                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> BIOMARKERS OF MYOCARDIAL ISCHEMIA

<130> 02240-270451

<140>
<141>

<150> 61/128,688
<151> 2008-05-23

<160> 44    

<170> PatentIn version 3.5

<210> 1
<211> 474
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Lys Glu Leu Ala Lys Leu Val Asn Lys Arg Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
465                 470                 


<210> 2
<211> 415
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Pro Phe Leu Tyr Leu Val Leu Leu Val Leu Gly Leu His Ala 
1               5                   10                  15      


Thr Ile His Cys Ala Ser Pro Glu Gly Lys Val Thr Ala Cys His Ser 
            20                  25                  30          


Ser Gln Pro Asn Ala Thr Leu Tyr Lys Met Ser Ser Ile Asn Ala Asp 
        35                  40                  45              


Phe Ala Phe Asn Leu Tyr Arg Arg Phe Thr Val Glu Thr Pro Asp Lys 
    50                  55                  60                  


Asn Ile Phe Phe Ser Pro Val Ser Ile Ser Ala Ala Leu Val Met Leu 
65                  70                  75                  80  


Ser Phe Gly Ala Cys Cys Ser Thr Gln Thr Glu Ile Val Glu Thr Leu 
                85                  90                  95      


Gly Phe Asn Leu Thr Asp Thr Pro Met Val Glu Ile Gln His Gly Phe 
            100                 105                 110         


Gln His Leu Ile Cys Ser Leu Asn Phe Pro Lys Lys Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Gly Asn Ala Leu Phe Ile Gly Lys His Leu Lys Pro Leu Ala 
    130                 135                 140                 


Lys Phe Leu Asn Asp Val Lys Thr Leu Tyr Glu Thr Glu Val Phe Ser 
145                 150                 155                 160 


Thr Asp Phe Ser Asn Ile Ser Ala Ala Lys Gln Glu Ile Asn Ser His 
                165                 170                 175     


Val Glu Met Gln Thr Lys Gly Lys Val Val Gly Leu Ile Gln Asp Leu 
            180                 185                 190         


Lys Pro Asn Thr Ile Met Val Leu Val Asn Tyr Ile His Phe Lys Ala 
        195                 200                 205             


Gln Trp Ala Asn Pro Phe Asp Pro Ser Lys Thr Glu Asp Ser Ser Ser 
    210                 215                 220                 


Phe Leu Ile Asp Lys Thr Thr Thr Val Gln Val Pro Met Met His Gln 
225                 230                 235                 240 


Met Glu Gln Tyr Tyr His Leu Val Asp Met Glu Leu Asn Cys Thr Val 
                245                 250                 255     


Leu Gln Met Asp Tyr Ser Lys Asn Ala Leu Ala Leu Phe Val Leu Pro 
            260                 265                 270         


Lys Glu Gly Gln Met Glu Ser Val Glu Ala Ala Met Ser Ser Lys Thr 
        275                 280                 285             


Leu Lys Lys Trp Asn Arg Leu Leu Gln Lys Gly Trp Val Asp Leu Phe 
    290                 295                 300                 


Val Pro Lys Phe Ser Ile Ser Ala Thr Tyr Asp Leu Gly Ala Thr Leu 
305                 310                 315                 320 


Leu Lys Met Gly Ile Gln His Ala Tyr Ser Glu Asn Ala Asp Phe Ser 
                325                 330                 335     


Gly Leu Thr Glu Asp Asn Gly Leu Lys Leu Ser Asn Ala Ala His Lys 
            340                 345                 350         


Ala Val Leu His Ile Gly Glu Lys Gly Thr Glu Ala Ala Ala Val Pro 
        355                 360                 365             


Glu Val Glu Leu Ser Asp Gln Pro Glu Asn Thr Phe Leu His Pro Ile 
    370                 375                 380                 


Ile Gln Ile Asp Arg Ser Phe Met Leu Leu Ile Leu Glu Arg Ser Thr 
385                 390                 395                 400 


Arg Ser Ile Leu Phe Leu Gly Lys Val Val Asn Pro Thr Glu Ala 
                405                 410                 415 


<210> 3
<211> 338
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln 
            20                  25                  30          


Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro 
        35                  40                  45              


Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val 
    50                  55                  60                  


Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 
65                  70                  75                  80  


Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 
                85                  90                  95      


Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe 
            100                 105                 110         


Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu 
        115                 120                 125             


Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu 
    130                 135                 140                 


Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn 
145                 150                 155                 160 


Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val 
                165                 170                 175     


Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
            180                 185                 190         


Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu 
        195                 200                 205             


Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 
    210                 215                 220                 


Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu 
225                 230                 235                 240 


Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu 
                245                 250                 255     


Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val 
            260                 265                 270         


Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys 
        275                 280                 285             


Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 
    290                 295                 300                 


Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser 
305                 310                 315                 320 


Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr 
                325                 330                 335     


Leu Asn 
        


<210> 4
<211> 136
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Asn Val Pro His Lys Ser Ser Leu Pro Glu Gly Ile Arg Pro 
1               5                   10                  15      


Gly Thr Val Leu Arg Ile Arg Gly Leu Val Pro Pro Asn Ala Ser Arg 
            20                  25                  30          


Phe His Val Asn Leu Leu Cys Gly Glu Glu Gln Gly Ser Asp Ala Ala 
        35                  40                  45              


Leu His Phe Asn Pro Arg Leu Asp Thr Ser Glu Val Val Phe Asn Ser 
    50                  55                  60                  


Lys Glu Gln Gly Ser Trp Gly Arg Glu Glu Arg Gly Pro Gly Val Pro 
65                  70                  75                  80  


Phe Gln Arg Gly Gln Pro Phe Glu Val Leu Ile Ile Ala Ser Asp Asp 
                85                  90                  95      


Gly Phe Lys Ala Val Val Gly Asp Ala Gln Tyr His His Phe Arg His 
            100                 105                 110         


Arg Leu Pro Leu Ala Arg Val Arg Leu Val Glu Val Gly Gly Asp Val 
        115                 120                 125             


Gln Leu Asp Ser Val Arg Ile Phe 
    130                 135     


<210> 5
<211> 567
<212> PRT
<213> Homo sapiens

<400> 5
Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gly Lys Glu Gly Arg Gly Pro 
65                  70                  75                  80  


Arg Pro His Ser Gln Pro Trp Leu Gly Glu Arg Val Gly Cys Ser His 
                85                  90                  95      


Ile Pro Pro Ser Ile Val Gln Pro Pro Pro Ser Gln Glu Ala Thr Pro 
            100                 105                 110         


Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu Pro Ala Glu Lys Glu 
        115                 120                 125             


Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro Leu Gln Lys Glu Leu 
    130                 135                 140                 


Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu Gly Thr Pro Ala Pro 
145                 150                 155                 160 


Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser Trp Asn Ala Ala Gln 
                165                 170                 175     


His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp Gly His Arg Leu Asp 
            180                 185                 190         


Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn Leu Asn Gln Ile Cys 
        195                 200                 205             


Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro Trp Asn Leu Pro Gln 
    210                 215                 220                 


Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu Thr Leu Asn Phe Leu 
225                 230                 235                 240 


Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg Ser His Thr Asn Arg 
                245                 250                 255     


Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala Met Ser Arg Phe Cys 
            260                 265                 270         


Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His Trp Cys Cys Thr Arg 
        275                 280                 285             


Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu Glu Ala Pro Gln Pro 
    290                 295                 300                 


His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln Pro Asp Ile Ser Ser 
305                 310                 315                 320 


Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro Thr Leu Asp Asn Ile 
                325                 330                 335     


Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser Val Pro Arg Asn Leu 
            340                 345                 350         


Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu Ala Leu Ile Gln Leu 
        355                 360                 365             


Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly Asn Asn His Thr Cys 
    370                 375                 380                 


Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys Tyr Cys Asp Arg Glu 
385                 390                 395                 400 


Tyr Ala Val Lys Thr His His His Leu Cys Cys Arg His Pro Pro Ser 
                405                 410                 415     


Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala Pro Tyr Pro Asn Tyr 
            420                 425                 430         


Asp Arg Asp Ile Leu Thr Ile Asp Ile Gly Arg Val Thr Pro Asn Leu 
        435                 440                 445             


Met Gly His Leu Cys Gly Asn Gln Arg Val Leu Thr Lys His Lys His 
    450                 455                 460                 


Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg Cys Cys Asp Leu Pro 
465                 470                 475                 480 


Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu Lys Leu Thr Phe Ile 
                485                 490                 495     


Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp Arg Asp Pro Ala Leu 
            500                 505                 510         


Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val Asn Cys Phe Asn Ile 
        515                 520                 525             


Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly Asp Thr Glu Asn Ala 
    530                 535                 540                 


Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly Thr Asn Ile Ser Ser 
545                 550                 555                 560 


Thr Ser Glu Pro Lys Glu Glu 
                565         


<210> 6
<211> 402
<212> PRT
<213> Homo sapiens

<400> 6
Met Lys Pro Asn Ile Ile Phe Val Leu Ser Leu Leu Leu Ile Leu Glu 
1               5                   10                  15      


Lys Gln Ala Ala Val Met Gly Gln Lys Gly Gly Ser Lys Gly Arg Leu 
            20                  25                  30          


Pro Ser Glu Phe Ser Gln Phe Pro His Gly Gln Lys Gly Gln His Tyr 
        35                  40                  45              


Ser Gly Gln Lys Gly Lys Gln Gln Thr Glu Ser Lys Gly Ser Phe Ser 
    50                  55                  60                  


Ile Gln Tyr Thr Tyr His Val Asp Ala Asn Asp His Asp Gln Ser Arg 
65                  70                  75                  80  


Lys Ser Gln Gln Tyr Asp Leu Asn Ala Leu His Lys Thr Thr Lys Ser 
                85                  90                  95      


Gln Arg His Leu Gly Gly Ser Gln Gln Leu Leu His Asn Lys Gln Glu 
            100                 105                 110         


Gly Arg Asp His Asp Lys Ser Lys Gly His Phe His Arg Val Val Ile 
        115                 120                 125             


His His Lys Gly Gly Lys Ala His Arg Gly Thr Gln Asn Pro Ser Gln 
    130                 135                 140                 


Asp Gln Gly Asn Ser Pro Ser Gly Lys Gly Ile Ser Ser Gln Tyr Ser 
145                 150                 155                 160 


Asn Thr Glu Glu Arg Leu Trp Val His Gly Leu Ser Lys Glu Gln Thr 
                165                 170                 175     


Ser Val Ser Gly Ala Gln Lys Gly Arg Lys Gln Gly Gly Ser Gln Ser 
            180                 185                 190         


Ser Tyr Val Leu Gln Thr Glu Glu Leu Val Ala Asn Lys Gln Gln Arg 
        195                 200                 205             


Glu Thr Lys Asn Ser His Gln Asn Lys Gly His Tyr Gln Asn Val Val 
    210                 215                 220                 


Glu Val Arg Glu Glu His Ser Ser Lys Val Gln Thr Ser Leu Cys Pro 
225                 230                 235                 240 


Ala His Gln Asp Lys Leu Gln His Gly Ser Lys Asp Ile Phe Ser Thr 
                245                 250                 255     


Gln Asp Glu Leu Leu Val Tyr Asn Lys Asn Gln His Gln Thr Lys Asn 
            260                 265                 270         


Leu Asn Gln Asp Gln Gln His Gly Arg Lys Ala Asn Lys Ile Ser Tyr 
        275                 280                 285             


Gln Ser Ser Ser Thr Glu Glu Arg Arg Leu His Tyr Gly Glu Asn Gly 
    290                 295                 300                 


Val Gln Lys Asp Val Ser Gln Arg Ser Ile Tyr Ser Gln Thr Glu Lys 
305                 310                 315                 320 


Leu Val Ala Gly Lys Ser Gln Ile Gln Ala Pro Asn Pro Lys Gln Glu 
                325                 330                 335     


Pro Trp His Gly Glu Asn Ala Lys Gly Glu Ser Gly Gln Ser Thr Asn 
            340                 345                 350         


Arg Glu Gln Asp Leu Leu Ser His Glu Gln Lys Gly Arg His Gln His 
        355                 360                 365             


Gly Ser His Gly Gly Leu Asp Ile Val Ile Ile Glu Gln Glu Asp Asp 
    370                 375                 380                 


Ser Asp Arg His Leu Ala Gln His Leu Asn Asn Asp Arg Asn Pro Leu 
385                 390                 395                 400 


Phe Thr 
        


<210> 7
<211> 484
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Gly Pro Trp Thr Phe Thr Leu Leu Cys Gly Leu Leu Ala Ala 
1               5                   10                  15      


Thr Leu Ile Gln Ala Thr Leu Ser Pro Thr Ala Val Leu Ile Leu Gly 
            20                  25                  30          


Pro Lys Val Ile Lys Glu Lys Leu Thr Gln Glu Leu Lys Asp His Asn 
        35                  40                  45              


Ala Thr Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu 
    50                  55                  60                  


Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Thr Val 
65                  70                  75                  80  


Leu Lys His Ile Ile Trp Leu Lys Val Ile Thr Ala Asn Ile Leu Gln 
                85                  90                  95      


Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile 
            100                 105                 110         


Pro Leu Asp Met Val Ala Gly Phe Asn Thr Pro Leu Val Lys Thr Ile 
        115                 120                 125             


Val Glu Phe His Met Thr Thr Glu Ala Gln Ala Thr Ile Arg Met Asp 
    130                 135                 140                 


Thr Ser Ala Ser Gly Pro Thr Arg Leu Val Leu Ser Asp Cys Ala Thr 
145                 150                 155                 160 


Ser His Gly Ser Leu Arg Ile Gln Leu Leu His Lys Leu Ser Phe Leu 
                165                 170                 175     


Val Asn Ala Leu Ala Lys Gln Val Met Asn Leu Leu Val Pro Ser Leu 
            180                 185                 190         


Pro Asn Leu Val Lys Asn Gln Leu Cys Pro Val Ile Glu Ala Ser Phe 
        195                 200                 205             


Asn Gly Met Tyr Ala Asp Leu Leu Gln Leu Val Lys Val Pro Ile Ser 
    210                 215                 220                 


Leu Ser Ile Asp Arg Leu Glu Phe Asp Leu Leu Tyr Pro Ala Ile Lys 
225                 230                 235                 240 


Gly Asp Thr Ile Gln Leu Tyr Leu Gly Ala Lys Leu Leu Asp Ser Gln 
                245                 250                 255     


Gly Lys Val Thr Lys Trp Phe Asn Asn Ser Ala Ala Ser Leu Thr Met 
            260                 265                 270         


Pro Thr Leu Asp Asn Ile Pro Phe Ser Leu Ile Val Ser Gln Asp Val 
        275                 280                 285             


Val Lys Ala Ala Val Ala Ala Val Leu Ser Pro Glu Glu Phe Met Val 
    290                 295                 300                 


Leu Leu Asp Ser Val Leu Pro Glu Ser Ala His Arg Leu Lys Ser Ser 
305                 310                 315                 320 


Ile Gly Leu Ile Asn Glu Lys Ala Ala Asp Lys Leu Gly Ser Thr Gln 
                325                 330                 335     


Ile Val Lys Ile Leu Thr Gln Asp Thr Pro Glu Phe Phe Ile Asp Gln 
            340                 345                 350         


Gly His Ala Lys Val Ala Gln Leu Ile Val Leu Glu Val Phe Pro Ser 
        355                 360                 365             


Ser Glu Ala Leu Arg Pro Leu Phe Thr Leu Gly Ile Glu Ala Ser Ser 
    370                 375                 380                 


Glu Ala Gln Phe Tyr Thr Lys Gly Asp Gln Leu Ile Leu Asn Leu Asn 
385                 390                 395                 400 


Asn Ile Ser Ser Asp Arg Ile Gln Leu Met Asn Ser Gly Ile Gly Trp 
                405                 410                 415     


Phe Gln Pro Asp Val Leu Lys Asn Ile Ile Thr Glu Ile Ile His Ser 
            420                 425                 430         


Ile Leu Leu Pro Asn Gln Asn Gly Lys Leu Arg Ser Gly Val Pro Val 
        435                 440                 445             


Ser Leu Val Lys Ala Leu Gly Phe Glu Ala Ala Glu Ser Ser Leu Thr 
    450                 455                 460                 


Lys Asp Ala Leu Val Leu Thr Pro Ala Ser Leu Trp Lys Pro Ser Ser 
465                 470                 475                 480 


Pro Val Ser Gln 
                


<210> 8
<211> 147
<212> PRT
<213> Homo sapiens

<400> 8
Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          


Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              


Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  


Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  


Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      


Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         


Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             


Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 


Arg Arg Pro 
145         


<210> 9
<211> 597
<212> PRT
<213> Homo sapiens

<400> 9
Met His Pro Pro Lys Thr Pro Ser Gly Ala Leu His Arg Lys Arg Lys 
1               5                   10                  15      


Met Ala Ala Trp Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile 
            20                  25                  30          


Leu Phe Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly 
        35                  40                  45              


Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile 
    50                  55                  60                  


Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr 
65                  70                  75                  80  


Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr Cys 
                85                  90                  95      


Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Tyr Lys Arg 
            100                 105                 110         


Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile Lys Thr 
        115                 120                 125             


Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu Gly Phe 
    130                 135                 140                 


Phe Leu Ile Gly Ser Thr Thr Ser Arg Cys Glu Val Gln Asp Arg Gly 
145                 150                 155                 160 


Val Gly Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys Cys Lys 
                165                 170                 175     


Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu Asn Phe 
            180                 185                 190         


Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg Phe Ser 
        195                 200                 205             


Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn Glu Thr Ile 
    210                 215                 220                 


Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu Lys Ile Thr Cys Arg 
225                 230                 235                 240 


Lys Pro Asp Val Ser His Gly Glu Met Val Ser Gly Phe Gly Pro Ile 
                245                 250                 255     


Tyr Asn Tyr Lys Asp Thr Ile Val Phe Lys Cys Gln Lys Gly Phe Val 
            260                 265                 270         


Leu Arg Gly Ser Ser Val Ile His Cys Asp Ala Asp Ser Lys Trp Asn 
        275                 280                 285             


Pro Ser Pro Pro Ala Cys Glu Pro Asn Ser Cys Ile Asn Leu Pro Asp 
    290                 295                 300                 


Ile Pro His Ala Ser Trp Glu Thr Tyr Pro Arg Pro Thr Lys Glu Asp 
305                 310                 315                 320 


Val Tyr Val Val Gly Thr Val Leu Arg Tyr Arg Cys His Pro Gly Tyr 
                325                 330                 335     


Lys Pro Thr Thr Asp Glu Pro Thr Thr Val Ile Cys Gln Lys Asn Leu 
            340                 345                 350         


Arg Trp Thr Pro Tyr Gln Gly Cys Glu Ala Leu Cys Cys Pro Glu Pro 
        355                 360                 365             


Lys Leu Asn Asn Gly Glu Ile Thr Gln His Arg Lys Ser Arg Pro Ala 
    370                 375                 380                 


Asn His Cys Val Tyr Phe Tyr Gly Asp Glu Ile Ser Phe Ser Cys His 
385                 390                 395                 400 


Glu Thr Ser Arg Phe Ser Ala Ile Cys Gln Gly Asp Gly Thr Trp Ser 
                405                 410                 415     


Pro Arg Thr Pro Ser Cys Gly Asp Ile Cys Asn Phe Pro Pro Lys Ile 
            420                 425                 430         


Ala His Gly His Tyr Lys Gln Ser Ser Ser Tyr Ser Phe Phe Lys Glu 
        435                 440                 445             


Glu Ile Ile Tyr Glu Cys Asp Lys Gly Tyr Ile Leu Val Gly Gln Ala 
    450                 455                 460                 


Lys Leu Ser Cys Ser Tyr Ser His Trp Ser Ala Pro Ala Pro Gln Cys 
465                 470                 475                 480 


Lys Ala Leu Cys Arg Lys Pro Glu Leu Val Asn Gly Arg Leu Ser Val 
                485                 490                 495     


Asp Lys Asp Gln Tyr Val Glu Pro Glu Asn Val Thr Ile Gln Cys Asp 
            500                 505                 510         


Ser Gly Tyr Gly Val Val Gly Pro Gln Ser Ile Thr Cys Ser Gly Asn 
        515                 520                 525             


Arg Thr Trp Tyr Pro Glu Val Pro Lys Cys Glu Trp Glu Thr Pro Glu 
    530                 535                 540                 


Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 
545                 550                 555                 560 


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
                565                 570                 575     


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr 
            580                 585                 590         


Leu Asp Lys Glu Leu 
        595         


<210> 10
<211> 458
<212> PRT
<213> Homo sapiens

<400> 10
Met Ser Asp Leu Leu Ser Val Phe Leu His Leu Leu Leu Leu Phe Lys 
1               5                   10                  15      


Leu Val Ala Pro Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val 
            20                  25                  30          


Arg Thr Leu Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val 
        35                  40                  45              


Tyr Ser Ile Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu 
    50                  55                  60                  


Phe Ser Asp His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys 
65                  70                  75                  80  


Tyr Val Gly Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met 
                85                  90                  95      


Leu Gln Leu Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln 
            100                 105                 110         


Arg Ile Val Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser 
        115                 120                 125             


Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys 
    130                 135                 140                 


Pro Gly Tyr Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn 
145                 150                 155                 160 


Arg Asn Phe Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr 
                165                 170                 175     


Gly Gly Pro Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln 
            180                 185                 190         


Val Glu Pro Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn 
        195                 200                 205             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr 
    210                 215                 220                 


Pro Tyr Asp Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr 
225                 230                 235                 240 


Ala Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys 
                245                 250                 255     


Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly 
            260                 265                 270         


Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu 
        275                 280                 285             


Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu 
    290                 295                 300                 


Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu 
305                 310                 315                 320 


Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu 
                325                 330                 335     


Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn 
            340                 345                 350         


Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val 
        355                 360                 365             


Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile 
    370                 375                 380                 


Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr 
385                 390                 395                 400 


Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
                405                 410                 415     


Arg Ser Ile Pro Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg 
            420                 425                 430         


His Gly Val Arg Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met 
        435                 440                 445             


Glu Met Arg Gln Leu Gln Arg Gly Pro Ala 
    450                 455             


<210> 11
<211> 1212
<212> PRT
<213> Homo sapiens

<400> 11
Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Phe Ile Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Arg Thr Ser Thr Gly Arg Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Ala His Pro Gly Ser Arg Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Ser Val Asp Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Val Ser Arg Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Val Ser Arg Gln Thr Arg Asn Glu Lys Gln 
                565                 570                 575     


Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Arg Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Arg Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Glu Ser Ser Arg Gln Ser Gly Thr His His Ala Glu Asn Ser 
        675                 680                 685             


Ser Gly Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala 
    690                 695                 700                 


Gly Glu Arg His Gly Ser His His Gln Gln Ser Ala Asp Ser Ser Arg 
705                 710                 715                 720 


His Ser Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser 
                725                 730                 735     


Gly His Arg Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His 
            740                 745                 750         


Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly 
        755                 760                 765             


Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Ala Gly 
    770                 775                 780                 


Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu 
785                 790                 795                 800 


Gln Ser Glu Ser Ala His Gly Arg Thr Arg Thr Ser Thr Gly Arg Arg 
                805                 810                 815     


Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala 
            820                 825                 830         


Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
        835                 840                 845             


Arg Gly Arg Gln Gly Ser His Tyr Glu Gln Ser Val Asp Arg Ser Gly 
    850                 855                 860                 


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
865                 870                 875                 880 


Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
                885                 890                 895     


Asn Asp Glu Gln Ser Gly Asp Gly Ser Arg His Ser Trp Ser His His 
            900                 905                 910         


His Glu Ala Ser Thr Gln Ala Asp Ser Ser Arg His Ser Gln Ser Gly 
        915                 920                 925             


Gln Gly Gln Ser Ala Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser 
    930                 935                 940                 


Val Ser Gln Asp Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg 
945                 950                 955                 960 


Trp Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu Gln 
                965                 970                 975     


Ser Arg Asp Gly Ser Arg His Pro Thr Ser His His Glu Asp Arg Ala 
            980                 985                 990         


Gly His Gly His Ser Ala Glu Ser  Ser Arg Gln Ser Gly  Thr His His 
        995                 1000                 1005             


Ala Glu  Asn Ser Ser Gly Gly  Gln Ala Ala Ser Ser  His Glu Gln 
    1010                 1015                 1020             


Ala Arg  Ser Ser Ala Gly Glu  Arg His Gly Ser His  His Gln Gln 
    1025                 1030                 1035             


Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile Gly His  Gly Gln Ala 
    1040                 1045                 1050             


Ser Ser  Ala Val Arg Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser 
    1055                 1060                 1065             


Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln 
    1070                 1075                 1080             


Ser Val  Ser Ala His Gly Gln  Ala Gly Pro His Gln  Gln Ser His 
    1085                 1090                 1095             


Gln Glu  Ser Thr Arg Gly Arg  Ser Ala Gly Arg Ser  Gly Arg Ser 
    1100                 1105                 1110             


Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His Glu Gln  Ser Glu Ser 
    1115                 1120                 1125             


Ala His  Gly Arg Ala Gly Pro  Ser Thr Gly Gly Arg  Gln Gly Ser 
    1130                 1135                 1140             


Arg His  Glu Gln Ala Arg Asp  Ser Ser Arg His Ser  Ala Ser Gln 
    1145                 1150                 1155             


Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro Gly Ser  Arg Arg Gly 
    1160                 1165                 1170             


Gly Arg  Gln Gly Ser Tyr His  Glu Gln Ser Val Asp  Arg Ser Gly 
    1175                 1180                 1185             


His Ser  Gly Ser His His Ser  His Thr Thr Ser Gln  Gly Arg Ser 
    1190                 1195                 1200             


Asp Ala  Ser His Gly Gln Ser  Gly Ser 
    1205                 1210         


<210> 12
<211> 1404
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      


Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly 
            20                  25                  30          


Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr 
        35                  40                  45              


Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys 
    50                  55                  60                  


Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg 
65                  70                  75                  80  


Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys 
                85                  90                  95      


Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser 
            100                 105                 110         


Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr 
        115                 120                 125             


Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys 
    130                 135                 140                 


Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val 
145                 150                 155                 160 


Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Thr Ile Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg 
            180                 185                 190         


Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr 
        195                 200                 205             


Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser 
    210                 215                 220                 


Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr 
225                 230                 235                 240 


Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys 
                245                 250                 255     


Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys 
            260                 265                 270         


Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu 
        275                 280                 285             


Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr 
    290                 295                 300                 


Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp 
305                 310                 315                 320 


Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu 
                325                 330                 335     


Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro 
            340                 345                 350         


Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro 
        355                 360                 365             


Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    370                 375                 380                 


Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
385                 390                 395                 400 


Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                405                 410                 415     


Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro 
            420                 425                 430         


Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro 
        435                 440                 445             


Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro 
    450                 455                 460                 


Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 


Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys 
                485                 490                 495     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
            500                 505                 510         


Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
        515                 520                 525             


Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser 
    530                 535                 540                 


Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro 
545                 550                 555                 560 


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
                565                 570                 575     


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
            580                 585                 590         


Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        595                 600                 605             


Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu 
    610                 615                 620                 


Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro 
625                 630                 635                 640 


Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro 
                645                 650                 655     


Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala 
            660                 665                 670         


Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        675                 680                 685             


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr 
    690                 695                 700                 


Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro 
705                 710                 715                 720 


Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr 
                725                 730                 735     


Thr Thr Lys Glu Pro Thr Ser Thr Thr Cys Asp Lys Pro Ala Pro Thr 
            740                 745                 750         


Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        755                 760                 765             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr 
    770                 775                 780                 


Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys 
785                 790                 795                 800 


Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp 
                805                 810                 815     


Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys 
            820                 825                 830         


Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu 
        835                 840                 845             


Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys 
    850                 855                 860                 


Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu 
865                 870                 875                 880 


Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro 
                885                 890                 895     


Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr 
            900                 905                 910         


Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro 
        915                 920                 925             


Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr 
    930                 935                 940                 


Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val 
945                 950                 955                 960 


Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu 
                965                 970                 975     


Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile 
            980                 985                 990         


Thr Thr Thr Glu Ile Met Asn Lys  Pro Glu Glu Thr Ala  Lys Pro Lys 
        995                 1000                 1005             


Asp Arg  Ala Thr Asn Ser Lys  Ala Thr Thr Pro Lys  Pro Gln Lys 
    1010                 1015                 1020             


Pro Thr  Lys Ala Pro Lys Lys  Pro Thr Ser Thr Lys  Lys Pro Lys 
    1025                 1030                 1035             


Thr Met  Pro Arg Val Arg Lys  Pro Lys Thr Thr Pro  Thr Pro Arg 
    1040                 1045                 1050             


Lys Met  Thr Ser Thr Met Pro  Glu Leu Asn Pro Thr  Ser Arg Ile 
    1055                 1060                 1065             


Ala Glu  Ala Met Leu Gln Thr  Thr Thr Arg Pro Asn  Gln Thr Pro 
    1070                 1075                 1080             


Asn Ser  Lys Leu Val Glu Val  Asn Pro Lys Ser Glu  Asp Ala Gly 
    1085                 1090                 1095             


Gly Ala  Glu Gly Glu Thr Pro  His Met Leu Leu Arg  Pro His Val 
    1100                 1105                 1110             


Phe Met  Pro Glu Val Thr Pro  Asp Met Asp Tyr Leu  Pro Arg Val 
    1115                 1120                 1125             


Pro Asn  Gln Gly Ile Ile Ile  Asn Pro Met Leu Ser  Asp Glu Thr 
    1130                 1135                 1140             


Asn Ile  Cys Asn Gly Lys Pro  Val Asp Gly Leu Thr  Thr Leu Arg 
    1145                 1150                 1155             


Asn Gly  Thr Leu Val Ala Phe  Arg Gly His Tyr Phe  Trp Met Leu 
    1160                 1165                 1170             


Ser Pro  Phe Ser Pro Pro Ser  Pro Ala Arg Arg Ile  Thr Glu Val 
    1175                 1180                 1185             


Trp Gly  Ile Pro Ser Pro Ile  Asp Thr Val Phe Thr  Arg Cys Asn 
    1190                 1195                 1200             


Cys Glu  Gly Lys Thr Phe Phe  Phe Lys Asp Ser Gln  Tyr Trp Arg 
    1205                 1210                 1215             


Phe Thr  Asn Asp Ile Lys Asp  Ala Gly Tyr Pro Lys  Pro Ile Phe 
    1220                 1225                 1230             


Lys Gly  Phe Gly Gly Leu Thr  Gly Gln Ile Val Ala  Ala Leu Ser 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Lys Asn Trp  Pro Glu Ser Val Tyr  Phe Phe Lys 
    1250                 1255                 1260             


Arg Gly  Gly Ser Ile Gln Gln  Tyr Ile Tyr Lys Gln  Glu Pro Val 
    1265                 1270                 1275             


Gln Lys  Cys Pro Gly Arg Arg  Pro Ala Leu Asn Tyr  Pro Val Tyr 
    1280                 1285                 1290             


Gly Glu  Thr Thr Gln Val Arg  Arg Arg Arg Phe Glu  Arg Ala Ile 
    1295                 1300                 1305             


Gly Pro  Ser Gln Thr His Thr  Ile Arg Ile Gln Tyr  Ser Pro Ala 
    1310                 1315                 1320             


Arg Leu  Ala Tyr Gln Asp Lys  Gly Val Leu His Asn  Glu Val Lys 
    1325                 1330                 1335             


Val Ser  Ile Leu Trp Arg Gly  Leu Pro Asn Val Val  Thr Ser Ala 
    1340                 1345                 1350             


Ile Ser  Leu Pro Asn Ile Arg  Lys Pro Asp Gly Tyr  Asp Tyr Tyr 
    1355                 1360                 1365             


Ala Phe  Ser Lys Asp Gln Tyr  Tyr Asn Ile Asp Val  Pro Ser Arg 
    1370                 1375                 1380             


Thr Ala  Arg Ala Ile Thr Thr  Arg Ser Gly Gln Thr  Leu Ser Lys 
    1385                 1390                 1395             


Val Trp  Tyr Asn Cys Pro 
    1400                 


<210> 13
<211> 367
<212> PRT
<213> Homo sapiens

<400> 13
Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys 
    130                 135                 140                 


Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val 
145                 150                 155                 160 


Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn 
                165                 170                 175     


Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro 
            180                 185                 190         


Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys 
        195                 200                 205             


Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu 
    210                 215                 220                 


Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly 
225                 230                 235                 240 


Ala Glu Val Ala Val Thr Cys Thr Val Phe Gln Thr Gln Pro Val Thr 
                245                 250                 255     


Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val 
            260                 265                 270         


Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu 
        275                 280                 285             


Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro 
    290                 295                 300                 


Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe 
305                 310                 315                 320 


Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro 
                325                 330                 335     


Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly 
            340                 345                 350         


Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365         


<210> 14
<211> 249
<212> PRT
<213> Homo sapiens

<400> 14
Met Asn Pro Phe Leu Ile Leu Ala Phe Val Gly Ala Ala Gly Glu Val 
1               5                   10                  15      


Ala Val Pro Phe Asp Asp Asp Asp Lys Ile Val Gly Gly Tyr Thr Cys 
            20                  25                  30          


Glu Glu Asn Ser Leu Pro Tyr Gln Val Ser Leu Asn Ser Gly Ser His 
        35                  40                  45              


Phe Cys Gly Gly Ser Leu Ile Ser Glu Gln Trp Val Val Ser Ala Ala 
    50                  55                  60                  


His Cys Tyr Lys Thr Arg Ile Gln Val Arg Leu Gly Glu His Asn Ile 
65                  70                  75                  80  


Lys Val Leu Glu Gly Asn Glu Gln Phe Ile Asn Ala Ala Lys Ile Ile 
                85                  90                  95      


Arg His Pro Lys Tyr Asn Arg Asp Thr Leu Asp Asn Asp Ile Met Leu 
            100                 105                 110         


Ile Lys Leu Ser Ser Pro Ala Val Ile Asn Ala Arg Val Ser Thr Ile 
        115                 120                 125             


Ser Leu Pro Thr Thr Pro Pro Ala Ala Gly Thr Glu Cys Leu Ile Ser 
    130                 135                 140                 


Gly Trp Gly Asn Thr Leu Ser Phe Gly Ala Asp Tyr Pro Asp Glu Leu 
145                 150                 155                 160 


Lys Cys Leu Asp Ala Pro Val Leu Thr Gln Ala Glu Cys Lys Ala Ser 
                165                 170                 175     


Tyr Pro Gly Lys Ile Thr Asn Ser Met Phe Cys Val Gly Phe Leu Glu 
            180                 185                 190         


Gly Gly Lys Asp Ser Cys Gln Arg Asp Ser Gly Gly Pro Val Val Cys 
        195                 200                 205             


Asn Gly Gln Leu Gln Gly Val Val Ser Trp Gly His Gly Cys Ala Trp 
    210                 215                 220                 


Lys Asn Arg Pro Gly Val Tyr Thr Lys Val Tyr Asn Tyr Val Asp Trp 
225                 230                 235                 240 


Ile Lys Asp Thr Ile Ala Ala Asn Ser 
                245                 


<210> 15
<211> 298
<212> PRT
<213> Homo sapiens

<400> 15
Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210> 16
<211> 1049
<212> PRT
<213> Homo sapiens

<400> 16
Met Asp Trp Ser Phe Phe Arg Val Val Ala Val Leu Phe Ile Phe Leu 
1               5                   10                  15      


Val Val Val Glu Val Asn Ser Glu Phe Arg Ile Gln Val Arg Asp Tyr 
            20                  25                  30          


Asn Thr Lys Asn Gly Thr Ile Lys Trp His Ser Ile Arg Arg Gln Lys 
        35                  40                  45              


Arg Glu Trp Ile Lys Phe Ala Ala Ala Cys Arg Glu Gly Glu Asp Asn 
    50                  55                  60                  


Ser Lys Arg Asn Pro Ile Ala Lys Ile His Ser Asp Cys Ala Ala Asn 
65                  70                  75                  80  


Gln Gln Val Thr Tyr Arg Ile Ser Gly Val Gly Ile Asp Gln Pro Pro 
                85                  90                  95      


Tyr Gly Ile Phe Val Ile Asn Gln Lys Thr Gly Glu Ile Asn Ile Thr 
            100                 105                 110         


Ser Ile Val Asp Arg Glu Val Thr Pro Phe Phe Ile Ile Tyr Cys Arg 
        115                 120                 125             


Ala Leu Asn Ser Met Gly Gln Asp Leu Glu Arg Pro Leu Glu Leu Arg 
    130                 135                 140                 


Val Arg Val Leu Asp Ile Asn Asp Asn Pro Pro Val Phe Ser Met Ala 
145                 150                 155                 160 


Thr Phe Ala Gly Gln Ile Glu Glu Asn Ser Asn Ala Asn Thr Leu Val 
                165                 170                 175     


Met Ile Leu Asn Ala Thr Asp Ala Asp Glu Pro Asn Asn Leu Asn Ser 
            180                 185                 190         


Lys Ile Ala Phe Lys Ile Ile Arg Gln Glu Pro Ser Asp Ser Pro Met 
        195                 200                 205             


Phe Ile Ile Asn Arg Asn Thr Gly Glu Ile Arg Thr Met Asn Asn Phe 
    210                 215                 220                 


Leu Asp Arg Glu Gln Tyr Gly Gln Tyr Ala Leu Ala Val Arg Gly Ser 
225                 230                 235                 240 


Asp Arg Asp Gly Gly Ala Asp Gly Met Ser Ala Glu Cys Glu Cys Asn 
                245                 250                 255     


Ile Lys Ile Leu Asp Val Asn Asp Asn Ile Pro Tyr Met Glu Gln Ser 
            260                 265                 270         


Ser Tyr Thr Ile Glu Ile Gln Glu Asn Thr Leu Asn Ser Asn Leu Leu 
        275                 280                 285             


Glu Ile Arg Val Ile Asp Leu Asp Glu Glu Phe Ser Ala Asn Trp Met 
    290                 295                 300                 


Ala Val Ile Phe Phe Ile Ser Gly Asn Glu Gly Asn Trp Phe Glu Ile 
305                 310                 315                 320 


Glu Met Asn Glu Arg Thr Asn Val Gly Ile Leu Lys Val Val Lys Pro 
                325                 330                 335     


Leu Asp Tyr Glu Ala Met Gln Ser Leu Gln Leu Ser Ile Gly Val Arg 
            340                 345                 350         


Asn Lys Ala Glu Phe His His Ser Ile Met Ser Gln Tyr Lys Leu Lys 
        355                 360                 365             


Ala Ser Ala Ile Ser Val Thr Val Leu Asn Val Ile Glu Gly Pro Val 
    370                 375                 380                 


Phe Arg Pro Gly Ser Lys Thr Tyr Val Val Thr Gly Asn Met Gly Ser 
385                 390                 395                 400 


Asn Asp Lys Val Gly Asp Phe Val Ala Thr Asp Leu Asp Thr Gly Arg 
                405                 410                 415     


Pro Ser Thr Thr Val Arg Tyr Val Met Gly Asn Asn Pro Ala Asp Leu 
            420                 425                 430         


Leu Ala Val Asp Ser Arg Thr Gly Lys Leu Thr Leu Lys Asn Lys Val 
        435                 440                 445             


Thr Lys Glu Gln Tyr Asn Met Leu Gly Gly Lys Tyr Gln Gly Thr Ile 
    450                 455                 460                 


Leu Ser Ile Asp Asp Asn Leu Gln Arg Thr Cys Thr Gly Thr Ile Asn 
465                 470                 475                 480 


Ile Asn Ile Gln Ser Phe Gly Asn Asp Asp Arg Thr Asn Thr Glu Pro 
                485                 490                 495     


Asn Thr Lys Ile Thr Thr Asn Thr Gly Arg Gln Glu Ser Thr Ser Ser 
            500                 505                 510         


Thr Asn Tyr Asp Thr Ser Thr Thr Ser Thr Asp Ser Ser Gln Val Tyr 
        515                 520                 525             


Ser Ser Glu Pro Gly Asn Gly Ala Lys Asp Leu Leu Ser Asp Asn Val 
    530                 535                 540                 


His Phe Gly Pro Ala Gly Ile Gly Leu Leu Ile Met Gly Phe Leu Val 
545                 550                 555                 560 


Leu Gly Leu Val Pro Phe Leu Met Ile Cys Cys Asp Cys Gly Gly Ala 
                565                 570                 575     


Pro Arg Ser Ala Ala Gly Phe Glu Pro Val Pro Glu Cys Ser Asp Gly 
            580                 585                 590         


Ala Ile His Ser Trp Ala Val Glu Gly Pro Gln Pro Glu Pro Arg Asp 
        595                 600                 605             


Ile Thr Thr Val Ile Pro Gln Ile Pro Pro Asp Asn Ala Asn Ile Ile 
    610                 615                 620                 


Glu Cys Ile Asp Asn Ser Gly Val Tyr Thr Asn Glu Tyr Gly Gly Arg 
625                 630                 635                 640 


Glu Met Gln Asp Leu Gly Gly Gly Glu Arg Met Thr Gly Phe Glu Leu 
                645                 650                 655     


Thr Glu Gly Val Lys Thr Ser Gly Met Pro Glu Ile Cys Gln Glu Tyr 
            660                 665                 670         


Ser Gly Thr Leu Arg Arg Asn Ser Met Arg Glu Cys Arg Glu Gly Gly 
        675                 680                 685             


Leu Asn Met Asn Phe Met Glu Ser Tyr Phe Cys Gln Lys Ala Tyr Ala 
    690                 695                 700                 


Tyr Ala Asp Glu Asp Glu Gly Arg Pro Ser Asn Asp Cys Leu Leu Ile 
705                 710                 715                 720 


Tyr Asp Ile Glu Gly Val Gly Ser Pro Ala Gly Ser Val Gly Cys Cys 
                725                 730                 735     


Ser Phe Ile Gly Glu Asp Leu Asp Asp Ser Phe Leu Asp Thr Leu Gly 
            740                 745                 750         


Pro Lys Phe Lys Lys Leu Ala Asp Ile Ser Leu Gly Lys Glu Ser Tyr 
        755                 760                 765             


Pro Asp Leu Asp Pro Ser Trp Pro Pro Gln Ser Thr Glu Pro Val Cys 
    770                 775                 780                 


Leu Pro Gln Glu Thr Glu Pro Val Val Ser Gly His Pro Pro Ile Ser 
785                 790                 795                 800 


Pro His Phe Gly Thr Thr Thr Val Ile Ser Glu Ser Thr Tyr Pro Ser 
                805                 810                 815     


Gly Pro Gly Val Leu His Pro Lys Pro Ile Leu Asp Pro Leu Gly Tyr 
            820                 825                 830         


Gly Asn Val Thr Val Thr Glu Ser Tyr Thr Thr Ser Asp Thr Leu Lys 
        835                 840                 845             


Pro Ser Val His Val His Asp Asn Arg Pro Ala Ser Asn Val Val Val 
    850                 855                 860                 


Thr Glu Arg Val Val Gly Pro Ile Ser Gly Ala Asp Leu His Gly Met 
865                 870                 875                 880 


Leu Glu Met Pro Asp Leu Arg Asp Gly Ser Asn Val Ile Val Thr Glu 
                885                 890                 895     


Arg Val Ile Ala Pro Ser Ser Ser Leu Pro Thr Ser Leu Thr Ile His 
            900                 905                 910         


His Pro Arg Glu Ser Ser Asn Val Val Val Thr Glu Arg Val Ile Gln 
        915                 920                 925             


Pro Thr Ser Gly Met Ile Gly Ser Leu Ser Met His Pro Glu Leu Ala 
    930                 935                 940                 


Asn Ala His Asn Val Ile Val Thr Glu Arg Val Val Ser Gly Ala Gly 
945                 950                 955                 960 


Val Thr Gly Ile Ser Gly Thr Thr Gly Ile Ser Gly Gly Ile Gly Ser 
                965                 970                 975     


Ser Gly Leu Val Gly Thr Ser Met Gly Ala Gly Ser Gly Ala Leu Ser 
            980                 985                 990         


Gly Ala Gly Ile Ser Gly Gly Gly  Ile Gly Leu Ser Ser  Leu Gly Gly 
        995                 1000                 1005             


Thr Ala  Ser Ile Gly His Met  Arg Ser Ser Ser Asp  His His Phe 
    1010                 1015                 1020             


Asn Gln  Thr Ile Gly Ser Ala  Ser Pro Ser Thr Ala  Arg Ser Arg 
    1025                 1030                 1035             


Ile Thr  Lys Tyr Ser Thr Val  Gln Tyr Ser Lys 
    1040                 1045                 


<210> 17
<211> 242
<212> PRT
<213> Homo sapiens

<400> 17
Met Ser Asn Pro Arg Ser Leu Glu Glu Glu Lys Tyr Asp Met Ser Gly 
1               5                   10                  15      


Ala Arg Leu Ala Leu Ile Leu Cys Val Thr Lys Ala Arg Glu Gly Ser 
            20                  25                  30          


Glu Glu Asp Leu Asp Ala Leu Glu His Met Phe Arg Gln Leu Arg Phe 
        35                  40                  45              


Glu Ser Thr Met Lys Arg Asp Pro Thr Ala Glu Gln Phe Gln Glu Glu 
    50                  55                  60                  


Leu Glu Lys Phe Gln Gln Ala Ile Asp Ser Arg Glu Asp Pro Val Ser 
65                  70                  75                  80  


Cys Ala Phe Val Val Leu Met Ala His Gly Arg Glu Gly Phe Leu Lys 
                85                  90                  95      


Gly Glu Asp Gly Glu Met Val Lys Leu Glu Asn Leu Phe Glu Ala Leu 
            100                 105                 110         


Asn Asn Lys Asn Cys Gln Ala Leu Arg Ala Lys Pro Lys Val Tyr Ile 
        115                 120                 125             


Ile Gln Ala Cys Arg Gly Glu Gln Arg Asp Pro Gly Glu Thr Val Gly 
    130                 135                 140                 


Gly Asp Glu Ile Val Met Val Ile Lys Asp Ser Pro Gln Thr Ile Pro 
145                 150                 155                 160 


Thr Tyr Thr Asp Ala Leu His Val Tyr Ser Thr Val Glu Gly Tyr Ile 
                165                 170                 175     


Ala Tyr Arg His Asp Gln Lys Gly Ser Cys Phe Ile Gln Thr Leu Val 
            180                 185                 190         


Asp Val Phe Thr Lys Arg Lys Gly His Ile Leu Glu Leu Leu Thr Glu 
        195                 200                 205             


Val Thr Arg Arg Met Ala Glu Ala Glu Leu Val Gln Glu Gly Lys Ala 
    210                 215                 220                 


Arg Lys Thr Asn Pro Glu Ile Gln Ser Thr Leu Arg Lys Arg Leu Tyr 
225                 230                 235                 240 


Leu Gln 
        


<210> 18
<211> 2850
<212> PRT
<213> Homo sapiens

<400> 18
Met Pro Lys Leu Leu Gln Gly Val Ile Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Gln Tyr Ala Thr Gln His Gly Glu Tyr Asp Thr Leu Asn Lys Ala Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Asn Glu Phe His Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asn Asp Pro Asp Thr Val Asp Ile Ile Leu Gln Ser Leu Asp Arg Asp 
    50                  55                  60                  


His Asn Lys Lys Val Asp Phe Thr Glu Tyr Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Val Gln Ala Arg Asn Lys Ile Ile Gly Lys Asp Tyr Cys Gln Val 
                85                  90                  95      


Ser Gly Ser Lys Leu Arg Asp Asp Thr His Gln His Gln Glu Glu Gln 
            100                 105                 110         


Glu Glu Thr Glu Lys Glu Glu Asn Lys Arg Gln Glu Ser Ser Phe Ser 
        115                 120                 125             


His Ser Ser Trp Ser Ala Gly Glu Asn Asp Ser Tyr Ser Arg Asn Val 
    130                 135                 140                 


Arg Gly Ser Leu Lys Pro Gly Thr Glu Ser Ile Ser Arg Arg Leu Ser 
145                 150                 155                 160 


Phe Gln Arg Asp Phe Ser Gly Gln His Asn Ser Tyr Ser Gly Gln Ser 
                165                 170                 175     


Ser Ser Tyr Gly Glu Gln Asn Ser Asp Ser His Gln Ser Ser Gly Arg 
            180                 185                 190         


Gly Gln Cys Gly Ser Gly Ser Gly Gln Ser Pro Asn Tyr Gly Gln His 
        195                 200                 205             


Gly Ser Gly Ser Gly Gln Ser Ser Ser Asn Asp Thr His Gly Ser Gly 
    210                 215                 220                 


Ser Gly Gln Ser Ser Gly Phe Ser Gln His Lys Ser Ser Ser Gly Gln 
225                 230                 235                 240 


Ser Ser Gly Tyr Ser Gln His Gly Ser Gly Ser Gly His Ser Ser Gly 
                245                 250                 255     


Tyr Gly Gln His Gly Ser Arg Ser Gly Gln Ser Ser Arg Gly Glu Arg 
            260                 265                 270         


His Arg Ser Ser Ser Gly Ser Ser Ser Ser Tyr Gly Gln His Gly Ser 
        275                 280                 285             


Gly Ser Arg Gln Ser Leu Gly His Gly Arg Gln Gly Ser Gly Ser Arg 
    290                 295                 300                 


Gln Ser Pro Ser His Val Arg His Gly Ser Gly Ser Gly His Ser Ser 
305                 310                 315                 320 


Ser His Gly Gln His Gly Ser Gly Ser Ser Tyr Ser Tyr Ser Arg Gly 
                325                 330                 335     


His Tyr Glu Ser Gly Ser Gly Gln Thr Ser Gly Phe Gly Gln His Glu 
            340                 345                 350         


Ser Gly Ser Gly Gln Ser Ser Gly Tyr Ser Lys His Gly Ser Gly Ser 
        355                 360                 365             


Gly His Ser Ser Ser Gln Gly Gln His Gly Ser Thr Ser Gly Gln Ala 
    370                 375                 380                 


Ser Ser Ser Gly Gln His Gly Ser Ser Ser Arg Gln Ser Ser Ser Tyr 
385                 390                 395                 400 


Gly Gln His Glu Ser Ala Ser Arg His Ser Ser Gly Arg Gly Gln His 
                405                 410                 415     


Ser Ser Gly Ser Gly Gln Ser Pro Gly His Gly Gln Arg Gly Ser Gly 
            420                 425                 430         


Ser Gly Gln Ser Pro Ser Ser Gly Gln His Gly Thr Gly Phe Gly Arg 
        435                 440                 445             


Ser Ser Ser Ser Gly Pro Tyr Val Ser Gly Ser Gly Tyr Ser Ser Gly 
    450                 455                 460                 


Phe Gly His His Glu Ser Ser Ser Glu His Ser Ser Gly Tyr Thr Gln 
465                 470                 475                 480 


His Gly Ser Gly Ser Gly His Ser Ser Gly His Gly Gln His Gly Ser 
                485                 490                 495     


Arg Ser Gly Gln Ser Ser Arg Gly Glu Arg Gln Gly Ser Ser Ala Gly 
            500                 505                 510         


Ser Ser Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Arg Gln Ser Leu 
        515                 520                 525             


Gly His Ser Arg His Gly Ser Gly Ser Gly Gln Ser Pro Ser Pro Ser 
    530                 535                 540                 


Arg Gly Arg His Glu Ser Gly Ser Arg Gln Ser Ser Ser Tyr Gly Pro 
545                 550                 555                 560 


His Gly Tyr Gly Ser Gly Arg Ser Ser Ser Arg Gly Pro Tyr Glu Ser 
                565                 570                 575     


Gly Ser Gly His Ser Ser Gly Leu Gly His Gln Glu Ser Arg Ser Gly 
            580                 585                 590         


Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser Ser Gly His Ser Ser 
        595                 600                 605             


Thr His Gly Gln His Gly Ser Thr Ser Gly Gln Ser Ser Ser Cys Gly 
    610                 615                 620                 


Gln His Gly Ala Thr Ser Gly Gln Ser Ser Ser His Gly Gln His Gly 
625                 630                 635                 640 


Ser Gly Ser Ser Gln Ser Ser Arg Tyr Gly Gln Gln Gly Ser Gly Ser 
                645                 650                 655     


Gly Gln Ser Pro Ser Arg Gly Arg His Gly Ser Asp Phe Gly His Ser 
            660                 665                 670         


Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Gly Trp Ser Ser Ser Asn 
        675                 680                 685             


Gly Pro His Gly Ser Val Ser Gly Gln Ser Ser Gly Phe Gly His Lys 
    690                 695                 700                 


Ser Gly Ser Gly Gln Ser Ser Gly Tyr Ser Gln His Gly Ser Gly Ser 
705                 710                 715                 720 


Ser His Ser Ser Gly Tyr Arg Lys His Gly Ser Arg Ser Gly Gln Ser 
                725                 730                 735     


Ser Arg Ser Glu Gln His Gly Ser Ser Ser Gly Leu Ser Ser Ser Tyr 
            740                 745                 750         


Gly Gln His Gly Ser Gly Ser His Gln Ser Ser Gly His Gly Arg Gln 
        755                 760                 765             


Gly Ser Gly Ser Gly His Ser Pro Ser Arg Val Arg His Gly Ser Ser 
    770                 775                 780                 


Ser Gly His Ser Ser Ser His Gly Gln His Gly Ser Gly Thr Ser Cys 
785                 790                 795                 800 


Ser Ser Ser Cys Gly His Tyr Glu Ser Gly Ser Gly Gln Ala Ser Gly 
                805                 810                 815     


Phe Gly Gln His Glu Ser Gly Ser Gly Gln Gly Tyr Ser Gln His Gly 
            820                 825                 830         


Ser Ala Ser Gly His Phe Ser Ser Gln Gly Arg His Gly Ser Thr Ser 
        835                 840                 845             


Gly Gln Ser Ser Ser Ser Gly Gln His Asp Ser Ser Ser Gly Gln Ser 
    850                 855                 860                 


Ser Ser Tyr Gly Gln His Glu Ser Ala Ser His His Ala Ser Gly Arg 
865                 870                 875                 880 


Gly Arg His Gly Ser Gly Ser Gly Gln Ser Pro Gly His Gly Gln Arg 
                885                 890                 895     


Gly Ser Gly Ser Gly Gln Ser Pro Ser Tyr Gly Arg His Gly Ser Gly 
            900                 905                 910         


Ser Gly Arg Ser Ser Ser Ser Gly Arg His Gly Ser Gly Ser Gly Gln 
        915                 920                 925             


Ser Ser Gly Phe Gly His Lys Ser Ser Ser Gly Gln Ser Ser Gly Tyr 
    930                 935                 940                 


Thr Gln His Gly Ser Gly Ser Gly His Ser Ser Ser Tyr Glu Gln His 
945                 950                 955                 960 


Gly Ser Arg Ser Gly Gln Ser Ser Arg Ser Glu Gln His Gly Ser Ser 
                965                 970                 975     


Ser Gly Ser Ser Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Arg Gln 
            980                 985                 990         


Ser Leu Gly His Gly Gln His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser 
        995                 1000                 1005             


Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser 
    1010                 1015                 1020             


Tyr Gly  Pro Tyr Arg Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly 
    1025                 1030                 1035             


Pro Tyr  Glu Ser Gly Ser Gly  His Ser Ser Gly Leu  Gly His Arg 
    1040                 1045                 1050             


Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    1055                 1060                 1065             


Ser Ser  Gly His Ser Ser Thr  His Gly Gln His Gly  Ser Thr Ser 
    1070                 1075                 1080             


Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln 
    1085                 1090                 1095             


Ser Ser  Ser His Gly Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser 
    1100                 1105                 1110             


Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His 
    1115                 1120                 1125             


Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg 
    1130                 1135                 1140             


His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly 
    1145                 1150                 1155             


Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly His His  Glu Ser Ser 
    1160                 1165                 1170             


Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly 
    1175                 1180                 1185             


His Ser  Ser Gly Tyr Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser 
    1190                 1195                 1200             


Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser Gly Ser  Ser Ser His 
    1205                 1210                 1215             


Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly 
    1220                 1225                 1230             


Arg Gln  Gly Ser Gly Ser Gly  His Ser Pro Ser Arg  Gly Arg His 
    1235                 1240                 1245             


Gly Ser  Gly Leu Gly His Ser  Ser Ser His Gly Gln  His Gly Ser 
    1250                 1255                 1260             


Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Ser 
    1265                 1270                 1275             


Gly His  Ser Ser Val Phe Gly  Gln His Glu Ser Gly  Ser Gly His 
    1280                 1285                 1290             


Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly Ser Gly  His Phe Cys 
    1295                 1300                 1305             


Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe 
    1310                 1315                 1320             


Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser Ser Ser  Tyr Gly His 
    1325                 1330                 1335             


Arg Gly  Ser Gly Ser Ser Gln  Ser Ser Gly Tyr Gly  Arg His Gly 
    1340                 1345                 1350             


Ala Gly  Ser Gly Gln Ser Pro  Ser Arg Gly Arg His  Gly Ser Gly 
    1355                 1360                 1365             


Ser Gly  His Ser Ser Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly 
    1370                 1375                 1380             


Trp Ser  Ser Ser Ser Gly Arg  His Gly Ser Gly Ser  Gly Gln Ser 
    1385                 1390                 1395             


Ser Gly  Phe Gly His His Glu  Ser Ser Ser Trp Gln  Ser Ser Gly 
    1400                 1405                 1410             


Cys Thr  Gln His Gly Ser Gly  Ser Gly His Ser Ser  Ser Tyr Glu 
    1415                 1420                 1425             


Gln His  Gly Ser Arg Ser Gly  Gln Ser Ser Arg Gly  Glu Arg His 
    1430                 1435                 1440             


Gly Ser  Ser Ser Gly Ser Ser  Ser Ser Tyr Gly Gln  His Gly Ser 
    1445                 1450                 1455             


Gly Ser  Arg Gln Ser Leu Gly  His Gly Gln His Gly  Ser Gly Ser 
    1460                 1465                 1470             


Gly Gln  Ser Pro Ser Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser 
    1475                 1480                 1485             


Gly Gln  Ser Ser Ser Tyr Ser  Pro Tyr Gly Ser Gly  Ser Gly Trp 
    1490                 1495                 1500             


Ser Ser  Ser Arg Gly Pro Tyr  Glu Ser Gly Ser Ser  His Ser Ser 
    1505                 1510                 1515             


Gly Leu  Gly His Arg Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr 
    1520                 1525                 1530             


Gly Gln  His Gly Ser Ser Ser  Gly His Ser Ser Thr  His Gly Gln 
    1535                 1540                 1545             


His Gly  Ser Thr Ser Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly 
    1550                 1555                 1560             


Ala Ser  Ser Gly Gln Ser Ser  Ser His Gly Gln His  Gly Ser Gly 
    1565                 1570                 1575             


Ser Ser  Gln Ser Ser Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly 
    1580                 1585                 1590             


Gln Ser  Pro Gly His Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser 
    1595                 1600                 1605             


Pro Ser  Tyr Gly Arg His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser 
    1610                 1615                 1620             


Ser Gly  Gln His Gly Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly 
    1625                 1630                 1635             


His His  Glu Ser Ser Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His 
    1640                 1645                 1650             


Gly Ser  Gly Ser Gly His Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    1655                 1660                 1665             


Arg Ser  Gly Gln Ser Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser 
    1670                 1675                 1680             


Arg Ser  Ser Ser Arg Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln 
    1685                 1690                 1695             


Ser Ser  Gly His Gly Arg Gln  Gly Ser Gly Ser Gly  Gln Ser Pro 
    1700                 1705                 1710             


Ser Arg  Gly Arg His Gly Ser  Gly Leu Gly His Ser  Ser Ser His 
    1715                 1720                 1725             


Gly Gln  His Gly Ser Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro 
    1730                 1735                 1740             


Tyr Glu  Ser Arg Ser Gly His  Ser Ser Val Phe Gly  Gln His Glu 
    1745                 1750                 1755             


Ser Gly  Ser Gly His Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly 
    1760                 1765                 1770             


Ser Gly  His Phe Cys Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly 
    1775                 1780                 1785             


Gln Ser  Ser Thr Phe Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser 
    1790                 1795                 1800             


Ser Ser  His Gly Gln His Gly  Ser Gly Ser Ser Gln  Ser Ser Ser 
    1805                 1810                 1815             


Tyr Gly  Gln Gln Gly Ser Gly  Ser Gly Gln Ser Pro  Ser Arg Gly 
    1820                 1825                 1830             


Arg His  Gly Ser Gly Ser Gly  His Ser Ser Ser Tyr  Gly Gln His 
    1835                 1840                 1845             


Gly Ser  Gly Ser Gly Trp Ser  Ser Ser Ser Gly Arg  His Gly Ser 
    1850                 1855                 1860             


Gly Ser  Gly Gln Ser Ser Gly  Phe Gly His His Glu  Ser Ser Ser 
    1865                 1870                 1875             


Trp Gln  Ser Ser Gly Tyr Thr  Gln His Gly Ser Gly  Ser Gly His 
    1880                 1885                 1890             


Ser Ser  Ser Tyr Glu Gln His  Gly Ser Arg Ser Gly  Gln Ser Ser 
    1895                 1900                 1905             


Arg Gly  Glu Gln His Gly Ser  Ser Ser Gly Ser Ser  Ser Ser Tyr 
    1910                 1915                 1920             


Gly Gln  His Gly Ser Gly Ser  Arg Gln Ser Leu Gly  His Gly Gln 
    1925                 1930                 1935             


His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser Pro Ser  Arg Gly Arg 
    1940                 1945                 1950             


His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser Tyr Gly  Pro Tyr Gly 
    1955                 1960                 1965             


Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly Pro Tyr  Glu Ser Gly 
    1970                 1975                 1980             


Ser Gly  His Ser Ser Gly Leu  Gly His Arg Glu Ser  Arg Ser Gly 
    1985                 1990                 1995             


Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser Ser Ser  Gly His Ser 
    2000                 2005                 2010             


Ser Thr  His Gly Gln His Gly  Ser Ala Ser Gly Gln  Ser Ser Ser 
    2015                 2020                 2025             


Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln Ser Ser  Ser His Gly 
    2030                 2035                 2040             


Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser Gly Tyr  Gly Arg Gln 
    2045                 2050                 2055             


Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His Gly Gln  Arg Gly Ser 
    2060                 2065                 2070             


Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg His Gly  Ser Gly Ser 
    2075                 2080                 2085             


Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly Pro Gly  Leu Gly Glu 
    2090                 2095                 2100             


Ser Ser  Gly Phe Gly His His  Glu Ser Ser Ser Gly  Gln Ser Ser 
    2105                 2110                 2115             


Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly His Ser  Ser Gly Tyr 
    2120                 2125                 2130             


Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser Ser Arg  Gly Glu Arg 
    2135                 2140                 2145             


His Gly  Ser Ser Ser Gly Ser  Ser Ser Arg Tyr Gly  Gln His Gly 
    2150                 2155                 2160             


Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly Arg Gln  Gly Ser Gly 
    2165                 2170                 2175             


Ser Gly  His Ser Pro Ser Arg  Gly Arg His Gly Ser  Gly Ser Gly 
    2180                 2185                 2190             


His Ser  Ser Ser His Gly Gln  His Gly Ser Gly Ser  Gly Arg Ser 
    2195                 2200                 2205             


Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Ser Gly His  Ser Ser Val 
    2210                 2215                 2220             


Phe Gly  Gln His Glu Ser Gly  Ser Gly His Ser Ser  Ala Tyr Ser 
    2225                 2230                 2235             


Gln His  Gly Ser Gly Ser Gly  His Phe Cys Ser Gln  Gly Gln His 
    2240                 2245                 2250             


Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe Asp Gln  Glu Gly Ser 
    2255                 2260                 2265             


Ser Thr  Gly Gln Ser Ser Ser  His Gly Gln His Gly  Ser Gly Ser 
    2270                 2275                 2280             


Ser Gln  Ser Ser Ser Tyr Gly  Gln Gln Gly Ser Gly  Ser Gly Gln 
    2285                 2290                 2295             


Ser Pro  Ser Arg Gly Arg His  Gly Ser Gly Ser Gly  His Ser Ser 
    2300                 2305                 2310             


Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly Trp Ser  Ser Ser Ser 
    2315                 2320                 2325             


Gly Arg  His Gly Ser Gly Ser  Gly Gln Ser Ser Gly  Phe Gly His 
    2330                 2335                 2340             


His Glu  Ser Ser Ser Trp Gln  Ser Ser Gly Tyr Thr  Gln His Gly 
    2345                 2350                 2355             


Ser Gly  Ser Gly His Ser Ser  Ser Tyr Glu Gln His  Gly Ser Arg 
    2360                 2365                 2370             


Ser Gly  Gln Ser Ser Arg Gly  Glu Arg His Gly Ser  Ser Ser Gly 
    2375                 2380                 2385             


Ser Ser  Ser Ser Tyr Gly Gln  His Gly Ser Gly Ser  Arg Gln Ser 
    2390                 2395                 2400             


Leu Gly  His Gly Gln His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser 
    2405                 2410                 2415             


Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser 
    2420                 2425                 2430             


Tyr Ser  Pro Tyr Gly Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly 
    2435                 2440                 2445             


Pro Tyr  Glu Ser Gly Ser Gly  His Ser Ser Gly Leu  Gly His Arg 
    2450                 2455                 2460             


Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    2465                 2470                 2475             


Ser Ser  Gly His Ser Ser Thr  His Gly Gln His Gly  Ser Thr Ser 
    2480                 2485                 2490             


Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln 
    2495                 2500                 2505             


Ser Ser  Ser His Gly Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser 
    2510                 2515                 2520             


Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His 
    2525                 2530                 2535             


Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg 
    2540                 2545                 2550             


His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly 
    2555                 2560                 2565             


Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly His His  Glu Ser Ser 
    2570                 2575                 2580             


Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly 
    2585                 2590                 2595             


His Ser  Ser Gly Tyr Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser 
    2600                 2605                 2610             


Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser Gly Ser  Ser Ser His 
    2615                 2620                 2625             


Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly 
    2630                 2635                 2640             


Arg Gln  Gly Ser Gly Ser Gly  Gln Ser Pro Ser Arg  Gly Arg His 
    2645                 2650                 2655             


Gly Ser  Gly Leu Gly His Ser  Ser Ser His Gly Gln  His Gly Ser 
    2660                 2665                 2670             


Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Leu 
    2675                 2680                 2685             


Gly His  Ser Ser Val Phe Gly  Gln His Glu Ser Gly  Ser Gly His 
    2690                 2695                 2700             


Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly Ser Gly  His Phe Cys 
    2705                 2710                 2715             


Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe 
    2720                 2725                 2730             


Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser Ser Ser  Tyr Gly His 
    2735                 2740                 2745             


Arg Gly  Ser Gly Ser Ser Gln  Ser Ser Gly Tyr Gly  Arg His Gly 
    2750                 2755                 2760             


Ala Gly  Ser Gly Gln Ser Leu  Ser His Gly Arg His  Gly Ser Gly 
    2765                 2770                 2775             


Ser Gly  Gln Ser Ser Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly 
    2780                 2785                 2790             


Gln Ser  Ser Gly Tyr Ser Gln  His Gly Ser Gly Ser  Gly Gln Asp 
    2795                 2800                 2805             


Gly Tyr  Ser Tyr Cys Lys Gly  Gly Ser Asn His Asp  Gly Gly Ser 
    2810                 2815                 2820             


Ser Gly  Ser Tyr Phe Leu Ser  Phe Pro Ser Ser Thr  Ser Pro Tyr 
    2825                 2830                 2835             


Glu Tyr  Val Gln Glu Gln Arg  Cys Tyr Phe Tyr Gln  
    2840                 2845                 2850 


<210> 19
<211> 427
<212> PRT
<213> Homo sapiens

<400> 19
Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly 
            180                 185                 190         


Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys 
        195                 200                 205             


Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly 
    210                 215                 220                 


Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 
225                 230                 235                 240 


Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 
                245                 250                 255     


Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 
            260                 265                 270         


Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys 
        275                 280                 285             


Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val 
    290                 295                 300                 


Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp 
305                 310                 315                 320 


Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu 
                325                 330                 335     


Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn 
            340                 345                 350         


Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 
        355                 360                 365             


Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 
    370                 375                 380                 


Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 
385                 390                 395                 400 


Thr Ser His Leu Arg Ser Cys Glu Tyr Lys Gly Arg Pro Pro Lys Ala 
                405                 410                 415     


Gly Ala Glu Pro Ala Ser Glu Arg Glu Val Ser 
            420                 425         


<210> 20
<211> 418
<212> PRT
<213> Homo sapiens

<400> 20
Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Met Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210> 21
<211> 101
<212> PRT
<213> Homo sapiens

<400> 21
Met Ser Asn Thr Gln Ala Glu Arg Ser Ile Ile Gly Met Ile Asp Met 
1               5                   10                  15      


Phe His Lys Tyr Thr Arg Arg Asp Asp Lys Ile Glu Lys Pro Ser Leu 
            20                  25                  30          


Leu Thr Met Met Lys Glu Asn Phe Pro Asn Phe Leu Ser Ala Cys Asp 
        35                  40                  45              


Lys Lys Gly Thr Asn Tyr Leu Ala Asp Val Phe Glu Lys Lys Asp Lys 
    50                  55                  60                  


Asn Glu Asp Lys Lys Ile Asp Phe Ser Glu Phe Leu Ser Leu Leu Gly 
65                  70                  75                  80  


Asp Ile Ala Thr Asp Tyr His Lys Gln Ser His Gly Ala Ala Pro Cys 
                85                  90                  95      


Ser Gly Gly Ser Gln 
            100     


<210> 22
<211> 93
<212> PRT
<213> Homo sapiens

<400> 22
Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
1               5                   10                  15      


His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
            20                  25                  30          


Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
        35                  40                  45              


Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
    50                  55                  60                  


Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
65                  70                  75                  80  


Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                85                  90              


<210> 23
<211> 114
<212> PRT
<213> Homo sapiens

<400> 23
Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210> 24
<211> 202
<212> PRT
<213> Homo sapiens

<400> 24
Met Ser Ser Val Glu Lys Glu Thr Lys Thr Gln Cys Val Arg Ile Ala 
1               5                   10                  15      


Thr Lys Ala Ala Ala Thr Glu Glu Pro Glu Val Ile Pro Asp Pro Ala 
            20                  25                  30          


Lys Gln Thr Asp Arg Val Val Lys Ile Ala Gly Ile Ser Ala Gly Ile 
        35                  40                  45              


Leu Val Phe Ile Leu Leu Leu Leu Val Val Ile Leu Ile Val Lys Lys 
    50                  55                  60                  


Arg Arg Ser Tyr Tyr Ser Tyr Ser Tyr Tyr Leu Lys Leu Ala Lys Lys 
65                  70                  75                  80  


Arg Lys Asp Ala Met Gly Asn Thr Arg Gln Glu Met Thr His Met Val 
                85                  90                  95      


Asn Ala Met Asp Arg Ser Tyr Ala Asp Gln Ser Thr Leu His Ala Glu 
            100                 105                 110         


Asp Pro Leu Ser Ile Thr Phe Met Asp Gln His Asn Phe Ser Pro Arg 
        115                 120                 125             


Leu Pro Asn Asp Pro Leu Val Pro Thr Ala Val Leu Asp Glu Asn His 
    130                 135                 140                 


Ser Ala Thr Ala Glu Ser Ser Arg Leu Leu Asp Val Pro Arg Tyr Leu 
145                 150                 155                 160 


Cys Glu Gly Thr Glu Ser Pro Tyr Gln Thr Gly Gln Leu His Pro Ala 
                165                 170                 175     


Ile Arg Val Ala Asp Leu Leu Gln His Ile Asn Leu Met Lys Thr Ser 
            180                 185                 190         


Asp Ser Tyr Gly Phe Lys Glu Glu Tyr Glu 
        195                 200         


<210> 25
<211> 484
<212> PRT
<213> Homo sapiens

<400> 25
Met Ser Arg Ser Thr Gln Glu Leu Leu Gly Tyr His Cys Arg Leu Gln 
1               5                   10                  15      


Asp Lys Leu Gln Glu Gln Glu Gly Ser Leu Ala Ala Glu Gly Arg His 
            20                  25                  30          


Ser Leu Ala Ser Ala Ala Asp His Met Lys Val Val Pro Ser Leu Leu 
        35                  40                  45              


Leu Ser Val Leu Leu Ala Gln Val Trp Leu Val Pro Gly Leu Ala Pro 
    50                  55                  60                  


Ser Pro Gln Ser Pro Glu Thr Pro Ala Pro Gln Asn Gln Thr Ser Arg 
65                  70                  75                  80  


Val Val Gln Ala Pro Lys Glu Glu Glu Glu Asp Glu Gln Glu Ala Ser 
                85                  90                  95      


Glu Glu Lys Ala Ser Glu Glu Glu Lys Ala Trp Leu Met Ala Ser Arg 
            100                 105                 110         


Gln Gln Leu Ala Lys Glu Thr Ser Asn Phe Gly Phe Ser Leu Leu Arg 
        115                 120                 125             


Lys Ile Ser Met Arg His Asp Gly Asn Met Val Phe Ser Pro Phe Gly 
    130                 135                 140                 


Met Ser Leu Ala Met Thr Gly Leu Met Leu Gly Ala Thr Gly Pro Thr 
145                 150                 155                 160 


Glu Thr Gln Ile Lys Arg Gly Leu His Leu Gln Ala Leu Lys Pro Thr 
                165                 170                 175     


Lys Pro Gly Leu Leu Pro Ser Leu Phe Lys Gly Leu Arg Glu Thr Leu 
            180                 185                 190         


Ser Arg Asn Leu Glu Leu Gly Leu Thr Gln Gly Ser Phe Ala Phe Ile 
        195                 200                 205             


His Lys Asp Phe Asp Val Lys Glu Thr Phe Phe Asn Leu Ser Lys Arg 
    210                 215                 220                 


Tyr Phe Asp Thr Glu Cys Val Pro Met Asn Phe Arg Asn Ala Ser Gln 
225                 230                 235                 240 


Ala Lys Arg Leu Met Asn His Tyr Ile Asn Lys Glu Thr Arg Gly Lys 
                245                 250                 255     


Ile Pro Lys Leu Phe Asp Glu Ile Asn Pro Glu Thr Lys Leu Ile Leu 
            260                 265                 270         


Val Asp Tyr Ile Leu Phe Lys Gly Lys Trp Leu Thr Pro Phe Asp Pro 
        275                 280                 285             


Val Phe Thr Glu Val Asp Thr Phe His Leu Asp Lys Tyr Lys Thr Ile 
    290                 295                 300                 


Lys Val Pro Met Met Tyr Gly Ala Gly Lys Phe Ala Ser Thr Phe Asp 
305                 310                 315                 320 


Lys Asn Phe Arg Cys His Val Leu Lys Leu Pro Tyr Gln Gly Asn Ala 
                325                 330                 335     


Thr Met Leu Val Val Leu Met Glu Lys Met Gly Asp His Leu Ala Leu 
            340                 345                 350         


Glu Asp Tyr Leu Thr Thr Asp Leu Val Glu Thr Trp Leu Arg Asn Met 
        355                 360                 365             


Lys Thr Arg Asn Met Glu Val Phe Phe Pro Lys Phe Lys Leu Asp Gln 
    370                 375                 380                 


Lys Tyr Glu Met His Glu Leu Leu Arg Gln Met Gly Ile Arg Arg Ile 
385                 390                 395                 400 


Phe Ser Pro Phe Ala Asp Leu Ser Glu Leu Ser Ala Thr Gly Arg Asn 
                405                 410                 415     


Leu Gln Val Ser Arg Val Leu Gln Arg Thr Val Ile Glu Val Asp Glu 
            420                 425                 430         


Arg Gly Thr Glu Ala Val Ala Gly Ile Leu Ser Glu Ile Thr Ala Tyr 
        435                 440                 445             


Ser Met Pro Pro Val Ile Lys Val Asp Arg Pro Phe His Phe Met Ile 
    450                 455                 460                 


Tyr Glu Glu Thr Ser Gly Met Leu Leu Phe Leu Gly Arg Val Val Asn 
465                 470                 475                 480 


Pro Thr Leu Leu 
                


<210> 26
<211> 228
<212> PRT
<213> Homo sapiens

<400> 26
Met Pro Gly Ala Gly Asp Gly Gly Lys Ala Pro Ala Arg Trp Leu Gly 
1               5                   10                  15      


Thr Gly Leu Leu Gly Leu Phe Leu Leu Pro Val Thr Leu Ser Leu Glu 
            20                  25                  30          


Val Ser Val Gly Lys Ala Thr Asp Ile Tyr Ala Val Asn Gly Thr Glu 
        35                  40                  45              


Ile Leu Leu Pro Cys Thr Phe Ser Ser Cys Phe Gly Phe Glu Asp Leu 
    50                  55                  60                  


His Phe Arg Trp Thr Tyr Asn Ser Ser Asp Ala Phe Lys Ile Leu Ile 
65                  70                  75                  80  


Glu Gly Thr Val Lys Asn Glu Lys Ser Asp Pro Lys Val Thr Leu Lys 
                85                  90                  95      


Asp Asp Asp Arg Ile Thr Leu Val Gly Ser Thr Lys Glu Lys Met Asn 
            100                 105                 110         


Asn Ile Ser Ile Val Leu Arg Asp Leu Glu Phe Ser Asp Thr Gly Lys 
        115                 120                 125             


Tyr Thr Cys His Val Lys Asn Pro Lys Glu Asn Asn Leu Gln His His 
    130                 135                 140                 


Ala Thr Ile Phe Leu Gln Val Val Asp Arg Leu Glu Glu Val Asp Asn 
145                 150                 155                 160 


Thr Val Thr Leu Ile Ile Leu Ala Val Val Gly Gly Val Ile Gly Leu 
                165                 170                 175     


Leu Ile Leu Ile Leu Leu Ile Lys Lys Leu Ile Ile Phe Ile Leu Lys 
            180                 185                 190         


Lys Thr Arg Glu Lys Lys Lys Glu Cys Leu Val Ser Ser Ser Gly Asn 
        195                 200                 205             


Asp Asn Thr Glu Asn Gly Leu Pro Gly Ser Lys Ala Glu Glu Lys Pro 
    210                 215                 220                 


Pro Ser Lys Val 
225             


<210> 27
<211> 2214
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe 
1               5                   10                  15      


Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr 
            20                  25                  30          


Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe 
        35                  40                  45              


Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly 
    50                  55                  60                  


Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys 
65                  70                  75                  80  


Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val 
                85                  90                  95      


Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu 
            100                 105                 110         


Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala 
        115                 120                 125             


Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser 
    130                 135                 140                 


Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser 
145                 150                 155                 160 


Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg 
                165                 170                 175     


Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp 
            180                 185                 190         


Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp 
        195                 200                 205             


Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr 
225                 230                 235                 240 


Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp 
                245                 250                 255     


Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser 
            260                 265                 270         


Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu 
        275                 280                 285             


Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp 
    290                 295                 300                 


Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln 
305                 310                 315                 320 


Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg 
                325                 330                 335     


Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala 
            340                 345                 350         


Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn 
        355                 360                 365             


Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu 
    370                 375                 380                 


Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp 
385                 390                 395                 400 


Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg 
                405                 410                 415     


Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser 
            420                 425                 430         


Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly 
        435                 440                 445             


Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys 
    450                 455                 460                 


Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg 
465                 470                 475                 480 


Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser 
                485                 490                 495     


Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys 
            500                 505                 510         


Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala 
        515                 520                 525             


Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp 
    530                 535                 540                 


His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu 
545                 550                 555                 560 


Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe 
                565                 570                 575     


Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu 
            580                 585                 590         


Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His 
        595                 600                 605             


Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro 
    610                 615                 620                 


Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly 
625                 630                 635                 640 


Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro 
                645                 650                 655     


His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val 
            660                 665                 670         


Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe 
        675                 680                 685             


Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu 
    690                 695                 700                 


Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser 
705                 710                 715                 720 


Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys 
                725                 730                 735     


Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys 
            740                 745                 750         


Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser 
        755                 760                 765             


Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu 
    770                 775                 780                 


Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn 
785                 790                 795                 800 


Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys 
                805                 810                 815     


Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu 
            820                 825                 830         


Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp 
        835                 840                 845             


Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp 
    850                 855                 860                 


Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala 
865                 870                 875                 880 


Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly 
                885                 890                 895     


Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala 
            900                 905                 910         


Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val 
        915                 920                 925             


Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu 
    930                 935                 940                 


Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu 
945                 950                 955                 960 


Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp 
                965                 970                 975     


Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser 
            980                 985                 990         


Gln Met Glu Ile Leu Ala Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys 
        995                 1000                 1005             


Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro 
    1010                 1015                 1020             


Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg 
    1025                 1030                 1035             


Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser 
    1040                 1045                 1050             


Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn 
    1055                 1060                 1065             


Asn Thr  Cys Val Lys Glu Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr 
    1070                 1075                 1080             


Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp 
    1085                 1090                 1095             


Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro 
    1100                 1105                 1110             


Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser 
    1115                 1120                 1125             


Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp 
    1130                 1135                 1140             


Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys Glu Met  His Gln Cys 
    1145                 1150                 1155             


Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser 
    1160                 1165                 1170             


Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp 
    1175                 1180                 1185             


Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn 
    1190                 1195                 1200             


Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys 
    1205                 1210                 1215             


Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val 
    1220                 1225                 1230             


Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr 
    1235                 1240                 1245             


Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser 
    1250                 1255                 1260             


Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro Leu Cys  Thr His Phe 
    1265                 1270                 1275             


Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser 
    1280                 1285                 1290             


Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu 
    1295                 1300                 1305             


Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys 
    1310                 1315                 1320             


Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile 
    1325                 1330                 1335             


Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr 
    1340                 1345                 1350             


Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys 
    1355                 1360                 1365             


Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro 
    1370                 1375                 1380             


Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser 
    1385                 1390                 1395             


Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr 
    1400                 1405                 1410             


Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser 
    1415                 1420                 1425             


Gly Thr  Cys Val Met Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp 
    1430                 1435                 1440             


Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn 
    1445                 1450                 1455             


Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg 
    1460                 1465                 1470             


Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp 
    1475                 1480                 1485             


Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu 
    1490                 1495                 1500             


Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr Cys Met  Ser Arg Glu 
    1505                 1510                 1515             


Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile Val Leu  Ser Glu Arg 
    1520                 1525                 1530             


Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu Ser Asp  Glu Lys Ala 
    1535                 1540                 1545             


Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val Gln Asn  Leu Gln Trp 
    1550                 1555                 1560             


Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu Thr Trp  Met Arg Pro 
    1565                 1570                 1575             


Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr Asn Val  Tyr Tyr Arg 
    1580                 1585                 1590             


Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu Glu Thr  His Ser Asn 
    1595                 1600                 1605             


Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys Pro Asp  Thr Thr Tyr 
    1610                 1615                 1620             


Gln Val  Lys Val Gln Val Gln  Cys Leu Ser Lys Ala  His Asn Thr 
    1625                 1630                 1635             


Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu Gly Leu  Pro Asp Ala 
    1640                 1645                 1650             


Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg Glu Ala  Glu Gly Val 
    1655                 1660                 1665             


Ile Val  Gly His Trp Ala Pro  Pro Ile His Thr His  Gly Leu Ile 
    1670                 1675                 1680             


Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser Gly Ser  Lys Met Trp 
    1685                 1690                 1695             


Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr Glu Ile  Lys Asn Leu 
    1700                 1705                 1710             


Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val Ala Ala  Val Thr Ser 
    1715                 1720                 1725             


Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys Ser Ile  Thr Thr Ile 
    1730                 1735                 1740             


Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile His Ile  Asp Ser Tyr 
    1745                 1750                 1755             


Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr Met Glu  Ser Asp Ile 
    1760                 1765                 1770             


Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe Trp Ala  Phe Asp Thr 
    1775                 1780                 1785             


His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe Arg Gly  Ser Ile Leu 
    1790                 1795                 1800             


Ser His  Lys Val Gly Asn Leu  Thr Ala His Thr Ser  Tyr Glu Ile 
    1805                 1810                 1815             


Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp Ser Pro  Leu Ala Phe 
    1820                 1825                 1830             


Glu His  Val Met Thr Arg Gly  Val Arg Pro Pro Ala  Pro Ser Leu 
    1835                 1840                 1845             


Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val Glu Cys  Thr Trp Thr 
    1850                 1855                 1860             


Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe 
    1865                 1870                 1875             


Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His 
    1880                 1885                 1890             


Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu 
    1895                 1900                 1905             


Val Arg  Val Val Val Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val 
    1910                 1915                 1920             


Val Val  Lys Met Ile Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu 
    1925                 1930                 1935             


His Val  Val His Thr Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu 
    1940                 1945                 1950             


Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu Leu Tyr  Ala Ile Ala 
    1955                 1960                 1965             


Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys 
    1970                 1975                 1980             


Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro 
    1985                 1990                 1995             


Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys 
    2000                 2005                 2010             


Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp 
    2015                 2020                 2025             


Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His Val Leu  Leu Phe Trp 
    2030                 2035                 2040             


Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly 
    2045                 2050                 2055             


Tyr Glu  Ile His Met Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr 
    2060                 2065                 2070             


Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys 
    2075                 2080                 2085             


Met Gly  His Asn Tyr Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe 
    2090                 2095                 2100             


Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu 
    2105                 2110                 2115             


Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser 
    2120                 2125                 2130             


Thr Asp  Val Ala Ala Val Val  Val Pro Ile Leu Phe  Leu Ile Leu 
    2135                 2140                 2145             


Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu Tyr Thr  Lys His Arg 
    2150                 2155                 2160             


Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala Asn Ser  His Tyr Ser 
    2165                 2170                 2175             


Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser Gly Asp  Asp Leu Gly 
    2180                 2185                 2190             


Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr Gly Phe  Ser Asp Asp 
    2195                 2200                 2205             


Val Pro  Met Val Ile Ala 
    2210                 


<210> 28
<211> 168
<212> PRT
<213> Homo sapiens

<400> 28
Met Arg Ser Phe Leu Leu Val Trp Lys Leu Phe Arg Arg Lys Asp Met 
1               5                   10                  15      


Lys His Gln Arg Lys Thr Ala Thr Glu Phe Lys Thr Thr Glu Glu Gly 
            20                  25                  30          


Glu Thr Arg Gln Asp Gly Lys Asp Gly Ser Leu Thr Tyr Arg Ala Asp 
        35                  40                  45              


Thr Cys Ser Pro Cys Pro Glu Ala Gly Gly Pro Pro Ser Ser Ser Ile 
    50                  55                  60                  


Ala Ser Gly Ser Ser Ile Ser Val Gly Asn Ser Pro Ser His Ser His 
65                  70                  75                  80  


Ser His Thr Ser Arg Arg Cys Gly Gly Ser Ser Arg Ser Arg Glu Cys 
                85                  90                  95      


Cys Ser Ser Leu His Ser Ser Arg Gly Ser Arg Gly Ser Ser Trp Ser 
            100                 105                 110         


Ser Ser Pro Pro Gly Ser Thr Cys Arg Trp Cys Ser Cys His Ser His 
        115                 120                 125             


His His Ser His His Arg Ser His His Arg Ser His His Cys Ser His 
    130                 135                 140                 


His His Ser His His His Ser Gly His His Ser His His Asn Phe His 
145                 150                 155                 160 


Asn His Ser Asn Pro Trp Cys Gln 
                165             


<210> 29
<211> 527
<212> PRT
<213> Homo sapiens

<400> 29
Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210> 30
<211> 175
<212> PRT
<213> Homo sapiens

<400> 30
Met Asn Ile His Ile His Thr Cys Met His Ile Tyr Thr His Ala His 
1               5                   10                  15      


Thr His Ala His Ile His Thr Cys Ile His Thr His Thr His Met His 
            20                  25                  30          


Thr His Thr Leu Thr Tyr Thr His Ile His Met His Thr His Thr Gln 
        35                  40                  45              


Thr His Ile Tyr Thr Gln Ala His Ile His Ser Cys Thr Gln Ile Asn 
    50                  55                  60                  


Ile Tyr Thr Tyr Ala Tyr Thr Leu Thr Cys Thr Gln Thr His Thr His 
65                  70                  75                  80  


Ile Cys Thr His Ala His Thr Leu Thr Tyr Thr His Ile His Thr Cys 
                85                  90                  95      


Thr Tyr Lys Arg Thr Tyr Ile Gln Gly His Ile His Thr His Met His 
            100                 105                 110         


Thr Tyr Thr Cys Thr Cys Thr His Thr His Lys His Ile His Ala His 
        115                 120                 125             


Ile His Ile His Thr His Thr His Ile Tyr Thr His Thr Asp Ala Tyr 
    130                 135                 140                 


Thr His Met Asp Thr Tyr Thr His Thr Tyr Pro His Thr His Ile Cys 
145                 150                 155                 160 


Ile His Ser His Thr His Ala His Thr Tyr Thr His Ile Arg Thr 
                165                 170                 175 


<210> 31
<211> 226
<212> PRT
<213> Homo sapiens

<400> 31
Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
            20                  25                  30          


His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
        35                  40                  45              


Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ser Tyr Cys Gly Leu Thr Gly Gln Tyr Ile 
65                  70                  75                  80  


Glu Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val Ile 
                85                  90                  95      


Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn 
            100                 105                 110         


Ser Glu Ile Leu Pro Thr Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
        115                 120                 125             


Val Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
    130                 135                 140                 


Glu Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser 
145                 150                 155                 160 


Glu Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val 
                165                 170                 175     


His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
            180                 185                 190         


Ile Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn Val Lys 
        195                 200                 205             


Met Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Val Lys 
    210                 215                 220                 


Arg Lys 
225     


<210> 32
<211> 655
<212> PRT
<213> Homo sapiens

<400> 32
Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu 
1               5                   10                  15      


Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly 
            20                  25                  30          


Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn 
        35                  40                  45              


Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr 
    50                  55                  60                  


Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro 
                85                  90                  95      


Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe 
            100                 105                 110         


Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala 
        115                 120                 125             


His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala 
    130                 135                 140                 


Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala 
145                 150                 155                 160 


Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser 
                165                 170                 175     


Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe 
            180                 185                 190         


Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr 
        195                 200                 205             


Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His 
    210                 215                 220                 


Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr 
225                 230                 235                 240 


Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys 
                245                 250                 255     


His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly 
            260                 265                 270         


Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu 
        275                 280                 285             


Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly 
    290                 295                 300                 


Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His 
305                 310                 315                 320 


Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala 
                325                 330                 335     


Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val 
            340                 345                 350         


Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Glu 
        355                 360                 365             


Ser Leu Thr Arg Val Gln Leu Ser Pro Asp Leu Leu Ala Thr Leu Pro 
    370                 375                 380                 


Glu Pro Ala Ser Pro Gly Arg Gln Ala Cys Gly Arg Arg His Lys Lys 
385                 390                 395                 400 


Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly Ser Ser Ser Leu Pro 
                405                 410                 415     


Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile Gly Asp Ser Phe Cys 
            420                 425                 430         


Ala Gly Ser Leu Val His Thr Cys Trp Val Val Ser Ala Ala His Cys 
        435                 440                 445             


Phe Ser His Ser Pro Pro Arg Asp Ser Val Ser Val Val Leu Gly Gln 
    450                 455                 460                 


His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly Ile Glu 
465                 470                 475                 480 


Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp His 
                485                 490                 495     


Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys Ala Thr 
            500                 505                 510         


Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly Ser Thr 
        515                 520                 525             


Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His Leu Asp 
    530                 535                 540                 


Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu Val Pro 
545                 550                 555                 560 


Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly Ala Asp 
                565                 570                 575     


Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys Ser Asp 
            580                 585                 590         


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys Asn Gly 
        595                 600                 605             


Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys Gly Arg 
    610                 615                 620                 


Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val Asp Trp 
625                 630                 635                 640 


Ile Asn Asp Arg Ile Arg Pro Pro Arg Arg Leu Val Ala Pro Ser 
                645                 650                 655 


<210> 33
<211> 697
<212> PRT
<213> Homo sapiens

<400> 33
Met Leu Arg Gly Pro Cys Ser Pro Leu Asn Asp Phe Gln Val Leu Arg 
1               5                   10                  15      


Gly Thr Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp 
            20                  25                  30          


Gln Glu Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro 
        35                  40                  45              


Leu Met Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys 
    50                  55                  60                  


Gln Leu Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg 
65                  70                  75                  80  


Ser Gly Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys 
                85                  90                  95      


Ile Met Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val 
            100                 105                 110         


Gly Gly Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His 
        115                 120                 125             


Lys Tyr Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg 
    130                 135                 140                 


Asn Pro Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro 
145                 150                 155                 160 


Ala Val Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala 
                165                 170                 175     


Cys Val Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr 
            180                 185                 190         


Glu Ser Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln 
        195                 200                 205             


His Pro Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn 
    210                 215                 220                 


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr 
225                 230                 235                 240 


Asp Pro Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser 
                245                 250                 255     


Glu Ala Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly 
            260                 265                 270         


Lys Gly Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val 
        275                 280                 285             


Pro Cys Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr 
    290                 295                 300                 


Pro Glu Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn 
305                 310                 315                 320 


Pro Asp Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met 
                325                 330                 335     


Arg Ala Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg 
            340                 345                 350         


Pro Gln Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val 
        355                 360                 365             


Ser Lys Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr 
    370                 375                 380                 


Pro His Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu 
385                 390                 395                 400 


Glu Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp 
                405                 410                 415     


Cys Tyr Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg 
            420                 425                 430         


Arg Cys Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln 
        435                 440                 445             


Val Gln Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg 
    450                 455                 460                 


Arg Ser Lys Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp 
465                 470                 475                 480 


Thr Val Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser 
                485                 490                 495     


Leu Val Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser 
            500                 505                 510         


Cys His Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe 
        515                 520                 525             


Gln Asn Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala 
    530                 535                 540                 


Lys Met Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu 
545                 550                 555                 560 


Glu Arg Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro 
                565                 570                 575     


Pro Glu Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly 
            580                 585                 590         


Trp Gly Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala 
        595                 600                 605             


Leu Leu Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly 
    610                 615                 620                 


Arg Val Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val 
625                 630                 635                 640 


Gly Ala Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His 
                645                 650                 655     


Asn Cys Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala 
            660                 665                 670         


Arg Ser Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp 
        675                 680                 685             


Trp Ile His Lys Val Met Arg Leu Gly 
    690                 695         


<210> 34
<211> 240
<212> PRT
<213> Homo sapiens

<400> 34
Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210> 35
<211> 88
<212> PRT
<213> Homo sapiens

<400> 35
Met Phe Thr Leu Arg Leu Phe Ala Gly Lys Ala Cys Trp Pro Val Leu 
1               5                   10                  15      


Tyr Thr Met Leu Lys Glu Val Thr Cys Asp Val Cys Val Cys Val Arg 
            20                  25                  30          


Ala Arg Ala Cys Thr Cys Met Cys Met Cys Val Cys Glu Cys Met Asp 
        35                  40                  45              


Val Cys Val Arg Leu Tyr Thr Met Leu Lys Glu Val Thr Cys Asp Met 
    50                  55                  60                  


Cys Val Cys Ala Arg Thr Cys Val His Val Cys Val Ser Ala Trp Met 
65                  70                  75                  80  


Cys Val Cys Thr Cys Thr Gln Cys 
                85              


<210> 36
<211> 1439
<212> PRT
<213> Homo sapiens

<400> 36
Met Asp Thr Thr Ala Ala Ala Ala Leu Pro Ala Phe Val Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Pro Trp Pro Leu Leu Gly Ser Ala Gln Gly Gln Phe Ser 
            20                  25                  30          


Ala Gly Gly Cys Thr Phe Asp Asp Gly Pro Gly Ala Cys Asp Tyr His 
        35                  40                  45              


Gln Asp Leu Tyr Asp Asp Phe Glu Trp Val His Val Ser Ala Gln Glu 
    50                  55                  60                  


Pro His Tyr Leu Pro Pro Glu Met Pro Gln Gly Ser Tyr Met Ile Val 
65                  70                  75                  80  


Asp Ser Ser Asp His Asp Pro Gly Glu Lys Ala Arg Leu Gln Leu Pro 
                85                  90                  95      


Thr Met Lys Glu Asn Asp Thr His Cys Ile Asp Phe Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Ser Gln Lys Gly Leu Asn Pro Gly Thr Leu Asn Ile Leu Val Arg 
        115                 120                 125             


Val Asn Lys Gly Pro Leu Ala Asn Pro Ile Trp Asn Val Thr Gly Phe 
    130                 135                 140                 


Thr Gly Arg Asp Trp Leu Arg Ala Glu Leu Ala Val Ser Thr Phe Trp 
145                 150                 155                 160 


Pro Asn Glu Tyr Gln Val Ile Phe Glu Ala Glu Val Ser Gly Gly Arg 
                165                 170                 175     


Ser Gly Tyr Ile Ala Ile Asp Asp Ile Gln Val Leu Ser Tyr Pro Cys 
            180                 185                 190         


Asp Lys Ser Pro His Phe Leu Arg Leu Gly Asp Val Glu Val Asn Ala 
        195                 200                 205             


Gly Gln Asn Ala Thr Phe Gln Cys Ile Ala Thr Gly Arg Asp Ala Val 
    210                 215                 220                 


His Asn Lys Leu Trp Leu Gln Arg Arg Asn Gly Glu Asp Ile Pro Val 
225                 230                 235                 240 


Ala Gln Thr Lys Asn Ile Asn His Arg Arg Phe Ala Ala Ser Phe Arg 
                245                 250                 255     


Leu Gln Glu Val Thr Lys Thr Asp Gln Asp Leu Tyr Arg Cys Val Thr 
            260                 265                 270         


Gln Ser Glu Arg Gly Ser Gly Val Ser Asn Phe Ala Gln Leu Ile Val 
        275                 280                 285             


Arg Glu Pro Pro Arg Pro Ile Ala Pro Pro Gln Leu Leu Gly Val Gly 
    290                 295                 300                 


Pro Thr Tyr Leu Leu Ile Gln Leu Asn Ala Asn Ser Ile Ile Gly Asp 
305                 310                 315                 320 


Gly Pro Ile Ile Leu Lys Glu Val Glu Tyr Arg Met Thr Ser Gly Ser 
                325                 330                 335     


Trp Thr Glu Thr His Ala Val Asn Ala Pro Thr Tyr Lys Leu Trp His 
            340                 345                 350         


Leu Asp Pro Asp Thr Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro 
        355                 360                 365             


Gly Glu Gly Gly Thr Gly Leu Pro Gly Pro Pro Leu Ile Thr Arg Thr 
    370                 375                 380                 


Lys Cys Ala Glu Pro Met Arg Thr Pro Lys Thr Leu Lys Ile Ala Glu 
385                 390                 395                 400 


Ile Gln Ala Arg Arg Ile Ala Val Asp Trp Glu Ser Leu Gly Tyr Asn 
                405                 410                 415     


Ile Thr Arg Cys His Thr Phe Asn Val Thr Ile Cys Tyr His Tyr Phe 
            420                 425                 430         


Arg Gly His Asn Glu Ser Lys Ala Asp Cys Leu Asp Met Asp Pro Lys 
        435                 440                 445             


Ala Pro Gln His Val Val Asn His Leu Pro Pro Tyr Thr Asn Val Ser 
    450                 455                 460                 


Leu Lys Met Ile Leu Thr Asn Pro Glu Gly Arg Lys Glu Ser Glu Glu 
465                 470                 475                 480 


Thr Ile Ile Gln Thr Asp Glu Asp Val Pro Gly Pro Val Pro Val Lys 
                485                 490                 495     


Ser Leu Gln Gly Thr Ser Phe Glu Asn Lys Ile Phe Leu Asn Trp Lys 
            500                 505                 510         


Glu Pro Leu Asp Pro Asn Gly Ile Ile Thr Gln Tyr Glu Ile Ser Tyr 
        515                 520                 525             


Ser Ser Ile Arg Ser Phe Asp Pro Ala Val Pro Val Ala Gly Pro Pro 
    530                 535                 540                 


Gln Thr Val Ser Asn Leu Trp Asn Ser Thr His His Val Phe Met His 
545                 550                 555                 560 


Leu His Pro Gly Thr Thr Tyr Gln Phe Phe Ile Arg Ala Ser Thr Val 
                565                 570                 575     


Lys Gly Phe Gly Pro Ala Thr Ala Ile Asn Val Thr Thr Asn Ile Ser 
            580                 585                 590         


Ala Pro Thr Leu Pro Asp Tyr Glu Gly Val Asp Ala Ser Leu Asn Glu 
        595                 600                 605             


Thr Ala Thr Thr Ile Thr Val Leu Leu Arg Pro Ala Gln Ala Lys Gly 
    610                 615                 620                 


Ala Pro Ile Ser Ala Tyr Gln Ile Val Val Glu Glu Leu His Pro His 
625                 630                 635                 640 


Arg Thr Lys Arg Glu Ala Gly Ala Met Glu Cys Tyr Gln Val Pro Val 
                645                 650                 655     


Thr Tyr Gln Asn Ala Met Ser Gly Gly Ala Pro Tyr Tyr Phe Ala Ala 
            660                 665                 670         


Glu Leu Pro Pro Gly Asn Leu Pro Glu Pro Ala Pro Phe Thr Val Gly 
        675                 680                 685             


Asp Asn Arg Thr Tyr Gln Gly Phe Trp Asn Pro Pro Leu Ala Pro Arg 
    690                 695                 700                 


Lys Gly Tyr Asn Ile Tyr Phe Gln Ala Met Ser Ser Val Glu Lys Glu 
705                 710                 715                 720 


Thr Lys Thr Gln Cys Val Arg Ile Ala Thr Lys Ala Ala Thr Glu Glu 
                725                 730                 735     


Pro Glu Val Ile Pro Asp Pro Ala Lys Gln Thr Asp Arg Val Val Lys 
            740                 745                 750         


Ile Ala Gly Ile Ser Ala Gly Ile Leu Val Phe Ile Leu Leu Leu Leu 
        755                 760                 765             


Val Val Ile Leu Ile Val Lys Lys Ser Lys Leu Ala Lys Lys Arg Lys 
    770                 775                 780                 


Asp Ala Met Gly Asn Thr Arg Gln Glu Met Thr His Met Val Asn Ala 
785                 790                 795                 800 


Met Asp Arg Ser Tyr Ala Asp Gln Ser Thr Leu His Ala Glu Asp Pro 
                805                 810                 815     


Leu Ser Ile Thr Phe Met Asp Gln His Asn Phe Ser Pro Arg Tyr Glu 
            820                 825                 830         


Asn His Ser Ala Thr Ala Glu Ser Ser Arg Leu Leu Asp Val Pro Arg 
        835                 840                 845             


Tyr Leu Cys Glu Gly Thr Glu Ser Pro Tyr Gln Thr Gly Gln Leu His 
    850                 855                 860                 


Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Asn Leu Met Lys 
865                 870                 875                 880 


Thr Ser Asp Ser Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu 
                885                 890                 895     


Gly Gln Ser Ala Ser Trp Asp Val Ala Lys Lys Asp Gln Asn Arg Ala 
            900                 905                 910         


Lys Asn Arg Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val Ile 
        915                 920                 925             


Leu Gln Pro Val Glu Asp Asp Pro Ser Ser Asp Tyr Ile Asn Ala Asn 
    930                 935                 940                 


Tyr Ile Asp Gly Tyr Gln Arg Pro Ser His Tyr Ile Ala Thr Gln Gly 
945                 950                 955                 960 


Pro Val His Glu Thr Val Tyr Asp Phe Trp Arg Met Ile Trp Gln Glu 
                965                 970                 975     


Gln Ser Ala Cys Ile Val Met Val Thr Asn Leu Val Glu Val Gly Arg 
            980                 985                 990         


Val Lys Cys Tyr Lys Tyr Trp Pro  Asp Asp Thr Glu Val  Tyr Gly Asp 
        995                 1000                 1005             


Phe Lys  Val Thr Cys Val Glu  Met Glu Pro Leu Ala  Glu Tyr Val 
    1010                 1015                 1020             


Val Arg  Thr Phe Thr Leu Glu  Arg Arg Gly Tyr Asn  Glu Ile Arg 
    1025                 1030                 1035             


Glu Val  Lys Gln Phe His Phe  Thr Gly Trp Pro Asp  His Gly Val 
    1040                 1045                 1050             


Pro Tyr  His Ala Thr Gly Leu  Leu Ser Phe Ile Arg  Arg Val Lys 
    1055                 1060                 1065             


Leu Ser  Asn Pro Pro Ser Ala  Gly Pro Ile Val Val  His Cys Ser 
    1070                 1075                 1080             


Ala Gly  Ala Gly Arg Thr Gly  Cys Tyr Ile Val Ile  Asp Ile Met 
    1085                 1090                 1095             


Leu Asp  Met Ala Glu Arg Glu  Gly Val Val Asp Ile  Tyr Asn Cys 
    1100                 1105                 1110             


Val Lys  Ala Leu Arg Ser Arg  Arg Ile Asn Met Val  Gln Thr Glu 
    1115                 1120                 1125             


Glu Gln  Tyr Ile Phe Ile His  Asp Ala Ile Leu Glu  Ala Cys Leu 
    1130                 1135                 1140             


Cys Gly  Glu Thr Ala Ile Pro  Val Cys Glu Phe Lys  Ala Ala Tyr 
    1145                 1150                 1155             


Phe Asp  Met Ile Arg Ile Asp  Ser Gln Thr Asn Ser  Ser His Leu 
    1160                 1165                 1170             


Lys Asp  Glu Phe Gln Thr Leu  Asn Ser Val Thr Pro  Arg Leu Gln 
    1175                 1180                 1185             


Ala Glu  Asp Cys Ser Ile Ala  Cys Leu Pro Arg Asn  His Asp Lys 
    1190                 1195                 1200             


Asn Arg  Phe Met Asp Met Leu  Pro Pro Asp Arg Cys  Leu Pro Phe 
    1205                 1210                 1215             


Leu Ile  Thr Ile Asp Gly Glu  Ser Ser Asn Tyr Ile  Asn Ala Ala 
    1220                 1225                 1230             


Leu Met  Asp Ser Tyr Arg Gln  Pro Ala Ala Phe Ile  Val Thr Gln 
    1235                 1240                 1245             


Tyr Pro  Leu Pro Asn Thr Val  Lys Asp Phe Trp Arg  Leu Val Tyr 
    1250                 1255                 1260             


Asp Tyr  Gly Cys Thr Ser Ile  Val Met Leu Asn Glu  Val Asp Leu 
    1265                 1270                 1275             


Ser Gln  Gly Cys Pro Gln Tyr  Trp Pro Glu Glu Gly  Met Leu Arg 
    1280                 1285                 1290             


Tyr Gly  Pro Ile Gln Val Glu  Cys Met Ser Cys Ser  Met Asp Cys 
    1295                 1300                 1305             


Asp Val  Ile Asn Arg Ile Phe  Arg Ile Cys Asn Leu  Thr Arg Pro 
    1310                 1315                 1320             


Gln Glu  Gly Tyr Leu Met Val  Gln Gln Phe Gln Tyr  Leu Gly Trp 
    1325                 1330                 1335             


Ala Ser  His Arg Glu Val Pro  Gly Ser Lys Arg Ser  Phe Leu Lys 
    1340                 1345                 1350             


Leu Ile  Leu Gln Val Glu Lys  Trp Gln Glu Glu Cys  Glu Glu Gly 
    1355                 1360                 1365             


Glu Gly  Arg Thr Ile Ile His  Cys Leu Asn Gly Gly  Gly Arg Ser 
    1370                 1375                 1380             


Gly Met  Phe Cys Ala Ile Gly  Ile Val Val Glu Met  Val Lys Arg 
    1385                 1390                 1395             


Gln Asn  Val Val Asp Val Phe  His Ala Val Lys Thr  Leu Arg Asn 
    1400                 1405                 1410             


Ser Lys  Pro Asn Met Val Glu  Ala Pro Glu Gln Tyr  Arg Phe Cys 
    1415                 1420                 1425             


Tyr Asp  Val Ala Leu Glu Tyr  Leu Glu Ser Ser 
    1430                 1435                 


<210> 37
<211> 1272
<212> PRT
<213> Homo sapiens

<400> 37
Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr 
1               5                   10                  15      


Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp 
            20                  25                  30          


Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg 
        35                  40                  45              


Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu 
    50                  55                  60                  


Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala 
                85                  90                  95      


Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn 
            100                 105                 110         


Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln 
        115                 120                 125             


Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe 
    130                 135                 140                 


Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp 
145                 150                 155                 160 


Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His 
                165                 170                 175     


Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp 
            180                 185                 190         


Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro 
        195                 200                 205             


Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly 
    210                 215                 220                 


Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly 
225                 230                 235                 240 


Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly 
                245                 250                 255     


Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu 
            260                 265                 270         


Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr 
        275                 280                 285             


Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val 
    290                 295                 300                 


Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val 
305                 310                 315                 320 


Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn 
                325                 330                 335     


Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile 
            340                 345                 350         


Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met 
        355                 360                 365             


Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg 
    370                 375                 380                 


Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr 
385                 390                 395                 400 


Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn 
                405                 410                 415     


Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val 
            420                 425                 430         


Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser 
        435                 440                 445             


Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile 
    450                 455                 460                 


Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr 
465                 470                 475                 480 


Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu 
                485                 490                 495     


Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg 
            500                 505                 510         


Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr 
        515                 520                 525             


Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp 
    530                 535                 540                 


Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val 
545                 550                 555                 560 


Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp 
                565                 570                 575     


Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala 
            580                 585                 590         


Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu 
        595                 600                 605             


His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser 
    610                 615                 620                 


Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile 
625                 630                 635                 640 


Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala 
                645                 650                 655     


Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Val Trp Asn Thr Gly Ser 
            660                 665                 670         


Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys 
        675                 680                 685             


Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys 
    690                 695                 700                 


Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys 
705                 710                 715                 720 


His Trp Cys Asn Asp His Cys Val Pro Arg Asn His Ser Cys Ser Glu 
                725                 730                 735     


Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro 
            740                 745                 750         


Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp 
        755                 760                 765             


Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro 
    770                 775                 780                 


Glu Asn Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu 
785                 790                 795                 800 


Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys 
                805                 810                 815     


Arg Asn His Asn Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val 
            820                 825                 830         


Glu Phe Val Leu Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met 
        835                 840                 845             


Ser Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val 
    850                 855                 860                 


Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu 
865                 870                 875                 880 


Gln Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu 
                885                 890                 895     


Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro 
            900                 905                 910         


Leu Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln 
        915                 920                 925             


Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser 
    930                 935                 940                 


Gly Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp 
945                 950                 955                 960 


Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp 
                965                 970                 975     


Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr 
            980                 985                 990         


Cys Ser His Cys Leu Glu Gln Pro  Gly Cys Gly Trp Cys  Thr Asp Pro 
        995                 1000                 1005             


Ser Asn  Thr Gly Lys Gly Lys  Cys Ile Glu Gly Ser  Tyr Lys Gly 
    1010                 1015                 1020             


Pro Val  Lys Met Pro Ser Gln  Ala Pro Thr Gly Asn  Phe Tyr Pro 
    1025                 1030                 1035             


Gln Pro  Leu Leu Asn Ser Ser  Met Cys Leu Glu Asp  Ser Arg Tyr 
    1040                 1045                 1050             


Asn Trp  Ser Phe Ile His Cys  Pro Ala Cys Gln Cys  Asn Gly His 
    1055                 1060                 1065             


Ser Lys  Cys Ile Asn Gln Ser  Ile Cys Glu Lys Cys  Glu Asn Leu 
    1070                 1075                 1080             


Thr Thr  Gly Lys His Cys Glu  Thr Cys Ile Ser Gly  Phe Tyr Gly 
    1085                 1090                 1095             


Asp Pro  Thr Asn Gly Gly Lys  Cys Gln Pro Cys Lys  Cys Asn Gly 
    1100                 1105                 1110             


His Ala  Ser Leu Cys Asn Thr  Asn Thr Gly Lys Cys  Phe Cys Thr 
    1115                 1120                 1125             


Thr Lys  Gly Val Lys Gly Asp  Glu Cys Gln Leu Cys  Glu Val Glu 
    1130                 1135                 1140             


Asn Arg  Tyr Gln Gly Asn Pro  Leu Arg Gly Thr Cys  Tyr Tyr Thr 
    1145                 1150                 1155             


Leu Leu  Ile Asp Tyr Gln Phe  Thr Phe Ser Leu Ser  Gln Glu Asp 
    1160                 1165                 1170             


Asp Arg  Tyr Tyr Thr Ala Ile  Asn Phe Val Ala Thr  Pro Asp Glu 
    1175                 1180                 1185             


Gln Asn  Arg Asp Leu Asp Met  Phe Ile Asn Ala Ser  Lys Asn Phe 
    1190                 1195                 1200             


Asn Leu  Asn Ile Thr Trp Ala  Ala Ser Phe Ser Ala  Gly Thr Gln 
    1205                 1210                 1215             


Ala Gly  Glu Glu Met Pro Val  Val Ser Lys Thr Asn  Ile Lys Glu 
    1220                 1225                 1230             


Tyr Lys  Asp Ser Phe Ser Asn  Glu Lys Phe Asp Phe  Arg Asn His 
    1235                 1240                 1245             


Pro Asn  Ile Thr Phe Phe Val  Tyr Val Ser Asn Phe  Thr Trp Pro 
    1250                 1255                 1260             


Ile Lys  Ile Gln Val Gln Thr  Glu Gln 
    1265                 1270         


<210> 38
<211> 289
<212> PRT
<213> Homo sapiens

<400> 38
Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr Gln Asp 
1               5                   10                  15      


Asp Asp Thr Asp Ala Val Glu Ile Ala Ile Asp Asn Thr Ala Phe Met 
            20                  25                  30          


Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile Asp Lys 
        35                  40                  45              


Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile Ile Leu 
    50                  55                  60                  


Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu Gln Leu 
65                  70                  75                  80  


Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys Leu Lys 
                85                  90                  95      


Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser Ala Asp 
            100                 105                 110         


Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys Phe Val 
        115                 120                 125             


Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg Glu Arg 
    130                 135                 140                 


Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys Lys Thr 
145                 150                 155                 160 


Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro Ala Ile 
                165                 170                 175     


Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala Leu Ser 
            180                 185                 190         


Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile 
        195                 200                 205             


Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn 
    210                 215                 220                 


Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val 
225                 230                 235                 240 


Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Lys Ala Val Lys Tyr 
                245                 250                 255     


Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile Ile Ile Val Leu Val Val 
            260                 265                 270         


Val Leu Leu Gly Ile Leu Ala Leu Ile Ile Gly Leu Ser Val Gly Leu 
        275                 280                 285             


Asn 
    


<210> 39
<211> 666
<212> PRT
<213> Homo sapiens

<400> 39
Met Arg Lys Val Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser 
1               5                   10                  15      


Pro Ile Gln Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val 
            20                  25                  30          


Thr Leu Asp Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys 
        35                  40                  45              


Leu Arg Pro Val Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg 
    50                  55                  60                  


Thr His Tyr Tyr Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln 
65                  70                  75                  80  


Leu Asn Glu Leu Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg 
                85                  90                  95      


Thr Ala Gly Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn 
            100                 105                 110         


Trp Thr Gly Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe 
        115                 120                 125             


Ser Ala Ser Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu 
    130                 135                 140                 


Cys Arg Leu Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser 
145                 150                 155                 160 


Gln Glu Pro Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp 
                165                 170                 175     


Gly Ala Gly Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp 
            180                 185                 190         


Leu Ser Asp Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp 
        195                 200                 205             


Asn Thr Arg Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg 
    210                 215                 220                 


Val Pro Ser His Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp 
225                 230                 235                 240 


Ala Ile Trp Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp 
                245                 250                 255     


Lys Ser Pro Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp 
            260                 265                 270         


Leu Leu Phe Lys Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg 
        275                 280                 285             


Ile Asp Ser Gly Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln 
    290                 295                 300                 


Asn Leu Arg Lys Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val 
305                 310                 315                 320 


Val Trp Cys Ala Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp 
                325                 330                 335     


Ser Gly Leu Ser Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr 
            340                 345                 350         


Glu Asp Cys Ile Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser 
        355                 360                 365             


Leu Asp Gly Gly Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro 
    370                 375                 380                 


Val Leu Ala Glu Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro 
385                 390                 395                 400 


Asn Cys Val Asp Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val 
                405                 410                 415     


Arg Arg Ser Asp Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys 
            420                 425                 430         


Ser Cys His Thr Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met 
        435                 440                 445             


Gly Leu Leu Phe Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe 
    450                 455                 460                 


Ser Gln Ser Cys Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala 
465                 470                 475                 480 


Leu Cys Ile Gly Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser 
                485                 490                 495     


Asn Glu Arg Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu 
            500                 505                 510         


Asn Ala Gly Asp Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn 
        515                 520                 525             


Thr Asp Gly Asn Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala 
    530                 535                 540                 


Asp Phe Ala Leu Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu 
545                 550                 555                 560 


Ala Arg Ser Cys His Leu Ala Met Ala Pro Asn His Ala Val Val Ser 
                565                 570                 575     


Arg Met Asp Lys Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln 
            580                 585                 590         


Ala Lys Phe Gly Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu 
        595                 600                 605             


Phe Gln Ser Glu Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys 
    610                 615                 620                 


Leu Ala Arg Leu His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro 
625                 630                 635                 640 


Gln Tyr Val Ala Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro 
                645                 650                 655     


Leu Leu Glu Ala Cys Glu Phe Leu Arg Lys 
            660                 665     


<210> 40
<211> 4655
<212> PRT
<213> Homo sapiens

<400> 40
Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210> 41
<211> 4544
<212> PRT
<213> Homo sapiens

<400> 41
Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Pro  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210> 42
<211> 375
<212> PRT
<213> Homo sapiens

<400> 42
Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210> 43
<211> 198
<212> PRT
<213> Homo sapiens

<400> 43
Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          


Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              


Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  


Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  


Phe Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu 
                85                  90                  95      


Gly Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser 
            100                 105                 110         


Glu Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly 
        115                 120                 125             


Leu Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn 
    130                 135                 140                 


Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln 
145                 150                 155                 160 


Ala Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp 
                165                 170                 175     


Lys Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu 
            180                 185                 190         


Tyr Phe Ser Lys His Asn 
        195             


<210> 44
<211> 124
<212> PRT
<213> Homo sapiens

<400> 44
Ser Phe Ser Ser Met Glu Ala Ser Ser Ala Leu Cys Trp Gly Val Met 
1               5                   10                  15      


Ala Ser Ser Leu Leu Ala Ser Leu Ala Ile Glu Arg Val Met Arg Pro 
            20                  25                  30          


Leu Arg Leu Pro Trp Leu Leu Ala Val Leu Arg Pro Leu Glu Ala Thr 
        35                  40                  45              


Ala Ser Phe Ser Ser Leu Ser Ser Pro Glu Val Ser Ser Val Phe Ser 
    50                  55                  60                  


Leu Arg Arg Ser Ser Leu Ser Phe Ser Thr Ser Gly Phe Ser Ser Ser 
65                  70                  75                  80  


Phe Ser Ala Ser Phe Ser Phe Ser Phe Ser Ser Phe Ser Ser Trp Leu 
                85                  90                  95      


Leu Arg Gly Met Gly Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys 
            100                 105                 110         


Cys Cys Cys Cys Cys Trp Leu Leu Pro Arg Arg Arg 
        115                 120                 

