                         SEQUENCE LISTING

<110>  Abbott Laboratories
       Adamczyk, Maciej
       Brashear, R. Jeffrey
       Mattingly, Phillip G.
 
<120>  ISOLATED HUMAN AUTOANTIBODIES TO NATRIURETIC PEPTIDES AND METHODS
       AND KITS FOR DETECTING HUMAN AUTOANTIBODIES TO NATRIURETIC 
       PEPTIDES

<130>  9323WO01

<160>  57    

<170>  PatentIn version 3.4

<210>  1
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              


His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  


Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg 
65                  70                  75                  80  


Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr 
                85                  90                  95      


Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
            100                 105                 110         


Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys 
        115                 120                 125             


Lys Val Leu Arg Arg His 
    130                 


<210>  2
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2

His Pro Leu Gly Ser Pro Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly 
1               5                   10                  15      


Leu Gln Glu Gln Arg Asn His Leu Gln Gly Lys Leu Ser Glu Leu Gln 
            20                  25                  30          


Val Glu Gln Thr Ser Leu Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr 
        35                  40                  45              


Gly Val Trp Lys Ser Arg Glu Val Ala Thr Glu Gly Ile Arg Gly His 
    50                  55                  60                  


Arg Lys Met Val Leu Tyr Thr Leu Arg Ala Pro Arg Ser Pro Lys Met 
65                  70                  75                  80  


Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp Arg Ile Ser Ser 
                85                  90                  95      


Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            100                 105             


<210>  3
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              


His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  


Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val 
65                  70                  75      


<210>  4
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp 
1               5                   10                  15      


Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          


<210>  5
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr Arg Arg 
145                 150             


<210>  6
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg 
        115                 120                 125     


<210>  7
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly 
        


<210>  8
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Arg Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210>  9
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  9

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Ala Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  10
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Pro Gly Ala Pro Pro Lys Val Pro Arg Thr Pro Pro Ala Glu Glu 
1               5                   10                  15      


Leu Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln Lys Lys Gly Asp Lys 
            20                  25                  30          


Ala Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu 
        35                  40                  45              


Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg 
    50                  55                  60                  


Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
65                  70                  75                  80  


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
                85                  90                  95      


Ser Met Ser Gly Leu Gly Cys 
            100             


<210>  11
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu 
1               5                   10                  15      


Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
            20                  25                  30          


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
        35                  40                  45              


Ser Gly Leu Gly Cys 
    50              


<210>  12
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  12

Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
1               5                   10                  15      


Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  


<210>  13
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  14
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Val Lys Tyr Asp Pro Cys Phe Gly His Lys Ile Asp Arg Ile Asn 
1               5                   10                  15      


His Val Ser Asn Leu Gly Cys Pro Ser Leu Arg Asp Pro Arg Pro Asn 
            20                  25                  30          


Ala Pro Ser Thr Ser Ala 
        35              


<210>  15
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Pro Gly Ala Pro Pro Lys Val Pro Arg Thr Pro Pro Ala Glu Glu 
1               5                   10                  15      


Leu Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln Lys Lys Gly Asp Lys 
            20                  25                  30          


Ala Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu 
        35                  40                  45              


Leu Arg 
    50  
                       

<210>  16
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  16

Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  17

Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe Leu His Leu 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  18

Ser Arg Ala Leu Leu Leu Leu Leu Phe Leu His Leu Ala Phe Leu 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  19

Leu Leu Leu Leu Leu Phe Leu His Leu Ala Phe Leu Gly Gly Arg 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  20

Leu Leu Phe Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  21

Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  22

Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro Gly Ser 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  23

Gly Gly Arg Ser His Pro Leu Gly Ser Pro Gly Ser Ala Ser Asp 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  24

Ser His Pro Leu Gly Ser Pro Gly Ser Ala Ser Asp Leu Glu Thr 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  25

Leu Gly Ser Pro Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  26

Pro Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  27

Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn His 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  28

Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn His Leu Gln Gly 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  29

Ser Gly Leu Gln Glu Gln Arg Asn His Leu Gln Gly Lys Leu Ser 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  30

Gln Glu Gln Arg Asn His Leu Gln Gly Lys Leu Ser Glu Leu Gln 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  31

Arg Asn His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  32

Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  33

Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu Glu Pro Leu 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  34

Glu Leu Gln Val Glu Gln Thr Ser Leu Glu Pro Leu Gln Glu Ser 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  35

Val Glu Gln Thr Ser Leu Glu Pro Leu Gln Glu Ser Pro Arg Pro 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  36

Thr Ser Leu Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  37

Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  38

Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg Glu Val 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  39

Pro Arg Pro Thr Gly Val Trp Lys Ser Arg Glu Val Ala Thr Glu 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  40

Thr Gly Val Trp Lys Ser Arg Glu Val Ala Thr Glu Gly Ile Arg 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  41

Trp Lys Ser Arg Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  42

Arg Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  43

Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr Thr 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  44

Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr Thr Leu Arg Ala 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  45

Gly His Arg Lys Met Val Leu Tyr Thr Leu Arg Ala Pro Arg Ser 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  46

Lys Met Val Leu Tyr Thr Leu Arg Ala Pro Arg Ser Pro Lys Met 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  47

Leu Tyr Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  48

Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  49

Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  50

Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  51

Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp Arg Ile Ser 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  52

Ser Gly Cys Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  53

Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  54

Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  55

Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg 
1               5                   10                  15  


<210>  56
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  56

Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
1               5                   10              


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Gln Gly Ser Gly Cys Phe Gly 
1               5               

