                         SEQUENCE LISTING

<110>  Zhou, Pengbo
 
<120>  SUBSTANCES AND COMPOSITIONS FOR ENHANCING DNA REPAIR AND METHODS OF USE

<130>  704595

<150>  61/048,868
<151>  2008-04-29

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  759
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  CUL4A

<400>  1

Met Ala Asp Glu Ala Pro Arg Lys Gly Ser Phe Ser Ala Leu Val Gly 
1               5                   10                  15      


Arg Thr Asn Gly Leu Thr Lys Pro Ala Ala Leu Ala Ala Ala Pro Ala 
            20                  25                  30          


Lys Pro Gly Gly Ala Gly Gly Ser Lys Lys Leu Val Ile Lys Asn Phe 
        35                  40                  45              


Arg Asp Arg Pro Arg Leu Pro Asp Asn Tyr Thr Gln Asp Thr Trp Arg 
    50                  55                  60                  


Lys Leu His Glu Ala Val Arg Ala Val Gln Ser Ser Thr Ser Ile Arg 
65                  70                  75                  80  


Tyr Asn Leu Glu Glu Leu Tyr Gln Ala Val Glu Asn Leu Cys Ser His 
                85                  90                  95      


Lys Val Ser Pro Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp 
            100                 105                 110         


His Val Gln Ala Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser 
        115                 120                 125             


Val Leu Phe Leu Lys Lys Ile Asn Thr Cys Trp Gln Asp His Cys Arg 
    130                 135                 140                 


Gln Met Ile Met Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Thr Tyr 
145                 150                 155                 160 


Val Leu Gln Asn Ser Thr Leu Pro Ser Ile Trp Asp Met Gly Leu Glu 
                165                 170                 175     


Leu Phe Arg Thr His Ile Ile Ser Asp Lys Met Val Gln Ser Lys Thr 
            180                 185                 190         


Ile Asp Gly Ile Leu Leu Leu Ile Glu Arg Glu Arg Ser Gly Glu Ala 
        195                 200                 205             


Val Asp Arg Ser Leu Leu Arg Ser Leu Leu Gly Met Leu Ser Asp Leu 
    210                 215                 220                 


Gln Val Tyr Lys Asp Ser Phe Glu Leu Lys Phe Leu Glu Glu Thr Asn 
225                 230                 235                 240 


Cys Leu Tyr Ala Ala Glu Gly Gln Arg Leu Met Gln Glu Arg Glu Val 
                245                 250                 255     


Pro Glu Tyr Leu Asn His Val Ser Lys Arg Leu Glu Glu Glu Gly Asp 
            260                 265                 270         


Arg Val Ile Thr Tyr Leu Asp His Ser Thr Gln Lys Pro Leu Ile Ala 
        275                 280                 285             


Cys Val Glu Lys Gln Leu Leu Gly Glu His Leu Thr Ala Ile Leu Gln 
    290                 295                 300                 


Lys Gly Leu Asp His Leu Leu Asp Glu Asn Arg Val Pro Asp Leu Ala 
305                 310                 315                 320 


Gln Met Tyr Gln Leu Phe Ser Arg Val Arg Gly Gly Gln Gln Ala Leu 
                325                 330                 335     


Leu Gln His Trp Ser Glu Tyr Ile Lys Thr Phe Gly Thr Ala Ile Val 
            340                 345                 350         


Ile Asn Pro Glu Lys Asp Lys Asp Met Val Gln Asp Leu Leu Asp Phe 
        355                 360                 365             


Lys Asp Lys Val Asp His Val Ile Glu Val Cys Phe Gln Lys Asn Glu 
    370                 375                 380                 


Arg Phe Val Asn Leu Met Lys Glu Ser Phe Glu Thr Phe Ile Asn Lys 
385                 390                 395                 400 


Arg Pro Asn Lys Pro Ala Glu Leu Ile Ala Lys His Val Asp Ser Lys 
                405                 410                 415     


Leu Arg Ala Gly Asn Lys Glu Ala Thr Asp Glu Glu Leu Glu Arg Thr 
            420                 425                 430         


Leu Asp Lys Ile Met Ile Leu Phe Arg Phe Ile His Gly Lys Asp Val 
        435                 440                 445             


Phe Glu Ala Phe Tyr Lys Lys Asp Leu Ala Lys Arg Leu Leu Val Gly 
    450                 455                 460                 


Lys Ser Ala Ser Val Asp Ala Glu Lys Ser Met Leu Ser Lys Leu Lys 
465                 470                 475                 480 


His Glu Cys Gly Ala Ala Phe Thr Ser Lys Leu Glu Gly Met Phe Lys 
                485                 490                 495     


Asp Met Glu Leu Ser Lys Asp Ile Met Val His Phe Lys Gln His Met 
            500                 505                 510         


Gln Asn Gln Ser Asp Ser Gly Pro Ile Asp Leu Thr Val Asn Ile Leu 
        515                 520                 525             


Thr Met Gly Tyr Trp Pro Thr Tyr Thr Pro Met Glu Val His Leu Thr 
    530                 535                 540                 


Pro Glu Met Ile Lys Leu Gln Glu Val Phe Lys Ala Phe Tyr Leu Gly 
545                 550                 555                 560 


Lys His Ser Gly Arg Lys Leu Gln Trp Gln Thr Thr Leu Gly His Ala 
                565                 570                 575     


Val Leu Lys Ala Glu Phe Lys Glu Gly Lys Lys Glu Phe Gln Val Ser 
            580                 585                 590         


Leu Phe Gln Thr Leu Val Leu Leu Met Phe Asn Glu Gly Asp Gly Phe 
        595                 600                 605             


Ser Phe Glu Glu Ile Lys Met Ala Thr Gly Ile Glu Asp Ser Glu Leu 
    610                 615                 620                 


Arg Arg Thr Leu Gln Ser Leu Ala Cys Gly Lys Ala Arg Val Leu Ile 
625                 630                 635                 640 


Lys Ser Pro Lys Gly Lys Glu Val Glu Asp Gly Asp Lys Phe Ile Phe 
                645                 650                 655     


Asn Gly Glu Phe Lys His Lys Leu Phe Arg Ile Lys Ile Asn Gln Ile 
            660                 665                 670         


Gln Met Lys Glu Thr Val Glu Glu Gln Val Ser Thr Thr Glu Arg Val 
        675                 680                 685             


Phe Gln Asp Arg Gln Tyr Gln Ile Asp Ala Ala Ile Val Arg Ile Met 
    690                 695                 700                 


Lys Met Arg Lys Thr Leu Gly His Asn Leu Leu Val Ser Glu Leu Tyr 
705                 710                 715                 720 


Asn Gln Leu Lys Phe Pro Val Lys Pro Gly Asp Leu Lys Lys Arg Ile 
                725                 730                 735     


Glu Ser Leu Ile Asp Arg Asp Tyr Met Glu Arg Asp Lys Asp Asn Pro 
            740                 745                 750         


Asn Gln Tyr His Tyr Val Ala 
        755                 


<210>  2
<211>  3797
<212>  DNA
<213>  Homo sapiens

<220>  
<223>  Cul4a

<400>  2
ccggcccagc catggcggac gaggccccgc ggaagggcag cttctcggcg ctcgtgggcc       60

gcaccaacgg cctcaccaag cccgcggccc tggccgccgc gcccgccaag ccggggggcg      120

cgggcggctc caagaagctg gtcatcaaga acttccgaga cagacctcgg ctgcccgaca      180

actacacgca ggacacgtgg cggaagctgc acgaggcggt gcgggccgtg cagagcagca      240

cctccatcag gtacaacctc gaggagctct accaggctgt ggaaaatctc tgttctcaca      300

aagtctcccc aatgctctac aagcaactgc gtcaggcctg tgaagaccac gtccaggcac      360

agatccttcc gtttagagaa gactcactag atagtgtttt atttttaaag aagattaaca      420

cgtgctggca ggaccactgc agacaaatga tcatgatcag aagcatcttc ctgttcttgg      480

accgcaccta tgtgctgcag aactccacgc tgccctccat ctgggatatg ggattagaac      540

tgtttagaac ccatattatt agtgataaaa tggttcagag taaaaccatt gatggaatcc      600

tactgctgat cgagcgcgag aggagcggcg aggccgtgga ccggagcctg ttgcggagcc      660

tcctgggcat gctgtctgac ctgcaggtgt ataaagattc atttgaactg aaatttttgg      720

aagagactaa ttgcttatat gctgccgaag gccaaaggtt aatgcaggaa agagaggttc      780

cagaatatct taaccatgta agtaaacgct tagaggaaga gggagacaga gtaatcactt      840

acttggacca cagcacacag aaaccactga ttgcttgtgt ggagaaacag ctattaggag      900

aacatttaac agcaattctg cagaaagggc tcgaccactt actggatgag aacagagtgc      960

cggacctcgc acagatgtac cagctgttca gccgggtgag gggcgggcag caggcgctgc     1020

tgcagcactg gagcgagtac atcaagactt ttggaacagc gatcgtaatc aatcctgaga     1080

aagacaaaga catggtccaa gacctgttgg acttcaagga caaggtggac cacgtgatcg     1140

aggtctgctt ccagaagaat gagcggttcg tcaacctgat gaaggagtcc tttgagacgt     1200

tcatcaacaa gagacccaac aagcctgcag aactgatcgc aaagcatgtg gattcaaagt     1260

taagagcagg caacaaagaa gccacagacg aggagctgga gcggacgttg gacaagatca     1320

tgatcctgtt caggtttatc cacggtaaag atgtctttga agcattttat aaaaaagatt     1380

tggcaaaaag actccttgtt gggaaaagtg cctcagtcga tgctgaaaag tctatgttgt     1440

caaagctcaa gcatgagtgc ggtgcagcct tcaccagcaa gctggaaggc atgttcaagg     1500

acatggagct ttcgaaggac atcatggttc atttcaagca gcatatgcag aatcagagtg     1560

actcaggccc tatagacctc acagtgaaca tactcacaat gggctactgg ccaacataca     1620

cgcccatgga agtgcactta accccagaaa tgattaaact tcaggaagta tttaaggcat     1680

tttatcttgg aaagcacagt ggtcgaaaac ttcagtggca aactactttg ggacatgctg     1740

ttttaaaagc ggagtttaaa gaagggaaga aggaattcca ggtgtccctc ttccagacac     1800

tggtgctcct catgttcaac gagggagatg gcttcagctt tgaggagata aaaatggcca     1860

cggggataga ggatagtgaa ttgcgcagaa cgctgcagtc cctggcctgt ggcaaagcac     1920

gtgtgctgat taaaagtccc aaaggaaagg aagtggaaga tggagacaag ttcattttta     1980

atggagagtt caagcacaag ttgtttagaa taaagatcaa tcaaattcag atgaaggaaa     2040

ctgttgagga acaggttagc accactgaga gagtgtttca ggatagacaa tatcagattg     2100

atgctgctat cgtcagaata atgaagatga gaaagactct tggtcataat cttctagttt     2160

ctgaattata taatcagctg aaatttccag taaagcctgg agatttgaaa aagagaattg     2220

aatctctgat agacagagac tatatggaga gagacaaaga caatccgaat cagtaccact     2280

acgtggcctg acgcatctgc agacggttcc ccttcatgaa acactagaat gtaccctcag     2340

agcaggaagc acacctgtgc catttctggg actctgattg atccagctgt ggacattgga     2400

aggcgaagga agggaggtgg ctcctgggtc atctttcaca aggctcaaga cttcaacctg     2460

cagatgtatc tttttccctc cagtttttcc tctagttctt ttaggcattt aaattgtttc     2520

tgttactctg tgcaaaataa ctttgagatt ggacaagaag atgttactaa agagaagttc     2580

ctttaaaagg tcttgttctt gtgtcaaaaa gctgcaagtt tggtttgttc tcgtgtgtga     2640

tcatgagtgc acaatgaaga agaccctaga tgctgcattt tttagctctg aagattcctt     2700

aggtatccct gaagacagct cgctcagatg atcagcattt agagtgaaaa caagggccct     2760

tcatgggtga acattagaaa gagccagggt tcaaagctgg cgaatggatg acgcacccta     2820

gccactggcc cctctctgtt tcatgtattt ccaaaagttg taaactttga tggctgattt     2880

ttcgtaagtc aggtttctaa gtgagctccc tgaggtgcca aggccatggt gtccgccctg     2940

ctgcgtctgt tcgtcagctg agttccttgt gaatctctgt tttagggttt ggggctagtg     3000

tgtttgtgtt tccattctaa gattgagtct ggcagtccct gtttttttgc attggggtaa     3060

ctgctctttg atttttttta attgcagtat ttgtgtgatt gcaataataa agtttggttt     3120

ggtttttaca gtcatgcgca gggacgatcc ttgttctctg ctgtaaactg taaaaagttt     3180

atggagactt aaagtcttga tgttgtgaag cagaggttat tttgtggaaa gattaaaagg     3240

attttgttgg tacctggttt tgtgttgtgt atatatacat gaggttgaac agtgaaagga     3300

aagttcagta gtgatgttag aagggtaact atgacaaaga tacttttgag ataacattta     3360

aaagtacttt atattttaca taatagcatg tttcattttg attaaaagct accaaaggaa     3420

ttttgatcat ggcataagtg tttaaagcaa tattttctgg aatataccaa gtttatataa     3480

tttgattttg tgctaaatta ttaagagtct ctttttgaaa catgcgggtt tgaaatatga     3540

caccttgtgg gtttccatat taaaatcctc actctttaat tgtcatttct atctttgaaa     3600

attttcattt atgagttcca tgatatgtgg tctaagaaag accaaacaga tttctatttt     3660

ttttttctta taagttcgtt gtgtctagag attgttaata ttgtaattta atgtagactt     3720

actttgaata aaattagttt aattggcctt aaaattacat taataaaact ttgtgatatg     3780

caaatgaaaa aaaaaaa                                                    3797


<210>  3
<211>  1140
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  DDB1 (p127)

<400>  3

Met Ser Tyr Asn Tyr Val Val Thr Ala Gln Lys Pro Thr Ala Val Asn 
1               5                   10                  15      


Gly Cys Val Thr Gly His Phe Thr Ser Ala Glu Asp Leu Asn Leu Leu 
            20                  25                  30          


Ile Ala Lys Asn Thr Arg Leu Glu Ile Tyr Val Val Thr Ala Glu Gly 
        35                  40                  45              


Leu Arg Pro Val Lys Glu Val Gly Met Tyr Gly Lys Ile Ala Val Met 
    50                  55                  60                  


Glu Leu Phe Arg Pro Lys Gly Glu Ser Lys Asp Leu Leu Phe Ile Leu 
65                  70                  75                  80  


Thr Ala Lys Tyr Asn Ala Cys Ile Leu Glu Tyr Lys Gln Ser Gly Glu 
                85                  90                  95      


Ser Ile Asp Ile Ile Thr Arg Ala His Gly Asn Val Gln Asp Arg Ile 
            100                 105                 110         


Gly Arg Pro Ser Glu Thr Gly Ile Ile Gly Ile Ile Asp Pro Glu Cys 
        115                 120                 125             


Arg Met Ile Gly Leu Arg Leu Tyr Asp Gly Leu Phe Lys Val Ile Pro 
    130                 135                 140                 


Leu Asp Arg Asp Asn Lys Glu Leu Lys Ala Phe Asn Ile Arg Leu Glu 
145                 150                 155                 160 


Glu Leu His Val Ile Asp Val Lys Phe Leu Tyr Gly Cys Gln Ala Pro 
                165                 170                 175     


Thr Ile Cys Phe Val Tyr Gln Asp Pro Gln Gly Arg His Val Lys Thr 
            180                 185                 190         


Tyr Glu Val Ser Leu Arg Glu Lys Glu Phe Asn Lys Gly Pro Trp Lys 
        195                 200                 205             


Gln Glu Asn Val Glu Ala Glu Ala Ser Met Val Ile Ala Val Pro Glu 
    210                 215                 220                 


Pro Phe Gly Gly Ala Ile Ile Ile Gly Gln Glu Ser Ile Thr Tyr His 
225                 230                 235                 240 


Asn Gly Asp Lys Tyr Leu Ala Ile Ala Pro Pro Ile Ile Lys Gln Ser 
                245                 250                 255     


Thr Ile Val Cys His Asn Arg Val Asp Pro Asn Gly Ser Arg Tyr Leu 
            260                 265                 270         


Leu Gly Asp Met Glu Gly Arg Leu Phe Met Leu Leu Leu Glu Lys Glu 
        275                 280                 285             


Glu Gln Met Asp Gly Thr Val Thr Leu Lys Asp Leu Arg Val Glu Leu 
    290                 295                 300                 


Leu Gly Glu Thr Ser Ile Ala Glu Cys Leu Thr Tyr Leu Asp Asn Gly 
305                 310                 315                 320 


Val Val Phe Val Gly Ser Arg Leu Gly Asp Ser Gln Leu Val Lys Leu 
                325                 330                 335     


Asn Val Asp Ser Asn Glu Gln Gly Ser Tyr Val Val Ala Met Glu Thr 
            340                 345                 350         


Phe Thr Asn Leu Gly Pro Ile Val Asp Met Cys Val Val Asp Leu Glu 
        355                 360                 365             


Arg Gln Gly Gln Gly Gln Leu Val Thr Cys Ser Gly Ala Phe Lys Glu 
    370                 375                 380                 


Gly Ser Leu Arg Ile Ile Arg Asn Gly Ile Gly Ile His Glu His Ala 
385                 390                 395                 400 


Ser Ile Asp Leu Pro Gly Ile Lys Gly Leu Trp Pro Leu Arg Ser Asp 
                405                 410                 415     


Pro Asn Arg Glu Thr Asp Asp Thr Leu Val Leu Ser Phe Val Gly Gln 
            420                 425                 430         


Thr Arg Val Leu Met Leu Asn Gly Glu Glu Val Glu Glu Thr Glu Leu 
        435                 440                 445             


Met Gly Phe Val Asp Asp Gln Gln Thr Phe Phe Cys Gly Asn Val Ala 
    450                 455                 460                 


His Gln Gln Leu Ile Gln Ile Thr Ser Ala Ser Val Arg Leu Val Ser 
465                 470                 475                 480 


Gln Glu Pro Lys Ala Leu Val Ser Glu Trp Lys Glu Pro Gln Ala Lys 
                485                 490                 495     


Asn Ile Ser Val Ala Ser Cys Asn Ser Ser Gln Val Val Val Ala Val 
            500                 505                 510         


Gly Arg Ala Leu Tyr Tyr Leu Gln Ile His Pro Gln Glu Leu Arg Gln 
        515                 520                 525             


Ile Ser His Thr Glu Met Glu His Glu Val Ala Cys Leu Asp Ile Thr 
    530                 535                 540                 


Pro Leu Gly Asp Ser Asn Gly Leu Ser Pro Leu Cys Ala Ile Gly Leu 
545                 550                 555                 560 


Trp Thr Asp Ile Ser Ala Arg Ile Leu Lys Leu Pro Ser Phe Glu Leu 
                565                 570                 575     


Leu His Lys Glu Met Leu Gly Gly Glu Ile Ile Pro Arg Ser Ile Leu 
            580                 585                 590         


Met Thr Thr Phe Glu Ser Ser His Tyr Leu Leu Cys Ala Leu Gly Asp 
        595                 600                 605             


Gly Ala Leu Phe Tyr Phe Gly Leu Asn Ile Glu Thr Gly Leu Leu Ser 
    610                 615                 620                 


Asp Arg Lys Lys Val Thr Leu Gly Thr Gln Pro Thr Val Leu Arg Thr 
625                 630                 635                 640 


Phe Arg Ser Leu Ser Thr Thr Asn Val Phe Ala Cys Ser Asp Arg Pro 
                645                 650                 655     


Thr Val Ile Tyr Ser Ser Asn His Lys Leu Val Phe Ser Asn Val Asn 
            660                 665                 670         


Leu Lys Glu Val Asn Tyr Met Cys Pro Leu Asn Ser Asp Gly Tyr Pro 
        675                 680                 685             


Asp Ser Leu Ala Leu Ala Asn Asn Ser Thr Leu Thr Ile Gly Thr Ile 
    690                 695                 700                 


Asp Glu Ile Gln Lys Leu His Ile Arg Thr Val Pro Leu Tyr Glu Ser 
705                 710                 715                 720 


Pro Arg Lys Ile Cys Tyr Gln Glu Val Ser Gln Cys Phe Gly Val Leu 
                725                 730                 735     


Ser Ser Arg Ile Glu Val Gln Asp Thr Ser Gly Gly Thr Thr Ala Leu 
            740                 745                 750         


Arg Pro Ser Ala Ser Thr Gln Ala Leu Ser Ser Ser Val Ser Ser Ser 
        755                 760                 765             


Lys Leu Phe Ser Ser Ser Thr Ala Pro His Glu Thr Ser Phe Gly Glu 
    770                 775                 780                 


Glu Val Glu Val His Asn Leu Leu Ile Ile Asp Gln His Thr Phe Glu 
785                 790                 795                 800 


Val Leu His Ala His Gln Phe Leu Gln Asn Glu Tyr Ala Leu Ser Leu 
                805                 810                 815     


Val Ser Cys Lys Leu Gly Lys Asp Pro Asn Thr Tyr Phe Ile Val Gly 
            820                 825                 830         


Thr Ala Met Val Tyr Pro Glu Glu Ala Glu Pro Lys Gln Gly Arg Ile 
        835                 840                 845             


Val Val Phe Gln Tyr Ser Asp Gly Lys Leu Gln Thr Val Ala Glu Lys 
    850                 855                 860                 


Glu Val Lys Gly Ala Val Tyr Ser Met Val Glu Phe Asn Gly Lys Leu 
865                 870                 875                 880 


Leu Ala Ser Ile Asn Ser Thr Val Arg Leu Tyr Glu Trp Thr Thr Glu 
                885                 890                 895     


Lys Glu Leu Arg Thr Glu Cys Asn His Tyr Asn Asn Ile Met Ala Leu 
            900                 905                 910         


Tyr Leu Lys Thr Lys Gly Asp Phe Ile Leu Val Gly Asp Leu Met Arg 
        915                 920                 925             


Ser Val Leu Leu Leu Ala Tyr Lys Pro Met Glu Gly Asn Phe Glu Glu 
    930                 935                 940                 


Ile Ala Arg Asp Phe Asn Pro Asn Trp Met Ser Ala Val Glu Ile Leu 
945                 950                 955                 960 


Asp Asp Asp Asn Phe Leu Gly Ala Glu Asn Ala Phe Asn Leu Phe Val 
                965                 970                 975     


Cys Gln Lys Asp Ser Ala Ala Thr Thr Asp Glu Glu Arg Gln His Leu 
            980                 985                 990         


Gln Glu Val Gly Leu Phe His Leu  Gly Glu Phe Val Asn  Val Phe Cys 
        995                 1000                 1005             


His Gly  Ser Leu Val Met Gln  Asn Leu Gly Glu Thr  Ser Thr Pro 
    1010                 1015                 1020             


Thr Gln  Gly Ser Val Leu Phe  Gly Thr Val Asn Gly  Met Ile Gly 
    1025                 1030                 1035             


Leu Val  Thr Ser Leu Ser Glu  Ser Trp Tyr Asn Leu  Leu Leu Asp 
    1040                 1045                 1050             


Met Gln  Asn Arg Leu Asn Lys  Val Ile Lys Ser Val  Gly Lys Ile 
    1055                 1060                 1065             


Glu His  Ser Phe Trp Arg Ser  Phe His Thr Glu Arg  Lys Thr Glu 
    1070                 1075                 1080             


Pro Ala  Thr Gly Phe Ile Asp  Gly Asp Leu Ile Glu  Ser Phe Leu 
    1085                 1090                 1095             


Asp Ile  Ser Arg Pro Lys Met  Gln Glu Val Val Ala  Asn Leu Gln 
    1100                 1105                 1110             


Tyr Asp  Asp Gly Ser Gly Met  Lys Arg Glu Ala Thr  Ala Asp Asp 
    1115                 1120                 1125             


Leu Ile  Lys Val Val Glu Glu  Leu Thr Arg Ile His  
    1130                 1135                 1140 


<210>  4
<211>  4355
<212>  DNA
<213>  Homo sapiens

<220>  
<223>  Ddb1

<400>  4
gcctccttcg gttggcggcc tcgggcttcg ggagtcctcc aagaggccag gtgaggccgt       60

cccgtgatgc cccgcgcccc ggccgctctg gcctgcaacg tgtctctggg gcggaggcag      120

cggcagtgga gttcgctgcg cgctgttggg ggccacctgt cttttcgctt gtgtccctct      180

ttctagtgtc gcgctcgagt cccgacgggc cgctccaagc ctcgacatgt cgtacaacta      240

cgtggtaacg gcccagaagc ccaccgccgt gaacggctgc gtgaccggac actttacttc      300

ggccgaagac ttaaacctgt tgattgccaa aaacacgaga ttagagatct atgtggtcac      360

cgccgagggg cttcggcccg tcaaagaggt gggcatgtat gggaagattg cggtcatgga      420

gcttttcagg cccaaggggg agagcaagga cctgctgttt atcttgacag cgaagtacaa      480

tgcctgcatc ctggagtata aacagagtgg cgagagcatt gacatcatta cgcgagccca      540

tggcaatgtc caggaccgca ttggccgccc ctcagagacc ggcattattg gcatcattga      600

ccctgagtgc cggatgattg gcctgcgtct ctatgatggc cttttcaagg ttattccact      660

agatcgcgat aataaagaac tcaaggcctt caacatccgc ctggaggagc tgcatgtcat      720

tgatgtcaag ttcctatatg gttgccaagc acctactatt tgctttgtct accaggaccc      780

tcaggggcgg cacgtaaaaa cctatgaggt gtctctccga gaaaaggaat tcaataaggg      840

cccttggaaa caggaaaatg tcgaagctga agcttccatg gtgatcgcag tcccagagcc      900

ctttgggggg gccatcatca ttggacagga gtcaatcacc tatcacaatg gtgacaaata      960

cctggctatt gcccctccta tcatcaagca aagcacgatt gtgtgccaca atcgagtgga     1020

ccctaatggc tcaagatacc tgctgggaga catggaaggc cggctcttca tgctgctttt     1080

ggagaaggag gaacagatgg atggcaccgt cactctcaag gatctccgtg tagaactcct     1140

tggagagacc tctattgctg agtgcttgac ataccttgat aatggtgttg tgtttgtcgg     1200

gtctcgcctg ggtgactccc agcttgtgaa gctcaacgtt gacagtaatg aacaaggctc     1260

ctatgtagtg gccatggaaa cctttaccaa cttaggaccc attgtcgata tgtgcgtggt     1320

ggacctggag aggcaggggc aggggcagct ggtcacttgc tctggggctt tcaaggaagg     1380

ttctttgcgg atcatccgga atggaattgg aatccacgag catgccagca ttgacttacc     1440

aggcatcaaa ggattatggc cactgcggtc tgaccctaat cgtgagactg atgacacttt     1500

ggtgctctct tttgtgggcc agacaagagt tctcatgtta aatggagagg aggtagaaga     1560

aaccgaactg atgggtttcg tggatgatca gcagactttc ttctgtggca acgtggctca     1620

tcagcagctt atccagatca cttcagcatc ggtgaggttg gtctctcaag aacccaaagc     1680

tctggtcagt gaatggaagg agcctcaggc caagaacatc agtgtggcct cctgcaatag     1740

cagccaggtg gtggtggctg taggcagggc cctctactat ctgcagatcc atcctcagga     1800

gctccggcag atcagccaca cagagatgga acatgaagtg gcttgcttgg acatcacccc     1860

attaggagac agcaatggac tgtcccctct ttgtgccatt ggcctctgga cggacatctc     1920

ggctcgtatc ttgaagttgc cctcttttga actactgcac aaggagatgc tgggtggaga     1980

gatcattcct cgctccatcc tgatgaccac ctttgagagt agccattacc tcctttgtgc     2040

cttgggagat ggagcgcttt tctactttgg gctcaacatt gagacaggtc tgttgagcga     2100

ccgtaagaag gtgactttgg gcacccagcc caccgtattg aggacttttc gttctctttc     2160

taccaccaac gtctttgctt gttctgaccg ccccactgtc atctatagca gcaaccacaa     2220

attggtcttc tcaaatgtca acctcaagga agtgaactac atgtgtcccc tcaattcaga     2280

tggctatcct gacagcctgg cgctggccaa caatagcacc ctcaccattg gcaccatcga     2340

tgagatccag aagctgcaca ttcgcacagt tcccctctat gagtctccaa ggaagatctg     2400

ctaccaggaa gtgtcccagt gtttcggggt cctctccagc cgcattgaag tccaagacac     2460

gagtgggggc acgacagcct tgaggcccag cgctagcacc caggctctgt ccagcagtgt     2520

aagctccagc aagctgttct ccagcagcac tgctcctcat gagacctcct ttggagaaga     2580

ggtggaggtg cacaacctac ttatcattga ccaacacacc tttgaagtgc ttcatgccca     2640

ccagtttctg cagaatgaat atgccctcag tctggtttcc tgcaagctgg gcaaagaccc     2700

caacacttac ttcattgtgg gcacagcaat ggtgtatcct gaagaggcag agcccaagca     2760

gggtcgcatt gtggtctttc agtattcgga tggaaaacta cagactgtgg ctgaaaagga     2820

agtgaaaggg gccgtgtact ctatggtgga atttaacggg aagctgttag ccagcatcaa     2880

tagcacggtg cggctctatg agtggacaac agagaaggag ctgcgcactg agtgcaacca     2940

ctacaacaac atcatggccc tctacctgaa gaccaagggc gacttcatcc tggtgggcga     3000

ccttatgcgc tcagtgctgc tgcttgccta caagcccatg gaaggaaact ttgaagagat     3060

tgctcgagac tttaatccca actggatgag tgctgtggaa atcttggatg atgacaattt     3120

tctgggggct gaaaatgcct ttaacttgtt tgtgtgtcaa aaggatagcg ctgccaccac     3180

tgacgaggag cggcagcacc tccaggaggt tggtcttttc cacctgggcg agtttgtcaa     3240

tgtcttttgc cacggctctc tggtaatgca gaatctgggt gagacttcca cccccacaca     3300

aggctcggtg ctcttcggca cggtcaacgg catgataggg ctggtgacct cactgtcaga     3360

gagctggtac aacctcctgc tggacatgca gaatcgactc aataaagtca tcaaaagtgt     3420

ggggaagatc gagcactcct tctggagatc ctttcacacc gagcggaaga cagaaccagc     3480

cacaggtttc atcgacggtg acttgattga gagtttcctg gatattagcc gccccaagat     3540

gcaggaggtg gtggcaaacc tacagtatga cgatggcagc ggtatgaagc gagaggccac     3600

tgcagacgac ctcatcaagg ttgtggagga gctaactcgg atccattagc caagggcagg     3660

gggccccttt gctgaccctc cccaaaggct ttgccctgct gccctccccc tcctctccac     3720

catcgtcttc ttggccatgg gaggcctttc cctaagccag ctgcccccag agccacagtt     3780

cccctatgtg gaagtggggc gggcttcata gagacttggg aatgagctga aggtgaaaca     3840

ttttctccct ggatttttac cagtctcaca tgattccagc catcacctta gaccaccaag     3900

ccttgattgg tgttgccagt tgtcctcctt ccggggaagg attttgcagt tctttggctg     3960

aaaggaagct gtgcgtgtgt gtgtgtgtat gtgtgtgtgt gtatgtgtat ctcacactca     4020

tgcattgtcc tctttttatt tagattggca gtgtagggag ttgtgggtag tggggaagag     4080

ggttaggagg gtttcattgt ctgtgaagtg agaccttcct tttacttttc ttctattgcc     4140

tctgagagca tcaggcctag aggcctgact gccaagccat gggtagcctg ggtgtaaaac     4200

ctggagatgg tggatgatcc ccacgccaca gcccttttgt ctctgcaaac tgccttcttc     4260

ggaaagaaga aggtgggagg atgtgaattg ttagtttctg agttttacca aataaagtag     4320

aatataagaa gaaaggtaaa aaaaaaaaaa aaaaa                                4355


<210>  5
<211>  723
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  CUL4A fragment (A37-A759)

<400>  5

Ala Gly Gly Ser Lys Lys Leu Val Ile Lys Asn Phe Arg Asp Arg Pro 
1               5                   10                  15      


Arg Leu Pro Asp Asn Tyr Thr Gln Asp Thr Trp Arg Lys Leu His Glu 
            20                  25                  30          


Ala Val Arg Ala Val Gln Ser Ser Thr Ser Ile Arg Tyr Asn Leu Glu 
        35                  40                  45              


Glu Leu Tyr Gln Ala Val Glu Asn Leu Cys Ser His Lys Val Ser Pro 
    50                  55                  60                  


Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp His Val Gln Ala 
65                  70                  75                  80  


Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser Val Leu Phe Leu 
                85                  90                  95      


Lys Lys Ile Asn Thr Cys Trp Gln Asp His Cys Arg Gln Met Ile Met 
            100                 105                 110         


Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Thr Tyr Val Leu Gln Asn 
        115                 120                 125             


Ser Thr Leu Pro Ser Ile Trp Asp Met Gly Leu Glu Leu Phe Arg Thr 
    130                 135                 140                 


His Ile Ile Ser Asp Lys Met Val Gln Ser Lys Thr Ile Asp Gly Ile 
145                 150                 155                 160 


Leu Leu Leu Ile Glu Arg Glu Arg Ser Gly Glu Ala Val Asp Arg Ser 
                165                 170                 175     


Leu Leu Arg Ser Leu Leu Gly Met Leu Ser Asp Leu Gln Val Tyr Lys 
            180                 185                 190         


Asp Ser Phe Glu Leu Lys Phe Leu Glu Glu Thr Asn Cys Leu Tyr Ala 
        195                 200                 205             


Ala Glu Gly Gln Arg Leu Met Gln Glu Arg Glu Val Pro Glu Tyr Leu 
    210                 215                 220                 


Asn His Val Ser Lys Arg Leu Glu Glu Glu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Tyr Leu Asp His Ser Thr Gln Lys Pro Leu Ile Ala Cys Val Glu Lys 
                245                 250                 255     


Gln Leu Leu Gly Glu His Leu Thr Ala Ile Leu Gln Lys Gly Leu Asp 
            260                 265                 270         


His Leu Leu Asp Glu Asn Arg Val Pro Asp Leu Ala Gln Met Tyr Gln 
        275                 280                 285             


Leu Phe Ser Arg Val Arg Gly Gly Gln Gln Ala Leu Leu Gln His Trp 
    290                 295                 300                 


Ser Glu Tyr Ile Lys Thr Phe Gly Thr Ala Ile Val Ile Asn Pro Glu 
305                 310                 315                 320 


Lys Asp Lys Asp Met Val Gln Asp Leu Leu Asp Phe Lys Asp Lys Val 
                325                 330                 335     


Asp His Val Ile Glu Val Cys Phe Gln Lys Asn Glu Arg Phe Val Asn 
            340                 345                 350         


Leu Met Lys Glu Ser Phe Glu Thr Phe Ile Asn Lys Arg Pro Asn Lys 
        355                 360                 365             


Pro Ala Glu Leu Ile Ala Lys His Val Asp Ser Lys Leu Arg Ala Gly 
    370                 375                 380                 


Asn Lys Glu Ala Thr Asp Glu Glu Leu Glu Arg Thr Leu Asp Lys Ile 
385                 390                 395                 400 


Met Ile Leu Phe Arg Phe Ile His Gly Lys Asp Val Phe Glu Ala Phe 
                405                 410                 415     


Tyr Lys Lys Asp Leu Ala Lys Arg Leu Leu Val Gly Lys Ser Ala Ser 
            420                 425                 430         


Val Asp Ala Glu Lys Ser Met Leu Ser Lys Leu Lys His Glu Cys Gly 
        435                 440                 445             


Ala Ala Phe Thr Ser Lys Leu Glu Gly Met Phe Lys Asp Met Glu Leu 
    450                 455                 460                 


Ser Lys Asp Ile Met Val His Phe Lys Gln His Met Gln Asn Gln Ser 
465                 470                 475                 480 


Asp Ser Gly Pro Ile Asp Leu Thr Val Asn Ile Leu Thr Met Gly Tyr 
                485                 490                 495     


Trp Pro Thr Tyr Thr Pro Met Glu Val His Leu Thr Pro Glu Met Ile 
            500                 505                 510         


Lys Leu Gln Glu Val Phe Lys Ala Phe Tyr Leu Gly Lys His Ser Gly 
        515                 520                 525             


Arg Lys Leu Gln Trp Gln Thr Thr Leu Gly His Ala Val Leu Lys Ala 
    530                 535                 540                 


Glu Phe Lys Glu Gly Lys Lys Glu Phe Gln Val Ser Leu Phe Gln Thr 
545                 550                 555                 560 


Leu Val Leu Leu Met Phe Asn Glu Gly Asp Gly Phe Ser Phe Glu Glu 
                565                 570                 575     


Ile Lys Met Ala Thr Gly Ile Glu Asp Ser Glu Leu Arg Arg Thr Leu 
            580                 585                 590         


Gln Ser Leu Ala Cys Gly Lys Ala Arg Val Leu Ile Lys Ser Pro Lys 
        595                 600                 605             


Gly Lys Glu Val Glu Asp Gly Asp Lys Phe Ile Phe Asn Gly Glu Phe 
    610                 615                 620                 


Lys His Lys Leu Phe Arg Ile Lys Ile Asn Gln Ile Gln Met Lys Glu 
625                 630                 635                 640 


Thr Val Glu Glu Gln Val Ser Thr Thr Glu Arg Val Phe Gln Asp Arg 
                645                 650                 655     


Gln Tyr Gln Ile Asp Ala Ala Ile Val Arg Ile Met Lys Met Arg Lys 
            660                 665                 670         


Thr Leu Gly His Asn Leu Leu Val Ser Glu Leu Tyr Asn Gln Leu Lys 
        675                 680                 685             


Phe Pro Val Lys Pro Gly Asp Leu Lys Lys Arg Ile Glu Ser Leu Ile 
    690                 695                 700                 


Asp Arg Asp Tyr Met Glu Arg Asp Lys Asp Asn Pro Asn Gln Tyr His 
705                 710                 715                 720 


Tyr Val Ala 
            


<210>  6
<211>  365
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  CUL4A fragment (A37-R401)

<400>  6

Ala Gly Gly Ser Lys Lys Leu Val Ile Lys Asn Phe Arg Asp Arg Pro 
1               5                   10                  15      


Arg Leu Pro Asp Asn Tyr Thr Gln Asp Thr Trp Arg Lys Leu His Glu 
            20                  25                  30          


Ala Val Arg Ala Val Gln Ser Ser Thr Ser Ile Arg Tyr Asn Leu Glu 
        35                  40                  45              


Glu Leu Tyr Gln Ala Val Glu Asn Leu Cys Ser His Lys Val Ser Pro 
    50                  55                  60                  


Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp His Val Gln Ala 
65                  70                  75                  80  


Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser Val Leu Phe Leu 
                85                  90                  95      


Lys Lys Ile Asn Thr Cys Trp Gln Asp His Cys Arg Gln Met Ile Met 
            100                 105                 110         


Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Thr Tyr Val Leu Gln Asn 
        115                 120                 125             


Ser Thr Leu Pro Ser Ile Trp Asp Met Gly Leu Glu Leu Phe Arg Thr 
    130                 135                 140                 


His Ile Ile Ser Asp Lys Met Val Gln Ser Lys Thr Ile Asp Gly Ile 
145                 150                 155                 160 


Leu Leu Leu Ile Glu Arg Glu Arg Ser Gly Glu Ala Val Asp Arg Ser 
                165                 170                 175     


Leu Leu Arg Ser Leu Leu Gly Met Leu Ser Asp Leu Gln Val Tyr Lys 
            180                 185                 190         


Asp Ser Phe Glu Leu Lys Phe Leu Glu Glu Thr Asn Cys Leu Tyr Ala 
        195                 200                 205             


Ala Glu Gly Gln Arg Leu Met Gln Glu Arg Glu Val Pro Glu Tyr Leu 
    210                 215                 220                 


Asn His Val Ser Lys Arg Leu Glu Glu Glu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Tyr Leu Asp His Ser Thr Gln Lys Pro Leu Ile Ala Cys Val Glu Lys 
                245                 250                 255     


Gln Leu Leu Gly Glu His Leu Thr Ala Ile Leu Gln Lys Gly Leu Asp 
            260                 265                 270         


His Leu Leu Asp Glu Asn Arg Val Pro Asp Leu Ala Gln Met Tyr Gln 
        275                 280                 285             


Leu Phe Ser Arg Val Arg Gly Gly Gln Gln Ala Leu Leu Gln His Trp 
    290                 295                 300                 


Ser Glu Tyr Ile Lys Thr Phe Gly Thr Ala Ile Val Ile Asn Pro Glu 
305                 310                 315                 320 


Lys Asp Lys Asp Met Val Gln Asp Leu Leu Asp Phe Lys Asp Lys Val 
                325                 330                 335     


Asp His Val Ile Glu Val Cys Phe Gln Lys Asn Glu Arg Phe Val Asn 
            340                 345                 350         


Leu Met Lys Glu Ser Phe Glu Thr Phe Ile Asn Lys Arg 
        355                 360                 365 


<210>  7
<211>  144
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  CUL4A N-term (K41-S184)

<400>  7

Lys Lys Leu Val Ile Lys Asn Phe Arg Asp Arg Pro Arg Leu Pro Asp 
1               5                   10                  15      


Asn Tyr Thr Gln Asp Thr Trp Arg Lys Leu His Glu Ala Val Arg Ala 
            20                  25                  30          


Val Gln Ser Ser Thr Ser Ile Arg Tyr Asn Leu Glu Glu Leu Tyr Gln 
        35                  40                  45              


Ala Val Glu Asn Leu Cys Ser His Lys Val Ser Pro Met Leu Tyr Lys 
    50                  55                  60                  


Gln Leu Arg Gln Ala Cys Glu Asp His Val Gln Ala Gln Ile Leu Pro 
65                  70                  75                  80  


Phe Arg Glu Asp Ser Leu Asp Ser Val Leu Phe Leu Lys Lys Ile Asn 
                85                  90                  95      


Thr Cys Trp Gln Asp His Cys Arg Gln Met Ile Met Ile Arg Ser Ile 
            100                 105                 110         


Phe Leu Phe Leu Asp Arg Thr Tyr Val Leu Gln Asn Ser Thr Leu Pro 
        115                 120                 125             


Ser Ile Trp Asp Met Gly Leu Glu Leu Phe Arg Thr His Ile Ile Ser 
    130                 135                 140                 


<210>  8
<211>  319
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  BPB domain of DDB1

<400>  8

Arg Asn Gly Ile Gly Ile His Glu His Ala Ser Ile Asp Leu Pro Gly 
1               5                   10                  15      


Ile Lys Gly Leu Trp Pro Leu Arg Ser Asp Pro Asn Arg Glu Thr Asp 
            20                  25                  30          


Asp Thr Leu Val Leu Ser Phe Val Gly Gln Thr Arg Val Leu Met Leu 
        35                  40                  45              


Asn Gly Glu Glu Val Glu Glu Thr Glu Leu Met Gly Phe Val Asp Asp 
    50                  55                  60                  


Gln Gln Thr Phe Phe Cys Gly Asn Val Ala His Gln Gln Leu Ile Gln 
65                  70                  75                  80  


Ile Thr Ser Ala Ser Val Arg Leu Val Ser Gln Glu Pro Lys Ala Leu 
                85                  90                  95      


Val Ser Glu Trp Lys Glu Pro Gln Ala Lys Asn Ile Ser Val Ala Ser 
            100                 105                 110         


Cys Asn Ser Ser Gln Val Val Val Ala Val Gly Arg Ala Leu Tyr Tyr 
        115                 120                 125             


Leu Gln Ile His Pro Gln Glu Leu Arg Gln Ile Ser His Thr Glu Met 
    130                 135                 140                 


Glu His Glu Val Ala Cys Leu Asp Ile Thr Pro Leu Gly Asp Ser Asn 
145                 150                 155                 160 


Gly Leu Ser Pro Leu Cys Ala Ile Gly Leu Trp Thr Asp Ile Ser Ala 
                165                 170                 175     


Arg Ile Leu Lys Leu Pro Ser Phe Glu Leu Leu His Lys Glu Met Leu 
            180                 185                 190         


Gly Gly Glu Ile Ile Pro Arg Ser Ile Leu Met Thr Thr Phe Glu Ser 
        195                 200                 205             


Ser His Tyr Leu Leu Cys Ala Leu Gly Asp Gly Ala Leu Phe Tyr Phe 
    210                 215                 220                 


Gly Leu Asn Ile Glu Thr Gly Leu Leu Ser Asp Arg Lys Lys Val Thr 
225                 230                 235                 240 


Leu Gly Thr Gln Pro Thr Val Leu Arg Thr Phe Arg Ser Leu Ser Thr 
                245                 250                 255     


Thr Asn Val Phe Ala Cys Ser Asp Arg Pro Thr Val Ile Tyr Ser Ser 
            260                 265                 270         


Asn His Lys Leu Val Phe Ser Asn Val Asn Leu Lys Glu Val Asn Tyr 
        275                 280                 285             


Met Cys Pro Leu Asn Ser Asp Gly Tyr Pro Asp Ser Leu Ala Leu Ala 
    290                 295                 300                 


Asn Asn Ser Thr Leu Thr Ile Gly Thr Ile Asp Glu Ile Gln Lys 
305                 310                 315                 


<210>  9
<211>  21
<212>  DNA
<213>  Mus musculus

<220>  
<223>  Cul4b shRNA

<400>  9
gtagtaacga gagagaagac t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Mus musculus

<220>  
<223>  Pcid2 shRNA-1

<400>  10
ggcaaagcac gagacgttct t                                                 21


<210>  11
<211>  22
<212>  DNA
<213>  Mus musculus

<220>  
<223>  Pcid2 shRNA-2 

<400>  11
gatgaaatgt ttgcagctca tt                                                22


<210>  12
<211>  22
<212>  DNA
<213>  Mus musculus

<220>  
<223>  p21 shRNA

<400>  12
gagaacggtg gaactttgac tt                                                22


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<220>  
<223>  Scrambled Cul4b shRNA

<400>  13
gtcgcagcaa taaatacggc t                                                 21


<210>  14
<211>  19
<212>  DNA
<213>  Homo sapiens

<220>  
<223>  Cul4a shRNA

<400>  14
gaagctggtc atcaagaac                                                    19


<210>  15
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<220>  
<223>  Cul4a truncated up

<400>  15
gcgatatccg cggacgaggg ccctcg                                            26


<210>  16
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<220>  
<223>  Cul4a truncated 1st down

<400>  16
catatagtct ctgtctataa gtgactcaat cctttttttc aaatctccag gctccttaaa       60

gtccgccttc agc                                                          73


<210>  17
<211>  74
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<220>  
<223>  Cul4a truncated 2nd down

<400>  17
gctctagatc atgccacgta gtggtactga tttggactgt ctttgtctcg ttccatatag       60

tctctgtcta taag                                                         74


<210>  18
<211>  295
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  DN-CUL4A (M1-L295)

<400>  18

Met Ala Asp Glu Ala Pro Arg Lys Gly Ser Phe Ser Ala Leu Val Gly 
1               5                   10                  15      


Arg Thr Asn Gly Leu Thr Lys Pro Ala Ala Leu Ala Ala Ala Pro Ala 
            20                  25                  30          


Lys Pro Gly Gly Ala Gly Gly Ser Lys Lys Leu Val Ile Lys Asn Phe 
        35                  40                  45              


Arg Asp Arg Pro Arg Leu Pro Asp Asn Tyr Thr Gln Asp Thr Trp Arg 
    50                  55                  60                  


Lys Leu His Glu Ala Val Arg Ala Val Gln Ser Ser Thr Ser Ile Arg 
65                  70                  75                  80  


Tyr Asn Leu Glu Glu Leu Tyr Gln Ala Val Glu Asn Leu Cys Ser His 
                85                  90                  95      


Lys Val Ser Pro Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp 
            100                 105                 110         


His Val Gln Ala Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser 
        115                 120                 125             


Val Leu Phe Leu Lys Lys Ile Asn Thr Cys Trp Gln Asp His Cys Arg 
    130                 135                 140                 


Gln Met Ile Met Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Thr Tyr 
145                 150                 155                 160 


Val Leu Gln Asn Ser Thr Leu Pro Ser Ile Trp Asp Met Gly Leu Glu 
                165                 170                 175     


Leu Phe Arg Thr His Ile Ile Ser Asp Lys Met Val Gln Ser Lys Thr 
            180                 185                 190         


Ile Asp Gly Ile Leu Leu Leu Ile Glu Arg Glu Arg Ser Gly Glu Ala 
        195                 200                 205             


Val Asp Arg Ser Leu Leu Arg Ser Leu Leu Gly Met Leu Ser Asp Leu 
    210                 215                 220                 


Gln Val Tyr Lys Asp Ser Phe Glu Leu Lys Phe Leu Glu Glu Thr Asn 
225                 230                 235                 240 


Cys Leu Tyr Ala Ala Glu Gly Gln Arg Leu Met Gln Glu Arg Glu Val 
                245                 250                 255     


Pro Glu Tyr Leu Asn His Val Ser Lys Arg Leu Glu Glu Glu Gly Asp 
            260                 265                 270         


Arg Val Ile Thr Tyr Leu Asp His Ser Thr Gln Lys Pro Leu Ile Ala 
        275                 280                 285             


Cys Val Glu Lys Gln Leu Leu 
    290                 295 


