr Phe Val 
        275                 280                 285             

Ala Ala Asp Pro Ala His Asn His Tyr Leu Phe Pro Pro Asn Glu Ser 
    290                 295                 300                 

Val Glu Leu Tyr Pro Asn Leu His Asn Ser Leu Leu Ala Met Leu Pro 
305                 310                 315                 320 

Val Arg Glu Ala Ile Ser Leu Ala Ile Asp Arg Asp Ala Leu Ser Lys 
                325                 330                 335     

Ile Gly Glu Thr Gly Tyr Glu Lys Pro Ala Val Pro Thr Ser Leu Val 
            340                 345                 350         

Leu Pro Pro Gln Ser Ser Trp Leu Asp Pro Ser Leu Pro Ala Ser Asp 
        355                 360                 365             

Arg Ala Phe Ala Val Asn Asp Ala Lys Ala Val Gln Ile Leu Gln Lys 
    370                 375                 380                 

Ala Gly Phe Arg Lys Asp Gln Asn Gly Ile Phe Ala Leu His Gly Lys 
385                 390                 395                 400 

Glu Leu Ser Phe Asn Leu Leu Thr Ile Ser Gly Trp Ser Asp Trp Asp 
                405                 410                 415     

Glu Asp Ala Leu Leu Ile Lys Gln Gln Leu Ala Lys Val Gly Ile Ala 
            420                 425                 430         

Val Asn Val Gln Glu Glu Gln Phe Ser Ala Tyr Tyr Ser Ala Ile Asp 
        435                 440                 445             

Pro Gly Pro Gly Gln Thr Pro His Tyr Asp Leu Ala Ile Ser Trp Thr 
    450                 455                 460                 

Asn Val Gly Pro Thr Pro Tyr Thr Thr Tyr Tyr Asp Met Leu Asp Ser 
465                 470                 475                 480 

His Gly Ser Phe Asn Leu Glu Gly Tyr Arg Asn Ala Gln Val Asp Gln 
                485                 490                 495     

Trp Phe Asn Glu Phe Ser Ser Thr Thr Asp Ser Gln Val Gln His Gln 
            500                 505                 510         

Val Met Tyr Arg Ile Glu Arg Leu Val Ala Ser Gln Leu Pro Val Ile 
        515                 520                 525             

Pro Leu Leu Asp Gly Ala Leu Trp Tyr Glu Tyr Asn Asp Ser His Phe 
    530                 535                 540                 

Thr Gly Phe Pro Thr Ala Asn Asn Leu Trp Ile Asn Pro Ala Pro Tyr 
545                 550                 555                 560 

Thr Tyr Gln Ala Ala Ala Ile Ile Met Asp His Leu Lys Pro Val Lys 
                565                 570                 575     

<210>   519
<211>   576
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   519
Met Gln Lys Gly Glu Arg Asn Met Lys Arg Ser Lys Ser Asn Arg Gly 
                5                   10                  15      

Trp Val Ala Ala Ala Val Gly Leu Ala Val Val Gly Val Ala Gly Cys 
            20                  25                  30          

Gly Ala Ala Asn Thr Ser Ala Asn Gly Ala Ser His Ser Ala Ser Ala 
        35                  40                  45              

Ser Pro Glu Ala Ala Ser Ala Ser Ser Ser Ser Val Leu Thr Val Ala 
    50                  55                  60                  

Pro Asn Val Thr Gly Thr Phe Ser Asp Asn Phe Asn Pro Phe Ser Thr 
65                  70                  75                  80  

Asn Ser Met Pro Gly Thr Leu Gly Asn Ile Tyr Glu Thr Leu Phe Tyr 
                85                  90                  95      

Phe Asp Asn Thr Thr Gly Lys Gln Phe Asn Leu Leu Gly Thr Ser Phe 
            100                 105                 110         

His Phe Ser Asn Gly Gly Lys Ile Leu Thr Val Ser Leu Arg Lys Asn 
        115                 120                 125             

Ala Val Trp Thr Asp Gly Val Pro Phe Thr Ala Gln Asp Val Val Phe 
    130                 135                 140                 

Thr Phe Glu Asp Leu Lys Lys Tyr Pro Asp Ala Asp Thr Asn Gly Val 
145                 150                 155                 160 

Trp Gln Gln Leu Lys Ser Val Gln Ala Asp Gly Lys Tyr Thr Val Val 
                165                 170                 175     

Phe Gln Phe Ala Gln Pro Asn Ile Pro Phe Ala Glu Gln Tyr Val Leu 
            180                 185                 190         

Gly Gly Thr Tyr Ile Val Pro Ala His Gln Trp Lys Ser Leu Gly Asp 
        195                 200                 205             

Pro Ala Lys Ala Lys Ile Thr His Leu Asn Ala Ile Gly Thr Gly Pro 
    210                 215                 220                 

Phe Lys Leu Ser Ser Phe Thr Thr Gln Asp Tyr Gln Phe Thr Ala Asn 
225                 230                 235                 240 

Pro Arg Tyr Tyr Gly Gly Ala Pro Glu Val Lys Thr Leu Asn Tyr Pro 
                245                 250                 255     

Ala Phe Ala Ser Asn Ser Ser Ala Asp Leu Ala Leu Ala Ser Gly Gln 
            260                 265                 270         

Ile Gln Tyr Ala Gly Ile Gln Ile Pro Asn Val Glu Lys Thr Phe Val 
        275                 280                 285             

Ala Ala Asp Pro Ala His Asn His Tyr Leu Phe Pro Pro Asn Glu Ser 
    290                 295                 300                 

Val Glu Leu Tyr Pro Asn Leu His Asn Ser Leu Leu Ala Met Leu Pro 
305                 310                 315                 320 

Val Arg Glu Ala Ile Ser Leu Ala Ile Asp Arg Asp Ala Leu Ser Lys 
                325                 330                 335     

Ile Gly Glu Thr Gly Tyr Glu Lys Pro Ala Val Pro Thr Ser Leu Val 
            340                 345                 350         

Leu Pro Pro Gln Ser Ser Trp Leu Asp Pro Ser Leu Pro Ala Ser Asp 
        355                 360                 365             

Arg Ala Phe Ala Val Asn Asp Ala Lys Ala Val Gln Ile Leu Gln Lys 
    370                 375                 380                 

Ala Gly Phe Arg Lys Asp Gln Asn Gly Ile Phe Ala Leu His Gly Lys 
385                 390                 395                 400 

Glu Leu Ser Phe Asn Leu Leu Thr Val Ser Gly Trp Ser Asp Trp Asp 
                405                 410                 415     

Glu Asp Ala Leu Leu Ile Lys Gln Gln Leu Ala Lys Val Gly Ile Ala 
            420                 425                 430         

Val Asn Val Gln Glu Glu Gln Phe Ser Ala Tyr Tyr Ser Ala Ile Asp 
        435                 440                 445             

Pro Gly Pro Gly Gln Thr Pro His Tyr Asp Leu Ala Ile Ser Trp Thr 
    450                 455                 460                 

Asn Val Gly Pro Thr Pro Tyr Thr Thr Tyr Tyr Asp Met Leu Asp Ser 
465                 470                 475                 480 

His Gly Ser Phe Asn Leu Glu Gly Tyr Arg Asn Ala Gln Val Asp Gln 
                485                 490                 495     

Trp Phe Asn Glu Phe Ser Ser Thr Thr Asp Ser Gln Val Gln His Gln 
            500                 505                 510         

Val Met Tyr Arg Ile Glu Arg Leu Val Ala Ser Gln Leu Pro Val Ile 
        515                 520                 525             

Pro Leu Leu Asp Gly Ala Leu Trp Tyr Glu Tyr Asn Asp Ser His Phe 
    530                 535                 540                 

Thr Gly Phe Pro Thr Ala Asn Asn Leu Trp Ile Asn Pro Ala Pro Tyr 
545                 550                 555                 560 

Thr Tyr Gln Ala Ala Ala Ile Ile Met Asp His Leu Lys Pro Val Lys 
                565                 570                 575     

<210>   520
<211>   576
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   520
Met Gln Lys Gly Glu Arg Asn Met Lys Arg Ser Lys Ser Asn Arg Gly 
                5                   10                  15      

Trp Val Ala Ala Ala Val Gly Leu Ala Val Val Gly Val Ala Gly Cys 
            20                  25                  30          

Gly Ala Ala Asn Thr Ser Ala Asn Gly Ala Ser His Ser Ala Ser Ala 
        35                  40                  45              

Ser Pro Glu Ala Ala Ser Ala Ser Ser Ser Ser Val Leu Thr Val Ala 
    50                  55                  60                  

Pro Asn Val Thr Gly Thr Phe Ser Asp Asn Phe Asn Pro Phe Ser Thr 
65                  70                  75                  80  

Asn Ser Met Pro Gly Thr Leu Gly Asn Ile Tyr Glu Thr Leu Phe Tyr 
                85                  90                  95      

Phe Asp Asn Thr Thr Gly Lys Gln Phe Asn Leu Leu Gly Thr Ser Phe 
            100                 105                 110         

His Phe Ser Asn Gly Gly Lys Ile Leu Thr Val Ser Leu Arg Lys Asn 
        115                 120                 125             

Ala Val Trp Thr Asp Gly Val Pro Phe Thr Ala Gln Asp Val Val Phe 
    130                 135                 140                 

Thr Phe Glu Asp Leu Lys Lys Tyr Pro Asp Ala Asp Thr Asn Gly Val 
145                 150                 155                 160 

Trp Gln Gln Leu Lys Ser Val Gln Ala Asp Gly Lys Tyr Thr Val Val 
                165                 170                 175     

Phe Gln Phe Ala Gln Pro Asn Ile Pro Phe Ala Glu Gln Tyr Val Leu 
            180                 185                 190         

Gly Gly Thr Tyr Ile Val Pro Ala His Gln Trp Lys Ser Leu Gly Asp 
        195                 200                 205             

Pro Ala Lys Ala Lys Ile Thr His Leu Asn Ala Ile Gly Thr Gly Pro 
    210                 215                 220                 

Phe Lys Leu Ser Ser Phe Thr Thr Gln Asp Tyr Gln Phe Thr Ala Asn 
225                 230                 235                 240 

Pro Arg Tyr Tyr Gly Gly Ala Pro Glu Val Lys Thr Leu Asn Tyr Pro 
                245                 250                 255     

Ala Phe Ala Ser Asn Ser Ser Ala Asp Leu Ala Leu Ala Ser Gly Gln 
            260                 265                 270         

Ile Gln Tyr Ala Gly Ile Asn Ile Pro Asn Val Glu Lys Thr Phe Val 
        275                 280                 285             

Ala Ala Asp Pro Ala His Asn His Tyr Leu Phe Pro Pro Asn Glu Ser 
    290                 295                 300                 

Val Glu Leu Tyr Pro Asn Leu His Asn Ser Leu Leu Ala Met Ile Pro 
305                 310                 315                 320 

Val Arg Glu Ala Ile Ser Leu Ala Ile Asp Arg Asp Ala Leu Ser Lys 
                325                 330                 335     

Ile Gly Glu Thr Gly Tyr Glu Lys Pro Ala Val Pro Thr Ser Leu Val 
            340                 345                 350         

Leu Pro Pro Gln Ser Ser Trp Leu Asp Pro Ser Leu Pro Ala Ser Asp 
        355                 360                 365             

Arg Ala Phe Ala Val Asn Asp Ala Lys Ala Val Gln Ile Leu Gln Lys 
    370                 375                 380                 

Ala Gly Phe Arg Lys Asp Gln Asn Gly Ile Phe Ala Leu His Gly Lys 
385                 390                 395                 400 

Glu Leu Ser Phe Asn Leu Leu Thr Val Ser Gly Trp Ser Asp Trp Asp 
                405                 410                 415     

Glu Asp Ala Leu Leu Ile Lys Gln Gln Leu Ala Lys Val Gly Ile Ala 
            420                 425                 430         

Val Asn Val Gln Glu Glu Gln Phe Ser Ala Tyr Tyr Ser Ala Ile Asp 
        435                 440                 445             

Pro Gly Pro Gly Gln Thr Pro His Tyr Asp Leu Ala Ile Ser Trp Thr 
    450                 455                 460                 

Asn Val Gly Pro Thr Pro Tyr Thr Thr Tyr Tyr Asp Met Leu Asp Ser 
465                 470                 475                 480 

His Gly Ser Phe Asn Leu Glu Gly Tyr Arg Asn Ala Gln Val Asp Gln 
                485                 490                 495     

Trp Phe Asn Glu Phe Ser Ser Thr Thr Asp Ser Gln Val Gln His Gln 
            500                 505                 510         

Val Met Tyr Arg Ile Glu Arg Leu Val Ala Ser Gln Leu Pro Val Ile 
        515                 520                 525             

Pro Leu Leu Asp Gly Ala Leu Trp Tyr Glu Tyr Asn Asp Ser His Phe 
    530                 535                 540                 

Thr Gly Phe Pro Thr Ala Asn Asn Leu Trp Ile Asn Pro Ala Pro Tyr 
545                 550                 555                 560 

Thr Tyr Gln Ala Ala Ala Ile Ile Met Asp His Leu Lys Pro Val Lys 
                565                 570                 575     

<210>   521
<211>   576
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   521
Met Gln Lys Gly Glu Arg Asn Met Lys Arg Ser Lys Ser Asn Arg Gly 
                5                   10                  15      

Trp Val Ala Ala Ala Val Gly Leu Ala Val Val Gly Val Ala Gly Cys 
            20                  25                  30          

Gly Ala Ala Asn Thr Ser Ala Asn Gly Ala Ser His Ser Ala Ser Ala 
        35                  40                  45              

Ser Pro Glu Ala Ala Ser Ala Ser Ser Ser Ser Val Leu Thr Val Ala 
    50                  55                  60                  

Pro Asn Val Thr Gly Thr Phe Ser Asp Asn Phe Asn Pro Phe Ser Thr 
65                  70                  75                  80  

Asn Ser Met Pro Gly Thr Leu Gly Asn Ile Tyr Glu Thr Leu Phe Tyr 
                85                  90                  95      

Phe Asp Asn Thr Thr Gly Lys Gln Phe Asn Leu Leu Gly Thr Ser Phe 
            100                 105                 110         

His Phe Ser Asn Gly Gly Lys Ile Leu Thr Val Ser Leu Arg Lys Asn 
        115                 120                 125             

Ala Val Trp Thr Asp Gly Val Pro Phe Thr Ala Gln Asp Val Val Phe 
    130                 135                 140                 

Thr Phe Glu Asp Leu Lys Lys Tyr Pro Asp Ala Asp Thr Asn Gly Val 
145                 150                 155                 160 

Trp Gln Gln Leu Lys Ser Val Gln Ala Asp Gly Lys Tyr Thr Val Val 
                165                 170                 175     

Phe Gln Phe Ala Gln Pro Asn Ile Pro Phe Ala Glu Gln Tyr Val Leu 
            180                 185                 190         

Gly Gly Thr Tyr Ile Val Pro Ala His Gln Trp Lys Ser Leu Gly Asp 
        195                 200                 205             

Pro Ala Lys Ala Lys Ile Thr His Leu Asn Ala Ile Gly Thr Gly Pro 
    210                 215                 220                 

Phe Lys Leu Ser Ser Phe Thr Thr Gln Asp Tyr Gln Phe Thr Ala Asn 
225                 230                 235                 240 

Pro Arg Tyr Tyr Gly Gly Ala Pro Glu Val Lys Thr Leu Asn Tyr Pro 
                245                 250                 255     

Ala Phe Ala Ser Asn Ser Ser Ala Asp Leu Ala Leu Ala Ser Gly Gln 
            260                 265                 270         

Ile Gln Tyr Ala Gly Ile Asn Ile Pro Asn Val Glu Lys Thr Phe Val 
        275                 280                 285             

Ala Ala Asp Pro Ala His Asn His Tyr Leu Phe Pro Pro Asn Glu Ser 
    290                 295                 300                 

Val Glu Leu Tyr Pro Asn Leu His Asn Ser Leu Leu Ala Met Leu Pro 
305                 310                 315                 320 

Val Arg Glu Ala Ile Ser Leu Ala Ile Asp Arg Asp Ala Leu Ser Lys 
                325                 330                 335     

Ile Gly Glu Thr Gly Tyr Glu Lys Pro Ala Val Pro Thr Ser Leu Val 
            340                 345                 350         

Leu Pro Pro Gln Ser Ser Trp Leu Asp Pro Ser Leu Pro Ala Ser Asp 
        355                 360                 365             

Arg Ala Phe Ala Val Asn Asp Ala Lys Ala Val Gln Ile Leu Gln Lys 
    370                 375                 380                 

Ala Gly Phe Arg Lys Asp Gln Asn Gly Ile Phe Ala Leu His Gly Lys 
385                 390                 395                 400 

Glu Leu Ser Phe Asn Leu Leu Thr Val Ser Gly Trp Ser Asp Trp Asp 
                405                 410                 415     

Glu Asp Ala Leu Leu Ile Lys Gln Gln Leu Ala Lys Val Gly Ile Ala 
            420                 425                 430         

Val Asn Val Gln Glu Glu Gln Phe Ser Ala Tyr Tyr Ser Ala Ile Asp 
        435                 440                 445             

Pro Gly Pro Gly Gln Thr Pro His Tyr Asp Leu Ala Ile Ser Trp Thr 
    450                 455                 460                 

Asn Val Gly Pro Thr Pro Tyr Thr Thr Tyr Tyr Asp Met Leu Asp Ser 
465                 470                 475                 480 

His Gly Ser Phe Asn Leu Glu Gly Tyr Arg Asn Ala Gln Val Asp Gln 
                485                 490                 495     

Trp Phe Asn Glu Phe Ser Ser Thr Thr Asp Ser Gln Val Gln His Gln 
            500                 505                 510         

Val Met Tyr Arg Leu Glu Arg Leu Val Ala Ser Gln Leu Pro Val Ile 
        515                 520                 525             

Pro Leu Leu Asp Gly Ala Leu Trp Tyr Glu Tyr Asn Asp Ser His Phe 
    530                 535                 540                 

Thr Gly Phe Pro Thr Ala Asn Asn Leu Trp Ile Asn Pro Ala Pro Tyr 
545                 550                 555                 560 

Thr Tyr Gln Ala Ala Ala Ile Ile Met Asp His Leu Lys Pro Val Lys 
                565                 570                 575     

<210>   522
<211>   576
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 511

<400>   522
Met Gln Lys Gly Glu Arg Asn Met Lys Arg Ser Lys Ser Asn Arg Gly 
                5                   10                  15      

Trp Val Ala Ala Ala Val Gly Leu Ala Val Val Gly Val Ala Gly Cys 
            20                  25                  30          

Gly Ala Ala Asn Thr Ser Ala Asn Gly Ala Ser His Ser Ala Ser Ala 
        35                  40                  45              

Ser Pro Glu Ala Ala Ser Ala Ser Ser Ser Ser Val Leu Thr Val Ala 
    50                  55                  60                  

Pro Asn Val Thr Gly Thr Phe Ser Asp Asn Phe Asn Pro Phe Ser Thr 
65                  70                  75                  80  

Asn Ser Met Pro Gly Thr Leu Gly Asn Ile Tyr Glu Thr Leu Phe Tyr 
                85                  90                  95      

Phe Asp Asn Thr Thr Gly Lys Gln Phe Asn Leu Leu Gly Thr Ser Phe 
            100                 105                 110         

His Phe Ser Asn Gly Gly Lys Ile Leu Thr Val Ser Leu Arg Lys Asn 
        115                 120                 125             

Ala Val Trp Thr Asp Gly Val Pro Phe Thr Ala Gln Asp Val Val Phe 
    130                 135                 140                 

Thr Phe Glu Asp Leu Lys Lys Tyr Pro Asp Ala Asp Thr Asn Gly Val 
145                 150                 155                 160 

Trp Gln Gln Leu Lys Ser Val Gln Ala Asp Gly Lys Tyr Thr Val Val 
                165                 170                 175     

Phe Gln Phe Ala Gln Pro Asn Ile Pro Phe Ala Glu Gln Tyr Val Leu 
            180                 185                 190         

Gly Gly Thr Tyr Ile Val Pro Ala His Gln Trp Lys Ser Leu Gly Asp 
        195                 200                 205             

Pro Ala Arg Ala Lys Ile Thr His Leu Asn Ala Ile Gly Thr Gly Pro 
    210                 215                 220                 

Phe Lys Leu Ser Ser Phe Thr Thr Gln Asp Tyr Gln Phe Thr Ala Asn 
225                 230                 235                 240 

Pro Arg Tyr Tyr Gly Gly Ala Pro Glu Val Lys Thr Leu Asn Tyr Pro 
                245                 250                 255     

Ala Phe Ala Ser Asn Ser Ser Ala Asp Leu Ala Leu Ala Ser Gly Gln 
            260                 265                 270         

Ile Gln Tyr Ala Gly Ile Asn Ile Pro Asn Val Glu Lys Thr Phe Val 
        275                 280                 285             

Ala Ala Asp Pro Ala His Asn His Tyr Leu Phe Pro Pro Asn Glu Ser 
    290                 295                 300                 

Val Glu Leu Tyr Pro Asn Leu His Asn Ser Leu Leu Ala Met Leu Pro 
305                 310                 315                 320 

Val Arg Glu Ala Ile Ser Leu Ala Ile Asp Arg Asp Ala Leu Ser Lys 
                325                 330                 335     

Ile Gly Glu Thr Gly Tyr Glu Lys Pro Ala Val Pro Thr Ser Leu Val 
            340                 345                 350         

Leu Pro Pro Gln Ser Ser Trp Leu Asp Pro Ser Leu Pro Ala Ser Asp 
        355                 360                 365             

Arg Ala Phe Ala Val Asn Asp Ala Lys Ala Val Gln Ile Leu Gln Lys 
    370                 375                 380                 

Ala Gly Phe Arg Lys Asp Gln Asn Gly Ile Phe Ala Leu His Gly Lys 
385                 390                 395                 400 

Glu Leu Ser Phe Asn Leu Leu Thr Val Ser Gly Trp Ser Asp Trp Asp 
                405                 410                 415     

Glu Asp Ala Leu Leu Ile Lys Gln Gln Leu Ala Lys Val Gly Ile Ala 
            420                 425                 430         

Val Asn Val Gln Glu Glu Gln Phe Ser Ala Tyr Tyr Ser Ala Ile Asp 
        435                 440                 445             

Pro Gly Pro Gly Gln Thr Pro His Tyr Asp Leu Ala Ile Ser Trp Thr 
    450                 455                 460                 

Asn Val Gly Pro Thr Pro Tyr Thr Thr Tyr Tyr Asp Met Leu Asp Ser 
465                 470                 475                 480 

His Gly Ser Phe Asn Leu Glu Gly Tyr Arg Asn Ala Gln Val Asp Gln 
                485                 490                 495     

Trp Phe Asn Glu Phe Ser Ser Thr Thr Asp Ser Gln Val Gln His Gln 
            500                 505                 510         

Val Met Tyr Arg Ile Glu Arg Leu Val Ala Ser Gln Leu Pro Val Ile 
        515                 520                 525             

Pro Leu Leu Asp Gly Ala Leu Trp Tyr Glu Tyr Asn Asp Ser His Phe 
    530                 535                 540                 

Thr Gly Phe Pro Thr Ala Asn Asn Leu Trp Ile Asn Pro Ala Pro Tyr 
545                 550                 555                 560 

Thr Tyr Gln Ala Ala Ala Ile Ile Met Asp His Leu Lys Pro Val Lys 
                565                 570                 575     

<210>   523
<211>   1731
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   523
gtgcaaaagg gggaacgaaa catgaagcgg tcgaagagca atcgaggatg ggtcgccgct       60

gcggtcggtc tcgccgtggt gggtgtcgcc gggtgcggcg cagcgaacac ctcggcgaac      120

ggcgccagcc attctgcctc ggcgtcgcca gaggcggcga gcgcgtcgtc gagttcggtc      180

ctgaccgtcg cgccgaacgt cacgggcacc ttttcggaca acttcaatcc gtttagcacc      240

aacagcatgc ccggcaccct aggcaacatc tacgagacat tgttctactt cgacaatacg      300

acagggaaac agttcaacct gttggggacc tccttccact tttcgaacgg agggaaaatc      360

ctgacggttt ctctgcgaaa aaacgcggtc tggacggacg gagtcccgtt cacggcgcag      420

gatgttgtct tcacgttcga ggatctcaag aagtatcccg acgcggatac caacggcgtg      480

tggcagcagc tgaagagcgt ccaggccgac ggaaagtaca ccgtggtctt ccagttcgcg      540

cagcccaaca tcccgtttgc cgagcagtac gtccttgggg gcacgtacat tgtgccggct      600

catcagtgga agtcgcttgg cgatccggcc aaggccaaga tcacgcactt gaacgccatt      660

ggcacgggtc cattcaagct gtcgtccttt acaactcagg actaccaatt caccgcaaat      720

ccgcgttact acggaggggc acctgaggtc aagaccctca attatccggc gttcgccagc      780

aactcgagtg ccgatttggc gctcgcgagc ggtcagattc aatacgccgg catcaacatt      840

cccaatgtcg agaagacctt cgtggcagcc gatccggcgc acaaccacta tttgttcccg      900

cccaacgaat cggtggagct ctatccgaac ctgcacaact cgctgctcgc catgctgcct      960

gtgcgcgagg ccatcagcct ggccatcgat cgcgacgcac tctccaaaat cggagagacg     1020

ggctatgaga agccagccgt gccgacgagt ctcgtcttac cgccacagtc gtcgtggttg     1080

gacccgagtc tgcccgcgag cgatcgcgcc tttgcggtca acgatgccaa agcggttcag     1140

attttgcaga aggcaggctt ccgcaaggac caaaacggga tttttgcgct ccatggcaag     1200

gagttgtcct tcaacttact cacgattagc ggttggagcg actgggatga ggacgcgctg     1260

ctcatcaagc agcagttggc gaaggtcggg atcgccgtga atgtccagga ggagcagttc     1320

tcggcctact acagcgctat cgatccgggc ccgggccaga cgccgcacta cgacctcgcc     1380

atctcgtgga ccaacgtggg gcctacgccg tacacgacgt attacgacat gttggattcg     1440

cacggatcct ttaatttgga aggctatcgc aatgcgcagg tggatcagtg gttcaacgag     1500

ttttcgtcga ccacggatag ccaggttcag caccaggtga tgtacaggat tgagcgactc     1560

gtggcgagcc aactgccggt catcccgctg ttggatggcg cgctctggta cgagtacaac     1620

gacagccact tcacgggctt cccgacggcc aacaacctct ggatcaatcc ggcgccgtac     1680

acctaccagg cggctgccat catcatggat cacctgaagc cggtgaagtg a              1731


<210>   524
<211>   1731
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   524
gtgcaaaagg gggaacgaaa catgaagcgg tcgaagagca atcgaggatg ggtcgccgct       60

gcggtcggtc tcgccgtggt gggtgtcgcc gggtgcggcg cagcgaacac ctcggcgaac      120

ggcgccagcc attctgcctc ggcgtcgcca gaggcggcga gcgcgtcgtc gagttcggtc      180

ctgaccgtcg cgccgaacgt cacgggcacc ttttcggaca acttcaatcc gtttagcacc      240

aacagcatgc ccggcaccct aggcaacatc tacgagacat tgttctactt cgacaatacg      300

acagggaaac agttcaacct gttggggacc tccttccact tttcgaacgg agggaaaatc      360

ctgacggttt ctctgcgaaa aaacgcggtc tggacggacg gagtcccgtt cacggcgcag      420

gatgttgtct tcacgttcga ggatctcaag aagtatcccg acgcggatac caacggcgtg      480

tggcagcagc tgaagagcgt ccaggccgac ggaaagtaca ccgtggtctt ccagttcgcg      540

cagcccaaca tcccgtttgc cgagcagtac gtccttgggg gcacgtacat tgtgccggct      600

catcagtgga agtcgcttgg cgatccggcc aaggccaaga tcacgcactt gaacgccatt      660

ggcacgggtc cattcaagct gtcgtccttt acaactcagg actaccaatt caccgcaaat      720

ccgcgttact acggaggggc acctgaggtc aagaccctca attatccggc gttcgccagc      780

aactcgagtg ccgatttggc gctcgcgagc ggtcagattc aatacgccgg catccaaatt      840

cccaatgtcg agaagacctt cgtggcagcc gatccggcgc acaaccacta tttgttcccg      900

cccaacgaat cggtggagct ctatccgaac ctgcacaact cgctgctcgc catgctgcct      960

gtgcgcgagg ccatcagcct ggccatcgat cgcgacgcac tctccaaaat cggagagacg     1020

ggctatgaga agccagccgt gccgacgagt ctcgtcttac cgccacagtc gtcgtggttg     1080

gacccgagtc tgcccgcgag cgatcgcgcc tttgcggtca acgatgccaa agcggttcag     1140

attttgcaga aggcaggctt ccgcaaggac caaaacggga tttttgcgct ccatggcaag     1200

gagttgtcct tcaacttact cacggtaagc ggttggagcg actgggatga ggacgcgctg     1260

ctcatcaagc agcagttggc gaaggtcggg atcgccgtga atgtccagga ggagcagttc     1320

tcggcctact acagcgctat cgatccgggc ccgggccaga cgccgcacta cgacctcgcc     1380

atctcgtgga ccaacgtggg gcctacgccg tacacgacgt attacgacat gttggattcg     1440

cacggatcct ttaatttgga aggctatcgc aatgcgcagg tggatcagtg gttcaacgag     1500

ttttcgtcga ccacggatag ccaggttcag caccaggtga tgtacaggat tgagcgactc     1560

gtggcgagcc aactgccggt catcccgctg ttggatggcg cgctctggta cgagtacaac     1620

gacagccact tcacgggctt cccgacggcc aacaacctct ggatcaatcc ggcgccgtac     1680

acctaccagg cggctgccat catcatggat cacctgaagc cggtgaagtg a              1731


<210>   525
<211>   1731
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   525
gtgcaaaagg gggaacgaaa catgaagcgg tcgaagagca atcgaggatg ggtcgccgct       60

gcggtcggtc tcgccgtggt gggtgtcgcc gggtgcggcg cagcgaacac ctcggcgaac      120

ggcgccagcc attctgcctc ggcgtcgcca gaggcggcga gcgcgtcgtc gagttcggtc      180

ctgaccgtcg cgccgaacgt cacgggcacc ttttcggaca acttcaatcc gtttagcacc      240

aacagcatgc ccggcaccct aggcaacatc tacgagacat tgttctactt cgacaatacg      300

acagggaaac agttcaacct gttggggacc tccttccact tttcgaacgg agggaaaatc      360

ctgacggttt ctctgcgaaa aaacgcggtc tggacggacg gagtcccgtt cacggcgcag      420

gatgttgtct tcacgttcga ggatctcaag aagtatcccg acgcggatac caacggcgtg      480

tggcagcagc tgaagagcgt ccaggccgac ggaaagtaca ccgtggtctt ccagttcgcg      540

cagcccaaca tcccgtttgc cgagcagtac gtccttgggg gcacgtacat tgtgccggct      600

catcagtgga agtcgcttgg cgatccggcc aaggccaaga tcacgcactt gaacgccatt      660

ggcacgggtc cattcaagct gtcgtccttt acaactcagg actaccaatt caccgcaaat      720

ccgcgttact acggaggggc acctgaggtc aagaccctca attatccggc gttcgccagc      780

aactcgagtg ccgatttggc gctcgcgagc ggtcagattc aatacgccgg catcaacatt      840

cccaatgtcg agaagacctt cgtggcagcc gatccggcgc acaaccacta tttgttcccg      900

cccaacgaat cggtggagct ctatccgaac ctgcacaact cgctgctcgc catgattcct      960

gtgcgcgagg ccatcagcct ggccatcgat cgcgacgcac tctccaaaat cggagagacg     1020

ggctatgaga agccagccgt gccgacgagt ctcgtcttac cgccacagtc gtcgtggttg     1080

gacccgagtc tgcccgcgag cgatcgcgcc tttgcggtca acgatgccaa agcggttcag     1140

attttgcaga aggcaggctt ccgcaaggac caaaacggga tttttgcgct ccatggcaag     1200

gagttgtcct tcaacttact cacggtaagc ggttggagcg actgggatga ggacgcgctg     1260

ctcatcaagc agcagttggc gaaggtcggg atcgccgtga atgtccagga ggagcagttc     1320

tcggcctact acagcgctat cgatccgggc ccgggccaga cgccgcacta cgacctcgcc     1380

atctcgtgga ccaacgtggg gcctacgccg tacacgacgt attacgacat gttggattcg     1440

cacggatcct ttaatttgga aggctatcgc aatgcgcagg tggatcagtg gttcaacgag     1500

ttttcgtcga ccacggatag ccaggttcag caccaggtga tgtacaggat tgagcgactc     1560

gtggcgagcc aactgccggt catcccgctg ttggatggcg cgctctggta cgagtacaac     1620

gacagccact tcacgggctt cccgacggcc aacaacctct ggatcaatcc ggcgccgtac     1680

acctaccagg cggctgccat catcatggat cacctgaagc cggtgaagtg a              1731


<210>   526
<211>   1731
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   526
gtgcaaaagg gggaacgaaa catgaagcgg tcgaagagca atcgaggatg ggtcgccgct       60

gcggtcggtc tcgccgtggt gggtgtcgcc gggtgcggcg cagcgaacac ctcggcgaac      120

ggcgccagcc attctgcctc ggcgtcgcca gaggcggcga gcgcgtcgtc gagttcggtc      180

ctgaccgtcg cgccgaacgt cacgggcacc ttttcggaca acttcaatcc gtttagcacc      240

aacagcatgc ccggcaccct aggcaacatc tacgagacat tgttctactt cgacaatacg      300

acagggaaac agttcaacct gttggggacc tccttccact tttcgaacgg agggaaaatc      360

ctgacggttt ctctgcgaaa aaacgcggtc tggacggacg gagtcccgtt cacggcgcag      420

gatgttgtct tcacgttcga ggatctcaag aagtatcccg acgcggatac caacggcgtg      480

tggcagcagc tgaagagcgt ccaggccgac ggaaagtaca ccgtggtctt ccagttcgcg      540

cagcccaaca tcccgtttgc cgagcagtac gtccttgggg gcacgtacat tgtgccggct      600

catcagtgga agtcgcttgg cgatccggcc aaggccaaga tcacgcactt gaacgccatt      660

ggcacgggtc cattcaagct gtcgtccttt acaactcagg actaccaatt caccgcaaat      720

ccgcgttact acggaggggc acctgaggtc aagaccctca attatccggc gttcgccagc      780

aactcgagtg ccgatttggc gctcgcgagc ggtcagattc aatacgccgg catcaacatt      840

cccaatgtcg agaagacctt cgtggcagcc gatccggcgc acaaccacta tttgttcccg      900

cccaacgaat cggtggagct ctatccgaac ctgcacaact cgctgctcgc catgctgcct      960

gtgcgcgagg ccatcagcct ggccatcgat cgcgacgcac tctccaaaat cggagagacg     1020

ggctatgaga agccagccgt gccgacgagt ctcgtcttac cgccacagtc gtcgtggttg     1080

gacccgagtc tgcccgcgag cgatcgcgcc tttgcggtca acgatgccaa agcggttcag     1140

attttgcaga aggcaggctt ccgcaaggac caaaacggga tttttgcgct ccatggcaag     1200

gagttgtcct tcaacttact cacggtaagc ggttggagcg actgggatga ggacgcgctg     1260

ctcatcaagc agcagttggc gaaggtcggg atcgccgtga atgtccagga ggagcagttc     1320

tcggcctact acagcgctat cgatccgggc ccgggccaga cgccgcacta cgacctcgcc     1380

atctcgtgga ccaacgtggg gcctacgccg tacacgacgt attacgacat gttggattcg     1440

cacggatcct ttaatttgga aggctatcgc aatgcgcagg tggatcagtg gttcaacgag     1500

ttttcgtcga ccacggatag ccaggttcag caccaggtga tgtacaggtt agagcgactc     1560

gtggcgagcc aactgccggt catcccgctg ttggatggcg cgctctggta cgagtacaac     1620

gacagccact tcacgggctt cccgacggcc aacaacctct ggatcaatcc ggcgccgtac     1680

acctaccagg cggctgccat catcatggat cacctgaagc cggtgaagtg a              1731


<210>   527
<211>   1731
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 512

<400>   527
gtgcaaaagg gggaacgaaa catgaagcgg tcgaagagca atcgaggatg ggtcgccgct       60

gcggtcggtc tcgccgtggt gggtgtcgcc gggtgcggcg cagcgaacac ctcggcgaac      120

ggcgccagcc attctgcctc ggcgtcgcca gaggcggcga gcgcgtcgtc gagttcggtc      180

ctgaccgtcg cgccgaacgt cacgggcacc ttttcggaca acttcaatcc gtttagcacc      240

aacagcatgc ccggcaccct aggcaacatc tacgagacat tgttctactt cgacaatacg      300

acagggaaac agttcaacct gttggggacc tccttccact tttcgaacgg agggaaaatc      360

ctgacggttt ctctgcgaaa aaacgcggtc tggacggacg gagtcccgtt cacggcgcag      420

gatgttgtct tcacgttcga ggatctcaag aagtatcccg acgcggatac caacggcgtg      480

tggcagcagc tgaagagcgt ccaggccgac ggaaagtaca ccgtggtctt ccagttcgcg      540

cagcccaaca tcccgtttgc cgagcagtac gtccttgggg gcacgtacat tgtgccggct      600

catcagtgga agtcgcttgg cgatccggcc cgtgccaaga tcacgcactt gaacgccatt      660

ggcacgggtc cattcaagct gtcgtccttt acaactcagg actaccaatt caccgcaaat      720

ccgcgttact acggaggggc acctgaggtc aagaccctca attatccggc gttcgccagc      780

aactcgagtg ccgatttggc gctcgcgagc ggtcagattc aatacgccgg catcaacatt      840

cccaatgtcg agaagacctt cgtggcagcc gatccggcgc acaaccacta tttgttcccg      900

cccaacgaat cggtggagct ctatccgaac ctgcacaact cgctgctcgc catgctgcct      960

gtgcgcgagg ccatcagcct ggccatcgat cgcgacgcac tctccaaaat cggagagacg     1020

ggctatgaga agccagccgt gccgacgagt ctcgtcttac cgccacagtc gtcgtggttg     1080

gacccgagtc tgcccgcgag cgatcgcgcc tttgcggtca acgatgccaa agcggttcag     1140

attttgcaga aggcaggctt ccgcaaggac caaaacggga tttttgcgct ccatggcaag     1200

gagttgtcct tcaacttact cacggtaagc ggttggagcg actgggatga ggacgcgctg     1260

ctcatcaagc agcagttggc gaaggtcggg atcgccgtga atgtccagga ggagcagttc     1320

tcggcctact acagcgctat cgatccgggc ccgggccaga cgccgcacta cgacctcgcc     1380

atctcgtgga ccaacgtggg gcctacgccg tacacgacgt attacgacat gttggattcg     1440

cacggatcct ttaatttgga aggctatcgc aatgcgcagg tggatcagtg gttcaacgag     1500

ttttcgtcga ccacggatag ccaggttcag caccaggtga tgtacaggat tgagcgactc     1560

gtggcgagcc aactgccggt catcccgctg ttggatggcg cgctctggta cgagtacaac     1620

gacagccact tcacgggctt cccgacggcc aacaacctct ggatcaatcc ggcgccgtac     1680

acctaccagg cggctgccat catcatggat cacctgaagc cggtgaagtg a              1731


<210>   528
<211>   328
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   528
Met Arg Tyr Phe Leu Asn Arg Phe Cys Phe Leu Val Leu Ser Leu Trp 
                5                   10                  15      

Ala Ala Ile Thr Leu Asn Phe Ile Leu Pro Arg Leu Met Pro Gly Asn 
            20                  25                  30          

Pro Ala Gln Ala Met Ile Ala Lys Gln Ala Gly Asn Ile Asn Pro Ala 
        35                  40                  45              

Ala Leu Lys Ala Ile Glu Glu Gln Leu Gly Leu Ser Asn Gly Pro Leu 
    50                  55                  60                  

Trp Gln Gln Tyr Phe Gln Tyr Leu Gly Asn Leu Leu Thr Gly His Trp 
65                  70                  75                  80  

Gly Ala Ser Phe Gln Tyr Phe Pro Thr Pro Val Val Asn Ile Ile Glu 
                85                  90                  95      

Thr Ser Leu Pro Trp Thr Ile Val Leu Leu Gly Val Val Thr Ile Ile 
            100                 105                 110         

Ser Val Val Val Gly Thr Leu Ile Gly Ile Leu Ile Ala Trp Arg Arg 
        115                 120                 125             

Gly Gly Thr Ala Asp Asn Val Ile Pro Val Ala Thr Met Phe Gly Gln 
    130                 135                 140                 

Ala Ile Pro Thr Phe Trp Leu Gly Leu Ile Leu Ile Tyr Phe Phe Gly 
145                 150                 155                 160 

Phe Val His His Trp Phe Pro Leu Ala His Gly Tyr Gly Asp Asp Val 
                165                 170                 175     

Thr Pro Gly Leu Asn Ala Pro Phe Leu Ala Ser Ala Val Tyr His Ser 
            180                 185                 190         

Ile Leu Pro Ala Val Val Val Phe Val Gly Ser Ile Ser Gly Trp Ile 
        195                 200                 205             

Val Gly Met Arg Asn Asn Met Ile Thr Thr Leu Gly Glu Asp Tyr Val 
    210                 215                 220                 

Val Phe Ala Glu Ala Lys Gly Val Ser Lys Arg Arg Leu Ile Phe Ser 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Leu Leu Pro Gln Leu Thr Ser Val Ala Ile 
                245                 250                 255     

Ala Leu Ser Ser Ile Ile Gly Gly Gln Ile Leu Ile Glu Gln Val Phe 
            260                 265                 270         

Ser Tyr Pro Gly Ile Gly Tyr Gly Leu Thr Asn Ala Val Ala Ser Glu 
        275                 280                 285             

Asp Tyr Pro Leu Ile Gln Gly Met Phe Leu Ile Ile Ala Val Thr Ala 
    290                 295                 300                 

Leu Val Ile Asn Phe Ile Val Asp Met Leu Tyr Gly Arg Leu Asp Pro 
305                 310                 315                 320 

Arg Val Arg Arg Arg Gly Ala Ala 
                325             

<210>   529
<211>   987
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   529
atgcgatatt tcctaaatcg attttgtttt ctcgtcttgt cgctttgggc ggctatcacg       60

ctgaacttca tcctgccgcg cctcatgccc ggcaaccctg ctcaggcgat gatcgctaag      120

caggccggga atatcaatcc tgccgcactg aaagccattg aggagcagct cgggctgtca      180

aatggtcccc tgtggcagca gtattttcag tacctcggaa atctgttgac agggcactgg      240

ggcgcttcgt ttcagtactt tccgaccccg gtcgtcaaca tcattgagac gagcctgccg      300

tggaccatcg tgctgctcgg cgtggtgacc atcatctccg tggtcgtcgg aacgctcatc      360

ggcattctca tcgcctggcg ccgcggcgga accgcggaca acgtgatccc ggtagccacg      420

atgttcggcc aggccatccc gaccttctgg ctcggcctca ttctcatcta cttcttcggg      480

ttcgtgcatc actggtttcc gctcgcgcac ggatacggag acgacgtgac gccggggctc      540

aacgctccgt ttctggcgag cgcggtctac cacagcatcc tgccggcggt ggtggtgttc      600

gtcggcagca tcagcggctg gatcgtgggc atgcgcaaca acatgatcac gacgctcgga      660

gaggactatg tggtcttcgc cgaggccaaa ggggtatcga agcggaggct cattttttcg      720

tacgccgcgc gcaatgcgct cctgcctcag ttgacctccg tggccatcgc gctctcgtcg      780

atcatcggcg ggcaaattct cattgaacaa gtgttttcct acccaggcat cggatacggc      840

ctgaccaacg cggtggcgag tgaagactat ccgctcattc aagggatgtt tctcatcatt      900

gcggtgacag cgcttgtgat caacttcatt gtcgacatgc tgtacggacg gctcgatccg      960

cgcgtgcgta gaaggggggc ggcgtga                                          987


<210>   530
<211>   323
<212>   PRT
<213>   Arthrobacter sp. FB24

<400>   530
Met Arg Phe Ile Leu Arg Arg Leu Gly Phe Tyr Leu Ile Ala Phe Trp 
                5                   10                  15      

Val Ser Ile Thr Leu Asn Phe Leu Leu Pro Arg Phe Met Pro Gly Asp 
            20                  25                  30          

Pro Val Ser Arg Met Phe Ala Arg Thr Gln Asp Arg Met Gln Pro Glu 
        35                  40                  45              

Gln Ile Glu Ala Leu Arg Lys Leu Leu Gly Val Asp Asp Arg Pro Ile 
    50                  55                  60                  

Trp Glu Gln Tyr Val Asp Tyr Leu His Asn Met Val Thr Gly Gln Met 
65                  70                  75                  80  

Gly Val Ser Ile Ser Arg Phe Pro Thr Pro Val Thr Glu Val Ile Ala 
                85                  90                  95      

Ser Gln Val Gly Trp Thr Leu Leu Leu Gly Gly Thr Ala Leu Val Ile 
            100                 105                 110         

Ala Ala Val Val Gly Asn Leu Leu Gly Ile Leu Ala Ala Trp Arg Arg 
        115                 120                 125             

Gly Gly Ala Ile Asp Ser Ala Leu Pro Pro Ile Leu Ile Phe Ile Gly 
    130                 135                 140                 

Ser Phe Pro Tyr Phe Trp Leu Ala Met Gly Ala Leu Tyr Leu Phe Gly 
145                 150                 155                 160 

Val Thr Leu Gly Trp Phe Pro Ile Arg His Ala Phe Ser Asp Thr Ile 
                165                 170                 175     

Glu Pro Ser Phe Ser Trp Glu Phe Met Ser Asp Val Gly Met His Leu 
            180                 185                 190         

Val Leu Pro Ala Leu Thr Ile Val Leu Val Ser Val Gly Gly Trp Met 
        195                 200                 205             

Leu Gly Met Arg Asn Thr Met Ile Ala Thr Asn Ala Glu Asp Tyr Ile 
    210                 215                 220                 

Thr Met Ala Glu Ala Lys Gly Leu Arg Pro Gly Arg Ile Met Phe Arg 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Met Leu Pro Ser Val Thr Ser Phe Gly Met 
                245                 250                 255     

Ser Leu Gly Phe Val Val Gly Gly Ala Leu Leu Thr Glu Val Val Phe 
            260                 265                 270         

Ala Tyr Pro Gly Val Gly Tyr Gln Leu Leu Asn Ala Val Gln Gly Leu 
        275                 280                 285             

Asp Tyr Pro Leu Met Gln Gly Leu Phe Leu Thr Ile Thr Ala Ala Val 
    290                 295                 300                 

Leu Leu Ala Asn Phe Leu Val Asp Ile Leu Tyr Val Arg Leu Asp Pro 
305                 310                 315                 320 

Arg Val Arg 
            

<210>   531
<211>   323
<212>   PRT
<213>   Arthrobacter aurescens TC1

<400>   531
Met Arg Phe Ile Leu Arg Arg Leu Gly Phe Tyr Leu Ile Ala Phe Trp 
                5                   10                  15      

Ala Ser Ile Thr Leu Asn Phe Leu Leu Pro Arg Phe Met Pro Gly Asp 
            20                  25                  30          

Pro Val Ser Arg Met Phe Ala Arg Ser Gln Asp Arg Met Gln Pro Glu 
        35                  40                  45              

Gln Ile Glu Ala Leu Arg Lys Leu Leu Gly Val Asp Asp Arg Pro Ile 
    50                  55                  60                  

Trp Glu Gln Tyr Ile Asp Tyr Met His Asn Ile Phe Thr Gly Gln Met 
65                  70                  75                  80  

Gly Val Ser Ile Ser Arg Phe Pro Thr Pro Val Thr Glu Val Ile Ser 
                85                  90                  95      

Ala Gln Ile Gly Trp Thr Leu Leu Leu Gly Gly Thr Ala Leu Val Val 
            100                 105                 110         

Ala Ala Val Val Gly Asn Leu Leu Gly Ile Leu Ala Ala Trp Arg Arg 
        115                 120                 125             

Gly Gly Ala Ile Asp Ser Ala Leu Pro Pro Leu Leu Val Phe Ile Gly 
    130                 135                 140                 

Ser Phe Pro Tyr Phe Trp Leu Ala Met Gly Ala Leu Tyr Leu Phe Gly 
145                 150                 155                 160 

Val Val Leu Gly Trp Phe Pro Ile Arg His Ala Phe Thr Asp Gly Leu 
                165                 170                 175     

Glu Pro Ala Phe Thr Trp Glu Phe Ile Gly Asp Val Gly Ala His Leu 
            180                 185                 190         

Val Leu Pro Ala Leu Thr Ile Val Leu Val Ser Ile Gly Gly Trp Met 
        195                 200                 205             

Leu Gly Met Arg Asn Thr Met Ile Ala Thr Asn Ser Glu Asp Tyr Ile 
    210                 215                 220                 

Thr Met Ala Glu Ala Lys Gly Leu Arg Pro Gly Arg Ile Met Leu Arg 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Met Leu Pro Ser Val Thr Ser Phe Gly Met 
                245                 250                 255     

Gly Leu Gly Phe Val Val Gly Gly Ala Leu Leu Thr Glu Val Val Phe 
            260                 265                 270         

Ala Tyr Pro Gly Val Gly Tyr Gln Leu Leu Asn Ala Val Gln Gly Leu 
        275                 280                 285             

Asp Tyr Pro Leu Met Gln Gly Leu Phe Leu Thr Ile Thr Ala Ala Val 
    290                 295                 300                 

Leu Leu Ala Asn Phe Leu Val Asp Ile Leu Tyr Val Arg Leu Asp Pro 
305                 310                 315                 320 

Arg Val Arg 
            

<210>   532
<211>   326
<212>   PRT
<213>   Lactococcus lactis subsp. cremoris MG1363

<400>   532
Met Arg Phe Phe Ile Arg Arg Val Ala Phe Tyr Ile Val Thr Ala Trp 
                5                   10                  15      

Ala Ala Val Thr Leu Asn Phe Phe Ile Pro Arg Met Met Pro Gly Asp 
            20                  25                  30          

Pro Val Gln Ala Leu Ile Ala Arg Tyr Gln Gly Gln Ile Ser Val Asp 
        35                  40                  45              

Ala Val Asn Ser Leu Arg Lys Leu Phe Gly Met Asp Ala His Glu Ser 
    50                  55                  60                  

Leu Trp Gln Gln Tyr Ile Asp Tyr Trp Val Lys Leu Phe His Gly Asn 
65                  70                  75                  80  

Leu Gly Val Ser Leu Gln Ser Phe Pro Thr Pro Val Ser Gln Ile Ile 
                85                  90                  95      

Ser Gln Ser Leu Pro Trp Thr Ile Gly Leu Val Gly Leu Ala Thr Ile 
            100                 105                 110         

Ile Ala Phe Val Val Gly Thr Val Ile Gly Ile Ile Leu Gly Trp Arg 
        115                 120                 125             

Arg Gly Thr Lys Trp Asp Ala Leu Ile Pro Ile Thr Thr Phe Phe Ser 
    130                 135                 140                 

Ser Val Pro Tyr Phe Trp Ile Gly Leu Met Ala Ile Ala Ile Phe Ala 
145                 150                 155                 160 

Thr Val Leu Gln Trp Phe Pro Gln Gly Gly Ser Tyr Ser Val Asp Ser 
                165                 170                 175     

Leu Pro Gly Leu Asn Trp Ala Phe Met Ser Ser Val Phe Tyr Tyr Gly 
            180                 185                 190         

Phe Leu Pro Ala Leu Thr Ile Val Leu Ser Ser Met Ala Gly Trp Ile 
        195                 200                 205             

Leu Gly Met Arg Asn Met Met Val Thr Val Ser Ser Glu Asp Tyr Val 
    210                 215                 220                 

Thr Val Ala His Ala Lys Gly Leu Arg Glu Ser Val Val Met Phe Arg 
225                 230                 235                 240 

Tyr Ala Ser Arg Asn Ala Ile Leu Pro Gln Ile Ser Gly Phe Ala Leu 
                245                 250                 255     

Ser Leu Gly Phe Val Val Ser Gly Thr Leu Val Met Glu Gln Val Phe 
            260                 265                 270         

Asn Tyr Gln Gly Ile Gly Tyr Arg Leu Leu Gln Ala Thr Asn Asn His 
        275                 280                 285             

Asp Tyr Pro Leu Met Gln Gly Ile Phe Leu Val Ile Thr Leu Ser Val 
    290                 295                 300                 

Leu Ile Ala Asn Val Val Ala Asp Ile Ile Tyr Ala Phe Leu Asp Pro 
305                 310                 315                 320 

Arg Thr Arg Lys Glu Gly 
                325     

<210>   533
<211>   325
<212>   PRT
<213>   Sorangium cellulosum 'So ce 56'

<400>   533
Met Arg Tyr Leu Leu Arg Gln Leu Gly Leu Tyr Phe Ile Ala Ala Trp 
                5                   10                  15      

Ala Ser Leu Thr Leu Asn Phe Leu Ile Pro Arg Ala Met Pro Gly Asp 
            20                  25                  30          

Pro Ala Ser Ala Met Phe Val Arg Phe Arg Gly Gln Leu Gln Pro Glu 
        35                  40                  45              

Ala Ile Glu Ala Leu Arg Lys Ala Phe Gly Phe Thr Asp Glu Pro Leu 
    50                  55                  60                  

Tyr Lys Gln Tyr Phe Thr Tyr Leu Ser His Ile Leu Val Gly Asp Leu 
65                  70                  75                  80  

Gly Thr Ser Val Ala His Phe Pro Ala Lys Val Thr Glu Val Ile Ala 
                85                  90                  95      

Thr Gly Leu Gly Trp Thr Leu Leu Leu Ser Gly Ala Ala Val Ile Val 
            100                 105                 110         

Ser Phe Gly Leu Gly Thr Leu Leu Gly Ile Ile Ala Thr Trp Lys Arg 
        115                 120                 125             

Gly Gly Trp Leu Asp Ser Val Met Pro Pro Val Leu Met Phe Leu Gly 
    130                 135                 140                 

Ala Phe Pro Tyr Phe Trp Leu Ala Met Val Ser Leu Tyr Leu Leu Gly 
145                 150                 155                 160 

Phe Val Leu Gly Ala Phe Pro Leu Arg His Ala Tyr Ser Asp Thr Leu 
                165                 170                 175     

Ser Pro Glu Trp Ser Leu Glu Phe Ile Gly Ser Val Leu Ser His Met 
            180                 185                 190         

Ile Leu Pro Ala Leu Ser Ile Val Ile Ala Thr Ile Gly Gly Trp Met 
        195                 200                 205             

Leu Gly Met Arg Ser Ala Met Val Thr Val Leu Ser Glu Glu Tyr Ile 
    210                 215                 220                 

Thr Met Ala Gln Ala Lys Gly Leu Ser Gln Trp Arg Val Met Phe Thr 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Leu Leu Pro Asn Val Thr Gly Phe Gly Met 
                245                 250                 255     

Ala Leu Gly Phe Val Leu Ala Gly Ser Leu Leu Thr Glu Ile Val Phe 
            260                 265                 270         

Ser Tyr Pro Gly Gln Gly Tyr Leu Leu Ile Gln Ala Val Arg Asn Gln 
        275                 280                 285             

Asp Tyr Pro Leu Met Gln Gly Ile Phe Leu Thr Ile Thr Phe Ala Val 
    290                 295                 300                 

Leu Gly Ala Asn Phe Leu Val Asp Val Ile Tyr Val Phe Leu Asp Pro 
305                 310                 315                 320 

Arg Ala Arg Gly Arg 
                325 

<210>   534
<211>   325
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   534
Met Arg Phe Leu Leu Arg Arg Leu Gly Phe Tyr Ala Val Ala Ala Trp 
                5                   10                  15      

Val Ser Leu Thr Val Asn Phe Tyr Leu Pro Arg Leu Met Pro Gly Asp 
            20                  25                  30          

Pro Ala Ser Ala Ile Phe Ala Arg Phe Gln Gly Arg Leu Arg Pro Glu 
        35                  40                  45              

Glu Ile Asp Ser Leu Arg Lys Ala Tyr Gly Leu Ser Asp Ala Pro Leu 
    50                  55                  60                  

Leu Glu Gln Tyr Phe Asn Tyr Leu Arg Ser Leu Ser Arg Gly Glu Phe 
65                  70                  75                  80  

Gly Ile Ser Ile Asn Phe Phe Pro Ala Gln Val Thr Asp Val Ile Ser 
                85                  90                  95      

Thr Gly Phe Met Trp Thr Ile Leu Leu Ala Gly Leu Ala Thr Val Ile 
            100                 105                 110         

Ser Phe Phe Leu Gly Asn Val Leu Gly Ile Ile Gly Ala Trp Arg Arg 
        115                 120                 125             

Asn Gly Ile Leu Asp Ser Val Ala Pro Pro Leu Leu Thr Phe Ile Gly 
    130                 135                 140                 

Ala Phe Pro Tyr Phe Phe Leu Ala Met Ile Ala Leu Tyr Phe Leu Ala 
145                 150                 155                 160 

Phe Gln Ala Gly Trp Phe Pro Leu Arg His Ala Tyr Ser Asp Ala Leu 
                165                 170                 175     

Ser Val Asp Trp Gly Ser Leu Thr Phe Ile Lys Ser Val Ile Ser His 
            180                 185                 190         

Met Ile Leu Pro Ala Ser Cys Ile Val Leu Ala Ser Ile Gly Gly Trp 
        195                 200                 205             

Met Leu Gly Met Arg Asn Thr Met Val Gly Ile Leu Ser Glu Asp Tyr 
    210                 215                 220                 

Ile Thr Met Ala Gln Ala Lys Gly Leu Ser Gln Gln Arg Ile Met Phe 
225                 230                 235                 240 

Ser Tyr Ala Ala Arg Asn Ala Leu Leu Pro Asn Val Thr Ser Phe Gly 
                245                 250                 255     

Met Ala Leu Gly Phe Val Leu Ser Gly Ser Leu Leu Thr Glu Ile Ile 
            260                 265                 270         

Phe Ala Tyr Pro Gly Leu Gly Tyr Leu Leu Leu Gln Ala Val Arg Asn 
        275                 280                 285             

Leu Asp Tyr Pro Leu Met Gln Gly Leu Phe Leu Met Ile Thr Phe Ala 
    290                 295                 300                 

Val Leu Gly Ala Asn Leu Leu Val Asp Ile Leu Tyr Val Trp Leu Asp 
305                 310                 315                 320 

Pro Arg Thr Arg Arg 
                325 

<210>   535
<211>   328
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   535
Met Arg Tyr Phe Leu Asn Arg Phe Cys Phe Leu Val Leu Ser Leu Trp 
                5                   10                  15      

Ala Ala Leu Thr Leu Asn Phe Ile Leu Pro Arg Leu Met Pro Gly Asn 
            20                  25                  30          

Pro Ala Gln Ala Met Ile Ala Lys Gln Ala Gly Asn Ile Asn Pro Ala 
        35                  40                  45              

Ala Leu Lys Ala Ile Glu Glu Gln Leu Gly Leu Ser Asn Gly Pro Leu 
    50                  55                  60                  

Trp Gln Gln Tyr Phe Gln Tyr Leu Gly Asn Leu Leu Thr Gly His Trp 
65                  70                  75                  80  

Gly Ala Ser Phe Gln Tyr Phe Pro Thr Pro Val Val Asn Ile Ile Glu 
                85                  90                  95      

Thr Ser Leu Pro Trp Thr Ile Val Leu Leu Gly Val Val Thr Ile Ile 
            100                 105                 110         

Ser Val Val Val Gly Thr Leu Ile Gly Ile Leu Ile Ala Trp Arg Arg 
        115                 120                 125             

Gly Gly Thr Ala Asp Asn Val Ile Pro Val Ala Thr Met Phe Gly Gln 
    130                 135                 140                 

Ala Ile Pro Thr Phe Trp Leu Gly Leu Ile Leu Ile Tyr Phe Phe Gly 
145                 150                 155                 160 

Phe Val His His Trp Phe Pro Leu Ala His Gly Tyr Gly Asp Asp Val 
                165                 170                 175     

Thr Pro Gly Leu Asn Ala Pro Phe Leu Ala Ser Ala Val Tyr His Ser 
            180                 185                 190         

Ile Leu Pro Ala Val Val Val Phe Val Gly Ser Ile Ser Gly Trp Ile 
        195                 200                 205             

Val Gly Met Arg Asn Asn Met Ile Thr Thr Leu Gly Glu Asp Tyr Val 
    210                 215                 220                 

Val Phe Ala Glu Ala Lys Gly Val Ser Lys Arg Arg Leu Ile Phe Ser 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Leu Leu Pro Gln Leu Thr Ser Val Ala Ile 
                245                 250                 255     

Ala Leu Ser Ser Ile Ile Gly Gly Gln Ile Leu Ile Glu Gln Val Phe 
            260                 265                 270         

Ser Tyr Pro Gly Ile Gly Tyr Gly Leu Thr Asn Ala Val Ala Ser Glu 
        275                 280                 285             

Asp Tyr Pro Leu Ile Gln Gly Met Phe Leu Ile Ile Ala Val Thr Ala 
    290                 295                 300                 

Leu Val Ile Asn Phe Ile Val Asp Met Leu Tyr Gly Arg Leu Asp Pro 
305                 310                 315                 320 

Arg Val Arg Arg Arg Gly Ala Ala 
                325             

<210>   536
<211>   328
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   536
Met Arg Tyr Phe Leu Asn Arg Phe Cys Phe Leu Val Leu Ser Leu Trp 
                5                   10                  15      

Ala Ala Ile Thr Leu Asn Phe Ile Leu Pro Arg Leu Met Pro Gly Asn 
            20                  25                  30          

Pro Ala Gln Ala Met Ile Ala Lys Gln Ala Gly Asn Ile Asn Pro Ala 
        35                  40                  45              

Ala Leu Lys Ala Ile Glu Glu Gln Leu Gly Leu Ser Asn Gly Pro Leu 
    50                  55                  60                  

Trp Gln Gln Tyr Phe Gln Tyr Leu Gly Asn Leu Leu Thr Gly His Trp 
65                  70                  75                  80  

Gly Ala Ser Phe Gln Tyr Phe Pro Thr Pro Val Val Asn Ile Ile Glu 
                85                  90                  95      

Thr Ser Leu Pro Trp Thr Ile Val Leu Leu Gly Val Val Thr Ile Ile 
            100                 105                 110         

Ser Val Val Val Gly Thr Leu Ile Gly Ile Leu Ile Ala Trp Arg Arg 
        115                 120                 125             

Gly Gly Thr Ala Asp Asn Val Ile Pro Val Ala Thr Met Phe Gly Gln 
    130                 135                 140                 

Ala Ile Pro Thr Phe Trp Leu Gly Leu Ile Leu Ile Tyr Phe Phe Gly 
145                 150                 155                 160 

Phe Val His His Trp Phe Pro Leu Ala His Gly Tyr Gly Asp Asp Val 
                165                 170                 175     

Thr Pro Gly Leu Asn Ala Pro Phe Leu Ala Ser Ala Val Tyr His Ser 
            180                 185                 190         

Ile Leu Pro Ala Val Val Val Phe Val Gly Ser Ile Ser Gly Trp Ile 
        195                 200                 205             

Val Gly Met Arg Asn Asn Met Ile Thr Thr Leu Gly Glu Asp Tyr Val 
    210                 215                 220                 

Val Phe Ala Glu Ala Lys Gly Val Ser Lys Arg Arg Leu Ile Phe Ser 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Leu Leu Pro Gln Leu Thr Ser Ile Ala Ile 
                245                 250                 255     

Ala Leu Ser Ser Ile Ile Gly Gly Gln Ile Leu Ile Glu Gln Val Phe 
            260                 265                 270         

Ser Tyr Pro Gly Ile Gly Tyr Gly Leu Thr Asn Ala Val Ala Ser Glu 
        275                 280                 285             

Asp Tyr Pro Leu Ile Gln Gly Met Phe Leu Ile Ile Ala Val Thr Ala 
    290                 295                 300                 

Leu Val Ile Asn Phe Ile Val Asp Met Leu Tyr Gly Arg Leu Asp Pro 
305                 310                 315                 320 

Arg Val Arg Arg Arg Gly Ala Ala 
                325             

<210>   537
<211>   328
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   537
Met Arg Tyr Phe Leu Asn Arg Phe Cys Phe Ile Val Leu Ser Leu Trp 
                5                   10                  15      

Ala Ala Ile Thr Leu Asn Phe Ile Leu Pro Arg Leu Met Pro Gly Asn 
            20                  25                  30          

Pro Ala Gln Ala Met Ile Ala Lys Gln Ala Gly Asn Ile Asn Pro Ala 
        35                  40                  45              

Ala Leu Lys Ala Ile Glu Glu Gln Leu Gly Leu Ser Asn Gly Pro Leu 
    50                  55                  60                  

Trp Gln Gln Tyr Phe Gln Tyr Leu Gly Asn Leu Leu Thr Gly His Trp 
65                  70                  75                  80  

Gly Ala Ser Phe Gln Tyr Phe Pro Thr Pro Val Val Asn Ile Ile Glu 
                85                  90                  95      

Thr Ser Leu Pro Trp Thr Ile Val Leu Leu Gly Val Val Thr Ile Ile 
            100                 105                 110         

Ser Val Val Val Gly Thr Leu Ile Gly Ile Leu Ile Ala Trp Arg Arg 
        115                 120                 125             

Gly Gly Thr Ala Asp Asn Val Ile Pro Val Ala Thr Met Phe Gly Gln 
    130                 135                 140                 

Ala Ile Pro Thr Phe Trp Leu Gly Leu Ile Leu Ile Tyr Phe Phe Gly 
145                 150                 155                 160 

Phe Val His His Trp Phe Pro Leu Ala His Gly Tyr Gly Asp Asp Val 
                165                 170                 175     

Thr Pro Gly Leu Asn Ala Pro Phe Leu Ala Ser Ala Val Tyr His Ser 
            180                 185                 190         

Ile Leu Pro Ala Val Val Val Phe Val Gly Ser Ile Ser Gly Trp Ile 
        195                 200                 205             

Val Gly Met Arg Asn Asn Met Ile Thr Thr Leu Gly Glu Asp Tyr Val 
    210                 215                 220                 

Val Phe Ala Glu Ala Lys Gly Val Ser Lys Arg Arg Leu Ile Phe Ser 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Leu Leu Pro Gln Leu Thr Ser Val Ala Ile 
                245                 250                 255     

Ala Leu Ser Ser Ile Ile Gly Gly Gln Ile Leu Ile Glu Gln Val Phe 
            260                 265                 270         

Ser Tyr Pro Gly Ile Gly Tyr Gly Leu Thr Asn Ala Val Ala Ser Glu 
        275                 280                 285             

Asp Tyr Pro Leu Ile Gln Gly Met Phe Leu Ile Ile Ala Val Thr Ala 
    290                 295                 300                 

Leu Val Ile Asn Phe Ile Val Asp Met Leu Tyr Gly Arg Leu Asp Pro 
305                 310                 315                 320 

Arg Val Arg Arg Arg Gly Ala Ala 
                325             

<210>   538
<211>   328
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   538
Met Arg Tyr Phe Leu Gln Arg Phe Cys Phe Leu Val Leu Ser Leu Trp 
                5                   10                  15      

Ala Ala Ile Thr Leu Asn Phe Ile Leu Pro Arg Leu Met Pro Gly Asn 
            20                  25                  30          

Pro Ala Gln Ala Met Ile Ala Lys Gln Ala Gly Asn Ile Asn Pro Ala 
        35                  40                  45              

Ala Leu Lys Ala Ile Glu Glu Gln Leu Gly Leu Ser Asn Gly Pro Leu 
    50                  55                  60                  

Trp Gln Gln Tyr Phe Gln Tyr Leu Gly Asn Leu Leu Thr Gly His Trp 
65                  70                  75                  80  

Gly Ala Ser Phe Gln Tyr Phe Pro Thr Pro Val Val Asn Ile Ile Glu 
                85                  90                  95      

Thr Ser Leu Pro Trp Thr Ile Val Leu Leu Gly Val Val Thr Ile Ile 
            100                 105                 110         

Ser Val Val Val Gly Thr Leu Ile Gly Ile Leu Ile Ala Trp Arg Arg 
        115                 120                 125             

Gly Gly Thr Ala Asp Asn Val Ile Pro Val Ala Thr Met Phe Gly Gln 
    130                 135                 140                 

Ala Ile Pro Thr Phe Trp Leu Gly Leu Ile Leu Ile Tyr Phe Phe Gly 
145                 150                 155                 160 

Phe Val His His Trp Phe Pro Leu Ala His Gly Tyr Gly Asp Asp Val 
                165                 170                 175     

Thr Pro Gly Leu Asn Ala Pro Phe Leu Ala Ser Ala Val Tyr His Ser 
            180                 185                 190         

Ile Leu Pro Ala Val Val Val Phe Val Gly Ser Ile Ser Gly Trp Ile 
        195                 200                 205             

Val Gly Met Arg Asn Asn Met Ile Thr Thr Leu Gly Glu Asp Tyr Val 
    210                 215                 220                 

Val Phe Ala Glu Ala Lys Gly Val Ser Lys Arg Arg Leu Ile Phe Ser 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Leu Leu Pro Gln Leu Thr Ser Val Ala Ile 
                245                 250                 255     

Ala Leu Ser Ser Ile Ile Gly Gly Gln Ile Leu Ile Glu Gln Val Phe 
            260                 265                 270         

Ser Tyr Pro Gly Ile Gly Tyr Gly Leu Thr Asn Ala Val Ala Ser Glu 
        275                 280                 285             

Asp Tyr Pro Leu Ile Gln Gly Met Phe Leu Ile Ile Ala Val Thr Ala 
    290                 295                 300                 

Leu Val Ile Asn Phe Ile Val Asp Met Leu Tyr Gly Arg Leu Asp Pro 
305                 310                 315                 320 

Arg Val Arg Arg Arg Gly Ala Ala 
                325             

<210>   539
<211>   328
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 528

<400>   539
Met Arg Tyr Phe Leu Asn Arg Phe Cys Phe Leu Val Leu Ser Leu Trp 
                5                   10                  15      

Ala Ala Ile Thr Leu Asn Phe Ile Leu Pro Arg Leu Met Pro Gly Asn 
            20                  25                  30          

Pro Ala Gln Ala Met Ile Ala Lys Gln Ala Gly Asn Ile Asn Pro Ala 
        35                  40                  45              

Ala Leu Lys Ala Ile Glu Glu Gln Leu Gly Leu Ser Asn Gly Pro Leu 
    50                  55                  60                  

Trp Gln Gln Tyr Phe Gln Tyr Leu Gly Asn Leu Leu Thr Gly His Trp 
65                  70                  75                  80  

Gly Ala Ser Phe Gln Tyr Phe Pro Thr Pro Val Val Asn Ile Ile Glu 
                85                  90                  95      

Thr Ser Leu Pro Trp Thr Ile Val Leu Leu Gly Val Val Thr Ile Ile 
            100                 105                 110         

Ser Val Ile Val Gly Thr Leu Ile Gly Ile Leu Ile Ala Trp Arg Arg 
        115                 120                 125             

Gly Gly Thr Ala Asp Asn Val Ile Pro Val Ala Thr Met Phe Gly Gln 
    130                 135                 140                 

Ala Ile Pro Thr Phe Trp Leu Gly Leu Ile Leu Ile Tyr Phe Phe Gly 
145                 150                 155                 160 

Phe Val His His Trp Phe Pro Leu Ala His Gly Tyr Gly Asp Asp Val 
                165                 170                 175     

Thr Pro Gly Leu Asn Ala Pro Phe Leu Ala Ser Ala Val Tyr His Ser 
            180                 185                 190         

Ile Leu Pro Ala Val Val Val Phe Val Gly Ser Ile Ser Gly Trp Ile 
        195                 200                 205             

Val Gly Met Arg Asn Asn Met Ile Thr Thr Leu Gly Glu Asp Tyr Val 
    210                 215                 220                 

Val Phe Ala Glu Ala Lys Gly Val Ser Lys Arg Arg Leu Ile Phe Ser 
225                 230                 235                 240 

Tyr Ala Ala Arg Asn Ala Leu Leu Pro Gln Leu Thr Ser Val Ala Ile 
                245                 250                 255     

Ala Leu Ser Ser Ile Ile Gly Gly Gln Ile Leu Ile Glu Gln Val Phe 
            260                 265                 270         

Ser Tyr Pro Gly Ile Gly Tyr Gly Leu Thr Asn Ala Val Ala Ser Glu 
        275                 280                 285             

Asp Tyr Pro Leu Ile Gln Gly Met Phe Leu Ile Ile Ala Val Thr Ala 
    290                 295                 300                 

Leu Val Ile Asn Phe Ile Val Asp Met Leu Tyr Gly Arg Leu Asp Pro 
305                 310                 315                 320 

Arg Val Arg Arg Arg Gly Ala Ala 
                325             

<210>   540
<211>   987
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   540
atgcgatatt tcctaaatcg attttgtttt ctcgtcttgt cgctttgggc ggctttaacg       60

ctgaacttca tcctgccgcg cctcatgccc ggcaaccctg ctcaggcgat gatcgctaag      120

caggccggga atatcaatcc tgccgcactg aaagccattg aggagcagct cgggctgtca      180

aatggtcccc tgtggcagca gtattttcag tacctcggaa atctgttgac agggcactgg      240

ggcgcttcgt ttcagtactt tccgaccccg gtcgtcaaca tcattgagac gagcctgccg      300

tggaccatcg tgctgctcgg cgtggtgacc atcatctccg tggtcgtcgg aacgctcatc      360

ggcattctca tcgcctggcg ccgcggcgga accgcggaca acgtgatccc ggtagccacg      420

atgttcggcc aggccatccc gaccttctgg ctcggcctca ttctcatcta cttcttcggg      480

ttcgtgcatc actggtttcc gctcgcgcac ggatacggag acgacgtgac gccggggctc      540

aacgctccgt ttctggcgag cgcggtctac cacagcatcc tgccggcggt ggtggtgttc      600

gtcggcagca tcagcggctg gatcgtgggc atgcgcaaca acatgatcac gacgctcgga      660

gaggactatg tggtcttcgc cgaggccaaa ggggtatcga agcggaggct cattttttcg      720

tacgccgcgc gcaatgcgct cctgcctcag ttgacctccg tggccatcgc gctctcgtcg      780

atcatcggcg ggcaaattct cattgaacaa gtgttttcct acccaggcat cggatacggc      840

ctgaccaacg cggtggcgag tgaagactat ccgctcattc aagggatgtt tctcatcatt      900

gcggtgacag cgcttgtgat caacttcatt gtcgacatgc tgtacggacg gctcgatccg      960

cgcgtgcgta gaaggggggc ggcgtga                                          987


<210>   541
<211>   987
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   541
atgcgatatt tcctaaatcg attttgtttt ctcgtcttgt cgctttgggc ggctatcacg       60

ctgaacttca tcctgccgcg cctcatgccc ggcaaccctg ctcaggcgat gatcgctaag      120

caggccggga atatcaatcc tgccgcactg aaagccattg aggagcagct cgggctgtca      180

aatggtcccc tgtggcagca gtattttcag tacctcggaa atctgttgac agggcactgg      240

ggcgcttcgt ttcagtactt tccgaccccg gtcgtcaaca tcattgagac gagcctgccg      300

tggaccatcg tgctgctcgg cgtggtgacc atcatctccg tggtcgtcgg aacgctcatc      360

ggcattctca tcgcctggcg ccgcggcgga accgcggaca acgtgatccc ggtagccacg      420

atgttcggcc aggccatccc gaccttctgg ctcggcctca ttctcatcta cttcttcggg      480

ttcgtgcatc actggtttcc gctcgcgcac ggatacggag acgacgtgac gccggggctc      540

aacgctccgt ttctggcgag cgcggtctac cacagcatcc tgccggcggt ggtggtgttc      600

gtcggcagca tcagcggctg gatcgtgggc atgcgcaaca acatgatcac gacgctcgga      660

gaggactatg tggtcttcgc cgaggccaaa ggggtatcga agcggaggct cattttttcg      720

tacgccgcgc gcaatgcgct cctgcctcag ttgacctcca ttgccatcgc gctctcgtcg      780

atcatcggcg ggcaaattct cattgaacaa gtgttttcct acccaggcat cggatacggc      840

ctgaccaacg cggtggcgag tgaagactat ccgctcattc aagggatgtt tctcatcatt      900

gcggtgacag cgcttgtgat caacttcatt gtcgacatgc tgtacggacg gctcgatccg      960

cgcgtgcgta gaaggggggc ggcgtga                                          987


<210>   542
<211>   987
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   542
atgcgatatt tcctaaatcg attttgtttt attgtcttgt cgctttgggc ggctatcacg       60

ctgaacttca tcctgccgcg cctcatgccc ggcaaccctg ctcaggcgat gatcgctaag      120

caggccggga atatcaatcc tgccgcactg aaagccattg aggagcagct cgggctgtca      180

aatggtcccc tgtggcagca gtattttcag tacctcggaa atctgttgac agggcactgg      240

ggcgcttcgt ttcagtactt tccgaccccg gtcgtcaaca tcattgagac gagcctgccg      300

tggaccatcg tgctgctcgg cgtggtgacc atcatctccg tggtcgtcgg aacgctcatc      360

ggcattctca tcgcctggcg ccgcggcgga accgcggaca acgtgatccc ggtagccacg      420

atgttcggcc aggccatccc gaccttctgg ctcggcctca ttctcatcta cttcttcggg      480

ttcgtgcatc actggtttcc gctcgcgcac ggatacggag acgacgtgac gccggggctc      540

aacgctccgt ttctggcgag cgcggtctac cacagcatcc tgccggcggt ggtggtgttc      600

gtcggcagca tcagcggctg gatcgtgggc atgcgcaaca acatgatcac gacgctcgga      660

gaggactatg tggtcttcgc cgaggccaaa ggggtatcga agcggaggct cattttttcg      720

tacgccgcgc gcaatgcgct cctgcctcag ttgacctccg tggccatcgc gctctcgtcg      780

atcatcggcg ggcaaattct cattgaacaa gtgttttcct acccaggcat cggatacggc      840

ctgaccaacg cggtggcgag tgaagactat ccgctcattc aagggatgtt tctcatcatt      900

gcggtgacag cgcttgtgat caacttcatt gtcgacatgc tgtacggacg gctcgatccg      960

cgcgtgcgta gaaggggggc ggcgtga                                          987


<210>   543
<211>   987
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   543
atgcgatatt tcctacaacg attttgtttt ctcgtcttgt cgctttgggc ggctatcacg       60

ctgaacttca tcctgccgcg cctcatgccc ggcaaccctg ctcaggcgat gatcgctaag      120

caggccggga atatcaatcc tgccgcactg aaagccattg aggagcagct cgggctgtca      180

aatggtcccc tgtggcagca gtattttcag tacctcggaa atctgttgac agggcactgg      240

ggcgcttcgt ttcagtactt tccgaccccg gtcgtcaaca tcattgagac gagcctgccg      300

tggaccatcg tgctgctcgg cgtggtgacc atcatctccg tggtcgtcgg aacgctcatc      360

ggcattctca tcgcctggcg ccgcggcgga accgcggaca acgtgatccc ggtagccacg      420

atgttcggcc aggccatccc gaccttctgg ctcggcctca ttctcatcta cttcttcggg      480

ttcgtgcatc actggtttcc gctcgcgcac ggatacggag acgacgtgac gccggggctc      540

aacgctccgt ttctggcgag cgcggtctac cacagcatcc tgccggcggt ggtggtgttc      600

gtcggcagca tcagcggctg gatcgtgggc atgcgcaaca acatgatcac gacgctcgga      660

gaggactatg tggtcttcgc cgaggccaaa ggggtatcga agcggaggct cattttttcg      720

tacgccgcgc gcaatgcgct cctgcctcag ttgacctccg tggccatcgc gctctcgtcg      780

atcatcggcg ggcaaattct cattgaacaa gtgttttcct acccaggcat cggatacggc      840

ctgaccaacg cggtggcgag tgaagactat ccgctcattc aagggatgtt tctcatcatt      900

gcggtgacag cgcttgtgat caacttcatt gtcgacatgc tgtacggacg gctcgatccg      960

cgcgtgcgta gaaggggggc ggcgtga                                          987


<210>   544
<211>   987
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 529

<400>   544
atgcgatatt tcctaaatcg attttgtttt ctcgtcttgt cgctttgggc ggctatcacg       60

ctgaacttca tcctgccgcg cctcatgccc ggcaaccctg ctcaggcgat gatcgctaag      120

caggccggga atatcaatcc tgccgcactg aaagccattg aggagcagct cgggctgtca      180

aatggtcccc tgtggcagca gtattttcag tacctcggaa atctgttgac agggcactgg      240

ggcgcttcgt ttcagtactt tccgaccccg gtcgtcaaca tcattgagac gagcctgccg      300

tggaccatcg tgctgctcgg cgtggtgacc atcatctccg tgattgtcgg aacgctcatc      360

ggcattctca tcgcctggcg ccgcggcgga accgcggaca acgtgatccc ggtagccacg      420

atgttcggcc aggccatccc gaccttctgg ctcggcctca ttctcatcta cttcttcggg      480

ttcgtgcatc actggtttcc gctcgcgcac ggatacggag acgacgtgac gccggggctc      540

aacgctccgt ttctggcgag cgcggtctac cacagcatcc tgccggcggt ggtggtgttc      600

gtcggcagca tcagcggctg gatcgtgggc atgcgcaaca acatgatcac gacgctcgga      660

gaggactatg tggtcttcgc cgaggccaaa ggggtatcga agcggaggct cattttttcg      720

tacgccgcgc gcaatgcgct cctgcctcag ttgacctccg tggccatcgc gctctcgtcg      780

atcatcggcg ggcaaattct cattgaacaa gtgttttcct acccaggcat cggatacggc      840

ctgaccaacg cggtggcgag tgaagactat ccgctcattc aagggatgtt tctcatcatt      900

gcggtgacag cgcttgtgat caacttcatt gtcgacatgc tgtacggacg gctcgatccg      960

cgcgtgcgta gaaggggggc ggcgtga                                          987


<210>   545
<211>   331
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   545
Met Thr Val Ala Ala Ile Asp Val Val Asp Pro Arg Ala Lys Arg Ala 
                5                   10                  15      

Ser Arg Arg Arg Asn Ser Ala Leu Arg Gln Phe Phe Arg Asn Pro Lys 
            20                  25                  30          

Ala Leu Ala Gly Val Val Leu Phe Gly Met Phe Leu Val Val Ala Ile 
        35                  40                  45              

Phe Ala Pro Ala Ile Ala Pro Tyr Asn Pro Thr Ser Thr Ala Phe Gly 
    50                  55                  60                  

Met Leu Gln Pro Pro Ser His Ala His Trp Phe Gly Thr Thr Ser Leu 
65                  70                  75                  80  

Gly Gln Asp Val Phe Ser Gln Phe Ile Trp Gly Thr Arg Thr Thr Leu 
                85                  90                  95      

Ile Val Gly Val Gly Ala Gly Leu Leu Ser Thr Val Ile Ala Ile Leu 
            100                 105                 110         

Ile Gly Val Thr Ala Gly Tyr Val Gly Gly Val Val Asp Ser Ile Leu 
        115                 120                 125             

Asn Ala Leu Cys Asn Ile Phe Leu Val Met Pro Gly Leu Ala Leu Leu 
    130                 135                 140                 

Ile Ile Ile Glu Ser Tyr Val His Asn Thr Thr Pro Tyr Met Asn Gly 
145                 150                 155                 160 

Leu Ile Ile Ala Leu Thr Gly Trp Ala Trp Gly Ala Arg Val Met Arg 
                165                 170                 175     

Ser Met Ala Met Thr Ile Ala Ser Arg Asp Tyr Ile Ala Ala Ala Arg 
            180                 185                 190         

Leu Ser Gly Met Ser Thr Phe Arg Ile Ile Leu Phe Glu Ile Val Pro 
        195                 200                 205             

Asn Met Thr Ser Val Ile Ala Ser Asn Val Met Tyr Ala Cys Leu Ala 
    210                 215                 220                 

Ala Val Leu Ala Glu Ser Gly Leu Ala Tyr Leu Gly Phe Glu Asn Val 
225                 230                 235                 240 

Ala Ser Thr Ser Trp Gly Thr Met Leu Tyr Trp Ala Thr Gln Asn Ser 
                245                 250                 255     

Ala Leu Met Ser Gly Ala Trp Trp Trp Phe Val Pro Pro Gly Leu Gly 
            260                 265                 270         

Ile Ala Leu Leu Gly Thr Ser Phe Ala Leu Met Asn Phe Gly Ile Asp 
        275                 280                 285             

Gln Val Thr Asn Pro Arg Leu Arg Thr Ser Arg Arg Arg Arg Gln Val 
    290                 295                 300                 

Glu Lys Leu Leu Arg Glu Leu Arg Ala Gln Asn Gly Glu Val Lys Ala 
305                 310                 315                 320 

Asp Gly Arg Asp Ala Arg Thr Gly Ala Ser Asp 
                325                 330     

<210>   546
<211>   996
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   546
atgacagtcg cagccatcga tgtggtggat ccgcgcgcga agcgggcgag caggcgcaga       60

aactcggcgt tgcgccagtt ctttcgaaat ccgaaggcgc tcgcgggcgt cgtcctgttt      120

ggcatgtttc tggtggtggc catttttgcg cctgccatcg cgccctacaa tccaacttcc      180

acggcgtttg gcatgctgca acctccgtcg cacgcgcact ggttcggcac gacgagcctt      240

ggccaggacg tgttttcaca gttcatctgg ggcacgcgga ccacgctcat cgtgggcgtc      300

ggagcggggc ttttgagcac cgtgatcgcc atcctgatcg gcgtgacggc agggtatgtc      360

ggcggcgtgg tcgattcaat cctaaacgcg ctctgtaaca ttttcctcgt catgccggga      420

ttggcgctgc tcatcatcat cgaatcgtac gtgcacaaca cgacgccgta tatgaacggt      480

ctgatcatcg cgctgacggg ctgggcgtgg ggcgcgcgcg tgatgcggtc catggccatg      540

accattgcga gccgggatta catcgcggcg gcgcgcctgt cggggatgtc gacgttccgc      600

atcatcctgt tcgagatcgt gccgaacatg acgagcgtca ttgcctccaa cgtgatgtac      660

gcctgtctgg cggcggtgct cgcggagtcg ggcctcgcgt atctcgggtt cgaaaatgtg      720

gcctcgacga gctggggcac gatgctgtac tgggcgacgc agaacagcgc gctgatgagc      780

ggggcgtggt ggtggttcgt gccgccgggg ctcggcatcg cgcttctcgg cacgagcttt      840

gccctgatga acttcggcat cgaccaggtc accaacccgc gtctgcgcac gtcgcgcagg      900

cgtcgacagg tcgagaaact gctgcgcgag cttcgggcgc agaacggtga ggtgaaggcg      960

gatggcagag acgcgagaac cggtgcttca gattga                                996


<210>   547
<211>   267
<212>   PRT
<213>   Lactococcus lactis subsp. cremoris MG1363

<400>   547
Phe Leu Arg Asn Thr Lys Ser Ile Ile Gly Leu Ser Ile Phe Thr Phe 
                5                   10                  15      

Phe Ile Leu Val Ala Ile Phe Gly Pro Leu Leu Ala Pro Phe Asp Pro 
            20                  25                  30          

Asn Lys Thr Ser Ala Leu Ala Asn Ala Ala Pro Ser Thr Gln His Trp 
        35                  40                  45              

Leu Gly Thr Thr Asn Val Gly Gln Asp Ile Phe Ser Gln Ile Ile Ile 
    50                  55                  60                  

Gly Thr Arg Gly Val Met Val Val Ser Leu Ser Thr Gly Leu Ile Ala 
65                  70                  75                  80  

Thr Val Leu Ala Ala Val Ile Gly Val Ser Ala Gly Phe Leu Ser Gly 
                85                  90                  95      

Trp Gly Asp Glu Ile Leu Ser Met Leu Thr Asn Ile Phe Leu Val Ile 
            100                 105                 110         

Pro Gly Leu Pro Leu Ile Ile Ile Ile Met Gly Thr Met Thr Asn Ala 
        115                 120                 125             

Gly Leu Ala Ala Ile Val Leu Val Ile Ser Phe Thr Gly Trp Ala Trp 
    130                 135                 140                 

Gly Ala Arg Val Leu Arg Ser Gln Thr Met Ser Leu Arg Thr Arg Asp 
145                 150                 155                 160 

Phe Val Glu Ala Ala Arg Ala Ser Gly Glu Ser Arg Leu Arg Ile Ile 
                165                 170                 175     

Ile Phe Glu Ile Leu Pro Asn Leu Thr Ala Ile Leu Ala Ser Thr Phe 
            180                 185                 190         

Ile Gly Thr Val Thr Ala Ala Ile Met Ser Leu Val Thr Leu Ser Tyr 
        195                 200                 205             

Ile Gly Ile Ile Pro Pro Ser Asp Trp Ser Trp Gly Thr Val Leu Tyr 
    210                 215                 220                 

Tyr Ala Gln Asn Asn Gly Ala Phe Thr Ser Gly Gln Trp Trp Trp Tyr 
225                 230                 235                 240 

Ala Pro Ala Gly Leu Cys Val Ala Phe Leu Gly Met Ser Leu Ala Leu 
                245                 250                 255     

Ile Asn Phe Gly Ile Asp Glu Phe Val Asn Pro 
            260                 265         

<210>   548
<211>   264
<212>   PRT
<213>   Petrotoga mobilis SJ95

<400>   548
Asn Lys Lys Ala Ile Val Gly Leu Ser Ile Ile Leu Phe Phe Val Ile 
                5                   10                  15      

Val Ala Val Phe Ala Pro Phe Phe Ala Pro Tyr Asn Pro Asn Asp Phe 
            20                  25                  30          

Val Gly Pro Pro Tyr Ser Gln Pro Thr Phe Asn His Pro Leu Gly Leu 
        35                  40                  45              

Asp Arg Met Gly Arg Asp Ile Leu Ser Gln Leu Ile Tyr Gly Thr Arg 
    50                  55                  60                  

Leu Ser Leu Ile Val Gly Leu Ser Thr Gly Ala Leu Met Thr Ser Ile 
65                  70                  75                  80  

Ser Ile Leu Ile Gly Met Thr Ala Gly Tyr Phe Gly Gly Leu Val Asp 
                85                  90                  95      

Arg Ile Leu Ser Thr Ile Ile Asp Val Phe Met Val Ile Pro Gly Leu 
            100                 105                 110         

Pro Leu Met Ile Val Ile Ala Ser Tyr Ile Arg Ile Arg Gly Val Val 
        115                 120                 125             

Pro Ile Ile Leu Val Ile Ala Phe Thr Ser Trp Ala Pro Gly Ala Arg 
    130                 135                 140                 

Val Ile Arg Ser Gln Thr Leu Thr Met Arg Gly Arg Glu Phe Ile Leu 
145                 150                 155                 160 

Ala Ser Lys Ile Thr Gly Glu Lys Ser Gly Arg Ile Ile Phe Ser Glu 
                165                 170                 175     

Ile Met Pro Asn Met Phe Ser Leu Leu Ser Ser Asn Phe Phe Met Ala 
            180                 185                 190         

Cys Leu Thr Ala Ile Val Gly Glu Ala Ser Leu Glu Phe Leu Gly Phe 
        195                 200                 205             

Gly Asp Val Ser Ser Ile Thr Trp Gly Thr Met Leu Tyr Trp Ala Gln 
    210                 215                 220                 

Asn Ser Ser Ala Leu Leu Asn Asn Ser Trp Gly Trp Val Leu Ala Pro 
225                 230                 235                 240 

Gly Ala Ala Ile Ala Thr Leu Gly Ala Ser Phe Ala Leu Leu Asn Phe 
                245                 250                 255     

Ser Ile Asp Glu Ile Thr Asn Pro 
            260                 

<210>   549
<211>   294
<212>   PRT
<213>   Silicibacter sp. TM1040

<400>   549
Phe Leu Arg Asn Arg Lys Ala Ala Ile Gly Leu Thr Ile Val Leu Ile 
                5                   10                  15      

Tyr Val Ala Ile Ala Ile Ala Ala Pro Leu Ile Ala Pro Phe Asp Pro 
            20                  25                  30          

Ile Ala Arg Val Gly Arg Pro His Gln Pro Pro Ser Val Glu His Trp 
        35                  40                  45              

Leu Gly Thr Thr Arg Met Gly Arg Asp Val Phe Ser Gln Leu Val Trp 
    50                  55                  60                  

Gly Thr Arg Thr Ser Leu Met Val Gly Ile Val Ala Gly Leu Ile Val 
65                  70                  75                  80  

Thr Ala Ile Gly Thr Phe Ile Gly Ile Thr Ala Ala Tyr Phe Gly Gly 
                85                  90                  95      

Leu Val Asp Asp Ile Leu Asn Phe Phe Thr Asn Val Val Leu Val Leu 
            100                 105                 110         

Pro Gln Leu Pro Leu Leu Leu Val Leu Ala Ala Phe Leu Gly Gln Val 
        115                 120                 125             

Gly Pro Trp Ala Ile Ala Leu Ile Ile Gly Leu Thr Ser Trp Ala Trp 
    130                 135                 140                 

Gly Ala Arg Val Thr Arg Ala Gln Ala Met Ser Leu Lys Thr Arg Asp 
145                 150                 155                 160 

Phe Ile Gln Ala Ser Ala Met Ile Gly Glu Pro Thr Trp Arg Met Ile 
                165                 170                 175     

Leu Val Glu Met Leu Pro Asn Leu Leu Ser Ile Ile Gly Phe Asn Phe 
            180                 185                 190         

Ile Gly Ser Val Ile Phe Thr Ile Ile Thr Glu Ala Thr Leu Glu Phe 
        195                 200                 205             

Leu Gly Leu Gly Ser Pro Leu Ala Leu Ser Trp Gly Thr Met Leu Tyr 
    210                 215                 220                 

Asn Ala Gln Thr Ala Ser Ala Ile Met Val Gly Ala Trp Trp Glu Val 
225                 230                 235                 240 

Leu Ala Pro Cys Ala Ala Ile Val Leu Ile Gly Val Gly Leu Ser Leu 
                245                 250                 255     

Met Asn Phe Gly Val Asp Glu Ile Ala Asn Pro Arg Met Arg Thr Leu 
            260                 265                 270         

Gly Asn Val Ala Lys Ala Leu Arg Ile Glu Lys Arg Leu Leu Arg Gln 
        275                 280                 285             

Arg Met Gln Glu Ala Glu 
    290                 

<210>   550
<211>   257
<212>   PRT
<213>   Thermotoga lettingae TMO

<400>   550
Ala Gly Ile Ile Leu Phe Phe Leu Thr Ile Ala Leu Leu Ala Pro Tyr 
                5                   10                  15      

Ile Ala Pro Tyr Asn Pro Asn Asp Ile Val Asp Leu Pro Tyr Glu Lys 
            20                  25                  30          

Pro Ser Lys Leu His Phe Leu Gly Thr Asp Arg Leu Gly Arg Asp Ile 
        35                  40                  45              

Phe Ser Gln Leu Ile His Gly Thr Arg Leu Ser Leu Leu Ile Gly Ile 
    50                  55                  60                  

Leu Thr Gly Phe Leu Met Thr Gly Ile Ser Thr Phe Phe Gly Met Thr 
65                  70                  75                  80  

Ser Gly Tyr Tyr Gly Gly Ile Val Asp Arg Ile Leu Ser Thr Ile Thr 
                85                  90                  95      

Asp Val Phe Leu Val Ile Pro Gly Ile Pro Leu Met Ile Val Ile Ser 
            100                 105                 110         

Ser Tyr Ile Arg Val Arg Ser Phe Trp Thr Val Ile Ile Val Ile Ala 
        115                 120                 125             

Leu Thr Gly Trp Gly Gly Gly Ala Arg Val Ile Arg Ser Gln Met Leu 
    130                 135                 140                 

Ser Met Lys Asn Arg Glu Phe Val Thr Ala Ala Lys Ile Ile Gly Glu 
145                 150                 155                 160 

Lys Asn Ile Arg Ile Val Phe Phe Glu Ile Phe Pro Asn Met Leu Ser 
                165                 170                 175     

Leu Ile Ala Ser Asn Phe Phe Gly Ser Val Leu Tyr Ala Ile Ile Gly 
            180                 185                 190         

Glu Ala Ser Leu Ser Phe Leu Gly Leu Gly Asp Val Ser Arg Ile Ser 
        195                 200                 205             

Trp Gly Thr Met Leu Tyr Trp Ala Gln Ser Ala Asn Ala Leu Leu Asn 
    210                 215                 220                 

Gly Met Trp Ala Trp Val Leu Ala Pro Gly Leu Ser Ile Val Leu Leu 
225                 230                 235                 240 

Gly Thr Ala Phe Ala Leu Leu Asn Phe Ser Leu Asp Glu Met Thr Asn 
                245                 250                 255     

Pro 
    

<210>   551
<211>   266
<212>   PRT
<213>   Leifsonia xyli subsp. xyli str. CTCB07

<400>   551
Trp Arg Asp Pro Lys Cys Arg Val Gly Met Phe Leu Leu Ala Ala Phe 
                5                   10                  15      

Leu Leu Ala Ala Ala Leu Ala Pro Leu Ile Ala Pro Phe Asp Pro Arg 
            20                  25                  30          

Glu Ala Val Gly Gly Ala Ser Glu Gly Pro Ser Ala Ala His Trp Leu 
        35                  40                  45              

Gly Thr Thr Asp Asn Gly Glu Asp Val Leu Ser Gln Leu Ile Trp Gly 
    50                  55                  60                  

Ala Gln Thr Ser Leu Ile Val Gly Leu Ile Ala Gly Leu Ile Ser Thr 
65                  70                  75                  80  

Ala Ile Gly Leu Val Ile Gly Leu Thr Ala Gly Tyr Ser Gln Gly Val 
                85                  90                  95      

Val Asp Glu Ile Leu Ser Phe Leu Thr Asn Leu Ala Leu Val Val Pro 
            100                 105                 110         

Val Leu Pro Leu Ile Val Thr Leu Ala Ser Tyr Ser Pro Val Arg Gly 
        115                 120                 125             

Ile Trp Met Ile Ile Phe Val Ile Ser Val Thr Gly Trp Ala Tyr Gly 
    130                 135                 140                 

Ala Arg Ile Lys Arg Ser Gln Val Ile Ser Leu Arg Thr Arg Asp Tyr 
145                 150                 155                 160 

Val Ala Ala Glu Lys Leu Ala Gly Asp Arg Thr Pro Arg Ile Ile Leu 
                165                 170                 175     

Arg Glu Ile Met Pro Asn Met Thr Ser Leu Ile Val Val Ser Phe Met 
            180                 185                 190         

Gly Ala Ala Leu Gly Ala Ile Gly Gly Glu Gly Gly Leu Ala Phe Leu 
        195                 200                 205             

Gly Leu Gly Asp Pro Gln Thr Val Ser Trp Gly Ala Met Leu Tyr Gln 
    210                 215                 220                 

Ala Asn Ile Gly Gly Ala Leu Leu Thr Gly Gln Leu Ala Trp Leu Ile 
225                 230                 235                 240 

Ala Pro Gly Leu Thr Leu Ala Leu Leu Ile Thr Ser Phe Thr Leu Ile 
                245                 250                 255     

Asn Phe Gly Ile Asp Thr Leu Ser Asn Pro 
            260                 265     

<210>   552
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   552
Met Thr Val Ala Ala Ile Asp Val Val Asp Pro Arg Ala Lys Arg Ala 
                5                   10                  15      

Ser Arg Arg Arg Asn Ser Ala Leu Arg Gln Phe Phe Arg Asn Pro Lys 
            20                  25                  30          

Ala Leu Ala Gly Val Val Leu Phe Gly Met Phe Leu Val Val Ala Ile 
        35                  40                  45              

Phe Ala Pro Ala Ile Ala Pro Tyr Asn Pro Thr Ser Thr Ala Phe Gly 
    50                  55                  60                  

Met Leu Gln Pro Pro Ser His Ala His Trp Phe Gly Thr Thr Ser Leu 
65                  70                  75                  80  

Gly Gln Asp Val Phe Ser Gln Phe Ile Trp Gly Thr Arg Thr Thr Leu 
                85                  90                  95      

Ile Val Gly Val Gly Ala Gly Leu Leu Ser Thr Val Ile Ala Ile Leu 
            100                 105                 110         

Ile Gly Val Thr Ala Gly Tyr Val Gly Gly Val Val Asp Ser Ile Leu 
        115                 120                 125             

Asn Ala Leu Cys Asn Ile Phe Leu Val Met Pro Gly Leu Ala Leu Leu 
    130                 135                 140                 

Ile Ile Ile Glu Ser Tyr Ile His Asn Thr Thr Pro Tyr Met Asn Gly 
145                 150                 155                 160 

Leu Ile Ile Ala Leu Thr Gly Trp Ala Trp Gly Ala Arg Val Met Arg 
                165                 170                 175     

Ser Met Ala Met Thr Ile Ala Ser Arg Asp Tyr Ile Ala Ala Ala Arg 
            180                 185                 190         

Leu Ser Gly Met Ser Thr Phe Arg Ile Ile Leu Phe Glu Ile Val Pro 
        195                 200                 205             

Asn Met Thr Ser Val Ile Ala Ser Asn Val Met Tyr Ala Cys Leu Ala 
    210                 215                 220                 

Ala Val Leu Ala Glu Ser Gly Leu Ala Tyr Leu Gly Phe Glu Asn Val 
225                 230                 235                 240 

Ala Ser Thr Ser Trp Gly Thr Met Leu Tyr Trp Ala Thr Gln Asn Ser 
                245                 250                 255     

Ala Leu Met Ser Gly Ala Trp Trp Trp Phe Val Pro Pro Gly Leu Gly 
            260                 265                 270         

Ile Ala Leu Leu Gly Thr Ser Phe Ala Leu Met Asn Phe Gly Ile Asp 
        275                 280                 285             

Gln Val Thr Asn Pro Arg Leu Arg Thr Ser Arg Arg Arg Arg Gln Val 
    290                 295                 300                 

Glu Lys Leu Leu Arg Glu Leu Arg Ala Gln Asn Gly Glu Val Lys Ala 
305                 310                 315                 320 

Asp Gly Arg Asp Ala Arg Thr Gly Ala Ser Asp 
                325                 330     

<210>   553
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   553
Met Thr Val Ala Ala Ile Asp Val Val Asp Pro Arg Ala Lys Arg Ala 
                5                   10                  15      

Ser Arg Arg Arg Asn Ser Ala Leu Arg Gln Phe Phe Arg Asn Pro Lys 
            20                  25                  30          

Ala Leu Ala Gly Val Val Leu Phe Gly Met Phe Leu Val Val Ala Ile 
        35                  40                  45              

Phe Ala Pro Ala Ile Ala Pro Tyr Asn Pro Thr Ser Thr Ala Phe Gly 
    50                  55                  60                  

Met Leu Gln Pro Pro Ser His Ala His Trp Phe Gly Thr Thr Ser Leu 
65                  70                  75                  80  

Gly Gln Asp Val Phe Ser Gln Phe Ile Trp Gly Thr Arg Thr Thr Leu 
                85                  90                  95      

Ile Val Gly Val Gly Ala Gly Leu Leu Ser Thr Val Ile Ala Ile Leu 
            100                 105                 110         

Ile Gly Val Thr Ala Gly Tyr Val Gly Gly Val Val Asp Ser Ile Leu 
        115                 120                 125             

Asn Ala Leu Cys Asn Ile Phe Leu Val Met Pro Gly Leu Ala Leu Leu 
    130                 135                 140                 

Ile Ile Ile Glu Ser Tyr Val His Asn Thr Thr Pro Tyr Met Asn Gly 
145                 150                 155                 160 

Leu Ile Ile Ala Leu Thr Gly Trp Ala Trp Gly Ala Arg Val Met Arg 
                165                 170                 175     

Ser Met Ala Met Thr Ile Ala Ser Arg Asp Tyr Ile Ala Ala Ala Arg 
            180                 185                 190         

Leu Ser Gly Met Ser Thr Phe Arg Ile Ile Leu Phe Glu Ile Val Pro 
        195                 200                 205             

Asn Met Thr Ser Val Ile Ala Ser Asn Val Met Tyr Ala Cys Leu Ala 
    210                 215                 220                 

Ala Val Leu Ala Glu Ser Gly Leu Ala Tyr Leu Gly Phe Glu Asn Val 
225                 230                 235                 240 

Ala Ser Thr Ser Trp Gly Thr Met Leu Tyr Trp Ala Thr Gln Asn Ser 
                245                 250                 255     

Ala Leu Met Ser Gly Ala Trp Trp Trp Phe Val Pro Pro Gly Leu Gly 
            260                 265                 270         

Ile Ala Leu Ile Gly Thr Ser Phe Ala Leu Met Asn Phe Gly Ile Asp 
        275                 280                 285             

Gln Val Thr Asn Pro Arg Leu Arg Thr Ser Arg Arg Arg Arg Gln Val 
    290                 295                 300                 

Glu Lys Leu Leu Arg Glu Leu Arg Ala Gln Asn Gly Glu Val Lys Ala 
305                 310                 315                 320 

Asp Gly Arg Asp Ala Arg Thr Gly Ala Ser Asp 
                325                 330     

<210>   554
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   554
Met Thr Val Ala Ala Ile Asp Val Val Asp Pro Arg Ala Lys Arg Ala 
                5                   10                  15      

Ser Arg Arg Arg Asn Ser Ala Leu Lys Gln Phe Phe Arg Asn Pro Lys 
            20                  25                  30          

Ala Leu Ala Gly Val Val Leu Phe Gly Met Phe Leu Val Val Ala Ile 
        35                  40                  45              

Phe Ala Pro Ala Ile Ala Pro Tyr Asn Pro Thr Ser Thr Ala Phe Gly 
    50                  55                  60                  

Met Leu Gln Pro Pro Ser His Ala His Trp Phe Gly Thr Thr Ser Leu 
65                  70                  75                  80  

Gly Gln Asp Val Phe Ser Gln Phe Ile Trp Gly Thr Arg Thr Thr Leu 
                85                  90                  95      

Ile Val Gly Val Gly Ala Gly Leu Leu Ser Thr Val Ile Ala Ile Leu 
            100                 105                 110         

Ile Gly Val Thr Ala Gly Tyr Val Gly Gly Val Val Asp Ser Ile Leu 
        115                 120                 125             

Asn Ala Leu Cys Asn Ile Phe Leu Val Met Pro Gly Leu Ala Leu Leu 
    130                 135                 140                 

Ile Ile Ile Glu Ser Tyr Val His Asn Thr Thr Pro Tyr Met Asn Gly 
145                 150                 155                 160 

Leu Ile Ile Ala Leu Thr Gly Trp Ala Trp Gly Ala Arg Val Met Arg 
                165                 170                 175     

Ser Met Ala Met Thr Ile Ala Ser Arg Asp Tyr Ile Ala Ala Ala Arg 
            180                 185                 190         

Leu Ser Gly Met Ser Thr Phe Arg Ile Ile Leu Phe Glu Ile Val Pro 
        195                 200                 205             

Asn Met Thr Ser Val Ile Ala Ser Asn Val Met Tyr Ala Cys Leu Ala 
    210                 215                 220                 

Ala Val Leu Ala Glu Ser Gly Leu Ala Tyr Leu Gly Phe Glu Asn Val 
225                 230                 235                 240 

Ala Ser Thr Ser Trp Gly Thr Met Leu Tyr Trp Ala Thr Gln Asn Ser 
                245                 250                 255     

Ala Leu Met Ser Gly Ala Trp Trp Trp Phe Val Pro Pro Gly Leu Gly 
            260                 265                 270         

Ile Ala Leu Leu Gly Thr Ser Phe Ala Leu Met Asn Phe Gly Ile Asp 
        275                 280                 285             

Gln Val Thr Asn Pro Arg Leu Arg Thr Ser Arg Arg Arg Arg Gln Val 
    290                 295                 300                 

Glu Lys Leu Leu Arg Glu Leu Arg Ala Gln Asn Gly Glu Val Lys Ala 
305                 310                 315                 320 

Asp Gly Arg Asp Ala Arg Thr Gly Ala Ser Asp 
                325                 330     

<210>   555
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   555
Met Thr Val Ala Ala Ile Asp Val Val Asp Pro Arg Ala Lys Arg Ala 
                5                   10                  15      

Ser Arg Arg Arg Asn Ser Ala Leu Arg Gln Phe Phe Arg Asn Pro Lys 
            20                  25                  30          

Ala Leu Ala Gly Val Val Leu Phe Gly Met Phe Leu Val Val Ala Ile 
        35                  40                  45              

Phe Ala Pro Ala Ile Ala Pro Tyr Asn Pro Thr Ser Thr Ala Phe Gly 
    50                  55                  60                  

Met Leu Gln Pro Pro Ser His Ala His Trp Phe Gly Thr Thr Ser Leu 
65                  70                  75                  80  

Gly Gln Asp Val Phe Ser Gln Phe Ile Trp Gly Thr Arg Thr Thr Leu 
                85                  90                  95      

Ile Val Gly Val Gly Ala Gly Leu Leu Ser Thr Val Ile Ala Ile Leu 
            100                 105                 110         

Ile Gly Val Thr Ala Gly Tyr Val Gly Gly Val Val Asp Ser Ile Leu 
        115                 120                 125             

Asn Ala Leu Cys Asn Ile Phe Leu Val Met Pro Gly Leu Ala Leu Leu 
    130                 135                 140                 

Ile Ile Leu Glu Ser Tyr Val His Asn Thr Thr Pro Tyr Met Asn Gly 
145                 150                 155                 160 

Leu Ile Ile Ala Leu Thr Gly Trp Ala Trp Gly Ala Arg Val Met Arg 
                165                 170                 175     

Ser Met Ala Met Thr Ile Ala Ser Arg Asp Tyr Ile Ala Ala Ala Arg 
            180                 185                 190         

Leu Ser Gly Met Ser Thr Phe Arg Ile Ile Leu Phe Glu Ile Val Pro 
        195                 200                 205             

Asn Met Thr Ser Val Ile Ala Ser Asn Val Met Tyr Ala Cys Leu Ala 
    210                 215                 220                 

Ala Val Leu Ala Glu Ser Gly Leu Ala Tyr Leu Gly Phe Glu Asn Val 
225                 230                 235                 240 

Ala Ser Thr Ser Trp Gly Thr Met Leu Tyr Trp Ala Thr Gln Asn Ser 
                245                 250                 255     

Ala Leu Met Ser Gly Ala Trp Trp Trp Phe Val Pro Pro Gly Leu Gly 
            260                 265                 270         

Ile Ala Leu Leu Gly Thr Ser Phe Ala Leu Met Asn Phe Gly Ile Asp 
        275                 280                 285             

Gln Val Thr Asn Pro Arg Leu Arg Thr Ser Arg Arg Arg Arg Gln Val 
    290                 295                 300                 

Glu Lys Leu Leu Arg Glu Leu Arg Ala Gln Asn Gly Glu Val Lys Ala 
305                 310                 315                 320 

Asp Gly Arg Asp Ala Arg Thr Gly Ala Ser Asp 
                325                 330     

<210>   556
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 545

<400>   556
Met Thr Val Ala Ala Ile Asp Val Val Asp Pro Arg Ala Lys Arg Ala 
                5                   10                  15      

Ser Arg Arg Arg Gln Ser Ala Leu Arg Gln Phe Phe Arg Asn Pro Lys 
            20                  25                  30          

Ala Leu Ala Gly Val Val Leu Phe Gly Met Phe Leu Val Val Ala Ile 
        35                  40                  45              

Phe Ala Pro Ala Ile Ala Pro Tyr Asn Pro Thr Ser Thr Ala Phe Gly 
    50                  55                  60                  

Met Leu Gln Pro Pro Ser His Ala His Trp Phe Gly Thr Thr Ser Leu 
65                  70                  75                  80  

Gly Gln Asp Val Phe Ser Gln Phe Ile Trp Gly Thr Arg Thr Thr Leu 
                85                  90                  95      

Ile Val Gly Val Gly Ala Gly Leu Leu Ser Thr Val Ile Ala Ile Leu 
            100                 105                 110         

Ile Gly Val Thr Ala Gly Tyr Val Gly Gly Val Val Asp Ser Ile Leu 
        115                 120                 125             

Asn Ala Leu Cys Asn Ile Phe Leu Val Met Pro Gly Leu Ala Leu Leu 
    130                 135                 140                 

Ile Ile Ile Glu Ser Tyr Val His Asn Thr Thr Pro Tyr Met Asn Gly 
145                 150                 155                 160 

Leu Ile Ile Ala Leu Thr Gly Trp Ala Trp Gly Ala Arg Val Met Arg 
                165                 170                 175     

Ser Met Ala Met Thr Ile Ala Ser Arg Asp Tyr Ile Ala Ala Ala Arg 
            180                 185                 190         

Leu Ser Gly Met Ser Thr Phe Arg Ile Ile Leu Phe Glu Ile Val Pro 
        195                 200                 205             

Asn Met Thr Ser Val Ile Ala Ser Asn Val Met Tyr Ala Cys Leu Ala 
    210                 215                 220                 

Ala Val Leu Ala Glu Ser Gly Leu Ala Tyr Leu Gly Phe Glu Asn Val 
225                 230                 235                 240 

Ala Ser Thr Ser Trp Gly Thr Met Leu Tyr Trp Ala Thr Gln Asn Ser 
                245                 250                 255     

Ala Leu Met Ser Gly Ala Trp Trp Trp Phe Val Pro Pro Gly Leu Gly 
            260                 265                 270         

Ile Ala Leu Leu Gly Thr Ser Phe Ala Leu Met Asn Phe Gly Ile Asp 
        275                 280                 285             

Gln Val Thr Asn Pro Arg Leu Arg Thr Ser Arg Arg Arg Arg Gln Val 
    290                 295                 300                 

Glu Lys Leu Leu Arg Glu Leu Arg Ala Gln Asn Gly Glu Val Lys Ala 
305                 310                 315                 320 

Asp Gly Arg Asp Ala Arg Thr Gly Ala Ser Asp 
                325                 330     

<210>   557
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   557
atgacagtcg cagccatcga tgtggtggat ccgcgcgcga agcgggcgag caggcgcaga       60

aactcggcgt tgcgccagtt ctttcgaaat ccgaaggcgc tcgcgggcgt cgtcctgttt      120

ggcatgtttc tggtggtggc catttttgcg cctgccatcg cgccctacaa tccaacttcc      180

acggcgtttg gcatgctgca acctccgtcg cacgcgcact ggttcggcac gacgagcctt      240

ggccaggacg tgttttcaca gttcatctgg ggcacgcgga ccacgctcat cgtgggcgtc      300

ggagcggggc ttttgagcac cgtgatcgcc atcctgatcg gcgtgacggc agggtatgtc      360

ggcggcgtgg tcgattcaat cctaaacgcg ctctgtaaca ttttcctcgt catgccggga      420

ttggcgctgc tcatcatcat cgaatcgtac attcacaaca cgacgccgta tatgaacggt      480

ctgatcatcg cgctgacggg ctgggcgtgg ggcgcgcgcg tgatgcggtc catggccatg      540

accattgcga gccgggatta catcgcggcg gcgcgcctgt cggggatgtc gacgttccgc      600

atcatcctgt tcgagatcgt gccgaacatg acgagcgtca ttgcctccaa cgtgatgtac      660

gcctgtctgg cggcggtgct cgcggagtcg ggcctcgcgt atctcgggtt cgaaaatgtg      720

gcctcgacga gctggggcac gatgctgtac tgggcgacgc agaacagcgc gctgatgagc      780

ggggcgtggt ggtggttcgt gccgccgggg ctcggcatcg cgcttctcgg cacgagcttt      840

gccctgatga acttcggcat cgaccaggtc accaacccgc gtctgcgcac gtcgcgcagg      900

cgtcgacagg tcgagaaact gctgcgcgag cttcgggcgc agaacggtga ggtgaaggcg      960

gatggcagag acgcgagaac cggtgcttca gattga                                996


<210>   558
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   558
atgacagtcg cagccatcga tgtggtggat ccgcgcgcga agcgggcgag caggcgcaga       60

aactcggcgt tgcgccagtt ctttcgaaat ccgaaggcgc tcgcgggcgt cgtcctgttt      120

ggcatgtttc tggtggtggc catttttgcg cctgccatcg cgccctacaa tccaacttcc      180

acggcgtttg gcatgctgca acctccgtcg cacgcgcact ggttcggcac gacgagcctt      240

ggccaggacg tgttttcaca gttcatctgg ggcacgcgga ccacgctcat cgtgggcgtc      300

ggagcggggc ttttgagcac cgtgatcgcc atcctgatcg gcgtgacggc agggtatgtc      360

ggcggcgtgg tcgattcaat cctaaacgcg ctctgtaaca ttttcctcgt catgccggga      420

ttggcgctgc tcatcatcat cgaatcgtac gtgcacaaca cgacgccgta tatgaacggt      480

ctgatcatcg cgctgacggg ctgggcgtgg ggcgcgcgcg tgatgcggtc catggccatg      540

accattgcga gccgggatta catcgcggcg gcgcgcctgt cggggatgtc gacgttccgc      600

atcatcctgt tcgagatcgt gccgaacatg acgagcgtca ttgcctccaa cgtgatgtac      660

gcctgtctgg cggcggtgct cgcggagtcg ggcctcgcgt atctcgggtt cgaaaatgtg      720

gcctcgacga gctggggcac gatgctgtac tgggcgacgc agaacagcgc gctgatgagc      780

ggggcgtggt ggtggttcgt gccgccgggg ctcggcatcg cgcttattgg cacgagcttt      840

gccctgatga acttcggcat cgaccaggtc accaacccgc gtctgcgcac gtcgcgcagg      900

cgtcgacagg tcgagaaact gctgcgcgag cttcgggcgc agaacggtga ggtgaaggcg      960

gatggcagag acgcgagaac cggtgcttca gattga                                996


<210>   559
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   559
atgacagtcg cagccatcga tgtggtggat ccgcgcgcga agcgggcgag caggcgcaga       60

aactcggcgt tgaaacagtt ctttcgaaat ccgaaggcgc tcgcgggcgt cgtcctgttt      120

ggcatgtttc tggtggtggc catttttgcg cctgccatcg cgccctacaa tccaacttcc      180

acggcgtttg gcatgctgca acctccgtcg cacgcgcact ggttcggcac gacgagcctt      240

ggccaggacg tgttttcaca gttcatctgg ggcacgcgga ccacgctcat cgtgggcgtc      300

ggagcggggc ttttgagcac cgtgatcgcc atcctgatcg gcgtgacggc agggtatgtc      360

ggcggcgtgg tcgattcaat cctaaacgcg ctctgtaaca ttttcctcgt catgccggga      420

ttggcgctgc tcatcatcat cgaatcgtac gtgcacaaca cgacgccgta tatgaacggt      480

ctgatcatcg cgctgacggg ctgggcgtgg ggcgcgcgcg tgatgcggtc catggccatg      540

accattgcga gccgggatta catcgcggcg gcgcgcctgt cggggatgtc gacgttccgc      600

atcatcctgt tcgagatcgt gccgaacatg acgagcgtca ttgcctccaa cgtgatgtac      660

gcctgtctgg cggcggtgct cgcggagtcg ggcctcgcgt atctcgggtt cgaaaatgtg      720

gcctcgacga gctggggcac gatgctgtac tgggcgacgc agaacagcgc gctgatgagc      780

ggggcgtggt ggtggttcgt gccgccgggg ctcggcatcg cgcttctcgg cacgagcttt      840

gccctgatga acttcggcat cgaccaggtc accaacccgc gtctgcgcac gtcgcgcagg      900

cgtcgacagg tcgagaaact gctgcgcgag cttcgggcgc agaacggtga ggtgaaggcg      960

gatggcagag acgcgagaac cggtgcttca gattga                                996


<210>   560
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   560
atgacagtcg cagccatcga tgtggtggat ccgcgcgcga agcgggcgag caggcgcaga       60

aactcggcgt tgcgccagtt ctttcgaaat ccgaaggcgc tcgcgggcgt cgtcctgttt      120

ggcatgtttc tggtggtggc catttttgcg cctgccatcg cgccctacaa tccaacttcc      180

acggcgtttg gcatgctgca acctccgtcg cacgcgcact ggttcggcac gacgagcctt      240

ggccaggacg tgttttcaca gttcatctgg ggcacgcgga ccacgctcat cgtgggcgtc      300

ggagcggggc ttttgagcac cgtgatcgcc atcctgatcg gcgtgacggc agggtatgtc      360

ggcggcgtgg tcgattcaat cctaaacgcg ctctgtaaca ttttcctcgt catgccggga      420

ttggcgctgc tcatcatctt agaatcgtac gtgcacaaca cgacgccgta tatgaacggt      480

ctgatcatcg cgctgacggg ctgggcgtgg ggcgcgcgcg tgatgcggtc catggccatg      540

accattgcga gccgggatta catcgcggcg gcgcgcctgt cggggatgtc gacgttccgc      600

atcatcctgt tcgagatcgt gccgaacatg acgagcgtca ttgcctccaa cgtgatgtac      660

gcctgtctgg cggcggtgct cgcggagtcg ggcctcgcgt atctcgggtt cgaaaatgtg      720

gcctcgacga gctggggcac gatgctgtac tgggcgacgc agaacagcgc gctgatgagc      780

ggggcgtggt ggtggttcgt gccgccgggg ctcggcatcg cgcttctcgg cacgagcttt      840

gccctgatga acttcggcat cgaccaggtc accaacccgc gtctgcgcac gtcgcgcagg      900

cgtcgacagg tcgagaaact gctgcgcgag cttcgggcgc agaacggtga ggtgaaggcg      960

gatggcagag acgcgagaac cggtgcttca gattga                                996


<210>   561
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 546

<400>   561
atgacagtcg cagccatcga tgtggtggat ccgcgcgcga agcgggcgag caggcgcaga       60

caatcggcgt tgcgccagtt ctttcgaaat ccgaaggcgc tcgcgggcgt cgtcctgttt      120

ggcatgtttc tggtggtggc catttttgcg cctgccatcg cgccctacaa tccaacttcc      180

acggcgtttg gcatgctgca acctccgtcg cacgcgcact ggttcggcac gacgagcctt      240

ggccaggacg tgttttcaca gttcatctgg ggcacgcgga ccacgctcat cgtgggcgtc      300

ggagcggggc ttttgagcac cgtgatcgcc atcctgatcg gcgtgacggc agggtatgtc      360

ggcggcgtgg tcgattcaat cctaaacgcg ctctgtaaca ttttcctcgt catgccggga      420

ttggcgctgc tcatcatcat cgaatcgtac gtgcacaaca cgacgccgta tatgaacggt      480

ctgatcatcg cgctgacggg ctgggcgtgg ggcgcgcgcg tgatgcggtc catggccatg      540

accattgcga gccgggatta catcgcggcg gcgcgcctgt cggggatgtc gacgttccgc      600

atcatcctgt tcgagatcgt gccgaacatg acgagcgtca ttgcctccaa cgtgatgtac      660

gcctgtctgg cggcggtgct cgcggagtcg ggcctcgcgt atctcgggtt cgaaaatgtg      720

gcctcgacga gctggggcac gatgctgtac tgggcgacgc agaacagcgc gctgatgagc      780

ggggcgtggt ggtggttcgt gccgccgggg ctcggcatcg cgcttctcgg cacgagcttt      840

gccctgatga acttcggcat cgaccaggtc accaacccgc gtctgcgcac gtcgcgcagg      900

cgtcgacagg tcgagaaact gctgcgcgag cttcgggcgc agaacggtga ggtgaaggcg      960

gatggcagag acgcgagaac cggtgcttca gattga                                996


<210>   562
<211>   331
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   562
Met Ala Glu Thr Arg Glu Pro Val Leu Gln Ile Glu Asp Leu Ser Val 
                5                   10                  15      

Ala Tyr Val Thr Asn Thr Gly Leu Val His Ala Val Ser Asp Val Asn 
            20                  25                  30          

Leu Thr Val His Arg Gly Glu Ile Val Gly Leu Val Gly Glu Ser Gly 
        35                  40                  45              

Ser Gly Lys Ser Thr Met Ala Tyr Thr Ile Met Arg Leu Leu Arg Gly 
    50                  55                  60                  

Asp Ala Val Val Thr Lys Gly Arg Val Arg Val Leu Gly Gln Asp Val 
65                  70                  75                  80  

Tyr Ala Leu Ser Glu Lys Glu Leu Arg Ala Phe Arg Trp Ser Lys Met 
                85                  90                  95      

Ser Met Val Phe Gln Ser Ala Met Ser Ala Leu Asn Pro Val Met Thr 
            100                 105                 110         

Val Glu Thr Gln Ile Val Asp Thr Ile Leu Ala His Arg Pro Asp Leu 
        115                 120                 125             

Ser Arg Gln Ala Ala Arg Glu Arg Ala Lys Glu Leu Leu Asp Leu Val 
    130                 135                 140                 

Arg Ile Asp Arg Lys His Leu Gln Ser Tyr Pro His Glu Leu Ser Gly 
145                 150                 155                 160 

Gly Met Arg Gln Arg Val Val Ile Ala Ile Ala Ile Ala Leu Asn Pro 
                165                 170                 175     

Ala Leu Val Ile Met Asp Glu Pro Thr Thr Ala Leu Asp Val Val Val 
            180                 185                 190         

Gln Arg Ser Ile Leu Asp Glu Ile Arg Arg Ile Gln Glu Gln Val Gly 
        195                 200                 205             

Phe Ala Ile Leu Phe Val Ser His Asp Phe Ser Leu Val Ala Glu Leu 
    210                 215                 220                 

Ala Ser Arg Val Ala Ile Met Tyr Ala Gly Arg Ile Val Glu Leu Thr 
225                 230                 235                 240 

Pro Ser His Leu Leu Asn Leu Ser Glu Arg His His Pro Tyr Thr Glu 
                245                 250                 255     

Gly Leu Leu Lys Ala Ile Pro Gln Leu Thr Ala Asp Glu Val Thr Ile 
            260                 265                 270         

Gln Gly Ile Gly Gly Tyr Pro Pro Asp Leu Gln Asp Leu Pro Pro Gly 
        275                 280                 285             

Cys Ala Phe His Pro Arg Cys Pro Tyr Ala Met Asp Val Cys Arg Arg 
    290                 295                 300                 

Val Arg Pro Ala Gln Val Arg Ala Gly Glu Lys Val Leu Glu Cys His 
305                 310                 315                 320 

Leu Phe Asn Glu Ala Glu Val Lys Ala His Val 
                325                 330     

<210>   563
<211>   996
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   563
atggcagaga cgcgagaacc ggtgcttcag attgaggacc tgtccgtcgc ctacgtgacg       60

aacacggggc tcgtgcacgc ggtgagcgac gtgaacctga ccgtccatcg gggcgagatc      120

gtgggactgg ttggggagtc gggatcgggc aagtcgacga tggcgtacac catcatgcgg      180

ctgttgcgcg gcgacgcggt ggtcaccaag ggccgcgtgc gggtgttggg ccaggatgtg      240

tacgcgctgt ccgaaaagga actgagggcg tttcgctgga gcaagatgtc catggtgttc      300

cagagcgcga tgagcgccct gaacccggtg atgacggtgg agacgcagat cgtcgacacc      360

atcttggcac accggccgga tctgtcgcgg caggcggcgc gggagcgggc gaaggagttg      420

ctcgatctcg tccgaatcga ccggaaacac ctgcagagct atccgcacga gctttccggc      480

ggcatgcgcc agcgggtcgt gatcgccatc gcgattgcgc tcaatcccgc gctcgtcatc      540

atggatgagc cgacgaccgc gcttgacgtt gtggtgcagc ggtccattct ggacgaaatc      600

cggcgcatcc aggagcaggt gggcttcgcc atcttgtttg tcagccacga cttcagcctg      660

gtggcggagc tcgcgtcccg cgtcgccatc atgtacgcgg gccgcatcgt cgaactcacg      720

ccgagccacc tgttgaacct gtccgagcgg caccacccgt acacggaggg gctcctgaag      780

gccattcctc agctgaccgc ggacgaggtg accatccagg ggattggcgg atacccaccg      840

gatctgcagg acctgccgcc cggctgcgcg tttcatccgc gctgcccgta cgccatggac      900

gtctgcaggc gcgtgcgccc ggcgcaggtg cgggcgggcg agaaggtgct ggagtgccac      960

ctgttcaacg aggcggaggt gaaggcccat gtctga                                996


<210>   564
<211>   315
<212>   PRT
<213>   Sorangium cellulosum 'So ce 56'

<400>   564
Pro Leu Leu Ser Val Gln Asp Leu Arg Val Glu Phe Ile Thr Pro Thr 
                5                   10                  15      

Gly Pro Val Cys Ala Val Asp Asn Val Ser Phe Asp Ile Ala Pro Gly 
            20                  25                  30          

Glu Val Leu Gly Leu Ala Gly Glu Ser Gly Ser Gly Lys Ser Thr Val 
        35                  40                  45              

Ala Met Ala Ile Met Arg Leu Leu Arg Pro Pro Ala Val Ile Thr Gly 
    50                  55                  60                  

Gly His Val Tyr Phe Ala Gly Gln Asp Val Leu Ala Met Asn Glu Glu 
65                  70                  75                  80  

Gln Leu Arg Ala Phe Arg Trp Arg Lys Met Ala Leu Val Phe Gln Ser 
                85                  90                  95      

Ala Met Thr Ala Leu Asn Pro Val Leu Thr Ile Gly Glu Gln Ile Ser 
            100                 105                 110         

Asp Pro Ile Ile Ala His Asp Gly Val Thr Pro Ala Gln Ala Met Glu 
        115                 120                 125             

Arg Ala Ala Ala Leu Leu Lys Leu Val Asn Ile Asp Ser Ser Arg Leu 
    130                 135                 140                 

Asn Ser Tyr Pro His Gln Leu Ser Gly Gly Met Arg Gln Arg Val Val 
145                 150                 155                 160 

Ile Ala Ile Ala Met Ala Leu Lys Pro Pro Phe Leu Ile Met Asp Glu 
                165                 170                 175     

Pro Thr Thr Ala Leu Asp Val Val Val Gln Arg Glu Ile Leu Gln Gln 
            180                 185                 190         

Ile Ala Glu Leu Lys Glu Arg Leu Gly Phe Ser Ile Leu Phe Ile Thr 
        195                 200                 205             

His Asp Leu Ser Leu Ile Ala Glu Phe Ser Thr Arg Ile Ala Ile Leu 
    210                 215                 220                 

Tyr Ala Gly Lys Leu Ala Glu Thr Ala Arg Ala Lys Asp Leu Phe Ser 
225                 230                 235                 240 

Asp Pro Lys His Pro Tyr Thr Gln Gly Leu Leu Gly Ser Phe Pro Ser 
                245                 250                 255     

Val Arg Gly Pro Arg Arg Lys Leu Gln Gly Ile Pro Gly Ser Pro Pro 
            260                 265                 270         

Asp Met Arg Asn Pro Pro Ala Gly Cys Arg Phe His Pro Arg Cys Pro 
        275                 280                 285             

Gln Ala Phe Ala Thr Cys Gln Asn Glu Leu Pro Val Leu Arg Glu Ile 
    290                 295                 300                 

Ala Pro Glu His Arg Gly Ala Cys His Leu Tyr 
305                 310                 315 

<210>   565
<211>   317
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   565
Glu Pro Leu Leu Asp Val Gln Asn Leu Ser Val Glu Tyr Gln Thr Leu 
                5                   10                  15      

Arg Gly Pro Val Gln Ala Val Ser Asn Val Ser Phe Ser Ile Gly Gln 
            20                  25                  30          

Gly Glu Val Phe Gly Leu Ala Gly Glu Ser Gly Ser Gly Lys Ser Thr 
        35                  40                  45              

Ile Ala His Ala Ile Met Arg Ile Leu His Ser Pro Ala Val Ile Thr 
    50                  55                  60                  

Gly Gly Asn Val Leu Phe Asp Gly Asp Asp Val Leu Glu Met Asp Met 
65                  70                  75                  80  

Glu Gly Leu Glu Ala Phe Arg Trp Arg Asp Ile Ser Met Val Phe Gln 
                85                  90                  95      

Ser Ala Met Asn Ala Leu Asn Pro Val Leu Thr Val Gly Glu Gln Ile 
            100                 105                 110         

Ile Asp Val Ile Gln Arg His Gln Pro Lys Thr Thr Lys Gln Gln Ala 
        115                 120                 125             

Lys Asp Arg Ala Ala Glu Leu Leu Asp Ile Val Gly Ile Asp Gly Lys 
    130                 135                 140                 

Arg Val Asp Asp Tyr Pro His Gln Leu Ser Gly Gly Met Arg Gln Arg 
145                 150                 155                 160 

Val Val Ile Ala Val Ala Leu Ala Leu Lys Pro Gln Leu Met Ile Met 
                165                 170                 175     

Asp Glu Pro Thr Thr Ala Leu Asp Val Val Val Gln Lys Asp Ile Met 
            180                 185                 190         

Gln Gln Ile Glu Tyr Leu Lys Lys Glu Leu Asp Phe Ser Ile Leu Phe 
        195                 200                 205             

Ile Thr His Asp Leu Ser Leu Met Val Glu Phe Ser Asp Arg Ile Gly 
    210                 215                 220                 

Val Met Tyr Ala Gly Glu Ile Val Glu Met Thr Ala Ala His Glu Leu 
225                 230                 235                 240 

Phe Asn Lys Pro Met His Pro Tyr Thr Gln Gly Leu Met Ala Ser Phe 
                245                 250                 255     

Pro Ala Leu Val Gly Pro Lys Glu Thr Leu Thr Gly Ile Pro Gly Ser 
            260                 265                 270         

Pro Pro Asn Met Leu Glu Pro Pro Ser Gly Cys Arg Phe His Pro Arg 
        275                 280                 285             

Cys Pro Lys Ala Ile Ala Gln Cys Ser Leu Gln Gln Pro Thr Leu Arg 
    290                 295                 300                 

Glu Val Glu Pro Gly His Phe Val Ala Cys His Leu Tyr 
305                 310                 315         

<210>   566
<211>   324
<212>   PRT
<213>   Vibrio sp. Ex25

<400>   566
Pro Leu Ile Ser Ile Arg Asn Leu Cys Val Asp Tyr Ile Thr Asp Ala 
                5                   10                  15      

Gly Asp Val Arg Ala Cys Asn Asn Val Ser Phe Asp Ile Ala Pro Gly 
            20                  25                  30          

Glu Val Phe Gly Leu Ala Gly Glu Ser Gly Cys Gly Lys Ser Thr Val 
        35                  40                  45              

Ala Phe Ser Leu Met Arg Leu His Lys Pro Pro Ala Phe Ile Thr Gly 
    50                  55                  60                  

Gly Glu Val Ile Phe Asn Gly Glu Asp Ile Ile Lys Tyr Ser Asp Glu 
65                  70                  75                  80  

Arg Met Gln Ser Phe Arg Trp Ser Glu Met Ser Met Val Phe Gln Ser 
                85                  90                  95      

Ala Met Asn Ala Leu Asn Pro Val Leu Thr Met Glu Glu Gln Phe Cys 
            100                 105                 110         

Asp Val Ile Met Arg His Thr Asn Met Thr Arg Glu Gln Ala Lys Lys 
        115                 120                 125             

Arg Ala Glu Gly Leu Leu Glu Ile Val Asp Ile His Pro Ser Arg Leu 
    130                 135                 140                 

Asn Asp Tyr Pro His Gln Phe Ser Gly Gly Met Arg Gln Arg Leu Val 
145                 150                 155                 160 

Ile Ala Ile Ala Leu Ala Leu Asn Pro Lys Met Ile Ile Met Asp Glu 
                165                 170                 175     

Pro Thr Thr Ala Leu Asp Val Val Val Gln Arg Glu Ile Leu Gln Lys 
            180                 185                 190         

Ile Tyr Ala Leu Lys Glu Glu Phe Gly Phe Ser Ile Leu Phe Ile Thr 
        195                 200                 205             

His Asp Leu Ser Leu Met Val Glu Phe Ser Asp Arg Ile Gly Ile Met 
    210                 215                 220                 

Tyr Ser Gly Glu Leu Ile Glu Val Ala Pro Ser Lys Gln Ile Leu Glu 
225                 230                 235                 240 

Ser Pro Tyr His Pro Tyr Thr Lys Gly Leu Gly Ser Ser Phe Pro Pro 
                245                 250                 255     

Leu Thr Gly Pro Lys Thr Lys Leu Thr Gly Ile Pro Gly Asn Pro Leu 
            260                 265                 270         

Asn Leu Leu Glu Ile Pro Gln Gly Cys Arg Phe Gln Ala Arg Cys Asp 
        275                 280                 285             

Arg Val His Glu Ala Cys Thr Arg Val Pro Thr Gln Leu Arg Gln Ile 
    290                 295                 300                 

Glu Pro Gly Arg Phe Ser Asn Cys His Leu Tyr Gly Asp Thr Ile Ala 
305                 310                 315                 320 

Gln Ala Lys Val 
                

<210>   567
<211>   324
<212>   PRT
<213>   Vibrio parahaemolyticus RIMD 2210633

<400>   567
Pro Leu Ile Ser Ile Arg Asn Leu Cys Val Asp Tyr Ile Thr Asp Ala 
                5                   10                  15      

Gly Asp Val Arg Ala Cys Asn Asn Val Ser Phe Asp Ile Ala Pro Gly 
            20                  25                  30          

Glu Val Phe Gly Leu Ala Gly Glu Ser Gly Cys Gly Lys Ser Thr Val 
        35                  40                  45              

Ala Phe Ser Leu Met Arg Leu His Lys Pro Pro Ala Phe Ile Thr Gly 
    50                  55                  60                  

Gly Glu Val Ile Phe Asn Gly Glu Asp Ile Leu Gln Tyr Ser Asp Gln 
65                  70                  75                  80  

Arg Met Gln Ser Phe Arg Trp Ser Glu Met Ser Met Val Phe Gln Ser 
                85                  90                  95      

Ala Met Asn Ala Leu Asn Pro Val Leu Thr Met Glu Glu Gln Phe Cys 
            100                 105                 110         

Asp Val Ile Met Arg His Thr Gly Leu Thr Arg Ala Gln Ala Arg Val 
        115                 120                 125             

Arg Ala Glu Gly Leu Leu Glu Ile Val Asp Ile His Pro Ser Arg Leu 
    130                 135                 140                 

Ser Asp Tyr Pro His Gln Phe Ser Gly Gly Met Arg Gln Arg Leu Val 
145                 150                 155                 160 

Ile Ala Ile Ala Leu Ala Leu Asn Pro Lys Met Ile Ile Met Asp Glu 
                165                 170                 175     

Pro Thr Thr Ala Leu Asp Val Val Val Gln Arg Glu Ile Leu Gln Lys 
            180                 185                 190         

Ile Tyr Ala Leu Lys Glu Glu Phe Gly Phe Ser Ile Leu Phe Ile Thr 
        195                 200                 205             

His Asp Leu Ser Leu Met Val Glu Phe Ser Asp Arg Ile Gly Ile Met 
    210                 215                 220                 

Tyr Ser Gly Glu Leu Ile Glu Val Ala Pro Ser Lys Gln Ile Leu Glu 
225                 230                 235                 240 

Ser Pro Tyr His Pro Tyr Thr Lys Gly Leu Gly Ser Ser Phe Pro Pro 
                245                 250                 255     

Leu Thr Gly Pro Lys Thr Lys Leu Thr Gly Ile Pro Gly Asn Pro Leu 
            260                 265                 270         

Asn Leu Leu Glu Ile Pro Gln Gly Cys Arg Phe Gln Ala Arg Cys Asp 
        275                 280                 285             

Arg Val His Glu Ala Cys Thr Arg Val Pro Thr Gln Leu Arg Gln Ile 
    290                 295                 300                 

Glu Pro Gly Arg Tyr Ser Asn Cys His Leu Tyr Gly Asp Thr Ile Ala 
305                 310                 315                 320 

Gln Ala Lys Val 
                

<210>   568
<211>   324
<212>   PRT
<213>   Vibrio alginolyticus 12G01

<400>   568
Pro Leu Ile Ser Ile Arg Asn Leu Cys Val Asp Tyr Ile Thr Asp Ala 
                5                   10                  15      

Gly Asp Val Arg Ala Cys Asn Asn Val Ser Phe Asp Ile Ala Pro Gly 
            20                  25                  30          

Glu Val Phe Gly Leu Ala Gly Glu Ser Gly Cys Gly Lys Ser Thr Val 
        35                  40                  45              

Ala Phe Ser Leu Met Arg Leu His Lys Pro Pro Ala Phe Ile Thr Gly 
    50                  55                  60                  

Gly Glu Val Ile Phe Asn Gly Glu Asp Ile Leu Gln Tyr Ser Asp Asp 
65                  70                  75                  80  

Arg Met Gln Ala Phe Arg Trp Ser Glu Met Ser Met Val Phe Gln Ser 
                85                  90                  95      

Ala Met Asn Ala Leu Asn Pro Val Leu Thr Met Glu Glu Gln Phe Cys 
            100                 105                 110         

Asp Val Ile Met Arg His Thr Asn Met Thr Arg Ala Gln Ala Lys Thr 
        115                 120                 125             

Arg Ala Glu Gly Leu Leu Glu Ile Val Asp Ile His Pro Ser Arg Leu 
    130                 135                 140                 

Ser Asp Tyr Pro His Gln Phe Ser Gly Gly Met Arg Gln Arg Leu Val 
145                 150                 155                 160 

Ile Ala Ile Ala Leu Ala Leu Asn Pro Lys Met Ile Ile Met Asp Glu 
                165                 170                 175     

Pro Thr Thr Ala Leu Asp Val Val Val Gln Arg Glu Ile Leu Gln Lys 
            180                 185                 190         

Ile Tyr Ala Leu Lys Glu Glu Phe Gly Phe Ser Ile Leu Phe Ile Thr 
        195                 200                 205             

His Asp Leu Ser Leu Met Val Glu Phe Ser Asp Arg Ile Gly Ile Met 
    210                 215                 220                 

Tyr Ser Gly Glu Leu Ile Glu Val Ala Pro Ser Lys Gln Ile Leu Glu 
225                 230                 235                 240 

Ser Pro Tyr His Pro Tyr Thr Lys Gly Leu Gly Ser Ser Phe Pro Pro 
                245                 250                 255     

Leu Thr Gly Pro Lys Thr Lys Leu Thr Gly Ile Pro Gly Asn Pro Leu 
            260                 265                 270         

Asn Leu Leu Glu Val Pro Arg Gly Cys Arg Phe Gln Ala Arg Cys Asp 
        275                 280                 285             

Arg Val His Glu Ala Cys Thr Arg Val Pro Thr Gln Leu Arg Gln Ile 
    290                 295                 300                 

Glu Pro Gly Arg Leu Ser Asn Cys His Leu Tyr Gly Asp Thr Ile Ala 
305                 310                 315                 320 

Gln Ala Lys Val 
                

<210>   569
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   569
Met Ala Glu Thr Arg Glu Pro Val Leu Gln Ile Glu Asp Leu Ser Val 
                5                   10                  15      

Ala Tyr Val Thr Asn Thr Gly Leu Val His Ala Val Ser Asp Val Asn 
            20                  25                  30          

Leu Thr Val His Arg Gly Glu Ile Val Gly Leu Val Gly Glu Ser Gly 
        35                  40                  45              

Ser Gly Lys Ser Thr Met Ala Tyr Thr Ile Met Arg Leu Leu Arg Gly 
    50                  55                  60                  

Asp Ala Val Val Thr Lys Gly Arg Val Arg Val Leu Gly Gln Asp Val 
65                  70                  75                  80  

Tyr Ala Leu Ser Glu Lys Glu Leu Arg Ala Phe Arg Trp Ser Lys Met 
                85                  90                  95      

Ser Met Val Phe Gln Ser Ala Met Ser Ala Leu Asn Pro Val Met Thr 
            100                 105                 110         

Val Glu Thr Gln Ile Val Asp Thr Ile Leu Ala His Arg Pro Asp Leu 
        115                 120                 125             

Ser Arg Gln Ala Ala Arg Glu Arg Ala Lys Glu Leu Leu Asp Leu Val 
    130                 135                 140                 

Arg Ile Asp Arg Lys His Leu Gln Ser Tyr Pro His Glu Leu Ser Gly 
145                 150                 155                 160 

Gly Met Arg Gln Arg Ile Val Ile Ala Ile Ala Ile Ala Leu Asn Pro 
                165                 170                 175     

Ala Leu Val Ile Met Asp Glu Pro Thr Thr Ala Leu Asp Val Val Val 
            180                 185                 190         

Gln Arg Ser Ile Leu Asp Glu Ile Arg Arg Ile Gln Glu Gln Val Gly 
        195                 200                 205             

Phe Ala Ile Leu Phe Val Ser His Asp Phe Ser Leu Val Ala Glu Leu 
    210                 215                 220                 

Ala Ser Arg Val Ala Ile Met Tyr Ala Gly Arg Ile Val Glu Leu Thr 
225                 230                 235                 240 

Pro Ser His Leu Leu Asn Leu Ser Glu Arg His His Pro Tyr Thr Glu 
                245                 250                 255     

Gly Leu Leu Lys Ala Ile Pro Gln Leu Thr Ala Asp Glu Val Thr Ile 
            260                 265                 270         

Gln Gly Ile Gly Gly Tyr Pro Pro Asp Leu Gln Asp Leu Pro Pro Gly 
        275                 280                 285             

Cys Ala Phe His Pro Arg Cys Pro Tyr Ala Met Asp Val Cys Arg Arg 
    290                 295                 300                 

Val Arg Pro Ala Gln Val Arg Ala Gly Glu Lys Val Leu Glu Cys His 
305                 310                 315                 320 

Leu Phe Asn Glu Ala Glu Val Lys Ala His Val 
                325                 330     

<210>   570
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   570
Met Ala Glu Thr Arg Glu Pro Val Leu Gln Ile Glu Asp Leu Ser Val 
                5                   10                  15      

Ala Tyr Val Thr Asn Thr Gly Leu Val His Ala Val Ser Asp Val Asn 
            20                  25                  30          

Leu Thr Val His Arg Gly Glu Leu Val Gly Leu Val Gly Glu Ser Gly 
        35                  40                  45              

Ser Gly Lys Ser Thr Met Ala Tyr Thr Ile Met Arg Leu Leu Arg Gly 
    50                  55                  60                  

Asp Ala Val Val Thr Lys Gly Arg Val Arg Val Leu Gly Gln Asp Val 
65                  70                  75                  80  

Tyr Ala Leu Ser Glu Lys Glu Leu Arg Ala Phe Arg Trp Ser Lys Met 
                85                  90                  95      

Ser Met Val Phe Gln Ser Ala Met Ser Ala Leu Asn Pro Val Met Thr 
            100                 105                 110         

Val Glu Thr Gln Ile Val Asp Thr Ile Leu Ala His Arg Pro Asp Leu 
        115                 120                 125             

Ser Arg Gln Ala Ala Arg Glu Arg Ala Lys Glu Leu Leu Asp Leu Val 
    130                 135                 140                 

Arg Ile Asp Arg Lys His Leu Gln Ser Tyr Pro His Glu Leu Ser Gly 
145                 150                 155                 160 

Gly Met Arg Gln Arg Val Val Ile Ala Ile Ala Ile Ala Leu Asn Pro 
                165                 170                 175     

Ala Leu Val Ile Met Asp Glu Pro Thr Thr Ala Leu Asp Val Val Val 
            180                 185                 190         

Gln Arg Ser Ile Leu Asp Glu Ile Arg Arg Ile Gln Glu Gln Val Gly 
        195                 200                 205             

Phe Ala Ile Leu Phe Val Ser His Asp Phe Ser Leu Val Ala Glu Leu 
    210                 215                 220                 

Ala Ser Arg Val Ala Ile Met Tyr Ala Gly Arg Ile Val Glu Leu Thr 
225                 230                 235                 240 

Pro Ser His Leu Leu Asn Leu Ser Glu Arg His His Pro Tyr Thr Glu 
                245                 250                 255     

Gly Leu Leu Lys Ala Ile Pro Gln Leu Thr Ala Asp Glu Val Thr Ile 
            260                 265                 270         

Gln Gly Ile Gly Gly Tyr Pro Pro Asp Leu Gln Asp Leu Pro Pro Gly 
        275                 280                 285             

Cys Ala Phe His Pro Arg Cys Pro Tyr Ala Met Asp Val Cys Arg Arg 
    290                 295                 300                 

Val Arg Pro Ala Gln Val Arg Ala Gly Glu Lys Val Leu Glu Cys His 
305                 310                 315                 320 

Leu Phe Asn Glu Ala Glu Val Lys Ala His Val 
                325                 330     

<210>   571
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   571
Met Ala Glu Thr Arg Glu Pro Val Leu Gln Ile Glu Asp Leu Ser Val 
                5                   10                  15      

Ala Tyr Val Thr Asn Thr Gly Leu Val His Ala Val Ser Asp Val Asn 
            20                  25                  30          

Leu Thr Val His Arg Gly Glu Ile Val Gly Leu Val Gly Glu Ser Gly 
        35                  40                  45              

Ser Gly Lys Ser Thr Met Ala Tyr Thr Ile Met Arg Leu Leu Arg Gly 
    50                  55                  60                  

Asp Ala Val Val Thr Lys Gly Arg Val Arg Val Leu Gly Gln Asp Val 
65                  70                  75                  80  

Tyr Ala Leu Ser Glu Lys Glu Leu Arg Ala Phe Arg Trp Ser Lys Met 
                85                  90                  95      

Ser Met Val Phe Gln Ser Ala Met Ser Ala Leu Asn Pro Val Met Thr 
            100                 105                 110         

Val Glu Thr Gln Ile Val Asp Thr Ile Leu Ala His Arg Pro Asp Leu 
        115                 120                 125             

Ser Arg Gln Ala Ala Arg Glu Arg Ala Lys Glu Leu Leu Asp Leu Val 
    130                 135                 140                 

Arg Ile Asp Arg Lys His Leu Gln Ser Tyr Pro His Glu Leu Ser Gly 
145                 150                 155                 160 

Gly Met Arg Gln Arg Val Val Ile Ala Ile Ala Ile Ala Leu Asn Pro 
                165                 170                 175     

Ala Leu Val Ile Met Asp Glu Pro Thr Thr Ala Leu Asp Val Val Val 
            180                 185                 190         

Gln Arg Ser Ile Leu Asp Glu Ile Arg Arg Ile Gln Glu Gln Val Gly 
        195                 200                 205             

Phe Ala Ile Leu Phe Val Ser His Asp Phe Ser Leu Val Ala Glu Leu 
    210                 215                 220                 

Ala Ser Arg Val Ala Ile Met Tyr Ala Gly Arg Ile Val Glu Leu Thr 
225                 230                 235                 240 

Pro Ser His Leu Leu Asn Leu Ser Glu Arg His His Pro Tyr Thr Glu 
                245                 250                 255     

Gly Leu Leu Lys Ala Ile Pro Gln Leu Thr Ala Asp Glu Ile Thr Ile 
            260                 265                 270         

Gln Gly Ile Gly Gly Tyr Pro Pro Asp Leu Gln Asp Leu Pro Pro Gly 
        275                 280                 285             

Cys Ala Phe His Pro Arg Cys Pro Tyr Ala Met Asp Val Cys Arg Arg 
    290                 295                 300                 

Val Arg Pro Ala Gln Val Arg Ala Gly Glu Lys Val Leu Glu Cys His 
305                 310                 315                 320 

Leu Phe Asn Glu Ala Glu Val Lys Ala His Val 
                325                 330     

<210>   572
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   572
Met Ala Glu Thr Arg Glu Pro Val Leu Gln Leu Glu Asp Leu Ser Val 
                5                   10                  15      

Ala Tyr Val Thr Asn Thr Gly Leu Val His Ala Val Ser Asp Val Asn 
            20                  25                  30          

Leu Thr Val His Arg Gly Glu Ile Val Gly Leu Val Gly Glu Ser Gly 
        35                  40                  45              

Ser Gly Lys Ser Thr Met Ala Tyr Thr Ile Met Arg Leu Leu Arg Gly 
    50                  55                  60                  

Asp Ala Val Val Thr Lys Gly Arg Val Arg Val Leu Gly Gln Asp Val 
65                  70                  75                  80  

Tyr Ala Leu Ser Glu Lys Glu Leu Arg Ala Phe Arg Trp Ser Lys Met 
                85                  90                  95      

Ser Met Val Phe Gln Ser Ala Met Ser Ala Leu Asn Pro Val Met Thr 
            100                 105                 110         

Val Glu Thr Gln Ile Val Asp Thr Ile Leu Ala His Arg Pro Asp Leu 
        115                 120                 125             

Ser Arg Gln Ala Ala Arg Glu Arg Ala Lys Glu Leu Leu Asp Leu Val 
    130                 135                 140                 

Arg Ile Asp Arg Lys His Leu Gln Ser Tyr Pro His Glu Leu Ser Gly 
145                 150                 155                 160 

Gly Met Arg Gln Arg Val Val Ile Ala Ile Ala Ile Ala Leu Asn Pro 
                165                 170                 175     

Ala Leu Val Ile Met Asp Glu Pro Thr Thr Ala Leu Asp Val Val Val 
            180                 185                 190         

Gln Arg Ser Ile Leu Asp Glu Ile Arg Arg Ile Gln Glu Gln Val Gly 
        195                 200                 205             

Phe Ala Ile Leu Phe Val Ser His Asp Phe Ser Leu Val Ala Glu Leu 
    210                 215                 220                 

Ala Ser Arg Val Ala Ile Met Tyr Ala Gly Arg Ile Val Glu Leu Thr 
225                 230                 235                 240 

Pro Ser His Leu Leu Asn Leu Ser Glu Arg His His Pro Tyr Thr Glu 
                245                 250                 255     

Gly Leu Leu Lys Ala Ile Pro Gln Leu Thr Ala Asp Glu Val Thr Ile 
            260                 265                 270         

Gln Gly Ile Gly Gly Tyr Pro Pro Asp Leu Gln Asp Leu Pro Pro Gly 
        275                 280                 285             

Cys Ala Phe His Pro Arg Cys Pro Tyr Ala Met Asp Val Cys Arg Arg 
    290                 295                 300                 

Val Arg Pro Ala Gln Val Arg Ala Gly Glu Lys Val Leu Glu Cys His 
305                 310                 315                 320 

Leu Phe Asn Glu Ala Glu Val Lys Ala His Val 
                325                 330     

<210>   573
<211>   331
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 562

<400>   573
Met Ala Glu Thr Arg Glu Pro Val Leu Gln Ile Glu Asp Leu Ser Val 
                5                   10                  15      

Ala Tyr Val Thr Asn Thr Gly Leu Val His Ala Val Ser Asp Val Asn 
            20                  25                  30          

Leu Thr Val His Arg Gly Glu Ile Val Gly Leu Val Gly Glu Ser Gly 
        35                  40                  45              

Ser Gly Lys Ser Thr Met Ala Tyr Thr Ile Met Arg Leu Leu Arg Gly 
    50                  55                  60                  

Asp Ala Val Val Thr Lys Gly Arg Val Arg Val Leu Gly Gln Asp Val 
65                  70                  75                  80  

Tyr Ala Leu Ser Glu Lys Glu Ile Arg Ala Phe Arg Trp Ser Lys Met 
                85                  90                  95      

Ser Met Val Phe Gln Ser Ala Met Ser Ala Leu Asn Pro Val Met Thr 
            100                 105                 110         

Val Glu Thr Gln Ile Val Asp Thr Ile Leu Ala His Arg Pro Asp Leu 
        115                 120                 125             

Ser Arg Gln Ala Ala Arg Glu Arg Ala Lys Glu Leu Leu Asp Leu Val 
    130                 135                 140                 

Arg Ile Asp Arg Lys His Leu Gln Ser Tyr Pro His Glu Leu Ser Gly 
145                 150                 155                 160 

Gly Met Arg Gln Arg Val Val Ile Ala Ile Ala Ile Ala Leu Asn Pro 
                165                 170                 175     

Ala Leu Val Ile Met Asp Glu Pro Thr Thr Ala Leu Asp Val Val Val 
            180                 185                 190         

Gln Arg Ser Ile Leu Asp Glu Ile Arg Arg Ile Gln Glu Gln Val Gly 
        195                 200                 205             

Phe Ala Ile Leu Phe Val Ser His Asp Phe Ser Leu Val Ala Glu Leu 
    210                 215                 220                 

Ala Ser Arg Val Ala Ile Met Tyr Ala Gly Arg Ile Val Glu Leu Thr 
225                 230                 235                 240 

Pro Ser His Leu Leu Asn Leu Ser Glu Arg His His Pro Tyr Thr Glu 
                245                 250                 255     

Gly Leu Leu Lys Ala Ile Pro Gln Leu Thr Ala Asp Glu Val Thr Ile 
            260                 265                 270         

Gln Gly Ile Gly Gly Tyr Pro Pro Asp Leu Gln Asp Leu Pro Pro Gly 
        275                 280                 285             

Cys Ala Phe His Pro Arg Cys Pro Tyr Ala Met Asp Val Cys Arg Arg 
    290                 295                 300                 

Val Arg Pro Ala Gln Val Arg Ala Gly Glu Lys Val Leu Glu Cys His 
305                 310                 315                 320 

Leu Phe Asn Glu Ala Glu Val Lys Ala His Val 
                325                 330     

<210>   574
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   574
atggcagaga cgcgagaacc ggtgcttcag attgaggacc tgtccgtcgc ctacgtgacg       60

aacacggggc tcgtgcacgc ggtgagcgac gtgaacctga ccgtccatcg gggcgagatc      120

gtgggactgg ttggggagtc gggatcgggc aagtcgacga tggcgtacac catcatgcgg      180

ctgttgcgcg gcgacgcggt ggtcaccaag ggccgcgtgc gggtgttggg ccaggatgtg      240

tacgcgctgt ccgaaaagga actgagggcg tttcgctgga gcaagatgtc catggtgttc      300

cagagcgcga tgagcgccct gaacccggtg atgacggtgg agacgcagat cgtcgacacc      360

atcttggcac accggccgga tctgtcgcgg caggcggcgc gggagcgggc gaaggagttg      420

ctcgatctcg tccgaatcga ccggaaacac ctgcagagct atccgcacga gctttccggc      480

ggcatgcgcc agcggattgt gatcgccatc gcgattgcgc tcaatcccgc gctcgtcatc      540

atggatgagc cgacgaccgc gcttgacgtt gtggtgcagc ggtccattct ggacgaaatc      600

cggcgcatcc aggagcaggt gggcttcgcc atcttgtttg tcagccacga cttcagcctg      660

gtggcggagc tcgcgtcccg cgtcgccatc atgtacgcgg gccgcatcgt cgaactcacg      720

ccgagccacc tgttgaacct gtccgagcgg caccacccgt acacggaggg gctcctgaag      780

gccattcctc agctgaccgc ggacgaggtg accatccagg ggattggcgg atacccaccg      840

gatctgcagg acctgccgcc cggctgcgcg tttcatccgc gctgcccgta cgccatggac      900

gtctgcaggc gcgtgcgccc ggcgcaggtg cgggcgggcg agaaggtgct ggagtgccac      960

ctgttcaacg aggcggaggt gaaggcccat gtctga                                996


<210>   575
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   575
atggcagaga cgcgagaacc ggtgcttcag attgaggacc tgtccgtcgc ctacgtgacg       60

aacacggggc tcgtgcacgc ggtgagcgac gtgaacctga ccgtccatcg gggcgagtta      120

gtgggactgg ttggggagtc gggatcgggc aagtcgacga tggcgtacac catcatgcgg      180

ctgttgcgcg gcgacgcggt ggtcaccaag ggccgcgtgc gggtgttggg ccaggatgtg      240

tacgcgctgt ccgaaaagga actgagggcg tttcgctgga gcaagatgtc catggtgttc      300

cagagcgcga tgagcgccct gaacccggtg atgacggtgg agacgcagat cgtcgacacc      360

atcttggcac accggccgga tctgtcgcgg caggcggcgc gggagcgggc gaaggagttg      420

ctcgatctcg tccgaatcga ccggaaacac ctgcagagct atccgcacga gctttccggc      480

ggcatgcgcc agcgggtcgt gatcgccatc gcgattgcgc tcaatcccgc gctcgtcatc      540

atggatgagc cgacgaccgc gcttgacgtt gtggtgcagc ggtccattct ggacgaaatc      600

cggcgcatcc aggagcaggt gggcttcgcc atcttgtttg tcagccacga cttcagcctg      660

gtggcggagc tcgcgtcccg cgtcgccatc atgtacgcgg gccgcatcgt cgaactcacg      720

ccgagccacc tgttgaacct gtccgagcgg caccacccgt acacggaggg gctcctgaag      780

gccattcctc agctgaccgc ggacgaggtg accatccagg ggattggcgg atacccaccg      840

gatctgcagg acctgccgcc cggctgcgcg tttcatccgc gctgcccgta cgccatggac      900

gtctgcaggc gcgtgcgccc ggcgcaggtg cgggcgggcg agaaggtgct ggagtgccac      960

ctgttcaacg aggcggaggt gaaggcccat gtctga                                996


<210>   576
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   576
atggcagaga cgcgagaacc ggtgcttcag attgaggacc tgtccgtcgc ctacgtgacg       60

aacacggggc tcgtgcacgc ggtgagcgac gtgaacctga ccgtccatcg gggcgagatc      120

gtgggactgg ttggggagtc gggatcgggc aagtcgacga tggcgtacac catcatgcgg      180

ctgttgcgcg gcgacgcggt ggtcaccaag ggccgcgtgc gggtgttggg ccaggatgtg      240

tacgcgctgt ccgaaaagga actgagggcg tttcgctgga gcaagatgtc catggtgttc      300

cagagcgcga tgagcgccct gaacccggtg atgacggtgg agacgcagat cgtcgacacc      360

atcttggcac accggccgga tctgtcgcgg caggcggcgc gggagcgggc gaaggagttg      420

ctcgatctcg tccgaatcga ccggaaacac ctgcagagct atccgcacga gctttccggc      480

ggcatgcgcc agcgggtcgt gatcgccatc gcgattgcgc tcaatcccgc gctcgtcatc      540

atggatgagc cgacgaccgc gcttgacgtt gtggtgcagc ggtccattct ggacgaaatc      600

cggcgcatcc aggagcaggt gggcttcgcc atcttgtttg tcagccacga cttcagcctg      660

gtggcggagc tcgcgtcccg cgtcgccatc atgtacgcgg gccgcatcgt cgaactcacg      720

ccgagccacc tgttgaacct gtccgagcgg caccacccgt acacggaggg gctcctgaag      780

gccattcctc agctgaccgc ggacgagatt accatccagg ggattggcgg atacccaccg      840

gatctgcagg acctgccgcc cggctgcgcg tttcatccgc gctgcccgta cgccatggac      900

gtctgcaggc gcgtgcgccc ggcgcaggtg cgggcgggcg agaaggtgct ggagtgccac      960

ctgttcaacg aggcggaggt gaaggcccat gtctga                                996


<210>   577
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   577
atggcagaga cgcgagaacc ggtgcttcag ttagaggacc tgtccgtcgc ctacgtgacg       60

aacacggggc tcgtgcacgc ggtgagcgac gtgaacctga ccgtccatcg gggcgagatc      120

gtgggactgg ttggggagtc gggatcgggc aagtcgacga tggcgtacac catcatgcgg      180

ctgttgcgcg gcgacgcggt ggtcaccaag ggccgcgtgc gggtgttggg ccaggatgtg      240

tacgcgctgt ccgaaaagga actgagggcg tttcgctgga gcaagatgtc catggtgttc      300

cagagcgcga tgagcgccct gaacccggtg atgacggtgg agacgcagat cgtcgacacc      360

atcttggcac accggccgga tctgtcgcgg caggcggcgc gggagcgggc gaaggagttg      420

ctcgatctcg tccgaatcga ccggaaacac ctgcagagct atccgcacga gctttccggc      480

ggcatgcgcc agcgggtcgt gatcgccatc gcgattgcgc tcaatcccgc gctcgtcatc      540

atggatgagc cgacgaccgc gcttgacgtt gtggtgcagc ggtccattct ggacgaaatc      600

cggcgcatcc aggagcaggt gggcttcgcc atcttgtttg tcagccacga cttcagcctg      660

gtggcggagc tcgcgtcccg cgtcgccatc atgtacgcgg gccgcatcgt cgaactcacg      720

ccgagccacc tgttgaacct gtccgagcgg caccacccgt acacggaggg gctcctgaag      780

gccattcctc agctgaccgc ggacgaggtg accatccagg ggattggcgg atacccaccg      840

gatctgcagg acctgccgcc cggctgcgcg tttcatccgc gctgcccgta cgccatggac      900

gtctgcaggc gcgtgcgccc ggcgcaggtg cgggcgggcg agaaggtgct ggagtgccac      960

ctgttcaacg aggcggaggt gaaggcccat gtctga                                996


<210>   578
<211>   996
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 563

<400>   578
atggcagaga cgcgagaacc ggtgcttcag attgaggacc tgtccgtcgc ctacgtgacg       60

aacacggggc tcgtgcacgc ggtgagcgac gtgaacctga ccgtccatcg gggcgagatc      120

gtgggactgg ttggggagtc gggatcgggc aagtcgacga tggcgtacac catcatgcgg      180

ctgttgcgcg gcgacgcggt ggtcaccaag ggccgcgtgc gggtgttggg ccaggatgtg      240

tacgcgctgt ccgaaaagga aattagggcg tttcgctgga gcaagatgtc catggtgttc      300

cagagcgcga tgagcgccct gaacccggtg atgacggtgg agacgcagat cgtcgacacc      360

atcttggcac accggccgga tctgtcgcgg caggcggcgc gggagcgggc gaaggagttg      420

ctcgatctcg tccgaatcga ccggaaacac ctgcagagct atccgcacga gctttccggc      480

ggcatgcgcc agcgggtcgt gatcgccatc gcgattgcgc tcaatcccgc gctcgtcatc      540

atggatgagc cgacgaccgc gcttgacgtt gtggtgcagc ggtccattct ggacgaaatc      600

cggcgcatcc aggagcaggt gggcttcgcc atcttgtttg tcagccacga cttcagcctg      660

gtggcggagc tcgcgtcccg cgtcgccatc atgtacgcgg gccgcatcgt cgaactcacg      720

ccgagccacc tgttgaacct gtccgagcgg caccacccgt acacggaggg gctcctgaag      780

gccattcctc agctgaccgc ggacgaggtg accatccagg ggattggcgg atacccaccg      840

gatctgcagg acctgccgcc cggctgcgcg tttcatccgc gctgcccgta cgccatggac      900

gtctgcaggc gcgtgcgccc ggcgcaggtg cgggcgggcg agaaggtgct ggagtgccac      960

ctgttcaacg aggcggaggt gaaggcccat gtctga                                996


<210>   579
<211>   352
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   579
Met Lys Leu Arg Thr Lys Lys Ala Lys His Lys Ala Leu Gly Gly Leu 
                5                   10                  15      

Ala Ala Ala Ala Leu Val Ala Thr Val Thr Gly Cys Gly Thr Val Ala 
            20                  25                  30          

Thr Thr Ala Ser Thr Pro Asn Ser Asn Ala Gly Ser Ala Ala Ala Ser 
        35                  40                  45              

Ser Ser Lys Pro Ile Lys Val Ala Phe Ile Pro Lys Glu Ile Gly Ile 
    50                  55                  60                  

Pro Tyr Phe Thr Gly Ala Asp Gln Gly Ala Gln Ser Val Ala Pro Lys 
65                  70                  75                  80  

Leu His Ile Gln Leu Thr Tyr Asn Gly Pro Thr Gln Ala Ser Ala Ala 
                85                  90                  95      

Asp Gln Val Ser Met Ile Asn Ser Tyr Val Ala Gln Gly Tyr Asn Val 
            100                 105                 110         

Ile Ala Val Ser Ala Asn Asp Pro Thr Ser Leu Ala Pro Ala Leu Glu 
        115                 120                 125             

Ser Ala Met Arg Arg Gly Val Lys Val Ile Thr Trp Asp Ser Asp Val 
    130                 135                 140                 

Ile Pro Ser Ala Arg Gln Phe Phe Val Asp Gln Ala Thr Ala Gln Gly 
145                 150                 155                 160 

Ile Gly Thr Thr Leu Val Gln Ile Thr Ala Glu His Phe Lys Ser Gln 
                165                 170                 175     

Lys Asn Val Glu Val Gly Ile Leu Ser Ser Thr Pro Thr Asn Pro Asn 
            180                 185                 190         

Gln Asn Ala Trp Ile Ala Val Met Lys Gln Ala Ile Gln Ser Lys Tyr 
        195                 200                 205             

Lys Asn Leu His Ile Val Thr Ile Gln Tyr Asp Gln Glu Gln Pro Asp 
    210                 215                 220                 

Val Gly Leu Thr Ala Ala Glu Asn Met Leu Arg Ala Tyr Pro Gln Met 
225                 230                 235                 240 

Lys Ala Ile Ile Ser Pro Asp Ser Val Gly Val Pro Ala Ala Ala Glu 
                245                 250                 255     

Ala Val Glu Lys Leu Gly Leu Lys Gly Lys Val Phe Val Thr Gly Leu 
            260                 265                 270         

Ala Asp Pro Ile Gln Met Lys Gln Tyr Val Asn Asp Gly Thr Val Gln 
        275                 280                 285             

Glu Phe Val Leu Trp Asp Val Pro Lys Leu Gly Ala Leu Thr Met Tyr 
    290                 295                 300                 

Val Ala Arg Ala Val Val Asp Gly Thr Met Pro Val Asn Gly Thr Phe 
305                 310                 315                 320 

Lys Cys Ala Leu Gly Ser Phe Lys Val Gln Asn Arg Val Val Leu Leu 
                325                 330                 335     

Gly Asn Pro Thr Ile Phe Asn Lys Ser Asn Ile Asn Asn Ala Asn Tyr 
            340                 345                 350         

<210>   580
<211>   1059
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   580
atgaagctcc gcacgaaaaa ggcgaaacac aaggctctgg gtggattggc agccgcagcg       60

ctcgtggcca ctgtgacggg gtgtggtact gtcgcgacca ccgcgtccac gcccaattcg      120

aatgccggga gcgcagcagc ctcgtcgtcc aaaccgatca aggttgcctt tatcccgaag      180

gaaatcggca taccgtactt cacaggcgcg gatcaagggg cccaatctgt tgcaccgaag      240

cttcacattc aactcacgta taacgggccg acgcaggcaa gcgcagctga tcaggtttcg      300

atgatcaaca gctacgttgc ccaaggttac aacgtcattg ctgtgtccgc gaatgatccc      360

acttctttgg ccccagcgtt ggaatctgca atgcgcaggg gcgtgaaggt cattacgtgg      420

gactctgatg tcatcccgtc ggcgcgccag ttctttgtcg accaggcgac agcgcaaggc      480

attggcacca ctcttgtaca gatcacggcg gaacatttta agagccagaa gaatgtcgag      540

gttggcattc tgtcgtccac cccgacaaat ccgaatcaga acgcctggat cgcggtcatg      600

aaacaggcga ttcagagcaa gtacaagaac ttgcatatcg taaccattca gtacgatcag      660

gagcaacctg acgtgggatt gacggccgct gaaaacatgt tgcgagccta tccacagatg      720

aaggcgataa tatctccgga ttctgttgga gtccctgctg cagcagaagc cgtcgaaaaa      780

ctgggcctta agggtaaagt gttcgttacc ggactcgcgg atccaattca aatgaagcaa      840

tatgtgaatg acgggactgt ccaggaattc gtgctgtggg acgtgccgaa actgggtgct      900

ctcaccatgt atgtcgctcg ggccgtggta gatggtacaa tgcctgtaaa cggcacgttc      960

aagtgtgcgt tgggttcgtt caaggtgcaa aatagagttg tacttttggg caatccaaca     1020

atatttaaca aatcgaacat caacaatgcg aattactga                            1059


<210>   581
<211>   301
<212>   PRT
<213>   Rubrobacter xylanophilus DSM 9941

<400>   581
Pro Asn Lys Ile Cys Met Met Pro Lys Leu Val Gly Ile Pro Tyr Phe 
                5                   10                  15      

Asn Ala Ala Glu Lys Gly Ala Arg Glu Ala Ala Arg Glu Leu Gly Val 
            20                  25                  30          

Asp Leu Val Tyr Asp Gly Pro Thr Glu Ala Leu Ala Ala Asp Gln Val 
        35                  40                  45              

Glu Phe Ile Glu Gln Phe Ile Gln Gln Gln Cys Asp Ala Ile Thr Val 
    50                  55                  60                  

Ala Ala Asn Asp Pro Asp Ala Leu Ala Pro Ala Met Lys Lys Ala Lys 
65                  70                  75                  80  

Gln Ala Gly Ile Ala Thr Gly Ala Trp Asp Ala Asp Val Ala Glu Asp 
                85                  90                  95      

Ala Arg Asp Val Phe Val Asn Gln Ala Thr Phe Gln Ala Ile Gly Tyr 
            100                 105                 110         

Lys Leu Val Asp Val Met Ala Glu Gln Thr Gly Gly Lys Gly Lys Phe 
        115                 120                 125             

Leu Val Val Thr Gly Ser Leu Thr Ala Pro Asn Gln Asn Ala Trp Leu 
    130                 135                 140                 

Lys Glu Met Arg Glu Arg Met Arg Gln Lys Tyr Pro Gln Met Glu Ile 
145                 150                 155                 160 

Ala Ser Val Gln Pro Gly Glu Glu Asp Leu Gln Lys Gly Ile Asp Ile 
                165                 170                 175     

Thr Lys Asp Tyr Leu Arg Ala Asn Pro Asp Thr Ala Gly Val Phe Gly 
            180                 185                 190         

Ile Thr Ser Val Ala Leu Pro Gly Ala Ala Glu Ala Val Gln Gln Met 
        195                 200                 205             

Gly Leu Lys Gly Glu Val Ala Val Thr Gly Leu Ser Thr Pro Asn Glu 
    210                 215                 220                 

Met Lys Pro Tyr Val Lys Ser Gly Val Val Glu Lys Phe Val Leu Trp 
225                 230                 235                 240 

Asn Pro Val Asp Leu Gly Tyr Leu Ala Val Tyr Val Ala Asn Ala Gln 
                245                 250                 255     

Val Glu Gly Thr Leu Pro Glu Ser Gly Thr Phe Lys Ala Gly Arg Leu 
            260                 265                 270         

Gly Glu Val Lys Met Leu Ala Pro Asp Glu Val Leu Leu Gly Pro Pro 
        275                 280                 285             

Leu Val Phe Thr Arg Glu Asn Ile Asp Glu Tyr Asp Phe 
    290                 295                 300     

<210>   582
<211>   312
<212>   PRT
<213>   Haemophilus somnus 2336

<400>   582
Lys Val Ala Phe Ile Pro Lys Leu Val Gly Val Gly Phe Phe Thr Ser 
                5                   10                  15      

Gly Gly Gln Gly Ala Val Glu Met Gly Lys Lys Leu Gly Leu Asp Val 
            20                  25                  30          

Thr Tyr Asp Gly Pro Ala Glu Pro Ser Val Ser Asn Gln Val Gln Met 
        35                  40                  45              

Ile Asn Asn Phe Val Asn Gln Gly Tyr Asn Ala Ile Ile Val Ser Ala 
    50                  55                  60                  

Val Ser Pro Asp Gly Leu Cys Ser Thr Leu Lys Arg Ala Met Lys Lys 
65                  70                  75                  80  

Gly Val Lys Val Leu Thr Trp Asp Ser Asp Thr Gln Pro Glu Cys Arg 
                85                  90                  95      

Ser Tyr Tyr Ile Asn Gln Gly Thr Pro Thr Gln Leu Gly Ser Met Leu 
            100                 105                 110         

Val Glu Met Val Ser Ser Gln Ile Ser Lys Pro Lys Ala Lys Val Ala 
        115                 120                 125             

Phe Phe Tyr Ser Ser Pro Thr Val Thr Asp Gln Asn Gln Trp Val Lys 
    130                 135                 140                 

Glu Ala Lys Ala Lys Ile Glu Lys Glu His Pro Lys Trp Glu Ile Val 
145                 150                 155                 160 

Thr Thr Gln Phe Gly Tyr Asn Asp Ala Ile Lys Ser Leu Gln Thr Ala 
                165                 170                 175     

Glu Gly Ile Leu Lys Ala Tyr Pro Asp Leu Asp Ala Ile Ile Ala Pro 
            180                 185                 190         

Asp Ala Asn Ala Leu Pro Ala Ala Ala Gln Ala Val Glu Asn Leu Lys 
        195                 200                 205             

Arg Gln Gly Thr Ile Val Val Gly Phe Ser Thr Pro Asn Val Met Arg 
    210                 215                 220                 

Pro Tyr Val Lys Arg Gly Thr Val Asn Gln Phe Gly Leu Trp Asp Val 
225                 230                 235                 240 

Val Lys Gln Gly Gln Leu Ser Val Ala Val Ala Asn Glu Leu Leu Lys 
                245                 250                 255     

Gly Asn Ser Leu Lys Val Gly Asp Lys Leu Asn Val Asp Gly Ile Gly 
            260                 265                 270         

Glu Val Glu Val Ser Ala Asn Lys Val Gln Gly Tyr Glu Phe Glu Ala 
        275                 280                 285             

Lys Gly Asn Gly Ile Val Leu Leu Pro Glu Arg Val Val Phe Thr Lys 
    290                 295                 300                 

Asp Asn Ile Asp Asn Tyr Asp Phe 
305                 310         

<210>   583
<211>   312
<212>   PRT
<213>   Klebsiella pneumoniae subsp. pneumoniae MGH 78578

<400>   583
Arg Ile Ala Phe Ile Pro Lys Leu Val Gly Val Gly Phe Phe Thr Ser 
                5                   10                  15      

Gly Gly Asn Gly Ala Lys Glu Ala Gly Lys Ala Leu Gly Val Asp Val 
            20                  25                  30          

Thr Tyr Asp Gly Pro Thr Glu Pro Ser Val Ser Gly Gln Val Gln Leu 
        35                  40                  45              

Ile Asn Asn Phe Val Asn Gln Gly Tyr Asn Ala Ile Ile Val Ser Ala 
    50                  55                  60                  

Val Ser Pro Asp Gly Leu Cys Pro Ala Leu Lys Arg Ala Met Gln Arg 
65                  70                  75                  80  

Gly Val Lys Val Leu Thr Trp Asp Ser Asp Thr Lys Pro Glu Cys Arg 
                85                  90                  95      

Ser Ile Tyr Ile Asn Gln Gly Thr Pro Gln Gln Leu Gly Gly Leu Leu 
            100                 105                 110         

Val Glu Met Ala Glu Lys Gln Val Ser Lys Pro Ala Ala Lys Val Ala 
        115                 120                 125             

Phe Phe Tyr Ser Ser Pro Thr Val Thr Asp Gln Asn Gln Trp Val Lys 
    130                 135                 140                 

Glu Ala Lys Ala Lys Ile Glu Lys Glu His Pro Gln Trp Gln Ile Val 
145                 150                 155                 160 

Thr Thr Gln Phe Gly Tyr Asn Asp Ala Thr Lys Ser Leu Gln Thr Ala 
                165                 170                 175     

Glu Gly Ile Leu Lys Ala Tyr Pro Asp Leu Asp Ala Ile Ile Ala Pro 
            180                 185                 190         

Asp Ala Asn Ala Leu Pro Ala Ala Ala Gln Ala Ala Glu Asn Leu Lys 
        195                 200                 205             

Arg Gln Gly Val Ala Ile Val Gly Phe Ser Thr Pro Asn Val Met Arg 
    210                 215                 220                 

Pro Tyr Val Glu Arg Gly Thr Val Lys Ala Phe Gly Leu Trp Asp Val 
225                 230                 235                 240 

Val Lys Gln Gly Lys Ile Ala Val Asn Val Ala Asp Arg Leu Leu Lys 
                245                 250                 255     

Lys Gly Asp Leu Asn Val Gly Asp Ser Val Glu Val Lys Asp Ile Gly 
            260                 265                 270         

Ser Leu Lys Val Glu Pro Asn Ser Val Gln Gly Tyr Gln Tyr Glu Ala 
        275                 280                 285             

Lys Gly Asn Gly Ile Val Leu Leu Pro Glu Arg Val Val Phe Ser Lys 
    290                 295                 300                 

Glu Asn Ile Asn Asn Tyr Asp Phe 
305                 310         

<210>   584
<211>   312
<212>   PRT
<213>   Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7

<400>   584
Arg Ile Ala Phe Ile Pro Lys Leu Val Gly Val Gly Phe Phe Thr Ser 
                5                   10                  15      

Gly Gly Asn Gly Ala Gln Glu Ala Gly Lys Ala Leu Gly Ile Asp Val 
            20                  25                  30          

Thr Tyr Asp Gly Pro Thr Glu Pro Ser Val Ser Gly Gln Val Gln Leu 
        35                  40                  45              

Val Asn Asn Phe Val Asn Gln Gly Tyr Asp Ala Ile Ile Val Ser Ala 
    50                  55                  60                  

Val Ser Pro Asp Gly Leu Cys Pro Ala Leu Lys Arg Ala Met Gln Arg 
65                  70                  75                  80  

Gly Val Lys Ile Leu Thr Trp Asp Ser Asp Thr Lys Pro Glu Cys Arg 
                85                  90                  95      

Ser Tyr Tyr Ile Asn Gln Gly Thr Pro Lys Gln Leu Gly Ser Met Leu 
            100                 105                 110         

Val Glu Met Ala Ala His Gln Val Asp Lys Glu Lys Ala Lys Val Ala 
        115                 120                 125             

Phe Phe Tyr Ser Ser Pro Thr Val Thr Asp Gln Asn Gln Trp Val Lys 
    130                 135                 140                 

Glu Ala Lys Ala Lys Ile Ser Gln Glu His Pro Gly Trp Glu Ile Val 
145                 150                 155                 160 

Thr Thr Gln Phe Gly Tyr Asn Asp Ala Thr Lys Ser Leu Gln Thr Ala 
                165                 170                 175     

Glu Gly Ile Ile Lys Ala Tyr Pro Asp Leu Asp Ala Ile Ile Ala Pro 
            180                 185                 190         

Asp Ala Asn Ala Leu Pro Ala Ala Ala Gln Ala Ala Glu Asn Leu Lys 
        195                 200                 205             

Arg Asn Asn Leu Ala Ile Val Gly Phe Ser Thr Pro Asn Val Met Arg 
    210                 215                 220                 

Pro Tyr Val Gln Arg Gly Thr Val Lys Glu Phe Gly Leu Trp Asp Val 
225                 230                 235                 240 

Val Gln Gln Gly Lys Ile Ser Val Tyr Val Ala Asn Ala Leu Leu Lys 
                245                 250                 255     

Asn Met Pro Met Asn Val Gly Asp Ser Leu Asp Ile Pro Gly Ile Gly 
            260                 265                 270         

Lys Val Thr Val Ser Pro Asn Ser Glu Gln Gly Tyr His Tyr Glu Ala 
        275                 280                 285             

Lys Gly Asn Gly Ile Val Leu Leu Pro Glu Arg Val Ile Phe Asn Lys 
    290                 295                 300                 

Asn Asn Ile Asp Lys Tyr Asp Phe 
305                 310         

<210>   585
<211>   314
<212>   PRT
<213>   Rhodobacter sphaeroides 2.4.1

<400>   585
Glu Ile Ala Phe Ile Pro Lys Leu Val Gly Val Gly Phe Phe Thr Ser 
                5                   10                  15      

Gly Gly Asn Gly Ala Met Lys Met Gly Glu Glu Leu Gly Val Lys Val 
            20                  25                  30          

Thr Tyr Asp Gly Pro Thr Glu Pro Ser Val Ser Gly Gln Val Gln Phe 
        35                  40                  45              

Val Asn Asn Phe Val Asn Gln Gly Tyr Gly Ala Ile Val Leu Ser Ser 
    50                  55                  60                  

Val Ser Pro Asp Gly Leu Cys Pro Ala Leu Lys Gln Ala Met Ala Arg 
65                  70                  75                  80  

Asp Val Leu Val Met Thr Trp Asp Ser Asp Val Asn Pro Asp Cys Arg 
                85                  90                  95      

Ser Tyr Tyr Ile Asn Gln Gly Thr Pro Glu Gln Leu Gly Gly Leu Leu 
            100                 105                 110         

Val Asp Met Ala Asn Asp Gly Leu Glu Gly Lys Glu Lys Ala Lys Val 
        115                 120                 125             

Ala Phe Phe Tyr Ser Ser Pro Thr Val Thr Asp Gln Asn Ala Trp Ala 
    130                 135                 140                 

Glu Ala Ala Lys Ala Arg Ile Ala Ala Asp His Pro Gly Trp Glu Ile 
145                 150                 155                 160 

Val Thr Thr Gln Tyr Gly Tyr Asn Asp Ala Gln Lys Ser Leu Gln Thr 
                165                 170                 175     

Ala Glu Ser Ile Leu Ser Ala Tyr Pro Asp Leu Asp Ala Ile Ile Ala 
            180                 185                 190         

Pro Asp Ala Asn Ala Leu Pro Ala Ser Ala Gln Ala Ala Glu Asn Leu 
        195                 200                 205             

Gly Arg Ala Gly Glu Val Thr Ile Val Gly Phe Ser Thr Pro Asn Val 
    210                 215                 220                 

Met Arg Pro Tyr Val Lys Arg Gly Thr Val Glu Arg Phe Gly Leu Trp 
225                 230                 235                 240 

Asp Val Thr Gln Gln Gly Ala Ile Ser Val Ala Val Ala Ala His Val 
                245                 250                 255     

Leu Lys Asp Gly Pro Leu Asn Val Gly Asp Ser Leu Glu Val Pro Gly 
            260                 265                 270         

Ile Gly Ser Val Glu Val Ser Pro Asn Ser Val Gln Gly Tyr Asp Tyr 
        275                 280                 285             

Glu Ala Glu Gly Asn Gly Ile Ile Leu Leu Pro Glu Arg Thr Val Phe 
    290                 295                 300                 

Thr Ala Glu Asn Ile Asp Asn Phe Asp Phe 
305                 310                 

<210>   586
<211>   352
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   586
Met Lys Leu Arg Thr Lys Lys Ala Lys His Lys Ala Leu Gly Gly Leu 
                5                   10                  15      

Ala Ala Ala Ala Leu Val Ala Thr Val Thr Gly Cys Gly Thr Val Ala 
            20                  25                  30          

Thr Thr Ala Ser Thr Pro Asn Ser Asn Ala Gly Ser Ala Ala Ala Ser 
        35                  40                  45              

Ser Ser Lys Pro Ile Lys Val Ala Phe Ile Pro Lys Glu Ile Gly Ile 
    50                  55                  60                  

Pro Tyr Phe Thr Gly Ala Asp Gln Gly Ala Gln Ser Val Ala Pro Lys 
65                  70                  75                  80  

Leu His Ile Gln Leu Thr Tyr Asn Gly Pro Thr Asn Ala Ser Ala Ala 
                85                  90                  95      

Asp Gln Val Ser Met Ile Asn Ser Tyr Val Ala Gln Gly Tyr Asn Val 
            100                 105                 110         

Ile Ala Val Ser Ala Asn Asp Pro Thr Ser Leu Ala Pro Ala Leu Glu 
        115                 120                 125             

Ser Ala Met Arg Arg Gly Val Lys Val Ile Thr Trp Asp Ser Asp Val 
    130                 135                 140                 

Ile Pro Ser Ala Arg Gln Phe Phe Val Asp Gln Ala Thr Ala Gln Gly 
145                 150                 155                 160 

Ile Gly Thr Thr Leu Val Gln Ile Thr Ala Glu His Phe Lys Ser Gln 
                165                 170                 175     

Lys Asn Val Glu Val Gly Ile Leu Ser Ser Thr Pro Thr Asn Pro Asn 
            180                 185                 190         

Gln Asn Ala Trp Ile Ala Val Met Lys Gln Ala Ile Gln Ser Lys Tyr 
        195                 200                 205             

Lys Asn Leu His Ile Val Thr Ile Gln Tyr Asp Gln Glu Gln Pro Asp 
    210                 215                 220                 

Val Gly Leu Thr Ala Ala Glu Asn Met Leu Arg Ala Tyr Pro Gln Met 
225                 230                 235                 240 

Lys Ala Ile Ile Ser Pro Asp Ser Val Gly Val Pro Ala Ala Ala Glu 
                245                 250                 255     

Ala Val Glu Lys Leu Gly Leu Lys Gly Lys Val Phe Val Thr Gly Leu 
            260                 265                 270         

Ala Asp Pro Ile Gln Met Lys Gln Tyr Val Asn Asp Gly Thr Val Gln 
        275                 280                 285             

Glu Phe Val Leu Trp Asp Val Pro Lys Leu Gly Ala Leu Thr Met Tyr 
    290                 295                 300                 

Val Ala Arg Ala Val Val Asp Gly Thr Met Pro Val Asn Gly Thr Phe 
305                 310                 315                 320 

Lys Cys Ala Leu Gly Ser Phe Lys Val Gln Asn Arg Val Val Leu Leu 
                325                 330                 335     

Gly Asn Pro Thr Ile Phe Asn Lys Ser Asn Ile Asn Asn Ala Asn Tyr 
            340                 345                 350         

<210>   587
<211>   352
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   587
Met Lys Leu Arg Thr Lys Lys Ala Lys His Lys Ala Leu Gly Gly Leu 
                5                   10                  15      

Ala Ala Ala Ala Leu Val Ala Thr Val Thr Gly Cys Gly Thr Val Ala 
            20                  25                  30          

Thr Thr Ala Ser Thr Pro Asn Ser Asn Ala Gly Ser Ala Ala Ala Ser 
        35                  40                  45              

Ser Ser Lys Pro Ile Lys Val Ala Phe Ile Pro Lys Glu Ile Gly Ile 
    50                  55                  60                  

Pro Tyr Phe Thr Gly Ala Asp Gln Gly Ala Gln Ser Val Ala Pro Lys 
65                  70                  75                  80  

Leu His Ile Gln Leu Thr Tyr Asn Gly Pro Thr Gln Ala Ser Ala Ala 
                85                  90                  95      

Asp Gln Val Ser Met Ile Gln Ser Tyr Val Ala Gln Gly Tyr Asn Val 
            100                 105                 110         

Ile Ala Val Ser Ala Asn Asp Pro Thr Ser Leu Ala Pro Ala Leu Glu 
        115                 120                 125             

Ser Ala Met Arg Arg Gly Val Lys Val Ile Thr Trp Asp Ser Asp Val 
    130                 135                 140                 

Ile Pro Ser Ala Arg Gln Phe Phe Val Asp Gln Ala Thr Ala Gln Gly 
145                 150                 155                 160 

Ile Gly Thr Thr Leu Val Gln Ile Thr Ala Glu His Phe Lys Ser Gln 
                165                 170                 175     

Lys Asn Val Glu Val Gly Ile Leu Ser Ser Thr Pro Thr Asn Pro Asn 
            180                 185                 190         

Gln Asn Ala Trp Ile Ala Val Met Lys Gln Ala Ile Gln Ser Lys Tyr 
        195                 200                 205             

Lys Asn Leu His Ile Val Thr Ile Gln Tyr Asp Gln Glu Gln Pro Asp 
    210                 215                 220                 

Val Gly Leu Thr Ala Ala Glu Asn Met Leu Arg Ala Tyr Pro Gln Met 
225                 230                 235                 240 

Lys Ala Ile Ile Ser Pro Asp Ser Val Gly Val Pro Ala Ala Ala Glu 
                245                 250                 255     

Ala Val Glu Lys Leu Gly Leu Lys Gly Lys Val Phe Val Thr Gly Leu 
            260                 265                 270         

Ala Asp Pro Ile Gln Met Lys Gln Tyr Val Asn Asp Gly Thr Val Gln 
        275                 280                 285             

Glu Phe Val Leu Trp Asp Val Pro Lys Leu Gly Ala Leu Thr Met Tyr 
    290                 295                 300                 

Val Ala Arg Ala Val Val Asp Gly Thr Met Pro Val Asn Gly Thr Phe 
305                 310                 315                 320 

Lys Cys Ala Leu Gly Ser Phe Lys Val Gln Asn Arg Val Val Leu Leu 
                325                 330                 335     

Gly Asn Pro Thr Ile Phe Asn Lys Ser Asn Ile Asn Asn Ala Asn Tyr 
            340                 345                 350         

<210>   588
<211>   352
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   588
Met Lys Leu Arg Thr Lys Lys Ala Lys His Lys Ala Leu Gly Gly Leu 
                5                   10                  15      

Ala Ala Ala Ala Leu Val Ala Thr Val Thr Gly Cys Gly Thr Val Ala 
            20                  25                  30          

Thr Thr Ala Ser Thr Pro Asn Ser Asn Ala Gly Ser Ala Ala Ala Ser 
        35                  40                  45              

Ser Ser Lys Pro Ile Lys Val Ala Phe Ile Pro Lys Glu Ile Gly Ile 
    50                  55                  60                  

Pro Tyr Phe Thr Gly Ala Asp Gln Gly Ala Gln Ser Val Ala Pro Lys 
65                  70                  75                  80  

Leu His Ile Gln Leu Thr Tyr Asn Gly Pro Thr Gln Ala Ser Ala Ala 
                85                  90                  95      

Asp Gln Val Ser Met Ile Asn Ser Tyr Val Ala Gln Gly Tyr Asn Val 
            100                 105                 110         

Ile Ala Val Ser Ala Asn Asp Pro Thr Ser Leu Ala Pro Ala Leu Glu 
        115                 120                 125             

Ser Ala Met Arg Arg Gly Val Lys Val Ile Thr Trp Asp Ser Asp Val 
    130                 135                 140                 

Ile Pro Ser Ala Arg Gln Phe Phe Val Asp Gln Ala Thr Ala Gln Gly 
145                 150                 155                 160 

Ile Gly Thr Thr Leu Val Gln Ile Thr Ala Asp His Phe Lys Ser Gln 
                165                 170                 175     

Lys Asn Val Glu Val Gly Ile Leu Ser Ser Thr Pro Thr Asn Pro Asn 
            180                 185                 190         

Gln Asn Ala Trp Ile Ala Val Met Lys Gln Ala Ile Gln Ser Lys Tyr 
        195                 200                 205             

Lys Asn Leu His Ile Val Thr Ile Gln Tyr Asp Gln Glu Gln Pro Asp 
    210                 215                 220                 

Val Gly Leu Thr Ala Ala Glu Asn Met Leu Arg Ala Tyr Pro Gln Met 
225                 230                 235                 240 

Lys Ala Ile Ile Ser Pro Asp Ser Val Gly Val Pro Ala Ala Ala Glu 
                245                 250                 255     

Ala Val Glu Lys Leu Gly Leu Lys Gly Lys Val Phe Val Thr Gly Leu 
            260                 265                 270         

Ala Asp Pro Ile Gln Met Lys Gln Tyr Val Asn Asp Gly Thr Val Gln 
        275                 280                 285             

Glu Phe Val Leu Trp Asp Val Pro Lys Leu Gly Ala Leu Thr Met Tyr 
    290                 295                 300                 

Val Ala Arg Ala Val Val Asp Gly Thr Met Pro Val Asn Gly Thr Phe 
305                 310                 315                 320 

Lys Cys Ala Leu Gly Ser Phe Lys Val Gln Asn Arg Val Val Leu Leu 
                325                 330                 335     

Gly Asn Pro Thr Ile Phe Asn Lys Ser Asn Ile Asn Asn Ala Asn Tyr 
            340                 345                 350         

<210>   589
<211>   352
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   589
Met Lys Leu Arg Thr Lys Lys Ala Lys His Lys Ala Leu Gly Gly Leu 
                5                   10                  15      

Ala Ala Ala Ala Leu Val Ala Thr Val Thr Gly Cys Gly Thr Val Ala 
            20                  25                  30          

Thr Thr Ala Ser Thr Pro Asn Ser Asn Ala Gly Ser Ala Ala Ala Ser 
        35                  40                  45              

Ser Ser Lys Pro Ile Lys Val Ala Phe Ile Pro Lys Glu Ile Gly Ile 
    50                  55                  60                  

Pro Tyr Phe Thr Gly Ala Asp Gln Gly Ala Gln Ser Val Ala Pro Lys 
65                  70                  75                  80  

Leu His Ile Gln Leu Thr Tyr Asn Gly Pro Thr Gln Ala Ser Ala Ala 
                85                  90                  95      

Asp Gln Val Ser Met Ile Asn Ser Tyr Val Ala Gln Gly Tyr Asn Val 
            100                 105                 110         

Ile Ala Val Ser Ala Asn Asp Pro Thr Ser Leu Ala Pro Ala Leu Glu 
        115                 120                 125             

Ser Ala Met Arg Arg Gly Val Lys Val Ile Thr Trp Asp Ser Asp Val 
    130                 135                 140                 

Ile Pro Ser Ala Arg Gln Phe Phe Val Asp Gln Ala Thr Ala Gln Gly 
145                 150                 155                 160 

Ile Gly Thr Thr Leu Val Gln Ile Thr Ala Glu His Phe Lys Ser Gln 
                165                 170                 175     

Lys Asn Val Glu Val Gly Ile Leu Ser Ser Thr Pro Thr Asn Pro Asn 
            180                 185                 190         

Gln Asn Ala Trp Ile Ala Val Met Lys Gln Ala Ile Gln Ser Lys Tyr 
        195                 200                 205             

Lys Asn Leu His Ile Val Thr Ile Gln Tyr Asp Gln Glu Gln Pro Asp 
    210                 215                 220                 

Val Gly Leu Thr Ala Ala Glu Asn Met Leu Arg Ala Tyr Pro Gln Met 
225                 230                 235                 240 

Lys Ala Ile Ile Ser Pro Asp Ser Val Gly Val Pro Ala Ala Ala Glu 
                245                 250                 255     

Ala Val Glu Lys Leu Gly Leu Lys Gly Lys Val Phe Ile Thr Gly Leu 
            260                 265                 270         

Ala Asp Pro Ile Gln Met Lys Gln Tyr Val Asn Asp Gly Thr Val Gln 
        275                 280                 285             

Glu Phe Val Leu Trp Asp Val Pro Lys Leu Gly Ala Leu Thr Met Tyr 
    290                 295                 300                 

Val Ala Arg Ala Val Val Asp Gly Thr Met Pro Val Asn Gly Thr Phe 
305                 310                 315                 320 

Lys Cys Ala Leu Gly Ser Phe Lys Val Gln Asn Arg Val Val Leu Leu 
                325                 330                 335     

Gly Asn Pro Thr Ile Phe Asn Lys Ser Asn Ile Asn Asn Ala Asn Tyr 
            340                 345                 350         

<210>   590
<211>   352
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 579

<400>   590
Met Lys Leu Arg Thr Lys Lys Ala Lys His Lys Ala Leu Gly Gly Leu 
                5                   10                  15      

Ala Ala Ala Ala Leu Val Ala Thr Val Thr Gly Cys Gly Thr Val Ala 
            20                  25                  30          

Thr Thr Ala Ser Thr Pro Asn Ser Asn Ala Gly Ser Ala Ala Ala Ser 
        35                  40                  45              

Ser Ser Lys Pro Ile Lys Val Ala Phe Ile Pro Lys Glu Ile Gly Ile 
    50                  55                  60                  

Pro Tyr Phe Thr Gly Ala Asp Gln Gly Ala Gln Ser Val Ala Pro Lys 
65                  70                  75                  80  

Leu His Ile Gln Ile Thr Tyr Asn Gly Pro Thr Gln Ala Ser Ala Ala 
                85                  90                  95      

Asp Gln Val Ser Met Ile Asn Ser Tyr Val Ala Gln Gly Tyr Asn Val 
            100                 105                 110         

Ile Ala Val Ser Ala Asn Asp Pro Thr Ser Leu Ala Pro Ala Leu Glu 
        115                 120                 125             

Ser Ala Met Arg Arg Gly Val Lys Val Ile Thr Trp Asp Ser Asp Val 
    130                 135                 140                 

Ile Pro Ser Ala Arg Gln Phe Phe Val Asp Gln Ala Thr Ala Gln Gly 
145                 150                 155                 160 

Ile Gly Thr Thr Leu Val Gln Ile Thr Ala Glu His Phe Lys Ser Gln 
                165                 170                 175     

Lys Asn Val Glu Val Gly Ile Leu Ser Ser Thr Pro Thr Asn Pro Asn 
            180                 185                 190         

Gln Asn Ala Trp Ile Ala Val Met Lys Gln Ala Ile Gln Ser Lys Tyr 
        195                 200                 205             

Lys Asn Leu His Ile Val Thr Ile Gln Tyr Asp Gln Glu Gln Pro Asp 
    210                 215                 220                 

Val Gly Leu Thr Ala Ala Glu Asn Met Leu Arg Ala Tyr Pro Gln Met 
225                 230                 235                 240 

Lys Ala Ile Ile Ser Pro Asp Ser Val Gly Val Pro Ala Ala Ala Glu 
                245                 250                 255     

Ala Val Glu Lys Leu Gly Leu Lys Gly Lys Val Phe Val Thr Gly Leu 
            260                 265                 270         

Ala Asp Pro Ile Gln Met Lys Gln Tyr Val Asn Asp Gly Thr Val Gln 
        275                 280                 285             

Glu Phe Val Leu Trp Asp Val Pro Lys Leu Gly Ala Leu Thr Met Tyr 
    290                 295                 300                 

Val Ala Arg Ala Val Val Asp Gly Thr Met Pro Val Asn Gly Thr Phe 
305                 310                 315                 320 

Lys Cys Ala Leu Gly Ser Phe Lys Val Gln Asn Arg Val Val Leu Leu 
                325                 330                 335     

Gly Asn Pro Thr Ile Phe Asn Lys Ser Asn Ile Asn Asn Ala Asn Tyr 
            340                 345                 350         

<210>   591
<211>   1059
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   591
atgaagctcc gcacgaaaaa ggcgaaacac aaggctctgg gtggattggc agccgcagcg       60

ctcgtggcca ctgtgacggg gtgtggtact gtcgcgacca ccgcgtccac gcccaattcg      120

aatgccggga gcgcagcagc ctcgtcgtcc aaaccgatca aggttgcctt tatcccgaag      180

gaaatcggca taccgtactt cacaggcgcg gatcaagggg cccaatctgt tgcaccgaag      240

cttcacattc aactcacgta taacgggccg acgaatgcaa gcgcagctga tcaggtttcg      300

atgatcaaca gctacgttgc ccaaggttac aacgtcattg ctgtgtccgc gaatgatccc      360

acttctttgg ccccagcgtt ggaatctgca atgcgcaggg gcgtgaaggt cattacgtgg      420

gactctgatg tcatcccgtc ggcgcgccag ttctttgtcg accaggcgac agcgcaaggc      480

attggcacca ctcttgtaca gatcacggcg gaacatttta agagccagaa gaatgtcgag      540

gttggcattc tgtcgtccac cccgacaaat ccgaatcaga acgcctggat cgcggtcatg      600

aaacaggcga ttcagagcaa gtacaagaac ttgcatatcg taaccattca gtacgatcag      660

gagcaacctg acgtgggatt gacggccgct gaaaacatgt tgcgagccta tccacagatg      720

aaggcgataa tatctccgga ttctgttgga gtccctgctg cagcagaagc cgtcgaaaaa      780

ctgggcctta agggtaaagt gttcgttacc ggactcgcgg atccaattca aatgaagcaa      840

tatgtgaatg acgggactgt ccaggaattc gtgctgtggg acgtgccgaa actgggtgct      900

ctcaccatgt atgtcgctcg ggccgtggta gatggtacaa tgcctgtaaa cggcacgttc      960

aagtgtgcgt tgggttcgtt caaggtgcaa aatagagttg tacttttggg caatccaaca     1020

atatttaaca aatcgaacat caacaatgcg aattactga                            1059


<210>   592
<211>   1059
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   592
atgaagctcc gcacgaaaaa ggcgaaacac aaggctctgg gtggattggc agccgcagcg       60

ctcgtggcca ctgtgacggg gtgtggtact gtcgcgacca ccgcgtccac gcccaattcg      120

aatgccggga gcgcagcagc ctcgtcgtcc aaaccgatca aggttgcctt tatcccgaag      180

gaaatcggca taccgtactt cacaggcgcg gatcaagggg cccaatctgt tgcaccgaag      240

cttcacattc aactcacgta taacgggccg acgcaggcaa gcgcagctga tcaggtttcg      300

atgatccaaa gctacgttgc ccaaggttac aacgtcattg ctgtgtccgc gaatgatccc      360

acttctttgg ccccagcgtt ggaatctgca atgcgcaggg gcgtgaaggt cattacgtgg      420

gactctgatg tcatcccgtc ggcgcgccag ttctttgtcg accaggcgac agcgcaaggc      480

attggcacca ctcttgtaca gatcacggcg gaacatttta agagccagaa gaatgtcgag      540

gttggcattc tgtcgtccac cccgacaaat ccgaatcaga acgcctggat cgcggtcatg      600

aaacaggcga ttcagagcaa gtacaagaac ttgcatatcg taaccattca gtacgatcag      660

gagcaacctg acgtgggatt gacggccgct gaaaacatgt tgcgagccta tccacagatg      720

aaggcgataa tatctccgga ttctgttgga gtccctgctg cagcagaagc cgtcgaaaaa      780

ctgggcctta agggtaaagt gttcgttacc ggactcgcgg atccaattca aatgaagcaa      840

tatgtgaatg acgggactgt ccaggaattc gtgctgtggg acgtgccgaa actgggtgct      900

ctcaccatgt atgtcgctcg ggccgtggta gatggtacaa tgcctgtaaa cggcacgttc      960

aagtgtgcgt tgggttcgtt caaggtgcaa aatagagttg tacttttggg caatccaaca     1020

atatttaaca aatcgaacat caacaatgcg aattactga                            1059


<210>   593
<211>   1059
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   593
atgaagctcc gcacgaaaaa ggcgaaacac aaggctctgg gtggattggc agccgcagcg       60

ctcgtggcca ctgtgacggg gtgtggtact gtcgcgacca ccgcgtccac gcccaattcg      120

aatgccggga gcgcagcagc ctcgtcgtcc aaaccgatca aggttgcctt tatcccgaag      180

gaaatcggca taccgtactt cacaggcgcg gatcaagggg cccaatctgt tgcaccgaag      240

cttcacattc aactcacgta taacgggccg acgcaggcaa gcgcagctga tcaggtttcg      300

atgatcaaca gctacgttgc ccaaggttac aacgtcattg ctgtgtccgc gaatgatccc      360

acttctttgg ccccagcgtt ggaatctgca atgcgcaggg gcgtgaaggt cattacgtgg      420

gactctgatg tcatcccgtc ggcgcgccag ttctttgtcg accaggcgac agcgcaaggc      480

attggcacca ctcttgtaca gatcacggcg gatcatttta agagccagaa gaatgtcgag      540

gttggcattc tgtcgtccac cccgacaaat ccgaatcaga acgcctggat cgcggtcatg      600

aaacaggcga ttcagagcaa gtacaagaac ttgcatatcg taaccattca gtacgatcag      660

gagcaacctg acgtgggatt gacggccgct gaaaacatgt tgcgagccta tccacagatg      720

aaggcgataa tatctccgga ttctgttgga gtccctgctg cagcagaagc cgtcgaaaaa      780

ctgggcctta agggtaaagt gttcgttacc ggactcgcgg atccaattca aatgaagcaa      840

tatgtgaatg acgggactgt ccaggaattc gtgctgtggg acgtgccgaa actgggtgct      900

ctcaccatgt atgtcgctcg ggccgtggta gatggtacaa tgcctgtaaa cggcacgttc      960

aagtgtgcgt tgggttcgtt caaggtgcaa aatagagttg tacttttggg caatccaaca     1020

atatttaaca aatcgaacat caacaatgcg aattactga                            1059


<210>   594
<211>   1059
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   594
atgaagctcc gcacgaaaaa ggcgaaacac aaggctctgg gtggattggc agccgcagcg       60

ctcgtggcca ctgtgacggg gtgtggtact gtcgcgacca ccgcgtccac gcccaattcg      120

aatgccggga gcgcagcagc ctcgtcgtcc aaaccgatca aggttgcctt tatcccgaag      180

gaaatcggca taccgtactt cacaggcgcg gatcaagggg cccaatctgt tgcaccgaag      240

cttcacattc aactcacgta taacgggccg acgcaggcaa gcgcagctga tcaggtttcg      300

atgatcaaca gctacgttgc ccaaggttac aacgtcattg ctgtgtccgc gaatgatccc      360

acttctttgg ccccagcgtt ggaatctgca atgcgcaggg gcgtgaaggt cattacgtgg      420

gactctgatg tcatcccgtc ggcgcgccag ttctttgtcg accaggcgac agcgcaaggc      480

attggcacca ctcttgtaca gatcacggcg gaacatttta agagccagaa gaatgtcgag      540

gttggcattc tgtcgtccac cccgacaaat ccgaatcaga acgcctggat cgcggtcatg      600

aaacaggcga ttcagagcaa gtacaagaac ttgcatatcg taaccattca gtacgatcag      660

gagcaacctg acgtgggatt gacggccgct gaaaacatgt tgcgagccta tccacagatg      720

aaggcgataa tatctccgga ttctgttgga gtccctgctg cagcagaagc cgtcgaaaaa      780

ctgggcctta agggtaaagt gttcattacc ggactcgcgg atccaattca aatgaagcaa      840

tatgtgaatg acgggactgt ccaggaattc gtgctgtggg acgtgccgaa actgggtgct      900

ctcaccatgt atgtcgctcg ggccgtggta gatggtacaa tgcctgtaaa cggcacgttc      960

aagtgtgcgt tgggttcgtt caaggtgcaa aatagagttg tacttttggg caatccaaca     1020

atatttaaca aatcgaacat caacaatgcg aattactga                            1059


<210>   595
<211>   1059
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 580

<400>   595
atgaagctcc gcacgaaaaa ggcgaaacac aaggctctgg gtggattggc agccgcagcg       60

ctcgtggcca ctgtgacggg gtgtggtact gtcgcgacca ccgcgtccac gcccaattcg      120

aatgccggga gcgcagcagc ctcgtcgtcc aaaccgatca aggttgcctt tatcccgaag      180

gaaatcggca taccgtactt cacaggcgcg gatcaagggg cccaatctgt tgcaccgaag      240

cttcacattc aaattacgta taacgggccg acgcaggcaa gcgcagctga tcaggtttcg      300

atgatcaaca gctacgttgc ccaaggttac aacgtcattg ctgtgtccgc gaatgatccc      360

acttctttgg ccccagcgtt ggaatctgca atgcgcaggg gcgtgaaggt cattacgtgg      420

gactctgatg tcatcccgtc ggcgcgccag ttctttgtcg accaggcgac agcgcaaggc      480

attggcacca ctcttgtaca gatcacggcg gaacatttta agagccagaa gaatgtcgag      540

gttggcattc tgtcgtccac cccgacaaat ccgaatcaga acgcctggat cgcggtcatg      600

aaacaggcga ttcagagcaa gtacaagaac ttgcatatcg taaccattca gtacgatcag      660

gagcaacctg acgtgggatt gacggccgct gaaaacatgt tgcgagccta tccacagatg      720

aaggcgataa tatctccgga ttctgttgga gtccctgctg cagcagaagc cgtcgaaaaa      780

ctgggcctta agggtaaagt gttcgttacc ggactcgcgg atccaattca aatgaagcaa      840

tatgtgaatg acgggactgt ccaggaattc gtgctgtggg acgtgccgaa actgggtgct      900

ctcaccatgt atgtcgctcg ggccgtggta gatggtacaa tgcctgtaaa cggcacgttc      960

aagtgtgcgt tgggttcgtt caaggtgcaa aatagagttg tacttttggg caatccaaca     1020

atatttaaca aatcgaacat caacaatgcg aattactga                            1059


<210>   596
<211>   337
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   596
Met Arg Gly Val Ala Glu Asn Arg Ile Trp Ser Leu Ala Ile Ala Gly 
                5                   10                  15      

Leu Leu Ile Leu Glu Ile Gly Phe Phe Gly Val Leu Ser Pro Asp Phe 
            20                  25                  30          

Val Ser Pro Gln Asn Leu Leu Ala Ser Thr Glu Asn Phe Leu Pro Val 
        35                  40                  45              

Gly Phe Met Ala Leu Ser Met Thr Leu Val Ile Ile Thr Gly Gly Ile 
    50                  55                  60                  

Asp Leu Ser Val Gly Ser Met Met Ser Leu Cys Gly Val Val Met Gly 
65                  70                  75                  80  

Leu Leu Trp Gln His Gly Val Asn Ile Trp Leu Ala Ala Leu Leu Ser 
                85                  90                  95      

Ile Leu Leu Gly Ala Leu Leu Gly Phe Ile Asn Gly Gln Leu Ile Val 
            100                 105                 110         

Arg Thr Gly Ile Gln Pro Leu Ile Ala Thr Leu Ala Thr Leu Phe Ile 
        115                 120                 125             

Tyr Gly Ser Leu Ala Met Val Leu Val Gly Gln Gly Glu Gly Ser Ile 
    130                 135                 140                 

Tyr Gly Phe Pro Gln Ser Tyr Leu Ser Leu Gly Thr Gly Thr Val Leu 
145                 150                 155                 160 

Lys Trp Ile Pro Ile Gln Leu Ile Phe Tyr Gly Val Val Ala Cys Leu 
                165                 170                 175     

Phe Gly Phe Leu Leu Lys Tyr Thr Ser Tyr Gly Arg Gln Val Tyr Phe 
            180                 185                 190         

Val Gly Asn Asn Glu Gly Ala Ala Leu Tyr Ser Gly Leu Gln Val Asn 
        195                 200                 205             

Arg Val Lys Thr Ile Thr Tyr Val Leu Ser Gly Cys Met Ser Gly Val 
    210                 215                 220                 

Ala Ala Val Phe Met Gly Ala Tyr Phe Ala Ser Val Arg Gly Asp Met 
225                 230                 235                 240 

Gly Thr Asn Tyr Glu Leu Ser Val Ile Thr Ser Cys Leu Val Gly Gly 
                245                 250                 255     

Val Asn Val Phe Gly Gly Ser Gly Thr Ile Leu Gly Ala Phe Leu Gly 
            260                 265                 270         

Thr Phe Leu Leu Gly Val Leu Gln Gln Gly Leu Asn Met Leu Asn Val 
        275                 280                 285             

Ser Ser Val Glu Gln Ser Val Val Thr Gly Ala Met Leu Ile Ala Ala 
    290                 295                 300                 

Val Gly Leu Gln Gln Leu Ser Gly Leu Phe Ser Arg Arg Arg Arg Val 
305                 310                 315                 320 

Ser Arg Gln Asp Ser Ser Ser Ala Val Glu Thr Thr Thr Ser Ala Arg 
                325                 330                 335     

Asp 
    

<210>   597
<211>   1014
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   597
gtgagaggtg tggccgagaa cagaatttgg tcactagcta ttgcgggtct gttaatcctc       60

gagattgggt tcttcggtgt gttgagcccg gacttcgtaa gtccgcaaaa tttgctggcc      120

tcaacagaga actttcttcc ggttggtttc atggctctca gtatgacgct ggtcatcatt      180

acaggcggca tcgacctgtc cgttggttcc atgatgagtc tttgtggtgt cgttatggga      240

ctgctgtggc agcacggagt gaatatttgg ttggctgcgc ttttatctat ccttcttggc      300

gcactcctag gattcatcaa cggccaactc attgttcgga cgggcattca accgctcatt      360

gccacgctgg caacgctatt catttacggg tctttagcca tggtgcttgt aggtcaaggt      420

gagggttcta tttatggatt tccacaatcc tacctgagtc tggggaccgg cacggttttg      480

aaatggatcc ccatccagct cattttctac ggagtcgttg cttgtctatt cgggttcctg      540

ctgaaataca cgagctacgg caggcaggtt tacttcgttg gaaacaatga gggagcagcg      600

ctgtactccg gtctccaagt aaaccgcgtc aagacgatta cgtatgtgct gtctggatgc      660

atgtctggcg tagccgcggt gttcatgggt gcatacttcg catcagttcg gggcgacatg      720

ggtaccaatt acgaactttc ggtgatcacg tcgtgcctcg tgggcggagt aaatgtattt      780

ggaggatcag gtaccatttt aggggcgttc cttggaacgt ttctccttgg agttctgcaa      840

caagggctca acatgctcaa tgtctcatcc gtagaacaat ccgtcgtaac gggcgcgatg      900

ctgattgcgg ctgtgggtct gcaacaactg agtggtctat tctcgcgcag gcgtcgtgtc      960

tcacgtcagg acagctcgtc ggcggttgag acaacaacca gtgcgcgaga ttag           1014


<210>   598
<211>   284
<212>   PRT
<213>   Fulvimarina pelagi HTCC2506

<400>   598
Ser Asp Arg Phe Leu Thr Thr Ala Asn Leu Leu Asn Gln Ala Arg Leu 
                5                   10                  15      

Met Thr Glu Val Gly Leu Ile Ala Ile Pro Met Thr Phe Val Ile Val 
            20                  25                  30          

Thr Gly Gly Ile Asp Leu Ser Val Gly Ser Ile Met Gly Leu Cys Ala 
        35                  40                  45              

Ile Leu Val Gly Val Phe Trp Gln Asn Ala Gly Leu Pro Leu Pro Ala 
    50                  55                  60                  

Ala Val Gly Leu Ser Leu Val Ala Gly Thr Ala Ala Gly Leu Ala Asn 
65                  70                  75                  80  

Gly Ile Ile Ile Thr Arg Phe Arg Val Pro Pro Leu Ile Ala Thr Leu 
                85                  90                  95      

Ala Thr Leu Ala Leu Tyr Arg Gly Leu Ala Glu Gly Ile Ser Gln Ala 
            100                 105                 110         

Arg Ser Val Arg Gly Tyr Pro Glu Trp Phe Ala Gln Leu Gly Gln Gly 
        115                 120                 125             

Gln Ile Leu Gly Ile Pro Thr Gln Leu Trp Leu Phe Ala Leu Val Ala 
    130                 135                 140                 

Ile Ala Gly Ile Phe Ile Leu Arg Phe Thr Thr Phe Gly Arg Thr Thr 
145                 150                 155                 160 

Tyr Ala Ile Gly Asn Asn Glu Ala Ala Ala Glu Phe Ser Gly Leu Pro 
                165                 170                 175     

Val Glu Arg Thr Lys Leu Leu Ile Tyr Thr Ala Ser Gly Phe Ile Ser 
            180                 185                 190         

Ala Leu Ala Ala Ile Val Phe Val Ser Arg Val Ser Thr Thr Arg Ser 
        195                 200                 205             

Asp Met Gly Asn Gly Ile Glu Leu Glu Val Ile Thr Ala Val Val Leu 
    210                 215                 220                 

Gly Gly Thr Ser Ile Phe Gly Gly Arg Gly Met Val Ile Gly Thr Leu 
225                 230                 235                 240 

Ile Gly Leu Cys Leu Met Gln Ile Leu Gln Asn Gly Leu Ser Leu Ala 
                245                 250                 255     

Gly Val Arg Gly Asp Gly Thr Thr Val Val Ile Gly Ala Ile Leu Ile 
            260                 265                 270         

Val Ala Val Leu Ile Ser Asn Ile Leu Gly Arg Phe 
        275                 280                 

<210>   599
<211>   278
<212>   PRT
<213>   Bacillus anthracis str. A0442

<400>   599
Asp Phe Leu Asn Ile Ser Asn Leu Leu Phe Ser Thr Asn Asp Phe Leu 
                5                   10                  15      

Phe Ile Ala Ile Ala Ala Ile Pro Met Thr Phe Val Ile Val Thr Gly 
            20                  25                  30          

Gly Ile Asp Val Ser Val Gly Ser Ile Met Gly Leu Thr Ser Ile Leu 
        35                  40                  45              

Ile Gly Val Leu Trp Met Asn Gly Ile Ser Ile Leu Phe Ala Val Ile 
    50                  55                  60                  

Ile Ser Leu Ile Ile Ser Cys Leu Ala Gly Ala Leu Asn Gly Phe Ile 
65                  70                  75                  80  

Ile Lys Met Thr Asp Val Glu Pro Leu Val Val Thr Leu Gly Thr Met 
                85                  90                  95      

Phe Leu Tyr Gly Gly Ile Ala Leu Val Ile Ser Gly Gly Ala Gly Gly 
            100                 105                 110         

Ser Gly Tyr Glu Gly Ile Ser Gly Leu Pro Asp Ala Phe Val Gln Leu 
        115                 120                 125             

Ala Ser Gly Ser Phe Ile Gly Ile Pro Asn Leu Leu Trp Leu Leu Ile 
    130                 135                 140                 

Val Leu Thr Val Leu Cys Ala Val Leu Phe His Arg Thr Ile Tyr Gly 
145                 150                 155                 160 

Arg His Val Lys Leu Thr Gly Ala Asn Glu Asn Ala Ala Lys Tyr Thr 
                165                 170                 175     

Gly Ile Met Thr Lys Lys Val Val Ile Ile Ala Tyr Met Leu Ser Gly 
            180                 185                 190         

Leu Gly Gly Gly Leu Gly Gly Thr Phe Leu Thr Ala Tyr Phe Gly Ser 
        195                 200                 205             

Ala Arg Ala Asp Met Gly Ser Glu Thr Ile Leu Pro Ile Ile Thr Ala 
    210                 215                 220                 

Val Val Leu Gly Gly Thr Leu Ile Thr Gly Gly Lys Gly Ser Ile Ile 
225                 230                 235                 240 

Gly Thr Val Leu Ala Ser Ile Phe Ile Gly Leu Met Gln Tyr Gly Leu 
                245                 250                 255     

Gln Met Thr Gly Leu Thr Asn Glu Gln Ser Asn Val Val Ile Gly Ile 
            260                 265                 270         

Ile Leu Ile Leu Ser Val 
        275             

<210>   600
<211>   278
<212>   PRT
<213>   Bacillus thuringiensis serovar konkukian str. 97-27

<400>   600
Asp Phe Leu Asn Ile Ser Asn Leu Leu Phe Ser Thr Asn Asp Phe Leu 
                5                   10                  15      

Phe Ile Ala Ile Ala Ala Ile Pro Met Thr Phe Val Ile Val Thr Gly 
            20                  25                  30          

Gly Ile Asp Val Ser Val Gly Ser Ile Met Gly Leu Thr Ser Ile Leu 
        35                  40                  45              

Ile Gly Val Leu Trp Met Asn Gly Ile Ser Ile Leu Phe Ala Val Ile 
    50                  55                  60                  

Ile Ser Leu Ile Ile Ser Cys Leu Ala Gly Ala Leu Asn Gly Leu Ile 
65                  70                  75                  80  

Ile Lys Met Thr Asp Val Glu Pro Leu Val Val Thr Leu Gly Thr Met 
                85                  90                  95      

Phe Leu Tyr Gly Gly Ile Ala Leu Val Ile Ser Gly Gly Ala Gly Ala 
            100                 105                 110         

Ser Gly Tyr Glu Gly Ile Ser Gly Leu Pro Asp Ala Phe Val Gln Leu 
        115                 120                 125             

Ala Ser Gly Ser Phe Ile Gly Ile Pro Asn Leu Leu Trp Leu Leu Ile 
    130                 135                 140                 

Val Leu Thr Val Leu Cys Ala Val Leu Phe His Arg Thr Ile Tyr Gly 
145                 150                 155                 160 

Arg His Val Lys Leu Thr Gly Ala Asn Glu Asn Ala Ala Lys Tyr Thr 
                165                 170                 175     

Gly Ile Lys Thr Lys Lys Val Val Ile Ile Ala Tyr Met Leu Ser Gly 
            180                 185                 190         

Leu Gly Gly Gly Leu Gly Gly Thr Phe Leu Thr Ala Tyr Phe Gly Ser 
        195                 200                 205             

Ala Arg Ala Asp Met Gly Ser Glu Thr Ile Leu Pro Ile Ile Thr Ala 
    210                 215                 220                 

Val Val Leu Gly Gly Thr Leu Ile Thr Gly Gly Lys Gly Ser Ile Ile 
225                 230                 235                 240 

Gly Thr Val Leu Ala Ser Ile Phe Ile Gly Leu Met Gln Tyr Gly Leu 
                245                 250                 255     

Gln Met Thr Gly Leu Thr Asn Glu Gln Ser Asn Val Val Ile Gly Ile 
            260                 265                 270         

Ile Leu Ile Leu Ser Val 
        275             

<210>   601
<211>   278
<212>   PRT
<213>   Bacillus cereus AH820

<400>   601
Asp Phe Leu Asn Ile Ser Asn Leu Leu Phe Ser Thr Asn Asp Phe Leu 
                5                   10                  15      

Phe Ile Ala Ile Ala Ala Ile Pro Met Thr Phe Val Ile Val Thr Gly 
            20                  25                  30          

Gly Ile Asp Val Ser Val Gly Ser Ile Met Gly Leu Thr Ser Ile Leu 
        35                  40                  45              

Ile Gly Val Leu Trp Met Asn Gly Ile Ser Ile Leu Phe Ala Val Ile 
    50                  55                  60                  

Ile Ser Leu Ile Ile Ser Cys Leu Ala Gly Ala Leu Asn Gly Phe Ile 
65                  70                  75                  80  

Ile Lys Met Thr Asp Val Glu Pro Leu Val Val Thr Leu Gly Thr Met 
                85                  90                  95      

Phe Leu Tyr Gly Gly Ile Ala Leu Val Ile Ser Gly Gly Ala Gly Ala 
            100                 105                 110         

Ser Gly Tyr Glu Gly Ile Ser Gly Leu Pro Asp Ala Phe Val Gln Leu 
        115                 120                 125             

Ala Ser Gly Ser Phe Ile Gly Ile Pro Asn Leu Leu Trp Leu Leu Ile 
    130                 135                 140                 

Val Leu Thr Val Leu Cys Ala Val Leu Phe His Arg Thr Ile Tyr Gly 
145                 150                 155                 160 

Arg His Val Lys Leu Thr Gly Ala Asn Glu Asn Ala Ala Lys Tyr Thr 
                165                 170                 175     

Gly Ile Lys Thr Lys Lys Val Val Ile Ile Ala Tyr Met Leu Ser Gly 
            180                 185                 190         

Leu Gly Gly Gly Leu Gly Gly Thr Phe Leu Thr Ala Tyr Phe Gly Ser 
        195                 200                 205             

Ala Arg Ala Asp Met Gly Ser Glu Thr Ile Leu Pro Ile Ile Thr Ala 
    210                 215                 220                 

Val Val Leu Gly Gly Thr Leu Ile Thr Gly Gly Lys Gly Ser Ile Ile 
225                 230                 235                 240 

Gly Thr Val Leu Ala Ser Ile Phe Ile Gly Leu Met Gln Tyr Gly Leu 
                245                 250                 255     

Gln Met Thr Gly Leu Thr Asn Glu Gln Ser Asn Val Val Ile Gly Ile 
            260                 265                 270         

Ile Leu Ile Leu Ser Val 
        275             

<210>   602
<211>   278
<212>   PRT
<213>   Bacillus anthracis str. Sterne

<400>   602
Asp Phe Leu Asn Ile Ser Asn Leu Leu Phe Ser Thr Asn Asp Phe Leu 
                5                   10                  15      

Phe Ile Ala Ile Ala Ala Ile Pro Met Thr Phe Val Ile Val Thr Gly 
            20                  25                  30          

Gly Ile Asp Val Ser Val Gly Ser Ile Met Gly Leu Thr Ser Ile Leu 
        35                  40                  45              

Ile Gly Val Leu Trp Met Asn Gly Ile Ser Ile Leu Phe Ala Val Ile 
    50                  55                  60                  

Ile Ser Leu Ile Ile Ser Cys Leu Ala Gly Ala Leu Asn Gly Phe Ile 
65                  70                  75                  80  

Ile Lys Met Thr Asp Val Glu Pro Leu Val Val Thr Leu Gly Thr Met 
                85                  90                  95      

Phe Leu Tyr Gly Gly Ile Ala Leu Val Ile Ser Gly Gly Ala Gly Ala 
            100                 105                 110         

Ser Gly Tyr Glu Gly Ile Ser Gly Leu Pro Asp Ala Phe Val Gln Leu 
        115                 120                 125             

Ala Ser Gly Ser Phe Ile Gly Ile Pro Asn Leu Leu Trp Leu Leu Ile 
    130                 135                 140                 

Val Leu Thr Val Leu Cys Ala Val Leu Phe His Arg Thr Ile Tyr Gly 
145                 150                 155                 160 

Arg His Val Lys Leu Thr Gly Ala Asn Glu Asn Ala Ala Lys Tyr Thr 
                165                 170                 175     

Gly Ile Met Thr Lys Lys Val Val Ile Ile Ala Tyr Met Leu Ser Gly 
            180                 185                 190         

Leu Gly Gly Gly Leu Gly Gly Thr Phe Leu Thr Ala Tyr Phe Gly Ser 
        195                 200                 205             

Ala Arg Ala Asp Met Gly Ser Glu Thr Ile Leu Pro Ile Ile Thr Ala 
    210                 215                 220                 

Val Val Leu Gly Gly Thr Leu Ile Thr Gly Gly Lys Gly Ser Ile Ile 
225                 230                 235                 240 

Gly Thr Val Leu Ala Ser Ile Phe Ile Gly Leu Met Gln Tyr Gly Leu 
                245                 250                 255     

Gln Met Thr Gly Leu Thr Asn Glu Gln Ser Asn Val Val Ile Gly Ile 
            260                 265                 270         

Ile Leu Ile Leu Ser Val 
        275             

<210>   603
<211>   337
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   603
Met Arg Gly Val Ala Glu Asn Arg Ile Trp Ser Leu Ala Ile Ala Gly 
                5                   10                  15      

Leu Leu Ile Leu Glu Ile Gly Phe Phe Gly Val Leu Ser Pro Asp Phe 
            20                  25                  30          

Val Ser Pro Gln Asn Leu Leu Ala Ser Thr Glu Asn Phe Leu Pro Val 
        35                  40                  45              

Gly Phe Met Ala Leu Ser Met Thr Leu Val Ile Ile Thr Gly Gly Ile 
    50                  55                  60                  

Asp Leu Ser Val Gly Ser Met Met Ser Leu Cys Gly Val Val Met Gly 
65                  70                  75                  80  

Leu Leu Trp Gln His Gly Val Asn Ile Trp Leu Ala Ala Leu Leu Ser 
                85                  90                  95      

Ile Leu Leu Gly Ala Leu Leu Gly Phe Ile Asn Gly Gln Leu Ile Val 
            100                 105                 110         

Arg Thr Gly Ile Gln Pro Leu Ile Ala Thr Leu Ala Thr Leu Phe Ile 
        115                 120                 125             

Tyr Gly Ser Leu Ala Met Val Leu Val Gly Gln Gly Glu Gly Ser Ile 
    130                 135                 140                 

Tyr Gly Phe Pro Gln Ser Tyr Leu Ser Leu Gly Thr Gly Thr Val Leu 
145                 150                 155                 160 

Lys Trp Ile Pro Ile Gln Leu Ile Phe Tyr Gly Val Val Ala Cys Leu 
                165                 170                 175     

Phe Gly Phe Leu Leu Lys Tyr Thr Ser Tyr Gly Arg Gln Val Tyr Phe 
            180                 185                 190         

Val Gly Asn Asn Glu Gly Ala Ala Leu Tyr Ser Gly Leu Gln Val Asn 
        195                 200                 205             

Arg Val Lys Thr Leu Thr Tyr Val Leu Ser Gly Cys Met Ser Gly Val 
    210                 215                 220                 

Ala Ala Val Phe Met Gly Ala Tyr Phe Ala Ser Val Arg Gly Asp Met 
225                 230                 235                 240 

Gly Thr Asn Tyr Glu Leu Ser Val Ile Thr Ser Cys Leu Val Gly Gly 
                245                 250                 255     

Val Asn Val Phe Gly Gly Ser Gly Thr Ile Leu Gly Ala Phe Leu Gly 
            260                 265                 270         

Thr Phe Leu Leu Gly Val Leu Gln Gln Gly Leu Asn Met Leu Asn Val 
        275                 280                 285             

Ser Ser Val Glu Gln Ser Val Val Thr Gly Ala Met Leu Ile Ala Ala 
    290                 295                 300                 

Val Gly Leu Gln Gln Leu Ser Gly Leu Phe Ser Arg Arg Arg Arg Val 
305                 310                 315                 320 

Ser Arg Gln Asp Ser Ser Ser Ala Val Glu Thr Thr Thr Ser Ala Arg 
                325                 330                 335     

Asp 
    

<210>   604
<211>   337
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   604
Met Arg Gly Val Ala Glu Asn Arg Ile Trp Ser Leu Ala Ile Ala Gly 
                5                   10                  15      

Leu Leu Ile Leu Glu Ile Gly Phe Phe Gly Val Leu Ser Pro Asp Phe 
            20                  25                  30          

Val Ser Pro Gln Asn Leu Leu Ala Ser Thr Glu Asn Phe Leu Pro Val 
        35                  40                  45              

Gly Phe Met Ala Leu Ser Met Thr Leu Val Ile Ile Thr Gly Gly Ile 
    50                  55                  60                  

Asp Leu Ser Val Gly Ser Met Met Ser Leu Cys Gly Val Val Met Gly 
65                  70                  75                  80  

Leu Leu Trp Gln His Gly Val Asn Ile Trp Leu Ala Ala Leu Leu Ser 
                85                  90                  95      

Ile Leu Leu Gly Ala Leu Leu Gly Phe Ile Asn Gly Gln Leu Ile Val 
            100                 105                 110         

Arg Thr Gly Ile Gln Pro Leu Ile Ala Thr Leu Ala Thr Leu Phe Ile 
        115                 120                 125             

Tyr Gly Ser Leu Ala Met Val Leu Val Gly Gln Gly Glu Gly Ser Ile 
    130                 135                 140                 

Tyr Gly Phe Pro Gln Ser Tyr Leu Ser Leu Gly Thr Gly Thr Val Leu 
145                 150                 155                 160 

Lys Trp Ile Pro Ile Gln Leu Ile Phe Tyr Gly Val Val Ala Cys Ile 
                165                 170                 175     

Phe Gly Phe Leu Leu Lys Tyr Thr Ser Tyr Gly Arg Gln Val Tyr Phe 
            180                 185                 190         

Val Gly Asn Asn Glu Gly Ala Ala Leu Tyr Ser Gly Leu Gln Val Asn 
        195                 200                 205             

Arg Val Lys Thr Ile Thr Tyr Val Leu Ser Gly Cys Met Ser Gly Val 
    210                 215                 220                 

Ala Ala Val Phe Met Gly Ala Tyr Phe Ala Ser Val Arg Gly Asp Met 
225                 230                 235                 240 

Gly Thr Asn Tyr Glu Leu Ser Val Ile Thr Ser Cys Leu Val Gly Gly 
                245                 250                 255     

Val Asn Val Phe Gly Gly Ser Gly Thr Ile Leu Gly Ala Phe Leu Gly 
            260                 265                 270         

Thr Phe Leu Leu Gly Val Leu Gln Gln Gly Leu Asn Met Leu Asn Val 
        275                 280                 285             

Ser Ser Val Glu Gln Ser Val Val Thr Gly Ala Met Leu Ile Ala Ala 
    290                 295                 300                 

Val Gly Leu Gln Gln Leu Ser Gly Leu Phe Ser Arg Arg Arg Arg Val 
305                 310                 315                 320 

Ser Arg Gln Asp Ser Ser Ser Ala Val Glu Thr Thr Thr Ser Ala Arg 
                325                 330                 335     

Asp 
    

<210>   605
<211>   337
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   605
Met Arg Gly Val Ala Glu Asn Arg Ile Trp Ser Leu Ala Ile Ala Gly 
                5                   10                  15      

Leu Leu Ile Leu Glu Ile Gly Phe Phe Gly Val Leu Ser Pro Asp Phe 
            20                  25                  30          

Val Ser Pro Gln Asn Leu Leu Ala Ser Thr Glu Asn Phe Leu Pro Val 
        35                  40                  45              

Gly Phe Met Ala Leu Ser Met Thr Leu Val Ile Ile Thr Gly Gly Ile 
    50                  55                  60                  

Asp Leu Ser Val Gly Ser Met Met Ser Leu Cys Gly Val Val Met Gly 
65                  70                  75                  80  

Leu Leu Trp Gln His Gly Val Asn Ile Trp Leu Ala Ala Leu Leu Ser 
                85                  90                  95      

Ile Leu Leu Gly Ala Leu Leu Gly Phe Ile Asn Gly Gln Leu Ile Val 
            100                 105                 110         

Arg Thr Gly Ile Gln Pro Leu Ile Ala Thr Leu Ala Thr Leu Phe Ile 
        115                 120                 125             

Tyr Gly Ser Leu Ala Met Val Leu Val Gly Gln Gly Glu Gly Ser Ile 
    130                 135                 140                 

Tyr Gly Phe Pro Gln Ser Tyr Leu Ser Leu Gly Thr Gly Thr Val Leu 
145                 150                 155                 160 

Lys Trp Ile Pro Ile Gln Leu Ile Phe Tyr Gly Val Val Ala Cys Leu 
                165                 170                 175     

Phe Gly Phe Leu Leu Lys Tyr Thr Ser Tyr Gly Arg Gln Val Tyr Phe 
            180                 185                 190         

Val Gly Asn Asn Glu Gly Ala Ala Leu Tyr Ser Gly Leu Gln Val Asn 
        195                 200                 205             

Arg Val Lys Thr Ile Thr Tyr Val Leu Ser Gly Cys Met Ser Gly Val 
    210                 215                 220                 

Ala Ala Val Phe Met Gly Ala Tyr Phe Ala Ser Val Arg Gly Asp Met 
225                 230                 235                 240 

Gly Thr Asn Tyr Glu Leu Ser Val Ile Thr Ser Cys Leu Val Gly Gly 
                245                 250                 255     

Val Asn Val Phe Gly Gly Ser Gly Thr Ile Ile Gly Ala Phe Leu Gly 
            260                 265                 270         

Thr Phe Leu Leu Gly Val Leu Gln Gln Gly Leu Asn Met Leu Asn Val 
        275                 280                 285             

Ser Ser Val Glu Gln Ser Val Val Thr Gly Ala Met Leu Ile Ala Ala 
    290                 295                 300                 

Val Gly Leu Gln Gln Leu Ser Gly Leu Phe Ser Arg Arg Arg Arg Val 
305                 310                 315                 320 

Ser Arg Gln Asp Ser Ser Ser Ala Val Glu Thr Thr Thr Ser Ala Arg 
                325                 330                 335     

Asp 
    

<210>   606
<211>   337
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   606
Met Arg Gly Val Ala Glu Asn Arg Ile Trp Ser Leu Ala Ile Ala Gly 
                5                   10                  15      

Leu Leu Ile Ile Glu Ile Gly Phe Phe Gly Val Leu Ser Pro Asp Phe 
            20                  25                  30          

Val Ser Pro Gln Asn Leu Leu Ala Ser Thr Glu Asn Phe Leu Pro Val 
        35                  40                  45              

Gly Phe Met Ala Leu Ser Met Thr Leu Val Ile Ile Thr Gly Gly Ile 
    50                  55                  60                  

Asp Leu Ser Val Gly Ser Met Met Ser Leu Cys Gly Val Val Met Gly 
65                  70                  75                  80  

Leu Leu Trp Gln His Gly Val Asn Ile Trp Leu Ala Ala Leu Leu Ser 
                85                  90                  95      

Ile Leu Leu Gly Ala Leu Leu Gly Phe Ile Asn Gly Gln Leu Ile Val 
            100                 105                 110         

Arg Thr Gly Ile Gln Pro Leu Ile Ala Thr Leu Ala Thr Leu Phe Ile 
        115                 120                 125             

Tyr Gly Ser Leu Ala Met Val Leu Val Gly Gln Gly Glu Gly Ser Ile 
    130                 135                 140                 

Tyr Gly Phe Pro Gln Ser Tyr Leu Ser Leu Gly Thr Gly Thr Val Leu 
145                 150                 155                 160 

Lys Trp Ile Pro Ile Gln Leu Ile Phe Tyr Gly Val Val Ala Cys Leu 
                165                 170                 175     

Phe Gly Phe Leu Leu Lys Tyr Thr Ser Tyr Gly Arg Gln Val Tyr Phe 
            180                 185                 190         

Val Gly Asn Asn Glu Gly Ala Ala Leu Tyr Ser Gly Leu Gln Val Asn 
        195                 200                 205             

Arg Val Lys Thr Ile Thr Tyr Val Leu Ser Gly Cys Met Ser Gly Val 
    210                 215                 220                 

Ala Ala Val Phe Met Gly Ala Tyr Phe Ala Ser Val Arg Gly Asp Met 
225                 230                 235                 240 

Gly Thr Asn Tyr Glu Leu Ser Val Ile Thr Ser Cys Leu Val Gly Gly 
                245                 250                 255     

Val Asn Val Phe Gly Gly Ser Gly Thr Ile Leu Gly Ala Phe Leu Gly 
            260                 265                 270         

Thr Phe Leu Leu Gly Val Leu Gln Gln Gly Leu Asn Met Leu Asn Val 
        275                 280                 285             

Ser Ser Val Glu Gln Ser Val Val Thr Gly Ala Met Leu Ile Ala Ala 
    290                 295                 300                 

Val Gly Leu Gln Gln Leu Ser Gly Leu Phe Ser Arg Arg Arg Arg Val 
305                 310                 315                 320 

Ser Arg Gln Asp Ser Ser Ser Ala Val Glu Thr Thr Thr Ser Ala Arg 
                325                 330                 335     

Asp 
    

<210>   607
<211>   337
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 596

<400>   607
Met Arg Gly Val Ala Glu Asn Arg Ile Trp Ser Leu Ala Ile Ala Gly 
                5                   10                  15      

Leu Leu Ile Leu Glu Ile Gly Phe Phe Gly Val Leu Ser Pro Asp Phe 
            20                  25                  30          

Val Ser Pro Gln Asn Leu Leu Ala Ser Thr Glu Asn Phe Leu Pro Val 
        35                  40                  45              

Gly Phe Met Ala Leu Ser Met Thr Leu Val Ile Ile Thr Gly Gly Ile 
    50                  55                  60                  

Asp Leu Ser Val Gly Ser Met Met Ser Leu Cys Gly Val Val Met Gly 
65                  70                  75                  80  

Leu Leu Trp Gln His Gly Val Asn Ile Trp Leu Ala Ala Leu Leu Ser 
                85                  90                  95      

Ile Leu Leu Gly Ala Leu Leu Gly Phe Ile Asn Gly Gln Leu Ile Val 
            100                 105                 110         

Lys Thr Gly Ile Gln Pro Leu Ile Ala Thr Leu Ala Thr Leu Phe Ile 
        115                 120                 125             

Tyr Gly Ser Leu Ala Met Val Leu Val Gly Gln Gly Glu Gly Ser Ile 
    130                 135                 140                 

Tyr Gly Phe Pro Gln Ser Tyr Leu Ser Leu Gly Thr Gly Thr Val Leu 
145                 150                 155                 160 

Lys Trp Ile Pro Ile Gln Leu Ile Phe Tyr Gly Val Val Ala Cys Leu 
                165                 170                 175     

Phe Gly Phe Leu Leu Lys Tyr Thr Ser Tyr Gly Arg Gln Val Tyr Phe 
            180                 185                 190         

Val Gly Asn Asn Glu Gly Ala Ala Leu Tyr Ser Gly Leu Gln Val Asn 
        195                 200                 205             

Arg Val Lys Thr Ile Thr Tyr Val Leu Ser Gly Cys Met Ser Gly Val 
    210                 215                 220                 

Ala Ala Val Phe Met Gly Ala Tyr Phe Ala Ser Val Arg Gly Asp Met 
225                 230                 235                 240 

Gly Thr Asn Tyr Glu Leu Ser Val Ile Thr Ser Cys Leu Val Gly Gly 
                245                 250                 255     

Val Asn Val Phe Gly Gly Ser Gly Thr Ile Leu Gly Ala Phe Leu Gly 
            260                 265                 270         

Thr Phe Leu Leu Gly Val Leu Gln Gln Gly Leu Asn Met Leu Asn Val 
        275                 280                 285             

Ser Ser Val Glu Gln Ser Val Val Thr Gly Ala Met Leu Ile Ala Ala 
    290                 295                 300                 

Val Gly Leu Gln Gln Leu Ser Gly Leu Phe Ser Arg Arg Arg Arg Val 
305                 310                 315                 320 

Ser Arg Gln Asp Ser Ser Ser Ala Val Glu Thr Thr Thr Ser Ala Arg 
                325                 330                 335     

Asp 
    

<210>   608
<211>   1014
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   608
gtgagaggtg tggccgagaa cagaatttgg tcactagcta ttgcgggtct gttaatcctc       60

gagattgggt tcttcggtgt gttgagcccg gacttcgtaa gtccgcaaaa tttgctggcc      120

tcaacagaga actttcttcc ggttggtttc atggctctca gtatgacgct ggtcatcatt      180

acaggcggca tcgacctgtc cgttggttcc atgatgagtc tttgtggtgt cgttatggga      240

ctgctgtggc agcacggagt gaatatttgg ttggctgcgc ttttatctat ccttcttggc      300

gcactcctag gattcatcaa cggccaactc attgttcgga cgggcattca accgctcatt      360

gccacgctgg caacgctatt catttacggg tctttagcca tggtgcttgt aggtcaaggt      420

gagggttcta tttatggatt tccacaatcc tacctgagtc tggggaccgg cacggttttg      480

aaatggatcc ccatccagct cattttctac ggagtcgttg cttgtctatt cgggttcctg      540

ctgaaataca cgagctacgg caggcaggtt tacttcgttg gaaacaatga gggagcagcg      600

ctgtactccg gtctccaagt aaaccgcgtc aagacgttaa cgtatgtgct gtctggatgc      660

atgtctggcg tagccgcggt gttcatgggt gcatacttcg catcagttcg gggcgacatg      720

ggtaccaatt acgaactttc ggtgatcacg tcgtgcctcg tgggcggagt aaatgtattt      780

ggaggatcag gtaccatttt aggggcgttc cttggaacgt ttctccttgg agttctgcaa      840

caagggctca acatgctcaa tgtctcatcc gtagaacaat ccgtcgtaac gggcgcgatg      900

ctgattgcgg ctgtgggtct gcaacaactg agtggtctat tctcgcgcag gcgtcgtgtc      960

tcacgtcagg acagctcgtc ggcggttgag acaacaacca gtgcgcgaga ttag           1014


<210>   609
<211>   1014
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   609
gtgagaggtg tggccgagaa cagaatttgg tcactagcta ttgcgggtct gttaatcctc       60

gagattgggt tcttcggtgt gttgagcccg gacttcgtaa gtccgcaaaa tttgctggcc      120

tcaacagaga actttcttcc ggttggtttc atggctctca gtatgacgct ggtcatcatt      180

acaggcggca tcgacctgtc cgttggttcc atgatgagtc tttgtggtgt cgttatggga      240

ctgctgtggc agcacggagt gaatatttgg ttggctgcgc ttttatctat ccttcttggc      300

gcactcctag gattcatcaa cggccaactc attgttcgga cgggcattca accgctcatt      360

gccacgctgg caacgctatt catttacggg tctttagcca tggtgcttgt aggtcaaggt      420

gagggttcta tttatggatt tccacaatcc tacctgagtc tggggaccgg cacggttttg      480

aaatggatcc ccatccagct cattttctac ggagtcgttg cttgtatttt cgggttcctg      540

ctgaaataca cgagctacgg caggcaggtt tacttcgttg gaaacaatga gggagcagcg      600

ctgtactccg gtctccaagt aaaccgcgtc aagacgatta cgtatgtgct gtctggatgc      660

atgtctggcg tagccgcggt gttcatgggt gcatacttcg catcagttcg gggcgacatg      720

ggtaccaatt acgaactttc ggtgatcacg tcgtgcctcg tgggcggagt aaatgtattt      780

ggaggatcag gtaccatttt aggggcgttc cttggaacgt ttctccttgg agttctgcaa      840

caagggctca acatgctcaa tgtctcatcc gtagaacaat ccgtcgtaac gggcgcgatg      900

ctgattgcgg ctgtgggtct gcaacaactg agtggtctat tctcgcgcag gcgtcgtgtc      960

tcacgtcagg acagctcgtc ggcggttgag acaacaacca gtgcgcgaga ttag           1014


<210>   610
<211>   1014
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   610
gtgagaggtg tggccgagaa cagaatttgg tcactagcta ttgcgggtct gttaatcctc       60

gagattgggt tcttcggtgt gttgagcccg gacttcgtaa gtccgcaaaa tttgctggcc      120

tcaacagaga actttcttcc ggttggtttc atggctctca gtatgacgct ggtcatcatt      180

acaggcggca tcgacctgtc cgttggttcc atgatgagtc tttgtggtgt cgttatggga      240

ctgctgtggc agcacggagt gaatatttgg ttggctgcgc ttttatctat ccttcttggc      300

gcactcctag gattcatcaa cggccaactc attgttcgga cgggcattca accgctcatt      360

gccacgctgg caacgctatt catttacggg tctttagcca tggtgcttgt aggtcaaggt      420

gagggttcta tttatggatt tccacaatcc tacctgagtc tggggaccgg cacggttttg      480

aaatggatcc ccatccagct cattttctac ggagtcgttg cttgtctatt cgggttcctg      540

ctgaaataca cgagctacgg caggcaggtt tacttcgttg gaaacaatga gggagcagcg      600

ctgtactccg gtctccaagt aaaccgcgtc aagacgatta cgtatgtgct gtctggatgc      660

atgtctggcg tagccgcggt gttcatgggt gcatacttcg catcagttcg gggcgacatg      720

ggtaccaatt acgaactttc ggtgatcacg tcgtgcctcg tgggcggagt aaatgtattt      780

ggaggatcag gtaccattat tggggcgttc cttggaacgt ttctccttgg agttctgcaa      840

caagggctca acatgctcaa tgtctcatcc gtagaacaat ccgtcgtaac gggcgcgatg      900

ctgattgcgg ctgtgggtct gcaacaactg agtggtctat tctcgcgcag gcgtcgtgtc      960

tcacgtcagg acagctcgtc ggcggttgag acaacaacca gtgcgcgaga ttag           1014


<210>   611
<211>   1014
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   611
gtgagaggtg tggccgagaa cagaatttgg tcactagcta ttgcgggtct gttaatcatt       60

gagattgggt tcttcggtgt gttgagcccg gacttcgtaa gtccgcaaaa tttgctggcc      120

tcaacagaga actttcttcc ggttggtttc atggctctca gtatgacgct ggtcatcatt      180

acaggcggca tcgacctgtc cgttggttcc atgatgagtc tttgtggtgt cgttatggga      240

ctgctgtggc agcacggagt gaatatttgg ttggctgcgc ttttatctat ccttcttggc      300

gcactcctag gattcatcaa cggccaactc attgttcgga cgggcattca accgctcatt      360

gccacgctgg caacgctatt catttacggg tctttagcca tggtgcttgt aggtcaaggt      420

gagggttcta tttatggatt tccacaatcc tacctgagtc tggggaccgg cacggttttg      480

aaatggatcc ccatccagct cattttctac ggagtcgttg cttgtctatt cgggttcctg      540

ctgaaataca cgagctacgg caggcaggtt tacttcgttg gaaacaatga gggagcagcg      600

ctgtactccg gtctccaagt aaaccgcgtc aagacgatta cgtatgtgct gtctggatgc      660

atgtctggcg tagccgcggt gttcatgggt gcatacttcg catcagttcg gggcgacatg      720

ggtaccaatt acgaactttc ggtgatcacg tcgtgcctcg tgggcggagt aaatgtattt      780

ggaggatcag gtaccatttt aggggcgttc cttggaacgt ttctccttgg agttctgcaa      840

caagggctca acatgctcaa tgtctcatcc gtagaacaat ccgtcgtaac gggcgcgatg      900

ctgattgcgg ctgtgggtct gcaacaactg agtggtctat tctcgcgcag gcgtcgtgtc      960

tcacgtcagg acagctcgtc ggcggttgag acaacaacca gtgcgcgaga ttag           1014


<210>   612
<211>   1014
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 597

<400>   612
gtgagaggtg tggccgagaa cagaatttgg tcactagcta ttgcgggtct gttaatcctc       60

gagattgggt tcttcggtgt gttgagcccg gacttcgtaa gtccgcaaaa tttgctggcc      120

tcaacagaga actttcttcc ggttggtttc atggctctca gtatgacgct ggtcatcatt      180

acaggcggca tcgacctgtc cgttggttcc atgatgagtc tttgtggtgt cgttatggga      240

ctgctgtggc agcacggagt gaatatttgg ttggctgcgc ttttatctat ccttcttggc      300

gcactcctag gattcatcaa cggccaactc attgttaaaa cgggcattca accgctcatt      360

gccacgctgg caacgctatt catttacggg tctttagcca tggtgcttgt aggtcaaggt      420

gagggttcta tttatggatt tccacaatcc tacctgagtc tggggaccgg cacggttttg      480

aaatggatcc ccatccagct cattttctac ggagtcgttg cttgtctatt cgggttcctg      540

ctgaaataca cgagctacgg caggcaggtt tacttcgttg gaaacaatga gggagcagcg      600

ctgtactccg gtctccaagt aaaccgcgtc aagacgatta cgtatgtgct gtctggatgc      660

atgtctggcg tagccgcggt gttcatgggt gcatacttcg catcagttcg gggcgacatg      720

ggtaccaatt acgaactttc ggtgatcacg tcgtgcctcg tgggcggagt aaatgtattt      780

ggaggatcag gtaccatttt aggggcgttc cttggaacgt ttctccttgg agttctgcaa      840

caagggctca acatgctcaa tgtctcatcc gtagaacaat ccgtcgtaac gggcgcgatg      900

ctgattgcgg ctgtgggtct gcaacaactg agtggtctat tctcgcgcag gcgtcgtgtc      960

tcacgtcagg acagctcgtc ggcggttgag acaacaacca gtgcgcgaga ttag           1014


<210>   613
<211>   314
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   613
Met Ser Gly Leu Leu Lys Arg Arg Glu Phe Ser Leu Val Val Phe Ile 
                5                   10                  15      

Leu Ile Phe Leu Leu Val Met Leu Phe Val Thr Pro Arg Phe Leu Gln 
            20                  25                  30          

Leu Gly Asn Leu Ile Asn Ile Leu Leu Asn Ile Ser Thr Val Gly Ile 
        35                  40                  45              

Leu Ala Met Gly Gln Cys Leu Val Ile Ile Thr Lys Gly Ile Asp Leu 
    50                  55                  60                  

Ser Val Gly Ala Asn Met Gly Leu Val Thr Leu Val Val Gly Thr Leu 
65                  70                  75                  80  

Leu Leu Asn Gly Val Pro Thr Trp Leu Ser Ile Ala Ile Gly Val Ala 
                85                  90                  95      

Thr Gly Leu Val Cys Gly Gly Leu Asn Ala Val Leu Ile Ser Leu Leu 
            100                 105                 110         

Arg Leu Pro Pro Ile Ile Val Thr Leu Gly Thr Leu Ser Leu Phe Ser 
        115                 120                 125             

Gly Leu Met Tyr Met Val Thr Asn Gly Gln Trp Ile Gln Asn Leu Pro 
    130                 135                 140                 

Ser Ser Phe Leu Ala Ile Gly Asn Ser Lys Val Val Gly Ile Pro Gly 
145                 150                 155                 160 

Pro Val Ile Val Leu Val Ile Val Leu Ile Val Leu Ser Val Phe Met 
                165                 170                 175     

Glu Gln Thr Val Leu Gly Arg Tyr Ile Tyr Ala Val Gly Asn Asn Pro 
            180                 185                 190         

Asn Ala Ala Arg Leu Ala Gly Leu Ser Thr Asn Arg Thr Ile Ile Val 
        195                 200                 205             

Pro Tyr Val Leu Met Gly Leu Leu Ala Gly Ile Ala Gly Val Leu Tyr 
    210                 215                 220                 

Leu Ser Tyr Asn Gly Phe Ser Thr Pro Thr Thr Gly Ala Asp Leu Asn 
225                 230                 235                 240 

Leu Glu Ser Ile Ala Ala Ala Val Ile Gly Gly Thr Asn Val Phe Gly 
                245                 250                 255     

Gly Arg Gly Thr Ala Leu Gly Ser Val Leu Gly Ala Val Leu Leu Gly 
            260                 265                 270         

Val Ile Thr Glu Ala Leu Val Phe Phe His Leu Pro Ala Val Trp Asn 
        275                 280                 285             

Asp Ala Val Glu Gly Leu Ile Ile Leu Ile Ala Val Ile Ala Asp Ser 
    290                 295                 300                 

Gly Leu Arg Arg Ser Gln Arg Val Ala Gly 
305                 310                 

<210>   614
<211>   945
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   614
atgagtggat tactgaaaag gcgcgagttt tcactcgttg tgttcatcct gatttttcta       60

ctcgttatgt tgttcgttac tccgcgtttt cttcaactgg ggaatcttat caatatacta      120

cttaacatat cgacggttgg aattttggca atgggtcagt gcttggtcat catcacgaag      180

gggattgatc tgtcggttgg ggcaaatatg gggcttgtga cgctcgtggt tggcaccctg      240

ttactgaacg gtgtgccgac ctggttgagc atcgcgatcg gtgtggctac ggggcttgtg      300

tgtggcgggc tgaatgcagt gttgattagc cttctaaggc taccacctat catcgtgaca      360

ctaggaactc tcagtttgtt ctcgggtttg atgtacatgg tcaccaatgg gcaatggatt      420

caaaatctac cttcatcatt tcttgccata ggaaattcga aagttgtagg catacctggt      480

ccagtgattg tgcttgtgat cgtcttgatt gtgctgtccg tcttcatgga acaaacagtc      540

cttggtcggt acatctacgc cgttggcaac aacccaaacg ctgctcgtct ggcaggccta      600

tcgacgaatc gtaccatcat cgtcccttac gtcctgatgg gtttgctggc cggcattgca      660

ggggttttgt acctgtcata taacggcttc tctaccccaa ctaccggcgc cgatttaaat      720

ttggagtcta tcgcggcggc cgtgatcggt ggaaccaatg tctttggcgg acgcggtacc      780

gcattggggt cggttctagg tgcggttctg cttggggtga ttaccgaggc actggtgttc      840

tttcatctcc cagcagtctg gaacgacgca gtcgaaggtc tgatcatcct gattgcggtc      900

atcgcggata gcggattgcg gcgttcgcaa agggtagcgg ggtga                      945


<210>   615
<211>   308
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   615
Met Lys His Met Leu Lys Met His Glu Thr Ser Ile Ile Leu Leu Leu 
                5                   10                  15      

Leu Ile Tyr Ile Ala Ile Val Gly Met Ile Asn Pro Ser Phe Ile Gln 
            20                  25                  30          

Phe Asn Ser Leu Ser Leu Leu Met Lys Ser Ser Val Ile Leu Val Val 
        35                  40                  45              

Leu Ala Ile Gly Gln Ser Phe Val Leu Phe Thr Lys Asn Ile Asp Val 
    50                  55                  60                  

Ser Val Gly Ser Ser Met Gly Leu Ser Ala Ala Val Cys Gly Met Met 
65                  70                  75                  80  

Leu Thr Asn Gly Tyr Ser Ala Phe Leu Ser Ile Phe Val Ala Ile Ile 
                85                  90                  95      

Leu Gly Ala Ile Ile Gly Phe Val Asn Gly Ile Gly Val Ala Lys Phe 
            100                 105                 110         

Arg Val Pro Ala Ile Ile Met Thr Leu Gly Met Leu Gly Ile Ile Arg 
        115                 120                 125             

Gly Thr Met Leu Ile Phe Thr Gly Gly Lys Trp Ile Glu Asp Ile Pro 
    130                 135                 140                 

Asn Asp Phe Lys Gln Leu Ser Ser Ile Ile Ile Leu Gly Leu Pro Ile 
145                 150                 155                 160 

Thr Val Trp Phe Val Leu Ile Ile Leu Leu Leu Leu Tyr Phe Phe Leu 
                165                 170                 175     

Arg Lys Val Pro Leu Gly Arg Tyr Phe Tyr Ala Val Gly Asp Asn Glu 
            180                 185                 190         

Asp Gly Ala Arg Leu Ile Gly Ile Pro Val Asn Lys Val Lys Ile Tyr 
        195                 200                 205             

Ala Phe Met Ile Ser Gly Ile Ser Ala Ala Leu Ala Gly Cys Ile Phe 
    210                 215                 220                 

Val Met Asn Ile Gly Phe Val Pro Asn Gln Thr Gly Thr Gly Leu Glu 
225                 230                 235                 240 

Leu Gln Val Ile Ala Ala Ala Val Leu Gly Gly Ile His Leu Lys Gly 
                245                 250                 255     

Gly Thr Gly Ser Leu Phe Gly Ala Ala Leu Gly Ala Leu Phe Leu Glu 
            260                 265                 270         

Thr Ile Ser Ser Ser Leu Val Phe Leu Lys Ile Pro Ala Phe Trp Asn 
        275                 280                 285             

Asn Ala Ile Ser Gly Phe Leu Leu Leu Leu Ile Ile Ile Leu Asp Ser 
    290                 295                 300                 

Val Met Lys Lys 
305             

<210>   616
<211>   282
<212>   PRT
<213>   Delftia acidovorans SPH-1

<400>   616
Pro His Phe Met Thr Trp Gly Asn Trp Ala Asp Ile Leu Arg Gln Thr 
                5                   10                  15      

Ser Ile Asn Gly Ile Leu Ala Ile Gly Met Thr Cys Val Val Leu Thr 
            20                  25                  30          

Ala Gly Ile Asp Leu Ser Val Gly Ala Ile Leu Ala Leu Ala Gly Met 
        35                  40                  45              

Val Gly Ala Trp Leu Ala Ala Asp Gly Gln Gly Leu Ala Val Ser Val 
    50                  55                  60                  

Gly Ala Gly Leu Gly Val Gly Met Leu Leu Gly Gly Val Asn Gly Leu 
65                  70                  75                  80  

Leu Val Ala Trp Phe Ala Val Pro Pro Phe Val Ala Thr Leu Gly Met 
                85                  90                  95      

Leu Ser Ala Ala Arg Gly Leu Thr Tyr Ile Tyr Asn Asp Gly Met Pro 
            100                 105                 110         

Val Ser Glu Leu Pro Asp Gly Phe Leu Ala Ile Gly Ala Gly Gln Leu 
        115                 120                 125             

Gly Pro Val Pro Met Pro Ile Val Ile Phe Ala Val Ala Val Ala Val 
    130                 135                 140                 

Phe Ala Phe Val Leu Arg Tyr Thr Val Tyr Gly Arg Tyr Ile Tyr Ala 
145                 150                 155                 160 

Val Gly Gly Asn Leu Arg Ser Ala Lys Thr Ser Gly Ile Asn Thr Arg 
                165                 170                 175     

Ala Ile Val Leu Leu Val Tyr Val Val Ser Gly Leu Leu Ala Gly Leu 
            180                 185                 190         

Ala Gly Ile Leu Leu Ala Ser Arg Thr Thr Ala Ala Leu Pro Gln Ala 
        195                 200                 205             

Gly Val Ser Tyr Glu Leu Asp Ala Ile Ala Ala Val Val Ile Gly Gly 
    210                 215                 220                 

Thr Ser Leu Ser Gly Gly Thr Gly Ser Leu Gly Gly Thr Val Val Gly 
225                 230                 235                 240 

Ala Leu Leu Ile Gly Val Ile Asn Asn Gly Leu Asn Leu Leu Gly Val 
                245                 250                 255     

Ser Ser Tyr Tyr Gln Gln Leu Ile Lys Gly Val Ile Ile Val Gly Ala 
            260                 265                 270         

Val Leu Leu Asp Ser Ser Arg Arg Arg Ala 
        275                 280         

<210>   617
<211>   308
<212>   PRT
<213>   Bacillus cereus G9241

<400>   617
Met Lys Arg Met Leu Lys Met His Glu Thr Ser Ile Ile Leu Leu Leu 
                5                   10                  15      

Leu Ile Tyr Ile Ala Ile Val Gly Met Ile Asn Pro Ser Phe Ile Gln 
            20                  25                  30          

Phe Asn Ser Leu Ser Leu Leu Ile Lys Ser Ser Val Ile Leu Val Val 
        35                  40                  45              

Leu Ala Ile Gly Gln Ser Phe Val Leu Phe Thr Lys Asn Ile Asp Val 
    50                  55                  60                  

Ser Val Gly Ser Ser Met Gly Leu Ser Ala Ala Val Cys Gly Met Met 
65                  70                  75                  80  

Leu Thr Asn Gly Tyr Ser Ala Phe Leu Ser Ile Phe Ala Ala Ile Ile 
                85                  90                  95      

Leu Gly Ala Ile Ile Gly Phe Val Asn Gly Ile Gly Val Ala Lys Phe 
            100                 105                 110         

Arg Val Pro Ala Ile Ile Met Thr Leu Gly Met Leu Gly Ile Ile Arg 
        115                 120                 125             

Gly Ala Met Leu Ile Phe Thr Gly Gly Lys Trp Ile Glu Asp Ile Pro 
    130                 135                 140                 

Ser His Phe Lys Gln Leu Ser Ser Ile Val Ile Leu Gly Leu Pro Ile 
145                 150                 155                 160 

Thr Val Trp Phe Val Leu Ile Ile Leu Leu Leu Leu Tyr Phe Phe Leu 
                165                 170                 175     

Arg Lys Val Pro Phe Gly Arg Tyr Phe Tyr Ala Val Gly Asp Asn Glu 
            180                 185                 190         

Asp Gly Ala Arg Leu Ile Gly Ile Pro Val Asn Gln Val Lys Ile Tyr 
        195                 200                 205             

Ala Phe Ile Ile Ser Gly Ile Ser Ala Ala Leu Ala Gly Cys Ile Phe 
    210                 215                 220                 

Val Met Asn Ile Gly Phe Val Pro Asn Gln Thr Gly Thr Gly Leu Glu 
225                 230                 235                 240 

Leu Gln Val Ile Ala Ala Ala Val Leu Gly Gly Ile His Leu Lys Gly 
                245                 250                 255     

Gly Thr Gly Ser Ile Phe Gly Ala Ala Leu Gly Ala Leu Phe Leu Glu 
            260                 265                 270         

Thr Ile Ser Ser Ser Leu Val Phe Leu Lys Ile Pro Ala Phe Trp Asn 
        275                 280                 285             

Asn Ala Ile Ser Gly Phe Leu Leu Leu Leu Ile Ile Ile Leu Asp Ser 
    290                 295                 300                 

Val Met Lys Lys 
305             

<210>   618
<211>   309
<212>   PRT
<213>   Enterobacter sp. 638

<400>   618
Met Lys Thr Leu Leu Lys Asn Arg Glu Leu Ser Ala Phe Leu Ala Ile 
                5                   10                  15      

Leu Ala Leu Phe Gly Val Leu Val Ala Leu Asn Pro Ala Tyr Leu Ser 
            20                  25                  30          

Phe Gln Thr Leu Gly Met Ile Phe Ala Ser Ser Gln Ile Leu Ile Leu 
        35                  40                  45              

Leu Ala Leu Gly Ala Ala Leu Val Met Leu Thr Arg Asn Ile Asp Val 
    50                  55                  60                  

Ser Val Gly Ser Thr Val Gly Leu Cys Ala Ile Ala Val Gly Val Ala 
65                  70                  75                  80  

Leu Asn Asn Gly Tyr Ser Leu Pro Val Ser Met Leu Phe Ala Leu Ala 
                85                  90                  95      

Ile Gly Ala Leu Ala Gly Ala Phe Asn Gly Leu Leu Val Val Gly Leu 
            100                 105                 110         

Arg Ile Pro Ala Ile Val Ala Thr Leu Gly Thr Leu Gly Leu Tyr Arg 
        115                 120                 125             

Gly Ala Met Leu Leu Trp Thr Gly Gly Lys Trp Ile Glu Gly Leu Pro 
    130                 135                 140                 

Ser Ser Leu Lys Ser Leu Ser Glu Pro Val Ala Leu Gly Val Ser Pro 
145                 150                 155                 160 

Leu Gly Met Ala Val Leu Phe Leu Val Leu Ile Gly Ala Trp Thr Leu 
                165                 170                 175     

Ser Arg Thr Val Ser Gly Arg Asp Phe Tyr Ala Val Gly Asp Asn Leu 
            180                 185                 190         

Ala Ala Ala Arg Gln Leu Gly Val Ala Val Asn Arg Thr Arg Met Leu 
        195                 200                 205             

Ala Phe Thr Ile Asn Gly Met Leu Ala Ala Cys Ala Gly Ile Val Phe 
    210                 215                 220                 

Ala Ser Gln Ile Gly Phe Val Pro Asn Gln Thr Gly Ser Gly Leu Glu 
225                 230                 235                 240 

Met Lys Ala Ile Ala Ala Cys Val Leu Gly Gly Ile Ser Leu Leu Gly 
                245                 250                 255     

Gly Thr Gly Thr Leu Ile Gly Ala Phe Leu Gly Ala Phe Phe Leu Thr 
            260                 265                 270         

Gln Ile Asp Thr Val Leu Val Leu Phe Arg Leu Pro Ala Trp Trp Asn 
        275                 280                 285             

Asp Phe Ile Ala Gly Leu Val Leu Leu Gly Val Leu Val Leu Asp Gly 
    290                 295                 300                 

Arg Leu Arg Gln Ala 
305                 

<210>   619
<211>   309
<212>   PRT
<213>   Klebsiella pneumoniae subsp. pneumoniae MGH 78578

<400>   619
Met Lys Thr Leu Leu Lys Asn Arg Glu Leu Ser Ala Phe Phe Ala Ile 
                5                   10                  15      

Val Ala Leu Phe Val Val Leu Val Ala Leu Asn Pro Ala Tyr Phe Ile 
            20                  25                  30          

Leu Gln Thr Leu Ala Met Ile Phe Ala Ser Ser Gln Ile Leu Cys Leu 
        35                  40                  45              

Leu Ala Leu Gly Ala Thr Leu Val Met Leu Thr Arg Asn Ile Asp Val 
    50                  55                  60                  

Ser Val Gly Ser Thr Val Gly Leu Cys Ala Ile Ala Val Gly Val Ala 
65                  70                  75                  80  

Leu Asn Tyr Gly Tyr Gly Leu Ala Thr Ala Ile Ala Phe Ala Leu Ala 
                85                  90                  95      

Ile Gly Ala Leu Ala Gly Ala Phe Asn Gly Leu Leu Val Val Gly Leu 
            100                 105                 110         

Arg Ile Pro Ala Ile Val Ala Thr Leu Gly Thr Leu Gly Leu Tyr Arg 
        115                 120                 125             

Gly Val Met Leu Leu Trp Thr Gly Gly Lys Trp Ile Glu Gly Leu Pro 
    130                 135                 140                 

Asp Ser Leu Lys Ser Leu Ser Glu Pro Ala Phe Ile Gly Val Ser Pro 
145                 150                 155                 160 

Leu Gly Trp Leu Val Leu Ala Leu Leu Leu Ala Gly Gly Trp Leu Leu 
                165                 170                 175     

Ser Arg Thr Ala Phe Gly Arg Asp Phe Tyr Ala Val Gly Asp Asn Leu 
            180                 185                 190         

Ala Ala Ala Arg Gln Leu Gly Val Ala Val Asn Arg Thr Arg Met Leu 
        195                 200                 205             

Ala Phe Thr Leu Asn Gly Met Leu Ala Ala Cys Ala Gly Ile Val Phe 
    210                 215                 220                 

Ala Ala Gln Ile Gly Phe Val Pro Asn Gln Thr Gly Ser Gly Leu Glu 
225                 230                 235                 240 

Met Lys Ala Ile Ala Ala Cys Val Leu Gly Gly Ile Ser Leu Leu Gly 
                245                 250                 255     

Gly Thr Gly Thr Leu Leu Gly Ala Phe Leu Gly Ala Phe Phe Leu Thr 
            260                 265                 270         

Gln Ile Asp Thr Val Leu Val Leu Phe Arg Leu Pro Ala Trp Trp Asn 
        275                 280                 285             

Asp Phe Ile Ala Gly Leu Val Leu Leu Gly Val Leu Val Leu Asp Gly 
    290                 295                 300                 

Arg Leu Arg Gln Ala 
305                 

<210>   620
<211>   314
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   620
Met Ser Gly Leu Leu Lys Arg Arg Glu Phe Ser Leu Val Val Phe Ile 
                5                   10                  15      

Leu Ile Phe Leu Leu Val Met Leu Phe Val Thr Pro Arg Phe Leu Gln 
            20                  25                  30          

Ile Gly Asn Leu Ile Asn Ile Leu Leu Asn Ile Ser Thr Val Gly Ile 
        35                  40                  45              

Leu Ala Met Gly Gln Cys Leu Val Ile Ile Thr Lys Gly Ile Asp Leu 
    50                  55                  60                  

Ser Val Gly Ala Asn Met Gly Leu Val Thr Leu Val Val Gly Thr Leu 
65                  70                  75                  80  

Leu Leu Asn Gly Val Pro Thr Trp Leu Ser Ile Ala Ile Gly Val Ala 
                85                  90                  95      

Thr Gly Leu Val Cys Gly Gly Leu Asn Ala Val Leu Ile Ser Leu Leu 
            100                 105                 110         

Arg Leu Pro Pro Ile Ile Val Thr Leu Gly Thr Leu Ser Leu Phe Ser 
        115                 120                 125             

Gly Leu Met Tyr Met Val Thr Asn Gly Gln Trp Ile Gln Asn Leu Pro 
    130                 135                 140                 

Ser Ser Phe Leu Ala Ile Gly Asn Ser Lys Val Val Gly Ile Pro Gly 
145                 150                 155                 160 

Pro Val Ile Val Leu Val Ile Val Leu Ile Val Leu Ser Val Phe Met 
                165                 170                 175     

Glu Gln Thr Val Leu Gly Arg Tyr Ile Tyr Ala Val Gly Asn Asn Pro 
            180                 185                 190         

Asn Ala Ala Arg Leu Ala Gly Leu Ser Thr Asn Arg Thr Ile Ile Val 
        195                 200                 205             

Pro Tyr Val Leu Met Gly Leu Leu Ala Gly Ile Ala Gly Val Leu Tyr 
    210                 215                 220                 

Leu Ser Tyr Asn Gly Phe Ser Thr Pro Thr Thr Gly Ala Asp Leu Asn 
225                 230                 235                 240 

Leu Glu Ser Ile Ala Ala Ala Val Ile Gly Gly Thr Asn Val Phe Gly 
                245                 250                 255     

Gly Arg Gly Thr Ala Leu Gly Ser Val Leu Gly Ala Val Leu Leu Gly 
            260                 265                 270         

Val Ile Thr Glu Ala Leu Val Phe Phe His Leu Pro Ala Val Trp Asn 
        275                 280                 285             

Asp Ala Val Glu Gly Leu Ile Ile Leu Ile Ala Val Ile Ala Asp Ser 
    290                 295                 300                 

Gly Leu Arg Arg Ser Gln Arg Val Ala Gly 
305                 310                 

<210>   621
<211>   314
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   621
Met Ser Gly Leu Leu Lys Arg Arg Glu Phe Ser Leu Val Val Phe Ile 
                5                   10                  15      

Leu Ile Phe Leu Leu Val Met Leu Phe Val Thr Pro Arg Phe Leu Gln 
            20                  25                  30          

Leu Gly Asn Leu Ile Asn Ile Leu Leu Asn Ile Ser Thr Val Gly Ile 
        35                  40                  45              

Leu Ala Met Gly Gln Cys Leu Val Ile Ile Thr Lys Gly Ile Asp Leu 
    50                  55                  60                  

Ser Val Gly Ala Asn Met Gly Leu Val Thr Leu Val Val Gly Thr Leu 
65                  70                  75                  80  

Leu Leu Asn Gly Val Pro Thr Trp Leu Ser Ile Ala Ile Gly Val Ala 
                85                  90                  95      

Thr Gly Leu Val Cys Gly Gly Leu Asn Ala Val Leu Ile Ser Leu Leu 
            100                 105                 110         

Arg Leu Pro Pro Ile Ile Val Thr Leu Gly Thr Leu Ser Leu Phe Ser 
        115                 120                 125             

Gly Leu Met Tyr Met Val Thr Asn Gly Gln Trp Ile Gln Asn Leu Pro 
    130                 135                 140                 

Ser Ser Phe Leu Ala Ile Gly Asn Ser Lys Val Val Gly Ile Pro Gly 
145                 150                 155                 160 

Pro Val Ile Val Leu Val Ile Val Leu Ile Val Leu Ser Val Phe Met 
                165                 170                 175     

Glu Gln Thr Val Leu Gly Arg Tyr Leu Tyr Ala Val Gly Asn Asn Pro 
            180                 185                 190         

Asn Ala Ala Arg Leu Ala Gly Leu Ser Thr Asn Arg Thr Ile Ile Val 
        195                 200                 205             

Pro Tyr Val Leu Met Gly Leu Leu Ala Gly Ile Ala Gly Val Leu Tyr 
    210                 215                 220                 

Leu Ser Tyr Asn Gly Phe Ser Thr Pro Thr Thr Gly Ala Asp Leu Asn 
225                 230                 235                 240 

Leu Glu Ser Ile Ala Ala Ala Val Ile Gly Gly Thr Asn Val Phe Gly 
                245                 250                 255     

Gly Arg Gly Thr Ala Leu Gly Ser Val Leu Gly Ala Val Leu Leu Gly 
            260                 265                 270         

Val Ile Thr Glu Ala Leu Val Phe Phe His Leu Pro Ala Val Trp Asn 
        275                 280                 285             

Asp Ala Val Glu Gly Leu Ile Ile Leu Ile Ala Val Ile Ala Asp Ser 
    290                 295                 300                 

Gly Leu Arg Arg Ser Gln Arg Val Ala Gly 
305                 310                 

<210>   622
<211>   314
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   622
Met Ser Gly Leu Leu Lys Arg Arg Glu Phe Ser Leu Val Val Phe Ile 
                5                   10                  15      

Leu Ile Phe Leu Leu Val Met Leu Phe Val Thr Pro Arg Phe Leu Gln 
            20                  25                  30          

Leu Gly Asn Leu Ile Asn Ile Leu Leu Asn Ile Ser Thr Val Gly Ile 
        35                  40                  45              

Leu Ala Met Gly Gln Cys Leu Val Ile Ile Thr Lys Gly Ile Asp Leu 
    50                  55                  60                  

Ser Val Gly Ala Asn Met Gly Leu Val Thr Leu Val Val Gly Thr Leu 
65                  70                  75                  80  

Leu Leu Asn Gly Val Pro Thr Trp Leu Ser Ile Ala Ile Gly Val Ala 
                85                  90                  95      

Thr Gly Leu Val Cys Gly Gly Leu Asn Ala Val Leu Ile Ser Leu Leu 
            100                 105                 110         

Arg Leu Pro Pro Ile Ile Val Thr Leu Gly Thr Leu Ser Leu Phe Ser 
        115                 120                 125             

Gly Leu Met Tyr Met Val Thr Asn Gly Gln Trp Ile Gln Asn Leu Pro 
    130                 135                 140                 

Ser Ser Phe Leu Ala Ile Gly Asn Ser Lys Val Ile Gly Ile Pro Gly 
145                 150                 155                 160 

Pro Val Ile Val Leu Val Ile Val Leu Ile Val Leu Ser Val Phe Met 
                165                 170                 175     

Glu Gln Thr Val Leu Gly Arg Tyr Ile Tyr Ala Val Gly Asn Asn Pro 
            180                 185                 190         

Asn Ala Ala Arg Leu Ala Gly Leu Ser Thr Asn Arg Thr Ile Ile Val 
        195                 200                 205             

Pro Tyr Val Leu Met Gly Leu Leu Ala Gly Ile Ala Gly Val Leu Tyr 
    210                 215                 220                 

Leu Ser Tyr Asn Gly Phe Ser Thr Pro Thr Thr Gly Ala Asp Leu Asn 
225                 230                 235                 240 

Leu Glu Ser Ile Ala Ala Ala Val Ile Gly Gly Thr Asn Val Phe Gly 
                245                 250                 255     

Gly Arg Gly Thr Ala Leu Gly Ser Val Leu Gly Ala Val Leu Leu Gly 
            260                 265                 270         

Val Ile Thr Glu Ala Leu Val Phe Phe His Leu Pro Ala Val Trp Asn 
        275                 280                 285             

Asp Ala Val Glu Gly Leu Ile Ile Leu Ile Ala Val Ile Ala Asp Ser 
    290                 295                 300                 

Gly Leu Arg Arg Ser Gln Arg Val Ala Gly 
305                 310                 

<210>   623
<211>   314
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   623
Met Ser Gly Leu Leu Lys Arg Arg Glu Phe Ser Leu Val Val Phe Ile 
                5                   10                  15      

Leu Ile Phe Leu Leu Val Met Leu Phe Val Thr Pro Arg Phe Leu Gln 
            20                  25                  30          

Leu Gly Asn Leu Ile Asn Ile Leu Leu Asn Ile Ser Thr Val Gly Ile 
        35                  40                  45              

Leu Ala Met Gly Gln Cys Leu Val Ile Ile Thr Lys Gly Ile Asp Ile 
    50                  55                  60                  

Ser Val Gly Ala Asn Met Gly Leu Val Thr Leu Val Val Gly Thr Leu 
65                  70                  75                  80  

Leu Leu Asn Gly Val Pro Thr Trp Leu Ser Ile Ala Ile Gly Val Ala 
                85                  90                  95      

Thr Gly Leu Val Cys Gly Gly Leu Asn Ala Val Leu Ile Ser Leu Leu 
            100                 105                 110         

Arg Leu Pro Pro Ile Ile Val Thr Leu Gly Thr Leu Ser Leu Phe Ser 
        115                 120                 125             

Gly Leu Met Tyr Met Val Thr Asn Gly Gln Trp Ile Gln Asn Leu Pro 
    130                 135                 140                 

Ser Ser Phe Leu Ala Ile Gly Asn Ser Lys Val Val Gly Ile Pro Gly 
145                 150                 155                 160 

Pro Val Ile Val Leu Val Ile Val Leu Ile Val Leu Ser Val Phe Met 
                165                 170                 175     

Glu Gln Thr Val Leu Gly Arg Tyr Ile Tyr Ala Val Gly Asn Asn Pro 
            180                 185                 190         

Asn Ala Ala Arg Leu Ala Gly Leu Ser Thr Asn Arg Thr Ile Ile Val 
        195                 200                 205             

Pro Tyr Val Leu Met Gly Leu Leu Ala Gly Ile Ala Gly Val Leu Tyr 
    210                 215                 220                 

Leu Ser Tyr Asn Gly Phe Ser Thr Pro Thr Thr Gly Ala Asp Leu Asn 
225                 230                 235                 240 

Leu Glu Ser Ile Ala Ala Ala Val Ile Gly Gly Thr Asn Val Phe Gly 
                245                 250                 255     

Gly Arg Gly Thr Ala Leu Gly Ser Val Leu Gly Ala Val Leu Leu Gly 
            260                 265                 270         

Val Ile Thr Glu Ala Leu Val Phe Phe His Leu Pro Ala Val Trp Asn 
        275                 280                 285             

Asp Ala Val Glu Gly Leu Ile Ile Leu Ile Ala Val Ile Ala Asp Ser 
    290                 295                 300                 

Gly Leu Arg Arg Ser Gln Arg Val Ala Gly 
305                 310                 

<210>   624
<211>   314
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 613

<400>   624
Met Ser Gly Leu Leu Lys Arg Arg Glu Phe Ser Leu Val Val Phe Ile 
                5                   10                  15      

Leu Ile Phe Leu Leu Val Met Leu Phe Val Thr Pro Arg Phe Leu Gln 
            20                  25                  30          

Leu Gly Asn Leu Ile Asn Ile Leu Leu Asn Ile Ser Thr Val Gly Ile 
        35                  40                  45              

Leu Ala Met Gly Gln Cys Leu Val Ile Ile Thr Lys Gly Ile Asp Leu 
    50                  55                  60                  

Ser Val Gly Ala Asn Met Gly Leu Val Thr Leu Val Val Gly Thr Leu 
65                  70                  75                  80  

Leu Leu Asn Gly Val Pro Thr Trp Leu Ser Ile Ala Ile Gly Val Ala 
                85                  90                  95      

Thr Gly Leu Val Cys Gly Gly Leu Asn Ala Val Leu Ile Ser Leu Leu 
            100                 105                 110         

Arg Leu Pro Pro Ile Ile Val Thr Leu Gly Thr Leu Ser Leu Phe Ser 
        115                 120                 125             

Gly Leu Met Tyr Met Val Thr Asn Gly Gln Trp Ile Gln Asn Leu Pro 
    130                 135                 140                 

Ser Ser Phe Leu Ala Ile Gly Asn Ser Lys Val Val Gly Ile Pro Gly 
145                 150                 155                 160 

Pro Val Ile Val Leu Val Ile Val Leu Ile Val Leu Ser Val Phe Met 
                165                 170                 175     

Glu Gln Thr Val Leu Gly Arg Tyr Ile Tyr Ala Val Gly Asn Asn Pro 
            180                 185                 190         

Asn Ala Ala Arg Leu Ala Gly Leu Ser Thr Gln Arg Thr Ile Ile Val 
        195                 200                 205             

Pro Tyr Val Leu Met Gly Leu Leu Ala Gly Ile Ala Gly Val Leu Tyr 
    210                 215                 220                 

Leu Ser Tyr Asn Gly Phe Ser Thr Pro Thr Thr Gly Ala Asp Leu Asn 
225                 230                 235                 240 

Leu Glu Ser Ile Ala Ala Ala Val Ile Gly Gly Thr Asn Val Phe Gly 
                245                 250                 255     

Gly Arg Gly Thr Ala Leu Gly Ser Val Leu Gly Ala Val Leu Leu Gly 
            260                 265                 270         

Val Ile Thr Glu Ala Leu Val Phe Phe His Leu Pro Ala Val Trp Asn 
        275                 280                 285             

Asp Ala Val Glu Gly Leu Ile Ile Leu Ile Ala Val Ile Ala Asp Ser 
    290                 295                 300                 

Gly Leu Arg Arg Ser Gln Arg Val Ala Gly 
305                 310                 

<210>   625
<211>   945
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   625
atgagtggat tactgaaaag gcgcgagttt tcactcgttg tgttcatcct gatttttcta       60

ctcgttatgt tgttcgttac tccgcgtttt cttcaaattg ggaatcttat caatatacta      120

cttaacatat cgacggttgg aattttggca atgggtcagt gcttggtcat catcacgaag      180

gggattgatc tgtcggttgg ggcaaatatg gggcttgtga cgctcgtggt tggcaccctg      240

ttactgaacg gtgtgccgac ctggttgagc atcgcgatcg gtgtggctac ggggcttgtg      300

tgtggcgggc tgaatgcagt gttgattagc cttctaaggc taccacctat catcgtgaca      360

ctaggaactc tcagtttgtt ctcgggtttg atgtacatgg tcaccaatgg gcaatggatt      420

caaaatctac cttcatcatt tcttgccata ggaaattcga aagttgtagg catacctggt      480

ccagtgattg tgcttgtgat cgtcttgatt gtgctgtccg tcttcatgga acaaacagtc      540

cttggtcggt acatctacgc cgttggcaac aacccaaacg ctgctcgtct ggcaggccta      600

tcgacgaatc gtaccatcat cgtcccttac gtcctgatgg gtttgctggc cggcattgca      660

ggggttttgt acctgtcata taacggcttc tctaccccaa ctaccggcgc cgatttaaat      720

ttggagtcta tcgcggcggc cgtgatcggt ggaaccaatg tctttggcgg acgcggtacc      780

gcattggggt cggttctagg tgcggttctg cttggggtga ttaccgaggc actggtgttc      840

tttcatctcc cagcagtctg gaacgacgca gtcgaaggtc tgatcatcct gattgcggtc      900

atcgcggata gcggattgcg gcgttcgcaa agggtagcgg ggtga                      945


<210>   626
<211>   945
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   626
atgagtggat tactgaaaag gcgcgagttt tcactcgttg tgttcatcct gatttttcta       60

ctcgttatgt tgttcgttac tccgcgtttt cttcaactgg ggaatcttat caatatacta      120

cttaacatat cgacggttgg aattttggca atgggtcagt gcttggtcat catcacgaag      180

gggattgatc tgtcggttgg ggcaaatatg gggcttgtga cgctcgtggt tggcaccctg      240

ttactgaacg gtgtgccgac ctggttgagc atcgcgatcg gtgtggctac ggggcttgtg      300

tgtggcgggc tgaatgcagt gttgattagc cttctaaggc taccacctat catcgtgaca      360

ctaggaactc tcagtttgtt ctcgggtttg atgtacatgg tcaccaatgg gcaatggatt      420

caaaatctac cttcatcatt tcttgccata ggaaattcga aagttgtagg catacctggt      480

ccagtgattg tgcttgtgat cgtcttgatt gtgctgtccg tcttcatgga acaaacagtc      540

cttggtcggt acttatacgc cgttggcaac aacccaaacg ctgctcgtct ggcaggccta      600

tcgacgaatc gtaccatcat cgtcccttac gtcctgatgg gtttgctggc cggcattgca      660

ggggttttgt acctgtcata taacggcttc tctaccccaa ctaccggcgc cgatttaaat      720

ttggagtcta tcgcggcggc cgtgatcggt ggaaccaatg tctttggcgg acgcggtacc      780

gcattggggt cggttctagg tgcggttctg cttggggtga ttaccgaggc actggtgttc      840

tttcatctcc cagcagtctg gaacgacgca gtcgaaggtc tgatcatcct gattgcggtc      900

atcgcggata gcggattgcg gcgttcgcaa agggtagcgg ggtga                      945


<210>   627
<211>   945
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   627
atgagtggat tactgaaaag gcgcgagttt tcactcgttg tgttcatcct gatttttcta       60

ctcgttatgt tgttcgttac tccgcgtttt cttcaactgg ggaatcttat caatatacta      120

cttaacatat cgacggttgg aattttggca atgggtcagt gcttggtcat catcacgaag      180

gggattgatc tgtcggttgg ggcaaatatg gggcttgtga cgctcgtggt tggcaccctg      240

ttactgaacg gtgtgccgac ctggttgagc atcgcgatcg gtgtggctac ggggcttgtg      300

tgtggcgggc tgaatgcagt gttgattagc cttctaaggc taccacctat catcgtgaca      360

ctaggaactc tcagtttgtt ctcgggtttg atgtacatgg tcaccaatgg gcaatggatt      420

caaaatctac cttcatcatt tcttgccata ggaaattcga aagttattgg catacctggt      480

ccagtgattg tgcttgtgat cgtcttgatt gtgctgtccg tcttcatgga acaaacagtc      540

cttggtcggt acatctacgc cgttggcaac aacccaaacg ctgctcgtct ggcaggccta      600

tcgacgaatc gtaccatcat cgtcccttac gtcctgatgg gtttgctggc cggcattgca      660

ggggttttgt acctgtcata taacggcttc tctaccccaa ctaccggcgc cgatttaaat      720

ttggagtcta tcgcggcggc cgtgatcggt ggaaccaatg tctttggcgg acgcggtacc      780

gcattggggt cggttctagg tgcggttctg cttggggtga ttaccgaggc actggtgttc      840

tttcatctcc cagcagtctg gaacgacgca gtcgaaggtc tgatcatcct gattgcggtc      900

atcgcggata gcggattgcg gcgttcgcaa agggtagcgg ggtga                      945


<210>   628
<211>   945
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   628
atgagtggat tactgaaaag gcgcgagttt tcactcgttg tgttcatcct gatttttcta       60

ctcgttatgt tgttcgttac tccgcgtttt cttcaactgg ggaatcttat caatatacta      120

cttaacatat cgacggttgg aattttggca atgggtcagt gcttggtcat catcacgaag      180

gggattgata tttcggttgg ggcaaatatg gggcttgtga cgctcgtggt tggcaccctg      240

ttactgaacg gtgtgccgac ctggttgagc atcgcgatcg gtgtggctac ggggcttgtg      300

tgtggcgggc tgaatgcagt gttgattagc cttctaaggc taccacctat catcgtgaca      360

ctaggaactc tcagtttgtt ctcgggtttg atgtacatgg tcaccaatgg gcaatggatt      420

caaaatctac cttcatcatt tcttgccata ggaaattcga aagttgtagg catacctggt      480

ccagtgattg tgcttgtgat cgtcttgatt gtgctgtccg tcttcatgga acaaacagtc      540

cttggtcggt acatctacgc cgttggcaac aacccaaacg ctgctcgtct ggcaggccta      600

tcgacgaatc gtaccatcat cgtcccttac gtcctgatgg gtttgctggc cggcattgca      660

ggggttttgt acctgtcata taacggcttc tctaccccaa ctaccggcgc cgatttaaat      720

ttggagtcta tcgcggcggc cgtgatcggt ggaaccaatg tctttggcgg acgcggtacc      780

gcattggggt cggttctagg tgcggttctg cttggggtga ttaccgaggc actggtgttc      840

tttcatctcc cagcagtctg gaacgacgca gtcgaaggtc tgatcatcct gattgcggtc      900

atcgcggata gcggattgcg gcgttcgcaa agggtagcgg ggtga                      945


<210>   629
<211>   945
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 614

<400>   629
atgagtggat tactgaaaag gcgcgagttt tcactcgttg tgttcatcct gatttttcta       60

ctcgttatgt tgttcgttac tccgcgtttt cttcaactgg ggaatcttat caatatacta      120

cttaacatat cgacggttgg aattttggca atgggtcagt gcttggtcat catcacgaag      180

gggattgatc tgtcggttgg ggcaaatatg gggcttgtga cgctcgtggt tggcaccctg      240

ttactgaacg gtgtgccgac ctggttgagc atcgcgatcg gtgtggctac ggggcttgtg      300

tgtggcgggc tgaatgcagt gttgattagc cttctaaggc taccacctat catcgtgaca      360

ctaggaactc tcagtttgtt ctcgggtttg atgtacatgg tcaccaatgg gcaatggatt      420

caaaatctac cttcatcatt tcttgccata ggaaattcga aagttgtagg catacctggt      480

ccagtgattg tgcttgtgat cgtcttgatt gtgctgtccg tcttcatgga acaaacagtc      540

cttggtcggt acatctacgc cgttggcaac aacccaaacg ctgctcgtct ggcaggccta      600

tcgacgcaac gtaccatcat cgtcccttac gtcctgatgg gtttgctggc cggcattgca      660

ggggttttgt acctgtcata taacggcttc tctaccccaa ctaccggcgc cgatttaaat      720

ttggagtcta tcgcggcggc cgtgatcggt ggaaccaatg tctttggcgg acgcggtacc      780

gcattggggt cggttctagg tgcggttctg cttggggtga ttaccgaggc actggtgttc      840

tttcatctcc cagcagtctg gaacgacgca gtcgaaggtc tgatcatcct gattgcggtc      900

atcgcggata gcggattgcg gcgttcgcaa agggtagcgg ggtga                      945


<210>   630
<211>   446
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   630
Met Arg Ala Lys Lys Ile Arg Tyr Ala Thr Met Ala Ala Ser Val Ala 
                5                   10                  15      

Met Ala Gly Ile Met Ala Ser Gly Cys Gly Thr Ser Thr Ala Ser Arg 
            20                  25                  30          

Thr Gly Thr Ala Pro Thr Gln Gln Glu Ser Ala Ser Thr His Gln Pro 
        35                  40                  45              

Val Thr Ile Thr Val Ala Ser Trp Asn Asp Ala Ala Asp Ser Leu Arg 
    50                  55                  60                  

Ala Glu Ile Pro Gly Phe Glu Lys Lys Tyr Pro Trp Ile Lys Val Asn 
65                  70                  75                  80  

Val Glu Tyr Val Asp Gly Thr Tyr Gln Lys Val Ile Pro Glu Leu Val 
                85                  90                  95      

Ala Gly Asp Ala Pro Asp Ile Ile Gln Val Gln Gln Arg Asp Phe Gln 
            100                 105                 110         

Thr Phe Leu His Lys Phe Pro Gly Asp Phe Val Asp Leu Thr Pro Tyr 
        115                 120                 125             

Met Ser Ser Ile Lys Asn His Ile Ala Pro Val Ala Leu Asp Val Thr 
    130                 135                 140                 

Val Gln Asn Gly His Ile Tyr Ala Ala Pro Trp Asp Leu Gly Pro Ala 
145                 150                 155                 160 

Ala Leu Tyr Tyr Arg Lys Asp Leu Phe Arg Glu Ala Gly Ile Asn Pro 
                165                 170                 175     

Thr Ser Ile Lys Thr Trp Ser Asp Tyr Leu Ala Ala Gly Lys Lys Leu 
            180                 185                 190         

Val Ala His Phe His Gly Lys Val Lys Met Leu Ala Glu Asn Thr Ser 
        195                 200                 205             

Glu Pro Ser Gln Gly Ile Gln Thr Thr Leu Met Ile Leu Val Asn Glu 
    210                 215                 220                 

Leu Gly Gly Ser Tyr Val Asn Gln Asn Gly Asp Ile Asp Phe Leu Asn 
225                 230                 235                 240 

Pro Gln Leu Glu Lys Ala Met Ser Val Ile Gln Gln Trp Gly Lys Ala 
                245                 250                 255     

Gly Ile Val Ala Asp Ala Pro Thr Trp Asn Asp Gly Ile Ala Ala Phe 
            260                 265                 270         

Ala Asn Gly Gln Val Ala Thr Ile Leu Ser Ala Val Trp Tyr Ala Gly 
        275                 280                 285             

Thr Met Met Asn Ser Ala Pro Lys Gln Ser Gly Leu Trp Gly Ile Val 
    290                 295                 300                 

Pro Leu Pro Ala Phe Thr Pro Gly Gly Asn Asn Glu Ala Asp Thr Gly 
305                 310                 315                 320 

Gly Ser Val Leu Ala Ile Thr Lys Asp Ser Lys Asn Val Gln Ala Ala 
                325                 330                 335     

Trp Asp Phe Ile Asn Tyr Cys Leu Tyr Thr Val Pro Gly Glu Asn Val 
            340                 345                 350         

Gln Leu Lys Tyr Gly Leu Phe Pro Ser Trp Glu Ser Tyr Tyr Thr Ala 
        355                 360                 365             

Lys Gly Thr Asp Phe Asp Gln Asn Phe Pro Tyr Phe Gly Met Pro Ile 
    370                 375                 380                 

Tyr Lys Phe Phe Ala Ser Val Ser Lys His Ile Pro Thr Thr Asn Tyr 
385                 390                 395                 400 

Gly Gly Tyr Phe Glu Asp Tyr Ser Gln Pro Leu Ser Gln Ala Tyr Ile 
                405                 410                 415     

Ser Val Phe Lys Gly Ala Asn Ile Glu Gln Ala Leu Gln Thr Ala Glu 
            420                 425                 430         

Thr Asn Ala Ala Arg Ile Ser Gly Gln Pro Ile Ser Asn Gly 
        435                 440                 445     

<210>   631
<211>   1341
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   631
atgcgcgcga agaagattag atatgcgaca atggctgcat ctgtagcgat ggcgggaatc       60

atggcttccg gctgcgggac aagtaccgca tcaaggaccg gcactgcgcc gacccaacag      120

gaaagcgctt cgactcacca gcccgtgacg attacggtgg cctcctggaa cgatgctgca      180

gactccttga gggcagagat cccaggattc gaaaaaaaat acccatggat taaagtgaac      240

gtggaatatg tggatgggac gtatcagaag gtgatcccag aacttgttgc cggagacgca      300

cctgatatca tccaggttca gcaacgagat tttcaaactt tcctccataa gtttccggga      360

gattttgtcg atttgactcc gtacatgagc tcaatcaaaa atcatatagc tcctgtcgcg      420

ctggacgtaa ctgtgcaaaa cggtcatatc tacgctgctc cgtgggatct ggggccggct      480

gcgttgtatt accgaaagga cctgttccgc gaagcgggaa ttaatccaac ttcaattaag      540

acctggtctg attaccttgc tgcgggtaag aagttagtcg cacattttca tggaaaggtt      600

aagatgctag ctgagaacac gtcggagcca agccaaggca ttcagacgac cctcatgatc      660

ttggtcaatg agcttggcgg aagttatgtg aatcagaacg gagatattga tttcttaaac      720

cctcaactcg agaaggccat gagtgtgatt cagcagtggg gtaaggcagg gattgtggcg      780

gatgcaccta cgtggaacga cggtatcgct gcgtttgcca atggacaggt tgccacgatt      840

ctgtcggccg tttggtatgc cggcactatg atgaatagtg cgcccaagca aagtggtttg      900

tggggcattg ttccgcttcc ggcattcacg cctggtggga acaatgaagc tgatacgggt      960

ggctctgttt tggcaattac gaaagacagc aagaatgttc aggcggcctg ggacttcatt     1020

aattactgtt tgtataccgt cccgggagag aatgttcagt tgaaatacgg tctgttccct     1080

tcgtgggagt cgtactatac ggctaagggt actgactttg atcagaattt cccttacttc     1140

ggaatgccga tctataagtt cttcgcatcc gtatcgaagc acattccgac taccaactat     1200

ggtggctatt tcgaggatta ctctcaaccg ctatcacaag cttacatttc ggtatttaag     1260

ggcgcgaata tcgaacaagc gcttcagact gccgaaacga atgccgcacg tatctctggt     1320

caacccattt caaatggata a                                               1341


<210>   632
<211>   431
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   632
Ser Leu Leu Val Leu Thr Leu Ile Leu Ala Ala Cys Gly Ser Asp Ser 
                5                   10                  15      

Thr Ala Thr Thr Thr Ser Asn Thr Gly Ser Thr Asn Pro Ala Glu Val 
            20                  25                  30          

Lys Gly Glu Ile Thr Val Trp Ala Trp Asn Val Ala Ala Lys Ser Leu 
        35                  40                  45              

Glu Ala Thr Val Pro Ser Phe Asn Gln Lys Tyr Pro Asn Val Lys Val 
    50                  55                  60                  

Thr Val Gln Asp Ile Gly Arg Thr Asp Val Tyr Asp Lys Leu Thr Ser 
65                  70                  75                  80  

Gly Leu Gln Ala Gly Gly Ala Gly Leu Pro Asp Val Val Ala Ile Glu 
                85                  90                  95      

Ser Asp Arg Met Asp Val Tyr Thr Ser Thr Phe Pro Asp Gly Leu Ala 
            100                 105                 110         

Asp Leu Thr Ser Arg Ala Ser Lys Tyr Glu Lys Asp Phe Asp Pro Ser 
        115                 120                 125             

Lys Trp Ala Gln Ser Lys Ile Ser Asp Lys Ile Arg Ser Ile Pro Trp 
    130                 135                 140                 

Asp Ser Gly Pro Thr Gly Leu Trp Tyr Arg Val Asp Ile Phe Glu Gln 
145                 150                 155                 160 

Ala Gly Val Asp Pro Lys Ser Ile Glu Thr Trp Ala Asp Leu Ile Ala 
                165                 170                 175     

Ala Gly Glu Lys Ile Leu Ala Ala Thr Asp Gly Lys Thr Lys Leu Leu 
            180                 185                 190         

Pro Val Asp Ile Val Ala Asp Asp Ala Gly Phe Arg Met Met Thr Ser 
        195                 200                 205             

Gln Leu Gly Val Cys Cys Tyr Phe Asn Asn Asp Gly Lys Ile Asn Leu 
    210                 215                 220                 

Thr Asn Asp Lys Ser Val Gln Ala Leu Thr Leu Leu Lys Glu Ile Asn 
225                 230                 235                 240 

Asp Lys Gly Leu Val Ala Asn Ile Asn Gly Trp Asp Gly Thr Val Ala 
                245                 250                 255     

Ala Thr Lys Asn Gly Asp Val Ala Thr Val Pro Phe Gly Val Trp Tyr 
            260                 265                 270         

Ser Gly Thr Ile Ile Asp Gln Ala Pro Asp Leu Ser Gly Lys Trp Asp 
        275                 280                 285             

Val Met Leu Leu Pro Ala Phe Glu Lys Gly Gly Asn Arg Ala Ala Asn 
    290                 295                 300                 

Leu Gly Gly Ser Thr Leu Ala Ile Pro Ala Ala Thr Lys Asn Leu Asp 
305                 310                 315                 320 

Ala Ala Trp Leu Phe Val Glu His Ala Leu Ala Thr Ser Glu Gly Gln 
                325                 330                 335     

Asn Ile Met Met Glu Lys Phe Gly Ile Trp Pro Ser Tyr Gln Pro Ala 
            340                 345                 350         

Tyr Ser Ala Asp Leu Tyr Ser Lys Pro Val Ala Phe Phe Asn Asn Gln 
        355                 360                 365             

Pro Ile Trp Lys Leu Phe Ala Asp Glu Ile Lys Asn Ile Pro Pro Ala 
    370                 375                 380                 

Thr Tyr Thr Lys Asp Tyr Ala Lys Gly Gln Ala Val Leu Ala Ser Ala 
385                 390                 395                 400 

Gln Ala Lys Val Leu Ser Gln Gly Met Asp Pro Lys Gln Ala Leu Gln 
                405                 410                 415     

Glu Ala Ala Ala Glu Leu Ala Asn Gln Thr Gly Arg Glu Ile Ala 
            420                 425                 430     

<210>   633
<211>   428
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   633
Gly Glu Asn Asp Ser Ala Asn Asn Gly Ser Ala Ser Ala Asn Asn Asp 
                5                   10                  15      

Asp Ala Asn Glu Asn Asn Asn Ala Gly Asp Gly Asp Glu Asp Ile Ser 
            20                  25                  30          

Gly Glu Val Thr Ala Trp Gly Trp Asn Val Ala Ala Ala Ala Met Glu 
        35                  40                  45              

Gln Ala Ile Glu Gly Phe Asn Glu Leu Tyr Pro Asn Val Thr Val Asn 
    50                  55                  60                  

Ile Glu Asp Ile Gly Arg Glu Asp Val Tyr Asp Arg Leu Thr Val Gly 
65                  70                  75                  80  

Leu Ala Ala Gly Gly Ser Gly Leu Pro Asp Ile Ser Met Val Glu Thr 
                85                  90                  95      

Asp Arg Leu Asp Asn Tyr Phe Ala Glu Phe Pro Gln Gly Phe Val Asn 
            100                 105                 110         

Leu Asp Glu Tyr Gly Phe Asn Glu His Glu Asp Lys Phe Ala Asp Ser 
        115                 120                 125             

Lys Val Glu Ala Val Lys Gly Pro Asp Gly Asn Asn Leu Ala Ala Pro 
    130                 135                 140                 

Trp Asp Ile Gly Pro Ala Gly Val Phe Tyr Tyr Val Pro His Phe Glu 
145                 150                 155                 160 

Glu Ala Gly Val Asp Pro Asp Asp Ile Glu Thr Trp Asp Asp Phe Ile 
                165                 170                 175     

Ala Ala Gly Glu Asp Ile Leu Asp Ala Thr Gly Ala Ala Met Val Pro 
            180                 185                 190         

Val Asp Ile Ala Asn Asp Asp Ala Ile Phe Arg Met Met Met Asn Gln 
        195                 200                 205             

Leu Gly Val Tyr Tyr Phe Asp Ala Asp Gly Ala Ile Glu Ile Ala Ser 
    210                 215                 220                 

Asp Asp Ala Ala Leu Ala Met Ser Lys Ile Gln Glu Met His Glu Lys 
225                 230                 235                 240 

Asp Leu Val Ala Asn Val Asp Gly Trp Asp Gly Thr Val Thr Ser Thr 
                245                 250                 255     

Val Asn His Thr Val Ala Thr Ile Pro Phe Gly Val Trp Tyr Ala Gly 
            260                 265                 270         

Thr Ile Thr Asp Gln Ala Pro Asp Gln Ser Gly Asp Trp Gly Val Phe 
        275                 280                 285             

Lys Leu Pro Ala Phe Glu Glu Gly Gly Asn Arg Asp Ala Asn Leu Gly 
    290                 295                 300                 

Gly Ser Asp Leu Thr Ile Leu Ser Ser Thr Glu Tyr Pro Glu Ala Ala 
305                 310                 315                 320 

Tyr Ala Phe Val Glu Tyr Phe Thr Thr Glu Ile Glu Pro Gln Ile Glu 
                325                 330                 335     

Gly Met Thr Glu Tyr Gly Leu Phe Pro Ser Leu Leu Ala Thr Tyr Asp 
            340                 345                 350         

Glu Pro Tyr Phe Gln Glu Asn Asn Glu Phe Phe Asn Asp Glu Pro Ile 
        355                 360                 365             

Trp Ser Leu Phe Ala Asp Val Val Glu Gly Thr Leu Pro Ala Asn Tyr 
    370                 375                 380                 

Thr Asn Asp Tyr Ala Arg Ala Phe Arg Tyr Ala Ser Asp Ala Gln Ala 
385                 390                 395                 400 

Asn Ala Leu Leu Ser Gly Glu Asp Val Gln Val Ala Leu Gln Glu Ala 
                405                 410                 415     

Ala Glu Arg Ile Ala Asn Glu Thr Gly Arg Asp Ile 
            420                 425             

<210>   634
<211>   423
<212>   PRT
<213>   Rhizobium leguminosarum bv. trifolii WSM1325

<400>   634
Met Arg Phe Lys Leu Leu Ala Ala Thr Ala Ala Val Ala Val Leu Ala 
                5                   10                  15      

Ser Gly Ser Ala Tyr Ala Gln Ser Ala Asn Leu Thr Ile Trp Ser Trp 
            20                  25                  30          

Asn Val Ala Ala Ser Ala Leu Lys Ser Thr Leu Pro Gly Phe Asn Lys 
        35                  40                  45              

Gln Phe Pro Asp Ile Lys Ile Thr Val Glu Asp Leu Gly Asn Ser Gln 
    50                  55                  60                  

Val Phe Asp Lys Thr Leu Ala Ala Cys Ala Ala Gly Gly Asp Gly Leu 
65                  70                  75                  80  

Pro Asp Ile Val Ser Ile Glu Asn Phe Glu Ala Glu Ile Phe Trp Ser 
                85                  90                  95      

Arg Phe Pro Asp Cys Phe Ala Asn Leu Lys Glu Leu Gly Tyr Thr Ala 
            100                 105                 110         

Asp Ile Gln Ala Lys Phe Pro Asp Phe Lys Arg Thr Glu Leu Glu Val 
        115                 120                 125             

Gly Asp Val Ala Tyr Ala Met Pro Trp Asp Ser Gly Pro Val Ala Val 
    130                 135                 140                 

Phe Tyr Arg Arg Asp Leu Tyr Glu Lys Ala Gly Val Asp Pro Ser Thr 
145                 150                 155                 160 

Ile Ser Thr Trp Asp Asp Phe Ile Ala Ala Gly Lys Lys Ile Ser Ala 
                165                 170                 175     

Ala Asn Pro Gly Val Val Met Ala Gln Ala Asp Phe Asn Gly Asp Ser 
            180                 185                 190         

Glu Trp Phe Arg Met Ile Ala Asn Glu Gln Gly Cys Gly Tyr Tyr Ser 
        195                 200                 205             

Thr Asp Gly Gln Asn Ile Thr Ile Asn Gln Pro Ala Cys Val Ala Thr 
    210                 215                 220                 

Leu Gln Lys Val Lys Glu Met Lys Asp Ala Gly Thr Leu Thr Ala Ala 
225                 230                 235                 240 

Asn Trp Glu Glu Lys Ile Gln Ala Asp Thr Ala Gly Lys Ala Ala Ser 
                245                 250                 255     

Gln Leu Tyr Gly Gly Trp Tyr Glu Gly Thr Val Arg Ser Thr Ser Pro 
            260                 265                 270         

Asp Leu Lys Gly Lys Trp Gly Val Tyr Arg Met Pro Ser Leu Thr Ala 
        275                 280                 285             

Asp Gly Pro His Ala Ala Asn Leu Gly Gly Ser Ser Leu Ala Ile Ser 
    290                 295                 300                 

Ala Thr Ser Ala Asn Lys Glu Ala Ala Trp Lys Phe Val Asn Tyr Ala 
305                 310                 315                 320 

Leu Gly Thr Asp Glu Gly Gln Ile Thr Met Leu Lys Glu Phe Gly Leu 
                325                 330                 335     

Val Pro Ser Leu Leu Ser Ala Glu Lys Asp Pro Phe Val Asn Glu Pro 
            340                 345                 350         

Gln Pro Tyr Trp Gly Gly Gln Lys Val Trp Ala Asp Ile Leu Ala Thr 
        355                 360                 365             

Leu Pro Lys Ile Val Pro Ser Arg Gly Thr Ala Phe Gln Ser Asp Ala 
    370                 375                 380                 

Glu Ala Ile Phe Lys Ala Thr Gln Thr Lys Phe Phe Ala Gly Gly Tyr 
385                 390                 395                 400 

Pro Asp Ala Lys Ala Ala Leu Asp Asp Ala Ala Asn Gln Ile Ala Ser 
                405                 410                 415     

Ala Thr Gly Leu Pro Ile Ala 
            420             

<210>   635
<211>   401
<212>   PRT
<213>   Rhizobium leguminosarum bv. viciae 3841

<400>   635
Gln Ser Ala Asn Leu Thr Ile Trp Ser Trp Asn Val Ala Ala Ser Ala 
                5                   10                  15      

Leu Lys Ser Thr Leu Pro Gly Phe Asn Lys Gln Phe Pro Asp Ile Lys 
            20                  25                  30          

Ile Thr Val Glu Asp Leu Gly Asn Ser Gln Val Phe Asp Lys Thr Leu 
        35                  40                  45              

Ala Ala Cys Ala Ala Gly Gly Asp Gly Leu Pro Asp Ile Val Thr Ile 
    50                  55                  60                  

Glu Asn Phe Glu Ala Glu Ile Phe Trp Ser Arg Phe Pro Asp Cys Phe 
65                  70                  75                  80  

Ala Asn Leu Lys Glu Leu Gly Tyr Thr Ala Asp Ile Gln Ala Lys Phe 
                85                  90                  95      

Pro Glu Phe Lys Arg Thr Glu Leu Glu Val Gly Asp Val Ala Tyr Ala 
            100                 105                 110         

Met Pro Trp Asp Ser Gly Pro Val Ala Val Phe Tyr Arg Arg Asp Phe 
        115                 120                 125             

Tyr Glu Lys Ala Gly Val Asp Pro Ser Thr Ile Asn Thr Trp Asp Asp 
    130                 135                 140                 

Phe Ile Ala Ala Gly Lys Lys Ile Ser Ala Ala Asn Pro Gly Thr Val 
145                 150                 155                 160 

Met Ala Gln Ala Asp Phe Asn Gly Asp Ser Glu Trp Phe Arg Met Ile 
                165                 170                 175     

Ala Asn Glu Gln Gly Cys Gly Tyr Tyr Ser Ala Asp Gly Gln Asn Ile 
            180                 185                 190         

Thr Ile Asn Gln Pro Ala Cys Val Ser Ser Leu Gln Lys Val Lys Glu 
        195                 200                 205             

Met Lys Asp Ala Gly Thr Leu Thr Ala Ala Asn Trp Asp Glu Lys Ile 
    210                 215                 220                 

Gln Ala Asn Thr Ala Gly Lys Ala Ala Ser Gln Leu Tyr Gly Gly Trp 
225                 230                 235                 240 

Tyr Glu Gly Thr Val Arg Ser Thr Ser Pro Asp Leu Lys Gly Lys Trp 
                245                 250                 255     

Gly Val Tyr Lys Met Pro Ser Leu Thr Ala Asp Gly Pro His Ala Ala 
            260                 265                 270         

Asn Leu Gly Gly Ser Ser Leu Ala Ile Ser Ala Thr Ser Ala Asn Lys 
        275                 280                 285             

Glu Ala Ala Trp Lys Phe Val Asn Tyr Ala Leu Gly Thr Asn Glu Gly 
    290                 295                 300                 

Gln Val Thr Met Leu Lys Glu Phe Gly Leu Val Pro Ser Leu Leu Ser 
305                 310                 315                 320 

Ala Val Gln Asp Pro Phe Val Asn Glu Pro Gln Pro Tyr Trp Gly Gly 
                325                 330                 335     

Gln Lys Val Trp Ala Asp Ile Leu Ala Thr Leu Pro Lys Ile Val Pro 
            340                 345                 350         

Ser Arg Gly Thr Ala Phe Gln Ser Asp Ala Glu Ala Ile Phe Lys Ala 
        355                 360                 365             

Thr Gln Thr Lys Phe Phe Ser Gly Gly Tyr Pro Asp Ala Lys Ala Ala 
    370                 375                 380                 

Leu Asp Asp Ala Ala Asn Gln Ile Ala Ser Ala Thr Gly Leu Pro Ile 
385                 390                 395                 400 

Ala 
    

<210>   636
<211>   409
<212>   PRT
<213>   Mesorhizobium loti MAFF303099

<400>   636
Gly Ser Ala Pro Ala Phe Ala Gln Ser Gly Glu Ile Thr Ile Trp Ser 
                5                   10                  15      

Trp Asn Val Ala Ala Ser Ser Leu Lys Ala Thr Val Ala Gly Phe Asn 
            20                  25                  30          

Lys Leu His Pro Asp Ile Lys Val Thr Val Gln Asp Leu Gly Asn Gln 
        35                  40                  45              

Pro Thr Tyr Asp Lys Ser Ile Ala Gly Cys Ala Ala Gly Gly Val Gly 
    50                  55                  60                  

Leu Pro Asp Ile Val Thr Ile Glu Asn Gly Glu Ala Glu Asn Tyr Trp 
65                  70                  75                  80  

Ser Gln Phe Pro Asp Cys Phe Val Asp Leu His Thr Leu Gly Tyr Thr 
                85                  90                  95      

Ser Glu Asp Gln Lys Lys Phe Pro Asp Phe Lys Arg Thr Glu Leu Glu 
            100                 105                 110         

Val Gly Asp Lys Ala Tyr Ala Met Pro Trp Asp Ser Gly Pro Val Ala 
        115                 120                 125             

Ala Phe Tyr Arg Arg Asp Phe Tyr Glu Lys Ala Gly Val Asp Pro Ala 
    130                 135                 140                 

Ser Ile Lys Thr Trp Asp Asp Phe Ile Ala Ala Gly Lys Lys Ile Gln 
145                 150                 155                 160 

Ala Ala Asn Pro Gly Val Ser Met Thr Asn Ala Asp Phe Asn Gly Asp 
                165                 170                 175     

Thr Glu Phe Phe Arg Met Ile Ser Asn Glu Gln Gly Cys Ala Tyr Phe 
            180                 185                 190         

Ala Glu Asp Gly Gln Ser Ile Thr Val Ser Glu Pro Lys Cys Val Asp 
        195                 200                 205             

Ala Leu Thr Lys Val Lys Glu Met Lys Asp Ala Gly Ile Val Ser Ser 
    210                 215                 220                 

Ala Asp Trp Gly Thr Lys Ile Thr Asn Asn Thr Ala Gly Thr Val Ala 
225                 230                 235                 240 

Thr Gln Val Tyr Gly Gly Trp Tyr Glu Gly Thr Ile Arg Thr Glu Ser 
                245                 250                 255     

Ala Gly Glu Asn Gly Lys Trp Gly Val Tyr Leu Met Pro Ser Leu Thr 
            260                 265                 270         

Ala Asp Gly Pro Arg Ala Ala Asn Leu Gly Gly Ser Ser Leu Ala Ile 
        275                 280                 285             

Thr Ser Ala Ser Lys Asn Lys Glu Ala Ala Tyr Glu Tyr Leu Lys Tyr 
    290                 295                 300                 

Thr Leu Gly Thr Asn Glu Gly Gln Ile Thr Met Leu Lys Glu Phe Gly 
305                 310                 315                 320 

Leu Val Pro Ser Leu Val Ser Ala Leu Asn Asp Pro Tyr Val Ser Gln 
                325                 330                 335     

Gly Leu Pro Tyr Trp Gly Gly Gln Ala Val Trp Lys Asp Ile Leu Gly 
            340                 345                 350         

Thr Leu Pro Lys Val Val Pro Ser Arg Gly Thr Gln Phe Gln Ser Asp 
        355                 360                 365             

Ala Glu Ile Ile Val Arg Ala Val Gln Thr Lys Tyr Leu Ala Gly Gly 
    370                 375                 380                 

Tyr Pro Asp Ala Lys Ala Ala Leu Asp Asp Ala Ala Lys Gln Ile Ala 
385                 390                 395                 400 

Ala Ala Thr Gly Leu Pro Val Lys Ser 
                405                 

<210>   637
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   637
Met Arg Ala Lys Lys Ile Arg Tyr Ala Thr Met Ala Ala Ser Val Ala 
                5                   10                  15      

Met Ala Gly Ile Met Ala Ser Gly Cys Gly Thr Ser Thr Ala Ser Arg 
            20                  25                  30          

Thr Gly Thr Ala Pro Thr Gln Gln Glu Ser Ala Ser Thr His Gln Pro 
        35                  40                  45              

Val Thr Ile Thr Val Ala Ser Trp Asn Asp Ala Ala Asp Ser Leu Arg 
    50                  55                  60                  

Ala Glu Ile Pro Gly Phe Glu Lys Lys Tyr Pro Trp Ile Lys Val Asn 
65                  70                  75                  80  

Val Glu Tyr Val Asp Gly Thr Tyr Gln Lys Val Ile Pro Glu Leu Val 
                85                  90                  95      

Ala Gly Asp Ala Pro Asp Ile Ile Gln Val Gln Gln Arg Asp Phe Gln 
            100                 105                 110         

Thr Phe Leu His Lys Phe Pro Gly Asp Phe Val Asp Leu Thr Pro Tyr 
        115                 120                 125             

Met Ser Ser Ile Lys Asn His Ile Ala Pro Val Ala Leu Asp Val Thr 
    130                 135                 140                 

Val Gln Asn Gly His Ile Tyr Ala Ala Pro Trp Asp Leu Gly Pro Ala 
145                 150                 155                 160 

Ala Leu Tyr Tyr Arg Lys Asp Leu Phe Arg Glu Ala Gly Ile Asn Pro 
                165                 170                 175     

Thr Ser Ile Lys Thr Trp Ser Asp Tyr Leu Ala Ala Gly Lys Lys Leu 
            180                 185                 190         

Val Ala His Phe His Gly Lys Val Lys Met Leu Ala Glu Asn Thr Ser 
        195                 200                 205             

Glu Pro Ser Gln Gly Ile Gln Thr Thr Leu Met Ile Leu Val Asn Glu 
    210                 215                 220                 

Leu Gly Gly Ser Tyr Val Asn Gln Asn Gly Asp Ile Asp Phe Leu Asn 
225                 230                 235                 240 

Pro Gln Leu Glu Lys Ala Met Ser Val Ile Gln Gln Trp Gly Lys Ala 
                245                 250                 255     

Gly Ile Val Ala Asp Ala Pro Thr Trp Asn Asp Gly Ile Ala Ala Phe 
            260                 265                 270         

Ala Asn Gly Gln Val Ala Thr Ile Leu Ser Ala Val Trp Tyr Ala Gly 
        275                 280                 285             

Thr Met Met Asn Ser Ala Pro Lys Gln Ser Gly Leu Trp Gly Ile Val 
    290                 295                 300                 

Pro Leu Pro Ala Phe Thr Pro Gly Gly Asn Asn Glu Ala Asp Thr Gly 
305                 310                 315                 320 

Gly Ser Val Leu Ala Ile Thr Lys Asp Ser Lys Asn Val Gln Ala Ala 
                325                 330                 335     

Trp Asp Phe Ile Asn Tyr Cys Leu Tyr Thr Val Pro Gly Glu Asn Val 
            340                 345                 350         

Gln Leu Lys Tyr Gly Leu Phe Pro Ser Trp Asp Ser Tyr Tyr Thr Ala 
        355                 360                 365             

Lys Gly Thr Asp Phe Asp Gln Asn Phe Pro Tyr Phe Gly Met Pro Ile 
    370                 375                 380                 

Tyr Lys Phe Phe Ala Ser Val Ser Lys His Ile Pro Thr Thr Asn Tyr 
385                 390                 395                 400 

Gly Gly Tyr Phe Glu Asp Tyr Ser Gln Pro Leu Ser Gln Ala Tyr Ile 
                405                 410                 415     

Ser Val Phe Lys Gly Ala Asn Ile Glu Gln Ala Leu Gln Thr Ala Glu 
            420                 425                 430         

Thr Asn Ala Ala Arg Ile Ser Gly Gln Pro Ile Ser Asn Gly 
        435                 440                 445     

<210>   638
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   638
Met Arg Ala Lys Lys Ile Arg Tyr Ala Thr Met Ala Ala Ser Val Ala 
                5                   10                  15      

Met Ala Gly Ile Met Ala Ser Gly Cys Gly Thr Ser Thr Ala Ser Arg 
            20                  25                  30          

Thr Gly Thr Ala Pro Thr Gln Gln Glu Ser Ala Ser Thr His Gln Pro 
        35                  40                  45              

Val Thr Ile Thr Val Ala Ser Trp Asn Asp Ala Ala Asp Ser Leu Arg 
    50                  55                  60                  

Ala Glu Ile Pro Gly Phe Glu Lys Lys Tyr Pro Trp Ile Lys Val Asn 
65                  70                  75                  80  

Val Glu Tyr Val Asp Gly Thr Tyr Gln Lys Val Ile Pro Glu Leu Val 
                85                  90                  95      

Ala Gly Asp Ala Pro Asp Ile Ile Gln Val Gln Gln Arg Asp Phe Gln 
            100                 105                 110         

Thr Phe Leu His Lys Phe Pro Gly Asp Phe Val Asp Leu Thr Pro Tyr 
        115                 120                 125             

Met Ser Ser Ile Lys Asn His Ile Ala Pro Val Ala Leu Asp Val Thr 
    130                 135                 140                 

Val Gln Asn Gly His Ile Tyr Ala Ala Pro Trp Asp Leu Gly Pro Ala 
145                 150                 155                 160 

Ala Leu Tyr Tyr Arg Lys Asp Leu Phe Arg Glu Ala Gly Ile Asn Pro 
                165                 170                 175     

Thr Ser Ile Lys Thr Trp Ser Asp Tyr Leu Ala Ala Gly Lys Lys Leu 
            180                 185                 190         

Val Ala His Phe His Gly Lys Val Lys Met Leu Ala Glu Asn Thr Ser 
        195                 200                 205             

Glu Pro Ser Gln Gly Ile Gln Thr Thr Leu Met Ile Leu Val Asn Glu 
    210                 215                 220                 

Leu Gly Gly Ser Tyr Val Asn Gln Asn Gly Asp Ile Asp Phe Leu Asn 
225                 230                 235                 240 

Pro Gln Leu Glu Lys Ala Met Ser Val Ile Gln Gln Trp Gly Lys Ala 
                245                 250                 255     

Gly Ile Val Ala Asp Ala Pro Thr Trp Asn Asp Gly Leu Ala Ala Phe 
            260                 265                 270         

Ala Asn Gly Gln Val Ala Thr Ile Leu Ser Ala Val Trp Tyr Ala Gly 
        275                 280                 285             

Thr Met Met Asn Ser Ala Pro Lys Gln Ser Gly Leu Trp Gly Ile Val 
    290                 295                 300                 

Pro Leu Pro Ala Phe Thr Pro Gly Gly Asn Asn Glu Ala Asp Thr Gly 
305                 310                 315                 320 

Gly Ser Val Leu Ala Ile Thr Lys Asp Ser Lys Asn Val Gln Ala Ala 
                325                 330                 335     

Trp Asp Phe Ile Asn Tyr Cys Leu Tyr Thr Val Pro Gly Glu Asn Val 
            340                 345                 350         

Gln Leu Lys Tyr Gly Leu Phe Pro Ser Trp Glu Ser Tyr Tyr Thr Ala 
        355                 360                 365             

Lys Gly Thr Asp Phe Asp Gln Asn Phe Pro Tyr Phe Gly Met Pro Ile 
    370                 375                 380                 

Tyr Lys Phe Phe Ala Ser Val Ser Lys His Ile Pro Thr Thr Asn Tyr 
385                 390                 395                 400 

Gly Gly Tyr Phe Glu Asp Tyr Ser Gln Pro Leu Ser Gln Ala Tyr Ile 
                405                 410                 415     

Ser Val Phe Lys Gly Ala Asn Ile Glu Gln Ala Leu Gln Thr Ala Glu 
            420                 425                 430         

Thr Asn Ala Ala Arg Ile Ser Gly Gln Pro Ile Ser Asn Gly 
        435                 440                 445     

<210>   639
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   639
Met Arg Ala Lys Lys Ile Arg Tyr Ala Thr Met Ala Ala Ser Val Ala 
                5                   10                  15      

Met Ala Gly Ile Met Ala Ser Gly Cys Gly Thr Ser Thr Ala Ser Arg 
            20                  25                  30          

Thr Gly Thr Ala Pro Thr Gln Gln Glu Ser Ala Ser Thr His Gln Pro 
        35                  40                  45              

Val Thr Ile Thr Val Ala Ser Trp Asn Asp Ala Ala Asp Ser Leu Arg 
    50                  55                  60                  

Ala Glu Ile Pro Gly Phe Glu Lys Lys Tyr Pro Trp Ile Lys Val Asn 
65                  70                  75                  80  

Val Glu Tyr Val Asp Gly Thr Tyr Gln Arg Val Ile Pro Glu Leu Val 
                85                  90                  95      

Ala Gly Asp Ala Pro Asp Ile Ile Gln Val Gln Gln Arg Asp Phe Gln 
            100                 105                 110         

Thr Phe Leu His Lys Phe Pro Gly Asp Phe Val Asp Leu Thr Pro Tyr 
        115                 120                 125             

Met Ser Ser Ile Lys Asn His Ile Ala Pro Val Ala Leu Asp Val Thr 
    130                 135                 140                 

Val Gln Asn Gly His Ile Tyr Ala Ala Pro Trp Asp Leu Gly Pro Ala 
145                 150                 155                 160 

Ala Leu Tyr Tyr Arg Lys Asp Leu Phe Arg Glu Ala Gly Ile Asn Pro 
                165                 170                 175     

Thr Ser Ile Lys Thr Trp Ser Asp Tyr Leu Ala Ala Gly Lys Lys Leu 
            180                 185                 190         

Val Ala His Phe His Gly Lys Val Lys Met Leu Ala Glu Asn Thr Ser 
        195                 200                 205             

Glu Pro Ser Gln Gly Ile Gln Thr Thr Leu Met Ile Leu Val Asn Glu 
    210                 215                 220                 

Leu Gly Gly Ser Tyr Val Asn Gln Asn Gly Asp Ile Asp Phe Leu Asn 
225                 230                 235                 240 

Pro Gln Leu Glu Lys Ala Met Ser Val Ile Gln Gln Trp Gly Lys Ala 
                245                 250                 255     

Gly Ile Val Ala Asp Ala Pro Thr Trp Asn Asp Gly Ile Ala Ala Phe 
            260                 265                 270         

Ala Asn Gly Gln Val Ala Thr Ile Leu Ser Ala Val Trp Tyr Ala Gly 
        275                 280                 285             

Thr Met Met Asn Ser Ala Pro Lys Gln Ser Gly Leu Trp Gly Ile Val 
    290                 295                 300                 

Pro Leu Pro Ala Phe Thr Pro Gly Gly Asn Asn Glu Ala Asp Thr Gly 
305                 310                 315                 320 

Gly Ser Val Leu Ala Ile Thr Lys Asp Ser Lys Asn Val Gln Ala Ala 
                325                 330                 335     

Trp Asp Phe Ile Asn Tyr Cys Leu Tyr Thr Val Pro Gly Glu Asn Val 
            340                 345                 350         

Gln Leu Lys Tyr Gly Leu Phe Pro Ser Trp Glu Ser Tyr Tyr Thr Ala 
        355                 360                 365             

Lys Gly Thr Asp Phe Asp Gln Asn Phe Pro Tyr Phe Gly Met Pro Ile 
    370                 375                 380                 

Tyr Lys Phe Phe Ala Ser Val Ser Lys His Ile Pro Thr Thr Asn Tyr 
385                 390                 395                 400 

Gly Gly Tyr Phe Glu Asp Tyr Ser Gln Pro Leu Ser Gln Ala Tyr Ile 
                405                 410                 415     

Ser Val Phe Lys Gly Ala Asn Ile Glu Gln Ala Leu Gln Thr Ala Glu 
            420                 425                 430         

Thr Asn Ala Ala Arg Ile Ser Gly Gln Pro Ile Ser Asn Gly 
        435                 440                 445     

<210>   640
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   640
Met Arg Ala Lys Lys Ile Arg Tyr Ala Thr Met Ala Ala Ser Val Ala 
                5                   10                  15      

Met Ala Gly Ile Met Ala Ser Gly Cys Gly Thr Ser Thr Ala Ser Arg 
            20                  25                  30          

Thr Gly Thr Ala Pro Thr Gln Gln Glu Ser Ala Ser Thr His Gln Pro 
        35                  40                  45              

Val Thr Ile Thr Val Ala Ser Trp Asn Asp Ala Ala Asp Ser Leu Arg 
    50                  55                  60                  

Ala Glu Ile Pro Gly Phe Glu Lys Lys Tyr Pro Trp Ile Lys Val Asn 
65                  70                  75                  80  

Val Glu Tyr Val Asp Gly Thr Tyr Gln Lys Val Ile Pro Glu Leu Val 
                85                  90                  95      

Ala Gly Asp Ala Pro Asp Ile Ile Gln Val Gln Gln Arg Asp Phe Gln 
            100                 105                 110         

Thr Phe Leu His Lys Phe Pro Gly Asp Phe Val Asp Leu Thr Pro Tyr 
        115                 120                 125             

Met Ser Ser Ile Lys Asn His Ile Ala Pro Val Ala Ile Asp Val Thr 
    130                 135                 140                 

Val Gln Asn Gly His Ile Tyr Ala Ala Pro Trp Asp Leu Gly Pro Ala 
145                 150                 155                 160 

Ala Leu Tyr Tyr Arg Lys Asp Leu Phe Arg Glu Ala Gly Ile Asn Pro 
                165                 170                 175     

Thr Ser Ile Lys Thr Trp Ser Asp Tyr Leu Ala Ala Gly Lys Lys Leu 
            180                 185                 190         

Val Ala His Phe His Gly Lys Val Lys Met Leu Ala Glu Asn Thr Ser 
        195                 200                 205             

Glu Pro Ser Gln Gly Ile Gln Thr Thr Leu Met Ile Leu Val Asn Glu 
    210                 215                 220                 

Leu Gly Gly Ser Tyr Val Asn Gln Asn Gly Asp Ile Asp Phe Leu Asn 
225                 230                 235                 240 

Pro Gln Leu Glu Lys Ala Met Ser Val Ile Gln Gln Trp Gly Lys Ala 
                245                 250                 255     

Gly Ile Val Ala Asp Ala Pro Thr Trp Asn Asp Gly Ile Ala Ala Phe 
            260                 265                 270         

Ala Asn Gly Gln Val Ala Thr Ile Leu Ser Ala Val Trp Tyr Ala Gly 
        275                 280                 285             

Thr Met Met Asn Ser Ala Pro Lys Gln Ser Gly Leu Trp Gly Ile Val 
    290                 295                 300                 

Pro Leu Pro Ala Phe Thr Pro Gly Gly Asn Asn Glu Ala Asp Thr Gly 
305                 310                 315                 320 

Gly Ser Val Leu Ala Ile Thr Lys Asp Ser Lys Asn Val Gln Ala Ala 
                325                 330                 335     

Trp Asp Phe Ile Asn Tyr Cys Leu Tyr Thr Val Pro Gly Glu Asn Val 
            340                 345                 350         

Gln Leu Lys Tyr Gly Leu Phe Pro Ser Trp Glu Ser Tyr Tyr Thr Ala 
        355                 360                 365             

Lys Gly Thr Asp Phe Asp Gln Asn Phe Pro Tyr Phe Gly Met Pro Ile 
    370                 375                 380                 

Tyr Lys Phe Phe Ala Ser Val Ser Lys His Ile Pro Thr Thr Asn Tyr 
385                 390                 395                 400 

Gly Gly Tyr Phe Glu Asp Tyr Ser Gln Pro Leu Ser Gln Ala Tyr Ile 
                405                 410                 415     

Ser Val Phe Lys Gly Ala Asn Ile Glu Gln Ala Leu Gln Thr Ala Glu 
            420                 425                 430         

Thr Asn Ala Ala Arg Ile Ser Gly Gln Pro Ile Ser Asn Gly 
        435                 440                 445     

<210>   641
<211>   446
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 630

<400>   641
Met Arg Ala Lys Lys Ile Arg Tyr Ala Thr Met Ala Ala Ser Val Ala 
                5                   10                  15      

Met Ala Gly Ile Met Ala Ser Gly Cys Gly Thr Ser Thr Ala Ser Arg 
            20                  25                  30          

Thr Gly Thr Ala Pro Thr Gln Gln Glu Ser Ala Ser Thr His Gln Pro 
        35                  40                  45              

Val Thr Ile Thr Val Ala Ser Trp Asn Asp Ala Ala Asp Ser Leu Arg 
    50                  55                  60                  

Ala Glu Ile Pro Gly Phe Glu Lys Lys Tyr Pro Trp Ile Lys Val Asn 
65                  70                  75                  80  

Val Glu Tyr Val Asp Gly Thr Tyr Gln Lys Val Ile Pro Glu Leu Val 
                85                  90                  95      

Ala Gly Asp Ala Pro Asp Ile Ile Gln Val Gln Gln Arg Asp Phe Gln 
            100                 105                 110         

Thr Phe Leu His Lys Phe Pro Gly Asp Phe Val Asp Leu Thr Pro Tyr 
        115                 120                 125             

Met Ser Ser Ile Lys Asn His Ile Ala Pro Val Ala Leu Asp Val Thr 
    130                 135                 140                 

Val Gln Asn Gly His Ile Tyr Ala Ala Pro Trp Asp Leu Gly Pro Ala 
145                 150                 155                 160 

Ala Leu Tyr Tyr Arg Lys Asp Leu Phe Arg Glu Ala Gly Ile Asn Pro 
                165                 170                 175     

Thr Ser Ile Lys Thr Trp Ser Asp Tyr Leu Ala Ala Gly Lys Lys Leu 
            180                 185                 190         

Val Ala His Phe His Gly Lys Val Lys Met Leu Ala Glu Asn Thr Ser 
        195                 200                 205             

Glu Pro Ser Gln Gly Ile Gln Thr Thr Leu Met Ile Leu Val Asn Glu 
    210                 215                 220                 

Leu Gly Gly Ser Tyr Val Asn Gln Asn Gly Asp Ile Asp Phe Leu Asn 
225                 230                 235                 240 

Pro Gln Leu Glu Lys Ala Met Ser Val Ile Gln Gln Trp Gly Lys Ala 
                245                 250                 255     

Gly Ile Val Ala Asp Ala Pro Thr Trp Asn Asp Gly Ile Ala Ala Phe 
            260                 265                 270         

Ala Asn Gly Gln Val Ala Thr Ile Leu Ser Ala Val Trp Tyr Ala Gly 
        275                 280                 285             

Thr Met Met Asn Ser Ala Pro Lys Gln Ser Gly Leu Trp Gly Ile Val 
    290                 295                 300                 

Pro Leu Pro Ala Phe Thr Pro Gly Gly Asn Asn Glu Ala Asp Thr Gly 
305                 310                 315                 320 

Gly Ser Val Leu Ala Ile Thr Lys Asp Ser Lys Asn Val Gln Ala Ala 
                325                 330                 335     

Trp Asp Phe Ile Asn Tyr Cys Leu Tyr Thr Val Pro Gly Glu Asn Val 
            340                 345                 350         

Gln Leu Lys Tyr Gly Leu Phe Pro Ser Trp Glu Ser Tyr Tyr Thr Ala 
        355                 360                 365             

Lys Gly Thr Asp Phe Asp Gln Asn Phe Pro Tyr Phe Gly Met Pro Ile 
    370                 375                 380                 

Tyr Lys Phe Phe Ala Ser Val Ser Lys His Ile Pro Thr Thr Asn Tyr 
385                 390                 395                 400 

Gly Gly Tyr Phe Glu Asp Tyr Ser Gln Pro Leu Ser Gln Ala Tyr Ile 
                405                 410                 415     

Ser Val Phe Lys Gly Ala Asn Ile Glu Gln Ala Leu Asn Thr Ala Glu 
            420                 425                 430         

Thr Asn Ala Ala Arg Ile Ser Gly Gln Pro Ile Ser Asn Gly 
        435                 440                 445     

<210>   642
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   642
atgcgcgcga agaagattag atatgcgaca atggctgcat ctgtagcgat ggcgggaatc       60

atggcttccg gctgcgggac aagtaccgca tcaaggaccg gcactgcgcc gacccaacag      120

gaaagcgctt cgactcacca gcccgtgacg attacggtgg cctcctggaa cgatgctgca      180

gactccttga gggcagagat cccaggattc gaaaaaaaat acccatggat taaagtgaac      240

gtggaatatg tggatgggac gtatcagaag gtgatcccag aacttgttgc cggagacgca      300

cctgatatca tccaggttca gcaacgagat tttcaaactt tcctccataa gtttccggga      360

gattttgtcg atttgactcc gtacatgagc tcaatcaaaa atcatatagc tcctgtcgcg      420

ctggacgtaa ctgtgcaaaa cggtcatatc tacgctgctc cgtgggatct ggggccggct      480

gcgttgtatt accgaaagga cctgttccgc gaagcgggaa ttaatccaac ttcaattaag      540

acctggtctg attaccttgc tgcgggtaag aagttagtcg cacattttca tggaaaggtt      600

aagatgctag ctgagaacac gtcggagcca agccaaggca ttcagacgac cctcatgatc      660

ttggtcaatg agcttggcgg aagttatgtg aatcagaacg gagatattga tttcttaaac      720

cctcaactcg agaaggccat gagtgtgatt cagcagtggg gtaaggcagg gattgtggcg      780

gatgcaccta cgtggaacga cggtatcgct gcgtttgcca atggacaggt tgccacgatt      840

ctgtcggccg tttggtatgc cggcactatg atgaatagtg cgcccaagca aagtggtttg      900

tggggcattg ttccgcttcc ggcattcacg cctggtggga acaatgaagc tgatacgggt      960

ggctctgttt tggcaattac gaaagacagc aagaatgttc aggcggcctg ggacttcatt     1020

aattactgtt tgtataccgt cccgggagag aatgttcagt tgaaatacgg tctgttccct     1080

tcgtgggatt cgtactatac ggctaagggt actgactttg atcagaattt cccttacttc     1140

ggaatgccga tctataagtt cttcgcatcc gtatcgaagc acattccgac taccaactat     1200

ggtggctatt tcgaggatta ctctcaaccg ctatcacaag cttacatttc ggtatttaag     1260

ggcgcgaata tcgaacaagc gcttcagact gccgaaacga atgccgcacg tatctctggt     1320

caacccattt caaatggata a                                               1341


<210>   643
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   643
atgcgcgcga agaagattag atatgcgaca atggctgcat ctgtagcgat ggcgggaatc       60

atggcttccg gctgcgggac aagtaccgca tcaaggaccg gcactgcgcc gacccaacag      120

gaaagcgctt cgactcacca gcccgtgacg attacggtgg cctcctggaa cgatgctgca      180

gactccttga gggcagagat cccaggattc gaaaaaaaat acccatggat taaagtgaac      240

gtggaatatg tggatgggac gtatcagaag gtgatcccag aacttgttgc cggagacgca      300

cctgatatca tccaggttca gcaacgagat tttcaaactt tcctccataa gtttccggga      360

gattttgtcg atttgactcc gtacatgagc tcaatcaaaa atcatatagc tcctgtcgcg      420

ctggacgtaa ctgtgcaaaa cggtcatatc tacgctgctc cgtgggatct ggggccggct      480

gcgttgtatt accgaaagga cctgttccgc gaagcgggaa ttaatccaac ttcaattaag      540

acctggtctg attaccttgc tgcgggtaag aagttagtcg cacattttca tggaaaggtt      600

aagatgctag ctgagaacac gtcggagcca agccaaggca ttcagacgac cctcatgatc      660

ttggtcaatg agcttggcgg aagttatgtg aatcagaacg gagatattga tttcttaaac      720

cctcaactcg agaaggccat gagtgtgatt cagcagtggg gtaaggcagg gattgtggcg      780

gatgcaccta cgtggaacga cggtttagct gcgtttgcca atggacaggt tgccacgatt      840

ctgtcggccg tttggtatgc cggcactatg atgaatagtg cgcccaagca aagtggtttg      900

tggggcattg ttccgcttcc ggcattcacg cctggtggga acaatgaagc tgatacgggt      960

ggctctgttt tggcaattac gaaagacagc aagaatgttc aggcggcctg ggacttcatt     1020

aattactgtt tgtataccgt cccgggagag aatgttcagt tgaaatacgg tctgttccct     1080

tcgtgggagt cgtactatac ggctaagggt actgactttg atcagaattt cccttacttc     1140

ggaatgccga tctataagtt cttcgcatcc gtatcgaagc acattccgac taccaactat     1200

ggtggctatt tcgaggatta ctctcaaccg ctatcacaag cttacatttc ggtatttaag     1260

ggcgcgaata tcgaacaagc gcttcagact gccgaaacga atgccgcacg tatctctggt     1320

caacccattt caaatggata a                                               1341


<210>   644
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   644
atgcgcgcga agaagattag atatgcgaca atggctgcat ctgtagcgat ggcgggaatc       60

atggcttccg gctgcgggac aagtaccgca tcaaggaccg gcactgcgcc gacccaacag      120

gaaagcgctt cgactcacca gcccgtgacg attacggtgg cctcctggaa cgatgctgca      180

gactccttga gggcagagat cccaggattc gaaaaaaaat acccatggat taaagtgaac      240

gtggaatatg tggatgggac gtatcagcgt gtgatcccag aacttgttgc cggagacgca      300

cctgatatca tccaggttca gcaacgagat tttcaaactt tcctccataa gtttccggga      360

gattttgtcg atttgactcc gtacatgagc tcaatcaaaa atcatatagc tcctgtcgcg      420

ctggacgtaa ctgtgcaaaa cggtcatatc tacgctgctc cgtgggatct ggggccggct      480

gcgttgtatt accgaaagga cctgttccgc gaagcgggaa ttaatccaac ttcaattaag      540

acctggtctg attaccttgc tgcgggtaag aagttagtcg cacattttca tggaaaggtt      600

aagatgctag ctgagaacac gtcggagcca agccaaggca ttcagacgac cctcatgatc      660

ttggtcaatg agcttggcgg aagttatgtg aatcagaacg gagatattga tttcttaaac      720

cctcaactcg agaaggccat gagtgtgatt cagcagtggg gtaaggcagg gattgtggcg      780

gatgcaccta cgtggaacga cggtatcgct gcgtttgcca atggacaggt tgccacgatt      840

ctgtcggccg tttggtatgc cggcactatg atgaatagtg cgcccaagca aagtggtttg      900

tggggcattg ttccgcttcc ggcattcacg cctggtggga acaatgaagc tgatacgggt      960

ggctctgttt tggcaattac gaaagacagc aagaatgttc aggcggcctg ggacttcatt     1020

aattactgtt tgtataccgt cccgggagag aatgttcagt tgaaatacgg tctgttccct     1080

tcgtgggagt cgtactatac ggctaagggt actgactttg atcagaattt cccttacttc     1140

ggaatgccga tctataagtt cttcgcatcc gtatcgaagc acattccgac taccaactat     1200

ggtggctatt tcgaggatta ctctcaaccg ctatcacaag cttacatttc ggtatttaag     1260

ggcgcgaata tcgaacaagc gcttcagact gccgaaacga atgccgcacg tatctctggt     1320

caacccattt caaatggata a                                               1341


<210>   645
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   645
atgcgcgcga agaagattag atatgcgaca atggctgcat ctgtagcgat ggcgggaatc       60

atggcttccg gctgcgggac aagtaccgca tcaaggaccg gcactgcgcc gacccaacag      120

gaaagcgctt cgactcacca gcccgtgacg attacggtgg cctcctggaa cgatgctgca      180

gactccttga gggcagagat cccaggattc gaaaaaaaat acccatggat taaagtgaac      240

gtggaatatg tggatgggac gtatcagaag gtgatcccag aacttgttgc cggagacgca      300

cctgatatca tccaggttca gcaacgagat tttcaaactt tcctccataa gtttccggga      360

gattttgtcg atttgactcc gtacatgagc tcaatcaaaa atcatatagc tcctgtcgcg      420

attgacgtaa ctgtgcaaaa cggtcatatc tacgctgctc cgtgggatct ggggccggct      480

gcgttgtatt accgaaagga cctgttccgc gaagcgggaa ttaatccaac ttcaattaag      540

acctggtctg attaccttgc tgcgggtaag aagttagtcg cacattttca tggaaaggtt      600

aagatgctag ctgagaacac gtcggagcca agccaaggca ttcagacgac cctcatgatc      660

ttggtcaatg agcttggcgg aagttatgtg aatcagaacg gagatattga tttcttaaac      720

cctcaactcg agaaggccat gagtgtgatt cagcagtggg gtaaggcagg gattgtggcg      780

gatgcaccta cgtggaacga cggtatcgct gcgtttgcca atggacaggt tgccacgatt      840

ctgtcggccg tttggtatgc cggcactatg atgaatagtg cgcccaagca aagtggtttg      900

tggggcattg ttccgcttcc ggcattcacg cctggtggga acaatgaagc tgatacgggt      960

ggctctgttt tggcaattac gaaagacagc aagaatgttc aggcggcctg ggacttcatt     1020

aattactgtt tgtataccgt cccgggagag aatgttcagt tgaaatacgg tctgttccct     1080

tcgtgggagt cgtactatac ggctaagggt actgactttg atcagaattt cccttacttc     1140

ggaatgccga tctataagtt cttcgcatcc gtatcgaagc acattccgac taccaactat     1200

ggtggctatt tcgaggatta ctctcaaccg ctatcacaag cttacatttc ggtatttaag     1260

ggcgcgaata tcgaacaagc gcttcagact gccgaaacga atgccgcacg tatctctggt     1320

caacccattt caaatggata a                                               1341


<210>   646
<211>   1341
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 631

<400>   646
atgcgcgcga agaagattag atatgcgaca atggctgcat ctgtagcgat ggcgggaatc       60

atggcttccg gctgcgggac aagtaccgca tcaaggaccg gcactgcgcc gacccaacag      120

gaaagcgctt cgactcacca gcccgtgacg attacggtgg cctcctggaa cgatgctgca      180

gactccttga gggcagagat cccaggattc gaaaaaaaat acccatggat taaagtgaac      240

gtggaatatg tggatgggac gtatcagaag gtgatcccag aacttgttgc cggagacgca      300

cctgatatca tccaggttca gcaacgagat tttcaaactt tcctccataa gtttccggga      360

gattttgtcg atttgactcc gtacatgagc tcaatcaaaa atcatatagc tcctgtcgcg      420

ctggacgtaa ctgtgcaaaa cggtcatatc tacgctgctc cgtgggatct ggggccggct      480

gcgttgtatt accgaaagga cctgttccgc gaagcgggaa ttaatccaac ttcaattaag      540

acctggtctg attaccttgc tgcgggtaag aagttagtcg cacattttca tggaaaggtt      600

aagatgctag ctgagaacac gtcggagcca agccaaggca ttcagacgac cctcatgatc      660

ttggtcaatg agcttggcgg aagttatgtg aatcagaacg gagatattga tttcttaaac      720

cctcaactcg agaaggccat gagtgtgatt cagcagtggg gtaaggcagg gattgtggcg      780

gatgcaccta cgtggaacga cggtatcgct gcgtttgcca atggacaggt tgccacgatt      840

ctgtcggccg tttggtatgc cggcactatg atgaatagtg cgcccaagca aagtggtttg      900

tggggcattg ttccgcttcc ggcattcacg cctggtggga acaatgaagc tgatacgggt      960

ggctctgttt tggcaattac gaaagacagc aagaatgttc aggcggcctg ggacttcatt     1020

aattactgtt tgtataccgt cccgggagag aatgttcagt tgaaatacgg tctgttccct     1080

tcgtgggagt cgtactatac ggctaagggt actgactttg atcagaattt cccttacttc     1140

ggaatgccga tctataagtt cttcgcatcc gtatcgaagc acattccgac taccaactat     1200

ggtggctatt tcgaggatta ctctcaaccg ctatcacaag cttacatttc ggtatttaag     1260

ggcgcgaata tcgaacaagc gcttaatact gccgaaacga atgccgcacg tatctctggt     1320

caacccattt caaatggata a                                               1341


<210>   647
<211>   315
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   647
Met Ser Thr Ile Gln Arg Glu Ser Val Val Thr Glu Arg Gly Thr Arg 
                5                   10                  15      

Ser Leu Thr Gln Leu Leu Arg Phe Leu Arg Gln Pro Gly Val Pro Leu 
            20                  25                  30          

Trp Ile Pro Tyr Val Phe Ile Thr Pro Phe Phe Ile Ile Phe Ala Val 
        35                  40                  45              

Phe Met Leu Tyr Pro Ile Val Asp Thr Leu Val Leu Ser Phe Glu Asn 
    50                  55                  60                  

Trp Ser Thr Val Gln Ser Thr Trp Val Gly Ile Gln Asn Tyr Arg Leu 
65                  70                  75                  80  

Val Ile Thr Asp Pro Ala Phe Trp Thr Ser Leu Leu Asn Asp Ala Phe 
                85                  90                  95      

Ile Leu Leu Ile Gln Val Pro Phe Met Leu Phe Ile Ala Thr Leu Leu 
            100                 105                 110         

Ala Val Ala Leu Asn Ala Arg Phe Leu Lys Leu Lys Trp Leu Phe Arg 
        115                 120                 125             

Leu Leu Ile Phe Phe Pro Val Leu Val Asp Ala Val Thr Tyr Thr Ile 
    130                 135                 140                 

Ala Phe Gln Leu Ile Phe Asn Pro Ser Phe Gly Met Met Asn Tyr Leu 
145                 150                 155                 160 

Leu His Leu Val Gly Leu Pro Ser Ile Asn Trp Ile Gly Asn Ser Trp 
                165                 170                 175     

Ala Ala Arg Leu Ala Ile Phe Leu Val Val Thr Trp Arg Trp Thr Gly 
            180                 185                 190         

Tyr Asn Ala Ile Ile Ile Leu Ser Gly Leu Gln Asn Ile Pro Glu Glu 
        195                 200                 205             

Val Tyr Glu Ser Ala Val Val Asp Gly Ala Gly Arg Val Arg Thr Phe 
    210                 215                 220                 

Phe Gln Ile Thr Leu Pro Leu Leu Arg Pro Val Ile Leu Phe Cys Thr 
225                 230                 235                 240 

Ile Leu Ser Thr Val Gly Thr Leu Gln Leu Phe Thr Glu Pro Tyr Ile 
                245                 250                 255     

Leu Thr Gly Gly Gly Pro Gly Asn Ala Thr Glu Thr Pro Met Leu Tyr 
            260                 265                 270         

Leu Tyr Asn Ile Gly Phe Gln Asn Tyr Asn Phe Gly Leu Ala Ser Ala 
        275                 280                 285             

Gly Thr Tyr Ile Leu Thr Thr Ile Ile Ala Ile Leu Ser Tyr Phe Gln 
    290                 295                 300                 

Ile Arg Val Ser Arg Gly Gly Asp Tyr Ser Ala 
305                 310                 315 

<210>   648
<211>   948
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   648
gtgtctacta ttcagcgaga atccgtcgtc acagagagag gaactcgctc gctaacgcag       60

ctattgcgtt ttctgcggca acctggcgtt cctttgtgga taccttatgt gttcattact      120

ccctttttca tcatatttgc tgtttttatg ctctatccga ttgtcgatac tttggtcctc      180

tcctttgaaa actggtccac tgttcagtcg acatgggttg gaattcaaaa ttatcgactc      240

gtgataacag acccagcgtt ttggacttct ctactgaatg acgccttcat tctgcttatt      300

caagttccgt ttatgttgtt cattgctaca ctcctagcgg tcgctttgaa tgcgcgcttt      360

ctcaagctga agtggctgtt caggctcctg atcttcttcc cggttctggt ggacgcggta      420

acgtacacga tagcatttca gttaattttt aatcctagtt tcgggatgat gaactacctt      480

ctgcaccttg tagggctgcc gtctatcaac tggataggga actcgtgggc tgcacggttg      540

gctatttttc ttgtggtgac atggagatgg actggatata acgcgattat catactgtcc      600

ggccttcaaa acattcctga ggaggtatat gaatctgccg tcgtcgacgg agcaggacgc      660

gtgcgtacgt tcttccaaat caccttgcct ttgctgcgtc cggtgattct cttctgtacg      720

atcttatcga ccgttggtac cttacagctt ttcacggaac cgtacattct aacaggcggt      780

ggccccggga atgcaacaga aacaccaatg ttgtatttgt ataacatagg atttcagaac      840

tataacttcg gtctcgcttc ggcaggaacg tacatcttaa cgacgattat tgccatactc      900

tcgtattttc agataagagt ctctcgtggg ggcgactaca gtgcgtga                   948


<210>   649
<211>   274
<212>   PRT
<213>   Thermus brockianus

<400>   649
Pro Phe Leu Phe Leu Thr Pro Tyr Ala Leu Leu Phe Ala Val Phe Trp 
                5                   10                  15      

Ala Trp Pro Ile Ala Tyr Ser Leu Tyr Leu Ser Phe Leu Asn Thr Arg 
            20                  25                  30          

Val Tyr Pro Trp Arg Leu Glu Val Gly Val Asn Trp Gly Arg Leu Leu 
        35                  40                  45              

Gln Asp Pro Phe Phe Trp Thr Ala Leu Lys Asn Thr Leu Phe Ile Leu 
    50                  55                  60                  

Leu Val Gln Val Pro Leu Met Leu Ala Leu Ala Leu Leu Ala Leu Ala 
65                  70                  75                  80  

Leu Asn Ser Ala Leu Leu Arg Ala Lys Gly Phe Phe Arg Phe Ala Phe 
                85                  90                  95      

Phe Ala Pro Val Val Val Gly Ala Val Ala Tyr Ser Ala Val Phe Arg 
            100                 105                 110         

Leu Leu Phe Asn Thr Glu Phe Gly Ala Val Asn Ala Leu Leu Arg Thr 
        115                 120                 125             

Leu Gly His Pro Gly Tyr Asp Trp Leu Tyr Ala Pro Gly Pro Ala Met 
    130                 135                 140                 

Ala Val Ile Ile Ile Ala Leu Thr Trp Arg Trp Thr Gly Tyr Asn Ala 
145                 150                 155                 160 

Ile Ile Leu Leu Ala Gly Leu Gln Ser Ile Pro Lys Glu Leu Tyr Glu 
                165                 170                 175     

Ala Ala Ala Leu Asp Gly Ala Gly Pro Trp Gln Arg Phe Trp His Val 
            180                 185                 190         

Thr Leu Pro Gly Ile Arg Pro Val Leu Leu Phe Ala Leu Ile Leu Ser 
        195                 200                 205             

Ile Ile Gly Thr Leu Gln Leu Phe Thr Glu Pro Phe Leu Ile Thr Gly 
    210                 215                 220                 

Gly Gly Pro Gly Asn Ala Thr Met Thr Leu Gly Val Tyr Leu Tyr Gln 
225                 230                 235                 240 

Gln Gly Phe Arg Ser Phe Asn Phe Gly Tyr Ala Ser Ala Ile Ala Tyr 
                245                 250                 255     

Thr Val Ala Leu Leu Ala Ala Leu Phe Ser Phe Leu Gln Met Arg Leu 
            260                 265                 270         

Trp Arg 
        

<210>   650
<211>   275
<212>   PRT
<213>   Thermus sp. A4

<400>   650
Pro Tyr Leu Phe Leu Ala Pro Tyr Leu Val Phe Phe Gly Leu Phe Trp 
                5                   10                  15      

Ala Trp Pro Ile Val Tyr Ser Phe Tyr Leu Ser Phe Val Asn Thr Arg 
            20                  25                  30          

Val Tyr Pro Trp Arg Leu Glu Pro Ala Leu Asn Trp Gly Arg Leu Leu 
        35                  40                  45              

Gln Asp Pro Phe Phe Ala Val Ala Leu Lys Asn Thr Leu Phe Ile Leu 
    50                  55                  60                  

Ala Val Gln Val Pro Leu Met Leu Ala Leu Ala Leu Leu Leu Ala Leu 
65                  70                  75                  80  

Ala Leu Asn Ser Ala Leu Leu Arg Phe Lys Gly Phe Tyr Arg Phe Ala 
                85                  90                  95      

Phe Phe Ala Pro Val Val Val Gly Ala Val Ala Tyr Ser Ala Val Phe 
            100                 105                 110         

Arg Leu Leu Phe Asn Thr Glu Phe Gly Ala Val Asn Ala Leu Leu Arg 
        115                 120                 125             

Ala Leu Gly His Pro Gly Tyr Asp Trp Leu Tyr Ala Pro Gly Pro Ala 
    130                 135                 140                 

Met Ala Val Ile Ile Val Ala Leu Thr Trp Arg Trp Thr Gly Tyr Asn 
145                 150                 155                 160 

Ala Ile Ile Leu Leu Ala Gly Leu Gln Asn Ile Pro Lys Glu Leu Tyr 
                165                 170                 175     

Glu Ala Ala Ala Ile Asp Gly Ala Gly Pro Trp Gln Gln Phe Arg His 
            180                 185                 190         

Val Thr Leu Pro Gly Ile Arg Pro Val Leu Leu Phe Cys Leu Val Leu 
        195                 200                 205             

Ser Ile Ile Gly Thr Leu Gln Leu Phe Thr Glu Pro Phe Leu Ile Thr 
    210                 215                 220                 

Gly Gly Gly Pro Gly Asn Ala Thr Met Thr Leu Gly Leu Tyr Leu Tyr 
225                 230                 235                 240 

Gln Gln Gly Phe Arg Ser Phe Asn Phe Gly Tyr Ala Ser Thr Ile Ala 
                245                 250                 255     

Tyr Thr Val Ala Leu Leu Ala Ala Ala Phe Ser Phe Val Gln Leu Arg 
            260                 265                 270         

Leu Trp Arg 
        275 

<210>   651
<211>   326
<212>   PRT
<213>   Halorubrum lacusprofundi ATCC 49239

<400>   651
Ser Arg Arg Ala Met Arg Pro Val Trp Asp Arg Val Arg Phe Ala Arg 
                5                   10                  15      

Gln Asp Leu Thr Ala Ala Thr Pro Thr Leu Pro Arg Val Ala Tyr Leu 
            20                  25                  30          

Phe Ile Ala Pro Phe Phe Leu Leu Phe Ser Val Phe Leu Ala Phe Pro 
        35                  40                  45              

Val Phe Tyr Thr Leu Tyr Leu Ser Phe Phe Glu Tyr Gln Gly Val Gly 
    50                  55                  60                  

Gln Gly Ser Leu Phe Trp Ile Asp Leu Gly Pro Val Tyr Ile Glu Ile 
65                  70                  75                  80  

Pro Gln Ile Ala Gln Leu Asn Phe Val Gly Leu Gly Asn Tyr Ala Arg 
                85                  90                  95      

Leu Leu Gly Asn Asp Leu Phe Trp Gln Ser Met Phe Asn Thr Ser Tyr 
            100                 105                 110         

Ile Leu Val Ile Gln Val Pro Leu Met Ile Gly Leu Ala Leu Ala Leu 
        115                 120                 125             

Ala Leu Ala Leu Asn Ala Ser Phe Leu Arg Leu Lys Gly Val Phe Arg 
    130                 135                 140                 

Thr Ala Ile Ala Leu Pro Val Ser Ala Asn Leu Val Ala Tyr Ser Thr 
145                 150                 155                 160 

Val Phe Leu Leu Leu Phe Asn Glu Gln Leu Gly Phe Leu Asn Tyr Val 
                165                 170                 175     

Leu Ala Gly Val Gly Ile Gly Pro Val Pro Trp Leu Thr Asp Gly Phe 
            180                 185                 190         

Trp Ala Arg Asn Thr Ile Ile Ala Ala Val Thr Trp Arg Trp Thr Gly 
        195                 200                 205             

Tyr Asn Met Ile Ile Leu Leu Ala Gly Leu Gln Thr Ile Pro Gln Gln 
    210                 215                 220                 

Leu Tyr Glu Ala Ala Glu Ile Asp Gly Ala Asn Arg Trp Glu Lys Phe 
225                 230                 235                 240 

Arg Tyr Val Thr Leu Pro Gln Leu Lys Pro Val Met Leu Phe Val Val 
                245                 250                 255     

Val Leu Ser Thr Ile Gly Thr Phe Lys Leu Phe Ala Glu Pro Tyr Val 
            260                 265                 270         

Ile Thr Gly Gly Gly Pro Thr Asn Ser Thr Ile Thr Ile Val Gln Tyr 
        275                 280                 285             

Ile Tyr Arg Gln Ala Phe Val Asn Phe Asn Leu Gly Tyr Ala Ser Ala 
    290                 295                 300                 

Leu Thr Val Val Phe Val Ala Val Val Ser Val Phe Ser Val Val Gln 
305                 310                 315                 320 

Ile Lys Ile Gly Gly Glu 
                325     

<210>   652
<211>   275
<212>   PRT
<213>   Rhizobium leguminosarum bv. viciae 3841

<400>   652
Tyr Ala Phe Leu Ala Pro Tyr Leu Leu Ile Phe Ala Thr Phe Trp Val 
                5                   10                  15      

Trp Pro Ile Ile Asn Ser Phe Leu Ile Ser Phe Gln Asn Thr Arg Ile 
            20                  25                  30          

Asn Pro Trp Lys Tyr Ser Phe Gln Ala Asn Trp Gly Arg Leu Phe Tyr 
        35                  40                  45              

Asp Pro Ala Phe Tyr Asn Ala Leu Tyr Asn Thr Leu Ile Ile Leu Val 
    50                  55                  60                  

Ile Gln Val Pro Val Met Ile Ala Leu Ala Thr Val Met Ala Val Met 
65                  70                  75                  80  

Leu Asn Ser Pro Leu Leu Lys Ala Arg Pro Leu Phe Arg Phe Ala Phe 
                85                  90                  95      

Phe Ala Pro Val Val Val Gly Glu Val Ala Tyr Ala Ala Val Phe Arg 
            100                 105                 110         

Leu Met Phe Ser Leu Asp Phe Gly Ile Ile Asn Lys Leu Ile Ser Ala 
        115                 120                 125             

Val Gly Leu Ser Pro Val Ser Trp Phe Asp Asn Ala Asn Ala Ala Met 
    130                 135                 140                 

Ala Leu Ile Ile Leu Ala Val Thr Trp Arg Trp Ala Gly Tyr Asn Ala 
145                 150                 155                 160 

Ile Ile Ile Leu Ala Gly Leu Gln Ser Ile Pro Asp Asp Val Tyr Glu 
                165                 170                 175     

Ala Ala Thr Leu Asp Arg Val Ser Lys Val Gln Gln Phe Phe His Ile 
            180                 185                 190         

Thr Leu Pro Leu Leu Lys Pro Ile Ile Leu Phe Cys Val Val Leu Ser 
        195                 200                 205             

Val Ile Gly Thr Met Gln Leu Phe Thr Glu Pro Phe Leu Ile Thr Asn 
    210                 215                 220                 

Arg Gly Gly Pro Gly Gly Gly Thr Glu Thr Leu Gly Leu Leu Leu Tyr 
225                 230                 235                 240 

Arg Gln Gly Phe Thr Ser Leu Asn Phe Gly Tyr Ala Ser Ala Ile Ala 
                245                 250                 255     

Tyr Thr Met Ala Ala Leu Ala Val Ser Ile Ser Leu Leu Asn Leu Trp 
            260                 265                 270         

Val Gly Arg 
        275 

<210>   653
<211>   277
<212>   PRT
<213>   Agrobacterium tumefaciens str. C58

<400>   653
Ile Ala Tyr Ala Phe Leu Ala Pro Tyr Leu Leu Ile Phe Ala Thr Phe 
                5                   10                  15      

Trp Val Trp Pro Ile Ile Ser Ser Phe Met Leu Ser Phe Gln Asn Thr 
            20                  25                  30          

Arg Ile Asn Pro Trp Arg Phe Ala Pro Ser Met Asn Trp Gly Arg Leu 
        35                  40                  45              

Val Ser Asp Pro Ala Phe Tyr Asn Ala Leu Tyr Asn Thr Leu Ile Ile 
    50                  55                  60                  

Leu Val Ile Gln Val Pro Val Met Ile Ala Leu Ala Thr Val Met Ala 
65                  70                  75                  80  

Val Leu Leu Asn Ser Pro Leu Leu Lys Val Arg Pro Leu Tyr Arg Phe 
                85                  90                  95      

Ala Phe Phe Ala Pro Val Val Val Gly Glu Val Ala Tyr Ala Ala Val 
            100                 105                 110         

Phe Arg Leu Met Phe Ser Ala Asp Phe Gly Ile Ile Asn Lys Leu Ile 
        115                 120                 125             

Thr Ser Val Gly Leu Ser Pro Ile Ser Trp Phe Asp Asn Ala Asn Ala 
    130                 135                 140                 

Ala Met Ala Leu Val Ile Ile Ala Val Thr Trp Arg Trp Ala Gly Tyr 
145                 150                 155                 160 

Asn Ala Ile Ile Ile Leu Ala Gly Leu Gln Ser Ile Pro Gly Asp Val 
                165                 170                 175     

Tyr Glu Ala Ala Thr Leu Asp Lys Val Ser Lys Arg Gln Gln Phe Phe 
            180                 185                 190         

His Ile Thr Leu Pro Leu Leu Lys Pro Ile Ile Leu Phe Cys Val Val 
        195                 200                 205             

Leu Ser Val Ile Gly Thr Met Gln Leu Phe Ala Glu Pro Phe Leu Ile 
    210                 215                 220                 

Thr Asn Arg Gly Gly Pro Gly Gly Gly Thr Glu Thr Leu Gly Leu Phe 
225                 230                 235                 240 

Leu Tyr Arg Gln Gly Phe Thr Ser Leu Asn Phe Gly Tyr Ala Ser Ala 
                245                 250                 255     

Ile Ala Tyr Thr Met Ala Ala Leu Ala Ile Ala Ile Ser Leu Leu Asn 
            260                 265                 270         

Leu Trp Val Gly Arg 
        275         

<210>   654
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   654
Met Ser Thr Ile Gln Arg Glu Ser Val Val Thr Glu Arg Gly Thr Arg 
                5                   10                  15      

Ser Leu Thr Gln Leu Leu Arg Phe Leu Arg Gln Pro Gly Val Pro Leu 
            20                  25                  30          

Trp Ile Pro Tyr Val Phe Ile Thr Pro Phe Phe Ile Ile Phe Ala Val 
        35                  40                  45              

Phe Met Leu Tyr Pro Ile Val Asp Thr Leu Val Leu Ser Phe Glu Asn 
    50                  55                  60                  

Trp Ser Thr Val Gln Ser Thr Trp Val Gly Ile Gln Asn Tyr Arg Leu 
65                  70                  75                  80  

Val Ile Thr Asp Pro Ala Phe Trp Thr Ser Leu Leu Asn Asp Ala Phe 
                85                  90                  95      

Ile Leu Leu Ile Gln Val Pro Phe Met Leu Phe Ile Ala Thr Leu Leu 
            100                 105                 110         

Ala Val Ala Leu Asn Ala Arg Phe Leu Lys Leu Lys Trp Leu Phe Arg 
        115                 120                 125             

Leu Leu Ile Phe Phe Pro Val Leu Val Asp Ala Val Thr Tyr Thr Ile 
    130                 135                 140                 

Ala Phe Gln Leu Ile Phe Asn Pro Ser Phe Gly Met Met Asn Tyr Leu 
145                 150                 155                 160 

Leu His Leu Val Gly Leu Pro Ser Ile Asn Trp Ile Gly Asn Ser Trp 
                165                 170                 175     

Ala Ala Arg Leu Ala Ile Phe Leu Val Val Thr Trp Arg Trp Thr Gly 
            180                 185                 190         

Tyr Asn Ala Ile Ile Ile Leu Ser Gly Leu Gln Asn Ile Pro Glu Glu 
        195                 200                 205             

Val Tyr Glu Ser Ala Val Val Asp Gly Ala Gly Arg Val Arg Thr Phe 
    210                 215                 220                 

Phe Gln Leu Thr Leu Pro Leu Leu Arg Pro Val Ile Leu Phe Cys Thr 
225                 230                 235                 240 

Ile Leu Ser Thr Val Gly Thr Leu Gln Leu Phe Thr Glu Pro Tyr Ile 
                245                 250                 255     

Leu Thr Gly Gly Gly Pro Gly Asn Ala Thr Glu Thr Pro Met Leu Tyr 
            260                 265                 270         

Leu Tyr Asn Ile Gly Phe Gln Asn Tyr Asn Phe Gly Leu Ala Ser Ala 
        275                 280                 285             

Gly Thr Tyr Ile Leu Thr Thr Ile Ile Ala Ile Leu Ser Tyr Phe Gln 
    290                 295                 300                 

Ile Arg Val Ser Arg Gly Gly Asp Tyr Ser Ala 
305                 310                 315 

<210>   655
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   655
Met Ser Thr Ile Gln Arg Glu Ser Val Val Thr Glu Arg Gly Thr Arg 
                5                   10                  15      

Ser Leu Thr Gln Leu Leu Arg Phe Leu Arg Gln Pro Gly Val Pro Leu 
            20                  25                  30          

Trp Ile Pro Tyr Val Phe Ile Thr Pro Phe Phe Ile Ile Phe Ala Val 
        35                  40                  45              

Phe Met Leu Tyr Pro Ile Val Asp Thr Leu Val Leu Ser Phe Glu Asn 
    50                  55                  60                  

Trp Ser Thr Val Gln Ser Thr Trp Ile Gly Ile Gln Asn Tyr Arg Leu 
65                  70                  75                  80  

Val Ile Thr Asp Pro Ala Phe Trp Thr Ser Leu Leu Asn Asp Ala Phe 
                85                  90                  95      

Ile Leu Leu Ile Gln Val Pro Phe Met Leu Phe Ile Ala Thr Leu Leu 
            100                 105                 110         

Ala Val Ala Leu Asn Ala Arg Phe Leu Lys Leu Lys Trp Leu Phe Arg 
        115                 120                 125             

Leu Leu Ile Phe Phe Pro Val Leu Val Asp Ala Val Thr Tyr Thr Ile 
    130                 135                 140                 

Ala Phe Gln Leu Ile Phe Asn Pro Ser Phe Gly Met Met Asn Tyr Leu 
145                 150                 155                 160 

Leu His Leu Val Gly Leu Pro Ser Ile Asn Trp Ile Gly Asn Ser Trp 
                165                 170                 175     

Ala Ala Arg Leu Ala Ile Phe Leu Val Val Thr Trp Arg Trp Thr Gly 
            180                 185                 190         

Tyr Asn Ala Ile Ile Ile Leu Ser Gly Leu Gln Asn Ile Pro Glu Glu 
        195                 200                 205             

Val Tyr Glu Ser Ala Val Val Asp Gly Ala Gly Arg Val Arg Thr Phe 
    210                 215                 220                 

Phe Gln Ile Thr Leu Pro Leu Leu Arg Pro Val Ile Leu Phe Cys Thr 
225                 230                 235                 240 

Ile Leu Ser Thr Val Gly Thr Leu Gln Leu Phe Thr Glu Pro Tyr Ile 
                245                 250                 255     

Leu Thr Gly Gly Gly Pro Gly Asn Ala Thr Glu Thr Pro Met Leu Tyr 
            260                 265                 270         

Leu Tyr Asn Ile Gly Phe Gln Asn Tyr Asn Phe Gly Leu Ala Ser Ala 
        275                 280                 285             

Gly Thr Tyr Ile Leu Thr Thr Ile Ile Ala Ile Leu Ser Tyr Phe Gln 
    290                 295                 300                 

Ile Arg Val Ser Arg Gly Gly Asp Tyr Ser Ala 
305                 310                 315 

<210>   656
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   656
Met Ser Thr Ile Gln Arg Glu Ser Val Val Thr Glu Arg Gly Thr Arg 
                5                   10                  15      

Ser Leu Thr Gln Leu Leu Arg Phe Leu Arg Gln Pro Gly Val Pro Leu 
            20                  25                  30          

Trp Ile Pro Tyr Val Phe Ile Thr Pro Phe Phe Ile Ile Phe Ala Val 
        35                  40                  45              

Phe Met Leu Tyr Pro Ile Val Asp Thr Leu Val Leu Ser Phe Glu Asn 
    50                  55                  60                  

Trp Ser Thr Val Gln Ser Thr Trp Val Gly Ile Asn Asn Tyr Arg Leu 
65                  70                  75                  80  

Val Ile Thr Asp Pro Ala Phe Trp Thr Ser Leu Leu Asn Asp Ala Phe 
                85                  90                  95      

Ile Leu Leu Ile Gln Val Pro Phe Met Leu Phe Ile Ala Thr Leu Leu 
            100                 105                 110         

Ala Val Ala Leu Asn Ala Arg Phe Leu Lys Leu Lys Trp Leu Phe Arg 
        115                 120                 125             

Leu Leu Ile Phe Phe Pro Val Leu Val Asp Ala Val Thr Tyr Thr Ile 
    130                 135                 140                 

Ala Phe Gln Leu Ile Phe Asn Pro Ser Phe Gly Met Met Asn Tyr Leu 
145                 150                 155                 160 

Leu His Leu Val Gly Leu Pro Ser Ile Asn Trp Ile Gly Asn Ser Trp 
                165                 170                 175     

Ala Ala Arg Leu Ala Ile Phe Leu Val Val Thr Trp Arg Trp Thr Gly 
            180                 185                 190         

Tyr Asn Ala Ile Ile Ile Leu Ser Gly Leu Gln Asn Ile Pro Glu Glu 
        195                 200                 205             

Val Tyr Glu Ser Ala Val Val Asp Gly Ala Gly Arg Val Arg Thr Phe 
    210                 215                 220                 

Phe Gln Ile Thr Leu Pro Leu Leu Arg Pro Val Ile Leu Phe Cys Thr 
225                 230                 235                 240 

Ile Leu Ser Thr Val Gly Thr Leu Gln Leu Phe Thr Glu Pro Tyr Ile 
                245                 250                 255     

Leu Thr Gly Gly Gly Pro Gly Asn Ala Thr Glu Thr Pro Met Leu Tyr 
            260                 265                 270         

Leu Tyr Asn Ile Gly Phe Gln Asn Tyr Asn Phe Gly Leu Ala Ser Ala 
        275                 280                 285             

Gly Thr Tyr Ile Leu Thr Thr Ile Ile Ala Ile Leu Ser Tyr Phe Gln 
    290                 295                 300                 

Ile Arg Val Ser Arg Gly Gly Asp Tyr Ser Ala 
305                 310                 315 

<210>   657
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   657
Met Ser Thr Ile Gln Arg Glu Ser Val Val Thr Glu Arg Gly Thr Arg 
                5                   10                  15      

Ser Leu Thr Gln Leu Leu Arg Phe Leu Arg Gln Pro Gly Val Pro Leu 
            20                  25                  30          

Trp Ile Pro Tyr Val Phe Ile Thr Pro Phe Phe Ile Ile Phe Ala Val 
        35                  40                  45              

Phe Met Ile Tyr Pro Ile Val Asp Thr Leu Val Leu Ser Phe Glu Asn 
    50                  55                  60                  

Trp Ser Thr Val Gln Ser Thr Trp Val Gly Ile Gln Asn Tyr Arg Leu 
65                  70                  75                  80  

Val Ile Thr Asp Pro Ala Phe Trp Thr Ser Leu Leu Asn Asp Ala Phe 
                85                  90                  95      

Ile Leu Leu Ile Gln Val Pro Phe Met Leu Phe Ile Ala Thr Leu Leu 
            100                 105                 110         

Ala Val Ala Leu Asn Ala Arg Phe Leu Lys Leu Lys Trp Leu Phe Arg 
        115                 120                 125             

Leu Leu Ile Phe Phe Pro Val Leu Val Asp Ala Val Thr Tyr Thr Ile 
    130                 135                 140                 

Ala Phe Gln Leu Ile Phe Asn Pro Ser Phe Gly Met Met Asn Tyr Leu 
145                 150                 155                 160 

Leu His Leu Val Gly Leu Pro Ser Ile Asn Trp Ile Gly Asn Ser Trp 
                165                 170                 175     

Ala Ala Arg Leu Ala Ile Phe Leu Val Val Thr Trp Arg Trp Thr Gly 
            180                 185                 190         

Tyr Asn Ala Ile Ile Ile Leu Ser Gly Leu Gln Asn Ile Pro Glu Glu 
        195                 200                 205             

Val Tyr Glu Ser Ala Val Val Asp Gly Ala Gly Arg Val Arg Thr Phe 
    210                 215                 220                 

Phe Gln Ile Thr Leu Pro Leu Leu Arg Pro Val Ile Leu Phe Cys Thr 
225                 230                 235                 240 

Ile Leu Ser Thr Val Gly Thr Leu Gln Leu Phe Thr Glu Pro Tyr Ile 
                245                 250                 255     

Leu Thr Gly Gly Gly Pro Gly Asn Ala Thr Glu Thr Pro Met Leu Tyr 
            260                 265                 270         

Leu Tyr Asn Ile Gly Phe Gln Asn Tyr Asn Phe Gly Leu Ala Ser Ala 
        275                 280                 285             

Gly Thr Tyr Ile Leu Thr Thr Ile Ile Ala Ile Leu Ser Tyr Phe Gln 
    290                 295                 300                 

Ile Arg Val Ser Arg Gly Gly Asp Tyr Ser Ala 
305                 310                 315 

<210>   658
<211>   315
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 647

<400>   658
Met Ser Thr Ile Gln Arg Glu Ser Val Val Thr Glu Arg Gly Thr Arg 
                5                   10                  15      

Ser Leu Thr Gln Leu Leu Arg Phe Leu Arg Asn Pro Gly Val Pro Leu 
            20                  25                  30          

Trp Ile Pro Tyr Val Phe Ile Thr Pro Phe Phe Ile Ile Phe Ala Val 
        35                  40                  45              

Phe Met Leu Tyr Pro Ile Val Asp Thr Leu Val Leu Ser Phe Glu Asn 
    50                  55                  60                  

Trp Ser Thr Val Gln Ser Thr Trp Val Gly Ile Gln Asn Tyr Arg Leu 
65                  70                  75                  80  

Val Ile Thr Asp Pro Ala Phe Trp Thr Ser Leu Leu Asn Asp Ala Phe 
                85                  90                  95      

Ile Leu Leu Ile Gln Val Pro Phe Met Leu Phe Ile Ala Thr Leu Leu 
            100                 105                 110         

Ala Val Ala Leu Asn Ala Arg Phe Leu Lys Leu Lys Trp Leu Phe Arg 
        115                 120                 125             

Leu Leu Ile Phe Phe Pro Val Leu Val Asp Ala Val Thr Tyr Thr Ile 
    130                 135                 140                 

Ala Phe Gln Leu Ile Phe Asn Pro Ser Phe Gly Met Met Asn Tyr Leu 
145                 150                 155                 160 

Leu His Leu Val Gly Leu Pro Ser Ile Asn Trp Ile Gly Asn Ser Trp 
                165                 170                 175     

Ala Ala Arg Leu Ala Ile Phe Leu Val Val Thr Trp Arg Trp Thr Gly 
            180                 185                 190         

Tyr Asn Ala Ile Ile Ile Leu Ser Gly Leu Gln Asn Ile Pro Glu Glu 
        195                 200                 205             

Val Tyr Glu Ser Ala Val Val Asp Gly Ala Gly Arg Val Arg Thr Phe 
    210                 215                 220                 

Phe Gln Ile Thr Leu Pro Leu Leu Arg Pro Val Ile Leu Phe Cys Thr 
225                 230                 235                 240 

Ile Leu Ser Thr Val Gly Thr Leu Gln Leu Phe Thr Glu Pro Tyr Ile 
                245                 250                 255     

Leu Thr Gly Gly Gly Pro Gly Asn Ala Thr Glu Thr Pro Met Leu Tyr 
            260                 265                 270         

Leu Tyr Asn Ile Gly Phe Gln Asn Tyr Asn Phe Gly Leu Ala Ser Ala 
        275                 280                 285             

Gly Thr Tyr Ile Leu Thr Thr Ile Ile Ala Ile Leu Ser Tyr Phe Gln 
    290                 295                 300                 

Ile Arg Val Ser Arg Gly Gly Asp Tyr Ser Ala 
305                 310                 315 

<210>   659
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   659
gtgtctacta ttcagcgaga atccgtcgtc acagagagag gaactcgctc gctaacgcag       60

ctattgcgtt ttctgcggca acctggcgtt cctttgtgga taccttatgt gttcattact      120

ccctttttca tcatatttgc tgtttttatg ctctatccga ttgtcgatac tttggtcctc      180

tcctttgaaa actggtccac tgttcagtcg acatgggttg gaattcaaaa ttatcgactc      240

gtgataacag acccagcgtt ttggacttct ctactgaatg acgccttcat tctgcttatt      300

caagttccgt ttatgttgtt cattgctaca ctcctagcgg tcgctttgaa tgcgcgcttt      360

ctcaagctga agtggctgtt caggctcctg atcttcttcc cggttctggt ggacgcggta      420

acgtacacga tagcatttca gttaattttt aatcctagtt tcgggatgat gaactacctt      480

ctgcaccttg tagggctgcc gtctatcaac tggataggga actcgtgggc tgcacggttg      540

gctatttttc ttgtggtgac atggagatgg actggatata acgcgattat catactgtcc      600

ggccttcaaa acattcctga ggaggtatat gaatctgccg tcgtcgacgg agcaggacgc      660

gtgcgtacgt tcttccaatt aaccttgcct ttgctgcgtc cggtgattct cttctgtacg      720

atcttatcga ccgttggtac cttacagctt ttcacggaac cgtacattct aacaggcggt      780

ggccccggga atgcaacaga aacaccaatg ttgtatttgt ataacatagg atttcagaac      840

tataacttcg gtctcgcttc ggcaggaacg tacatcttaa cgacgattat tgccatactc      900

tcgtattttc agataagagt ctctcgtggg ggcgactaca gtgcgtga                   948


<210>   660
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   660
gtgtctacta ttcagcgaga atccgtcgtc acagagagag gaactcgctc gctaacgcag       60

ctattgcgtt ttctgcggca acctggcgtt cctttgtgga taccttatgt gttcattact      120

ccctttttca tcatatttgc tgtttttatg ctctatccga ttgtcgatac tttggtcctc      180

tcctttgaaa actggtccac tgttcagtcg acatggattg gaattcaaaa ttatcgactc      240

gtgataacag acccagcgtt ttggacttct ctactgaatg acgccttcat tctgcttatt      300

caagttccgt ttatgttgtt cattgctaca ctcctagcgg tcgctttgaa tgcgcgcttt      360

ctcaagctga agtggctgtt caggctcctg atcttcttcc cggttctggt ggacgcggta      420

acgtacacga tagcatttca gttaattttt aatcctagtt tcgggatgat gaactacctt      480

ctgcaccttg tagggctgcc gtctatcaac tggataggga actcgtgggc tgcacggttg      540

gctatttttc ttgtggtgac atggagatgg actggatata acgcgattat catactgtcc      600

ggccttcaaa acattcctga ggaggtatat gaatctgccg tcgtcgacgg agcaggacgc      660

gtgcgtacgt tcttccaaat caccttgcct ttgctgcgtc cggtgattct cttctgtacg      720

atcttatcga ccgttggtac cttacagctt ttcacggaac cgtacattct aacaggcggt      780

ggccccggga atgcaacaga aacaccaatg ttgtatttgt ataacatagg atttcagaac      840

tataacttcg gtctcgcttc ggcaggaacg tacatcttaa cgacgattat tgccatactc      900

tcgtattttc agataagagt ctctcgtggg ggcgactaca gtgcgtga                   948


<210>   661
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   661
gtgtctacta ttcagcgaga atccgtcgtc acagagagag gaactcgctc gctaacgcag       60

ctattgcgtt ttctgcggca acctggcgtt cctttgtgga taccttatgt gttcattact      120

ccctttttca tcatatttgc tgtttttatg ctctatccga ttgtcgatac tttggtcctc      180

tcctttgaaa actggtccac tgttcagtcg acatgggttg gaattaataa ttatcgactc      240

gtgataacag acccagcgtt ttggacttct ctactgaatg acgccttcat tctgcttatt      300

caagttccgt ttatgttgtt cattgctaca ctcctagcgg tcgctttgaa tgcgcgcttt      360

ctcaagctga agtggctgtt caggctcctg atcttcttcc cggttctggt ggacgcggta      420

acgtacacga tagcatttca gttaattttt aatcctagtt tcgggatgat gaactacctt      480

ctgcaccttg tagggctgcc gtctatcaac tggataggga actcgtgggc tgcacggttg      540

gctatttttc ttgtggtgac atggagatgg actggatata acgcgattat catactgtcc      600

ggccttcaaa acattcctga ggaggtatat gaatctgccg tcgtcgacgg agcaggacgc      660

gtgcgtacgt tcttccaaat caccttgcct ttgctgcgtc cggtgattct cttctgtacg      720

atcttatcga ccgttggtac cttacagctt ttcacggaac cgtacattct aacaggcggt      780

ggccccggga atgcaacaga aacaccaatg ttgtatttgt ataacatagg atttcagaac      840

tataacttcg gtctcgcttc ggcaggaacg tacatcttaa cgacgattat tgccatactc      900

tcgtattttc agataagagt ctctcgtggg ggcgactaca gtgcgtga                   948


<210>   662
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   662
gtgtctacta ttcagcgaga atccgtcgtc acagagagag gaactcgctc gctaacgcag       60

ctattgcgtt ttctgcggca acctggcgtt cctttgtgga taccttatgt gttcattact      120

ccctttttca tcatatttgc tgtttttatg atttatccga ttgtcgatac tttggtcctc      180

tcctttgaaa actggtccac tgttcagtcg acatgggttg gaattcaaaa ttatcgactc      240

gtgataacag acccagcgtt ttggacttct ctactgaatg acgccttcat tctgcttatt      300

caagttccgt ttatgttgtt cattgctaca ctcctagcgg tcgctttgaa tgcgcgcttt      360

ctcaagctga agtggctgtt caggctcctg atcttcttcc cggttctggt ggacgcggta      420

acgtacacga tagcatttca gttaattttt aatcctagtt tcgggatgat gaactacctt      480

ctgcaccttg tagggctgcc gtctatcaac tggataggga actcgtgggc tgcacggttg      540

gctatttttc ttgtggtgac atggagatgg actggatata acgcgattat catactgtcc      600

ggccttcaaa acattcctga ggaggtatat gaatctgccg tcgtcgacgg agcaggacgc      660

gtgcgtacgt tcttccaaat caccttgcct ttgctgcgtc cggtgattct cttctgtacg      720

atcttatcga ccgttggtac cttacagctt ttcacggaac cgtacattct aacaggcggt      780

ggccccggga atgcaacaga aacaccaatg ttgtatttgt ataacatagg atttcagaac      840

tataacttcg gtctcgcttc ggcaggaacg tacatcttaa cgacgattat tgccatactc      900

tcgtattttc agataagagt ctctcgtggg ggcgactaca gtgcgtga                   948


<210>   663
<211>   948
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 648

<400>   663
gtgtctacta ttcagcgaga atccgtcgtc acagagagag gaactcgctc gctaacgcag       60

ctattgcgtt ttctgcggaa tcctggcgtt cctttgtgga taccttatgt gttcattact      120

ccctttttca tcatatttgc tgtttttatg ctctatccga ttgtcgatac tttggtcctc      180

tcctttgaaa actggtccac tgttcagtcg acatgggttg gaattcaaaa ttatcgactc      240

gtgataacag acccagcgtt ttggacttct ctactgaatg acgccttcat tctgcttatt      300

caagttccgt ttatgttgtt cattgctaca ctcctagcgg tcgctttgaa tgcgcgcttt      360

ctcaagctga agtggctgtt caggctcctg atcttcttcc cggttctggt ggacgcggta      420

acgtacacga tagcatttca gttaattttt aatcctagtt tcgggatgat gaactacctt      480

ctgcaccttg tagggctgcc gtctatcaac tggataggga actcgtgggc tgcacggttg      540

gctatttttc ttgtggtgac atggagatgg actggatata acgcgattat catactgtcc      600

ggccttcaaa acattcctga ggaggtatat gaatctgccg tcgtcgacgg agcaggacgc      660

gtgcgtacgt tcttccaaat caccttgcct ttgctgcgtc cggtgattct cttctgtacg      720

atcttatcga ccgttggtac cttacagctt ttcacggaac cgtacattct aacaggcggt      780

ggccccggga atgcaacaga aacaccaatg ttgtatttgt ataacatagg atttcagaac      840

tataacttcg gtctcgcttc ggcaggaacg tacatcttaa cgacgattat tgccatactc      900

tcgtattttc agataagagt ctctcgtggg ggcgactaca gtgcgtga                   948


<210>   664
<211>   275
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   664
Met Arg Glu Ser Ile Pro Val Arg Val Leu Ser Tyr Val Phe Leu Val 
                5                   10                  15      

Ile Ala Val Val Val Ser Ile Tyr Pro Ile Tyr Trp Ile Tyr Val Ala 
            20                  25                  30          

Ser Thr Leu Ser Asp Gly Gln Ile Phe His Phe Pro Pro Ala Asn Trp 
        35                  40                  45              

Phe Gly Gly His Leu Leu Gln Asn Val Arg Met Leu Glu Ser Thr Met 
    50                  55                  60                  

Pro Val Trp Arg Asp Leu Ala Asn Ser Ile Val Val Ser Gly Ile Thr 
65                  70                  75                  80  

Thr Ile Ser Val Val Phe Phe Ser Ala Met Val Gly Phe Ala Phe Ala 
                85                  90                  95      

Lys Tyr Arg Phe Trp Ala Lys Ser Phe Leu Phe Phe Val Val Leu Ile 
            100                 105                 110         

Thr Ile Met Ile Pro Met Gln Thr Thr Leu Ile Pro Leu Phe Ile Ile 
        115                 120                 125             

Val Thr Lys Leu His Trp Glu Asn Thr Tyr Gln Gly Leu Ile Val Pro 
    130                 135                 140                 

Phe Leu Val Asn Gly Phe Gly Val Phe Phe Met Arg Gln Gln Met Gln 
145                 150                 155                 160 

Ser Phe Pro Ser Glu Leu Leu Glu Ala Ser Arg Ile Asp Gly Ala Ser 
                165                 170                 175     

Glu Phe Tyr Thr Phe Phe Arg Ile Val Met Pro Asn Met Leu Pro Ser 
            180                 185                 190         

Met Ala Ala Leu Gly Ile Leu Thr Phe Leu Gln Gln Trp Gly Asn Phe 
        195                 200                 205             

Ile Trp Pro Leu Ile Val Ile Asn Ser Arg Asn Met Ser Thr Val Pro 
    210                 215                 220                 

Leu Met Leu Glu Gln Leu Asp Gln Pro Gly Asn Val Ile His Tyr Gly 
225                 230                 235                 240 

Pro Ile Phe Ala Gly Ala Ala Ile Gly Leu Val Pro Leu Met Ile Val 
                245                 250                 255     

Phe Val Ala Leu Gln Arg Tyr Phe Ile Ser Gly Met Tyr Ser Gly Ser 
            260                 265                 270         

Val Lys Gly 
        275 

<210>   665
<211>   828
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   665
gtgcgtgaaa gcatccctgt cagagttctt agttatgtgt ttttagtcat tgctgttgtc       60

gtgtccattt accctattta ttggatatac gtcgcatcaa ccttgtctga tggtcagatt      120

tttcactttc cacctgctaa ttggtttggg ggtcatctcc tgcaaaatgt gcgtatgctc      180

gagtccacaa tgcctgtgtg gagggacctg gcaaatagta ttgtagtctc aggtattact      240

acgattagcg tggtgttttt ctccgcaatg gtgggcttcg cgtttgcgaa gtaccgtttt      300

tgggcgaaat cttttctatt ctttgtagtg ctaatcacta tcatgatacc tatgcaaacg      360

acactcattc ctctattcat tattgtgact aaattacact gggagaatac ttaccaaggt      420

ttgatagttc cctttcttgt aaatggattc ggtgtcttct tcatgaggca gcaaatgcaa      480

tcattcccct ccgaattgct tgaggcctcg aggatagacg gggccagcga gttttatacg      540

ttctttcgaa ttgtaatgcc aaacatgctg ccctctatgg cagcgttggg catcctcaca      600

tttctacaac aatggggcaa ttttatctgg ccgttgattg taattaatag cagaaacatg      660

tcgaccgttc cgcttatgct cgagcaactt gaccaaccgg gaaatgtcat acattacggt      720

ccaatttttg ctggagcggc tatcggtcta gtaccactga tgatagtctt tgttgctttg      780

cagagatatt ttatatcggg tatgtacagt ggttctgtaa agggatga                   828


<210>   666
<211>   262
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   666
Tyr Thr Ala Leu Met Ile Gly Val Ile Leu Ser Thr Phe Pro Phe Tyr 
                5                   10                  15      

Trp Met Phe Ile Gly Ala Thr Asn Pro Ser Gly Ala Ile Phe Ser Val 
            20                  25                  30          

Pro Pro Asn Leu Leu Pro Gly Asp His Phe Met Glu Asn Phe Arg Asn 
        35                  40                  45              

Leu Asn Glu Gly Val Gly Ile Ile Arg Val Met Met Asn Ser Leu Ile 
    50                  55                  60                  

Ile Ala Leu Thr Phe Thr Phe Phe Ser Val Met Ile Ser Ala Ser Ala 
65                  70                  75                  80  

Gly Tyr Ala Phe Ala Lys Tyr Lys Phe Lys Gly Arg Asp Pro Ile Phe 
                85                  90                  95      

Phe Met Leu Leu Leu Ala Ile Met Ile Pro Tyr His Val Thr Leu Ile 
            100                 105                 110         

Pro Leu Phe Gln Leu Met Ala Asp Leu Gly Trp Leu Asn Thr Tyr Arg 
        115                 120                 125             

Ala Val Ile Leu Pro His Leu Ala Tyr Pro Phe Ala Ile Phe Leu Met 
    130                 135                 140                 

Arg Gln Asn Met Arg Ser Val Pro Asp Ala Leu Ile Glu Ala Ala Arg 
145                 150                 155                 160 

Val Asp Gly Ala Gly Glu Phe Lys Ile Phe Phe Arg Val Ile Leu Pro 
                165                 170                 175     

Thr Met Arg Pro Ala Leu Ala Ala Val Ala Ile Phe Leu Phe Met Phe 
            180                 185                 190         

Gln Trp Asn Asn Phe Leu Trp Pro Leu Val Ala Leu Gly Asp Ser Ser 
        195                 200                 205             

Met His Thr Leu Pro Val Ala Leu Ser Gly Leu Val Gly Met Ser Arg 
    210                 215                 220                 

Ile Asp Tyr Gly Gln Ile Met Leu Gly Thr Thr Leu Ser Thr Leu Pro 
225                 230                 235                 240 

Ile Met Ile Phe Phe Leu Leu Leu Gln Lys Gln Phe Ile Ser Gly Ile 
                245                 250                 255     

Leu Gly Gly Ser Val Lys 
            260         

<210>   667
<211>   266
<212>   PRT
<213>   Halorubrum lacusprofundi ATCC 49239

<400>   667
Arg Phe Leu Thr Tyr Ala Phe Val Ile Thr Met Val Val Val Met Met 
                5                   10                  15      

Val Pro Leu Tyr Trp Met Leu Val Ala Ala Thr Leu Pro Gln Glu Gln 
            20                  25                  30          

Phe Leu Gln Phe Pro Pro Arg Leu Ile Pro Gly Thr Ala Phe Leu Asp 
        35                  40                  45              

Asn Phe Ala Ala Leu Gln Glu Arg Leu Asp Phe Val Arg Thr Ile Arg 
    50                  55                  60                  

Asn Ser Val Leu Ile Ala Val Val Tyr Thr Leu Leu Ser Leu Val Leu 
65                  70                  75                  80  

Cys Ser Met Ala Gly Phe Ala Phe Ala Lys Tyr Glu Phe Lys Phe Lys 
                85                  90                  95      

Glu Pro Ile Phe Tyr Thr Ile Leu Ala Thr Leu Val Leu Pro Ile Gln 
            100                 105                 110         

Leu Leu Val Ile Pro Leu Phe Leu Leu Met Ala Gln Leu Asp Trp Thr 
        115                 120                 125             

Asn Thr Phe Arg Ala Ile Ile Leu Pro Trp Ala Ala Asn Pro Ile Gly 
    130                 135                 140                 

Ile Phe Leu Met Arg Gln Asn Met Lys Ser Ile Pro Asp Ala Leu Leu 
145                 150                 155                 160 

Glu Ser Ala Arg Met Asp Gly Ala Thr Glu Phe Gln Ile Phe Tyr Arg 
                165                 170                 175     

Ile Ala Leu Pro Thr Met Arg Ser Ser Leu Ala Ala Leu Ala Ile Ile 
            180                 185                 190         

Leu Phe Leu Phe Gln Trp Asp Leu Phe Leu Tyr Pro Leu Val Ile Leu 
        195                 200                 205             

Glu Thr Ala Asp Met Tyr Thr Ile Pro Ile Gly Leu Ala Gln Leu Thr 
    210                 215                 220                 

Gly Phe Gln Arg Ile Tyr Tyr Asp Gln Ile Met Val Ala Ala Thr Leu 
225                 230                 235                 240 

Ala Ile Val Pro Met Val Val Leu Phe Leu Val Leu Gln Lys Gln Phe 
                245                 250                 255     

Val Ser Gly Ile Leu Ala Gly Ser Leu Lys 
            260                 265     

<210>   668
<211>   267
<212>   PRT
<213>   Halothermothrix orenii H 168

<400>   668
Lys Ala Leu Leu Tyr Phe Ile Leu Ile Phe Gly Val Leu Ile Thr Phe 
                5                   10                  15      

Phe Pro Phe Tyr Tyr Met Ile Val Leu Ala Thr Arg Ser Val Glu Glu 
            20                  25                  30          

Ile Phe Asn Phe Pro Pro Pro Leu Trp Phe Gly Asn Ala Ala Gln Glu 
        35                  40                  45              

Asn Ile Gln Ile Leu Leu Asp Lys Leu Pro Phe Phe Gln Asn Ile Phe 
    50                  55                  60                  

Asn Ser Ile Ile Val Ala Thr Leu Ala Thr Leu Leu Val Leu Phe Phe 
65                  70                  75                  80  

Cys Ser Leu Gly Gly Tyr Gly Phe Ala Lys Tyr Asn Phe Arg Gly Lys 
                85                  90                  95      

Glu Lys Leu Phe Phe Leu Met Leu Ala Ser Met Met Ile Pro Pro Leu 
            100                 105                 110         

Leu Ser Ile Ile Pro Trp Phe Ile Met Met Lys Ala Phe Gly Trp Ile 
        115                 120                 125             

Asn Ser Phe Lys Pro Leu Ile Ile Pro Gly Ala Ala Asn Ala Phe Gly 
    130                 135                 140                 

Ile Phe Leu Met Arg Gln Phe Met Glu Glu Ile Pro Asp Glu Ile Ile 
145                 150                 155                 160 

Asp Ala Ala Arg Ile Asp Gly Ala Gly Glu Phe Glu Ile Tyr Tyr Lys 
                165                 170                 175     

Ile Ala Leu Pro Leu Ser Lys Pro Gly Met Ala Thr Leu Gly Ile Leu 
            180                 185                 190         

Thr Phe Leu Gly Ser Trp Asn Asn Phe Met Gly Pro Leu Leu Val Leu 
        195                 200                 205             

Gln Glu Lys Thr Lys Tyr Thr Ile Pro Val Ala Leu Ser Lys Leu Asn 
    210                 215                 220                 

Gly Asn Phe Glu Thr Pro Trp Gly Ala Thr Met Met Gly Thr Ala Leu 
225                 230                 235                 240 

Gly Val Phe Pro Ile Val Leu Ala Phe Val Leu Ala Ser Lys Tyr Phe 
                245                 250                 255     

Ile Ser Gly Leu Thr Thr Gly Ala Thr Lys Gly 
            260                 265         

<210>   669
<211>   262
<212>   PRT
<213>   Bacillus clausii KSM-K16

<400>   669
Tyr Val Val Leu Ala Ala Gly Leu Phe Ile Thr Leu Gly Pro Phe Tyr 
                5                   10                  15      

Trp Met Val Val Gly Ala Thr Asn Ser Ser Gly Ala Leu Leu Ser Val 
            20                  25                  30          

Pro Pro Asn Val Ile Pro Gly Thr His Leu Leu Glu Asn Ala Arg Asn 
        35                  40                  45              

Leu Leu Asn Asn Ile Asp Ile Phe Arg Ala Leu Trp Asn Ser Ile Phe 
    50                  55                  60                  

Ile Thr Val Thr Phe Thr Val Ile Ala Gly Leu Phe Ser Ala Ala Ala 
65                  70                  75                  80  

Gly Tyr Ala Phe Ala Lys Tyr Glu Phe Lys Gly Lys Asn Ala Ile Phe 
                85                  90                  95      

Ser Met Phe Leu Val Ser Met Met Ile Pro Tyr Gln Ala Leu Ile Ile 
            100                 105                 110         

Pro Gln Phe Glu Leu Phe Ala Arg Met Gly Ile Leu Asn Ser Tyr Ser 
        115                 120                 125             

Ala Ile Ile Leu Pro Gln Leu Ala Tyr Pro Phe Ala Ile Phe Leu Met 
    130                 135                 140                 

Arg Gln Ser Met Lys Ser Ile Pro Asp Ser Val Leu Glu Ser Ala Arg 
145                 150                 155                 160 

Ile Asp Gly Cys Gly Glu Tyr Arg Met Phe Phe Gln Ile Ala Leu Pro 
                165                 170                 175     

Thr Met Leu Pro Ala Ile Gly Ala Val Gly Ile Phe Leu Phe Thr His 
            180                 185                 190         

Gln Trp Asn Asn Phe Leu Trp Pro Leu Val Val Ile Val Thr Glu Asp 
        195                 200                 205             

Met Tyr Thr Leu Pro Ile Val Leu Ser Ile Leu Gly Gly Gln Asp Asn 
    210                 215                 220                 

Leu Asp Tyr Gly Gln Leu Met Leu Ala Ala Thr Ile Ser Val Leu Pro 
225                 230                 235                 240 

Ile Phe Ile Met Phe Leu Phe Leu Gln Arg Tyr Phe Ile Ala Gly Ile 
                245                 250                 255     

Ser Ser Gly Ala Val Lys 
            260         

<210>   670
<211>   268
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   670
Tyr Leu Leu Leu Val Val Gly Ala Phe Leu Ser Leu Phe Pro Phe Tyr 
                5                   10                  15      

Tyr Met Phe Val Gln Ala Ser Gln Pro Ser Ser Glu Val Leu Arg Phe 
            20                  25                  30          

Pro Pro His Leu Trp Phe Gly Ser Ala Ala Trp Ser Asn Ile Gln Gly 
        35                  40                  45              

Leu Phe Ala Asn Gly Phe Gly Arg Ser Leu Phe Asn Ser Ala Phe Ile 
    50                  55                  60                  

Ala Val Val Tyr Ala Ser Leu Ser Val Phe Ile Ala Ser Leu Ala Gly 
65                  70                  75                  80  

Tyr Ala Phe Ala Lys Phe Arg Phe Arg Gly Arg Ser Ile Leu Phe Gly 
                85                  90                  95      

Met Phe Leu Leu Val Leu Met Ile Pro Tyr His Val Thr Ala Val Pro 
            100                 105                 110         

Leu Phe Gln Leu Met Ala Lys Ile Thr Leu Phe Gly Asp Pro Thr Trp 
        115                 120                 125             

Ile Ser Ser Tyr Gln Ala Val Ile Leu Pro Ala Leu Ala Asn Pro Phe 
    130                 135                 140                 

Gly Ile Phe Leu Met Arg Gln Ser Met Gln Ser Leu Pro Asp Asp Leu 
145                 150                 155                 160 

Leu Asp Ala Ala Arg Ile Asp Gly Ala Gly Glu Trp Arg Val Phe Thr 
                165                 170                 175     

Ser Val Ala Leu Pro Thr Met Arg Pro Thr Leu Ala Ala Leu Ala Ile 
            180                 185                 190         

Tyr Ser Phe Met Phe Gln Trp Asn Ser Phe Phe Trp Pro Leu Ile Ile 
        195                 200                 205             

Met Arg Asp Lys Ala Met Glu Thr Leu Pro Val Arg Ile Asn Ala Leu 
    210                 215                 220                 

Val Gly Leu Ser Ile Ile Asp Tyr Gly Gln Leu Met Met Gly Thr Ala 
225                 230                 235                 240 

Leu Thr Thr Leu Pro Ile Met Met Ile Phe Ile Ala Phe Gln Arg Gln 
                245                 250                 255     

Phe Ile Ser Gly Ala Leu Ala Gly Ala Val Lys Gly 
            260                 265             

<210>   671
<211>   275
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   671
Met Arg Glu Ser Ile Pro Val Arg Val Leu Ser Tyr Val Phe Leu Val 
                5                   10                  15      

Ile Ala Val Val Val Ser Ile Tyr Pro Ile Tyr Trp Ile Tyr Val Ala 
            20                  25                  30          

Ser Thr Leu Ser Glu Gly Gln Ile Phe His Phe Pro Pro Ala Asn Trp 
        35                  40                  45              

Phe Gly Gly His Leu Leu Gln Asn Val Arg Met Leu Glu Ser Thr Met 
    50                  55                  60                  

Pro Val Trp Arg Asp Leu Ala Asn Ser Ile Val Val Ser Gly Ile Thr 
65                  70                  75                  80  

Thr Ile Ser Val Val Phe Phe Ser Ala Met Val Gly Phe Ala Phe Ala 
                85                  90                  95      

Lys Tyr Arg Phe Trp Ala Lys Ser Phe Leu Phe Phe Val Val Leu Ile 
            100                 105                 110         

Thr Ile Met Ile Pro Met Gln Thr Thr Leu Ile Pro Leu Phe Ile Ile 
        115                 120                 125             

Val Thr Lys Leu His Trp Glu Asn Thr Tyr Gln Gly Leu Ile Val Pro 
    130                 135                 140                 

Phe Leu Val Asn Gly Phe Gly Val Phe Phe Met Arg Gln Gln Met Gln 
145                 150                 155                 160 

Ser Phe Pro Ser Glu Leu Leu Glu Ala Ser Arg Ile Asp Gly Ala Ser 
                165                 170                 175     

Glu Phe Tyr Thr Phe Phe Arg Ile Val Met Pro Asn Met Leu Pro Ser 
            180                 185                 190         

Met Ala Ala Leu Gly Ile Leu Thr Phe Leu Gln Gln Trp Gly Asn Phe 
        195                 200                 205             

Ile Trp Pro Leu Ile Val Ile Asn Ser Arg Asn Met Ser Thr Val Pro 
    210                 215                 220                 

Leu Met Leu Glu Gln Leu Asp Gln Pro Gly Asn Val Ile His Tyr Gly 
225                 230                 235                 240 

Pro Ile Phe Ala Gly Ala Ala Ile Gly Leu Val Pro Leu Met Ile Val 
                245                 250                 255     

Phe Val Ala Leu Gln Arg Tyr Phe Ile Ser Gly Met Tyr Ser Gly Ser 
            260                 265                 270         

Val Lys Gly 
        275 

<210>   672
<211>   275
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   672
Met Arg Glu Ser Ile Pro Val Arg Val Leu Ser Tyr Val Phe Leu Val 
                5                   10                  15      

Ile Ala Val Val Val Ser Ile Tyr Pro Ile Tyr Trp Ile Tyr Val Ala 
            20                  25                  30          

Ser Thr Leu Ser Asp Gly Gln Ile Phe His Phe Pro Pro Ala Asn Trp 
        35                  40                  45              

Phe Gly Gly His Leu Leu Gln Asn Val Arg Met Leu Glu Ser Thr Met 
    50                  55                  60                  

Pro Val Trp Arg Asp Leu Ala Asn Ser Ile Val Val Ser Gly Ile Thr 
65                  70                  75                  80  

Thr Ile Ser Val Val Phe Phe Ser Ala Met Val Gly Phe Ala Phe Ala 
                85                  90                  95      

Lys Tyr Arg Phe Trp Ala Lys Ser Phe Leu Phe Phe Val Val Leu Ile 
            100                 105                 110         

Thr Ile Met Ile Pro Met Gln Thr Thr Leu Ile Pro Leu Phe Ile Ile 
        115                 120                 125             

Val Thr Lys Leu His Trp Glu Gln Thr Tyr Gln Gly Leu Ile Val Pro 
    130                 135                 140                 

Phe Leu Val Asn Gly Phe Gly Val Phe Phe Met Arg Gln Gln Met Gln 
145                 150                 155                 160 

Ser Phe Pro Ser Glu Leu Leu Glu Ala Ser Arg Ile Asp Gly Ala Ser 
                165                 170                 175     

Glu Phe Tyr Thr Phe Phe Arg Ile Val Met Pro Asn Met Leu Pro Ser 
            180                 185                 190         

Met Ala Ala Leu Gly Ile Leu Thr Phe Leu Gln Gln Trp Gly Asn Phe 
        195                 200                 205             

Ile Trp Pro Leu Ile Val Ile Asn Ser Arg Asn Met Ser Thr Val Pro 
    210                 215                 220                 

Leu Met Leu Glu Gln Leu Asp Gln Pro Gly Asn Val Ile His Tyr Gly 
225                 230                 235                 240 

Pro Ile Phe Ala Gly Ala Ala Ile Gly Leu Val Pro Leu Met Ile Val 
                245                 250                 255     

Phe Val Ala Leu Gln Arg Tyr Phe Ile Ser Gly Met Tyr Ser Gly Ser 
            260                 265                 270         

Val Lys Gly 
        275 

<210>   673
<211>   275
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   673
Met Arg Glu Ser Ile Pro Val Arg Val Leu Ser Tyr Val Phe Leu Ile 
                5                   10                  15      

Ile Ala Val Val Val Ser Ile Tyr Pro Ile Tyr Trp Ile Tyr Val Ala 
            20                  25                  30          

Ser Thr Leu Ser Asp Gly Gln Ile Phe His Phe Pro Pro Ala Asn Trp 
        35                  40                  45              

Phe Gly Gly His Leu Leu Gln Asn Val Arg Met Leu Glu Ser Thr Met 
    50                  55                  60                  

Pro Val Trp Arg Asp Leu Ala Asn Ser Ile Val Val Ser Gly Ile Thr 
65                  70                  75                  80  

Thr Ile Ser Val Val Phe Phe Ser Ala Met Val Gly Phe Ala Phe Ala 
                85                  90                  95      

Lys Tyr Arg Phe Trp Ala Lys Ser Phe Leu Phe Phe Val Val Leu Ile 
            100                 105                 110         

Thr Ile Met Ile Pro Met Gln Thr Thr Leu Ile Pro Leu Phe Ile Ile 
        115                 120                 125             

Val Thr Lys Leu His Trp Glu Asn Thr Tyr Gln Gly Leu Ile Val Pro 
    130                 135                 140                 

Phe Leu Val Asn Gly Phe Gly Val Phe Phe Met Arg Gln Gln Met Gln 
145                 150                 155                 160 

Ser Phe Pro Ser Glu Leu Leu Glu Ala Ser Arg Ile Asp Gly Ala Ser 
                165                 170                 175     

Glu Phe Tyr Thr Phe Phe Arg Ile Val Met Pro Asn Met Leu Pro Ser 
            180                 185                 190         

Met Ala Ala Leu Gly Ile Leu Thr Phe Leu Gln Gln Trp Gly Asn Phe 
        195                 200                 205             

Ile Trp Pro Leu Ile Val Ile Asn Ser Arg Asn Met Ser Thr Val Pro 
    210                 215                 220                 

Leu Met Leu Glu Gln Leu Asp Gln Pro Gly Asn Val Ile His Tyr Gly 
225                 230                 235                 240 

Pro Ile Phe Ala Gly Ala Ala Ile Gly Leu Val Pro Leu Met Ile Val 
                245                 250                 255     

Phe Val Ala Leu Gln Arg Tyr Phe Ile Ser Gly Met Tyr Ser Gly Ser 
            260                 265                 270         

Val Lys Gly 
        275 

<210>   674
<211>   275
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   674
Met Arg Glu Ser Ile Pro Val Arg Val Leu Ser Tyr Val Phe Leu Val 
                5                   10                  15      

Ile Ala Val Val Val Ser Ile Tyr Pro Ile Tyr Trp Leu Tyr Val Ala 
            20                  25                  30          

Ser Thr Leu Ser Asp Gly Gln Ile Phe His Phe Pro Pro Ala Asn Trp 
        35                  40                  45              

Phe Gly Gly His Leu Leu Gln Asn Val Arg Met Leu Glu Ser Thr Met 
    50                  55                  60                  

Pro Val Trp Arg Asp Leu Ala Asn Ser Ile Val Val Ser Gly Ile Thr 
65                  70                  75                  80  

Thr Ile Ser Val Val Phe Phe Ser Ala Met Val Gly Phe Ala Phe Ala 
                85                  90                  95      

Lys Tyr Arg Phe Trp Ala Lys Ser Phe Leu Phe Phe Val Val Leu Ile 
            100                 105                 110         

Thr Ile Met Ile Pro Met Gln Thr Thr Leu Ile Pro Leu Phe Ile Ile 
        115                 120                 125             

Val Thr Lys Leu His Trp Glu Asn Thr Tyr Gln Gly Leu Ile Val Pro 
    130                 135                 140                 

Phe Leu Val Asn Gly Phe Gly Val Phe Phe Met Arg Gln Gln Met Gln 
145                 150                 155                 160 

Ser Phe Pro Ser Glu Leu Leu Glu Ala Ser Arg Ile Asp Gly Ala Ser 
                165                 170                 175     

Glu Phe Tyr Thr Phe Phe Arg Ile Val Met Pro Asn Met Leu Pro Ser 
            180                 185                 190         

Met Ala Ala Leu Gly Ile Leu Thr Phe Leu Gln Gln Trp Gly Asn Phe 
        195                 200                 205             

Ile Trp Pro Leu Ile Val Ile Asn Ser Arg Asn Met Ser Thr Val Pro 
    210                 215                 220                 

Leu Met Leu Glu Gln Leu Asp Gln Pro Gly Asn Val Ile His Tyr Gly 
225                 230                 235                 240 

Pro Ile Phe Ala Gly Ala Ala Ile Gly Leu Val Pro Leu Met Ile Val 
                245                 250                 255     

Phe Val Ala Leu Gln Arg Tyr Phe Ile Ser Gly Met Tyr Ser Gly Ser 
            260                 265                 270         

Val Lys Gly 
        275 

<210>   675
<211>   275
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 664

<400>   675
Met Arg Glu Ser Ile Pro Val Arg Val Leu Ser Tyr Val Phe Leu Val 
                5                   10                  15      

Ile Ala Val Val Val Ser Ile Tyr Pro Ile Tyr Trp Ile Tyr Val Ala 
            20                  25                  30          

Ser Thr Leu Ser Asp Gly Gln Ile Phe His Phe Pro Pro Ala Asn Trp 
        35                  40                  45              

Phe Gly Gly His Leu Leu Gln Asn Val Arg Met Leu Glu Ser Thr Met 
    50                  55                  60                  

Pro Val Trp Arg Asp Leu Ala Asn Ser Ile Val Val Ser Gly Ile Thr 
65                  70                  75                  80  

Thr Ile Ser Val Val Phe Phe Ser Ala Met Val Gly Phe Ala Phe Ala 
                85                  90                  95      

Lys Tyr Arg Phe Trp Ala Lys Ser Phe Leu Phe Phe Val Val Leu Ile 
            100                 105                 110         

Thr Ile Met Ile Pro Met Gln Thr Thr Leu Ile Pro Leu Phe Ile Ile 
        115                 120                 125             

Val Thr Lys Leu His Trp Glu Asn Thr Tyr Gln Gly Leu Ile Val Pro 
    130                 135                 140                 

Phe Leu Val Asn Gly Phe Gly Val Phe Phe Met Arg Gln Gln Met Gln 
145                 150                 155                 160 

Ser Phe Pro Ser Glu Leu Leu Glu Ala Ser Arg Ile Asp Gly Ala Ser 
                165                 170                 175     

Glu Phe Tyr Thr Phe Phe Arg Ile Val Met Pro Gln Met Leu Pro Ser 
            180                 185                 190         

Met Ala Ala Leu Gly Ile Leu Thr Phe Leu Gln Gln Trp Gly Asn Phe 
        195                 200                 205             

Ile Trp Pro Leu Ile Val Ile Asn Ser Arg Asn Met Ser Thr Val Pro 
    210                 215                 220                 

Leu Met Leu Glu Gln Leu Asp Gln Pro Gly Asn Val Ile His Tyr Gly 
225                 230                 235                 240 

Pro Ile Phe Ala Gly Ala Ala Ile Gly Leu Val Pro Leu Met Ile Val 
                245                 250                 255     

Phe Val Ala Leu Gln Arg Tyr Phe Ile Ser Gly Met Tyr Ser Gly Ser 
            260                 265                 270         

Val Lys Gly 
        275 

<210>   676
<211>   828
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   676
gtgcgtgaaa gcatccctgt cagagttctt agttatgtgt ttttagtcat tgctgttgtc       60

gtgtccattt accctattta ttggatatac gtcgcatcaa ccttgtctga aggtcagatt      120

tttcactttc cacctgctaa ttggtttggg ggtcatctcc tgcaaaatgt gcgtatgctc      180

gagtccacaa tgcctgtgtg gagggacctg gcaaatagta ttgtagtctc aggtattact      240

acgattagcg tggtgttttt ctccgcaatg gtgggcttcg cgtttgcgaa gtaccgtttt      300

tgggcgaaat cttttctatt ctttgtagtg ctaatcacta tcatgatacc tatgcaaacg      360

acactcattc ctctattcat tattgtgact aaattacact gggagaatac ttaccaaggt      420

ttgatagttc cctttcttgt aaatggattc ggtgtcttct tcatgaggca gcaaatgcaa      480

tcattcccct ccgaattgct tgaggcctcg aggatagacg gggccagcga gttttatacg      540

ttctttcgaa ttgtaatgcc aaacatgctg ccctctatgg cagcgttggg catcctcaca      600

tttctacaac aatggggcaa ttttatctgg ccgttgattg taattaatag cagaaacatg      660

tcgaccgttc cgcttatgct cgagcaactt gaccaaccgg gaaatgtcat acattacggt      720

ccaatttttg ctggagcggc tatcggtcta gtaccactga tgatagtctt tgttgctttg      780

cagagatatt ttatatcggg tatgtacagt ggttctgtaa agggatga                   828


<210>   677
<211>   828
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   677
gtgcgtgaaa gcatccctgt cagagttctt agttatgtgt ttttagtcat tgctgttgtc       60

gtgtccattt accctattta ttggatatac gtcgcatcaa ccttgtctga tggtcagatt      120

tttcactttc cacctgctaa ttggtttggg ggtcatctcc tgcaaaatgt gcgtatgctc      180

gagtccacaa tgcctgtgtg gagggacctg gcaaatagta ttgtagtctc aggtattact      240

acgattagcg tggtgttttt ctccgcaatg gtgggcttcg cgtttgcgaa gtaccgtttt      300

tgggcgaaat cttttctatt ctttgtagtg ctaatcacta tcatgatacc tatgcaaacg      360

acactcattc ctctattcat tattgtgact aaattacact gggagcaaac ttaccaaggt      420

ttgatagttc cctttcttgt aaatggattc ggtgtcttct tcatgaggca gcaaatgcaa      480

tcattcccct ccgaattgct tgaggcctcg aggatagacg gggccagcga gttttatacg      540

ttctttcgaa ttgtaatgcc aaacatgctg ccctctatgg cagcgttggg catcctcaca      600

tttctacaac aatggggcaa ttttatctgg ccgttgattg taattaatag cagaaacatg      660

tcgaccgttc cgcttatgct cgagcaactt gaccaaccgg gaaatgtcat acattacggt      720

ccaatttttg ctggagcggc tatcggtcta gtaccactga tgatagtctt tgttgctttg      780

cagagatatt ttatatcggg tatgtacagt ggttctgtaa agggatga                   828


<210>   678
<211>   828
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   678
gtgcgtgaaa gcatccctgt cagagttctt agttatgtgt ttttaattat tgctgttgtc       60

gtgtccattt accctattta ttggatatac gtcgcatcaa ccttgtctga tggtcagatt      120

tttcactttc cacctgctaa ttggtttggg ggtcatctcc tgcaaaatgt gcgtatgctc      180

gagtccacaa tgcctgtgtg gagggacctg gcaaatagta ttgtagtctc aggtattact      240

acgattagcg tggtgttttt ctccgcaatg gtgggcttcg cgtttgcgaa gtaccgtttt      300

tgggcgaaat cttttctatt ctttgtagtg ctaatcacta tcatgatacc tatgcaaacg      360

acactcattc ctctattcat tattgtgact aaattacact gggagaatac ttaccaaggt      420

ttgatagttc cctttcttgt aaatggattc ggtgtcttct tcatgaggca gcaaatgcaa      480

tcattcccct ccgaattgct tgaggcctcg aggatagacg gggccagcga gttttatacg      540

ttctttcgaa ttgtaatgcc aaacatgctg ccctctatgg cagcgttggg catcctcaca      600

tttctacaac aatggggcaa ttttatctgg ccgttgattg taattaatag cagaaacatg      660

tcgaccgttc cgcttatgct cgagcaactt gaccaaccgg gaaatgtcat acattacggt      720

ccaatttttg ctggagcggc tatcggtcta gtaccactga tgatagtctt tgttgctttg      780

cagagatatt ttatatcggg tatgtacagt ggttctgtaa agggatga                   828


<210>   679
<211>   828
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   679
gtgcgtgaaa gcatccctgt cagagttctt agttatgtgt ttttagtcat tgctgttgtc       60

gtgtccattt accctattta ttggttatac gtcgcatcaa ccttgtctga tggtcagatt      120

tttcactttc cacctgctaa ttggtttggg ggtcatctcc tgcaaaatgt gcgtatgctc      180

gagtccacaa tgcctgtgtg gagggacctg gcaaatagta ttgtagtctc aggtattact      240

acgattagcg tggtgttttt ctccgcaatg gtgggcttcg cgtttgcgaa gtaccgtttt      300

tgggcgaaat cttttctatt ctttgtagtg ctaatcacta tcatgatacc tatgcaaacg      360

acactcattc ctctattcat tattgtgact aaattacact gggagaatac ttaccaaggt      420

ttgatagttc cctttcttgt aaatggattc ggtgtcttct tcatgaggca gcaaatgcaa      480

tcattcccct ccgaattgct tgaggcctcg aggatagacg gggccagcga gttttatacg      540

ttctttcgaa ttgtaatgcc aaacatgctg ccctctatgg cagcgttggg catcctcaca      600

tttctacaac aatggggcaa ttttatctgg ccgttgattg taattaatag cagaaacatg      660

tcgaccgttc cgcttatgct cgagcaactt gaccaaccgg gaaatgtcat acattacggt      720

ccaatttttg ctggagcggc tatcggtcta gtaccactga tgatagtctt tgttgctttg      780

cagagatatt ttatatcggg tatgtacagt ggttctgtaa agggatga                   828


<210>   680
<211>   828
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 665

<400>   680
gtgcgtgaaa gcatccctgt cagagttctt agttatgtgt ttttagtcat tgctgttgtc       60

gtgtccattt accctattta ttggatatac gtcgcatcaa ccttgtctga tggtcagatt      120

tttcactttc cacctgctaa ttggtttggg ggtcatctcc tgcaaaatgt gcgtatgctc      180

gagtccacaa tgcctgtgtg gagggacctg gcaaatagta ttgtagtctc aggtattact      240

acgattagcg tggtgttttt ctccgcaatg gtgggcttcg cgtttgcgaa gtaccgtttt      300

tgggcgaaat cttttctatt ctttgtagtg ctaatcacta tcatgatacc tatgcaaacg      360

acactcattc ctctattcat tattgtgact aaattacact gggagaatac ttaccaaggt      420

ttgatagttc cctttcttgt aaatggattc ggtgtcttct tcatgaggca gcaaatgcaa      480

tcattcccct ccgaattgct tgaggcctcg aggatagacg gggccagcga gttttatacg      540

ttctttcgaa ttgtaatgcc acaaatgctg ccctctatgg cagcgttggg catcctcaca      600

tttctacaac aatggggcaa ttttatctgg ccgttgattg taattaatag cagaaacatg      660

tcgaccgttc cgcttatgct cgagcaactt gaccaaccgg gaaatgtcat acattacggt      720

ccaatttttg ctggagcggc tatcggtcta gtaccactga tgatagtctt tgttgctttg      780

cagagatatt ttatatcggg tatgtacagt ggttctgtaa agggatga                   828


<210>   681
<211>   349
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   681
Met Lys Arg Phe Asn Trp Lys Ser Gly Lys Lys Tyr Ala Ala Val Ala 
                5                   10                  15      

Ala Ala Ala Ala Ser Ile Val Leu Ala Ala Thr Gly Cys Ser Thr Gly 
            20                  25                  30          

Gly Gly Asn Ser Ser Thr Ser Ser Gly Ser Thr Gly Gly Ser Ser Ser 
        35                  40                  45              

Ala Phe Gln Gly Ser Ser Ser Glu Thr Tyr Tyr Met Val Thr Phe Leu 
    50                  55                  60                  

Ser Gly Ile Glu Tyr Trp Lys Gly Cys Phe Ala Gly Met Gln Ala Ala 
65                  70                  75                  80  

Ala Lys Asp Leu Gly Val Lys Ala Val Phe Thr Gly Ala Pro Gln Tyr 
                85                  90                  95      

Asp Ile Asn Gln Glu Val Thr Thr Met Gln Gln Val Ile Ala Lys His 
            100                 105                 110         

Pro Ala Gly Ile Leu Val Thr Ser Ile Asn Ala Gln Ala Met Thr Pro 
        115                 120                 125             

Val Ile Asn Gln Ala Ile Ala Ala Gly Ile Pro Val Ile Ser Phe Asp 
    130                 135                 140                 

Ser Asp Ala Pro Gln Ser Lys Arg Tyr Ala Tyr Leu Gly Thr Ser Asn 
145                 150                 155                 160 

Ile Glu Ala Gly Gln Lys Ala Ala Asp Tyr Leu Gly Gln Ala Leu Gly 
                165                 170                 175     

Gly His Gly Glu Val Ala Val Ile Thr Thr Pro Gly Glu Leu Asn Leu 
            180                 185                 190         

Asp Gln Arg Val Gln Gly Phe Lys Asp Glu Met Ala Ala Lys Tyr Pro 
        195                 200                 205             

Gly Val Lys Val Val Ala Val Gln Asn Gly Asn Ser Asp Gln Ile Lys 
    210                 215                 220                 

Thr Ala Gln Val Thr Ser Ala Leu Leu Gln Thr Tyr Pro Asn Leu Ala 
225                 230                 235                 240 

Gly Ile Phe Cys Thr Glu Ala Asp Glu Gly Thr Gly Ala Ala Thr Ala 
                245                 250                 255     

Val Gln Glu Ala Gly Lys Thr Gly Thr Val Lys Ile Val Ser Phe Asp 
            260                 265                 270         

Thr Asp Lys Ala Thr Leu Asn Ala Ile Lys Ser Gly Gln Ile Thr Ala 
        275                 280                 285             

Thr Val Ala Gln Gly Thr Trp Asn Met Gly Phe Trp Gly Leu Met Asp 
    290                 295                 300                 

Leu Phe Ala Ile His His Asn Leu Val His Pro Val Ala Asn Trp Gln 
305                 310                 315                 320 

Gln Ser Gly Val Asp Pro Val Pro Pro Glu Val Asp Thr Gly Val Thr 
                325                 330                 335     

Ile Val Thr Lys Ser Asn Val Asn Ala Tyr Leu Gln Gln 
            340                 345                 

<210>   682
<211>   1050
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   682
atgaaacggt tcaactggaa atcgggaaag aaatacgcgg cggttgcggc agctgctgcg       60

tcgatcgtct tggctgcgac gggttgctcg acaggcggcg gaaactcgtc cacttcgtcc      120

ggttcgacgg gtggcagctc ctcagcgttc cagggttcat cgagcgaaac gtactacatg      180

gtgacgttct tgtcaggtat cgagtactgg aagggatgct tcgccggcat gcaggcagcc      240

gccaaagacc ttggcgtgaa ggcggtattt actggagctc ctcagtatga tatcaaccaa      300

gaagttacga ccatgcaaca ggtcatcgcg aaacatcccg cgggtattct ggtaacgtct      360

atcaacgctc aggctatgac gcctgtcatc aaccaagcca ttgcggcagg tattcctgtc      420

attagcttcg actcggacgc gcctcaaagc aagcggtacg cgtacctcgg aaccagcaac      480

atcgaagcgg ggcagaaggc cgcggattat ctgggacaag ctctcggtgg tcacggcgaa      540

gtggcagtca tcaccacgcc gggagagctg aacttggacc aacgcgtaca gggcttcaaa      600

gacgaaatgg ccgcgaagta tccgggggtc aaagtcgtcg ccgtccagaa cggcaactct      660

gatcaaatca aaaccgctca agtcacgtct gcgttgctgc agacctatcc aaatcttgcg      720

ggtatcttct gcaccgaggc cgacgaaggt accggcgctg cgaccgccgt gcaggaggca      780

ggaaagacag gcacggtgaa gattgtctcg ttcgatacag acaaggcgac gctgaacgcg      840

atcaagagcg gacaaatcac tgccactgtc gcgcagggca catggaacat gggcttctgg      900

ggcctcatgg atttgtttgc gattcatcac aaccttgtgc atcctgtcgc caattggcag      960

cagtccggtg ttgatcccgt accgcctgaa gtggatactg gcgtgacgat cgtgacgaag     1020

agcaacgtga atgcgtactt gcaacaataa                                      1050


<210>   683
<211>   289
<212>   PRT
<213>   Caldicellulosiruptor saccharolyticus DSM 8903

<400>   683
Tyr Tyr Met Val Thr Phe Ala Ser Gly Ile Glu Tyr Trp Lys Gly Cys 
                5                   10                  15      

Phe Lys Gly Met Lys Ala Ala Ala Asp Leu Tyr Gly Val Lys Ala Ile 
            20                  25                  30          

Tyr Thr Gly Ala Pro Gln Phe Asp Val Asn Gln Gln Val Thr Val Leu 
        35                  40                  45              

Arg Gln Val Ile Ala Lys Lys Pro Ala Gly Ile Leu Val Thr Cys Ala 
    50                  55                  60                  

Asn Pro Asp Ala Leu Lys Ala Pro Ile Asp Glu Ala Ile Lys Lys Gly 
65                  70                  75                  80  

Ile Pro Val Ile Thr Phe Asp Ala Asp Ser Pro Lys Ser Leu Arg Tyr 
                85                  90                  95      

Ser Val Leu Glu Thr Gly Asn Tyr Asn Ala Gly Ala Met Ala Ala Arg 
            100                 105                 110         

Tyr Leu Gly Lys Leu Leu Gly Gly Lys Gly Glu Val Gly Ile Ser Thr 
        115                 120                 125             

Val Ala Ala Gln Leu Asn His Glu Gln Arg Lys Gln Gly Phe Ile Asp 
    130                 135                 140                 

Thr Leu Lys Lys Glu Phe Pro Gly Ile Lys Val Val Ser Ile Val Asn 
145                 150                 155                 160 

Asp Glu Asn Asp Ser Thr Lys Ala Ala Arg Gly Val Ala Ala Met Leu 
                165                 170                 175     

Gln Ala His Pro Asn Ile Lys Gly Ile Phe Cys Thr Asp Ala Pro Gly 
            180                 185                 190         

Gly Val Gly Val Ala Thr Ala Ile Lys Glu Ala Asn Lys Val Gly Lys 
        195                 200                 205             

Ile Lys Ile Val Ser Phe Asp Thr Asp Lys Gly Thr Leu Asp Leu Ile 
    210                 215                 220                 

Lys Gln Gly Val Ile Asp Ala Ser Ile Ala Gln Gly Thr Trp Asn Met 
225                 230                 235                 240 

Gly Phe Trp Gly Met Thr Phe Leu Phe Tyr Leu Lys His Gly Ile Val 
                245                 250                 255     

Asn Pro Val Asp Asn Trp Lys Lys Phe Gly Ile Asn Pro Leu Pro Pro 
            260                 265                 270         

Tyr Val Asp Thr Gly Thr Met Val Val Thr Lys Gln Asn Val Asp Ala 
        275                 280                 285             

Phe 
    

<210>   684
<211>   288
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   684
Tyr Met Met Ile Thr Phe Gln Ser Gly Met Asp Tyr Trp Lys Arg Cys 
                5                   10                  15      

Leu Lys Gly Phe Glu Asp Ala Ala Gln Ala Leu Asn Val Thr Val Glu 
            20                  25                  30          

Tyr Arg Gly Ala Ala Gln Tyr Asp Ile Gln Glu Gln Ile Thr Val Leu 
        35                  40                  45              

Glu Gln Ala Ile Ala Lys Asn Pro Ala Gly Ile Ala Ile Ser Ala Ile 
    50                  55                  60                  

Asp Pro Val Glu Leu Thr Asp Thr Ile Asn Lys Ala Val Asp Ala Gly 
65                  70                  75                  80  

Ile Pro Ile Val Leu Phe Asp Ser Gly Ala Pro Asp Ser His Ala His 
                85                  90                  95      

Ser Phe Leu Gly Thr Asn Asn Tyr Asn Ala Gly Met Asn Ala Ala Tyr 
            100                 105                 110         

Lys Met Ala Glu Leu Leu Asp Gly Glu Gly Glu Val Ala Val Ile Thr 
        115                 120                 125             

Leu Pro Asn Gln Leu Asn His Gln Glu Arg Thr Thr Gly Phe Lys Glu 
    130                 135                 140                 

Thr Leu Glu Ala Glu Phe Pro Ala Ile Glu Val Ile Ala Val Glu Asp 
145                 150                 155                 160 

Gly Arg Gly Asp Ser Leu His Ser Arg Arg Val Ala His Gln Leu Leu 
                165                 170                 175     

Glu Asp Tyr Pro Asn Leu Ala Gly Ile Phe Ala Thr Glu Ala Asn Gly 
            180                 185                 190         

Gly Val Gly Val Gly Asp Ala Val Arg Leu Glu Ser Arg Ala Gly Glu 
        195                 200                 205             

Ile Gln Ile Ile Ser Phe Asp Thr Asp Lys Gly Thr Leu Asp Leu Val 
    210                 215                 220                 

Asp Glu Gly Ile Ile Ser Ala Thr Leu Ala Gln Gly Thr Trp Asn Met 
225                 230                 235                 240 

Gly Tyr Trp Ser Leu Thr Tyr Leu Phe His Leu His His Gly Leu Thr 
                245                 250                 255     

Glu Pro Gln Ile Leu Gln Thr Arg Glu Glu Ala Pro Leu Pro Leu Tyr 
            260                 265                 270         

Val Asp Thr Gly Ile Thr Ile Val Thr Asp Glu Asn Val Asp Tyr Tyr 
        275                 280                 285             

<210>   685
<211>   284
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   685
Tyr Val Met Val Thr Phe Gln Ser Gly Met Asp Tyr Trp Lys Arg Cys 
                5                   10                  15      

Leu Lys Gly Phe Glu Asp Ala Ala Glu Ala Leu Asn Val Ser Val Glu 
            20                  25                  30          

Tyr Arg Gly Ala Thr Gln Tyr Asp Val Asn Glu Gln Val Thr Val Leu 
        35                  40                  45              

Glu Gln Val Ile Ala Arg Lys Pro Ala Gly Ile Ala Val Ser Ala Ile 
    50                  55                  60                  

Asn Pro Thr Ala Leu Thr Lys Thr Ile Asn Lys Ala Val Glu Glu Gly 
65                  70                  75                  80  

Ile Pro Val Val Leu Phe Asp Ser Asn Ala Ser Gly Ser Lys Ala Phe 
                85                  90                  95      

Ser Phe Leu Gly Thr Asn Asn Tyr Ser Ala Gly Val Thr Ala Ala His 
            100                 105                 110         

Glu Met Ala Lys Leu Leu Lys Asn Glu Gly Lys Val Ala Ile Ile Thr 
        115                 120                 125             

Ser Pro His Gln Leu Asn His Gln Glu Arg Thr Arg Gly Phe Val Glu 
    130                 135                 140                 

Thr Ile Tyr Gln Lys Tyr Pro Arg Met Gln Val Val Ala Val Lys Asn 
145                 150                 155                 160 

Gly Lys Gly Asp Ala Met Ala Ser Lys Gln Ala Ala Met Glu Ile Leu 
                165                 170                 175     

Lys Asp Tyr Pro Asp Val Gln Gly Ile Phe Ala Thr Glu Ala Asn Gly 
            180                 185                 190         

Gly Val Gly Met Ala Glu Ala Val Lys Glu Leu Asn Lys Lys Glu Ile 
        195                 200                 205             

Lys Leu Ile Ser Phe Asp Thr Glu Lys Gln Thr Leu Asp Leu Val Lys 
    210                 215                 220                 

Gly Gly Val Ile Ala Ala Thr Leu Ala Gln Gly Thr Trp Asn Met Gly 
225                 230                 235                 240 

Tyr Trp Ser Leu Gln Phe Leu Phe His Leu His His His Leu Thr Ser 
                245                 250                 255     

Pro Ser Arg Ser Gly Asp Ser Pro Leu Pro Thr Tyr Val Asp Thr Gly 
            260                 265                 270         

Ile Thr Val Val Thr Arg Glu Asn Val Asp His Phe 
        275                 280                 

<210>   686
<211>   284
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   686
Tyr Val Met Ile Thr Phe Gln Ser Gly Met Asp Tyr Trp Lys Arg Cys 
                5                   10                  15      

Leu Lys Gly Phe Glu Asp Ala Ala Glu Glu Leu Asn Val Ser Val Glu 
            20                  25                  30          

Tyr Arg Gly Ala Thr Gln Tyr Asp Val Asn Glu Gln Val Thr Val Leu 
        35                  40                  45              

Glu Gln Val Ile Ala Arg Lys Pro Ala Gly Ile Ala Ile Ser Ala Ile 
    50                  55                  60                  

Asn Pro Thr Ala Leu Thr Lys Thr Ile Asn Lys Ala Val Glu Lys Gly 
65                  70                  75                  80  

Ile Pro Val Val Leu Phe Asp Ser Asn Ala Ser Gly Ser Lys Ala Phe 
                85                  90                  95      

Ser Phe Leu Gly Thr Asn Asn Tyr Asn Ala Gly Val Thr Ala Ala His 
            100                 105                 110         

Glu Met Ala Lys Leu Leu Gly Asn Lys Gly Asn Val Gly Ile Ile Thr 
        115                 120                 125             

Ser Pro Tyr Gln Leu Asn His Gln Glu Arg Thr Arg Gly Phe Val Glu 
    130                 135                 140                 

Thr Ile Tyr Gln Lys Tyr Pro Gln Met His Val Val Ala Val Lys Asn 
145                 150                 155                 160 

Gly Lys Gly Asp Val Arg Ala Ser Lys Gln Ala Ala Ile Glu Ile Leu 
                165                 170                 175     

Lys Asp Tyr Pro Asp Val Gln Gly Ile Phe Ala Thr Glu Ala Asn Gly 
            180                 185                 190         

Gly Val Gly Met Ala Glu Ala Val Val Met Leu Asn Lys Lys His Val 
        195                 200                 205             

Lys Leu Ile Ser Phe Asp Thr Glu Lys Gln Thr Leu Asp Leu Val Lys 
    210                 215                 220                 

Lys Gly Val Ile Ala Ala Thr Leu Ala Gln Gly Thr Trp Asn Met Gly 
225                 230                 235                 240 

Tyr Trp Ser Leu Gln Phe Leu Phe Gln Leu His His Arg Leu Thr Ser 
                245                 250                 255     

Ser Ser Arg Ser Gly Asp Leu Pro Leu Pro Val Tyr Val Asp Thr Gly 
            260                 265                 270         

Ile Thr Val Val Thr Lys Glu Asn Val Asp Arg Phe 
        275                 280                 

<210>   687
<211>   280
<212>   PRT
<213>   Bacillus licheniformis ATCC 14580

<400>   687
Tyr Val Met Val Thr Phe Gln Ser Gly Ile Glu Tyr Trp Lys Ser Gly 
                5                   10                  15      

Leu Lys Gly Phe Glu Asp Ala Ala Gln Leu Phe Asn Val Ser Val Glu 
            20                  25                  30          

Tyr Arg Gly Ala Ala His Tyr Asp Val His Glu Gln Thr Thr Val Leu 
        35                  40                  45              

Glu Gln Val Ile Ala Lys Lys Pro Ala Gly Ile Ala Val Ser Ala Ile 
    50                  55                  60                  

Asn Pro Lys Ala Leu Asn Pro Val Ile Asp Lys Ala His Glu Gln Gly 
65                  70                  75                  80  

Ile Pro Ile Val Leu Phe Asp Ser Asp Ala Pro Leu Ser Lys Ala Ser 
                85                  90                  95      

Thr Tyr Ile Gly Thr Asn Asn Met Glu Ala Gly Ala Val Ala Ala Arg 
            100                 105                 110         

Arg Met Ala Glu Phe Leu Asn Gly Lys Gly Glu Thr Ala Val Ile Thr 
        115                 120                 125             

Gln Pro Gln Gln Tyr Asn His Gln Glu Arg Thr Lys Gly Phe Glu Gln 
    130                 135                 140                 

Thr Ile Lys Gln Lys Tyr Pro Asn Met Lys Val Ala Ala Val Leu Asp 
145                 150                 155                 160 

Gly Lys Gly Asp Glu Leu Thr Ser Lys Lys Glu Ala Ala Lys Ile Leu 
                165                 170                 175     

Glu Glu Asn Pro Ser Ile Lys Gly Ile Phe Thr Thr Glu Ala Asn Gly 
            180                 185                 190         

Ala Ser Gly Val Ala Arg Ala Val Lys Glu Ala Gly Leu Glu Gly Glu 
        195                 200                 205             

Val Cys Ile Ile Gly Phe Asp Lys Asp Lys Lys Thr Leu Asp Gly Ile 
    210                 215                 220                 

Lys Asn Gly Ser Ile Ser Ala Thr Met Ser Gln Asp Thr Trp Gln Met 
225                 230                 235                 240 

Gly Tyr Trp Ser Leu His Met Leu Phe Phe Ser Asn His His Leu Lys 
                245                 250                 255     

His Glu Arg Pro Leu Pro Ala Ala Ile Asp Thr Gly Ile Thr Ile Ile 
            260                 265                 270         

Thr Lys Glu Asn Val Ala Ala Tyr 
        275                 280 

<210>   688
<211>   349
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   688
Met Lys Arg Phe Asn Trp Lys Ser Gly Lys Lys Tyr Ala Ala Val Ala 
                5                   10                  15      

Ala Ala Ala Ala Ser Ile Val Leu Ala Ala Thr Gly Cys Ser Thr Gly 
            20                  25                  30          

Gly Gly Asn Ser Ser Thr Ser Ser Gly Ser Thr Gly Gly Ser Ser Ser 
        35                  40                  45              

Ala Phe Gln Gly Ser Ser Ser Glu Thr Tyr Tyr Met Val Thr Phe Leu 
    50                  55                  60                  

Ser Gly Ile Glu Tyr Trp Lys Gly Cys Phe Ala Gly Met Gln Ala Ala 
65                  70                  75                  80  

Ala Lys Asp Leu Gly Val Lys Ala Val Phe Thr Gly Ala Pro Gln Tyr 
                85                  90                  95      

Asp Ile Asn Gln Glu Val Thr Thr Met Gln Gln Val Ile Ala Lys His 
            100                 105                 110         

Pro Ala Gly Ile Leu Val Thr Ser Ile Asn Ala Gln Ala Met Thr Pro 
        115                 120                 125             

Val Ile Asn Gln Ala Ile Ala Ala Gly Ile Pro Val Ile Ser Phe Asp 
    130                 135                 140                 

Ser Asp Ala Pro Gln Ser Lys Arg Tyr Ala Tyr Leu Gly Thr Ser Asn 
145                 150                 155                 160 

Ile Glu Ala Gly Gln Lys Ala Ala Asp Tyr Leu Gly Gln Ala Leu Gly 
                165                 170                 175     

Gly His Gly Glu Val Ala Val Ile Thr Thr Pro Gly Glu Leu Asn Leu 
            180                 185                 190         

Asp Gln Arg Val Gln Gly Phe Lys Asp Glu Met Ala Ala Lys Tyr Pro 
        195                 200                 205             

Gly Val Lys Val Val Ala Val Gln Asn Gly Asn Ser Asp Gln Ile Lys 
    210                 215                 220                 

Thr Ala Gln Ile Thr Ser Ala Leu Leu Gln Thr Tyr Pro Asn Leu Ala 
225                 230                 235                 240 

Gly Ile Phe Cys Thr Glu Ala Asp Glu Gly Thr Gly Ala Ala Thr Ala 
                245                 250                 255     

Val Gln Glu Ala Gly Lys Thr Gly Thr Val Lys Ile Val Ser Phe Asp 
            260                 265                 270         

Thr Asp Lys Ala Thr Leu Asn Ala Ile Lys Ser Gly Gln Ile Thr Ala 
        275                 280                 285             

Thr Val Ala Gln Gly Thr Trp Asn Met Gly Phe Trp Gly Leu Met Asp 
    290                 295                 300                 

Leu Phe Ala Ile His His Asn Leu Val His Pro Val Ala Asn Trp Gln 
305                 310                 315                 320 

Gln Ser Gly Val Asp Pro Val Pro Pro Glu Val Asp Thr Gly Val Thr 
                325                 330                 335     

Ile Val Thr Lys Ser Asn Val Asn Ala Tyr Leu Gln Gln 
            340                 345                 

<210>   689
<211>   349
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   689
Met Lys Arg Phe Asn Trp Lys Ser Gly Lys Lys Tyr Ala Ala Val Ala 
                5                   10                  15      

Ala Ala Ala Ala Ser Ile Val Leu Ala Ala Thr Gly Cys Ser Thr Gly 
            20                  25                  30          

Gly Gly Asn Ser Ser Thr Ser Ser Gly Ser Thr Gly Gly Ser Ser Ser 
        35                  40                  45              

Ala Phe Gln Gly Ser Ser Ser Glu Thr Tyr Tyr Met Val Thr Phe Leu 
    50                  55                  60                  

Ser Gly Ile Glu Tyr Trp Lys Gly Cys Phe Ala Gly Met Gln Ala Ala 
65                  70                  75                  80  

Ala Lys Asp Leu Gly Val Lys Ala Val Phe Thr Gly Ala Pro Gln Tyr 
                85                  90                  95      

Asp Ile Asn Gln Glu Val Thr Thr Met Gln Gln Val Ile Ala Lys His 
            100                 105                 110         

Pro Ala Gly Ile Leu Val Thr Ser Ile Asn Ala Gln Ala Met Thr Pro 
        115                 120                 125             

Val Ile Asn Gln Ala Ile Ala Ala Gly Ile Pro Val Ile Ser Phe Asp 
    130                 135                 140                 

Ser Asp Ala Pro Gln Ser Lys Arg Tyr Ala Tyr Leu Gly Thr Ser Asn 
145                 150                 155                 160 

Ile Glu Ala Gly Gln Lys Ala Ala Asp Tyr Leu Gly Gln Ala Leu Gly 
                165                 170                 175     

Gly His Gly Glu Val Ala Val Ile Thr Thr Pro Gly Glu Leu Asn Leu 
            180                 185                 190         

Asp Gln Arg Val Gln Gly Phe Lys Asp Glu Met Ala Ala Lys Tyr Pro 
        195                 200                 205             

Gly Val Lys Val Val Ala Val Gln Asn Gly Asn Ser Asp Gln Ile Lys 
    210                 215                 220                 

Thr Ala Gln Val Thr Ser Ala Leu Leu Gln Thr Tyr Pro Asn Leu Ala 
225                 230                 235                 240 

Gly Ile Phe Cys Thr Glu Ala Asp Glu Gly Thr Gly Ala Ala Thr Ala 
                245                 250                 255     

Val Gln Glu Ala Gly Lys Thr Gly Thr Val Arg Ile Val Ser Phe Asp 
            260                 265                 270         

Thr Asp Lys Ala Thr Leu Asn Ala Ile Lys Ser Gly Gln Ile Thr Ala 
        275                 280                 285             

Thr Val Ala Gln Gly Thr Trp Asn Met Gly Phe Trp Gly Leu Met Asp 
    290                 295                 300                 

Leu Phe Ala Ile His His Asn Leu Val His Pro Val Ala Asn Trp Gln 
305                 310                 315                 320 

Gln Ser Gly Val Asp Pro Val Pro Pro Glu Val Asp Thr Gly Val Thr 
                325                 330                 335     

Ile Val Thr Lys Ser Asn Val Asn Ala Tyr Leu Gln Gln 
            340                 345                 

<210>   690
<211>   349
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   690
Met Lys Arg Phe Asn Trp Lys Ser Gly Lys Lys Tyr Ala Ala Val Ala 
                5                   10                  15      

Ala Ala Ala Ala Ser Ile Val Leu Ala Ala Thr Gly Cys Ser Thr Gly 
            20                  25                  30          

Gly Gly Asn Ser Ser Thr Ser Ser Gly Ser Thr Gly Gly Ser Ser Ser 
        35                  40                  45              

Ala Phe Gln Gly Ser Ser Ser Glu Thr Tyr Tyr Met Val Thr Phe Leu 
    50                  55                  60                  

Ser Gly Ile Asp Tyr Trp Lys Gly Cys Phe Ala Gly Met Gln Ala Ala 
65                  70                  75                  80  

Ala Lys Asp Leu Gly Val Lys Ala Val Phe Thr Gly Ala Pro Gln Tyr 
                85                  90                  95      

Asp Ile Asn Gln Glu Val Thr Thr Met Gln Gln Val Ile Ala Lys His 
            100                 105                 110         

Pro Ala Gly Ile Leu Val Thr Ser Ile Asn Ala Gln Ala Met Thr Pro 
        115                 120                 125             

Val Ile Asn Gln Ala Ile Ala Ala Gly Ile Pro Val Ile Ser Phe Asp 
    130                 135                 140                 

Ser Asp Ala Pro Gln Ser Lys Arg Tyr Ala Tyr Leu Gly Thr Ser Asn 
145                 150                 155                 160 

Ile Glu Ala Gly Gln Lys Ala Ala Asp Tyr Leu Gly Gln Ala Leu Gly 
                165                 170                 175     

Gly His Gly Glu Val Ala Val Ile Thr Thr Pro Gly Glu Leu Asn Leu 
            180                 185                 190         

Asp Gln Arg Val Gln Gly Phe Lys Asp Glu Met Ala Ala Lys Tyr Pro 
        195                 200                 205             

Gly Val Lys Val Val Ala Val Gln Asn Gly Asn Ser Asp Gln Ile Lys 
    210                 215                 220                 

Thr Ala Gln Val Thr Ser Ala Leu Leu Gln Thr Tyr Pro Asn Leu Ala 
225                 230                 235                 240 

Gly Ile Phe Cys Thr Glu Ala Asp Glu Gly Thr Gly Ala Ala Thr Ala 
                245                 250                 255     

Val Gln Glu Ala Gly Lys Thr Gly Thr Val Lys Ile Val Ser Phe Asp 
            260                 265                 270         

Thr Asp Lys Ala Thr Leu Asn Ala Ile Lys Ser Gly Gln Ile Thr Ala 
        275                 280                 285             

Thr Val Ala Gln Gly Thr Trp Asn Met Gly Phe Trp Gly Leu Met Asp 
    290                 295                 300                 

Leu Phe Ala Ile His His Asn Leu Val His Pro Val Ala Asn Trp Gln 
305                 310                 315                 320 

Gln Ser Gly Val Asp Pro Val Pro Pro Glu Val Asp Thr Gly Val Thr 
                325                 330                 335     

Ile Val Thr Lys Ser Asn Val Asn Ala Tyr Leu Gln Gln 
            340                 345                 

<210>   691
<211>   349
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   691
Met Lys Arg Phe Asn Trp Lys Ser Gly Lys Lys Tyr Ala Ala Val Ala 
                5                   10                  15      

Ala Ala Ala Ala Ser Ile Val Leu Ala Ala Thr Gly Cys Ser Thr Gly 
            20                  25                  30          

Gly Gly Asn Ser Ser Thr Ser Ser Gly Ser Thr Gly Gly Ser Ser Ser 
        35                  40                  45              

Ala Phe Gln Gly Ser Ser Ser Glu Thr Tyr Tyr Met Val Thr Phe Leu 
    50                  55                  60                  

Ser Gly Ile Glu Tyr Trp Lys Gly Cys Phe Ala Gly Met Gln Ala Ala 
65                  70                  75                  80  

Ala Lys Asp Leu Gly Val Lys Ala Val Phe Thr Gly Ala Pro Gln Tyr 
                85                  90                  95      

Asp Ile Asn Gln Glu Val Thr Thr Met Gln Gln Val Ile Ala Lys His 
            100                 105                 110         

Pro Ala Gly Ile Leu Val Thr Ser Ile Asn Ala Gln Ala Met Thr Pro 
        115                 120                 125             

Val Ile Asn Gln Ala Ile Ala Ala Gly Ile Pro Val Ile Ser Phe Asp 
    130                 135                 140                 

Ser Asp Ala Pro Gln Ser Lys Arg Tyr Ala Tyr Leu Gly Thr Ser Asn 
145                 150                 155                 160 

Ile Glu Ala Gly Gln Lys Ala Ala Asp Tyr Leu Gly Asn Ala Leu Gly 
                165                 170                 175     

Gly His Gly Glu Val Ala Val Ile Thr Thr Pro Gly Glu Leu Asn Leu 
            180                 185                 190         

Asp Gln Arg Val Gln Gly Phe Lys Asp Glu Met Ala Ala Lys Tyr Pro 
        195                 200                 205             

Gly Val Lys Val Val Ala Val Gln Asn Gly Asn Ser Asp Gln Ile Lys 
    210                 215                 220                 

Thr Ala Gln Val Thr Ser Ala Leu Leu Gln Thr Tyr Pro Asn Leu Ala 
225                 230                 235                 240 

Gly Ile Phe Cys Thr Glu Ala Asp Glu Gly Thr Gly Ala Ala Thr Ala 
                245                 250                 255     

Val Gln Glu Ala Gly Lys Thr Gly Thr Val Lys Ile Val Ser Phe Asp 
            260                 265                 270         

Thr Asp Lys Ala Thr Leu Asn Ala Ile Lys Ser Gly Gln Ile Thr Ala 
        275                 280                 285             

Thr Val Ala Gln Gly Thr Trp Asn Met Gly Phe Trp Gly Leu Met Asp 
    290                 295                 300                 

Leu Phe Ala Ile His His Asn Leu Val His Pro Val Ala Asn Trp Gln 
305                 310                 315                 320 

Gln Ser Gly Val Asp Pro Val Pro Pro Glu Val Asp Thr Gly Val Thr 
                325                 330                 335     

Ile Val Thr Lys Ser Asn Val Asn Ala Tyr Leu Gln Gln 
            340                 345                 

<210>   692
<211>   349
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 681

<400>   692
Met Lys Arg Phe Asn Trp Lys Ser Gly Lys Lys Tyr Ala Ala Val Ala 
                5                   10                  15      

Ala Ala Ala Ala Ser Ile Val Leu Ala Ala Thr Gly Cys Ser Thr Gly 
            20                  25                  30          

Gly Gly Asn Ser Ser Thr Ser Ser Gly Ser Thr Gly Gly Ser Ser Ser 
        35                  40                  45              

Ala Phe Gln Gly Ser Ser Ser Glu Thr Tyr Tyr Met Val Thr Phe Leu 
    50                  55                  60                  

Ser Gly Ile Glu Tyr Trp Lys Gly Cys Phe Ala Gly Met Gln Ala Ala 
65                  70                  75                  80  

Ala Lys Asp Leu Gly Val Lys Ala Val Phe Thr Gly Ala Pro Gln Tyr 
                85                  90                  95      

Asp Ile Asn Gln Glu Val Thr Thr Met Gln Gln Val Ile Ala Lys His 
            100                 105                 110         

Pro Ala Gly Ile Leu Val Thr Ser Ile Asn Ala Gln Ala Met Thr Pro 
        115                 120                 125             

Val Ile Asn Gln Ala Ile Ala Ala Gly Ile Pro Val Ile Ser Phe Asp 
    130                 135                 140                 

Ser Asp Ala Pro Gln Ser Lys Arg Tyr Ala Tyr Leu Gly Thr Ser Asn 
145                 150                 155                 160 

Ile Glu Ala Gly Gln Lys Ala Ala Asp Tyr Leu Gly Gln Ala Leu Gly 
                165                 170                 175     

Gly His Gly Glu Val Ala Val Ile Thr Thr Pro Gly Glu Leu Asn Leu 
            180                 185                 190         

Asp Gln Arg Val Gln Gly Phe Lys Asp Glu Met Ala Ala Lys Tyr Pro 
        195                 200                 205             

Gly Val Lys Val Val Ala Val Gln Asn Gly Asn Ser Asp Gln Ile Lys 
    210                 215                 220                 

Thr Ala Gln Val Thr Ser Ala Leu Leu Gln Thr Tyr Pro Asn Leu Ala 
225                 230                 235                 240 

Gly Ile Phe Cys Thr Glu Ala Asp Glu Gly Thr Gly Ala Ala Thr Ala 
                245                 250                 255     

Val Gln Glu Ala Gly Lys Thr Gly Thr Val Lys Ile Val Ser Phe Asp 
            260                 265                 270         

Thr Asp Lys Ala Thr Leu Asn Ala Ile Lys Ser Gly Gln Ile Thr Ala 
        275                 280                 285             

Thr Val Ala Gln Gly Thr Trp Asn Met Gly Phe Trp Gly Leu Met Asp 
    290                 295                 300                 

Leu Phe Ala Leu His His Asn Leu Val His Pro Val Ala Asn Trp Gln 
305                 310                 315                 320 

Gln Ser Gly Val Asp Pro Val Pro Pro Glu Val Asp Thr Gly Val Thr 
                325                 330                 335     

Ile Val Thr Lys Ser Asn Val Asn Ala Tyr Leu Gln Gln 
            340                 345                 

<210>   693
<211>   1050
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   693
atgaaacggt tcaactggaa atcgggaaag aaatacgcgg cggttgcggc agctgctgcg       60

tcgatcgtct tggctgcgac gggttgctcg acaggcggcg gaaactcgtc cacttcgtcc      120

ggttcgacgg gtggcagctc ctcagcgttc cagggttcat cgagcgaaac gtactacatg      180

gtgacgttct tgtcaggtat cgagtactgg aagggatgct tcgccggcat gcaggcagcc      240

gccaaagacc ttggcgtgaa ggcggtattt actggagctc ctcagtatga tatcaaccaa      300

gaagttacga ccatgcaaca ggtcatcgcg aaacatcccg cgggtattct ggtaacgtct      360

atcaacgctc aggctatgac gcctgtcatc aaccaagcca ttgcggcagg tattcctgtc      420

attagcttcg actcggacgc gcctcaaagc aagcggtacg cgtacctcgg aaccagcaac      480

atcgaagcgg ggcagaaggc cgcggattat ctgggacaag ctctcggtgg tcacggcgaa      540

gtggcagtca tcaccacgcc gggagagctg aacttggacc aacgcgtaca gggcttcaaa      600

gacgaaatgg ccgcgaagta tccgggggtc aaagtcgtcg ccgtccagaa cggcaactct      660

gatcaaatca aaaccgctca aattacgtct gcgttgctgc agacctatcc aaatcttgcg      720

ggtatcttct gcaccgaggc cgacgaaggt accggcgctg cgaccgccgt gcaggaggca      780

ggaaagacag gcacggtgaa gattgtctcg ttcgatacag acaaggcgac gctgaacgcg      840

atcaagagcg gacaaatcac tgccactgtc gcgcagggca catggaacat gggcttctgg      900

ggcctcatgg atttgtttgc gattcatcac aaccttgtgc atcctgtcgc caattggcag      960

cagtccggtg ttgatcccgt accgcctgaa gtggatactg gcgtgacgat cgtgacgaag     1020

agcaacgtga atgcgtactt gcaacaataa                                      1050


<210>   694
<211>   1050
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   694
atgaaacggt tcaactggaa atcgggaaag aaatacgcgg cggttgcggc agctgctgcg       60

tcgatcgtct tggctgcgac gggttgctcg acaggcggcg gaaactcgtc cacttcgtcc      120

ggttcgacgg gtggcagctc ctcagcgttc cagggttcat cgagcgaaac gtactacatg      180

gtgacgttct tgtcaggtat cgagtactgg aagggatgct tcgccggcat gcaggcagcc      240

gccaaagacc ttggcgtgaa ggcggtattt actggagctc ctcagtatga tatcaaccaa      300

gaagttacga ccatgcaaca ggtcatcgcg aaacatcccg cgggtattct ggtaacgtct      360

atcaacgctc aggctatgac gcctgtcatc aaccaagcca ttgcggcagg tattcctgtc      420

attagcttcg actcggacgc gcctcaaagc aagcggtacg cgtacctcgg aaccagcaac      480

atcgaagcgg ggcagaaggc cgcggattat ctgggacaag ctctcggtgg tcacggcgaa      540

gtggcagtca tcaccacgcc gggagagctg aacttggacc aacgcgtaca gggcttcaaa      600

gacgaaatgg ccgcgaagta tccgggggtc aaagtcgtcg ccgtccagaa cggcaactct      660

gatcaaatca aaaccgctca agtcacgtct gcgttgctgc agacctatcc aaatcttgcg      720

ggtatcttct gcaccgaggc cgacgaaggt accggcgctg cgaccgccgt gcaggaggca      780

ggaaagacag gcacggtgcg tattgtctcg ttcgatacag acaaggcgac gctgaacgcg      840

atcaagagcg gacaaatcac tgccactgtc gcgcagggca catggaacat gggcttctgg      900

ggcctcatgg atttgtttgc gattcatcac aaccttgtgc atcctgtcgc caattggcag      960

cagtccggtg ttgatcccgt accgcctgaa gtggatactg gcgtgacgat cgtgacgaag     1020

agcaacgtga atgcgtactt gcaacaataa                                      1050


<210>   695
<211>   1050
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   695
atgaaacggt tcaactggaa atcgggaaag aaatacgcgg cggttgcggc agctgctgcg       60

tcgatcgtct tggctgcgac gggttgctcg acaggcggcg gaaactcgtc cacttcgtcc      120

ggttcgacgg gtggcagctc ctcagcgttc cagggttcat cgagcgaaac gtactacatg      180

gtgacgttct tgtcaggtat cgattactgg aagggatgct tcgccggcat gcaggcagcc      240

gccaaagacc ttggcgtgaa ggcggtattt actggagctc ctcagtatga tatcaaccaa      300

gaagttacga ccatgcaaca ggtcatcgcg aaacatcccg cgggtattct ggtaacgtct      360

atcaacgctc aggctatgac gcctgtcatc aaccaagcca ttgcggcagg tattcctgtc      420

attagcttcg actcggacgc gcctcaaagc aagcggtacg cgtacctcgg aaccagcaac      480

atcgaagcgg ggcagaaggc cgcggattat ctgggacaag ctctcggtgg tcacggcgaa      540

gtggcagtca tcaccacgcc gggagagctg aacttggacc aacgcgtaca gggcttcaaa      600

gacgaaatgg ccgcgaagta tccgggggtc aaagtcgtcg ccgtccagaa cggcaactct      660

gatcaaatca aaaccgctca agtcacgtct gcgttgctgc agacctatcc aaatcttgcg      720

ggtatcttct gcaccgaggc cgacgaaggt accggcgctg cgaccgccgt gcaggaggca      780

ggaaagacag gcacggtgaa gattgtctcg ttcgatacag acaaggcgac gctgaacgcg      840

atcaagagcg gacaaatcac tgccactgtc gcgcagggca catggaacat gggcttctgg      900

ggcctcatgg atttgtttgc gattcatcac aaccttgtgc atcctgtcgc caattggcag      960

cagtccggtg ttgatcccgt accgcctgaa gtggatactg gcgtgacgat cgtgacgaag     1020

agcaacgtga atgcgtactt gcaacaataa                                      1050


<210>   696
<211>   1050
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   696
atgaaacggt tcaactggaa atcgggaaag aaatacgcgg cggttgcggc agctgctgcg       60

tcgatcgtct tggctgcgac gggttgctcg acaggcggcg gaaactcgtc cacttcgtcc      120

ggttcgacgg gtggcagctc ctcagcgttc cagggttcat cgagcgaaac gtactacatg      180

gtgacgttct tgtcaggtat cgagtactgg aagggatgct tcgccggcat gcaggcagcc      240

gccaaagacc ttggcgtgaa ggcggtattt actggagctc ctcagtatga tatcaaccaa      300

gaagttacga ccatgcaaca ggtcatcgcg aaacatcccg cgggtattct ggtaacgtct      360

atcaacgctc aggctatgac gcctgtcatc aaccaagcca ttgcggcagg tattcctgtc      420

attagcttcg actcggacgc gcctcaaagc aagcggtacg cgtacctcgg aaccagcaac      480

atcgaagcgg ggcagaaggc cgcggattat ctgggaaatg ctctcggtgg tcacggcgaa      540

gtggcagtca tcaccacgcc gggagagctg aacttggacc aacgcgtaca gggcttcaaa      600

gacgaaatgg ccgcgaagta tccgggggtc aaagtcgtcg ccgtccagaa cggcaactct      660

gatcaaatca aaaccgctca agtcacgtct gcgttgctgc agacctatcc aaatcttgcg      720

ggtatcttct gcaccgaggc cgacgaaggt accggcgctg cgaccgccgt gcaggaggca      780

ggaaagacag gcacggtgaa gattgtctcg ttcgatacag acaaggcgac gctgaacgcg      840

atcaagagcg gacaaatcac tgccactgtc gcgcagggca catggaacat gggcttctgg      900

ggcctcatgg atttgtttgc gattcatcac aaccttgtgc atcctgtcgc caattggcag      960

cagtccggtg ttgatcccgt accgcctgaa gtggatactg gcgtgacgat cgtgacgaag     1020

agcaacgtga atgcgtactt gcaacaataa                                      1050


<210>   697
<211>   1050
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 682

<400>   697
atgaaacggt tcaactggaa atcgggaaag aaatacgcgg cggttgcggc agctgctgcg       60

tcgatcgtct tggctgcgac gggttgctcg acaggcggcg gaaactcgtc cacttcgtcc      120

ggttcgacgg gtggcagctc ctcagcgttc cagggttcat cgagcgaaac gtactacatg      180

gtgacgttct tgtcaggtat cgagtactgg aagggatgct tcgccggcat gcaggcagcc      240

gccaaagacc ttggcgtgaa ggcggtattt actggagctc ctcagtatga tatcaaccaa      300

gaagttacga ccatgcaaca ggtcatcgcg aaacatcccg cgggtattct ggtaacgtct      360

atcaacgctc aggctatgac gcctgtcatc aaccaagcca ttgcggcagg tattcctgtc      420

attagcttcg actcggacgc gcctcaaagc aagcggtacg cgtacctcgg aaccagcaac      480

atcgaagcgg ggcagaaggc cgcggattat ctgggacaag ctctcggtgg tcacggcgaa      540

gtggcagtca tcaccacgcc gggagagctg aacttggacc aacgcgtaca gggcttcaaa      600

gacgaaatgg ccgcgaagta tccgggggtc aaagtcgtcg ccgtccagaa cggcaactct      660

gatcaaatca aaaccgctca agtcacgtct gcgttgctgc agacctatcc aaatcttgcg      720

ggtatcttct gcaccgaggc cgacgaaggt accggcgctg cgaccgccgt gcaggaggca      780

ggaaagacag gcacggtgaa gattgtctcg ttcgatacag acaaggcgac gctgaacgcg      840

atcaagagcg gacaaatcac tgccactgtc gcgcagggca catggaacat gggcttctgg      900

ggcctcatgg atttgtttgc gttacatcac aaccttgtgc atcctgtcgc caattggcag      960

cagtccggtg ttgatcccgt accgcctgaa gtggatactg gcgtgacgat cgtgacgaag     1020

agcaacgtga atgcgtactt gcaacaataa                                      1050


<210>   698
<211>   353
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   698
Met Thr Lys Pro Ser Trp Ser Thr His Leu Ala Cys Thr Arg Lys Leu 
                5                   10                  15      

Leu Trp Gly Glu Asn Met Gln Pro Val Asp Thr Ala Pro Val Asn Ile 
            20                  25                  30          

Asp Lys Glu Arg Glu Thr Trp Leu Arg Arg Val Ala Arg Ile Arg Glu 
        35                  40                  45              

Leu Thr Ile Val Leu Val Ile Val Ala Leu Cys Ile Ile Leu Ser Phe 
    50                  55                  60                  

Met Ser Ser Ser Phe Leu Ser Val Asp Asn Ile Val Thr Thr Ile Leu 
65                  70                  75                  80  

Ser Ile Val Met Thr Ala Ile Val Ser Val Gly Met Thr Val Ala Leu 
                85                  90                  95      

Val Ser Gly Gly Phe Asp Leu Ser Val Gly Ser Val Met Ser Met Ala 
            100                 105                 110         

Gly Val Val Thr Gly Ser Leu Ala Leu Asn Gly Val Asn Ile Trp Leu 
        115                 120                 125             

Ala Ala Ile Phe Gly Leu Leu Ala Ser Leu Cys Ser Gly Leu Ile Thr 
    130                 135                 140                 

Gly Leu Phe Ile Gly Lys Val Lys Ile Asn Pro Phe Ile Met Thr Leu 
145                 150                 155                 160 

Gly Met Gln Gly Val Val Gln Gly Val Ala Tyr Val Val Thr Gln Gly 
                165                 170                 175     

Ala Pro Leu Ser Val Thr Gly Val Pro Lys Ser Phe Leu Tyr Leu Gly 
            180                 185                 190         

Gln Gly Asn Leu Leu Gly Ile Pro Val Leu Ile Trp Ile Leu Ala Val 
        195                 200                 205             

Val Val Val Val Ser Asp Phe Ile Met Arg Arg Ala Val Val Ala Arg 
    210                 215                 220                 

Lys Val Tyr Tyr Ile Gly Ser Asn Glu Ala Ala Ala Tyr Leu Ser Gly 
225                 230                 235                 240 

Ile Arg Val Ser Lys Val Lys Val Trp Ile Tyr Ile Phe Thr Ala Leu 
                245                 250                 255     

Leu Ala Gly Ile Ala Gly Ile Leu Thr Leu Ser Arg Phe Ser Val Ala 
            260                 265                 270         

Ala Pro Thr Ala Gly Gln Gly Met Glu Leu Gln Ala Ile Ala Ala Cys 
        275                 280                 285             

Ile Ile Gly Gly Ala Ser Leu Thr Gly Gly Glu Gly Thr Val Leu Gly 
    290                 295                 300                 

Ala Leu Leu Gly Ser Val Leu Val Gly Ile Val Asn Asp Ala Leu Val 
305                 310                 315                 320 

Leu Leu Asn Val Ser Val Tyr Trp Gln Ser Leu Val Thr Gly Phe Val 
                325                 330                 335     

Leu Ile Ala Ala Val Thr Leu Asp Val Leu Thr His Arg Lys Lys Ala 
            340                 345                 350         

Asn 
    

<210>   699
<211>   1062
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   699
atgacgaaac catcatggag tacgcatctg gcttgcacaa ggaaactgct gtggggtgag       60

aacatgcaac cagtggacac cgctcccgtc aatatcgaca aagaacgcga gacgtggctt      120

cggagagtcg cgcgtattcg agaacttact attgtcctcg tgatcgtggc tctctgcatc      180

attctgtcct tcatgtcgtc gtcatttctg agtgttgata acatcgtcac gacgattttg      240

agcatcgtca tgacagccat tgtatcggtg ggcatgacag tggcactcgt gtccggaggg      300

ttcgacctct cggtcggctc cgtgatgtcc atggcaggtg tggtcacggg aagcttggca      360

ttaaatggtg tgaacatttg gctggcggcg atctttggtc tgttggccag cctgtgctcc      420

gggctgatta caggtctatt tatcggcaag gtcaagatca atccgttcat catgaccctc      480

ggtatgcagg gcgtggttca aggtgtggct tacgtcgtga cccagggtgc gccgttgtcc      540

gtcacgggtg taccgaagtc gtttctctac cttggtcagg gcaatttgct gggcattccc      600

gttctcatct ggattctggc ggtcgtggtt gttgtctccg acttcatcat gaggcgtgca      660

gtcgttgctc gtaaggtgta ctacatcggc agcaacgaag cggctgcgta cttgtctggt      720

attcgagtct ccaaggtaaa ggtttggatc tacattttca ccgctctatt ggcgggcatc      780

gcgggaattc tgacactctc gcggttcagc gtagctgcac cgaccgctgg gcagggtatg      840

gaacttcagg ccattgctgc gtgtatcatc ggcggtgcca gcttgacggg aggtgagggt      900

accgtcctcg gagcactgct cggtagcgtg ctcgtgggca tcgtaaatga tgcgttggtg      960

ctgttgaacg tatccgttta ttggcagagc cttgttacag gcttcgttct gattgctgcg     1020

gtgacgttag acgtcctgac ccacaggaaa aaggcaaatt ga                        1062


<210>   700
<211>   281
<212>   PRT
<213>   Caldicellulosiruptor saccharolyticus DSM 8903

<400>   700
Glu Asn Leu Ile Thr Thr Ala Leu Gly Leu Ala Ala Asp Gly Ile Leu 
                5                   10                  15      

Ala Ile Gly Met Thr Ile Val Leu Val Ser Gly Gly Val Asp Leu Ser 
            20                  25                  30          

Val Gly Ser Val Leu Gly Leu Ser Ala Val Ile Ala Gly Gly Leu Tyr 
        35                  40                  45              

Leu Ser Phe Gly Val Asn Ile Trp Ile Gly Ser Leu Ile Ala Leu Ile 
    50                  55                  60                  

Val Cys Ala Leu Ile Gly Leu Phe Asn Gly Tyr Phe Ile Ala Arg Val 
65                  70                  75                  80  

Gly Ile Pro Pro Leu Ile Val Thr Leu Ala Met Met Gly Ile Ala Arg 
                85                  90                  95      

Gly Ala Ala Tyr Val Leu Thr Gln Gly Ser Pro Leu Ala Leu Tyr Gly 
            100                 105                 110         

Asn Leu Lys Gly Phe Asp Phe Leu Gly Gln Gly Lys Ile Leu Gly Ile 
        115                 120                 125             

Pro Phe Phe Ile Val Phe Phe Ile Phe Leu Ile Ile Leu Phe Asp Phe 
    130                 135                 140                 

Leu Met Arg Lys Ser Ala Pro Phe Arg Leu Val Tyr Tyr Val Gly Ser 
145                 150                 155                 160 

Asn Glu Asn Ala Ala Lys Leu Ser Gly Ile Asn Val Pro Asn Val Lys 
                165                 170                 175     

Ile Ser Val Tyr Val Leu Met Ser Val Leu Ala Gly Ile Ala Gly Ile 
            180                 185                 190         

Phe Thr Leu Ser Arg Phe Ser Val Ala Ala Pro Thr Ala Gly Asn Gly 
        195                 200                 205             

Ser Glu Leu Asn Ala Ile Ser Ala Cys Val Ile Gly Gly Ala Ser Leu 
    210                 215                 220                 

Ala Gly Gly Glu Gly Thr Val Leu Gly Ala Ile Leu Gly Thr Ile Leu 
225                 230                 235                 240 

Val Gly Ile Ile Asn Asn Ala Leu Val Leu Leu Asn Val Ser Val Tyr 
                245                 250                 255     

Trp Gln Asn Leu Val Ser Gly Leu Ile Leu Ile Ala Ala Val Thr Ile 
            260                 265                 270         

Asp Tyr Leu Thr His Gln Lys Lys Ser 
        275                 280     

<210>   701
<211>   279
<212>   PRT
<213>   Clostridium thermocellum ATCC 27405

<400>   701
Asn Asn Met Arg Ser Ile Ala Leu Ser Val Ser Val Asp Gly Leu Phe 
                5                   10                  15      

Ala Ile Gly Leu Thr Met Ala Leu Ile Leu Gly Gly Ile Glu Leu Ser 
            20                  25                  30          

Val Gly Ser Val Ala Ala Met Thr Cys Val Ile Thr Gly Tyr Leu Ala 
        35                  40                  45              

Leu Gln Gly Val Asn Ile Trp Val Ala Cys Ile Ala Ser Ile Ala Ser 
    50                  55                  60                  

Gly Leu Val Val Gly Leu Phe Asn Gly Phe Met Ile Ser Lys Ile Gly 
65                  70                  75                  80  

Leu Pro Pro Phe Ile Val Thr Leu Gly Met Glu Asn Leu Ala Arg Gly 
                85                  90                  95      

Met Ala Tyr Ile Ile Thr Thr Gly Ser Pro Leu Ser Val Ser Gly Tyr 
            100                 105                 110         

Leu Pro Gln Ser Phe Arg Phe Phe Ala Thr Gly Ser Val Phe Gly Ile 
        115                 120                 125             

Pro Val Leu Phe Ile Ile Phe Ile Ile Ile Ser Ala Ile Ala Phe Ile 
    130                 135                 140                 

Phe Met Lys Tyr Ser Lys Ile Cys Arg Asn Ile Tyr Tyr Val Gly Ser 
145                 150                 155                 160 

Asn Glu Asn Ala Ala Arg Leu Ser Gly Ile Asn Val Asp Arg Val Lys 
                165                 170                 175     

Ile Gly Val Tyr Val Thr Ile Ala Leu Ile Ser Thr Leu Ala Gly Leu 
            180                 185                 190         

Leu Ser Leu Ala Arg Phe Asn Val Ala Thr Pro Glu Leu Ser Lys Gly 
        195                 200                 205             

Ala Glu Thr Thr Ala Ile Ser Ala Ala Val Ile Gly Gly Thr Ser Met 
    210                 215                 220                 

Thr Gly Gly Ser Gly Gly Val Leu Gly Thr Val Leu Gly Ile Phe Leu 
225                 230                 235                 240 

Leu Lys Ile Val Asn Ser Ala Leu Val Met Met Asn Val Ser Val Tyr 
                245                 250                 255     

Trp Gln Glu Phe Val Gln Gly Ala Ile Leu Val Leu Ala Val Thr Ile 
            260                 265                 270         

Asp Tyr Leu Ser His Arg Lys 
        275                 

<210>   702
<211>   327
<212>   PRT
<213>   Sinorhizobium medicae WSM419

<400>   702
Val Asp Ile Leu Pro Val Ala His Asp Ala Arg Arg Pro Ala Trp Lys 
                5                   10                  15      

Arg Ile Gly Thr Met Arg Glu Ala Gly Leu Ile Ala Ile Ile Leu Ser 
            20                  25                  30          

Leu Cys Val Ile Met Ser Phe Ala Ser Pro His Phe Leu Thr Leu Gly 
        35                  40                  45              

Asn Phe Arg Ala Met Leu Met Ser Phe Ser Val Glu Gly Ile Val Val 
    50                  55                  60                  

Val Gly Met Thr Ile Leu Leu Ile Val Gly Gly Ile Asp Leu Ser Val 
65                  70                  75                  80  

Gly Ser Val Val Cys Phe Ser Met Val Leu Ser Gly Ser Leu Phe Leu 
                85                  90                  95      

Met Gly Val Asp Pro Trp Thr Ala Ser Leu Val Gly Ile Ala Ala Ser 
            100                 105                 110         

Ala Ala Ile Gly Cys Ile Met Gly Phe Phe Val Thr Val Val Gly Leu 
        115                 120                 125             

Asn His Phe Ile Thr Ser Leu Ala Ala Met Val Ile Val Arg Gly Leu 
    130                 135                 140                 

Cys Leu Val Ile Thr Lys Gly Thr Pro Leu Ser Leu Phe Thr Leu Pro 
145                 150                 155                 160 

Pro Ala Phe Lys Ala Val Gly Gln Gly Thr Phe Phe Gly Val Pro Tyr 
                165                 170                 175     

Val Ile Val Ile Phe Ile Ala Val Val Ala Val Phe Asp Phe Leu Leu 
            180                 185                 190         

Arg Arg Ala Thr Ala Phe Arg Lys Val Phe Tyr Thr Gly Ser Asn Glu 
        195                 200                 205             

Lys Ala Ala Leu Tyr Ser Gly Ile Lys Thr Lys Asp Val Lys Phe Trp 
    210                 215                 220                 

Val Thr Val Leu Cys Thr Thr Leu Ser Gly Val Ala Gly Thr Ile Tyr 
225                 230                 235                 240 

Met Ala Arg Phe Gly Ala Ala Thr Pro Thr Phe Gly Val Gly Met Glu 
                245                 250                 255     

Leu Asn Ile Ile Ala Ala Ala Val Ile Gly Gly Ala Ser Leu Asn Gly 
            260                 265                 270         

Gly Ser Gly Thr Ile Leu Gly Ala Ile Leu Gly Ile Ala Leu Leu Ser 
        275                 280                 285             

Val Val Thr Ser Ser Leu Ile Leu Leu Asp Val Ser Val Tyr Trp Gln 
    290                 295                 300                 

Asp Met Ile Lys Gly Cys Ile Leu Leu Ala Ala Val Ser Ile Asp His 
305                 310                 315                 320 

Met Leu His Lys Arg Lys Ala 
                325         

<210>   703
<211>   327
<212>   PRT
<213>   Sinorhizobium meliloti 1021

<400>   703
Val Asp Thr Leu Ala Val Ala Gln Lys Thr Arg Arg Pro Thr Trp Lys 
                5                   10                  15      

Arg Ile Gly Thr Met Arg Glu Ala Gly Leu Ile Ala Ile Ile Leu Ser 
            20                  25                  30          

Leu Ser Val Ile Met Ser Phe Ala Ser Pro His Phe Leu Thr Leu Gly 
        35                  40                  45              

Asn Phe Arg Ala Met Leu Met Ser Phe Ser Val Glu Gly Ile Val Val 
    50                  55                  60                  

Val Gly Met Thr Ile Leu Leu Ile Val Gly Gly Ile Asp Leu Ser Val 
65                  70                  75                  80  

Gly Ser Val Val Cys Phe Ser Met Val Leu Ser Gly Ser Leu Phe Leu 
                85                  90                  95      

Met Gly Val Asp Pro Trp Thr Ala Ser Leu Val Gly Ile Ala Ala Ser 
            100                 105                 110         

Ala Ala Ile Gly Cys Ile Met Gly Phe Phe Val Thr Val Val Gly Leu 
        115                 120                 125             

Asn His Phe Ile Thr Ser Leu Ala Ala Met Val Ile Val Arg Gly Leu 
    130                 135                 140                 

Cys Leu Val Ile Thr Lys Gly Thr Pro Leu Ser Leu Phe Thr Leu Pro 
145                 150                 155                 160 

Pro Ala Phe Lys Ala Val Gly Gln Gly Thr Phe Phe Gly Val Pro Tyr 
                165                 170                 175     

Val Ile Leu Ile Phe Ile Ala Val Val Gly Ala Phe Asp Phe Leu Leu 
            180                 185                 190         

Arg Arg Ala Thr Ala Phe Arg Lys Val Phe Tyr Thr Gly Ser Asn Glu 
        195                 200                 205             

Lys Ala Ala Leu Tyr Ser Gly Ile Lys Thr Lys Asp Val Lys Phe Trp 
    210                 215                 220                 

Val Thr Val Leu Cys Ala Thr Leu Ser Gly Val Ala Gly Thr Ile Tyr 
225                 230                 235                 240 

Met Ser Arg Phe Gly Ala Ala Thr Pro Thr Phe Gly Val Gly Met Glu 
                245                 250                 255     

Leu Asn Ile Ile Ala Ala Ala Val Ile Gly Gly Ala Ser Leu Asn Gly 
            260                 265                 270         

Gly Ser Gly Thr Ile Leu Gly Ala Ile Leu Gly Ile Ala Leu Leu Ser 
        275                 280                 285             

Val Val Thr Ser Ser Leu Ile Leu Leu Asp Val Ser Val Tyr Trp Gln 
    290                 295                 300                 

Asp Met Ile Lys Gly Cys Ile Leu Leu Ala Ala Val Ser Ile Asp His 
305                 310                 315                 320 

Leu Leu Asn Lys Arg Lys Ala 
                325         

<210>   704
<211>   317
<212>   PRT
<213>   Rhizobium etli CFN 42

<400>   704
Arg Thr Ser Ser Phe Lys Arg Ile Ala Thr Met Arg Glu Ala Gly Leu 
                5                   10                  15      

Ile Ala Ile Ile Leu Ala Leu Gly Ile Val Met Ser Phe Ala Ser Pro 
            20                  25                  30          

His Phe Leu Thr Leu Gly Asn Phe Arg Ala Met Leu Met Ser Phe Ser 
        35                  40                  45              

Val Glu Gly Ile Val Val Val Gly Met Thr Ile Leu Leu Ile Val Gly 
    50                  55                  60                  

Gly Ile Asp Leu Ala Val Gly Ser Val Val Cys Phe Ala Met Val Leu 
65                  70                  75                  80  

Ser Gly Ser Leu Phe Leu Ala Gly Leu Asp Pro Trp Thr Ala Ser Leu 
                85                  90                  95      

Ala Gly Ile Leu Ala Ser Ser Ala Ile Gly Ala Ile Met Gly Phe Phe 
            100                 105                 110         

Val Thr Val Val Gly Leu Asn His Phe Ile Thr Ser Leu Ala Gly Met 
        115                 120                 125             

Val Ile Val Arg Gly Leu Cys Leu Ile Ile Thr Lys Gly Thr Pro Leu 
    130                 135                 140                 

Ser Leu Phe Thr Leu Pro Ala Gly Phe Lys Ala Val Gly Gln Gly Thr 
145                 150                 155                 160 

Phe Tyr Gly Ile Pro Tyr Val Ile Leu Ile Phe Val Ala Val Val Met 
                165                 170                 175     

Leu Phe Asp Phe Leu Leu Arg Arg Ala Thr Ala Phe Arg Lys Val Phe 
            180                 185                 190         

Tyr Thr Gly Ser Asn Glu Lys Ala Ala Leu Tyr Ser Gly Ile Lys Thr 
        195                 200                 205             

Asn Gln Val Lys Phe Trp Val Thr Val Leu Cys Ser Thr Leu Ala Gly 
    210                 215                 220                 

Val Ala Gly Val Ile Tyr Met Ser Arg Phe Gly Ala Ala Thr Pro Thr 
225                 230                 235                 240 

Phe Gly Val Gly Met Glu Leu Asn Ile Ile Ala Ala Ala Val Ile Gly 
                245                 250                 255     

Gly Ala Ser Leu Asn Gly Gly Ser Gly Thr Ile Leu Gly Ala Ile Leu 
            260                 265                 270         

Gly Ile Ala Leu Leu Ser Leu Val Thr Ser Ser Leu Ile Leu Leu Asn 
        275                 280                 285             

Val Ser Val Tyr Trp Gln Asp Met Ile Lys Gly Cys Ile Leu Leu Ala 
    290                 295                 300                 

Ala Val Ser Ile Asp His Phe Leu His Lys Arg Lys Ala 
305                 310                 315         

<210>   705
<211>   353
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   705
Met Thr Lys Pro Ser Trp Ser Thr His Leu Ala Cys Thr Arg Lys Leu 
                5                   10                  15      

Leu Trp Gly Glu Asn Met Gln Pro Val Asp Thr Ala Pro Val Asn Ile 
            20                  25                  30          

Asp Lys Glu Arg Glu Thr Trp Leu Arg Arg Val Ala Arg Ile Arg Glu 
        35                  40                  45              

Leu Thr Ile Val Leu Val Ile Val Ala Leu Cys Ile Ile Leu Ser Phe 
    50                  55                  60                  

Met Ser Ser Ser Phe Leu Ser Val Asp Asn Ile Val Thr Thr Ile Leu 
65                  70                  75                  80  

Ser Ile Val Met Thr Ala Ile Val Ser Val Gly Met Thr Val Ala Leu 
                85                  90                  95      

Val Ser Gly Gly Phe Asp Leu Ser Val Gly Ser Val Met Ser Met Ala 
            100                 105                 110         

Gly Val Val Thr Gly Ser Leu Ala Leu Asn Gly Val Asn Ile Trp Leu 
        115                 120                 125             

Ala Ala Ile Phe Gly Leu Leu Ala Ser Leu Cys Ser Gly Leu Ile Thr 
    130                 135                 140                 

Gly Leu Phe Ile Gly Lys Val Lys Ile Asn Pro Phe Ile Met Thr Leu 
145                 150                 155                 160 

Gly Met Gln Gly Val Val Gln Gly Val Ala Tyr Val Val Thr Gln Gly 
                165                 170                 175     

Ala Pro Leu Ser Val Thr Gly Val Pro Lys Ser Phe Leu Tyr Leu Gly 
            180                 185                 190         

Gln Gly Asn Leu Leu Gly Ile Pro Val Leu Ile Trp Ile Leu Ala Val 
        195                 200                 205             

Val Val Val Val Ser Glu Phe Ile Met Arg Arg Ala Val Val Ala Arg 
    210                 215                 220                 

Lys Val Tyr Tyr Ile Gly Ser Asn Glu Ala Ala Ala Tyr Leu Ser Gly 
225                 230                 235                 240 

Ile Arg Val Ser Lys Val Lys Val Trp Ile Tyr Ile Phe Thr Ala Leu 
                245                 250                 255     

Leu Ala Gly Ile Ala Gly Ile Leu Thr Leu Ser Arg Phe Ser Val Ala 
            260                 265                 270         

Ala Pro Thr Ala Gly Gln Gly Met Glu Leu Gln Ala Ile Ala Ala Cys 
        275                 280                 285             

Ile Ile Gly Gly Ala Ser Leu Thr Gly Gly Glu Gly Thr Val Leu Gly 
    290                 295                 300                 

Ala Leu Leu Gly Ser Val Leu Val Gly Ile Val Asn Asp Ala Leu Val 
305                 310                 315                 320 

Leu Leu Asn Val Ser Val Tyr Trp Gln Ser Leu Val Thr Gly Phe Val 
                325                 330                 335     

Leu Ile Ala Ala Val Thr Leu Asp Val Leu Thr His Arg Lys Lys Ala 
            340                 345                 350         

Asn 
    

<210>   706
<211>   353
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   706
Met Thr Lys Pro Ser Trp Ser Thr His Leu Ala Cys Thr Arg Lys Leu 
                5                   10                  15      

Leu Trp Gly Glu Asn Met Gln Pro Val Asp Thr Ala Pro Val Asn Ile 
            20                  25                  30          

Asp Lys Glu Arg Glu Thr Trp Leu Arg Arg Val Ala Arg Ile Arg Glu 
        35                  40                  45              

Leu Thr Ile Val Leu Val Ile Val Ala Leu Cys Ile Ile Leu Ser Phe 
    50                  55                  60                  

Met Ser Ser Ser Phe Leu Ser Val Asp Asn Ile Val Thr Thr Ile Leu 
65                  70                  75                  80  

Ser Ile Val Met Thr Ala Ile Val Ser Val Gly Met Thr Val Ala Leu 
                85                  90                  95      

Val Ser Gly Gly Phe Asp Leu Ser Val Gly Ser Val Met Ser Met Ala 
            100                 105                 110         

Gly Val Val Thr Gly Ser Leu Ala Leu Asn Gly Val Asn Ile Trp Leu 
        115                 120                 125             

Ala Ala Ile Phe Gly Leu Leu Ala Ser Leu Cys Ser Gly Leu Ile Thr 
    130                 135                 140                 

Gly Leu Phe Ile Gly Lys Ile Lys Ile Asn Pro Phe Ile Met Thr Leu 
145                 150                 155                 160 

Gly Met Gln Gly Val Val Gln Gly Val Ala Tyr Val Val Thr Gln Gly 
                165                 170                 175     

Ala Pro Leu Ser Val Thr Gly Val Pro Lys Ser Phe Leu Tyr Leu Gly 
            180                 185                 190         

Gln Gly Asn Leu Leu Gly Ile Pro Val Leu Ile Trp Ile Leu Ala Val 
        195                 200                 205             

Val Val Val Val Ser Asp Phe Ile Met Arg Arg Ala Val Val Ala Arg 
    210                 215                 220                 

Lys Val Tyr Tyr Ile Gly Ser Asn Glu Ala Ala Ala Tyr Leu Ser Gly 
225                 230                 235                 240 

Ile Arg Val Ser Lys Val Lys Val Trp Ile Tyr Ile Phe Thr Ala Leu 
                245                 250                 255     

Leu Ala Gly Ile Ala Gly Ile Leu Thr Leu Ser Arg Phe Ser Val Ala 
            260                 265                 270         

Ala Pro Thr Ala Gly Gln Gly Met Glu Leu Gln Ala Ile Ala Ala Cys 
        275                 280                 285             

Ile Ile Gly Gly Ala Ser Leu Thr Gly Gly Glu Gly Thr Val Leu Gly 
    290                 295                 300                 

Ala Leu Leu Gly Ser Val Leu Val Gly Ile Val Asn Asp Ala Leu Val 
305                 310                 315                 320 

Leu Leu Asn Val Ser Val Tyr Trp Gln Ser Leu Val Thr Gly Phe Val 
                325                 330                 335     

Leu Ile Ala Ala Val Thr Leu Asp Val Leu Thr His Arg Lys Lys Ala 
            340                 345                 350         

Asn 
    

<210>   707
<211>   353
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   707
Met Thr Lys Pro Ser Trp Ser Thr His Leu Ala Cys Thr Arg Lys Leu 
                5                   10                  15      

Leu Trp Gly Glu Asn Met Gln Pro Val Asp Thr Ala Pro Val Asn Ile 
            20                  25                  30          

Asp Lys Glu Arg Glu Thr Trp Leu Arg Arg Val Ala Arg Ile Arg Glu 
        35                  40                  45              

Leu Thr Ile Val Leu Val Ile Val Ala Leu Cys Ile Ile Leu Ser Phe 
    50                  55                  60                  

Met Ser Ser Ser Phe Leu Ser Val Asp Asn Ile Val Thr Thr Ile Leu 
65                  70                  75                  80  

Ser Ile Val Met Thr Ala Ile Val Ser Val Gly Met Thr Val Ala Leu 
                85                  90                  95      

Val Ser Gly Gly Phe Asp Leu Ser Val Gly Ser Val Met Ser Met Ala 
            100                 105                 110         

Gly Val Val Thr Gly Ser Leu Ala Leu Asn Gly Val Asn Ile Trp Leu 
        115                 120                 125             

Ala Ala Ile Phe Gly Leu Leu Ala Ser Leu Cys Ser Gly Leu Ile Thr 
    130                 135                 140                 

Gly Leu Phe Ile Gly Lys Val Lys Ile Asn Pro Phe Ile Met Thr Leu 
145                 150                 155                 160 

Gly Met Gln Gly Val Val Gln Gly Val Ala Tyr Val Val Thr Gln Gly 
                165                 170                 175     

Ala Pro Leu Ser Val Thr Gly Val Pro Lys Ser Phe Leu Tyr Leu Gly 
            180                 185                 190         

Gln Gly Asn Leu Leu Gly Ile Pro Val Leu Ile Trp Ile Leu Ala Val 
        195                 200                 205             

Val Val Val Val Ser Asp Phe Ile Met Arg Arg Ala Val Val Ala Arg 
    210                 215                 220                 

Lys Val Tyr Tyr Ile Gly Ser Asn Glu Ala Ala Ala Tyr Leu Ser Gly 
225                 230                 235                 240 

Ile Arg Val Ser Lys Val Lys Val Trp Ile Tyr Ile Phe Thr Ala Leu 
                245                 250                 255     

Leu Ala Gly Ile Ala Gly Ile Ile Thr Leu Ser Arg Phe Ser Val Ala 
            260                 265                 270         

Ala Pro Thr Ala Gly Gln Gly Met Glu Leu Gln Ala Ile Ala Ala Cys 
        275                 280                 285             

Ile Ile Gly Gly Ala Ser Leu Thr Gly Gly Glu Gly Thr Val Leu Gly 
    290                 295                 300                 

Ala Leu Leu Gly Ser Val Leu Val Gly Ile Val Asn Asp Ala Leu Val 
305                 310                 315                 320 

Leu Leu Asn Val Ser Val Tyr Trp Gln Ser Leu Val Thr Gly Phe Val 
                325                 330                 335     

Leu Ile Ala Ala Val Thr Leu Asp Val Leu Thr His Arg Lys Lys Ala 
            340                 345                 350         

Asn 
    

<210>   708
<211>   353
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   708
Met Thr Lys Pro Ser Trp Ser Thr His Leu Ala Cys Thr Arg Lys Leu 
                5                   10                  15      

Leu Trp Gly Glu Asn Met Gln Pro Val Asp Thr Ala Pro Val Asn Ile 
            20                  25                  30          

Asp Lys Glu Arg Glu Thr Trp Leu Arg Arg Val Ala Arg Ile Arg Glu 
        35                  40                  45              

Leu Thr Ile Val Leu Val Ile Val Ala Leu Cys Ile Ile Leu Ser Phe 
    50                  55                  60                  

Met Ser Ser Ser Phe Leu Ser Val Asp Asn Ile Val Thr Thr Ile Leu 
65                  70                  75                  80  

Ser Ile Val Met Thr Ala Ile Val Ser Val Gly Met Thr Val Ala Leu 
                85                  90                  95      

Val Ser Gly Gly Phe Asp Leu Ser Val Gly Ser Val Met Ser Met Ala 
            100                 105                 110         

Gly Val Val Thr Gly Ser Leu Ala Leu Asn Gly Val Asn Ile Trp Leu 
        115                 120                 125             

Ala Ala Ile Phe Gly Leu Leu Ala Ser Leu Cys Ser Gly Leu Ile Thr 
    130                 135                 140                 

Gly Leu Phe Ile Gly Lys Val Lys Ile Asn Pro Phe Ile Met Thr Leu 
145                 150                 155                 160 

Gly Met Gln Gly Val Val Gln Gly Val Ala Tyr Val Val Thr Gln Gly 
                165                 170                 175     

Ala Pro Leu Ser Val Thr Gly Val Pro Lys Ser Phe Leu Tyr Leu Gly 
            180                 185                 190         

Gln Gly Asn Leu Leu Gly Ile Pro Val Leu Ile Trp Ile Leu Ala Val 
        195                 200                 205             

Val Val Val Val Ser Asp Phe Ile Met Arg Arg Ala Val Val Ala Arg 
    210                 215                 220                 

Lys Val Tyr Tyr Leu Gly Ser Asn Glu Ala Ala Ala Tyr Leu Ser Gly 
225                 230                 235                 240 

Ile Arg Val Ser Lys Val Lys Val Trp Ile Tyr Ile Phe Thr Ala Leu 
                245                 250                 255     

Leu Ala Gly Ile Ala Gly Ile Leu Thr Leu Ser Arg Phe Ser Val Ala 
            260                 265                 270         

Ala Pro Thr Ala Gly Gln Gly Met Glu Leu Gln Ala Ile Ala Ala Cys 
        275                 280                 285             

Ile Ile Gly Gly Ala Ser Leu Thr Gly Gly Glu Gly Thr Val Leu Gly 
    290                 295                 300                 

Ala Leu Leu Gly Ser Val Leu Val Gly Ile Val Asn Asp Ala Leu Val 
305                 310                 315                 320 

Leu Leu Asn Val Ser Val Tyr Trp Gln Ser Leu Val Thr Gly Phe Val 
                325                 330                 335     

Leu Ile Ala Ala Val Thr Leu Asp Val Leu Thr His Arg Lys Lys Ala 
            340                 345                 350         

Asn 
    

<210>   709
<211>   353
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 698

<400>   709
Met Thr Lys Pro Ser Trp Ser Thr His Leu Ala Cys Thr Arg Lys Leu 
                5                   10                  15      

Leu Trp Gly Glu Asn Met Gln Pro Val Asp Thr Ala Pro Val Asn Ile 
            20                  25                  30          

Asp Lys Glu Arg Glu Thr Trp Leu Arg Arg Val Ala Arg Ile Arg Glu 
        35                  40                  45              

Leu Thr Ile Val Leu Val Ile Val Ala Leu Cys Ile Ile Leu Ser Phe 
    50                  55                  60                  

Met Ser Ser Ser Phe Leu Ser Val Asp Asn Ile Val Thr Thr Ile Leu 
65                  70                  75                  80  

Ser Ile Val Met Thr Ala Ile Val Ser Val Gly Met Thr Val Ala Leu 
                85                  90                  95      

Val Ser Gly Gly Phe Asp Leu Ser Val Gly Ser Val Met Ser Met Ala 
            100                 105                 110         

Gly Val Val Thr Gly Ser Leu Ala Leu Asn Gly Val Asn Ile Trp Leu 
        115                 120                 125             

Ala Ala Ile Phe Gly Leu Leu Ala Ser Leu Cys Ser Gly Leu Ile Thr 
    130                 135                 140                 

Gly Leu Phe Ile Gly Lys Val Lys Ile Asn Pro Phe Ile Met Thr Leu 
145                 150                 155                 160 

Gly Met Asn Gly Val Val Gln Gly Val Ala Tyr Val Val Thr Gln Gly 
                165                 170                 175     

Ala Pro Leu Ser Val Thr Gly Val Pro Lys Ser Phe Leu Tyr Leu Gly 
            180                 185                 190         

Gln Gly Asn Leu Leu Gly Ile Pro Val Leu Ile Trp Ile Leu Ala Val 
        195                 200                 205             

Val Val Val Val Ser Asp Phe Ile Met Arg Arg Ala Val Val Ala Arg 
    210                 215                 220                 

Lys Val Tyr Tyr Ile Gly Ser Asn Glu Ala Ala Ala Tyr Leu Ser Gly 
225                 230                 235                 240 

Ile Arg Val Ser Lys Val Lys Val Trp Ile Tyr Ile Phe Thr Ala Leu 
                245                 250                 255     

Leu Ala Gly Ile Ala Gly Ile Leu Thr Leu Ser Arg Phe Ser Val Ala 
            260                 265                 270         

Ala Pro Thr Ala Gly Gln Gly Met Glu Leu Gln Ala Ile Ala Ala Cys 
        275                 280                 285             

Ile Ile Gly Gly Ala Ser Leu Thr Gly Gly Glu Gly Thr Val Leu Gly 
    290                 295                 300                 

Ala Leu Leu Gly Ser Val Leu Val Gly Ile Val Asn Asp Ala Leu Val 
305                 310                 315                 320 

Leu Leu Asn Val Ser Val Tyr Trp Gln Ser Leu Val Thr Gly Phe Val 
                325                 330                 335     

Leu Ile Ala Ala Val Thr Leu Asp Val Leu Thr His Arg Lys Lys Ala 
            340                 345                 350         

Asn 
    

<210>   710
<211>   1062
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   710
atgacgaaac catcatggag tacgcatctg gcttgcacaa ggaaactgct gtggggtgag       60

aacatgcaac cagtggacac cgctcccgtc aatatcgaca aagaacgcga gacgtggctt      120

cggagagtcg cgcgtattcg agaacttact attgtcctcg tgatcgtggc tctctgcatc      180

attctgtcct tcatgtcgtc gtcatttctg agtgttgata acatcgtcac gacgattttg      240

agcatcgtca tgacagccat tgtatcggtg ggcatgacag tggcactcgt gtccggaggg      300

ttcgacctct cggtcggctc cgtgatgtcc atggcaggtg tggtcacggg aagcttggca      360

ttaaatggtg tgaacatttg gctggcggcg atctttggtc tgttggccag cctgtgctcc      420

gggctgatta caggtctatt tatcggcaag gtcaagatca atccgttcat catgaccctc      480

ggtatgcagg gcgtggttca aggtgtggct tacgtcgtga cccagggtgc gccgttgtcc      540

gtcacgggtg taccgaagtc gtttctctac cttggtcagg gcaatttgct gggcattccc      600

gttctcatct ggattctggc ggtcgtggtt gttgtctccg aattcatcat gaggcgtgca      660

gtcgttgctc gtaaggtgta ctacatcggc agcaacgaag cggctgcgta cttgtctggt      720

attcgagtct ccaaggtaaa ggtttggatc tacattttca ccgctctatt ggcgggcatc      780

gcgggaattc tgacactctc gcggttcagc gtagctgcac cgaccgctgg gcagggtatg      840

gaacttcagg ccattgctgc gtgtatcatc ggcggtgcca gcttgacggg aggtgagggt      900

accgtcctcg gagcactgct cggtagcgtg ctcgtgggca tcgtaaatga tgcgttggtg      960

ctgttgaacg tatccgttta ttggcagagc cttgttacag gcttcgttct gattgctgcg     1020

gtgacgttag acgtcctgac ccacaggaaa aaggcaaatt ga                        1062


<210>   711
<211>   1062
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   711
atgacgaaac catcatggag tacgcatctg gcttgcacaa ggaaactgct gtggggtgag       60

aacatgcaac cagtggacac cgctcccgtc aatatcgaca aagaacgcga gacgtggctt      120

cggagagtcg cgcgtattcg agaacttact attgtcctcg tgatcgtggc tctctgcatc      180

attctgtcct tcatgtcgtc gtcatttctg agtgttgata acatcgtcac gacgattttg      240

agcatcgtca tgacagccat tgtatcggtg ggcatgacag tggcactcgt gtccggaggg      300

ttcgacctct cggtcggctc cgtgatgtcc atggcaggtg tggtcacggg aagcttggca      360

ttaaatggtg tgaacatttg gctggcggcg atctttggtc tgttggccag cctgtgctcc      420

gggctgatta caggtctatt tatcggcaag attaagatca atccgttcat catgaccctc      480

ggtatgcagg gcgtggttca aggtgtggct tacgtcgtga cccagggtgc gccgttgtcc      540

gtcacgggtg taccgaagtc gtttctctac cttggtcagg gcaatttgct gggcattccc      600

gttctcatct ggattctggc ggtcgtggtt gttgtctccg acttcatcat gaggcgtgca      660

gtcgttgctc gtaaggtgta ctacatcggc agcaacgaag cggctgcgta cttgtctggt      720

attcgagtct ccaaggtaaa ggtttggatc tacattttca ccgctctatt ggcgggcatc      780

gcgggaattc tgacactctc gcggttcagc gtagctgcac cgaccgctgg gcagggtatg      840

gaacttcagg ccattgctgc gtgtatcatc ggcggtgcca gcttgacggg aggtgagggt      900

accgtcctcg gagcactgct cggtagcgtg ctcgtgggca tcgtaaatga tgcgttggtg      960

ctgttgaacg tatccgttta ttggcagagc cttgttacag gcttcgttct gattgctgcg     1020

gtgacgttag acgtcctgac ccacaggaaa aaggcaaatt ga                        1062


<210>   712
<211>   1062
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   712
atgacgaaac catcatggag tacgcatctg gcttgcacaa ggaaactgct gtggggtgag       60

aacatgcaac cagtggacac cgctcccgtc aatatcgaca aagaacgcga gacgtggctt      120

cggagagtcg cgcgtattcg agaacttact attgtcctcg tgatcgtggc tctctgcatc      180

attctgtcct tcatgtcgtc gtcatttctg agtgttgata acatcgtcac gacgattttg      240

agcatcgtca tgacagccat tgtatcggtg ggcatgacag tggcactcgt gtccggaggg      300

ttcgacctct cggtcggctc cgtgatgtcc atggcaggtg tggtcacggg aagcttggca      360

ttaaatggtg tgaacatttg gctggcggcg atctttggtc tgttggccag cctgtgctcc      420

gggctgatta caggtctatt tatcggcaag gtcaagatca atccgttcat catgaccctc      480

ggtatgcagg gcgtggttca aggtgtggct tacgtcgtga cccagggtgc gccgttgtcc      540

gtcacgggtg taccgaagtc gtttctctac cttggtcagg gcaatttgct gggcattccc      600

gttctcatct ggattctggc ggtcgtggtt gttgtctccg acttcatcat gaggcgtgca      660

gtcgttgctc gtaaggtgta ctacatcggc agcaacgaag cggctgcgta cttgtctggt      720

attcgagtct ccaaggtaaa ggtttggatc tacattttca ccgctctatt ggcgggcatc      780

gcgggaatta ttacactctc gcggttcagc gtagctgcac cgaccgctgg gcagggtatg      840

gaacttcagg ccattgctgc gtgtatcatc ggcggtgcca gcttgacggg aggtgagggt      900

accgtcctcg gagcactgct cggtagcgtg ctcgtgggca tcgtaaatga tgcgttggtg      960

ctgttgaacg tatccgttta ttggcagagc cttgttacag gcttcgttct gattgctgcg     1020

gtgacgttag acgtcctgac ccacaggaaa aaggcaaatt ga                        1062


<210>   713
<211>   1062
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   713
atgacgaaac catcatggag tacgcatctg gcttgcacaa ggaaactgct gtggggtgag       60

aacatgcaac cagtggacac cgctcccgtc aatatcgaca aagaacgcga gacgtggctt      120

cggagagtcg cgcgtattcg agaacttact attgtcctcg tgatcgtggc tctctgcatc      180

attctgtcct tcatgtcgtc gtcatttctg agtgttgata acatcgtcac gacgattttg      240

agcatcgtca tgacagccat tgtatcggtg ggcatgacag tggcactcgt gtccggaggg      300

ttcgacctct cggtcggctc cgtgatgtcc atggcaggtg tggtcacggg aagcttggca      360

ttaaatggtg tgaacatttg gctggcggcg atctttggtc tgttggccag cctgtgctcc      420

gggctgatta caggtctatt tatcggcaag gtcaagatca atccgttcat catgaccctc      480

ggtatgcagg gcgtggttca aggtgtggct tacgtcgtga cccagggtgc gccgttgtcc      540

gtcacgggtg taccgaagtc gtttctctac cttggtcagg gcaatttgct gggcattccc      600

gttctcatct ggattctggc ggtcgtggtt gttgtctccg acttcatcat gaggcgtgca      660

gtcgttgctc gtaaggtgta ctacttaggc agcaacgaag cggctgcgta cttgtctggt      720

attcgagtct ccaaggtaaa ggtttggatc tacattttca ccgctctatt ggcgggcatc      780

gcgggaattc tgacactctc gcggttcagc gtagctgcac cgaccgctgg gcagggtatg      840

gaacttcagg ccattgctgc gtgtatcatc ggcggtgcca gcttgacggg aggtgagggt      900

accgtcctcg gagcactgct cggtagcgtg ctcgtgggca tcgtaaatga tgcgttggtg      960

ctgttgaacg tatccgttta ttggcagagc cttgttacag gcttcgttct gattgctgcg     1020

gtgacgttag acgtcctgac ccacaggaaa aaggcaaatt ga                        1062


<210>   714
<211>   1062
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 699

<400>   714
atgacgaaac catcatggag tacgcatctg gcttgcacaa ggaaactgct gtggggtgag       60

aacatgcaac cagtggacac cgctcccgtc aatatcgaca aagaacgcga gacgtggctt      120

cggagagtcg cgcgtattcg agaacttact attgtcctcg tgatcgtggc tctctgcatc      180

attctgtcct tcatgtcgtc gtcatttctg agtgttgata acatcgtcac gacgattttg      240

agcatcgtca tgacagccat tgtatcggtg ggcatgacag tggcactcgt gtccggaggg      300

ttcgacctct cggtcggctc cgtgatgtcc atggcaggtg tggtcacggg aagcttggca      360

ttaaatggtg tgaacatttg gctggcggcg atctttggtc tgttggccag cctgtgctcc      420

gggctgatta caggtctatt tatcggcaag gtcaagatca atccgttcat catgaccctc      480

ggtatgaatg gcgtggttca aggtgtggct tacgtcgtga cccagggtgc gccgttgtcc      540

gtcacgggtg taccgaagtc gtttctctac cttggtcagg gcaatttgct gggcattccc      600

gttctcatct ggattctggc ggtcgtggtt gttgtctccg acttcatcat gaggcgtgca      660

gtcgttgctc gtaaggtgta ctacatcggc agcaacgaag cggctgcgta cttgtctggt      720

attcgagtct ccaaggtaaa ggtttggatc tacattttca ccgctctatt ggcgggcatc      780

gcgggaattc tgacactctc gcggttcagc gtagctgcac cgaccgctgg gcagggtatg      840

gaacttcagg ccattgctgc gtgtatcatc ggcggtgcca gcttgacggg aggtgagggt      900

accgtcctcg gagcactgct cggtagcgtg ctcgtgggca tcgtaaatga tgcgttggtg      960

ctgttgaacg tatccgttta ttggcagagc cttgttacag gcttcgttct gattgctgcg     1020

gtgacgttag acgtcctgac ccacaggaaa aaggcaaatt ga                        1062


<210>   715
<211>   370
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   715
Met Ala Lys Lys Thr Trp Lys Lys Ser Ala Thr Trp Met Ala Ala Ala 
                5                   10                  15      

Ala Val Val Thr Gly Ile Val Ala Gly Cys Gly Thr Ser Ser Ala Asn 
            20                  25                  30          

Gly Gln Gly Ser Thr Ser Thr Gly Ala Ala Ser Ala Val Asn Pro His 
        35                  40                  45              

Pro Ser Val Lys Ile Ala Phe Leu Met Pro Glu Thr Asn Thr Ser Pro 
    50                  55                  60                  

Arg Trp Glu Tyr Asp Asp Arg Pro Asp Phe Ile Ala Ala Met Lys Lys 
65                  70                  75                  80  

Leu Asp Pro Asn Ala Gln Ile Ile Tyr Ala Asn Ala Gln Gly Ser Glu 
                85                  90                  95      

Ala Thr Gln Leu Gln Gln Val Glu Ser Ala Ile Thr Glu Gly Ala Lys 
            100                 105                 110         

Leu Leu Val Val Ala Pro Val Asn Gly Phe Ala Ala Thr Thr Ile Val 
        115                 120                 125             

Thr Glu Ala Ala Lys Ala His Val Pro Val Ile Ser Tyr Asp Arg Leu 
    130                 135                 140                 

Ile Gln Asn Ala Lys Val Asp Tyr Tyr Val Ser Phe Asn Asn Val Glu 
145                 150                 155                 160 

Val Gly Lys Leu Gln Gly Glu Tyr Ile Ala Gln His Thr Lys Lys Gly 
                165                 170                 175     

Gly Thr Val Val Met Leu Asp Gly Ala Pro Thr Asp Pro Asn Ala Lys 
            180                 185                 190         

Gln Phe Ala Gln Gly Ala His Asp Val Leu Asp Pro Leu Phe Lys Ser 
        195                 200                 205             

Gly Lys Leu Lys Leu Gly Tyr Glu Gln Phe Thr Pro Asn Trp Asp Ser 
    210                 215                 220                 

Gln Gln Ala Leu Thr Glu Met Gln Gln Ala Leu Thr Arg Leu His Asn 
225                 230                 235                 240 

His Val Asp Ala Val Leu Ala Ala Asn Asp Asn Leu Ala Gly Ala Ala 
                245                 250                 255     

Ile Gln Ala Leu Glu Gln Gln His Ile Lys Gly Ile Pro Val Thr Gly 
            260                 265                 270         

Gln Asp Ala Thr Asp Ala Gly Leu His Arg Ile Tyr Tyr Glu Gly Thr 
        275                 280                 285             

Gln Ser Met Thr Val Tyr Lys Pro Ile Lys Glu Glu Ala Asn Ala Ala 
    290                 295                 300                 

Ala Gln Leu Ala Tyr Asp Leu Ile Thr Gly Lys Lys Pro Pro Ala Ser 
305                 310                 315                 320 

Leu Val Asn Gly Thr Val Asn Asn Gly Ala Thr Asn Val Pro Ser Val 
                325                 330                 335     

Leu Leu Gln Pro Ile Val Val Thr Lys Ser Asn Val Ala Ser Thr Val 
            340                 345                 350         

Ile Lys Asp Gly Phe Thr Thr Trp Ala Arg Ile Lys Asn Pro Ala Glu 
        355                 360                 365             

Gln Gln 
    370 

<210>   716
<211>   1113
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   716
gtggccaaga agacatggaa gaagagcgca acgtggatgg cggcggcggc cgtcgtgacg       60

gggattgtcg ctgggtgcgg cacctcttcg gcgaatgggc agggctcgac gtcgacgggc      120

gcggcgtctg cagtgaatcc gcacccgagc gtcaaaatcg cgtttctgat gccggagacg      180

aacacgtcgc cgcgttggga gtacgatgat cgcccggact tcatcgcggc gatgaagaag      240

ctggatccga acgcgcagat catctatgcc aacgcgcagg ggtctgaggc gacgcagctt      300

cagcaggtgg aaagcgccat cacggagggt gcgaagctcc tcgtcgtggc accggtgaac      360

gggtttgcgg ccacgaccat cgtcaccgag gccgcgaaag cgcacgttcc cgtgatctcg      420

tacgatcgcc tcattcagaa cgccaaggtc gactattacg tctcgttcaa caacgtcgag      480

gtcggcaagc ttcagggcga gtacatcgcg cagcacacca agaagggcgg caccgtggtc      540

atgttggacg gcgcgcccac ggatccgaac gcgaagcagt tcgcgcaggg cgcccatgac      600

gtcctggatc cgctctttaa atcgggcaag ctgaagctcg gttatgagca gttcacgccg      660

aactgggatt cgcagcaggc gctgaccgag atgcagcagg cgctcacgcg gctgcacaat      720

cacgtggacg ccgtgctggc tgcgaacgac aacctggcgg gcgcggccat ccaggcgctt      780

gagcagcagc acatcaaggg catccccgtg acaggccagg atgcgaccga cgccggcctg      840

caccggattt attacgaagg cacccagtcg atgacggtgt acaagcccat caaggaagag      900

gccaacgcag cggctcagct ggcgtatgac ctcatcacgg gcaagaagcc gccggcatcg      960

ctcgtgaatg gcacggtgaa caacggtgcc acgaacgtgc cgtccgtgct cctgcagccc     1020

atcgttgtga cgaagtcgaa cgtcgcaagc acggtcatca aggacggctt cacgacctgg     1080

gcgcgcatca agaacccggc agagcagcag taa                                  1113


<210>   717
<211>   341
<212>   PRT
<213>   Acidiphilium cryptum JF-5

<400>   717
Gly Leu Thr Ala Ala His Ala Gln Ser Val Thr Gln Pro Ser Val His 
                5                   10                  15      

Gln Ile Ser Ser Lys Lys Thr Thr Ile Ala Phe Leu Leu Pro Glu Asn 
            20                  25                  30          

Ser Ser Pro Arg Tyr Glu Gln Val Asp Arg Pro Trp Phe Ile Lys Met 
        35                  40                  45              

Ala His Ala Ala Asp Pro Asn Ala Lys Leu Ile Val Ser Asn Ala Asn 
    50                  55                  60                  

Ser Ser Pro Asp Thr Gln Leu Asn Gln Ala Glu Ser Ala Ile Ser Asn 
65                  70                  75                  80  

Gly Ala Asp Val Leu Val Val Asp Pro Val Asp Gly Lys Ala Gly Ala 
                85                  90                  95      

Ala Ile Val Asn Tyr Ala Ala Arg Asn His Val Lys Val Ile Ser Tyr 
            100                 105                 110         

Asp Arg Leu Ile Gln Asp Ser Lys Pro Asp Tyr Tyr Val Ser Phe Asp 
        115                 120                 125             

Asn Thr Lys Val Gly Glu Leu Gln Gly Glu Tyr Ile Ala Lys His Thr 
    130                 135                 140                 

Lys Pro Gly Gly Ser Val Met Met Ile Asn Gly Ala Pro Thr Asp Pro 
145                 150                 155                 160 

Asn Ala Phe Asp Phe Arg Lys Gly Ala Met Asn Val Leu Gly Pro Leu 
                165                 170                 175     

Phe Lys Ser Gly Lys Leu His Leu Ala Tyr Ser Val Met Thr Pro Asp 
            180                 185                 190         

Trp Ser Pro Gln Asn Ala Phe Glu Glu Ser Gln Gln Ala Leu Thr Arg 
        195                 200                 205             

Leu His Asn Lys Val Asn Ala Val Leu Ala Ala Asn Asp Gly Thr Ala 
    210                 215                 220                 

Ser Gly Val Ile Arg Ala Leu Gln Ala Val Gly Leu Ala Gly Lys Val 
225                 230                 235                 240 

Pro Val Thr Gly Gln Asp Ala Thr Asn Gly Gly Leu Thr Phe Ile Leu 
                245                 250                 255     

Glu Gly Leu Gln Ser Met Thr Val Phe Lys Tyr Val Pro Glu Glu Ala 
            260                 265                 270         

Ala Ala Ala Ala Glu Leu Ala Val Ala Val Ala Thr Asp Thr Lys Pro 
        275                 280                 285             

Pro Ala Gly Leu Leu Asn Gly Lys Thr Asn Asn Lys Met Ile Asp Val 
    290                 295                 300                 

Pro Ser Val Leu Leu Lys Pro Leu Val Val Thr Lys Ala Asn Ile Ala 
305                 310                 315                 320 

Gly Ser Val Ile Lys Ser Gly Tyr Thr Thr Trp Lys Ala Ile Cys Val 
                325                 330                 335     

Gly Pro Ala Ala Gln 
            340     

<210>   718
<211>   324
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   718
Thr Ala Pro Thr Thr Gly Thr Gly Gly Thr Thr Ser Ser Gly Gly Lys 
                5                   10                  15      

Val Val Ala Leu Phe Leu Pro Asp Ala Lys Thr Ala Arg Tyr Glu Thr 
            20                  25                  30          

Ala Asp Arg Pro Tyr Phe Glu Ala Lys Met Lys Glu Leu Cys Pro Asp 
        35                  40                  45              

Cys Gln Val Ile Tyr Asn Asn Ala Asn Gln Asp Ala Ser Leu Gln Leu 
    50                  55                  60                  

Gln Gln Ala Glu Ala Ala Leu Thr Asn Gly Ala Lys Val Leu Val Leu 
65                  70                  75                  80  

Asp Pro Val Asp Ser Ala Ala Ala Ala Ser Ile Ala Asp Lys Ala Lys 
                85                  90                  95      

Ala Gln Asn Val Pro Val Ile Ala Tyr Asp Arg Leu Ile Leu Asn Ser 
            100                 105                 110         

Asp Gly Val Ser Tyr Tyr Ile Ser Phe Asp Asn Glu Ser Val Gly Lys 
        115                 120                 125             

Leu Gln Ala Glu Ser Leu Val Ala Gln Leu Asp Lys Gln Gly Ile Ala 
    130                 135                 140                 

Asn Pro Thr Ile Val Met Ile Asn Gly Ser Pro Thr Asp Asn Asn Ala 
145                 150                 155                 160 

Lys Leu Phe Lys Ala Gly Ala His Ser Val Phe Asp Pro Leu Val Ser 
                165                 170                 175     

Ala Gly Lys Leu Thr Ile Ala Asn Glu Tyr Asp Thr Pro Asp Trp Ser 
            180                 185                 190         

Pro Asp Lys Ala Gln Asp Gln Met Gln Gln Ala Leu Thr Ser Met Gly 
        195                 200                 205             

Asn Lys Val Asp Gly Val Tyr Ala Ala Asn Asp Gly Thr Gly Gly Gly 
    210                 215                 220                 

Ala Ile Ala Ala Met Lys Ala Gly Gly Leu Ser Pro Leu Pro Pro Val 
225                 230                 235                 240 

Thr Gly Gln Asp Ala Glu Leu Ala Ala Ile Gln Arg Ile Leu Ala Gly 
                245                 250                 255     

Asp Gln Tyr Met Thr Val Tyr Lys Ala Ile Lys Pro Gln Ala Glu Ala 
            260                 265                 270         

Ala Ala Glu Leu Ala Phe Ala Leu Leu Glu Gly Lys Thr Ser Asp Lys 
        275                 280                 285             

Ala Thr Ser Lys Val Asn Asn Gly Lys Ile Asp Val Pro Ser Ile Leu 
    290                 295                 300                 

Leu Thr Pro Ile Ala Val Thr Lys Glu Asn Val Lys Asp Thr Ile Val 
305                 310                 315                 320 

Lys Asp Gln Phe 
                

<210>   719
<211>   305
<212>   PRT
<213>   Stigmatella aurantiaca DW4/3-1

<400>   719
Lys Ile Ala Leu Leu Leu Pro Glu Ser Lys Thr Ser Arg Tyr Glu Ser 
                5                   10                  15      

His Asp Arg Pro His Phe Glu Arg Lys Val Lys Glu Leu Cys Pro Asp 
            20                  25                  30          

Cys Glu Val Ile Tyr Ser Asn Ala Asp Gln Asp Ala Ser Lys Gln Gln 
        35                  40                  45              

Ser Gln Thr Glu Ala Ala Leu Thr Asn Gly Ala Gln Val Leu Val Leu 
    50                  55                  60                  

Asp Pro Val Asp Ser Ala Ser Ala Ala Ala Met Val Ala Arg Ala Arg 
65                  70                  75                  80  

Gln Ser Lys Val Pro Val Ile Ser Tyr Asp Arg Leu Ile Thr Asn Ser 
                85                  90                  95      

Asp Val Asp Tyr Tyr Ile Ser Phe Asp Asn Glu Lys Val Gly Lys Leu 
            100                 105                 110         

Gln Gly Gln Ala Leu Leu Asp Lys Leu Lys Ala Asp Gly Lys Asp Lys 
        115                 120                 125             

Gly Thr Ile Val Ile Ile Asn Gly Ala Pro Thr Asp Asn Asn Ala Lys 
    130                 135                 140                 

Leu Phe Lys Ala Gly Ala His Ser Ile Leu Asp Gly Ser Gly Leu Val 
145                 150                 155                 160 

Val Gly Ala Glu Tyr Asp Thr Pro Asp Trp Ser Pro Asp Lys Ala Gln 
                165                 170                 175     

Gln Gln Met Glu Gln Ala Val Thr Ser Leu Gly Lys Asp Lys Ile Val 
            180                 185                 190         

Gly Val Tyr Ala Ala Asn Asp Gly Thr Ala Gly Gly Ala Ile Ala Ala 
        195                 200                 205             

Met Lys Ala Ala Gly Val Asn Pro Leu Pro Pro Val Thr Gly Gln Asp 
    210                 215                 220                 

Ala Glu Leu Ala Gly Ile Gln Arg Val Leu Val Gly Glu Gln Tyr Met 
225                 230                 235                 240 

Thr Val Tyr Lys Ala Ile Lys Pro Glu Ala Glu Ala Ala Ala Glu Leu 
                245                 250                 255     

Ala Val Ala Leu Leu Arg Gly Gln Val Pro Glu Gly Lys Val Asn Ala 
            260                 265                 270         

Lys Val Asn Asn Gly Gln Lys Asp Val Pro Ser Ile Leu Leu Pro Pro 
        275                 280                 285             

Val Ser Val Thr Lys Glu Asn Val Lys Ser Thr Ile Val Ala Asp Gly 
    290                 295                 300                 

Phe 
305 

<210>   720
<211>   302
<212>   PRT
<213>   Frankia sp. EAN1pec

<400>   720
Ile Ala Leu Leu Leu Pro Glu Thr Gln Thr Thr Arg Tyr Glu Ser Ala 
                5                   10                  15      

Asp Arg Pro Tyr Phe Glu Ala Arg Met Ala Lys Ile Cys Pro Asp Cys 
            20                  25                  30          

Lys Val Leu Tyr Ser Asn Ala Asp Gln Asp Ser Ala Ala Gln Gln Asn 
        35                  40                  45              

Gln Ala Glu Gln Ala Met Thr Asn Gly Ala Lys Val Leu Val Leu Asp 
    50                  55                  60                  

Pro Val Asp Gly Glu Ala Ala Ala Val Ile Ala Arg Asn Ala Arg Asp 
65                  70                  75                  80  

Arg Gly Val Arg Val Val Ser Tyr Asp Arg Leu Ile Gln Lys Ala Pro 
                85                  90                  95      

Val Asp Ala Tyr Ile Ser Phe Asp Asn Glu Lys Val Gly Gln Leu Gln 
            100                 105                 110         

Gly Gln Ala Leu Leu Asp Ala Ile Gly Asp Arg Ala Gly Ala Gly Lys 
        115                 120                 125             

Val Ile Met Ile Asn Gly Ser Gln Asp Asp Pro Asn Ala Gln Gln Phe 
    130                 135                 140                 

Lys Asp Gly Ala Leu Ser Val Leu Glu Gly Lys Val Thr Ile Gly Phe 
145                 150                 155                 160 

Asp Thr Phe Thr Pro Asp Trp Ser Pro Asp Thr Ala Gly Arg Glu Met 
                165                 170                 175     

Asp Gln Ala Ile Thr Thr Val Gly Arg Glu Asn Ile Val Gly Val Tyr 
            180                 185                 190         

Ala Ala Asn Asp Gly Met Ala Gly Ala Val Val Ala Ala Leu Arg Arg 
        195                 200                 205             

Ala Asn Val Asn Pro Leu Pro Pro Val Thr Gly Gln Asp Ala Glu Leu 
    210                 215                 220                 

Ala Gly Val Gln Arg Val Leu Ala Gly Asp Gln His Met Thr Val Tyr 
225                 230                 235                 240 

Lys Ala Ile Arg Pro Glu Ala Glu Gln Ala Ala Asp Leu Ala Leu Ala 
                245                 250                 255     

Leu Leu Arg Gly Glu Pro Val Asp Thr Ile Ala Thr Gly His Val Asp 
            260                 265                 270         

Asn Gly Asn Gly Gln Val Pro Ala Val Leu Leu Glu Pro Val Ala Val 
        275                 280                 285             

Thr Arg Asp Thr Val Ala Ala Thr Val Val Lys Asp Gly Phe 
    290                 295                 300         

<210>   721
<211>   321
<212>   PRT
<213>   Moorella thermoacetica ATCC 39073

<400>   721
Gly Gln Gly Gly Asn Ser Ser Lys Asn Gly Gly Asn Gln Gly Ala Ser 
                5                   10                  15      

Ala Lys Asn Gly Asp Lys Ile Lys Ile Gly Leu Ser Met Asp Asp Leu 
            20                  25                  30          

Arg Gln Glu Arg Trp Gln His Asp Arg Asp Leu Phe Val Ala Lys Ala 
        35                  40                  45              

Lys Glu Leu Gly Ala Glu Val Leu Val Gln Ser Ala Asn Gly Asp Asp 
    50                  55                  60                  

Ala Thr Gln Leu Ser Gln Ala Glu Asn Leu Ile Ser Gln Gly Ile Asn 
65                  70                  75                  80  

Val Leu Val Val Ile Pro His Asn Gly Asp Ala Met Ala Pro Ile Val 
                85                  90                  95      

Glu Ala Ala His Lys Ala Gly Val Lys Val Leu Ala Tyr Asp Arg Leu 
            100                 105                 110         

Ile Arg Asn Ala Asp Val Asp Leu Tyr Ile Ser Phe Asp Asn Val Arg 
        115                 120                 125             

Val Gly Glu Leu Gln Ala Glu Tyr Leu Thr Lys Lys Val Pro Lys Gly 
    130                 135                 140                 

Lys Tyr Phe Leu Met Gly Gly Ser Pro Thr Asp Asn Asn Ala Lys Leu 
145                 150                 155                 160 

Phe Arg Gln Gly Gln Met Asn Val Leu Lys Pro Leu Ile Asp Lys Gly 
                165                 170                 175     

Asp Ile Lys Val Val Gly Asp Gln Trp Val Lys Asp Trp Leu Pro Glu 
            180                 185                 190         

Glu Ala Met Lys Ile Met Glu Asn Ala Leu Thr Ser Asn Asn Asn Gln 
        195                 200                 205             

Ile Asp Ala Val Val Ala Ser Asn Asp Ser Thr Ala Gly Gly Ala Ile 
    210                 215                 220                 

Gln Ala Leu Ala Ala Gln Asn Leu Ala Gly Lys Val Ala Ile Ser Gly 
225                 230                 235                 240 

Gln Asp Ala Asp Leu Ala Ala Cys Gln Arg Ile Val Glu Gly Thr Gln 
                245                 250                 255     

Ser Met Thr Val Tyr Lys Pro Ile Thr Thr Leu Ala Thr Arg Ala Ala 
            260                 265                 270         

Glu Val Ala Val Ala Leu Ala Lys Gly Glu Asn Ile Gly Ala Asn Asn 
        275                 280                 285             

Lys Val Asn Asn Gly Lys Ile Asp Val Pro Ser Val Leu Leu Thr Pro 
    290                 295                 300                 

Ile Met Val Asp Lys Asp Asn Met Val Gln Thr Val Ile Lys Asp Gly 
305                 310                 315                 320 

Phe 
    

<210>   722
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   722
Met Ala Lys Lys Thr Trp Lys Lys Ser Ala Thr Trp Met Ala Ala Ala 
                5                   10                  15      

Ala Val Val Thr Gly Ile Val Ala Gly Cys Gly Thr Ser Ser Ala Asn 
            20                  25                  30          

Gly Gln Gly Ser Thr Ser Thr Gly Ala Ala Ser Ala Val Asn Pro His 
        35                  40                  45              

Pro Ser Val Lys Ile Ala Phe Leu Met Pro Glu Thr Asn Thr Ser Pro 
    50                  55                  60                  

Arg Trp Glu Tyr Asp Asp Arg Pro Asp Phe Ile Ala Ala Met Lys Lys 
65                  70                  75                  80  

Leu Asp Pro Asn Ala Gln Ile Ile Tyr Ala Asn Ala Gln Gly Ser Glu 
                85                  90                  95      

Ala Thr Gln Leu Gln Gln Val Glu Ser Ala Ile Thr Glu Gly Ala Lys 
            100                 105                 110         

Leu Leu Val Val Ala Pro Val Asn Gly Phe Ala Ala Thr Thr Ile Val 
        115                 120                 125             

Thr Glu Ala Ala Lys Ala His Val Pro Val Ile Ser Tyr Asp Arg Leu 
    130                 135                 140                 

Ile Gln Asn Ala Lys Val Asp Tyr Tyr Val Ser Phe Asn Asn Val Glu 
145                 150                 155                 160 

Val Gly Lys Leu Gln Gly Glu Tyr Ile Ala Gln His Thr Lys Lys Gly 
                165                 170                 175     

Gly Thr Val Val Met Leu Asp Gly Ala Pro Thr Asp Pro Asn Ala Lys 
            180                 185                 190         

Gln Phe Ala Gln Gly Ala His Asp Val Leu Asp Pro Leu Phe Lys Ser 
        195                 200                 205             

Gly Lys Leu Lys Leu Gly Tyr Glu Gln Phe Thr Pro Asn Trp Asp Ser 
    210                 215                 220                 

Gln Gln Ala Leu Thr Glu Met Gln Gln Ala Leu Thr Arg Leu His Asn 
225                 230                 235                 240 

His Val Asp Ala Val Leu Ala Ala Asn Asp Asn Leu Ala Gly Ala Ala 
                245                 250                 255     

Ile Gln Ala Leu Glu Gln Gln His Ile Lys Gly Ile Pro Val Thr Gly 
            260                 265                 270         

Gln Asp Ala Thr Asp Ala Gly Leu His Arg Ile Tyr Tyr Glu Gly Thr 
        275                 280                 285             

Gln Ser Met Thr Val Tyr Lys Pro Ile Lys Glu Glu Ala Asn Ala Ala 
    290                 295                 300                 

Ala Gln Leu Ala Tyr Asp Leu Ile Thr Gly Lys Lys Pro Pro Ala Ser 
305                 310                 315                 320 

Leu Val Gln Gly Thr Val Asn Asn Gly Ala Thr Asn Val Pro Ser Val 
                325                 330                 335     

Leu Leu Gln Pro Ile Val Val Thr Lys Ser Asn Val Ala Ser Thr Val 
            340                 345                 350         

Ile Lys Asp Gly Phe Thr Thr Trp Ala Arg Ile Lys Asn Pro Ala Glu 
        355                 360                 365             

Gln Gln 
    370 

<210>   723
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   723
Met Ala Lys Lys Thr Trp Lys Lys Ser Ala Thr Trp Met Ala Ala Ala 
                5                   10                  15      

Ala Val Val Thr Gly Ile Val Ala Gly Cys Gly Thr Ser Ser Ala Asn 
            20                  25                  30          

Gly Gln Gly Ser Thr Ser Thr Gly Ala Ala Ser Ala Val Asn Pro His 
        35                  40                  45              

Pro Ser Val Lys Ile Ala Phe Leu Met Pro Glu Thr Asn Thr Ser Pro 
    50                  55                  60                  

Arg Trp Glu Tyr Asp Asp Arg Pro Asp Phe Ile Ala Ala Met Lys Lys 
65                  70                  75                  80  

Leu Asp Pro Asn Ala Gln Ile Ile Tyr Ala Asn Ala Gln Gly Ser Glu 
                85                  90                  95      

Ala Thr Gln Leu Gln Gln Val Glu Ser Ala Ile Thr Glu Gly Ala Lys 
            100                 105                 110         

Leu Leu Val Val Ala Pro Val Asn Gly Phe Ala Ala Thr Thr Ile Val 
        115                 120                 125             

Thr Glu Ala Ala Lys Ala His Val Pro Val Ile Ser Tyr Asp Arg Leu 
    130                 135                 140                 

Ile Gln Asn Ala Lys Val Asp Tyr Tyr Val Ser Phe Asn Asn Val Glu 
145                 150                 155                 160 

Val Gly Lys Leu Gln Gly Glu Tyr Ile Ala Gln His Thr Arg Lys Gly 
                165                 170                 175     

Gly Thr Val Val Met Leu Asp Gly Ala Pro Thr Asp Pro Asn Ala Lys 
            180                 185                 190         

Gln Phe Ala Gln Gly Ala His Asp Val Leu Asp Pro Leu Phe Lys Ser 
        195                 200                 205             

Gly Lys Leu Lys Leu Gly Tyr Glu Gln Phe Thr Pro Asn Trp Asp Ser 
    210                 215                 220                 

Gln Gln Ala Leu Thr Glu Met Gln Gln Ala Leu Thr Arg Leu His Asn 
225                 230                 235                 240 

His Val Asp Ala Val Leu Ala Ala Asn Asp Asn Leu Ala Gly Ala Ala 
                245                 250                 255     

Ile Gln Ala Leu Glu Gln Gln His Ile Lys Gly Ile Pro Val Thr Gly 
            260                 265                 270         

Gln Asp Ala Thr Asp Ala Gly Leu His Arg Ile Tyr Tyr Glu Gly Thr 
        275                 280                 285             

Gln Ser Met Thr Val Tyr Lys Pro Ile Lys Glu Glu Ala Asn Ala Ala 
    290                 295                 300                 

Ala Gln Leu Ala Tyr Asp Leu Ile Thr Gly Lys Lys Pro Pro Ala Ser 
305                 310                 315                 320 

Leu Val Asn Gly Thr Val Asn Asn Gly Ala Thr Asn Val Pro Ser Val 
                325                 330                 335     

Leu Leu Gln Pro Ile Val Val Thr Lys Ser Asn Val Ala Ser Thr Val 
            340                 345                 350         

Ile Lys Asp Gly Phe Thr Thr Trp Ala Arg Ile Lys Asn Pro Ala Glu 
        355                 360                 365             

Gln Gln 
    370 

<210>   724
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   724
Met Ala Lys Lys Thr Trp Lys Lys Ser Ala Thr Trp Met Ala Ala Ala 
                5                   10                  15      

Ala Val Val Thr Gly Ile Val Ala Gly Cys Gly Thr Ser Ser Ala Asn 
            20                  25                  30          

Gly Gln Gly Ser Thr Ser Thr Gly Ala Ala Ser Ala Val Asn Pro His 
        35                  40                  45              

Pro Ser Val Lys Ile Ala Phe Leu Met Pro Glu Thr Asn Thr Ser Pro 
    50                  55                  60                  

Arg Trp Glu Tyr Asp Asp Arg Pro Asp Phe Ile Ala Ala Met Lys Lys 
65                  70                  75                  80  

Leu Asp Pro Asn Ala Gln Ile Ile Tyr Ala Asn Ala Gln Gly Ser Glu 
                85                  90                  95      

Ala Thr Gln Leu Gln Gln Val Glu Ser Ala Ile Thr Glu Gly Ala Lys 
            100                 105                 110         

Leu Leu Val Val Ala Pro Val Asn Gly Phe Ala Ala Thr Thr Ile Val 
        115                 120                 125             

Thr Glu Ala Ala Lys Ala His Val Pro Val Ile Ser Tyr Asp Arg Leu 
    130                 135                 140                 

Ile Gln Asn Ala Lys Val Asp Tyr Tyr Val Ser Phe Asn Asn Val Glu 
145                 150                 155                 160 

Val Gly Lys Leu Gln Gly Glu Tyr Ile Ala Gln His Thr Lys Lys Gly 
                165                 170                 175     

Gly Thr Val Val Met Leu Asp Gly Ala Pro Thr Asp Pro Asn Ala Lys 
            180                 185                 190         

Gln Phe Ala Gln Gly Ala His Asp Val Leu Asp Pro Leu Phe Lys Ser 
        195                 200                 205             

Gly Lys Leu Lys Leu Gly Tyr Glu Gln Phe Thr Pro Asn Trp Asp Ser 
    210                 215                 220                 

Gln Gln Ala Leu Thr Glu Met Gln Gln Ala Leu Thr Arg Leu His Asn 
225                 230                 235                 240 

His Val Asp Ala Val Leu Ala Ala Asn Asp Asn Leu Ala Gly Ala Ala 
                245                 250                 255     

Ile Gln Ala Leu Glu Gln Gln His Leu Lys Gly Ile Pro Val Thr Gly 
            260                 265                 270         

Gln Asp Ala Thr Asp Ala Gly Leu His Arg Ile Tyr Tyr Glu Gly Thr 
        275                 280                 285             

Gln Ser Met Thr Val Tyr Lys Pro Ile Lys Glu Glu Ala Asn Ala Ala 
    290                 295                 300                 

Ala Gln Leu Ala Tyr Asp Leu Ile Thr Gly Lys Lys Pro Pro Ala Ser 
305                 310                 315                 320 

Leu Val Asn Gly Thr Val Asn Asn Gly Ala Thr Asn Val Pro Ser Val 
                325                 330                 335     

Leu Leu Gln Pro Ile Val Val Thr Lys Ser Asn Val Ala Ser Thr Val 
            340                 345                 350         

Ile Lys Asp Gly Phe Thr Thr Trp Ala Arg Ile Lys Asn Pro Ala Glu 
        355                 360                 365             

Gln Gln 
    370 

<210>   725
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   725
Met Ala Lys Lys Thr Trp Lys Lys Ser Ala Thr Trp Met Ala Ala Ala 
                5                   10                  15      

Ala Val Val Thr Gly Ile Val Ala Gly Cys Gly Thr Ser Ser Ala Asn 
            20                  25                  30          

Gly Gln Gly Ser Thr Ser Thr Gly Ala Ala Ser Ala Val Asn Pro His 
        35                  40                  45              

Pro Ser Val Lys Ile Ala Phe Leu Met Pro Glu Thr Asn Thr Ser Pro 
    50                  55                  60                  

Arg Trp Glu Tyr Asp Asp Arg Pro Asp Phe Ile Ala Ala Met Lys Lys 
65                  70                  75                  80  

Leu Asp Pro Asn Ala Gln Ile Ile Tyr Ala Asn Ala Gln Gly Ser Glu 
                85                  90                  95      

Ala Thr Gln Leu Gln Gln Val Glu Ser Ala Ile Thr Glu Gly Ala Lys 
            100                 105                 110         

Leu Leu Val Val Ala Pro Val Asn Gly Phe Ala Ala Thr Thr Ile Val 
        115                 120                 125             

Thr Glu Ala Ala Lys Ala His Val Pro Val Ile Ser Tyr Asp Arg Leu 
    130                 135                 140                 

Ile Gln Asn Ala Lys Val Asp Tyr Tyr Val Ser Phe Asn Asn Val Glu 
145                 150                 155                 160 

Val Gly Lys Leu Gln Gly Glu Tyr Ile Ala Gln His Thr Lys Lys Gly 
                165                 170                 175     

Gly Thr Val Val Met Leu Asp Gly Ala Pro Thr Asp Pro Asn Ala Lys 
            180                 185                 190         

Gln Phe Ala Gln Gly Ala His Asp Val Leu Asp Pro Leu Phe Lys Ser 
        195                 200                 205             

Gly Lys Leu Lys Leu Gly Tyr Glu Gln Phe Thr Pro Asn Trp Asp Ser 
    210                 215                 220                 

Gln Gln Ala Leu Thr Glu Met Gln Gln Ala Leu Thr Arg Leu His Asn 
225                 230                 235                 240 

His Val Asp Ala Val Leu Ala Ala Asn Asp Asn Leu Ala Gly Ala Ala 
                245                 250                 255     

Ile Gln Ala Leu Glu Gln Gln His Ile Lys Gly Ile Pro Val Thr Gly 
            260                 265                 270         

Gln Asp Ala Thr Asp Ala Gly Leu His Arg Ile Tyr Tyr Glu Gly Thr 
        275                 280                 285             

Gln Ser Met Thr Val Tyr Lys Pro Ile Lys Glu Glu Ala Asn Ala Ala 
    290                 295                 300                 

Ala Gln Leu Ala Tyr Asp Leu Leu Thr Gly Lys Lys Pro Pro Ala Ser 
305                 310                 315                 320 

Leu Val Asn Gly Thr Val Asn Asn Gly Ala Thr Asn Val Pro Ser Val 
                325                 330                 335     

Leu Leu Gln Pro Ile Val Val Thr Lys Ser Asn Val Ala Ser Thr Val 
            340                 345                 350         

Ile Lys Asp Gly Phe Thr Thr Trp Ala Arg Ile Lys Asn Pro Ala Glu 
        355                 360                 365             

Gln Gln 
    370 

<210>   726
<211>   370
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 715

<400>   726
Met Ala Lys Lys Thr Trp Lys Lys Ser Ala Thr Trp Met Ala Ala Ala 
                5                   10                  15      

Ala Val Val Thr Gly Ile Val Ala Gly Cys Gly Thr Ser Ser Ala Asn 
            20                  25                  30          

Gly Gln Gly Ser Thr Ser Thr Gly Ala Ala Ser Ala Val Asn Pro His 
        35                  40                  45              

Pro Ser Val Lys Ile Ala Phe Leu Met Pro Glu Thr Asn Thr Ser Pro 
    50                  55                  60                  

Arg Trp Glu Tyr Asp Asp Arg Pro Glu Phe Ile Ala Ala Met Lys Lys 
65                  70                  75                  80  

Leu Asp Pro Asn Ala Gln Ile Ile Tyr Ala Asn Ala Gln Gly Ser Glu 
                85                  90                  95      

Ala Thr Gln Leu Gln Gln Val Glu Ser Ala Ile Thr Glu Gly Ala Lys 
            100                 105                 110         

Leu Leu Val Val Ala Pro Val Asn Gly Phe Ala Ala Thr Thr Ile Val 
        115                 120                 125             

Thr Glu Ala Ala Lys Ala His Val Pro Val Ile Ser Tyr Asp Arg Leu 
    130                 135                 140                 

Ile Gln Asn Ala Lys Val Asp Tyr Tyr Val Ser Phe Asn Asn Val Glu 
145                 150                 155                 160 

Val Gly Lys Leu Gln Gly Glu Tyr Ile Ala Gln His Thr Lys Lys Gly 
                165                 170                 175     

Gly Thr Val Val Met Leu Asp Gly Ala Pro Thr Asp Pro Asn Ala Lys 
            180                 185                 190         

Gln Phe Ala Gln Gly Ala His Asp Val Leu Asp Pro Leu Phe Lys Ser 
        195                 200                 205             

Gly Lys Leu Lys Leu Gly Tyr Glu Gln Phe Thr Pro Asn Trp Asp Ser 
    210                 215                 220                 

Gln Gln Ala Leu Thr Glu Met Gln Gln Ala Leu Thr Arg Leu His Asn 
225                 230                 235                 240 

His Val Asp Ala Val Leu Ala Ala Asn Asp Asn Leu Ala Gly Ala Ala 
                245                 250                 255     

Ile Gln Ala Leu Glu Gln Gln His Ile Lys Gly Ile Pro Val Thr Gly 
            260                 265                 270         

Gln Asp Ala Thr Asp Ala Gly Leu His Arg Ile Tyr Tyr Glu Gly Thr 
        275                 280                 285             

Gln Ser Met Thr Val Tyr Lys Pro Ile Lys Glu Glu Ala Asn Ala Ala 
    290                 295                 300                 

Ala Gln Leu Ala Tyr Asp Leu Ile Thr Gly Lys Lys Pro Pro Ala Ser 
305                 310                 315                 320 

Leu Val Asn Gly Thr Val Asn Asn Gly Ala Thr Asn Val Pro Ser Val 
                325                 330                 335     

Leu Leu Gln Pro Ile Val Val Thr Lys Ser Asn Val Ala Ser Thr Val 
            340                 345                 350         

Ile Lys Asp Gly Phe Thr Thr Trp Ala Arg Ile Lys Asn Pro Ala Glu 
        355                 360                 365             

Gln Gln 
    370 

<210>   727
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   727
gtggccaaga agacatggaa gaagagcgca acgtggatgg cggcggcggc cgtcgtgacg       60

gggattgtcg ctgggtgcgg cacctcttcg gcgaatgggc agggctcgac gtcgacgggc      120

gcggcgtctg cagtgaatcc gcacccgagc gtcaaaatcg cgtttctgat gccggagacg      180

aacacgtcgc cgcgttggga gtacgatgat cgcccggact tcatcgcggc gatgaagaag      240

ctggatccga acgcgcagat catctatgcc aacgcgcagg ggtctgaggc gacgcagctt      300

cagcaggtgg aaagcgccat cacggagggt gcgaagctcc tcgtcgtggc accggtgaac      360

gggtttgcgg ccacgaccat cgtcaccgag gccgcgaaag cgcacgttcc cgtgatctcg      420

tacgatcgcc tcattcagaa cgccaaggtc gactattacg tctcgttcaa caacgtcgag      480

gtcggcaagc ttcagggcga gtacatcgcg cagcacacca agaagggcgg caccgtggtc      540

atgttggacg gcgcgcccac ggatccgaac gcgaagcagt tcgcgcaggg cgcccatgac      600

gtcctggatc cgctctttaa atcgggcaag ctgaagctcg gttatgagca gttcacgccg      660

aactgggatt cgcagcaggc gctgaccgag atgcagcagg cgctcacgcg gctgcacaat      720

cacgtggacg ccgtgctggc tgcgaacgac aacctggcgg gcgcggccat ccaggcgctt      780

gagcagcagc acatcaaggg catccccgtg acaggccagg atgcgaccga cgccggcctg      840

caccggattt attacgaagg cacccagtcg atgacggtgt acaagcccat caaggaagag      900

gccaacgcag cggctcagct ggcgtatgac ctcatcacgg gcaagaagcc gccggcatcg      960

ctcgtgcaag gcacggtgaa caacggtgcc acgaacgtgc cgtccgtgct cctgcagccc     1020

atcgttgtga cgaagtcgaa cgtcgcaagc acggtcatca aggacggctt cacgacctgg     1080

gcgcgcatca agaacccggc agagcagcag taa                                  1113


<210>   728
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   728
gtggccaaga agacatggaa gaagagcgca acgtggatgg cggcggcggc cgtcgtgacg       60

gggattgtcg ctgggtgcgg cacctcttcg gcgaatgggc agggctcgac gtcgacgggc      120

gcggcgtctg cagtgaatcc gcacccgagc gtcaaaatcg cgtttctgat gccggagacg      180

aacacgtcgc cgcgttggga gtacgatgat cgcccggact tcatcgcggc gatgaagaag      240

ctggatccga acgcgcagat catctatgcc aacgcgcagg ggtctgaggc gacgcagctt      300

cagcaggtgg aaagcgccat cacggagggt gcgaagctcc tcgtcgtggc accggtgaac      360

gggtttgcgg ccacgaccat cgtcaccgag gccgcgaaag cgcacgttcc cgtgatctcg      420

tacgatcgcc tcattcagaa cgccaaggtc gactattacg tctcgttcaa caacgtcgag      480

gtcggcaagc ttcagggcga gtacatcgcg cagcacaccc gtaagggcgg caccgtggtc      540

atgttggacg gcgcgcccac ggatccgaac gcgaagcagt tcgcgcaggg cgcccatgac      600

gtcctggatc cgctctttaa atcgggcaag ctgaagctcg gttatgagca gttcacgccg      660

aactgggatt cgcagcaggc gctgaccgag atgcagcagg cgctcacgcg gctgcacaat      720

cacgtggacg ccgtgctggc tgcgaacgac aacctggcgg gcgcggccat ccaggcgctt      780

gagcagcagc acatcaaggg catccccgtg acaggccagg atgcgaccga cgccggcctg      840

caccggattt attacgaagg cacccagtcg atgacggtgt acaagcccat caaggaagag      900

gccaacgcag cggctcagct ggcgtatgac ctcatcacgg gcaagaagcc gccggcatcg      960

ctcgtgaatg gcacggtgaa caacggtgcc acgaacgtgc cgtccgtgct cctgcagccc     1020

atcgttgtga cgaagtcgaa cgtcgcaagc acggtcatca aggacggctt cacgacctgg     1080

gcgcgcatca agaacccggc agagcagcag taa                                  1113


<210>   729
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   729
gtggccaaga agacatggaa gaagagcgca acgtggatgg cggcggcggc cgtcgtgacg       60

gggattgtcg ctgggtgcgg cacctcttcg gcgaatgggc agggctcgac gtcgacgggc      120

gcggcgtctg cagtgaatcc gcacccgagc gtcaaaatcg cgtttctgat gccggagacg      180

aacacgtcgc cgcgttggga gtacgatgat cgcccggact tcatcgcggc gatgaagaag      240

ctggatccga acgcgcagat catctatgcc aacgcgcagg ggtctgaggc gacgcagctt      300

cagcaggtgg aaagcgccat cacggagggt gcgaagctcc tcgtcgtggc accggtgaac      360

gggtttgcgg ccacgaccat cgtcaccgag gccgcgaaag cgcacgttcc cgtgatctcg      420

tacgatcgcc tcattcagaa cgccaaggtc gactattacg tctcgttcaa caacgtcgag      480

gtcggcaagc ttcagggcga gtacatcgcg cagcacacca agaagggcgg caccgtggtc      540

atgttggacg gcgcgcccac ggatccgaac gcgaagcagt tcgcgcaggg cgcccatgac      600

gtcctggatc cgctctttaa atcgggcaag ctgaagctcg gttatgagca gttcacgccg      660

aactgggatt cgcagcaggc gctgaccgag atgcagcagg cgctcacgcg gctgcacaat      720

cacgtggacg ccgtgctggc tgcgaacgac aacctggcgg gcgcggccat ccaggcgctt      780

gagcagcagc acttaaaggg catccccgtg acaggccagg atgcgaccga cgccggcctg      840

caccggattt attacgaagg cacccagtcg atgacggtgt acaagcccat caaggaagag      900

gccaacgcag cggctcagct ggcgtatgac ctcatcacgg gcaagaagcc gccggcatcg      960

ctcgtgaatg gcacggtgaa caacggtgcc acgaacgtgc cgtccgtgct cctgcagccc     1020

atcgttgtga cgaagtcgaa cgtcgcaagc acggtcatca aggacggctt cacgacctgg     1080

gcgcgcatca agaacccggc agagcagcag taa                                  1113


<210>   730
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   730
gtggccaaga agacatggaa gaagagcgca acgtggatgg cggcggcggc cgtcgtgacg       60

gggattgtcg ctgggtgcgg cacctcttcg gcgaatgggc agggctcgac gtcgacgggc      120

gcggcgtctg cagtgaatcc gcacccgagc gtcaaaatcg cgtttctgat gccggagacg      180

aacacgtcgc cgcgttggga gtacgatgat cgcccggact tcatcgcggc gatgaagaag      240

ctggatccga acgcgcagat catctatgcc aacgcgcagg ggtctgaggc gacgcagctt      300

cagcaggtgg aaagcgccat cacggagggt gcgaagctcc tcgtcgtggc accggtgaac      360

gggtttgcgg ccacgaccat cgtcaccgag gccgcgaaag cgcacgttcc cgtgatctcg      420

tacgatcgcc tcattcagaa cgccaaggtc gactattacg tctcgttcaa caacgtcgag      480

gtcggcaagc ttcagggcga gtacatcgcg cagcacacca agaagggcgg caccgtggtc      540

atgttggacg gcgcgcccac ggatccgaac gcgaagcagt tcgcgcaggg cgcccatgac      600

gtcctggatc cgctctttaa atcgggcaag ctgaagctcg gttatgagca gttcacgccg      660

aactgggatt cgcagcaggc gctgaccgag atgcagcagg cgctcacgcg gctgcacaat      720

cacgtggacg ccgtgctggc tgcgaacgac aacctggcgg gcgcggccat ccaggcgctt      780

gagcagcagc acatcaaggg catccccgtg acaggccagg atgcgaccga cgccggcctg      840

caccggattt attacgaagg cacccagtcg atgacggtgt acaagcccat caaggaagag      900

gccaacgcag cggctcagct ggcgtatgac ctcttaacgg gcaagaagcc gccggcatcg      960

ctcgtgaatg gcacggtgaa caacggtgcc acgaacgtgc cgtccgtgct cctgcagccc     1020

atcgttgtga cgaagtcgaa cgtcgcaagc acggtcatca aggacggctt cacgacctgg     1080

gcgcgcatca agaacccggc agagcagcag taa                                  1113


<210>   731
<211>   1113
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 716

<400>   731
gtggccaaga agacatggaa gaagagcgca acgtggatgg cggcggcggc cgtcgtgacg       60

gggattgtcg ctgggtgcgg cacctcttcg gcgaatgggc agggctcgac gtcgacgggc      120

gcggcgtctg cagtgaatcc gcacccgagc gtcaaaatcg cgtttctgat gccggagacg      180

aacacgtcgc cgcgttggga gtacgatgat cgcccggaat tcatcgcggc gatgaagaag      240

ctggatccga acgcgcagat catctatgcc aacgcgcagg ggtctgaggc gacgcagctt      300

cagcaggtgg aaagcgccat cacggagggt gcgaagctcc tcgtcgtggc accggtgaac      360

gggtttgcgg ccacgaccat cgtcaccgag gccgcgaaag cgcacgttcc cgtgatctcg      420

tacgatcgcc tcattcagaa cgccaaggtc gactattacg tctcgttcaa caacgtcgag      480

gtcggcaagc ttcagggcga gtacatcgcg cagcacacca agaagggcgg caccgtggtc      540

atgttggacg gcgcgcccac ggatccgaac gcgaagcagt tcgcgcaggg cgcccatgac      600

gtcctggatc cgctctttaa atcgggcaag ctgaagctcg gttatgagca gttcacgccg      660

aactgggatt cgcagcaggc gctgaccgag atgcagcagg cgctcacgcg gctgcacaat      720

cacgtggacg ccgtgctggc tgcgaacgac aacctggcgg gcgcggccat ccaggcgctt      780

gagcagcagc acatcaaggg catccccgtg acaggccagg atgcgaccga cgccggcctg      840

caccggattt attacgaagg cacccagtcg atgacggtgt acaagcccat caaggaagag      900

gccaacgcag cggctcagct ggcgtatgac ctcatcacgg gcaagaagcc gccggcatcg      960

ctcgtgaatg gcacggtgaa caacggtgcc acgaacgtgc cgtccgtgct cctgcagccc     1020

atcgttgtga cgaagtcgaa cgtcgcaagc acggtcatca aggacggctt cacgacctgg     1080

gcgcgcatca agaacccggc agagcagcag taa                                  1113


<210>   732
<211>   260
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   732
Met Ala Thr Glu Val Lys Thr Gln Pro Val Leu Glu Val Arg Ser Leu 
                5                   10                  15      

Arg Lys Arg Phe Gly Ala Val Gln Ala Leu Asp Gly Val Ser Phe Ser 
            20                  25                  30          

Val His Ala Gly Glu Ile Val Ala Leu Val Gly Asp Asn Gly Ala Gly 
        35                  40                  45              

Lys Ser Thr Thr Ile Lys Met Ile Ala Gly Val Glu Gln Pro Asp Glu 
    50                  55                  60                  

Gly Glu Ile Leu Phe Glu Gly Gln Pro Val Arg Leu Thr Ser Pro Ala 
65                  70                  75                  80  

Val Ala Glu Lys Tyr Gly Ile Gln Thr Val Tyr Gln Asp Leu Ala Leu 
                85                  90                  95      

Cys Asp Asn Leu Asp Ile Val Ser Asn Leu Phe Leu Gly Arg Glu Leu 
            100                 105                 110         

Arg Arg Ser Val Ile Pro Gly Leu Val Arg Val Ile Asp Arg Asn Glu 
        115                 120                 125             

Met Glu Arg Arg Ala Ile Pro Val Leu Asn Glu Leu Gly Ile Arg Leu 
    130                 135                 140                 

Pro Pro Leu His Thr Gln Val Ala Ser Leu Ser Gly Gly Gln Arg Gln 
145                 150                 155                 160 

Thr Val Ala Val Ala Arg Ser Val Leu Trp Gly Ser Lys Leu Val Met 
                165                 170                 175     

Leu Asp Glu Pro Thr Ala Ala Leu Gly Val Val Gln Gln Arg Ala Val 
            180                 185                 190         

Leu Glu Leu Ile Gln Arg Leu Ala Ala Ser Gly Arg Ala Val Leu Val 
        195                 200                 205             

Ile Ser His Asn Met Ser Asp Val Phe Lys Ile Ala Asn Arg Ile Val 
    210                 215                 220                 

Val Leu Arg Leu Gly Arg Thr Val Ala Thr Phe Asp Arg Glu Gln Val 
225                 230                 235                 240 

Thr Pro Glu Gln Val Val Ala Ala Ile Thr Gly Ala Ser Ala Gln Glu 
                245                 250                 255     

Glu Val Thr Ser 
            260 

<210>   733
<211>   783
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   733
gtggcaacgg aggtcaagac acagccggtc ctcgaggtgc gcagccttcg caagcgattt       60

ggcgccgttc aggcgttgga cggtgtttcg ttttccgtgc atgcaggcga aatcgtggcg      120

ctcgtcgggg acaacggcgc cggtaagtcg accaccatca agatgatcgc gggtgtcgag      180

cagccggacg aaggagagat cttgttcgag ggccagccgg tccgcctgac gagtccagcc      240

gtggcagaaa agtacggcat tcagacggtc taccaggacc tcgcgctctg tgacaacctg      300

gacatcgtct cgaacctgtt tctcggccgg gagctgcggc gcagcgtgat tcccgggctg      360

gtgcgcgtga tcgaccggaa cgagatggag cggcgcgcca tccctgtgct gaacgaactt      420

gggattcgcc tgcccccatt gcacacgcag gtcgcatcgc tctccggtgg tcaacgccag      480

acggtcgctg tggcgcgatc cgtcctgtgg ggttcgaaac tcgtcatgct cgatgagccg      540

accgctgcgc tcggcgtcgt gcagcagcgc gcggtgcttg agctcatcca gaggcttgca      600

gcgagcggcc gcgcggtgct cgtcatctcg cacaacatga gcgacgtgtt taaaattgcc      660

aaccgcatcg tggtgctgcg gttggggcga accgtggcga cgttcgatcg ggagcaagtc      720

acgcccgagc aggttgtggc ggccatcacg ggcgcatcgg cgcaagagga ggtcacgtcc      780

taa                                                                    783


<210>   734
<211>   250
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   734
Ala Thr Glu Ala Ala Met Pro Val Leu Gln Leu Arg Gln Ile Ser Lys 
                5                   10                  15      

Arg Phe Gly Ala Val Gln Ala Leu Ser Asn Val Asp Phe Glu Val Tyr 
            20                  25                  30          

Ser Asn Glu Val Val Ala Leu Val Gly Asp Asn Gly Ala Gly Lys Ser 
        35                  40                  45              

Thr Leu Ile Lys Thr Ile Ala Gly Ala Tyr Lys Pro Asp Glu Gly Asp 
    50                  55                  60                  

Tyr Val Phe Glu Gly Lys Val Val Ser Ile Asn Ser Pro Arg Asp Ala 
65                  70                  75                  80  

Thr Asp Leu Gly Val Glu Thr Val Tyr Gln Asp Leu Ala Leu Cys Asp 
                85                  90                  95      

Asn Leu Asp Val Val Ser Asn Leu Tyr Leu Gly Arg Glu Asn Val Arg 
            100                 105                 110         

Arg Ser Gly Leu Lys Ser Phe Asp Leu Leu Asn Glu Thr Glu Met Glu 
        115                 120                 125             

Arg Arg Ala Thr Glu Val Leu Arg Asp Leu Ser Val Lys Ile Pro Ser 
    130                 135                 140                 

Val Arg Val Gln Ile Ala Asn Leu Ser Gly Gly Gln Arg Gln Ser Val 
145                 150                 155                 160 

Ala Val Ala Arg Ser Val Met Trp Asn Ser Lys Val Val Leu Leu Asp 
                165                 170                 175     

Glu Pro Thr Ala Ala Leu Gly Val Glu Gln Thr Arg Gln Val Lys Asp 
            180                 185                 190         

Leu Ile Met Arg Leu Arg Asp Arg Gly Leu Ala Val Val Val Ile Ser 
        195                 200                 205             

His Asn Val Ala Asp Val Phe Glu Val Ser Asp Arg Ile Ile Val Met 
    210                 215                 220                 

Arg Leu Gly Arg Arg Val Ala Thr Phe His Thr Ala Arg Ser Thr Asn 
225                 230                 235                 240 

Glu Gln Val Ile Gly Ala Ile Thr Gly Ala 
                245                 250 

<210>   735
<211>   255
<212>   PRT
<213>   Plectonema boryanum

<400>   735
Ala Ser Ser Ser Ser Thr Arg Pro Thr Leu Glu Leu Arg Asn Ile Cys 
                5                   10                  15      

Lys Ser Phe Gly Gly Val Gln Ala Leu Lys Asn Val Asp Phe Glu Val 
            20                  25                  30          

Tyr Ala Gly Glu Val Val Gly Leu Val Gly Asp Asn Gly Ala Gly Lys 
        35                  40                  45              

Ser Thr Leu Val Lys Thr Met Ser Gly Ala Tyr Val Pro Asp Ser Gly 
    50                  55                  60                  

Glu Ile Phe Leu Asn Gly Glu Arg Val Ser Ile Ala Ser Pro Gln Asp 
65                  70                  75                  80  

Ala Thr Arg Leu Gly Ile Glu Thr Val Tyr Gln Asp Leu Ala Leu Cys 
                85                  90                  95      

Asp Asn Leu Asp Val Val Gly Asn Leu Trp Leu Gly Arg Glu Ala Tyr 
            100                 105                 110         

Arg Trp Leu Ile Pro Gly Val Leu Lys Val Leu Asp Glu Thr Glu Met 
        115                 120                 125             

Glu Arg Arg Thr Ile Glu Val Leu Lys Leu Leu Asp Val Lys Ile Pro 
    130                 135                 140                 

Ser Val Arg Arg Pro Val Ala Ala Leu Ser Gly Gly Gln Arg Gln Cys 
145                 150                 155                 160 

Ile Ala Val Ala Lys Thr Ile Leu Arg Ser Pro Lys Val Val Leu Leu 
                165                 170                 175     

Asp Glu Pro Thr Ala Ala Leu Gly Val Ala Gln Thr Arg Gln Val Leu 
            180                 185                 190         

Asn Leu Ile Gln Arg Leu Lys Gln Gln Gly Leu Ala Val Val Val Ile 
        195                 200                 205             

Ser His Asn Leu His Asp Val Phe Glu Val Cys Asp Arg Val Ile Val 
    210                 215                 220                 

Met Arg Leu Gly Gln Arg Ser Ala Thr Phe Asp Ile Gln Ser Ser Thr 
225                 230                 235                 240 

Ser Glu Gln Val Val Ala Ala Ile Thr Gly Ala Glu Tyr Arg Asp 
                245                 250                 255 

<210>   736
<211>   254
<212>   PRT
<213>   Acidiphilium cryptum JF-5

<400>   736
Ile Ala Ala Glu Pro Ala Ala Ala Pro Leu Leu Glu Val Arg Gly Leu 
                5                   10                  15      

Gln Lys Arg Tyr Gly Ala Val Val Ala Leu Arg Asp Val Asn Phe Thr 
            20                  25                  30          

Val Arg Arg Gly Glu Val Thr Ala Leu Leu Gly Asp Asn Gly Ala Gly 
        35                  40                  45              

Lys Ser Thr Thr Ile Lys Ala Ile Ala Gly Val Ala Pro Ile Asp Glu 
    50                  55                  60                  

Gly Glu Ile Leu Leu Glu Gly Arg Pro Val Ser Ile Arg His Pro Ser 
65                  70                  75                  80  

Glu Ala Thr Ala Leu Gly Ile Gln Thr Val Tyr Gln Asp Leu Ala Leu 
                85                  90                  95      

Cys Asp Asn Leu Gly Ile Cys Ala Asn Leu Tyr Leu Gly Arg Glu Leu 
            100                 105                 110         

Val Ser Thr Pro Thr Ala Leu Gly Pro His Val Leu Arg Asp Val Asp 
        115                 120                 125             

Met Glu Leu Glu Ala Arg Arg Val Leu Lys Thr Leu Arg Ile Asn Leu 
    130                 135                 140                 

Pro Ala Leu Asp Thr Pro Val Ala Ser Leu Ser Gly Gly Gln Arg Gln 
145                 150                 155                 160 

Ala Val Ala Ile Ala Arg Ala Val Leu Trp Asp Ser Lys Leu Val Ile 
                165                 170                 175     

Met Asp Glu Pro Thr Ala Ala Leu Gly Val Ala Gln Thr Ala Glu Val 
            180                 185                 190         

Leu Arg Leu Val Arg Asp Leu Ala Glu Gln Gly Tyr Gly Val Ile Leu 
        195                 200                 205             

Ile Thr His Asn Met Gln Asn Val Phe Gln Val Ala Asp Asn Ile Ala 
    210                 215                 220                 

Val Leu Arg Leu Gly Ala Thr Val Met Glu Ala Arg Lys Ser Asp Val 
225                 230                 235                 240 

Thr Pro Glu Gln Val Val Gly Ala Ile Thr Gly Thr Leu Ala 
                245                 250                 

<210>   737
<211>   240
<212>   PRT
<213>   Thermobifida fusca YX

<400>   737
Gln Pro Ile Leu Glu Leu Ser Gly Ile Ser Lys Arg Phe Gly Ala Val 
                5                   10                  15      

Gln Ala Leu Ser Asp Val Asp Leu Thr Val His Ala Gly Glu Val Val 
            20                  25                  30          

Ala Leu Leu Gly Asp Asn Gly Ala Gly Lys Ser Thr Leu Val Lys Val 
        35                  40                  45              

Ile Ala Gly Val Asn Pro Ala Asp Ser Gly Thr Ile Leu Trp Glu Gly 
    50                  55                  60                  

Lys Pro Val Gln Ile Asn Arg Pro Ser Asp Ala Gln Gln Leu Gly Ile 
65                  70                  75                  80  

Ala Thr Ile Tyr Gln Asp Leu Ala Leu Cys Asp Asn Leu Asp Ile Val 
                85                  90                  95      

Ala Asn Leu Phe Leu Gly Thr Glu Arg Thr Ala Leu Gly Val Leu Asp 
            100                 105                 110         

Glu Leu Glu Met Glu Arg Arg Ala His Glu Leu Leu Asp Ser Leu Ser 
        115                 120                 125             

Val Arg Ile Pro Asn Leu Arg Ile Pro Val Ala Ala Leu Ser Gly Gly 
    130                 135                 140                 

Gln Arg Gln Ile Ile Ala Ile Ala Arg Ser Leu Leu Gly Asp Pro Lys 
145                 150                 155                 160 

Val Val Met Leu Asp Glu Pro Thr Ala Ala Leu Gly Val Ala Gln Thr 
                165                 170                 175     

Ala Gln Val Leu Asp Leu Ile Glu Arg Leu Arg Asp Gln Gly Leu Gly 
            180                 185                 190         

Val Ile Leu Ile Ser His Asn Met Ala Asp Val Arg Ala Val Ala Asp 
        195                 200                 205             

Arg Ala Val Val Leu Arg Leu Gly Arg Asn Ala Gly Asp Phe Arg Ile 
    210                 215                 220                 

Glu Asp Thr Ser Tyr Glu Glu Ile Val Ala Ala Ile Thr Gly Ala Ala 
225                 230                 235                 240 

<210>   738
<211>   243
<212>   PRT
<213>   Streptomyces avermitilis MA-4680

<400>   738
Val Ser Ala Thr Pro Val Leu Ala Leu Arg Gly Val Ser Lys Arg Phe 
                5                   10                  15      

Gly Ala Val Gln Ala Leu Thr Asp Val Glu Leu Glu Ile His Ala Gly 
            20                  25                  30          

Glu Val Val Ala Leu Val Gly Asp Asn Gly Ala Gly Lys Ser Thr Leu 
        35                  40                  45              

Val Lys Thr Ile Ala Gly Val His Pro Ile Asp Glu Gly Val Ile Glu 
    50                  55                  60                  

Trp Asp Gly Lys Ala Val Gln Ile Asn Lys Pro His Asp Ala Gln Asn 
65                  70                  75                  80  

Leu Gly Ile Ala Thr Val Tyr Gln Asp Leu Ala Leu Cys Asp Asn Ile 
                85                  90                  95      

Asp Val Val Gly Asn Leu Tyr Leu Gly Arg Glu Leu Arg Lys Arg Gly 
            100                 105                 110         

Ile Leu Asp Glu Val Glu Met Glu Arg Arg Ser Arg Glu Leu Leu Thr 
        115                 120                 125             

Thr Leu Ser Ile Arg Ile Pro Ser Val Arg Ile Pro Ile Ala Ser Leu 
    130                 135                 140                 

Ser Gly Gly Gln Arg Gln Thr Val Ala Ile Ala Arg Ser Met Leu Gly 
145                 150                 155                 160 

Glu Pro Lys Leu Val Ile Leu Asp Glu Pro Thr Ala Ala Leu Gly Val 
                165                 170                 175     

Glu Gln Thr Ala Gln Val Leu Asp Leu Val Glu Arg Leu Arg Glu Arg 
            180                 185                 190         

Gly His Ala Val Ile Leu Ile Ser His Asn Met Ala Asp Val Lys Ala 
        195                 200                 205             

Val Ala Asp Lys Val Ala Val Leu Arg Leu Gly Arg Asn Asn Gly Val 
    210                 215                 220                 

Phe Glu Val Lys Ser Thr Ser Gln Glu Glu Ile Ile Ser Ala Ile Thr 
225                 230                 235                 240 

Gly Ala Thr 
            

<210>   739
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   739
Met Ala Thr Glu Val Arg Thr Gln Pro Val Leu Glu Val Arg Ser Leu 
                5                   10                  15      

Arg Lys Arg Phe Gly Ala Val Gln Ala Leu Asp Gly Val Ser Phe Ser 
            20                  25                  30          

Val His Ala Gly Glu Ile Val Ala Leu Val Gly Asp Asn Gly Ala Gly 
        35                  40                  45              

Lys Ser Thr Thr Ile Lys Met Ile Ala Gly Val Glu Gln Pro Asp Glu 
    50                  55                  60                  

Gly Glu Ile Leu Phe Glu Gly Gln Pro Val Arg Leu Thr Ser Pro Ala 
65                  70                  75                  80  

Val Ala Glu Lys Tyr Gly Ile Gln Thr Val Tyr Gln Asp Leu Ala Leu 
                85                  90                  95      

Cys Asp Asn Leu Asp Ile Val Ser Asn Leu Phe Leu Gly Arg Glu Leu 
            100                 105                 110         

Arg Arg Ser Val Ile Pro Gly Leu Val Arg Val Ile Asp Arg Asn Glu 
        115                 120                 125             

Met Glu Arg Arg Ala Ile Pro Val Leu Asn Glu Leu Gly Ile Arg Leu 
    130                 135                 140                 

Pro Pro Leu His Thr Gln Val Ala Ser Leu Ser Gly Gly Gln Arg Gln 
145                 150                 155                 160 

Thr Val Ala Val Ala Arg Ser Val Leu Trp Gly Ser Lys Leu Val Met 
                165                 170                 175     

Leu Asp Glu Pro Thr Ala Ala Leu Gly Val Val Gln Gln Arg Ala Val 
            180                 185                 190         

Leu Glu Leu Ile Gln Arg Leu Ala Ala Ser Gly Arg Ala Val Leu Val 
        195                 200                 205             

Ile Ser His Asn Met Ser Asp Val Phe Lys Ile Ala Asn Arg Ile Val 
    210                 215                 220                 

Val Leu Arg Leu Gly Arg Thr Val Ala Thr Phe Asp Arg Glu Gln Val 
225                 230                 235                 240 

Thr Pro Glu Gln Val Val Ala Ala Ile Thr Gly Ala Ser Ala Gln Glu 
                245                 250                 255     

Glu Val Thr Ser 
            260 

<210>   740
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   740
Met Ala Thr Glu Val Lys Thr Gln Pro Val Leu Glu Val Arg Ser Leu 
                5                   10                  15      

Arg Lys Arg Phe Gly Ala Val Gln Ala Leu Asp Gly Val Ser Phe Ser 
            20                  25                  30          

Val His Ala Gly Glu Ile Val Ala Leu Val Gly Asp Asn Gly Ala Gly 
        35                  40                  45              

Lys Ser Thr Thr Ile Lys Met Ile Ala Gly Val Glu Gln Pro Asp Glu 
    50                  55                  60                  

Gly Glu Ile Leu Phe Glu Gly Gln Pro Val Arg Leu Thr Ser Pro Ala 
65                  70                  75                  80  

Val Ala Glu Lys Tyr Gly Ile Gln Thr Val Tyr Gln Asp Leu Ala Leu 
                85                  90                  95      

Cys Asp Asn Leu Asp Ile Val Ser Asn Leu Phe Leu Gly Arg Glu Leu 
            100                 105                 110         

Arg Arg Ser Val Leu Pro Gly Leu Val Arg Val Ile Asp Arg Asn Glu 
        115                 120                 125             

Met Glu Arg Arg Ala Ile Pro Val Leu Asn Glu Leu Gly Ile Arg Leu 
    130                 135                 140                 

Pro Pro Leu His Thr Gln Val Ala Ser Leu Ser Gly Gly Gln Arg Gln 
145                 150                 155                 160 

Thr Val Ala Val Ala Arg Ser Val Leu Trp Gly Ser Lys Leu Val Met 
                165                 170                 175     

Leu Asp Glu Pro Thr Ala Ala Leu Gly Val Val Gln Gln Arg Ala Val 
            180                 185                 190         

Leu Glu Leu Ile Gln Arg Leu Ala Ala Ser Gly Arg Ala Val Leu Val 
        195                 200                 205             

Ile Ser His Asn Met Ser Asp Val Phe Lys Ile Ala Asn Arg Ile Val 
    210                 215                 220                 

Val Leu Arg Leu Gly Arg Thr Val Ala Thr Phe Asp Arg Glu Gln Val 
225                 230                 235                 240 

Thr Pro Glu Gln Val Val Ala Ala Ile Thr Gly Ala Ser Ala Gln Glu 
                245                 250                 255     

Glu Val Thr Ser 
            260 

<210>   741
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   741
Met Ala Thr Glu Val Lys Thr Gln Pro Val Leu Glu Val Arg Ser Leu 
                5                   10                  15      

Arg Lys Arg Phe Gly Ala Val Gln Ala Leu Asp Gly Val Ser Phe Ser 
            20                  25                  30          

Val His Ala Gly Glu Ile Val Ala Leu Val Gly Asp Asn Gly Ala Gly 
        35                  40                  45              

Lys Ser Thr Thr Ile Lys Met Ile Ala Gly Val Glu Gln Pro Asp Glu 
    50                  55                  60                  

Gly Glu Ile Leu Phe Glu Gly Asn Pro Val Arg Leu Thr Ser Pro Ala 
65                  70                  75                  80  

Val Ala Glu Lys Tyr Gly Ile Gln Thr Val Tyr Gln Asp Leu Ala Leu 
                85                  90                  95      

Cys Asp Asn Leu Asp Ile Val Ser Asn Leu Phe Leu Gly Arg Glu Leu 
            100                 105                 110         

Arg Arg Ser Val Ile Pro Gly Leu Val Arg Val Ile Asp Arg Asn Glu 
        115                 120                 125             

Met Glu Arg Arg Ala Ile Pro Val Leu Asn Glu Leu Gly Ile Arg Leu 
    130                 135                 140                 

Pro Pro Leu His Thr Gln Val Ala Ser Leu Ser Gly Gly Gln Arg Gln 
145                 150                 155                 160 

Thr Val Ala Val Ala Arg Ser Val Leu Trp Gly Ser Lys Leu Val Met 
                165                 170                 175     

Leu Asp Glu Pro Thr Ala Ala Leu Gly Val Val Gln Gln Arg Ala Val 
            180                 185                 190         

Leu Glu Leu Ile Gln Arg Leu Ala Ala Ser Gly Arg Ala Val Leu Val 
        195                 200                 205             

Ile Ser His Asn Met Ser Asp Val Phe Lys Ile Ala Asn Arg Ile Val 
    210                 215                 220                 

Val Leu Arg Leu Gly Arg Thr Val Ala Thr Phe Asp Arg Glu Gln Val 
225                 230                 235                 240 

Thr Pro Glu Gln Val Val Ala Ala Ile Thr Gly Ala Ser Ala Gln Glu 
                245                 250                 255     

Glu Val Thr Ser 
            260 

<210>   742
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   742
Met Ala Thr Glu Val Lys Thr Gln Pro Val Leu Glu Val Arg Ser Leu 
                5                   10                  15      

Arg Lys Arg Phe Gly Ala Val Gln Ala Leu Asp Gly Val Ser Phe Ser 
            20                  25                  30          

Val His Ala Gly Glu Ile Ile Ala Leu Val Gly Asp Asn Gly Ala Gly 
        35                  40                  45              

Lys Ser Thr Thr Ile Lys Met Ile Ala Gly Val Glu Gln Pro Asp Glu 
    50                  55                  60                  

Gly Glu Ile Leu Phe Glu Gly Gln Pro Val Arg Leu Thr Ser Pro Ala 
65                  70                  75                  80  

Val Ala Glu Lys Tyr Gly Ile Gln Thr Val Tyr Gln Asp Leu Ala Leu 
                85                  90                  95      

Cys Asp Asn Leu Asp Ile Val Ser Asn Leu Phe Leu Gly Arg Glu Leu 
            100                 105                 110         

Arg Arg Ser Val Ile Pro Gly Leu Val Arg Val Ile Asp Arg Asn Glu 
        115                 120                 125             

Met Glu Arg Arg Ala Ile Pro Val Leu Asn Glu Leu Gly Ile Arg Leu 
    130                 135                 140                 

Pro Pro Leu His Thr Gln Val Ala Ser Leu Ser Gly Gly Gln Arg Gln 
145                 150                 155                 160 

Thr Val Ala Val Ala Arg Ser Val Leu Trp Gly Ser Lys Leu Val Met 
                165                 170                 175     

Leu Asp Glu Pro Thr Ala Ala Leu Gly Val Val Gln Gln Arg Ala Val 
            180                 185                 190         

Leu Glu Leu Ile Gln Arg Leu Ala Ala Ser Gly Arg Ala Val Leu Val 
        195                 200                 205             

Ile Ser His Asn Met Ser Asp Val Phe Lys Ile Ala Asn Arg Ile Val 
    210                 215                 220                 

Val Leu Arg Leu Gly Arg Thr Val Ala Thr Phe Asp Arg Glu Gln Val 
225                 230                 235                 240 

Thr Pro Glu Gln Val Val Ala Ala Ile Thr Gly Ala Ser Ala Gln Glu 
                245                 250                 255     

Glu Val Thr Ser 
            260 

<210>   743
<211>   260
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 732

<400>   743
Met Ala Thr Glu Val Lys Thr Gln Pro Val Leu Glu Val Arg Ser Leu 
                5                   10                  15      

Arg Lys Arg Phe Gly Ala Val Gln Ala Leu Asp Gly Val Ser Phe Ser 
            20                  25                  30          

Val His Ala Gly Glu Ile Val Ala Leu Val Gly Asp Asn Gly Ala Gly 
        35                  40                  45              

Lys Ser Thr Thr Ile Lys Met Ile Ala Gly Val Glu Gln Pro Asp Glu 
    50                  55                  60                  

Gly Glu Ile Leu Phe Glu Gly Gln Pro Val Arg Leu Thr Ser Pro Ala 
65                  70                  75                  80  

Val Ala Glu Lys Tyr Gly Ile Gln Thr Val Tyr Gln Asp Leu Ala Leu 
                85                  90                  95      

Cys Asp Asn Leu Asp Ile Val Ser Asn Leu Phe Leu Gly Arg Glu Leu 
            100                 105                 110         

Arg Arg Ser Val Ile Pro Gly Leu Val Arg Val Ile Asp Arg Asn Glu 
        115                 120                 125             

Met Glu Arg Arg Ala Ile Pro Val Leu Asn Glu Leu Gly Ile Arg Leu 
    130                 135                 140                 

Pro Pro Leu His Thr Gln Val Ala Ser Leu Ser Gly Gly Gln Arg Gln 
145                 150                 155                 160 

Thr Val Ala Val Ala Arg Ser Val Leu Trp Gly Ser Lys Leu Val Met 
                165                 170                 175     

Leu Asp Glu Pro Thr Ala Ala Leu Gly Val Val Gln Gln Arg Ala Val 
            180                 185                 190         

Leu Glu Leu Leu Gln Arg Leu Ala Ala Ser Gly Arg Ala Val Leu Val 
        195                 200                 205             

Ile Ser His Asn Met Ser Asp Val Phe Lys Ile Ala Asn Arg Ile Val 
    210                 215                 220                 

Val Leu Arg Leu Gly Arg Thr Val Ala Thr Phe Asp Arg Glu Gln Val 
225                 230                 235                 240 

Thr Pro Glu Gln Val Val Ala Ala Ile Thr Gly Ala Ser Ala Gln Glu 
                245                 250                 255     

Glu Val Thr Ser 
            260 

<210>   744
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   744
gtggcaacgg aggtccgtac acagccggtc ctcgaggtgc gcagccttcg caagcgattt       60

ggcgccgttc aggcgttgga cggtgtttcg ttttccgtgc atgcaggcga aatcgtggcg      120

ctcgtcgggg acaacggcgc cggtaagtcg accaccatca agatgatcgc gggtgtcgag      180

cagccggacg aaggagagat cttgttcgag ggccagccgg tccgcctgac gagtccagcc      240

gtggcagaaa agtacggcat tcagacggtc taccaggacc tcgcgctctg tgacaacctg      300

gacatcgtct cgaacctgtt tctcggccgg gagctgcggc gcagcgtgat tcccgggctg      360

gtgcgcgtga tcgaccggaa cgagatggag cggcgcgcca tccctgtgct gaacgaactt      420

gggattcgcc tgcccccatt gcacacgcag gtcgcatcgc tctccggtgg tcaacgccag      480

acggtcgctg tggcgcgatc cgtcctgtgg ggttcgaaac tcgtcatgct cgatgagccg      540

accgctgcgc tcggcgtcgt gcagcagcgc gcggtgcttg agctcatcca gaggcttgca      600

gcgagcggcc gcgcggtgct cgtcatctcg cacaacatga gcgacgtgtt taaaattgcc      660

aaccgcatcg tggtgctgcg gttggggcga accgtggcga cgttcgatcg ggagcaagtc      720

acgcccgagc aggttgtggc ggccatcacg ggcgcatcgg cgcaagagga ggtcacgtcc      780

taa                                                                    783


<210>   745
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   745
gtggcaacgg aggtcaagac acagccggtc ctcgaggtgc gcagccttcg caagcgattt       60

ggcgccgttc aggcgttgga cggtgtttcg ttttccgtgc atgcaggcga aatcgtggcg      120

ctcgtcgggg acaacggcgc cggtaagtcg accaccatca agatgatcgc gggtgtcgag      180

cagccggacg aaggagagat cttgttcgag ggccagccgg tccgcctgac gagtccagcc      240

gtggcagaaa agtacggcat tcagacggtc taccaggacc tcgcgctctg tgacaacctg      300

gacatcgtct cgaacctgtt tctcggccgg gagctgcggc gcagcgtgtt acccgggctg      360

gtgcgcgtga tcgaccggaa cgagatggag cggcgcgcca tccctgtgct gaacgaactt      420

gggattcgcc tgcccccatt gcacacgcag gtcgcatcgc tctccggtgg tcaacgccag      480

acggtcgctg tggcgcgatc cgtcctgtgg ggttcgaaac tcgtcatgct cgatgagccg      540

accgctgcgc tcggcgtcgt gcagcagcgc gcggtgcttg agctcatcca gaggcttgca      600

gcgagcggcc gcgcggtgct cgtcatctcg cacaacatga gcgacgtgtt taaaattgcc      660

aaccgcatcg tggtgctgcg gttggggcga accgtggcga cgttcgatcg ggagcaagtc      720

acgcccgagc aggttgtggc ggccatcacg ggcgcatcgg cgcaagagga ggtcacgtcc      780

taa                                                                    783


<210>   746
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   746
gtggcaacgg aggtcaagac acagccggtc ctcgaggtgc gcagccttcg caagcgattt       60

ggcgccgttc aggcgttgga cggtgtttcg ttttccgtgc atgcaggcga aatcgtggcg      120

ctcgtcgggg acaacggcgc cggtaagtcg accaccatca agatgatcgc gggtgtcgag      180

cagccggacg aaggagagat cttgttcgag ggcaatccgg tccgcctgac gagtccagcc      240

gtggcagaaa agtacggcat tcagacggtc taccaggacc tcgcgctctg tgacaacctg      300

gacatcgtct cgaacctgtt tctcggccgg gagctgcggc gcagcgtgat tcccgggctg      360

gtgcgcgtga tcgaccggaa cgagatggag cggcgcgcca tccctgtgct gaacgaactt      420

gggattcgcc tgcccccatt gcacacgcag gtcgcatcgc tctccggtgg tcaacgccag      480

acggtcgctg tggcgcgatc cgtcctgtgg ggttcgaaac tcgtcatgct cgatgagccg      540

accgctgcgc tcggcgtcgt gcagcagcgc gcggtgcttg agctcatcca gaggcttgca      600

gcgagcggcc gcgcggtgct cgtcatctcg cacaacatga gcgacgtgtt taaaattgcc      660

aaccgcatcg tggtgctgcg gttggggcga accgtggcga cgttcgatcg ggagcaagtc      720

acgcccgagc aggttgtggc ggccatcacg ggcgcatcgg cgcaagagga ggtcacgtcc      780

taa                                                                    783


<210>   747
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   747
gtggcaacgg aggtcaagac acagccggtc ctcgaggtgc gcagccttcg caagcgattt       60

ggcgccgttc aggcgttgga cggtgtttcg ttttccgtgc atgcaggcga aatcattgcg      120

ctcgtcgggg acaacggcgc cggtaagtcg accaccatca agatgatcgc gggtgtcgag      180

cagccggacg aaggagagat cttgttcgag ggccagccgg tccgcctgac gagtccagcc      240

gtggcagaaa agtacggcat tcagacggtc taccaggacc tcgcgctctg tgacaacctg      300

gacatcgtct cgaacctgtt tctcggccgg gagctgcggc gcagcgtgat tcccgggctg      360

gtgcgcgtga tcgaccggaa cgagatggag cggcgcgcca tccctgtgct gaacgaactt      420

gggattcgcc tgcccccatt gcacacgcag gtcgcatcgc tctccggtgg tcaacgccag      480

acggtcgctg tggcgcgatc cgtcctgtgg ggttcgaaac tcgtcatgct cgatgagccg      540

accgctgcgc tcggcgtcgt gcagcagcgc gcggtgcttg agctcatcca gaggcttgca      600

gcgagcggcc gcgcggtgct cgtcatctcg cacaacatga gcgacgtgtt taaaattgcc      660

aaccgcatcg tggtgctgcg gttggggcga accgtggcga cgttcgatcg ggagcaagtc      720

acgcccgagc aggttgtggc ggccatcacg ggcgcatcgg cgcaagagga ggtcacgtcc      780

taa                                                                    783


<210>   748
<211>   783
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 733

<400>   748
gtggcaacgg aggtcaagac acagccggtc ctcgaggtgc gcagccttcg caagcgattt       60

ggcgccgttc aggcgttgga cggtgtttcg ttttccgtgc atgcaggcga aatcgtggcg      120

ctcgtcgggg acaacggcgc cggtaagtcg accaccatca agatgatcgc gggtgtcgag      180

cagccggacg aaggagagat cttgttcgag ggccagccgg tccgcctgac gagtccagcc      240

gtggcagaaa agtacggcat tcagacggtc taccaggacc tcgcgctctg tgacaacctg      300

gacatcgtct cgaacctgtt tctcggccgg gagctgcggc gcagcgtgat tcccgggctg      360

gtgcgcgtga tcgaccggaa cgagatggag cggcgcgcca tccctgtgct gaacgaactt      420

gggattcgcc tgcccccatt gcacacgcag gtcgcatcgc tctccggtgg tcaacgccag      480

acggtcgctg tggcgcgatc cgtcctgtgg ggttcgaaac tcgtcatgct cgatgagccg      540

accgctgcgc tcggcgtcgt gcagcagcgc gcggtgcttg agctcttaca gaggcttgca      600

gcgagcggcc gcgcggtgct cgtcatctcg cacaacatga gcgacgtgtt taaaattgcc      660

aaccgcatcg tggtgctgcg gttggggcga accgtggcga cgttcgatcg ggagcaagtc      720

acgcccgagc aggttgtggc ggccatcacg ggcgcatcgg cgcaagagga ggtcacgtcc      780

taa                                                                    783


<210>   749
<211>   401
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   749
Met Thr Val Asn Ile Gly Gln Ala Lys Gln Thr Gln Thr Pro Ala Ala 
                5                   10                  15      

Arg Ser Thr Ser Val Phe Asp Arg Ile Ile Gly Gly Glu Phe Gln Gln 
            20                  25                  30          

Leu Pro Val Phe Leu Ser Leu Val Leu Ile Trp Ile Val Phe Glu Ile 
        35                  40                  45              

Leu Asn Asn Ser Phe Leu Thr Ser Arg Asn Leu Ser Asn Leu Val Leu 
    50                  55                  60                  

Gln Met Ala Glu Tyr Gly Leu Leu Gly Val Gly Glu Thr Leu Ile Leu 
65                  70                  75                  80  

Leu Leu Gly Glu Ile Asp Leu Ser Ile Ala Ala Val Ser Ala Ile Gly 
                85                  90                  95      

Gly Ala Ile Leu Ala Val Leu Ala Gly Asn Gly Val Asn Pro Tyr Val 
            100                 105                 110         

Ala Ile Leu Ala Gly Ala Leu Ser Gly Thr Val Leu Gly Leu Phe Gln 
        115                 120                 125             

Gly Phe Trp Val Thr Val Leu Arg Val Pro Ser Phe Ile Val Thr Leu 
    130                 135                 140                 

Ala Gly Ser Leu Ala Phe Leu Gly Leu Leu Phe Val Leu Ile Gly Gln 
145                 150                 155                 160 

Glu Gly Thr Val Pro Ile Met Asn Asn Thr Ile Asn Ala Ile Ala Gly 
                165                 170                 175     

Asn Tyr Leu Pro Asp Trp Leu Ser Trp Val Leu Val Ala Val Ala Leu 
            180                 185                 190         

Leu Leu Met Val Trp Thr Ala Val Arg Asp Arg Ala Lys Arg Gln Lys 
        195                 200                 205             

Leu Gly Leu Pro Pro Lys Ser Ala Val Ser Thr Trp Thr Lys Leu Ile 
    210                 215                 220                 

Leu Ser Ala Ala Val Met Ile Gly Ala Thr Val Leu Leu Asn Ala Tyr 
225                 230                 235                 240 

Gln Gly Val Pro Ile Ala Gly Leu Val Leu Ile Val Phe Val Val Leu 
                245                 250                 255     

Leu Ala Trp Ile Cys Gln Ser Thr Ala Phe Gly Arg His Ile Tyr Ala 
            260                 265                 270         

Val Gly Gly Asn Ala Glu Ala Ala Arg Arg Ala Gly Ile Asn Val Lys 
        275                 280                 285             

Gly Val Arg Ile Met Val Phe Thr Leu Ala Gly Thr Met Ala Ala Ile 
    290                 295                 300                 

Gly Gly Ile Val Gly Ala Ser Arg Leu Gly Ala Ala Ser Thr Ala Ser 
305                 310                 315                 320 

Gly Gly Ser Asp Leu Leu Met Asp Ser Ile Ala Ala Ala Val Ile Gly 
                325                 330                 335     

Gly Thr Ser Leu Phe Gly Gly Tyr Gly Ser Val Trp Asn Ala Leu Leu 
            340                 345                 350         

Gly Ala Leu Val Ile Gly Ser Ile Glu Asn Gly Met Ala Leu Leu Asn 
        355                 360                 365             

Ala Pro Thr Ser Thr Lys Tyr Leu Val Glu Gly Ala Ile Leu Leu Leu 
    370                 375                 380                 

Ala Val Thr Phe Asp Thr Phe Thr Arg Met Arg Arg Lys Gln Leu Gly 
385                 390                 395                 400 

Arg 
    

<210>   750
<211>   1206
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   750
atgacagtca acatcggtca ggccaagcag acgcagacgc ccgcggcgcg cagcacctcg       60

gtgttcgatc gcatcattgg cggggagttt caacagctgc cggtgttttt gtcgctggtc      120

ctcatctgga ttgtgtttga gatcttgaac aacagctttc tcacgagccg caacctgtcg      180

aacctcgtgc tgcagatggc ggaatacggc ctcctcgggg tcggcgagac gctcattctc      240

ctgctcgggg agattgactt gtccatcgcg gccgtgagcg ccatcggcgg cgcgattctc      300

gcggtgttgg cgggcaatgg tgtaaatccg tatgtggcga ttctcgccgg cgccttgagc      360

ggcacggtgc tcgggttgtt ccaaggcttt tgggtgacgg tgcttcgcgt gccgtcgttt      420

atcgtgacgc tggccggatc gctcgctttt ttgggtctgt tgtttgtcct catcggccag      480

gagggcacgg tgcccatcat gaacaacacc atcaatgcca tcgcgggtaa ctacctgccc      540

gattggctga gttgggtgtt ggtggccgtg gctttgctcc tcatggtgtg gacagcggtg      600

cgcgatcgcg ccaagcggca gaagcttggg ctgcccccga aatctgcggt gtcgacgtgg      660

acgaagctca tcctgagcgc cgcggtgatg attggcgcga cggtgctgct caacgcctat      720

cagggcgtgc ccatcgcggg gctggtgctg attgtgtttg tggtgctgct cgcgtggatc      780

tgtcagagca ccgcgtttgg ccgccacatc tatgcggtgg gcggcaatgc ggaagccgcg      840

cgccgggccg gtatcaacgt gaagggcgtg cggatcatgg tgttcacgct cgcgggcacc      900

atggcggcca tcggcggcat cgtcggcgcg tccaggctgg gtgcggcgtc cacggcgtcc      960

ggcggcagcg atttgctcat ggactcgatt gcggcggccg tgatcggcgg cacgagcctg     1020

ttcggcggct atgggagcgt gtggaacgcg cttctcggcg cgctcgtcat cggcagcatc     1080

gagaacggca tggcgctgtt gaacgcgccg accagcacga agtatctggt ggaaggcgcc     1140

atcttgttgc tcgcggtcac gttcgacacg ttcacccgca tgcggcggaa gcagttgggt     1200

agatga                                                                1206


<210>   751
<211>   390
<212>   PRT
<213>   Herpetosiphon aurantiacus ATCC 23779

<400>   751
Glu Arg Phe Arg Gln Gly Asn Leu Gly Ser Leu Pro Val Ile Ile Gly 
                5                   10                  15      

Leu Ile Ile Ile Ala Leu Val Phe Gln Ser Ile Asn Lys Asn Phe Leu 
            20                  25                  30          

Thr Pro Leu Asn Leu Thr Asn Leu Met Val Gln Ile Ala Ala Met Gly 
        35                  40                  45              

Thr Ile Ser Thr Gly Val Val Leu Ile Leu Leu Leu Gly Glu Val Asp 
    50                  55                  60                  

Leu Ser Ala Gly Gln Val Ser Gly Leu Ala Ala Ala Val Met Ala Val 
65                  70                  75                  80  

Leu Val Ser Arg His Asn Leu Pro Ala Ala Val Ala Ile Ile Gly Ala 
                85                  90                  95      

Ile Val Val Gly Ala Leu Val Gly Leu Leu Gln Gly Trp Trp Ile Ser 
            100                 105                 110         

Thr Phe Arg Val Pro Ser Phe Val Val Thr Leu Ala Gly Leu Leu Ala 
        115                 120                 125             

Trp Gln Gly Ser Arg Leu Arg Val Leu Gly Asp Thr Gly Ser Ile Asn 
    130                 135                 140                 

Ile Thr Asn Lys Phe Ile Asn Asp Ile Ala Asn Tyr Lys Leu Pro Ile 
145                 150                 155                 160 

Trp Leu Gly Trp Val Leu Gly Ile Val Ser Val Val Val Tyr Thr Leu 
                165                 170                 175     

Ile Val Phe Asn Glu Tyr Arg Ser Arg Arg Ala Ala Glu Leu Pro Thr 
            180                 185                 190         

Gly Ser Leu Asn Gly Val Phe Trp Arg Val Gly Val Val Gly Ala Ser 
        195                 200                 205             

Val Leu Ala Gly Val Ala Met Met Ser Val Asn Arg Asn Ala Asn Ala 
    210                 215                 220                 

Ala Gly Asn Pro Ile Gln Gly Val Pro Ser Ala Val Ile Ile Phe Leu 
225                 230                 235                 240 

Thr Phe Leu Ile Ile Phe Asp Phe Ile Thr Gln Arg Thr Arg Phe Gly 
                245                 250                 255     

Arg Tyr Val Tyr Ala Val Gly Gly Asn Thr Glu Ala Ala Arg Arg Ala 
            260                 265                 270         

Gly Ile Asn Val Asn Arg Ile Arg Ile Thr Ile Phe Met Leu Ala Ser 
        275                 280                 285             

Ala Leu Ala Ala Cys Gly Gly Ile Leu Ala Ala Ser Arg Leu Asn Ala 
    290                 295                 300                 

Ala Asn Gln Ser Ser Gly Asp Gly Asp Val Leu Leu Asn Ala Ile Ala 
305                 310                 315                 320 

Ala Ala Val Ile Gly Gly Thr Ser Leu Phe Gly Gly Arg Gly Arg Ile 
                325                 330                 335     

Trp Ser Ala Leu Leu Gly Ala Leu Val Ile Gly Ala Ile Ala Asn Gly 
            340                 345                 350         

Met Asp Leu Leu Ala Leu Lys Ser Ser Ile Lys Phe Ile Val Thr Gly 
        355                 360                 365             

Ser Val Leu Leu Leu Ala Val Thr Ile Asp Ala Ala Ser Arg Ala Arg 
    370                 375                 380                 

Arg Glu Asn Ser Gly Arg 
385                 390 

<210>   752
<211>   378
<212>   PRT
<213>   Stigmatella aurantiaca DW4/3-1

<400>   752
Arg Leu Ser Gln Gly Glu Leu Gly Ser Leu Pro Val Ile Ile Gly Leu 
                5                   10                  15      

Cys Val Ile Trp Leu Ile Phe Tyr Ile Ala Asn Asp Arg Phe Leu Ser 
            20                  25                  30          

Ala Val Asn Leu Thr Asn Leu Met Leu Gln Ile Thr Ala Met Gly Thr 
        35                  40                  45              

Ile Ser Ala Gly Ile Val Leu Val Leu Leu Leu Gly Asp Ile Asp Leu 
    50                  55                  60                  

Ser Ala Gly Ala Val Ser Gly Leu Ser Ala Ala Val Met Ala Leu Asn
65                  70                  75                  80  

Val Lys Met Gly Tyr Gly Ala Val Pro Ser Leu Leu Ala Gly Leu Ala
                85                  90                  95      

Thr Gly Ala Ala Ile Gly Ala Phe His Gly Leu Trp Met Thr Arg 
            100                 105                 110         

Phe Arg Val Pro Pro Phe Val Val Thr Leu Ala Gly Leu Leu Gly Trp 
            115                 120                 125             

Gln Gly Ala Gln Leu Phe Val Leu Gly Asn Thr Gly Thr Val Asn Leu 
        130                 135                 140                 

Asn Asp Ser Phe Ile Ile Gly Leu Ala Gly Thr Phe Phe Glu Pro Ala 
    145                 150                 155                 

Ile Ala Trp Leu Val Val Ala Leu Ile Val Val Val His Val Ala Thr 
160                 165                 170                 175     

Val Phe Val Glu Arg Arg Arg Arg Glu Ala Ala Gly Leu Pro Leu Val 
                180                 185                 190         

Pro Leu Arg Ser Thr Val Val Arg Met Val Phe Thr His Gly Ala Leu 
            195                 200                 205             

Val Ala Ala Val Ala Val Phe Thr Gln Asp Arg Gly Leu Pro Leu Ala 
        210                 215                 220                 

Ala Leu Ile Phe Gly Gly Val Val Leu Leu Leu Glu Leu Leu Ile Arg 
    225                 230                 235                 

His Thr Arg Phe Gly Arg His Thr Phe Ala Val Gly Gly Asn Ala Glu 
240                 245                 250                 255     

Ala Ala Arg Arg Ala Gly Ile Arg Val Asp Arg Ile Arg Val Thr Ile 
                260                 265                 270         

Phe Thr Leu Ala Ser Thr Met Ala Ala Ala Gly Gly Ile Leu Ala Ala 
            275                 280                 285             

Ser Arg Leu Leu Ala Val Asn Gln Ser Ser Gly Ser Gly Asp Val Leu 
        290                 295                 300                 

Leu Asn Ala Ile Ala Ala Ala Val Ile Gly Gly Thr Ser Leu Phe Gly 
    305                 310                 315                 

Gly Arg Gly Ser Ala Trp Ser Ala Leu Leu Gly Ala Leu Val Ile Gly 
320                 325                 330                 335     

Ser Ile Ser Asn Gly Met Asp Leu Leu Ala Leu Ser Ser Ser Val Lys 
                340                 345                 350         

Phe Met Val Thr Gly Ala Val Leu Leu Val Ala Ala Ser Ile Asp Ala 
            355                 360                 365             

Leu Ser Arg Arg Gly Arg Gln Ala Ala Gly Arg 
        370                 375                 

<210>   753
<211>   383
<212>   PRT
<213>   Frankia sp. EAN1pec

<400>   753
Ser Ala Leu Arg His Val Arg Ala Gly Glu Leu Gly Ser Leu Pro Val 
                5                   10                  15      

Ile Val Gly Leu Val Val Ile Trp Thr Ile Phe Gln Phe Gln Asn Ser 
            20                  25                  30          

Asn Phe Leu Thr Ser Tyr Asn Leu Thr Asn Leu Ala Leu Gln Val Ala 
        35                  40                  45              

Ala Thr Gly Thr Ile Ala Thr Gly Val Phe Leu Val Leu Leu Leu Gly 
    50                  55                  60                  

Glu Ile Asp Leu Ser Val Gly Trp Val Ser Gly Leu Cys Ala Ser Val 
65                  70                  75                  80  

Met Ala Val Leu Ser Val Arg His Gly Trp Ala Pro Val Leu Ala Ile 
                85                  90                  95      

Val Ala Ala Leu Val Val Gly Val Ala Val Gly Ala Leu Gln Gly Ser 
            100                 105                 110         

Leu Phe Ala Val Phe Gly Val Pro Ser Phe Val Val Thr Leu Ala Gly 
        115                 120                 125             

Phe Ile Ala Trp Gln Gly Val Gln Leu Lys Val Leu Gly Arg Asp Gly 
    130                 135                 140                 

Ser Leu Asn Leu Pro Asp Ser Glu Ile Thr Lys Leu Thr Ser Thr Phe 
145                 150                 155                 160 

Phe Thr Asp Ala Thr Gly Trp Val Ile Ala Gly Ile Ala Val Ala Gly 
                165                 170                 175     

Tyr Ala Gly Ala Gln Leu Ala Glu Val Arg Gly Arg Arg Arg Ala Gly 
            180                 185                 190         

Leu Arg Pro Arg Pro Ile Ala Glu Val Ala Val Arg Val Val Val Val 
        195                 200                 205             

Gly Gly Ala Leu Ile Ala Ala Val Ala Ile Leu Asn Asp Asp Arg Gly 
    210                 215                 220                 

Leu Pro Leu Ala Leu Leu Ile Phe Gly Cys Leu Val Leu Leu Val Asp 
225                 230                 235                 240 

Leu Val Ser Arg Arg Thr Ser Tyr Gly Arg His Leu Tyr Ala Val Gly 
                245                 250                 255     

Gly Asn Val Glu Ala Ala Arg Arg Ala Gly Ile Asn Val Arg Ala Leu 
            260                 265                 270         

Arg Val Ser Ala Phe Ala Ala Ala Ser Cys Leu Ala Gly Val Gly Gly 
        275                 280                 285             

Val Leu Ala Ala Ala Arg Leu Thr Ser Val Thr Gln Ala Ser Gly Gly 
    290                 295                 300                 

Ser Asp Thr Leu Leu Asn Ala Ile Ala Ala Ala Val Ile Gly Gly Thr 
305                 310                 315                 320 

Ser Leu Phe Gly Gly Arg Gly Arg Ala Trp Ser Ala Leu Leu Gly Ile 
                325                 330                 335     

Leu Val Ile Gly Ser Ile Ala Asn Gly Met Asp Leu Leu Gly Leu Asp 
            340                 345                 350         

Gln Ser Val Lys Phe Ile Ile Thr Gly Ser Val Leu Leu Ala Ala Val 
        355                 360                 365             

Leu Leu Asp Ala Ala Ala Arg Arg Gly Arg Gln Ala Ser Gly Arg 
    370                 375                 380             

<210>   754
<211>   369
<212>   PRT
<213>   Acidiphilium cryptum JF-5

<400>   754
Leu Pro Val Ile Ala Ala Leu Ile Val Ile Trp Ile Val Phe Glu Thr 
                5                   10                  15      

Leu Asn Ala Asn Phe Leu Thr Pro Arg Asn Leu Ser Asn Leu Ala Ala 
            20                  25                  30          

Gln Ile Val Val Thr Gly Thr Leu Ala Leu Ala Glu Ile Tyr Ile Ile 
        35                  40                  45              

Leu Leu Gly Met Ile Asp Leu Ser Ile Gly Trp Asn Ser Val Leu Ala 
    50                  55                  60                  

Ala Ser Val Phe Ser Leu Ala Thr Val Phe Phe His Leu Pro Val Gly 
65                  70                  75                  80  

Val Gly Ile Val Leu Gly Ile Ala Leu Ala Thr Gly Leu Gly Phe Leu 
                85                  90                  95      

Gln Gly Met Val Val Ser Arg Ile Gly Val Pro Ser Phe Val Val Thr 
            100                 105                 110         

Leu Gly Gly Gly Met Ile Ala Glu Gly Leu Thr Leu Ala Ile Leu Thr 
        115                 120                 125             

Pro His Gly Gly Ser Val Pro Leu Ala Asp Asn Phe Thr Thr Ala Ile 
    130                 135                 140                 

Gly Thr Leu Asn Leu Asp Pro Leu Trp Ser Trp Val Leu Ser Leu Leu 
145                 150                 155                 160 

Leu Phe Gly Ala Tyr Ala Ala Val Thr Leu Asn Gly Ile Arg Lys Arg 
                165                 170                 175     

Thr Ala Ser Gly His Glu Gly Gly Phe Ala Ala Thr Met Arg Leu Val 
            180                 185                 190         

Gly Val Ala Ile Met Leu Phe Gly Ala Val Phe Met Leu Asn Ala Tyr 
        195                 200                 205             

Arg Gly Val Pro Phe Leu Leu Met Ile Phe Leu Ile Ala Leu Phe Ala 
    210                 215                 220                 

Ser Ala Phe Val Thr Lys Ser Thr Arg Phe Gly Arg His Leu Tyr Ala 
225                 230                 235                 240 

Val Gly Gly Asn Ala Glu Ala Ala Arg Arg Ala Gly Ile Ser Val Lys 
                245                 250                 255     

Gly Ile Gln Leu Ala Val Phe Ile Ile Ala Gly Phe Leu Val Gly Leu 
            260                 265                 270         

Ala Gly Tyr Leu Asp Ala Ala Arg Leu Gly Val Ala Ser Ala Ser Val 
        275                 280                 285             

Gly Asn Gly Asp Ile Met Leu Asn Ala Val Ala Ala Ala Val Ile Gly 
    290                 295                 300                 

Gly Thr Ser Leu Phe Gly Gly Arg Gly Ser Val Tyr Gly Ala Leu Phe 
305                 310                 315                 320 

Gly Ala Leu Val Ile Ala Ser Val Ser Asn Gly Met Asn Leu Leu Gly 
                325                 330                 335     

Ala Ala Ser Ser Val Arg Phe Ile Val Glu Gly Leu Ile Leu Leu Ala 
            340                 345                 350         

Ala Ile Thr Ile Asp Thr Ile Leu Arg Leu Arg Arg Met Arg Ser Gly 
        355                 360                 365             

Arg 
    

<210>   755
<211>   380
<212>   PRT
<213>   Thermobifida fusca YX

<400>   755
Arg Leu Arg Ser Gly Glu Leu Gly Pro Leu Pro Val Leu Val Gly Leu 
                5                   10                  15      

Ile Val Ile Ala Gly Val Phe Trp Ser Leu Asn Pro Lys Phe Leu Thr 
            20                  25                  30          

Ala Gln Asn Leu Ser Asn Leu Thr Leu Gln Ile Val Ala Val Gly Phe 
        35                  40                  45              

Met Ala Cys Gly Val Ile Met Val Leu Leu Leu Gly Glu Ile Asp Leu 
    50                  55                  60                  

Ser Val Gly Ser Val Ala Gly Val Cys Gly Val Ile Val Thr Leu Leu 
65                  70                  75                  80  

Ala Val Asn Tyr Gln Trp Asn Glu Ile Ala Ala Ile Val Val Ala Ile 
                85                  90                  95      

Leu Ala Gly Thr Leu Ile Gly Thr Leu His Gly Thr Ile Phe Ala Lys 
            100                 105                 110         

Ile Gly Val Pro Ala Phe Val Val Thr Leu Ala Gly Leu Ile Gly Trp 
        115                 120                 125             

Gln Gly Ala Gln Leu Tyr Leu Leu Gly Pro Glu Gly Thr Ile Asn Val 
    130                 135                 140                 

Pro Tyr Asn Gly Leu Ile Gly Ala Ile Thr His Thr Tyr Leu Val Pro 
145                 150                 155                 160 

Ala Val Gly Trp Gly Ile Gly Ile Thr Ala Val Ala Leu Tyr Gly Leu 
                165                 170                 175     

Ile Ser Val Arg Gly Ala Arg Arg Arg Ala Ala Ala Gly Leu Pro Ala 
            180                 185                 190         

Lys Ser Val Thr Glu Ile Gly Val Arg Thr Ala Leu Leu Ala Leu Pro 
        195                 200                 205             

Val Leu Gly Gly Val Trp Val Leu Asn Ser Phe Arg Gly Val Pro Val 
    210                 215                 220                 

Ala Phe Leu Leu Phe Val Gly Val Val Val Leu Phe Asp Leu Ile Leu 
225                 230                 235                 240 

Arg Lys Thr Arg Tyr Gly Arg Met Val Phe Ala Val Gly Gly Ser Ala 
                245                 250                 255     

Glu Ala Ala Arg Arg Ala Gly Ile Asn Val Asp Leu Ile Arg Ile Ser 
            260                 265                 270         

Val Phe Ala Leu Ala Ser Thr Leu Ala Gly Val Gly Gly Ile Leu Leu 
        275                 280                 285             

Val Ser Arg Ser Tyr Ala Val Asn Gln Leu Thr Gly Gly Gly Asp Asp 
    290                 295                 300                 

Leu Met Met Ala Ile Ala Ala Ala Val Ile Gly Gly Thr Ser Leu Phe 
305                 310                 315                 320 

Gly Gly Arg Gly Ser Ala Tyr Ser Ala Leu Leu Gly Gly Leu Val Leu 
                325                 330                 335     

Gly Ala Ile Ser Ser Gly Leu Tyr Leu Leu Gln Met Asp Ser Ser Val 
            340                 345                 350         

Arg Phe Met Ile Thr Ala Val Val Leu Leu Val Ala Val Ile Leu Asp 
        355                 360                 365             

Ala Val Ser Arg Arg Thr Arg Lys Ala His Ala Arg 
    370                 375                 380 

<210>   756
<211>   401
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   756
Met Thr Val Asn Ile Gly Gln Ala Lys Gln Thr Gln Thr Pro Ala Ala 
                5                   10                  15      

Arg Ser Thr Ser Val Phe Asp Arg Ile Ile Gly Gly Glu Phe Gln Gln 
            20                  25                  30          

Leu Pro Val Phe Leu Ser Leu Val Leu Ile Trp Ile Val Phe Glu Ile 
        35                  40                  45              

Leu Asn Asn Ser Phe Leu Thr Ser Arg Asn Leu Ser Asn Leu Val Leu 
    50                  55                  60                  

Gln Met Ala Glu Tyr Gly Leu Leu Gly Val Gly Glu Thr Leu Ile Leu 
65                  70                  75                  80  

Leu Leu Gly Glu Ile Asp Leu Ser Ile Ala Ala Val Ser Ala Ile Gly 
                85                  90                  95      

Gly Ala Ile Leu Ala Val Leu Ala Gly Asn Gly Val Asn Pro Tyr Val 
            100                 105                 110         

Ala Ile Leu Ala Gly Ala Leu Ser Gly Thr Val Leu Gly Leu Phe Gln 
        115                 120                 125             

Gly Phe Trp Val Thr Val Leu Arg Val Pro Ser Phe Ile Val Thr Leu 
    130                 135                 140                 

Ala Gly Ser Leu Ala Phe Leu Gly Leu Leu Phe Val Leu Ile Gly Gln 
145                 150                 155                 160 

Glu Gly Thr Val Pro Ile Met Asn Asn Thr Ile Asn Ala Ile Ala Gly 
                165                 170                 175     

Asn Tyr Leu Pro Asp Trp Leu Ser Trp Val Leu Val Ala Val Ala Leu 
            180                 185                 190         

Leu Leu Met Val Trp Thr Ala Val Lys Asp Arg Ala Lys Arg Gln Lys 
        195                 200                 205             

Leu Gly Leu Pro Pro Lys Ser Ala Val Ser Thr Trp Thr Lys Leu Ile 
    210                 215                 220                 

Leu Ser Ala Ala Val Met Ile Gly Ala Thr Val Leu Leu Asn Ala Tyr 
225                 230                 235                 240 

Gln Gly Val Pro Ile Ala Gly Leu Val Leu Ile Val Phe Val Val Leu 
                245                 250                 255     

Leu Ala Trp Ile Cys Gln Ser Thr Ala Phe Gly Arg His Ile Tyr Ala 
            260                 265                 270         

Val Gly Gly Asn Ala Glu Ala Ala Arg Arg Ala Gly Ile Asn Val Lys 
        275                 280                 285             

Gly Val Arg Ile Met Val Phe Thr Leu Ala Gly Thr Met Ala Ala Ile 
    290                 295                 300                 

Gly Gly Ile Val Gly Ala Ser Arg Leu Gly Ala Ala Ser Thr Ala Ser 
305                 310                 315                 320 

Gly Gly Ser Asp Leu Leu Met Asp Ser Ile Ala Ala Ala Val Ile Gly 
                325                 330                 335     

Gly Thr Ser Leu Phe Gly Gly Tyr Gly Ser Val Trp Asn Ala Leu Leu 
            340                 345                 350         

Gly Ala Leu Val Ile Gly Ser Ile Glu Asn Gly Met Ala Leu Leu Asn 
        355                 360                 365             

Ala Pro Thr Ser Thr Lys Tyr Leu Val Glu Gly Ala Ile Leu Leu Leu 
    370                 375                 380                 

Ala Val Thr Phe Asp Thr Phe Thr Arg Met Arg Arg Lys Gln Leu Gly 
385                 390                 395                 400 

Arg 
    

<210>   757
<211>   401
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   757
Met Thr Val Asn Ile Gly Gln Ala Lys Gln Thr Gln Thr Pro Ala Ala 
                5                   10                  15      

Arg Ser Thr Ser Val Phe Asp Arg Ile Ile Gly Gly Glu Phe Gln Gln 
            20                  25                  30          

Leu Pro Val Phe Leu Ser Leu Val Leu Ile Trp Ile Val Phe Glu Ile 
        35                  40                  45              

Leu Asn Asn Ser Phe Leu Thr Ser Arg Asn Leu Ser Asn Leu Val Leu 
    50                  55                  60                  

Gln Met Ala Glu Tyr Gly Leu Leu Gly Val Gly Glu Thr Leu Ile Leu 
65                  70                  75                  80  

Leu Leu Gly Glu Ile Asp Leu Ser Ile Ala Ala Ile Ser Ala Ile Gly 
                85                  90                  95      

Gly Ala Ile Leu Ala Val Leu Ala Gly Asn Gly Val Asn Pro Tyr Val 
            100                 105                 110         

Ala Ile Leu Ala Gly Ala Leu Ser Gly Thr Val Leu Gly Leu Phe Gln 
        115                 120                 125             

Gly Phe Trp Val Thr Val Leu Arg Val Pro Ser Phe Ile Val Thr Leu 
    130                 135                 140                 

Ala Gly Ser Leu Ala Phe Leu Gly Leu Leu Phe Val Leu Ile Gly Gln 
145                 150                 155                 160 

Glu Gly Thr Val Pro Ile Met Asn Asn Thr Ile Asn Ala Ile Ala Gly 
                165                 170                 175     

Asn Tyr Leu Pro Asp Trp Leu Ser Trp Val Leu Val Ala Val Ala Leu 
            180                 185                 190         

Leu Leu Met Val Trp Thr Ala Val Arg Asp Arg Ala Lys Arg Gln Lys 
        195                 200                 205             

Leu Gly Leu Pro Pro Lys Ser Ala Val Ser Thr Trp Thr Lys Leu Ile 
    210                 215                 220                 

Leu Ser Ala Ala Val Met Ile Gly Ala Thr Val Leu Leu Asn Ala Tyr 
225                 230                 235                 240 

Gln Gly Val Pro Ile Ala Gly Leu Val Leu Ile Val Phe Val Val Leu 
                245                 250                 255     

Leu Ala Trp Ile Cys Gln Ser Thr Ala Phe Gly Arg His Ile Tyr Ala 
            260                 265                 270         

Val Gly Gly Asn Ala Glu Ala Ala Arg Arg Ala Gly Ile Asn Val Lys 
        275                 280                 285             

Gly Val Arg Ile Met Val Phe Thr Leu Ala Gly Thr Met Ala Ala Ile 
    290                 295                 300                 

Gly Gly Ile Val Gly Ala Ser Arg Leu Gly Ala Ala Ser Thr Ala Ser 
305                 310                 315                 320 

Gly Gly Ser Asp Leu Leu Met Asp Ser Ile Ala Ala Ala Val Ile Gly 
                325                 330                 335     

Gly Thr Ser Leu Phe Gly Gly Tyr Gly Ser Val Trp Asn Ala Leu Leu 
            340                 345                 350         

Gly Ala Leu Val Ile Gly Ser Ile Glu Asn Gly Met Ala Leu Leu Asn 
        355                 360                 365             

Ala Pro Thr Ser Thr Lys Tyr Leu Val Glu Gly Ala Ile Leu Leu Leu 
    370                 375                 380                 

Ala Val Thr Phe Asp Thr Phe Thr Arg Met Arg Arg Lys Gln Leu Gly 
385                 390                 395                 400 

Arg 
    

<210>   758
<211>   401
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   758
Met Thr Val Asn Ile Gly Gln Ala Lys Gln Thr Gln Thr Pro Ala Ala 
                5                   10                  15      

Arg Ser Thr Ser Val Phe Asp Arg Ile Ile Gly Gly Glu Phe Gln Gln 
            20                  25                  30          

Leu Pro Val Phe Leu Ser Leu Val Leu Ile Trp Ile Val Phe Glu Ile 
        35                  40                  45              

Leu Asn Asn Ser Phe Leu Thr Ser Arg Asn Leu Ser Asn Leu Val Leu 
    50                  55                  60                  

Gln Met Ala Glu Tyr Gly Leu Leu Gly Val Gly Glu Thr Ile Ile Leu 
65                  70                  75                  80  

Leu Leu Gly Glu Ile Asp Leu Ser Ile Ala Ala Val Ser Ala Ile Gly 
                85                  90                  95      

Gly Ala Ile Leu Ala Val Leu Ala Gly Asn Gly Val Asn Pro Tyr Val 
            100                 105                 110         

Ala Ile Leu Ala Gly Ala Leu Ser Gly Thr Val Leu Gly Leu Phe Gln 
        115                 120                 125             

Gly Phe Trp Val Thr Val Leu Arg Val Pro Ser Phe Ile Val Thr Leu 
    130                 135                 140                 

Ala Gly Ser Leu Ala Phe Leu Gly Leu Leu Phe Val Leu Ile Gly Gln 
145                 150                 155                 160 

Glu Gly Thr Val Pro Ile Met Asn Asn Thr Ile Asn Ala Ile Ala Gly 
                165                 170                 175     

Asn Tyr Leu Pro Asp Trp Leu Ser Trp Val Leu Val Ala Val Ala Leu 
            180                 185                 190         

Leu Leu Met Val Trp Thr Ala Val Arg Asp Arg Ala Lys Arg Gln Lys 
        195                 200                 205             

Leu Gly Leu Pro Pro Lys Ser Ala Val Ser Thr Trp Thr Lys Leu Ile 
    210                 215                 220                 

Leu Ser Ala Ala Val Met Ile Gly Ala Thr Val Leu Leu Asn Ala Tyr 
225                 230                 235                 240 

Gln Gly Val Pro Ile Ala Gly Leu Val Leu Ile Val Phe Val Val Leu 
                245                 250                 255     

Leu Ala Trp Ile Cys Gln Ser Thr Ala Phe Gly Arg His Ile Tyr Ala 
            260                 265                 270         

Val Gly Gly Asn Ala Glu Ala Ala Arg Arg Ala Gly Ile Asn Val Lys 
        275                 280                 285             

Gly Val Arg Ile Met Val Phe Thr Leu Ala Gly Thr Met Ala Ala Ile 
    290                 295                 300                 

Gly Gly Ile Val Gly Ala Ser Arg Leu Gly Ala Ala Ser Thr Ala Ser 
305                 310                 315                 320 

Gly Gly Ser Asp Leu Leu Met Asp Ser Ile Ala Ala Ala Val Ile Gly 
                325                 330                 335     

Gly Thr Ser Leu Phe Gly Gly Tyr Gly Ser Val Trp Asn Ala Leu Leu 
            340                 345                 350         

Gly Ala Leu Val Ile Gly Ser Ile Glu Asn Gly Met Ala Leu Leu Asn 
        355                 360                 365             

Ala Pro Thr Ser Thr Lys Tyr Leu Val Glu Gly Ala Ile Leu Leu Leu 
    370                 375                 380                 

Ala Val Thr Phe Asp Thr Phe Thr Arg Met Arg Arg Lys Gln Leu Gly 
385                 390                 395                 400 

Arg 
    

<210>   759
<211>   401
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   759
Met Thr Val Asn Ile Gly Gln Ala Lys Gln Thr Gln Thr Pro Ala Ala 
                5                   10                  15      

Arg Ser Thr Ser Val Phe Asp Arg Ile Ile Gly Gly Glu Phe Gln Gln 
            20                  25                  30          

Leu Pro Val Phe Leu Ser Leu Val Leu Ile Trp Ile Val Phe Glu Ile 
        35                  40                  45              

Leu Asn Asn Ser Phe Leu Thr Ser Lys Asn Leu Ser Asn Leu Val Leu 
    50                  55                  60                  

Gln Met Ala Glu Tyr Gly Leu Leu Gly Val Gly Glu Thr Leu Ile Leu 
65                  70                  75                  80  

Leu Leu Gly Glu Ile Asp Leu Ser Ile Ala Ala Val Ser Ala Ile Gly 
                85                  90                  95      

Gly Ala Ile Leu Ala Val Leu Ala Gly Asn Gly Val Asn Pro Tyr Val 
            100                 105                 110         

Ala Ile Leu Ala Gly Ala Leu Ser Gly Thr Val Leu Gly Leu Phe Gln 
        115                 120                 125             

Gly Phe Trp Val Thr Val Leu Arg Val Pro Ser Phe Ile Val Thr Leu 
    130                 135                 140                 

Ala Gly Ser Leu Ala Phe Leu Gly Leu Leu Phe Val Leu Ile Gly Gln 
145                 150                 155                 160 

Glu Gly Thr Val Pro Ile Met Asn Asn Thr Ile Asn Ala Ile Ala Gly 
                165                 170                 175     

Asn Tyr Leu Pro Asp Trp Leu Ser Trp Val Leu Val Ala Val Ala Leu 
            180                 185                 190         

Leu Leu Met Val Trp Thr Ala Val Arg Asp Arg Ala Lys Arg Gln Lys 
        195                 200                 205             

Leu Gly Leu Pro Pro Lys Ser Ala Val Ser Thr Trp Thr Lys Leu Ile 
    210                 215                 220                 

Leu Ser Ala Ala Val Met Ile Gly Ala Thr Val Leu Leu Asn Ala Tyr 
225                 230                 235                 240 

Gln Gly Val Pro Ile Ala Gly Leu Val Leu Ile Val Phe Val Val Leu 
                245                 250                 255     

Leu Ala Trp Ile Cys Gln Ser Thr Ala Phe Gly Arg His Ile Tyr Ala 
            260                 265                 270         

Val Gly Gly Asn Ala Glu Ala Ala Arg Arg Ala Gly Ile Asn Val Lys 
        275                 280                 285             

Gly Val Arg Ile Met Val Phe Thr Leu Ala Gly Thr Met Ala Ala Ile 
    290                 295                 300                 

Gly Gly Ile Val Gly Ala Ser Arg Leu Gly Ala Ala Ser Thr Ala Ser 
305                 310                 315                 320 

Gly Gly Ser Asp Leu Leu Met Asp Ser Ile Ala Ala Ala Val Ile Gly 
                325                 330                 335     

Gly Thr Ser Leu Phe Gly Gly Tyr Gly Ser Val Trp Asn Ala Leu Leu 
            340                 345                 350         

Gly Ala Leu Val Ile Gly Ser Ile Glu Asn Gly Met Ala Leu Leu Asn 
        355                 360                 365             

Ala Pro Thr Ser Thr Lys Tyr Leu Val Glu Gly Ala Ile Leu Leu Leu 
    370                 375                 380                 

Ala Val Thr Phe Asp Thr Phe Thr Arg Met Arg Arg Lys Gln Leu Gly 
385                 390                 395                 400 

Arg 
    

<210>   760
<211>   401
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 749

<400>   760
Met Thr Val Asn Ile Gly Gln Ala Lys Gln Thr Gln Thr Pro Ala Ala 
                5                   10                  15      

Arg Ser Thr Ser Val Phe Asp Arg Ile Ile Gly Gly Glu Phe Gln Gln 
            20                  25                  30          

Leu Pro Val Phe Leu Ser Leu Val Leu Ile Trp Ile Val Phe Glu Ile 
        35                  40                  45              

Leu Asn Asn Ser Phe Leu Thr Ser Arg Asn Leu Ser Asn Leu Val Leu 
    50                  55                  60                  

Gln Met Ala Glu Tyr Gly Leu Leu Gly Val Gly Glu Thr Leu Ile Leu 
65                  70                  75                  80  

Leu Leu Gly Glu Ile Asp Leu Ser Ile Ala Ala Val Ser Ala Ile Gly 
                85                  90                  95      

Gly Ala Ile Leu Ala Val Leu Ala Gly Asn Gly Val Asn Pro Tyr Val 
            100                 105                 110         

Ala Ile Leu Ala Gly Ala Leu Ser Gly Thr Val Leu Gly Leu Phe Gln 
        115                 120                 125             

Gly Phe Trp Val Thr Val Leu Arg Val Pro Ser Phe Ile Val Thr Leu 
    130                 135                 140                 

Ala Gly Ser Leu Ala Phe Leu Gly Leu Leu Phe Val Leu Ile Gly Gln 
145                 150                 155                 160 

Glu Gly Thr Val Pro Ile Met Asn Asn Thr Ile Asn Ala Ile Ala Gly 
                165                 170                 175     

Asn Tyr Leu Pro Asp Trp Leu Ser Trp Val Leu Val Ala Val Ala Leu 
            180                 185                 190         

Leu Leu Met Val Trp Thr Ala Val Arg Asp Arg Ala Lys Arg Gln Lys 
        195                 200                 205             

Leu Gly Leu Pro Pro Lys Ser Ala Val Ser Thr Trp Thr Lys Leu Ile 
    210                 215                 220                 

Leu Ser Ala Ala Val Met Leu Gly Ala Thr Val Leu Leu Asn Ala Tyr 
225                 230                 235                 240 

Gln Gly Val Pro Ile Ala Gly Leu Val Leu Ile Val Phe Val Val Leu 
                245                 250                 255     

Leu Ala Trp Ile Cys Gln Ser Thr Ala Phe Gly Arg His Ile Tyr Ala 
            260                 265                 270         

Val Gly Gly Asn Ala Glu Ala Ala Arg Arg Ala Gly Ile Asn Val Lys 
        275                 280                 285             

Gly Val Arg Ile Met Val Phe Thr Leu Ala Gly Thr Met Ala Ala Ile 
    290                 295                 300                 

Gly Gly Ile Val Gly Ala Ser Arg Leu Gly Ala Ala Ser Thr Ala Ser 
305                 310                 315                 320 

Gly Gly Ser Asp Leu Leu Met Asp Ser Ile Ala Ala Ala Val Ile Gly 
                325                 330                 335     

Gly Thr Ser Leu Phe Gly Gly Tyr Gly Ser Val Trp Asn Ala Leu Leu 
            340                 345                 350         

Gly Ala Leu Val Ile Gly Ser Ile Glu Asn Gly Met Ala Leu Leu Asn 
        355                 360                 365             

Ala Pro Thr Ser Thr Lys Tyr Leu Val Glu Gly Ala Ile Leu Leu Leu 
    370                 375                 380                 

Ala Val Thr Phe Asp Thr Phe Thr Arg Met Arg Arg Lys Gln Leu Gly 
385                 390                 395                 400 

Arg 
    

<210>   761
<211>   1206
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   761
atgacagtca acatcggtca ggccaagcag acgcagacgc ccgcggcgcg cagcacctcg       60

gtgttcgatc gcatcattgg cggggagttt caacagctgc cggtgttttt gtcgctggtc      120

ctcatctgga ttgtgtttga gatcttgaac aacagctttc tcacgagccg caacctgtcg      180

aacctcgtgc tgcagatggc ggaatacggc ctcctcgggg tcggcgagac gctcattctc      240

ctgctcgggg agattgactt gtccatcgcg gccgtgagcg ccatcggcgg cgcgattctc      300

gcggtgttgg cgggcaatgg tgtaaatccg tatgtggcga ttctcgccgg cgccttgagc      360

ggcacggtgc tcgggttgtt ccaaggcttt tgggtgacgg tgcttcgcgt gccgtcgttt      420

atcgtgacgc tggccggatc gctcgctttt ttgggtctgt tgtttgtcct catcggccag      480

gagggcacgg tgcccatcat gaacaacacc atcaatgcca tcgcgggtaa ctacctgccc      540

gattggctga gttgggtgtt ggtggccgtg gctttgctcc tcatggtgtg gacagcggtg      600

aaagatcgcg ccaagcggca gaagcttggg ctgcccccga aatctgcggt gtcgacgtgg      660

acgaagctca tcctgagcgc cgcggtgatg attggcgcga cggtgctgct caacgcctat      720

cagggcgtgc ccatcgcggg gctggtgctg attgtgtttg tggtgctgct cgcgtggatc      780

tgtcagagca ccgcgtttgg ccgccacatc tatgcggtgg gcggcaatgc ggaagccgcg      840

cgccgggccg gtatcaacgt gaagggcgtg cggatcatgg tgttcacgct cgcgggcacc      900

atggcggcca tcggcggcat cgtcggcgcg tccaggctgg gtgcggcgtc cacggcgtcc      960

ggcggcagcg atttgctcat ggactcgatt gcggcggccg tgatcggcgg cacgagcctg     1020

ttcggcggct atgggagcgt gtggaacgcg cttctcggcg cgctcgtcat cggcagcatc     1080

gagaacggca tggcgctgtt gaacgcgccg accagcacga agtatctggt ggaaggcgcc     1140

atcttgttgc tcgcggtcac gttcgacacg ttcacccgca tgcggcggaa gcagttgggt     1200

agatga                                                                1206


<210>   762
<211>   1206
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   762
atgacagtca acatcggtca ggccaagcag acgcagacgc ccgcggcgcg cagcacctcg       60

gtgttcgatc gcatcattgg cggggagttt caacagctgc cggtgttttt gtcgctggtc      120

ctcatctgga ttgtgtttga gatcttgaac aacagctttc tcacgagccg caacctgtcg      180

aacctcgtgc tgcagatggc ggaatacggc ctcctcgggg tcggcgagac gctcattctc      240

ctgctcgggg agattgactt gtccatcgcg gccattagcg ccatcggcgg cgcgattctc      300

gcggtgttgg cgggcaatgg tgtaaatccg tatgtggcga ttctcgccgg cgccttgagc      360

ggcacggtgc tcgggttgtt ccaaggcttt tgggtgacgg tgcttcgcgt gccgtcgttt      420

atcgtgacgc tggccggatc gctcgctttt ttgggtctgt tgtttgtcct catcggccag      480

gagggcacgg tgcccatcat gaacaacacc atcaatgcca tcgcgggtaa ctacctgccc      540

gattggctga gttgggtgtt ggtggccgtg gctttgctcc tcatggtgtg gacagcggtg      600

cgcgatcgcg ccaagcggca gaagcttggg ctgcccccga aatctgcggt gtcgacgtgg      660

acgaagctca tcctgagcgc cgcggtgatg attggcgcga cggtgctgct caacgcctat      720

cagggcgtgc ccatcgcggg gctggtgctg attgtgtttg tggtgctgct cgcgtggatc      780

tgtcagagca ccgcgtttgg ccgccacatc tatgcggtgg gcggcaatgc ggaagccgcg      840

cgccgggccg gtatcaacgt gaagggcgtg cggatcatgg tgttcacgct cgcgggcacc      900

atggcggcca tcggcggcat cgtcggcgcg tccaggctgg gtgcggcgtc cacggcgtcc      960

ggcggcagcg atttgctcat ggactcgatt gcggcggccg tgatcggcgg cacgagcctg     1020

ttcggcggct atgggagcgt gtggaacgcg cttctcggcg cgctcgtcat cggcagcatc     1080

gagaacggca tggcgctgtt gaacgcgccg accagcacga agtatctggt ggaaggcgcc     1140

atcttgttgc tcgcggtcac gttcgacacg ttcacccgca tgcggcggaa gcagttgggt     1200

agatga                                                                1206


<210>   763
<211>   1206
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   763
atgacagtca acatcggtca ggccaagcag acgcagacgc ccgcggcgcg cagcacctcg       60

gtgttcgatc gcatcattgg cggggagttt caacagctgc cggtgttttt gtcgctggtc      120

ctcatctgga ttgtgtttga gatcttgaac aacagctttc tcacgagccg caacctgtcg      180

aacctcgtgc tgcagatggc ggaatacggc ctcctcgggg tcggcgagac gattattctc      240

ctgctcgggg agattgactt gtccatcgcg gccgtgagcg ccatcggcgg cgcgattctc      300

gcggtgttgg cgggcaatgg tgtaaatccg tatgtggcga ttctcgccgg cgccttgagc      360

ggcacggtgc tcgggttgtt ccaaggcttt tgggtgacgg tgcttcgcgt gccgtcgttt      420

atcgtgacgc tggccggatc gctcgctttt ttgggtctgt tgtttgtcct catcggccag      480

gagggcacgg tgcccatcat gaacaacacc atcaatgcca tcgcgggtaa ctacctgccc      540

gattggctga gttgggtgtt ggtggccgtg gctttgctcc tcatggtgtg gacagcggtg      600

cgcgatcgcg ccaagcggca gaagcttggg ctgcccccga aatctgcggt gtcgacgtgg      660

acgaagctca tcctgagcgc cgcggtgatg attggcgcga cggtgctgct caacgcctat      720

cagggcgtgc ccatcgcggg gctggtgctg attgtgtttg tggtgctgct cgcgtggatc      780

tgtcagagca ccgcgtttgg ccgccacatc tatgcggtgg gcggcaatgc ggaagccgcg      840

cgccgggccg gtatcaacgt gaagggcgtg cggatcatgg tgttcacgct cgcgggcacc      900

atggcggcca tcggcggcat cgtcggcgcg tccaggctgg gtgcggcgtc cacggcgtcc      960

ggcggcagcg atttgctcat ggactcgatt gcggcggccg tgatcggcgg cacgagcctg     1020

ttcggcggct atgggagcgt gtggaacgcg cttctcggcg cgctcgtcat cggcagcatc     1080

gagaacggca tggcgctgtt gaacgcgccg accagcacga agtatctggt ggaaggcgcc     1140

atcttgttgc tcgcggtcac gttcgacacg ttcacccgca tgcggcggaa gcagttgggt     1200

agatga                                                                1206


<210>   764
<211>   1206
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   764
atgacagtca acatcggtca ggccaagcag acgcagacgc ccgcggcgcg cagcacctcg       60

gtgttcgatc gcatcattgg cggggagttt caacagctgc cggtgttttt gtcgctggtc      120

ctcatctgga ttgtgtttga gatcttgaac aacagctttc tcacgagcaa aaacctgtcg      180

aacctcgtgc tgcagatggc ggaatacggc ctcctcgggg tcggcgagac gctcattctc      240

ctgctcgggg agattgactt gtccatcgcg gccgtgagcg ccatcggcgg cgcgattctc      300

gcggtgttgg cgggcaatgg tgtaaatccg tatgtggcga ttctcgccgg cgccttgagc      360

ggcacggtgc tcgggttgtt ccaaggcttt tgggtgacgg tgcttcgcgt gccgtcgttt      420

atcgtgacgc tggccggatc gctcgctttt ttgggtctgt tgtttgtcct catcggccag      480

gagggcacgg tgcccatcat gaacaacacc atcaatgcca tcgcgggtaa ctacctgccc      540

gattggctga gttgggtgtt ggtggccgtg gctttgctcc tcatggtgtg gacagcggtg      600

cgcgatcgcg ccaagcggca gaagcttggg ctgcccccga aatctgcggt gtcgacgtgg      660

acgaagctca tcctgagcgc cgcggtgatg attggcgcga cggtgctgct caacgcctat      720

cagggcgtgc ccatcgcggg gctggtgctg attgtgtttg tggtgctgct cgcgtggatc      780

tgtcagagca ccgcgtttgg ccgccacatc tatgcggtgg gcggcaatgc ggaagccgcg      840

cgccgggccg gtatcaacgt gaagggcgtg cggatcatgg tgttcacgct cgcgggcacc      900

atggcggcca tcggcggcat cgtcggcgcg tccaggctgg gtgcggcgtc cacggcgtcc      960

ggcggcagcg atttgctcat ggactcgatt gcggcggccg tgatcggcgg cacgagcctg     1020

ttcggcggct atgggagcgt gtggaacgcg cttctcggcg cgctcgtcat cggcagcatc     1080

gagaacggca tggcgctgtt gaacgcgccg accagcacga agtatctggt ggaaggcgcc     1140

atcttgttgc tcgcggtcac gttcgacacg ttcacccgca tgcggcggaa gcagttgggt     1200

agatga                                                                1206


<210>   765
<211>   1206
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 750

<400>   765
atgacagtca acatcggtca ggccaagcag acgcagacgc ccgcggcgcg cagcacctcg       60

gtgttcgatc gcatcattgg cggggagttt caacagctgc cggtgttttt gtcgctggtc      120

ctcatctgga ttgtgtttga gatcttgaac aacagctttc tcacgagccg caacctgtcg      180

aacctcgtgc tgcagatggc ggaatacggc ctcctcgggg tcggcgagac gctcattctc      240

ctgctcgggg agattgactt gtccatcgcg gccgtgagcg ccatcggcgg cgcgattctc      300

gcggtgttgg cgggcaatgg tgtaaatccg tatgtggcga ttctcgccgg cgccttgagc      360

ggcacggtgc tcgggttgtt ccaaggcttt tgggtgacgg tgcttcgcgt gccgtcgttt      420

atcgtgacgc tggccggatc gctcgctttt ttgggtctgt tgtttgtcct catcggccag      480

gagggcacgg tgcccatcat gaacaacacc atcaatgcca tcgcgggtaa ctacctgccc      540

gattggctga gttgggtgtt ggtggccgtg gctttgctcc tcatggtgtg gacagcggtg      600

cgcgatcgcg ccaagcggca gaagcttggg ctgcccccga aatctgcggt gtcgacgtgg      660

acgaagctca tcctgagcgc cgcggtgatg ttaggcgcga cggtgctgct caacgcctat      720

cagggcgtgc ccatcgcggg gctggtgctg attgtgtttg tggtgctgct cgcgtggatc      780

tgtcagagca ccgcgtttgg ccgccacatc tatgcggtgg gcggcaatgc ggaagccgcg      840

cgccgggccg gtatcaacgt gaagggcgtg cggatcatgg tgttcacgct cgcgggcacc      900

atggcggcca tcggcggcat cgtcggcgcg tccaggctgg gtgcggcgtc cacggcgtcc      960

ggcggcagcg atttgctcat ggactcgatt gcggcggccg tgatcggcgg cacgagcctg     1020

ttcggcggct atgggagcgt gtggaacgcg cttctcggcg cgctcgtcat cggcagcatc     1080

gagaacggca tggcgctgtt gaacgcgccg accagcacga agtatctggt ggaaggcgcc     1140

atcttgttgc tcgcggtcac gttcgacacg ttcacccgca tgcggcggaa gcagttgggt     1200

agatga                                                                1206


<210>   766
<211>   476
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   766
Met Gly Thr Gly Val Pro Val Ser Ser Ala Ala Gly Ile Leu Ala Arg 
                5                   10                  15      

Met Glu Arg Leu Thr Ala Trp Pro Leu Pro Arg Arg Leu Phe Leu Val 
            20                  25                  30          

Ile Gly Leu Gly Tyr Leu Phe Thr Phe Tyr Asp Ile Phe Asp Val Asn 
        35                  40                  45              

Val Ser Phe Val Gln Thr Ala Thr Ser Ile Ile Pro Gly Ala Thr Pro 
    50                  55                  60                  

Ala Asp Ala Ser Arg Tyr Ile Gly Leu Pro Ile Phe Ala Asn Leu Leu 
65                  70                  75                  80  

Gly Tyr Val Val Gly Thr Leu Val Leu Ser Pro Leu Ala Asp Arg Val 
                85                  90                  95      

Gly Arg Arg Arg Met Leu Met Thr Thr Met Phe Ile Thr Gly Val Gly 
            100                 105                 110         

Ser Leu Leu Thr Ala Leu Ala Met Arg Asp Trp Trp Phe Ile Leu Ala 
        115                 120                 125             

Arg Gly Ile Thr Gly Val Gly Val Ala Ala Asp Leu Ala Val Val Asn 
    130                 135                 140                 

Thr Tyr Met Ser Glu Val Ala Pro Arg Arg Ala Arg Ala Lys Tyr Thr 
145                 150                 155                 160 

Ser Gly Leu Phe Ile Phe Ser Gly Val Gly Ala Leu Val Gly Ile Trp 
                165                 170                 175     

Leu Gly Leu Trp Leu Thr Thr Pro Ser Ala Pro Phe Pro Glu Gly Leu 
            180                 185                 190         

Pro Phe Ala Leu Ala Thr Ser Ser Phe His Trp Gly Trp Arg Leu Met 
        195                 200                 205             

Tyr Tyr Ile Gly Ala Val Leu Ala Leu Ile Ala Leu Leu Leu Arg Leu 
    210                 215                 220                 

Glu Leu Pro Glu Ser Pro Arg Trp Leu Ala Ala Lys Gly Arg Val Glu 
225                 230                 235                 240 

Glu Ala Ala Ala Val Val Ala Ala Met Glu Glu Arg Leu Gly Leu Gly 
                245                 250                 255     

Ala Phe Gln Ser Asp Gly Thr Ala Ala Ser Phe Ser Leu Val Ser Asp 
            260                 265                 270         

Thr Arg Ala Pro Tyr Gly Glu Leu Phe Gly Ser Pro Val Tyr Arg Arg 
        275                 280                 285             

Arg Ile Phe Leu Leu Phe Phe Val Trp Leu Phe Ser Tyr Val Thr Val 
    290                 295                 300                 

Tyr Gly Phe Ser Ala Gly Met Thr Thr Leu Leu Val Gly Ala Gly Tyr 
305                 310                 315                 320 

Ala Pro Ser Glu Ala Gly Leu Ile Val Ala Val Gly Val Leu Gly Met 
                325                 330                 335     

Leu Leu Ala Gly Val Val Ala Tyr Leu Ala Gly Glu Val Met Glu Arg 
            340                 345                 350         

Lys Thr Tyr Leu Leu Val Ser Ala Val Leu Thr Ile Leu Gly Gly Leu 
        355                 360                 365             

Val Val Gly Leu Ala Gly His His Leu Trp Leu Ser Tyr Leu Gly Ala 
    370                 375                 380                 

Ile Leu Leu Phe Phe Gly Gln Asn Val Trp Val Pro Val Phe Tyr Ala 
385                 390                 395                 400 

Trp Thr Ala Glu Asn Phe Pro Ser Arg Ala Arg Thr Ser Gly Phe Ala 
                405                 410                 415     

Leu Val Asp Gly Ala Gly His Ile Gly Ala Gly Val Gly Leu Trp Ala 
            420                 425                 430         

Ile Ala Pro Leu Ile Pro Ser Leu Gly Val Thr Ala Gly Phe Val Ala 
        435                 440                 445             

Met Ser Gly Phe Leu Leu Ile Ala Ala Phe Ile Ala Leu Gly Gly Ile 
    450                 455                 460                 

Ala Ser Arg Gly Lys Val Leu Glu Glu Ile Ser Pro 
465                 470                 475     

<210>   767
<211>   1431
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   767
atgggcacgg gtgtgcctgt ttcgagcgcg gcgggcatct tggcgcggat ggagcggttg       60

accgcatggc cgcttccgcg gcgattgttc ctcgtcatcg gtctcgggta tctgttcacc      120

ttctacgaca tattcgacgt caatgtgtcc tttgtgcaga ccgccacatc catcataccc      180

ggtgcaactc cggcggacgc cagccggtac atcggattgc ccatcttcgc caacctgttg      240

gggtacgtgg tcggcacgct tgtgttgagc cctcttgccg atcgcgtcgg gcgaaggcgt      300

atgctgatga ccaccatgtt catcacgggg gtcggttctc tgttgacagc tctcgcgatg      360

cgcgactggt ggtttattct cgcgcgcggc atcacgggcg tgggcgtggc cgcggatctg      420

gctgtcgtga atacctacat gagcgaggtc gcgccgagaa gagcgagggc gaagtacacc      480

tcaggattgt tcattttctc aggtgtcgga gcgcttgtgg gcatctggct cgggttgtgg      540

ttgacgacgc ccagtgcgcc gtttccggaa ggacttccgt ttgcgcttgc aacttcgtcg      600

ttccattggg gctggcggtt gatgtactac atcggggcgg tactcgcgct catcgcactc      660

ctgctgcggc ttgagctccc tgagtctcct cgctggctgg ccgcgaaggg gcgagtcgaa      720

gaagccgccg ctgttgtagc tgctatggag gagcgcctgg gcttgggcgc gtttcaatcc      780

gatggaaccg ccgcatcgtt ctcgctggtc tccgacacgc gcgcgccgta tggcgaactg      840

tttggcagtc ctgtgtatcg caggcgaatc ttcctcctgt ttttcgtctg gctctttagc      900

tatgtgaccg tgtacggatt ttctgcaggc atgaccacgc tgctcgtggg cgcaggctat      960

gcgccgagtg aggcggggct catcgtggcc gtcggcgtct tgggcatgct gctggccggc     1020

gtcgtggcgt accttgcggg agaagtcatg gaacgcaaaa cctatctgct cgtgtctgcg     1080

gtcctgacca tcttgggagg actcgtggtg gggcttgctg gacaccatct gtggctttcg     1140

tacctcggtg caatcctcct cttcttcggg cagaacgtgt gggtgccggt gttttacgcg     1200

tggactgcgg aaaactttcc atctcgcgcg aggaccagcg gtttcgccct cgtggatgga     1260

gcgggacaca tcggcgccgg agtcggtttg tgggccatcg cgccgttgat tccctctctc     1320

ggcgtgaccg ccggatttgt ggcgatgtcg ggcttccttc tgatcgcggc gttcatcgcc     1380

cttggaggga ttgcgtctcg aggcaaagtt ttggaggaga tttcgccgta g              1431


<210>   768
<211>   470
<212>   PRT
<213>   Acidiphilium cryptum JF-5

<400>   768
Asn Thr Ala Gly Leu Leu Leu Ala Arg Leu Asp Arg Ile Pro Asn Trp 
                5                   10                  15      

Thr Leu Pro Arg Leu Tyr Ala Leu Val Ile Gly Ile Gly Phe Leu Phe 
            20                  25                  30          

Thr Phe Tyr Asp Ile Phe Asp Ile Asn Val Ser Phe Ile Gln Thr Cys 
        35                  40                  45              

Met Ala Leu Val Pro Gly Cys Thr Pro Ala Lys Ser Gly Ala Tyr Ile 
    50                  55                  60                  

Gly Leu Pro Val Leu Leu Asn Leu Ala Gly Tyr Val Val Gly Thr Leu 
65                  70                  75                  80  

Val Leu Ser Pro Leu Ala Asp Arg Met Gly Arg Arg Asp Leu Leu Leu 
                85                  90                  95      

Val Thr Met Ile Leu Thr Gly Ile Gly Ser Ala Leu Thr Ala Ile Val 
            100                 105                 110         

Gln Ser Tyr Gly Thr Phe Val Ala Ala Arg Ala Phe Thr Gly Val Gly 
        115                 120                 125             

Ile Gly Ala Asp Leu Ala Ile Val Asn Thr Tyr Ile Gly Glu Leu Ala 
    130                 135                 140                 

Pro Ala Gly Gly Arg Ala Arg Tyr Thr Ser Met Ile Phe Ile Phe Ser 
145                 150                 155                 160 

Ala Leu Gly Ala Val Ala Gly Ile Trp Leu Gly Leu Trp Leu Thr Thr 
                165                 170                 175     

Pro Pro Thr Pro Leu Pro Leu Gly Leu Pro Phe Ala Leu Ala Gly Lys 
            180                 185                 190         

Gly Phe Pro Asp Gly Trp Arg Val Met Tyr Leu Ile Gly Ala Ala Leu 
        195                 200                 205             

Ala Leu Val Gly Val Leu Leu Arg Phe Gln Leu Pro Glu Ser Pro Arg 
    210                 215                 220                 

Trp Leu Ile Ala Gln Gly Arg Leu Glu Glu Ala Gly Gln Val Val Ala 
225                 230                 235                 240 

Asp Met Glu Ala Arg Ala His Ala Ile Phe Pro Leu Pro Pro Leu Pro 
                245                 250                 255     

Glu Arg Leu Pro Pro Ala Pro Arg Arg Glu Glu Ala Met Pro Phe Ser 
            260                 265                 270         

Ala Ile Phe Arg Asn Ala Thr Tyr Arg Asn Arg Thr Leu Leu Leu Thr 
        275                 280                 285             

Val Met Trp Phe Leu Ala Tyr Ile Thr Val Tyr Ser Phe Ala Ala Gly 
    290                 295                 300                 

Phe Thr Thr Leu Leu Ala Ala Leu His Tyr Pro Pro Pro Glu Ala Gly 
305                 310                 315                 320 

Leu Ile Thr Ala Met Gly Thr Phe Gly Phe Val Leu Cys Ala Ile Val 
                325                 330                 335     

Ala Tyr Val Trp Gly Glu Arg Met Glu Arg Arg Arg Trp Thr Pro Leu 
            340                 345                 350         

Ala Ala Leu Ile Thr Leu Gly Gly Gly Val Leu Ile Ala Leu Gly Gly 
        355                 360                 365             

Gln Thr Leu Trp Leu Ser Val Ile Gly Ala Met Ile Val Phe Phe Gly 
    370                 375                 380                 

Phe Asn Val Trp Val Pro Ile Ala Tyr Ala Trp Ser Val Glu Asn Tyr 
385                 390                 395                 400 

Pro Thr Arg Ala Arg Thr Thr Gly Phe Ala Leu Val Asp Gly Ile Gly 
                405                 410                 415     

His Leu Gly Gly Gly Val Gly Met Ile Ala Ile Ala Pro Leu Ile Pro 
            420                 425                 430         

Arg Leu Gly Val Met Ala Ala Phe Leu Leu Ile Gly Gly Phe Leu Ala 
        435                 440                 445             

Leu Ala Ala Leu Val Ala Gln Phe Gly Ile Ser Thr Arg Ala Arg Arg 
    450                 455                 460                 

Leu Asp Asp Ile Ser Pro 
465                 470 

<210>   769
<211>   445
<212>   PRT
<213>   Sulfolobus solfataricus P2

<400>   769
Ala Gly Glu Ala Ile Ala Arg Met Asp Arg Ile Pro Ile Trp Gly Leu 
                5                   10                  15      

Ser Tyr Ile Phe Ile Gly Ile Leu Gly Ile Gly Phe Leu Phe Thr Phe 
            20                  25                  30          

Tyr Asp Ile Phe Asp Ile Asn Val Ser Phe Ile Gln Thr Ala Leu Thr 
        35                  40                  45              

Leu Phe His Val Ser Asn Pro Thr Ser Pro Gln Ile Pro Ala Leu Leu 
    50                  55                  60                  

Gly Pro Ile Val Leu Leu Asn Leu Val Gly Tyr Ile Ile Gly Ala Leu 
65                  70                  75                  80  

Ile Leu Ser Pro Ile Ser Asp Val Ile Gly Arg Arg Arg Met Leu Met 
                85                  90                  95      

Ile Thr Met Ile Ile Thr Gly Leu Gly Ser Leu Tyr Asn Ala Leu Ala 
            100                 105                 110         

Asn Asn Tyr Val Asn Phe Leu Val Ala Arg Thr Ile Thr Gly Ile Gly 
        115                 120                 125             

Val Gly Ala Asp Leu Ala Ile Val Asn Thr Tyr Ile Gly Glu Val Ala 
    130                 135                 140                 

Pro Ile Asn Gly Arg Ala Arg Tyr Thr Ser Leu Val Phe Leu Phe Ser 
145                 150                 155                 160 

Thr Leu Gly Ala Thr Leu Gly Ile Trp Leu Gly Leu Phe Leu Thr Thr 
                165                 170                 175     

Pro Ser Ala Pro Phe Pro Leu Gly Leu Pro Phe Ala Leu Gly Gly Ser 
            180                 185                 190         

Gly Phe Phe Ala Val Asn Gly Trp Arg Val Met Tyr Gly Ile Gly Ala 
        195                 200                 205             

Leu Leu Ala Leu Ile Gly Leu Leu Leu Arg Phe Ser Leu Pro Glu Ser 
    210                 215                 220                 

Pro Arg Trp Leu Ile Ser Lys Gly Lys Leu Thr Glu Ala Glu Arg Ile 
225                 230                 235                 240 

Val Glu Val Met Glu Lys Lys Ala Thr Gly Lys Leu Gly Asn Leu Pro 
                245                 250                 255     

Pro Leu Pro Asn Ile Ile Gln Pro Tyr Ile Ala Glu Arg Tyr Ser Tyr 
            260                 265                 270         

Leu Asp Ala Leu Lys Thr Ile Phe Ser Ser Ser Leu Tyr Ile Lys Arg 
        275                 280                 285             

Phe Gly Ile Leu Val Ser Met Trp Leu Phe Gly Tyr Met Thr Val Tyr 
    290                 295                 300                 

Thr Leu Ala Ala Gly Leu Thr Ser Val Leu Ala Ser Leu Gly Phe Ala 
305                 310                 315                 320 

Pro Pro Glu Ala Gly Met Ile Ala Ala Ile Gly Val Ile Gly Phe Ile 
                325                 330                 335     

Leu Val Pro Ile Thr Thr Phe Phe Val Gly Asp Arg Leu Glu Arg Lys 
            340                 345                 350         

Thr Trp Thr Val Ile Ser Val Val Phe Thr Ile Ile Gly Gly Leu Leu 
        355                 360                 365             

Ile Ala Ile Ala Gly Thr Asn Ile Ala Leu Ser Phe Leu Gly Ser Ile 
    370                 375                 380                 

Ile Leu Phe Tyr Gly Phe Asn Leu Trp Val Pro Thr Ser Tyr Ala Trp 
385                 390                 395                 400 

Thr Ala Glu Ser Phe Pro Thr Arg Ala Arg Ser Thr Gly Phe Ala Leu 
                405                 410                 415     

Cys Asp Gly Val Gly His Ile Gly Gly Gly Ile Gly Ile Ile Ala Ile 
            420                 425                 430         

Ser Ser Phe Ile Gly Ser Leu Ile Ala Ser Gly Val Thr 
        435                 440                 445 

<210>   770
<211>   447
<212>   PRT
<213>   Sulfolobus acidocaldarius DSM 639

<400>   770
Ala Gly Glu Ile Ile Ala Arg Met Asp Arg Ile Pro Ile Trp Gly Leu 
                5                   10                  15      

Ser Tyr Ile Phe Ile Gly Ile Leu Gly Ile Gly Phe Leu Phe Thr Phe 
            20                  25                  30          

Tyr Asp Ile Phe Asp Ile Asn Val Ser Phe Ile Gln Thr Ala Val Thr 
        35                  40                  45              

Ile Phe His Val Ser Ser Pro Ser Ser Pro Gln Ile Pro Leu Leu Leu 
    50                  55                  60                  

Gly Pro Ala Val Leu Leu Asn Leu Ile Gly Tyr Val Ile Gly Ser Leu 
65                  70                  75                  80  

Val Leu Ser Pro Val Ser Asp Ile Ile Gly Arg Arg Arg Met Leu Met 
                85                  90                  95      

Ile Thr Met Ile Ile Thr Gly Leu Gly Ser Leu Tyr Asn Thr Phe Val 
            100                 105                 110         

Asn Asp Tyr Leu Asn Phe Val Met Ala Arg Thr Ile Thr Gly Ile Gly 
        115                 120                 125             

Val Gly Ala Asp Leu Ala Ile Val Asn Thr Tyr Ile Gly Glu Val Ala 
    130                 135                 140                 

Pro Thr Asn Gly Arg Ala Lys Tyr Thr Ser Leu Val Phe Leu Phe Ser 
145                 150                 155                 160 

Thr Leu Gly Ala Thr Leu Gly Ile Trp Leu Gly Leu Leu Leu Thr Thr 
                165                 170                 175     

Pro Pro Ala Pro Phe Pro Leu Gly Leu Pro Phe Ala Leu Gly Leu Ser 
            180                 185                 190         

Gly Phe Phe Ala Val Asn Gly Trp Arg Val Met Tyr Gly Ile Gly Ala 
        195                 200                 205             

Leu Leu Ala Leu Val Gly Leu Leu Leu Arg Phe Ser Leu Pro Glu Ser 
    210                 215                 220                 

Pro Arg Trp Leu Ile Ser Arg Asn Arg Ile Ser Glu Ala Glu Lys Ile 
225                 230                 235                 240 

Val Asn Met Met Glu Asp Lys Ala Thr Lys Lys Leu Lys Gln Leu Pro 
                245                 250                 255     

Ser Leu Pro Lys Val Ile Thr Pro Tyr Leu Ser Glu Met Leu Ser Tyr 
            260                 265                 270         

Ala Asp Thr Leu Lys Thr Ile Phe Ser Asn Ser Gln Tyr Val Lys Arg 
        275                 280                 285             

Phe Val Ile Leu Phe Thr Met Trp Leu Phe Gly Tyr Met Thr Val Tyr 
    290                 295                 300                 

Thr Leu Ala Ala Gly Leu Thr Ser Val Leu Ala Ser Leu Gly Tyr Pro 
305                 310                 315                 320 

Pro Pro Glu Ala Gly Ile Ile Ala Ala Met Gly Ser Ile Gly Phe Ile 
                325                 330                 335     

Leu Val Pro Leu Thr Thr Phe Ala Val Gly Asp Arg Leu Glu Arg Lys 
            340                 345                 350         

Val Trp Thr Ala Ile Ser Val Ile Phe Thr Phe Leu Gly Gly Leu Leu 
        355                 360                 365             

Ile Ala Leu Ala Gly Thr Asn Val Val Val Ser Phe Ile Gly Ser Ile 
    370                 375                 380                 

Ile Leu Phe Tyr Gly Phe Asn Leu Trp Val Pro Ile Ser Tyr Ala Trp 
385                 390                 395                 400 

Thr Ala Glu Ser Phe Pro Thr Arg Ala Arg Ser Thr Gly Phe Ala Leu 
                405                 410                 415     

Cys Asp Gly Ile Gly His Val Gly Gly Gly Ile Gly Leu Ile Ile Ile 
            420                 425                 430         

Ala Ser Phe Ile Ser Ser Leu Leu Ser Ser Gly Val Thr Thr Gly 
        435                 440                 445         

<210>   771
<211>   472
<212>   PRT
<213>   Sulfolobus tokodaii str. 7

<400>   771
Thr Lys Ser Ser Glu Ile Ile Ala Arg Leu Asp Arg Leu Pro Thr Trp 
                5                   10                  15      

Ala Phe Asn Tyr Ile Leu Leu Gly Ile Ile Gly Val Gly Glu Leu Phe 
            20                  25                  30          

Thr Phe Tyr Asp Ile Phe Asn Ile Asn Val Ser Phe Val Gln Thr Ala 
        35                  40                  45              

Val Thr Leu Phe His Val Ser Pro Ala Gln Ala Ala Gln Leu Leu Gly 
    50                  55                  60                  

Pro Val Val Leu Gly Asn Leu Val Gly Tyr Val Val Gly Ser Leu Val 
65                  70                  75                  80  

Leu Ser Pro Ile Ala Asp Arg Ile Gly Arg Arg Asp Met Leu Met Ile 
                85                  90                  95      

Thr Met Leu Ile Met Gly Leu Ser Ser Leu Tyr Asn Ala Phe Ala Pro 
            100                 105                 110         

Asn Tyr Ile Asn Phe Phe Ile Ala Arg Thr Leu Thr Gly Ile Gly Val 
        115                 120                 125             

Gly Ala Asp Leu Ala Ile Val Asn Thr Tyr Ile Ser Glu Val Ala Pro 
    130                 135                 140                 

Leu Ala Tyr Arg Ser Lys Tyr Val Ser Ala Ile Phe Ile Phe Ser Thr 
145                 150                 155                 160 

Val Gly Gly Phe Leu Ala Ile Trp Leu Gly Leu Leu Phe Thr Thr Pro 
                165                 170                 175     

Pro Ala Pro Phe Pro Gln Gly Leu Pro Ile Ala Leu Gly Gly Ser Gly 
            180                 185                 190         

Phe Phe Ala Ile Asn Gly Trp Arg Val Met Tyr Ile Ile Gly Ala Val 
        195                 200                 205             

Leu Ala Leu Ile Gly Leu Ala Leu Arg Phe Arg Leu Pro Glu Ser Pro 
    210                 215                 220                 

Arg Trp Leu Ile Ser Lys Gly Arg Val Ser Glu Ala Glu Met Ile Val 
225                 230                 235                 240 

Asn Leu Met Glu Glu Lys Val Thr Ser Arg Gly Tyr Lys Leu Pro Pro 
                245                 250                 255     

Leu Pro Ser Leu Ile Pro Ile Tyr Lys Ala Ser Lys Pro Val Pro Tyr 
            260                 265                 270         

Ser Glu Ile Phe Thr Asn Ser Thr Tyr Leu Lys Arg Phe Ile Thr Leu 
        275                 280                 285             

Val Ile Val Trp Phe Leu Ala Tyr Thr Thr Val Tyr Ser Ile Ala Ala 
    290                 295                 300                 

Gly Leu Thr Ser Leu Leu Thr Ala Gln Gly Tyr Ser Thr Ser Glu Ala 
305                 310                 315                 320 

Gly Met Ile Ser Ala Ile Gly Ile Ile Gly Phe Ile Leu Ala Ala Val 
                325                 330                 335     

Ile Ala Thr Leu Phe Gly Asp Arg Leu Glu Arg Lys Trp Trp Ile Gly 
            340                 345                 350         

Ile Gly Ala Leu Val Thr Val Ile Gly Gly Met Met Val Ala Leu Thr 
        355                 360                 365             

Pro Asn Pro Ile Ile Asp Gly Leu Gly Ala Ile Ile Leu Phe Ile Gly 
    370                 375                 380                 

Phe Asn Val Trp Val Pro Val Ala Tyr Thr Trp Thr Ala Glu Ser Phe 
385                 390                 395                 400 

Pro Thr Arg Ala Arg Thr Ser Gly Phe Ala Leu Cys Asp Gly Phe Gly 
                405                 410                 415     

His Leu Gly Gly Gly Leu Gly Val Val Tyr Ile Thr Ser Val Ala Thr 
            420                 425                 430         

Thr Leu His Ser Thr Val Glu Leu Phe Gly Leu Ile Ala Gly Phe Leu 
        435                 440                 445             

Val Val Ala Ala Ile Ile Ala Met Val Thr Gly His Tyr Thr Leu Gly 
    450                 455                 460                 

Lys Arg Leu Asp Glu Ile Ser Pro 
465                 470         

<210>   772
<211>   484
<212>   PRT
<213>   Metallosphaera sedula DSM 5348

<400>   772
Asn Ala Ser Glu Ile Ile Ala Arg Leu Asp Arg Leu Pro Val Trp Ser 
                5                   10                  15      

Leu Pro Ala Thr Phe Ile Ala Val Leu Gly Thr Gly Phe Leu Phe Thr 
            20                  25                  30          

Phe Phe Asp Ile Phe Asp Ile Asn Val Ser Phe Ile Gln Thr Ala Leu 
        35                  40                  45              

Thr Thr Phe Gly Val Ser Ser Pro Ser Ser Pro Glu Ile Pro Gln Leu 
    50                  55                  60                  

Leu Gly Pro Val Val Leu Trp Asn Leu Val Gly Tyr Val Ile Gly Ala 
65                  70                  75                  80  

Leu Ala Leu Thr Pro Leu Ala Asp Arg Tyr Gly Arg Lys Arg Met Leu 
                85                  90                  95      

Met Ile Thr Met Ala Ile Thr Gly Leu Gly Ser Leu Tyr Asn Ala Leu 
            100                 105                 110         

Ser Pro Asp Tyr Leu Asn Tyr Leu Leu Ala Arg Thr Ile Thr Gly Ile 
        115                 120                 125             

Gly Val Gly Ala Asp Leu Ala Ile Val Asn Thr Tyr Ile Asn Glu Val 
    130                 135                 140                 

Ser Pro Val Asn Gly Arg Ala Lys Phe Thr Ser Leu Val Phe Leu Phe 
145                 150                 155                 160 

Ala Thr Leu Gly Ala Phe Leu Gly Leu Trp Leu Gly Leu Leu Ile Thr 
                165                 170                 175     

Thr Pro Pro Ala Pro Phe Pro Leu Gly Leu Pro Phe Ala Leu Gly Thr 
            180                 185                 190         

Thr Gly Ile Phe Ala Thr Ala Gly Trp Arg Ile Met Tyr Gly Ile Gly 
        195                 200                 205             

Ser Leu Leu Ala Leu Ile Gly Leu Leu Leu Arg Val Glu Leu Pro Glu 
    210                 215                 220                 

Ser Pro Arg Trp Leu Ala Ser Lys Gly Arg Ile Met Glu Ala Ser Lys 
225                 230                 235                 240 

Ile Val Glu Arg Met Glu Glu Ala Ala Arg Lys Lys Ile Gly Glu Leu 
                245                 250                 255     

Pro Pro Val Pro Gln His Ile Glu Val Lys Thr Ile Thr Glu Val Ser 
            260                 265                 270         

Tyr Lys Glu Ala Leu Arg Thr Ile Leu Gly Asn Arg Val Tyr Leu Lys 
        275                 280                 285             

Arg Trp Ile Ile Val Met Ser Met Trp Phe Phe Gly Tyr Ile Thr Val 
    290                 295                 300                 

Tyr Thr Asn Ala Ala Gly Leu Thr Thr Ile Leu Ser Ser Leu Gly Tyr 
305                 310                 315                 320 

Pro Ser Ser Glu Ala Gly Met Ile Ala Ser Leu Gly Ile Leu Gly Phe 
                325                 330                 335     

Val Ala Val Pro Val Leu Leu Ile Leu Phe Gly Asp Arg Leu Glu Arg 
            340                 345                 350         

Lys Val Trp Val Pro Ile Ser Ala Val Ile Met Leu Leu Gly Gly Ala 
        355                 360                 365             

Ile Met Ala Glu Ala Gly His Asn Phe Phe Leu Glu Val Leu Gly Ala 
    370                 375                 380                 

Phe Val Leu Phe Phe Gly Asn Asn Leu Trp Ile Pro Ile Ser Tyr Ala 
385                 390                 395                 400 

Trp Thr Thr Glu Asn Phe Pro Thr Arg Ala Arg Val Thr Gly Phe Gly 
                405                 410                 415     

Leu Ala Asp Gly Ile Gly His Ile Gly Gly Gly Ile Gly Ala Phe Leu 
            420                 425                 430         

Val Ala Leu Gln Ile Gly Asn Ile Val Ser His Gly Val Thr Ser Asn 
        435                 440                 445             

Thr Pro Leu Glu Val Phe Met Leu Met Ile Ser Phe Gln Leu Leu Ser 
    450                 455                 460                 

Ala Leu Ile Ser Leu Ala Gly Ile Arg Thr Ala Lys Arg Arg Leu Asp 
465                 470                 475                 480 

Glu Ile Ser Pro 
                

<210>   773
<211>   476
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   773
Met Gly Thr Gly Val Pro Val Ser Ser Ala Ala Gly Ile Leu Ala Arg 
                5                   10                  15      

Met Glu Arg Leu Thr Ala Trp Pro Leu Pro Arg Arg Leu Phe Leu Val 
            20                  25                  30          

Ile Gly Leu Gly Tyr Leu Phe Thr Phe Tyr Asp Ile Phe Asp Val Asn 
        35                  40                  45              

Val Ser Phe Val Gln Thr Ala Thr Ser Ile Ile Pro Gly Ala Thr Pro 
    50                  55                  60                  

Ala Asp Ala Ser Arg Tyr Ile Gly Leu Pro Ile Phe Ala Asn Leu Leu 
65                  70                  75                  80  

Gly Tyr Val Ile Gly Thr Leu Val Leu Ser Pro Leu Ala Asp Arg Val 
                85                  90                  95      

Gly Arg Arg Arg Met Leu Met Thr Thr Met Phe Ile Thr Gly Val Gly 
            100                 105                 110         

Ser Leu Leu Thr Ala Leu Ala Met Arg Asp Trp Trp Phe Ile Leu Ala 
        115                 120                 125             

Arg Gly Ile Thr Gly Val Gly Val Ala Ala Asp Leu Ala Val Val Asn 
    130                 135                 140                 

Thr Tyr Met Ser Glu Val Ala Pro Arg Arg Ala Arg Ala Lys Tyr Thr 
145                 150                 155                 160 

Ser Gly Leu Phe Ile Phe Ser Gly Val Gly Ala Leu Val Gly Ile Trp 
                165                 170                 175     

Leu Gly Leu Trp Leu Thr Thr Pro Ser Ala Pro Phe Pro Glu Gly Leu 
            180                 185                 190         

Pro Phe Ala Leu Ala Thr Ser Ser Phe His Trp Gly Trp Arg Leu Met 
        195                 200                 205             

Tyr Tyr Ile Gly Ala Val Leu Ala Leu Ile Ala Leu Leu Leu Arg Leu 
    210                 215                 220                 

Glu Leu Pro Glu Ser Pro Arg Trp Leu Ala Ala Lys Gly Arg Val Glu 
225                 230                 235                 240 

Glu Ala Ala Ala Val Val Ala Ala Met Glu Glu Arg Leu Gly Leu Gly 
                245                 250                 255     

Ala Phe Gln Ser Asp Gly Thr Ala Ala Ser Phe Ser Leu Val Ser Asp 
            260                 265                 270         

Thr Arg Ala Pro Tyr Gly Glu Leu Phe Gly Ser Pro Val Tyr Arg Arg 
        275                 280                 285             

Arg Ile Phe Leu Leu Phe Phe Val Trp Leu Phe Ser Tyr Val Thr Val 
    290                 295                 300                 

Tyr Gly Phe Ser Ala Gly Met Thr Thr Leu Leu Val Gly Ala Gly Tyr 
305                 310                 315                 320 

Ala Pro Ser Glu Ala Gly Leu Ile Val Ala Val Gly Val Leu Gly Met 
                325                 330                 335     

Leu Leu Ala Gly Val Val Ala Tyr Leu Ala Gly Glu Val Met Glu Arg 
            340                 345                 350         

Lys Thr Tyr Leu Leu Val Ser Ala Val Leu Thr Ile Leu Gly Gly Leu 
        355                 360                 365             

Val Val Gly Leu Ala Gly His His Leu Trp Leu Ser Tyr Leu Gly Ala 
    370                 375                 380                 

Ile Leu Leu Phe Phe Gly Gln Asn Val Trp Val Pro Val Phe Tyr Ala 
385                 390                 395                 400 

Trp Thr Ala Glu Asn Phe Pro Ser Arg Ala Arg Thr Ser Gly Phe Ala 
                405                 410                 415     

Leu Val Asp Gly Ala Gly His Ile Gly Ala Gly Val Gly Leu Trp Ala 
            420                 425                 430         

Ile Ala Pro Leu Ile Pro Ser Leu Gly Val Thr Ala Gly Phe Val Ala 
        435                 440                 445             

Met Ser Gly Phe Leu Leu Ile Ala Ala Phe Ile Ala Leu Gly Gly Ile 
    450                 455                 460                 

Ala Ser Arg Gly Lys Val Leu Glu Glu Ile Ser Pro 
465                 470                 475     

<210>   774
<211>   476
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   774
Met Gly Thr Gly Val Pro Val Ser Ser Ala Ala Gly Ile Leu Ala Arg 
                5                   10                  15      

Met Glu Arg Leu Thr Ala Trp Pro Leu Pro Arg Arg Leu Phe Leu Val 
            20                  25                  30          

Ile Gly Leu Gly Tyr Leu Phe Thr Phe Tyr Asp Ile Phe Asp Val Asn 
        35                  40                  45              

Val Ser Phe Val Gln Thr Ala Thr Ser Ile Ile Pro Gly Ala Thr Pro 
    50                  55                  60                  

Ala Asp Ala Ser Arg Tyr Ile Gly Leu Pro Ile Phe Ala Asn Leu Leu 
65                  70                  75                  80  

Gly Tyr Val Val Gly Thr Leu Val Leu Ser Pro Leu Ala Asp Arg Val 
                85                  90                  95      

Gly Arg Arg Arg Met Leu Met Thr Thr Met Phe Ile Thr Gly Val Gly 
            100                 105                 110         

Ser Leu Leu Thr Ala Leu Ala Met Arg Asp Trp Trp Phe Ile Leu Ala 
        115                 120                 125             

Arg Gly Ile Thr Gly Val Gly Val Ala Ala Asp Leu Ala Val Val Asn 
    130                 135                 140                 

Thr Tyr Met Ser Glu Val Ala Pro Arg Arg Ala Arg Ala Lys Tyr Thr 
145                 150                 155                 160 

Ser Gly Leu Phe Ile Phe Ser Gly Val Gly Ala Leu Val Gly Ile Trp 
                165                 170                 175     

Leu Gly Leu Trp Leu Thr Thr Pro Ser Ala Pro Phe Pro Glu Gly Leu 
            180                 185                 190         

Pro Phe Ala Leu Ala Thr Ser Ser Phe His Trp Gly Trp Arg Leu Met 
        195                 200                 205             

Tyr Tyr Ile Gly Ala Val Leu Ala Leu Ile Ala Leu Leu Leu Arg Leu 
    210                 215                 220                 

Glu Leu Pro Glu Ser Pro Arg Trp Leu Ala Ala Lys Gly Arg Val Glu 
225                 230                 235                 240 

Glu Ala Ala Ala Val Val Ala Ala Met Glu Glu Arg Leu Gly Leu Gly 
                245                 250                 255     

Ala Phe Gln Ser Asp Gly Thr Ala Ala Ser Phe Ser Leu Val Ser Asp 
            260                 265                 270         

Thr Arg Ala Pro Tyr Gly Glu Leu Phe Gly Ser Pro Val Tyr Arg Arg 
        275                 280                 285             

Arg Ile Phe Leu Leu Phe Phe Val Trp Leu Phe Ser Tyr Val Thr Val 
    290                 295                 300                 

Tyr Gly Phe Ser Ala Gly Met Thr Thr Leu Leu Val Gly Ala Gly Tyr 
305                 310                 315                 320 

Ala Pro Ser Glu Ala Gly Leu Ile Ile Ala Val Gly Val Leu Gly Met 
                325                 330                 335     

Leu Leu Ala Gly Val Val Ala Tyr Leu Ala Gly Glu Val Met Glu Arg 
            340                 345                 350         

Lys Thr Tyr Leu Leu Val Ser Ala Val Leu Thr Ile Leu Gly Gly Leu 
        355                 360                 365             

Val Val Gly Leu Ala Gly His His Leu Trp Leu Ser Tyr Leu Gly Ala 
    370                 375                 380                 

Ile Leu Leu Phe Phe Gly Gln Asn Val Trp Val Pro Val Phe Tyr Ala 
385                 390                 395                 400 

Trp Thr Ala Glu Asn Phe Pro Ser Arg Ala Arg Thr Ser Gly Phe Ala 
                405                 410                 415     

Leu Val Asp Gly Ala Gly His Ile Gly Ala Gly Val Gly Leu Trp Ala 
            420                 425                 430         

Ile Ala Pro Leu Ile Pro Ser Leu Gly Val Thr Ala Gly Phe Val Ala 
        435                 440                 445             

Met Ser Gly Phe Leu Leu Ile Ala Ala Phe Ile Ala Leu Gly Gly Ile 
    450                 455                 460                 

Ala Ser Arg Gly Lys Val Leu Glu Glu Ile Ser Pro 
465                 470                 475     

<210>   775
<211>   476
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   775
Met Gly Thr Gly Val Pro Val Ser Ser Ala Ala Gly Ile Leu Ala Arg 
                5                   10                  15      

Met Glu Arg Leu Thr Ala Trp Pro Leu Pro Arg Arg Leu Phe Leu Val 
            20                  25                  30          

Ile Gly Leu Gly Tyr Leu Phe Thr Phe Tyr Asp Ile Phe Asp Val Asn 
        35                  40                  45              

Val Ser Phe Val Gln Thr Ala Thr Ser Ile Ile Pro Gly Ala Thr Pro 
    50                  55                  60                  

Ala Asp Ala Ser Arg Tyr Ile Gly Leu Pro Ile Phe Ala Asn Leu Leu 
65                  70                  75                  80  

Gly Tyr Val Val Gly Thr Leu Val Leu Ser Pro Leu Ala Asp Arg Val 
                85                  90                  95      

Gly Arg Arg Arg Met Leu Met Thr Thr Met Phe Ile Thr Gly Val Gly 
            100                 105                 110         

Ser Leu Leu Thr Ala Leu Ala Met Arg Asp Trp Trp Phe Ile Leu Ala 
        115                 120                 125             

Arg Gly Ile Thr Gly Val Gly Val Ala Ala Asp Leu Ala Val Val Asn 
    130                 135                 140                 

Thr Tyr Met Ser Glu Val Ala Pro Arg Arg Ala Arg Ala Lys Tyr Thr 
145                 150                 155                 160 

Ser Gly Leu Phe Ile Phe Ser Gly Val Gly Ala Leu Val Gly Ile Trp 
                165                 170                 175     

Leu Gly Leu Trp Leu Thr Thr Pro Ser Ala Pro Phe Pro Glu Gly Leu 
            180                 185                 190         

Pro Phe Ala Leu Ala Thr Ser Ser Phe His Trp Gly Trp Arg Leu Met 
        195                 200                 205             

Tyr Tyr Ile Gly Ala Val Leu Ala Leu Ile Ala Leu Leu Leu Arg Leu 
    210                 215                 220                 

Glu Leu Pro Glu Ser Pro Arg Trp Leu Ala Ala Lys Gly Arg Val Glu 
225                 230                 235                 240 

Glu Ala Ala Ala Val Val Ala Ala Met Glu Glu Arg Leu Gly Leu Gly 
                245                 250                 255     

Ala Phe Gln Ser Asp Gly Thr Ala Ala Ser Phe Ser Leu Val Ser Asp 
            260                 265                 270         

Thr Lys Ala Pro Tyr Gly Glu Leu Phe Gly Ser Pro Val Tyr Arg Arg 
        275                 280                 285             

Arg Ile Phe Leu Leu Phe Phe Val Trp Leu Phe Ser Tyr Val Thr Val 
    290                 295                 300                 

Tyr Gly Phe Ser Ala Gly Met Thr Thr Leu Leu Val Gly Ala Gly Tyr 
305                 310                 315                 320 

Ala Pro Ser Glu Ala Gly Leu Ile Val Ala Val Gly Val Leu Gly Met 
                325                 330                 335     

Leu Leu Ala Gly Val Val Ala Tyr Leu Ala Gly Glu Val Met Glu Arg 
            340                 345                 350         

Lys Thr Tyr Leu Leu Val Ser Ala Val Leu Thr Ile Leu Gly Gly Leu 
        355                 360                 365             

Val Val Gly Leu Ala Gly His His Leu Trp Leu Ser Tyr Leu Gly Ala 
    370                 375                 380                 

Ile Leu Leu Phe Phe Gly Gln Asn Val Trp Val Pro Val Phe Tyr Ala 
385                 390                 395                 400 

Trp Thr Ala Glu Asn Phe Pro Ser Arg Ala Arg Thr Ser Gly Phe Ala 
                405                 410                 415     

Leu Val Asp Gly Ala Gly His Ile Gly Ala Gly Val Gly Leu Trp Ala 
            420                 425                 430         

Ile Ala Pro Leu Ile Pro Ser Leu Gly Val Thr Ala Gly Phe Val Ala 
        435                 440                 445             

Met Ser Gly Phe Leu Leu Ile Ala Ala Phe Ile Ala Leu Gly Gly Ile 
    450                 455                 460                 

Ala Ser Arg Gly Lys Val Leu Glu Glu Ile Ser Pro 
465                 470                 475     

<210>   776
<211>   476
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   776
Met Gly Thr Gly Val Pro Val Ser Ser Ala Ala Gly Ile Leu Ala Arg 
                5                   10                  15      

Met Glu Arg Leu Thr Ala Trp Pro Leu Pro Arg Arg Leu Phe Leu Val 
            20                  25                  30          

Ile Gly Leu Gly Tyr Leu Phe Thr Phe Tyr Asp Ile Phe Asp Val Asn 
        35                  40                  45              

Val Ser Phe Val Gln Thr Ala Thr Ser Ile Ile Pro Gly Ala Thr Pro 
    50                  55                  60                  

Ala Asp Ala Ser Arg Tyr Ile Gly Leu Pro Ile Phe Ala Asn Leu Leu 
65                  70                  75                  80  

Gly Tyr Val Val Gly Thr Leu Val Leu Ser Pro Leu Ala Asp Arg Val 
                85                  90                  95      

Gly Arg Arg Arg Met Leu Met Thr Thr Met Phe Ile Thr Gly Val Gly 
            100                 105                 110         

Ser Leu Leu Thr Ala Leu Ala Met Arg Asp Trp Trp Phe Ile Leu Ala 
        115                 120                 125             

Arg Gly Ile Thr Gly Val Gly Val Ala Ala Asp Leu Ala Val Val Asn 
    130                 135                 140                 

Thr Tyr Met Ser Glu Val Ala Pro Arg Arg Ala Arg Ala Lys Tyr Thr 
145                 150                 155                 160 

Ser Gly Leu Phe Ile Phe Ser Gly Val Gly Ala Leu Val Gly Ile Trp 
                165                 170                 175     

Leu Gly Leu Trp Leu Thr Thr Pro Ser Ala Pro Phe Pro Glu Gly Leu 
            180                 185                 190         

Pro Phe Ala Leu Ala Thr Ser Ser Phe His Trp Gly Trp Arg Leu Met 
        195                 200                 205             

Tyr Tyr Ile Gly Ala Val Leu Ala Leu Ile Ala Leu Leu Leu Arg Ile 
    210                 215                 220                 

Glu Leu Pro Glu Ser Pro Arg Trp Leu Ala Ala Lys Gly Arg Val Glu 
225                 230                 235                 240 

Glu Ala Ala Ala Val Val Ala Ala Met Glu Glu Arg Leu Gly Leu Gly 
                245                 250                 255     

Ala Phe Gln Ser Asp Gly Thr Ala Ala Ser Phe Ser Leu Val Ser Asp 
            260                 265                 270         

Thr Arg Ala Pro Tyr Gly Glu Leu Phe Gly Ser Pro Val Tyr Arg Arg 
        275                 280                 285             

Arg Ile Phe Leu Leu Phe Phe Val Trp Leu Phe Ser Tyr Val Thr Val 
    290                 295                 300                 

Tyr Gly Phe Ser Ala Gly Met Thr Thr Leu Leu Val Gly Ala Gly Tyr 
305                 310                 315                 320 

Ala Pro Ser Glu Ala Gly Leu Ile Val Ala Val Gly Val Leu Gly Met 
                325                 330                 335     

Leu Leu Ala Gly Val Val Ala Tyr Leu Ala Gly Glu Val Met Glu Arg 
            340                 345                 350         

Lys Thr Tyr Leu Leu Val Ser Ala Val Leu Thr Ile Leu Gly Gly Leu 
        355                 360                 365             

Val Val Gly Leu Ala Gly His His Leu Trp Leu Ser Tyr Leu Gly Ala 
    370                 375                 380                 

Ile Leu Leu Phe Phe Gly Gln Asn Val Trp Val Pro Val Phe Tyr Ala 
385                 390                 395                 400 

Trp Thr Ala Glu Asn Phe Pro Ser Arg Ala Arg Thr Ser Gly Phe Ala 
                405                 410                 415     

Leu Val Asp Gly Ala Gly His Ile Gly Ala Gly Val Gly Leu Trp Ala 
            420                 425                 430         

Ile Ala Pro Leu Ile Pro Ser Leu Gly Val Thr Ala Gly Phe Val Ala 
        435                 440                 445             

Met Ser Gly Phe Leu Leu Ile Ala Ala Phe Ile Ala Leu Gly Gly Ile 
    450                 455                 460                 

Ala Ser Arg Gly Lys Val Leu Glu Glu Ile Ser Pro 
465                 470                 475     

<210>   777
<211>   476
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 766

<400>   777
Met Gly Thr Gly Val Pro Val Ser Ser Ala Ala Gly Ile Leu Ala Arg 
                5                   10                  15      

Met Glu Arg Leu Thr Ala Trp Pro Leu Pro Arg Arg Leu Phe Leu Val 
            20                  25                  30          

Ile Gly Leu Gly Tyr Leu Phe Thr Phe Tyr Asp Ile Phe Asp Ile Asn 
        35                  40                  45              

Val Ser Phe Val Gln Thr Ala Thr Ser Ile Ile Pro Gly Ala Thr Pro 
    50                  55                  60                  

Ala Asp Ala Ser Arg Tyr Ile Gly Leu Pro Ile Phe Ala Asn Leu Leu 
65                  70                  75                  80  

Gly Tyr Val Val Gly Thr Leu Val Leu Ser Pro Leu Ala Asp Arg Val 
                85                  90                  95      

Gly Arg Arg Arg Met Leu Met Thr Thr Met Phe Ile Thr Gly Val Gly 
            100                 105                 110         

Ser Leu Leu Thr Ala Leu Ala Met Arg Asp Trp Trp Phe Ile Leu Ala 
        115                 120                 125             

Arg Gly Ile Thr Gly Val Gly Val Ala Ala Asp Leu Ala Val Val Asn 
    130                 135                 140                 

Thr Tyr Met Ser Glu Val Ala Pro Arg Arg Ala Arg Ala Lys Tyr Thr 
145                 150                 155                 160 

Ser Gly Leu Phe Ile Phe Ser Gly Val Gly Ala Leu Val Gly Ile Trp 
                165                 170                 175     

Leu Gly Leu Trp Leu Thr Thr Pro Ser Ala Pro Phe Pro Glu Gly Leu 
            180                 185                 190         

Pro Phe Ala Leu Ala Thr Ser Ser Phe His Trp Gly Trp Arg Leu Met 
        195                 200                 205             

Tyr Tyr Ile Gly Ala Val Leu Ala Leu Ile Ala Leu Leu Leu Arg Leu 
    210                 215                 220                 

Glu Leu Pro Glu Ser Pro Arg Trp Leu Ala Ala Lys Gly Arg Val Glu 
225                 230                 235                 240 

Glu Ala Ala Ala Val Val Ala Ala Met Glu Glu Arg Leu Gly Leu Gly 
                245                 250                 255     

Ala Phe Gln Ser Asp Gly Thr Ala Ala Ser Phe Ser Leu Val Ser Asp 
            260                 265                 270         

Thr Arg Ala Pro Tyr Gly Glu Leu Phe Gly Ser Pro Val Tyr Arg Arg 
        275                 280                 285             

Arg Ile Phe Leu Leu Phe Phe Val Trp Leu Phe Ser Tyr Val Thr Val 
    290                 295                 300                 

Tyr Gly Phe Ser Ala Gly Met Thr Thr Leu Leu Val Gly Ala Gly Tyr 
305                 310                 315                 320 

Ala Pro Ser Glu Ala Gly Leu Ile Val Ala Val Gly Val Leu Gly Met 
                325                 330                 335     

Leu Leu Ala Gly Val Val Ala Tyr Leu Ala Gly Glu Val Met Glu Arg 
            340                 345                 350         

Lys Thr Tyr Leu Leu Val Ser Ala Val Leu Thr Ile Leu Gly Gly Leu 
        355                 360                 365             

Val Val Gly Leu Ala Gly His His Leu Trp Leu Ser Tyr Leu Gly Ala 
    370                 375                 380                 

Ile Leu Leu Phe Phe Gly Gln Asn Val Trp Val Pro Val Phe Tyr Ala 
385                 390                 395                 400 

Trp Thr Ala Glu Asn Phe Pro Ser Arg Ala Arg Thr Ser Gly Phe Ala 
                405                 410                 415     

Leu Val Asp Gly Ala Gly His Ile Gly Ala Gly Val Gly Leu Trp Ala 
            420                 425                 430         

Ile Ala Pro Leu Ile Pro Ser Leu Gly Val Thr Ala Gly Phe Val Ala 
        435                 440                 445             

Met Ser Gly Phe Leu Leu Ile Ala Ala Phe Ile Ala Leu Gly Gly Ile 
    450                 455                 460                 

Ala Ser Arg Gly Lys Val Leu Glu Glu Ile Ser Pro 
465                 470                 475     

<210>   778
<211>   1431
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   778
atgggcacgg gtgtgcctgt ttcgagcgcg gcgggcatct tggcgcggat ggagcggttg       60

accgcatggc cgcttccgcg gcgattgttc ctcgtcatcg gtctcgggta tctgttcacc      120

ttctacgaca tattcgacgt caatgtgtcc tttgtgcaga ccgccacatc catcataccc      180

ggtgcaactc cggcggacgc cagccggtac atcggattgc ccatcttcgc caacctgttg      240

gggtacgtga ttggcacgct tgtgttgagc cctcttgccg atcgcgtcgg gcgaaggcgt      300

atgctgatga ccaccatgtt catcacgggg gtcggttctc tgttgacagc tctcgcgatg      360

cgcgactggt ggtttattct cgcgcgcggc atcacgggcg tgggcgtggc cgcggatctg      420

gctgtcgtga atacctacat gagcgaggtc gcgccgagaa gagcgagggc gaagtacacc      480

tcaggattgt tcattttctc aggtgtcgga gcgcttgtgg gcatctggct cgggttgtgg      540

ttgacgacgc ccagtgcgcc gtttccggaa ggacttccgt ttgcgcttgc aacttcgtcg      600

ttccattggg gctggcggtt gatgtactac atcggggcgg tactcgcgct catcgcactc      660

ctgctgcggc ttgagctccc tgagtctcct cgctggctgg ccgcgaaggg gcgagtcgaa      720

gaagccgccg ctgttgtagc tgctatggag gagcgcctgg gcttgggcgc gtttcaatcc      780

gatggaaccg ccgcatcgtt ctcgctggtc tccgacacgc gcgcgccgta tggcgaactg      840

tttggcagtc ctgtgtatcg caggcgaatc ttcctcctgt ttttcgtctg gctctttagc      900

tatgtgaccg tgtacggatt ttctgcaggc atgaccacgc tgctcgtggg cgcaggctat      960

gcgccgagtg aggcggggct catcgtggcc gtcggcgtct tgggcatgct gctggccggc     1020

gtcgtggcgt accttgcggg agaagtcatg gaacgcaaaa cctatctgct cgtgtctgcg     1080

gtcctgacca tcttgggagg actcgtggtg gggcttgctg gacaccatct gtggctttcg     1140

tacctcggtg caatcctcct cttcttcggg cagaacgtgt gggtgccggt gttttacgcg     1200

tggactgcgg aaaactttcc atctcgcgcg aggaccagcg gtttcgccct cgtggatgga     1260

gcgggacaca tcggcgccgg agtcggtttg tgggccatcg cgccgttgat tccctctctc     1320

ggcgtgaccg ccggatttgt ggcgatgtcg ggcttccttc tgatcgcggc gttcatcgcc     1380

cttggaggga ttgcgtctcg aggcaaagtt ttggaggaga tttcgccgta g              1431


<210>   779
<211>   1431
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   779
atgggcacgg gtgtgcctgt ttcgagcgcg gcgggcatct tggcgcggat ggagcggttg       60

accgcatggc cgcttccgcg gcgattgttc ctcgtcatcg gtctcgggta tctgttcacc      120

ttctacgaca tattcgacgt caatgtgtcc tttgtgcaga ccgccacatc catcataccc      180

ggtgcaactc cggcggacgc cagccggtac atcggattgc ccatcttcgc caacctgttg      240

gggtacgtgg tcggcacgct tgtgttgagc cctcttgccg atcgcgtcgg gcgaaggcgt      300

atgctgatga ccaccatgtt catcacgggg gtcggttctc tgttgacagc tctcgcgatg      360

cgcgactggt ggtttattct cgcgcgcggc atcacgggcg tgggcgtggc cgcggatctg      420

gctgtcgtga atacctacat gagcgaggtc gcgccgagaa gagcgagggc gaagtacacc      480

tcaggattgt tcattttctc aggtgtcgga gcgcttgtgg gcatctggct cgggttgtgg      540

ttgacgacgc ccagtgcgcc gtttccggaa ggacttccgt ttgcgcttgc aacttcgtcg      600

ttccattggg gctggcggtt gatgtactac atcggggcgg tactcgcgct catcgcactc      660

ctgctgcggc ttgagctccc tgagtctcct cgctggctgg ccgcgaaggg gcgagtcgaa      720

gaagccgccg ctgttgtagc tgctatggag gagcgcctgg gcttgggcgc gtttcaatcc      780

gatggaaccg ccgcatcgtt ctcgctggtc tccgacacgc gcgcgccgta tggcgaactg      840

tttggcagtc ctgtgtatcg caggcgaatc ttcctcctgt ttttcgtctg gctctttagc      900

tatgtgaccg tgtacggatt ttctgcaggc atgaccacgc tgctcgtggg cgcaggctat      960

gcgccgagtg aggcggggct catcattgcc gtcggcgtct tgggcatgct gctggccggc     1020

gtcgtggcgt accttgcggg agaagtcatg gaacgcaaaa cctatctgct cgtgtctgcg     1080

gtcctgacca tcttgggagg actcgtggtg gggcttgctg gacaccatct gtggctttcg     1140

tacctcggtg caatcctcct cttcttcggg cagaacgtgt gggtgccggt gttttacgcg     1200

tggactgcgg aaaactttcc atctcgcgcg aggaccagcg gtttcgccct cgtggatgga     1260

gcgggacaca tcggcgccgg agtcggtttg tgggccatcg cgccgttgat tccctctctc     1320

ggcgtgaccg ccggatttgt ggcgatgtcg ggcttccttc tgatcgcggc gttcatcgcc     1380

cttggaggga ttgcgtctcg aggcaaagtt ttggaggaga tttcgccgta g              1431


<210>   780
<211>   1431
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   780
atgggcacgg gtgtgcctgt ttcgagcgcg gcgggcatct tggcgcggat ggagcggttg       60

accgcatggc cgcttccgcg gcgattgttc ctcgtcatcg gtctcgggta tctgttcacc      120

ttctacgaca tattcgacgt caatgtgtcc tttgtgcaga ccgccacatc catcataccc      180

ggtgcaactc cggcggacgc cagccggtac atcggattgc ccatcttcgc caacctgttg      240

gggtacgtgg tcggcacgct tgtgttgagc cctcttgccg atcgcgtcgg gcgaaggcgt      300

atgctgatga ccaccatgtt catcacgggg gtcggttctc tgttgacagc tctcgcgatg      360

cgcgactggt ggtttattct cgcgcgcggc atcacgggcg tgggcgtggc cgcggatctg      420

gctgtcgtga atacctacat gagcgaggtc gcgccgagaa gagcgagggc gaagtacacc      480

tcaggattgt tcattttctc aggtgtcgga gcgcttgtgg gcatctggct cgggttgtgg      540

ttgacgacgc ccagtgcgcc gtttccggaa ggacttccgt ttgcgcttgc aacttcgtcg      600

ttccattggg gctggcggtt gatgtactac atcggggcgg tactcgcgct catcgcactc      660

ctgctgcggc ttgagctccc tgagtctcct cgctggctgg ccgcgaaggg gcgagtcgaa      720

gaagccgccg ctgttgtagc tgctatggag gagcgcctgg gcttgggcgc gtttcaatcc      780

gatggaaccg ccgcatcgtt ctcgctggtc tccgacacga aagcgccgta tggcgaactg      840

tttggcagtc ctgtgtatcg caggcgaatc ttcctcctgt ttttcgtctg gctctttagc      900

tatgtgaccg tgtacggatt ttctgcaggc atgaccacgc tgctcgtggg cgcaggctat      960

gcgccgagtg aggcggggct catcgtggcc gtcggcgtct tgggcatgct gctggccggc     1020

gtcgtggcgt accttgcggg agaagtcatg gaacgcaaaa cctatctgct cgtgtctgcg     1080

gtcctgacca tcttgggagg actcgtggtg gggcttgctg gacaccatct gtggctttcg     1140

tacctcggtg caatcctcct cttcttcggg cagaacgtgt gggtgccggt gttttacgcg     1200

tggactgcgg aaaactttcc atctcgcgcg aggaccagcg gtttcgccct cgtggatgga     1260

gcgggacaca tcggcgccgg agtcggtttg tgggccatcg cgccgttgat tccctctctc     1320

ggcgtgaccg ccggatttgt ggcgatgtcg ggcttccttc tgatcgcggc gttcatcgcc     1380

cttggaggga ttgcgtctcg aggcaaagtt ttggaggaga tttcgccgta g              1431


<210>   781
<211>   1431
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   781
atgggcacgg gtgtgcctgt ttcgagcgcg gcgggcatct tggcgcggat ggagcggttg       60

accgcatggc cgcttccgcg gcgattgttc ctcgtcatcg gtctcgggta tctgttcacc      120

ttctacgaca tattcgacgt caatgtgtcc tttgtgcaga ccgccacatc catcataccc      180

ggtgcaactc cggcggacgc cagccggtac atcggattgc ccatcttcgc caacctgttg      240

gggtacgtgg tcggcacgct tgtgttgagc cctcttgccg atcgcgtcgg gcgaaggcgt      300

atgctgatga ccaccatgtt catcacgggg gtcggttctc tgttgacagc tctcgcgatg      360

cgcgactggt ggtttattct cgcgcgcggc atcacgggcg tgggcgtggc cgcggatctg      420

gctgtcgtga atacctacat gagcgaggtc gcgccgagaa gagcgagggc gaagtacacc      480

tcaggattgt tcattttctc aggtgtcgga gcgcttgtgg gcatctggct cgggttgtgg      540

ttgacgacgc ccagtgcgcc gtttccggaa ggacttccgt ttgcgcttgc aacttcgtcg      600

ttccattggg gctggcggtt gatgtactac atcggggcgg tactcgcgct catcgcactc      660

ctgctgcgga ttgagctccc tgagtctcct cgctggctgg ccgcgaaggg gcgagtcgaa      720

gaagccgccg ctgttgtagc tgctatggag gagcgcctgg gcttgggcgc gtttcaatcc      780

gatggaaccg ccgcatcgtt ctcgctggtc tccgacacgc gcgcgccgta tggcgaactg      840

tttggcagtc ctgtgtatcg caggcgaatc ttcctcctgt ttttcgtctg gctctttagc      900

tatgtgaccg tgtacggatt ttctgcaggc atgaccacgc tgctcgtggg cgcaggctat      960

gcgccgagtg aggcggggct catcgtggcc gtcggcgtct tgggcatgct gctggccggc     1020

gtcgtggcgt accttgcggg agaagtcatg gaacgcaaaa cctatctgct cgtgtctgcg     1080

gtcctgacca tcttgggagg actcgtggtg gggcttgctg gacaccatct gtggctttcg     1140

tacctcggtg caatcctcct cttcttcggg cagaacgtgt gggtgccggt gttttacgcg     1200

tggactgcgg aaaactttcc atctcgcgcg aggaccagcg gtttcgccct cgtggatgga     1260

gcgggacaca tcggcgccgg agtcggtttg tgggccatcg cgccgttgat tccctctctc     1320

ggcgtgaccg ccggatttgt ggcgatgtcg ggcttccttc tgatcgcggc gttcatcgcc     1380

cttggaggga ttgcgtctcg aggcaaagtt ttggaggaga tttcgccgta g              1431


<210>   782
<211>   1431
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 767

<400>   782
atgggcacgg gtgtgcctgt ttcgagcgcg gcgggcatct tggcgcggat ggagcggttg       60

accgcatggc cgcttccgcg gcgattgttc ctcgtcatcg gtctcgggta tctgttcacc      120

ttctacgaca tattcgacat taatgtgtcc tttgtgcaga ccgccacatc catcataccc      180

ggtgcaactc cggcggacgc cagccggtac atcggattgc ccatcttcgc caacctgttg      240

gggtacgtgg tcggcacgct tgtgttgagc cctcttgccg atcgcgtcgg gcgaaggcgt      300

atgctgatga ccaccatgtt catcacgggg gtcggttctc tgttgacagc tctcgcgatg      360

cgcgactggt ggtttattct cgcgcgcggc atcacgggcg tgggcgtggc cgcggatctg      420

gctgtcgtga atacctacat gagcgaggtc gcgccgagaa gagcgagggc gaagtacacc      480

tcaggattgt tcattttctc aggtgtcgga gcgcttgtgg gcatctggct cgggttgtgg      540

ttgacgacgc ccagtgcgcc gtttccggaa ggacttccgt ttgcgcttgc aacttcgtcg      600

ttccattggg gctggcggtt gatgtactac atcggggcgg tactcgcgct catcgcactc      660

ctgctgcggc ttgagctccc tgagtctcct cgctggctgg ccgcgaaggg gcgagtcgaa      720

gaagccgccg ctgttgtagc tgctatggag gagcgcctgg gcttgggcgc gtttcaatcc      780

gatggaaccg ccgcatcgtt ctcgctggtc tccgacacgc gcgcgccgta tggcgaactg      840

tttggcagtc ctgtgtatcg caggcgaatc ttcctcctgt ttttcgtctg gctctttagc      900

tatgtgaccg tgtacggatt ttctgcaggc atgaccacgc tgctcgtggg cgcaggctat      960

gcgccgagtg aggcggggct catcgtggcc gtcggcgtct tgggcatgct gctggccggc     1020

gtcgtggcgt accttgcggg agaagtcatg gaacgcaaaa cctatctgct cgtgtctgcg     1080

gtcctgacca tcttgggagg actcgtggtg gggcttgctg gacaccatct gtggctttcg     1140

tacctcggtg caatcctcct cttcttcggg cagaacgtgt gggtgccggt gttttacgcg     1200

tggactgcgg aaaactttcc atctcgcgcg aggaccagcg gtttcgccct cgtggatgga     1260

gcgggacaca tcggcgccgg agtcggtttg tgggccatcg cgccgttgat tccctctctc     1320

ggcgtgaccg ccggatttgt ggcgatgtcg ggcttccttc tgatcgcggc gttcatcgcc     1380

cttggaggga ttgcgtctcg aggcaaagtt ttggaggaga tttcgccgta g              1431
