
                                SEQUENCE LISTING

<110> Infectious Disease Research Institute
      Goto, Yasuyuki
      Reed, Steven G.

<120> RECOMBINANT POLYPROTEIN VACCINES FOR THE TREATMENT 
  AND DIAGNOSIS OF LEISHMANIASIS
  

<130> 480239.407PC

<140> PCT                  
<141> 2009-05-15  

<160> 38

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 92
<212> PRT
<213> Leishmania infantum

<400> 1
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys
                85                  90          


<210> 2
<211> 92
<212> PRT
<213> Leishmania donovani

<400> 2
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Gln Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Arg Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys
                85                  90          


<210> 3
<211> 92
<212> PRT
<213> Leishmania major

<400> 3
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys
                85                  90          


<210> 4
<211> 353
<212> PRT
<213> Leishmania infantum

<400> 4
Met Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg
 1               5                  10                  15      
Arg Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg
            20                  25                  30          
Phe Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala
        35                  40                  45              
Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr
    50                  55                  60                  
Glu Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly
65                  70                  75                  80  
Glu Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala
                85                  90                  95      
Arg Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly
            100                 105                 110         
Val Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val
        115                 120                 125             
Ile Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His
    130                 135                 140                 
Asp Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp
145                 150                 155                 160 
Phe Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala
                165                 170                 175     
Ile Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu
            180                 185                 190         
Val Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp
        195                 200                 205             
Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile
    210                 215                 220                 
Lys His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys
225                 230                 235                 240 
Lys Gln Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu
                245                 250                 255     
Ala Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile
            260                 265                 270         
Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu
        275                 280                 285             
Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val
    290                 295                 300                 
Leu Glu Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu
305                 310                 315                 320 
Ile Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly
                325                 330                 335     
Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln
            340                 345                 350         
Ala
    


<210> 5
<211> 353
<212> PRT
<213> Leishmania donovani

<400> 5
Met Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg
 1               5                  10                  15      
Arg Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg
            20                  25                  30          
Phe Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala
        35                  40                  45              
Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr
    50                  55                  60                  
Glu Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly
65                  70                  75                  80  
Glu Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala
                85                  90                  95      
Arg Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly
            100                 105                 110         
Val Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val
        115                 120                 125             
Ile Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His
    130                 135                 140                 
Asp Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp
145                 150                 155                 160 
Phe Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala
                165                 170                 175     
Ile Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu
            180                 185                 190         
Val Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp
        195                 200                 205             
Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile
    210                 215                 220                 
Lys His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys
225                 230                 235                 240 
Lys Gln Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu
                245                 250                 255     
Ala Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile
            260                 265                 270         
Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu
        275                 280                 285             
Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val
    290                 295                 300                 
Leu Glu Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu
305                 310                 315                 320 
Val Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly
                325                 330                 335     
Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln
            340                 345                 350         
Ala
    


<210> 6
<211> 353
<212> PRT
<213> Leishmania major

<400> 6
Met Ser Ala Gly Gly Arg Glu Thr Ala Pro Met Asn Leu Leu Arg Arg
 1               5                  10                  15      
Arg Asn Lys Asp Glu Ile Asn Gly Asp Val Asn Ala Ala Ala Asp Arg
            20                  25                  30          
Phe Arg Asn Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala
        35                  40                  45              
Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr
    50                  55                  60                  
Glu Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly
65                  70                  75                  80  
Glu Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala
                85                  90                  95      
Arg Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly
            100                 105                 110         
Val Gly Gly Pro Ala Arg Asn Ile Val Arg Leu Thr Arg Cys Asn Val
        115                 120                 125             
Thr Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His
    130                 135                 140                 
Asp Ala Leu Ala Gly Met Ser Cys Lys Ile Asp Tyr Val Lys Thr Asp
145                 150                 155                 160 
Phe Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala
                165                 170                 175     
Ile Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu
            180                 185                 190         
Val Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp
        195                 200                 205             
Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile
    210                 215                 220                 
Lys His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys
225                 230                 235                 240 
Lys Gln Val Ile Glu Tyr Met Lys Glu Ala Gly Phe Val Val Glu Glu
                245                 250                 255     
Ala Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile
            260                 265                 270         
Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu
        275                 280                 285             
Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Ile Met Cys Arg Val
    290                 295                 300                 
Leu Glu Phe Val His Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu
305                 310                 315                 320 
Val Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly
                325                 330                 335     
Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln
            340                 345                 350         
Ala
    


<210> 7
<211> 236
<212> PRT
<213> Leishmania infantum

<400> 7
Met Lys Ile Arg Ser Val Arg Pro Leu Val Val Leu Leu Val Cys Val
 1               5                  10                  15      
Ala Ala Val Leu Ala Leu Ser Ala Ser Ala Glu Pro His Lys Ala Ala
            20                  25                  30          
Val Asp Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu
        35                  40                  45              
Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser
    50                  55                  60                  
Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val
65                  70                  75                  80  
Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Leu Ser Val Gly
                85                  90                  95      
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro
            100                 105                 110         
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
        115                 120                 125             
Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
    130                 135                 140                 
Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
145                 150                 155                 160 
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
                165                 170                 175     
Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
            180                 185                 190         
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
        195                 200                 205             
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
    210                 215                 220                 
Val Gly Pro Gln Ser Val Asp Val Ser Pro Val Ser
225                 230                 235     


<210> 8
<211> 443
<212> PRT
<213> Leishmania infantum

<400> 8
Met Ala Thr Ser Arg Ala Ala Leu Cys Ala Val Ala Val Val Cys Val
 1               5                  10                  15      
Val Leu Ala Ala Ala Cys Ala Pro Ala Arg Ala Ile Tyr Val Gly Thr
            20                  25                  30          
Pro Ala Ala Ala Leu Phe Glu Glu Phe Lys Arg Thr Tyr Arg Arg Ala
        35                  40                  45              
Tyr Gly Thr Leu Ala Glu Glu Gln Gln Arg Leu Ala Asn Phe Glu Arg
    50                  55                  60                  
Asn Leu Glu Leu Met Arg Glu His Gln Ala Arg Asn Pro His Ala Arg
65                  70                  75                  80  
Phe Gly Ile Thr Lys Phe Phe Asp Leu Ser Glu Ala Glu Phe Ala Ala
                85                  90                  95      
Arg Tyr Leu Asn Gly Ala Ala Tyr Phe Ala Ala Ala Lys Gln His Ala
            100                 105                 110         
Gly Gln His Tyr Arg Lys Ala Arg Ala Asp Leu Ser Ala Val Pro Asp
        115                 120                 125             
Ala Val Asp Trp Arg Glu Lys Gly Ala Val Thr Pro Val Lys Asn Gln
    130                 135                 140                 
Gly Ala Cys Gly Ser Cys Trp Ala Phe Ser Ala Val Gly Asn Ile Glu
145                 150                 155                 160 
Ser Gln Trp Ala Arg Ala Gly His Gly Leu Val Ser Leu Ser Glu Gln
                165                 170                 175     
Gln Leu Val Ser Cys Asp Asp Lys Asp Asn Gly Cys Asn Gly Gly Leu
            180                 185                 190         
Met Leu Gln Ala Phe Glu Trp Leu Leu Arg His Met Tyr Gly Ile Val
        195                 200                 205             
Phe Thr Glu Lys Ser Tyr Pro Tyr Thr Ser Gly Asn Gly Asp Val Ala
    210                 215                 220                 
Glu Cys Leu Asn Ser Ser Lys Leu Val Pro Gly Ala Gln Ile Asp Gly
225                 230                 235                 240 
Tyr Val Met Ile Pro Ser Asn Glu Thr Val Met Ala Ala Trp Leu Ala
                245                 250                 255     
Glu Asn Gly Pro Ile Ala Ile Ala Val Asp Ala Ser Ser Phe Met Ser
            260                 265                 270         
Tyr Gln Ser Gly Val Leu Thr Ser Cys Ala Gly Asp Ala Leu Asn His
        275                 280                 285             
Gly Val Leu Leu Val Gly Tyr Asn Lys Thr Gly Gly Val Pro Tyr Trp
    290                 295                 300                 
Val Ile Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr Val
305                 310                 315                 320 
Arg Val Val Met Gly Leu Asn Ala Cys Leu Leu Ser Glu Tyr Pro Val
                325                 330                 335     
Ser Ala His Val Pro Arg Ser Leu Thr Pro Gly Pro Gly Thr Glu Ser
            340                 345                 350         
Glu Glu Arg Ala Pro Lys Arg Val Thr Val Glu Gln Met Met Cys Thr
        355                 360                 365             
Asp Met Tyr Cys Arg Glu Gly Cys Lys Lys Ser Leu Leu Thr Ala Asn
    370                 375                 380                 
Val Cys Tyr Lys Asn Gly Gly Gly Gly Ser Ser Met Thr Lys Cys Gly
385                 390                 395                 400 
Pro Gln Lys Val Leu Met Cys Ser Tyr Ser Asn Pro His Cys Phe Gly
                405                 410                 415     
Pro Gly Leu Cys Leu Glu Thr Pro Asp Gly Lys Cys Ala Pro Tyr Phe
            420                 425                 430         
Leu Gly Ser Ile Met Asn Thr Cys Gln Tyr Thr
        435                 440             


<210> 9
<211> 443
<212> PRT
<213> Leishmania donovani

<400> 9
Met Ala Thr Ser Arg Ala Ala Leu Cys Ala Val Ala Val Val Cys Val
 1               5                  10                  15      
Val Leu Ala Ala Ala Cys Ala Pro Ala Arg Ala Ile Tyr Val Gly Thr
            20                  25                  30          
Pro Ala Ala Ala Leu Phe Glu Glu Phe Lys Arg Thr Tyr Arg Arg Ala
        35                  40                  45              
Tyr Gly Thr Leu Ala Glu Glu Gln Gln Arg Leu Ala Asn Phe Glu Arg
    50                  55                  60                  
Asn Leu Glu Leu Met Arg Glu His Gln Ala Arg Asn Pro His Ala Arg
65                  70                  75                  80  
Phe Gly Ile Thr Lys Phe Phe Asp Leu Ser Glu Ala Glu Phe Ala Ala
                85                  90                  95      
Arg Tyr Leu Asn Gly Ala Ala Tyr Phe Ala Ala Ala Lys Gln His Ala
            100                 105                 110         
Gly Gln His Tyr Arg Lys Ala Arg Ala Asp Leu Ser Ala Val Pro Asp
        115                 120                 125             
Ala Val Asp Trp Arg Glu Lys Gly Ala Val Thr Pro Val Lys Asn Gln
    130                 135                 140                 
Gly Ala Cys Gly Ser Cys Trp Ala Phe Ser Ala Val Gly Asn Ile Glu
145                 150                 155                 160 
Ser Gln Trp Ala Arg Val Gly His Gly Leu Val Ser Leu Ser Glu Gln
                165                 170                 175     
Gln Leu Val Ser Cys Asp Asp Lys Asp Asn Gly Cys Asn Gly Gly Leu
            180                 185                 190         
Met Leu Gln Ala Phe Glu Trp Leu Leu Arg His Met Tyr Gly Ile Val
        195                 200                 205             
Phe Thr Glu Lys Ser Tyr Pro Tyr Thr Ser Gly Asn Gly Asp Val Ala
    210                 215                 220                 
Glu Cys Leu Asn Ser Ser Lys Leu Val Pro Gly Ala Gln Ile Asp Gly
225                 230                 235                 240 
Tyr Val Met Ile Pro Ser Asn Glu Thr Val Met Ala Ala Trp Leu Ala
                245                 250                 255     
Glu Asn Gly Pro Ile Ala Ile Ala Val Asp Ala Ser Ser Phe Met Ser
            260                 265                 270         
Tyr Gln Ser Gly Val Leu Thr Ser Cys Ala Gly Asp Ala Leu Asn His
        275                 280                 285             
Gly Val Leu Leu Val Gly Tyr Asn Lys Thr Gly Gly Val Pro Tyr Trp
    290                 295                 300                 
Val Ile Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr Val
305                 310                 315                 320 
Arg Val Ala Met Gly Lys Asn Ala Cys Leu Leu Ser Glu Tyr Pro Val
                325                 330                 335     
Ser Ala His Val Pro Arg Ser Leu Thr Pro Gly Pro Gly Thr Glu Ser
            340                 345                 350         
Glu Glu Arg Ala Pro Lys Arg Val Thr Val Glu Gln Val Met Cys Thr
        355                 360                 365             
Asp Met Tyr Cys Arg Glu Gly Cys Lys Lys Ser Leu Leu Thr Ala Asn
    370                 375                 380                 
Val Cys Tyr Lys Asn Gly Gly Gly Gly Ser Ser Met Thr Lys Cys Gly
385                 390                 395                 400 
Pro Lys Lys Val Leu Met Cys Ser Tyr Ser Asn Pro His Cys Phe Gly
                405                 410                 415     
Pro Gly Leu Cys Leu Glu Thr Pro Asp Gly Lys Cys Ala Pro Tyr Phe
            420                 425                 430         
Leu Gly Ser Ile Met Asn Thr Cys Gln Tyr Thr
        435                 440             


<210> 10
<211> 443
<212> PRT
<213> Leishmania major

<400> 10
Met Ala Thr Ser Arg Ala Ala Leu Cys Ala Val Ala Val Val Cys Val
 1               5                  10                  15      
Val Leu Ala Ala Ala Cys Ala Pro Ala Arg Ala Ile Tyr Val Gly Thr
            20                  25                  30          
Pro Ala Ala Ala Leu Phe Glu Glu Phe Lys Arg Thr Tyr Gln Arg Ala
        35                  40                  45              
Tyr Gly Thr Leu Thr Glu Glu Gln Gln Arg Leu Ala Asn Phe Glu Arg
    50                  55                  60                  
Asn Leu Glu Leu Met Arg Glu His Gln Ala Arg Asn Pro His Ala Arg
65                  70                  75                  80  
Phe Gly Ile Thr Lys Phe Phe Asp Leu Ser Glu Ala Glu Phe Ala Ala
                85                  90                  95      
Arg Tyr Leu Asn Gly Ala Ala Tyr Phe Ala Ala Ala Lys Gln His Ala
            100                 105                 110         
Gly Gln His Tyr Arg Lys Ala Arg Ala Asp Leu Ser Ala Val Pro Asp
        115                 120                 125             
Ala Val Asp Trp Arg Glu Lys Gly Ala Val Thr Pro Val Lys Asn Gln
    130                 135                 140                 
Gly Ala Cys Gly Ser Cys Trp Ala Phe Ser Ala Val Gly Asn Ile Glu
145                 150                 155                 160 
Ser Gln Trp Ala Val Ala Gly His Lys Leu Val Arg Leu Ser Glu Gln
                165                 170                 175     
Gln Leu Val Ser Cys Asp His Val Asp Asn Gly Cys Gly Gly Gly Leu
            180                 185                 190         
Met Leu Gln Ala Phe Glu Trp Val Leu Arg Asn Met Asn Gly Thr Val
        195                 200                 205             
Phe Thr Glu Lys Ser Tyr Pro Tyr Val Ser Gly Asn Gly Asp Val Pro
    210                 215                 220                 
Glu Cys Ser Asn Ser Ser Glu Leu Ala Pro Gly Ala Arg Ile Asp Gly
225                 230                 235                 240 
Tyr Val Ser Met Glu Ser Ser Glu Arg Val Met Ala Ala Trp Leu Ala
                245                 250                 255     
Lys Asn Gly Pro Ile Ser Ile Ala Val Asp Ala Ser Ser Phe Met Ser
            260                 265                 270         
Tyr His Ser Gly Val Leu Thr Ser Cys Ile Gly Glu Gln Leu Asn His
        275                 280                 285             
Gly Val Leu Leu Val Gly Tyr Asn Met Thr Gly Glu Val Pro Tyr Trp
    290                 295                 300                 
Val Ile Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr Val
305                 310                 315                 320 
Arg Val Thr Met Gly Val Asn Ala Cys Leu Leu Thr Gly Tyr Pro Val
                325                 330                 335     
Ser Val His Val Ser Gln Ser Pro Thr Pro Gly Pro Asn Thr Thr Thr
            340                 345                 350         
Thr Thr His Ala Pro Lys Arg Val Thr Val Lys Gln Ile Thr Cys Thr
        355                 360                 365             
Asp Tyr Phe Cys Arg Lys Gly Cys Lys Thr Thr Val Ile Pro Thr Lys
    370                 375                 380                 
Glu Cys Leu Pro Asn Gly Ala Gly Gly Ser Phe Gln Met Glu Cys Gly
385                 390                 395                 400 
Asp His Gln Val Leu Lys Leu Thr Tyr Thr Ser Met Asn Cys Thr Gly
                405                 410                 415     
Glu Ala Lys Tyr Thr Val Thr Arg Glu Gly Lys Cys Gly Ile Ser Trp
            420                 425                 430         
Ser Gly Ser Ser Lys Ser Ile Cys Gln Tyr Val
        435                 440             


<210> 11
<211> 279
<212> DNA
<213> Leishmania infantum

<400> 11
atggccacca cgtacgagga gttttcggcg aagctggacc gcctggatga ggagttcaac 60
aggaagatgc aggagcagaa cgccaagttc tttgcggaca agccggatga gtcgacgctg 120
tcgcccgaga tgaaggagca ctacgagaag ttcgagcgca tgatcaagga acacacagag 180
aagttcaaca agaagatgca cgagcactcg gagcacttca agcagaagtt cgccgagctg 240
ctcgagcagc agaaggctgc gcagtacccg tccaagtaa                        279

<210> 12
<211> 279
<212> DNA
<213> Leishmania donovani

<400> 12
atggccacca cgtacgagga gttttcggcg aagctggacc gcctggatca ggagttcaac 60
aggaagatgc aggagcagaa cgccaagttc tttgcggaca agccggatga gtcgacgctg 120
tcgcccgaga tgagagagca ctacgagaag ttcgagcgca tgatcaagga acacacagag 180
aagttcaaca agaagatgca cgagcactcg gagcacttca agcagaagtt cgccgagctg 240
ctcgagcagc agaaggctgc gcagtacccg tccaagtaa                        279

<210> 13
<211> 279
<212> DNA
<213> Leishmania major

<400> 13
atggccacca cgtacgagga gttctcggcg aagctggacc gcctggatga ggagttcaac 60
aggaagatgc aggaacagaa cgccaagttc tttgcggaca agccggatga gtcgacgctg 120
tcgcccgaga tgaaggagca ctacgagaag ttcgagcgca tgatcaagga gcacacagag 180
aagttcaaca agaagatgca cgagcactcg gagcacttca agcagaagtt cgccgagctg 240
ctcgagcagc agaaggctgc gcagtacccg tccaagtga                        279

<210> 14
<211> 1062
<212> DNA
<213> Leishmania infantum

<400> 14
atgtccgccg gtggccgtga gaccgcgccg acgaacctga ttcgtcgccg caacaaggac 60
gagacaaacg gggatgtcag cgccgccgcc gaccgcttcc gcgaccgctt cgagaaggca 120
accctcgagg agcgcaaggc cgccaccacg acgatggtca acgagtacta cgacctggtg 180
acggacttct acgagtacgg ctggggccag aacttccatt tcgcgccgcg ctacgccggc 240
gagaccttct tcgagtccct cgcgcgccac gagtacttcc tggccgctcg cggcggcttc 300
atggagggcg accacatcgt cgacgtgggc tgcggcgtcg gcggtccggc gcgcaacatg 360
gttcgcctca cgcgctgcaa cgtcatcggc gtcaacaaca acgattacca gatcagccgc 420
gctcgccgtc atgacgcgct cgccggtatg agctccaaga tcgactacgt caagaccgac 480
ttctgcaaca tgagcttagc cgacaacacc ttcgacggcg cctacgccat cgaggccacc 540
tgccacgcaa aggacaaggt caagtgctat agcgaggtct tccgtgtcat caagcccggc 600
acctgctttg tcctgtacga gtggtgcatg accgacaagt acaaccccaa tgacgagtac 660
caccgcacaa tcaagcaccg catcgagctg ggcgacggcc tgccggagat ggagacgtgc 720
aaacaggtga tcgagtacat gaagcaggcc ggcttcgtgg tggaggaggc catagacgtc 780
atcagtcagt tcgagtccag ccccatcaag agtatcccgt ggtaccagcc gctggtcggc 840
gactattcgt ccctgcaggg cctgcgctct accccgattg gccgcatcct cacgaacgtc 900
atgtgtcgcg tgctggagtt cgtgcgccta gctccgaagg gcacgtacaa ggcgacggag 960
attttggagg aggctgcgga aagcctggtg gtgggcggtc agctcggcat cttcacgccg 1020
tccttctaca tccgcgctcg caagccgtcc aagcaggctt ag                    1062

<210> 15
<211> 1062
<212> DNA
<213> Leishmania donovani

<400> 15
atgtccgccg gtggccgtga gaccgcgccg acgaacctga ttcgtcgccg caacaaggac 60
gagacaaacg gggatgtcag cgccgccgcc gaccgcttcc gcgaccgctt cgagaaggca 120
accctcgagg agcgcaaggc cgccaccacg acgatggtca acgagtacta cgacctggtg 180
acggacttct acgagtacgg ctggggccag aacttccatt tcgcgccgcg ctacgccggc 240
gagaccttct tcgagtccct cgcgcgccac gagtacttcc tggccgctcg cggcggcttc 300
atggagggcg accacatcgt cgacgtgggc tgcggcgtcg gcggtccggc gcgcaacatg 360
gttcgcctca cgcgctgcaa cgtcatcggc gtcaacaaca acgattacca gatcagccgc 420
gctcgccgtc atgacgcgct cgccggtatg agctccaaga tcgactacgt caagaccgac 480
ttctgcaaca tgagcttagc cgacaacacc ttcgacggcg cctacgccat cgaggccacc 540
tgccacgcaa aggacaaggt caagtgctat agcgaggtct tccgtgtcat caagcccggc 600
acctgctttg tcctgtacga gtggtgcatg accgacaagt acaaccccaa tgacgagtac 660
caccgcacaa tcaagcaccg catcgagctg ggcgacggcc tgccggagat ggagacgtgc 720
aaacaggtga tcgagtacat gaagcaggcc ggcttcgtgg tggaggaggc catagacgtc 780
atcagtcagt tcgaatccag ccccatcaag agtatcccgt ggtaccagcc gctggtcggc 840
gactattcgt ccctgcaggg cctgcgctct accccgattg gccgcatcct cacgaacgtc 900
atgtgtcgcg tgctggagtt cgtgcgccta gctccgaagg gcacgtacaa ggcgacggag 960
gttttggagg aggctgcgga aagcctggtg gtgggcggtc agctcggcat cttcacgccg 1020
tccttctaca tccgcgctcg caagccgtcc aagcaggctt ag                    1062

<210> 16
<211> 1062
<212> DNA
<213> Leishmania major

<400> 16
atgtctgccg gtggccgtga gaccgcgccg atgaacctgc ttcgtcgccg caacaaggat 60
gagataaacg gggatgtcaa cgccgccgcc gaccgcttcc gcaaccgctt cgagaaggca 120
accctcgagg agcgcaaggc cgccaccacg acgatggtca acgagtacta cgacctggtg 180
acggacttct acgagtacgg ctggggccag aactttcatt tcgcgccgcg ctacgccggc 240
gagaccttct tcgagtccct cgcgcgccac gagtacttcc tggccgcccg cggcggcttc 300
atggagggcg accatatcgt cgacgtgggc tgcggcgtcg gcggtccggc gcgcaacata 360
gttcgcctca cgcgctgtaa cgtcaccggc gtcaacaaca acgattacca aatcagccgc 420
gctcgccgtc atgacgcact cgccggtatg agctgcaaaa tcgactacgt caagaccgac 480
ttctgcaaca tgagcttagc cgacaacacc ttcgacggcg cctacgccat cgaggccaca 540
tgccacgcaa aggacaaggt caagtgctat agcgaggtct tccgtgtcat caagcccggc 600
acctgcttcg tcctgtacga gtggtgcatg accgacaagt acaaccccaa tgacgagtac 660
catcgcacga tcaagcaccg cattgagctg ggcgacggcc tgccggagat ggagacgtgc 720
aagcaggtga tcgagtacat gaaggaggcc ggtttcgtgg tggaggaagc catagatgtc 780
atcagtcagt tcgagtccag ccccatcaag agcatcccgt ggtaccagcc gctggttggc 840
gactactcgt ccctgcaggg cctgcgctct accccgattg gccgcatcct caccaacatc 900
atgtgtcgcg tgctggagtt cgtgcaccta gctccgaagg gcacgtacaa ggcgacggag 960
gttttggagg aggctgcgga aagcctggtg gtgggcggtc agctcggcat cttcacgccg 1020
tccttctaca tccgcgctcg caagccgtcc aagcaggcct ag                    1062

<210> 17
<211> 711
<212> DNA
<213> Leishmania infantum

<400> 17
atgaagatcc gcagcgtgcg tccgcttgtg gtgttgctgg tgtgcgtcgc ggcggtgctc 60
gcactcagcg cctccgctga gccgcacaag gcggccgttg acgtcggccc gctctccgtt 120
ggcccgcagt ccgtcggccc gctctctgtt ggcccgcagg ctgttggccc gctctccgtt 180
ggcccgcagt ccgtcggccc gctctctgtt ggcccgcagg ctgttggccc gctctctgtt 240
ggcccgcagt ccgttggccc gctctccgtt ggcccgctct ccgttggccc gcagtctgtt 300
ggcccgctct ccgttggctc gcagtccgtc ggcccgctct ctgttggtcc gcagtccgtc 360
ggcccgctct ccgttggccc gcaggctgtt ggcccgctct ccgttggccc gcagtccgtc 420
ggcccgctct ctgttggccc gcaggctgtt ggcccgctct ctgttggccc gcagtccgtt 480
ggcccgctct ccgttggccc gcagtctgtt ggcccgctct ccgttggctc gcagtccgtc 540
ggcccgctct ctgttggtcc gcagtccgtc ggcccgctct ccgttggccc gcagtctgtc 600
ggcccgctct ccgttggccc gcagtccgtc ggcccgctct ccgttggtcc gcagtccgtt 660
ggcccgctct ccgttggccc gcagtccgtt gacgtttctc cggtgtctta a          711

<210> 18
<211> 1332
<212> DNA
<213> Leishmania infantum

<400> 18
atggcgacgt cgagggccgc tctctgcgct gttgcggtcg tgtgcgtggt gcttgcggct 60
gcctgcgcgc ctgcgcgcgc gatatacgtg ggcacgccgg ctgctgcgct gttcgaggag 120
ttcaagcgga cgtaccggcg cgcgtacggg acgctggccg aggagcagca gcggctggcg 180
aacttcgagc gcaacctgga gctgatgcgc gagcatcagg cgaggaaccc acacgcgagg 240
ttcgggatca cgaagttctt cgacctgtcg gaggcggagt tcgccgcgcg ctacctgaac 300
ggcgccgcgt acttcgcagc ggcgaagcag cacgccggcc agcactaccg caaggcgcgc 360
gcggacctgt cggcggtgcc tgatgcggtg gactggcgcg agaagggcgc cgtgacgccg 420
gtgaagaatc aaggcgcgtg cgggtcgtgc tgggcgttct cggcggtcgg caacatcgag 480
tcgcagtggg cccgtgccgg ccacggcttg gtgagcctgt cggagcagca gctggtgagc 540
tgcgatgaca aagacaatgg ctgcaacggc gggctgatgc tgcaggcgtt cgagtggctg 600
ctgcgacaca tgtacgggat cgtgttcacg gagaagagct acccctacac gtccggcaac 660
ggtgatgtgg ccgagtgctt gaacagcagt aaactcgttc ccggcgcgca aatcgacggc 720
tacgtgatga tcccgagcaa cgaaacggtt atggctgcgt ggcttgcgga gaatggcccc 780
atcgcgattg cggtcgacgc cagctccttc atgtcttacc agagcggcgt gctgaccagc 840
tgcgctggcg atgcactgaa ccacggcgtg ctgctcgtcg ggtacaacaa gaccggtggg 900
gttccgtact gggtgatcaa gaactcgtgg ggtgaggact ggggcgagaa gggctacgtg 960
cgcgtggtca tggggctgaa cgcgtgcctg ctcagtgaat accccgtgtc cgcgcatgtg 1020
ccgcggagtc tcacccctgg cccgggcacg gagagcgagg agcgcgcccc taaacgggtg 1080
acggtggagc agatgatgtg caccgatatg tactgcaggg aggggtgcaa gaagagtctt 1140
ctcaccgcga acgtgtgcta caagaacggg ggaggcggct cctctatgac gaagtgcggt 1200
ccgcagaagg tgctgatgtg ctcgtactcg aaccctcatt gctttggtcc tgggctgtgc 1260
ctcgagactc ctgatggcaa gtgcgcgccg tacttcttgg gctcgatcat gaacacctgc 1320
cagtacacgt ag                                                     1332

<210> 19
<211> 1332
<212> DNA
<213> Leishmania donovani

<400> 19
atggcgacgt cgagggccgc tctctgcgct gttgcggtcg tgtgcgtggt gcttgcggct 60
gcctgcgcgc ctgcgcgcgc gatatacgtg ggcacgccgg ctgctgcgct gttcgaggag 120
ttcaagcgga cgtaccggcg cgcgtacggg acgctggccg aggagcagca gcggctggcg 180
aacttcgagc gcaacctgga gctgatgcgc gagcatcagg cgaggaaccc acacgcgagg 240
ttcgggatca cgaagttctt cgacctgtcg gaggcggagt tcgccgcgcg ctacctgaac 300
ggcgccgcgt acttcgcagc ggcgaagcag cacgccggcc agcactaccg caaggcgcgc 360
gcggacctgt cggcggtgcc tgatgcggtg gactggcgcg agaagggcgc cgtgacgccg 420
gtgaagaatc aaggcgcgtg cgggtcgtgc tgggcgttct cggcggtcgg caacatcgag 480
tcgcagtggg cccgtgtcgg ccacggcttg gtgagcctgt cggagcagca gctggtgagc 540
tgcgatgaca aagacaatgg ctgcaacggc gggctgatgc tgcaggcgtt cgagtggctg 600
ctgcgacaca tgtacgggat cgtgttcacg gagaagagct acccctacac gtccggcaac 660
ggtgatgtgg ccgagtgctt gaacagcagt aaactcgttc ccggcgcgca aatcgacggc 720
tacgtgatga tcccgagcaa cgaaacagtt atggctgcgt ggcttgcgga gaatggcccc 780
atcgcgattg cggtcgacgc cagctccttc atgtcttacc agagcggcgt gctgaccagc 840
tgcgctggcg atgcactgaa ccacggcgtg ctgctcgtcg ggtacaacaa gaccggtggg 900
gttccgtact gggtgatcaa gaactcgtgg ggtgaggact ggggcgagaa gggctacgtg 960
cgcgtggcca tggggaagaa cgcgtgcctg ctcagtgaat accccgtgtc cgcgcatgtg 1020
ccgcggagtc tcacccctgg gccgggcacg gagagcgagg agcgcgctcc taaacgggtg 1080
acggtggagc aggtgatgtg caccgatatg tactgcaggg aggggtgcaa gaagagtctt 1140
ctcaccgcga acgtgtgcta caagaacggg ggaggcggct cctctatgac gaagtgcggt 1200
ccgaagaagg tgctgatgtg ctcgtactcg aaccctcatt gctttggtcc tgggctgtgc 1260
ctcgagactc ctgatggcaa gtgcgcgccg tacttcttgg gctcgatcat gaacacctgc 1320
cagtacacgt ag                                                     1332

<210> 20
<211> 1332
<212> DNA
<213> Leishmania major

<400> 20
atggcgacgt cgagggccgc tctctgcgct gttgcggttg tgtgcgtggt gcttgcggct 60
gcctgcgcgc ccgcgcgcgc gatatacgtg ggcacgccgg ctgctgcgct gttcgaggag 120
ttcaagcgga cgtaccagcg cgcgtacggg acgctgaccg aggagcagca gcggctggcg 180
aacttcgagc gcaacctgga gctgatgcgc gagcatcagg cgaggaaccc acacgcgagg 240
ttcgggatca cgaagttctt tgacctgtcg gaggcggagt tcgccgcgcg ctacctgaac 300
ggcgccgcgt acttcgcagc ggcgaagcag cacgccggcc agcactaccg caaggcgcgc 360
gcggacctgt cggcggtgcc tgatgcggtg gactggcgcg agaagggcgc cgtgacgccg 420
gtgaagaatc agggtgcgtg cgggtcgtgc tgggcgttct cggcggtcgg caacatcgag 480
tcgcagtggg ccgttgccgg ccacaagctg gtgaggctgt cggagcagca gctggtgagc 540
tgcgatcacg tggacaatgg ttgcggcggc gggctgatgc tgcaggcatt cgagtgggtg 600
ctgcgaaaca tgaacgggac cgtgttcacg gagaagagct acccctacgt ctccggcaac 660
ggtgatgtgc ccgagtgctc gaacagcagt gaactcgctc ccggtgcgcg aatcgacggg 720
tacgtgtcga tggaaagcag cgaaagagtt atggctgcgt ggcttgcgaa gaatggcccc 780
atctcgattg cggtcgacgc cagctccttt atgtcttacc atagcggcgt cctgaccagc 840
tgcattggtg agcagctgaa ccacggcgtg ctgctcgttg ggtacaacat gactggtgag 900
gttccgtact gggtgatcaa gaactcgtgg ggtgaggact ggggcgagaa gggctacgtg 960
cgcgtgacca tgggggtgaa cgcgtgcctg ctcactgggt accccgtgtc cgtgcatgtg 1020
tcgcagagcc ccacccctgg cccaaacacg accaccacga cgcacgctcc taaacgggtg 1080
acggtgaagc agatcacctg cacggattat ttctgccgaa aggggtgcaa gacgacggtg 1140
atccccacga aagagtgcct gccgaacggg gcaggcggct cttttcagat ggagtgcggt 1200
gaccatcagg tgttgaagct cacctacacc tccatgaatt gcactggtga ggccaagtat 1260
acggtgacaa gggagggtaa gtgcgggata tcgtggtccg gctcgagcaa gagcatttgc 1320
cagtacgtgt ag                                                     1332

<210> 21
<211> 660
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence for a KSA fusion polypeptide.

<400> 21
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys Thr Ser Ser Ala
                85                  90                  95      
Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys
            100                 105                 110         
Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp
        115                 120                 125             
Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr
    130                 135                 140                 
Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly
145                 150                 155                 160 
Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe
                165                 170                 175     
Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly
            180                 185                 190         
Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val Gly Gly
        195                 200                 205             
Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val
    210                 215                 220                 
Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu
225                 230                 235                 240 
Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn
                245                 250                 255     
Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala
            260                 265                 270         
Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg
        275                 280                 285             
Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr
    290                 295                 300                 
Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg
305                 310                 315                 320 
Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val
                325                 330                 335     
Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp
            340                 345                 350         
Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr
        355                 360                 365             
Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr
    370                 375                 380                 
Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe
385                 390                 395                 400 
Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu
                405                 410                 415     
Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr
            420                 425                 430         
Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Gly Ser
        435                 440                 445             
Glu Pro His Lys Ala Ala Val Asp Val Gly Pro Leu Ser Val Gly Pro
    450                 455                 460                 
Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu
465                 470                 475                 480 
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala
                485                 490                 495     
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
            500                 505                 510         
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
        515                 520                 525             
Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    530                 535                 540                 
Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln
545                 550                 555                 560 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser
                565                 570                 575     
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
            580                 585                 590         
Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly
        595                 600                 605             
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    610                 615                 620                 
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
625                 630                 635                 640 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Asp Val Ser Pro
                645                 650                 655     
Val Ser Gly Ser 
            660         


<210> 22
<211> 1989
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic acid sequence encoding the KSA fusion
      polypeptide.

<400> 22
atggccacca cgtacgagga gttttcggcg aagctggacc gcctggatga ggagttcaac 60
aggaagatgc aggagcagaa cgccaagttc tttgcggaca agccggatga gtcgacgctg 120
tcgcccgaga tgaaggagca ctacgagaag ttcgagcgca tgatcaagga acacacagag 180
aagttcaaca agaagatgca cgagcactcg gagcacttca agcagaagtt cgccgagctg 240
ctcgagcagc agaaggctgc gcagtacccg tccaagacta gttccgccgg tggccgtgag 300
accgcgccga cgaacctgat tcgtcgccgc aacaaggacg agacaaacgg ggatgtcagc 360
gccgccgccg accgcttccg cgaccgcttc gagaaggcaa ccctcgagga gcgcaaggcc 420
gccaccacga cgatggtcaa cgagtactac gacctggtga cggacttcta cgagtacggc 480
tggggccaga acttccattt cgcgccgcgc tacgccggcg agaccttctt cgagtccctc 540
gcgcgccacg agtacttcct ggccgctcgc ggcggcttca tggagggcga ccacatcgtc 600
gacgtgggct gcggcgtcgg cggtccggcg cgcaacatgg ttcgcctcac gcgctgcaac 660
gtcatcggcg tcaacaacaa cgattaccag atcagccgcg ctcgccgtca tgacgcgctc 720
gccggtatga gctccaagat cgactacgtc aagaccgact tctgcaacat gagcttagcc 780
gacaacacct tcgacggcgc ctacgccatc gaggccacct gccacgcaaa ggacaaggtc 840
aagtgctata gcgaggtctt ccgtgtcatc aagcccggca cctgctttgt cctgtacgag 900
tggtgcatga ccgacaagta caaccccaat gacgagtacc accgcacaat caagcaccgc 960
atcgagctgg gcgacggcct gccggagatg gagacgtgca aacaggtgat cgagtacatg 1020
aagcaggccg gcttcgtggt ggaggaggcc atagacgtca tcagtcagtt cgagtccagc 1080
cccatcaaga gtatcccgtg gtaccagccg ctggtcggcg actattcgtc cctgcagggc 1140
ctgcgctcta ccccgattgg ccgcatcctc acgaacgtca tgtgtcgcgt gctggagttc 1200
gtgcgcctag ctccgaaggg cacgtacaag gcgacggaga ttttggagga ggctgcggaa 1260
agcctggtgg tgggcggtca gctcggcatc ttcacgccgt ccttctacat ccgcgctcgc 1320
aagccgtcca agcaggctgg atccgagccg cacaaggcgg ccgttgacgt cggcccgctc 1380
tccgttggcc cgcagtccgt cggcccgctc tctgttggcc cgcaggctgt tggcccgctc 1440
tccgttggcc cgcagtccgt cggcccgctc tctgttggcc cgcaggctgt tggcccgctc 1500
tctgttggcc cgcagtccgt tggcccgctc tccgttggcc cgctctccgt tggcccgcag 1560
tctgttggcc cgctctccgt tggctcgcag tccgtcggcc cgctctctgt tggtccgcag 1620
tccgtcggcc cgctctccgt tggcccgcag gctgttggcc cgctctccgt tggcccgcag 1680
tccgtcggcc cgctctctgt tggcccgcag gctgttggcc cgctctctgt tggcccgcag 1740
tccgttggcc cgctctccgt tggcccgcag tctgttggcc cgctctccgt tggctcgcag 1800
tccgtcggcc cgctctctgt tggtccgcag tccgtcggcc cgctctccgt tggcccgcag 1860
tctgtcggcc cgctctccgt tggcccgcag tccgtcggcc cgctctccgt tggtccgcag 1920
tccgttggcc cgctctccgt tggcccgcag tccgttgacg tttctccggt gtctggatcc 1980
gaattctaa                                                         1989

<210> 23
<211> 978
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence for a KSAC fusion polypeptide.

<400> 23
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys Thr Ser Ser Ala
                85                  90                  95      
Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys
            100                 105                 110         
Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp
        115                 120                 125             
Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr
    130                 135                 140                 
Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly
145                 150                 155                 160 
Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe
                165                 170                 175     
Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly
            180                 185                 190         
Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val Gly Gly
        195                 200                 205             
Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val
    210                 215                 220                 
Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu
225                 230                 235                 240 
Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn
                245                 250                 255     
Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala
            260                 265                 270         
Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg
        275                 280                 285             
Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr
    290                 295                 300                 
Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg
305                 310                 315                 320 
Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val
                325                 330                 335     
Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp
            340                 345                 350         
Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr
        355                 360                 365             
Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr
    370                 375                 380                 
Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe
385                 390                 395                 400 
Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu
                405                 410                 415     
Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr
            420                 425                 430         
Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Gly Ser
        435                 440                 445             
Glu Pro His Lys Ala Ala Val Asp Val Gly Pro Leu Ser Val Gly Pro
    450                 455                 460                 
Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu
465                 470                 475                 480 
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala
                485                 490                 495     
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
            500                 505                 510         
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
        515                 520                 525             
Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    530                 535                 540                 
Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln
545                 550                 555                 560 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser
                565                 570                 575     
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
            580                 585                 590         
Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly
        595                 600                 605             
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    610                 615                 620                 
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
625                 630                 635                 640 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Asp Val Ser Pro
                645                 650                 655     
Val Ser Gly Ser Glu Phe Asp Ala Val Asp Trp Arg Glu Lys Gly Ala
            660                 665                 670         
Val Thr Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Ala Phe
        675                 680                 685             
Ser Ala Val Gly Asn Ile Glu Ser Gln Trp Ala Arg Ala Gly His Gly
    690                 695                 700                 
Leu Val Ser Leu Ser Glu Gln Gln Leu Val Ser Cys Asp Asp Lys Asp
705                 710                 715                 720 
Asn Gly Cys Asn Gly Gly Leu Met Leu Gln Ala Phe Glu Trp Leu Leu
                725                 730                 735     
Arg His Met Tyr Gly Ile Val Phe Thr Glu Lys Ser Tyr Pro Tyr Thr
            740                 745                 750         
Ser Gly Asn Gly Asp Val Ala Glu Cys Leu Asn Ser Ser Lys Leu Val
        755                 760                 765             
Pro Gly Ala Gln Ile Asp Gly Tyr Val Met Ile Pro Ser Asn Glu Thr
    770                 775                 780                 
Val Met Ala Ala Trp Leu Ala Glu Asn Gly Pro Ile Ala Ile Ala Val
785                 790                 795                 800 
Asp Ala Ser Ser Phe Met Ser Tyr Gln Ser Gly Val Leu Thr Ser Cys
                805                 810                 815     
Ala Gly Asp Ala Leu Asn His Gly Val Leu Leu Val Gly Tyr Asn Lys
            820                 825                 830         
Thr Gly Gly Val Pro Tyr Trp Val Ile Lys Asn Ser Trp Gly Glu Asp
        835                 840                 845             
Trp Gly Glu Lys Gly Tyr Val Arg Val Val Met Gly Leu Asn Ala Cys
    850                 855                 860                 
Leu Leu Ser Glu Tyr Pro Val Ser Ala His Val Pro Arg Ser Leu Thr
865                 870                 875                 880 
Pro Gly Pro Gly Thr Glu Ser Glu Glu Arg Ala Pro Lys Arg Val Thr
                885                 890                 895     
Val Glu Gln Met Met Cys Thr Asp Met Tyr Cys Arg Glu Gly Cys Lys
            900                 905                 910         
Lys Ser Leu Leu Thr Ala Asn Val Cys Tyr Lys Asn Gly Gly Gly Gly
        915                 920                 925             
Ser Ser Met Thr Lys Cys Gly Pro Gln Lys Val Leu Met Cys Ser Tyr
    930                 935                 940                 
Ser Asn Pro His Cys Phe Gly Pro Gly Leu Cys Leu Glu Thr Pro Asp
945                 950                 955                 960 
Gly Lys Cys Ala Pro Tyr Phe Leu Gly Ser Ile Met Asn Thr Cys Gln
                965                 970                 975     
Tyr Thr
        


<210> 24
<211> 2937
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic acid sequence encoding the KSAC fusion
      polypeptide.

<400> 24
atggccacca cgtacgagga gttttcggcg aagctggacc gcctggatga ggagttcaac 60
aggaagatgc aggagcagaa cgccaagttc tttgcggaca agccggatga gtcgacgctg 120
tcgcccgaga tgaaggagca ctacgagaag ttcgagcgca tgatcaagga acacacagag 180
aagttcaaca agaagatgca cgagcactcg gagcacttca agcagaagtt cgccgagctg 240
ctcgagcagc agaaggctgc gcagtacccg tccaagacta gttccgccgg tggccgtgag 300
accgcgccga cgaacctgat tcgtcgccgc aacaaggacg agacaaacgg ggatgtcagc 360
gccgccgccg accgcttccg cgaccgcttc gagaaggcaa ccctcgagga gcgcaaggcc 420
gccaccacga cgatggtcaa cgagtactac gacctggtga cggacttcta cgagtacggc 480
tggggccaga acttccattt cgcgccgcgc tacgccggcg agaccttctt cgagtccctc 540
gcgcgccacg agtacttcct ggccgctcgc ggcggcttca tggagggcga ccacatcgtc 600
gacgtgggct gcggcgtcgg cggtccggcg cgcaacatgg ttcgcctcac gcgctgcaac 660
gtcatcggcg tcaacaacaa cgattaccag atcagccgcg ctcgccgtca tgacgcgctc 720
gccggtatga gctccaagat cgactacgtc aagaccgact tctgcaacat gagcttagcc 780
gacaacacct tcgacggcgc ctacgccatc gaggccacct gccacgcaaa ggacaaggtc 840
aagtgctata gcgaggtctt ccgtgtcatc aagcccggca cctgctttgt cctgtacgag 900
tggtgcatga ccgacaagta caaccccaat gacgagtacc accgcacaat caagcaccgc 960
atcgagctgg gcgacggcct gccggagatg gagacgtgca aacaggtgat cgagtacatg 1020
aagcaggccg gcttcgtggt ggaggaggcc atagacgtca tcagtcagtt cgagtccagc 1080
cccatcaaga gtatcccgtg gtaccagccg ctggtcggcg actattcgtc cctgcagggc 1140
ctgcgctcta ccccgattgg ccgcatcctc acgaacgtca tgtgtcgcgt gctggagttc 1200
gtgcgcctag ctccgaaggg cacgtacaag gcgacggaga ttttggagga ggctgcggaa 1260
agcctggtgg tgggcggtca gctcggcatc ttcacgccgt ccttctacat ccgcgctcgc 1320
aagccgtcca agcaggctgg atccgagccg cacaaggcgg ccgttgacgt cggcccgctc 1380
tccgttggcc cgcagtccgt cggcccgctc tctgttggcc cgcaggctgt tggcccgctc 1440
tccgttggcc cgcagtccgt cggcccgctc tctgttggcc cgcaggctgt tggcccgctc 1500
tctgttggcc cgcagtccgt tggcccgctc tccgttggcc cgctctccgt tggcccgcag 1560
tctgttggcc cgctctccgt tggctcgcag tccgtcggcc cgctctctgt tggtccgcag 1620
tccgtcggcc cgctctccgt tggcccgcag gctgttggcc cgctctccgt tggcccgcag 1680
tccgtcggcc cgctctctgt tggcccgcag gctgttggcc cgctctctgt tggcccgcag 1740
tccgttggcc cgctctccgt tggcccgcag tctgttggcc cgctctccgt tggctcgcag 1800
tccgtcggcc cgctctctgt tggtccgcag tccgtcggcc cgctctccgt tggcccgcag 1860
tctgtcggcc cgctctccgt tggcccgcag tccgtcggcc cgctctccgt tggtccgcag 1920
tccgttggcc cgctctccgt tggcccgcag tccgttgacg tttctccggt gtctggatcc 1980
gaattcgatg cggtggactg gcgcgagaag ggcgccgtga cgccggtgaa gaatcaaggc 2040
gcgtgcgggt cgtgctgggc gttctcggcg gtcggcaaca tcgagtcgca gtgggcccgt 2100
gccggccacg gcttggtgag cctgtcggag cagcagctgg tgagctgcga tgacaaagac 2160
aatggctgca acggcgggct gatgctgcag gcgttcgagt ggctgctgcg acacatgtac 2220
gggatcgtgt tcacggagaa gagctacccc tacacgtccg gcaacggtga tgtggccgag 2280
tgcttgaaca gcagtaaact cgttcccggc gcgcaaatcg acggctacgt gatgatcccg 2340
agcaacgaaa cggttatggc tgcgtggctt gcggagaatg gccccatcgc gattgcggtc 2400
gacgccagct ccttcatgtc ttaccagagc ggcgtgctga ccagctgcgc tggcgatgca 2460
ctgaaccacg gcgtgctgct cgtcgggtac aacaagaccg gtggggttcc gtactgggtg 2520
atcaagaact cgtggggtga ggactggggc gagaagggct acgtgcgcgt ggtcatgggg 2580
ctgaacgcgt gcctgctcag tgaatacccc gtgtccgcgc atgtgccgcg gagtctcacc 2640
cctggcccgg gcacggagag cgaggagcgc gcccctaaac gggtgacggt ggagcagatg 2700
atgtgcaccg atatgtactg cagggagggg tgcaagaaga gtcttctcac cgcgaacgtg 2760
tgctacaaga acgggggagg cggctcctct atgacgaagt gcggtccgca gaaggtgctg 2820
atgtgctcgt actcgaaccc tcattgcttt ggtcctgggc tgtgcctcga gactcctgat 2880
ggcaagtgcg cgccgtactt cttgggctcg atcatgaaca cctgccagta cacgtaa    2937

<210> 25
<211> 92
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence for an immunogenic portion of
      a KMP11 polypeptide.

<400> 25
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys
                85                  90          


<210> 26
<211> 352
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence for an immunogenic portion of
      a SMP polypeptide.

<400> 26
Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg
 1               5                  10                  15      
Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe
            20                  25                  30          
Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr
        35                  40                  45              
Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu
    50                  55                  60                  
Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu
65                  70                  75                  80  
Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg
                85                  90                  95      
Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val
            100                 105                 110         
Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile
        115                 120                 125             
Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp
    130                 135                 140                 
Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe
145                 150                 155                 160 
Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile
                165                 170                 175     
Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val
            180                 185                 190         
Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys
        195                 200                 205             
Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys
    210                 215                 220                 
His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys
225                 230                 235                 240 
Gln Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala
                245                 250                 255     
Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro
            260                 265                 270         
Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg
        275                 280                 285             
Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu
    290                 295                 300                 
Glu Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile
305                 310                 315                 320 
Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile
                325                 330                 335     
Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala
            340                 345                 350         


<210> 27
<211> 210
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence for an immunogenic portion of
      an A2 polypeptide.

<400> 27
Glu Pro His Lys Ala Ala Val Asp Val Gly Pro Leu Ser Val Gly Pro
 1               5                  10                  15      
Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu
            20                  25                  30          
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala
        35                  40                  45              
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
    50                  55                  60                  
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
65                  70                  75                  80  
Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
                85                  90                  95      
Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln
            100                 105                 110         
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser
        115                 120                 125             
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
    130                 135                 140                 
Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly
145                 150                 155                 160 
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
                165                 170                 175     
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
            180                 185                 190         
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Asp Val Ser Pro
        195                 200                 205             
Val Ser
    210 


<210> 28
<211> 316
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence for an immunogenic portion of
      a CBP polypeptide.

<400> 28
Asp Ala Val Asp Trp Arg Glu Lys Gly Ala Val Thr Pro Val Lys Asn
 1               5                  10                  15      
Gln Gly Ala Cys Gly Ser Cys Trp Ala Phe Ser Ala Val Gly Asn Ile
            20                  25                  30          
Glu Ser Gln Trp Ala Arg Ala Gly His Gly Leu Val Ser Leu Ser Glu
        35                  40                  45              
Gln Gln Leu Val Ser Cys Asp Asp Lys Asp Asn Gly Cys Asn Gly Gly
    50                  55                  60                  
Leu Met Leu Gln Ala Phe Glu Trp Leu Leu Arg His Met Tyr Gly Ile
65                  70                  75                  80  
Val Phe Thr Glu Lys Ser Tyr Pro Tyr Thr Ser Gly Asn Gly Asp Val
                85                  90                  95      
Ala Glu Cys Leu Asn Ser Ser Lys Leu Val Pro Gly Ala Gln Ile Asp
            100                 105                 110         
Gly Tyr Val Met Ile Pro Ser Asn Glu Thr Val Met Ala Ala Trp Leu
        115                 120                 125             
Ala Glu Asn Gly Pro Ile Ala Ile Ala Val Asp Ala Ser Ser Phe Met
    130                 135                 140                 
Ser Tyr Gln Ser Gly Val Leu Thr Ser Cys Ala Gly Asp Ala Leu Asn
145                 150                 155                 160 
His Gly Val Leu Leu Val Gly Tyr Asn Lys Thr Gly Gly Val Pro Tyr
                165                 170                 175     
Trp Val Ile Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr
            180                 185                 190         
Val Arg Val Val Met Gly Leu Asn Ala Cys Leu Leu Ser Glu Tyr Pro
        195                 200                 205             
Val Ser Ala His Val Pro Arg Ser Leu Thr Pro Gly Pro Gly Thr Glu
    210                 215                 220                 
Ser Glu Glu Arg Ala Pro Lys Arg Val Thr Val Glu Gln Met Met Cys
225                 230                 235                 240 
Thr Asp Met Tyr Cys Arg Glu Gly Cys Lys Lys Ser Leu Leu Thr Ala
                245                 250                 255     
Asn Val Cys Tyr Lys Asn Gly Gly Gly Gly Ser Ser Met Thr Lys Cys
            260                 265                 270         
Gly Pro Gln Lys Val Leu Met Cys Ser Tyr Ser Asn Pro His Cys Phe
        275                 280                 285             
Gly Pro Gly Leu Cys Leu Glu Thr Pro Asp Gly Lys Cys Ala Pro Tyr
    290                 295                 300                 
Phe Leu Gly Ser Ile Met Asn Thr Cys Gln Tyr Thr
305                 310                 315     


<210> 29
<211> 276
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic acid sequence encoding the KMP11
      polypeptide.

<400> 29
atggccacca cgtacgagga gttttcggcg aagctggacc gcctggatga ggagttcaac 60
aggaagatgc aggagcagaa cgccaagttc tttgcggaca agccggatga gtcgacgctg 120
tcgcccgaga tgaaggagca ctacgagaag ttcgagcgca tgatcaagga acacacagag 180
aagttcaaca agaagatgca cgagcactcg gagcacttca agcagaagtt cgccgagctg 240
ctcgagcagc agaaggctgc gcagtacccg tccaag                           276

<210> 30
<211> 1056
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic acid sequence encoding the SMP
      polypeptide.

<400> 30
tccgccggtg gccgtgagac cgcgccgacg aacctgattc gtcgccgcaa caaggacgag 60
acaaacgggg atgtcagcgc cgccgccgac cgcttccgcg accgcttcga gaaggcaacc 120
ctcgaggagc gcaaggccgc caccacgacg atggtcaacg agtactacga cctggtgacg 180
gacttctacg agtacggctg gggccagaac ttccatttcg cgccgcgcta cgccggcgag 240
accttcttcg agtccctcgc gcgccacgag tacttcctgg ccgctcgcgg cggcttcatg 300
gagggcgacc acatcgtcga cgtgggctgc ggcgtcggcg gtccggcgcg caacatggtt 360
cgcctcacgc gctgcaacgt catcggcgtc aacaacaacg attaccagat cagccgcgct 420
cgccgtcatg acgcgctcgc cggtatgagc tccaagatcg actacgtcaa gaccgacttc 480
tgcaacatga gcttagccga caacaccttc gacggcgcct acgccatcga ggccacctgc 540
cacgcaaagg acaaggtcaa gtgctatagc gaggtcttcc gtgtcatcaa gcccggcacc 600
tgctttgtcc tgtacgagtg gtgcatgacc gacaagtaca accccaatga cgagtaccac 660
cgcacaatca agcaccgcat cgagctgggc gacggcctgc cggagatgga gacgtgcaaa 720
caggtgatcg agtacatgaa gcaggccggc ttcgtggtgg aggaggccat agacgtcatc 780
agtcagttcg agtccagccc catcaagagt atcccgtggt accagccgct ggtcggcgac 840
tattcgtccc tgcagggcct gcgctctacc ccgattggcc gcatcctcac gaacgtcatg 900
tgtcgcgtgc tggagttcgt gcgcctagct ccgaagggca cgtacaaggc gacggagatt 960
ttggaggagg ctgcggaaag cctggtggtg ggcggtcagc tcggcatctt cacgccgtcc 1020
ttctacatcc gcgctcgcaa gccgtccaag caggct                           1056

<210> 31
<211> 629
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic acid sequence encoding the A2 polypeptide.

<400> 31
gagccgcaca aggcggccgt tgacgtcggc ccgctctccg ttggcccgca gtccgtcggc 60
ccgctctctg ttggcccgca ggctgttggc ccgctctccg ttggcccgca gtccgtcggc 120
ccgctctctg ttggcccgca ggctgttggc ccgctctctg ttggcccgca gtccgttggc 180
ccgctctccg ttggcccgct ctccgttggc ccgcagtctg ttggcccgct ctccgttggc 240
tcgcagtccg tcggcccgct ctctgttggt ccgcagtccg tcggcccgct ctccgttggc 300
ccgcaggctg ttggcccgct ctccgttggc ccgcagtccg tcggcccgct ctctgttggc 360
ccgcaggctg ttggcccgct ctctgttggc ccgcagtccg ttggcccgct ctccgttggc 420
ccgcagtctg ttggcccgct ctccgttggc tcgcagtccg tcggcccgct ctctgttggt 480
ccgcagtccg tcggcccgct ctccgttggc ccgcagtctg tcggcccgct ctccgttggc 540
ccgcagtccg tcggcccgct ctccgttggt ccgcagtccg ttggcccgct ctccgttggc 600
ccgcagtccg ttgacgtttc tccggtgtc                                   629

<210> 32
<211> 948
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic acid sequence encoding the CBP
      polypeptide.

<400> 32
gatgcggtgg actggcgcga gaagggcgcc gtgacgccgg tgaagaatca aggcgcgtgc 60
gggtcgtgct gggcgttctc ggcggtcggc aacatcgagt cgcagtgggc ccgtgccggc 120
cacggcttgg tgagcctgtc ggagcagcag ctggtgagct gcgatgacaa agacaatggc 180
tgcaacggcg ggctgatgct gcaggcgttc gagtggctgc tgcgacacat gtacgggatc 240
gtgttcacgg agaagagcta cccctacacg tccggcaacg gtgatgtggc cgagtgcttg 300
aacagcagta aactcgttcc cggcgcgcaa atcgacggct acgtgatgat cccgagcaac 360
gaaacggtta tggctgcgtg gcttgcggag aatggcccca tcgcgattgc ggtcgacgcc 420
agctccttca tgtcttacca gagcggcgtg ctgaccagct gcgctggcga tgcactgaac 480
cacggcgtgc tgctcgtcgg gtacaacaag accggtgggg ttccgtactg ggtgatcaag 540
aactcgtggg gtgaggactg gggcgagaag ggctacgtgc gcgtggtcat ggggctgaac 600
gcgtgcctgc tcagtgaata ccccgtgtcc gcgcatgtgc cgcggagtct cacccctggc 660
ccgggcacgg agagcgagga gcgcgcccct aaacgggtga cggtggagca gatgatgtgc 720
accgatatgt actgcaggga ggggtgcaag aagagtcttc tcaccgcgaa cgtgtgctac 780
aagaacgggg gaggcggctc ctctatgacg aagtgcggtc cgcagaaggt gctgatgtgc 840
tcgtactcga accctcattg ctttggtcct gggctgtgcc tcgagactcc tgatggcaag 900
tgcgcgccgt acttcttggg ctcgatcatg aacacctgcc agtacacg              948

<210> 33
<211> 1003
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence for the KSAC fusion
      polypeptide

<400> 33
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys Thr Ser Ser Ala
                85                  90                  95      
Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys
            100                 105                 110         
Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp
        115                 120                 125             
Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr
    130                 135                 140                 
Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly
145                 150                 155                 160 
Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe
                165                 170                 175     
Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly
            180                 185                 190         
Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val Gly Gly
        195                 200                 205             
Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val
    210                 215                 220                 
Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu
225                 230                 235                 240 
Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn
                245                 250                 255     
Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala
            260                 265                 270         
Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg
        275                 280                 285             
Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr
    290                 295                 300                 
Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg
305                 310                 315                 320 
Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val
                325                 330                 335     
Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp
            340                 345                 350         
Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr
        355                 360                 365             
Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr
    370                 375                 380                 
Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe
385                 390                 395                 400 
Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu
                405                 410                 415     
Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr
            420                 425                 430         
Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Gly Ser
        435                 440                 445             
Lys Ile Arg Ser Val Arg Pro Leu Val Val Leu Leu Val Cys Val Ala
    450                 455                 460                 
Ala Val Leu Ala Leu Ser Ala Ser Ala Glu Pro His Lys Ala Ala Val
465                 470                 475                 480 
Asp Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
                485                 490                 495     
Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
            500                 505                 510         
Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly
        515                 520                 525             
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Leu Ser Val Gly Pro
    530                 535                 540                 
Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu
545                 550                 555                 560 
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala
                565                 570                 575     
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
            580                 585                 590         
Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly
        595                 600                 605             
Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser
    610                 615                 620                 
Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu
625                 630                 635                 640 
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser
                645                 650                 655     
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
            660                 665                 670         
Gly Pro Gln Ser Val Asp Val Ser Pro Val Ser Gly Ser Glu Phe Asp
        675                 680                 685             
Ala Val Asp Trp Arg Glu Lys Gly Ala Val Thr Pro Val Lys Asn Gln
    690                 695                 700                 
Gly Ala Cys Gly Ser Cys Trp Ala Phe Ser Ala Val Gly Asn Ile Glu
705                 710                 715                 720 
Ser Gln Trp Ala Arg Ala Gly His Gly Leu Val Ser Leu Ser Glu Gln
                725                 730                 735     
Gln Leu Val Ser Cys Asp Asp Lys Asp Asn Gly Cys Asn Gly Gly Leu
            740                 745                 750         
Met Leu Gln Ala Phe Glu Trp Leu Leu Arg His Met Tyr Gly Ile Val
        755                 760                 765             
Phe Thr Glu Lys Ser Tyr Pro Tyr Thr Ser Gly Asn Gly Asp Val Ala
    770                 775                 780                 
Glu Cys Leu Asn Ser Ser Lys Leu Val Pro Gly Ala Gln Ile Asp Gly
785                 790                 795                 800 
Tyr Val Met Ile Pro Ser Asn Glu Thr Val Met Ala Ala Trp Leu Ala
                805                 810                 815     
Glu Asn Gly Pro Ile Ala Ile Ala Val Asp Ala Ser Ser Phe Met Ser
            820                 825                 830         
Tyr Gln Ser Gly Val Leu Thr Ser Cys Ala Gly Asp Ala Leu Asn His
        835                 840                 845             
Gly Val Leu Leu Val Gly Tyr Asn Lys Thr Gly Gly Val Pro Tyr Trp
    850                 855                 860                 
Val Ile Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr Val
865                 870                 875                 880 
Arg Val Val Met Gly Leu Asn Ala Cys Leu Leu Ser Glu Tyr Pro Val
                885                 890                 895     
Ser Ala His Val Pro Arg Ser Leu Thr Pro Gly Pro Gly Thr Glu Ser
            900                 905                 910         
Glu Glu Arg Ala Pro Lys Arg Val Thr Val Glu Gln Met Met Cys Thr
        915                 920                 925             
Asp Met Tyr Cys Arg Glu Gly Cys Lys Lys Ser Leu Leu Thr Ala Asn
    930                 935                 940                 
Val Cys Tyr Lys Asn Gly Gly Gly Gly Ser Ser Met Thr Lys Cys Gly
945                 950                 955                 960 
Pro Gln Lys Val Leu Met Cys Ser Tyr Ser Asn Pro His Cys Phe Gly
                965                 970                 975     
Pro Gly Leu Cys Leu Glu Thr Pro Asp Gly Lys Cys Ala Pro Tyr Phe
            980                 985                 990         
Leu Gly Ser Ile Met Asn Thr Cys Gln Tyr Thr
        995                 1000            


<210> 34
<211> 3021
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic acid sequence encoding the KSAC fusion
      polypeptide

<400> 34
catatggcca ccacgtacga ggagttttcg gcgaagctgg accgcctgga tgaggagttc 60
aacaggaaga tgcaggagca gaacgccaag ttctttgcgg acaagccgga tgagtcgacg 120
ctgtcgcccg agatgaagga gcactacgag aagttcgagc gcatgatcaa ggaacacaca 180
gagaagttca acaagaagat gcacgagcac tcggagcact tcaagcagaa gttcgccgag 240
ctgctcgagc agcagaaggc tgcgcagtac ccgtccaaga ctagttccgc cggtggccgt 300
gagaccgcgc cgacgaacct gattcgtcgc cgcaacaagg acgagacaaa cggggatgtc 360
agcgccgccg ccgaccgctt ccgcgaccgc ttcgagaagg caaccctcga ggagcgcaag 420
gccgccacca cgacgatggt caacgagtac tacgacctgg tgacggactt ctacgagtac 480
ggctggggcc agaacttcca tttcgcgccg cgctacgccg gcgagacctt cttcgagtcc 540
ctcgcgcgcc acgagtactt cctggccgct cgcggcggct tcatggaggg cgaccacatc 600
gtcgacgtgg gctgcggcgt cggcggtccg gcgcgcaaca tggttcgcct cacgcgctgc 660
aacgtcatcg gcgtcaacaa caacgattac cagatcagcc gcgctcgccg tcatgacgcg 720
ctcgccggta tgagctccaa gatcgactac gtcaagaccg acttctgcaa catgagctta 780
gccgacaaca ccttcgacgg cgcctacgcc atcgaggcca cctgccacgc aaaggacaag 840
gtcaagtgct atagcgaggt cttccgtgtc atcaagcccg gcacctgctt tgtcctgtac 900
gagtggtgca tgaccgacaa gtacaacccc aatgacgagt accaccgcac aatcaagcac 960
cgcatcgagc tgggcgacgg cctgccggag atggagacgt gcaaacaggt gatcgagtac 1020
atgaagcagg ccggcttcgt ggtggaggag gccatagacg tcatcagtca gttcgagtcc 1080
agccccatca agagtatccc gtggtaccag ccgctggtcg gcgactattc gtccctgcag 1140
ggcctgcgct ctaccccgat tggccgcatc ctcacgaacg tcatgtgtcg cgtgctggag 1200
ttcgtgcgcc tagctccgaa gggcacgtac aaggcgacgg agattttgga ggaggctgcg 1260
gaaagcctgg tggtgggcgg tcagctcggc atcttcacgc cgtccttcta catccgcgct 1320
cgcaagccgt ccaagcaggc tggatccaag atccgcagcg tgcgtccgct tgtggtgttg 1380
ctggtgtgcg tcgcggcggt gctcgcactc agcgcctccg ctgagccgca caaggcggcc 1440
gttgacgtcg gcccgctgag cgttggcccg cagagcgtcg gcccgctgag cgttggcccg 1500
caggcggttg gcccgctgag cgttggcccg cagagcgtcg gcccgctgag cgttggcccg 1560
caggcggttg gcccgctgag cgttggcccg cagagcgttg gcccgctgag cgttggcccg 1620
ctgagcgttg gcccgcagag cgttggcccg ctgagcgttg gcagccagag cgtcggcccg 1680
ctgagcgttg gtccgcagag cgtcggcccg ctgagcgttg gcccgcaggc ggttggcccg 1740
ctgagcgttg gcccgcagag cgtcggcccg ctgagcgttg gcccgcaggc ggttggcccg 1800
ctgagcgttg gcccgcagag cgttggcccg ctgagcgttg gcccgcagag cgttggcccg 1860
ctgagcgttg gcagccagag cgtcggcccg ctgagcgttg gtccgcagag cgtcggcccg 1920
ctgagcgttg gcccgcagag cgtcggcccg ctgagcgttg gcccgcagag cgtcggcccg 1980
ctgagcgttg gtccgcagag cgttggcccg ctgagcgttg gcccgcagag cgttgacgtt 2040
agcccggtga gcggatccga attcgatgcg gtggactggc gcgagaaggg cgccgtgacg 2100
ccggtgaaga atcaaggcgc gtgcgggtcg tgctgggcgt tctcggcggt cggcaacatc 2160
gagtcgcagt gggcccgtgc cggccacggc ttggtgagcc tgtcggagca gcagctggtg 2220
agctgcgatg acaaagacaa tggctgcaac ggcgggctga tgctgcaggc gttcgagtgg 2280
ctgctgcgac acatgtacgg gatcgtgttc acggagaaga gctaccccta cacgtccggc 2340
aacggtgatg tggccgagtg cttgaacagc agtaaactcg ttcccggcgc gcaaatcgac 2400
ggctacgtga tgatcccgag caacgaaacg gttatggctg cgtggcttgc ggagaatggc 2460
cccatcgcga ttgcggtcga cgccagctcc ttcatgtctt accagagcgg cgtgctgacc 2520
agctgcgctg gcgatgcact gaaccacggc gtgctgctcg tcgggtacaa caagaccggt 2580
ggggttccgt actgggtgat caagaactcg tggggtgagg actggggcga gaagggctac 2640
gtgcgcgtgg tcatggggct gaacgcgtgc ctgctcagtg aataccccgt gtccgcgcat 2700
gtgccgcgga gtctcacccc tggcccgggc acggagagcg aggagcgcgc ccctaaacgg 2760
gtgacggtgg agcagatgat gtgcaccgat atgtactgca gggaggggtg caagaagagt 2820
cttctcaccg cgaacgtgtg ctacaagaac gggggaggcg gctcctctat gacgaagtgc 2880
ggtccgcaga aggtgctgat gtgctcgtac tcgaaccctc attgctttgg tcctgggctg 2940
tgcctcgaga ctcctgatgg caagtgcgcg ccgtacttct tgggctcgat catgaacacc 3000
tgccagtaca cgtaaaagct t                                           3021

<210> 35
<211> 660
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence for a KSA (no Cys) fusion
      polypeptide

<400> 35
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys Thr Ser Ser Ala
                85                  90                  95      
Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys
            100                 105                 110         
Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp
        115                 120                 125             
Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr
    130                 135                 140                 
Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly
145                 150                 155                 160 
Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe
                165                 170                 175     
Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly
            180                 185                 190         
Phe Met Glu Gly Asp His Ile Val Asp Val Gly Ser Gly Val Gly Gly
        195                 200                 205             
Pro Ala Arg Asn Met Val Arg Leu Thr Arg Ser Asn Val Ile Gly Val
    210                 215                 220                 
Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu
225                 230                 235                 240 
Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Ser Asn
                245                 250                 255     
Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala
            260                 265                 270         
Thr Ser His Ala Lys Asp Lys Val Lys Ser Tyr Ser Glu Val Phe Arg
        275                 280                 285             
Val Ile Lys Pro Gly Thr Ser Phe Val Leu Tyr Glu Trp Ser Met Thr
    290                 295                 300                 
Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg
305                 310                 315                 320 
Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Ser Lys Gln Val
                325                 330                 335     
Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp
            340                 345                 350         
Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr
        355                 360                 365             
Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr
    370                 375                 380                 
Pro Ile Gly Arg Ile Leu Thr Asn Val Met Ser Arg Val Leu Glu Phe
385                 390                 395                 400 
Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu
                405                 410                 415     
Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr
            420                 425                 430         
Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Gly Ser
        435                 440                 445             
Glu Pro His Lys Ala Ala Val Asp Val Gly Pro Leu Ser Val Gly Pro
    450                 455                 460                 
Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu
465                 470                 475                 480 
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala
                485                 490                 495     
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
            500                 505                 510         
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
        515                 520                 525             
Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    530                 535                 540                 
Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln
545                 550                 555                 560 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser
                565                 570                 575     
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
            580                 585                 590         
Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly
        595                 600                 605             
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    610                 615                 620                 
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
625                 630                 635                 640 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Asp Val Ser Pro
                645                 650                 655     
Val Ser Gly Ser
            660 


<210> 36
<211> 1990
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleotide sequence of KSA (no cys) Cloned in
      NdeI/EcoRI in pET29

<400> 36
catatggcca ccacgtacga ggagtttagc gcgaagctgg accgcctgga tgaggagttc 60
aaccgcaaga tgcaggagca gaacgccaag ttctttgcgg acaagccgga tgagagcacg 120
ctgagcccgg agatgaagga gcactacgag aagttcgagc gcatgatcaa ggaacacacc 180
gagaagttca acaagaagat gcacgagcac agcgagcact tcaagcagaa gttcgccgag 240
ctgctggagc agcagaaggc ggcgcagtac ccgagcaaga ctagtagcgc cggtggccgt 300
gagaccgcgc cgacgaacct gattcgtcgc cgcaacaagg acgagaccaa cggcgatgtc 360
agcgccgccg ccgaccgctt ccgcgaccgc ttcgagaagg caaccctgga ggagcgcaag 420
gccgccacca cgacgatggt caacgagtac tacgacctgg tgacggactt ctacgagtac 480
ggctggggcc agaacttcca tttcgcgccg cgctacgccg gcgagacctt cttcgagagc 540
ctggcgcgcc acgagtactt cctggccgcg cgcggcggct tcatggaggg cgaccacatc 600
gtcgacgtgg gcagcggcgt cggcggtccg gcgcgcaaca tggttcgcct gacgcgcagc 660
aacgtcatcg gcgtcaacaa caacgattac cagatcagcc gcgcgcgccg tcatgacgcg 720
ctggccggta tgagcagcaa gatcgactac gtcaagaccg acttcagcaa catgagcctg 780
gccgacaaca ccttcgacgg cgcctacgcc atcgaggcca ccagccacgc aaaggacaag 840
gtcaagagct atagcgaggt cttccgtgtc atcaagccgg gcaccagctt tgtcctgtac 900
gagtggagca tgaccgacaa gtacaacccg aatgacgagt accaccgcac catcaagcac 960
cgcatcgagc tgggcgacgg cctgccggag atggagacga gcaaacaggt gatcgagtac 1020
atgaagcagg ccggcttcgt ggtggaggag gccattgacg tcatcagcca gttcgagagc 1080
agcccgatca agagcatccc gtggtaccag ccgctggtcg gcgactatag cagcctgcag 1140
ggcctgcgca gcaccccgat tggccgcatc ctgacgaacg tcatgagccg cgtgctggag 1200
ttcgtgcgcc tggcgccgaa gggcacgtac aaggcgacgg agattctgga ggaggcggcg 1260
gaaagcctgg tggtgggcgg tcagctgggc atcttcacgc cgagcttcta catccgcgcg 1320
cgcaagccga gcaagcaggc gggatccgag ccgcacaagg cggccgttga cgtcggcccg 1380
ctgagcgttg gcccgcagag cgtcggcccg ctgagcgttg gcccgcaggc ggttggcccg 1440
ctgagcgttg gcccgcagag cgtcggcccg ctgagcgttg gcccgcaggc ggttggcccg 1500
ctgagcgttg gcccgcagag cgttggcccg ctgagcgttg gcccgctgag cgttggcccg 1560
cagagcgttg gcccgctgag cgttggcagc cagagcgtcg gcccgctgag cgttggtccg 1620
cagagcgtcg gcccgctgag cgttggcccg caggcggttg gcccgctgag cgttggcccg 1680
cagagcgtcg gcccgctgag cgttggcccg caggcggttg gcccgctgag cgttggcccg 1740
cagagcgttg gcccgctgag cgttggcccg cagagcgttg gcccgctgag cgttggcagc 1800
cagagcgtcg gcccgctgag cgttggtccg cagagcgtcg gcccgctgag cgttggcccg 1860
cagagcgtcg gcccgctgag cgttggcccg cagagcgtcg gcccgctgag cgttggtccg 1920
cagagcgttg gcccgctgag cgttggcccg cagagcgttg acgttagccc ggtgagcgga 1980
tcctgaattc                                                        1990

<210> 37
<211> 978
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino acid sequence of original KSAC (no cys)
      polyprotein fusion

<400> 37
Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp
 1               5                  10                  15      
Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala
            20                  25                  30          
Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr
        35                  40                  45              
Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys
    50                  55                  60                  
Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu
65                  70                  75                  80  
Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys Thr Ser Ser Ala
                85                  90                  95      
Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys
            100                 105                 110         
Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp
        115                 120                 125             
Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr
    130                 135                 140                 
Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly
145                 150                 155                 160 
Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe
                165                 170                 175     
Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly
            180                 185                 190         
Phe Met Glu Gly Asp His Ile Val Asp Val Gly Ser Gly Val Gly Gly
        195                 200                 205             
Pro Ala Arg Asn Met Val Arg Leu Thr Arg Ser Asn Val Ile Gly Val
    210                 215                 220                 
Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu
225                 230                 235                 240 
Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Ser Asn
                245                 250                 255     
Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala
            260                 265                 270         
Thr Ser His Ala Lys Asp Lys Val Lys Ser Tyr Ser Glu Val Phe Arg
        275                 280                 285             
Val Ile Lys Pro Gly Thr Ser Phe Val Leu Tyr Glu Trp Ser Met Thr
    290                 295                 300                 
Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg
305                 310                 315                 320 
Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Ser Lys Gln Val
                325                 330                 335     
Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp
            340                 345                 350         
Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr
        355                 360                 365             
Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr
    370                 375                 380                 
Pro Ile Gly Arg Ile Leu Thr Asn Val Met Ser Arg Val Leu Glu Phe
385                 390                 395                 400 
Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu
                405                 410                 415     
Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr
            420                 425                 430         
Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Gly Ser
        435                 440                 445             
Glu Pro His Lys Ala Ala Val Asp Val Gly Pro Leu Ser Val Gly Pro
    450                 455                 460                 
Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu
465                 470                 475                 480 
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala
                485                 490                 495     
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
            500                 505                 510         
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
        515                 520                 525             
Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    530                 535                 540                 
Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln
545                 550                 555                 560 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser
                565                 570                 575     
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
            580                 585                 590         
Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly
        595                 600                 605             
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    610                 615                 620                 
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
625                 630                 635                 640 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Asp Val Ser Pro
                645                 650                 655     
Val Ser Gly Ser Glu Phe Asp Ala Val Asp Trp Arg Glu Lys Gly Ala
            660                 665                 670         
Val Thr Pro Val Lys Asn Gln Gly Ala Ser Gly Ser Ser Trp Ala Phe
        675                 680                 685             
Ser Ala Val Gly Asn Ile Glu Ser Gln Trp Ala Arg Ala Gly His Gly
    690                 695                 700                 
Leu Val Ser Leu Ser Glu Gln Gln Leu Val Ser Ser Asp Asp Lys Asp
705                 710                 715                 720 
Asn Gly Ser Asn Gly Gly Leu Met Leu Gln Ala Phe Glu Trp Leu Leu
                725                 730                 735     
Arg His Met Tyr Gly Ile Val Phe Thr Glu Lys Ser Tyr Pro Tyr Thr
            740                 745                 750         
Ser Gly Asn Gly Asp Val Ala Glu Ser Leu Asn Ser Ser Lys Leu Val
        755                 760                 765             
Pro Gly Ala Gln Ile Asp Gly Tyr Val Met Ile Pro Ser Asn Glu Thr
    770                 775                 780                 
Val Met Ala Ala Trp Leu Ala Glu Asn Gly Pro Ile Ala Ile Ala Val
785                 790                 795                 800 
Asp Ala Ser Ser Phe Met Ser Tyr Gln Ser Gly Val Leu Thr Ser Ser
                805                 810                 815     
Ala Gly Asp Ala Leu Asn His Gly Val Leu Leu Val Gly Tyr Asn Lys
            820                 825                 830         
Thr Gly Gly Val Pro Tyr Trp Val Ile Lys Asn Ser Trp Gly Glu Asp
        835                 840                 845             
Trp Gly Glu Lys Gly Tyr Val Arg Val Val Met Gly Leu Asn Ala Ser
    850                 855                 860                 
Leu Leu Ser Glu Tyr Pro Val Ser Ala His Val Pro Arg Ser Leu Thr
865                 870                 875                 880 
Pro Gly Pro Gly Thr Glu Ser Glu Glu Arg Ala Pro Lys Arg Val Thr
                885                 890                 895     
Val Glu Gln Met Met Ser Thr Asp Met Tyr Ser Arg Glu Gly Ser Lys
            900                 905                 910         
Lys Ser Leu Leu Thr Ala Asn Val Ser Tyr Lys Asn Gly Gly Gly Gly
        915                 920                 925             
Ser Ser Met Thr Lys Ser Gly Pro Gln Lys Val Leu Met Ser Ser Tyr
    930                 935                 940                 
Ser Asn Pro His Ser Phe Gly Pro Gly Leu Ser Leu Glu Thr Pro Asp
945                 950                 955                 960 
Gly Lys Ser Ala Pro Tyr Phe Leu Gly Ser Ile Met Asn Thr Ser Gln
                965                 970                 975     
Tyr Thr
        


<210> 38
<211> 2946
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleotide sequence of original KSAC (no cys)
      Cloned in NdeI/HindIII in pET29

<400> 38
catatggcca ccacgtacga ggagtttagc gcgaagctgg accgcctgga tgaggagttc 60
aaccgcaaga tgcaggagca gaacgccaag ttctttgcgg acaagccgga tgagagcacg 120
ctgagcccgg agatgaagga gcactacgag aagttcgagc gcatgatcaa ggaacacacc 180
gagaagttca acaagaagat gcacgagcac agcgagcact tcaagcagaa gttcgccgag 240
ctgctggagc agcagaaggc ggcgcagtac ccgagcaaga ctagtagcgc cggtggccgt 300
gagaccgcgc cgacgaacct gattcgtcgc cgcaacaagg acgagaccaa cggcgatgtc 360
agcgccgccg ccgaccgctt ccgcgaccgc ttcgagaagg caaccctgga ggagcgcaag 420
gccgccacca cgacgatggt caacgagtac tacgacctgg tgacggactt ctacgagtac 480
ggctggggcc agaacttcca tttcgcgccg cgctacgccg gcgagacctt cttcgagagc 540
ctggcgcgcc acgagtactt cctggccgcg cgcggcggct tcatggaggg cgaccacatc 600
gtcgacgtgg gcagcggcgt cggcggtccg gcgcgcaaca tggttcgcct gacgcgcagc 660
aacgtcatcg gcgtcaacaa caacgattac cagatcagcc gcgcgcgccg tcatgacgcg 720
ctggccggta tgagcagcaa gatcgactac gtcaagaccg acttcagcaa catgagcctg 780
gccgacaaca ccttcgacgg cgcctacgcc atcgaggcca ccagccacgc aaaggacaag 840
gtcaagagct atagcgaggt cttccgtgtc atcaagccgg gcaccagctt tgtcctgtac 900
gagtggagca tgaccgacaa gtacaacccg aatgacgagt accaccgcac catcaagcac 960
cgcatcgagc tgggcgacgg cctgccggag atggagacga gcaaacaggt gatcgagtac 1020
atgaagcagg ccggcttcgt ggtggaggag gccattgacg tcatcagcca gttcgagagc 1080
agcccgatca agagcatccc gtggtaccag ccgctggtcg gcgactatag cagcctgcag 1140
ggcctgcgca gcaccccgat tggccgcatc ctgacgaacg tcatgagccg cgtgctggag 1200
ttcgtgcgcc tggcgccgaa gggcacgtac aaggcgacgg agattctgga ggaggcggcg 1260
gaaagcctgg tggtgggcgg tcagctgggc atcttcacgc cgagcttcta catccgcgcg 1320
cgcaagccga gcaagcaggc gggatccgag ccgcacaagg cggccgttga cgtcggcccg 1380
ctgagcgttg gcccgcagag cgtcggcccg ctgagcgttg gcccgcaggc ggttggcccg 1440
ctgagcgttg gcccgcagag cgtcggcccg ctgagcgttg gcccgcaggc ggttggcccg 1500
ctgagcgttg gcccgcagag cgttggcccg ctgagcgttg gcccgctgag cgttggcccg 1560
cagagcgttg gcccgctgag cgttggcagc cagagcgtcg gcccgctgag cgttggtccg 1620
cagagcgtcg gcccgctgag cgttggcccg caggcggttg gcccgctgag cgttggcccg 1680
cagagcgtcg gcccgctgag cgttggcccg caggcggttg gcccgctgag cgttggcccg 1740
cagagcgttg gcccgctgag cgttggcccg cagagcgttg gcccgctgag cgttggcagc 1800
cagagcgtcg gcccgctgag cgttggtccg cagagcgtcg gcccgctgag cgttggcccg 1860
cagagcgtcg gcccgctgag cgttggcccg cagagcgtcg gcccgctgag cgttggtccg 1920
cagagcgttg gcccgctgag cgttggcccg cagagcgttg acgttagccc ggtgagcgga 1980
tccgaattcg atgcggtgga ctggcgcgag aagggcgccg tgacgccggt gaagaatcaa 2040
ggcgcgagcg gcagcagctg ggcgttcagc gcggtcggca acatcgagag ccagtgggcc 2100
cgtgccggcc acggcctggt gagcctgagc gagcagcagc tggtgagcag cgatgacaaa 2160
gacaatggca gcaacggcgg cctgatgctg caggcgttcg agtggctgct gcgccacatg 2220
tacggcatcg tgttcacgga gaagagctac ccgtacacga gcggcaacgg tgatgtggcc 2280
gagagcctga acagcagcaa actggttccg ggcgcgcaaa tcgacggcta cgtgatgatc 2340
ccgagcaacg aaacggttat ggcggcgtgg ctggcggaga atggcccgat cgcgattgcg 2400
gtcgacgcca gcagcttcat gagctaccag agcggcgtgc tgaccagcag cgcgggcgat 2460
gcactgaacc acggcgtgct gctggtcggc tacaacaaga ccggtggcgt tccgtactgg 2520
gtgatcaaga acagctgggg tgaggactgg ggcgagaagg gctacgtgcg cgtggtcatg 2580
ggcctgaacg cgagcctgct gagcgaatac ccggtgagcg cgcatgtgcc gcgcagcctg 2640
accccgggcc cgggcacgga gagcgaggag cgcgccccga aacgcgtgac ggtggagcag 2700
atgatgagca ccgatatgta cagccgcgag ggcagcaaga agagcctgct gaccgcgaac 2760
gtgagctaca agaacggcgg cggcggcagc agcatgacga agagcggtcc gcagaaggtg 2820
ctgatgagca gctacagcaa cccgcatagc tttggtccgg gcctgagcct ggagaccccg 2880
gatggcaaga gcgcgccgta cttcctgggc agcatcatga acaccagcca gtacacgtaa 2940
aagctt                                                            2946

