                         SEQUENCE LISTING

<110>  University of Washington
       Felise, Heather
       Miller, Samuel
       Kline, Toni
 
<120>  5-Substituted-2-Imino-Thiazolidinone Compounds and Their Use as 
       Inhibitors of Bacterial Infection

<130>  UWOTL-1-32498

<150>  US 61/028,777
<151>  2008-02-14

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  685
<212>  PRT
<213>  Salmonella typhimurium

<400>  1

Met Val Thr Ser Val Arg Thr Gln Pro Pro Val Ile Met Pro Gly Met 
1               5                   10                  15      


Gln Thr Glu Ile Lys Thr Gln Ala Thr Asn Leu Ala Ala Asn Leu Ser 
            20                  25                  30          


Ala Val Arg Glu Ser Ala Thr Ala Thr Leu Ser Gly Glu Ile Lys Gly 
        35                  40                  45              


Pro Gln Leu Glu Asp Phe Pro Ala Leu Ile Lys Gln Ala Ser Leu Asp 
    50                  55                  60                  


Ala Leu Phe Lys Cys Gly Lys Asp Ala Glu Ala Leu Lys Glu Val Phe 
65                  70                  75                  80  


Thr Asn Ser Asn Asn Val Ala Gly Lys Lys Ala Ile Met Glu Phe Ala 
                85                  90                  95      


Gly Leu Phe Arg Ser Ala Leu Asn Ala Thr Ser Asp Ser Pro Glu Ala 
            100                 105                 110         


Lys Thr Leu Leu Met Lys Val Gly Ala Glu Tyr Thr Ala Gln Ile Ile 
        115                 120                 125             


Lys Asp Gly Leu Lys Glu Lys Ser Ala Phe Gly Pro Trp Leu Pro Glu 
    130                 135                 140                 


Thr Lys Lys Ala Glu Ala Lys Leu Glu Asn Leu Glu Lys Gln Leu Leu 
145                 150                 155                 160 


Asp Ile Ile Lys Asn Asn Thr Gly Gly Glu Leu Ser Lys Leu Ser Thr 
                165                 170                 175     


Asn Leu Val Met Gln Glu Val Met Pro Tyr Ile Ala Ser Cys Ile Glu 
            180                 185                 190         


His Asn Phe Gly Cys Thr Leu Asp Pro Leu Thr Arg Ser Asn Leu Thr 
        195                 200                 205             


His Leu Val Asp Lys Ala Ala Ala Lys Ala Val Glu Ala Leu Asp Met 
    210                 215                 220                 


Cys His Gln Lys Leu Thr Gln Glu Gln Gly Thr Ser Val Gly Arg Glu 
225                 230                 235                 240 


Ala Arg His Leu Glu Met Gln Thr Leu Ile Pro Leu Leu Leu Arg Asn 
                245                 250                 255     


Val Phe Ala Gln Ile Pro Ala Asp Lys Leu Pro Asp Pro Lys Ile Pro 
            260                 265                 270         


Glu Pro Ala Ala Gly Pro Val Pro Asp Gly Gly Lys Lys Ala Glu Pro 
        275                 280                 285             


Thr Gly Ile Asn Ile Asn Ile Asn Ile Asp Ser Ser Asn His Ser Val 
    290                 295                 300                 


Asp Asn Ser Lys His Ile Asn Asn Ser Arg Ser His Val Asp Asn Ser 
305                 310                 315                 320 


Gln Arg His Ile Asp Asn Ser Asn His Asp Asn Ser Arg Lys Thr Ile 
                325                 330                 335     


Asp Asn Ser Arg Thr Phe Ile Asp Asn Ser Gln Arg Asn Gly Glu Ser 
            340                 345                 350         


His His Ser Thr Asn Ser Ser Asn Val Ser His Ser His Ser Arg Val 
        355                 360                 365             


Asp Ser Thr Thr His Gln Thr Glu Thr Ala His Ser Ala Ser Thr Gly 
    370                 375                 380                 


Ala Ile Asp His Gly Ile Ala Gly Lys Ile Asp Val Thr Ala His Ala 
385                 390                 395                 400 


Thr Ala Glu Ala Val Thr Asn Ala Ser Ser Glu Ser Lys Asp Gly Lys 
                405                 410                 415     


Val Val Thr Ser Glu Lys Gly Thr Thr Gly Glu Thr Thr Ser Phe Asp 
            420                 425                 430         


Glu Val Asp Gly Val Thr Ser Lys Ser Ile Ile Gly Lys Pro Val Gln 
        435                 440                 445             


Ala Thr Val His Gly Val Asp Asp Asn Lys Gln Gln Ser Gln Thr Ala 
    450                 455                 460                 


Glu Ile Val Asn Val Lys Pro Leu Ala Ser Gln Leu Ala Gly Val Glu 
465                 470                 475                 480 


Asn Val Lys Thr Asp Thr Leu Gln Ser Asp Thr Thr Val Ile Thr Gly 
                485                 490                 495     


Asn Lys Ala Gly Thr Thr Asp Asn Asp Asn Ser Gln Thr Asp Lys Thr 
            500                 505                 510         


Gly Pro Phe Ser Gly Leu Lys Phe Lys Gln Asn Ser Phe Leu Ser Thr 
        515                 520                 525             


Val Pro Ser Val Thr Asn Met His Ser Met His Phe Asp Ala Arg Glu 
    530                 535                 540                 


Thr Phe Leu Gly Val Ile Arg Lys Ala Leu Glu Pro Asp Thr Ser Thr 
545                 550                 555                 560 


Pro Phe Pro Val Arg Arg Ala Phe Asp Gly Leu Arg Ala Glu Ile Leu 
                565                 570                 575     


Pro Asn Asp Thr Ile Lys Ser Ala Ala Leu Lys Ala Gln Cys Ser Asp 
            580                 585                 590         


Ile Asp Lys His Pro Glu Leu Lys Ala Lys Met Glu Thr Leu Lys Glu 
        595                 600                 605             


Val Ile Thr His His Pro Gln Lys Glu Lys Leu Ala Glu Ile Ala Leu 
    610                 615                 620                 


Gln Phe Ala Arg Glu Ala Gly Leu Thr Arg Leu Lys Gly Glu Thr Asp 
625                 630                 635                 640 


Tyr Val Leu Ser Asn Val Leu Asp Gly Leu Ile Gly Asp Gly Ser Trp 
                645                 650                 655     


Arg Ala Gly Pro Ala Tyr Glu Ser Tyr Leu Asn Lys Pro Gly Val Asp 
            660                 665                 670         


Arg Val Ile Thr Thr Val Asp Gly Leu His Met Gln Arg 
        675                 680                 685 


<210>  2
<211>  2055
<212>  DNA
<213>  Salmonella typhimurium

<400>  2
atggttacaa gtgtaaggac tcagcccccc gtcataatgc caggtatgca gaccgagatc     60

aaaacgcagg ccacgaatct tgcggcgaat ctttccgcag tcagagaaag tgccacagcg    120

acgctgtcag gggaaattaa aggcccgcaa ctggaagatt ttcccgcgct gatcaaacag    180

gcgagtctgg atgcattgtt taaatgcggg aaagacgctg aggcgttaaa agaagttttt    240

accaattcaa ataatgtcgc cggtaagaaa gcgataatgg agtttgccgg gctctttcgt    300

tcagcgctca acgccaccag tgattctcct gaggcgaaga cgctactgat gaaggtgggg    360

gcagagtata ccgcgcaaat cataaaagat ggcctgaaag aaaagtcagc ttttgggcca    420

tggctgccag aaacaaagaa agcggaagcg aagctggaaa acctggaaaa gcagctgtta    480

gatattatca aaaataacac tggcggtgaa ttaagtaaat tatcgacgaa tcttgttatg    540

caggaggtga tgccctatat tgccagctgc attgaacata actttggctg tacgttagat    600

ccgttaaccc gcagcaatct tacgcacctt gttgacaaag cggcggcgaa ggctgttgag    660

gcgcttgata tgtgccacca aaaattaacg caagagcagg gtaccagcgt aggacgggaa    720

gcccggcacc ttgaaatgca aacgttgata cccctgctgc tacgtaatgt ttttgcacaa    780

attcctgcag ataaactgcc tgaccctaaa attccggagc ctgcggctgg accagtacct    840

gatggtggga aaaaagcaga acctacgggt attaatatca atattaatat tgatagcagt    900

aaccatagcg tggataacag taagcatatt aacaatagcc gaagccatgt cgataatagc    960

cagcgccata tcgataatag caaccatgat aatagccgga agacgattga taatagccga   1020

acatttattg ataacagcca acgcaatggc gagtcacacc attcgactaa cagcagcaac   1080

gtaagtcata gtcattcgcg tgtggattcg actacgcatc aaacggagac ggcacacagc   1140

gccagcacag gggcaattga ccatggcatc gcgggtaaaa ttgacgtcac ggctcatgcg   1200

acggcagagg ctgtgaccaa cgcttcatcc gaaagtaaag atggaaaggt ggtcacgtca   1260

gaaaagggca ctacgggtga aacaacctct tttgatgaag tcgatggcgt aaccagcaag   1320

agcattatcg gcaagccggt acaggccacg gtgcacggcg ttgatgataa taaacagcaa   1380

agccagacgg cagagattgt gaatgtgaag ccgcttgcca gtcaactggc tggcgtcgag   1440

aatgttaaaa ccgatacctt acaatcagac acgacggtaa ttacaggtaa taaagccggt   1500

acgaccgata atgataatag tcagacagat aagactggcc cattttctgg tttgaagttt   1560

aagcaaaata gtttcctctc aacagtaccg agcgttacga atatgcattc aatgcatttc   1620

gacgcccgtg agacgttttt gggtgtgata cgtaaagccc tggagccaga tacctccaca   1680

ccgttccctg tacgcagagc gtttgacggc ttgcgtgcgg aaatattacc caatgacacg   1740

ataaagagtg cagcgttgaa agcgcaatgt agcgatattg acaagcaccc agaattgaaa   1800

gcgaaaatgg agactctcaa agaggtcatt actcatcatc cacaaaaaga aaaactggct   1860

gagattgcac tgcagtttgc cagagaggcg gggctgacca ggctaaaagg ggaaactgac   1920

tatgtgttaa gtaatgtgct ggacggcctt atcggagacg gtagctggcg agctggcccg   1980

gcttacgagt catacctgaa taaacctggc gtggatcggg ttattactac cgttgatggc   2040

ttgcacatgc agcgt                                                    2055


<210>  3
<211>  265
<212>  PRT
<213>  Yersinia enterocolitica

<400>  3

Met Leu Ala Ser Leu Gly Ile Ser Arg Gly Glu Arg Val Leu Ala Ala 
1               5                   10                  15      


Ser Asp Asn Val Pro Ile Ser Ser Gly Gln Gly Ser Gln Gln Ala Asp 
            20                  25                  30          


Tyr Ser Leu Ala Leu Leu Ala Lys Asp Val Tyr Ala Pro Ala Ala Arg 
        35                  40                  45              


Ser Ile Gly Gly Phe Thr Arg Leu Gly Asp Ala Ala Leu Leu Ser Ala 
    50                  55                  60                  


Gly Ile Asp Pro Ala Ser Leu Ser Asp Thr Ala Ser Gly Phe Gln Ala 
65                  70                  75                  80  


Gly Ile Tyr Ser Asp Asn Gln Gln Tyr Val Leu Ser Phe Ala Gly Thr 
                85                  90                  95      


Asn Asp Ile Gln Asp Trp Leu Ser Asn Ile Arg Gln Ala Thr Gly Tyr 
            100                 105                 110         


Glu Asp Val Gln Tyr Asn Gln Ala Val Ala Leu Gly Lys Thr Ala Lys 
        115                 120                 125             


Met Ala Phe Gly Asp Ala Leu Val Ile Thr Gly His Ser Leu Gly Gly 
    130                 135                 140                 


Gly Leu Ala Ala Thr Ala Ala Leu Ala Ser Gly Thr Phe Ala Val Thr 
145                 150                 155                 160 


Phe Asn Ala Ala Gly Val Ser Asp His Thr Leu Asn Arg Leu Gly Met 
                165                 170                 175     


Asn Pro Ala Gln Ala Arg Gln Ser Ala Glu Gly Gly Gly Ile Arg Arg 
            180                 185                 190         


Tyr Ser Glu Gln His Asp Leu Leu Thr Asp Thr Gln Glu Ser Thr Ser 
        195                 200                 205             


Leu Ile Pro Asp Ala Ile Gly His Lys Ile Thr Leu Ala Asn Ser Asp 
    210                 215                 220                 


Lys Leu Ala Gly Val Asn Asp Trp Leu Pro His Lys His Leu Glu Arg 
225                 230                 235                 240 


Ser Leu Ala Ala His Gly Ile Asp Lys Val Leu Ser Ser Met Asn Glu 
                245                 250                 255     


Gln Gln Pro Trp Glu Arg Gln Tyr Ala 
            260                 265 


<210>  4
<211>  798
<212>  DNA
<213>  Yersinia enterocolitica

<400>  4
atgctggcta gccttggaat atcacgtggt gaacgtgttt tagctgccag cgacaatgta     60

ccgatatcaa gtggacaagg atcacagcaa gcggactatt cattagcatt actcgcgaaa    120

gatgtttacg ctcctgctgc gagaagcatc ggcggattta cacggttggg tgatgccgcg    180

ttgctttcgg cggggataga tccggcgagc ctatctgata cagcttcagg gtttcaggct    240

gggatttaca gtgataatca acagtatgtc ctctctttcg cgggtaccaa tgatattcag    300

gattggttaa gtaatatccg gcaagcaaca ggttatgagg atgttcaata taatcaggct    360

gttgcgctgg ggaaaaccgc taaaatggca tttggtgatg cactggtcat taccggccat    420

tcattaggcg gtgggctggc agccacggct gcattagcca gcgggacttt tgctgtaaca    480

tttaatgccg ccggtgtttc tgatcacaca ttaaatcgtt tgggcatgaa ccctgctcag    540

gcgcggcagt cggcsgaggg gggtggcata cgacgttata gtgagcaaca tgacttattg    600

acggatactc aagagtcaac ctcactcatt cctgatgcaa ttggccataa gatcacattg    660

gctaatagcg ataaactggc gggggtaaat gactggctgc cacacaaaca cctcgaacgt    720

agccttgcgg cgcatggtat tgataaagtg ctcagttcca tgaatgaaca acaaccttgg    780

gagcggcagt atgcctga                                                  798

