
                                SEQUENCE LISTING

<110> STEWART, Dennis R.

<120> METHOD OF PREVENTING PREMATURE DELIVERY

<130> 64325-2001240

<140> PCT/US2009/044251    
<141> 2009-05-15  

<150> US 61/127,888       
<151> 2008-05-16  

<160> 8

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1
Asp Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val
 1               5                  10                  15      
Arg Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser
            20                  25                  


<210> 2
<211> 24
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(24)
<223> Xaa = Glu or Gln

<400> 2
Xaa Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr
 1               5                  10                  15      
Lys Arg Ser Leu Ala Arg Phe Cys
            20                  


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Relaxin consensus sequence

<221> VARIANT        
<222> (1)...(8)
<223> Xaa = Any Amino Acid

<400> 3
Arg Glu Leu Val Arg Xaa Xaa Ile
 1               5              


<210> 4
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<221> VARIANT        
<222> 1
<223> Xaa = Absent or Gly or a small naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 2
<223> Xaa = Absent or Gln or a polar naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 3
<223> Xaa = Absent or Lys or a basic naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 4
<223> Xaa = Absent or Gly or a small naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 5
<223> Xaa = Absent or Gln or Ser or a polar naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 6
<223> Xaa = Absent or Val or Ala or Pro or Met or 
a hydrophobic naturally or non-naturally occurring amino acid

<221> VARIANT        
<222> 7
<223> Xaa = Absent or Gly or a small naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 8
<223> Xaa = Absent or Pro or Leu or Ala or a naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 9
<223> Xaa = Absent or Pro or Gln or a naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 10
<223> Xaa = Absent or Gly or a small naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 11
<223> Xaa = Absent or Ala or His or Glu or Asp or 
a hydrophobic or a small or an acidic naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 12
<223> Xaa = Absent or Ala or Pro or Gln or Ser or Arg or 
His or a hydrophobic or a small naturally or non- naturally 
occurring amino acid

<221> VARIANT        
<222> 13
<223> Xaa = Absent or Cys or Val or a hydrophobic naturally or 
non-naturally 
occurring amino acid

<221> VARIANT        
<222> 14
<223> Xaa = Absent or Arg or Lys or Gln or Pro or a basic or 
a polar naturally or non-naturally occurring amino acid

<221> VARIANT        
<222> 15
<223> Xaa = Absent or Arg or Gln or Ser or a basic or a polar 
naturally or non-naturally occurring amino acid

<221> VARIANT        
<222> 16
<223> Xaa = Absent or Ala or Leu or His or Gln or a hydrophobic 
or a small naturally or non-naturally occurring amino acid

<221> VARIANT        
<222> 17
<223> Xaa = Absent or Tyr or a hydrophobic or an aromatic 
naturally or non-naturally occurring amino acid

<221> VARIANT        
<222> 18
<223> Xaa = Absent or Ala or a hydrophobic or small naturally 
or non-naturally occurring amino acid

<221> VARIANT        
<222> 19
<223> Xaa = Absent or Ala or a hydrophobic small naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 20
<223> Xaa = Absent or Phe or a hydrophobic or an aromatic 
naturally or non-naturally occurring amino acid

<221> VARIANT        
<222> 21
<223> Xaa = Absent or Ser or Thr or a polar naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 22
<223> Xaa = Absent or Val or a hydrophobic naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 23
<223> Xaa = Absent or Gly or hydrophobic or small non-naturally 
occurring amino acid or replaced by an amide

<221> VARIANT        
<222> 24
<223> Xaa = Absent or Arg or a basic naturally or non-naturally 
occurring amino acid

<221> VARIANT        
<222> 25
<223> Xaa = Absent or Arg or a basic naturally or non-naturally 
occurring amino acid

<221> VARIANT        
<222> 26
<223> Xaa = Ala or a hydrophobic or small naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 27
<223> Xaa = Tyr or a hydrophobic or an aromatic naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 28
<223> Xaa = Ala or a hydrophobic or small naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 29
<223> Xaa = Ala or a hydrophobic or small naturally or 
non-naturally occurring amino acid

<221> VARIANT        
<222> 30
<223> Xaa = Phe or a hydrophobic naturally or non-naturally 
occurring amino acid

<221> VARIANT        
<222> 31
<223> Xaa = Ser or Thr or a polar naturally or non-naturally 
occurring amino acid

<221> VARIANT        
<222> 32
<223> Xaa = Val or a hydrophobic naturally or non-naturally 
occurring amino acid

<221> VARIANT        
<222> 33
<223> Xaa = Absent or Gly or hydrophobic or small naturally 
or non-naturally occurring amino acid or replaced by an amide

<400> 4
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 5
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5
Gly Gln Lys Gly Gln Val Gly Pro Pro Gly Ala Ala Val Arg Arg Ala
 1               5                  10                  15      
Tyr Ala Ala Phe Ser Val
            20          


<210> 6
<211> 32
<212> PRT
<213> Homo sapiens

<400> 6
Gly Gln Lys Gly Gln Val Gly Pro Pro Gly Ala Ala Val Arg Arg Ala
 1               5                  10                  15      
Tyr Ala Ala Phe Ser Val Gly Arg Arg Ala Tyr Ala Ala Phe Ser Val
            20                  25                  30          


<210> 7
<211> 23
<212> PRT
<213> Homo sapiens

<400> 7
Gly Gln Lys Gly Gln Val Gly Pro Pro Gly Ala Ala Cys Arg Arg Ala
 1               5                  10                  15      
Tyr Ala Ala Phe Ser Val Gly
            20              


<210> 8
<211> 262
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Ala Pro Ala Leu Leu Leu Leu Ala Leu Leu Leu Pro Val Gly
 1               5                  10                  15      
Ala Trp Pro Gly Leu Pro Arg Arg Pro Cys Val His Cys Cys Arg Pro
            20                  25                  30          
Ala Trp Pro Pro Gly Pro Tyr Ala Arg Val Ser Asp Arg Asp Leu Trp
        35                  40                  45              
Arg Gly Asp Leu Trp Arg Gly Leu Pro Arg Val Arg Pro Thr Ile Asp
    50                  55                  60                  
Ile Glu Ile Leu Lys Gly Glu Lys Gly Glu Ala Gly Val Arg Gly Arg
65                  70                  75                  80  
Ala Gly Arg Ser Gly Lys Glu Gly Pro Pro Gly Ala Arg Gly Leu Gln
                85                  90                  95      
Gly Arg Arg Gly Gln Lys Gly Gln Val Gly Pro Pro Gly Ala Ala Cys
            100                 105                 110         
Arg Arg Ala Tyr Ala Ala Phe Ser Val Gly Arg Arg Ala Tyr Ala Ala
        115                 120                 125             
Phe Ser Val Gly Arg Arg Glu Gly Leu His Ser Ser Asp His Phe Gln
    130                 135                 140                 
Ala Val Pro Phe Asp Thr Glu Leu Val Asn Leu Asp Gly Ala Phe Asp
145                 150                 155                 160 
Leu Ala Ala Gly Arg Phe Leu Cys Thr Val Pro Gly Val Tyr Phe Leu
                165                 170                 175     
Ser Leu Asn Val His Thr Trp Asn Tyr Lys Glu Thr Tyr Leu His Ile
            180                 185                 190         
Met Leu Asn Arg Arg Pro Ala Ala Val Leu Tyr Ala Gln Pro Ser Glu
        195                 200                 205             
Arg Ser Val Met Gln Ala Gln Ser Leu Met Leu Leu Leu Ala Ala Gly
    210                 215                 220                 
Asp Ala Val Trp Val Arg Met Phe Gln Arg Asp Arg Asp Asn Ala Ile
225                 230                 235                 240 
Tyr Gly Glu His Gly Asp Leu Tyr Ile Thr Phe Ser Gly His Leu Val
                245                 250                 255     
Lys Pro Ala Ala Glu Leu
            260         

