                         SEQUENCE LISTING

<110>  Attagene Inc.
       Bugno, Marcin
       Rouse, Jeremy
       Makarov, Sergei
       Romanov, Sergei
       Medvedeva, Lioubov
 
<120>  Modulators Of TNFa-Dependent Signaling Pathways And Uses Thereof

<130>  31486-501001WO

<150>  US 61/055,245
<151>  2008-05-22

<150>  US 61/097,369
<151>  2008-09-16

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  1526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPINT1 deletion variant

<400>  1
gtcgacccac gcgtccggtc acaagcaccc tcggaacccg gaggctcgca ctgtgaaggt       60

gacccccgcc tcggggagga gggcgacggc ccctgggagc acgatggcgg gccgccgcct      120

ggcgcgggcc agcatctctg cggtcggcgt atggctcctt tgcgcgcttg gcctccaggc      180

caccgaggcc gagctgccgt ccgcacccgc tgagcttccc gggggagccg cctgcttgag      240

ccgctttacc agcggggtgc cgtcctttgt gctggacacc gaagcctcag tcagcaacgg      300

ggccaccttc ctgggttccc cgacggcgcg ccgcggctgg gactgcgtgc gctcctgctg      360

caccactcag aactgcaacc tggcgctggt ggagctgcag ccagacggcg gcgaggacgc      420

catctctgcc tgcttcctca tgaactgcct gtacgagcag aacttcgtgt gcaagttcgc      480

tccgaaggag ggcttcatca actatcttac ccaggagctt taccgctcct accgcgagct      540

gcggactcga ggctttggag ggtcccggat ccctcgaatc tggatgggca tagacttgaa      600

ggtccagctg cagaagcccc tggtactgaa cgaggcagac aacacagact ggcacctact      660

gcaaggtgac agtgatgtca gagtagagag aaaacgtccg gaagaagtgg agctgtgggg      720

acttaaggag gggacctacc tgttccaact gacaagaact gactcagacc aaccagagga      780

aacagccaac ctgactatca ctgtgctaac tgccaagcag acagaagatt attgcctcgc      840

atcctacaag gtgggccgct gccggggctc cttcccacgc tggtactacg accccaagga      900

acagatctgc aaaagtttta cttttggagg ttgcctgggc aacaagaaca actaccttcg      960

tgaggaagag tgcatgctag cctgcaagga tgtgcaagga atctcaccga aaaggcacca     1020

tccagtgtgc tccggcagct gccatgccac ccagttccgc tgtagcaatg gctgctgtat     1080

cgatggcttc ctggagtgtg atgacacgcc agactgccct gatggctccg acgaggccac     1140

ctgtgaaaaa tacaccagcg gctttgatga gcttcagaat atccatttcc tcagtgacaa     1200

agggtactgt gcagagctgc cagacactgg gttttgcaag gagaacatca cccgctggta     1260

ttacaaccca ttcagtgaac gctgtgcccg attcacctat ggtggttgct atgggaacaa     1320

gaacaacttt gaggaggaac agcagtgcct tgagtcctgc cgtggcatct ccaagaagga     1380

tgtgtttggt cttcggaggg aaggctccat tcccactgta ggctccgctg aggtagctat     1440

tgctgtattt ctggtcatct gcatcatagt ggtcttaacc atcctgggct actgtttctt     1500

caagaacccc ttaattaact agttaa                                          1526


<210>  2
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 deletion variant

<400>  2

Met Ala Gly Arg Arg Leu Ala Arg Ala Ser Ile Ser Ala Val Gly Val 
1               5                   10                  15      


Trp Leu Leu Cys Ala Leu Gly Leu Gln Ala Thr Glu Ala Glu Leu Pro 
            20                  25                  30          


Ser Ala Pro Ala Glu Leu Pro Gly Gly Ala Ala Cys Leu Ser Arg Phe 
        35                  40                  45              


Thr Ser Gly Val Pro Ser Phe Val Leu Asp Thr Glu Ala Ser Val Ser 
    50                  55                  60                  


Asn Gly Ala Thr Phe Leu Gly Ser Pro Thr Ala Arg Arg Gly Trp Asp 
65                  70                  75                  80  


Cys Val Arg Ser Cys Cys Thr Thr Gln Asn Cys Asn Leu Ala Leu Val 
                85                  90                  95      


Glu Leu Gln Pro Asp Gly Gly Glu Asp Ala Ile Ser Ala Cys Phe Leu 
            100                 105                 110         


Met Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe Ala Pro Lys 
        115                 120                 125             


Glu Gly Phe Ile Asn Tyr Leu Thr Gln Glu Leu Tyr Arg Ser Tyr Arg 
    130                 135                 140                 


Glu Leu Arg Thr Arg Gly Phe Gly Gly Ser Arg Ile Pro Arg Ile Trp 
145                 150                 155                 160 


Met Gly Ile Asp Leu Lys Val Gln Leu Gln Lys Pro Leu Val Leu Asn 
                165                 170                 175     


Glu Ala Asp Asn Thr Asp Trp His Leu Leu Gln Gly Asp Ser Asp Val 
            180                 185                 190         


Arg Val Glu Arg Lys Arg Pro Glu Glu Val Glu Leu Trp Gly Leu Lys 
        195                 200                 205             


Glu Gly Thr Tyr Leu Phe Gln Leu Thr Arg Thr Asp Ser Asp Gln Pro 
    210                 215                 220                 


Glu Glu Thr Ala Asn Leu Thr Ile Thr Val Leu Thr Ala Lys Gln Thr 
225                 230                 235                 240 


Glu Asp Tyr Cys Leu Ala Ser Tyr Lys Val Gly Arg Cys Arg Gly Ser 
                245                 250                 255     


Phe Pro Arg Trp Tyr Tyr Asp Pro Lys Glu Gln Ile Cys Lys Ser Phe 
            260                 265                 270         


Thr Phe Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu 
        275                 280                 285             


Glu Cys Met Leu Ala Cys Lys Asp Val Gln Gly Ile Ser Pro Lys Arg 
    290                 295                 300                 


His His Pro Val Cys Ser Gly Ser Cys His Ala Thr Gln Phe Arg Cys 
305                 310                 315                 320 


Ser Asn Gly Cys Cys Ile Asp Gly Phe Leu Glu Cys Asp Asp Thr Pro 
                325                 330                 335     


Asp Cys Pro Asp Gly Ser Asp Glu Ala Thr Cys Glu Lys Tyr Thr Ser 
            340                 345                 350         


Gly Phe Asp Glu Leu Gln Asn Ile His Phe Leu Ser Asp Lys Gly Tyr 
        355                 360                 365             


Cys Ala Glu Leu Pro Asp Thr Gly Phe Cys Lys Glu Asn Ile Thr Arg 
    370                 375                 380                 


Trp Tyr Tyr Asn Pro Phe Ser Glu Arg Cys Ala Arg Phe Thr Tyr Gly 
385                 390                 395                 400 


Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu Glu Glu Gln Gln Cys Leu 
                405                 410                 415     


Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp Val Phe Gly Leu Arg Arg 
            420                 425                 430         


Glu Gly Ser Ile Pro Thr Val Gly Ser Ala Glu Val Ala Ile Ala Val 
        435                 440                 445             


Phe Leu Val Ile Cys Ile Ile Val Val Leu Thr Ile Leu Gly Tyr Cys 
    450                 455                 460                 


Phe Phe Lys Asn Pro Leu Ile Asn 
465                 470         


<210>  3
<211>  1644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TMPRSS4

<400>  3
gaattcggca cgagggagag gcagcagctt gctcagcgga caaggatgct gggcgtgagg       60

gaccaaggcc tgccctgcac tcgggcctcc tccagccagt gctgaccagg gacttctgac      120

ctgctggcca gccaggacct gtgtggggag gccctcctgc tgccttgggg tgacaatctc      180

agctccaggc tacagggaga ccgggaggat cacagagcca gcatgttaca ggatcctgac      240

agtgatcaac ctctgaacag cctcgatgtc aaacccctgc gcaaaccccg tatccccatg      300

gagaccttca gaaaggtggg gatccccatc atcatagcac tactgagcct ggcgagtatc      360

atcattgtgg ttgtcctcat caaggtgatt ctggataaat actacttcct ctgcgggcag      420

cctctccact tcatcccgag gaagcagctg tgtgacggag agctggactg tcccttgggg      480

gaggacgagg agcactgtgt caagagcttc cccgaagggc ctgcagtggc agtccgcctc      540

tccaaggacc gatccacact gcaggtgctg gactcggcca cagggaactg gttctctgcc      600

tgtttcgaca acttcacaga agctctcgct gagacagcct gtaggcagat gggctacagc      660

agcaaaccca ctttcagagc tgtggagatt ggcccagacc aggatctgga tgttgttgaa      720

atcacagaaa acagccagga gcttcgcatg cggaactcaa gtgggccctg tctctcaggc      780

tccctggtct ccctgcactg tcttgcctgt gggaagagcc tgaagacccc ccgtgtggtg      840

ggtggggagg aggcctctgt ggattcttgg ccttggcagg tcagcatcca gtacgacaaa      900

cagcacgtct gtggagggag catcctggac ccccactggg tcctcacggc agcccactgc      960

ttcaggaaac ataccgatgt gttcaactgg aaggtgcggg caggctcaga caaactgggc     1020

agcttcccat ccctggctgt ggccaagatc atcatcattg aattcaaccc catgtacccc     1080

aaagacaatg acatcgccct catgaagctg cagttcccac tcactttctc aggcacagtc     1140

aggcccatct gtctgccctt ctttgatgag gagctcactc cagccacccc actctggatc     1200

attggatggg gctttacgaa gcagaatgga gggaagatgt ctgacatact gctgcaggcg     1260

tcagtccagg tcattgacag cacacggtgc aatgcagacg atgcgtacca gggggaagtc     1320

accgagaaga tgatgtgtgc aggcatcccg gaagggggtg tggacacctg ccagggtgac     1380

agtggtgggc ccctgatgta ccaatctgac cagtggcatg tggtgggcat cgttagctgg     1440

ggctatggct gcgggggccc gagcacccca ggagtataca ccaaggtctc agcctatctc     1500

aactggatct acaatgtctg gaaggctgag ctgtaatgct gctgcccctt tgcagtgctg     1560

ggagccgctt ccttcctgcc ctgcccacct ggggatcccc caaagtcaga cacagagcaa     1620

gagtcccctt aattaactag ttaa                                            1644


<210>  4
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMPRSS4

<400>  4

Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val 
1               5                   10                  15      


Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val 
            20                  25                  30          


Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile 
        35                  40                  45              


Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys 
    50                  55                  60                  


Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu 
65                  70                  75                  80  


Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe 
                85                  90                  95      


Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr 
            100                 105                 110         


Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe 
        115                 120                 125             


Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly 
    130                 135                 140                 


Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln 
145                 150                 155                 160 


Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met 
                165                 170                 175     


Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His 
            180                 185                 190         


Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly 
        195                 200                 205             


Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr 
    210                 215                 220                 


Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val 
225                 230                 235                 240 


Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp 
                245                 250                 255     


Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala 
            260                 265                 270         


Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp 
        275                 280                 285             


Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly 
    290                 295                 300                 


Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro 
305                 310                 315                 320 


Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly 
                325                 330                 335     


Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp 
            340                 345                 350         


Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu 
        355                 360                 365             


Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln 
    370                 375                 380                 


Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val 
385                 390                 395                 400 


Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro 
                405                 410                 415     


Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val 
            420                 425                 430         


Trp Lys Ala Glu Leu 
        435         


<210>  5
<211>  507
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Gly Arg Arg Leu Ala Arg Ala Ser Ile Ser Ala Val Gly Val 
1               5                   10                  15      


Trp Leu Leu Cys Ala Leu Gly Leu Gln Ala Thr Glu Ala Glu Leu Pro 
            20                  25                  30          


Ser Ala Pro Ala Glu Leu Pro Gly Gly Ala Ala Cys Leu Ser Arg Phe 
        35                  40                  45              


Thr Ser Gly Val Pro Ser Phe Val Leu Asp Thr Glu Ala Ser Val Ser 
    50                  55                  60                  


Asn Gly Ala Thr Phe Leu Gly Ser Pro Thr Ala Arg Arg Gly Trp Asp 
65                  70                  75                  80  


Cys Val Arg Ser Cys Cys Thr Thr Gln Asn Cys Asn Leu Ala Leu Val 
                85                  90                  95      


Glu Leu Gln Pro Asp Gly Gly Glu Asp Ala Ile Ser Ala Cys Phe Leu 
            100                 105                 110         


Met Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe Ala Pro Lys 
        115                 120                 125             


Glu Gly Phe Ile Asn Tyr Leu Thr Gln Glu Leu Tyr Arg Ser Tyr Arg 
    130                 135                 140                 


Glu Leu Arg Thr Arg Gly Phe Gly Gly Ser Arg Ile Pro Arg Ile Trp 
145                 150                 155                 160 


Met Gly Ile Asp Leu Lys Val Gln Leu Gln Lys Pro Leu Val Leu Asn 
                165                 170                 175     


Glu Ala Asp Asn Thr Asp Trp His Leu Leu Gln Gly Asp Ser Asp Val 
            180                 185                 190         


Arg Val Glu Arg Lys Arg Pro Glu Glu Val Glu Leu Trp Gly Leu Lys 
        195                 200                 205             


Glu Gly Thr Tyr Leu Phe Gln Leu Thr Arg Thr Asp Ser Asp Gln Pro 
    210                 215                 220                 


Glu Glu Thr Ala Asn Leu Thr Ile Thr Val Leu Thr Ala Lys Gln Thr 
225                 230                 235                 240 


Glu Asp Tyr Cys Leu Ala Ser Tyr Lys Val Gly Arg Cys Arg Gly Ser 
                245                 250                 255     


Phe Pro Arg Trp Tyr Tyr Asp Pro Lys Glu Gln Ile Cys Lys Ser Phe 
            260                 265                 270         


Thr Phe Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu 
        275                 280                 285             


Glu Cys Met Leu Ala Cys Lys Asp Val Gln Gly Ile Ser Pro Lys Arg 
    290                 295                 300                 


His His Pro Val Cys Ser Gly Ser Cys His Ala Thr Gln Phe Arg Cys 
305                 310                 315                 320 


Ser Asn Gly Cys Cys Ile Asp Gly Phe Leu Glu Cys Asp Asp Thr Pro 
                325                 330                 335     


Asp Cys Pro Asp Gly Ser Asp Glu Ala Thr Cys Glu Lys Tyr Thr Ser 
            340                 345                 350         


Gly Phe Asp Glu Leu Gln Asn Ile His Phe Leu Ser Asp Lys Gly Tyr 
        355                 360                 365             


Cys Ala Glu Leu Pro Asp Thr Gly Phe Cys Lys Glu Asn Ile Pro Arg 
    370                 375                 380                 


Trp Tyr Tyr Asn Pro Phe Ser Glu Arg Cys Ala Arg Phe Thr Tyr Gly 
385                 390                 395                 400 


Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu Glu Glu Gln Gln Cys Leu 
                405                 410                 415     


Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp Val Phe Gly Leu Arg Arg 
            420                 425                 430         


Glu Gly Ser Ile Pro Thr Val Gly Ser Ala Glu Val Ala Ile Ala Val 
        435                 440                 445             


Phe Leu Val Ile Cys Ile Ile Val Val Leu Thr Ile Leu Gly Tyr Cys 
    450                 455                 460                 


Phe Phe Lys Asn Gln Arg Lys Glu Phe His Ser Pro Leu His His Pro 
465                 470                 475                 480 


Pro Pro Thr Pro Ala Ser Ser Thr Val Ser Thr Thr Glu Asp Thr Glu 
                485                 490                 495     


His Leu Val Tyr Asn His Thr Thr Gln Pro Leu 
            500                 505         


<210>  6
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Arg Ala Arg Leu Ala Pro Ala Gly Ile Pro Ala Val Ala Leu 
1               5                   10                  15      


Trp Leu Leu Cys Thr Leu Gly Leu Gln Gly Thr Gln Ala Gly Pro Pro 
            20                  25                  30          


Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala Asp Cys Leu Asn Ser Phe 
        35                  40                  45              


Thr Ala Gly Val Pro Gly Phe Val Leu Asp Thr Asn Ala Ser Val Ser 
    50                  55                  60                  


Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr Val Arg Arg Gly Trp Asp 
65                  70                  75                  80  


Cys Val Arg Ala Cys Cys Thr Thr Gln Asn Cys Asn Leu Ala Leu Val 
                85                  90                  95      


Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala Ile Ala Ala Cys Phe Leu 
            100                 105                 110         


Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe Ala Pro Arg 
        115                 120                 125             


Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu Val Tyr Arg Ser Tyr Arg 
    130                 135                 140                 


Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser Gly Ile Pro Lys Ala Trp 
145                 150                 155                 160 


Ala Gly Ile Asp Leu Lys Val Gln Pro Gln Glu Pro Leu Val Leu Lys 
                165                 170                 175     


Asp Val Glu Asn Thr Asp Trp Arg Leu Leu Arg Gly Asp Thr Asp Val 
            180                 185                 190         


Arg Val Glu Arg Lys Asp Pro Asn Gln Val Glu Leu Trp Gly Leu Lys 
        195                 200                 205             


Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val Thr Ser Ser Asp His Pro 
    210                 215                 220                 


Glu Asp Thr Ala Asn Val Thr Val Thr Val Leu Ser Thr Lys Gln Thr 
225                 230                 235                 240 


Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val Gly Arg Cys Arg Gly Ser 
                245                 250                 255     


Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln Ile Cys Lys Ser Phe 
            260                 265                 270         


Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu 
        275                 280                 285             


Glu Cys Ile Leu Ala Cys Arg Gly Val Gln Gly Pro Ser Met Glu Arg 
    290                 295                 300                 


Arg His Pro Val Cys Ser Gly Thr Cys Gln Pro Thr Gln Phe Arg Cys 
305                 310                 315                 320 


Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu Glu Cys Asp Asp Thr Pro 
                325                 330                 335     


Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala Cys Glu Lys Tyr Thr Ser 
            340                 345                 350         


Gly Phe Asp Glu Leu Gln Arg Ile His Phe Pro Ser Asp Lys Gly His 
        355                 360                 365             


Cys Val Asp Leu Pro Asp Thr Gly Leu Cys Lys Glu Ser Ile Pro Arg 
    370                 375                 380                 


Trp Tyr Tyr Asn Pro Phe Ser Glu His Cys Ala Arg Phe Thr Tyr Gly 
385                 390                 395                 400 


Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu Glu Glu Gln Gln Cys Leu 
                405                 410                 415     


Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp Val Phe Gly Leu Arg Arg 
            420                 425                 430         


Glu Ile Pro Ile Pro Ser Thr Gly Ser Val Glu Met Ala Val Ala Val 
        435                 440                 445             


Phe Leu Val Ile Cys Ile Val Val Val Val Ala Ile Leu Gly Tyr Cys 
    450                 455                 460                 


Phe Phe Lys Asn Gln Arg Lys Asp Phe His Gly His His His His Pro 
465                 470                 475                 480 


Pro Pro Thr Pro Ala Ser Ser Thr Val Ser Thr Thr Glu Asp Thr Glu 
                485                 490                 495     


His Leu Val Tyr Asn His Thr Thr Arg Pro Leu 
            500                 505         


<210>  7
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mus musculus splint Deletion Variant

<400>  7

Met Ala Gly Arg Arg Leu Ala Arg Ala Ser Ile Ser Ala Val Gly Val 
1               5                   10                  15      


Trp Leu Leu Cys Ala Leu Gly Leu Gln Ala Thr Glu Ala Glu Leu Pro 
            20                  25                  30          


Ser Ala Pro Ala Glu Leu Pro Gly Gly Ala Ala Cys Leu Ser Arg Phe 
        35                  40                  45              


Thr Ser Gly Val Pro Ser Phe Val Leu Asp Thr Glu Ala Ser Val Ser 
    50                  55                  60                  


Asn Gly Ala Thr Phe Leu Gly Ser Pro Thr Ala Arg Arg Gly Trp Asp 
65                  70                  75                  80  


Cys Val Arg Ser Cys Cys Thr Thr Gln Asn Cys Asn Leu Ala Leu Val 
                85                  90                  95      


Glu Leu Gln Pro Asp Gly Gly Glu Asp Ala Ile Ser Ala Cys Phe Leu 
            100                 105                 110         


Met Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe Ala Pro Lys 
        115                 120                 125             


Glu Gly Phe Ile Asn Tyr Leu Thr Gln Glu Leu Tyr Arg Ser Tyr Arg 
    130                 135                 140                 


Glu Leu Arg Thr Arg Gly Phe Gly Gly Ser Arg Ile Pro Arg Ile Trp 
145                 150                 155                 160 


Met Gly Ile Asp Leu Lys Val Gln Leu Gln Lys Pro Leu Val Leu Asn 
                165                 170                 175     


Glu Ala Asp Asn Thr Asp Trp His Leu Leu Gln Gly Asp Ser Asp Val 
            180                 185                 190         


Arg Val Glu Arg Lys Arg Pro Glu Glu Val Glu Leu Trp Gly Leu Lys 
        195                 200                 205             


Glu Gly Thr Tyr Leu Phe Gln Leu Thr Arg Thr Asp Ser Asp Gln Pro 
    210                 215                 220                 


Glu Glu Thr Ala Asn Leu Thr Ile Thr Val Leu Thr Ala Lys Gln Thr 
225                 230                 235                 240 


Glu Asp Tyr Cys Leu Ala Ser Tyr Lys Val Gly Arg Cys Arg Gly Ser 
                245                 250                 255     


Phe Pro Arg Trp Tyr Tyr Asp Pro Lys Glu Gln Ile Cys Lys Ser Phe 
            260                 265                 270         


Thr Phe Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu 
        275                 280                 285             


Glu Cys Met Leu Ala Cys Lys Asp Val Gln Gly Ile Ser Pro Lys Arg 
    290                 295                 300                 


His His Pro Val Cys Ser Gly Ser Cys His Ala Thr Gln Phe Arg Cys 
305                 310                 315                 320 


Ser Asn Gly Cys Cys Ile Asp Gly Phe Leu Glu Cys Asp Asp Thr Pro 
                325                 330                 335     


Asp Cys Pro Asp Gly Ser Asp Glu Ala Thr Cys Glu Lys Tyr Thr Ser 
            340                 345                 350         


Gly Phe Asp Glu Leu Gln Asn Ile His Phe Leu Ser Asp Lys Gly Tyr 
        355                 360                 365             


Cys Ala Glu Leu Pro Asp Thr Gly Phe Cys Lys Glu Asn Ile Pro Arg 
    370                 375                 380                 


Trp Tyr Tyr Asn Pro Phe Ser Glu Arg Cys Ala Arg Phe Thr Tyr Gly 
385                 390                 395                 400 


Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu Glu Glu Gln Gln Cys Leu 
                405                 410                 415     


Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp Val Phe Gly Leu Arg Arg 
            420                 425                 430         


Glu Gly Ser Ile Pro Thr Val Gly Ser Ala Glu Val Ala Ile Ala Val 
        435                 440                 445             


Phe Leu Val Ile Cys Ile Ile Val Val Leu Thr Ile Leu Gly Tyr Cys 
    450                 455                 460                 


Phe Phe Lys Asn 
465             


<210>  8
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens spintl Deletion Variant

<400>  8

Met Ala Arg Ala Arg Leu Ala Pro Ala Gly Ile Pro Ala Val Ala Leu 
1               5                   10                  15      


Trp Leu Leu Cys Thr Leu Gly Leu Gln Gly Thr Gln Ala Gly Pro Pro 
            20                  25                  30          


Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala Asp Cys Leu Asn Ser Phe 
        35                  40                  45              


Thr Ala Gly Val Pro Gly Phe Val Leu Asp Thr Asn Ala Ser Val Ser 
    50                  55                  60                  


Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr Val Arg Arg Gly Trp Asp 
65                  70                  75                  80  


Cys Val Arg Ala Cys Cys Thr Thr Gln Asn Cys Asn Leu Ala Leu Val 
                85                  90                  95      


Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala Ile Ala Ala Cys Phe Leu 
            100                 105                 110         


Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe Ala Pro Arg 
        115                 120                 125             


Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu Val Tyr Arg Ser Tyr Arg 
    130                 135                 140                 


Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser Gly Ile Pro Lys Ala Trp 
145                 150                 155                 160 


Ala Gly Ile Asp Leu Lys Val Gln Pro Gln Glu Pro Leu Val Leu Lys 
                165                 170                 175     


Asp Val Glu Asn Thr Asp Trp Arg Leu Leu Arg Gly Asp Thr Asp Val 
            180                 185                 190         


Arg Val Glu Arg Lys Asp Pro Asn Gln Val Glu Leu Trp Gly Leu Lys 
        195                 200                 205             


Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val Thr Ser Ser Asp His Pro 
    210                 215                 220                 


Glu Asp Thr Ala Asn Val Thr Val Thr Val Leu Ser Thr Lys Gln Thr 
225                 230                 235                 240 


Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val Gly Arg Cys Arg Gly Ser 
                245                 250                 255     


Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln Ile Cys Lys Ser Phe 
            260                 265                 270         


Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu 
        275                 280                 285             


Glu Cys Ile Leu Ala Cys Arg Gly Val Gln Gly Pro Ser Met Glu Arg 
    290                 295                 300                 


Arg His Pro Val Cys Ser Gly Thr Cys Gln Pro Thr Gln Phe Arg Cys 
305                 310                 315                 320 


Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu Glu Cys Asp Asp Thr Pro 
                325                 330                 335     


Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala Cys Glu Lys Tyr Thr Ser 
            340                 345                 350         


Gly Phe Asp Glu Leu Gln Arg Ile His Phe Pro Ser Asp Lys Gly His 
        355                 360                 365             


Cys Val Asp Leu Pro Asp Thr Gly Leu Cys Lys Glu Ser Ile Pro Arg 
    370                 375                 380                 


Trp Tyr Tyr Asn Pro Phe Ser Glu His Cys Ala Arg Phe Thr Tyr Gly 
385                 390                 395                 400 


Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu Glu Glu Gln Gln Cys Leu 
                405                 410                 415     


Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp Val Phe Gly Leu Arg Arg 
            420                 425                 430         


Glu Ile Pro Ile Pro Ser Thr Gly Ser Val Glu Met Ala Val Ala Val 
        435                 440                 445             


Phe Leu Val Ile Cys Ile Val Val Val Val Ala Ile Leu Gly Tyr Cys 
    450                 455                 460                 


Phe Phe Lys Asn 
465             


<210>  9
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mus musculus spint1 deletion variant excluding predicted signal 
       peptide sequence

<400>  9

Thr Glu Ala Glu Leu Pro Ser Ala Pro Ala Glu Leu Pro Gly Gly Ala 
1               5                   10                  15      


Ala Cys Leu Ser Arg Phe Thr Ser Gly Val Pro Ser Phe Val Leu Asp 
            20                  25                  30          


Thr Glu Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Gly Ser Pro Thr 
        35                  40                  45              


Ala Arg Arg Gly Trp Asp Cys Val Arg Ser Cys Cys Thr Thr Gln Asn 
    50                  55                  60                  


Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Gly Gly Glu Asp Ala 
65                  70                  75                  80  


Ile Ser Ala Cys Phe Leu Met Asn Cys Leu Tyr Glu Gln Asn Phe Val 
                85                  90                  95      


Cys Lys Phe Ala Pro Lys Glu Gly Phe Ile Asn Tyr Leu Thr Gln Glu 
            100                 105                 110         


Leu Tyr Arg Ser Tyr Arg Glu Leu Arg Thr Arg Gly Phe Gly Gly Ser 
        115                 120                 125             


Arg Ile Pro Arg Ile Trp Met Gly Ile Asp Leu Lys Val Gln Leu Gln 
    130                 135                 140                 


Lys Pro Leu Val Leu Asn Glu Ala Asp Asn Thr Asp Trp His Leu Leu 
145                 150                 155                 160 


Gln Gly Asp Ser Asp Val Arg Val Glu Arg Lys Arg Pro Glu Glu Val 
                165                 170                 175     


Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Arg 
            180                 185                 190         


Thr Asp Ser Asp Gln Pro Glu Glu Thr Ala Asn Leu Thr Ile Thr Val 
        195                 200                 205             


Leu Thr Ala Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Tyr Lys Val 
    210                 215                 220                 


Gly Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Lys Glu 
225                 230                 235                 240 


Gln Ile Cys Lys Ser Phe Thr Phe Gly Gly Cys Leu Gly Asn Lys Asn 
                245                 250                 255     


Asn Tyr Leu Arg Glu Glu Glu Cys Met Leu Ala Cys Lys Asp Val Gln 
            260                 265                 270         


Gly Ile Ser Pro Lys Arg His His Pro Val Cys Ser Gly Ser Cys His 
        275                 280                 285             


Ala Thr Gln Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Gly Phe Leu 
    290                 295                 300                 


Glu Cys Asp Asp Thr Pro Asp Cys Pro Asp Gly Ser Asp Glu Ala Thr 
305                 310                 315                 320 


Cys Glu Lys Tyr Thr Ser Gly Phe Asp Glu Leu Gln Asn Ile His Phe 
                325                 330                 335     


Leu Ser Asp Lys Gly Tyr Cys Ala Glu Leu Pro Asp Thr Gly Phe Cys 
            340                 345                 350         


Lys Glu Asn Ile Pro Arg Trp Tyr Tyr Asn Pro Phe Ser Glu Arg Cys 
        355                 360                 365             


Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu 
    370                 375                 380                 


Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp 
385                 390                 395                 400 


Val Phe Gly Leu Arg Arg Glu Gly Ser Ile Pro Thr Val Gly Ser Ala 
                405                 410                 415     


Glu Val Ala Ile Ala Val Phe Leu Val Ile Cys Ile Ile Val Val Leu 
            420                 425                 430         


Thr Ile Leu Gly Tyr Cys Phe Phe Lys Asn 
        435                 440         


<210>  10
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens spint1 deletion variant excluding predicted signal 
       peptide sequence

<400>  10

Thr Gln Ala Gly Pro Pro Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala 
1               5                   10                  15      


Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu Asp 
            20                  25                  30          


Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr 
        35                  40                  45              


Val Arg Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln Asn 
    50                  55                  60                  


Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala 
65                  70                  75                  80  


Ile Ala Ala Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val 
                85                  90                  95      


Cys Lys Phe Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu 
            100                 105                 110         


Val Tyr Arg Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser 
        115                 120                 125             


Gly Ile Pro Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln 
    130                 135                 140                 


Glu Pro Leu Val Leu Lys Asp Val Glu Asn Thr Asp Trp Arg Leu Leu 
145                 150                 155                 160 


Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys Asp Pro Asn Gln Val 
                165                 170                 175     


Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val 
            180                 185                 190         


Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr Val 
        195                 200                 205             


Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val 
    210                 215                 220                 


Gly Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu 
225                 230                 235                 240 


Gln Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn 
                245                 250                 255     


Asn Tyr Leu Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln 
            260                 265                 270         


Gly Pro Ser Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln 
        275                 280                 285             


Pro Thr Gln Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu 
    290                 295                 300                 


Glu Cys Asp Asp Thr Pro Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala 
305                 310                 315                 320 


Cys Glu Lys Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His Phe 
                325                 330                 335     


Pro Ser Asp Lys Gly His Cys Val Asp Leu Pro Asp Thr Gly Leu Cys 
            340                 345                 350         


Lys Glu Ser Ile Pro Arg Trp Tyr Tyr Asn Pro Phe Ser Glu His Cys 
        355                 360                 365             


Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu 
    370                 375                 380                 


Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp 
385                 390                 395                 400 


Val Phe Gly Leu Arg Arg Glu Ile Pro Ile Pro Ser Thr Gly Ser Val 
                405                 410                 415     


Glu Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val 
            420                 425                 430         


Ala Ile Leu Gly Tyr Cys Phe Phe Lys Asn 
        435                 440         


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived sequence from SPINT1

<400>  11

Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala 
1               5                   10                  15      


Ile Leu 
        


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Met Ala Val Ala Val Xaa Leu Val Ile Cys Ile Val Val Val Val Ala 
1               5                   10                  15      


Ile Leu 
        


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Ala Val Ala Val Xaa Leu Val Ile Cys Xaa Val Val Val Val Ala 
1               5                   10                  15      


Xaa Leu 
        


<210>  14
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Met Xaa Val Xaa Val Phe Leu Val Ile Cys Ile Val Val Val Val Xaa 
1               5                   10                  15      


Ile Leu 
        


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Xaa Ala Val Ala Val Xaa Xaa Val Ile Cys Ile Val Val Val Val Ala 
1               5                   10                  15      


Ile Leu 
        


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Xaa Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala 
1               5                   10                  15      


Xaa Leu 
        


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Met Ala Val Ala Val Phe Xaa Val Ile Cys Ile Val Val Xaa Val Ala 
1               5                   10                  15      


Ile Leu 
        


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Met Ala Val Ala Val Phe Xaa Val Ile Cys Ile Val Xaa Val Val Ala 
1               5                   10                  15      


Ile Xaa 
        


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Xaa Xaa Val Xaa Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala 
1               5                   10                  15      


Xaa Xaa 
        


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  20

Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val 
1               5                   10              


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  21

Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala Ile Leu 
1               5                   10                  15      


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  22

Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala Ile 
1               5                   10                  15      


Leu 
    


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  23

Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala 
1               5                   10                  15      


Ile Leu 
        


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  24

Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala 
1               5                   10                  15      


Ile 
    


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  25

Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala 
1               5                   10                  15      


<210>  26
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  26

Arg Glu Ile Pro Ile Pro Ser Thr Gly Ser Val Glu Met Ala Val Ala 
1               5                   10                  15      


Val Phe Leu Val Ile Cys Ile Val Val Val Val Ala Ile Leu 
            20                  25                  30  


<210>  27
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  27

Pro Ile Pro Ser Thr Gly Ser Val Glu Met Ala Val Ala Val Phe Leu 
1               5                   10                  15      


Val Ile Cys Ile Val Val Val Val Ala Ile Leu 
            20                  25          


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  28

Ser Thr Gly Ser Val Glu Met Ala Val Ala Val Phe Leu Val Ile Cys 
1               5                   10                  15      


Ile Val Val Val Val Ala Ile Leu 
            20                  


<210>  29
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  29

Ser Val Glu Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val 
1               5                   10                  15      


Val Val Ala Ile Leu 
            20      


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  30

Val Glu Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val 
1               5                   10                  15      


Val Ala Ile Leu 
            20  


<210>  31
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  31

Ala Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu 
1               5                   10                  15      


Asp Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro 
            20                  25                  30          


Thr Val Arg Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln 
        35                  40                  45              


Asn Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp 
    50                  55                  60                  


Ala Ile Ala Ala Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe 
65                  70                  75                  80  


Val Cys Lys Phe Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg 
                85                  90                  95      


Glu Val Tyr Arg Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly 
            100                 105                 110         


Ser Gly Ile Pro Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro 
        115                 120                 125             


Gln Glu Pro Leu Val Leu Lys Asp Val Glu Asn Thr Asp Trp Arg Leu 
    130                 135                 140                 


Leu Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys Asp Pro Asn Gln 
145                 150                 155                 160 


Val Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr 
                165                 170                 175     


Val Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr 
            180                 185                 190         


Val Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn Lys 
        195                 200                 205             


Val Gly Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr 
    210                 215                 220                 


Glu Gln Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys 
225                 230                 235                 240 


Asn Asn Tyr Leu Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val 
                245                 250                 255     


Gln Gly Pro Ser Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys 
            260                 265                 270         


Gln Pro Thr Gln Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Ser Phe 
        275                 280                 285             


Leu Glu Cys Asp Asp Thr Pro Asn Cys Pro Asp Ala Ser Asp Glu Ala 
    290                 295                 300                 


Ala Cys Glu Lys Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His 
305                 310                 315                 320 


Phe Pro Ser Asp Lys Gly His Cys Val Asp Leu Pro Asp Thr Gly Leu 
                325                 330                 335     


Cys Lys Glu Ser Ile Pro Arg Trp Tyr Tyr Asn Pro Phe Ser Glu His 
            340                 345                 350         


Cys Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn Asn Phe 
        355                 360                 365             


Glu Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser Lys Lys 
    370                 375                 380                 


Asp Val Phe 
385         


<210>  32
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  32

Ala Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu 
1               5                   10                  15      


Asp Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro 
            20                  25                  30          


Thr Val Arg Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln 
        35                  40                  45              


Asn Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp 
    50                  55                  60                  


Ala Ile Ala Ala Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe 
65                  70                  75                  80  


Val Cys Lys Phe Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg 
                85                  90                  95      


Glu Val Tyr Arg Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly 
            100                 105                 110         


Ser Gly Ile Pro Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro 
        115                 120                 125             


Gln Glu Pro Leu Val Leu Lys Asp Val Glu Asn Thr 
    130                 135                 140 


<210>  33
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  33

Asp Trp Arg Leu Leu Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys 
1               5                   10                  15      


Asp Pro Asn Gln Val Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu 
            20                  25                  30          


Phe Gln Leu Thr Val Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn 
        35                  40                  45              


Val Thr Val Thr Val Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu 
    50                  55                  60                  


Ala Ser Asn Lys Val Gly Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr 
65                  70                  75                  80  


Tyr Asp Pro Thr Glu Gln Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys 
                85                  90                  95      


Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu Glu Cys Ile Leu Ala 
            100                 105                 110         


Cys Arg Gly Val Gln Gly Pro Ser Met Glu Arg Arg His Pro Val Cys 
        115                 120                 125             


Ser Gly Thr Cys Gln Pro Thr Gln Phe Arg Cys Ser 
    130                 135                 140 


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  34

Asn Gly Cys Cys Ile Asp Ser Phe Leu Glu Cys Asp Asp Thr Pro Asn 
1               5                   10                  15      


Cys Pro Asp Ala Ser Asp Glu Ala Ala Cys Glu Lys Tyr Thr Ser Gly 
            20                  25                  30          


Phe Asp Glu Leu Gln Arg Ile His Phe Pro Ser Asp Lys Gly His Cys 
        35                  40                  45              


Val Asp Leu Pro Asp Thr Gly Leu Cys Lys Glu Ser Ile Pro Arg Trp 
    50                  55                  60                  


Tyr Tyr Asn Pro Phe Ser Glu His Cys Ala Arg Phe Thr Tyr Gly Gly 
65                  70                  75                  80  


Cys Tyr Gly Asn Lys Asn Asn Phe Glu Glu Glu Gln Gln Cys Leu Glu 
                85                  90                  95      


Ser Cys Arg Gly Ile Ser Lys Lys Asp Val Phe 
            100                 105         


<210>  35
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  35

Ala Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu 
1               5                   10                  15      


Asp Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro 
            20                  25                  30          


Thr Val Arg Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln 
        35                  40                  45              


Asn Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp 
    50                  55                  60                  


Ala Ile Ala Ala Cys Phe 
65                  70  


<210>  36
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  36

Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe Ala Pro 
1               5                   10                  15      


Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu Val Tyr Arg Ser Tyr 
            20                  25                  30          


Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser Gly Ile Pro Lys Ala 
        35                  40                  45              


Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln Glu Pro Leu Val Leu 
    50                  55                  60                  


Lys Asp Val Glu Asn Thr 
65                  70  


<210>  37
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  37

Asp Trp Arg Leu Leu Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys 
1               5                   10                  15      


Asp Pro Asn Gln Val Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu 
            20                  25                  30          


Phe Gln Leu Thr Val Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn 
        35                  40                  45              


Val Thr Val Thr Val Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu 
    50                  55                  60                  


Ala Ser Asn Lys Val Gly 
65                  70  


<210>  38
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  38

Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln 
1               5                   10                  15      


Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn 
            20                  25                  30          


Tyr Leu Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln Gly 
        35                  40                  45              


Pro Ser Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln Pro 
    50                  55                  60                  


Thr Gln Phe Arg Cys Ser 
65                  70  


<210>  39
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  39

Asn Gly Cys Cys Ile Asp Ser Phe Leu Glu Cys Asp Asp Thr Pro Asn 
1               5                   10                  15      


Cys Pro Asp Ala Ser Asp Glu Ala Ala Cys Glu Lys Tyr Thr Ser Gly 
            20                  25                  30          


Phe Asp Glu Leu Gln Arg Ile His Phe Pro Ser Asp Lys Gly His Cys 
        35                  40                  45              


Val Asp Leu Pro Asp Thr Gly Leu Cys Lys Glu Ser Ile Pro Arg Trp 
    50                  55                  60                  


Tyr Tyr Asn Pro Phe Ser 
65                  70  


<210>  40
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  40

Glu His Cys Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn 
1               5                   10                  15      


Asn Phe Glu Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser 
            20                  25                  30          


Lys Lys Asp Val Phe 
        35          


<210>  41
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  41

Ala Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu 
1               5                   10                  15      


Asp Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro 
            20                  25                  30          


Thr Val Arg 
        35  


<210>  42
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  42

Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln Asn Cys Asn 
1               5                   10                  15      


Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala Ile Ala 
            20                  25                  30          


Ala Cys Phe 
        35  


<210>  43
<211>  35
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  43

Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe Ala Pro 
1               5                   10                  15      


Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu Val Tyr Arg Ser Tyr 
            20                  25                  30          


Arg Gln Leu 
        35  


<210>  44
<211>  35
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  44

Arg Thr Gln Gly Phe Gly Gly Ser Gly Ile Pro Lys Ala Trp Ala Gly 
1               5                   10                  15      


Ile Asp Leu Lys Val Gln Pro Gln Glu Pro Leu Val Leu Lys Asp Val 
            20                  25                  30          


Glu Asn Thr 
        35  


<210>  45
<211>  35
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  45

Asp Trp Arg Leu Leu Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys 
1               5                   10                  15      


Asp Pro Asn Gln Val Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu 
            20                  25                  30          


Phe Gln Leu 
        35  


<210>  46
<211>  35
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  46

Thr Val Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn Val Thr Val 
1               5                   10                  15      


Thr Val Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn 
            20                  25                  30          


Lys Val Gly 
        35  


<210>  47
<211>  35
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  47

Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln 
1               5                   10                  15      


Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn 
            20                  25                  30          


Tyr Leu Arg 
        35  


<210>  48
<211>  35
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  48

Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln Gly Pro Ser Met 
1               5                   10                  15      


Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln Pro Thr Gln Phe 
            20                  25                  30          


Arg Cys Ser 
        35  


<210>  49
<211>  35
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  49

Asn Gly Cys Cys Ile Asp Ser Phe Leu Glu Cys Asp Asp Thr Pro Asn 
1               5                   10                  15      


Cys Pro Asp Ala Ser Asp Glu Ala Ala Cys Glu Lys Tyr Thr Ser Gly 
            20                  25                  30          


Phe Asp Glu 
        35  


<210>  50
<211>  35
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  50

Leu Gln Arg Ile His Phe Pro Ser Asp Lys Gly His Cys Val Asp Leu 
1               5                   10                  15      


Pro Asp Thr Gly Leu Cys Lys Glu Ser Ile Pro Arg Trp Tyr Tyr Asn 
            20                  25                  30          


Pro Phe Ser 
        35  


<210>  51
<211>  37
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  51

Glu His Cys Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn 
1               5                   10                  15      


Asn Phe Glu Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser 
            20                  25                  30          


Lys Lys Asp Val Phe 
        35          


<210>  52
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  52

Ala Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu 
1               5                   10                  15      


Asp Thr Asn Ala Ser Val Ser Asn 
            20                  


<210>  53
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  53

Gly Ala Thr Phe Leu Glu Ser Pro Thr Val Arg Arg Gly Trp Asp Cys 
1               5                   10                  15      


Val Arg Ala Cys Cys Thr Thr Gln 
            20                  


<210>  54
<211>  22
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  54

Asn Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp 
1               5                   10                  15      


Ala Ile Ala Ala Cys Phe 
            20          


<210>  55
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  55

Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe Ala Pro 
1               5                   10                  15      


Arg Glu Gly Phe Ile Asn Tyr Leu 
            20                  


<210>  56
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  56

Thr Arg Glu Val Tyr Arg Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe 
1               5                   10                  15      


Gly Gly Ser Gly Ile Pro Lys Ala 
            20                  


<210>  57
<211>  22
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  57

Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln Glu Pro Leu Val Leu 
1               5                   10                  15      


Lys Asp Val Glu Asn Thr 
            20          


<210>  58
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  58

Asp Trp Arg Leu Leu Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys 
1               5                   10                  15      


Asp Pro Asn Gln Val Glu Leu Trp 
            20                  


<210>  59
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  59

Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val Thr Ser Ser 
1               5                   10                  15      


Asp His Pro Glu Asp Thr Ala Asn 
            20                  


<210>  60
<211>  22
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  60

Val Thr Val Thr Val Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu 
1               5                   10                  15      


Ala Ser Asn Lys Val Gly 
            20          


<210>  61
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  Artificial Sequence- SPINT1 polypeptides

<400>  61

Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln 
1               5                   10                  15      


Ile Cys Lys Ser Phe Val Tyr Gly 
            20                  


<210>  62
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  SPINT1 polypeptides

<400>  62

Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu Glu Cys Ile 
1               5                   10                  15      


Leu Ala Cys Arg Gly Val Gln Gly 
            20                  


<210>  63
<211>  22
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  SPINT1 polypeptides

<400>  63

Pro Ser Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln Pro 
1               5                   10                  15      


Thr Gln Phe Arg Cys Ser 
            20          


<210>  64
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  SPINT1 polypeptides

<400>  64

Asn Gly Cys Cys Ile Asp Ser Phe Leu Glu Cys Asp Asp Thr Pro Asn 
1               5                   10                  15      


Cys Pro Asp Ala Ser Asp Glu Ala 
            20                  


<210>  65
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  SPINT1 polypeptides

<400>  65

Ala Cys Glu Lys Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His 
1               5                   10                  15      


Phe Pro Ser Asp Lys Gly His Cys 
            20                  


<210>  66
<211>  22
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  SPINT1 polypeptides

<400>  66

Val Asp Leu Pro Asp Thr Gly Leu Cys Lys Glu Ser Ile Pro Arg Trp 
1               5                   10                  15      


Tyr Tyr Asn Pro Phe Ser 
            20          


<210>  67
<211>  24
<212>  PRT
<213>  Artificial Sequence- SPINT1 polypeptides

<220>
<223>  SPINT1 polypeptides

<400>  67

Glu His Cys Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn 
1               5                   10                  15      


Asn Phe Glu Glu Glu Gln Gln Cys 
            20                  


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINT1 polypeptides

<400>  68

Leu Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp Val Phe 
1               5                   10              


