                         SEQUENCE LISTING

<110>  Abbott GmbH & Co. KG
       Abbott Laboratories
 
<120>  Antibodies to Receptor of Advanced Glycation End Products (RAGE) 
       and Uses thereof

<130>  M/49231-PCT

<160>  94    

<170>  PatentIn version 3.3

<210>  1
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  VH 7F9

<400>  1

Glu Glu Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Leu Gly Gly 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Val Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Tyr Tyr Ser Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Gly Ser 
65                  70                  75                  80  


Val Ser Leu Gln Met Asp Asn Leu Thr Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asn Ala Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  VH 7F9 CDR-H1

<400>  2

Asn Tyr Trp Met Asp 
1               5   


<210>  3
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  VH 7F9 CDR-H2

<400>  3

Glu Ile Arg Leu Lys Ser Asn Tyr Tyr Ser Thr His Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  4
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  VH 7F9 CDR-H3

<400>  4

Asn Ala Tyr Trp Tyr Phe Asp Val 
1               5               


<210>  5
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL 7F9

<400>  5

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ala Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Leu Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  6
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  VL 7F9  CDR-L1

<400>  6

Lys Ala Ser Gln Asp Val Gly Thr Ser Val Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  VL 7F9  CDR-L2

<400>  7

Trp Thr Ser Thr Arg His Thr 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  VL 7F9  CDR-L3

<400>  8

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  9
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  VH 11E6

<400>  9

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Asn Thr Gly Glu Ser Ile Tyr Ser Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Arg Met Val Thr Ala Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  VH 11E6 CDR-H1

<400>  10

Asn Phe Gly Met Asn 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  VH 11E6 CDR-H2

<400>  11

Tyr Ile Asn Thr Asn Thr Gly Glu Ser Ile Tyr Ser Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  VH 11E6 CDR-H3

<400>  12

Ser Arg Met Val Thr Ala Tyr Gly Met Asp Tyr 
1               5                   10      


<210>  13
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VL 11E6

<400>  13

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Leu Ser Asn Met Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Val Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  14
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VL 11E6 CDR-L1

<400>  14

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VL 11E6 CDR-L2

<400>  15

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VL 11E6 CDR-L3

<400>  16

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  17
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VH 4E5

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Asn Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ala Gly Thr Ala Arg Ala Arg Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  18
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VH 4E5 CDR-H1

<400>  18

Asn Tyr Leu Ile Glu 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VH 4E5 CDR-H2

<400>  19

Val Ile Asn Pro Gly Ser Gly Gly Thr Asn His Asn Glu Lys Phe Lys 
1               5                   10                  15      


Val 
    


<210>  20
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VH 4E5 CDR-H3

<400>  20

Ser Ala Gly Thr Ala Arg Ala Arg Phe Ala Tyr 
1               5                   10      


<210>  21
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VL 4E5

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  22
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VL 4E5 CDR-L1

<400>  22

Arg Ala Ser Gln Asp Ile Gly Ser Ser Leu Asn 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VL 4E5 CDR-L2

<400>  23

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  mAb VL 4E5 CDR-L3

<400>  24

Leu Gln Tyr Ala Ser Phe Pro Phe Thr 
1               5                   


<210>  25
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  26
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  26

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  27
<211>  6276
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding OmpA-[RAGE (23-340)]-6His

<400>  27
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat    600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa    660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc    720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga    780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc    840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac    900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac    960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat   1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag   1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca   1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac   1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg   1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca   1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac   1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa   1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga   1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg   1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc   1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag   1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc   1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg   1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac   1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga   1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt   1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag   2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg   2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta   2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc   2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg   2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta   2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg   2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct   2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag   2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc   2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag   2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt   2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa   2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg   2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg   2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc   2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta   3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca   3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc   3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc   3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa   3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc   3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac   3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca   3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta   3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa   3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca   3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa   3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt   3780

atcccactac cgagatgtcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg   3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca   3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta   3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg   4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat   4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct   4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg   4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat   4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc   4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca   4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg   4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt   4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg   4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct   4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga   4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg   4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc   4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg   4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg   4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatcga tctcgatccc   4980

gcgaaattaa tacgactcac tataggggaa ttgtgagcgg ataacaattc ccctctagaa   5040

ataattttgt ttaactttaa gaaggagata tacatatgaa aaagacagct atcgcgattg   5100

cagtggcact ggctggtttc gctaccgtag cgcaggccgc tcaaaacatc acagcccgga   5160

ttggcgagcc actggtgctg aagtgtaagg gggcccccaa gaaaccaccc cagcggctgg   5220

aatggaaact gaacacaggc cggacagaag cttggaaggt cctgtctccc cagggaggag   5280

gcccctggga cagtgtggct cgtgtccttc ccaacggctc cctcttcctt ccggctgtcg   5340

ggatccagga tgaggggatt ttccggtgcc aggcaatgaa caggaatgga aaggagacca   5400

agtccaacta ccgagtccgt gtctaccaga ttcctgggaa gccagaaatt gtagattctg   5460

cctctgaact cacggctggt gttcccaata aggtggggac atgtgtgtca gagggaagct   5520

accctgcagg gactcttagc tggcacttgg atgggaagcc cctggtgcct aatgagaagg   5580

gagtatctgt gaaggaacag accaggagac accctgagac agggctcttc acactgcagt   5640

cggagctaat ggtgacccca gcccggggag gagatccccg tcccaccttc tcctgtagct   5700

tcagcccagg ccttccccga caccgggcct tgcgcacagc ccccatccag ccccgtgtct   5760

gggagcctgt gcctctggag gaggtccaat tggtggtgga gccagaaggt ggagcagtag   5820

ctcctggtgg aaccgtaacc ctgacctgtg aagtccctgc ccagccctct cctcaaatcc   5880

actggatgaa ggatggtgtg cccttgcccc ttccccccag ccctgtgctg atcctccctg   5940

agatagggcc tcaggaccag ggaacctaca gctgtgtggc cacccattcc agccacgggc   6000

cccaggaaag ccgtgctgtc agcatcagca tcatcgaacc aggcgaggag gggccaactg   6060

caggctctgt gggaggatca gggctgggaa ctcaccacca ccaccaccac tgactcgagc   6120

accaccacca ccaccactga gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg   6180

ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa cgggtcttga   6240

ggggtttttt gctgaaagga ggaactatat ccggat                             6276


<210>  28
<211>  5617
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding 6His-(Thr)-[RAGE (24-129)]

<400>  28
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat    600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa    660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc    720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga    780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc    840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac    900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac    960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat   1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag   1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca   1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac   1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg   1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca   1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac   1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa   1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga   1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg   1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc   1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag   1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc   1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg   1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac   1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga   1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt   1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag   2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg   2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta   2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc   2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg   2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta   2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg   2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct   2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag   2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc   2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag   2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt   2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa   2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg   2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg   2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc   2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta   3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca   3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc   3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc   3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa   3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc   3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac   3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca   3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta   3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa   3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca   3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa   3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt   3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg   3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca   3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta   3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg   4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat   4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct   4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg   4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat   4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc   4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca   4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg   4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt   4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg   4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct   4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga   4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg   4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc   4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg   4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg   4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga   4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa   5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac   5100

agcagcggcc tggtgccgcg cggcagccat atgcaaaaca tcacagcccg gattggcgag   5160

ccactggtgc tgaagtgtaa gggggccccc aagaaaccac cccagcggct ggaatggaaa   5220

ctgaacacag gccggacaga agcttggaag gtcctgtctc cccagggagg aggcccctgg   5280

gacagtgtgg ctcgtgtcct tcccaacggc tccctcttcc ttccggctgt cgggatccag   5340

gatgagggga ttttccggtg ccaggcaatg aacaggaatg gaaaggagac caagtccaac   5400

taccgagtcc gtgtctacca gattcctggg aagccagaaa ttgtagattc ttgactcgag   5460

caccaccacc accaccactg agatccggct gctaacaaag cccgaaagga agctgagttg   5520

gctgctgcca ccgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg   5580

aggggttttt tgctgaaagg aggaactata tccggat                            5617


<210>  29
<211>  5932
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding 6His-(Thr)-[RAGE (24-234)]

<400>  29
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat    600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa    660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc    720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga    780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc    840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac    900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac    960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat   1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag   1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca   1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac   1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg   1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca   1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac   1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa   1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga   1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg   1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc   1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag   1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc   1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg   1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac   1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga   1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt   1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag   2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg   2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta   2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc   2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg   2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta   2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg   2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct   2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag   2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc   2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag   2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt   2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa   2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg   2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg   2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc   2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta   3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca   3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc   3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc   3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa   3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc   3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac   3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca   3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta   3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa   3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca   3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa   3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt   3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg   3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca   3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta   3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg   4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat   4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct   4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg   4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat   4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc   4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca   4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg   4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt   4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg   4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct   4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga   4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg   4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc   4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg   4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg   4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga   4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa   5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac   5100

agcagcggcc tggtgccgcg cggcagccat atgcaaaaca tcacagcccg gattggcgag   5160

ccactggtgc tgaagtgtaa gggggccccc aagaaaccac cccagcggct ggaatggaaa   5220

ctgaacacag gccggacaga agcttggaag gtcctgtctc cccagggagg aggcccctgg   5280

gacagtgtgg ctcgtgtcct tcccaacggc tccctcttcc ttccggctgt cgggatccag   5340

gatgagggga ttttccggtg ccaggcaatg aacaggaatg gaaaggagac caagtccaac   5400

taccgagtcc gtgtctacca gattcctggg aagccagaaa ttgtagattc tgcctctgaa   5460

ctcacggctg gtgttcccaa taaggtgggg acatgtgtgt cagagggaag ctaccctgca   5520

gggactctta gctggcactt ggatgggaag cccctggtgc ctaatgagaa gggagtatct   5580

gtgaaggaac agaccaggag acaccctgag acagggctct tcacactgca gtcggagcta   5640

atggtgaccc cagcccgggg aggagatccc cgtcccacct tctcctgtag cttcagccca   5700

ggccttcccc gacaccgggc cttgcgcaca gcccccatcc agccccgtgt ctgggagcct   5760

gtgccttgac tcgagcacca ccaccaccac cactgagatc cggctgctaa caaagcccga   5820

aaggaagctg agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc   5880

tctaaacggg tcttgagggg ttttttgctg aaaggaggaa ctatatccgg at           5932


<210>  30
<211>  6238
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding 6His-(Thr)-[RAGE (24-336)]

<400>  30
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat    600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa    660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc    720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga    780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc    840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac    900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac    960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat   1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag   1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca   1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac   1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg   1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca   1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac   1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa   1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga   1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg   1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc   1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag   1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc   1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg   1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac   1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga   1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt   1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag   2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg   2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta   2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc   2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg   2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta   2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg   2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct   2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag   2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc   2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag   2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt   2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa   2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg   2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg   2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc   2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta   3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca   3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc   3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc   3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa   3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc   3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac   3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca   3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta   3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa   3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca   3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa   3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt   3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg   3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca   3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta   3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg   4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat   4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct   4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg   4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat   4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc   4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca   4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg   4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt   4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg   4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct   4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga   4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg   4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc   4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg   4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg   4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga   4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa   5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac   5100

agcagcggcc tggtgccgcg cggcagccat atgcaaaaca tcacagcccg gattggcgag   5160

ccactggtgc tgaagtgtaa gggggccccc aagaaaccac cccagcggct ggaatggaaa   5220

ctgaacacag gccggacaga agcttggaag gtcctgtctc cccagggagg aggcccctgg   5280

gacagtgtgg ctcgtgtcct tcccaacggc tccctcttcc ttccggctgt cgggatccag   5340

gatgagggga ttttccggtg ccaggcaatg aacaggaatg gaaaggagac caagtccaac   5400

taccgagtcc gtgtctacca gattcctggg aagccagaaa ttgtagattc tgcctctgaa   5460

ctcacggctg gtgttcccaa taaggtgggg acatgtgtgt cagagggaag ctaccctgca   5520

gggactctta gctggcactt ggatgggaag cccctggtgc ctaatgagaa gggagtatct   5580

gtgaaggaac agaccaggag acaccctgag acagggctct tcacactgca gtcggagcta   5640

atggtgaccc cagcccgggg aggagatccc cgtcccacct tctcctgtag cttcagccca   5700

ggccttcccc gacaccgggc cttgcgcaca gcccccatcc agccccgtgt ctgggagcct   5760

gtgcctctgg aggaggtcca attggtggtg gagccagaag gtggagcagt agctcctggt   5820

ggaaccgtaa ccctgacctg tgaagtccct gcccagccct ctcctcaaat ccactggatg   5880

aaggatggtg tgcccttgcc ccttcccccc agccctgtgc tgatcctccc tgagataggg   5940

cctcaggacc agggaaccta cagctgtgtg gccacccatt ccagccacgg gccccaggaa   6000

agccgtgctg tcagcatcag catcatcgaa ccaggcgagg aggggccaac tgcaggctct   6060

gtgggaggat catgactcga gcaccaccac caccaccact gagatccggc tgctaacaaa   6120

gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactagc ataacccctt   6180

ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat atccggat     6238


<210>  31
<211>  5614
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding 6His-(Thr)-[RAGE (130-234)]

<400>  31
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat    600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa    660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc    720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga    780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc    840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac    900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac    960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat   1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag   1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca   1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac   1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg   1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca   1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac   1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa   1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga   1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg   1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc   1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag   1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc   1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg   1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac   1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga   1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt   1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag   2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg   2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta   2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc   2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg   2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta   2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg   2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct   2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag   2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc   2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag   2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt   2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa   2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg   2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg   2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc   2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta   3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca   3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc   3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc   3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa   3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc   3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac   3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca   3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta   3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa   3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca   3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa   3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt   3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg   3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca   3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta   3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg   4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat   4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct   4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg   4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat   4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc   4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca   4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg   4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt   4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg   4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct   4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga   4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg   4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc   4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg   4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg   4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga   4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa   5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac   5100

agcagcggcc tggtgccgcg cggcagccat atggcctctg aactcacggc tggtgttccc   5160

aataaggtgg ggacatgtgt gtcagaggga agctaccctg cagggactct tagctggcac   5220

ttggatggga agcccctggt gcctaatgag aagggagtat ctgtgaagga acagaccagg   5280

agacaccctg agacagggct cttcacactg cagtcggagc taatggtgac cccagcccgg   5340

ggaggagatc cccgtcccac cttctcctgt agcttcagcc caggccttcc ccgacaccgg   5400

gccttgcgca cagcccccat ccagccccgt gtctgggagc ctgtgccttg actcgagcac   5460

caccaccacc accactgaga tccggctgct aacaaagccc gaaaggaagc tgagttggct   5520

gctgccaccg ctgagcaata actagcataa ccccttgggg cctctaaacg ggtcttgagg   5580

ggttttttgc tgaaaggagg aactatatcc ggat                               5614


<210>  32
<211>  5920
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding 6His-(Thr)-[RAGE (130-336)]

<400>  32
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat    600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa    660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc    720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga    780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc    840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac    900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac    960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat   1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag   1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca   1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac   1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg   1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca   1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac   1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa   1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga   1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg   1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc   1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag   1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc   1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg   1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac   1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga   1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt   1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag   2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg   2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta   2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc   2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg   2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta   2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg   2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct   2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag   2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc   2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag   2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt   2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa   2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg   2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg   2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc   2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta   3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca   3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc   3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc   3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa   3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc   3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac   3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca   3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta   3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa   3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca   3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa   3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt   3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg   3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca   3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta   3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg   4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat   4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct   4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg   4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat   4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc   4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca   4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg   4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt   4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg   4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct   4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga   4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg   4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc   4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg   4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg   4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga   4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa   5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac   5100

agcagcggcc tggtgccgcg cggcagccat atggcctctg aactcacggc tggtgttccc   5160

aataaggtgg ggacatgtgt gtcagaggga agctaccctg cagggactct tagctggcac   5220

ttggatggga agcccctggt gcctaatgag aagggagtat ctgtgaagga acagaccagg   5280

agacaccctg agacagggct cttcacactg cagtcggagc taatggtgac cccagcccgg   5340

ggaggagatc cccgtcccac cttctcctgt agcttcagcc caggccttcc ccgacaccgg   5400

gccttgcgca cagcccccat ccagccccgt gtctgggagc ctgtgcctct ggaggaggtc   5460

caattggtgg tggagccaga aggtggagca gtagctcctg gtggaaccgt aaccctgacc   5520

tgtgaagtcc ctgcccagcc ctctcctcaa atccactgga tgaaggatgg tgtgcccttg   5580

ccccttcccc ccagccctgt gctgatcctc cctgagatag ggcctcagga ccagggaacc   5640

tacagctgtg tggccaccca ttccagccac gggccccagg aaagccgtgc tgtcagcatc   5700

agcatcatcg aaccaggcga ggaggggcca actgcaggct ctgtgggagg atcatgactc   5760

gagcaccacc accaccacca ctgagatccg gctgctaaca aagcccgaaa ggaagctgag   5820

ttggctgctg ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc   5880

ttgaggggtt ttttgctgaa aggaggaact atatccggat                         5920


<210>  33
<211>  5605
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding 6His-(Thr)-[RAGE (235-336)]

<400>  33
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc    120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg    180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc    240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt    300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc    360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta    420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt    480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta    540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat    600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa    660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc    720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga    780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc    840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac    900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac    960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat   1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag   1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca   1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac   1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg   1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca   1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac   1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa   1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga   1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg   1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc   1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag   1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc   1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg   1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac   1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga   1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt   1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag   2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg   2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta   2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc   2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg   2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta   2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg   2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct   2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag   2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc   2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag   2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt   2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa   2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg   2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg   2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc   2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta   3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca   3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc   3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc   3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa   3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc   3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac   3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca   3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta   3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa   3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat   3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca   3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa   3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt   3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg   3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca   3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta   3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg   4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat   4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct   4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg   4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat   4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc   4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca   4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg   4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt   4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg   4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct   4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga   4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg   4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc   4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg   4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg   4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga   4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa   5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac   5100

agcagcggcc tggtgccgcg cggcagccat atgctggagg aggtccaatt ggtggtggag   5160

ccagaaggtg gagcagtagc tcctggtgga accgtaaccc tgacctgtga agtccctgcc   5220

cagccctctc ctcaaatcca ctggatgaag gatggtgtgc ccttgcccct tccccccagc   5280

cctgtgctga tcctccctga gatagggcct caggaccagg gaacctacag ctgtgtggcc   5340

acccattcca gccacgggcc ccaggaaagc cgtgctgtca gcatcagcat catcgaacca   5400

ggcgaggagg ggccaactgc aggctctgtg ggaggatcat gactcgagca ccaccaccac   5460

caccactgag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc   5520

gctgagcaat aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg   5580

ctgaaaggag gaactatatc cggat                                         5605


<210>  34
<211>  345
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE Protein #1

<400>  34

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro 
            20                  25                  30          


Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu 
        35                  40                  45              


Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser 
    50                  55                  60                  


Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn 
65                  70                  75                  80  


Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe 
                85                  90                  95      


Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr 
            100                 105                 110         


Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser 
        115                 120                 125             


Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val 
    130                 135                 140                 


Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly 
145                 150                 155                 160 


Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr 
                165                 170                 175     


Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met 
            180                 185                 190         


Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser 
        195                 200                 205             


Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile 
    210                 215                 220                 


Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val 
225                 230                 235                 240 


Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr Leu 
                245                 250                 255     


Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met Lys 
            260                 265                 270         


Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu Pro 
        275                 280                 285             


Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His 
    290                 295                 300                 


Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile Ile 
305                 310                 315                 320 


Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser Gly 
                325                 330                 335     


Leu Gly Thr His His His His His His 
            340                 345 


<210>  35
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE Protein #2

<400>  35

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu 
            20                  25                  30          


Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu 
        35                  40                  45              


Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro 
    50                  55                  60                  


Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly 
65                  70                  75                  80  


Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg 
                85                  90                  95      


Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg 
            100                 105                 110         


Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser 
        115                 120                 125         


<210>  36
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE Protein #3

<400>  36

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu 
            20                  25                  30          


Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu 
        35                  40                  45              


Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro 
    50                  55                  60                  


Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly 
65                  70                  75                  80  


Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg 
                85                  90                  95      


Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg 
            100                 105                 110         


Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala 
        115                 120                 125             


Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser 
    130                 135                 140                 


Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys 
145                 150                 155                 160 


Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg 
                165                 170                 175     


Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val 
            180                 185                 190         


Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe 
        195                 200                 205             


Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln 
    210                 215                 220                 


Pro Arg Val Trp Glu Pro Val Pro 
225                 230         


<210>  37
<211>  334
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE Protein #4

<400>  37

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu 
            20                  25                  30          


Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu 
        35                  40                  45              


Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro 
    50                  55                  60                  


Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly 
65                  70                  75                  80  


Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg 
                85                  90                  95      


Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg 
            100                 105                 110         


Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala 
        115                 120                 125             


Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser 
    130                 135                 140                 


Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys 
145                 150                 155                 160 


Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg 
                165                 170                 175     


Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val 
            180                 185                 190         


Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe 
        195                 200                 205             


Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln 
    210                 215                 220                 


Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val 
225                 230                 235                 240 


Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr 
                245                 250                 255     


Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp 
            260                 265                 270         


Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu 
        275                 280                 285             


Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser 
    290                 295                 300                 


Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Glu 
305                 310                 315                 320 


Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 


<210>  38
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE Protein #5

<400>  38

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys 
            20                  25                  30          


Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser 
        35                  40                  45              


Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser 
    50                  55                  60                  


Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu 
65                  70                  75                  80  


Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro 
                85                  90                  95      


Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu 
            100                 105                 110         


Arg Thr Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro 
        115                 120                 125     


<210>  39
<211>  228
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE Protein #6

<400>  39

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys 
            20                  25                  30          


Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser 
        35                  40                  45              


Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser 
    50                  55                  60                  


Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu 
65                  70                  75                  80  


Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro 
                85                  90                  95      


Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu 
            100                 105                 110         


Arg Thr Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu 
        115                 120                 125             


Glu Val Gln Leu Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly 
    130                 135                 140                 


Gly Thr Val Thr Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln 
145                 150                 155                 160 


Ile His Trp Met Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro 
                165                 170                 175     


Val Leu Ile Leu Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser 
            180                 185                 190         


Cys Val Ala Thr His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val 
        195                 200                 205             


Ser Ile Ser Ile Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser 
    210                 215                 220                 


Val Gly Gly Ser 
225             


<210>  40
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  RAGE Protein #7

<400>  40

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu 
            20                  25                  30          


Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr Cys Glu Val 
        35                  40                  45              


Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp Gly Val Pro 
    50                  55                  60                  


Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu Ile Gly Pro 
65                  70                  75                  80  


Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser Ser His Gly 
                85                  90                  95      


Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Glu Pro Gly Glu 
            100                 105                 110         


Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
        115                 120             


<210>  41
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Ig gamma-1 constant region mutant

<400>  41

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  42
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  43
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  VH7-4.1/JH6 FR1

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  VH7-4.1/JH6 FR2

<400>  44

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  45
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  VH7-4.1/JH6 FR3

<400>  45

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  46
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  VH7-4.1/JH6 FR4

<400>  46

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  47
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  VH1-2/JH6 FR1

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  48
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  VH1-2/JH6 FR3

<400>  48

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  49
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  1-12/L5/JK2 FR1

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  50
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  1-12/L5/JK2 FR2

<400>  50

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  51
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  1-12/L5/JK2 FR3

<400>  51

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  52
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  1-12/L5/JK2 FR4

<400>  52

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  53
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  3-15/L2/JK2 FR1

<400>  53

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  54
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  3-15/L2/JK2 FR2

<400>  54

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  55
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  3-15/L2/JK2 FR3

<400>  55

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  56
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  VH 11E6.1-GL

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Asn Thr Gly Glu Ser Ile Tyr Ser Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Met Val Thr Ala Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  57
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  VH 11E6.2-GL

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Asn Thr Gly Glu Ser Ile Tyr Ser Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Met Val Thr Ala Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  58
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL 11E6.1-GL

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  59
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL 11E6.2-GL

<400>  59

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  60
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  61
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  hus RAGE Fragment

<400>  61

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly 
                325                 330     


<210>  62
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  VH h11E6.1

<400>  62

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Asn Thr Gly Glu Ser Ile Tyr Ser Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Met Val Thr Ala Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  63
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL h11E6.1

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  64
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL h11E6.2

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  65
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL h11E6.3

<400>  65

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  66
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL h11E6.4

<400>  66

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  67
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  VH h11E6.5

<400>  67

Glu Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Asn Thr Gly Glu Ser Ile Tyr Ser Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Arg Met Val Thr Ala Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  68
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  VH h11E6.9

<400>  68

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Asn Thr Gly Glu Ser Ile Tyr Ser Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Met Val Thr Ala Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  VH h11E6.13

<400>  69

Glu Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Thr Asn Thr Gly Glu Ser Ile Tyr Ser Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Arg Met Val Thr Ala Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  70
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  NtermR31

<400>  70

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30      


<210>  71
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 1

<400>  71

Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln 
1               5                   10                  15      


Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn 
            20                  25                  30  


<210>  72
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 2

<400>  72

Leu Pro Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu 
1               5                   10                  15      


Gly Ile Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu 
            20                  25                  30  


<210>  73
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 3

<400>  73

Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile Pro 
1               5                   10                  15      


Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala 
            20                  25                  30  


<210>  74
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 4

<400>  74

Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly 
1               5                   10                  15      


Ser Tyr Pro Ala Gly Thr Leu Ser Trp Lys Leu Asp Gly Lys 
            20                  25                  30  


<210>  75
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 5

<400>  75

Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu 
1               5                   10                  15      


Gln Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln 
            20                  25                  30  


<210>  76
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 6

<400>  76

Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly Gly Asp Pro 
1               5                   10                  15      


Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg 
            20                  25                  30  


<210>  77
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 7

<400>  77

Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val 
1               5                   10                  15      


Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu 
            20                  25                  30  


<210>  78
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 8

<400>  78

Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
1               5                   10                  15      


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His 
            20                  25                  30  


<210>  79
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 9

<400>  79

Gln Ile His Trp Met Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser 
1               5                   10                  15      


Pro Val Leu Ile Leu Pro Glu Ile Gly Pro Gln Asp Gln Gly 
            20                  25                  30  


<210>  80
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 10

<400>  80

Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser Ser His Gly Pro 
1               5                   10                  15      


Gln Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Glu Pro Gly 
            20                  25                  30  


<210>  81
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  PCR Primer

<400>  81

Cys Cys Gly Ala Ala Thr Thr Cys Cys Gly Gly Ala Ala Gly Cys Ala 
1               5                   10                  15      


Gly Gly Ala Thr Gly Gly Cys Ala Gly Cys Cys Gly 
            20                  25              


<210>  82
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  PCR Primer

<400>  82

Cys Cys Cys Thr Cys Gly Ala Gly Cys Cys Cys Cys Thr Cys Ala Ala 
1               5                   10                  15      


Gly Gly Cys Cys Cys Thr Cys Ala Gly Thr Ala Cys Thr Ala Cys Thr 
            20                  25                  30          


<210>  83
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  83
agtaacggcc gccagtgtgc tggaattcgg a                                    31


<210>  84
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  PCR Primer

<400>  84

Cys Cys Gly Gly Thr Ala Cys Cys Ala Cys Cys Thr Gly Cys Ala Gly 
1               5                   10                  15      


Thr Thr Gly Gly Cys Cys Cys Cys Thr Cys Cys Thr Cys Gly Cys Cys 
            20                  25                  30          


<210>  85
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  85
cgaagcttga tgaacaggaa tggaaaggag accaag                               36


<210>  86
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  86
tcctcgagca cctgcagttg gcccctcctc gcct                                 34


<210>  87
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  87
gcaccatggc agccggaaca gcagttg                                         27


<210>  88
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  88
gagtctcgag gcagaatcta caatttctg                                       29


<210>  89
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  89
atgctacata tgaaaaagac agctatcgcg attgcagtgg cactggctgg tttcgctacc     60

gtagcgcagg ccgctcaaaa catcacagcc                                      90


<210>  90
<211>  79
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  90
atgctactcg agtcagtggt ggtggtggtg gtgagttccc agccctgatc ctcccacaga     60

gcctgcagtt ggcccctcc                                                  79


<210>  91
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  91
gtacgatatc gagggacgaa tggatccacc gtgcccagca cc                        42


<210>  92
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  92
ctagtctaga tcatttaccc ggagacaggg ag                                   32


<210>  93
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  93
gtacgatatc gagggacgaa tggatccacc gtgcccagca cc                        42


<210>  94
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  PCR Primer

<400>  94
ctagtctaga tcatttaccc ggagacaggg ag                                   32


