                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
       Vratsanos, George
 
<120>  METHOD OF PREVENTING THE DEVELOPMENT OF RHEUMATOID ARTHRITIS IN 
       SUBJECTS WITH UNDIFFERENTIATED ARTHRITIS

<130>  11268 NP

<150>  61/050,336
<151>  2008-05-05

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1223
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (11)..(1159)

<400>  1
agcttcacca atg ggt gta ctg ctc aca cag agg acg ctg ctc agt ctg          49
           Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu            
           1               5                   10                         

gtc ctt gca ctc ctg ttt cca agc atg gcg agc atg gca atg cac gtg         97
Val Leu Ala Leu Leu Phe Pro Ser Met Ala Ser Met Ala Met His Val           
    15                  20                  25                            

gcc cag cct gct gtg gta ctg gcc agc agc cga ggc atc gcc agc ttt        145
Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe           
30                  35                  40                  45            

gtg tgt gag tat gca tct cca ggc aaa gcc act gag gtc cgg gtg aca        193
Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr           
                50                  55                  60                

gtg ctt cgg cag gct gac agc cag gtg act gaa gtc tgt gcg gca acc        241
Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr           
            65                  70                  75                    

tac atg atg ggg aat gag ttg acc ttc cta gat gat tcc atc tgc acg        289
Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr           
        80                  85                  90                        

ggc acc tcc agt gga aat caa gtg aac ctc act atc caa gga ctg agg        337
Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg           
    95                  100                 105                           

gcc atg gac acg gga ctc tac atc tgc aag gtg gag ctc atg tac cca        385
Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro           
110                 115                 120                 125           

ccg cca tac tac ctg ggc ata ggc aac gga acc cag att tat gta att        433
Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile           
                130                 135                 140               

gat cca gaa ccg tgc cca gat tct gat cag gag ccc aaa tct tct gac        481
Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Glu Pro Lys Ser Ser Asp           
            145                 150                 155                   

aaa act cac aca tcc cca ccg tcc cca gca cct gaa ctc ctg ggg gga        529
Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly           
        160                 165                 170                       

tcg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc        577
Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
    175                 180                 185                           

tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa        625
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu           
190                 195                 200                 205           

gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat        673
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
                210                 215                 220               

aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt        721
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg           
            225                 230                 235                   

gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag        769
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys           
        240                 245                 250                       

gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag        817
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu           
    255                 260                 265                           

aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac        865
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
270                 275                 280                 285           

acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg        913
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu           
                290                 295                 300               

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg        961
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
            305                 310                 315                   

gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg       1009
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
        320                 325                 330                       

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac       1057
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
    335                 340                 345                           

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat       1105
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
350                 355                 360                 365           

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg       1153
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
                370                 375                 380               

ggt aaa tgagtgcgac ggccggcaag ccccgctccc cgggctctcg cggtcgcacg        1209
Gly Lys                                                                   
                                                                          

aggatgcttc taga                                                       1223


<210>  2
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Met His Val Ala Gln Pro 
            20                  25                  30          


Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu 
        35                  40                  45              


Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg 
    50                  55                  60                  


Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met 
65                  70                  75                  80  


Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser 
                85                  90                  95      


Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp 
            100                 105                 110         


Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr 
        115                 120                 125             


Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu 
    130                 135                 140                 


Pro Cys Pro Asp Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His 
145                 150                 155                 160 


Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
                165                 170                 175     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            180                 185                 190         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        195                 200                 205             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    210                 215                 220                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
225                 230                 235                 240 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                245                 250                 255     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            260                 265                 270         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        275                 280                 285             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    290                 295                 300                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
305                 310                 315                 320 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                325                 330                 335     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            340                 345                 350         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        355                 360                 365             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380             





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