                               SEQUENCE LISTING

<110> GENENTECH, INC.
 
<120> AFFINITY MATURED CRIG VARIANTS

<130> GNE-0322PCT

<140> Not yet Assigned
<141> Herewith

<150> 61/189,653
<151> 2008-08-20

<150> 61/050,888
<151> 2008-05-06

<160> 67   

<170> PatentIn version 3.5

<210> 1
<211> 1372
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (65)..(1261)

<400> 1
ccaactgcac ctcggttcta tcgataggag gctggaagaa aggacagaag tagctctggc       60

tgtg atg ggg atc tta ctg ggc ctg cta ctc ctg ggg cac cta aca gtg       109
     Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val          
     1               5                   10                  15           

gac act tat ggc cgt ccc atc ctg gaa gtg cca gag agt gta aca gga        157
Asp Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly           
                20                  25                  30                

cct tgg aaa ggg gat gtg aat ctt ccc tgc acc tat gac ccc ctg caa        205
Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln           
            35                  40                  45                    

ggc tac acc caa gtc ttg gtg aag tgg ctg gta caa cgt ggc tca gac        253
Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp           
        50                  55                  60                        

cct gtc acc atc ttt cta cgt gac tct tct gga gac cat atc cag cag        301
Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln           
    65                  70                  75                            

gca aag tac cag ggc cgc ctg cat gtg agc cac aag gtt cca gga gat        349
Ala Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp           
80                  85                  90                  95            

gta tcc ctc caa ttg agc acc ctg gag atg gat gac cgg agc cac tac        397
Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr           
                100                 105                 110               

acg tgt gaa gtc acc tgg cag act cct gat ggc aac caa gtc gtg aga        445
Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg           
            115                 120                 125                   

gat aag att act gag ctc cgt gtc cag aaa ctc tct gtc tcc aag ccc        493
Asp Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro           
        130                 135                 140                       

aca gtg aca act ggc agc ggt tat ggc ttc acg gtg ccc cag gga atg        541
Thr Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met           
    145                 150                 155                           

agg att agc ctt caa tgc cag gct cgg ggt tct cct ccc atc agt tat        589
Arg Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr           
160                 165                 170                 175           

att tgg tat aag caa cag act aat aac cag gaa ccc atc aaa gta gca        637
Ile Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala           
                180                 185                 190               

acc cta agt acc tta ctc ttc aag cct gcg gtg ata gcc gac tca ggc        685
Thr Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly           
            195                 200                 205                   

tcc tat ttc tgc act gcc aag ggc cag gtt ggc tct gag cag cac agc        733
Ser Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser           
        210                 215                 220                       

gac att gtg aag ttt gtg gtc aaa gac tcc tca aag cta ctc aag acc        781
Asp Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr           
    225                 230                 235                           

aag act gag gca cct aca acc atg aca tac ccc ttg aaa gca aca tct        829
Lys Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser           
240                 245                 250                 255           

aca gtg aag cag tcc tgg gac tgg acc act gac atg gat ggc tac ctt        877
Thr Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu           
                260                 265                 270               

gga gag acc agt gct ggg cca gga aag agc ctg cct gtc ttt gcc atc        925
Gly Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile           
            275                 280                 285                   

atc ctc atc atc tcc ttg tgc tgt atg gtg gtt ttt acc atg gcc tat        973
Ile Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr           
        290                 295                 300                       

atc atg ctc tgt cgg aag aca tcc caa caa gag cat gtc tac gaa gca       1021
Ile Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala           
    305                 310                 315                           

gcc agg gca cat gcc aga gag gcc aac gac tct gga gaa acc atg agg       1069
Ala Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg           
320                 325                 330                 335           

gtg gcc atc ttc gca agt ggc tgc tcc agt gat gag cca act tcc cag       1117
Val Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln           
                340                 345                 350               

aat ctg ggc aac aac tac tct gat gag ccc tgc ata gga cag gag tac       1165
Asn Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr           
            355                 360                 365                   

cag atc atc gcc cag atc aat ggc aac tac gcc cgc ctg ctg gac aca       1213
Gln Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr           
        370                 375                 380                       

gtt cct ctg gat tat gag ttt ctg gcc act gag ggc aaa agt gtc tgt       1261
Val Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys           
    385                 390                 395                           

taaaaatgcc ccattaggcc aggatctgct gacataatct agagtcgacc tgcagaagct     1321

tggccgccat ggcccaactt gtttattgca gcttataatg gttacaaata a              1372


<210> 2
<211> 399
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     


Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         


Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             


Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 


Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 


<210> 3
<211> 1090
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (67)..(981)

<400> 3
gtccaactgc acctcggttc tatcgatagg aggctggaag aaaggacaga agtagctctg       60

gctgtg atg ggg atc tta ctg ggc ctg cta ctc ctg ggg cac cta aca         108
       Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr            
       1               5                   10                             

gtg gac act tat ggc cgt ccc atc ctg gaa gtg cca gag agt gta aca        156
Val Asp Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr           
15                  20                  25                  30            

gga cct tgg aaa ggg gat gtg aat ctt ccc tgc acc tat gac ccc ctg        204
Gly Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu           
                35                  40                  45                

caa ggc tac acc caa gtc ttg gtg aag tgg ctg gta caa cgt ggc tca        252
Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser           
            50                  55                  60                    

gac cct gtc acc atc ttt cta cgt gac tct tct gga gac cat atc cag        300
Asp Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln           
        65                  70                  75                        

cag gca aag tac cag ggc cgc ctg cat gtg agc cac aag gtt cca gga        348
Gln Ala Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly           
    80                  85                  90                            

gat gta tcc ctc caa ttg agc acc ctg gag atg gat gac cgg agc cac        396
Asp Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His           
95                  100                 105                 110           

tac acg tgt gaa gtc acc tgg cag act cct gat ggc aac caa gtc gtg        444
Tyr Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val           
                115                 120                 125               

aga gat aag att act gag ctc cgt gtc cag aaa cac tcc tca aag cta        492
Arg Asp Lys Ile Thr Glu Leu Arg Val Gln Lys His Ser Ser Lys Leu           
            130                 135                 140                   

ctc aag acc aag act gag gca cct aca acc atg aca tac ccc ttg aaa        540
Leu Lys Thr Lys Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys           
        145                 150                 155                       

gca aca tct aca gtg aag cag tcc tgg gac tgg acc act gac atg gat        588
Ala Thr Ser Thr Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp           
    160                 165                 170                           

ggc tac ctt gga gag acc agt gct ggg cca gga aag agc ctg cct gtc        636
Gly Tyr Leu Gly Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val           
175                 180                 185                 190           

ttt gcc atc atc ctc atc atc tcc ttg tgc tgt atg gtg gtt ttt acc        684
Phe Ala Ile Ile Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr           
                195                 200                 205               

atg gcc tat atc atg ctc tgt cgg aag aca tcc caa caa gag cat gtc        732
Met Ala Tyr Ile Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val           
            210                 215                 220                   

tac gaa gca gcc agg gca cat gcc aga gag gcc aac gac tct gga gaa        780
Tyr Glu Ala Ala Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu           
        225                 230                 235                       

acc atg agg gtg gcc atc ttc gca agt ggc tgc tcc agt gat gag cca        828
Thr Met Arg Val Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro           
    240                 245                 250                           

act tcc cag aat ctg ggc aac aac tac tct gat gag ccc tgc ata gga        876
Thr Ser Gln Asn Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly           
255                 260                 265                 270           

cag gag tac cag atc atc gcc cag atc aat ggc aac tac gcc cgc ctg        924
Gln Glu Tyr Gln Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu           
                275                 280                 285               

ctg gac aca gtt cct ctg gat tat gag ttt ctg gcc act gag ggc aaa        972
Leu Asp Thr Val Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys           
            290                 295                 300                   

agt gtc tgt taaaaatgcc ccattaggcc aggatctgct gacataatct               1021
Ser Val Cys                                                               
        305                                                               

agagtcgacc tgcagaagct tggccgccat ggcccaactt gtttattgca gcttataatg     1081

gttacaata                                                             1090


<210> 4
<211> 305
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys His Ser Ser Lys Leu Leu Lys 
    130                 135                 140                 


Thr Lys Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr 
145                 150                 155                 160 


Ser Thr Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr 
                165                 170                 175     


Leu Gly Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala 
            180                 185                 190         


Ile Ile Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala 
        195                 200                 205             


Tyr Ile Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu 
    210                 215                 220                 


Ala Ala Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met 
225                 230                 235                 240 


Arg Val Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser 
                245                 250                 255     


Gln Asn Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu 
            260                 265                 270         


Tyr Gln Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp 
        275                 280                 285             


Thr Val Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val 
    290                 295                 300                 


Cys 
305 


<210> 5
<211> 1590
<212> DNA
<213> Mus sp.


<220>
<221> CDS
<222> (134)..(973)

<400> 5
gtccaactgc acctcggttc tatcgattcg aattcggcca cactggccgg atcctctaga       60

gatccctcga cctcgaccca cgcgtccgag cagcaagagg atggaaggat gaatagaagt      120

agcttcaaat agg atg gag atc tca tca ggc ttg ctg ttc ctg ggc cac         169
               Met Glu Ile Ser Ser Gly Leu Leu Phe Leu Gly His            
               1               5                   10                     

cta ata gtg ctc acc tat ggc cac ccc acc cta aaa aca cct gag agt        217
Leu Ile Val Leu Thr Tyr Gly His Pro Thr Leu Lys Thr Pro Glu Ser           
        15                  20                  25                        

gtg aca ggg acc tgg aaa gga gat gtg aag att cag tgc atc tat gat        265
Val Thr Gly Thr Trp Lys Gly Asp Val Lys Ile Gln Cys Ile Tyr Asp           
    30                  35                  40                            

ccc ctg aga ggc tac agg caa gtt ttg gtg aaa tgg ctg gta aga cac        313
Pro Leu Arg Gly Tyr Arg Gln Val Leu Val Lys Trp Leu Val Arg His           
45                  50                  55                  60            

ggc tct gac tcc gtc acc atc ttc cta cgt gac tcc act gga gac cat        361
Gly Ser Asp Ser Val Thr Ile Phe Leu Arg Asp Ser Thr Gly Asp His           
                65                  70                  75                

atc cag cag gca aag tac aga ggc cgc ctg aaa gtg agc cac aaa gtt        409
Ile Gln Gln Ala Lys Tyr Arg Gly Arg Leu Lys Val Ser His Lys Val           
            80                  85                  90                    

cca gga gat gtg tcc ctc caa ata aat acc ctg cag atg gat gac agg        457
Pro Gly Asp Val Ser Leu Gln Ile Asn Thr Leu Gln Met Asp Asp Arg           
        95                  100                 105                       

aat cac tat aca tgt gag gtc acc tgg cag act cct gat gga aac caa        505
Asn His Tyr Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln           
    110                 115                 120                           

gta ata aga gat aag atc att gag ctc cgt gtt cgg aaa tat aat cca        553
Val Ile Arg Asp Lys Ile Ile Glu Leu Arg Val Arg Lys Tyr Asn Pro           
125                 130                 135                 140           

cct aga atc aat act gaa gca cct aca acc ctg cac tcc tct ttg gaa        601
Pro Arg Ile Asn Thr Glu Ala Pro Thr Thr Leu His Ser Ser Leu Glu           
                145                 150                 155               

gca aca act ata atg agt tca acc tct gac ttg acc act aat ggg act        649
Ala Thr Thr Ile Met Ser Ser Thr Ser Asp Leu Thr Thr Asn Gly Thr           
            160                 165                 170                   

gga aaa ctt gag gag acc att gct ggt tca ggg agg aac ctg cca atc        697
Gly Lys Leu Glu Glu Thr Ile Ala Gly Ser Gly Arg Asn Leu Pro Ile           
        175                 180                 185                       

ttt gcc ata atc ttc atc atc tcc ctt tgc tgc ata gta gct gtc acc        745
Phe Ala Ile Ile Phe Ile Ile Ser Leu Cys Cys Ile Val Ala Val Thr           
    190                 195                 200                           

ata cct tat atc ttg ttc cgc tgc agg aca ttc caa caa gag tat gtc        793
Ile Pro Tyr Ile Leu Phe Arg Cys Arg Thr Phe Gln Gln Glu Tyr Val           
205                 210                 215                 220           

tat gga gtg agc agg gtg ttt gcc agg aag aca agc aac tct gaa gaa        841
Tyr Gly Val Ser Arg Val Phe Ala Arg Lys Thr Ser Asn Ser Glu Glu           
                225                 230                 235               

acc aca agg gtg act acc atc gca act gat gaa cca gat tcc cag gct        889
Thr Thr Arg Val Thr Thr Ile Ala Thr Asp Glu Pro Asp Ser Gln Ala           
            240                 245                 250                   

ctg att agt gac tac tct gat gat cct tgc ctc agc cag gag tac caa        937
Leu Ile Ser Asp Tyr Ser Asp Asp Pro Cys Leu Ser Gln Glu Tyr Gln           
        255                 260                 265                       

ata acc atc aga tca aca atg tct att cct gcc tgc tgaacacagt             983
Ile Thr Ile Arg Ser Thr Met Ser Ile Pro Ala Cys                           
    270                 275                 280                           

ttccagaaac taagaagttc ttgctactga agaaaataac atctgctaaa atgcccctac     1043

taagtcaagg tctactggcg taattacctg ttacttattt actacttgcc ttcaacatag     1103

ctttctccct ggcttccttt cttcttagac aacctaaagt atctatctag tctgccaatt     1163

ctggggccat tgagaaatcc tgggtttggc taagaatata ctacatgcac ctcaagaaat     1223

ctagcttctg ggcttcaccc agaacaattt tcttcctagg gccttcacaa ctcttctcca     1283

aacagcagag aaattccata gcagtagagg ttctttatca tgcctccaga cagcgtgagt     1343

ctcagtccta caaactcaga caagcacatg ggtctaggat tactcctctt tctctagggc     1403

cagatgactt ttaattgata ttactattgc tacattatga atctaatgca catgtattct     1463

tttgttgtta ataaatgttt aatcatgaca tcaaaaaaaa aaaaaaaaag ggcggccgcg     1523

actctagagt cgacctgcag tagggataac agggtaataa gcttggccgc catggcccaa     1583

cttgttt                                                               1590


<210> 6
<211> 280
<212> PRT
<213> Mus sp.

<400> 6
Met Glu Ile Ser Ser Gly Leu Leu Phe Leu Gly His Leu Ile Val Leu 
1               5                   10                  15      


Thr Tyr Gly His Pro Thr Leu Lys Thr Pro Glu Ser Val Thr Gly Thr 
            20                  25                  30          


Trp Lys Gly Asp Val Lys Ile Gln Cys Ile Tyr Asp Pro Leu Arg Gly 
        35                  40                  45              


Tyr Arg Gln Val Leu Val Lys Trp Leu Val Arg His Gly Ser Asp Ser 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Thr Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Arg Gly Arg Leu Lys Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Ile Asn Thr Leu Gln Met Asp Asp Arg Asn His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Ile Arg Asp 
        115                 120                 125             


Lys Ile Ile Glu Leu Arg Val Arg Lys Tyr Asn Pro Pro Arg Ile Asn 
    130                 135                 140                 


Thr Glu Ala Pro Thr Thr Leu His Ser Ser Leu Glu Ala Thr Thr Ile 
145                 150                 155                 160 


Met Ser Ser Thr Ser Asp Leu Thr Thr Asn Gly Thr Gly Lys Leu Glu 
                165                 170                 175     


Glu Thr Ile Ala Gly Ser Gly Arg Asn Leu Pro Ile Phe Ala Ile Ile 
            180                 185                 190         


Phe Ile Ile Ser Leu Cys Cys Ile Val Ala Val Thr Ile Pro Tyr Ile 
        195                 200                 205             


Leu Phe Arg Cys Arg Thr Phe Gln Gln Glu Tyr Val Tyr Gly Val Ser 
    210                 215                 220                 


Arg Val Phe Ala Arg Lys Thr Ser Asn Ser Glu Glu Thr Thr Arg Val 
225                 230                 235                 240 


Thr Thr Ile Ala Thr Asp Glu Pro Asp Ser Gln Ala Leu Ile Ser Asp 
                245                 250                 255     


Tyr Ser Asp Asp Pro Cys Leu Ser Gln Glu Tyr Gln Ile Thr Ile Arg 
            260                 265                 270         


Ser Thr Met Ser Ile Pro Ala Cys 
        275                 280 


<210> 7
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide 


<220>
<221> modified_base
<222> (16)..(18)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 7
atcctggaag tgcaannn                                                     18


<210> 8
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (16)..(18)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 8
agtgtaacag gacctnnn                                                     18


<210> 9
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 9
nnnggggatg tgaatctt                                                     18


<210> 10
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (16)..(18)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 10
aagtggctgg tacaannn                                                     18


<210> 11
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, g or t

<220>
<221> modified_base
<222> (7)..(18)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 11
nnntcannnn nnnnnnnnat cttt                                              24


<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, g or t

<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 12
nnncgtnnnt cttctggaga ccat                                              24


<210> 13
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 13
tttctacgtg actct                                                        15


<210> 14
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (1)..(27)
<223> a, c, g or t

<220>
<221> modified_base
<222> (31)..(33)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 14
nnnnnnnnnn nnnnnnnnnn nnnnnnntac nnnggccgcc tgcatgtvg                   49


<210> 15
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 15
caattgagca ccctg                                                        15


<210> 16
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (1)..(9)
<223> a, c, g or t

<220>
<221> modified_base
<222> (13)..(15)
<223> a, c, g or t

<220>
<221> modified_base
<222> (31)..(33)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 16
nnnnnnnnng acnnnagcca ctacacgtgt nnn                                    33


<210> 17
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (10)..(12)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 17
gtcacctggn nn                                                           12


<210> 18
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 18
actcctgatg gcaac                                                        15


<210> 19
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (16)..(18)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 19
actcctgatg gcaacnnn                                                     18


<210> 20
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221> modified_base
<222> (4)..(15)
<223> a, c, g or t

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 20
gtcnnnnnnn nnnnnattac tgagctccgt                                        30


<210> 21
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Unknown wild-type sequence

<400> 21
Pro Glu Ser Val Thr Gly Pro Trp Lys Gly 
1               5                   10  


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 22
Pro Tyr Ser Val Thr Gly Pro Trp Lys Gly 
1               5                   10  


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 23
Pro Trp Ser Val Thr Gly Pro Phe Lys Gly 
1               5                   10  


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 24
Pro Tyr Ser Val Thr Gly Pro Phe Lys Gly 
1               5                   10  


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic consensus
      sequence


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Trp or Phe

<400> 25
Pro Tyr Ser Val Thr Gly Pro Xaa Lys Gly 
1               5                   10  


<210> 26
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Unknown wild-type sequence

<400> 26
Gln Arg Gly Ser Asp Pro Val Thr Ile Phe Leu Arg Asp Ser 
1               5                   10                  


<210> 27
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 27
Gln Arg Asp Ser His Phe Val Thr Ile Phe Leu Arg Asp Ser 
1               5                   10                  


<210> 28
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic consensus
      sequence

<400> 28
Gln Arg Asp Ser His Phe Val Thr Ile Phe Leu Arg Asp Ser 
1               5                   10                  


<210> 29
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Unknown wild-type sequence

<400> 29
Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln Gly 
1               5                   10              


<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 30
Ser Ser Gly Asp His Ile Gln Ile Ala Lys Tyr Arg Gly 
1               5                   10              


<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 31
Ser Ser Gly Asp His Ile Gln Lys Ala Lys Tyr Gln Gly 
1               5                   10              


<210> 32
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 32
Ser Ser Gly Asp His Ile Gln Ile Ala Lys Tyr Gln Gly 
1               5                   10              


<210> 33
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic consensus
      sequence


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Arg or Gln

<400> 33
Ser Ser Gly Asp His Ile Gln Ile Ala Lys Tyr Xaa Gly 
1               5                   10              


<210> 34
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Unknown wild-type sequence

<400> 34
Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln 
1               5                   10                  15      


Thr 
    


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 35
Leu Glu Cys Asp Asp Gln Ser His Tyr Thr Cys Glu Val Thr Trp Tyr 
1               5                   10                  15      


Thr 
    


<210> 36
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 36
Leu Glu Cys Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Arg 
1               5                   10                  15      


Thr 
    


<210> 37
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 37
Leu Glu Tyr Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Lys 
1               5                   10                  15      


Thr 
    


<210> 38
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 38
Leu Glu Tyr Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Lys 
1               5                   10                  15      


Thr 
    


<210> 39
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 39
Leu Glu Tyr Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Arg 
1               5                   10                  15      


Thr 
    


<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 40
Leu Glu Tyr Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Leu 
1               5                   10                  15      


Thr 
    


<210> 41
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 41
Leu Glu Tyr Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln 
1               5                   10                  15      


Thr 
    


<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 42
Leu Glu Tyr Asp Asp Lys Ser His Tyr Thr Cys Glu Val Thr Trp Gln 
1               5                   10                  15      


Thr 
    


<210> 43
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 43
Leu Glu Trp Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Phe 
1               5                   10                  15      


Thr 
    


<210> 44
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 44
Leu Glu Trp Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Tyr 
1               5                   10                  15      


Thr 
    


<210> 45
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 45
Leu Glu Trp Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Lys 
1               5                   10                  15      


Thr 
    


<210> 46
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 46
Leu Glu Trp Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Arg 
1               5                   10                  15      


Thr 
    


<210> 47
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 47
Leu Glu Trp Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln 
1               5                   10                  15      


Thr 
    


<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 48
Leu Glu Phe Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Lys 
1               5                   10                  15      


Thr 
    


<210> 49
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 49
Leu Glu Phe Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Arg 
1               5                   10                  15      


Thr 
    


<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic consensus
      sequence


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Tyr, Trp or Phe

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Lys or Arg

<400> 50
Leu Glu Xaa Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Xaa 
1               5                   10                  15      


Thr 
    


<210> 51
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Unknown wild-type sequence

<400> 51
Asn Gln Val Val Arg Asp Lys Ile 
1               5               


<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 52
Asn Arg Val Val Arg Asp Asn Ile 
1               5               


<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 53
Asn Arg Val Val Arg Asp Asp Ile 
1               5               


<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 54
Asn Arg Val Val Arg Asp Gln Ile 
1               5               


<210> 55
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 55
Asn Arg Val Ile Arg Asp Gln Ile 
1               5               


<210> 56
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 56
Asn Arg Val Ile Arg Asp His Ile 
1               5               


<210> 57
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 57
Asn Lys Val Ile Arg Asp Gln Ile 
1               5               


<210> 58
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 58
Asn Lys Val Ile Ala Asp Asn Ile 
1               5               


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 59
Asn Lys Val Ile Ser Asp Asn Ile 
1               5               


<210> 60
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 60
Asn Gln Val Ile Arg Ser Asp Ile 
1               5               


<210> 61
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 61
Asn Lys Val Thr Arg Asp Asn Ile 
1               5               


<210> 62
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 62
Asn Lys Val Val Arg Asp Gln Ile 
1               5               


<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 63
Asn Lys Val Val Arg Asp Asn Ile 
1               5               


<210> 64
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 64
Asn Lys Val Val Arg Asp Asp Ile 
1               5               


<210> 65
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 65
Asn Lys Val Val Arg Ser Asp Ile 
1               5               


<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 66
Asn Lys Val Val Ser Asp Asp Ile 
1               5               


<210> 67
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic consensus
      sequence


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Lys or Arg

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Val or Ile

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Gln, Asp or Asn

<400> 67
Asn Xaa Val Xaa Arg Asp Xaa Ile 
1               5               


