                         SEQUENCE LISTING

<110>  Wyeth
       MedImmune Limited
 
<120>  INTERLEUKIN-21 RECEPTOR BINDING PROTEINS

<130>  01997.069000

<150>  US 61/055,500
<151>  2008-05-23

<160>  248   

<170>  PatentIn version 3.5

<210>  1
<211>  2665
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (236)..(1849)

<400>  1
gtcgactgga ggcccagctg cccgtcatca gagtgacagg tcttatgaca gcctgattgg       60

tgactcgggc tgggtgtgga ttctcacccc aggcctctgc ctgctttctc agaccctcat      120

ctgtcacccc cacgctgaac ccagctgcca cccccagaag cccatcagac tgcccccagc      180

acacggaatg gatttctgag aaagaagccg aaacagaagg cccgtgggag tcagc atg       238
                                                             Met          
                                                             1            

ccg cgt ggc tgg gcc gcc ccc ttg ctc ctg ctg ctg ctc cag gga ggc        286
Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly Gly           
            5                   10                  15                    

tgg ggc tgc ccc gac ctc gtc tgc tac acc gat tac ctc cag acg gtc        334
Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr Val           
        20                  25                  30                        

atc tgc atc ctg gaa atg tgg aac ctc cac ccc agc acg ctc acc ctt        382
Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr Leu           
    35                  40                  45                            

acc tgg caa gac cag tat gaa gag ctg aag gac gag gcc acc tcc tgc        430
Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser Cys           
50                  55                  60                  65            

agc ctc cac agg tcg gcc cac aat gcc acg cat gcc acc tac acc tgc        478
Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr Cys           
                70                  75                  80                

cac atg gat gta ttc cac ttc atg gcc gac gac att ttc agt gtc aac        526
His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val Asn           
            85                  90                  95                    

atc aca gac cag tct ggc aac tac tcc cag gag tgt ggc agc ttt ctc        574
Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe Leu           
        100                 105                 110                       

ctg gct gag agc atc aag ccg gct ccc cct ttc aac gtg act gtg acc        622
Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val Thr           
    115                 120                 125                           

ttc tca gga cag tat aat atc tcc tgg cgc tca gat tac gaa gac cct        670
Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp Pro           
130                 135                 140                 145           

gcc ttc tac atg ctg aag ggc aag ctt cag tat gag ctg cag tac agg        718
Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr Arg           
                150                 155                 160               

aac cgg gga gac ccc tgg gct gtg agt ccg agg aga aag ctg atc tca        766
Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile Ser           
            165                 170                 175                   

gtg gac tca aga agt gtc tcc ctc ctc ccc ctg gag ttc cgc aaa gac        814
Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys Asp           
        180                 185                 190                       

tcg agc tat gag ctg cag gtg cgg gca ggg ccc atg cct ggc tcc tcc        862
Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser Ser           
    195                 200                 205                           

tac cag ggg acc tgg agt gaa tgg agt gac ccg gtc atc ttt cag acc        910
Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln Thr           
210                 215                 220                 225           

cag tca gag gag tta aag gaa ggc tgg aac cct cac ctg ctg ctt ctc        958
Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu Leu           
                230                 235                 240               

ctc ctg ctt gtc ata gtc ttc att cct gcc ttc tgg agc ctg aag acc       1006
Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys Thr           
            245                 250                 255                   

cat cca ttg tgg agg cta tgg aag aag ata tgg gcc gtc ccc agc cct       1054
His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser Pro           
        260                 265                 270                       

gag cgg ttc ttc atg ccc ctg tac aag ggc tgc agc gga gac ttc aag       1102
Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe Lys           
    275                 280                 285                           

aaa tgg gtg ggt gca ccc ttc act ggc tcc agc ctg gag ctg gga ccc       1150
Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly Pro           
290                 295                 300                 305           

tgg agc cca gag gtg ccc tcc acc ctg gag gtg tac agc tgc cac cca       1198
Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His Pro           
                310                 315                 320               

cca cgg agc ccg gcc aag agg ctg cag ctc acg gag cta caa gaa cca       1246
Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro           
            325                 330                 335                   

gca gag ctg gtg gag tct gac ggt gtg ccc aag ccc agc ttc tgg ccg       1294
Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro           
        340                 345                 350                       

aca gcc cag aac tcg ggg ggc tca gct tac agt gag gag agg gat cgg       1342
Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg           
    355                 360                 365                           

cca tac ggc ctg gtg tcc att gac aca gtg act gtg cta gat gca gag       1390
Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu           
370                 375                 380                 385           

ggg cca tgc acc tgg ccc tgc agc tgt gag gat gac ggc tac cca gcc       1438
Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala           
                390                 395                 400               

ctg gac ctg gat gct ggc ctg gag ccc agc cca ggc cta gag gac cca       1486
Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro           
            405                 410                 415                   

ctc ttg gat gca ggg acc aca gtc ctg tcc tgt ggc tgt gtc tca gct       1534
Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala           
        420                 425                 430                       

ggc agc cct ggg cta gga ggg ccc ctg gga agc ctc ctg gac aga cta       1582
Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu           
    435                 440                 445                           

aag cca ccc ctt gca gat ggg gag gac tgg gct ggg gga ctg ccc tgg       1630
Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp           
450                 455                 460                 465           

ggt ggc cgg tca cct gga ggg gtc tca gag agt gag gcg ggc tca ccc       1678
Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro           
                470                 475                 480               

ctg gcc ggc ctg gat atg gac acg ttt gac agt ggc ttt gtg ggc tct       1726
Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser           
            485                 490                 495                   

gac tgc agc agc cct gtg gag tgt gac ttc acc agc ccc ggg gac gaa       1774
Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu           
        500                 505                 510                       

gga ccc ccc cgg agc tac ctc cgc cag tgg gtg gtc att cct ccg cca       1822
Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro           
    515                 520                 525                           

ctt tcg agc cct gga ccc cag gcc agc taatgaggct gactggatgt             1869
Leu Ser Ser Pro Gly Pro Gln Ala Ser                                       
530                 535                                                   

ccagagctgg ccaggccact gggccctgag ccagagacaa ggtcacctgg gctgtgatgt     1929

gaagacacct gcagcctttg gtctcctgga tgggcctttg agcctgatgt ttacagtgtc     1989

tgtgtgtgtg tgtgcatatg tgtgtgtgtg catatgcatg tgtgtgtgtg tgtgtgtctt     2049

aggtgcgcag tggcatgtcc acgtgtgtgt gtgattgcac gtgcctgtgg gcctgggata     2109

atgcccatgg tactccatgc attcacctgc cctgtgcatg tctggactca cggagctcac     2169

ccatgtgcac aagtgtgcac agtaaacgtg tttgtggtca acagatgaca acagccgtcc     2229

tccctcctag ggtcttgtgt tgcaagttgg tccacagcat ctccggggct ttgtgggatc     2289

agggcattgc ctgtgactga ggcggagccc agccctccag cgtctgcctc caggagctgc     2349

aagaagtcca tattgttcct tatcacctgc caacaggaag cgaaagggga tggagtgagc     2409

ccatggtgac ctcgggaatg gcaatttttt gggcggcccc tggacgaagg tctgaatccc     2469

gactctgata ccttctggct gtgctacctg agccaagtcg cctcccctct ctgggctaga     2529

gtttccttat ccagacagtg gggaaggcat gacacacctg ggggaaattg gcgatgtcac     2589

ccgtgtacgg tacgcagccc agagcagacc ctcaataaac gtcagcttcc ttcaaaaaaa     2649

aaaaaaaaaa tctaga                                                     2665


<210>  2
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  3
<211>  2628
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (407)..(1993)

<400>  3
gtcgacgcgg cggtaccagc tgtctgccca cttctcctgt ggtgtgcctc acggtcactt       60

gcttgtctga ccgcaagtct gcccatccct ggggcagcca actggcctca gcccgtgccc      120

caggcgtgcc ctgtctctgt ctggctgccc cagccctact gtcttcctct gtgtaggctc      180

tgcccagatg cccggctggt cctcagcctc aggactatct cagcagtgac tcccctgatt      240

ctggacttgc acctgactga actcctgccc acctcaaacc ttcacctccc accaccacca      300

ctccgagtcc cgctgtgact cccacgccca ggagaccacc caagtgcccc agcctaaaga      360

atggctttct gagaaagacc ctgaaggagt aggtctggga cacagc atg ccc cgg         415
                                                   Met Pro Arg            
                                                   1                      

ggc cca gtg gct gcc tta ctc ctg ctg att ctc cat gga gct tgg agc        463
Gly Pro Val Ala Ala Leu Leu Leu Leu Ile Leu His Gly Ala Trp Ser           
    5                   10                  15                            

tgc ctg gac ctc act tgc tac act gac tac ctc tgg acc atc acc tgt        511
Cys Leu Asp Leu Thr Cys Tyr Thr Asp Tyr Leu Trp Thr Ile Thr Cys           
20                  25                  30                  35            

gtc ctg gag aca cgg agc ccc aac ccc agc ata ctc agt ctc acc tgg        559
Val Leu Glu Thr Arg Ser Pro Asn Pro Ser Ile Leu Ser Leu Thr Trp           
                40                  45                  50                

caa gat gaa tat gag gaa ctt cag gac caa gag acc ttc tgc agc cta        607
Gln Asp Glu Tyr Glu Glu Leu Gln Asp Gln Glu Thr Phe Cys Ser Leu           
            55                  60                  65                    

cac agg tct ggc cac aac acc aca cat ata tgg tac acg tgc cat atg        655
His Arg Ser Gly His Asn Thr Thr His Ile Trp Tyr Thr Cys His Met           
        70                  75                  80                        

cgc ttg tct caa ttc ctg tcc gat gaa gtt ttc att gtc aat gtg acg        703
Arg Leu Ser Gln Phe Leu Ser Asp Glu Val Phe Ile Val Asn Val Thr           
    85                  90                  95                            

gac cag tct ggc aac aac tcc caa gag tgt ggc agc ttt gtc ctg gct        751
Asp Gln Ser Gly Asn Asn Ser Gln Glu Cys Gly Ser Phe Val Leu Ala           
100                 105                 110                 115           

gag agc atc aaa cca gct ccc ccc ttg aac gtg act gtg gcc ttc tca        799
Glu Ser Ile Lys Pro Ala Pro Pro Leu Asn Val Thr Val Ala Phe Ser           
                120                 125                 130               

gga cgc tat gat atc tcc tgg gac tca gct tat gac gaa ccc tcc aac        847
Gly Arg Tyr Asp Ile Ser Trp Asp Ser Ala Tyr Asp Glu Pro Ser Asn           
            135                 140                 145                   

tac gtg ctg agg ggc aag cta caa tat gag ctg cag tat cgg aac ctc        895
Tyr Val Leu Arg Gly Lys Leu Gln Tyr Glu Leu Gln Tyr Arg Asn Leu           
        150                 155                 160                       

aga gac ccc tat gct gtg agg ccg gtg acc aag ctg atc tca gtg gac        943
Arg Asp Pro Tyr Ala Val Arg Pro Val Thr Lys Leu Ile Ser Val Asp           
    165                 170                 175                           

tca aga aac gtc tct ctt ctc cct gaa gag ttc cac aaa gat tct agc        991
Ser Arg Asn Val Ser Leu Leu Pro Glu Glu Phe His Lys Asp Ser Ser           
180                 185                 190                 195           

tac cag ctg cag gtg cgg gca gcg cct cag cca ggc act tca ttc agg       1039
Tyr Gln Leu Gln Val Arg Ala Ala Pro Gln Pro Gly Thr Ser Phe Arg           
                200                 205                 210               

ggg acc tgg agt gag tgg agt gac ccc gtc atc ttt cag acc cag gct       1087
Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln Thr Gln Ala           
            215                 220                 225                   

ggg gag ccc gag gca ggc tgg gac cct cac atg ctg ctg ctc ctg gct       1135
Gly Glu Pro Glu Ala Gly Trp Asp Pro His Met Leu Leu Leu Leu Ala           
        230                 235                 240                       

gtc ttg atc att gtc ctg gtt ttc atg ggt ctg aag atc cac ctg cct       1183
Val Leu Ile Ile Val Leu Val Phe Met Gly Leu Lys Ile His Leu Pro           
    245                 250                 255                           

tgg agg cta tgg aaa aag ata tgg gca cca gtg ccc acc cct gag agt       1231
Trp Arg Leu Trp Lys Lys Ile Trp Ala Pro Val Pro Thr Pro Glu Ser           
260                 265                 270                 275           

ttc ttc cag ccc ctg tac agg gag cac agc ggg aac ttc aag aaa tgg       1279
Phe Phe Gln Pro Leu Tyr Arg Glu His Ser Gly Asn Phe Lys Lys Trp           
                280                 285                 290               

gtt aat acc cct ttc acg gcc tcc agc ata gag ttg gtg cca cag agt       1327
Val Asn Thr Pro Phe Thr Ala Ser Ser Ile Glu Leu Val Pro Gln Ser           
            295                 300                 305                   

tcc aca aca aca tca gcc tta cat ctg tca ttg tat cca gcc aag gag       1375
Ser Thr Thr Thr Ser Ala Leu His Leu Ser Leu Tyr Pro Ala Lys Glu           
        310                 315                 320                       

aag aag ttc ccg ggg ctg ccg ggt ctg gaa gag caa ctg gag tgt gat       1423
Lys Lys Phe Pro Gly Leu Pro Gly Leu Glu Glu Gln Leu Glu Cys Asp           
    325                 330                 335                           

gga atg tct gag cct ggt cac tgg tgc ata atc ccc ttg gca gct ggc       1471
Gly Met Ser Glu Pro Gly His Trp Cys Ile Ile Pro Leu Ala Ala Gly           
340                 345                 350                 355           

caa gcg gtc tca gcc tac agt gag gag aga gac cgg cca tat ggt ctg       1519
Gln Ala Val Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu           
                360                 365                 370               

gtg tcc att gac aca gtg act gtg gga gat gca gag ggc ctg tgt gtc       1567
Val Ser Ile Asp Thr Val Thr Val Gly Asp Ala Glu Gly Leu Cys Val           
            375                 380                 385                   

tgg ccc tgt agc tgt gag gat gat ggc tat cca gcc atg aac ctg gat       1615
Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Met Asn Leu Asp           
        390                 395                 400                       

gct ggc cga gag tct ggc cct aat tca gag gat ctg ctc ttg gtc aca       1663
Ala Gly Arg Glu Ser Gly Pro Asn Ser Glu Asp Leu Leu Leu Val Thr           
    405                 410                 415                           

gac cct gct ttt ctg tct tgc ggc tgt gtc tca ggt agt ggt ctc agg       1711
Asp Pro Ala Phe Leu Ser Cys Gly Cys Val Ser Gly Ser Gly Leu Arg           
420                 425                 430                 435           

ctt gga ggc tcc cca ggc agc cta ctg gac agg ttg agg ctg tca ttt       1759
Leu Gly Gly Ser Pro Gly Ser Leu Leu Asp Arg Leu Arg Leu Ser Phe           
                440                 445                 450               

gca aag gaa ggg gac tgg aca gca gac cca acc tgg aga act ggg tcc       1807
Ala Lys Glu Gly Asp Trp Thr Ala Asp Pro Thr Trp Arg Thr Gly Ser           
            455                 460                 465                   

cca gga ggg ggc tct gag agt gaa gca ggt tcc ccc cct ggt ctg gac       1855
Pro Gly Gly Gly Ser Glu Ser Glu Ala Gly Ser Pro Pro Gly Leu Asp           
        470                 475                 480                       

atg gac aca ttt gac agt ggc ttt gca ggt tca gac tgt ggc agc ccc       1903
Met Asp Thr Phe Asp Ser Gly Phe Ala Gly Ser Asp Cys Gly Ser Pro           
    485                 490                 495                           

gtg gag act gat gaa gga ccc cct cga agc tat ctc cgc cag tgg gtg       1951
Val Glu Thr Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val           
500                 505                 510                 515           

gtc agg acc cct cca cct gtg gac agt gga gcc cag agc agc               1993
Val Arg Thr Pro Pro Pro Val Asp Ser Gly Ala Gln Ser Ser                   
                520                 525                                   

tagcatataa taaccagcta tagtgagaag aggcctctga gcctggcatt tacagtgtga     2053

acatgtaggg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     2113

gtgtgtgtgt cttgggttgt gtgttagcac atccatgttg ggatttggtc tgttgctatg     2173

tattgtaatg ctaaattctc tacccaaagt tctaggccta cgagtgaatt ctcatgttta     2233

caaacttgct gtgtaaacct tgttccttaa tttaatacca ttggttaaat aaaattggct     2293

gcaaccaatt actggaggga ttagaggtag ggggcttttg agttacctgt ttggagatgg     2353

agaaggagag aggagagacc aagaggagaa ggaggaagga gaggagagga gaggagagga     2413

gaggagagga gaggagagga gaggagagga gaggagaggc tgccgtgagg ggagagggac     2473

catgagcctg tggccaggag aaacagcaag tatctggggt acactggtga ggaggtggcc     2533

aggccagcag ttagaagagt agattagggg tgacctccag tatttgtcaa agccaattaa     2593

aataacaaaa aaaaaaaaaa agcggccgct ctaga                                2628


<210>  4
<211>  529
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Arg Gly Pro Val Ala Ala Leu Leu Leu Leu Ile Leu His Gly 
1               5                   10                  15      


Ala Trp Ser Cys Leu Asp Leu Thr Cys Tyr Thr Asp Tyr Leu Trp Thr 
            20                  25                  30          


Ile Thr Cys Val Leu Glu Thr Arg Ser Pro Asn Pro Ser Ile Leu Ser 
        35                  40                  45              


Leu Thr Trp Gln Asp Glu Tyr Glu Glu Leu Gln Asp Gln Glu Thr Phe 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Gly His Asn Thr Thr His Ile Trp Tyr Thr 
65                  70                  75                  80  


Cys His Met Arg Leu Ser Gln Phe Leu Ser Asp Glu Val Phe Ile Val 
                85                  90                  95      


Asn Val Thr Asp Gln Ser Gly Asn Asn Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Val Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Leu Asn Val Thr Val 
        115                 120                 125             


Ala Phe Ser Gly Arg Tyr Asp Ile Ser Trp Asp Ser Ala Tyr Asp Glu 
    130                 135                 140                 


Pro Ser Asn Tyr Val Leu Arg Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Leu Arg Asp Pro Tyr Ala Val Arg Pro Val Thr Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Asn Val Ser Leu Leu Pro Glu Glu Phe His Lys 
            180                 185                 190         


Asp Ser Ser Tyr Gln Leu Gln Val Arg Ala Ala Pro Gln Pro Gly Thr 
        195                 200                 205             


Ser Phe Arg Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ala Gly Glu Pro Glu Ala Gly Trp Asp Pro His Met Leu Leu 
225                 230                 235                 240 


Leu Leu Ala Val Leu Ile Ile Val Leu Val Phe Met Gly Leu Lys Ile 
                245                 250                 255     


His Leu Pro Trp Arg Leu Trp Lys Lys Ile Trp Ala Pro Val Pro Thr 
            260                 265                 270         


Pro Glu Ser Phe Phe Gln Pro Leu Tyr Arg Glu His Ser Gly Asn Phe 
        275                 280                 285             


Lys Lys Trp Val Asn Thr Pro Phe Thr Ala Ser Ser Ile Glu Leu Val 
    290                 295                 300                 


Pro Gln Ser Ser Thr Thr Thr Ser Ala Leu His Leu Ser Leu Tyr Pro 
305                 310                 315                 320 


Ala Lys Glu Lys Lys Phe Pro Gly Leu Pro Gly Leu Glu Glu Gln Leu 
                325                 330                 335     


Glu Cys Asp Gly Met Ser Glu Pro Gly His Trp Cys Ile Ile Pro Leu 
            340                 345                 350         


Ala Ala Gly Gln Ala Val Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro 
        355                 360                 365             


Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Gly Asp Ala Glu Gly 
    370                 375                 380                 


Leu Cys Val Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Met 
385                 390                 395                 400 


Asn Leu Asp Ala Gly Arg Glu Ser Gly Pro Asn Ser Glu Asp Leu Leu 
                405                 410                 415     


Leu Val Thr Asp Pro Ala Phe Leu Ser Cys Gly Cys Val Ser Gly Ser 
            420                 425                 430         


Gly Leu Arg Leu Gly Gly Ser Pro Gly Ser Leu Leu Asp Arg Leu Arg 
        435                 440                 445             


Leu Ser Phe Ala Lys Glu Gly Asp Trp Thr Ala Asp Pro Thr Trp Arg 
    450                 455                 460                 


Thr Gly Ser Pro Gly Gly Gly Ser Glu Ser Glu Ala Gly Ser Pro Pro 
465                 470                 475                 480 


Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Ala Gly Ser Asp Cys 
                485                 490                 495     


Gly Ser Pro Val Glu Thr Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg 
            500                 505                 510         


Gln Trp Val Val Arg Thr Pro Pro Pro Val Asp Ser Gly Ala Gln Ser 
        515                 520                 525             


Ser 
    


<210>  5
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  5
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagt            354


<210>  6
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  7
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  7
caggtgcagc tgcaggagtc tggccctggc ctggtgaagc cttccgagac cctgtctctg       60

acctgtgccg tgtccggcta ctccatctcc tccggctact actggggctg gatcagacag      120

cctcctggca agggcctgga gtggatcggc tccatctctc acaccggcaa cacctactac      180

aacccccctc tgaagtccag agtgaccatc tccgtggaca cctccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgctgccgat accgccgtgt actactgtgc cagaggcggc      300

ggaatctcca gacctgagta ctggggccag ggcaccctgg tgaccgtgtc ctct            354


<210>  8
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  9
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  9
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg taactcccgg gactccagtg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  10
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  11
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  11
tcctctgagc tgacccagga tcctgctgtg tctgtggccc tgggccagac cgtcaggatc       60

acctgccagg gcgatagcct gagaacctac tacgcctcct ggtatcagca gaagcctgga      120

caggcccctg tgctggtgat ctacggcaag cacaagaggc catccggcat ccctgacaga      180

ttctccggct cctcctctgg caataccgcc tccctgacca tcaccggcgc tcaggccgag      240

gacgaggccg actactactg taactcccgg gactcttccg gcaaccctca cgtgctgttt      300

ggcggcggaa cccagctgac cgtgcta                                          327


<210>  12
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  13
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  H3 VH

<400>  13
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgattcatg      300

gggttcggcc gcccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagt            354


<210>  14
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  H3 VH

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  15
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  H4 VH

<400>  15
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgatggctc      300

gggttcggcc gcccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagt            354


<210>  16
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  H4 VH

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Leu Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  17
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  H5 VH

<400>  17
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgattcttg      300

ggcttcggcc ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagt            354


<210>  18
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  H5 VH

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Leu Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  H6 VH

<400>  19
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgattcttc      300

ggcttcggcc gcccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagt            354


<210>  20
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  H6 VH

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Phe Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  21
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L1 VL

<400>  21
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgcgtcccgg tcggtgagcg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  22
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L1 VL

<400>  22

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Arg Ser Val Ser Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  23
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L2 VL

<400>  23
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtcgcccgg tcggtggtgg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  24
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L2 VL

<400>  24

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Val Val Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  25
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L3 VL

<400>  25
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtcagcagg gcggtggtgg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  26
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L3 VL

<400>  26

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ser Arg Ala Val Val Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  27
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  L4 VL

<400>  27
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tagcacccgc agcagcaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  28
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L4 VL

<400>  28

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Arg Ser Ser Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  29
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L5 VL

<400>  29
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgccagcagg tcctccaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  30
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L5 VL

<400>  30

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Arg Ser Ser Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  31
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L6 VL

<400>  31
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tatgagcagg agcatctggg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  32
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L6 VL

<400>  32

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Met Ser Arg Ser Ile Trp Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  33
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L8 VL

<400>  33
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg taccacgcgc tccacccagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  34
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L8 VL

<400>  34

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Arg Ser Thr Gln Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  35
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L9 VL

<400>  35
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtcgccagg tccaacaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  36
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L9 VL

<400>  36

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Asn Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  37
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L10 VL

<400>  37
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tatcagccgg tcgatctacg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  38
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L10 VL

<400>  38

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ile Ser Arg Ser Ile Tyr Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  39
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L11 VL

<400>  39
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg ttcctcccgc tcccgccacg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  40
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L11 VL

<400>  40

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Ser Arg His Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  41
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L12 VL

<400>  41
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtcgcgagg gggacgaggg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  42
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L12 VL

<400>  42

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Gly Thr Arg Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  43
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L13 VL

<400>  43
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtcacccgc aaccgctacg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  44
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L13 VL

<400>  44

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Asn Arg Tyr Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  45
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L14 VL

<400>  45
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tatggcgagg tcgaggaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  46
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L14 VL

<400>  46

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Met Ala Arg Ser Arg Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  47
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L15 VL

<400>  47
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg ttccacccgc gccatccacg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  48
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L15 VL

<400>  48

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Arg Ala Ile His Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  49
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L16 VL

<400>  49
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtgacgagg agcgcgaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  50
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L16 VL

<400>  50

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Ala Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  51
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L17 VL

<400>  51
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tagcacgagg tcgaggaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  52
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L17 VL

<400>  52

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Arg Ser Arg Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  53
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L18 VL

<400>  53
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtcacgagg agcgtgaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  54
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L18 VL

<400>  54

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Val Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  55
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L19 VL

<400>  55
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtcgcgcgg gcggtgaggg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  56
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L19 VL

<400>  56

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ala Val Arg Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  57
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L20 VL

<400>  57
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgtctcccgc agcgcgaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  58
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L20 VL

<400>  58

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ser Arg Ser Ala Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  59
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L21 VL

<400>  59
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tgccacccgg gcggtccggg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  60
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L21 VL

<400>  60

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Arg Ala Val Arg Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  61
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L23 VL

<400>  61
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg ttcggcgcgg tcggtgaggg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  62
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L23 VL

<400>  62

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Arg Ser Val Arg Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  63
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L24 VL

<400>  63
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tatcgccagg agcaacaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  64
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L24 VL

<400>  64

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ile Ala Arg Ser Asn Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  65
<211>  327
<212>  DNA
<213>  artificial

<220>
<223>  L25 VL

<400>  65
tcttctgagc tgactcagga ccctcctgtg tctgtggcct tgggacagac agtcacgctc       60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagtcagga      120

caggccccta tacttctcct ctatggtaaa cacaaacggc cctcagggat cccagaccgc      180

ttctctggct ccacctcagg agacacagct tccttgacca tcactggggc tcaggcggaa      240

gacgaggctg actattactg tacgacgcgg agcaacaagg gcaaccccca tgttctgttc      300

ggcggaggga cccagctcac cgtttta                                          327


<210>  66
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  L25 VL

<400>  66

Ser Ser Glu Leu Thr Gln Asp Pro Pro Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Ile Leu Leu Leu Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Arg Ser Asn Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  67
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VH4 heavy chain

<400>  67
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag atggctcggg      360

ttcggccgcc cggagtactg gggcaaaggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  68
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VH4 heavy chain

<400>  68

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Leu Gly Phe Gly Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  69
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VH5 heavy chain

<400>  69
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag attcttgggc      360

ttcggccggc cggagtactg gggcaaaggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  70
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VH5 heavy chain

<400>  70

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Phe Leu Gly Phe Gly Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  71
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VH6 heavy chain

<400>  71
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag attcttcggc      360

ttcggccgcc cggagtactg gggcaaaggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  72
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VH6 heavy chain

<400>  72

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Phe Phe Gly Phe Gly Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  73
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL3 light chain

<400>  73
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt cagcagggcg gtggtgggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  74
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL3 light chain

<400>  74

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ser Arg Ala Val Val 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  75
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL11 light chain

<400>  75
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgttc ctcccgctcc cgccacggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  76
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL11 light chain

<400>  76

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Ser Arg His 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  77
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL13 light chain

<400>  77
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt cacccgcaac cgctacggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  78
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL13 light chain

<400>  78

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Asn Arg Tyr 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  79
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL14 light chain

<400>  79
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtat ggcgaggtcg aggaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  80
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL14 light chain

<400>  80

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ala Arg Ser Arg Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  81
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL17 light chain

<400>  81
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccag aatcctgacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtag cacgaggtcg aggaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  82
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL17 light chain

<400>  82

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Arg Ile Leu Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Arg Ser Arg Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  83
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL23 light chain

<400>  83
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgttc ggcgcggtcg gtgaggggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  84
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL23 light chain

<400>  84

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Arg Ser Val Arg 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  85
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL24 light chain

<400>  85
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtat cgccaggagc aacaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  86
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL24 light chain

<400>  86

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ile Ala Arg Ser Asn Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  87
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VHPTM heavy chain with signal sequence

<400>  87
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag aggcggcgga      360

atctccagac ctgagtactg gggccagggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  88
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VHPTM heavy chain with signal sequence

<400>  88

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  89
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VHPDM heavy chain with signal sequence

<400>  89
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag aggcggcgga      360

atctccagac ctgagtactg gggccagggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccctgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  90
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VHPDM heavy chain with signal sequence

<400>  90

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  91
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VH3TM heavy chain with signal sequence

<400>  91
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag attcatgggg      360

ttcggccgcc cggagtactg gggccagggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  92
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VH3DM heavy chain with signal sequence

<400>  92

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  93
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VH3DM heavy chain with signal sequence

<400>  93
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag attcatgggg      360

ttcggccgcc cggagtactg gggccagggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccctgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  94
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VH3TM heavy chain with signal sequence

<400>  94

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  95
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL2 light chain with signal sequence

<400>  95
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt cgcccggtcg gtggtgggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  96
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL2 light chain with signal sequence

<400>  96

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Val Val 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  97
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL6 light chain with signal sequence

<400>  97
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtat gagcaggagc atctggggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  98
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL6 light chain with signal sequence

<400>  98

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ser Arg Ser Ile Trp 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  99
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL9 light chain with signal sequence

<400>  99
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt cgccaggtcc aacaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  100
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL9 light chain with signal sequence

<400>  100

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Asn Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  101
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL16 light chain  with signal sequence

<400>  101
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt gacgaggagc gcgaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  102
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL16 light chain with signal sequence

<400>  102

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Ala Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  103
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL18 light chain with signal sequence

<400>  103
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt cacgaggagc gtgaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  104
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL18 light chain with signal sequence

<400>  104

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Val Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  105
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL20 light chain with signal sequence

<400>  105
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt ctcccgcagc gcgaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  106
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL20 light chain with signal sequence

<400>  106

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ser Arg Ser Ala Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  107
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  VL25 light chain with signal sequence

<400>  107
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtac gacgcggagc aacaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  108
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL25 light chain with signal sequence

<400>  108

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Arg Ser Asn Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  109
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  H3 scFV

<400>  109
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgattcatg      300

gggttcggcc gcccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtaact cccgggactc cagtggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  110
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  H3 scFV

<400>  110

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
    210                 215                 220                 


Arg Asp Ser Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  111
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  H4 scFV

<400>  111
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgatggctc      300

gggttcggcc gcccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtaact cccgggactc cagtggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  112
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  H4 scFV

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Leu Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
    210                 215                 220                 


Arg Asp Ser Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  113
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  H5 scFV

<400>  113
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgattcttg      300

ggcttcggcc ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtaact cccgggactc cagtggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  114
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  H5 scFV

<400>  114

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Leu Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
    210                 215                 220                 


Arg Asp Ser Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  115
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  H6 scFv

<400>  115
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgattcttc      300

ggcttcggcc gcccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtaact cccgggactc cagtggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  116
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  H6 scFv

<400>  116

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Phe Gly Phe Gly Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
    210                 215                 220                 


Arg Asp Ser Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  117
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L1 scFv

<400>  117
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgcgt cccggtcggt gagcggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  118
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L1 scFv

<400>  118

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
    210                 215                 220                 


Arg Ser Val Ser Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  119
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L2 scFv

<400>  119
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtcg cccggtcggt ggtgggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  120
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L2 scFv

<400>  120

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala 
    210                 215                 220                 


Arg Ser Val Val Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  121
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L3 scFV

<400>  121
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtca gcagggcggt ggtgggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  122
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L3 scFv

<400>  122

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ser 
    210                 215                 220                 


Arg Ala Val Val Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  123
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L4 scFv

<400>  123
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtagca cccgcagcag caagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  124
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L4 scFv

<400>  124

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr 
    210                 215                 220                 


Arg Ser Ser Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  125
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L5 scFv

<400>  125
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgcca gcaggtcctc caagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  126
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L5 scFv

<400>  126

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
    210                 215                 220                 


Arg Ser Ser Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  127
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L6 scFv

<400>  127
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtatga gcaggagcat ctggggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  128
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L6 scFv

<400>  128

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ser 
    210                 215                 220                 


Arg Ser Ile Trp Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  129
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L8 scFv

<400>  129
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtacca cgcgctccac ccagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  130
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L8 scFv

<400>  130

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Thr 
    210                 215                 220                 


Arg Ser Thr Gln Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  131
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L9 scFv

<400>  131
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtcg ccaggtccaa caagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  132
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L9 scFv

<400>  132

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala 
    210                 215                 220                 


Arg Ser Asn Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  133
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L10 scFv

<400>  133
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtatca gccggtcgat ctacggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  134
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L10 scFv

<400>  134

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ile Ser 
    210                 215                 220                 


Arg Ser Ile Tyr Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  135
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L11 scFv

<400>  135
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgttcct cccgctcccg ccacggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  136
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L11 scFv

<400>  136

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
    210                 215                 220                 


Arg Ser Arg His Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  137
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L12 scFv

<400>  137
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtcg cgagggggac gaggggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  138
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L12 scFv

<400>  138

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala 
    210                 215                 220                 


Arg Gly Thr Arg Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  139
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L13 scFv

<400>  139
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtca cccgcaaccg ctacggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  140
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L13 scFv

<400>  140

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr 
    210                 215                 220                 


Arg Asn Arg Tyr Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  141
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L14 scFv

<400>  141
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtatgg cgaggtcgag gaagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  142
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L14 scFv

<400>  142

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ala 
    210                 215                 220                 


Arg Ser Arg Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  143
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L15 scFv

<400>  143
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgttcca cccgcgccat ccacggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  144
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L15 scFv

<400>  144

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr 
    210                 215                 220                 


Arg Ala Ile His Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  145
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L16 scFv

<400>  145
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtga cgaggagcgc gaagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  146
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L16 scFv

<400>  146

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr 
    210                 215                 220                 


Arg Ser Ala Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  147
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L17 scFv

<400>  147
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtagca cgaggtcgag gaagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  148
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L17 scFv

<400>  148

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr 
    210                 215                 220                 


Arg Ser Arg Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  149
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L18 scFv

<400>  149
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtca cgaggagcgt gaagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  150
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L18 scFv

<400>  150

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr 
    210                 215                 220                 


Arg Ser Val Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  151
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L19 scFv

<400>  151
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtcg cgcgggcggt gaggggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  152
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L19 scFv

<400>  152

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala 
    210                 215                 220                 


Arg Ala Val Arg Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  153
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L20 scFv

<400>  153
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgtct cccgcagcgc gaagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  154
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L20 scFv

<400>  154

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ser 
    210                 215                 220                 


Arg Ser Ala Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  155
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L21 scFv

<400>  155
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtgcca cccgggcggt ccggggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  156
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L21 scFv

<400>  156

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr 
    210                 215                 220                 


Arg Ala Val Arg Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  157
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L23 scFv

<400>  157
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgttcgg cgcggtcggt gaggggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  158
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L23 scFv

<400>  158

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala 
    210                 215                 220                 


Arg Ser Val Arg Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  159
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L24 scFv

<400>  159
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtatcg ccaggagcaa caagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  160
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L24 scFv

<400>  160

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ile Ala 
    210                 215                 220                 


Arg Ser Asn Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  161
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  L25 scFv

<400>  161
caggtgcagc tgcaggagtc gggcccagga ctggtgaaga cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggttgga gtggattggg agtatctctc atactgggaa cacctactac      180

aacccgcccc tcaagagtcg cgtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaaactga gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg      300

ggaattagca ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttcttc tgagctgact      420

caggaccctc ctgtgtctgt ggccttggga cagacagtca cgctcacatg ccaaggagac      480

agcctcagaa cctattatgc aagctggtac cagcagaagt caggacaggc ccctatactt      540

ctcctctatg gtaaacacaa acggccctca gggatcccag accgcttctc tggctccacc      600

tcaggagaca cagcttcctt gaccatcact ggggctcagg cggaagacga ggctgactat      660

tactgtacga cgcggagcaa caagggcaac ccccatgttc tgttcggcgg agggacccag      720

ctcaccgttt ta                                                          732


<210>  162
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  L25 scFv

<400>  162

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Thr Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Pro 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Thr Leu Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Thr Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Ser Gly Gln 
                165                 170                 175     


Ala Pro Ile Leu Leu Leu Tyr Gly Lys His Lys Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asp Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Thr 
    210                 215                 220                 


Arg Ser Asn Lys Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  163
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  163

Ser Gly Tyr Tyr Trp Gly 
1               5       


<210>  164
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  164

Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu Lys Ser 
1               5                   10                  15      


<210>  165
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  H3 heavy chain CDR3

<400>  165

Phe Met Gly Phe Gly Arg Pro Glu Tyr 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  H4 heavy chain CDR3

<400>  166

Trp Leu Gly Phe Gly Arg Pro Glu Tyr 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  H5 heavy chain CDR3

<400>  167

Phe Leu Gly Phe Gly Arg Pro Glu Tyr 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  H6 heavy chain CDR3

<400>  168

Phe Phe Gly Phe Gly Arg Pro Glu Tyr 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  169

Gly Gly Gly Ile Ser Arg Pro Glu Tyr 
1               5                   


<210>  170
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  170

Asn Ser Arg Asp Ser Ser Gly Asn Pro His Val Leu 
1               5                   10          


<210>  171
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L1 light chain CDR3

<400>  171

Ala Ser Arg Ser Val Ser Gly Asn Pro His Val Leu 
1               5                   10          


<210>  172
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L2 light chain CDR3

<400>  172

Val Ala Arg Ser Val Val Gly Asn Pro His Val Leu 
1               5                   10          


<210>  173
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L3 light chain CDR3

<400>  173

Val Ser Arg Ala Val Val Gly Asn Pro His Val Leu 
1               5                   10          


<210>  174
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L4 light chain CDR3

<400>  174

Ser Thr Arg Ser Ser Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  175
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L5 light chain CDR3

<400>  175

Ala Ser Arg Ser Ser Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  176
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L6 light chain CDR3

<400>  176

Met Ser Arg Ser Ile Trp Gly Asn Pro His Val Leu 
1               5                   10          


<210>  177
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L8 light chain CDR3

<400>  177

Thr Thr Arg Ser Thr Gln Gly Asn Pro His Val Leu 
1               5                   10          


<210>  178
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L9 light chain CDR3

<400>  178

Val Ala Arg Ser Asn Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  179
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L10 light chain CDR3

<400>  179

Ile Ser Arg Ser Ile Tyr Gly Asn Pro His Val Leu 
1               5                   10          


<210>  180
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L11 light chain CDR3

<400>  180

Ser Ser Arg Ser Arg His Gly Asn Pro His Val Leu 
1               5                   10          


<210>  181
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L12 light chain CDR3

<400>  181

Val Ala Arg Gly Thr Arg Gly Asn Pro His Val Leu 
1               5                   10          


<210>  182
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L13 light chain CDR3

<400>  182

Val Thr Arg Asn Arg Tyr Gly Asn Pro His Val Leu 
1               5                   10          


<210>  183
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L14 light chain CDR3

<400>  183

Met Ala Arg Ser Arg Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  184
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L15 light chain CDR3

<400>  184

Ser Thr Arg Ala Ile His Gly Asn Pro His Val Leu 
1               5                   10          


<210>  185
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L16 light chain CDR3

<400>  185

Val Thr Arg Ser Ala Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  186
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L17 light chain CDR3

<400>  186

Ser Thr Arg Ser Arg Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  187
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L18 light chain CDR3

<400>  187

Val Thr Arg Ser Val Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  188
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L19 light chain CDR3

<400>  188

Val Ala Arg Ala Val Arg Gly Asn Pro His Val Leu 
1               5                   10          


<210>  189
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L20 light chain CDR3

<400>  189

Val Ser Arg Ser Ala Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  190
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L21 light chain CDR3

<400>  190

Ala Thr Arg Ala Val Arg Gly Asn Pro His Val Leu 
1               5                   10          


<210>  191
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L23 light chain CDR3

<400>  191

Ser Ala Arg Ser Val Arg Gly Asn Pro His Val Leu 
1               5                   10          


<210>  192
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L24 light chain CDR3

<400>  192

Ile Ala Arg Ser Asn Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  193
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  L25 light chain CDR3

<400>  193

Thr Thr Arg Ser Asn Lys Gly Asn Pro His Val Leu 
1               5                   10          


<210>  194
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  194

Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala Ser 
1               5                   10      


<210>  195
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  195

Gly Lys His Lys Arg Pro Ser 
1               5           


<210>  196
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  human IgG constant region TM

<400>  196

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  197
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  human IgG constant region DM

<400>  197

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  198
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  198

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  199
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  199
gctctgtgac cgccgcagac acggccgtgt attactgtgc gcgaggtggg ggaattagca       60

ggccggagta ctggggcaaa ggcaccctgg tcaccgtctc                            100


<210>  200
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  200

Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
1               5                   10                  15      


Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly Thr Leu Val Thr 
            20                  25                  30          


Val Ser 
        


<210>  201
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  H3B1 VH library


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is a, c, g, or t

<400>  201
cacataatga cacgcgctnn snnsnnsnns nnsnnsggcc tcatgacccc gtttccgtgg       60


<210>  202
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  H3B1 VH library

<400>  202

Val Tyr Tyr Cys Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp 
1               5                   10                  15      


Gly Lys Gly Thr 
            20  


<210>  203
<211>  56
<212>  DNA
<213>  artificial

<220>
<223>  H3B2 VH library


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<400>  203
gacacgcgct ccaccccctn nsnnsnnsnn snnsnnsacc ccgtttccgt gggacc           56


<210>  204
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  H3B2 VH library

<400>  204

Cys Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Lys Gly 
1               5                   10                  15      


Thr Leu 
        


<210>  205
<211>  85
<212>  DNA
<213>  Homo sapiens

<400>  205
ggctgactat tactgtaact cccgggactc cagtggcaac ccccatgttc tgttcggcgg       60

agggacccag ctcaccgttt taagt                                             85


<210>  206
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  206

Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro His Val 
1               5                   10                  15      


Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser 
            20                  25              


<210>  207
<211>  55
<212>  DNA
<213>  artificial

<220>
<223>  L3B1 VL library


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<400>  207
ccgactgata atgacannsn nsnnsnnsnn snnsccgttg ggggtacaag acaag            55


<210>  208
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  L3B1 VL library

<400>  208

Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro His Val 
1               5                   10                  15      


Leu Phe 
        


<210>  209
<211>  59
<212>  DNA
<213>  artificial

<220>
<223>  L3B2 VL library


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<400>  209
gacattgagg gccctgaggt cannsnnsnn snnsnnsnns aagccgcctc cctgggtcg        59


<210>  210
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  L3B2 VL library

<400>  210

Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro His Val Leu Phe Gly Gly 
1               5                   10                  15      


Gly Thr Gln 
            


<210>  211
<211>  617
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (47)..(532)

<400>  211
gctgaagtga aaacgagacc aaggtctagc tctactgttg gtactt atg aga tcc          55
                                                   Met Arg Ser            
                                                   1                      

agt cct ggc aac atg gag agg att gtc atc tgt ctg atg gtc atc ttc        103
Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met Val Ile Phe           
    5                   10                  15                            

ttg ggg aca ctg gtc cac aaa tca agc tcc caa ggt caa gat cgc cac        151
Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln Asp Arg His           
20                  25                  30                  35            

atg att aga atg cgt caa ctt ata gat att gtt gat cag ctg aaa aat        199
Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn           
                40                  45                  50                

tat gtg aat gac ttg gtc cct gaa ttt ctg cca gct cca gaa gat gta        247
Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val           
            55                  60                  65                    

gag aca aac tgt gag tgg tca gct ttt tcc tgc ttt cag aag gcc caa        295
Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln           
        70                  75                  80                        

cta aag tca gca aat aca gga aac aat gaa agg ata atc aat gta tca        343
Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser           
    85                  90                  95                            

att aaa aag ctg aag agg aaa cca cct tcc aca aat gca ggg aga aga        391
Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg           
100                 105                 110                 115           

cag aaa cac aga cta aca tgc cct tca tgt gat tct tat gag aaa aaa        439
Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys           
                120                 125                 130               

cca ccc aaa gaa ttc cta gaa aga ttc aaa tca ctt ctc caa aag atg        487
Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met           
            135                 140                 145                   

att cat cag cat ctg tcc tct aga aca cac gga agt gaa gat tcc            532
Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser               
        150                 155                 160                       

tgaggatcta acttgcagtt ggacactatg ttacatactc taatatagta gtgaaagtca      592

tttctttgta ttccaagtgg aggag                                            617


<210>  212
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210>  213
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  VH3DM heavy chain

<400>  213

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  214
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  VL2 light chain

<400>  214

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Val Val Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  215
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  variable region of VL2 light chain

<400>  215

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Val Val Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  216
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  VL18 light chain

<400>  216

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Val Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  217
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  variable region of VL18 light chain

<400>  217

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Val Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  218
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  VH3TM heavy chain

<400>  218

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  219
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  VHPTM heavy chain

<400>  219

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn Pro Pro Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  220
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  VL6 light chain

<400>  220

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Met Ser Arg Ser Ile Trp Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  221
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  variable region of VL6 light chain

<400>  221

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Met Ser Arg Ser Ile Trp Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  222
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  VL9 light chain

<400>  222

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Asn Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  223
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  variable region of VL9 light chain

<400>  223

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Asn Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  224
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  VL16 light chain

<400>  224

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Ala Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  225
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  variable region of VL16 light chain

<400>  225

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Ala Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  226
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  VL20 light chain

<400>  226

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ser Arg Ser Ala Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  227
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  variable region of VL20 light chain

<400>  227

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Val Ser Arg Ser Ala Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  228
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  VL25 light chain

<400>  228

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Arg Ser Asn Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  229
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  variable region of VL25 light chain

<400>  229

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Arg Ser Asn Lys Gly Asn Pro 
                85                  90                  95      


His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  230
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer BssHII_II_VH_F

<400>  230
gcttggcgcg cactctcagg tgcagctgca ggag                                   34


<210>  231
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer GVH_R_for_BssHII

<400>  231
tcagggagaa ctggttcttg g                                                 21


<210>  232
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer G_VH_F_for_SalI

<400>  232
tccaagaacc agttctccct g                                                 21


<210>  233
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer scFv_SalI_VH_R

<400>  233
gcgacgtcga caggactcac cactcgagac ggtgaccagg gtgcc                       45


<210>  234
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Sal_VH_R_RJ

<400>  234
gcgacgtcga caggactcac cactcgagac gg                                     32


<210>  235
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer BssHII_II_VL_F

<400>  235
gcttggcgcg cactcttcct ctgagctgac ccag                                   34


<210>  236
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer scFv_VL_R_for_BssHII

<400>  236
gcctgagccc cagtgatggt ca                                                22


<210>  237
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer GVL_F_for_XbaI

<400>  237
accgcctccc tgaccatcac                                                   20


<210>  238
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer scFv_XbaI_VL_R

<400>  238
gcgccgtcta gagttattct actcacctaa aacggtgagc tgggtccctc                  50


<210>  239
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VHPTM heavy chain with signal sequence

<400>  239
atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag aggcggcgga      360

atctccagac ctgagtactg gggccagggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  240
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VHPTM heavy chain with signal sequence

<400>  240

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Gly Ile Ser Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  241
<211>  1401
<212>  DNA
<213>  artificial

<220>
<223>  VH3TM heavy chain with signal sequence

<400>  241
atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt gcactctcag       60

gtgcagctgc aggagtctgg ccctggcctg gtgaagcctt ccgagaccct gtctctgacc      120

tgtgccgtgt ccggctactc catctcctcc ggctactact ggggctggat cagacagcct      180

cctggcaagg gcctggagtg gatcggctcc atctctcaca ccggcaacac ctactacaac      240

ccccctctga agtccagagt gaccatctcc gtggacacct ccaagaacca gttctccctg      300

aagctgtcct ctgtgaccgc tgccgatacc gccgtgtact actgtgccag attcatgggg      360

ttcggccgcc cggagtactg gggccagggc accctggtga ccgtgtcctc tgcctccacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggc accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

ggtcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa a                                               1401


<210>  242
<211>  467
<212>  PRT
<213>  artificial

<220>
<223>  VH3TM heavy chain with signal sequence

<400>  242

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Ser His Thr Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Pro Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Phe Met Gly Phe Gly Arg Pro Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  243
<211>  703
<212>  DNA
<213>  artificial

<220>
<223>  VL2 light chain with signal sequence

<400>  243
atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt cgcccggtcg gtggtgggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt cat                        703


<210>  244
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL2 light chain with signal sequence

<400>  244

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala Arg Ser Val Val 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  245
<211>  703
<212>  DNA
<213>  artificial

<220>
<223>  VL18 light chain with signal sequence

<400>  245
atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtgt cacgaggagc gtgaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt cat                        703


<210>  246
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL18 light chain with signal sequence

<400>  246

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Thr Arg Ser Val Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  247
<211>  703
<212>  DNA
<213>  artificial

<220>
<223>  VL25 light chain with signal sequence

<400>  247
atgggatgga gctgtatcat cctcttcttg gtggcaacag ctacaggcgt gcactcttcc       60

tctgagctga cccaggatcc tgctgtgtct gtggccctgg gccagaccgt caggatcacc      120

tgccagggcg atagcctgag aacctactac gcctcctggt atcagcagaa gcctggacag      180

gcccctgtgc tggtgatcta cggcaagcac aagaggccat ccggcatccc tgacagattc      240

tccggctcct cctctggcaa taccgcctcc ctgaccatca ctggggctca ggcggaagac      300

gaggctgact attactgtac gacgcggagc aacaagggca acccccatgt tctgttcggc      360

ggagggaccc agctcaccgt tttaggtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt cat                        703


<210>  248
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  VL25 light chain with signal sequence

<400>  248

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 
            20                  25                  30          


Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 
        35                  40                  45              


Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Gly Lys His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Arg Ser Asn Lys 
            100                 105                 110         


Gly Asn Pro His Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


