                         SEQUENCE LISTING

<110>  Schering Corp.

<120>  EGF-A Domain-Mediated Modulation of PCSK9

<130>  JB06822

<150>  61/055,266
<151>  22-05-2008

<160>  46    

<170>  PatentIn version 3.4

<210>  1
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  1

Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu Cys Val Asn 
1               5                   10                  15      


Met Glu Glu Ser Tyr Tyr Cys 
            20              


<210>  2
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 
1               5                   10                  15      


Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 
            20                  25                  30          


Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              


Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  


Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      


Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         


Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             


His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 


Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 


Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     


Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
            180                 185                 190         


Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
        195                 200                 205             


Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 


Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
225                 230                 235                 240 


Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
                245                 250                 255     


Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
            260                 265                 270         


Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 
        275                 280                 285             


Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 
    290                 295                 300                 


Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 
305                 310                 315                 320 


Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     


Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         


Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser 
        355                 360                 365             


Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser 
    370                 375                 380                 


Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys 
385                 390                 395                 400 


Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 
                405                 410                 415     


Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr 
            420                 425                 430         


Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala 
        435                 440                 445             


Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Asp Ser 
    450                 455                 460                 


Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp Leu Lys 
465                 470                 475                 480 


Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu 
                485                 490                 495     


Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu 
            500                 505                 510         


Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser 
        515                 520                 525             


Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu 
    530                 535                 540                 


Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp 
545                 550                 555                 560 


Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly 
                565                 570                 575     


Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys 
            580                 585                 590         


Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys 
        595                 600                 605             


Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys Val Asn 
    610                 615                 620                 


Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val Leu Ala 
625                 630                 635                 640 


Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile Asp Leu 
                645                 650                 655     


Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu 
            660                 665                 670         


Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser 
        675                 680                 685             


Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val His 
    690                 695                 700                 


Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met Lys Lys 
705                 710                 715                 720 


Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu 
                725                 730                 735     


Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu Gly Ala 
            740                 745                 750         


Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe Thr Asp 
        755                 760                 765             


Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala 
    770                 775                 780                 


Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu 
785                 790                 795                 800 


Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu Phe Tyr 
                805                 810                 815     


Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu Lys Lys 
            820                 825                 830         


Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro 
        835                 840                 845             


Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Glu Ser Glu Pro 
    850                 855                 860                 


Val Thr Ile Asn Ile Gln Asp Leu Leu Ser Cys Ser Asn Phe Ala Val 
865                 870                 875                 880 


Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln 
                885                 890                 895     


Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys 
            900                 905                 910         


His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala 
        915                 920                 925             


Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln 
    930                 935                 940                 


Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
945                 950                 955     


<210>  3
<211>  937
<212>  PRT
<213>  Mus sp.

<400>  3

Met Glu Lys Met Leu Val Gly Cys Leu Leu Met Leu Gly Gln Leu Phe 
1               5                   10                  15      


Leu Val Leu Pro Val Asp Gly Arg Glu Arg Pro Gln Ala Arg Phe Pro 
            20                  25                  30          


Ser Arg Gly Arg His Val Arg Met Tyr Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              


Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  


Ser Arg Ser Val Asn Thr Tyr Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Leu Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      


Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         


Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             


His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 


Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 


Val Pro Arg Ile Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     


Val Ala Glu Val Ala Ala Lys Ala Arg Asn Thr Gly Ile Leu Ile Phe 
            180                 185                 190         


Ala Ile Gly Val Gly Gln Val Asp Leu Asn Thr Leu Lys Ala Ile Gly 
        195                 200                 205             


Ser Glu Pro His Lys Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 


Ile Glu Ser Leu Thr Ser Val Phe Gln Asn Lys Leu Cys Thr Val His 
225                 230                 235                 240 


Met Cys Ser Val Leu Glu His Asn Cys Ala His Phe Cys Leu Asn Thr 
                245                 250                 255     


Pro Gly Ser Tyr Ile Cys Lys Cys Lys Gln Gly Tyr Ile Leu Ser Thr 
            260                 265                 270         


Asp Gln Lys Thr Cys Arg Ile Gln Asp Leu Cys Ala Thr Glu Asp His 
        275                 280                 285             


Gly Cys Glu Gln Leu Cys Val Asn Met Leu Gly Ser Phe Val Cys Gln 
    290                 295                 300                 


Cys Tyr Ser Gly Tyr Thr Leu Ala Glu Asp Gly Lys Arg Cys Thr Ala 
305                 310                 315                 320 


Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     


Asn Ala Glu Ser Ser Tyr Leu Cys Arg Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         


Asn Ser Asp Lys Lys Thr Cys Ser Lys Ile Asp Tyr Cys Ala Ser Ser 
        355                 360                 365             


Asn His Gly Cys Gln His Glu Cys Val Asn Ala Gln Thr Ser Ala Leu 
    370                 375                 380                 


Cys Arg Cys Leu Lys Gly Phe Met Leu Asn Pro Asp Arg Lys Thr Cys 
385                 390                 395                 400 


Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 
                405                 410                 415     


Cys Val Asn Thr Glu Glu Gly His Tyr Cys Arg Cys Arg Gln Gly Tyr 
            420                 425                 430         


Asn Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala 
        435                 440                 445             


Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Glu Ser 
    450                 455                 460                 


Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Asp Asp Leu Lys 
465                 470                 475                 480 


Thr Cys Ser Arg Ala Asp Tyr Cys Leu Leu Ser Asn His Gly Cys Glu 
                485                 490                 495     


Tyr Ser Cys Val Asn Thr Asp Lys Ser Phe Ala Cys Gln Cys Pro Glu 
            500                 505                 510         


Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser 
        515                 520                 525             


Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu 
    530                 535                 540                 


Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Asp Asp 
545                 550                 555                 560 


Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Asp Val Asn His Gly 
                565                 570                 575     


Cys Glu His Leu Cys Val Asn Ser Gly Glu Ser Tyr Val Cys Lys Cys 
            580                 585                 590         


Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys 
        595                 600                 605             


Asn Val Cys Lys Ser Thr Gln His Gly Cys Glu His Met Cys Val Asn 
    610                 615                 620                 


Asn Gly Asn Ser Tyr Leu Cys Arg Cys Ser Glu Gly Phe Val Leu Ala 
625                 630                 635                 640 


Glu Asp Gly Lys His Cys Lys Arg Cys Thr Glu Gly Pro Ile Asp Leu 
                645                 650                 655     


Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu 
            660                 665                 670         


Thr Val Lys His Phe Val Thr Gly Ile Ile Asp Ser Leu Ala Val Ser 
        675                 680                 685             


Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val Arg 
    690                 695                 700                 


Thr Glu Phe Thr Leu Arg Gly Phe Ser Ser Ala Lys Glu Met Lys Lys 
705                 710                 715                 720 


Ala Val Thr His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu 
                725                 730                 735     


Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Val Glu Gly Ala 
            740                 745                 750         


Arg Pro Pro Ser Thr Gln Val Pro Arg Val Ala Ile Val Phe Thr Asp 
        755                 760                 765             


Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala 
    770                 775                 780                 


Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu 
785                 790                 795                 800 


Glu Leu Gln Glu Ile Ala Ser Glu Pro Ile Asp Lys His Leu Phe Tyr 
                805                 810                 815     


Ala Glu Asp Phe Ser Thr Met Gly Glu Ile Ser Glu Lys Leu Lys Glu 
            820                 825                 830         


Gly Ile Cys Glu Ala Leu Glu Asp Ser Gly Gly Arg Gln Asp Ser Ala 
        835                 840                 845             


Ala Trp Asp Leu Pro Gln Gln Ala His Gln Pro Thr Val Gln His Arg 
    850                 855                 860                 


Phe Leu Phe Glu Glu Asp Asn Leu Ser Arg Ser Thr Gln Lys Leu Phe 
865                 870                 875                 880 


His Ser Thr Lys Ser Ser Gly Asn Pro Leu Glu Glu Ser Gln Asp Gln 
                885                 890                 895     


Cys Lys Cys Glu Asn Leu Ile Leu Phe Gln Asn Val Ala Asn Glu Glu 
            900                 905                 910         


Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln Arg Met Glu 
        915                 920                 925             


Ala Leu Glu Asn Arg Leu Lys Tyr Arg 
    930                 935         


<210>  4
<211>  23
<212>  PRT
<213>  Mus sp.

<400>  4

Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu Cys Val Asn 
1               5                   10                  15      


Thr Glu Glu Gly His Tyr Cys 
            20              


<210>  5
<211>  227
<212>  PRT
<213>  Mus sp.

<400>  5

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  6
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  7
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  8
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  9
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  10
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  11
<211>  677
<212>  PRT
<213>  Pan troglodytes

<400>  11

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr 
        35                  40                  45              


Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val 
    50                  55                  60                  


Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala 
65                  70                  75                  80  


Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile 
                85                  90                  95      


Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser 
            100                 105                 110         


Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile 
        115                 120                 125             


Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu 
    130                 135                 140                 


Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp 
145                 150                 155                 160 


Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser 
                165                 170                 175     


Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn 
            180                 185                 190         


Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys 
        195                 200                 205             


Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala 
    210                 215                 220                 


Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys 
225                 230                 235                 240 


Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile 
                245                 250                 255     


Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu 
            260                 265                 270         


Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg 
        275                 280                 285             


Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg 
    290                 295                 300                 


Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr 
305                 310                 315                 320 


Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu 
                325                 330                 335     


Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp 
            340                 345                 350         


Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser 
        355                 360                 365             


Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met 
    370                 375                 380                 


Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu 
385                 390                 395                 400 


Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu 
                405                 410                 415     


Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser 
            420                 425                 430         


Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala 
        435                 440                 445             


His Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro 
    450                 455                 460                 


Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg 
465                 470                 475                 480 


Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala 
                485                 490                 495     


His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys 
            500                 505                 510         


Leu Leu Pro Gln Ala Asn Cys Ser Ile His Thr Ala Pro Pro Ala Glu 
        515                 520                 525             


Ala Gly Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu 
    530                 535                 540                 


Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys 
545                 550                 555                 560 


Pro Pro Met Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His 
                565                 570                 575     


Arg Glu Ala Ser Ile His Ala Ser Cys Cys Arg Ala Pro Gly Leu Glu 
            580                 585                 590         


Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr 
        595                 600                 605             


Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro 
    610                 615                 620                 


Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val 
625                 630                 635                 640 


Val Arg Ser Arg Asp Val Ser Thr Ala Gly Ser Thr Ser Glu Glu Ala 
                645                 650                 655     


Val Ala Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala 
            660                 665                 670         


Ser Gln Glu Leu Gln 
        675         


<210>  12
<211>  694
<212>  PRT
<213>  Mus musculus

<400>  12

Met Gly Thr His Cys Ser Ala Trp Leu Arg Trp Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Pro Pro Leu Leu Leu Leu Leu Leu Leu Leu Cys Pro Thr Gly Ala 
            20                  25                  30          


Gly Ala Gln Asp Glu Asp Gly Asp Tyr Glu Glu Leu Met Leu Ala Leu 
        35                  40                  45              


Pro Ser Gln Glu Asp Gly Leu Ala Asp Glu Ala Ala His Val Ala Thr 
    50                  55                  60                  


Ala Thr Phe Arg Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro Gly Thr 
65                  70                  75                  80  


Tyr Ile Val Val Leu Met Glu Glu Thr Gln Arg Leu Gln Ile Glu Gln 
                85                  90                  95      


Thr Ala His Arg Leu Gln Thr Arg Ala Ala Arg Arg Gly Tyr Val Ile 
            100                 105                 110         


Lys Val Leu His Ile Phe Tyr Asp Leu Phe Pro Gly Phe Leu Val Lys 
        115                 120                 125             


Met Ser Ser Asp Leu Leu Gly Leu Ala Leu Lys Leu Pro His Val Glu 
    130                 135                 140                 


Tyr Ile Glu Glu Asp Ser Phe Val Phe Ala Gln Ser Ile Pro Trp Asn 
145                 150                 155                 160 


Leu Glu Arg Ile Ile Pro Ala Trp His Gln Thr Glu Glu Asp Arg Ser 
                165                 170                 175     


Pro Asp Gly Ser Ser Gln Val Glu Val Tyr Leu Leu Asp Thr Ser Ile 
            180                 185                 190         


Gln Gly Ala His Arg Glu Ile Glu Gly Arg Val Thr Ile Thr Asp Phe 
        195                 200                 205             


Asn Ser Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser 
    210                 215                 220                 


Lys Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg 
225                 230                 235                 240 


Asp Ala Gly Val Ala Lys Gly Thr Ser Leu His Ser Leu Arg Val Leu 
                245                 250                 255     


Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu 
            260                 265                 270         


Phe Ile Arg Lys Ser Gln Leu Ile Gln Pro Ser Gly Pro Leu Val Val 
        275                 280                 285             


Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Ile Leu Asn Ala Ala Cys 
    290                 295                 300                 


Arg His Leu Ala Arg Thr Gly Val Val Leu Val Ala Ala Ala Gly Asn 
305                 310                 315                 320 


Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val 
                325                 330                 335     


Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly 
            340                 345                 350         


Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly 
        355                 360                 365             


Lys Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Met Ser 
    370                 375                 380                 


Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Val Ala 
385                 390                 395                 400 


Arg Met Leu Ser Arg Glu Pro Thr Leu Thr Leu Ala Glu Leu Arg Gln 
                405                 410                 415     


Arg Leu Ile His Phe Ser Thr Lys Asp Val Ile Asn Met Ala Trp Phe 
            420                 425                 430         


Pro Glu Asp Gln Gln Val Leu Thr Pro Asn Leu Val Ala Thr Leu Pro 
        435                 440                 445             


Pro Ser Thr His Glu Thr Gly Gly Gln Leu Leu Cys Arg Thr Val Trp 
    450                 455                 460                 


Ser Ala His Ser Gly Pro Thr Arg Thr Ala Thr Ala Thr Ala Arg Cys 
465                 470                 475                 480 


Ala Pro Glu Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly 
                485                 490                 495     


Arg Arg Arg Gly Asp Trp Ile Glu Ala Ile Gly Gly Gln Gln Val Cys 
            500                 505                 510         


Lys Ala Leu Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Val Ala Arg 
        515                 520                 525             


Cys Cys Leu Val Pro Arg Ala Asn Cys Ser Ile His Asn Thr Pro Ala 
    530                 535                 540                 


Ala Arg Ala Gly Leu Glu Thr His Val His Cys His Gln Lys Asp His 
545                 550                 555                 560 


Val Leu Thr Gly Cys Ser Phe His Trp Glu Val Glu Asp Leu Ser Val 
                565                 570                 575     


Arg Arg Gln Pro Ala Leu Arg Ser Arg Arg Gln Pro Gly Gln Cys Val 
            580                 585                 590         


Gly His Gln Ala Ala Ser Val Tyr Ala Ser Cys Cys His Ala Pro Gly 
        595                 600                 605             


Leu Glu Cys Lys Ile Lys Glu His Gly Ile Ser Gly Pro Ser Glu Gln 
    610                 615                 620                 


Val Thr Val Ala Cys Glu Ala Gly Trp Thr Leu Thr Gly Cys Asn Val 
625                 630                 635                 640 


Leu Pro Gly Ala Ser Leu Thr Leu Gly Ala Tyr Ser Val Asp Asn Leu 
                645                 650                 655     


Cys Val Ala Arg Val His Asp Thr Ala Arg Ala Asp Arg Thr Ser Gly 
            660                 665                 670         


Glu Ala Thr Val Ala Ala Ala Ile Cys Cys Arg Ser Arg Pro Ser Ala 
        675                 680                 685             


Lys Ala Ser Trp Val Gln 
    690                 


<210>  13
<211>  691
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Gly Ile Arg Cys Ser Thr Trp Leu Arg Trp Pro Leu Ser Pro Gln 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Cys Pro Thr Gly Ser Arg Ala Gln Asp 
            20                  25                  30          


Glu Asp Gly Asp Tyr Glu Glu Leu Met Leu Ala Leu Pro Ser Gln Glu 
        35                  40                  45              


Asp Ser Leu Val Asp Glu Ala Ser His Val Ala Thr Ala Thr Phe Arg 
    50                  55                  60                  


Arg Cys Ser Lys Glu Ala Trp Arg Leu Pro Gly Thr Tyr Val Val Val 
65                  70                  75                  80  


Leu Met Glu Glu Thr Gln Arg Leu Gln Val Glu Gln Thr Ala His Arg 
                85                  90                  95      


Leu Gln Thr Trp Ala Ala Arg Arg Gly Tyr Val Ile Lys Val Leu His 
            100                 105                 110         


Val Phe Tyr Asp Leu Phe Pro Gly Phe Leu Val Lys Met Ser Ser Asp 
        115                 120                 125             


Leu Leu Gly Leu Ala Leu Lys Leu Pro His Val Glu Tyr Ile Glu Glu 
    130                 135                 140                 


Asp Ser Leu Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg Ile 
145                 150                 155                 160 


Ile Pro Ala Trp Gln Gln Thr Glu Glu Asp Ser Ser Pro Asp Gly Ser 
                165                 170                 175     


Ser Gln Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Gly His 
            180                 185                 190         


Arg Glu Ile Glu Gly Arg Val Thr Ile Thr Asp Phe Asn Ser Val Pro 
        195                 200                 205             


Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp Ser 
    210                 215                 220                 


His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly Val 
225                 230                 235                 240 


Ala Lys Gly Thr Ser Leu His Ser Leu Arg Val Leu Asn Cys Gln Gly 
                245                 250                 255     


Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg Lys 
            260                 265                 270         


Ser Gln Leu Ile Gln Pro Ser Gly Pro Leu Val Val Leu Leu Pro Leu 
        275                 280                 285             


Ala Gly Gly Tyr Ser Arg Ile Leu Asn Thr Ala Cys Gln Arg Leu Ala 
    290                 295                 300                 


Arg Thr Gly Val Val Leu Val Ala Ala Ala Gly Asn Phe Arg Asp Asp 
305                 310                 315                 320 


Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val Gly 
                325                 330                 335     


Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly Thr 
            340                 345                 350         


Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Lys Asp Ile Ile 
        355                 360                 365             


Gly Ala Ser Ser Asp Cys Ser Thr Cys Tyr Met Ser Gln Ser Gly Thr 
    370                 375                 380                 


Ser Gln Ala Ala Ala His Val Ala Gly Ile Val Ala Met Met Leu Asn 
385                 390                 395                 400 


Arg Asp Pro Ala Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile Leu 
                405                 410                 415     


Phe Ser Thr Lys Asp Val Ile Asn Met Ala Trp Phe Pro Glu Asp Gln 
            420                 425                 430         


Arg Val Leu Thr Pro Asn Arg Val Ala Thr Leu Pro Pro Ser Thr Gln 
        435                 440                 445             


Glu Thr Gly Gly Gln Leu Leu Cys Arg Thr Val Trp Ser Ala His Ser 
    450                 455                 460                 


Gly Pro Thr Arg Thr Ala Thr Ala Thr Ala Arg Cys Ala Pro Glu Glu 
465                 470                 475                 480 


Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Arg Arg Arg Gly 
                485                 490                 495     


Asp Arg Ile Glu Ala Ile Gly Gly Gln Gln Val Cys Lys Ala Leu Asn 
            500                 505                 510         


Ala Phe Gly Gly Glu Gly Val Tyr Ala Val Ala Arg Cys Cys Leu Leu 
        515                 520                 525             


Pro Arg Val Asn Cys Ser Ile His Asn Thr Pro Ala Ala Arg Ala Gly 
    530                 535                 540                 


Pro Gln Thr Pro Val His Cys His Gln Lys Asp His Val Leu Thr Gly 
545                 550                 555                 560 


Cys Ser Phe His Trp Glu Val Glu Asn Leu Arg Ala Gln Gln Gln Pro 
                565                 570                 575     


Leu Leu Arg Ser Arg His Gln Pro Gly Gln Cys Val Gly His Gln Glu 
            580                 585                 590         


Ala Ser Val His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys Lys 
        595                 600                 605             


Ile Lys Glu His Gly Ile Ala Gly Pro Ala Glu Gln Val Thr Val Ala 
    610                 615                 620                 


Cys Glu Ala Gly Trp Thr Leu Thr Gly Cys Asn Val Leu Pro Gly Ala 
625                 630                 635                 640 


Ser Leu Pro Leu Gly Ala Tyr Ser Val Asp Asn Val Cys Val Ala Arg 
                645                 650                 655     


Ile Arg Asp Ala Gly Arg Ala Asp Arg Thr Ser Glu Glu Ala Thr Val 
            660                 665                 670         


Ala Ala Ala Ile Cys Cys Arg Ser Arg Pro Ser Ala Lys Ala Ser Trp 
        675                 680                 685             


Val His Gln 
    690     


<210>  14
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  14

Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp 
1               5                   10                  15      


Leu 
    


<210>  15
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 
1               5                   10                  15      


Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 
            20                  25                  30          


Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              


Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  


Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      


Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         


Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             


His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 


Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 


Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     


Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
            180                 185                 190         


Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
        195                 200                 205             


Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 


Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
225                 230                 235                 240 


Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
                245                 250                 255     


Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
            260                 265                 270         


Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 
        275                 280                 285             


Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 
    290                 295                 300                 


Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 
305                 310                 315                 320 


Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     


Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         


Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser 
        355                 360                 365             


Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser 
    370                 375                 380                 


Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys 
385                 390                 395                 400 


Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 
                405                 410                 415     


Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr 
            420                 425                 430         


Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala 
        435                 440                 445             


Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Asp Ser 
    450                 455                 460                 


Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp Leu Lys 
465                 470                 475                 480 


Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu 
                485                 490                 495     


Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu 
            500                 505                 510         


Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser 
        515                 520                 525             


Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu 
    530                 535                 540                 


Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp 
545                 550                 555                 560 


Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly 
                565                 570                 575     


Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys 
            580                 585                 590         


Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys 
        595                 600                 605             


Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys Val Asn 
    610                 615                 620                 


Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val Leu Ala 
625                 630                 635                 640 


Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile Asp Leu 
                645                 650                 655     


Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu 
            660                 665                 670         


Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser 
        675                 680                 685             


Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val His 
    690                 695                 700                 


Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met Lys Lys 
705                 710                 715                 720 


Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu 
                725                 730                 735     


Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu Gly Ala 
            740                 745                 750         


Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe Thr Asp 
        755                 760                 765             


Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala 
    770                 775                 780                 


Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu 
785                 790                 795                 800 


Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu Phe Tyr 
                805                 810                 815     


Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu Lys Lys 
            820                 825                 830         


Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro 
        835                 840                 845             


Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Val Gln His Arg 
    850                 855                 860                 


Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln Lys Leu Ser 
865                 870                 875                 880 


His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys His Asp Gln 
                885                 890                 895     


Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala Asn Glu Glu 
            900                 905                 910         


Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln Arg Met Glu 
        915                 920                 925             


Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
    930                 935         


<210>  16
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Val Ala Gly Arg Asn Arg Pro Gly Ala Ala Trp Ala Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Ala Gly Ala Val 
            20                  25                  30          


Pro Pro Gly Arg Gly Arg Ala Ala Gly Pro Gln Glu Asp Val Asp Glu 
        35                  40                  45              


Cys Ala Gln Gly Leu Asp Asp Cys His Ala Asp Ala Leu Cys Gln Asn 
    50                  55                  60                  


Thr Pro Thr Ser Tyr Lys Cys Ser Cys Lys Pro Gly Tyr Gln Gly Glu 
65                  70                  75                  80  


Gly Arg Gln Cys Glu Asp Ile Asp Glu Cys Gly Asn Glu Leu Asn Gly 
                85                  90                  95      


Gly Cys Val His Asp Cys Leu Asn Ile Pro Gly Asn Tyr Arg Cys Thr 
            100                 105                 110         


Cys Phe Asp Gly Phe Met Leu Ala His Asp Gly His Asn Cys Leu Asp 
        115                 120                 125             


Val Asp Glu Cys Leu Glu Asn Asn Gly Gly Cys Gln His Thr Cys Val 
    130                 135                 140                 


Asn Val Met Gly Ser Tyr Glu Cys Cys Cys Lys Glu Gly Phe Phe Leu 
145                 150                 155                 160 


Ser Asp Asn Gln His Thr Cys Ile His Arg Ser Glu Glu Gly Leu Ser 
                165                 170                 175     


Cys Met Asn Lys Asp His Gly Cys Ser His Ile Cys Lys Glu Ala Pro 
            180                 185                 190         


Arg Gly Ser Val Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Ala Lys 
        195                 200                 205             


Asn Gln Arg Asp Cys Ile Leu Thr Cys Asn His Gly Asn Gly Gly Cys 
    210                 215                 220                 


Gln His Ser Cys Asp Asp Thr Ala Asp Gly Pro Glu Cys Ser Cys His 
225                 230                 235                 240 


Pro Gln Tyr Lys Met His Thr Asp Gly Arg Ser Cys Leu Glu Arg Glu 
                245                 250                 255     


Asp Thr Val Leu Glu Val Thr Glu Ser Asn Thr Thr Ser Val Val Asp 
            260                 265                 270         


Gly Asp Lys Arg Val Lys Arg Arg Leu Leu Met Glu Thr Cys Ala Val 
        275                 280                 285             


Asn Asn Gly Gly Cys Asp Arg Thr Cys Lys Asp Thr Ser Thr Gly Val 
    290                 295                 300                 


His Cys Ser Cys Pro Val Gly Phe Thr Leu Gln Leu Asp Gly Lys Thr 
305                 310                 315                 320 


Cys Lys Asp Ile Asp Glu Cys Gln Thr Arg Asn Gly Gly Cys Asp His 
                325                 330                 335     


Phe Cys Lys Asn Ile Val Gly Ser Phe Asp Cys Gly Cys Lys Lys Gly 
            340                 345                 350         


Phe Lys Leu Leu Thr Asp Glu Lys Ser Cys Gln Asp Val Asp Glu Cys 
        355                 360                 365             


Ser Leu Asp Arg Thr Cys Asp His Ser Cys Ile Asn His Pro Gly Thr 
    370                 375                 380                 


Phe Ala Cys Ala Cys Asn Arg Gly Tyr Thr Leu Tyr Gly Phe Thr His 
385                 390                 395                 400 


Cys Gly Asp Thr Asn Glu Cys Ser Ile Asn Asn Gly Gly Cys Gln Gln 
                405                 410                 415     


Val Cys Val Asn Thr Val Gly Ser Tyr Glu Cys Gln Cys His Pro Gly 
            420                 425                 430         


Tyr Lys Leu His Trp Asn Lys Lys Asp Cys Val Glu Val Lys Gly Leu 
        435                 440                 445             


Leu Pro Thr Ser Val Ser Pro Arg Val Ser Leu His Cys Gly Lys Ser 
    450                 455                 460                 


Gly Gly Gly Asp Gly Cys Phe Leu Arg Cys His Ser Gly Ile His Leu 
465                 470                 475                 480 


Ser Ser Asp Val Thr Thr Ile Arg Thr Ser Val Thr Phe Lys Leu Asn 
                485                 490                 495     


Glu Gly Lys Cys Ser Leu Lys Asn Ala Glu Leu Phe Pro Glu Gly Leu 
            500                 505                 510         


Arg Pro Ala Leu Pro Glu Lys His Ser Ser Val Lys Glu Ser Phe Arg 
        515                 520                 525             


Tyr Val Asn Leu Thr Cys Ser Ser Gly Lys Gln Val Pro Gly Ala Pro 
    530                 535                 540                 


Gly Arg Pro Ser Thr Pro Lys Glu Met Phe Ile Thr Val Glu Phe Glu 
545                 550                 555                 560 


Leu Glu Thr Asn Gln Lys Glu Val Thr Ala Ser Cys Asp Leu Ser Cys 
                565                 570                 575     


Ile Val Lys Arg Thr Glu Lys Arg Leu Arg Lys Ala Ile Arg Thr Leu 
            580                 585                 590         


Arg Lys Ala Val His Arg Glu Gln Phe His Leu Gln Leu Ser Gly Met 
        595                 600                 605             


Asn Leu Asp Val Ala Lys Lys Pro Pro Arg Thr Ser Glu Arg Gln Ala 
    610                 615                 620                 


Glu Ser Cys Gly Val Gly Gln Gly His Ala Glu Asn Gln Cys Val Ser 
625                 630                 635                 640 


Cys Arg Ala Gly Thr Tyr Tyr Asp Gly Ala Arg Glu Arg Cys Ile Leu 
                645                 650                 655     


Cys Pro Asn Gly Thr Phe Gln Asn Glu Glu Gly Gln Met Thr Cys Glu 
            660                 665                 670         


Pro Cys Pro Arg Pro Gly Asn Ser Gly Ala Leu Lys Thr Pro Glu Ala 
        675                 680                 685             


Trp Asn Met Ser Glu Cys Gly Gly Leu Cys Gln Pro Gly Glu Tyr Ser 
    690                 695                 700                 


Ala Asp Gly Phe Ala Pro Cys Gln Leu Cys Ala Leu Gly Thr Phe Gln 
705                 710                 715                 720 


Pro Glu Ala Gly Arg Thr Ser Cys Phe Pro Cys Gly Gly Gly Leu Ala 
                725                 730                 735     


Thr Lys His Gln Gly Ala Thr Ser Phe Gln Asp Cys Glu Thr Arg Val 
            740                 745                 750         


Gln Cys Ser Pro Gly His Phe Tyr Asn Thr Thr Thr His Arg Cys Ile 
        755                 760                 765             


Arg Cys Pro Val Gly Thr Tyr Gln Pro Glu Phe Gly Lys Asn Asn Cys 
    770                 775                 780                 


Val Ser Cys Pro Gly Asn Thr Thr Thr Asp Phe Asp Gly Ser Thr Asn 
785                 790                 795                 800 


Ile Thr Gln Cys Lys Asn Arg Arg Cys Gly Gly Glu Leu Gly Asp Phe 
                805                 810                 815     


Thr Gly Tyr Ile Glu Ser Pro Asn Tyr Pro Gly Asn Tyr Pro Ala Asn 
            820                 825                 830         


Thr Glu Cys Thr Trp Thr Ile Asn Pro Pro Pro Lys Arg Arg Ile Leu 
        835                 840                 845             


Ile Val Val Pro Glu Ile Phe Leu Pro Ile Glu Asp Asp Cys Gly Asp 
    850                 855                 860                 


Tyr Leu Val Met Arg Lys Thr Ser Ser Ser Asn Ser Val Thr Thr Tyr 
865                 870                 875                 880 


Glu Thr Cys Gln Thr Tyr Glu Arg Pro Ile Ala Phe Thr Ser Arg Ser 
                885                 890                 895     


Lys Lys Leu Trp Ile Gln Phe Lys Ser Asn Glu Gly Asn Ser Ala Arg 
            900                 905                 910         


Gly Phe Gln Val Pro Tyr Val Thr Tyr Asp Glu Asp Tyr Gln Glu Leu 
        915                 920                 925             


Ile Glu Asp Ile Val Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His 
    930                 935                 940                 


Gln Glu Ile Leu Lys Asp Lys Lys Leu Ile Lys Ala Leu Phe Asp Val 
945                 950                 955                 960 


Leu Ala His Pro Gln Asn Tyr Phe Lys Tyr Thr Ala Gln Glu Ser Arg 
                965                 970                 975     


Glu Met Phe Pro Arg Ser Phe Ile Arg Leu Leu Arg Ser Lys Val Ser 
            980                 985                 990         


Arg Phe Leu Arg Pro Tyr Lys 
        995                 


<210>  17
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Pro Phe Leu Leu Leu Thr Cys Leu Phe Ile Thr Gly Thr Ser 
1               5                   10                  15      


Val Ser Pro Val Ala Leu Asp Pro Cys Ser Ala Tyr Ile Ser Leu Asn 
            20                  25                  30          


Glu Pro Trp Arg Asn Thr Asp His Gln Leu Asp Glu Ser Gln Gly Pro 
        35                  40                  45              


Pro Leu Cys Asp Asn His Val Asn Gly Glu Trp Tyr His Phe Thr Gly 
    50                  55                  60                  


Met Ala Gly Asp Ala Met Pro Thr Phe Cys Ile Pro Glu Asn His Cys 
65                  70                  75                  80  


Gly Thr His Ala Pro Val Trp Leu Asn Gly Ser His Pro Leu Glu Gly 
                85                  90                  95      


Asp Gly Ile Val Gln Arg Gln Ala Cys Ala Ser Phe Asn Gly Asn Cys 
            100                 105                 110         


Cys Leu Trp Asn Thr Thr Val Glu Val Lys Ala Cys Pro Gly Gly Tyr 
        115                 120                 125             


Tyr Val Tyr Arg Leu Thr Lys Pro Ser Val Cys Phe His Val Tyr Cys 
    130                 135                 140                 


Gly His Phe Tyr Asp Ile Cys Asp Glu Asp Cys His Gly Ser Cys Ser 
145                 150                 155                 160 


Asp Thr Ser Glu Cys Thr Cys Ala Pro Gly Thr Val Leu Gly Pro Asp 
                165                 170                 175     


Arg Gln Thr Cys Phe Asp Glu Asn Glu Cys Glu Gln Asn Asn Gly Gly 
            180                 185                 190         


Cys Ser Glu Ile Cys Val Asn Leu Lys Asn Ser Tyr Arg Cys Glu Cys 
        195                 200                 205             


Gly Val Gly Arg Val Leu Arg Ser Asp Gly Lys Thr Cys Glu Asp Val 
    210                 215                 220                 


Glu Gly Cys His Asn Asn Asn Gly Gly Cys Ser His Ser Cys Leu Gly 
225                 230                 235                 240 


Ser Glu Lys Gly Tyr Gln Cys Glu Cys Pro Arg Gly Leu Val Leu Ser 
                245                 250                 255     


Glu Asp Asn His Thr Cys Gln Val Pro Val Leu Cys Lys Ser Asn Ala 
            260                 265                 270         


Ile Glu Val Asn Ile Pro Arg Glu Leu Val Gly Gly Leu Glu Leu Phe 
        275                 280                 285             


Leu Thr Asn Thr Ser Cys Arg Gly Val Ser Asn Gly Thr His Val Asn 
    290                 295                 300                 


Ile Leu Phe Ser Leu Lys Thr Cys Gly Thr Val Val Asp Val Val Asn 
305                 310                 315                 320 


Asp Lys Ile Val Ala Ser Asn Leu Val Thr Gly Leu Pro Lys Gln Thr 
                325                 330                 335     


Pro Gly Ser Ser Gly Asp Phe Ile Ile Arg Thr Ser Lys Leu Leu Ile 
            340                 345                 350         


Pro Val Thr Cys Glu Phe Pro Arg Leu Tyr Thr Ile Ser Glu Gly Tyr 
        355                 360                 365             


Val Pro Asn Leu Arg Asn Ser Pro Leu Glu Ile Met Ser Arg Asn His 
    370                 375                 380                 


Gly Ile Phe Pro Phe Thr Leu Glu Ile Phe Lys Asp Asn Glu Phe Glu 
385                 390                 395                 400 


Glu Pro Tyr Arg Glu Ala Leu Pro Thr Leu Lys Leu Arg Asp Ser Leu 
                405                 410                 415     


Tyr Phe Gly Ile Glu Pro Val Val His Val Ser Gly Leu Glu Ser Leu 
            420                 425                 430         


Val Glu Ser Cys Phe Ala Thr Pro Thr Ser Lys Ile Asp Glu Val Leu 
        435                 440                 445             


Lys Tyr Tyr Leu Ile Arg Asp Gly Cys Val Ser Asp Asp Ser Val Lys 
    450                 455                 460                 


Gln Tyr Thr Ser Arg Asp His Leu Ala Lys His Phe Gln Val Pro Val 
465                 470                 475                 480 


Phe Lys Phe Val Gly Lys Asp His Lys Glu Val Phe Leu His Cys Arg 
                485                 490                 495     


Val Leu Val Cys Gly Val Leu Asp Glu Arg Ser Arg Cys Ala Gln Gly 
            500                 505                 510         


Cys His Arg Arg Met Arg Arg Gly Ala Gly Gly Glu Asp Ser Ala Gly 
        515                 520                 525             


Leu Gln Gly Gln Thr Leu Thr Gly Gly Pro Ile Arg Ile Asp Trp Glu 
    530                 535                 540                 


Asp 
545 


<210>  18
<211>  988
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Ala Ala Ala Val Arg Trp His Leu Cys Val Leu Leu Ala Leu 
1               5                   10                  15      


Gly Thr Arg Gly Arg Leu Ala Gly Gly Ser Gly Leu Pro Gly Ser Val 
            20                  25                  30          


Asp Val Asp Glu Cys Ser Glu Gly Thr Asp Asp Cys His Ile Asp Ala 
        35                  40                  45              


Ile Cys Gln Asn Thr Pro Lys Ser Tyr Lys Cys Leu Cys Lys Pro Gly 
    50                  55                  60                  


Tyr Lys Gly Glu Gly Lys Gln Cys Glu Asp Ile Asp Glu Cys Glu Asn 
65                  70                  75                  80  


Asp Tyr Tyr Asn Gly Gly Cys Val His Glu Cys Ile Asn Ile Pro Gly 
                85                  90                  95      


Asn Tyr Arg Cys Thr Cys Phe Asp Gly Phe Met Leu Ala His Asp Gly 
            100                 105                 110         


His Asn Cys Leu Asp Val Asp Glu Cys Gln Asp Asn Asn Gly Gly Cys 
        115                 120                 125             


Gln Gln Ile Cys Val Asn Ala Met Gly Ser Tyr Glu Cys Gln Cys His 
    130                 135                 140                 


Ser Gly Phe Phe Leu Ser Asp Asn Gln His Thr Cys Ile His Arg Ser 
145                 150                 155                 160 


Asn Glu Gly Met Asn Cys Met Asn Lys Asp His Gly Cys Ala His Ile 
                165                 170                 175     


Cys Arg Glu Thr Pro Lys Gly Gly Val Ala Cys Asp Cys Arg Pro Gly 
            180                 185                 190         


Phe Asp Leu Ala Gln Asn Gln Lys Asp Cys Thr Leu Thr Cys Asn Tyr 
        195                 200                 205             


Gly Asn Gly Gly Cys Gln His Ser Cys Glu Asp Thr Asp Thr Gly Pro 
    210                 215                 220                 


Thr Cys Gly Cys His Gln Lys Tyr Ala Leu His Ser Asp Gly Arg Thr 
225                 230                 235                 240 


Cys Ile Glu Thr Cys Ala Val Asn Asn Gly Gly Cys Asp Arg Thr Cys 
                245                 250                 255     


Lys Asp Thr Ala Thr Gly Val Arg Cys Ser Cys Pro Val Gly Phe Thr 
            260                 265                 270         


Leu Gln Pro Asp Gly Lys Thr Cys Lys Asp Ile Asn Glu Cys Leu Val 
        275                 280                 285             


Asn Asn Gly Gly Cys Asp His Phe Cys Arg Asn Thr Val Gly Ser Phe 
    290                 295                 300                 


Glu Cys Gly Cys Arg Lys Gly Tyr Lys Leu Leu Thr Asp Glu Arg Thr 
305                 310                 315                 320 


Cys Gln Asp Ile Asp Glu Cys Ser Phe Glu Arg Thr Cys Asp His Ile 
                325                 330                 335     


Cys Ile Asn Ser Pro Gly Ser Phe Gln Cys Leu Cys His Arg Gly Tyr 
            340                 345                 350         


Ile Leu Tyr Gly Thr Thr His Cys Gly Asp Val Asp Glu Cys Ser Met 
        355                 360                 365             


Ser Asn Gly Ser Cys Asp Gln Gly Cys Val Asn Thr Lys Gly Ser Tyr 
    370                 375                 380                 


Glu Cys Val Cys Pro Pro Gly Arg Arg Leu His Trp Asn Gly Lys Asp 
385                 390                 395                 400 


Cys Val Glu Thr Gly Lys Cys Leu Ser Arg Ala Lys Thr Ser Pro Arg 
                405                 410                 415     


Ala Gln Leu Ser Cys Ser Lys Ala Gly Gly Val Glu Ser Cys Phe Leu 
            420                 425                 430         


Ser Cys Pro Ala His Thr Leu Phe Val Pro Asp Ser Glu Asn Ser Tyr 
        435                 440                 445             


Val Leu Ser Cys Gly Val Pro Gly Pro Gln Gly Lys Ala Leu Gln Lys 
    450                 455                 460                 


Arg Asn Gly Thr Ser Ser Gly Leu Gly Pro Ser Cys Ser Asp Ala Pro 
465                 470                 475                 480 


Thr Thr Pro Ile Lys Gln Lys Ala Arg Phe Lys Ile Arg Asp Ala Lys 
                485                 490                 495     


Cys His Leu Arg Pro His Ser Gln Ala Arg Ala Lys Glu Thr Ala Arg 
            500                 505                 510         


Gln Pro Leu Leu Asp His Cys His Val Thr Phe Val Thr Leu Lys Cys 
        515                 520                 525             


Asp Ser Ser Lys Lys Arg Arg Arg Gly Arg Lys Ser Pro Ser Lys Glu 
    530                 535                 540                 


Val Ser His Ile Thr Ala Glu Phe Glu Ile Glu Thr Lys Met Glu Glu 
545                 550                 555                 560 


Ala Ser Asp Thr Cys Glu Ala Asp Cys Leu Arg Lys Arg Ala Glu Gln 
                565                 570                 575     


Ser Leu Gln Ala Ala Ile Lys Thr Leu Arg Lys Ser Ile Gly Arg Gln 
            580                 585                 590         


Gln Phe Tyr Val Gln Val Ser Gly Thr Glu Tyr Glu Val Ala Gln Arg 
        595                 600                 605             


Pro Ala Lys Ala Leu Glu Gly Gln Gly Ala Cys Gly Ala Gly Gln Val 
    610                 615                 620                 


Leu Gln Asp Ser Lys Cys Val Ala Cys Gly Pro Gly Thr His Phe Gly 
625                 630                 635                 640 


Gly Glu Leu Gly Gln Cys Val Ser Cys Met Pro Gly Thr Tyr Gln Asp 
                645                 650                 655     


Met Glu Gly Gln Leu Ser Cys Thr Pro Cys Pro Ser Ser Asp Gly Leu 
            660                 665                 670         


Gly Leu Pro Gly Ala Arg Asn Val Ser Glu Cys Gly Gly Gln Cys Ser 
        675                 680                 685             


Pro Gly Phe Phe Ser Ala Asp Gly Phe Lys Pro Cys Gln Ala Cys Pro 
    690                 695                 700                 


Val Gly Thr Tyr Gln Pro Glu Pro Gly Arg Thr Gly Cys Phe Pro Cys 
705                 710                 715                 720 


Gly Gly Gly Leu Leu Thr Lys His Glu Gly Thr Thr Ser Phe Gln Asp 
                725                 730                 735     


Cys Glu Ala Lys Val His Cys Ser Pro Gly His His Tyr Asn Thr Thr 
            740                 745                 750         


Thr His Arg Cys Ile Arg Cys Pro Val Gly Thr Tyr Gln Pro Glu Phe 
        755                 760                 765             


Gly Gln Asn His Cys Ile Thr Cys Pro Gly Asn Thr Ser Thr Asp Phe 
    770                 775                 780                 


Asp Gly Ser Thr Asn Val Thr His Cys Lys Asn Gln His Cys Gly Gly 
785                 790                 795                 800 


Glu Leu Gly Asp Tyr Thr Gly Tyr Ile Glu Ser Pro Asn Tyr Pro Gly 
                805                 810                 815     


Asp Tyr Pro Ala Asn Ala Glu Cys Val Trp His Ile Ala Pro Pro Pro 
            820                 825                 830         


Lys Arg Arg Ile Leu Ile Val Val Pro Glu Ile Phe Leu Pro Ile Glu 
        835                 840                 845             


Asp Glu Cys Gly Asp Val Leu Val Met Arg Lys Ser Ala Ser Pro Thr 
    850                 855                 860                 


Ser Ile Thr Thr Tyr Glu Thr Cys Gln Thr Tyr Glu Arg Pro Ile Ala 
865                 870                 875                 880 


Phe Thr Ser Arg Ser Arg Lys Leu Trp Ile Gln Phe Lys Ser Asn Glu 
                885                 890                 895     


Gly Asn Ser Gly Lys Gly Phe Gln Val Pro Tyr Val Thr Tyr Asp Glu 
            900                 905                 910         


Asp Tyr Gln Gln Leu Ile Glu Asp Ile Val Arg Asp Gly Arg Leu Tyr 
        915                 920                 925             


Ala Ser Glu Asn His Gln Glu Ile Leu Lys Asp Lys Lys Leu Ile Lys 
    930                 935                 940                 


Ala Leu Phe Asp Val Leu Ala His Pro Gln Asn Tyr Phe Lys Tyr Thr 
945                 950                 955                 960 


Ala Gln Glu Ser Lys Glu Met Phe Pro Arg Ser Phe Ile Lys Leu Leu 
                965                 970                 975     


Arg Ser Lys Val Ser Arg Phe Leu Arg Pro Tyr Lys 
            980                 985             


<210>  19
<211>  4544
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Gln  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210>  20
<211>  4655
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210>  21
<211>  1905
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Arg Gln Trp Gly Ala Leu Leu Leu Gly Ala Leu Leu Cys Ala 
1               5                   10                  15      


His Gly Leu Ala Ser Ser Pro Glu Cys Ala Cys Gly Arg Ser His Phe 
            20                  25                  30          


Thr Cys Ala Val Ser Ala Leu Gly Glu Cys Thr Cys Ile Pro Ala Gln 
        35                  40                  45              


Trp Gln Cys Asp Gly Asp Asn Asp Cys Gly Asp His Ser Asp Glu Asp 
    50                  55                  60                  


Gly Cys Ile Leu Pro Thr Cys Ser Pro Leu Asp Phe His Cys Asp Asn 
65                  70                  75                  80  


Gly Lys Cys Ile Arg Arg Ser Trp Val Cys Asp Gly Asp Asn Asp Cys 
                85                  90                  95      


Glu Asp Asp Ser Asp Glu Gln Asp Cys Pro Pro Arg Glu Cys Glu Glu 
            100                 105                 110         


Asp Glu Phe Pro Cys Gln Asn Gly Tyr Cys Ile Arg Ser Leu Trp His 
        115                 120                 125             


Cys Asp Gly Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu Gln Cys Asp 
    130                 135                 140                 


Met Arg Lys Cys Ser Asp Lys Glu Phe Arg Cys Ser Asp Gly Ser Cys 
145                 150                 155                 160 


Ile Ala Glu His Trp Tyr Cys Asp Gly Asp Thr Asp Cys Lys Asp Gly 
                165                 170                 175     


Ser Asp Glu Glu Asn Cys Pro Ser Ala Val Pro Ala Pro Pro Cys Asn 
            180                 185                 190         


Leu Glu Glu Phe Gln Cys Ala Tyr Gly Arg Cys Ile Leu Asp Ile Tyr 
        195                 200                 205             


His Cys Asp Gly Asp Asp Asp Cys Gly Asp Trp Ser Asp Glu Ser Asp 
    210                 215                 220                 


Cys Ser Ser His Gln Pro Cys Arg Ser Gly Glu Phe Met Cys Asp Ser 
225                 230                 235                 240 


Gly Leu Cys Ile Asn Ala Gly Trp Arg Cys Asp Gly Asp Ala Asp Cys 
                245                 250                 255     


Asp Asp Gln Ser Asp Glu Arg Asn Cys Thr Thr Ser Met Cys Thr Ala 
            260                 265                 270         


Glu Gln Phe Arg Cys His Ser Gly Arg Cys Val Arg Leu Ser Trp Arg 
        275                 280                 285             


Cys Asp Gly Glu Asp Asp Cys Ala Asp Asn Ser Asp Glu Glu Asn Cys 
    290                 295                 300                 


Glu Asn Thr Gly Ser Pro Gln Cys Ala Leu Asp Gln Phe Leu Cys Trp 
305                 310                 315                 320 


Asn Gly Arg Cys Ile Gly Gln Arg Lys Leu Cys Asn Gly Val Asn Asp 
                325                 330                 335     


Cys Gly Asp Asn Ser Asp Glu Ser Pro Gln Gln Asn Cys Arg Pro Arg 
            340                 345                 350         


Thr Gly Glu Glu Asn Cys Asn Val Asn Asn Gly Gly Cys Ala Gln Lys 
        355                 360                 365             


Cys Gln Met Val Arg Gly Ala Val Gln Cys Thr Cys His Thr Gly Tyr 
    370                 375                 380                 


Arg Leu Thr Glu Asp Gly His Thr Cys Gln Asp Val Asn Glu Cys Ala 
385                 390                 395                 400 


Glu Glu Gly Tyr Cys Ser Gln Gly Cys Thr Asn Ser Glu Gly Ala Phe 
                405                 410                 415     


Gln Cys Trp Cys Glu Thr Gly Tyr Glu Leu Arg Pro Asp Arg Arg Ser 
            420                 425                 430         


Cys Lys Ala Leu Gly Pro Glu Pro Val Leu Leu Phe Ala Asn Arg Ile 
        435                 440                 445             


Asp Ile Arg Gln Val Leu Pro His Arg Ser Glu Tyr Thr Leu Leu Leu 
    450                 455                 460                 


Asn Asn Leu Glu Asn Ala Ile Ala Leu Asp Phe His His Arg Arg Glu 
465                 470                 475                 480 


Leu Val Phe Trp Ser Asp Val Thr Leu Asp Arg Ile Leu Arg Ala Asn 
                485                 490                 495     


Leu Asn Gly Ser Asn Val Glu Glu Val Val Ser Thr Gly Leu Glu Ser 
            500                 505                 510         


Pro Gly Gly Leu Ala Val Asp Trp Val His Asp Lys Leu Tyr Trp Thr 
        515                 520                 525             


Asp Ser Gly Thr Ser Arg Ile Glu Val Ala Asn Leu Asp Gly Ala His 
    530                 535                 540                 


Arg Lys Val Leu Leu Trp Gln Asn Leu Glu Lys Pro Arg Ala Ile Ala 
545                 550                 555                 560 


Leu His Pro Met Glu Gly Thr Ile Tyr Trp Thr Asp Trp Gly Asn Thr 
                565                 570                 575     


Pro Arg Ile Glu Ala Ser Ser Met Asp Gly Ser Gly Arg Arg Ile Ile 
            580                 585                 590         


Ala Asp Thr His Leu Phe Trp Pro Asn Gly Leu Thr Ile Asp Tyr Ala 
        595                 600                 605             


Gly Arg Arg Met Tyr Trp Val Asp Ala Lys His His Val Ile Glu Arg 
    610                 615                 620                 


Ala Asn Leu Asp Gly Ser His Arg Lys Ala Val Ile Ser Gln Gly Leu 
625                 630                 635                 640 


Pro His Pro Phe Ala Ile Thr Val Phe Glu Asp Ser Leu Tyr Trp Thr 
                645                 650                 655     


Asp Trp His Thr Lys Ser Ile Asn Ser Ala Asn Lys Phe Thr Gly Lys 
            660                 665                 670         


Asn Gln Glu Ile Ile Arg Asn Lys Leu His Phe Pro Met Asp Ile His 
        675                 680                 685             


Thr Leu His Pro Gln Arg Gln Pro Ala Gly Lys Asn Arg Cys Gly Asp 
    690                 695                 700                 


Asn Asn Gly Gly Cys Thr His Leu Cys Leu Pro Ser Gly Gln Asn Tyr 
705                 710                 715                 720 


Thr Cys Ala Cys Pro Thr Gly Phe Arg Lys Ile Ser Ser His Ala Cys 
                725                 730                 735     


Ala Gln Ser Leu Asp Lys Phe Leu Leu Phe Ala Arg Arg Met Asp Ile 
            740                 745                 750         


Arg Arg Ile Ser Phe Asp Thr Glu Asp Leu Ser Asp Asp Val Ile Pro 
        755                 760                 765             


Leu Ala Asp Val Arg Ser Ala Val Ala Leu Asp Trp Asp Ser Arg Asp 
    770                 775                 780                 


Asp His Val Tyr Trp Thr Asp Val Ser Thr Asp Thr Ile Ser Arg Ala 
785                 790                 795                 800 


Lys Trp Asp Gly Thr Gly Gln Glu Val Val Val Asp Thr Ser Leu Glu 
                805                 810                 815     


Ser Pro Ala Gly Leu Ala Ile Asp Trp Val Thr Asn Lys Leu Tyr Trp 
            820                 825                 830         


Thr Asp Ala Gly Thr Asp Arg Ile Glu Val Ala Asn Thr Asp Gly Ser 
        835                 840                 845             


Met Arg Thr Val Leu Ile Trp Glu Asn Leu Asp Arg Pro Arg Asp Ile 
    850                 855                 860                 


Val Val Glu Pro Met Gly Gly Tyr Met Tyr Trp Thr Asp Trp Gly Ala 
865                 870                 875                 880 


Ser Pro Lys Ile Glu Arg Ala Gly Met Asp Ala Ser Gly Arg Gln Val 
                885                 890                 895     


Ile Ile Ser Ser Asn Leu Thr Trp Pro Asn Gly Leu Ala Ile Asp Tyr 
            900                 905                 910         


Gly Ser Gln Arg Leu Tyr Trp Ala Asp Ala Gly Met Lys Thr Ile Glu 
        915                 920                 925             


Phe Ala Gly Leu Asp Gly Ser Lys Arg Lys Val Leu Ile Gly Ser Gln 
    930                 935                 940                 


Leu Pro His Pro Phe Gly Leu Thr Leu Tyr Gly Glu Arg Ile Tyr Trp 
945                 950                 955                 960 


Thr Asp Trp Gln Thr Lys Ser Ile Gln Ser Ala Asp Arg Leu Thr Gly 
                965                 970                 975     


Leu Asp Arg Glu Thr Leu Gln Glu Asn Leu Glu Asn Leu Met Asp Ile 
            980                 985                 990         


His Val Phe His Arg Arg Arg Pro  Pro Val Ser Thr Pro  Cys Ala Met 
        995                 1000                 1005             


Glu Asn  Gly Gly Cys Ser His  Leu Cys Leu Arg Ser  Pro Asn Pro 
    1010                 1015                 1020             


Ser Gly  Phe Ser Cys Thr Cys  Pro Thr Gly Ile Asn  Leu Leu Ser 
    1025                 1030                 1035             


Asp Gly  Lys Thr Cys Ser Pro  Gly Met Asn Ser Phe  Leu Ile Phe 
    1040                 1045                 1050             


Ala Arg  Arg Ile Asp Ile Arg  Met Val Ser Leu Asp  Ile Pro Tyr 
    1055                 1060                 1065             


Phe Ala  Asp Val Val Val Pro  Ile Asn Ile Thr Met  Lys Asn Thr 
    1070                 1075                 1080             


Ile Ala  Ile Gly Val Asp Pro  Gln Glu Gly Lys Val  Tyr Trp Ser 
    1085                 1090                 1095             


Asp Ser  Thr Leu His Arg Ile  Ser Arg Ala Asn Leu  Asp Gly Ser 
    1100                 1105                 1110             


Gln His  Glu Asp Ile Ile Thr  Thr Gly Leu Gln Thr  Thr Asp Gly 
    1115                 1120                 1125             


Leu Ala  Val Asp Ala Ile Gly  Arg Lys Val Tyr Trp  Thr Asp Thr 
    1130                 1135                 1140             


Gly Thr  Asn Arg Ile Glu Val  Gly Asn Leu Asp Gly  Ser Met Arg 
    1145                 1150                 1155             


Lys Val  Leu Val Trp Gln Asn  Leu Asp Ser Pro Arg  Ala Ile Val 
    1160                 1165                 1170             


Leu Tyr  His Glu Met Gly Phe  Met Tyr Trp Thr Asp  Trp Gly Glu 
    1175                 1180                 1185             


Asn Ala  Lys Leu Glu Arg Ser  Gly Met Asp Gly Ser  Asp Arg Ala 
    1190                 1195                 1200             


Val Leu  Ile Asn Asn Asn Leu  Gly Trp Pro Asn Gly  Leu Thr Val 
    1205                 1210                 1215             


Asp Lys  Ala Ser Ser Gln Leu  Leu Trp Ala Asp Ala  His Thr Glu 
    1220                 1225                 1230             


Arg Ile  Glu Ala Ala Asp Leu  Asn Gly Ala Asn Arg  His Thr Leu 
    1235                 1240                 1245             


Val Ser  Pro Val Gln His Pro  Tyr Gly Leu Thr Leu  Leu Asp Ser 
    1250                 1255                 1260             


Tyr Ile  Tyr Trp Thr Asp Trp  Gln Thr Arg Ser Ile  His Arg Ala 
    1265                 1270                 1275             


Asp Lys  Gly Thr Gly Ser Asn  Val Ile Leu Val Arg  Ser Asn Leu 
    1280                 1285                 1290             


Pro Gly  Leu Met Asp Met Gln  Ala Val Asp Arg Ala  Gln Pro Leu 
    1295                 1300                 1305             


Gly Phe  Asn Lys Cys Gly Ser  Arg Asn Gly Gly Cys  Ser His Leu 
    1310                 1315                 1320             


Cys Leu  Pro Arg Pro Ser Gly  Phe Ser Cys Ala Cys  Pro Thr Gly 
    1325                 1330                 1335             


Ile Gln  Leu Lys Gly Asp Gly  Lys Thr Cys Asp Pro  Ser Pro Glu 
    1340                 1345                 1350             


Thr Tyr  Leu Leu Phe Ser Ser  Arg Gly Ser Ile Arg  Arg Ile Ser 
    1355                 1360                 1365             


Leu Asp  Thr Ser Asp His Thr  Asp Val His Val Pro  Val Pro Glu 
    1370                 1375                 1380             


Leu Asn  Asn Val Ile Ser Leu  Asp Tyr Asp Ser Val  Asp Gly Lys 
    1385                 1390                 1395             


Val Tyr  Tyr Thr Asp Val Phe  Leu Asp Val Ile Arg  Arg Ala Asp 
    1400                 1405                 1410             


Leu Asn  Gly Ser Asn Met Glu  Thr Val Ile Gly Arg  Gly Leu Lys 
    1415                 1420                 1425             


Thr Thr  Asp Gly Leu Ala Val  Asp Trp Val Ala Arg  Asn Leu Tyr 
    1430                 1435                 1440             


Trp Thr  Asp Thr Gly Arg Asn  Thr Ile Glu Ala Ser  Arg Leu Asp 
    1445                 1450                 1455             


Gly Ser  Cys Arg Lys Val Leu  Ile Asn Asn Ser Leu  Asp Glu Pro 
    1460                 1465                 1470             


Arg Ala  Ile Ala Val Phe Pro  Arg Lys Gly Tyr Leu  Phe Trp Thr 
    1475                 1480                 1485             


Asp Trp  Gly His Ile Ala Lys  Ile Glu Arg Ala Asn  Leu Asp Gly 
    1490                 1495                 1500             


Ser Glu  Arg Lys Val Leu Ile  Asn Thr Asp Leu Gly  Trp Pro Asn 
    1505                 1510                 1515             


Gly Leu  Thr Leu Asp Tyr Asp  Thr Arg Arg Ile Tyr  Trp Val Asp 
    1520                 1525                 1530             


Ala His  Leu Asp Arg Ile Glu  Ser Ala Asp Leu Asn  Gly Lys Leu 
    1535                 1540                 1545             


Arg Gln  Val Leu Val Ser His  Val Ser His Pro Phe  Ala Leu Thr 
    1550                 1555                 1560             


Gln Gln  Asp Arg Trp Ile Tyr  Trp Thr Asp Trp Gln  Thr Lys Ser 
    1565                 1570                 1575             


Ile Gln  Arg Val Asp Lys Tyr  Ser Gly Arg Asn Lys  Glu Thr Val 
    1580                 1585                 1590             


Leu Ala  Asn Val Glu Gly Leu  Met Asp Ile Ile Val  Val Ser Pro 
    1595                 1600                 1605             


Gln Arg  Gln Thr Gly Thr Asn  Ala Cys Gly Val Asn  Asn Gly Gly 
    1610                 1615                 1620             


Cys Thr  His Leu Cys Phe Ala  Arg Ala Ser Asp Phe  Val Cys Ala 
    1625                 1630                 1635             


Cys Pro  Asp Glu Pro Asp Ser  Arg Pro Cys Ser Leu  Val Pro Gly 
    1640                 1645                 1650             


Leu Val  Pro Pro Ala Pro Arg  Ala Thr Gly Met Ser  Glu Lys Ser 
    1655                 1660                 1665             


Pro Val  Leu Pro Asn Thr Pro  Pro Thr Thr Leu Tyr  Ser Ser Thr 
    1670                 1675                 1680             


Thr Arg  Thr Arg Thr Ser Leu  Glu Glu Val Glu Gly  Arg Cys Ser 
    1685                 1690                 1695             


Glu Arg  Asp Ala Arg Leu Gly  Leu Cys Ala Arg Ser  Asn Asp Ala 
    1700                 1705                 1710             


Val Pro  Ala Ala Pro Gly Glu  Gly Leu His Ile Ser  Tyr Ala Ile 
    1715                 1720                 1725             


Gly Gly  Leu Leu Ser Ile Leu  Leu Ile Leu Val Val  Ile Ala Ala 
    1730                 1735                 1740             


Leu Met  Leu Tyr Arg His Lys  Lys Ser Lys Phe Thr  Asp Pro Gly 
    1745                 1750                 1755             


Met Gly  Asn Leu Thr Tyr Ser  Asn Pro Ser Tyr Arg  Thr Ser Thr 
    1760                 1765                 1770             


Gln Glu  Val Lys Ile Glu Ala  Ile Pro Lys Pro Ala  Met Tyr Asn 
    1775                 1780                 1785             


Gln Leu  Cys Tyr Lys Lys Glu  Gly Gly Pro Asp His  Asn Tyr Thr 
    1790                 1795                 1800             


Lys Glu  Lys Ile Lys Ile Val  Glu Gly Ile Cys Leu  Leu Ser Gly 
    1805                 1810                 1815             


Asp Asp  Ala Glu Trp Asp Asp  Leu Lys Gln Leu Arg  Ser Ser Arg 
    1820                 1825                 1830             


Gly Gly  Leu Leu Arg Asp His  Val Cys Met Lys Thr  Asp Thr Val 
    1835                 1840                 1845             


Ser Ile  Gln Ala Ser Ser Gly  Ser Leu Asp Asp Thr  Glu Thr Glu 
    1850                 1855                 1860             


Gln Leu  Leu Gln Glu Glu Gln  Ser Glu Cys Ser Ser  Val His Thr 
    1865                 1870                 1875             


Ala Ala  Thr Pro Glu Arg Arg  Gly Ser Leu Pro Asp  Thr Gly Trp 
    1880                 1885                 1890             


Lys His  Glu Arg Lys Leu Ser  Ser Glu Ser Gln Val  
    1895                 1900                 1905 


<210>  22
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Ser Gly Arg Val Pro Gly Leu Cys Leu Leu Val Leu Leu Val 
1               5                   10                  15      


His Ala Arg Ala Ala Gln Tyr Ser Lys Ala Ala Gln Asp Val Asp Glu 
            20                  25                  30          


Cys Val Glu Gly Thr Asp Asn Cys His Ile Asp Ala Ile Cys Gln Asn 
        35                  40                  45              


Thr Pro Arg Ser Tyr Lys Cys Ile Cys Lys Ser Gly Tyr Thr Gly Asp 
    50                  55                  60                  


Gly Lys His Cys Lys Asp Val Asp Glu Cys Glu Arg Glu Asp Asn Ala 
65                  70                  75                  80  


Gly Cys Val His Asp Cys Val Asn Ile Pro Gly Asn Tyr Arg Cys Thr 
                85                  90                  95      


Cys Tyr Asp Gly Phe His Leu Ala His Asp Gly His Asn Cys Leu Asp 
            100                 105                 110         


Val Asp Glu Cys Ala Glu Gly Asn Gly Gly Cys Gln Gln Ser Cys Val 
        115                 120                 125             


Asn Met Met Gly Ser Tyr Glu Cys His Cys Arg Glu Gly Phe Phe Leu 
    130                 135                 140                 


Ser Asp Asn Gln His Thr Cys Ile Gln Arg Pro Glu Glu Gly Met Asn 
145                 150                 155                 160 


Cys Met Asn Lys Asn His Gly Cys Ala His Ile Cys Arg Glu Thr Pro 
                165                 170                 175     


Lys Gly Gly Ile Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Thr Lys 
            180                 185                 190         


Asn Gln Arg Asp Cys Lys Leu Thr Cys Asn Tyr Gly Asn Gly Gly Cys 
        195                 200                 205             


Gln His Thr Cys Asp Asp Thr Glu Gln Gly Pro Arg Cys Gly Cys His 
    210                 215                 220                 


Ile Lys Phe Val Leu His Thr Asp Gly Lys Thr Cys Ile Glu Thr Cys 
225                 230                 235                 240 


Ala Val Asn Asn Gly Gly Cys Asp Ser Lys Cys His Asp Ala Ala Thr 
                245                 250                 255     


Gly Val His Cys Thr Cys Pro Val Gly Phe Met Leu Gln Pro Asp Arg 
            260                 265                 270         


Lys Thr Cys Lys Asp Ile Asp Glu Cys Arg Leu Asn Asn Gly Gly Cys 
        275                 280                 285             


Asp His Ile Cys Arg Asn Thr Val Gly Ser Phe Glu Cys Ser Cys Lys 
    290                 295                 300                 


Lys Gly Tyr Lys Leu Leu Ile Asn Glu Arg Asn Cys Gln Asp Ile Asp 
305                 310                 315                 320 


Glu Cys Ser Phe Asp Arg Thr Cys Asp His Ile Cys Val Asn Thr Pro 
                325                 330                 335     


Gly Ser Phe Gln Cys Leu Cys His Arg Gly Tyr Leu Leu Tyr Gly Ile 
            340                 345                 350         


Thr His Cys Gly Asp Val Asp Glu Cys Ser Ile Asn Arg Gly Gly Cys 
        355                 360                 365             


Arg Phe Gly Cys Ile Asn Thr Pro Gly Ser Tyr Gln Cys Thr Cys Pro 
    370                 375                 380                 


Ala Gly Gln Gly Arg Leu His Trp Asn Gly Lys Asp Cys Thr Glu Pro 
385                 390                 395                 400 


Leu Lys Cys Gln Gly Ser Pro Gly Ala Ser Lys Ala Met Leu Ser Cys 
                405                 410                 415     


Asn Arg Ser Gly Lys Lys Asp Thr Cys Ala Leu Thr Cys Pro Ser Arg 
            420                 425                 430         


Ala Arg Phe Leu Pro Glu Ser Glu Asn Gly Phe Thr Val Ser Cys Gly 
        435                 440                 445             


Thr Pro Ser Pro Arg Ala Ala Pro Ala Arg Ala Gly His Asn Gly Asn 
    450                 455                 460                 


Ser Thr Asn Ser Asn His Cys His Glu Ala Ala Val Leu Ser Ile Lys 
465                 470                 475                 480 


Gln Arg Ala Ser Phe Lys Ile Lys Asp Ala Lys Cys Arg Leu His Leu 
                485                 490                 495     


Arg Asn Lys Gly Lys Thr Glu Glu Ala Gly Arg Ile Thr Gly Pro Gly 
            500                 505                 510         


Gly Ala Pro Cys Ser Glu Cys Gln Val Thr Phe Ile His Leu Lys Cys 
        515                 520                 525             


Asp Ser Ser Arg Lys Gly Lys Gly Arg Arg Ala Arg Thr Pro Pro Gly 
    530                 535                 540                 


Lys Glu Val Thr Arg Leu Thr Leu Glu Leu Glu Ala Glu Val Arg Ala 
545                 550                 555                 560 


Glu Glu Thr Thr Ala Ser Cys Gly Leu Pro Cys Leu Arg Gln Arg Met 
                565                 570                 575     


Glu Arg Arg Leu Lys Gly Ser Leu Lys Met Leu Arg Lys Ser Ile Asn 
            580                 585                 590         


Gln Asp Arg Phe Leu Leu Arg Leu Ala Gly Leu Asp Tyr Glu Leu Ala 
        595                 600                 605             


His Lys Pro Gly Leu Val Ala Gly Glu Arg Ala Glu Pro Met Glu Ser 
    610                 615                 620                 


Cys Arg Pro Gly Gln His Arg Ala Gly Thr Lys Cys Val Ser Cys Pro 
625                 630                 635                 640 


Gln Gly Thr Tyr Tyr His Gly Gln Thr Glu Gln Cys Val Pro Cys Pro 
                645                 650                 655     


Ala Gly Thr Phe Gln Glu Arg Glu Gly Gln Leu Ser Cys Asp Leu Cys 
            660                 665                 670         


Pro Gly Ser Asp Ala His Gly Pro Leu Gly Ala Thr Asn Val Thr Thr 
        675                 680                 685             


Cys Ala Gly Gln Cys Pro Pro Gly Gln His Ser Val Asp Gly Phe Lys 
    690                 695                 700                 


Pro Cys Gln Pro Cys Pro Arg Gly Thr Tyr Gln Pro Glu Ala Gly Arg 
705                 710                 715                 720 


Thr Leu Cys Phe Pro Cys Gly Gly Gly Leu Thr Thr Lys His Glu Gly 
                725                 730                 735     


Ala Ile Ser Phe Gln Asp Cys Asp Thr Lys Val Gln Cys Ser Pro Gly 
            740                 745                 750         


His Tyr Tyr Asn Thr Ser Ile His Arg Cys Ile Arg Cys Ala Met Gly 
        755                 760                 765             


Ser Tyr Gln Pro Asp Phe Arg Gln Asn Phe Cys Ser Arg Cys Pro Gly 
    770                 775                 780                 


Asn Thr Ser Thr Asp Phe Asp Gly Ser Thr Ser Val Ala Gln Cys Lys 
785                 790                 795                 800 


Asn Arg Gln Cys Gly Gly Glu Leu Gly Glu Phe Thr Gly Tyr Ile Glu 
                805                 810                 815     


Ser Pro Asn Tyr Pro Gly Asn Tyr Pro Ala Gly Val Glu Cys Ile Trp 
            820                 825                 830         


Asn Ile Asn Pro Pro Pro Lys Arg Lys Ile Leu Ile Val Val Pro Glu 
        835                 840                 845             


Ile Phe Leu Pro Ser Glu Asp Glu Cys Gly Asp Val Leu Val Met Arg 
    850                 855                 860                 


Lys Asn Ser Ser Pro Ser Ser Ile Thr Thr Tyr Glu Thr Cys Gln Thr 
865                 870                 875                 880 


Tyr Glu Arg Pro Ile Ala Phe Thr Ala Arg Ser Arg Lys Leu Trp Ile 
                885                 890                 895     


Asn Phe Lys Thr Ser Glu Ala Asn Ser Ala Arg Gly Phe Gln Ile Pro 
            900                 905                 910         


Tyr Val Thr Tyr Asp Glu Asp Tyr Glu Gln Leu Val Glu Asp Ile Val 
        915                 920                 925             


Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His Gln Glu Ile Leu Lys 
    930                 935                 940                 


Asp Lys Lys Leu Ile Lys Ala Phe Phe Glu Val Leu Ala His Pro Gln 
945                 950                 955                 960 


Asn Tyr Phe Lys Tyr Thr Glu Lys His Lys Glu Met Leu Pro Lys Ser 
                965                 970                 975     


Phe Ile Lys Leu Leu Arg Ser Lys Val Ser Ser Phe Leu Arg Pro Tyr 
            980                 985                 990         


Lys 
    


<210>  23
<211>  1615
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Ala Ala Pro Pro Gly Pro Pro Trp Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Cys Gly Cys Pro Ala Pro Ala Ala Ala Ser 
            20                  25                  30          


Pro Leu Leu Leu Phe Ala Asn Arg Arg Asp Val Arg Leu Val Asp Ala 
        35                  40                  45              


Gly Gly Val Lys Leu Glu Ser Thr Ile Val Val Ser Gly Leu Glu Asp 
    50                  55                  60                  


Ala Ala Ala Val Asp Phe Gln Phe Ser Lys Gly Ala Val Tyr Trp Thr 
65                  70                  75                  80  


Asp Val Ser Glu Glu Ala Ile Lys Gln Thr Tyr Leu Asn Gln Thr Gly 
                85                  90                  95      


Ala Ala Val Gln Asn Val Val Ile Ser Gly Leu Val Ser Pro Asp Gly 
            100                 105                 110         


Leu Ala Cys Asp Trp Val Gly Lys Lys Leu Tyr Trp Thr Asp Ser Glu 
        115                 120                 125             


Thr Asn Arg Ile Glu Val Ala Asn Leu Asn Gly Thr Ser Arg Lys Val 
    130                 135                 140                 


Leu Phe Trp Gln Asp Leu Asp Gln Pro Arg Ala Ile Ala Leu Asp Pro 
145                 150                 155                 160 


Ala His Gly Tyr Met Tyr Trp Thr Asp Trp Gly Glu Thr Pro Arg Ile 
                165                 170                 175     


Glu Arg Ala Gly Met Asp Gly Ser Thr Arg Lys Ile Ile Val Asp Ser 
            180                 185                 190         


Asp Ile Tyr Trp Pro Asn Gly Leu Thr Ile Asp Leu Glu Glu Gln Lys 
        195                 200                 205             


Leu Tyr Trp Ala Asp Ala Lys Leu Ser Phe Ile His Arg Ala Asn Leu 
    210                 215                 220                 


Asp Gly Ser Phe Arg Gln Lys Val Val Glu Gly Ser Leu Thr His Pro 
225                 230                 235                 240 


Phe Ala Leu Thr Leu Ser Gly Asp Thr Leu Tyr Trp Thr Asp Trp Gln 
                245                 250                 255     


Thr Arg Ser Ile His Ala Cys Asn Lys Arg Thr Gly Gly Lys Arg Lys 
            260                 265                 270         


Glu Ile Leu Ser Ala Leu Tyr Ser Pro Met Asp Ile Gln Val Leu Ser 
        275                 280                 285             


Gln Glu Arg Gln Pro Phe Phe His Thr Arg Cys Glu Glu Asp Asn Gly 
    290                 295                 300                 


Gly Cys Ser His Leu Cys Leu Leu Ser Pro Ser Glu Pro Phe Tyr Thr 
305                 310                 315                 320 


Cys Ala Cys Pro Thr Gly Val Gln Leu Gln Asp Asn Gly Arg Thr Cys 
                325                 330                 335     


Lys Ala Gly Ala Glu Glu Val Leu Leu Leu Ala Arg Arg Thr Asp Leu 
            340                 345                 350         


Arg Arg Ile Ser Leu Asp Thr Pro Asp Phe Thr Asp Ile Val Leu Gln 
        355                 360                 365             


Val Asp Asp Ile Arg His Ala Ile Ala Ile Asp Tyr Asp Pro Leu Glu 
    370                 375                 380                 


Gly Tyr Val Tyr Trp Thr Asp Asp Glu Val Arg Ala Ile Arg Arg Ala 
385                 390                 395                 400 


Tyr Leu Asp Gly Ser Gly Ala Gln Thr Leu Val Asn Thr Glu Ile Asn 
                405                 410                 415     


Asp Pro Asp Gly Ile Ala Val Asp Trp Val Ala Arg Asn Leu Tyr Trp 
            420                 425                 430         


Thr Asp Thr Gly Thr Asp Arg Ile Glu Val Thr Arg Leu Asn Gly Thr 
        435                 440                 445             


Ser Arg Lys Ile Leu Val Ser Glu Asp Leu Asp Glu Pro Arg Ala Ile 
    450                 455                 460                 


Ala Leu His Pro Val Met Gly Leu Met Tyr Trp Thr Asp Trp Gly Glu 
465                 470                 475                 480 


Asn Pro Lys Ile Glu Cys Ala Asn Leu Asp Gly Gln Glu Arg Arg Val 
                485                 490                 495     


Leu Val Asn Ala Ser Leu Gly Trp Pro Asn Gly Leu Ala Leu Asp Leu 
            500                 505                 510         


Gln Glu Gly Lys Leu Tyr Trp Gly Asp Ala Lys Thr Asp Lys Ile Glu 
        515                 520                 525             


Val Ile Asn Val Asp Gly Thr Lys Arg Arg Thr Leu Leu Glu Asp Lys 
    530                 535                 540                 


Leu Pro His Ile Phe Gly Phe Thr Leu Leu Gly Asp Phe Ile Tyr Trp 
545                 550                 555                 560 


Thr Asp Trp Gln Arg Arg Ser Ile Glu Arg Val His Lys Val Lys Ala 
                565                 570                 575     


Ser Arg Asp Val Ile Ile Asp Gln Leu Pro Asp Leu Met Gly Leu Lys 
            580                 585                 590         


Ala Val Asn Val Ala Lys Val Val Gly Thr Asn Pro Cys Ala Asp Arg 
        595                 600                 605             


Asn Gly Gly Cys Ser His Leu Cys Phe Phe Thr Pro His Ala Thr Arg 
    610                 615                 620                 


Cys Gly Cys Pro Ile Gly Leu Glu Leu Leu Ser Asp Met Lys Thr Cys 
625                 630                 635                 640 


Ile Val Pro Glu Ala Phe Leu Val Phe Thr Ser Arg Ala Ala Ile His 
                645                 650                 655     


Arg Ile Ser Leu Glu Thr Asn Asn Asn Asp Val Ala Ile Pro Leu Thr 
            660                 665                 670         


Gly Val Lys Glu Ala Ser Ala Leu Asp Phe Asp Val Ser Asn Asn His 
        675                 680                 685             


Ile Tyr Trp Thr Asp Val Ser Leu Lys Thr Ile Ser Arg Ala Phe Met 
    690                 695                 700                 


Asn Gly Ser Ser Val Glu His Val Val Glu Phe Gly Leu Asp Tyr Pro 
705                 710                 715                 720 


Glu Gly Met Ala Val Asp Trp Met Gly Lys Asn Leu Tyr Trp Ala Asp 
                725                 730                 735     


Thr Gly Thr Asn Arg Ile Glu Val Ala Arg Leu Asp Gly Gln Phe Arg 
            740                 745                 750         


Gln Val Leu Val Trp Arg Asp Leu Asp Asn Pro Arg Ser Leu Ala Leu 
        755                 760                 765             


Asp Pro Thr Lys Gly Tyr Ile Tyr Trp Thr Glu Trp Gly Gly Lys Pro 
    770                 775                 780                 


Arg Ile Val Arg Ala Phe Met Asp Gly Thr Asn Cys Met Thr Leu Val 
785                 790                 795                 800 


Asp Lys Val Gly Arg Ala Asn Asp Leu Thr Ile Asp Tyr Ala Asp Gln 
                805                 810                 815     


Arg Leu Tyr Trp Thr Asp Leu Asp Thr Asn Met Ile Glu Ser Ser Asn 
            820                 825                 830         


Met Leu Gly Gln Glu Arg Val Val Ile Ala Asp Asp Leu Pro His Pro 
        835                 840                 845             


Phe Gly Leu Thr Gln Tyr Ser Asp Tyr Ile Tyr Trp Thr Asp Trp Asn 
    850                 855                 860                 


Leu His Ser Ile Glu Arg Ala Asp Lys Thr Ser Gly Arg Asn Arg Thr 
865                 870                 875                 880 


Leu Ile Gln Gly His Leu Asp Phe Val Met Asp Ile Leu Val Phe His 
                885                 890                 895     


Ser Ser Arg Gln Asp Gly Leu Asn Asp Cys Met His Asn Asn Gly Gln 
            900                 905                 910         


Cys Gly Gln Leu Cys Leu Ala Ile Pro Gly Gly His Arg Cys Gly Cys 
        915                 920                 925             


Ala Ser His Tyr Thr Leu Asp Pro Ser Ser Arg Asn Cys Ser Pro Pro 
    930                 935                 940                 


Thr Thr Phe Leu Leu Phe Ser Gln Lys Ser Ala Ile Ser Arg Met Ile 
945                 950                 955                 960 


Pro Asp Asp Gln His Ser Pro Asp Leu Ile Leu Pro Leu His Gly Leu 
                965                 970                 975     


Arg Asn Val Lys Ala Ile Asp Tyr Asp Pro Leu Asp Lys Phe Ile Tyr 
            980                 985                 990         


Trp Val Asp Gly Arg Gln Asn Ile  Lys Arg Ala Lys Asp  Asp Gly Thr 
        995                 1000                 1005             


Gln Pro  Phe Val Leu Thr Ser  Leu Ser Gln Gly Gln  Asn Pro Asp 
    1010                 1015                 1020             


Arg Gln  Pro His Asp Leu Ser  Ile Asp Ile Tyr Ser  Arg Thr Leu 
    1025                 1030                 1035             


Phe Trp  Thr Cys Glu Ala Thr  Asn Thr Ile Asn Val  His Arg Leu 
    1040                 1045                 1050             


Ser Gly  Glu Ala Met Gly Val  Val Leu Arg Gly Asp  Arg Asp Lys 
    1055                 1060                 1065             


Pro Arg  Ala Ile Val Val Asn  Ala Glu Arg Gly Tyr  Leu Tyr Phe 
    1070                 1075                 1080             


Thr Asn  Met Gln Asp Arg Ala  Ala Lys Ile Glu Arg  Ala Ala Leu 
    1085                 1090                 1095             


Asp Gly  Thr Glu Arg Glu Val  Leu Phe Thr Thr Gly  Leu Ile Arg 
    1100                 1105                 1110             


Pro Val  Ala Leu Val Val Asp  Asn Thr Leu Gly Lys  Leu Phe Trp 
    1115                 1120                 1125             


Val Asp  Ala Asp Leu Lys Arg  Ile Glu Ser Cys Asp  Leu Ser Gly 
    1130                 1135                 1140             


Ala Asn  Arg Leu Thr Leu Glu  Asp Ala Asn Ile Val  Gln Pro Leu 
    1145                 1150                 1155             


Gly Leu  Thr Ile Leu Gly Lys  His Leu Tyr Trp Ile  Asp Arg Gln 
    1160                 1165                 1170             


Gln Gln  Met Ile Glu Arg Val  Glu Lys Thr Thr Gly  Asp Lys Arg 
    1175                 1180                 1185             


Thr Arg  Ile Gln Gly Arg Val  Ala His Leu Thr Gly  Ile His Ala 
    1190                 1195                 1200             


Val Glu  Glu Val Ser Leu Glu  Glu Phe Ser Ala His  Pro Cys Ala 
    1205                 1210                 1215             


Arg Asp  Asn Gly Gly Cys Ser  His Ile Cys Ile Ala  Lys Gly Asp 
    1220                 1225                 1230             


Gly Thr  Pro Arg Cys Ser Cys  Pro Val His Leu Val  Leu Leu Gln 
    1235                 1240                 1245             


Asn Leu  Leu Thr Cys Gly Glu  Pro Pro Thr Cys Ser  Pro Asp Gln 
    1250                 1255                 1260             


Phe Ala  Cys Ala Thr Gly Glu  Ile Asp Cys Ile Pro  Gly Ala Trp 
    1265                 1270                 1275             


Arg Cys  Asp Gly Phe Pro Glu  Cys Asp Asp Gln Ser  Asp Glu Glu 
    1280                 1285                 1290             


Gly Cys  Pro Val Cys Ser Ala  Ala Gln Phe Pro Cys  Ala Arg Gly 
    1295                 1300                 1305             


Gln Cys  Val Asp Leu Arg Leu  Arg Cys Asp Gly Glu  Ala Asp Cys 
    1310                 1315                 1320             


Gln Asp  Arg Ser Asp Glu Ala  Asp Cys Asp Ala Ile  Cys Leu Pro 
    1325                 1330                 1335             


Asn Gln  Phe Arg Cys Ala Ser  Gly Gln Cys Val Leu  Ile Lys Gln 
    1340                 1345                 1350             


Gln Cys  Asp Ser Phe Pro Asp  Cys Ile Asp Gly Ser  Asp Glu Leu 
    1355                 1360                 1365             


Met Cys  Glu Ile Thr Lys Pro  Pro Ser Asp Asp Ser  Pro Ala His 
    1370                 1375                 1380             


Ser Ser  Ala Ile Gly Pro Val  Ile Gly Ile Ile Leu  Ser Leu Phe 
    1385                 1390                 1395             


Val Met  Gly Gly Val Tyr Phe  Val Cys Gln Arg Val  Val Cys Gln 
    1400                 1405                 1410             


Arg Tyr  Ala Gly Ala Asn Gly  Pro Phe Pro His Glu  Tyr Val Ser 
    1415                 1420                 1425             


Gly Thr  Pro His Val Pro Leu  Asn Phe Ile Ala Pro  Gly Gly Ser 
    1430                 1435                 1440             


Gln His  Gly Pro Phe Thr Gly  Ile Ala Cys Gly Lys  Ser Met Met 
    1445                 1450                 1455             


Ser Ser  Val Ser Leu Met Gly  Gly Arg Gly Gly Val  Pro Leu Tyr 
    1460                 1465                 1470             


Asp Arg  Asn His Val Thr Gly  Ala Ser Ser Ser Ser  Ser Ser Ser 
    1475                 1480                 1485             


Thr Lys  Ala Thr Leu Tyr Pro  Pro Ile Leu Asn Pro  Pro Pro Ser 
    1490                 1495                 1500             


Pro Ala  Thr Asp Pro Ser Leu  Tyr Asn Met Asp Met  Phe Tyr Ser 
    1505                 1510                 1515             


Ser Asn  Ile Pro Ala Thr Ala  Arg Pro Tyr Arg Pro  Tyr Ile Ile 
    1520                 1525                 1530             


Arg Gly  Met Ala Pro Pro Thr  Thr Pro Cys Ser Thr  Asp Val Cys 
    1535                 1540                 1545             


Asp Ser  Asp Tyr Ser Ala Ser  Arg Trp Lys Ala Ser  Lys Tyr Tyr 
    1550                 1555                 1560             


Leu Asp  Leu Asn Ser Asp Ser  Asp Pro Tyr Pro Pro  Pro Pro Thr 
    1565                 1570                 1575             


Pro His  Ser Gln Tyr Leu Ser  Ala Glu Asp Ser Cys  Pro Pro Ser 
    1580                 1585                 1590             


Pro Ala  Thr Glu Arg Ser Tyr  Phe His Leu Phe Pro  Pro Pro Pro 
    1595                 1600                 1605             


Ser Pro  Cys Thr Asp Ser Ser  
    1610                 1615 


<210>  24
<211>  1541
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Phe Leu Glu Glu Ala Arg Ala Ala Gly Arg Ala Val Val Leu 
1               5                   10                  15      


Ala Leu Val Leu Leu Leu Leu Pro Ala Val Pro Val Gly Ala Ser Val 
            20                  25                  30          


Pro Pro Arg Pro Leu Leu Pro Leu Gln Pro Gly Met Pro His Val Cys 
        35                  40                  45              


Ala Glu Gln Glu Leu Thr Leu Val Gly Arg Arg Gln Pro Cys Val Gln 
    50                  55                  60                  


Ala Leu Ser His Thr Val Pro Val Trp Lys Ala Gly Cys Gly Trp Gln 
65                  70                  75                  80  


Ala Trp Cys Val Gly His Glu Arg Arg Thr Val Tyr Tyr Met Gly Tyr 
                85                  90                  95      


Arg Gln Val Tyr Thr Thr Glu Ala Arg Thr Val Leu Arg Cys Cys Arg 
            100                 105                 110         


Gly Trp Met Gln Gln Pro Asp Glu Glu Gly Cys Leu Ser Ala Glu Cys 
        115                 120                 125             


Ser Ala Ser Leu Cys Phe His Gly Gly Arg Cys Val Pro Gly Ser Ala 
    130                 135                 140                 


Gln Pro Cys His Cys Pro Pro Gly Phe Gln Gly Pro Arg Cys Gln Tyr 
145                 150                 155                 160 


Asp Val Asp Glu Cys Arg Thr His Asn Gly Gly Cys Gln His Arg Cys 
                165                 170                 175     


Val Asn Thr Pro Gly Ser Tyr Leu Cys Glu Cys Lys Pro Gly Phe Arg 
            180                 185                 190         


Leu His Thr Asp Ser Arg Thr Cys Leu Ala Ile Asn Ser Cys Ala Leu 
        195                 200                 205             


Gly Asn Gly Gly Cys Gln His His Cys Val Gln Leu Thr Ile Thr Arg 
    210                 215                 220                 


His Arg Cys Gln Cys Arg Pro Gly Phe Gln Leu Gln Glu Asp Gly Arg 
225                 230                 235                 240 


His Cys Val Arg Arg Ser Pro Cys Ala Asn Arg Asn Gly Ser Cys Met 
                245                 250                 255     


His Arg Cys Gln Val Val Arg Gly Leu Ala Arg Cys Glu Cys His Val 
            260                 265                 270         


Gly Tyr Gln Leu Ala Ala Asp Gly Lys Ala Cys Glu Asp Val Asp Glu 
        275                 280                 285             


Cys Ala Ala Gly Leu Ala Gln Cys Ala His Gly Cys Leu Asn Thr Gln 
    290                 295                 300                 


Gly Ser Phe Lys Cys Val Cys His Ala Gly Tyr Glu Leu Gly Ala Asp 
305                 310                 315                 320 


Gly Arg Gln Cys Tyr Arg Ile Glu Met Glu Ile Val Asn Ser Cys Glu 
                325                 330                 335     


Ala Asn Asn Gly Gly Cys Ser His Gly Cys Ser His Thr Ser Ala Gly 
            340                 345                 350         


Pro Leu Cys Thr Cys Pro Arg Gly Tyr Glu Leu Asp Thr Asp Gln Arg 
        355                 360                 365             


Thr Cys Ile Asp Val Asp Asp Cys Ala Asp Ser Pro Cys Cys Gln Gln 
    370                 375                 380                 


Val Cys Thr Asn Asn Pro Gly Gly Tyr Glu Cys Gly Cys Tyr Ala Gly 
385                 390                 395                 400 


Tyr Arg Leu Ser Ala Asp Gly Cys Gly Cys Glu Asp Val Asp Glu Cys 
                405                 410                 415     


Ala Ser Ser Arg Gly Gly Cys Glu His His Cys Thr Asn Leu Ala Gly 
            420                 425                 430         


Ser Phe Gln Cys Ser Cys Glu Ala Gly Tyr Arg Leu His Glu Asp Arg 
        435                 440                 445             


Arg Gly Cys Ser Pro Leu Glu Glu Pro Met Val Asp Leu Asp Gly Glu 
    450                 455                 460                 


Leu Pro Phe Val Arg Pro Leu Pro His Ile Ala Val Leu Gln Asp Glu 
465                 470                 475                 480 


Leu Pro Gln Leu Phe Gln Asp Asp Asp Val Gly Ala Asp Glu Glu Glu 
                485                 490                 495     


Ala Glu Leu Arg Gly Glu His Thr Leu Thr Glu Lys Phe Val Cys Leu 
            500                 505                 510         


Asp Asp Ser Phe Gly His Asp Cys Ser Leu Thr Cys Asp Asp Cys Arg 
        515                 520                 525             


Asn Gly Gly Thr Cys Leu Leu Gly Leu Asp Gly Cys Asp Cys Pro Glu 
    530                 535                 540                 


Gly Trp Thr Gly Leu Ile Cys Asn Glu Thr Cys Pro Pro Asp Thr Phe 
545                 550                 555                 560 


Gly Lys Asn Cys Ser Phe Ser Cys Ser Cys Gln Asn Gly Gly Thr Cys 
                565                 570                 575     


Asp Ser Val Thr Gly Ala Cys Arg Cys Pro Pro Gly Val Ser Gly Thr 
            580                 585                 590         


Asn Cys Glu Asp Gly Cys Pro Lys Gly Tyr Tyr Gly Lys His Cys Arg 
        595                 600                 605             


Lys Lys Cys Asn Cys Ala Asn Arg Gly Arg Cys His Arg Leu Tyr Gly 
    610                 615                 620                 


Ala Cys Leu Cys Asp Pro Gly Leu Tyr Gly Arg Phe Cys His Leu Thr 
625                 630                 635                 640 


Cys Pro Pro Trp Ala Phe Gly Pro Gly Cys Ser Glu Glu Cys Gln Cys 
                645                 650                 655     


Val Gln Pro His Thr Gln Ser Cys Asp Lys Arg Asp Gly Ser Cys Ser 
            660                 665                 670         


Cys Lys Ala Gly Phe Arg Gly Glu Arg Cys Gln Ala Glu Cys Glu Leu 
        675                 680                 685             


Gly Tyr Phe Gly Pro Gly Cys Trp Gln Ala Cys Thr Cys Pro Val Gly 
    690                 695                 700                 


Val Ala Cys Asp Ser Val Ser Gly Glu Cys Gly Lys Arg Cys Pro Ala 
705                 710                 715                 720 


Gly Phe Gln Gly Glu Asp Cys Gly Gln Glu Cys Pro Val Gly Thr Phe 
                725                 730                 735     


Gly Val Asn Cys Ser Ser Ser Cys Ser Cys Gly Gly Ala Pro Cys His 
            740                 745                 750         


Gly Val Thr Gly Gln Cys Arg Cys Pro Pro Gly Arg Thr Gly Glu Asp 
        755                 760                 765             


Cys Glu Ala Asp Cys Pro Glu Gly Arg Trp Gly Leu Gly Cys Gln Glu 
    770                 775                 780                 


Ile Cys Pro Ala Cys Gln His Ala Ala Arg Cys Asp Pro Glu Thr Gly 
785                 790                 795                 800 


Ala Cys Leu Cys Leu Pro Gly Phe Val Gly Ser Arg Cys Gln Asp Val 
                805                 810                 815     


Cys Pro Ala Gly Trp Tyr Gly Pro Ser Cys Gln Thr Arg Cys Ser Cys 
            820                 825                 830         


Ala Asn Asp Gly His Cys His Pro Ala Thr Gly His Cys Ser Cys Ala 
        835                 840                 845             


Pro Gly Trp Thr Gly Phe Ser Cys Gln Arg Ala Cys Asp Thr Gly His 
    850                 855                 860                 


Trp Gly Pro Asp Cys Ser His Pro Cys Asn Cys Ser Ala Gly His Gly 
865                 870                 875                 880 


Ser Cys Asp Ala Ile Ser Gly Leu Cys Leu Cys Glu Ala Gly Tyr Val 
                885                 890                 895     


Gly Pro Arg Cys Glu Gln Gln Cys Pro Gln Gly His Phe Gly Pro Gly 
            900                 905                 910         


Cys Glu Gln Arg Cys Gln Cys Gln His Gly Ala Ala Cys Asp His Val 
        915                 920                 925             


Ser Gly Ala Cys Thr Cys Pro Ala Gly Trp Arg Gly Thr Phe Cys Glu 
    930                 935                 940                 


His Ala Cys Pro Ala Gly Phe Phe Gly Leu Asp Cys Arg Ser Ala Cys 
945                 950                 955                 960 


Asn Cys Thr Ala Gly Ala Ala Cys Asp Ala Val Asn Gly Ser Cys Leu 
                965                 970                 975     


Cys Pro Ala Gly Arg Arg Gly Pro Arg Cys Ala Glu Thr Cys Pro Ala 
            980                 985                 990         


His Thr Tyr Gly His Asn Cys Ser  Gln Ala Cys Ala Cys  Phe Asn Gly 
        995                 1000                 1005             


Ala Ser  Cys Asp Pro Val His  Gly Gln Cys His Cys  Ala Pro Gly 
    1010                 1015                 1020             


Trp Met  Gly Pro Ser Cys Leu  Gln Ala Cys Pro Ala  Gly Leu Tyr 
    1025                 1030                 1035             


Gly Asp  Asn Cys Arg His Ser  Cys Leu Cys Gln Asn  Gly Gly Thr 
    1040                 1045                 1050             


Cys Asp  Pro Val Ser Gly His  Cys Ala Cys Pro Glu  Gly Trp Ala 
    1055                 1060                 1065             


Gly Leu  Ala Cys Glu Lys Glu  Cys Leu Pro Arg Asp  Val Arg Ala 
    1070                 1075                 1080             


Gly Cys  Arg His Ser Gly Gly  Cys Leu Asn Gly Gly  Leu Cys Asp 
    1085                 1090                 1095             


Pro His  Thr Gly Arg Cys Leu  Cys Pro Ala Gly Trp  Thr Gly Asp 
    1100                 1105                 1110             


Lys Cys  Gln Ser Pro Cys Leu  Arg Gly Trp Phe Gly  Glu Ala Cys 
    1115                 1120                 1125             


Ala Gln  Arg Cys Ser Cys Pro  Pro Gly Ala Ala Cys  His His Val 
    1130                 1135                 1140             


Thr Gly  Ala Cys Arg Cys Pro  Pro Gly Phe Thr Gly  Ser Gly Cys 
    1145                 1150                 1155             


Glu Gln  Ala Cys Pro Pro Gly  Ser Phe Gly Glu Asp  Cys Ala Gln 
    1160                 1165                 1170             


Met Cys  Gln Cys Pro Gly Glu  Asn Pro Ala Cys His  Pro Ala Thr 
    1175                 1180                 1185             


Gly Thr  Cys Ser Cys Ala Ala  Gly Tyr His Gly Pro  Ser Cys Gln 
    1190                 1195                 1200             


Gln Arg  Cys Pro Pro Gly Arg  Tyr Gly Pro Gly Cys  Glu Gln Leu 
    1205                 1210                 1215             


Cys Gly  Cys Leu Asn Gly Gly  Ser Cys Asp Ala Ala  Thr Gly Ala 
    1220                 1225                 1230             


Cys Arg  Cys Pro Thr Gly Phe  Leu Gly Thr Asp Cys  Asn Leu Thr 
    1235                 1240                 1245             


Cys Pro  Gln Gly Arg Phe Gly  Pro Asn Cys Thr His  Val Cys Gly 
    1250                 1255                 1260             


Cys Gly  Gln Gly Ala Ala Cys  Asp Pro Val Thr Gly  Thr Cys Leu 
    1265                 1270                 1275             


Cys Pro  Pro Gly Arg Ala Gly  Val Arg Cys Glu Arg  Gly Cys Pro 
    1280                 1285                 1290             


Gln Asn  Arg Phe Gly Val Gly  Cys Glu His Thr Cys  Ser Cys Arg 
    1295                 1300                 1305             


Asn Gly  Gly Leu Cys His Ala  Ser Asn Gly Ser Cys  Ser Cys Gly 
    1310                 1315                 1320             


Leu Gly  Trp Thr Gly Arg His  Cys Glu Leu Ala Cys  Pro Pro Gly 
    1325                 1330                 1335             


Arg Tyr  Gly Ala Ala Cys His  Leu Glu Cys Ser Cys  His Asn Asn 
    1340                 1345                 1350             


Ser Thr  Cys Glu Pro Ala Thr  Gly Thr Cys Arg Cys  Gly Pro Gly 
    1355                 1360                 1365             


Phe Tyr  Gly Gln Ala Cys Glu  His Pro Cys Pro Pro  Gly Phe His 
    1370                 1375                 1380             


Gly Ala  Gly Cys Gln Gly Leu  Cys Trp Cys Gln His  Gly Ala Pro 
    1385                 1390                 1395             


Cys Asp  Pro Ile Ser Gly Arg  Cys Leu Cys Pro Ala  Gly Phe His 
    1400                 1405                 1410             


Gly His  Phe Cys Glu Arg Gly  Cys Glu Pro Gly Ser  Phe Gly Glu 
    1415                 1420                 1425             


Gly Cys  His Gln Arg Cys Asp  Cys Asp Gly Gly Ala  Pro Cys Asp 
    1430                 1435                 1440             


Pro Val  Thr Gly Leu Cys Leu  Cys Pro Pro Gly Arg  Ser Gly Ala 
    1445                 1450                 1455             


Thr Cys  Asn Leu Asp Cys Arg  Arg Gly Gln Phe Gly  Pro Ser Cys 
    1460                 1465                 1470             


Thr Leu  His Cys Asp Cys Gly  Gly Gly Ala Asp Cys  Asp Pro Val 
    1475                 1480                 1485             


Ser Gly  Gln Cys His Cys Val  Asp Gly Tyr Met Gly  Pro Thr Cys 
    1490                 1495                 1500             


Arg Glu  Gly Gly Pro Leu Arg  Leu Pro Glu Asn Pro  Ser Leu Ala 
    1505                 1510                 1515             


Gln Gly  Ser Ala Gly Thr Leu  Pro Ala Ser Ser Arg  Pro Thr Ser 
    1520                 1525                 1530             


Arg Ser  Gly Gly Pro Ala Arg  His 
    1535                 1540     


<210>  25
<211>  1613
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Ala Val Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys Val Leu 
1               5                   10                  15      


Leu Arg Ala Ala Pro Leu Leu Leu Tyr Ala Asn Arg Arg Asp Leu Arg 
            20                  25                  30          


Leu Val Asp Ala Thr Asn Gly Lys Glu Asn Ala Thr Ile Val Val Gly 
        35                  40                  45              


Gly Leu Glu Asp Ala Ala Ala Val Asp Phe Val Phe Ser His Gly Leu 
    50                  55                  60                  


Ile Tyr Trp Ser Asp Val Ser Glu Glu Ala Ile Lys Arg Thr Glu Phe 
65                  70                  75                  80  


Asn Lys Thr Glu Ser Val Gln Asn Val Val Val Ser Gly Leu Leu Ser 
                85                  90                  95      


Pro Asp Gly Leu Ala Cys Asp Trp Leu Gly Glu Lys Leu Tyr Trp Thr 
            100                 105                 110         


Asp Ser Glu Thr Asn Arg Ile Glu Val Ser Asn Leu Asp Gly Ser Leu 
        115                 120                 125             


Arg Lys Val Leu Phe Trp Gln Glu Leu Asp Gln Pro Arg Ala Ile Ala 
    130                 135                 140                 


Leu Asp Pro Ser Ser Gly Phe Met Tyr Trp Thr Asp Trp Gly Glu Val 
145                 150                 155                 160 


Pro Lys Ile Glu Arg Ala Gly Met Asp Gly Ser Ser Arg Phe Ile Ile 
                165                 170                 175     


Ile Asn Ser Glu Ile Tyr Trp Pro Asn Gly Leu Thr Leu Asp Tyr Glu 
            180                 185                 190         


Glu Gln Lys Leu Tyr Trp Ala Asp Ala Lys Leu Asn Phe Ile His Lys 
        195                 200                 205             


Ser Asn Leu Asp Gly Thr Asn Arg Gln Ala Val Val Lys Gly Ser Leu 
    210                 215                 220                 


Pro His Pro Phe Ala Leu Thr Leu Phe Glu Asp Ile Leu Tyr Trp Thr 
225                 230                 235                 240 


Asp Trp Ser Thr His Ser Ile Leu Ala Cys Asn Lys Tyr Thr Gly Glu 
                245                 250                 255     


Gly Leu Arg Glu Ile His Ser Asp Ile Phe Ser Pro Met Asp Ile His 
            260                 265                 270         


Ala Phe Ser Gln Gln Arg Gln Pro Asn Ala Thr Asn Pro Cys Gly Ile 
        275                 280                 285             


Asp Asn Gly Gly Cys Ser His Leu Cys Leu Met Ser Pro Val Lys Pro 
    290                 295                 300                 


Phe Tyr Gln Cys Ala Cys Pro Thr Gly Val Lys Leu Leu Glu Asn Gly 
305                 310                 315                 320 


Lys Thr Cys Lys Asp Gly Ala Thr Glu Leu Leu Leu Leu Ala Arg Arg 
                325                 330                 335     


Thr Asp Leu Arg Arg Ile Ser Leu Asp Thr Pro Asp Phe Thr Asp Ile 
            340                 345                 350         


Val Leu Gln Leu Glu Asp Ile Arg His Ala Ile Ala Ile Asp Tyr Asp 
        355                 360                 365             


Pro Val Glu Gly Tyr Ile Tyr Trp Thr Asp Asp Glu Val Arg Ala Ile 
    370                 375                 380                 


Arg Arg Ser Phe Ile Asp Gly Ser Gly Ser Gln Phe Val Val Thr Ala 
385                 390                 395                 400 


Gln Ile Ala His Pro Asp Gly Ile Ala Val Asp Trp Val Ala Arg Asn 
                405                 410                 415     


Leu Tyr Trp Thr Asp Thr Gly Thr Asp Arg Ile Glu Val Thr Arg Leu 
            420                 425                 430         


Asn Gly Thr Met Arg Lys Ile Leu Ile Ser Glu Asp Leu Glu Glu Pro 
        435                 440                 445             


Arg Ala Ile Val Leu Asp Pro Met Val Gly Tyr Met Tyr Trp Thr Asp 
    450                 455                 460                 


Trp Gly Glu Ile Pro Lys Ile Glu Arg Ala Ala Leu Asp Gly Ser Asp 
465                 470                 475                 480 


Arg Val Val Leu Val Asn Thr Ser Leu Gly Trp Pro Asn Gly Leu Ala 
                485                 490                 495     


Leu Asp Tyr Asp Glu Gly Lys Ile Tyr Trp Gly Asp Ala Lys Thr Asp 
            500                 505                 510         


Lys Ile Glu Val Met Asn Thr Asp Gly Thr Gly Arg Arg Val Leu Val 
        515                 520                 525             


Glu Asp Lys Ile Pro His Ile Phe Gly Phe Thr Leu Leu Gly Asp Tyr 
    530                 535                 540                 


Val Tyr Trp Thr Asp Trp Gln Arg Arg Ser Ile Glu Arg Val His Lys 
545                 550                 555                 560 


Arg Ser Ala Glu Arg Glu Val Ile Ile Asp Gln Leu Pro Asp Leu Met 
                565                 570                 575     


Gly Leu Lys Ala Thr Asn Val His Arg Val Ile Gly Ser Asn Pro Cys 
            580                 585                 590         


Ala Glu Glu Asn Gly Gly Cys Ser His Leu Cys Leu Tyr Arg Pro Gln 
        595                 600                 605             


Gly Leu Arg Cys Ala Cys Pro Ile Gly Phe Glu Leu Ile Ser Asp Met 
    610                 615                 620                 


Lys Thr Cys Ile Val Pro Glu Ala Phe Leu Leu Phe Ser Arg Arg Ala 
625                 630                 635                 640 


Asp Ile Arg Arg Ile Ser Leu Glu Thr Asn Asn Asn Asn Val Ala Ile 
                645                 650                 655     


Pro Leu Thr Gly Val Lys Glu Ala Ser Ala Leu Asp Phe Asp Val Thr 
            660                 665                 670         


Asp Asn Arg Ile Tyr Trp Thr Asp Ile Ser Leu Lys Thr Ile Ser Arg 
        675                 680                 685             


Ala Phe Met Asn Gly Ser Ala Leu Glu His Val Val Glu Phe Gly Leu 
    690                 695                 700                 


Asp Tyr Pro Glu Gly Met Ala Val Asp Trp Leu Gly Lys Asn Leu Tyr 
705                 710                 715                 720 


Trp Ala Asp Thr Gly Thr Asn Arg Ile Glu Val Ser Lys Leu Asp Gly 
                725                 730                 735     


Gln His Arg Gln Val Leu Val Trp Lys Asp Leu Asp Ser Pro Arg Ala 
            740                 745                 750         


Leu Ala Leu Asp Pro Ala Glu Gly Phe Met Tyr Trp Thr Glu Trp Gly 
        755                 760                 765             


Gly Lys Pro Lys Ile Asp Arg Ala Ala Met Asp Gly Ser Glu Arg Thr 
    770                 775                 780                 


Thr Leu Val Pro Asn Val Gly Arg Ala Asn Gly Leu Thr Ile Asp Tyr 
785                 790                 795                 800 


Ala Lys Arg Arg Leu Tyr Trp Thr Asp Leu Asp Thr Asn Leu Ile Glu 
                805                 810                 815     


Ser Ser Asn Met Leu Gly Leu Asn Arg Glu Val Ile Ala Asp Asp Leu 
            820                 825                 830         


Pro His Pro Phe Gly Leu Thr Gln Tyr Gln Asp Tyr Ile Tyr Trp Thr 
        835                 840                 845             


Asp Trp Ser Arg Arg Ser Ile Glu Arg Ala Asn Lys Thr Ser Gly Gln 
    850                 855                 860                 


Asn Arg Thr Ile Ile Gln Gly His Leu Asp Tyr Val Met Asp Ile Leu 
865                 870                 875                 880 


Val Phe His Ser Ser Arg Gln Ser Gly Trp Asn Glu Cys Ala Ser Ser 
                885                 890                 895     


Asn Gly His Cys Ser His Leu Cys Leu Ala Val Pro Val Gly Gly Phe 
            900                 905                 910         


Val Cys Gly Cys Pro Ala His Tyr Ser Leu Asn Ala Asp Asn Arg Thr 
        915                 920                 925             


Cys Ser Ala Pro Thr Thr Phe Leu Leu Phe Ser Gln Lys Ser Ala Ile 
    930                 935                 940                 


Asn Arg Met Val Ile Asp Glu Gln Gln Ser Pro Asp Ile Ile Leu Pro 
945                 950                 955                 960 


Ile His Ser Leu Arg Asn Val Arg Ala Ile Asp Tyr Asp Pro Leu Asp 
                965                 970                 975     


Lys Gln Leu Tyr Trp Ile Asp Ser Arg Gln Asn Met Ile Arg Lys Ala 
            980                 985                 990         


Gln Glu Asp Gly Ser Gln Gly Phe  Thr Val Val Val Ser  Ser Val Pro 
        995                 1000                 1005             


Ser Gln  Asn Leu Glu Ile Gln  Pro Tyr Asp Leu Ser  Ile Asp Ile 
    1010                 1015                 1020             


Tyr Ser  Arg Tyr Ile Tyr Trp  Thr Cys Glu Ala Thr  Asn Val Ile 
    1025                 1030                 1035             


Asn Val  Thr Arg Leu Asp Gly  Arg Ser Val Gly Val  Val Leu Lys 
    1040                 1045                 1050             


Gly Glu  Gln Asp Arg Pro Arg  Ala Val Val Val Asn  Pro Glu Lys 
    1055                 1060                 1065             


Gly Tyr  Met Tyr Phe Thr Asn  Leu Gln Glu Arg Ser  Pro Lys Ile 
    1070                 1075                 1080             


Glu Arg  Ala Ala Leu Asp Gly  Thr Glu Arg Glu Val  Leu Phe Phe 
    1085                 1090                 1095             


Ser Gly  Leu Ser Lys Pro Ile  Ala Leu Ala Leu Asp  Ser Arg Leu 
    1100                 1105                 1110             


Gly Lys  Leu Phe Trp Ala Asp  Ser Asp Leu Arg Arg  Ile Glu Ser 
    1115                 1120                 1125             


Ser Asp  Leu Ser Gly Ala Asn  Arg Ile Val Leu Glu  Asp Ser Asn 
    1130                 1135                 1140             


Ile Leu  Gln Pro Val Gly Leu  Thr Val Phe Glu Asn  Trp Leu Tyr 
    1145                 1150                 1155             


Trp Ile  Asp Lys Gln Gln Gln  Met Ile Glu Lys Ile  Asp Met Thr 
    1160                 1165                 1170             


Gly Arg  Glu Gly Arg Thr Lys  Val Gln Ala Arg Ile  Ala Gln Leu 
    1175                 1180                 1185             


Ser Asp  Ile His Ala Val Lys  Glu Leu Asn Leu Gln  Glu Tyr Arg 
    1190                 1195                 1200             


Gln His  Pro Cys Ala Gln Asp  Asn Gly Gly Cys Ser  His Ile Cys 
    1205                 1210                 1215             


Leu Val  Lys Gly Asp Gly Thr  Thr Arg Cys Ser Cys  Pro Met His 
    1220                 1225                 1230             


Leu Val  Leu Leu Gln Asp Glu  Leu Ser Cys Gly Glu  Pro Pro Thr 
    1235                 1240                 1245             


Cys Ser  Pro Gln Gln Phe Thr  Cys Phe Thr Gly Glu  Ile Asp Cys 
    1250                 1255                 1260             


Ile Pro  Val Ala Trp Arg Cys  Asp Gly Phe Thr Glu  Cys Glu Asp 
    1265                 1270                 1275             


His Ser  Asp Glu Leu Asn Cys  Pro Val Cys Ser Glu  Ser Gln Phe 
    1280                 1285                 1290             


Gln Cys  Ala Ser Gly Gln Cys  Ile Asp Gly Ala Leu  Arg Cys Asn 
    1295                 1300                 1305             


Gly Asp  Ala Asn Cys Gln Asp  Lys Ser Asp Glu Lys  Asn Cys Glu 
    1310                 1315                 1320             


Val Leu  Cys Leu Ile Asp Gln  Phe Arg Cys Ala Asn  Gly Gln Cys 
    1325                 1330                 1335             


Ile Gly  Lys His Lys Lys Cys  Asp His Asn Val Asp  Cys Ser Asp 
    1340                 1345                 1350             


Lys Ser  Asp Glu Leu Asp Cys  Tyr Pro Thr Glu Glu  Pro Ala Pro 
    1355                 1360                 1365             


Gln Ala  Thr Asn Thr Val Gly  Ser Val Ile Gly Val  Ile Val Thr 
    1370                 1375                 1380             


Ile Phe  Val Ser Gly Thr Val  Tyr Phe Ile Cys Gln  Arg Met Leu 
    1385                 1390                 1395             


Cys Pro  Arg Met Lys Gly Asp  Gly Glu Thr Met Thr  Asn Asp Tyr 
    1400                 1405                 1410             


Val Val  His Gly Pro Ala Ser  Val Pro Leu Gly Tyr  Val Pro His 
    1415                 1420                 1425             


Pro Ser  Ser Leu Ser Gly Ser  Leu Pro Gly Met Ser  Arg Gly Lys 
    1430                 1435                 1440             


Ser Met  Ile Ser Ser Leu Ser  Ile Met Gly Gly Ser  Ser Gly Pro 
    1445                 1450                 1455             


Pro Tyr  Asp Arg Ala His Val  Thr Gly Ala Ser Ser  Ser Ser Ser 
    1460                 1465                 1470             


Ser Ser  Thr Lys Gly Thr Tyr  Phe Pro Ala Ile Leu  Asn Pro Pro 
    1475                 1480                 1485             


Pro Ser  Pro Ala Thr Glu Arg  Ser His Tyr Thr Met  Glu Phe Gly 
    1490                 1495                 1500             


Tyr Ser  Ser Asn Ser Pro Ser  Thr His Arg Ser Tyr  Ser Tyr Arg 
    1505                 1510                 1515             


Pro Tyr  Ser Tyr Arg His Phe  Ala Pro Pro Thr Thr  Pro Cys Ser 
    1520                 1525                 1530             


Thr Asp  Val Cys Asp Ser Asp  Tyr Ala Pro Ser Arg  Arg Met Thr 
    1535                 1540                 1545             


Ser Val  Ala Thr Ala Lys Gly  Tyr Thr Ser Asp Leu  Asn Tyr Asp 
    1550                 1555                 1560             


Ser Glu  Pro Val Pro Pro Pro  Pro Thr Pro Arg Ser  Gln Tyr Leu 
    1565                 1570                 1575             


Ser Ala  Glu Glu Asn Tyr Glu  Ser Cys Pro Pro Ser  Pro Tyr Thr 
    1580                 1585                 1590             


Glu Arg  Ser Tyr Ser His His  Leu Tyr Pro Pro Pro  Pro Ser Pro 
    1595                 1600                 1605             


Cys Thr  Asp Ser Ser 
    1610             


<210>  26
<211>  4599
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Glu Phe Leu Leu Ala Leu Leu Thr Leu Ser Gly Leu Leu Pro 
1               5                   10                  15      


Ile Ala Arg Val Leu Thr Val Gly Ala Asp Arg Asp Gln Gln Leu Cys 
            20                  25                  30          


Asp Pro Gly Glu Phe Leu Cys His Asp His Val Thr Cys Val Ser Gln 
        35                  40                  45              


Ser Trp Leu Cys Asp Gly Asp Pro Asp Cys Pro Asp Asp Ser Asp Glu 
    50                  55                  60                  


Ser Leu Asp Thr Cys Pro Glu Glu Val Glu Ile Lys Cys Pro Leu Asn 
65                  70                  75                  80  


His Ile Ala Cys Leu Gly Thr Asn Lys Cys Val His Leu Ser Gln Leu 
                85                  90                  95      


Cys Asn Gly Val Leu Asp Cys Pro Asp Gly Tyr Asp Glu Gly Val His 
            100                 105                 110         


Cys Gln Glu Leu Leu Ser Asn Cys Gln Gln Leu Asn Cys Gln Tyr Lys 
        115                 120                 125             


Cys Thr Met Val Arg Asn Ser Thr Arg Cys Tyr Cys Glu Asp Gly Phe 
    130                 135                 140                 


Glu Ile Thr Glu Asp Gly Arg Ser Cys Lys Asp Gln Asp Glu Cys Ala 
145                 150                 155                 160 


Val Tyr Gly Thr Cys Ser Gln Thr Cys Arg Asn Thr His Gly Ser Tyr 
                165                 170                 175     


Thr Cys Ser Cys Val Glu Gly Tyr Leu Met Gln Pro Asp Asn Arg Ser 
            180                 185                 190         


Cys Lys Ala Lys Ile Glu Pro Thr Asp Arg Pro Pro Ile Leu Leu Ile 
        195                 200                 205             


Ala Asn Phe Glu Thr Ile Glu Val Phe Tyr Leu Asn Gly Ser Lys Met 
    210                 215                 220                 


Ala Thr Leu Ser Ser Val Asn Gly Asn Glu Ile His Thr Leu Asp Phe 
225                 230                 235                 240 


Ile Tyr Asn Glu Asp Met Ile Cys Trp Ile Glu Ser Arg Glu Ser Ser 
                245                 250                 255     


Asn Gln Leu Lys Cys Ile Gln Ile Thr Lys Ala Gly Gly Leu Thr Asp 
            260                 265                 270         


Glu Trp Thr Ile Asn Ile Leu Gln Ser Phe His Asn Val Gln Gln Met 
        275                 280                 285             


Ala Ile Asp Trp Leu Thr Arg Asn Leu Tyr Phe Val Asp His Val Gly 
    290                 295                 300                 


Asp Arg Ile Phe Val Cys Asn Ser Asn Gly Ser Val Cys Val Thr Leu 
305                 310                 315                 320 


Ile Asp Leu Glu Leu His Asn Pro Lys Ala Ile Ala Val Asp Pro Ile 
                325                 330                 335     


Ala Gly Lys Leu Phe Phe Thr Asp Tyr Gly Asn Val Ala Lys Val Glu 
            340                 345                 350         


Arg Cys Asp Met Asp Gly Met Asn Arg Thr Arg Ile Ile Asp Ser Lys 
        355                 360                 365             


Thr Glu Gln Pro Ala Ala Leu Ala Leu Asp Leu Val Asn Lys Leu Val 
    370                 375                 380                 


Tyr Trp Val Asp Leu Tyr Leu Asp Tyr Val Gly Val Val Asp Tyr Gln 
385                 390                 395                 400 


Gly Lys Asn Arg His Thr Val Ile Gln Gly Arg Gln Val Arg His Leu 
                405                 410                 415     


Tyr Gly Ile Thr Val Phe Glu Asp Tyr Leu Tyr Ala Thr Asn Ser Asp 
            420                 425                 430         


Asn Tyr Asn Ile Val Arg Ile Asn Arg Phe Asn Gly Thr Asp Ile His 
        435                 440                 445             


Ser Leu Ile Lys Ile Glu Asn Ala Trp Gly Ile Arg Ile Tyr Gln Lys 
    450                 455                 460                 


Arg Thr Gln Pro Thr Val Arg Ser His Ala Cys Glu Val Asp Pro Tyr 
465                 470                 475                 480 


Gly Met Pro Gly Gly Cys Ser His Ile Cys Leu Leu Ser Ser Ser Tyr 
                485                 490                 495     


Lys Thr Arg Thr Cys Arg Cys Arg Thr Gly Phe Asn Leu Gly Ser Asp 
            500                 505                 510         


Gly Arg Ser Cys Lys Arg Pro Lys Asn Glu Leu Phe Leu Phe Tyr Gly 
        515                 520                 525             


Lys Gly Arg Pro Gly Ile Val Arg Gly Met Asp Leu Asn Thr Lys Ile 
    530                 535                 540                 


Ala Asp Glu Tyr Met Ile Pro Ile Glu Asn Leu Val Asn Pro Arg Ala 
545                 550                 555                 560 


Leu Asp Phe His Ala Glu Thr Asn Tyr Ile Tyr Phe Ala Asp Thr Thr 
                565                 570                 575     


Ser Phe Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu Arg Glu Thr 
            580                 585                 590         


Ile Leu Lys Asp Asp Leu Asp Asn Val Glu Gly Ile Ala Val Asp Trp 
        595                 600                 605             


Ile Gly Asn Asn Leu Tyr Trp Thr Asn Asp Gly His Arg Lys Thr Ile 
    610                 615                 620                 


Asn Val Ala Arg Leu Glu Lys Ala Ser Gln Ser Arg Lys Thr Leu Leu 
625                 630                 635                 640 


Glu Gly Glu Met Ser His Pro Arg Gly Ile Val Val Asp Pro Val Asn 
                645                 650                 655     


Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Glu Ile Asp Asp Ser 
            660                 665                 670         


Val Gly Arg Ile Glu Lys Ala Trp Met Asp Gly Phe Asn Arg Gln Ile 
        675                 680                 685             


Phe Val Thr Ser Lys Met Leu Trp Pro Asn Gly Leu Thr Leu Asp Phe 
    690                 695                 700                 


His Thr Asn Thr Leu Tyr Trp Cys Asp Ala Tyr Tyr Asp His Ile Glu 
705                 710                 715                 720 


Lys Val Phe Leu Asn Gly Thr His Arg Lys Ile Val Tyr Ser Gly Arg 
                725                 730                 735     


Glu Leu Asn His Pro Phe Gly Leu Ser His His Gly Asn Tyr Val Phe 
            740                 745                 750         


Trp Thr Asp Tyr Met Asn Gly Ser Ile Phe Gln Leu Asp Leu Ile Thr 
        755                 760                 765             


Ser Glu Val Thr Leu Leu Arg His Glu Arg Pro Pro Leu Phe Gly Leu 
    770                 775                 780                 


Gln Ile Tyr Asp Pro Arg Lys Gln Gln Gly Asp Asn Met Cys Arg Val 
785                 790                 795                 800 


Asn Asn Gly Gly Cys Ser Thr Leu Cys Leu Ala Ile Pro Gly Gly Arg 
                805                 810                 815     


Val Cys Ala Cys Ala Asp Asn Gln Leu Leu Asp Glu Asn Gly Thr Thr 
            820                 825                 830         


Cys Thr Phe Asn Pro Gly Glu Ala Leu Pro His Ile Cys Lys Ala Gly 
        835                 840                 845             


Glu Phe Arg Cys Lys Asn Arg His Cys Ile Gln Ala Arg Trp Lys Cys 
    850                 855                 860                 


Asp Gly Asp Asp Asp Cys Leu Asp Gly Ser Asp Glu Asp Ser Val Asn 
865                 870                 875                 880 


Cys Phe Asn His Ser Cys Pro Asp Asp Gln Phe Lys Cys Gln Asn Asn 
                885                 890                 895     


Arg Cys Ile Pro Lys Arg Trp Leu Cys Asp Gly Ala Asn Asp Cys Gly 
            900                 905                 910         


Ser Asn Glu Asp Glu Ser Asn Gln Thr Cys Thr Ala Arg Thr Cys Gln 
        915                 920                 925             


Val Asp Gln Phe Ser Cys Gly Asn Gly Arg Cys Ile Pro Arg Ala Trp 
    930                 935                 940                 


Leu Cys Asp Arg Glu Asp Asp Cys Gly Asp Gln Thr Asp Glu Met Ala 
945                 950                 955                 960 


Ser Cys Glu Phe Pro Thr Cys Glu Pro Leu Thr Gln Phe Val Cys Lys 
                965                 970                 975     


Ser Gly Arg Cys Ile Ser Ser Lys Trp His Cys Asp Ser Asp Asp Asp 
            980                 985                 990         


Cys Gly Asp Gly Ser Asp Glu Val  Gly Cys Val His Ser  Cys Phe Asp 
        995                 1000                 1005             


Asn Gln  Phe Arg Cys Ser Ser  Gly Arg Cys Ile Pro  Gly His Trp 
    1010                 1015                 1020             


Ala Cys  Asp Gly Asp Asn Asp  Cys Gly Asp Phe Ser  Asp Glu Ala 
    1025                 1030                 1035             


Gln Ile  Asn Cys Thr Lys Glu  Glu Ile His Ser Pro  Ala Gly Cys 
    1040                 1045                 1050             


Asn Gly  Asn Glu Phe Gln Cys  His Pro Asp Gly Asn  Cys Val Pro 
    1055                 1060                 1065             


Asp Leu  Trp Arg Cys Asp Gly  Glu Lys Asp Cys Glu  Asp Gly Ser 
    1070                 1075                 1080             


Asp Glu  Lys Gly Cys Asn Gly  Thr Ile Arg Leu Cys  Asp His Lys 
    1085                 1090                 1095             


Thr Lys  Phe Ser Cys Trp Ser  Thr Gly Arg Cys Ile  Asn Lys Ala 
    1100                 1105                 1110             


Trp Val  Cys Asp Gly Asp Ile  Asp Cys Glu Asp Gln  Ser Asp Glu 
    1115                 1120                 1125             


Asp Asp  Cys Asp Ser Phe Leu  Cys Gly Pro Pro Lys  His Pro Cys 
    1130                 1135                 1140             


Ala Asn  Asp Thr Ser Val Cys  Leu Gln Pro Glu Lys  Leu Cys Asn 
    1145                 1150                 1155             


Gly Lys  Lys Asp Cys Pro Asp  Gly Ser Asp Glu Gly  Tyr Leu Cys 
    1160                 1165                 1170             


Asp Glu  Cys Ser Leu Asn Asn  Gly Gly Cys Ser Asn  His Cys Ser 
    1175                 1180                 1185             


Val Val  Pro Gly Arg Gly Ile  Val Cys Ser Cys Pro  Glu Gly Leu 
    1190                 1195                 1200             


Gln Leu  Asn Lys Asp Asn Lys  Thr Cys Glu Ile Val  Asp Tyr Cys 
    1205                 1210                 1215             


Ser Asn  His Leu Lys Cys Ser  Gln Val Cys Glu Gln  His Lys His 
    1220                 1225                 1230             


Thr Val  Lys Cys Ser Cys Tyr  Glu Gly Trp Lys Leu  Asp Val Asp 
    1235                 1240                 1245             


Gly Glu  Ser Cys Thr Ser Val  Asp Pro Phe Glu Ala  Phe Ile Ile 
    1250                 1255                 1260             


Phe Ser  Ile Arg His Glu Ile  Arg Arg Ile Asp Leu  His Lys Arg 
    1265                 1270                 1275             


Asp Tyr  Ser Leu Leu Val Pro  Gly Leu Arg Asn Thr  Ile Ala Leu 
    1280                 1285                 1290             


Asp Phe  His Phe Asn Gln Ser  Leu Leu Tyr Trp Thr  Asp Val Val 
    1295                 1300                 1305             


Glu Asp  Arg Ile Tyr Arg Gly  Lys Leu Ser Glu Ser  Gly Gly Val 
    1310                 1315                 1320             


Ser Ala  Ile Glu Val Val Val  Glu His Gly Leu Ala  Thr Pro Glu 
    1325                 1330                 1335             


Gly Leu  Thr Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Ile Asp 
    1340                 1345                 1350             


Ser Asn  Leu Asp Gln Ile Glu  Val Ala Lys Leu Asp  Gly Ser Leu 
    1355                 1360                 1365             


Arg Thr  Thr Leu Ile Ala Gly  Ala Met Glu His Pro  Arg Ala Ile 
    1370                 1375                 1380             


Ala Leu  Asp Pro Arg Tyr Gly  Ile Leu Phe Trp Thr  Asp Trp Asp 
    1385                 1390                 1395             


Ala Asn  Phe Pro Arg Ile Glu  Ser Ala Ser Met Ser  Gly Ala Gly 
    1400                 1405                 1410             


Arg Lys  Thr Ile Tyr Lys Asp  Met Lys Thr Gly Ala  Trp Pro Asn 
    1415                 1420                 1425             


Gly Leu  Thr Val Asp His Phe  Glu Lys Arg Ile Val  Trp Thr Asp 
    1430                 1435                 1440             


Ala Arg  Ser Asp Ala Ile Tyr  Ser Ala Leu Tyr Asp  Gly Thr Asn 
    1445                 1450                 1455             


Met Ile  Glu Ile Ile Arg Gly  His Glu Tyr Leu Ser  His Pro Phe 
    1460                 1465                 1470             


Ala Val  Ser Leu Tyr Gly Ser  Glu Val Tyr Trp Thr  Asp Trp Arg 
    1475                 1480                 1485             


Thr Asn  Thr Leu Ser Lys Ala  Asn Lys Trp Thr Gly  Gln Asn Val 
    1490                 1495                 1500             


Ser Val  Ile Gln Lys Thr Ser  Ala Gln Pro Phe Asp  Leu Gln Ile 
    1505                 1510                 1515             


Tyr His  Pro Ser Arg Gln Pro  Gln Ala Pro Asn Pro  Cys Ala Ala 
    1520                 1525                 1530             


Asn Asp  Gly Lys Gly Pro Cys  Ser His Met Cys Leu  Ile Asn His 
    1535                 1540                 1545             


Asn Arg  Ser Ala Ala Cys Ala  Cys Pro His Leu Met  Lys Leu Ser 
    1550                 1555                 1560             


Ser Asp  Lys Lys Thr Cys Tyr  Glu Met Lys Lys Phe  Leu Leu Tyr 
    1565                 1570                 1575             


Ala Arg  Arg Ser Glu Ile Arg  Gly Val Asp Ile Asp  Asn Pro Tyr 
    1580                 1585                 1590             


Phe Asn  Phe Ile Thr Ala Phe  Thr Val Pro Asp Ile  Asp Asp Val 
    1595                 1600                 1605             


Thr Val  Ile Asp Phe Asp Ala  Ser Glu Glu Arg Leu  Tyr Trp Thr 
    1610                 1615                 1620             


Asp Ile  Lys Thr Gln Thr Ile  Lys Arg Ala Phe Ile  Asn Gly Thr 
    1625                 1630                 1635             


Gly Leu  Glu Thr Val Ile Ser  Arg Asp Ile Gln Ser  Ile Arg Gly 
    1640                 1645                 1650             


Leu Ala  Val Asp Trp Val Ser  Arg Asn Leu Tyr Trp  Ile Ser Ser 
    1655                 1660                 1665             


Glu Phe  Asp Glu Thr Gln Ile  Asn Val Ala Arg Leu  Asp Gly Ser 
    1670                 1675                 1680             


Leu Lys  Thr Ser Ile Ile His  Gly Ile Asp Lys Pro  Gln Cys Leu 
    1685                 1690                 1695             


Ala Ala  His Pro Val Arg Gly  Lys Leu Tyr Trp Thr  Asp Gly Asn 
    1700                 1705                 1710             


Thr Ile  Asn Met Ala Asn Met  Asp Gly Ser Asn Ser  Lys Ile Leu 
    1715                 1720                 1725             


Phe Gln  Asn Gln Lys Glu Pro  Val Gly Leu Ser Ile  Asp Tyr Val 
    1730                 1735                 1740             


Glu Asn  Lys Leu Tyr Trp Ile  Ser Ser Gly Asn Gly  Thr Ile Asn 
    1745                 1750                 1755             


Arg Cys  Asn Leu Asp Gly Gly  Asn Leu Glu Val Ile  Glu Ser Met 
    1760                 1765                 1770             


Lys Glu  Glu Leu Thr Lys Ala  Thr Ala Leu Thr Ile  Met Asp Lys 
    1775                 1780                 1785             


Lys Leu  Trp Trp Ala Asp Gln  Asn Leu Ala Gln Leu  Gly Thr Cys 
    1790                 1795                 1800             


Ser Lys  Arg Asp Gly Arg Asn  Pro Thr Ile Leu Arg  Asn Lys Thr 
    1805                 1810                 1815             


Ser Gly  Val Val His Met Lys  Val Tyr Asp Lys Glu  Ala Gln Gln 
    1820                 1825                 1830             


Gly Ser  Asn Ser Cys Gln Leu  Asn Asn Gly Gly Cys  Ser Gln Leu 
    1835                 1840                 1845             


Cys Leu  Pro Thr Ser Glu Thr  Thr Arg Thr Cys Met  Cys Thr Val 
    1850                 1855                 1860             


Gly Tyr  Tyr Leu Gln Lys Asn  Arg Met Ser Cys Gln  Gly Ile Glu 
    1865                 1870                 1875             


Ser Phe  Leu Met Tyr Ser Val  His Glu Gly Ile Arg  Gly Ile Pro 
    1880                 1885                 1890             


Leu Glu  Pro Ser Asp Lys Met  Asp Ala Leu Met Pro  Ile Ser Gly 
    1895                 1900                 1905             


Thr Ser  Phe Ala Val Gly Ile  Asp Phe His Ala Glu  Asn Asp Thr 
    1910                 1915                 1920             


Ile Tyr  Trp Thr Asp Met Gly  Phe Asn Lys Ile Ser  Arg Ala Lys 
    1925                 1930                 1935             


Arg Asp  Gln Thr Trp Lys Glu  Asp Ile Ile Thr Asn  Gly Leu Gly 
    1940                 1945                 1950             


Arg Val  Glu Gly Ile Ala Val  Asp Trp Ile Ala Gly  Asn Ile Tyr 
    1955                 1960                 1965             


Trp Thr  Asp His Gly Phe Asn  Leu Ile Glu Val Ala  Arg Leu Asn 
    1970                 1975                 1980             


Gly Ser  Phe Arg Tyr Val Ile  Ile Ser Gln Gly Leu  Asp Gln Pro 
    1985                 1990                 1995             


Arg Ser  Ile Ala Val His Pro  Glu Lys Gly Leu Leu  Phe Trp Thr 
    2000                 2005                 2010             


Glu Trp  Gly Gln Met Pro Cys  Ile Gly Lys Ala Arg  Leu Asp Gly 
    2015                 2020                 2025             


Ser Glu  Lys Val Val Leu Val  Ser Met Gly Ile Ala  Trp Pro Asn 
    2030                 2035                 2040             


Gly Ile  Ser Ile Asp Tyr Glu  Glu Asn Lys Leu Tyr  Trp Cys Asp 
    2045                 2050                 2055             


Ala Arg  Thr Asp Lys Ile Glu  Arg Ile Asp Leu Glu  Thr Gly Gly 
    2060                 2065                 2070             


Asn Arg  Glu Met Val Leu Ser  Gly Ser Asn Val Asp  Met Phe Ser 
    2075                 2080                 2085             


Val Ala  Val Phe Gly Ala Tyr  Ile Tyr Trp Ser Asp  Arg Ala His 
    2090                 2095                 2100             


Ala Asn  Gly Ser Val Arg Arg  Gly His Lys Asn Asp  Ala Thr Glu 
    2105                 2110                 2115             


Thr Ile  Thr Met Arg Thr Gly  Leu Gly Val Asn Leu  Lys Glu Val 
    2120                 2125                 2130             


Lys Ile  Phe Asn Arg Val Arg  Glu Lys Gly Thr Asn  Val Cys Ala 
    2135                 2140                 2145             


Arg Asp  Asn Gly Gly Cys Lys  Gln Leu Cys Leu Tyr  Arg Gly Asn 
    2150                 2155                 2160             


Ser Arg  Arg Thr Cys Ala Cys  Ala His Gly Tyr Leu  Ala Glu Asp 
    2165                 2170                 2175             


Gly Val  Thr Cys Leu Arg His  Glu Gly Tyr Leu Leu  Tyr Ser Gly 
    2180                 2185                 2190             


Arg Thr  Ile Leu Lys Ser Ile  His Leu Ser Asp Glu  Thr Asn Leu 
    2195                 2200                 2205             


Asn Ser  Pro Ile Arg Pro Tyr  Glu Asn Pro Arg Tyr  Phe Lys Asn 
    2210                 2215                 2220             


Val Ile  Ala Leu Ala Phe Asp  Tyr Asn Gln Arg Arg  Lys Gly Thr 
    2225                 2230                 2235             


Asn Arg  Ile Phe Tyr Ser Asp  Ala His Phe Gly Asn  Ile Gln Leu 
    2240                 2245                 2250             


Ile Lys  Asp Asn Trp Glu Asp  Arg Gln Val Ile Val  Glu Asn Val 
    2255                 2260                 2265             


Gly Ser  Val Glu Gly Leu Ala  Tyr His Arg Ala Trp  Asp Thr Leu 
    2270                 2275                 2280             


Tyr Trp  Thr Ser Ser Thr Thr  Ser Ser Ile Thr Arg  His Thr Val 
    2285                 2290                 2295             


Asp Gln  Thr Arg Pro Gly Ala  Phe Asp Arg Glu Ala  Val Ile Thr 
    2300                 2305                 2310             


Met Ser  Glu Asp Asp His Pro  His Val Leu Ala Leu  Asp Glu Cys 
    2315                 2320                 2325             


Gln Asn  Leu Met Phe Trp Thr  Asn Trp Asn Glu Gln  His Pro Ser 
    2330                 2335                 2340             


Ile Met  Arg Ser Thr Leu Thr  Gly Lys Asn Ala Gln  Val Val Val 
    2345                 2350                 2355             


Ser Thr  Asp Ile Leu Thr Pro  Asn Gly Leu Thr Ile  Asp Tyr Arg 
    2360                 2365                 2370             


Ala Glu  Lys Leu Tyr Phe Ser  Asp Gly Ser Leu Gly  Lys Ile Glu 
    2375                 2380                 2385             


Arg Cys  Glu Tyr Asp Gly Ser  Gln Arg His Val Ile  Val Lys Ser 
    2390                 2395                 2400             


Gly Pro  Gly Thr Phe Leu Ser  Leu Ala Val Tyr Asp  Asn Tyr Ile 
    2405                 2410                 2415             


Phe Trp  Ser Asp Trp Gly Arg  Arg Ala Ile Leu Arg  Ser Asn Lys 
    2420                 2425                 2430             


Tyr Thr  Gly Gly Asp Thr Lys  Ile Leu Arg Ser Asp  Ile Pro His 
    2435                 2440                 2445             


Gln Pro  Met Gly Ile Ile Ala  Val Ala Asn Asp Thr  Asn Ser Cys 
    2450                 2455                 2460             


Glu Leu  Ser Pro Cys Ala Leu  Leu Asn Gly Gly Cys  His Asp Leu 
    2465                 2470                 2475             


Cys Leu  Leu Thr Pro Asn Gly  Arg Val Asn Cys Ser  Cys Arg Gly 
    2480                 2485                 2490             


Asp Arg  Ile Leu Leu Glu Asp  Asn Arg Cys Val Thr  Lys Asn Ser 
    2495                 2500                 2505             


Ser Cys  Asn Ala Tyr Ser Glu  Phe Glu Cys Gly Asn  Gly Glu Cys 
    2510                 2515                 2520             


Ile Asp  Tyr Gln Leu Thr Cys  Asp Gly Ile Pro His  Cys Lys Asp 
    2525                 2530                 2535             


Lys Ser  Asp Glu Lys Leu Leu  Tyr Cys Glu Asn Arg  Ser Cys Arg 
    2540                 2545                 2550             


Arg Gly  Phe Lys Pro Cys Tyr  Asn Arg Arg Cys Ile  Pro His Gly 
    2555                 2560                 2565             


Lys Leu  Cys Asp Gly Glu Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
    2570                 2575                 2580             


Leu Asp  Cys Lys Val Ser Thr  Cys Ala Thr Val Glu  Phe Arg Cys 
    2585                 2590                 2595             


Ala Asp  Gly Thr Cys Ile Pro  Arg Ser Ala Arg Cys  Asn Gln Asn 
    2600                 2605                 2610             


Ile Asp  Cys Ala Asp Ala Ser  Asp Glu Lys Asn Cys  Asn Asn Thr 
    2615                 2620                 2625             


Asp Cys  Thr His Phe Tyr Lys  Leu Gly Val Lys Thr  Thr Gly Phe 
    2630                 2635                 2640             


Ile Arg  Cys Asn Ser Thr Ser  Leu Cys Val Leu Pro  Thr Trp Ile 
    2645                 2650                 2655             


Cys Asp  Gly Ser Asn Asp Cys  Gly Asp Tyr Ser Asp  Glu Leu Lys 
    2660                 2665                 2670             


Cys Pro  Val Gln Asn Lys His  Lys Cys Glu Glu Asn  Tyr Phe Ser 
    2675                 2680                 2685             


Cys Pro  Ser Gly Arg Cys Ile  Leu Asn Thr Trp Ile  Cys Asp Gly 
    2690                 2695                 2700             


Gln Lys  Asp Cys Glu Asp Gly  Arg Asp Glu Phe His  Cys Asp Ser 
    2705                 2710                 2715             


Ser Cys  Ser Trp Asn Gln Phe  Ala Cys Ser Ala Gln  Lys Cys Ile 
    2720                 2725                 2730             


Ser Lys  His Trp Ile Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly 
    2735                 2740                 2745             


Leu Asp  Glu Ser Asp Ser Ile  Cys Gly Ala Ile Thr  Cys Ala Ala 
    2750                 2755                 2760             


Asp Met  Phe Ser Cys Gln Gly  Ser Arg Ala Cys Val  Pro Arg His 
    2765                 2770                 2775             


Trp Leu  Cys Asp Gly Glu Arg  Asp Cys Pro Asp Gly  Ser Asp Glu 
    2780                 2785                 2790             


Leu Ser  Thr Ala Gly Cys Ala  Pro Asn Asn Thr Cys  Asp Glu Asn 
    2795                 2800                 2805             


Ala Phe  Met Cys His Asn Lys  Val Cys Ile Pro Lys  Gln Phe Val 
    2810                 2815                 2820             


Cys Asp  His Asp Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Ser Pro 
    2825                 2830                 2835             


Gln Cys  Gly Tyr Arg Gln Cys  Gly Thr Glu Glu Phe  Ser Cys Ala 
    2840                 2845                 2850             


Asp Gly  Arg Cys Leu Leu Asn  Thr Gln Trp Gln Cys  Asp Gly Asp 
    2855                 2860                 2865             


Phe Asp  Cys Pro Asp His Ser  Asp Glu Ala Pro Leu  Asn Pro Lys 
    2870                 2875                 2880             


Cys Lys  Ser Ala Glu Gln Ser  Cys Asn Ser Ser Phe  Phe Met Cys 
    2885                 2890                 2895             


Lys Asn  Gly Arg Cys Ile Pro  Ser Gly Gly Leu Cys  Asp Asn Lys 
    2900                 2905                 2910             


Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Arg Asn Cys  His Ile Asn 
    2915                 2920                 2925             


Glu Cys  Leu Ser Lys Lys Val  Ser Gly Cys Ser Gln  Asp Cys Gln 
    2930                 2935                 2940             


Asp Leu  Pro Val Ser Tyr Lys  Cys Lys Cys Trp Pro  Gly Phe Gln 
    2945                 2950                 2955             


Leu Lys  Asp Asp Gly Lys Thr  Cys Val Asp Ile Asp  Glu Cys Ser 
    2960                 2965                 2970             


Ser Gly  Phe Pro Cys Ser Gln  Gln Cys Ile Asn Thr  Tyr Gly Thr 
    2975                 2980                 2985             


Tyr Lys  Cys Leu Cys Thr Asp  Gly Tyr Glu Ile Gln  Pro Asp Asn 
    2990                 2995                 3000             


Pro Asn  Gly Cys Lys Ser Leu  Ser Asp Glu Glu Pro  Phe Leu Ile 
    3005                 3010                 3015             


Leu Ala  Asp His His Glu Ile  Arg Lys Ile Ser Thr  Asp Gly Ser 
    3020                 3025                 3030             


Asn Tyr  Thr Leu Leu Lys Gln  Gly Leu Asn Asn Val  Ile Ala Ile 
    3035                 3040                 3045             


Asp Phe  Asp Tyr Arg Glu Glu  Phe Ile Tyr Trp Ile  Asp Ser Ser 
    3050                 3055                 3060             


Arg Pro  Asn Gly Ser Arg Ile  Asn Arg Met Cys Leu  Asn Gly Ser 
    3065                 3070                 3075             


Asp Ile  Lys Val Val His Asn  Thr Ala Val Pro Asn  Ala Leu Ala 
    3080                 3085                 3090             


Val Asp  Trp Ile Gly Lys Asn  Leu Tyr Trp Ser Asp  Thr Glu Lys 
    3095                 3100                 3105             


Arg Ile  Ile Glu Val Ser Lys  Leu Asn Gly Leu Tyr  Pro Thr Ile 
    3110                 3115                 3120             


Leu Val  Ser Lys Arg Leu Lys  Phe Pro Arg Asp Leu  Ser Leu Asp 
    3125                 3130                 3135             


Pro Gln  Ala Gly Tyr Leu Tyr  Trp Ile Asp Cys Cys  Glu Tyr Pro 
    3140                 3145                 3150             


His Ile  Gly Arg Val Gly Met  Asp Gly Thr Asn Gln  Ser Val Val 
    3155                 3160                 3165             


Ile Glu  Thr Lys Ile Ser Arg  Pro Met Ala Leu Thr  Ile Asp Tyr 
    3170                 3175                 3180             


Val Asn  Arg Arg Leu Tyr Trp  Ala Asp Glu Asn His  Ile Glu Phe 
    3185                 3190                 3195             


Ser Asn  Met Asp Gly Ser His  Arg His Lys Val Pro  Asn Gln Asp 
    3200                 3205                 3210             


Ile Pro  Gly Val Ile Ala Leu  Thr Leu Phe Glu Asp  Tyr Ile Tyr 
    3215                 3220                 3225             


Trp Thr  Asp Gly Lys Thr Lys  Ser Leu Ser Arg Ala  His Lys Thr 
    3230                 3235                 3240             


Ser Gly  Ala Asp Arg Leu Ser  Leu Ile Tyr Ser Trp  His Ala Ile 
    3245                 3250                 3255             


Thr Asp  Ile Gln Val Tyr His  Ser Tyr Arg Gln Pro  Asp Val Ser 
    3260                 3265                 3270             


Lys His  Leu Cys Met Ile Asn  Asn Gly Gly Cys Ser  His Leu Cys 
    3275                 3280                 3285             


Leu Leu  Ala Pro Gly Lys Thr  His Thr Cys Ala Cys  Pro Thr Asn 
    3290                 3295                 3300             


Phe Tyr  Leu Ala Ala Asp Asn  Arg Thr Cys Leu Ser  Asn Cys Thr 
    3305                 3310                 3315             


Ala Ser  Gln Phe Arg Cys Lys  Thr Asp Lys Cys Ile  Pro Phe Trp 
    3320                 3325                 3330             


Trp Lys  Cys Asp Thr Val Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3335                 3340                 3345             


Pro Asp  Asp Cys Pro Glu Phe  Arg Cys Gln Pro Gly  Arg Phe Gln 
    3350                 3355                 3360             


Cys Gly  Thr Gly Leu Cys Ala  Leu Pro Ala Phe Ile  Cys Asp Gly 
    3365                 3370                 3375             


Glu Asn  Asp Cys Gly Asp Asn  Ser Asp Glu Leu Asn  Cys Asp Thr 
    3380                 3385                 3390             


His Val  Cys Leu Ser Gly Gln  Phe Lys Cys Thr Lys  Asn Gln Lys 
    3395                 3400                 3405             


Cys Ile  Pro Val Asn Leu Arg  Cys Asn Gly Gln Asp  Asp Cys Gly 
    3410                 3415                 3420             


Asp Glu  Glu Asp Glu Arg Asp  Cys Pro Glu Asn Ser  Cys Ser Pro 
    3425                 3430                 3435             


Asp Tyr  Phe Gln Cys Lys Thr  Thr Lys His Cys Ile  Ser Lys Leu 
    3440                 3445                 3450             


Trp Val  Cys Asp Glu Asp Pro  Asp Cys Ala Asp Ala  Ser Asp Glu 
    3455                 3460                 3465             


Ala Asn  Cys Asp Lys Lys Thr  Cys Gly Pro His Glu  Phe Gln Cys 
    3470                 3475                 3480             


Lys Asn  Asn Asn Cys Ile Pro  Asp His Trp Arg Cys  Asp Ser Gln 
    3485                 3490                 3495             


Asn Asp  Cys Ser Asp Asn Ser  Asp Glu Glu Asn Cys  Lys Pro Gln 
    3500                 3505                 3510             


Thr Cys  Thr Leu Lys Asp Phe  Leu Cys Ala Asn Gly  Asp Cys Val 
    3515                 3520                 3525             


Ser Ser  Arg Phe Trp Cys Asp  Gly Asp Phe Asp Cys  Ala Asp Gly 
    3530                 3535                 3540             


Ser Asp  Glu Arg Asn Cys Glu  Thr Ser Cys Ser Lys  Asp Gln Phe 
    3545                 3550                 3555             


Arg Cys  Ser Asn Gly Gln Cys  Ile Pro Ala Lys Trp  Lys Cys Asp 
    3560                 3565                 3570             


Gly His  Glu Asp Cys Lys Tyr  Gly Glu Asp Glu Lys  Ser Cys Glu 
    3575                 3580                 3585             


Pro Ala  Ser Pro Thr Cys Ser  Ser Arg Glu Tyr Ile  Cys Ala Ser 
    3590                 3595                 3600             


Asp Gly  Cys Ile Ser Ala Ser  Leu Lys Cys Asn Gly  Glu Tyr Asp 
    3605                 3610                 3615             


Cys Ala  Asp Gly Ser Asp Glu  Met Asp Cys Val Thr  Glu Cys Lys 
    3620                 3625                 3630             


Glu Asp  Gln Phe Arg Cys Lys  Asn Lys Ala His Cys  Ile Pro Ile 
    3635                 3640                 3645             


Arg Trp  Leu Cys Asp Gly Ile  His Asp Cys Val Asp  Gly Ser Asp 
    3650                 3655                 3660             


Glu Glu  Asn Cys Glu Arg Gly  Gly Asn Ile Cys Arg  Ala Asp Glu 
    3665                 3670                 3675             


Phe Leu  Cys Asn Asn Ser Leu  Cys Lys Leu His Phe  Trp Val Cys 
    3680                 3685                 3690             


Asp Gly  Glu Asp Asp Cys Gly  Asp Asn Ser Asp Glu  Ala Pro Asp 
    3695                 3700                 3705             


Met Cys  Val Lys Phe Leu Cys  Pro Ser Thr Arg Pro  His Arg Cys 
    3710                 3715                 3720             


Arg Asn  Asn Arg Ile Cys Leu  Gln Ser Glu Gln Met  Cys Asn Gly 
    3725                 3730                 3735             


Ile Asp  Glu Cys Gly Asp Asn  Ser Asp Glu Asp His  Cys Gly Gly 
    3740                 3745                 3750             


Lys Leu  Thr Tyr Lys Ala Arg  Pro Cys Lys Lys Asp  Glu Phe Ala 
    3755                 3760                 3765             


Cys Ser  Asn Lys Lys Cys Ile  Pro Met Asp Leu Gln  Cys Asp Arg 
    3770                 3775                 3780             


Leu Asp  Asp Cys Gly Asp Gly  Ser Asp Glu Gln Gly  Cys Arg Ile 
    3785                 3790                 3795             


Ala Pro  Thr Glu Tyr Thr Cys  Glu Asp Asn Val Asn  Pro Cys Gly 
    3800                 3805                 3810             


Asp Asp  Ala Tyr Cys Asn Gln  Ile Lys Thr Ser Val  Phe Cys Arg 
    3815                 3820                 3825             


Cys Lys  Pro Gly Phe Gln Arg  Asn Met Lys Asn Arg  Gln Cys Glu 
    3830                 3835                 3840             


Asp Leu  Asn Glu Cys Leu Val  Phe Gly Thr Cys Ser  His Gln Cys 
    3845                 3850                 3855             


Ile Asn  Val Glu Gly Ser Tyr  Lys Cys Val Cys Asp  Gln Asn Phe 
    3860                 3865                 3870             


Gln Glu  Arg Asn Asn Thr Cys  Ile Ala Glu Gly Ser  Glu Asp Gln 
    3875                 3880                 3885             


Val Leu  Tyr Ile Ala Asn Asp  Thr Asp Ile Leu Gly  Phe Ile Tyr 
    3890                 3895                 3900             


Pro Phe  Asn Tyr Ser Gly Asp  His Gln Gln Ile Ser  His Ile Glu 
    3905                 3910                 3915             


His Asn  Ser Arg Ile Thr Gly  Met Asp Val Tyr Tyr  Gln Arg Asp 
    3920                 3925                 3930             


Met Ile  Ile Trp Ser Thr Gln  Phe Asn Pro Gly Gly  Ile Phe Tyr 
    3935                 3940                 3945             


Lys Arg  Ile His Gly Arg Glu  Lys Arg Gln Ala Asn  Ser Gly Leu 
    3950                 3955                 3960             


Ile Cys  Pro Glu Phe Lys Arg  Pro Arg Asp Ile Ala  Val Asp Trp 
    3965                 3970                 3975             


Val Ala  Gly Asn Ile Tyr Trp  Thr Asp His Ser Arg  Met His Trp 
    3980                 3985                 3990             


Phe Ser  Tyr Tyr Thr Thr His  Trp Thr Ser Leu Arg  Tyr Ser Ile 
    3995                 4000                 4005             


Asn Val  Gly Gln Leu Asn Gly  Pro Asn Cys Thr Arg  Leu Leu Thr 
    4010                 4015                 4020             


Asn Met  Ala Gly Glu Pro Tyr  Ala Ile Ala Val Asn  Pro Lys Arg 
    4025                 4030                 4035             


Gly Met  Met Tyr Trp Thr Val  Val Gly Asp His Ser  His Ile Glu 
    4040                 4045                 4050             


Glu Ala  Ala Met Asp Gly Thr  Leu Arg Arg Ile Leu  Val Gln Lys 
    4055                 4060                 4065             


Asn Leu  Gln Arg Pro Thr Gly  Leu Ala Val Asp Tyr  Phe Ser Glu 
    4070                 4075                 4080             


Arg Ile  Tyr Trp Ala Asp Phe  Glu Leu Ser Ile Ile  Gly Ser Val 
    4085                 4090                 4095             


Leu Tyr  Asp Gly Ser Asn Ser  Val Val Ser Val Ser  Ser Lys Gln 
    4100                 4105                 4110             


Gly Leu  Leu His Pro His Arg  Ile Asp Ile Phe Glu  Asp Tyr Ile 
    4115                 4120                 4125             


Tyr Gly  Ala Gly Pro Lys Asn  Gly Val Phe Arg Val  Gln Lys Phe 
    4130                 4135                 4140             


Gly His  Gly Ser Val Glu Tyr  Leu Ala Leu Asn Ile  Asp Lys Thr 
    4145                 4150                 4155             


Lys Gly  Val Leu Ile Ser His  Arg Tyr Lys Gln Leu  Asp Leu Pro 
    4160                 4165                 4170             


Asn Pro  Cys Leu Asp Leu Ala  Cys Glu Phe Leu Cys  Leu Leu Asn 
    4175                 4180                 4185             


Pro Ser  Gly Ala Thr Cys Val  Cys Pro Glu Gly Lys  Tyr Leu Ile 
    4190                 4195                 4200             


Asn Gly  Thr Cys Asn Asp Asp  Ser Leu Leu Asp Asp  Ser Cys Lys 
    4205                 4210                 4215             


Leu Thr  Cys Glu Asn Gly Gly  Arg Cys Ile Leu Asn  Glu Lys Gly 
    4220                 4225                 4230             


Asp Leu  Arg Cys His Cys Trp  Pro Ser Tyr Ser Gly  Glu Arg Cys 
    4235                 4240                 4245             


Glu Val  Asn His Cys Ser Asn  Tyr Cys Gln Asn Gly  Gly Thr Cys 
    4250                 4255                 4260             


Val Pro  Ser Val Leu Gly Arg  Pro Thr Cys Ser Cys  Ala Leu Gly 
    4265                 4270                 4275             


Phe Thr  Gly Pro Asn Cys Gly  Lys Thr Val Cys Glu  Asp Phe Cys 
    4280                 4285                 4290             


Gln Asn  Gly Gly Thr Cys Ile  Val Thr Ala Gly Asn  Gln Pro Tyr 
    4295                 4300                 4305             


Cys His  Cys Gln Pro Glu Tyr  Thr Gly Asp Arg Cys  Gln Tyr Tyr 
    4310                 4315                 4320             


Val Cys  His His Tyr Cys Val  Asn Ser Glu Ser Cys  Thr Ile Gly 
    4325                 4330                 4335             


Asp Asp  Gly Ser Val Glu Cys  Val Cys Pro Thr Arg  Tyr Glu Gly 
    4340                 4345                 4350             


Pro Lys  Cys Glu Val Asp Lys  Cys Val Arg Cys His  Gly Gly His 
    4355                 4360                 4365             


Cys Ile  Ile Asn Lys Asp Ser  Glu Asp Ile Phe Cys  Asn Cys Thr 
    4370                 4375                 4380             


Asn Gly  Lys Ile Ala Ser Ser  Cys Gln Leu Cys Asp  Gly Tyr Cys 
    4385                 4390                 4395             


Tyr Asn  Gly Gly Thr Cys Gln  Leu Asp Pro Glu Thr  Asn Val Pro 
    4400                 4405                 4410             


Val Cys  Leu Cys Ser Thr Asn  Trp Ser Gly Thr Gln  Cys Glu Arg 
    4415                 4420                 4425             


Pro Ala  Pro Lys Ser Ser Lys  Ser Asp His Ile Ser  Thr Arg Ser 
    4430                 4435                 4440             


Ile Ala  Ile Ile Val Pro Leu  Val Leu Leu Val Thr  Leu Ile Thr 
    4445                 4450                 4455             


Thr Leu  Val Ile Gly Leu Val  Leu Cys Lys Arg Lys  Arg Arg Thr 
    4460                 4465                 4470             


Lys Thr  Ile Arg Arg Gln Pro  Ile Ile Asn Gly Gly  Ile Asn Val 
    4475                 4480                 4485             


Glu Ile  Gly Asn Pro Ser Tyr  Asn Met Tyr Glu Val  Asp His Asp 
    4490                 4495                 4500             


His Asn  Asp Gly Gly Leu Leu  Asp Pro Gly Phe Met  Ile Asp Pro 
    4505                 4510                 4515             


Thr Lys  Ala Arg Tyr Ile Gly  Gly Gly Pro Ser Ala  Phe Lys Leu 
    4520                 4525                 4530             


Pro His  Thr Ala Pro Pro Ile  Tyr Leu Asn Ser Asp  Leu Lys Gly 
    4535                 4540                 4545             


Pro Leu  Thr Ala Gly Pro Thr  Asn Tyr Ser Asn Pro  Val Tyr Ala 
    4550                 4555                 4560             


Lys Leu  Tyr Met Asp Gly Gln  Asn Cys Arg Asn Ser  Leu Gly Ser 
    4565                 4570                 4575             


Val Asp  Glu Arg Lys Glu Leu  Leu Pro Lys Lys Ile  Glu Ile Gly 
    4580                 4585                 4590             


Ile Arg  Glu Thr Val Ala 
    4595                 


<210>  27
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Arg Val Leu Gly Gly Arg Cys Gly Ala Pro Leu Ala Cys Leu Leu 
1               5                   10                  15      


Leu Val Leu Pro Val Ser Glu Ala Asn Leu Leu Ser Lys Gln Gln Ala 
            20                  25                  30          


Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu 
        35                  40                  45              


Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn 
    50                  55                  60                  


Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr 
65                  70                  75                  80  


Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu 
                85                  90                  95      


Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg Ser 
            100                 105                 110         


Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro Cys Asn Glu 
        115                 120                 125             


Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala Ser Phe Thr Cys Thr 
    130                 135                 140                 


Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys Glu Phe Asp Ile Asn Glu 
145                 150                 155                 160 


Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp 
                165                 170                 175     


Asn Thr Pro Gly Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met 
            180                 185                 190         


Leu Ser Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys 
        195                 200                 205             


Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe 
    210                 215                 220                 


Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys Ser 
225                 230                 235                 240 


Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys Ala Gln Leu Cys 
                245                 250                 255     


Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr Cys Asp Gly Lys Lys Gly 
            260                 265                 270         


Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys Glu Val Val Ser Val Cys 
        275                 280                 285             


Leu Pro Leu Asn Leu Asp Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu 
    290                 295                 300                 


Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile 
305                 310                 315                 320 


Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly 
                325                 330                 335     


Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile 
            340                 345                 350         


Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu His Thr 
        355                 360                 365             


Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn Gly Leu Trp Asn 
    370                 375                 380                 


Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser Ile Lys Ile Ala 
385                 390                 395                 400 


Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro Leu Phe Lys Pro 
                405                 410                 415     


Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg 
            420                 425                 430         


Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly 
        435                 440                 445             


Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys 
    450                 455                 460                 


Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu 
465                 470                 475                 480 


Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp 
                485                 490                 495     


Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu 
            500                 505                 510         


Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser 
        515                 520                 525             


Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser 
    530                 535                 540                 


Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr 
545                 550                 555                 560 


Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu 
                565                 570                 575     


Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile 
            580                 585                 590         


Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp 
        595                 600                 605             


Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp 
    610                 615                 620                 


Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met 
625                 630                 635                 640 


Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser 
                645                 650                 655     


Lys His Asn Asp Ile Arg Ala His Ser Cys Pro Ser Val Trp Lys Lys 
            660                 665                 670         


Thr Lys Asn Ser 
        675     


<210>  28
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 
            20                  25                  30          


Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 
        35                  40                  45              


Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 
    50                  55                  60                  


Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 
65                  70                  75                  80  


Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 
                85                  90                  95      


Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 
            100                 105                 110         


Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 
        115                 120                 125             


Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 
    130                 135                 140                 


Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 
145                 150                 155                 160 


Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 
                165                 170                 175     


Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 
        195                 200                 205             


Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 
    210                 215                 220                 


Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 
225                 230                 235                 240 


Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 
                245                 250                 255     


Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 
            260                 265                 270         


Asp Met Asp Thr Cys Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Val 
        275                 280                 285             


Ala Lys Ser Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr 
    290                 295                 300                 


Pro Val Ile Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val 
305                 310                 315                 320 


Ala Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe 
                325                 330                 335     


Ala Gly Gly His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala 
            340                 345                 350         


Gly Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr 
        355                 360                 365             


Ser Ser Gly Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val 
    370                 375                 380                 


Glu Glu Leu Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val 
385                 390                 395                 400 


Met Lys Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu 
                405                 410                 415     


Tyr His Leu Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp 
            420                 425                 430         


Leu Val Gln Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp 
        435                 440                 445             


Asn Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val 
    450                 455                 460                 


Asn Thr Arg Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr 
465                 470                 475                 480 


Pro Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro 
                485                 490                 495     


Leu Asp Val Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His 
            500                 505                 510         


Ile Arg Pro Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro 
        515                 520                 525             


Asp Leu Arg Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser 
    530                 535                 540                 


Thr Lys Lys Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr 
545                 550                 555                 560 


Ala Leu Ala Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val 
                565                 570                 575     


Val Thr Val Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly 
            580                 585                 590         


Thr Arg Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu 
        595                 600                 605             


Ala Val Leu Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly 
    610                 615                 620                 


Gly Leu Pro Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr 
625                 630                 635                 640 


Arg Gly Cys Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp 
                645                 650                 655     


Glu Ala Ala Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro 
            660                 665                 670         


Val Glu Pro Ala Ala Ala 
        675             


<210>  29
<211>  1013
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Leu Gly Thr Leu Ser Pro Arg Met Leu Val Trp Leu Val Ala 
1               5                   10                  15      


Ser Gly Ile Val Phe Tyr Gly Glu Leu Trp Val Cys Ala Gly Leu Asp 
            20                  25                  30          


Tyr Asp Tyr Thr Phe Asp Gly Asn Glu Glu Asp Lys Thr Glu Thr Ile 
        35                  40                  45              


Asp Tyr Lys Asp Pro Cys Lys Ala Ala Val Phe Trp Gly Asp Ile Ala 
    50                  55                  60                  


Leu Asp Asp Glu Asp Leu Asn Ile Phe Gln Ile Asp Arg Thr Ile Asp 
65                  70                  75                  80  


Leu Thr Gln Asn Pro Phe Gly Asn Leu Gly His Thr Thr Gly Gly Leu 
                85                  90                  95      


Gly Asp His Ala Met Ser Lys Lys Arg Gly Ala Leu Tyr Gln Leu Ile 
            100                 105                 110         


Asp Arg Ile Arg Arg Ile Gly Phe Gly Leu Glu Gln Asn Asn Thr Val 
        115                 120                 125             


Lys Gly Lys Val Pro Leu Gln Phe Ser Gly Gln Asn Glu Lys Asn Arg 
    130                 135                 140                 


Val Pro Arg Ala Ala Thr Ser Arg Thr Glu Arg Ile Trp Pro Gly Gly 
145                 150                 155                 160 


Val Ile Pro Tyr Val Ile Gly Gly Asn Phe Thr Gly Ser Gln Arg Ala 
                165                 170                 175     


Met Phe Lys Gln Ala Met Arg His Trp Glu Lys His Thr Cys Val Thr 
            180                 185                 190         


Phe Ile Glu Arg Ser Asp Glu Glu Ser Tyr Ile Val Phe Thr Tyr Arg 
        195                 200                 205             


Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg Gly Asn Gly Pro Gln 
    210                 215                 220                 


Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe Gly Ile Val Val His 
225                 230                 235                 240 


Glu Leu Gly His Val Ile Gly Phe Trp His Glu His Thr Arg Pro Asp 
                245                 250                 255     


Arg Asp Asn His Val Thr Ile Ile Arg Glu Asn Ile Gln Pro Gly Gln 
            260                 265                 270         


Glu Tyr Asn Phe Leu Lys Met Glu Pro Gly Glu Val Asn Ser Leu Gly 
        275                 280                 285             


Glu Arg Tyr Asp Phe Asp Ser Ile Met His Tyr Ala Arg Asn Thr Phe 
    290                 295                 300                 


Ser Arg Gly Met Phe Leu Asp Thr Ile Leu Pro Ser Arg Asp Asp Asn 
305                 310                 315                 320 


Gly Ile Arg Pro Ala Ile Gly Gln Arg Thr Arg Leu Ser Lys Gly Asp 
                325                 330                 335     


Ile Ala Gln Ala Arg Lys Leu Tyr Arg Cys Pro Ala Cys Gly Glu Thr 
            340                 345                 350         


Leu Gln Glu Ser Asn Gly Asn Leu Ser Ser Pro Gly Phe Pro Asn Gly 
        355                 360                 365             


Tyr Pro Ser Tyr Thr His Cys Ile Trp Arg Val Ser Val Thr Pro Gly 
    370                 375                 380                 


Glu Lys Ile Val Leu Asn Phe Thr Thr Met Asp Leu Tyr Lys Ser Ser 
385                 390                 395                 400 


Leu Cys Trp Tyr Asp Tyr Ile Glu Val Arg Asp Gly Tyr Trp Arg Lys 
                405                 410                 415     


Ser Pro Leu Leu Gly Arg Phe Cys Gly Asp Lys Leu Pro Glu Val Leu 
            420                 425                 430         


Thr Ser Thr Asp Ser Arg Met Trp Ile Glu Phe Arg Ser Ser Ser Asn 
        435                 440                 445             


Trp Val Gly Lys Gly Phe Ala Ala Val Tyr Glu Ala Ile Cys Gly Gly 
    450                 455                 460                 


Glu Ile Arg Lys Asn Glu Gly Gln Ile Gln Ser Pro Asn Tyr Pro Asp 
465                 470                 475                 480 


Asp Tyr Arg Pro Met Lys Glu Cys Val Trp Lys Ile Thr Val Ser Glu 
                485                 490                 495     


Ser Tyr His Val Gly Leu Thr Phe Gln Ser Phe Glu Ile Glu Arg His 
            500                 505                 510         


Asp Asn Cys Ala Tyr Asp Tyr Leu Glu Val Arg Asp Gly Thr Ser Glu 
        515                 520                 525             


Asn Ser Pro Leu Ile Gly Arg Phe Cys Gly Tyr Asp Lys Pro Glu Asp 
    530                 535                 540                 


Ile Arg Ser Thr Ser Asn Thr Leu Trp Met Lys Phe Val Ser Asp Gly 
545                 550                 555                 560 


Thr Val Asn Lys Ala Gly Phe Ala Ala Asn Phe Phe Lys Glu Glu Asp 
                565                 570                 575     


Glu Cys Ala Lys Pro Asp Arg Gly Gly Cys Glu Gln Arg Cys Leu Asn 
            580                 585                 590         


Thr Leu Gly Ser Tyr Gln Cys Ala Cys Glu Pro Gly Tyr Glu Leu Gly 
        595                 600                 605             


Pro Asp Arg Arg Ser Cys Glu Ala Ala Cys Gly Gly Leu Leu Thr Lys 
    610                 615                 620                 


Leu Asn Gly Thr Ile Thr Thr Pro Gly Trp Pro Lys Glu Tyr Pro Pro 
625                 630                 635                 640 


Asn Lys Asn Cys Val Trp Gln Val Val Ala Pro Thr Gln Tyr Arg Ile 
                645                 650                 655     


Ser Val Lys Phe Glu Phe Phe Glu Leu Glu Gly Asn Glu Val Cys Lys 
            660                 665                 670         


Tyr Asp Tyr Val Glu Ile Trp Ser Gly Leu Ser Ser Glu Ser Lys Leu 
        675                 680                 685             


His Gly Lys Phe Cys Gly Ala Glu Val Pro Glu Val Ile Thr Ser Gln 
    690                 695                 700                 


Phe Asn Asn Met Arg Ile Glu Phe Lys Ser Asp Asn Thr Val Ser Lys 
705                 710                 715                 720 


Lys Gly Phe Lys Ala His Phe Phe Ser Asp Lys Asp Glu Cys Ser Lys 
                725                 730                 735     


Asp Asn Gly Gly Cys Gln His Glu Cys Val Asn Thr Met Gly Ser Tyr 
            740                 745                 750         


Met Cys Gln Cys Arg Asn Gly Phe Val Leu His Asp Asn Lys His Asp 
        755                 760                 765             


Cys Lys Glu Ala Glu Cys Glu Gln Lys Ile His Ser Pro Ser Gly Leu 
    770                 775                 780                 


Ile Thr Ser Pro Asn Trp Pro Asp Lys Tyr Pro Ser Arg Lys Glu Cys 
785                 790                 795                 800 


Thr Trp Glu Ile Ser Ala Thr Pro Gly His Arg Ile Lys Leu Ala Phe 
                805                 810                 815     


Ser Glu Phe Glu Ile Glu Gln His Gln Glu Cys Ala Tyr Asp His Leu 
            820                 825                 830         


Glu Val Phe Asp Gly Glu Thr Glu Lys Ser Pro Ile Leu Gly Arg Leu 
        835                 840                 845             


Cys Gly Asn Lys Ile Pro Asp Pro Leu Val Ala Thr Gly Asn Lys Met 
    850                 855                 860                 


Phe Val Arg Phe Val Ser Asp Ala Ser Val Gln Arg Lys Gly Phe Gln 
865                 870                 875                 880 


Ala Thr His Ser Thr Glu Cys Gly Gly Arg Leu Lys Ala Glu Ser Lys 
                885                 890                 895     


Pro Arg Asp Leu Tyr Ser His Ala Gln Phe Gly Asp Asn Asn Tyr Pro 
            900                 905                 910         


Gly Gln Val Asp Cys Glu Trp Leu Leu Val Ser Glu Arg Gly Ser Arg 
        915                 920                 925             


Leu Glu Leu Ser Phe Gln Thr Phe Glu Val Glu Glu Glu Ala Asp Cys 
    930                 935                 940                 


Gly Tyr Asp Tyr Val Glu Leu Phe Asp Gly Leu Asp Ser Thr Ala Val 
945                 950                 955                 960 


Gly Leu Gly Arg Phe Cys Gly Ser Gly Pro Pro Glu Glu Ile Tyr Ser 
                965                 970                 975     


Ile Gly Asp Ser Val Leu Ile His Phe His Thr Asp Asp Thr Ile Asn 
            980                 985                 990         


Lys Lys Gly Phe His Ile Arg Tyr  Lys Ser Ile Arg Tyr  Pro Asp Thr 
        995                 1000                 1005             


Thr His  Thr Lys Lys 
    1010             


<210>  30
<211>  1247
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Ala Ser Ser Ser Arg Ile Arg Ala Ala Trp Thr Arg Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Ala Gly Pro Val Gly Cys Leu Ser Arg Gln 
            20                  25                  30          


Glu Leu Phe Pro Phe Gly Pro Gly Gln Gly Asp Leu Glu Leu Glu Asp 
        35                  40                  45              


Gly Asp Asp Phe Val Ser Pro Ala Leu Glu Leu Ser Gly Ala Leu Arg 
    50                  55                  60                  


Phe Tyr Asp Arg Ser Asp Ile Asp Ala Val Tyr Val Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Ile Ala Thr Ser Glu Pro Pro Ala Lys Glu Ser His Pro Gly Leu 
                85                  90                  95      


Phe Pro Pro Thr Phe Gly Ala Val Ala Pro Phe Leu Ala Asp Leu Asp 
            100                 105                 110         


Thr Thr Asp Gly Leu Gly Lys Val Tyr Tyr Arg Glu Asp Leu Ser Pro 
        115                 120                 125             


Ser Ile Thr Gln Arg Ala Ala Glu Cys Val His Arg Gly Phe Pro Glu 
    130                 135                 140                 


Ile Ser Phe Gln Pro Ser Ser Ala Val Val Val Thr Trp Glu Ser Val 
145                 150                 155                 160 


Ala Pro Tyr Gln Gly Pro Ser Arg Asp Pro Asp Gln Lys Gly Lys Arg 
                165                 170                 175     


Asn Thr Phe Gln Ala Val Leu Ala Ser Ser Asp Ser Ser Ser Tyr Ala 
            180                 185                 190         


Ile Phe Leu Tyr Pro Glu Asp Gly Leu Gln Phe His Thr Thr Phe Ser 
        195                 200                 205             


Lys Lys Glu Asn Asn Gln Val Pro Ala Val Val Ala Phe Ser Gln Gly 
    210                 215                 220                 


Ser Val Gly Phe Leu Trp Lys Ser Asn Gly Ala Tyr Asn Ile Phe Ala 
225                 230                 235                 240 


Asn Asp Arg Glu Ser Val Glu Asn Leu Ala Lys Ser Ser Asn Ser Gly 
                245                 250                 255     


Gln Gln Gly Val Trp Val Phe Glu Ile Gly Ser Pro Ala Thr Thr Asn 
            260                 265                 270         


Gly Val Val Pro Ala Asp Val Ile Leu Gly Thr Glu Asp Gly Ala Glu 
        275                 280                 285             


Tyr Asp Asp Glu Asp Glu Asp Tyr Asp Leu Ala Thr Thr Arg Leu Gly 
    290                 295                 300                 


Leu Glu Asp Val Gly Thr Thr Pro Phe Ser Tyr Lys Ala Leu Arg Arg 
305                 310                 315                 320 


Gly Gly Ala Asp Thr Tyr Ser Val Pro Ser Val Leu Ser Pro Arg Arg 
                325                 330                 335     


Ala Ala Thr Glu Arg Pro Leu Gly Pro Pro Thr Glu Arg Thr Arg Ser 
            340                 345                 350         


Phe Gln Leu Ala Val Glu Thr Phe His Gln Gln His Pro Gln Val Ile 
        355                 360                 365             


Asp Val Asp Glu Val Glu Glu Thr Gly Val Val Phe Ser Tyr Asn Thr 
    370                 375                 380                 


Asp Ser Arg Gln Thr Cys Ala Asn Asn Arg His Gln Cys Ser Val His 
385                 390                 395                 400 


Ala Glu Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys Ser Cys Val Ala 
                405                 410                 415     


Gly Tyr Thr Gly Asn Gly Arg Gln Cys Val Ala Glu Gly Ser Pro Gln 
            420                 425                 430         


Arg Val Asn Gly Lys Val Lys Gly Arg Ile Phe Val Gly Ser Ser Gln 
        435                 440                 445             


Val Pro Ile Val Phe Glu Asn Thr Asp Leu His Ser Tyr Val Val Met 
    450                 455                 460                 


Asn His Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile Pro Glu Thr Val 
465                 470                 475                 480 


Gly Tyr Ser Leu Leu Pro Leu Ala Pro Val Gly Gly Ile Ile Gly Trp 
                485                 490                 495     


Met Phe Ala Val Glu Gln Asp Gly Phe Lys Asn Gly Phe Ser Ile Thr 
            500                 505                 510         


Gly Gly Glu Phe Thr Arg Gln Ala Glu Val Thr Phe Val Gly His Pro 
        515                 520                 525             


Gly Asn Leu Val Ile Lys Gln Arg Phe Ser Gly Ile Asp Glu His Gly 
    530                 535                 540                 


His Leu Thr Ile Asp Thr Glu Leu Glu Gly Arg Val Pro Gln Ile Pro 
545                 550                 555                 560 


Phe Gly Ser Ser Val His Ile Glu Pro Tyr Thr Glu Leu Tyr His Tyr 
                565                 570                 575     


Ser Thr Ser Val Ile Thr Ser Ser Ser Thr Arg Glu Tyr Thr Val Thr 
            580                 585                 590         


Glu Pro Glu Arg Asp Gly Ala Ser Pro Ser Arg Ile Tyr Thr Tyr Gln 
        595                 600                 605             


Trp Arg Gln Thr Ile Thr Phe Gln Glu Cys Val His Asp Asp Ser Arg 
    610                 615                 620                 


Pro Ala Leu Pro Ser Thr Gln Gln Leu Ser Val Asp Ser Val Phe Val 
625                 630                 635                 640 


Leu Tyr Asn Gln Glu Glu Lys Ile Leu Arg Tyr Ala Leu Ser Asn Ser 
                645                 650                 655     


Ile Gly Pro Val Arg Glu Gly Ser Pro Asp Ala Leu Gln Asn Pro Cys 
            660                 665                 670         


Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala Ala Cys Arg Pro Gly 
        675                 680                 685             


Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile Gly Phe Arg Gly Asp 
    690                 695                 700                 


Gly Arg Thr Cys Tyr Asp Ile Asp Glu Cys Ser Glu Gln Pro Ser Val 
705                 710                 715                 720 


Cys Gly Ser His Thr Ile Cys Asn Asn His Pro Gly Thr Phe Arg Cys 
                725                 730                 735     


Glu Cys Val Glu Gly Tyr Gln Phe Ser Asp Glu Gly Thr Cys Val Ala 
            740                 745                 750         


Val Val Asp Gln Arg Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn 
        755                 760                 765             


Cys Asp Ile Pro Gln Arg Ala Gln Cys Ile Tyr Thr Gly Gly Ser Ser 
    770                 775                 780                 


Tyr Thr Cys Ser Cys Leu Pro Gly Phe Ser Gly Asp Gly Gln Ala Cys 
785                 790                 795                 800 


Gln Asp Val Asp Glu Cys Gln Pro Ser Arg Cys His Pro Asp Ala Phe 
                805                 810                 815     


Cys Tyr Asn Thr Pro Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr 
            820                 825                 830         


Gln Gly Asp Gly Phe Arg Cys Val Pro Gly Glu Val Glu Lys Thr Arg 
        835                 840                 845             


Cys Gln His Glu Arg Glu His Ile Leu Gly Ala Ala Gly Ala Thr Asp 
    850                 855                 860                 


Pro Gln Arg Pro Ile Pro Pro Gly Leu Phe Val Pro Glu Cys Asp Ala 
865                 870                 875                 880 


His Gly His Tyr Ala Pro Thr Gln Cys His Gly Ser Thr Gly Tyr Cys 
                885                 890                 895     


Trp Cys Val Asp Arg Asp Gly Arg Glu Val Glu Gly Thr Arg Thr Arg 
            900                 905                 910         


Pro Gly Met Thr Pro Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His 
        915                 920                 925             


Gln Gly Pro Ala Val Pro Thr Ala Val Ile Pro Leu Pro Pro Gly Thr 
    930                 935                 940                 


His Leu Leu Phe Ala Gln Thr Gly Lys Ile Glu Arg Leu Pro Leu Glu 
945                 950                 955                 960 


Gly Asn Thr Met Arg Lys Thr Glu Ala Lys Ala Phe Leu His Val Pro 
                965                 970                 975     


Ala Lys Val Ile Ile Gly Leu Ala Phe Asp Cys Val Asp Lys Met Val 
            980                 985                 990         


Tyr Trp Thr Asp Ile Thr Glu Pro  Ser Ile Gly Arg Ala  Ser Leu His 
        995                 1000                 1005             


Gly Gly  Glu Pro Thr Thr Ile  Ile Arg Gln Asp Leu  Gly Ser Pro 
    1010                 1015                 1020             


Glu Gly  Ile Ala Val Asp His  Leu Gly Arg Asn Ile  Phe Trp Thr 
    1025                 1030                 1035             


Asp Ser  Asn Leu Asp Arg Ile  Glu Val Ala Lys Leu  Asp Gly Thr 
    1040                 1045                 1050             


Gln Arg  Arg Val Leu Phe Glu  Thr Asp Leu Val Asn  Pro Arg Gly 
    1055                 1060                 1065             


Ile Val  Thr Asp Ser Val Arg  Gly Asn Leu Tyr Trp  Thr Asp Trp 
    1070                 1075                 1080             


Asn Arg  Asp Asn Pro Lys Ile  Glu Thr Ser Tyr Met  Asp Gly Thr 
    1085                 1090                 1095             


Asn Arg  Arg Ile Leu Val Gln  Asp Asp Leu Gly Leu  Pro Asn Gly 
    1100                 1105                 1110             


Leu Thr  Phe Asp Ala Phe Ser  Ser Gln Leu Cys Trp  Val Asp Ala 
    1115                 1120                 1125             


Gly Thr  Asn Arg Ala Glu Cys  Leu Asn Pro Ser Gln  Pro Ser Arg 
    1130                 1135                 1140             


Arg Lys  Ala Leu Glu Gly Leu  Gln Tyr Pro Phe Ala  Val Thr Ser 
    1145                 1150                 1155             


Tyr Gly  Lys Asn Leu Tyr Phe  Thr Asp Trp Lys Met  Asn Ser Val 
    1160                 1165                 1170             


Val Ala  Leu Asp Leu Ala Ile  Ser Lys Glu Thr Asp  Ala Phe Gln 
    1175                 1180                 1185             


Pro His  Lys Gln Thr Arg Leu  Tyr Gly Ile Thr Thr  Ala Leu Ser 
    1190                 1195                 1200             


Gln Cys  Pro Gln Gly His Asn  Tyr Cys Ser Val Asn  Asn Gly Gly 
    1205                 1210                 1215             


Cys Thr  His Leu Cys Leu Ala  Thr Pro Gly Ser Arg  Thr Cys Arg 
    1220                 1225                 1230             


Cys Pro  Asp Asn Thr Leu Gly  Val Asp Cys Ile Glu  Gln Lys 
    1235                 1240                 1245         


<210>  31
<211>  1015
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Arg Ala Thr Ala Leu Gly Ala Leu Val Ser Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Pro Arg Gly Ala Gly Gly Leu Gly Glu Arg Pro Asp Ala 
            20                  25                  30          


Thr Ala Asp Tyr Ser Glu Leu Asp Gly Glu Glu Gly Thr Glu Gln Gln 
        35                  40                  45              


Leu Glu His Tyr His Asp Pro Cys Lys Ala Ala Val Phe Trp Gly Asp 
    50                  55                  60                  


Ile Ala Leu Asp Glu Asp Asp Leu Lys Leu Phe His Ile Asp Lys Ala 
65                  70                  75                  80  


Arg Asp Trp Thr Lys Gln Thr Val Gly Ala Thr Gly His Ser Thr Gly 
                85                  90                  95      


Gly Leu Glu Glu Gln Ala Ser Glu Ser Ser Pro Asp Thr Thr Ala Met 
            100                 105                 110         


Asp Thr Gly Thr Lys Glu Ala Gly Lys Asp Gly Arg Glu Asn Thr Thr 
        115                 120                 125             


Leu Leu His Ser Pro Gly Thr Leu His Ala Ala Ala Lys Thr Phe Ser 
    130                 135                 140                 


Pro Arg Val Arg Arg Ala Thr Thr Ser Arg Thr Glu Arg Ile Trp Pro 
145                 150                 155                 160 


Gly Gly Val Ile Pro Tyr Val Ile Gly Gly Asn Phe Thr Gly Ser Gln 
                165                 170                 175     


Arg Ala Ile Phe Lys Gln Ala Met Arg His Trp Glu Lys His Thr Cys 
            180                 185                 190         


Val Thr Phe Ile Glu Arg Thr Asp Glu Glu Ser Phe Ile Val Phe Ser 
        195                 200                 205             


Tyr Arg Thr Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg Gly Gly Gly 
    210                 215                 220                 


Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe Gly Ile Val 
225                 230                 235                 240 


Ala His Glu Leu Gly His Val Val Gly Phe Trp His Glu His Thr Arg 
                245                 250                 255     


Pro Asp Arg Asp Gln His Val Thr Ile Ile Arg Glu Asn Ile Gln Pro 
            260                 265                 270         


Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Ala Gly Glu Val Ser Ser 
        275                 280                 285             


Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr Ala Arg Asn 
    290                 295                 300                 


Thr Phe Ser Arg Gly Val Phe Leu Asp Thr Ile Leu Pro Arg Gln Asp 
305                 310                 315                 320 


Asp Asn Gly Val Arg Pro Thr Ile Gly Gln Arg Val Arg Leu Ser Gln 
                325                 330                 335     


Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro Ala Cys Gly 
            340                 345                 350         


Glu Thr Leu Gln Asp Thr Thr Gly Asn Phe Ser Ala Pro Gly Phe Pro 
        355                 360                 365             


Asn Gly Tyr Pro Ser Tyr Ser His Cys Val Trp Arg Ile Ser Val Thr 
    370                 375                 380                 


Pro Gly Glu Lys Ile Val Leu Asn Phe Thr Ser Met Asp Leu Phe Lys 
385                 390                 395                 400 


Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp Gly Tyr Trp 
                405                 410                 415     


Arg Lys Ala Pro Leu Leu Gly Arg Phe Cys Gly Asp Lys Ile Pro Glu 
            420                 425                 430         


Pro Leu Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe Arg Ser Ser 
        435                 440                 445             


Ser Asn Ile Leu Gly Lys Gly Phe Phe Ala Ala Tyr Glu Ala Thr Cys 
    450                 455                 460                 


Gly Gly Asp Met Asn Lys Asp Ala Gly Gln Ile Gln Ser Pro Asn Tyr 
465                 470                 475                 480 


Pro Asp Asp Tyr Arg Pro Ser Lys Glu Cys Val Trp Arg Ile Thr Val 
                485                 490                 495     


Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ala Phe Glu Ile Glu 
            500                 505                 510         


Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg Asp Gly Pro 
        515                 520                 525             


Thr Glu Glu Ser Ala Leu Ile Gly His Phe Cys Gly Tyr Glu Lys Pro 
    530                 535                 540                 


Glu Asp Val Lys Ser Ser Ser Asn Arg Leu Trp Met Lys Phe Val Ser 
545                 550                 555                 560 


Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Ala Asn Phe Phe Lys Glu 
                565                 570                 575     


Val Asp Glu Cys Ser Trp Pro Asp His Gly Gly Cys Glu His Arg Cys 
            580                 585                 590         


Val Asn Thr Leu Gly Ser Tyr Lys Cys Ala Cys Asp Pro Gly Tyr Glu 
        595                 600                 605             


Leu Ala Ala Asp Lys Lys Met Cys Glu Val Ala Cys Gly Gly Phe Ile 
    610                 615                 620                 


Thr Lys Leu Asn Gly Thr Ile Thr Ser Pro Gly Trp Pro Lys Glu Tyr 
625                 630                 635                 640 


Pro Thr Asn Lys Asn Cys Val Trp Gln Val Val Ala Pro Ala Gln Tyr 
                645                 650                 655     


Arg Ile Ser Leu Gln Phe Glu Val Phe Glu Leu Glu Gly Asn Asp Val 
            660                 665                 670         


Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Ser Pro Asp Ala 
        675                 680                 685             


Lys Leu His Gly Arg Phe Cys Gly Ser Glu Thr Pro Glu Val Ile Thr 
    690                 695                 700                 


Ser Gln Ser Asn Asn Met Arg Val Glu Phe Lys Ser Asp Asn Thr Val 
705                 710                 715                 720 


Ser Lys Arg Gly Phe Arg Ala His Phe Phe Ser Asp Lys Asp Glu Cys 
                725                 730                 735     


Ala Lys Asp Asn Gly Gly Cys Gln His Glu Cys Val Asn Thr Phe Gly 
            740                 745                 750         


Ser Tyr Leu Cys Arg Cys Arg Asn Gly Tyr Trp Leu His Glu Asn Gly 
        755                 760                 765             


His Asp Cys Lys Glu Ala Gly Cys Ala His Lys Ile Ser Ser Val Glu 
    770                 775                 780                 


Gly Thr Leu Ala Ser Pro Asn Trp Pro Asp Lys Tyr Pro Ser Arg Arg 
785                 790                 795                 800 


Glu Cys Thr Trp Asn Ile Ser Ser Thr Ala Gly His Arg Val Lys Leu 
                805                 810                 815     


Thr Phe Asn Glu Phe Glu Ile Glu Gln His Gln Glu Cys Ala Tyr Asp 
            820                 825                 830         


His Leu Glu Met Tyr Asp Gly Pro Asp Ser Leu Ala Pro Ile Leu Gly 
        835                 840                 845             


Arg Phe Cys Gly Ser Lys Lys Pro Asp Pro Thr Val Ala Ser Gly Ser 
    850                 855                 860                 


Ser Met Phe Leu Arg Phe Tyr Ser Asp Ala Ser Val Gln Arg Lys Gly 
865                 870                 875                 880 


Phe Gln Ala Val His Ser Thr Glu Cys Gly Gly Arg Leu Lys Ala Glu 
                885                 890                 895     


Val Gln Thr Lys Glu Leu Tyr Ser His Ala Gln Phe Gly Asp Asn Asn 
            900                 905                 910         


Tyr Pro Ser Glu Ala Arg Cys Asp Trp Val Ile Val Ala Glu Asp Gly 
        915                 920                 925             


Tyr Gly Val Glu Leu Thr Phe Arg Thr Phe Glu Val Glu Glu Glu Ala 
    930                 935                 940                 


Asp Cys Gly Tyr Asp Tyr Met Glu Ala Tyr Asp Gly Tyr Asp Ser Ser 
945                 950                 955                 960 


Ala Pro Arg Leu Gly Arg Phe Cys Gly Ser Gly Pro Leu Glu Glu Ile 
                965                 970                 975     


Tyr Ser Ala Gly Asp Ser Leu Met Ile Arg Phe Arg Thr Asp Asp Thr 
            980                 985                 990         


Ile Asn Lys Lys Gly Phe His Ala  Arg Tyr Thr Ser Thr  Lys Phe Gln 
        995                 1000                 1005             


Asp Ala  Leu His Met Lys Lys  
    1010                 1015 


<210>  32
<211>  1207
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         


<210>  33
<211>  2912
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn 
        115                 120                 125             


Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys 
    130                 135                 140                 


Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala 
145                 150                 155                 160 


Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly 
                165                 170                 175     


Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Gly 
            180                 185                 190         


Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu 
        195                 200                 205             


Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met 
    210                 215                 220                 


Cys Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys 
225                 230                 235                 240 


Ala Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala 
                245                 250                 255     


Gln Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly 
            260                 265                 270         


Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln 
        275                 280                 285             


Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro 
    290                 295                 300                 


Ala Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp 
305                 310                 315                 320 


Glu Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn 
                325                 330                 335     


Thr Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser 
            340                 345                 350         


Thr Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser 
        355                 360                 365             


Gly Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr 
    370                 375                 380                 


Lys Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr 
385                 390                 395                 400 


Ile Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu 
                405                 410                 415     


Cys Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser 
            420                 425                 430         


Arg Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly 
        435                 440                 445             


Asn Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly 
    450                 455                 460                 


Asn Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly 
465                 470                 475                 480 


Gln Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp 
                485                 490                 495     


Ile Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro 
            500                 505                 510         


Thr Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp 
        515                 520                 525             


Ala Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys 
    530                 535                 540                 


Thr Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys 
545                 550                 555                 560 


His Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile 
                565                 570                 575     


Asp Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val 
            580                 585                 590         


Asn Thr Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu 
        595                 600                 605             


Thr Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr 
    610                 615                 620                 


Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys 
625                 630                 635                 640 


Cys Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys 
                645                 650                 655     


Thr Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His 
            660                 665                 670         


Cys Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu 
        675                 680                 685             


Ala Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser 
    690                 695                 700                 


Thr Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro 
705                 710                 715                 720 


Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly 
                725                 730                 735     


Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe 
            740                 745                 750         


His Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp 
        755                 760                 765             


Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys 
    770                 775                 780                 


Glu Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu 
785                 790                 795                 800 


Pro Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val 
                805                 810                 815     


Asn Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser 
            820                 825                 830         


Tyr Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu 
        835                 840                 845             


Thr Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly 
    850                 855                 860                 


Ala Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly 
865                 870                 875                 880 


Ser Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly 
                885                 890                 895     


Thr Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn 
            900                 905                 910         


Gly Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp 
        915                 920                 925             


Gly Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly 
    930                 935                 940                 


Leu Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu 
945                 950                 955                 960 


Val Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly 
                965                 970                 975     


Ser Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly 
            980                 985                 990         


Arg Val Cys Leu Asp Ile Arg Met  Glu Gln Cys Tyr Leu  Lys Trp Asp 
        995                 1000                 1005             


Glu Asp  Glu Cys Ile His Pro  Val Pro Gly Lys Phe  Arg Met Asp 
    1010                 1015                 1020             


Ala Cys  Cys Cys Ala Val Gly  Ala Ala Trp Gly Thr  Glu Cys Glu 
    1025                 1030                 1035             


Glu Cys  Pro Lys Pro Gly Thr  Lys Glu Tyr Glu Thr  Leu Cys Pro 
    1040                 1045                 1050             


Arg Gly  Ala Gly Phe Ala Asn  Arg Gly Asp Val Leu  Thr Gly Arg 
    1055                 1060                 1065             


Pro Phe  Tyr Lys Asp Ile Asn  Glu Cys Lys Ala Phe  Pro Gly Met 
    1070                 1075                 1080             


Cys Thr  Tyr Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1085                 1090                 1095             


Arg Cys  Asn Ser Gly Phe Ala  Leu Asp Met Glu Glu  Arg Asn Cys 
    1100                 1105                 1110             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Ser 
    1115                 1120                 1125             


Gly Ile  Cys Val Asn Thr Pro  Gly Ser Phe Glu Cys  Glu Cys Phe 
    1130                 1135                 1140             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1145                 1150                 1155             


Ile Asp  Glu Cys Glu Arg Asn  Pro Leu Leu Cys Arg  Gly Gly Thr 
    1160                 1165                 1170             


Cys Val  Asn Thr Glu Gly Ser  Phe Gln Cys Asp Cys  Pro Leu Gly 
    1175                 1180                 1185             


His Glu  Leu Ser Pro Ser Arg  Glu Asp Cys Val Asp  Ile Asn Glu 
    1190                 1195                 1200             


Cys Ser  Leu Ser Asp Asn Leu  Cys Arg Asn Gly Lys  Cys Val Asn 
    1205                 1210                 1215             


Met Ile  Gly Thr Tyr Gln Cys  Ser Cys Asn Pro Gly  Tyr Gln Ala 
    1220                 1225                 1230             


Thr Pro  Asp Arg Gln Gly Cys  Thr Asp Ile Asp Glu  Cys Met Ile 
    1235                 1240                 1245             


Met Asn  Gly Gly Cys Asp Thr  Gln Cys Thr Asn Ser  Glu Gly Ser 
    1250                 1255                 1260             


Tyr Glu  Cys Ser Cys Ser Glu  Gly Tyr Ala Leu Met  Pro Asp Gly 
    1265                 1270                 1275             


Arg Ser  Cys Ala Asp Ile Asp  Glu Cys Glu Asn Asn  Pro Asp Ile 
    1280                 1285                 1290             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1295                 1300                 1305             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Met Asp Met  Lys Thr Cys 
    1310                 1315                 1320             


Ile Asp  Val Asn Glu Cys Asp  Leu Asn Ser Asn Ile  Cys Met Phe 
    1325                 1330                 1335             


Gly Glu  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Gln 
    1340                 1345                 1350             


Leu Gly  Tyr Ser Val Lys Lys  Gly Thr Thr Gly Cys  Thr Asp Val 
    1355                 1360                 1365             


Asp Glu  Cys Glu Ile Gly Ala  His Asn Cys Asp Met  His Ala Ser 
    1370                 1375                 1380             


Cys Leu  Asn Ile Pro Gly Ser  Phe Lys Cys Ser Cys  Arg Glu Gly 
    1385                 1390                 1395             


Trp Ile  Gly Asn Gly Ile Lys  Cys Ile Asp Leu Asp  Glu Cys Ser 
    1400                 1405                 1410             


Asn Gly  Thr His Gln Cys Ser  Ile Asn Ala Gln Cys  Val Asn Thr 
    1415                 1420                 1425             


Pro Gly  Ser Tyr Arg Cys Ala  Cys Ser Glu Gly Phe  Thr Gly Asp 
    1430                 1435                 1440             


Gly Phe  Thr Cys Ser Asp Val  Asp Glu Cys Ala Glu  Asn Ile Asn 
    1445                 1450                 1455             


Leu Cys  Glu Asn Gly Gln Cys  Leu Asn Val Pro Gly  Ala Tyr Arg 
    1460                 1465                 1470             


Cys Glu  Cys Glu Met Gly Phe  Thr Pro Ala Ser Asp  Ser Arg Ser 
    1475                 1480                 1485             


Cys Gln  Asp Ile Asp Glu Cys  Ser Phe Gln Asn Ile  Cys Val Phe 
    1490                 1495                 1500             


Gly Thr  Cys Asn Asn Leu Pro  Gly Met Phe His Cys  Ile Cys Asp 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Leu Asp Arg  Thr Gly Gly Asn Cys  Thr Asp Ile 
    1520                 1525                 1530             


Asp Glu  Cys Ala Asp Pro Ile  Asn Cys Val Asn Gly  Leu Cys Val 
    1535                 1540                 1545             


Asn Thr  Pro Gly Arg Tyr Glu  Cys Asn Cys Pro Pro  Asp Phe Gln 
    1550                 1555                 1560             


Leu Asn  Pro Thr Gly Val Gly  Cys Val Asp Asn Arg  Val Gly Asn 
    1565                 1570                 1575             


Cys Tyr  Leu Lys Phe Gly Pro  Arg Gly Asp Gly Ser  Leu Ser Cys 
    1580                 1585                 1590             


Asn Thr  Glu Ile Gly Val Gly  Val Ser Arg Ser Ser  Cys Cys Cys 
    1595                 1600                 1605             


Ser Leu  Gly Lys Ala Trp Gly  Asn Pro Cys Glu Thr  Cys Pro Pro 
    1610                 1615                 1620             


Val Asn  Ser Thr Glu Tyr Tyr  Thr Leu Cys Pro Gly  Gly Glu Gly 
    1625                 1630                 1635             


Phe Arg  Pro Asn Pro Ile Thr  Ile Ile Leu Glu Asp  Ile Asp Glu 
    1640                 1645                 1650             


Cys Gln  Glu Leu Pro Gly Leu  Cys Gln Gly Gly Asn  Cys Ile Asn 
    1655                 1660                 1665             


Thr Phe  Gly Ser Phe Gln Cys  Glu Cys Pro Gln Gly  Tyr Tyr Leu 
    1670                 1675                 1680             


Ser Glu  Asp Thr Arg Ile Cys  Glu Asp Ile Asp Glu  Cys Phe Ala 
    1685                 1690                 1695             


His Pro  Gly Val Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Leu Gly 
    1700                 1705                 1710             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Glu Tyr Met Gln  Val Asn Gly 
    1715                 1720                 1725             


Gly His  Asn Cys Met Asp Met  Arg Lys Ser Phe Cys  Tyr Arg Ser 
    1730                 1735                 1740             


Tyr Asn  Gly Thr Thr Cys Glu  Asn Glu Leu Pro Phe  Asn Val Thr 
    1745                 1750                 1755             


Lys Arg  Met Cys Cys Cys Thr  Tyr Asn Val Gly Lys  Ala Trp Asn 
    1760                 1765                 1770             


Lys Pro  Cys Glu Pro Cys Pro  Thr Pro Gly Thr Ala  Asp Phe Lys 
    1775                 1780                 1785             


Thr Ile  Cys Gly Asn Ile Pro  Gly Phe Thr Phe Asp  Ile His Thr 
    1790                 1795                 1800             


Gly Lys  Ala Val Asp Ile Asp  Glu Cys Lys Glu Ile  Pro Gly Ile 
    1805                 1810                 1815             


Cys Ala  Asn Gly Val Cys Ile  Asn Gln Ile Gly Ser  Phe Arg Cys 
    1820                 1825                 1830             


Glu Cys  Pro Thr Gly Phe Ser  Tyr Asn Asp Leu Leu  Leu Val Cys 
    1835                 1840                 1845             


Glu Asp  Ile Asp Glu Cys Ser  Asn Gly Asp Asn Leu  Cys Gln Arg 
    1850                 1855                 1860             


Asn Ala  Asp Cys Ile Asn Ser  Pro Gly Ser Tyr Arg  Cys Glu Cys 
    1865                 1870                 1875             


Ala Ala  Gly Phe Lys Leu Ser  Pro Asn Gly Ala Cys  Val Asp Arg 
    1880                 1885                 1890             


Asn Glu  Cys Leu Glu Ile Pro  Asn Val Cys Ser His  Gly Leu Cys 
    1895                 1900                 1905             


Val Asp  Leu Gln Gly Ser Tyr  Gln Cys Ile Cys His  Asn Gly Phe 
    1910                 1915                 1920             


Lys Ala  Ser Gln Asp Gln Thr  Met Cys Met Asp Val  Asp Glu Cys 
    1925                 1930                 1935             


Glu Arg  His Pro Cys Gly Asn  Gly Thr Cys Lys Asn  Thr Val Gly 
    1940                 1945                 1950             


Ser Tyr  Asn Cys Leu Cys Tyr  Pro Gly Phe Glu Leu  Thr His Asn 
    1955                 1960                 1965             


Asn Asp  Cys Leu Asp Ile Asp  Glu Cys Ser Ser Phe  Phe Gly Gln 
    1970                 1975                 1980             


Val Cys  Arg Asn Gly Arg Cys  Phe Asn Glu Ile Gly  Ser Phe Lys 
    1985                 1990                 1995             


Cys Leu  Cys Asn Glu Gly Tyr  Glu Leu Thr Pro Asp  Gly Lys Asn 
    2000                 2005                 2010             


Cys Ile  Asp Thr Asn Glu Cys  Val Ala Leu Pro Gly  Ser Cys Ser 
    2015                 2020                 2025             


Pro Gly  Thr Cys Gln Asn Leu  Glu Gly Ser Phe Arg  Cys Ile Cys 
    2030                 2035                 2040             


Pro Pro  Gly Tyr Glu Val Lys  Ser Glu Asn Cys Ile  Asp Ile Asn 
    2045                 2050                 2055             


Glu Cys  Asp Glu Asp Pro Asn  Ile Cys Leu Phe Gly  Ser Cys Thr 
    2060                 2065                 2070             


Asn Thr  Pro Gly Gly Phe Gln  Cys Leu Cys Pro Pro  Gly Phe Val 
    2075                 2080                 2085             


Leu Ser  Asp Asn Gly Arg Arg  Cys Phe Asp Thr Arg  Gln Ser Phe 
    2090                 2095                 2100             


Cys Phe  Thr Asn Phe Glu Asn  Gly Lys Cys Ser Val  Pro Lys Ala 
    2105                 2110                 2115             


Phe Asn  Thr Thr Lys Ala Lys  Cys Cys Cys Ser Lys  Met Pro Gly 
    2120                 2125                 2130             


Glu Gly  Trp Gly Asp Pro Cys  Glu Leu Cys Pro Lys  Asp Asp Glu 
    2135                 2140                 2145             


Val Ala  Phe Gln Asp Leu Cys  Pro Tyr Gly His Gly  Thr Val Pro 
    2150                 2155                 2160             


Ser Leu  His Asp Thr Arg Glu  Asp Val Asn Glu Cys  Leu Glu Ser 
    2165                 2170                 2175             


Pro Gly  Ile Cys Ser Asn Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2180                 2185                 2190             


Phe Arg  Cys Glu Cys Pro Met  Gly Tyr Asn Leu Asp  Tyr Thr Gly 
    2195                 2200                 2205             


Val Arg  Cys Val Asp Thr Asp  Glu Cys Ser Ile Gly  Asn Pro Cys 
    2210                 2215                 2220             


Gly Asn  Gly Thr Cys Thr Asn  Val Ile Gly Ser Phe  Glu Cys Asn 
    2225                 2230                 2235             


Cys Asn  Glu Gly Phe Glu Pro  Gly Pro Met Met Asn  Cys Glu Asp 
    2240                 2245                 2250             


Ile Asn  Glu Cys Ala Gln Asn  Pro Leu Leu Cys Ala  Phe Arg Cys 
    2255                 2260                 2265             


Met Asn  Thr Phe Gly Ser Tyr  Glu Cys Thr Cys Pro  Ile Gly Tyr 
    2270                 2275                 2280             


Ala Leu  Arg Glu Asp Gln Lys  Met Cys Lys Asp Leu  Asp Glu Cys 
    2285                 2290                 2295             


Ala Glu  Gly Leu His Asp Cys  Glu Ser Arg Gly Met  Met Cys Lys 
    2300                 2305                 2310             


Asn Leu  Ile Gly Thr Phe Met  Cys Ile Cys Pro Pro  Gly Met Ala 
    2315                 2320                 2325             


Arg Arg  Pro Asp Gly Glu Gly  Cys Val Asp Glu Asn  Glu Cys Arg 
    2330                 2335                 2340             


Thr Lys  Pro Gly Ile Cys Glu  Asn Gly Arg Cys Val  Asn Ile Ile 
    2345                 2350                 2355             


Gly Ser  Tyr Arg Cys Glu Cys  Asn Glu Gly Phe Gln  Ser Ser Ser 
    2360                 2365                 2370             


Ser Gly  Thr Glu Cys Leu Asp  Asn Arg Gln Gly Leu  Cys Phe Ala 
    2375                 2380                 2385             


Glu Val  Leu Gln Thr Ile Cys  Gln Met Ala Ser Ser  Ser Arg Asn 
    2390                 2395                 2400             


Leu Val  Thr Lys Ser Glu Cys  Cys Cys Asp Gly Gly  Arg Gly Trp 
    2405                 2410                 2415             


Gly His  Gln Cys Glu Leu Cys  Pro Leu Pro Gly Thr  Ala Gln Tyr 
    2420                 2425                 2430             


Lys Lys  Ile Cys Pro His Gly  Pro Gly Tyr Thr Thr  Asp Gly Arg 
    2435                 2440                 2445             


Asp Ile  Asp Glu Cys Lys Val  Met Pro Asn Leu Cys  Thr Asn Gly 
    2450                 2455                 2460             


Gln Cys  Ile Asn Thr Met Gly  Ser Phe Arg Cys Phe  Cys Lys Val 
    2465                 2470                 2475             


Gly Tyr  Thr Thr Asp Ile Ser  Gly Thr Ser Cys Ile  Asp Leu Asp 
    2480                 2485                 2490             


Glu Cys  Ser Gln Ser Pro Lys  Pro Cys Asn Tyr Ile  Cys Lys Asn 
    2495                 2500                 2505             


Thr Glu  Gly Ser Tyr Gln Cys  Ser Cys Pro Arg Gly  Tyr Val Leu 
    2510                 2515                 2520             


Gln Glu  Asp Gly Lys Thr Cys  Lys Asp Leu Asp Glu  Cys Gln Thr 
    2525                 2530                 2535             


Lys Gln  His Asn Cys Gln Phe  Leu Cys Val Asn Thr  Leu Gly Gly 
    2540                 2545                 2550             


Phe Thr  Cys Lys Cys Pro Pro  Gly Phe Thr Gln His  His Thr Ala 
    2555                 2560                 2565             


Cys Ile  Asp Asn Asn Glu Cys  Gly Ser Gln Pro Ser  Leu Cys Gly 
    2570                 2575                 2580             


Ala Lys  Gly Ile Cys Gln Asn  Thr Pro Gly Ser Phe  Ser Cys Glu 
    2585                 2590                 2595             


Cys Gln  Arg Gly Phe Ser Leu  Asp Ala Thr Gly Leu  Asn Cys Glu 
    2600                 2605                 2610             


Asp Val  Asp Glu Cys Asp Gly  Asn His Arg Cys Gln  His Gly Cys 
    2615                 2620                 2625             


Gln Asn  Ile Leu Gly Gly Tyr  Arg Cys Gly Cys Pro  Gln Gly Tyr 
    2630                 2635                 2640             


Ile Gln  His Tyr Gln Trp Asn  Gln Cys Val Asp Glu  Asn Glu Cys 
    2645                 2650                 2655             


Ser Asn  Pro Asn Ala Cys Gly  Ser Ala Ser Cys Tyr  Asn Thr Leu 
    2660                 2665                 2670             


Gly Ser  Tyr Lys Cys Ala Cys  Pro Ser Gly Phe Ser  Phe Asp Gln 
    2675                 2680                 2685             


Phe Ser  Ser Ala Cys His Asp  Val Asn Glu Cys Ser  Ser Ser Lys 
    2690                 2695                 2700             


Asn Pro  Cys Asn Tyr Gly Cys  Ser Asn Thr Glu Gly  Gly Tyr Leu 
    2705                 2710                 2715             


Cys Gly  Cys Pro Pro Gly Tyr  Tyr Arg Val Gly Gln  Gly His Cys 
    2720                 2725                 2730             


Val Ser  Gly Met Gly Phe Asn  Lys Gly Gln Tyr Leu  Ser Leu Asp 
    2735                 2740                 2745             


Thr Glu  Val Asp Glu Glu Asn  Ala Leu Ser Pro Glu  Ala Cys Tyr 
    2750                 2755                 2760             


Glu Cys  Lys Ile Asn Gly Tyr  Ser Lys Lys Asp Ser  Arg Gln Lys 
    2765                 2770                 2775             


Arg Ser  Ile His Glu Pro Asp  Pro Thr Ala Val Glu  Gln Ile Ser 
    2780                 2785                 2790             


Leu Glu  Ser Val Asp Met Asp  Ser Pro Val Asn Met  Lys Phe Asn 
    2795                 2800                 2805             


Leu Ser  His Leu Gly Ser Lys  Glu His Ile Leu Glu  Leu Arg Pro 
    2810                 2815                 2820             


Ala Ile  Gln Pro Leu Asn Asn  His Ile Arg Tyr Val  Ile Ser Gln 
    2825                 2830                 2835             


Gly Asn  Asp Asp Ser Val Phe  Arg Ile His Gln Arg  Asn Gly Leu 
    2840                 2845                 2850             


Ser Tyr  Leu His Thr Ala Lys  Lys Lys Leu Met Pro  Gly Thr Tyr 
    2855                 2860                 2865             


Thr Leu  Glu Ile Thr Ser Ile  Pro Leu Tyr Lys Lys  Lys Glu Leu 
    2870                 2875                 2880             


Lys Lys  Leu Glu Glu Ser Asn  Glu Asp Asp Tyr Leu  Leu Gly Glu 
    2885                 2890                 2895             


Leu Gly  Glu Ala Leu Arg Met  Arg Leu Gln Ile Gln  Leu Tyr 
    2900                 2905                 2910         


<210>  34
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220                 


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255     


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270         


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285             


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300                 


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320 


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335     


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350         


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365             


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380                 


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400 


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415     


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430         


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445             


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460                 


Cys Ile Pro Thr Pro Gly Ser Cys Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480 


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495     


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510         


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525             


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540                 


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560 


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575     


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590         


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605             


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620                 


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640 


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655     


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670         


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685             


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700                 


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720 


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735     


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750         


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765             


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780                 


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800 


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815     


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830         


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845             


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860                 


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880 


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895     


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910         


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925             


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940                 


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960 


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975     


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990         


Cys Glu Glu Cys Pro Met Arg Asn  Thr Pro Glu Tyr Glu  Glu Leu Cys 
        995                 1000                 1005             


Pro Arg  Gly Pro Gly Phe Ala  Thr Lys Glu Ile Thr  Asn Gly Lys 
    1010                 1015                 1020             


Pro Phe  Phe Lys Asp Ile Asn  Glu Cys Lys Met Ile  Pro Ser Leu 
    1025                 1030                 1035             


Cys Thr  His Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1040                 1045                 1050             


Arg Cys  Asp Ser Gly Phe Ala  Leu Asp Ser Glu Glu  Arg Asn Cys 
    1055                 1060                 1065             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Arg 
    1070                 1075                 1080             


Gly Gln  Cys Val Asn Thr Pro  Gly Asp Phe Glu Cys  Lys Cys Asp 
    1085                 1090                 1095             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Gln Arg Asp  Pro Leu Leu Cys Arg  Gly Gly Val 
    1115                 1120                 1125             


Cys His  Asn Thr Glu Gly Ser  Tyr Arg Cys Glu Cys  Pro Pro Gly 
    1130                 1135                 1140             


His Gln  Leu Ser Pro Asn Ile  Ser Ala Cys Ile Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Glu  Leu Ser Ala His Leu  Cys Pro Asn Gly Arg  Cys Val Asn 
    1160                 1165                 1170             


Leu Ile  Gly Lys Tyr Gln Cys  Ala Cys Asn Pro Gly  Tyr His Ser 
    1175                 1180                 1185             


Thr Pro  Asp Arg Leu Phe Cys  Val Asp Ile Asp Glu  Cys Ser Ile 
    1190                 1195                 1200             


Met Asn  Gly Gly Cys Glu Thr  Phe Cys Thr Asn Ser  Glu Gly Ser 
    1205                 1210                 1215             


Tyr Glu  Cys Ser Cys Gln Pro  Gly Phe Ala Leu Met  Pro Asp Gln 
    1220                 1225                 1230             


Arg Ser  Cys Thr Asp Ile Asp  Glu Cys Glu Asp Asn  Pro Asn Ile 
    1235                 1240                 1245             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1250                 1255                 1260             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Glu Asp Met  Lys Thr Cys 
    1265                 1270                 1275             


Val Asp  Val Asn Glu Cys Asp  Leu Asn Pro Asn Ile  Cys Leu Ser 
    1280                 1285                 1290             


Gly Thr  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Asp 
    1295                 1300                 1305             


Met Gly  Tyr Ser Gly Lys Lys  Gly Lys Thr Gly Cys  Thr Asp Ile 
    1310                 1315                 1320             


Asn Glu  Cys Glu Ile Gly Ala  His Asn Cys Gly Lys  His Ala Val 
    1325                 1330                 1335             


Cys Thr  Asn Thr Ala Gly Ser  Phe Lys Cys Ser Cys  Ser Pro Gly 
    1340                 1345                 1350             


Trp Ile  Gly Asp Gly Ile Lys  Cys Thr Asp Leu Asp  Glu Cys Ser 
    1355                 1360                 1365             


Asn Gly  Thr His Met Cys Ser  Gln His Ala Asp Cys  Lys Asn Thr 
    1370                 1375                 1380             


Met Gly  Ser Tyr Arg Cys Leu  Cys Lys Glu Gly Tyr  Thr Gly Asp 
    1385                 1390                 1395             


Gly Phe  Thr Cys Thr Asp Leu  Asp Glu Cys Ser Glu  Asn Leu Asn 
    1400                 1405                 1410             


Leu Cys  Gly Asn Gly Gln Cys  Leu Asn Ala Pro Gly  Gly Tyr Arg 
    1415                 1420                 1425             


Cys Glu  Cys Asp Met Gly Phe  Val Pro Ser Ala Asp  Gly Lys Ala 
    1430                 1435                 1440             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Pro Asn Ile  Cys Val Phe 
    1445                 1450                 1455             


Gly Thr  Cys His Asn Leu Pro  Gly Leu Phe Arg Cys  Glu Cys Glu 
    1460                 1465                 1470             


Ile Gly  Tyr Glu Leu Asp Arg  Ser Gly Gly Asn Cys  Thr Asp Val 
    1475                 1480                 1485             


Asn Glu  Cys Leu Asp Pro Thr  Thr Cys Ile Ser Gly  Asn Cys Val 
    1490                 1495                 1500             


Asn Thr  Pro Gly Ser Tyr Ile  Cys Asp Cys Pro Pro  Asp Phe Glu 
    1505                 1510                 1515             


Leu Asn  Pro Thr Arg Val Gly  Cys Val Asp Thr Arg  Ser Gly Asn 
    1520                 1525                 1530             


Cys Tyr  Leu Asp Ile Arg Pro  Arg Gly Asp Asn Gly  Asp Thr Ala 
    1535                 1540                 1545             


Cys Ser  Asn Glu Ile Gly Val  Gly Val Ser Lys Ala  Ser Cys Cys 
    1550                 1555                 1560             


Cys Ser  Leu Gly Lys Ala Trp  Gly Thr Pro Cys Glu  Met Cys Pro 
    1565                 1570                 1575             


Ala Val  Asn Thr Ser Glu Tyr  Lys Ile Leu Cys Pro  Gly Gly Glu 
    1580                 1585                 1590             


Gly Phe  Arg Pro Asn Pro Ile  Thr Val Ile Leu Glu  Asp Ile Asp 
    1595                 1600                 1605             


Glu Cys  Gln Glu Leu Pro Gly  Leu Cys Gln Gly Gly  Lys Cys Ile 
    1610                 1615                 1620             


Asn Thr  Phe Gly Ser Phe Gln  Cys Arg Cys Pro Thr  Gly Tyr Tyr 
    1625                 1630                 1635             


Leu Asn  Glu Asp Thr Arg Val  Cys Asp Asp Val Asn  Glu Cys Glu 
    1640                 1645                 1650             


Thr Pro  Gly Ile Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Val Gly 
    1655                 1660                 1665             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Asp Tyr Met Gln  Val Asn Gly 
    1670                 1675                 1680             


Gly Asn  Asn Cys Met Asp Met  Arg Arg Ser Leu Cys  Tyr Arg Asn 
    1685                 1690                 1695             


Tyr Tyr  Ala Asp Asn Gln Thr  Cys Asp Gly Glu Leu  Leu Phe Asn 
    1700                 1705                 1710             


Met Thr  Lys Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Arg Ala 
    1715                 1720                 1725             


Trp Asn  Lys Pro Cys Glu Gln  Cys Pro Ile Pro Ser  Thr Asp Glu 
    1730                 1735                 1740             


Phe Ala  Thr Leu Cys Gly Ser  Gln Arg Pro Gly Phe  Val Ile Asp 
    1745                 1750                 1755             


Ile Tyr  Thr Gly Leu Pro Val  Asp Ile Asp Glu Cys  Arg Glu Ile 
    1760                 1765                 1770             


Pro Gly  Val Cys Glu Asn Gly  Val Cys Ile Asn Met  Val Gly Ser 
    1775                 1780                 1785             


Phe Arg  Cys Glu Cys Pro Val  Gly Phe Phe Tyr Asn  Asp Lys Leu 
    1790                 1795                 1800             


Leu Val  Cys Glu Asp Ile Asp  Glu Cys Gln Asn Gly  Pro Val Cys 
    1805                 1810                 1815             


Gln Arg  Asn Ala Glu Cys Ile  Asn Thr Ala Gly Ser  Tyr Arg Cys 
    1820                 1825                 1830             


Asp Cys  Lys Pro Gly Tyr Arg  Phe Thr Ser Thr Gly  Gln Cys Asn 
    1835                 1840                 1845             


Asp Arg  Asn Glu Cys Gln Glu  Ile Pro Asn Ile Cys  Ser His Gly 
    1850                 1855                 1860             


Gln Cys  Ile Asp Thr Val Gly  Ser Phe Tyr Cys Leu  Cys His Thr 
    1865                 1870                 1875             


Gly Phe  Lys Thr Asn Asp Asp  Gln Thr Met Cys Leu  Asp Ile Asn 
    1880                 1885                 1890             


Glu Cys  Glu Arg Asp Ala Cys  Gly Asn Gly Thr Cys  Arg Asn Thr 
    1895                 1900                 1905             


Ile Gly  Ser Phe Asn Cys Arg  Cys Asn His Gly Phe  Ile Leu Ser 
    1910                 1915                 1920             


His Asn  Asn Asp Cys Ile Asp  Val Asp Glu Cys Ala  Ser Gly Asn 
    1925                 1930                 1935             


Gly Asn  Leu Cys Arg Asn Gly  Gln Cys Ile Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Phe Gln  Cys Gln Cys Asn Glu  Gly Tyr Glu Val Ala  Pro Asp Gly 
    1955                 1960                 1965             


Arg Thr  Cys Val Asp Ile Asn  Glu Cys Leu Leu Glu  Pro Arg Lys 
    1970                 1975                 1980             


Cys Ala  Pro Gly Thr Cys Gln  Asn Leu Asp Gly Ser  Tyr Arg Cys 
    1985                 1990                 1995             


Ile Cys  Pro Pro Gly Tyr Ser  Leu Gln Asn Glu Lys  Cys Glu Asp 
    2000                 2005                 2010             


Ile Asp  Glu Cys Val Glu Glu  Pro Glu Ile Cys Ala  Leu Gly Thr 
    2015                 2020                 2025             


Cys Ser  Asn Thr Glu Gly Ser  Phe Lys Cys Leu Cys  Pro Glu Gly 
    2030                 2035                 2040             


Phe Ser  Leu Ser Ser Ser Gly  Arg Arg Cys Gln Asp  Leu Arg Met 
    2045                 2050                 2055             


Ser Tyr  Cys Tyr Ala Lys Phe  Glu Gly Gly Lys Cys  Ser Ser Pro 
    2060                 2065                 2070             


Lys Ser  Arg Asn His Ser Lys  Gln Glu Cys Cys Cys  Ala Leu Lys 
    2075                 2080                 2085             


Gly Glu  Gly Trp Gly Asp Pro  Cys Glu Leu Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Asp Glu  Ala Phe Arg Gln Ile  Cys Pro Tyr Gly Ser  Gly Ile Ile 
    2105                 2110                 2115             


Val Gly  Pro Asp Asp Ser Ala  Val Asp Met Asp Glu  Cys Lys Glu 
    2120                 2125                 2130             


Pro Asp  Val Cys Lys His Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2135                 2140                 2145             


Tyr Arg  Cys Glu Cys Pro Phe  Gly Tyr Ile Leu Ala  Gly Asn Glu 
    2150                 2155                 2160             


Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly Asn Pro  Cys Gly Asn 
    2165                 2170                 2175             


Gly Thr  Cys Lys Asn Val Ile  Gly Gly Phe Glu Cys  Thr Cys Glu 
    2180                 2185                 2190             


Glu Gly  Phe Glu Pro Gly Pro  Met Met Thr Cys Glu  Asp Ile Asn 
    2195                 2200                 2205             


Glu Cys  Ala Gln Asn Pro Leu  Leu Cys Ala Phe Arg  Cys Val Asn 
    2210                 2215                 2220             


Thr Tyr  Gly Ser Tyr Glu Cys  Lys Cys Pro Val Gly  Tyr Val Leu 
    2225                 2230                 2235             


Arg Glu  Asp Arg Arg Met Cys  Lys Asp Glu Asp Glu  Cys Glu Glu 
    2240                 2245                 2250             


Gly Lys  His Asp Cys Thr Glu  Lys Gln Met Glu Cys  Lys Asn Leu 
    2255                 2260                 2265             


Ile Gly  Thr Tyr Met Cys Ile  Cys Gly Pro Gly Tyr  Gln Arg Arg 
    2270                 2275                 2280             


Pro Asp  Gly Glu Gly Cys Val  Asp Glu Asn Glu Cys  Gln Thr Lys 
    2285                 2290                 2295             


Pro Gly  Ile Cys Glu Asn Gly  Arg Cys Leu Asn Thr  Arg Gly Ser 
    2300                 2305                 2310             


Tyr Thr  Cys Glu Cys Asn Asp  Gly Phe Thr Ala Ser  Pro Asn Gln 
    2315                 2320                 2325             


Asp Glu  Cys Leu Asp Asn Arg  Glu Gly Tyr Cys Phe  Thr Glu Val 
    2330                 2335                 2340             


Leu Gln  Asn Met Cys Gln Ile  Gly Ser Ser Asn Arg  Asn Pro Val 
    2345                 2350                 2355             


Thr Lys  Ser Glu Cys Cys Cys  Asp Gly Gly Arg Gly  Trp Gly Pro 
    2360                 2365                 2370             


His Cys  Glu Ile Cys Pro Phe  Gln Gly Thr Val Ala  Phe Lys Lys 
    2375                 2380                 2385             


Leu Cys  Pro His Gly Arg Gly  Phe Met Thr Asn Gly  Ala Asp Ile 
    2390                 2395                 2400             


Asp Glu  Cys Lys Val Ile His  Asp Val Cys Arg Asn  Gly Glu Cys 
    2405                 2410                 2415             


Val Asn  Asp Arg Gly Ser Tyr  His Cys Ile Cys Lys  Thr Gly Tyr 
    2420                 2425                 2430             


Thr Pro  Asp Ile Thr Gly Thr  Ser Cys Val Asp Leu  Asn Glu Cys 
    2435                 2440                 2445             


Asn Gln  Ala Pro Lys Pro Cys  Asn Phe Ile Cys Lys  Asn Thr Glu 
    2450                 2455                 2460             


Gly Ser  Tyr Gln Cys Ser Cys  Pro Lys Gly Tyr Ile  Leu Gln Glu 
    2465                 2470                 2475             


Asp Gly  Arg Ser Cys Lys Asp  Leu Asp Glu Cys Ala  Thr Lys Gln 
    2480                 2485                 2490             


His Asn  Cys Gln Phe Leu Cys  Val Asn Thr Ile Gly  Gly Phe Thr 
    2495                 2500                 2505             


Cys Lys  Cys Pro Pro Gly Phe  Thr Gln His His Thr  Ser Cys Ile 
    2510                 2515                 2520             


Asp Asn  Asn Glu Cys Thr Ser  Asp Ile Asn Leu Cys  Gly Ser Lys 
    2525                 2530                 2535             


Gly Ile  Cys Gln Asn Thr Pro  Gly Ser Phe Thr Cys  Glu Cys Gln 
    2540                 2545                 2550             


Arg Gly  Phe Ser Leu Asp Gln  Thr Gly Ser Ser Cys  Glu Asp Val 
    2555                 2560                 2565             


Asp Glu  Cys Glu Gly Asn His  Arg Cys Gln His Gly  Cys Gln Asn 
    2570                 2575                 2580             


Ile Ile  Gly Gly Tyr Arg Cys  Ser Cys Pro Gln Gly  Tyr Leu Gln 
    2585                 2590                 2595             


His Tyr  Gln Trp Asn Gln Cys  Val Asp Glu Asn Glu  Cys Leu Ser 
    2600                 2605                 2610             


Ala His  Ile Cys Gly Gly Ala  Ser Cys His Asn Thr  Leu Gly Ser 
    2615                 2620                 2625             


Tyr Lys  Cys Met Cys Pro Ala  Gly Phe Gln Tyr Glu  Gln Phe Ser 
    2630                 2635                 2640             


Gly Gly  Cys Gln Asp Ile Asn  Glu Cys Gly Ser Ala  Gln Ala Pro 
    2645                 2650                 2655             


Cys Ser  Tyr Gly Cys Ser Asn  Thr Glu Gly Gly Tyr  Leu Cys Gly 
    2660                 2665                 2670             


Cys Pro  Pro Gly Tyr Phe Arg  Ile Gly Gln Gly His  Cys Val Ser 
    2675                 2680                 2685             


Gly Met  Gly Met Gly Arg Gly  Asn Pro Glu Pro Pro  Val Ser Gly 
    2690                 2695                 2700             


Glu Met  Asp Asp Asn Ser Leu  Ser Pro Glu Ala Cys  Tyr Glu Cys 
    2705                 2710                 2715             


Lys Ile  Asn Gly Tyr Pro Lys  Arg Gly Arg Lys Arg  Arg Ser Thr 
    2720                 2725                 2730             


Asn Glu  Thr Asp Ala Ser Asn  Ile Glu Asp Gln Ser  Glu Thr Glu 
    2735                 2740                 2745             


Ala Asn  Val Ser Leu Ala Ser  Trp Asp Val Glu Lys  Thr Ala Ile 
    2750                 2755                 2760             


Phe Ala  Phe Asn Ile Ser His  Val Ser Asn Lys Val  Arg Ile Leu 
    2765                 2770                 2775             


Glu Leu  Leu Pro Ala Leu Thr  Thr Leu Thr Asn His  Asn Arg Tyr 
    2780                 2785                 2790             


Leu Ile  Glu Ser Gly Asn Glu  Asp Gly Phe Phe Lys  Ile Asn Gln 
    2795                 2800                 2805             


Lys Glu  Gly Ile Ser Tyr Leu  His Phe Thr Lys Lys  Lys Pro Val 
    2810                 2815                 2820             


Ala Gly  Thr Tyr Ser Leu Gln  Ile Ser Ser Thr Pro  Leu Tyr Lys 
    2825                 2830                 2835             


Lys Lys  Glu Leu Asn Gln Leu  Glu Asp Lys Tyr Asp  Lys Asp Tyr 
    2840                 2845                 2850             


Leu Ser  Gly Glu Leu Gly Asp  Asn Leu Lys Met Lys  Ile Gln Val 
    2855                 2860                 2865             


Leu Leu  His 
    2870     


<210>  35
<211>  2809
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Thr Leu Glu Gly Leu Tyr Leu Ala Arg Gly Pro Leu Ala Arg Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ser Ala Leu Leu Cys Met Ala Gly Gly Gln Gly Arg 
            20                  25                  30          


Trp Asp Gly Ala Leu Glu Ala Ala Gly Pro Gly Arg Val Arg Arg Arg 
        35                  40                  45              


Gly Ser Pro Gly Ile Leu Gln Gly Pro Asn Val Cys Gly Ser Arg Phe 
    50                  55                  60                  


His Ala Tyr Cys Cys Pro Gly Trp Arg Thr Phe Pro Gly Arg Ser Gln 
65                  70                  75                  80  


Cys Val Val Pro Ile Cys Arg Arg Ala Cys Gly Glu Gly Phe Cys Ser 
                85                  90                  95      


Gln Pro Asn Leu Cys Thr Cys Ala Asp Gly Thr Leu Ala Pro Ser Cys 
            100                 105                 110         


Gly Val Ser Arg Gly Ser Gly Cys Ser Val Ser Cys Met Asn Gly Gly 
        115                 120                 125             


Thr Cys Arg Gly Ala Ser Cys Leu Cys Gln Lys Gly Tyr Thr Gly Thr 
    130                 135                 140                 


Val Cys Gly Gln Pro Ile Cys Asp Arg Gly Cys His Asn Gly Gly Arg 
145                 150                 155                 160 


Cys Ile Gly Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Met Gly Pro 
                165                 170                 175     


Gln Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Gly Gln Val Gly 
            180                 185                 190         


Pro Glu Gly Cys Gln His Gln Leu Thr Gly Leu Val Cys Thr Lys Ala 
        195                 200                 205             


Leu Cys Cys Ala Thr Val Gly Arg Ala Trp Gly Leu Pro Cys Glu Leu 
    210                 215                 220                 


Cys Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile 
225                 230                 235                 240 


His Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Val Pro Gly 
                245                 250                 255     


Leu Cys Gln Gly Gly Ser Cys Val Asn Met Val Gly Ser Phe His Cys 
            260                 265                 270         


Arg Cys Pro Val Gly His Arg Leu Ser Asp Ser Ser Ala Ala Cys Glu 
        275                 280                 285             


Asp Tyr Arg Ala Gly Ala Cys Phe Ser Val Leu Phe Gly Gly Arg Cys 
    290                 295                 300                 


Ala Gly Asp Leu Ala Gly His Tyr Thr Arg Arg Gln Cys Cys Cys Asp 
305                 310                 315                 320 


Arg Gly Arg Cys Trp Ala Ala Gly Pro Val Pro Glu Leu Cys Pro Pro 
                325                 330                 335     


Arg Gly Ser Asn Glu Phe Gln Gln Leu Cys Ala Gln Arg Leu Pro Leu 
            340                 345                 350         


Leu Pro Gly His Pro Gly Leu Phe Pro Gly Leu Leu Gly Phe Gly Ser 
        355                 360                 365             


Asn Gly Met Gly Pro Pro Leu Gly Pro Ala Arg Leu Asn Pro His Gly 
    370                 375                 380                 


Ser Asp Ala Arg Gly Ile Pro Ser Leu Gly Pro Gly Asn Ser Asn Ile 
385                 390                 395                 400 


Gly Thr Ala Thr Leu Asn Gln Thr Ile Asp Ile Cys Arg His Phe Thr 
                405                 410                 415     


Asn Leu Cys Leu Asn Gly Arg Cys Leu Pro Thr Pro Ser Ser Tyr Arg 
            420                 425                 430         


Cys Glu Cys Asn Val Gly Tyr Thr Gln Asp Val Arg Gly Glu Cys Ile 
        435                 440                 445             


Asp Val Asp Glu Cys Thr Ser Ser Pro Cys His His Gly Asp Cys Val 
    450                 455                 460                 


Asn Ile Pro Gly Thr Tyr His Cys Arg Cys Tyr Pro Gly Phe Gln Ala 
465                 470                 475                 480 


Thr Pro Thr Arg Gln Ala Cys Val Asp Val Asp Glu Cys Ile Val Ser 
                485                 490                 495     


Gly Gly Leu Cys His Leu Gly Arg Cys Val Asn Thr Glu Gly Ser Phe 
            500                 505                 510         


Gln Cys Val Cys Asn Ala Gly Phe Glu Leu Ser Pro Asp Gly Lys Asn 
        515                 520                 525             


Cys Val Asp His Asn Glu Cys Ala Thr Ser Thr Met Cys Val Asn Gly 
    530                 535                 540                 


Val Cys Leu Asn Glu Asp Gly Ser Phe Ser Cys Leu Cys Lys Pro Gly 
545                 550                 555                 560 


Phe Leu Leu Ala Pro Gly Gly His Tyr Cys Met Asp Ile Asp Glu Cys 
                565                 570                 575     


Gln Thr Pro Gly Ile Cys Val Asn Gly His Cys Thr Asn Thr Glu Gly 
            580                 585                 590         


Ser Phe Arg Cys Gln Cys Leu Gly Gly Leu Ala Val Gly Thr Asp Gly 
        595                 600                 605             


Arg Val Cys Val Asp Thr His Val Arg Ser Thr Cys Tyr Gly Ala Ile 
    610                 615                 620                 


Glu Lys Gly Ser Cys Ala Arg Pro Phe Pro Gly Thr Val Thr Lys Ser 
625                 630                 635                 640 


Glu Cys Cys Cys Ala Asn Pro Asp His Gly Phe Gly Glu Pro Cys Gln 
                645                 650                 655     


Leu Cys Pro Ala Lys Asp Ser Ala Glu Phe Gln Ala Leu Cys Ser Ser 
            660                 665                 670         


Gly Leu Gly Ile Thr Thr Asp Gly Arg Asp Ile Asn Glu Cys Ala Leu 
        675                 680                 685             


Asp Pro Glu Val Cys Ala Asn Gly Val Cys Glu Asn Leu Arg Gly Ser 
    690                 695                 700                 


Tyr Arg Cys Val Cys Asn Leu Gly Tyr Glu Ala Gly Ala Ser Gly Lys 
705                 710                 715                 720 


Asp Cys Thr Asp Val Asp Glu Cys Ala Leu Asn Ser Leu Leu Cys Asp 
                725                 730                 735     


Asn Gly Trp Cys Gln Asn Ser Pro Gly Ser Tyr Ser Cys Ser Cys Pro 
            740                 745                 750         


Pro Gly Phe His Phe Trp Gln Asp Thr Glu Ile Cys Lys Asp Val Asp 
        755                 760                 765             


Glu Cys Leu Ser Ser Pro Cys Val Ser Gly Val Cys Arg Asn Leu Ala 
    770                 775                 780                 


Gly Ser Tyr Thr Cys Lys Cys Gly Pro Gly Ser Arg Leu Asp Pro Ser 
785                 790                 795                 800 


Gly Thr Phe Cys Leu Asp Ser Thr Lys Gly Thr Cys Trp Leu Lys Ile 
                805                 810                 815     


Gln Glu Ser Arg Cys Glu Val Asn Leu Gln Gly Ala Ser Leu Arg Ser 
            820                 825                 830         


Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly Ser Pro Cys Glu Arg 
        835                 840                 845             


Cys Glu Ile Asp Pro Ala Cys Ala Arg Gly Phe Ala Arg Met Thr Gly 
    850                 855                 860                 


Val Thr Cys Asp Asp Val Asn Glu Cys Glu Ser Phe Pro Gly Val Cys 
865                 870                 875                 880 


Pro Asn Gly Arg Cys Val Asn Thr Ala Gly Ser Phe Arg Cys Glu Cys 
                885                 890                 895     


Pro Glu Gly Leu Met Leu Asp Ala Ser Gly Arg Leu Cys Val Asp Val 
            900                 905                 910         


Arg Leu Glu Pro Cys Phe Leu Arg Trp Asp Glu Asp Glu Cys Gly Val 
        915                 920                 925             


Thr Leu Pro Gly Lys Tyr Arg Met Asp Val Cys Cys Cys Ser Ile Gly 
    930                 935                 940                 


Ala Val Trp Gly Val Glu Cys Glu Ala Cys Pro Asp Pro Glu Ser Leu 
945                 950                 955                 960 


Glu Phe Ala Ser Leu Cys Pro Arg Gly Leu Gly Phe Ala Ser Arg Asp 
                965                 970                 975     


Phe Leu Ser Gly Arg Pro Phe Tyr Lys Asp Val Asn Glu Cys Lys Val 
            980                 985                 990         


Phe Pro Gly Leu Cys Thr His Gly  Thr Cys Arg Asn Thr  Val Gly Ser 
        995                 1000                 1005             


Phe His  Cys Ala Cys Ala Gly  Gly Phe Ala Leu Asp  Ala Gln Glu 
    1010                 1015                 1020             


Arg Asn  Cys Thr Asp Ile Asp  Glu Cys Arg Ile Ser  Pro Asp Leu 
    1025                 1030                 1035             


Cys Gly  Gln Gly Thr Cys Val  Asn Thr Pro Gly Ser  Phe Glu Cys 
    1040                 1045                 1050             


Glu Cys  Phe Pro Gly Tyr Glu  Ser Gly Phe Met Leu  Met Lys Asn 
    1055                 1060                 1065             


Cys Met  Asp Val Asp Glu Cys  Ala Arg Asp Pro Leu  Leu Cys Arg 
    1070                 1075                 1080             


Gly Gly  Thr Cys Thr Asn Thr  Asp Gly Ser Tyr Lys  Cys Gln Cys 
    1085                 1090                 1095             


Pro Pro  Gly His Glu Leu Thr  Ala Lys Gly Thr Ala  Cys Glu Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Ser Leu Ser  Asp Gly Leu Cys Pro  His Gly Gln 
    1115                 1120                 1125             


Cys Val  Asn Val Ile Gly Ala  Phe Gln Cys Ser Cys  His Ala Gly 
    1130                 1135                 1140             


Phe Gln  Ser Thr Pro Asp Arg  Gln Gly Cys Val Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Arg  Val Gln Asn Gly Gly  Cys Asp Val His Cys  Ile Asn Thr 
    1160                 1165                 1170             


Glu Gly  Ser Tyr Arg Cys Ser  Cys Gly Gln Gly Tyr  Ser Leu Met 
    1175                 1180                 1185             


Pro Asp  Gly Arg Ala Cys Ala  Asp Val Asp Glu Cys  Glu Glu Asn 
    1190                 1195                 1200             


Pro Arg  Val Cys Asp Gln Gly  His Cys Thr Asn Met  Pro Gly Gly 
    1205                 1210                 1215             


His Arg  Cys Leu Cys Tyr Asp  Gly Phe Met Ala Thr  Pro Asp Met 
    1220                 1225                 1230             


Arg Thr  Cys Val Asp Val Asp  Glu Cys Asp Leu Asn  Pro His Ile 
    1235                 1240                 1245             


Cys Leu  His Gly Asp Cys Glu  Asn Thr Lys Gly Ser  Phe Val Cys 
    1250                 1255                 1260             


His Cys  Gln Leu Gly Tyr Met  Val Arg Lys Gly Ala  Thr Gly Cys 
    1265                 1270                 1275             


Ser Asp  Val Asp Glu Cys Glu  Val Gly Gly His Asn  Cys Asp Ser 
    1280                 1285                 1290             


His Ala  Ser Cys Leu Asn Ile  Pro Gly Ser Phe Ser  Cys Arg Cys 
    1295                 1300                 1305             


Leu Pro  Gly Trp Val Gly Asp  Gly Phe Glu Cys His  Asp Leu Asp 
    1310                 1315                 1320             


Glu Cys  Val Ser Gln Glu His  Arg Cys Ser Pro Arg  Gly Asp Cys 
    1325                 1330                 1335             


Leu Asn  Val Pro Gly Ser Tyr  Arg Cys Thr Cys Arg  Gln Gly Phe 
    1340                 1345                 1350             


Ala Gly  Asp Gly Phe Phe Cys  Glu Asp Arg Asp Glu  Cys Ala Glu 
    1355                 1360                 1365             


Asn Val  Asp Leu Cys Asp Asn  Gly Gln Cys Leu Asn  Ala Pro Gly 
    1370                 1375                 1380             


Gly Tyr  Arg Cys Glu Cys Glu  Met Gly Phe Asp Pro  Thr Glu Asp 
    1385                 1390                 1395             


His Arg  Ala Cys Gln Asp Val  Asp Glu Cys Ala Gln  Gly Asn Leu 
    1400                 1405                 1410             


Cys Ala  Phe Gly Ser Cys Glu  Asn Leu Pro Gly Met  Phe Arg Cys 
    1415                 1420                 1425             


Ile Cys  Asn Gly Gly Tyr Glu  Leu Asp Arg Gly Gly  Gly Asn Cys 
    1430                 1435                 1440             


Thr Asp  Ile Asn Glu Cys Ala  Asp Pro Val Asn Cys  Ile Asn Gly 
    1445                 1450                 1455             


Val Cys  Ile Asn Thr Pro Gly  Ser Tyr Leu Cys Ser  Cys Pro Gln 
    1460                 1465                 1470             


Asp Phe  Glu Leu Asn Pro Ser  Gly Val Gly Cys Val  Asp Thr Arg 
    1475                 1480                 1485             


Ala Gly  Asn Cys Phe Leu Glu  Thr His Asp Arg Gly  Asp Ser Gly 
    1490                 1495                 1500             


Ile Ser  Cys Ser Ala Glu Ile  Gly Val Gly Val Thr  Arg Ala Ser 
    1505                 1510                 1515             


Cys Cys  Cys Ser Leu Gly Arg  Ala Trp Gly Asn Pro  Cys Glu Leu 
    1520                 1525                 1530             


Cys Pro  Met Ala Asn Thr Thr  Glu Tyr Arg Thr Leu  Cys Pro Gly 
    1535                 1540                 1545             


Gly Glu  Gly Phe Gln Pro Asn  Arg Ile Thr Val Ile  Leu Glu Asp 
    1550                 1555                 1560             


Ile Asp  Glu Cys Gln Glu Leu  Pro Gly Leu Cys Gln  Gly Gly Asp 
    1565                 1570                 1575             


Cys Val  Asn Thr Phe Gly Ser  Phe Gln Cys Glu Cys  Pro Pro Gly 
    1580                 1585                 1590             


Tyr His  Leu Ser Glu His Thr  Arg Ile Cys Glu Asp  Ile Asp Glu 
    1595                 1600                 1605             


Cys Ser  Thr His Ser Gly Ile  Cys Gly Pro Gly Thr  Cys Tyr Asn 
    1610                 1615                 1620             


Thr Leu  Gly Asn Tyr Thr Cys  Val Cys Pro Ala Glu  Tyr Leu Gln 
    1625                 1630                 1635             


Val Asn  Gly Gly Asn Asn Cys  Met Asp Met Arg Lys  Ser Val Cys 
    1640                 1645                 1650             


Phe Arg  His Tyr Asn Gly Thr  Cys Gln Asn Glu Leu  Ala Phe Asn 
    1655                 1660                 1665             


Val Thr  Arg Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Gln Ala 
    1670                 1675                 1680             


Trp Asn  Arg Pro Cys Glu Ala  Cys Pro Thr Pro Ile  Ser Pro Asp 
    1685                 1690                 1695             


Tyr Gln  Ile Leu Cys Gly Asn  Gln Ala Pro Gly Phe  Leu Thr Asp 
    1700                 1705                 1710             


Ile His  Thr Gly Lys Pro Leu  Asp Ile Asp Glu Cys  Gly Glu Ile 
    1715                 1720                 1725             


Pro Ala  Ile Cys Ala Asn Gly  Ile Cys Ile Asn Gln  Ile Gly Ser 
    1730                 1735                 1740             


Phe Arg  Cys Glu Cys Pro Ala  Gly Phe Asn Tyr Asn  Ser Ile Leu 
    1745                 1750                 1755             


Leu Ala  Cys Glu Asp Val Asp  Glu Cys Gly Ser Arg  Glu Ser Pro 
    1760                 1765                 1770             


Cys Gln  Gln Asn Ala Asp Cys  Ile Asn Ile Pro Gly  Ser Tyr Arg 
    1775                 1780                 1785             


Cys Lys  Cys Thr Arg Gly Tyr  Lys Leu Ser Pro Gly  Gly Ala Cys 
    1790                 1795                 1800             


Val Gly  Arg Asn Glu Cys Arg  Glu Ile Pro Asn Val  Cys Ser His 
    1805                 1810                 1815             


Gly Asp  Cys Met Asp Thr Glu  Gly Ser Tyr Met Cys  Leu Cys His 
    1820                 1825                 1830             


Arg Gly  Phe Gln Ala Ser Ala  Asp Gln Thr Leu Cys  Met Asp Ile 
    1835                 1840                 1845             


Asp Glu  Cys Asp Arg Gln Pro  Cys Gly Asn Gly Thr  Cys Lys Asn 
    1850                 1855                 1860             


Ile Ile  Gly Ser Tyr Asn Cys  Leu Cys Phe Pro Gly  Phe Val Val 
    1865                 1870                 1875             


Thr His  Asn Gly Asp Cys Val  Asp Phe Asp Glu Cys  Thr Thr Leu 
    1880                 1885                 1890             


Val Gly  Gln Val Cys Arg Phe  Gly His Cys Leu Asn  Thr Ala Gly 
    1895                 1900                 1905             


Ser Phe  His Cys Leu Cys Gln  Asp Gly Phe Glu Leu  Thr Ala Asp 
    1910                 1915                 1920             


Gly Lys  Asn Cys Val Asp Thr  Asn Glu Cys Leu Ser  Leu Ala Gly 
    1925                 1930                 1935             


Thr Cys  Leu Pro Gly Thr Cys  Gln Asn Leu Glu Gly  Ser Phe Arg 
    1940                 1945                 1950             


Cys Ile  Cys Pro Pro Gly Phe  Gln Val Gln Ser Asp  His Cys Ile 
    1955                 1960                 1965             


Asp Ile  Asp Glu Cys Ser Glu  Glu Pro Asn Leu Cys  Leu Phe Gly 
    1970                 1975                 1980             


Thr Cys  Thr Asn Ser Pro Gly  Ser Phe Gln Cys Leu  Cys Pro Pro 
    1985                 1990                 1995             


Gly Phe  Val Leu Ser Asp Asn  Gly His Arg Cys Phe  Asp Thr Arg 
    2000                 2005                 2010             


Gln Ser  Phe Cys Phe Thr Arg  Phe Glu Ala Gly Lys  Cys Ser Val 
    2015                 2020                 2025             


Pro Lys  Ala Phe Asn Thr Thr  Lys Thr Arg Cys Cys  Cys Ser Lys 
    2030                 2035                 2040             


Arg Pro  Gly Glu Gly Trp Gly  Asp Pro Cys Glu Leu  Cys Pro Gln 
    2045                 2050                 2055             


Glu Gly  Ser Ala Ala Phe Gln  Glu Leu Cys Pro Phe  Gly His Gly 
    2060                 2065                 2070             


Ala Val  Pro Gly Pro Asp Asp  Ser Arg Glu Asp Val  Asn Glu Cys 
    2075                 2080                 2085             


Ala Glu  Asn Pro Gly Val Cys  Thr Asn Gly Val Cys  Val Asn Thr 
    2090                 2095                 2100             


Asp Gly  Ser Phe Arg Cys Glu  Cys Pro Phe Gly Tyr  Ser Leu Asp 
    2105                 2110                 2115             


Phe Thr  Gly Ile Asn Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly 
    2120                 2125                 2130             


His Pro  Cys Gly Gln Gly Thr  Cys Thr Asn Val Ile  Gly Gly Phe 
    2135                 2140                 2145             


Glu Cys  Ala Cys Ala Asp Gly  Phe Glu Pro Gly Leu  Met Met Thr 
    2150                 2155                 2160             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Asn Pro Leu  Leu Cys Ala 
    2165                 2170                 2175             


Phe Arg  Cys His Asn Thr Glu  Gly Ser Tyr Leu Cys  Thr Cys Pro 
    2180                 2185                 2190             


Ala Gly  Tyr Thr Leu Arg Glu  Asp Gly Ala Met Cys  Arg Asp Val 
    2195                 2200                 2205             


Asp Glu  Cys Ala Asp Gly Gln  Gln Asp Cys His Ala  Arg Gly Met 
    2210                 2215                 2220             


Glu Cys  Lys Asn Leu Ile Gly  Thr Phe Ala Cys Val  Cys Pro Pro 
    2225                 2230                 2235             


Gly Met  Arg Pro Leu Pro Gly  Ser Gly Glu Gly Cys  Thr Asp Asp 
    2240                 2245                 2250             


Asn Glu  Cys His Ala Gln Pro  Asp Leu Cys Val Asn  Gly Arg Cys 
    2255                 2260                 2265             


Val Asn  Thr Ala Gly Ser Phe  Arg Cys Asp Cys Asp  Glu Gly Phe 
    2270                 2275                 2280             


Gln Pro  Ser Pro Thr Leu Thr  Glu Cys His Asp Ile  Arg Gln Gly 
    2285                 2290                 2295             


Pro Cys  Phe Ala Glu Val Leu  Gln Thr Met Cys Arg  Ser Leu Ser 
    2300                 2305                 2310             


Ser Ser  Ser Glu Ala Val Thr  Arg Ala Glu Cys Cys  Cys Gly Gly 
    2315                 2320                 2325             


Gly Arg  Gly Trp Gly Pro Arg  Cys Glu Leu Cys Pro  Leu Pro Gly 
    2330                 2335                 2340             


Thr Ser  Ala Tyr Arg Lys Leu  Cys Pro His Gly Ser  Gly Tyr Thr 
    2345                 2350                 2355             


Ala Glu  Gly Arg Asp Val Asp  Glu Cys Arg Met Leu  Ala His Leu 
    2360                 2365                 2370             


Cys Ala  His Gly Glu Cys Ile  Asn Ser Leu Gly Ser  Phe Arg Cys 
    2375                 2380                 2385             


His Cys  Gln Ala Gly Tyr Thr  Pro Asp Ala Thr Ala  Thr Thr Cys 
    2390                 2395                 2400             


Leu Asp  Met Asp Glu Cys Ser  Gln Val Pro Lys Pro  Cys Thr Phe 
    2405                 2410                 2415             


Leu Cys  Lys Asn Thr Lys Gly  Ser Phe Leu Cys Ser  Cys Pro Arg 
    2420                 2425                 2430             


Gly Tyr  Leu Leu Glu Glu Asp  Gly Arg Thr Cys Lys  Asp Leu Asp 
    2435                 2440                 2445             


Glu Cys  Thr Ser Arg Gln His  Asn Cys Gln Phe Leu  Cys Val Asn 
    2450                 2455                 2460             


Thr Val  Gly Ala Phe Thr Cys  Arg Cys Pro Pro Gly  Phe Thr Gln 
    2465                 2470                 2475             


His His  Gln Ala Cys Phe Asp  Asn Asp Glu Cys Ser  Ala Gln Pro 
    2480                 2485                 2490             


Gly Pro  Cys Gly Ala His Gly  His Cys His Asn Thr  Pro Gly Ser 
    2495                 2500                 2505             


Phe Arg  Cys Glu Cys His Gln  Gly Phe Thr Leu Val  Ser Ser Gly 
    2510                 2515                 2520             


His Gly  Cys Glu Asp Val Asn  Glu Cys Asp Gly Pro  His Arg Cys 
    2525                 2530                 2535             


Gln His  Gly Cys Gln Asn Gln  Leu Gly Gly Tyr Arg  Cys Ser Cys 
    2540                 2545                 2550             


Pro Gln  Gly Phe Thr Gln His  Ser Gln Trp Ala Gln  Cys Val Asp 
    2555                 2560                 2565             


Glu Asn  Glu Cys Ala Leu Ser  Pro Pro Thr Cys Gly  Ser Ala Ser 
    2570                 2575                 2580             


Cys Arg  Asn Thr Leu Gly Gly  Phe Arg Cys Val Cys  Pro Ser Gly 
    2585                 2590                 2595             


Phe Asp  Phe Asp Gln Ala Leu  Gly Gly Cys Gln Glu  Val Asp Glu 
    2600                 2605                 2610             


Cys Ala  Gly Arg Arg Gly Pro  Cys Ser Tyr Ser Cys  Ala Asn Thr 
    2615                 2620                 2625             


Pro Gly  Gly Phe Leu Cys Gly  Cys Pro Gln Gly Tyr  Phe Arg Ala 
    2630                 2635                 2640             


Gly Gln  Gly His Cys Val Ser  Gly Leu Gly Phe Ser  Pro Gly Pro 
    2645                 2650                 2655             


Gln Asp  Thr Pro Asp Lys Glu  Glu Leu Leu Ser Ser  Glu Ala Cys 
    2660                 2665                 2670             


Tyr Glu  Cys Lys Ile Asn Gly  Leu Ser Pro Arg Asp  Arg Pro Arg 
    2675                 2680                 2685             


Arg Ser  Ala His Arg Asp His  Gln Val Asn Leu Ala  Thr Leu Asp 
    2690                 2695                 2700             


Ser Glu  Ala Leu Leu Thr Leu  Gly Leu Asn Leu Ser  His Leu Gly 
    2705                 2710                 2715             


Arg Ala  Glu Arg Ile Leu Glu  Leu Arg Pro Ala Leu  Glu Gly Leu 
    2720                 2725                 2730             


Glu Gly  Arg Ile Arg Tyr Val  Ile Val Arg Gly Asn  Glu Gln Gly 
    2735                 2740                 2745             


Phe Phe  Arg Met His His Leu  Arg Gly Val Ser Ser  Leu Gln Leu 
    2750                 2755                 2760             


Gly Arg  Arg Arg Pro Gly Pro  Gly Thr Tyr Arg Leu  Glu Val Val 
    2765                 2770                 2775             


Ser His  Met Ala Gly Pro Trp  Gly Val Gln Pro Glu  Gly Gln Pro 
    2780                 2785                 2790             


Gly Pro  Trp Gly Gln Ala Leu  Arg Leu Lys Val Gln  Leu Gln Leu 
    2795                 2800                 2805             


Leu 
    


<210>  36
<211>  1256
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Pro Gly Pro Arg Gly Ala Ala Gly Gly Leu Ala Pro Glu Met Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Gly Leu Leu Ala Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Gly Gly Arg Val Glu Gly Gly Pro Ala Gly Glu 
        35                  40                  45              


Arg Gly Ala Gly Gly Gly Gly Ala Leu Ala Arg Glu Arg Phe Lys Val 
    50                  55                  60                  


Val Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
65                  70                  75                  80  


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
                85                  90                  95      


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val Val Val 
            100                 105                 110         


Cys Pro Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asn Gln 
        115                 120                 125             


Cys Leu Cys Pro Pro Asp Phe Thr Gly Arg Phe Cys Gln Val Pro Ala 
    130                 135                 140                 


Gly Gly Ala Gly Gly Gly Thr Gly Gly Ser Gly Pro Gly Leu Ser Arg 
145                 150                 155                 160 


Thr Gly Ala Leu Ser Thr Gly Ala Leu Pro Pro Leu Ala Pro Glu Gly 
                165                 170                 175     


Asp Ser Val Ala Ser Lys His Ala Ile Tyr Ala Val Gln Val Ile Ala 
            180                 185                 190         


Asp Pro Pro Gly Pro Gly Glu Gly Pro Pro Ala Gln His Ala Ala Phe 
        195                 200                 205             


Leu Val Pro Leu Gly Pro Gly Gln Ile Ser Ala Glu Val Gln Ala Pro 
    210                 215                 220                 


Pro Pro Val Val Asn Val Arg Val His His Pro Pro Glu Ala Ser Val 
225                 230                 235                 240 


Gln Val His Arg Ile Glu Ser Ser Asn Ala Glu Ser Ala Ala Pro Ser 
                245                 250                 255     


Gln His Leu Leu Pro His Pro Lys Pro Ser His Pro Arg Pro Pro Thr 
            260                 265                 270         


Gln Lys Pro Leu Gly Arg Cys Phe Gln Asp Thr Leu Pro Lys Gln Pro 
        275                 280                 285             


Cys Gly Ser Asn Pro Leu Pro Gly Leu Thr Lys Gln Glu Asp Cys Cys 
    290                 295                 300                 


Gly Ser Ile Gly Thr Ala Trp Gly Gln Ser Lys Cys His Lys Cys Pro 
305                 310                 315                 320 


Gln Leu Gln Tyr Thr Gly Val Gln Lys Pro Gly Pro Val Arg Gly Glu 
                325                 330                 335     


Val Gly Ala Asp Cys Pro Gln Gly Tyr Lys Arg Leu Asn Ser Thr His 
            340                 345                 350         


Cys Gln Asp Ile Asn Glu Cys Ala Met Pro Gly Val Cys Arg His Gly 
        355                 360                 365             


Asp Cys Leu Asn Asn Pro Gly Ser Tyr Arg Cys Val Cys Pro Pro Gly 
    370                 375                 380                 


His Ser Leu Gly Pro Ser Arg Thr Gln Cys Ile Ala Asp Lys Pro Glu 
385                 390                 395                 400 


Glu Lys Ser Leu Cys Phe Arg Leu Val Ser Pro Glu His Gln Cys Gln 
                405                 410                 415     


His Pro Leu Thr Thr Arg Leu Thr Arg Gln Leu Cys Cys Cys Ser Val 
            420                 425                 430         


Gly Lys Ala Trp Gly Ala Arg Cys Gln Arg Cys Pro Thr Asp Gly Thr 
        435                 440                 445             


Ala Ala Phe Lys Glu Ile Cys Pro Ala Gly Lys Gly Tyr His Ile Leu 
    450                 455                 460                 


Thr Ser His Gln Thr Leu Thr Ile Gln Gly Glu Ser Asp Phe Ser Leu 
465                 470                 475                 480 


Phe Leu His Pro Asp Gly Pro Pro Lys Pro Gln Gln Leu Pro Glu Ser 
                485                 490                 495     


Pro Ser Gln Ala Pro Pro Pro Glu Asp Thr Glu Glu Glu Arg Gly Val 
            500                 505                 510         


Thr Thr Asp Ser Pro Val Ser Glu Glu Arg Ser Val Gln Gln Ser His 
        515                 520                 525             


Pro Thr Ala Thr Thr Thr Pro Ala Arg Pro Tyr Pro Glu Leu Ile Ser 
    530                 535                 540                 


Arg Pro Ser Pro Pro Thr Met Arg Trp Phe Leu Pro Asp Leu Pro Pro 
545                 550                 555                 560 


Ser Arg Ser Ala Val Glu Ile Ala Pro Thr Gln Val Thr Glu Thr Asp 
                565                 570                 575     


Glu Cys Arg Leu Asn Gln Asn Ile Cys Gly His Gly Glu Cys Val Pro 
            580                 585                 590         


Gly Pro Pro Asp Tyr Ser Cys His Cys Asn Pro Gly Tyr Arg Ser His 
        595                 600                 605             


Pro Gln His Arg Tyr Cys Val Asp Val Asn Glu Cys Glu Ala Glu Pro 
    610                 615                 620                 


Cys Gly Pro Gly Arg Gly Ile Cys Met Asn Thr Gly Gly Ser Tyr Asn 
625                 630                 635                 640 


Cys His Cys Asn Arg Gly Tyr Arg Leu His Val Gly Ala Gly Gly Arg 
                645                 650                 655     


Ser Cys Val Asp Leu Asn Glu Cys Ala Lys Pro His Leu Cys Gly Asp 
            660                 665                 670         


Gly Gly Phe Cys Ile Asn Phe Pro Gly His Tyr Lys Cys Asn Cys Tyr 
        675                 680                 685             


Pro Gly Tyr Arg Leu Lys Ala Ser Arg Pro Pro Val Cys Glu Asp Ile 
    690                 695                 700                 


Asp Glu Cys Arg Asp Pro Ser Ser Cys Pro Asp Gly Lys Cys Glu Asn 
705                 710                 715                 720 


Lys Pro Gly Ser Phe Lys Cys Ile Ala Cys Gln Pro Gly Tyr Arg Ser 
                725                 730                 735     


Gln Gly Gly Gly Ala Cys Arg Asp Val Asn Glu Cys Ala Glu Gly Ser 
            740                 745                 750         


Pro Cys Ser Pro Gly Trp Cys Glu Asn Leu Pro Gly Ser Phe Arg Cys 
        755                 760                 765             


Thr Cys Ala Gln Gly Tyr Ala Pro Ala Pro Asp Gly Arg Ser Cys Leu 
    770                 775                 780                 


Asp Val Asp Glu Cys Glu Ala Gly Asp Val Cys Asp Asn Gly Ile Cys 
785                 790                 795                 800 


Ser Asn Thr Pro Gly Ser Phe Gln Cys Gln Cys Leu Ser Gly Tyr His 
                805                 810                 815     


Leu Ser Arg Asp Arg Ser His Cys Glu Asp Ile Asp Glu Cys Asp Phe 
            820                 825                 830         


Pro Ala Ala Cys Ile Gly Gly Asp Cys Ile Asn Thr Asn Gly Ser Tyr 
        835                 840                 845             


Arg Cys Leu Cys Pro Gln Gly His Arg Leu Val Gly Gly Arg Lys Cys 
    850                 855                 860                 


Gln Asp Ile Asp Glu Cys Ser Gln Asp Pro Ser Leu Cys Leu Pro His 
865                 870                 875                 880 


Gly Ala Cys Lys Asn Leu Gln Gly Ser Tyr Val Cys Val Cys Asp Glu 
                885                 890                 895     


Gly Phe Thr Pro Thr Gln Asp Gln His Gly Cys Glu Glu Val Glu Gln 
            900                 905                 910         


Pro His His Lys Lys Glu Cys Tyr Leu Asn Phe Asp Asp Thr Val Phe 
        915                 920                 925             


Cys Asp Ser Val Leu Ala Thr Asn Val Thr Gln Gln Glu Cys Cys Cys 
    930                 935                 940                 


Ser Leu Gly Ala Gly Trp Gly Asp His Cys Glu Ile Tyr Pro Cys Pro 
945                 950                 955                 960 


Val Tyr Ser Ser Ala Glu Phe His Ser Leu Cys Pro Asp Gly Lys Gly 
                965                 970                 975     


Tyr Thr Gln Asp Asn Asn Ile Val Asn Tyr Gly Ile Pro Ala His Arg 
            980                 985                 990         


Asp Ile Asp Glu Cys Met Leu Phe  Gly Ser Glu Ile Cys  Lys Glu Gly 
        995                 1000                 1005             


Lys Cys  Val Asn Thr Gln Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1010                 1015                 1020             


Gly Phe  Tyr Tyr Asp Gly Asn  Leu Leu Glu Cys Val  Asp Val Asp 
    1025                 1030                 1035             


Glu Cys  Leu Asp Glu Ser Asn  Cys Arg Asn Gly Val  Cys Glu Asn 
    1040                 1045                 1050             


Thr Arg  Gly Gly Tyr Arg Cys  Ala Cys Thr Pro Pro  Ala Glu Tyr 
    1055                 1060                 1065             


Ser Pro  Ala Gln Arg Gln Cys  Leu Ser Pro Glu Glu  Met Glu Arg 
    1070                 1075                 1080             


Ala Pro  Glu Arg Arg Asp Val  Cys Trp Ser Gln Arg  Gly Glu Asp 
    1085                 1090                 1095             


Gly Met  Cys Ala Gly Pro Leu  Ala Gly Pro Ala Leu  Thr Phe Asp 
    1100                 1105                 1110             


Asp Cys  Cys Cys Arg Gln Gly  Arg Gly Trp Gly Ala  Gln Cys Arg 
    1115                 1120                 1125             


Pro Cys  Pro Pro Arg Gly Ala  Gly Ser His Cys Pro  Thr Ser Gln 
    1130                 1135                 1140             


Ser Glu  Ser Asn Ser Phe Trp  Asp Thr Ser Pro Leu  Leu Leu Gly 
    1145                 1150                 1155             


Lys Pro  Pro Arg Asp Glu Asp  Ser Ser Glu Glu Asp  Ser Asp Glu 
    1160                 1165                 1170             


Cys Arg  Cys Val Ser Gly Arg  Cys Val Pro Arg Pro  Gly Gly Ala 
    1175                 1180                 1185             


Val Cys  Glu Cys Pro Gly Gly  Phe Gln Leu Asp Ala  Ser Arg Ala 
    1190                 1195                 1200             


Arg Cys  Val Asp Ile Asp Glu  Cys Arg Glu Leu Asn  Gln Arg Gly 
    1205                 1210                 1215             


Leu Leu  Cys Lys Ser Glu Arg  Cys Val Asn Thr Ser  Gly Ser Phe 
    1220                 1225                 1230             


Arg Cys  Val Cys Lys Ala Gly  Phe Ala Arg Ser Arg  Pro His Gly 
    1235                 1240                 1245             


Ala Cys  Val Pro Gln Arg Arg  Arg 
    1250                 1255     


<210>  37
<211>  1823
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser 
            260                 265                 270         


Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Ala Leu Arg Leu Ala Ala 
        275                 280                 285             


Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly 
    290                 295                 300                 


Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys 
                325                 330                 335     


Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp 
            340                 345                 350         


Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln 
        355                 360                 365             


Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu 
    370                 375                 380                 


Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn 
385                 390                 395                 400 


Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile 
                405                 410                 415     


Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser 
            420                 425                 430         


Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp 
        435                 440                 445             


Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His 
    450                 455                 460                 


Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp 
465                 470                 475                 480 


Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu 
                485                 490                 495     


Asn Tyr Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg 
            500                 505                 510         


Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu 
        515                 520                 525             


Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro 
    530                 535                 540                 


Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly 
545                 550                 555                 560 


Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu 
                565                 570                 575     


Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp 
            580                 585                 590         


His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu 
        595                 600                 605             


His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser 
    610                 615                 620                 


Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr 
625                 630                 635                 640 


Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser 
                645                 650                 655     


Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu 
            660                 665                 670         


Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp 
        675                 680                 685             


Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg 
    690                 695                 700                 


Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln 
705                 710                 715                 720 


Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu 
                725                 730                 735     


Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr 
            740                 745                 750         


Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His 
        755                 760                 765             


Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala 
    770                 775                 780                 


Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg 
785                 790                 795                 800 


Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln 
                805                 810                 815     


Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile 
            820                 825                 830         


Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser 
        835                 840                 845             


Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr 
    850                 855                 860                 


Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln 
865                 870                 875                 880 


Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly 
                885                 890                 895     


Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr 
            900                 905                 910         


Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro 
        915                 920                 925             


Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys 
    930                 935                 940                 


Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe 
945                 950                 955                 960 


Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp 
                965                 970                 975     


Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys 
            980                 985                 990         


Leu Pro Thr Ser Leu Asn Leu Pro  Gly Phe Val Gly Cys  Leu Glu Leu 
        995                 1000                 1005             


Ala Thr  Leu Asn Asn Asp Val  Ile Ser Leu Tyr Asn  Phe Lys His 
    1010                 1015                 1020             


Ile Tyr  Asn Met Asp Pro Ser  Thr Ser Val Pro Cys  Ala Arg Asp 
    1025                 1030                 1035             


Lys Leu  Ala Phe Thr Gln Ser  Arg Ala Ala Ser Tyr  Phe Phe Asp 
    1040                 1045                 1050             


Gly Ser  Gly Tyr Ala Val Val  Arg Asp Ile Thr Arg  Arg Gly Lys 
    1055                 1060                 1065             


Phe Gly  Gln Val Thr Arg Phe  Asp Ile Glu Val Arg  Thr Pro Ala 
    1070                 1075                 1080             


Asp Asn  Gly Leu Ile Leu Leu  Met Val Asn Gly Ser  Met Phe Phe 
    1085                 1090                 1095             


Arg Leu  Glu Met Arg Asn Gly  Tyr Leu His Val Phe  Tyr Asp Phe 
    1100                 1105                 1110             


Gly Phe  Ser Gly Gly Pro Val  His Leu Glu Asp Thr  Leu Lys Lys 
    1115                 1120                 1125             


Ala Gln  Ile Asn Asp Ala Lys  Tyr His Glu Ile Ser  Ile Ile Tyr 
    1130                 1135                 1140             


His Asn  Asp Lys Lys Met Ile  Leu Val Val Asp Arg  Arg His Val 
    1145                 1150                 1155             


Lys Ser  Met Asp Asn Glu Lys  Met Lys Ile Pro Phe  Thr Asp Ile 
    1160                 1165                 1170             


Tyr Ile  Gly Gly Ala Pro Pro  Glu Ile Leu Gln Ser  Arg Ala Leu 
    1175                 1180                 1185             


Arg Ala  His Leu Pro Leu Asp  Ile Asn Phe Arg Gly  Cys Met Lys 
    1190                 1195                 1200             


Gly Phe  Gln Phe Gln Lys Lys  Asp Phe Asn Leu Leu  Glu Gln Thr 
    1205                 1210                 1215             


Glu Thr  Leu Gly Val Gly Tyr  Gly Cys Pro Glu Asp  Ser Leu Ile 
    1220                 1225                 1230             


Ser Arg  Arg Ala Tyr Phe Asn  Gly Gln Ser Phe Ile  Ala Ser Ile 
    1235                 1240                 1245             


Gln Lys  Ile Ser Phe Phe Asp  Gly Phe Glu Gly Gly  Phe Asn Phe 
    1250                 1255                 1260             


Arg Thr  Leu Gln Pro Asn Gly  Leu Leu Phe Tyr Tyr  Ala Ser Gly 
    1265                 1270                 1275             


Ser Asp  Val Phe Ser Ile Ser  Leu Asp Asn Gly Thr  Val Ile Met 
    1280                 1285                 1290             


Asp Val  Lys Gly Ile Lys Val  Gln Ser Val Asp Lys  Gln Tyr Asn 
    1295                 1300                 1305             


Asp Gly  Leu Ser His Phe Val  Ile Ser Ser Val Ser  Pro Thr Arg 
    1310                 1315                 1320             


Tyr Glu  Leu Ile Val Asp Lys  Ser Arg Val Gly Ser  Lys Asn Pro 
    1325                 1330                 1335             


Thr Lys  Gly Lys Ile Glu Gln  Thr Gln Ala Ser Glu  Lys Lys Phe 
    1340                 1345                 1350             


Tyr Phe  Gly Gly Ser Pro Ile  Ser Ala Gln Tyr Ala  Asn Phe Thr 
    1355                 1360                 1365             


Gly Cys  Ile Ser Asn Ala Tyr  Phe Thr Arg Val Asp  Arg Asp Val 
    1370                 1375                 1380             


Glu Val  Glu Asp Phe Gln Arg  Tyr Thr Glu Lys Val  His Thr Ser 
    1385                 1390                 1395             


Leu Tyr  Glu Cys Pro Ile Glu  Ser Ser Pro Leu Phe  Leu Leu His 
    1400                 1405                 1410             


Lys Lys  Gly Lys Asn Leu Ser  Lys Pro Lys Ala Ser  Gln Asn Lys 
    1415                 1420                 1425             


Lys Gly  Gly Lys Ser Lys Asp  Ala Pro Ser Trp Asp  Pro Val Ala 
    1430                 1435                 1440             


Leu Lys  Leu Pro Glu Arg Asn  Thr Pro Arg Asn Ser  His Cys His 
    1445                 1450                 1455             


Leu Ser  Asn Ser Pro Arg Ala  Ile Glu His Ala Tyr  Gln Tyr Gly 
    1460                 1465                 1470             


Gly Thr  Ala Asn Ser Arg Gln  Glu Phe Glu His Leu  Lys Gly Asp 
    1475                 1480                 1485             


Phe Gly  Ala Lys Ser Gln Phe  Ser Ile Arg Leu Arg  Thr Arg Ser 
    1490                 1495                 1500             


Ser His  Gly Met Ile Phe Tyr  Val Ser Asp Gln Glu  Glu Asn Asp 
    1505                 1510                 1515             


Phe Met  Thr Leu Phe Leu Ala  His Gly Arg Leu Val  Tyr Met Phe 
    1520                 1525                 1530             


Asn Val  Gly His Lys Lys Leu  Lys Ile Arg Ser Gln  Glu Lys Tyr 
    1535                 1540                 1545             


Asn Asp  Gly Leu Trp His Asp  Val Ile Phe Ile Arg  Glu Arg Ser 
    1550                 1555                 1560             


Ser Gly  Arg Leu Val Ile Asp  Gly Leu Arg Val Leu  Glu Glu Ser 
    1565                 1570                 1575             


Leu Pro  Pro Thr Glu Ala Thr  Trp Lys Ile Lys Gly  Pro Ile Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Val Ala Pro Gly  Lys Ala Val Lys Asn  Val Gln Ile 
    1595                 1600                 1605             


Asn Ser  Ile Tyr Ser Phe Ser  Gly Cys Leu Ser Asn  Leu Gln Leu 
    1610                 1615                 1620             


Asn Gly  Ala Ser Ile Thr Ser  Ala Ser Gln Thr Phe  Ser Val Thr 
    1625                 1630                 1635             


Pro Cys  Phe Glu Gly Pro Met  Glu Thr Gly Thr Tyr  Phe Ser Thr 
    1640                 1645                 1650             


Glu Gly  Gly Tyr Val Val Leu  Asp Glu Ser Phe Asn  Ile Gly Leu 
    1655                 1660                 1665             


Lys Phe  Glu Ile Ala Phe Glu  Val Arg Pro Arg Ser  Ser Ser Gly 
    1670                 1675                 1680             


Thr Leu  Val His Gly His Ser  Val Asn Gly Glu Tyr  Leu Asn Val 
    1685                 1690                 1695             


His Met  Lys Asn Gly Gln Val  Ile Val Lys Val Asn  Asn Gly Ile 
    1700                 1705                 1710             


Arg Asp  Phe Ser Thr Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp 
    1715                 1720                 1725             


Gly Arg  Trp His Arg Ile Thr  Val Ile Arg Asp Ser  Asn Val Val 
    1730                 1735                 1740             


Gln Leu  Asp Val Asp Ser Glu  Val Asn His Val Val  Gly Pro Leu 
    1745                 1750                 1755             


Asn Pro  Lys Pro Ile Asp His  Arg Glu Pro Val Phe  Val Gly Gly 
    1760                 1765                 1770             


Val Pro  Glu Ser Leu Leu Thr  Pro Arg Leu Ala Pro  Ser Lys Pro 
    1775                 1780                 1785             


Phe Thr  Gly Cys Ile Arg His  Phe Val Ile Asp Gly  His Pro Val 
    1790                 1795                 1800             


Ser Phe  Ser Lys Ala Ala Leu  Val Ser Gly Ala Val  Ser Ile Asn 
    1805                 1810                 1815             


Ser Cys  Pro Ala Ala 
    1820             


<210>  38
<211>  2551
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Met Leu Gln His Leu Val Ile Phe Cys Leu Gly Leu Val Val Gln 
1               5                   10                  15      


Asn Phe Cys Ser Pro Ala Glu Thr Thr Gly Gln Ala Arg Arg Cys Asp 
            20                  25                  30          


Arg Lys Ser Leu Leu Thr Ile Arg Thr Glu Cys Arg Ser Cys Ala Leu 
        35                  40                  45              


Asn Leu Gly Val Lys Cys Pro Asp Gly Tyr Thr Met Ile Thr Ser Gly 
    50                  55                  60                  


Ser Val Gly Val Arg Asp Cys Arg Tyr Thr Phe Glu Val Arg Thr Tyr 
65                  70                  75                  80  


Ser Leu Ser Leu Pro Gly Cys Arg His Ile Cys Arg Lys Asp Tyr Leu 
                85                  90                  95      


Gln Pro Arg Cys Cys Pro Gly Arg Trp Gly Pro Asp Cys Ile Glu Cys 
            100                 105                 110         


Pro Gly Gly Ala Gly Ser Pro Cys Asn Gly Arg Gly Ser Cys Ala Glu 
        115                 120                 125             


Gly Met Glu Gly Asn Gly Thr Cys Ser Cys Gln Glu Gly Phe Gly Gly 
    130                 135                 140                 


Thr Ala Cys Glu Thr Cys Ala Asp Asp Asn Leu Phe Gly Pro Ser Cys 
145                 150                 155                 160 


Ser Ser Val Cys Asn Cys Val His Gly Val Cys Asn Ser Gly Leu Asp 
                165                 170                 175     


Gly Asp Gly Thr Cys Glu Cys Tyr Ser Ala Tyr Thr Gly Pro Lys Cys 
            180                 185                 190         


Asp Lys Pro Ile Pro Glu Cys Ala Ala Leu Leu Cys Pro Glu Asn Ser 
        195                 200                 205             


Arg Cys Ser Pro Ser Thr Glu Asp Glu Asn Lys Leu Glu Cys Lys Cys 
    210                 215                 220                 


Leu Pro Asn Tyr Arg Gly Asp Gly Lys Tyr Cys Asp Pro Ile Asn Pro 
225                 230                 235                 240 


Cys Leu Arg Lys Ile Cys His Pro His Ala His Cys Thr Tyr Leu Gly 
                245                 250                 255     


Pro Asn Arg His Ser Cys Thr Cys Gln Glu Gly Tyr Arg Gly Asp Gly 
            260                 265                 270         


Gln Val Cys Leu Pro Val Asp Pro Cys Gln Ile Asn Phe Gly Asn Cys 
        275                 280                 285             


Pro Thr Lys Ser Thr Val Cys Lys Tyr Asp Gly Pro Gly Gln Ser His 
    290                 295                 300                 


Cys Glu Cys Lys Glu His Tyr Gln Asn Phe Val Pro Gly Val Gly Cys 
305                 310                 315                 320 


Ser Met Thr Asp Ile Cys Lys Ser Asp Asn Pro Cys His Arg Asn Ala 
                325                 330                 335     


Asn Cys Thr Thr Val Ala Pro Gly Arg Thr Glu Cys Ile Cys Gln Lys 
            340                 345                 350         


Gly Tyr Val Gly Asp Gly Leu Thr Cys Tyr Gly Asn Ile Met Glu Arg 
        355                 360                 365             


Leu Arg Glu Leu Asn Thr Glu Pro Arg Gly Lys Trp Gln Gly Arg Leu 
    370                 375                 380                 


Thr Ser Phe Ile Ser Leu Leu Asp Lys Ala Tyr Ala Trp Pro Leu Ser 
385                 390                 395                 400 


Lys Leu Gly Pro Phe Thr Val Leu Leu Pro Thr Asp Lys Gly Leu Lys 
                405                 410                 415     


Gly Phe Asn Val Asn Glu Leu Leu Val Asp Asn Lys Ala Ala Gln Tyr 
            420                 425                 430         


Phe Val Lys Leu His Ile Ile Ala Gly Gln Met Asn Ile Glu Tyr Met 
        435                 440                 445             


Asn Asn Thr Asp Met Phe Tyr Thr Leu Thr Gly Lys Ser Gly Glu Ile 
    450                 455                 460                 


Phe Asn Ser Asp Lys Asp Asn Gln Ile Lys Leu Lys Leu His Gly Gly 
465                 470                 475                 480 


Lys Lys Lys Val Lys Ile Ile Gln Gly Asp Ile Ile Ala Ser Asn Gly 
                485                 490                 495     


Leu Leu His Ile Leu Asp Arg Ala Met Asp Lys Leu Glu Pro Thr Phe 
            500                 505                 510         


Glu Ser Asn Asn Glu Gln Thr Ile Met Thr Met Leu Gln Pro Arg Tyr 
        515                 520                 525             


Ser Lys Phe Arg Ser Leu Leu Glu Glu Thr Asn Leu Gly His Ala Leu 
    530                 535                 540                 


Asp Glu Asp Gly Val Gly Gly Pro Tyr Thr Ile Phe Val Pro Asn Asn 
545                 550                 555                 560 


Glu Ala Leu Asn Asn Met Lys Asp Gly Thr Leu Asp Tyr Leu Leu Ser 
                565                 570                 575     


Pro Glu Gly Ser Arg Lys Leu Leu Glu Leu Val Arg Tyr His Ile Val 
            580                 585                 590         


Pro Phe Thr Gln Leu Glu Val Ala Thr Leu Ile Ser Thr Pro His Ile 
        595                 600                 605             


Arg Ser Met Ala Asn Gln Leu Ile Gln Phe Asn Thr Thr Asp Asn Gly 
    610                 615                 620                 


Gln Ile Leu Ala Asn Asp Val Ala Met Glu Glu Ile Glu Ile Thr Ala 
625                 630                 635                 640 


Lys Asn Gly Arg Ile Tyr Thr Leu Thr Gly Val Leu Ile Pro Pro Ser 
                645                 650                 655     


Ile Val Pro Ile Leu Pro His Arg Cys Asp Glu Thr Lys Arg Glu Met 
            660                 665                 670         


Lys Leu Gly Thr Cys Val Ser Cys Ser Leu Val Tyr Trp Ser Arg Cys 
        675                 680                 685             


Pro Ala Asn Ser Glu Pro Thr Ala Leu Phe Thr His Arg Cys Val Tyr 
    690                 695                 700                 


Ser Gly Arg Phe Gly Ser Leu Lys Ser Gly Cys Ala Arg Tyr Cys Asn 
705                 710                 715                 720 


Ala Thr Val Lys Ile Pro Lys Cys Cys Lys Gly Phe Tyr Gly Pro Asp 
                725                 730                 735     


Cys Asn Gln Cys Pro Gly Gly Phe Ser Asn Pro Cys Ser Gly Asn Gly 
            740                 745                 750         


Gln Cys Ala Asp Ser Leu Gly Gly Asn Gly Thr Cys Ile Cys Glu Glu 
        755                 760                 765             


Gly Phe Gln Gly Ser Gln Cys Gln Phe Cys Ser Asp Pro Asn Lys Tyr 
    770                 775                 780                 


Gly Pro Arg Cys Asn Lys Lys Cys Leu Cys Val His Gly Thr Cys Asn 
785                 790                 795                 800 


Asn Arg Ile Asp Ser Asp Gly Ala Cys Leu Thr Gly Thr Cys Arg Asp 
                805                 810                 815     


Gly Ser Ala Gly Arg Leu Cys Asp Lys Gln Thr Ser Ala Cys Gly Pro 
            820                 825                 830         


Tyr Val Gln Phe Cys His Ile His Ala Thr Cys Glu Tyr Ser Asn Gly 
        835                 840                 845             


Thr Ala Ser Cys Ile Cys Lys Ala Gly Tyr Glu Gly Asp Gly Thr Leu 
    850                 855                 860                 


Cys Ser Glu Met Asp Pro Cys Thr Gly Leu Thr Pro Gly Gly Cys Ser 
865                 870                 875                 880 


Arg Asn Ala Glu Cys Ile Lys Thr Gly Thr Gly Thr His Thr Cys Val 
                885                 890                 895     


Cys Gln Gln Gly Trp Thr Gly Asn Gly Arg Asp Cys Ser Glu Ile Asn 
            900                 905                 910         


Asn Cys Leu Leu Pro Ser Ala Gly Gly Cys His Asp Asn Ala Ser Cys 
        915                 920                 925             


Leu Tyr Val Gly Pro Gly Gln Asn Glu Cys Glu Cys Lys Lys Gly Phe 
    930                 935                 940                 


Arg Gly Asn Gly Ile Asp Cys Glu Pro Ile Thr Ser Cys Leu Glu Gln 
945                 950                 955                 960 


Thr Gly Lys Cys His Pro Leu Ala Ser Cys Gln Ser Thr Ser Ser Gly 
                965                 970                 975     


Val Trp Ser Cys Val Cys Gln Glu Gly Tyr Glu Gly Asp Gly Phe Leu 
            980                 985                 990         


Cys Tyr Gly Asn Ala Ala Val Glu  Leu Ser Phe Leu Ser  Glu Ala Ala 
        995                 1000                 1005             


Ile Phe  Asn Arg Trp Ile Asn  Asn Ala Ser Leu Gln  Pro Thr Leu 
    1010                 1015                 1020             


Ser Ala  Thr Ser Asn Leu Thr  Val Leu Val Pro Ser  Gln Gln Ala 
    1025                 1030                 1035             


Thr Glu  Asp Met Asp Gln Asp  Glu Lys Ser Phe Trp  Leu Ser Gln 
    1040                 1045                 1050             


Ser Asn  Ile Pro Ala Leu Ile  Lys Tyr His Met Leu  Leu Gly Thr 
    1055                 1060                 1065             


Tyr Arg  Val Ala Asp Leu Gln  Thr Leu Ser Ser Ser  Asp Met Leu 
    1070                 1075                 1080             


Ala Thr  Ser Leu Gln Gly Asn  Phe Leu His Leu Ala  Lys Val Asp 
    1085                 1090                 1095             


Gly Asn  Ile Thr Ile Glu Gly  Ala Ser Ile Val Asp  Gly Asp Asn 
    1100                 1105                 1110             


Ala Ala  Thr Asn Gly Val Ile  His Ile Ile Asn Lys  Val Leu Val 
    1115                 1120                 1125             


Pro Gln  Arg Arg Leu Thr Gly  Ser Leu Pro Asn Leu  Leu Met Arg 
    1130                 1135                 1140             


Leu Glu  Gln Met Pro Asp Tyr  Ser Ile Phe Arg Gly  Tyr Ile Ile 
    1145                 1150                 1155             


Gln Tyr  Asn Leu Ala Asn Ala  Ile Glu Ala Ala Asp  Ala Tyr Thr 
    1160                 1165                 1170             


Val Phe  Ala Pro Asn Asn Asn  Ala Ile Glu Asn Tyr  Ile Arg Glu 
    1175                 1180                 1185             


Lys Lys  Val Leu Ser Leu Glu  Glu Asp Val Leu Arg  Tyr His Val 
    1190                 1195                 1200             


Val Leu  Glu Glu Lys Leu Leu  Lys Asn Asp Leu His  Asn Gly Met 
    1205                 1210                 1215             


His Arg  Glu Thr Met Leu Gly  Phe Ser Tyr Phe Leu  Ser Phe Phe 
    1220                 1225                 1230             


Leu His  Asn Asp Gln Leu Tyr  Val Asn Glu Ala Pro  Ile Asn Tyr 
    1235                 1240                 1245             


Thr Asn  Val Ala Thr Asp Lys  Gly Val Ile His Gly  Leu Gly Lys 
    1250                 1255                 1260             


Val Leu  Glu Ile Gln Lys Asn  Arg Cys Asp Asn Asn  Asp Thr Thr 
    1265                 1270                 1275             


Ile Ile  Arg Gly Arg Cys Arg  Thr Cys Ser Ser Glu  Leu Thr Cys 
    1280                 1285                 1290             


Pro Phe  Gly Thr Lys Ser Leu  Gly Asn Glu Lys Arg  Arg Cys Ile 
    1295                 1300                 1305             


Tyr Thr  Ser Tyr Phe Met Gly  Arg Arg Thr Leu Phe  Ile Gly Cys 
    1310                 1315                 1320             


Gln Pro  Lys Cys Val Arg Thr  Val Ile Thr Arg Glu  Cys Cys Ala 
    1325                 1330                 1335             


Gly Phe  Phe Gly Pro Gln Cys  Gln Pro Cys Pro Gly  Asn Ala Gln 
    1340                 1345                 1350             


Asn Val  Cys Phe Gly Asn Gly  Ile Cys Leu Asp Gly  Val Asn Gly 
    1355                 1360                 1365             


Thr Gly  Val Cys Glu Cys Gly  Glu Gly Phe Ser Gly  Thr Ala Cys 
    1370                 1375                 1380             


Glu Thr  Cys Thr Glu Gly Lys  Tyr Gly Ile His Cys  Asp Gln Ala 
    1385                 1390                 1395             


Cys Ser  Cys Val His Gly Arg  Cys Asn Gln Gly Pro  Leu Gly Asp 
    1400                 1405                 1410             


Gly Ser  Cys Asp Cys Asp Val  Gly Trp Arg Gly Val  His Cys Asp 
    1415                 1420                 1425             


Asn Ala  Thr Thr Glu Asp Asn  Cys Asn Gly Thr Cys  His Thr Ser 
    1430                 1435                 1440             


Ala Asn  Cys Leu Thr Asn Ser  Asp Gly Thr Ala Ser  Cys Lys Cys 
    1445                 1450                 1455             


Ala Ala  Gly Phe Gln Gly Asn  Gly Thr Ile Cys Thr  Ala Ile Asn 
    1460                 1465                 1470             


Ala Cys  Glu Ile Ser Asn Gly  Gly Cys Ser Ala Lys  Ala Asp Cys 
    1475                 1480                 1485             


Lys Arg  Thr Thr Pro Gly Arg  Arg Val Cys Thr Cys  Lys Ala Gly 
    1490                 1495                 1500             


Tyr Thr  Gly Asp Gly Ile Val  Cys Leu Glu Ile Asn  Pro Cys Leu 
    1505                 1510                 1515             


Glu Asn  His Gly Gly Cys Asp  Lys Asn Ala Glu Cys  Thr Gln Thr 
    1520                 1525                 1530             


Gly Pro  Asn Gln Ala Ala Cys  Asn Cys Leu Pro Ala  Tyr Thr Gly 
    1535                 1540                 1545             


Asp Gly  Lys Val Cys Thr Leu  Ile Asn Val Cys Leu  Thr Lys Asn 
    1550                 1555                 1560             


Gly Gly  Cys Ser Glu Phe Ala  Ile Cys Asn His Thr  Gly Gln Val 
    1565                 1570                 1575             


Glu Arg  Thr Cys Thr Cys Lys  Pro Asn Tyr Ile Gly  Asp Gly Phe 
    1580                 1585                 1590             


Thr Cys  Arg Gly Ser Ile Tyr  Gln Glu Leu Pro Lys  Asn Pro Lys 
    1595                 1600                 1605             


Thr Ser  Gln Tyr Phe Phe Gln  Leu Gln Glu His Phe  Val Lys Asp 
    1610                 1615                 1620             


Leu Val  Gly Pro Gly Pro Phe  Thr Val Phe Ala Pro  Leu Ser Ala 
    1625                 1630                 1635             


Ala Phe  Asp Glu Glu Ala Arg  Val Lys Asp Trp Asp  Lys Tyr Gly 
    1640                 1645                 1650             


Leu Met  Pro Gln Val Leu Arg  Tyr His Val Val Ala  Cys His Gln 
    1655                 1660                 1665             


Leu Leu  Leu Glu Asn Leu Lys  Leu Ile Ser Asn Ala  Thr Ser Leu 
    1670                 1675                 1680             


Gln Gly  Glu Pro Ile Val Ile  Ser Val Ser Gln Ser  Thr Val Tyr 
    1685                 1690                 1695             


Ile Asn  Asn Lys Ala Lys Ile  Ile Ser Ser Asp Ile  Ile Ser Thr 
    1700                 1705                 1710             


Asn Gly  Ile Val His Ile Ile  Asp Lys Leu Leu Ser  Pro Lys Asn 
    1715                 1720                 1725             


Leu Leu  Ile Thr Pro Lys Asp  Asn Ser Gly Arg Ile  Leu Gln Asn 
    1730                 1735                 1740             


Leu Thr  Thr Leu Ala Thr Asn  Asn Gly Tyr Ile Lys  Phe Ser Asn 
    1745                 1750                 1755             


Leu Ile  Gln Asp Ser Gly Leu  Leu Ser Val Ile Thr  Asp Pro Ile 
    1760                 1765                 1770             


His Thr  Pro Val Thr Leu Phe  Trp Pro Thr Asp Gln  Ala Leu His 
    1775                 1780                 1785             


Ala Leu  Pro Ala Glu Gln Gln  Asp Phe Leu Phe Asn  Gln Asp Asn 
    1790                 1795                 1800             


Lys Asp  Lys Leu Lys Glu Tyr  Leu Lys Phe His Val  Ile Arg Asp 
    1805                 1810                 1815             


Ala Lys  Val Leu Ala Val Asp  Leu Pro Thr Ser Thr  Ala Trp Lys 
    1820                 1825                 1830             


Thr Leu  Gln Gly Ser Glu Leu  Ser Val Lys Cys Gly  Ala Gly Arg 
    1835                 1840                 1845             


Asp Ile  Gly Asp Leu Phe Leu  Asn Gly Gln Thr Cys  Arg Ile Val 
    1850                 1855                 1860             


Gln Arg  Glu Leu Leu Phe Asp  Leu Gly Val Ala Tyr  Gly Ile Asp 
    1865                 1870                 1875             


Cys Leu  Leu Ile Asp Pro Thr  Leu Gly Gly Arg Cys  Asp Thr Phe 
    1880                 1885                 1890             


Thr Thr  Phe Asp Ala Ser Gly  Glu Cys Gly Ser Cys  Val Asn Thr 
    1895                 1900                 1905             


Pro Ser  Cys Pro Arg Trp Ser  Lys Pro Lys Gly Val  Lys Gln Lys 
    1910                 1915                 1920             


Cys Leu  Tyr Asn Leu Pro Phe  Lys Arg Asn Leu Glu  Gly Cys Arg 
    1925                 1930                 1935             


Glu Arg  Cys Ser Leu Val Ile  Gln Ile Pro Arg Cys  Cys Lys Gly 
    1940                 1945                 1950             


Tyr Phe  Gly Arg Asp Cys Gln  Ala Cys Pro Gly Gly  Pro Asp Ala 
    1955                 1960                 1965             


Pro Cys  Asn Asn Arg Gly Val  Cys Leu Asp Gln Tyr  Ser Ala Thr 
    1970                 1975                 1980             


Gly Glu  Cys Lys Cys Asn Thr  Gly Phe Asn Gly Thr  Ala Cys Glu 
    1985                 1990                 1995             


Met Cys  Trp Pro Gly Arg Phe  Gly Pro Asp Cys Leu  Pro Cys Gly 
    2000                 2005                 2010             


Cys Ser  Asp His Gly Gln Cys  Asp Asp Gly Ile Thr  Gly Ser Gly 
    2015                 2020                 2025             


Gln Cys  Leu Cys Glu Thr Gly  Trp Thr Gly Pro Ser  Cys Asp Thr 
    2030                 2035                 2040             


Gln Ala  Val Leu Pro Ala Val  Cys Thr Pro Pro Cys  Ser Ala His 
    2045                 2050                 2055             


Ala Thr  Cys Lys Glu Asn Asn  Thr Cys Glu Cys Asn  Leu Asp Tyr 
    2060                 2065                 2070             


Glu Gly  Asp Gly Ile Thr Cys  Thr Val Val Asp Phe  Cys Lys Gln 
    2075                 2080                 2085             


Asp Asn  Gly Gly Cys Ala Lys  Val Ala Arg Cys Ser  Gln Lys Gly 
    2090                 2095                 2100             


Thr Lys  Val Ser Cys Ser Cys  Gln Lys Gly Tyr Lys  Gly Asp Gly 
    2105                 2110                 2115             


His Ser  Cys Thr Glu Ile Asp  Pro Cys Ala Asp Gly  Leu Asn Gly 
    2120                 2125                 2130             


Gly Cys  His Glu His Ala Thr  Cys Lys Met Thr Gly  Pro Gly Lys 
    2135                 2140                 2145             


His Lys  Cys Glu Cys Lys Ser  His Tyr Val Gly Asp  Gly Leu Asn 
    2150                 2155                 2160             


Cys Glu  Pro Glu Gln Leu Pro  Ile Asp Arg Cys Leu  Gln Asp Asn 
    2165                 2170                 2175             


Gly Gln  Cys His Ala Asp Ala  Lys Cys Val Asp Leu  His Phe Gln 
    2180                 2185                 2190             


Asp Thr  Thr Val Gly Val Phe  His Leu Arg Ser Pro  Leu Gly Gln 
    2195                 2200                 2205             


Tyr Lys  Leu Thr Phe Asp Lys  Ala Arg Glu Ala Cys  Ala Asn Glu 
    2210                 2215                 2220             


Ala Ala  Thr Met Ala Thr Tyr  Asn Gln Leu Ser Tyr  Ala Gln Lys 
    2225                 2230                 2235             


Ala Lys  Tyr His Leu Cys Ser  Ala Gly Trp Leu Glu  Thr Gly Arg 
    2240                 2245                 2250             


Val Ala  Tyr Pro Thr Ala Phe  Ala Ser Gln Asn Cys  Gly Ser Gly 
    2255                 2260                 2265             


Val Val  Gly Ile Val Asp Tyr  Gly Pro Arg Pro Asn  Lys Ser Glu 
    2270                 2275                 2280             


Met Trp  Asp Val Phe Cys Tyr  Arg Met Lys Asp Val  Asn Cys Thr 
    2285                 2290                 2295             


Cys Lys  Val Gly Tyr Val Gly  Asp Gly Phe Ser Cys  Ser Gly Asn 
    2300                 2305                 2310             


Leu Leu  Gln Val Leu Met Ser  Phe Pro Ser Leu Thr  Asn Phe Leu 
    2315                 2320                 2325             


Thr Glu  Val Leu Ala Tyr Ser  Asn Ser Ser Ala Arg  Gly Arg Ala 
    2330                 2335                 2340             


Phe Leu  Glu His Leu Thr Asp  Leu Ser Ile Arg Gly  Thr Leu Phe 
    2345                 2350                 2355             


Val Pro  Gln Asn Ser Gly Leu  Gly Glu Asn Glu Thr  Leu Ser Gly 
    2360                 2365                 2370             


Arg Asp  Ile Glu His His Leu  Ala Asn Val Ser Met  Phe Phe Tyr 
    2375                 2380                 2385             


Asn Asp  Leu Val Asn Gly Thr  Thr Leu Gln Thr Arg  Leu Gly Ser 
    2390                 2395                 2400             


Lys Leu  Leu Ile Thr Ala Ser  Gln Asp Pro Leu Gln  Pro Thr Glu 
    2405                 2410                 2415             


Thr Arg  Phe Val Asp Gly Arg  Ala Ile Leu Gln Trp  Asp Ile Phe 
    2420                 2425                 2430             


Ala Ser  Asn Gly Ile Ile His  Val Ile Ser Arg Pro  Leu Lys Ala 
    2435                 2440                 2445             


Pro Pro  Ala Pro Val Thr Leu  Thr His Thr Gly Leu  Gly Ala Gly 
    2450                 2455                 2460             


Ile Phe  Phe Ala Ile Ile Leu  Val Thr Gly Ala Val  Ala Leu Ala 
    2465                 2470                 2475             


Ala Tyr  Ser Tyr Phe Arg Ile  Asn Arg Arg Thr Ile  Gly Phe Gln 
    2480                 2485                 2490             


His Phe  Glu Ser Glu Glu Asp  Ile Asn Val Ala Ala  Leu Gly Lys 
    2495                 2500                 2505             


Gln Gln  Pro Glu Asn Ile Ser  Asn Pro Leu Tyr Glu  Ser Thr Thr 
    2510                 2515                 2520             


Ser Ala  Pro Pro Glu Pro Ser  Tyr Asp Pro Phe Thr  Asp Ser Glu 
    2525                 2530                 2535             


Glu Arg  Gln Leu Glu Gly Asn  Asp Pro Leu Arg Thr  Leu 
    2540                 2545                 2550     


<210>  39
<211>  2471
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  40
<211>  3623
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ile Phe Ala Glu Val Asn Gly Glu Ala Gly Glu Leu Glu Leu Gln Arg 
            20                  25                  30          


Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg 
        35                  40                  45              


Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg 
    50                  55                  60                  


Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu 
65                  70                  75                  80  


Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys 
                85                  90                  95      


Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln 
            100                 105                 110         


Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln 
        115                 120                 125             


Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly 
    130                 135                 140                 


Gly Thr Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro 
145                 150                 155                 160 


Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile 
                165                 170                 175     


Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn 
            180                 185                 190         


Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro 
        195                 200                 205             


Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg 
    210                 215                 220                 


Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu 
225                 230                 235                 240 


Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Phe Ser Pro Asn 
                245                 250                 255     


Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly 
            260                 265                 270         


Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr 
        275                 280                 285             


Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu 
    290                 295                 300                 


Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro 
305                 310                 315                 320 


Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys 
                325                 330                 335     


Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile 
            340                 345                 350         


Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser 
        355                 360                 365             


Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly 
    370                 375                 380                 


Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu 
385                 390                 395                 400 


Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr 
                405                 410                 415     


Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn 
            420                 425                 430         


Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val 
        435                 440                 445             


Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly 
    450                 455                 460                 


Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly 
465                 470                 475                 480 


Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His 
                485                 490                 495     


Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu 
            500                 505                 510         


Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro 
        515                 520                 525             


His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln 
    530                 535                 540                 


Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser 
545                 550                 555                 560 


Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly 
                565                 570                 575     


Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly 
            580                 585                 590         


Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly 
        595                 600                 605             


Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro 
    610                 615                 620                 


Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His 
625                 630                 635                 640 


Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr 
                645                 650                 655     


Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro 
            660                 665                 670         


Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser 
        675                 680                 685             


Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser 
    690                 695                 700                 


Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe 
705                 710                 715                 720 


Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr 
                725                 730                 735     


Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His 
            740                 745                 750         


Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val 
        755                 760                 765             


Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile 
    770                 775                 780                 


Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile 
785                 790                 795                 800 


Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala 
                805                 810                 815     


Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe 
            820                 825                 830         


Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln 
        835                 840                 845             


Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly 
    850                 855                 860                 


Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser 
865                 870                 875                 880 


Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro 
                885                 890                 895     


Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys 
            900                 905                 910         


Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu 
        915                 920                 925             


Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln 
    930                 935                 940                 


Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp 
945                 950                 955                 960 


His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr 
                965                 970                 975     


Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val 
            980                 985                 990         


Tyr Asp Thr Asp Ser Glu Thr Ser  Leu Gly Arg Tyr Cys  Gly Lys Ser 
        995                 1000                 1005             


Ile Pro  Pro Ser Leu Thr Ser  Ser Gly Asn Ser Leu  Met Leu Val 
    1010                 1015                 1020             


Phe Val  Thr Asp Ser Asp Leu  Ala Tyr Glu Gly Phe  Leu Ile Asn 
    1025                 1030                 1035             


Tyr Glu  Ala Ile Ser Ala Ala  Thr Ala Cys Leu Gln  Asp Tyr Thr 
    1040                 1045                 1050             


Asp Asp  Leu Gly Thr Phe Thr  Ser Pro Asn Phe Pro  Asn Asn Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Trp Glu Cys Ile  Tyr Arg Ile Thr Val  Arg Thr Gly 
    1070                 1075                 1080             


Gln Leu  Ile Ala Val His Phe  Thr Asn Phe Ser Leu  Glu Glu Ala 
    1085                 1090                 1095             


Ile Gly  Asn Tyr Tyr Thr Asp  Phe Leu Glu Ile Arg  Asp Gly Gly 
    1100                 1105                 1110             


Tyr Glu  Lys Ser Pro Leu Leu  Gly Ile Phe Tyr Gly  Ser Asn Leu 
    1115                 1120                 1125             


Pro Pro  Thr Ile Ile Ser His  Ser Asn Lys Leu Trp  Leu Lys Phe 
    1130                 1135                 1140             


Lys Ser  Asp Gln Ile Asp Thr  Arg Ser Gly Phe Ser  Ala Tyr Trp 
    1145                 1150                 1155             


Asp Gly  Ser Ser Thr Gly Cys  Gly Gly Asn Leu Thr  Thr Ser Ser 
    1160                 1165                 1170             


Gly Thr  Phe Ile Ser Pro Asn  Tyr Pro Met Pro Tyr  Tyr His Ser 
    1175                 1180                 1185             


Ser Glu  Cys Tyr Trp Trp Leu  Lys Ser Ser His Gly  Ser Ala Phe 
    1190                 1195                 1200             


Glu Leu  Glu Phe Lys Asp Phe  His Leu Glu His His  Pro Asn Cys 
    1205                 1210                 1215             


Thr Leu  Asp Tyr Leu Ala Val  Tyr Asp Gly Pro Ser  Ser Asn Ser 
    1220                 1225                 1230             


His Leu  Leu Thr Gln Leu Cys  Gly Asp Glu Lys Pro  Pro Leu Ile 
    1235                 1240                 1245             


Arg Ser  Ser Gly Asp Ser Met  Phe Ile Lys Leu Arg  Thr Asp Glu 
    1250                 1255                 1260             


Gly Gln  Gln Gly Arg Gly Phe  Lys Ala Glu Tyr Arg  Gln Thr Cys 
    1265                 1270                 1275             


Glu Asn  Val Val Ile Val Asn  Gln Thr Tyr Gly Ile  Leu Glu Ser 
    1280                 1285                 1290             


Ile Gly  Tyr Pro Asn Pro Tyr  Ser Glu Asn Gln His  Cys Asn Trp 
    1295                 1300                 1305             


Thr Ile  Arg Ala Thr Thr Gly  Asn Thr Val Asn Tyr  Thr Phe Leu 
    1310                 1315                 1320             


Ala Phe  Asp Leu Glu His His  Ile Asn Cys Ser Thr  Asp Tyr Leu 
    1325                 1330                 1335             


Glu Leu  Tyr Asp Gly Pro Arg  Gln Met Gly Arg Tyr  Cys Gly Val 
    1340                 1345                 1350             


Asp Leu  Pro Pro Pro Gly Ser  Thr Thr Ser Ser Lys  Leu Gln Val 
    1355                 1360                 1365             


Leu Leu  Leu Thr Asp Gly Val  Gly Arg Arg Glu Lys  Gly Phe Gln 
    1370                 1375                 1380             


Met Gln  Trp Phe Val Tyr Gly  Cys Gly Gly Glu Leu  Ser Gly Ala 
    1385                 1390                 1395             


Thr Gly  Ser Phe Ser Ser Pro  Gly Phe Pro Asn Arg  Tyr Pro Pro 
    1400                 1405                 1410             


Asn Lys  Glu Cys Ile Trp Tyr  Ile Arg Thr Asp Pro  Gly Ser Ser 
    1415                 1420                 1425             


Ile Gln  Leu Thr Ile His Asp  Phe Asp Val Glu Tyr  His Ser Arg 
    1430                 1435                 1440             


Cys Asn  Phe Asp Val Leu Glu  Ile Tyr Gly Gly Pro  Asp Phe His 
    1445                 1450                 1455             


Ser Pro  Arg Ile Ala Gln Leu  Cys Thr Gln Arg Ser  Pro Glu Asn 
    1460                 1465                 1470             


Pro Met  Gln Val Ser Ser Thr  Gly Asn Glu Leu Ala  Ile Arg Phe 
    1475                 1480                 1485             


Lys Thr  Asp Leu Ser Ile Asn  Gly Arg Gly Phe Asn  Ala Ser Trp 
    1490                 1495                 1500             


Gln Ala  Val Thr Gly Gly Cys  Gly Gly Ile Phe Gln  Ala Pro Ser 
    1505                 1510                 1515             


Gly Glu  Ile His Ser Pro Asn  Tyr Pro Ser Pro Tyr  Arg Ser Asn 
    1520                 1525                 1530             


Thr Asp  Cys Ser Trp Val Ile  Arg Val Asp Arg Asn  His Arg Val 
    1535                 1540                 1545             


Leu Leu  Asn Phe Thr Asp Phe  Asp Leu Glu Pro Gln  Asp Ser Cys 
    1550                 1555                 1560             


Ile Met  Ala Tyr Asp Gly Leu  Ser Ser Thr Met Ser  Arg Leu Ala 
    1565                 1570                 1575             


Arg Thr  Cys Gly Arg Glu Gln  Leu Ala Asn Pro Ile  Val Ser Ser 
    1580                 1585                 1590             


Gly Asn  Ser Leu Phe Leu Arg  Phe Gln Ser Gly Pro  Ser Arg Gln 
    1595                 1600                 1605             


Asn Arg  Gly Phe Arg Ala Gln  Phe Arg Gln Ala Cys  Gly Gly His 
    1610                 1615                 1620             


Ile Leu  Thr Ser Ser Phe Asp  Thr Val Ser Ser Pro  Arg Phe Pro 
    1625                 1630                 1635             


Ala Asn  Tyr Pro Asn Asn Gln  Asn Cys Ser Trp Ile  Ile Gln Ala 
    1640                 1645                 1650             


Gln Pro  Pro Leu Asn His Ile  Thr Leu Ser Phe Thr  His Phe Glu 
    1655                 1660                 1665             


Leu Glu  Arg Ser Thr Thr Cys  Ala Arg Asp Phe Val  Glu Ile Leu 
    1670                 1675                 1680             


Asp Gly  Gly His Glu Asp Ala  Pro Leu Arg Gly Arg  Tyr Cys Gly 
    1685                 1690                 1695             


Thr Asp  Met Pro His Pro Ile  Thr Ser Phe Ser Ser  Ala Leu Thr 
    1700                 1705                 1710             


Leu Arg  Phe Val Ser Asp Ser  Ser Ile Ser Ala Gly  Gly Phe His 
    1715                 1720                 1725             


Thr Thr  Val Thr Ala Ser Val  Ser Ala Cys Gly Gly  Thr Phe Tyr 
    1730                 1735                 1740             


Met Ala  Glu Gly Ile Phe Asn  Ser Pro Gly Tyr Pro  Asp Ile Tyr 
    1745                 1750                 1755             


Pro Pro  Asn Val Glu Cys Val  Trp Asn Ile Val Ser  Ser Pro Gly 
    1760                 1765                 1770             


Asn Arg  Leu Gln Leu Ser Phe  Ile Ser Phe Gln Leu  Glu Asp Ser 
    1775                 1780                 1785             


Gln Asp  Cys Ser Arg Asp Phe  Val Glu Ile Arg Glu  Gly Asn Ala 
    1790                 1795                 1800             


Thr Gly  His Leu Val Gly Arg  Tyr Cys Gly Asn Ser  Phe Pro Leu 
    1805                 1810                 1815             


Asn Tyr  Ser Ser Ile Val Gly  His Thr Leu Trp Val  Arg Phe Ile 
    1820                 1825                 1830             


Ser Asp  Gly Ser Gly Ser Gly  Thr Gly Phe Gln Ala  Thr Phe Met 
    1835                 1840                 1845             


Lys Ile  Phe Gly Asn Asp Asn  Ile Val Gly Thr His  Gly Lys Val 
    1850                 1855                 1860             


Ala Ser  Pro Phe Trp Pro Glu  Asn Tyr Pro His Asn  Ser Asn Tyr 
    1865                 1870                 1875             


Gln Trp  Thr Val Asn Val Asn  Ala Ser His Val Val  His Gly Arg 
    1880                 1885                 1890             


Ile Leu  Glu Met Asp Ile Glu  Glu Ile Gln Asn Cys  Tyr Tyr Asp 
    1895                 1900                 1905             


Lys Leu  Arg Ile Tyr Asp Gly  Pro Ser Ile His Ala  Arg Leu Ile 
    1910                 1915                 1920             


Gly Ala  Tyr Cys Gly Thr Gln  Thr Glu Ser Phe Ser  Ser Thr Gly 
    1925                 1930                 1935             


Asn Ser  Leu Thr Phe His Phe  Tyr Ser Asp Ser Ser  Ile Ser Gly 
    1940                 1945                 1950             


Lys Gly  Phe Leu Leu Glu Trp  Phe Ala Val Asp Ala  Pro Asp Gly 
    1955                 1960                 1965             


Val Leu  Pro Thr Ile Ala Pro  Gly Ala Cys Gly Gly  Phe Leu Arg 
    1970                 1975                 1980             


Thr Gly  Asp Ala Pro Val Phe  Leu Phe Ser Pro Gly  Trp Pro Asp 
    1985                 1990                 1995             


Ser Tyr  Ser Asn Arg Val Asp  Cys Thr Trp Leu Ile  Gln Ala Pro 
    2000                 2005                 2010             


Asp Ser  Thr Val Glu Leu Asn  Ile Leu Ser Leu Asp  Ile Glu Ser 
    2015                 2020                 2025             


His Arg  Thr Cys Ala Tyr Asp  Ser Leu Val Ile Arg  Asp Gly Asp 
    2030                 2035                 2040             


Asn Asn  Leu Ala Gln Gln Leu  Ala Val Leu Cys Gly  Arg Glu Ile 
    2045                 2050                 2055             


Pro Gly  Pro Ile Arg Ser Thr  Gly Glu Tyr Met Phe  Ile Arg Phe 
    2060                 2065                 2070             


Thr Ser  Asp Ser Ser Val Thr  Arg Ala Gly Phe Asn  Ala Ser Phe 
    2075                 2080                 2085             


His Lys  Ser Cys Gly Gly Tyr  Leu His Ala Asp Arg  Gly Ile Ile 
    2090                 2095                 2100             


Thr Ser  Pro Lys Tyr Pro Glu  Thr Tyr Pro Ser Asn  Leu Asn Cys 
    2105                 2110                 2115             


Ser Trp  His Val Leu Val Gln  Ser Gly Leu Thr Ile  Ala Val His 
    2120                 2125                 2130             


Phe Glu  Gln Pro Phe Gln Ile  Pro Asn Gly Asp Ser  Ser Cys Asn 
    2135                 2140                 2145             


Gln Gly  Asp Tyr Leu Val Leu  Arg Asn Gly Pro Asp  Ile Cys Ser 
    2150                 2155                 2160             


Pro Pro  Leu Gly Pro Pro Gly  Gly Asn Gly His Phe  Cys Gly Ser 
    2165                 2170                 2175             


His Ala  Ser Ser Thr Leu Phe  Thr Ser Asp Asn Gln  Met Phe Val 
    2180                 2185                 2190             


Gln Phe  Ile Ser Asp His Ser  Asn Glu Gly Gln Gly  Phe Lys Ile 
    2195                 2200                 2205             


Lys Tyr  Glu Ala Lys Ser Leu  Ala Cys Gly Gly Asn  Val Tyr Ile 
    2210                 2215                 2220             


His Asp  Ala Asp Ser Ala Gly  Tyr Val Thr Ser Pro  Asn His Pro 
    2225                 2230                 2235             


His Asn  Tyr Pro Pro His Ala  Asp Cys Ile Trp Ile  Leu Ala Ala 
    2240                 2245                 2250             


Pro Pro  Glu Thr Arg Ile Gln  Leu Gln Phe Glu Asp  Arg Phe Asp 
    2255                 2260                 2265             


Ile Glu  Val Thr Pro Asn Cys  Thr Ser Asn Tyr Leu  Glu Leu Arg 
    2270                 2275                 2280             


Asp Gly  Val Asp Ser Asp Ala  Pro Ile Leu Ser Lys  Phe Cys Gly 
    2285                 2290                 2295             


Thr Ser  Leu Pro Ser Ser Gln  Trp Ser Ser Gly Glu  Val Met Tyr 
    2300                 2305                 2310             


Leu Arg  Phe Arg Ser Asp Asn  Ser Pro Thr His Val  Gly Phe Lys 
    2315                 2320                 2325             


Ala Lys  Tyr Ser Ile Ala Gln  Cys Gly Gly Arg Val  Pro Gly Gln 
    2330                 2335                 2340             


Ser Gly  Val Val Glu Ser Ile  Gly His Pro Thr Leu  Pro Tyr Arg 
    2345                 2350                 2355             


Asp Asn  Leu Phe Cys Glu Trp  His Leu Gln Gly Leu  Ser Gly His 
    2360                 2365                 2370             


Tyr Leu  Thr Ile Ser Phe Glu  Asp Phe Asn Leu Gln  Asn Ser Ser 
    2375                 2380                 2385             


Gly Cys  Glu Lys Asp Phe Val  Glu Ile Trp Asp Asn  His Thr Ser 
    2390                 2395                 2400             


Gly Asn  Ile Leu Gly Arg Tyr  Cys Gly Asn Thr Ile  Pro Asp Ser 
    2405                 2410                 2415             


Ile Asp  Thr Ser Ser Asn Thr  Ala Val Val Arg Phe  Val Thr Asp 
    2420                 2425                 2430             


Gly Ser  Val Thr Ala Ser Gly  Phe Arg Leu Arg Phe  Glu Ser Ser 
    2435                 2440                 2445             


Met Glu  Glu Cys Gly Gly Asp  Leu Gln Gly Ser Ile  Gly Thr Phe 
    2450                 2455                 2460             


Thr Ser  Pro Asn Tyr Pro Asn  Pro Asn Pro His Gly  Arg Ile Cys 
    2465                 2470                 2475             


Glu Trp  Arg Ile Thr Ala Pro  Glu Gly Arg Arg Ile  Thr Leu Met 
    2480                 2485                 2490             


Phe Asn  Asn Leu Arg Leu Ala  Thr His Pro Ser Cys  Asn Asn Glu 
    2495                 2500                 2505             


His Val  Ile Val Phe Asn Gly  Ile Arg Ser Asn Ser  Pro Gln Leu 
    2510                 2515                 2520             


Glu Lys  Leu Cys Ser Ser Val  Asn Val Ser Asn Glu  Ile Lys Ser 
    2525                 2530                 2535             


Ser Gly  Asn Thr Met Lys Val  Ile Phe Phe Thr Asp  Gly Ser Arg 
    2540                 2545                 2550             


Pro Tyr  Gly Gly Phe Thr Ala  Ser Tyr Thr Ser Ser  Glu Asp Ala 
    2555                 2560                 2565             


Val Cys  Gly Gly Ser Leu Pro  Asn Thr Pro Glu Gly  Asn Phe Thr 
    2570                 2575                 2580             


Ser Pro  Gly Tyr Asp Gly Val  Arg Asn Tyr Ser Arg  Asn Leu Asn 
    2585                 2590                 2595             


Cys Glu  Trp Thr Leu Ser Asn  Pro Asn Gln Gly Asn  Ser Ser Ile 
    2600                 2605                 2610             


Ser Ile  His Phe Glu Asp Phe  Tyr Leu Glu Ser His  Gln Asp Cys 
    2615                 2620                 2625             


Gln Phe  Asp Val Leu Glu Phe  Arg Val Gly Asp Ala  Asp Gly Pro 
    2630                 2635                 2640             


Leu Met  Trp Arg Leu Cys Gly  Pro Ser Lys Pro Thr  Leu Pro Leu 
    2645                 2650                 2655             


Val Ile  Pro Tyr Ser Gln Val  Trp Ile His Phe Val  Thr Asn Glu 
    2660                 2665                 2670             


Arg Val  Glu His Ile Gly Phe  His Ala Lys Tyr Ser  Phe Thr Asp 
    2675                 2680                 2685             


Cys Gly  Gly Ile Gln Ile Gly  Asp Ser Gly Val Ile  Thr Ser Pro 
    2690                 2695                 2700             


Asn Tyr  Pro Asn Ala Tyr Asp  Ser Leu Thr His Cys  Ser Ser Leu 
    2705                 2710                 2715             


Leu Glu  Ala Pro Gln Gly His  Thr Ile Thr Leu Thr  Phe Ser Asp 
    2720                 2725                 2730             


Phe Asp  Ile Glu Pro His Thr  Thr Cys Ala Trp Asp  Ser Val Thr 
    2735                 2740                 2745             


Val Arg  Asn Gly Gly Ser Pro  Glu Ser Pro Ile Ile  Gly Gln Tyr 
    2750                 2755                 2760             


Cys Gly  Asn Ser Asn Pro Arg  Thr Ile Gln Ser Gly  Ser Asn Gln 
    2765                 2770                 2775             


Leu Val  Val Thr Phe Asn Ser  Asp His Ser Leu Gln  Gly Gly Gly 
    2780                 2785                 2790             


Phe Tyr  Ala Thr Trp Asn Thr  Gln Thr Leu Gly Cys  Gly Gly Ile 
    2795                 2800                 2805             


Phe His  Ser Asp Asn Gly Thr  Ile Arg Ser Pro His  Trp Pro Gln 
    2810                 2815                 2820             


Asn Phe  Pro Glu Asn Ser Arg  Cys Ser Trp Thr Ala  Ile Thr His 
    2825                 2830                 2835             


Lys Ser  Lys His Leu Glu Ile  Ser Phe Asp Asn Asn  Phe Leu Ile 
    2840                 2845                 2850             


Pro Ser  Gly Asp Gly Gln Cys  Gln Asn Ser Phe Val  Lys Val Trp 
    2855                 2860                 2865             


Ala Gly  Thr Glu Glu Val Asp  Lys Ala Leu Leu Ala  Thr Gly Cys 
    2870                 2875                 2880             


Gly Asn  Val Ala Pro Gly Pro  Val Ile Thr Pro Ser  Asn Thr Phe 
    2885                 2890                 2895             


Thr Ala  Val Phe Gln Ser Gln  Glu Ala Pro Ala Gln  Gly Phe Ser 
    2900                 2905                 2910             


Ala Ser  Phe Val Ser Arg Cys  Gly Ser Asn Phe Thr  Gly Pro Ser 
    2915                 2920                 2925             


Gly Tyr  Ile Ile Ser Pro Asn  Tyr Pro Lys Gln Tyr  Asp Asn Asn 
    2930                 2935                 2940             


Met Asn  Cys Thr Tyr Val Ile  Glu Ala Asn Pro Leu  Ser Val Val 
    2945                 2950                 2955             


Leu Leu  Thr Phe Val Ser Phe  His Leu Glu Ala Arg  Ser Ala Val 
    2960                 2965                 2970             


Thr Gly  Ser Cys Val Asn Asp  Gly Val His Ile Ile  Arg Gly Tyr 
    2975                 2980                 2985             


Ser Val  Met Ser Thr Pro Phe  Ala Thr Val Cys Gly  Asp Glu Met 
    2990                 2995                 3000             


Pro Ala  Pro Leu Thr Ile Ala  Gly Pro Val Leu Leu  Asn Phe Tyr 
    3005                 3010                 3015             


Ser Asn  Glu Gln Ile Thr Asp  Phe Gly Phe Lys Phe  Ser Tyr Arg 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Gly Val  Phe Asn Phe Ser Ser  Gly Ile Ile 
    3035                 3040                 3045             


Thr Ser  Pro Ala Tyr Ser Tyr  Ala Asp Tyr Pro Asn  Asp Met His 
    3050                 3055                 3060             


Cys Leu  Tyr Thr Ile Thr Val  Ser Asp Asp Lys Val  Ile Glu Leu 
    3065                 3070                 3075             


Lys Phe  Ser Asp Phe Asp Val  Val Pro Ser Thr Ser  Cys Ser His 
    3080                 3085                 3090             


Asp Tyr  Leu Ala Ile Tyr Asp  Gly Ala Asn Thr Ser  Asp Pro Leu 
    3095                 3100                 3105             


Leu Gly  Lys Phe Cys Gly Ser  Lys Arg Pro Pro Asn  Val Lys Ser 
    3110                 3115                 3120             


Ser Asn  Asn Ser Met Leu Leu  Val Phe Lys Thr Asp  Ser Phe Gln 
    3125                 3130                 3135             


Thr Ala  Lys Gly Trp Lys Met  Ser Phe Arg Gln Thr  Leu Gly Pro 
    3140                 3145                 3150             


Gln Gln  Gly Cys Gly Gly Tyr  Leu Thr Gly Ser Asn  Asn Thr Phe 
    3155                 3160                 3165             


Ala Ser  Pro Asp Ser Asp Ser  Asn Gly Met Tyr Asp  Lys Asn Leu 
    3170                 3175                 3180             


Asn Cys  Val Trp Ile Ile Ile  Ala Pro Val Asn Lys  Val Ile His 
    3185                 3190                 3195             


Leu Thr  Phe Asn Thr Phe Ala  Leu Glu Ala Ala Ser  Thr Arg Gln 
    3200                 3205                 3210             


Arg Cys  Leu Tyr Asp Tyr Val  Lys Leu Tyr Asp Gly  Asp Ser Glu 
    3215                 3220                 3225             


Asn Ala  Asn Leu Ala Gly Thr  Phe Cys Gly Ser Thr  Val Pro Ala 
    3230                 3235                 3240             


Pro Phe  Ile Ser Ser Gly Asn  Phe Leu Thr Val Gln  Phe Ile Ser 
    3245                 3250                 3255             


Asp Leu  Thr Leu Glu Arg Glu  Gly Phe Asn Ala Thr  Tyr Thr Ile 
    3260                 3265                 3270             


Met Asp  Met Pro Cys Gly Gly  Thr Tyr Asn Ala Thr  Trp Thr Pro 
    3275                 3280                 3285             


Gln Asn  Ile Ser Ser Pro Asn  Ser Ser Asp Pro Asp  Val Pro Phe 
    3290                 3295                 3300             


Ser Ile  Cys Thr Trp Val Ile  Asp Ser Pro Pro His  Gln Gln Val 
    3305                 3310                 3315             


Lys Ile  Thr Val Trp Ala Leu  Gln Leu Thr Ser Gln  Asp Cys Thr 
    3320                 3325                 3330             


Gln Asn  Tyr Leu Gln Leu Gln  Asp Ser Pro Gln Gly  His Gly Asn 
    3335                 3340                 3345             


Ser Arg  Phe Gln Phe Cys Gly  Arg Asn Ala Ser Ala  Val Pro Val 
    3350                 3355                 3360             


Phe Tyr  Ser Ser Met Ser Thr  Ala Met Val Ile Phe  Lys Ser Gly 
    3365                 3370                 3375             


Val Val  Asn Arg Asn Ser Arg  Met Ser Phe Thr Tyr  Gln Ile Ala 
    3380                 3385                 3390             


Asp Cys  Asn Arg Asp Tyr His  Lys Ala Phe Gly Asn  Leu Arg Ser 
    3395                 3400                 3405             


Pro Gly  Trp Pro Asp Asn Tyr  Asp Asn Asp Lys Asp  Cys Thr Val 
    3410                 3415                 3420             


Thr Leu  Thr Ala Pro Gln Asn  His Thr Ile Ser Leu  Phe Phe His 
    3425                 3430                 3435             


Ser Leu  Gly Ile Glu Asn Ser  Val Glu Cys Arg Asn  Asp Phe Leu 
    3440                 3445                 3450             


Glu Val  Arg Asn Gly Ser Asn  Ser Asn Ser Pro Leu  Leu Gly Lys 
    3455                 3460                 3465             


Tyr Cys  Gly Thr Leu Leu Pro  Asn Pro Val Phe Ser  Gln Asn Asn 
    3470                 3475                 3480             


Glu Leu  Tyr Leu Arg Phe Lys  Ser Asp Ser Val Thr  Ser Asp Arg 
    3485                 3490                 3495             


Gly Tyr  Glu Ile Ile Trp Thr  Ser Ser Pro Ser Gly  Cys Gly Gly 
    3500                 3505                 3510             


Thr Leu  Tyr Gly Asp Arg Gly  Ser Phe Thr Ser Pro  Gly Tyr Pro 
    3515                 3520                 3525             


Gly Thr  Tyr Pro Asn Asn Thr  Tyr Cys Glu Trp Val  Leu Val Ala 
    3530                 3535                 3540             


Pro Ala  Gly Arg Leu Val Thr  Ile Asn Phe Tyr Phe  Ile Ser Ile 
    3545                 3550                 3555             


Asp Asp  Pro Gly Asp Cys Val  Gln Asn Tyr Leu Thr  Leu Tyr Asp 
    3560                 3565                 3570             


Gly Pro  Asn Ala Ser Ser Pro  Ser Ser Gly Pro Tyr  Cys Gly Gly 
    3575                 3580                 3585             


Asp Thr  Ser Ile Ala Pro Phe  Val Ala Ser Ser Asn  Gln Val Phe 
    3590                 3595                 3600             


Ile Lys  Phe His Ala Asp Tyr  Ala Arg Arg Pro Ser  Ala Phe Arg 
    3605                 3610                 3615             


Leu Thr  Trp Asp Ser 
    3620             


<210>  41
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gln Pro Arg Arg Ala Gln Ala Pro Gly Ala Gln Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Leu Leu Leu Leu Leu Leu Gly Ala Gly Pro Arg Gly Ser Ser 
            20                  25                  30          


Leu Ala Asn Pro Val Pro Ala Ala Pro Leu Ser Ala Pro Gly Pro Cys 
        35                  40                  45              


Ala Ala Gln Pro Cys Arg Asn Gly Gly Val Cys Thr Ser Arg Pro Glu 
    50                  55                  60                  


Pro Asp Pro Gln His Pro Ala Pro Ala Gly Glu Pro Gly Tyr Ser Cys 
65                  70                  75                  80  


Thr Cys Pro Ala Gly Ile Ser Gly Ala Asn Cys Gln Leu Val Ala Asp 
                85                  90                  95      


Pro Cys Ala Ser Asn Pro Cys His His Gly Asn Cys Ser Ser Ser Ser 
            100                 105                 110         


Ser Ser Ser Ser Asp Gly Tyr Leu Cys Ile Cys Asn Glu Gly Tyr Glu 
        115                 120                 125             


Gly Pro Asn Cys Glu Gln Ala Leu Pro Ser Leu Pro Ala Thr Gly Trp 
    130                 135                 140                 


Thr Glu Ser Met Ala Pro Arg Gln Leu Gln Pro Val Pro Ala Thr Gln 
145                 150                 155                 160 


Glu Pro Asp Lys Ile Leu Pro Arg Ser Gln Ala Thr Val Thr Leu Pro 
                165                 170                 175     


Thr Trp Gln Pro Lys Thr Gly Gln Lys Val Val Glu Met Lys Trp Asp 
            180                 185                 190         


Gln Val Glu Val Ile Pro Asp Ile Ala Cys Gly Asn Ala Ser Ser Asn 
        195                 200                 205             


Ser Ser Ala Gly Gly Arg Leu Val Ser Phe Glu Val Pro Gln Asn Thr 
    210                 215                 220                 


Ser Val Lys Ile Arg Gln Asp Ala Thr Ala Ser Leu Ile Leu Leu Trp 
225                 230                 235                 240 


Lys Val Thr Ala Thr Gly Phe Gln Gln Cys Ser Leu Ile Asp Gly Arg 
                245                 250                 255     


Ser Val Thr Pro Leu Gln Ala Ser Gly Gly Leu Val Leu Leu Glu Glu 
            260                 265                 270         


Met Leu Ala Leu Gly Asn Asn His Phe Ile Gly Phe Val Asn Asp Ser 
        275                 280                 285             


Val Thr Lys Ser Ile Val Ala Leu Arg Leu Thr Leu Val Val Lys Val 
    290                 295                 300                 


Ser Thr Cys Val Pro Gly Glu Ser His Ala Asn Asp Leu Glu Cys Ser 
305                 310                 315                 320 


Gly Lys Gly Lys Cys Thr Thr Lys Pro Ser Glu Ala Thr Phe Ser Cys 
                325                 330                 335     


Thr Cys Glu Glu Gln Tyr Val Gly Thr Phe Cys Glu Glu Tyr Asp Ala 
            340                 345                 350         


Cys Gln Arg Lys Pro Cys Gln Asn Asn Ala Ser Cys Ile Asp Ala Asn 
        355                 360                 365             


Glu Lys Gln Asp Gly Ser Asn Phe Thr Cys Val Cys Leu Pro Gly Tyr 
    370                 375                 380                 


Thr Gly Glu Leu Cys Gln Ser Lys Ile Asp Tyr Cys Ile Leu Asp Pro 
385                 390                 395                 400 


Cys Arg Asn Gly Ala Thr Cys Ile Ser Ser Leu Ser Gly Phe Thr Cys 
                405                 410                 415     


Gln Cys Pro Glu Gly Tyr Phe Gly Ser Ala Cys Glu Glu Lys Val Asp 
            420                 425                 430         


Pro Cys Ala Ser Ser Pro Cys Gln Asn Asn Gly Thr Cys Tyr Val Asp 
        435                 440                 445             


Gly Val His Phe Thr Cys Asn Cys Ser Pro Gly Phe Thr Gly Pro Thr 
    450                 455                 460                 


Cys Ala Gln Leu Ile Asp Phe Cys Ala Leu Ser Pro Cys Ala His Gly 
465                 470                 475                 480 


Thr Cys Arg Ser Val Gly Thr Ser Tyr Lys Cys Leu Cys Asp Pro Gly 
                485                 490                 495     


Tyr His Gly Leu Tyr Cys Glu Glu Glu Tyr Asn Glu Cys Leu Ser Ala 
            500                 505                 510         


Pro Cys Leu Asn Ala Ala Thr Cys Arg Asp Leu Val Asn Gly Tyr Glu 
        515                 520                 525             


Cys Val Cys Leu Ala Glu Tyr Lys Gly Thr His Cys Glu Leu Tyr Lys 
    530                 535                 540                 


Asp Pro Cys Ala Asn Val Ser Cys Leu Asn Gly Ala Thr Cys Asp Ser 
545                 550                 555                 560 


Asp Gly Leu Asn Gly Thr Cys Ile Cys Ala Pro Gly Phe Thr Gly Glu 
                565                 570                 575     


Glu Cys Asp Ile Asp Ile Asn Glu Cys Asp Ser Asn Pro Cys His His 
            580                 585                 590         


Gly Gly Ser Cys Leu Asp Gln Pro Asn Gly Tyr Asn Cys His Cys Pro 
        595                 600                 605             


His Gly Trp Val Gly Ala Asn Cys Glu Ile His Leu Gln Trp Lys Ser 
    610                 615                 620                 


Gly His Met Ala Glu Ser Leu Thr Asn Met Pro Arg His Ser Leu Tyr 
625                 630                 635                 640 


Ile Ile Ile Gly Ala Leu Cys Val Ala Phe Ile Leu Met Leu Ile Ile 
                645                 650                 655     


Leu Ile Val Gly Ile Cys Arg Ile Ser Arg Ile Glu Tyr Gln Gly Ser 
            660                 665                 670         


Ser Arg Pro Ala Tyr Glu Glu Phe Tyr Asn Cys Arg Ser Ile Asp Ser 
        675                 680                 685             


Glu Phe Ser Asn Ala Ile Ala Ser Ile Arg His Ala Arg Phe Gly Lys 
    690                 695                 700                 


Lys Ser Arg Pro Ala Met Tyr Asp Val Ser Pro Ile Ala Tyr Glu Asp 
705                 710                 715                 720 


Tyr Ser Pro Asp Asp Lys Pro Leu Val Thr Leu Ile Lys Thr Lys Asp 
                725                 730                 735     


Leu 
    


<210>  42
<211>  1218
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210>  43
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gly Val Pro Ala Phe Phe Arg Trp Leu Ser Arg Lys Tyr Pro Ser 
1               5                   10                  15      


Ile Ile Val Asn Cys Val Glu Glu Lys Pro Lys Glu Cys Asn Gly Val 
            20                  25                  30          


Lys Ile Pro Val Asp Ala Ser Lys Pro Asn Pro Asn Asp Val Glu Phe 
        35                  40                  45              


Asp Asn Leu Tyr Leu Asp Met Asn Gly Ile Ile His Pro Cys Thr His 
    50                  55                  60                  


Pro Glu Asp Lys Pro Ala Pro Lys Asn Glu Asp Glu Met Met Val Ala 
65                  70                  75                  80  


Ile Phe Glu Tyr Ile Asp Arg Leu Phe Ser Ile Val Arg Pro Arg Arg 
                85                  90                  95      


Leu Leu Tyr Met Ala Ile Asp Gly Val Ala Pro Arg Ala Lys Met Asn 
            100                 105                 110         


Gln Gln Arg Ser Arg Arg Phe Arg Ala Ser Lys Glu Gly Met Glu Ala 
        115                 120                 125             


Ala Val Glu Lys Gln Arg Val Arg Glu Glu Ile Leu Ala Lys Gly Gly 
    130                 135                 140                 


Phe Leu Pro Pro Glu Glu Ile Lys Glu Arg Phe Asp Ser Asn Cys Ile 
145                 150                 155                 160 


Thr Pro Gly Thr Glu Phe Met Asp Asn Leu Ala Lys Cys Leu Arg Tyr 
                165                 170                 175     


Tyr Ile Ala Asp Arg Leu Asn Asn Asp Pro Gly Trp Lys Asn Leu Thr 
            180                 185                 190         


Val Ile Leu Ser Asp Ala Ser Ala Pro Gly Glu Gly Glu His Lys Ile 
        195                 200                 205             


Met Asp Tyr Ile Arg Arg Gln Arg Ala Gln Pro Asn His Asp Pro Asn 
    210                 215                 220                 


Thr His His Cys Leu Cys Gly Ala Asp Ala Asp Leu Ile Met Leu Gly 
225                 230                 235                 240 


Leu Ala Thr His Glu Pro Asn Phe Thr Ile Ile Arg Glu Glu Phe Lys 
                245                 250                 255     


Pro Asn Lys Pro Lys Pro Cys Gly Leu Cys Asn Gln Phe Gly His Glu 
            260                 265                 270         


Val Lys Asp Cys Glu Gly Leu Pro Arg Glu Lys Lys Gly Lys His Asp 
        275                 280                 285             


Glu Leu Ala Asp Ser Leu Pro Cys Ala Glu Gly Glu Phe Ile Phe Leu 
    290                 295                 300                 


Arg Leu Asn Val Leu Arg Glu Tyr Leu Glu Arg Glu Leu Thr Met Ala 
305                 310                 315                 320 


Ser Leu Pro Phe Thr Phe Asp Val Glu Arg Ser Ile Asp Asp Trp Val 
                325                 330                 335     


Phe Met Cys Phe Phe Val Gly Asn Asp Phe Leu Pro His Leu Pro Ser 
            340                 345                 350         


Leu Glu Ile Arg Glu Asn Ala Ile Asp Arg Leu Val Asn Ile Tyr Lys 
        355                 360                 365             


Asn Val Val His Lys Thr Gly Gly Tyr Leu Thr Glu Ser Gly Tyr Val 
    370                 375                 380                 


Asn Leu Gln Arg Val Gln Met Ile Met Leu Ala Val Gly Glu Val Glu 
385                 390                 395                 400 


Asp Ser Ile Phe Lys Lys Arg Lys Asp Asp Glu Asp Ser Phe Arg Arg 
                405                 410                 415     


Arg Gln Lys Glu Lys Arg Lys Arg Met Lys Arg Asp Gln Pro Ala Phe 
            420                 425                 430         


Thr Pro Ser Gly Ile Leu Thr Pro His Ala Leu Gly Ser Arg Asn Ser 
        435                 440                 445             


Pro Gly Ser Gln Val Ala Ser Asn Pro Arg Gln Ala Ala Tyr Glu Met 
    450                 455                 460                 


Arg Met Gln Asn Asn Ser Ser Pro Ser Ile Ser Pro Asn Thr Ser Phe 
465                 470                 475                 480 


Thr Ser Asp Gly Ser Pro Ser Pro Leu Gly Gly Ile Lys Arg Lys Ala 
                485                 490                 495     


Glu Asp Ser Asp Ser Glu Pro Glu Pro Glu Asp Asn Val Arg Leu Trp 
            500                 505                 510         


Glu Ala Gly Trp Lys Gln Arg Tyr Tyr Lys Asn Lys Phe Asp Val Asp 
        515                 520                 525             


Ala Ala Asp Glu Lys Phe Arg Arg Lys Val Val Gln Ser Tyr Val Glu 
    530                 535                 540                 


Gly Leu Cys Trp Val Leu Arg Tyr Tyr Tyr Gln Gly Cys Ala Ser Trp 
545                 550                 555                 560 


Lys Trp Tyr Tyr Pro Phe His Tyr Ala Pro Phe Ala Ser Asp Phe Glu 
                565                 570                 575     


Gly Ile Ala Asp Met Pro Ser Asp Phe Glu Lys Gly Thr Lys Pro Phe 
            580                 585                 590         


Lys Pro Leu Glu Gln Leu Met Gly Val Phe Pro Ala Ala Ser Gly Asn 
        595                 600                 605             


Phe Leu Pro Pro Ser Trp Arg Lys Leu Met Ser Asp Pro Asp Ser Ser 
    610                 615                 620                 


Ile Ile Asp Phe Tyr Pro Glu Asp Phe Ala Ile Asp Leu Asn Gly Lys 
625                 630                 635                 640 


Lys Tyr Ala Trp Gln Gly Val Ala Leu Leu Pro Phe Val Asp Glu Arg 
                645                 650                 655     


Arg Leu Arg Ala Ala Leu Glu Glu Val Tyr Pro Asp Leu Thr Pro Glu 
            660                 665                 670         


Glu Thr Arg Arg Asn Ser Leu Gly Gly Asp Val Leu Phe Val Gly Lys 
        675                 680                 685             


His His Pro Leu His Asp Phe Ile Leu Glu Leu Tyr Gln Thr Gly Ser 
    690                 695                 700                 


Thr Glu Pro Val Glu Val Pro Pro Glu Leu Cys His Gly Ile Gln Gly 
705                 710                 715                 720 


Lys Phe Ser Leu Asp Glu Glu Ala Ile Leu Pro Asp Gln Ile Val Cys 
                725                 730                 735     


Ser Pro Val Pro Met Leu Arg Asp Leu Thr Gln Asn Thr Val Val Ser 
            740                 745                 750         


Ile Asn Phe Lys Asp Pro Gln Phe Ala Glu Asp Tyr Ile Phe Lys Ala 
        755                 760                 765             


Val Met Leu Pro Gly Ala Arg Lys Pro Ala Ala Val Leu Lys Pro Ser 
    770                 775                 780                 


Asp Trp Glu Lys Ser Ser Asn Gly Arg Gln Trp Lys Pro Gln Leu Gly 
785                 790                 795                 800 


Phe Asn Arg Asp Arg Arg Pro Val His Leu Asp Gln Ala Ala Phe Arg 
                805                 810                 815     


Thr Leu Gly His Val Met Pro Arg Gly Ser Gly Thr Gly Ile Tyr Ser 
            820                 825                 830         


Asn Ala Ala Pro Pro Pro Val Thr Tyr Gln Gly Asn Leu Tyr Arg Pro 
        835                 840                 845             


Leu Leu Arg Gly Gln Ala Gln Ile Pro Lys Leu Met Ser Asn Met Arg 
    850                 855                 860                 


Pro Gln Asp Ser Trp Arg Gly Pro Pro Pro Leu Phe Gln Gln Gln Arg 
865                 870                 875                 880 


Phe Asp Arg Gly Val Gly Ala Glu Pro Leu Leu Pro Trp Asn Arg Met 
                885                 890                 895     


Leu Gln Thr Gln Asn Ala Ala Phe Gln Pro Asn Gln Tyr Gln Met Leu 
            900                 905                 910         


Ala Gly Pro Gly Gly Tyr Pro Pro Arg Arg Asp Asp Arg Gly Gly Arg 
        915                 920                 925             


Gln Gly Tyr Pro Arg Glu Gly Arg Lys Tyr Pro Leu Pro Pro Pro Ser 
    930                 935                 940                 


Gly Arg Tyr Asn Trp Asn 
945                 950 


<210>  44
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Thr Glu Ser Gln Gly Thr Val Thr Phe Lys Asp Val Ala Ile Asp 
1               5                   10                  15      


Phe Thr Gln Glu Glu Trp Lys Arg Leu Asp Pro Ala Gln Arg Lys Leu 
            20                  25                  30          


Tyr Arg Asn Val Met Leu Glu Asn Tyr Asn Asn Leu Ile Thr Val Gly 
        35                  40                  45              


Tyr Pro Phe Thr Lys Pro Asp Val Ile Phe Lys Leu Glu Gln Glu Glu 
    50                  55                  60                  


Glu Pro Trp Val Met Glu Glu Glu Val Leu Arg Arg His Trp Gln Gly 
65                  70                  75                  80  


Glu Ile Trp Gly Val Asp Glu His Gln Lys Asn Gln Asp Arg Leu Leu 
                85                  90                  95      


Arg Gln Val Glu Val Lys Phe Gln Lys Thr Leu Thr Glu Glu Lys Gly 
            100                 105                 110         


Asn Glu Cys Gln Lys Lys Phe Ala Asn Val Phe Pro Leu Asn Ser Asp 
        115                 120                 125             


Phe Phe Pro Ser Arg His Asn Leu Tyr Glu Tyr Asp Leu Phe Gly Lys 
    130                 135                 140                 


Cys Leu Glu His Asn Phe Asp Cys His Asn Asn Val Lys Cys Leu Met 
145                 150                 155                 160 


Arg Lys Glu His Cys Glu Tyr Asn Glu Pro Val Lys Ser Tyr Gly Asn 
                165                 170                 175     


Ser Ser Ser His Phe Val Ile Thr Pro Phe Lys Cys Asn His Cys Gly 
            180                 185                 190         


Lys Gly Phe Asn Gln Thr Leu Asp Leu Ile Arg His Leu Arg Ile His 
        195                 200                 205             


Thr Gly Glu Lys Pro Tyr Glu Cys Ser Asn Cys Arg Lys Ala Phe Ser 
    210                 215                 220                 


His Lys Glu Lys Leu Ile Lys His Tyr Lys Ile His Ser Arg Glu Gln 
225                 230                 235                 240 


Ser Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ile Lys Met Ser Asn 
                245                 250                 255     


Leu Ile Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Ala Cys 
            260                 265                 270         


Lys Glu Cys Glu Lys Ser Phe Ser Gln Lys Ser Asn Leu Ile Asp His 
        275                 280                 285             


Glu Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly 
    290                 295                 300                 


Lys Ala Phe Ser Gln Lys Gln Ser Leu Ile Ala His Gln Lys Val His 
305                 310                 315                 320 


Thr Gly Glu Lys Pro Tyr Ala Cys Asn Glu Cys Gly Lys Ala Phe Pro 
                325                 330                 335     


Arg Ile Ala Ser Leu Ala Leu His Met Arg Ser His Thr Gly Glu Lys 
            340                 345                 350         


Pro Tyr Lys Cys Asp Lys Cys Gly Lys Ala Phe Ser Gln Phe Ser Met 
        355                 360                 365             


Leu Ile Ile His Val Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
    370                 375                 380                 


Asn Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Ala Leu Thr Val His 
385                 390                 395                 400 


Met Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Arg 
                405                 410                 415     


Lys Ala Phe Ser His Lys Lys Asn Phe Ile Thr His Gln Lys Ile His 
            420                 425                 430         


Thr Arg Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ile 
        435                 440                 445             


Gln Met Ser Asn Leu Val Arg His Gln Arg Ile His Thr Gly Glu Lys 
    450                 455                 460                 


Pro Tyr Ile Cys Lys Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Asn 
465                 470                 475                 480 


Leu Ile Ala His Glu Lys Ile His Ser Gly Glu Lys Pro Tyr Glu Cys 
                485                 490                 495     


Asn Glu Cys Gly Lys Ala Phe Ser Gln Lys Gln Asn Phe Ile Thr His 
            500                 505                 510         


Gln Lys Val His Thr Gly Glu Lys Pro Tyr Asp Cys Asn Glu Cys Gly 
        515                 520                 525             


Lys Ala Phe Ser Gln Ile Ala Ser Leu Thr Leu His Leu Arg Ser His 
    530                 535                 540                 


Thr Gly Glu Lys Pro Tyr Glu Cys Asp Lys Cys Gly Lys Ala Phe Ser 
545                 550                 555                 560 


Gln Cys Ser Leu Leu Asn Leu His Met Arg Ser His Thr Gly Glu Lys 
                565                 570                 575     


Pro Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Arg Thr Ser 
            580                 585                 590         


Leu Ile Val His Met Arg Gly His Thr Gly Glu Lys Pro Tyr Glu Cys 
        595                 600                 605             


Asn Lys Cys Gly Lys Ala Phe Ser Gln Ser Ser Ser Leu Thr Ile His 
    610                 615                 620                 


Ile Arg Gly His Thr Gly Glu Lys Pro Phe Asp Cys Ser Lys Cys Gly 
625                 630                 635                 640 


Lys Ala Phe Ser Gln Ile Ser Ser Leu Thr Leu His Met Arg Lys His 
                645                 650                 655     


Thr Gly Glu Lys Pro Tyr His Cys Ile Glu Cys Gly Lys Ala Phe Ser 
            660                 665                 670         


Gln Lys Ser His Leu Val Arg His Gln Arg Ile His Thr His 
        675                 680                 685     


<210>  45
<211>  1721
<212>  PRT
<213>  Homo sapiens

<400>  45

Val Pro Pro Gly Gly Ser Ser Val Cys Thr Ala Val Gly Ser Cys Glu 
1               5                   10                  15      


Leu Val Gln Arg Gly Pro Ser Gly Pro Ala Pro Gly His Met Arg Arg 
            20                  25                  30          


Pro Pro Pro Leu Gly Pro Thr Thr Ala Ser Gly Pro Glu Gly Asn Val 
        35                  40                  45              


Arg Asn Leu Gln Lys Arg Gln Ala Pro Gly Pro Gly Ala Ala Gly Gly 
    50                  55                  60                  


Cys Gly Pro Glu Ala Gly Gly Cys Arg Glu Asn Lys Gln Lys Arg Arg 
65                  70                  75                  80  


Met Val Ala Arg Ala Thr Pro Gly Arg Gly Glu Val Glu Ser Asp Lys 
                85                  90                  95      


Ser Val Ala Ala Ser Gly Ala Gly Lys Ala Ala Arg Arg Gln Val Glu 
            100                 105                 110         


Gly Arg Arg Gly Pro Val Ser Pro Ser Asp Ser Ser Asp Pro Arg Gly 
        115                 120                 125             


Leu Glu Ala Ala Lys Glu Ala Glu Leu Pro Leu Gln Thr Glu Arg His 
    130                 135                 140                 


Thr Lys Glu Lys Arg Lys Val Thr Glu Ala Ser Ser Asp Asp Pro Gln 
145                 150                 155                 160 


Pro Gly Leu Asp Leu Val Arg Lys Glu Ser Leu Thr Ser Ser Glu Ser 
                165                 170                 175     


Phe Gln Thr Val Glu Cys Leu Gln Ser Leu Gly Lys Glu Ser Ile Ile 
            180                 185                 190         


Glu Gly Ile Lys Arg Arg Ile Arg Asn Lys Lys Leu Lys Ser Leu Glu 
        195                 200                 205             


Asn Pro Pro Leu Lys Ile Thr Glu Asn Glu Ala Thr Gln Asn Ile Lys 
    210                 215                 220                 


Val Glu Phe Gln Asp Glu Leu Tyr Lys Asn Thr Pro Lys Tyr Ser Cys 
225                 230                 235                 240 


Asn Ile Leu Ser Pro Glu Val Glu Asn Asn Ser Val Leu Lys Leu Arg 
                245                 250                 255     


Asp Cys Asn Cys Phe Pro His Ser Lys Gly Cys Asn Asp Glu Asn Asn 
            260                 265                 270         


Leu Pro Tyr Lys Pro Asp Gly Gly Cys Met His Val Ala Glu Asn Phe 
        275                 280                 285             


Ser Lys Lys Glu Asn Leu Arg Ser Leu Ala Glu Lys Ser Asp Thr Asn 
    290                 295                 300                 


Ser Ile Pro Gln Leu Leu Gln Thr Glu Glu Asn Val Met Gly Val Asn 
305                 310                 315                 320 


Lys Leu Leu Pro Glu Glu Ser Asp Leu Tyr Gln Ser Lys Thr Asn Gly 
                325                 330                 335     


Leu Leu Ser Cys Leu Gln His Glu Lys Asn Lys Tyr Ser Ile Glu Glu 
            340                 345                 350         


Ser Ser Val Gly Arg Lys Pro Arg Lys Arg Met Lys Leu Ser Glu Lys 
        355                 360                 365             


Ala Asp Glu Thr Val Thr Glu Met Asn Phe Ser Asn Glu Tyr Asn Lys 
    370                 375                 380                 


Ser Glu Leu Met Leu Gln Glu Asn Gln Met Ile Ala Asp Gly Lys Glu 
385                 390                 395                 400 


Ala Glu Thr Lys Ser Pro Leu Asn Val Leu Arg Lys Val Ser His Asn 
                405                 410                 415     


Thr Val Ser Leu Met Asp His Leu Leu Ser Val Pro Glu Thr Val Glu 
            420                 425                 430         


Lys Glu Thr Ser Ser Glu His His Val Asn Ala Val Phe Gln Lys Thr 
        435                 440                 445             


Ile Glu Pro Leu Leu Lys Glu Glu Thr Glu Asn Ala Ser Glu Pro Leu 
    450                 455                 460                 


Gly Tyr Glu Ser Met Ala Ser Lys Glu Asp Phe Lys Ser Met Lys Ser 
465                 470                 475                 480 


Phe Ile Gly Lys Ser Pro Asn Glu Tyr His Ile Glu Arg Arg Ser Ser 
                485                 490                 495     


Arg Glu Asp Leu Arg Ser Ala Ser Glu Glu Leu Lys Leu Ser Cys Gln 
            500                 505                 510         


Arg Thr Ile Pro Met Thr Gly Lys Arg Thr Trp Pro Tyr Tyr Ser Cys 
        515                 520                 525             


Ala Arg Ile Ser Ala Trp Cys Trp Lys Lys Ala Ser Leu Pro Glu Ser 
    530                 535                 540                 


Ser Tyr Phe Leu Arg Gly Ser Gln Glu Ser Cys Arg Gln Val Asp Val 
545                 550                 555                 560 


Pro Lys His Gln Thr Asn Gln Thr His Leu Thr Asp Ser Lys Leu Leu 
                565                 570                 575     


Leu Gln Ser Ser Leu Thr Glu Thr Asn Thr Glu Ser Ser Ser Lys Glu 
            580                 585                 590         


Lys Leu Asp Ser Asn Ser Asn Cys Leu Ser Ser Val Ser Ala Val Glu 
        595                 600                 605             


Pro Thr Leu Met Val Ile Lys Glu Pro Ile Ile Lys Asp Asp Lys Lys 
    610                 615                 620                 


Ile Lys Ser Glu Glu Leu Ser Arg Arg Gly Ser Glu Val Ile Ser Asn 
625                 630                 635                 640 


Thr Thr Glu Asp Thr Gln Leu Thr Ser Glu Thr Gln Ser Leu Thr Gly 
                645                 650                 655     


Asn Lys Lys Lys Ala Arg Gly Asn Leu Thr Lys Leu Asn Leu Thr Ala 
            660                 665                 670         


Thr Ser Lys Asp Gly Gln Glu Ala Asn Asn Ser Ala Gly Lys Thr Ile 
        675                 680                 685             


His Arg Lys Ala Cys Ile Ala Gln Gln Thr Phe Ile Val Pro Asp Leu 
    690                 695                 700                 


Val Lys Ile Leu Asn Thr Gly Arg Leu Thr Asn Phe Lys Ile Pro Leu 
705                 710                 715                 720 


Leu Lys Asn Lys Ser Glu Lys Arg Lys Glu Val Asn Ala Lys Ser Ser 
                725                 730                 735     


Glu Arg Glu Ala Tyr Ser Pro Leu Glu Leu Leu Asp Asn Leu Ser Gly 
            740                 745                 750         


Ala Asp Val Arg Gln Asn Arg Ser Lys Glu Asn Val Ser Met Met Met 
        755                 760                 765             


Leu Gly Pro Gln Thr Leu Ser Ile Arg Asn Ser Val Thr Pro Val Gln 
    770                 775                 780                 


Ala Ser Ser Asp Ser Phe Tyr Asn Lys Lys Ser Tyr Ser Ile Ser Pro 
785                 790                 795                 800 


Ser Phe Thr Lys Gln Gly Asn Asn Ser Lys Pro Ser Asn His Val Ser 
                805                 810                 815     


Glu Pro Gly Asn Ile Val Ser Asn Lys Glu Val Ala Ser Leu Thr Val 
            820                 825                 830         


Glu Asn Asn Ala Phe Ser Cys Asp Pro Gly Tyr Val Glu Lys Ser Pro 
        835                 840                 845             


Ser Phe Cys Cys Asn Glu Gln Glu Thr Phe Arg Pro Val Ser Ser Glu 
    850                 855                 860                 


Val Arg Gly Arg Lys Ile Thr Lys Asn Phe Ser Glu Val Gly Phe Pro 
865                 870                 875                 880 


Asp Ile Leu Lys Ala Tyr Glu Asp Asp Val Leu Leu Ile Asp Val Ile 
                885                 890                 895     


Gln Asp Asp Pro Asp Leu Phe Gly Val Ser Asn Glu Gly Glu Leu Ser 
            900                 905                 910         


Phe Thr Ser Glu Val Pro Lys Ile Ser Gln Glu Pro Asn Val Ala Gly 
        915                 920                 925             


Glu His Gln Ser Thr Asp Ser Lys Tyr Met Glu Thr Pro Val Lys Lys 
    930                 935                 940                 


Glu Pro Ser Asp Asp Leu Arg Glu Leu Pro Val Leu Asp Cys Gly Trp 
945                 950                 955                 960 


Ile Lys Pro Asp Ile Cys Ala Ser Asn Ser Ala Glu Ser Glu Ile Lys 
                965                 970                 975     


Arg Asp Pro Lys Asp Val Asn Thr Ser Leu Gly Glu Val Ala Asn Glu 
            980                 985                 990         


Thr Ser Glu Asn Glu Thr Leu Gly  Asp Phe Ser Glu Gln  Ile Lys Gly 
        995                 1000                 1005             


Ser Asp  Leu Asp Glu Lys His  Arg Phe Thr Asp Lys  Val Ile Thr 
    1010                 1015                 1020             


Lys Glu  Glu Lys Glu Asn Ile  Tyr Glu Val Cys Lys  Ser Lys Asp 
    1025                 1030                 1035             


Ser Arg  Asn Ala Asp Phe Met  Val Gly Glu Cys Gln  Phe Ala Val 
    1040                 1045                 1050             


Pro Val  Pro Lys Pro Leu Cys  Leu Leu Val Pro Pro  Leu Asn Leu 
    1055                 1060                 1065             


Ser Gly  Arg Gln Glu Asp Thr  Ile Leu Asn Thr Trp  Met Asn Asp 
    1070                 1075                 1080             


Phe Arg  Phe Leu Gly Lys His  Ser Val Leu Lys Leu  Gln Asn Pro 
    1085                 1090                 1095             


Glu Thr  Cys Glu Ile Phe Lys  Arg Glu Lys Asn Val  Gly Val Phe 
    1100                 1105                 1110             


Gln Lys  Ser Leu Gly Leu Met  Ile Pro Tyr Lys Tyr  Cys Lys Phe 
    1115                 1120                 1125             


His Phe  Asn Thr Leu Arg Gly  Cys Glu Arg Pro Leu  Cys Lys Phe 
    1130                 1135                 1140             


Ala His  Val Pro Glu Gln Gly  Asp Glu Lys Val Cys  Met Asp Val 
    1145                 1150                 1155             


Phe Lys  Lys Tyr Ile Asn Ile  Asn Glu Leu Cys Leu  Leu Gln Arg 
    1160                 1165                 1170             


Ala Val  Asn Ile Phe Met Glu  Tyr Tyr Arg Lys Phe  Pro Pro Gly 
    1175                 1180                 1185             


Val Tyr  Phe Asp Leu Gln Val  Leu Asn Asp Leu Leu  Asn Ser Leu 
    1190                 1195                 1200             


Leu Lys  His Cys Leu Leu Lys  Glu Val Phe Gln Ile  Val Asn Leu 
    1205                 1210                 1215             


Ser Ile  Met Val Lys Met Leu  Pro Ser Leu Lys Ile  Leu Leu Asn 
    1220                 1225                 1230             


Ile Phe  Glu Tyr Val Ala Thr  Met Lys Leu Arg Asn  Ala Val Pro 
    1235                 1240                 1245             


Ala Leu  Ile Asp Ile Phe Cys  Lys Leu Val Glu Ala  Gly Met Val 
    1250                 1255                 1260             


Leu Asp  Pro Glu His Phe Asn  Tyr Ile Val Lys Leu  Leu Tyr Gln 
    1265                 1270                 1275             


Val Gln  Ala Ser Lys Gln Glu  Ile Thr Ala Val Leu  Glu Met Lys 
    1280                 1285                 1290             


Ser Arg  Leu Gln Met Arg Arg  Phe Lys Lys Asn Trp  Lys Cys Asp 
    1295                 1300                 1305             


Leu Asp  Ser Ala Leu Asn Lys  Leu Glu His Cys Lys  Glu Lys Gly 
    1310                 1315                 1320             


Asp Trp  Thr Lys Leu Gly Lys  Leu Tyr Ile Asn Val  Lys Met Gly 
    1325                 1330                 1335             


Cys Glu  Lys Phe Ala Asp Phe  Gln Thr Phe Cys Ala  Cys Ile Ala 
    1340                 1345                 1350             


Glu Thr  Leu Thr Lys Asn Tyr  Glu Asp Glu Arg Pro  Asp Ile Pro 
    1355                 1360                 1365             


Phe Cys  Glu Phe Ala Glu Thr  Val Ser Lys Asp Pro  Gln Asn Ser 
    1370                 1375                 1380             


Lys Val  Asp Lys Gly Val Leu  Gly Arg Ile Gly Ile  Ser Ala Met 
    1385                 1390                 1395             


Tyr Phe  Tyr His Lys Leu Leu  Gln Trp Ser Lys Gly  Arg Lys Val 
    1400                 1405                 1410             


Leu Glu  Lys Leu Tyr Glu Leu  Lys Ile His Phe Thr  Ser Leu Lys 
    1415                 1420                 1425             


Gly Leu  Ile Gly Pro Glu Lys  Leu Ala Ser Arg Cys  Gln Ile Val 
    1430                 1435                 1440             


Asn Val  Ala Ala Glu Ile Phe  Leu Lys Ser Gly Ser  Leu Asp Gly 
    1445                 1450                 1455             


Ala Ile  Trp Val Met Arg Glu  Ser Glu Trp Ile Ile  Asn Thr Pro 
    1460                 1465                 1470             


Leu Trp  Pro Cys Asp Arg Leu  Asp Val Leu Asn Arg  His Asn Leu 
    1475                 1480                 1485             


Leu Cys  Thr Ile Ala His Glu  Ile Leu Ala Lys Ser  Leu Tyr Arg 
    1490                 1495                 1500             


Gln Thr  Phe Glu Val Leu Gln  Asn Leu Pro Gly Phe  Gln Asn Ser 
    1505                 1510                 1515             


Gln Glu  Thr Val Glu Val Ser  Gln Tyr Ser Leu Leu  Phe Asn Lys 
    1520                 1525                 1530             


Leu Leu  Gly Ser Cys Ile Glu  Ser Ser Ser Leu Gly  Met Ser Ser 
    1535                 1540                 1545             


Ser Val  Ala Glu Phe Met Ile  Ser Lys Ser Ile Pro  Ile Asp Phe 
    1550                 1555                 1560             


Ser Phe  Leu Arg Arg Leu Ile  Thr Ser Leu Gly Arg  Ser Arg Leu 
    1565                 1570                 1575             


Trp Leu  Lys Ala Arg Ala His  Tyr Lys Ser Ala Leu  Ser Leu Gly 
    1580                 1585                 1590             


Cys Tyr  Pro Pro Leu Glu Gly  Asn Leu Tyr Arg Lys  Leu Leu Leu 
    1595                 1600                 1605             


Ile Pro  Ser Tyr Leu Ser Glu  Ile Glu Met Leu Leu  Ala Ile Glu 
    1610                 1615                 1620             


Ile Phe  Met Val Ser Asn Ala  Ser Ser Ile Gln Ser  Pro Gly Thr 
    1625                 1630                 1635             


Ser Thr  Gln Ile Leu Gln Ile  Val Leu Lys Arg Cys  Glu Asp Asn 
    1640                 1645                 1650             


Gln Ser  Arg Ser Asn Asp Asp  Tyr Gln Ala Ala Val  Glu Arg Leu 
    1655                 1660                 1665             


Ile Met  Ala Ala Arg Ile Ser  Asp Pro Lys Leu Phe  Val Lys His 
    1670                 1675                 1680             


Met Thr  Val Asn Val Asn Lys  Glu Gln Val Tyr Ser  Leu Glu His 
    1685                 1690                 1695             


Cys Ser  Ala Leu Lys Trp Leu  Lys Glu Asn Met Lys  Trp Ala Gly 
    1700                 1705                 1710             


Lys Val  Trp Leu Phe Ser Asn  His 
    1715                 1720     


<210>  46
<211>  700
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
    690                 695                 700 



