                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       represented by the Secretary of the Department of Health and 
       Human Services, Centers for Disease Control and Prevention
       Kinney, Claire Y.H.
       Beck, Eric T.
       Kinney, Richard M.
 
<120>  ENGINEERED, CHIMERIC WEST NILE/DENGUE VIRUSES

<130>  6395-80785-02

<150>  US 61/049,342
<151>  2008-04-30

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  10996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant West Nile virus/Dengue-2 virus chimera


<220>
<221>  CDS
<222>  (97)..(10362)

<400>  1
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agc tca aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga tcc gcg ggc atg atc att atg ctg att cca aca gtg atg        450
Lys Lys Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val Met           
        105                 110                 115                       

gcg ttc cat tta acc aca cgt aac gga gaa cca cac atg atc gtc agc        498
Ala Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Ser           
    120                 125                 130                           

aga caa gag aaa ggg aaa agt ctt ctg ttt aaa aca gag gat ggc gtg        546
Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val           
135                 140                 145                 150           

aac atg tgt acc ctc atg gcc atg gac ctt ggt gaa ttg tgt gaa gac        594
Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu Asp           
                155                 160                 165               

aca atc acg tac aag tgt ccc ctt ctc agg cag aat gag cca gaa gac        642
Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp           
            170                 175                 180                   

ata gac tgt tgg tgc aac tct acg tcc acg tgg gta act tat ggg acg        690
Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr           
        185                 190                 195                       

tgt acc acc atg gga gaa cat aga aga gaa aaa aga tca gtg gca ctc        738
Cys Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu           
    200                 205                 210                           

gtt cca cat gtg gga atg gga ctg gag aca cga act gaa aca tgg atg        786
Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met           
215                 220                 225                 230           

tca tca gaa ggg gcc tgg aaa cat gtc cag aga att gaa act tgg atc        834
Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile           
                235                 240                 245               

ttg aga cat cca ggc ttc acc atg atg gca gca atc ctg gca tac acc        882
Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr Thr           
            250                 255                 260                   

ata gga acg aca cat ttc caa aga gcc ctg att ttc atc tta ctg aca        930
Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr           
        265                 270                 275                       

gct gtc act cct tca atg aca atg cgt tgc ata gga atg tca aat aga        978
Ala Val Thr Pro Ser Met Thr Met Arg Cys Ile Gly Met Ser Asn Arg           
    280                 285                 290                           

gac ttt gtg gaa ggg gtt tca gga gga agc tgg gtt gac ata gtc tta       1026
Asp Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu           
295                 300                 305                 310           

gaa cat gga agc tgt gtg acg acg atg gca aaa aac aaa cca aca ttg       1074
Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu           
                315                 320                 325               

gat ttt gaa ctg ata aaa aca gaa gcc aaa cag cct gcc acc cta agg       1122
Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg           
            330                 335                 340                   

aag tac tgt ata gag gca aag cta acc aac aca aca aca gaa tct cgc       1170
Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg           
        345                 350                 355                       

tgc cca aca caa ggg gaa ccc agc cta aat gaa gag cag gac aaa agg       1218
Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg           
    360                 365                 370                           

ttc gtc tgc aaa cac tcc atg gta gac aga gga tgg gga aat gga tgt       1266
Phe Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys           
375                 380                 385                 390           

gga cta ttt gga aag gga ggc att gtg acc tgt gct atg ttc aga tgc       1314
Gly Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Arg Cys           
                395                 400                 405               

aaa aag aac atg gaa gga aaa gtt gtg caa cca gaa aac ttg gaa tac       1362
Lys Lys Asn Met Glu Gly Lys Val Val Gln Pro Glu Asn Leu Glu Tyr           
            410                 415                 420                   

acc att gtg ata aca cct cac tca ggg gaa gag cat gca gtc gga aat       1410
Thr Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn           
        425                 430                 435                       

gac aca gga aaa cat ggc aag gaa atc aaa ata aca cca cag agt tcc       1458
Asp Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser           
    440                 445                 450                           

atc aca gaa gca gaa ttg aca ggt tat ggc act gtc aca atg gag tgc       1506
Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys           
455                 460                 465                 470           

tct cca aga acg ggc ctc gac ttc aat gag atg gtg ttg ttg cag atg       1554
Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met           
                475                 480                 485               

gaa aat aaa gct tgg ctg gtg cac agg caa tgg ttc cta gac ctg ccg       1602
Glu Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro           
            490                 495                 500                   

tta cca tgg ttg ccc gga gcg gac aca caa ggg tca aat tgg ata cag       1650
Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln           
        505                 510                 515                       

aaa gag aca ttg gtc act ttc aaa aat ccc cat gcg aag aaa cag gat       1698
Lys Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp           
    520                 525                 530                           

gtt gtt gtt tta gga tcc caa gaa ggg gcc atg cac aca gca ctt aca       1746
Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr           
535                 540                 545                 550           

ggg gcc aca gaa atc caa atg tca tca gga aac tta ctc ttc aca gga       1794
Gly Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly           
                555                 560                 565               

cat ctc aag tgc agg ctg aga atg gac aag cta cag ctc aaa gga atg       1842
His Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met           
            570                 575                 580                   

tca tac tct atg tgc aca gga aag ttt aaa gtt gtg aag gaa ata gca       1890
Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile Ala           
        585                 590                 595                       

gaa aca caa cat gga aca ata gtt atc aga gtg caa tat gaa ggg gac       1938
Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp           
    600                 605                 610                           

ggc tct cca tgc aag atc cct ttt gag ata atg gat ttg gaa aaa aga       1986
Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg           
615                 620                 625                 630           

cat gtc tta ggt cgc ctg att aca gtc aac cca att gtg aca gaa aaa       2034
His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys           
                635                 640                 645               

gat agc cca gtc aac ata gaa gca gaa cct cca ttc gga gac agc tac       2082
Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr           
            650                 655                 660                   

atc atc ata gga gta gag ccg gga caa ctg aag ctc aac tgg ttt aag       2130
Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys           
        665                 670                 675                       

aaa gga agt tct atc ggc caa atg ttt gag aca aca atg agg ggg gcg       2178
Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala           
    680                 685                 690                           

aag aga atg gcc att tta ggt gac aca gcc tgg gat ttt gga tcc ttg       2226
Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu           
695                 700                 705                 710           

gga gga gtg ttt aca tct ata gga aag gct ctc cac caa gtc ttt gga       2274
Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly           
                715                 720                 725               

gca atc tat gga gct gcc ttc agt ggg gtt tca tgg act atg aaa atc       2322
Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile           
            730                 735                 740                   

ctc ata gga gtc att atc aca tgg ata gga atg aat tca cgc agc acc       2370
Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr           
        745                 750                 755                       

tca ctg tct gtg aca cta gta ttg gtg gga att gtg aca ctg tat ttg       2418
Ser Leu Ser Val Thr Leu Val Leu Val Gly Ile Val Thr Leu Tyr Leu           
    760                 765                 770                           

gga gtc atg gtg cag gcc gat tcc gga tgt gcc ata gac atc agc cgg       2466
Gly Val Met Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile Ser Arg           
775                 780                 785                 790           

caa gag ctg aga tgt gga agt gga gtg ttc ata cac aat gat gtg gag       2514
Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val Glu           
                795                 800                 805               

gct tgg atg gac cgg tac aag tat tac cct gaa acg cca caa ggc cta       2562
Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly Leu           
            810                 815                 820                   

gcc aag atc att cag aaa gct cat aag gaa gga gtg tgc ggt cta cga       2610
Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu Arg           
        825                 830                 835                       

tca gtt tcc aga ctg gag cat caa atg tgg gaa gca gtg aag gac gag       2658
Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp Glu           
    840                 845                 850                           

ctg aac act ctt ttg aag gag aat ggt gtg gac ctt agt gtc gtg gtt       2706
Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val Val           
855                 860                 865                 870           

gag aaa cag gag gga atg tac aag tca gca cct aaa cgc ctc acc gcc       2754
Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr Ala           
                875                 880                 885               

acc acg gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag agt att       2802
Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser Ile           
            890                 895                 900                   

tta ttt gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat ggt ccg       2850
Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly Pro           
        905                 910                 915                       

gag acc aag gaa tgt ccg act cag aat cgc gct tgg aat agc tta gaa       2898
Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu Glu           
    920                 925                 930                           

gtg gag gat ttt gga ttt ggt ctc acc agc act cgg atg ttc ctg aag       2946
Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu Lys           
935                 940                 945                 950           

gtc aga gag agc aac aca act gaa tgt gac tcg aag atc att gga acg       2994
Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly Thr           
                955                 960                 965               

gct gtc aag aac aac ttg gcg atc cac agt gac ctg tcc tat tgg att       3042
Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp Ile           
            970                 975                 980                   

gaa agc agg ctc aat gat acg tgg aag ctt gaa agg gca gtt ctg ggt       3090
Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val Leu Gly           
        985                 990                 995                       

gaa gtc  aaa tca tgt acg tgg  cct gag acg cat acc  ttg tgg ggc        3135
Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr His Thr  Leu Trp Gly            
    1000                 1005                 1010                        

gat gga  atc ctt gag agt gac  ttg ata ata cca gtc  aca ctg gcg        3180
Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile Pro Val  Thr Leu Ala            
    1015                 1020                 1025                        

gga cca  cga agc aat cac aat  cgg aga cct ggg tac  aag aca caa        3225
Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro Gly Tyr  Lys Thr Gln            
    1030                 1035                 1040                        

aac cag  ggc cca tgg gac gaa  ggc cgg gta gag att  gac ttc gat        3270
Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val Glu Ile  Asp Phe Asp            
    1045                 1050                 1055                        

tac tgc  cca gga act acg gtc  acc ctg agt gag agc  tgc gga cac        3315
Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser Glu Ser  Cys Gly His            
    1060                 1065                 1070                        

cgt gga  cct gcc act cgc acc  acc aca gag agc gga  aag ttg ata        3360
Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu Ser Gly  Lys Leu Ile            
    1075                 1080                 1085                        

aca gat  tgg tgc tgc agg agc  tgc acc tta cca cca  ctg cgc tac        3405
Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr            
    1090                 1095                 1100                        

caa act  gac agc ggc tgt tgg  tat ggt atg gag atc  aga cca cag        3450
Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Gln            
    1105                 1110                 1115                        

aga cat  gat gaa aag acc ctc  gtg cag tca caa gtg  aat gct tat        3495
Arg His  Asp Glu Lys Thr Leu  Val Gln Ser Gln Val  Asn Ala Tyr            
    1120                 1125                 1130                        

aat gct  gat atg att gac cct  ttt cag ttg ggc ctt  ctg gtc gtg        3540
Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu Gly Leu  Leu Val Val            
    1135                 1140                 1145                        

ttc ttg  gcc acc cag gag gtc  ctt cgc aag agg tgg  aca gcc aag        3585
Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys Arg Trp  Thr Ala Lys            
    1150                 1155                 1160                        

atc agc  atg cca gct ata ctg  att gct ctg cta gtc  ctg gtg ttt        3630
Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu Leu Val  Leu Val Phe            
    1165                 1170                 1175                        

ggg ggc  att act tac act gat  gtg tta cgc tat gtc  atc ttg gtg        3675
Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg Tyr Val  Ile Leu Val            
    1180                 1185                 1190                        

ggg gca  gct ttc gca gaa tct  aat tcg gga gga gac  gtg gta cac        3720
Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly Gly Asp  Val Val His            
    1195                 1200                 1205                        

ttg gcg  ctc atg gcg acc ttc  aag ata caa cca gtg  ttt atg gtg        3765
Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln Pro Val  Phe Met Val            
    1210                 1215                 1220                        

gca tcg  ttt ctc aaa gcg aga  tgg acc aac cag gag  aac att ttg        3810
Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn Gln Glu  Asn Ile Leu            
    1225                 1230                 1235                        

ttg atg  ttg gcg gct gtt ttc  ttt caa atg gct tat  tac gat gcc        3855
Leu Met  Leu Ala Ala Val Phe  Phe Gln Met Ala Tyr  Tyr Asp Ala            
    1240                 1245                 1250                        

cgc caa  att ctg ctc tgg gag  atc cct gat gtg ttg  aat tca ctg        3900
Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp Val Leu  Asn Ser Leu            
    1255                 1260                 1265                        

gcg gta  gct tgg atg ata ctg  aga gcc ata aca ttc  aca acg aca        3945
Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile Thr Phe  Thr Thr Thr            
    1270                 1275                 1280                        

tca aac  gtg gtt gtt ccg ctg  cta gcc ctg cta aca  ccc ggg ctg        3990
Ser Asn  Val Val Val Pro Leu  Leu Ala Leu Leu Thr  Pro Gly Leu            
    1285                 1290                 1295                        

aga tgc  ttg aat ctg gat gtg  tac agg ata ctg ctg  ttg atg gtc        4035
Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile Leu Leu  Leu Met Val            
    1300                 1305                 1310                        

gga ata  ggc agc ttg atc agg  gag aag agg agt gca  gct gca aaa        4080
Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg Ser Ala  Ala Ala Lys            
    1315                 1320                 1325                        

aag aaa  gga gca agt ctg cta  tgc ttg gct cta gcc  tca aca gga        4125
Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala Leu Ala  Ser Thr Gly            
    1330                 1335                 1340                        

ctt ttc  aac ccc atg atc ctt  gct gct gga ctg att  gca tgt gat        4170
Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly Leu Ile  Ala Cys Asp            
    1345                 1350                 1355                        

ccc aac  cgt aaa cgc gga tgg  ccc gca act gaa gtg  atg aca gct        4215
Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr Glu Val  Met Thr Ala            
    1360                 1365                 1370                        

gtc ggc  cta atg ttt gcc atc  gtc gga ggg ctg gca  gag ctt gac        4260
Val Gly  Leu Met Phe Ala Ile  Val Gly Gly Leu Ala  Glu Leu Asp            
    1375                 1380                 1385                        

att gac  tcc atg gcc att cca  atg act atc gcg ggg  ctc atg ttt        4305
Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile Ala Gly  Leu Met Phe            
    1390                 1395                 1400                        

gct gct  ttc gtg att tct ggg  aaa tca aca gat atg  tgg att gag        4350
Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr Asp Met  Trp Ile Glu            
    1405                 1410                 1415                        

aga acg  gcg gac att tcc tgg  gaa agt gat gca gaa  att aca ggc        4395
Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp Ala Glu  Ile Thr Gly            
    1420                 1425                 1430                        

tcg agc  gaa aga gtt gat gtg  cgg ctt gat gat gat  gga aac ttc        4440
Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp Asp Asp  Gly Asn Phe            
    1435                 1440                 1445                        

cag ctc  atg aat gat cca gga  gca cct tgg aag ata  tgg atg ctc        4485
Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp Lys Ile  Trp Met Leu            
    1450                 1455                 1460                        

aga atg  gtc tgt ctc gcg att  agt gcg tac acc ccc  tgg gca atc        4530
Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr Thr Pro  Trp Ala Ile            
    1465                 1470                 1475                        

ttg ccc  tca gta gtt gga ttt  tgg ata act ctc caa  tac aca aag        4575
Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr Leu Gln  Tyr Thr Lys            
    1480                 1485                 1490                        

aga gga  ggc gtg ttg tgg gac  act ccc tca cca aag  gag tac aaa        4620
Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser Pro Lys  Glu Tyr Lys            
    1495                 1500                 1505                        

aag ggg  gac acg acc acc ggc  gtc tac agg atc atg  act cgt ggg        4665
Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg Ile Met  Thr Arg Gly            
    1510                 1515                 1520                        

ctg ctc  ggc agt tat caa gca  gga gcg ggc gtg atg  gtt gaa ggt        4710
Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly Val Met  Val Glu Gly            
    1525                 1530                 1535                        

gtt ttc  cac acc ctt tgg cat  aca aca aaa gga gcc  gct ttg atg        4755
Val Phe  His Thr Leu Trp His  Thr Thr Lys Gly Ala  Ala Leu Met            
    1540                 1545                 1550                        

agc gga  gag ggc cgc ctg gac  cca tac tgg ggc agt  gtc aag gag        4800
Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp Gly Ser  Val Lys Glu            
    1555                 1560                 1565                        

gat cga  ctt tgt tac gga gga  ccc tgg aaa ttg cag  cac aag tgg        4845
Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys Leu Gln  His Lys Trp            
    1570                 1575                 1580                        

aac ggg  cag gat gag gtg cag  atg att gtg gtg gaa  cct ggc agg        4890
Asn Gly  Gln Asp Glu Val Gln  Met Ile Val Val Glu  Pro Gly Arg            
    1585                 1590                 1595                        

aac gtt  aag aac gtc cag acg  aaa cca ggg gtg ttc  aaa aca cct        4935
Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly Val Phe  Lys Thr Pro            
    1600                 1605                 1610                        

gaa gga  gaa atc ggg gcc gtg  act ttg gac ttc ccc  act gga aca        4980
Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp Phe Pro  Thr Gly Thr            
    1615                 1620                 1625                        

tca ggc  tca cca ata gtg gac  aaa aac ggt gat gtg  att ggg ctt        5025
Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly Asp Val  Ile Gly Leu            
    1630                 1635                 1640                        

tat ggc  aat gga gtc ata atg  ccc aac ggc tca tac  ata agc gcg        5070
Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly Ser Tyr  Ile Ser Ala            
    1645                 1650                 1655                        

ata gtg  cag ggt gaa agg atg  gat gag cca atc cca  gcc gga ttc        5115
Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro Ile Pro  Ala Gly Phe            
    1660                 1665                 1670                        

gaa cct  gag atg ctg agg aaa  aaa cag atc act gta  ctg gat ctc        5160
Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile Thr Val  Leu Asp Leu            
    1675                 1680                 1685                        

cat ccc  ggc gcc ggt aaa aca  agg agg att ctg cca  cag atc atc        5205
His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile Leu Pro  Gln Ile Ile            
    1690                 1695                 1700                        

aaa gag  gcc ata aac aga aga  ctg aga aca gcc gtg  cta gca cca        5250
Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr Ala Val  Leu Ala Pro            
    1705                 1710                 1715                        

acc agg  gtt gtg gct gct gag  atg gct gaa gca ctg  aga gga ctg        5295
Thr Arg  Val Val Ala Ala Glu  Met Ala Glu Ala Leu  Arg Gly Leu            
    1720                 1725                 1730                        

ccc atc  cgg tac cag aca tcc  gca gtg ccc aga gaa  cat aat gga        5340
Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro Arg Glu  His Asn Gly            
    1735                 1740                 1745                        

aat gag  att gtt gat gtc atg  tgt cat gct acc ctc  acc cac agg        5385
Asn Glu  Ile Val Asp Val Met  Cys His Ala Thr Leu  Thr His Arg            
    1750                 1755                 1760                        

ctg atg  tct cct cac agg gtg  ccg aac tac aac ctg  ttc gtg atg        5430
Leu Met  Ser Pro His Arg Val  Pro Asn Tyr Asn Leu  Phe Val Met            
    1765                 1770                 1775                        

gat gag  gct cat ttc acc gac  cca gct agc att gca  gca aga ggt        5475
Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly            
    1780                 1785                 1790                        

tac att  tcc aca aag gtc gag  cta ggg gag gcg gcg  gca ata ttc        5520
Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu Ala Ala  Ala Ile Phe            
    1795                 1800                 1805                        

atg aca  gcc acc cca cca ggc  act tca gat cca ttc  cca gag tcc        5565
Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp Pro Phe  Pro Glu Ser            
    1810                 1815                 1820                        

aat tca  cca att tcc gac tta  cag act gag atc ccg  gat cga gct        5610
Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu Ile Pro  Asp Arg Ala            
    1825                 1830                 1835                        

tgg aac  tct gga tac gaa tgg  atc aca gaa tac acc  ggg aag acg        5655
Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu Tyr Thr  Gly Lys Thr            
    1840                 1845                 1850                        

gtt tgg  ttt gtg cct agt gtc  aag atg ggg aat gag  att gcc ctt        5700
Val Trp  Phe Val Pro Ser Val  Lys Met Gly Asn Glu  Ile Ala Leu            
    1855                 1860                 1865                        

tgc cta  caa cgt gct gga aag  aaa gta gtc caa ttg  aac aga aag        5745
Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val Gln Leu  Asn Arg Lys            
    1870                 1875                 1880                        

tcg tac  gag acg gag tac cca  aaa tgt aag aac gat  gat tgg gac        5790
Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys Asn Asp  Asp Trp Asp            
    1885                 1890                 1895                        

ttt gtt  atc aca aca gac ata  tct gaa atg ggg gct  aac ttc aag        5835
Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys            
    1900                 1905                 1910                        

gcg agc  agg gtg att gac agc  cgg aag agt gtg aaa  cca acc atc        5880
Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser Val Lys  Pro Thr Ile            
    1915                 1920                 1925                        

ata aca  gaa gga gaa ggg aga  gtg atc ctg gga gaa  cca tct gca        5925
Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu Gly Glu  Pro Ser Ala            
    1930                 1935                 1940                        

gtg aca  gca gct agt gcc gcc  cag aga cgt gga cgt  atc ggt aga        5970
Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg            
    1945                 1950                 1955                        

aat ccg  tcg caa gtt ggt gat  gag tac tgt tat ggg  ggg cac acg        6015
Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys Tyr Gly  Gly His Thr            
    1960                 1965                 1970                        

aat gaa  gac gac tcg aac ttc  gcc cat tgg act gag  gca cga atc        6060
Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp Thr Glu  Ala Arg Ile            
    1975                 1980                 1985                        

atg ctg  gac aac atc aac atg  cca aac gga ctg atc  gct caa ttc        6105
Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly Leu Ile  Ala Gln Phe            
    1990                 1995                 2000                        

tac caa  cca gag cgt gag aag  gta tat acc atg gat  ggg gaa tac        6150
Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr Met Asp  Gly Glu Tyr            
    2005                 2010                 2015                        

cgg ctc  aga gga gaa gag aga  aaa aac ttt ctg gaa  ctg ttg agg        6195
Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe Leu Glu  Leu Leu Arg            
    2020                 2025                 2030                        

act gca  gat ctg cca gtt tgg  ctg gct tac aag gtt  gca gcg gct        6240
Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr Lys Val  Ala Ala Ala            
    2035                 2040                 2045                        

gga gtg  tca tac cac gac cgg  agg tgg tgc ttt gat  ggt cct agg        6285
Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys Phe Asp  Gly Pro Arg            
    2050                 2055                 2060                        

aca aac  aca att tta gaa gac  aac aac gaa gtg gaa  gtc atc acg        6330
Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu Val Glu  Val Ile Thr            
    2065                 2070                 2075                        

aag ctt  ggt gaa agg aag att  ctg agg ccg cgc tgg  att gac gcc        6375
Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro Arg Trp  Ile Asp Ala            
    2080                 2085                 2090                        

agg gtg  tac tcg gat cac cag  gca cta aag gcg ttc  aag gac ttc        6420
Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys Ala Phe  Lys Asp Phe            
    2095                 2100                 2105                        

gcc tcg  gga aaa cgt tct cag  ata ggg ctc att gag  gtt ctg gga        6465
Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu Ile Glu  Val Leu Gly            
    2110                 2115                 2120                        

aag atg  cct gag cac ttc atg  ggg aag aca tgg gaa  gca ctt gac        6510
Lys Met  Pro Glu His Phe Met  Gly Lys Thr Trp Glu  Ala Leu Asp            
    2125                 2130                 2135                        

acc atg  tac gtt gtg gcc act  gca gag aaa gga gga  aga gct cac        6555
Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys Gly Gly  Arg Ala His            
    2140                 2145                 2150                        

aga atg  gcc ctg gag gaa ctg  cca gat gct ctt cag  aca att gcc        6600
Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala Leu Gln  Thr Ile Ala            
    2155                 2160                 2165                        

ttg att  gcc tta ttg agt gtg  atg acc atg gga gta  ttc ttc ctc        6645
Leu Ile  Ala Leu Leu Ser Val  Met Thr Met Gly Val  Phe Phe Leu            
    2170                 2175                 2180                        

ctc atg  cag cgg aag ggc att  gga aag ata ggt ttg  gga ggc gct        6690
Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile Gly Leu  Gly Gly Ala            
    2185                 2190                 2195                        

gtc ttg  gga gtc gcg acc ttt  ttc tgt tgg atg gct  gaa gtt cca        6735
Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp Met Ala  Glu Val Pro            
    2200                 2205                 2210                        

gga acg  aag atc gcc gga atg  ttg ctg ctc tcc ctt  ctc ttg atg        6780
Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu Ser Leu  Leu Leu Met            
    2215                 2220                 2225                        

att gtg  cta att cct gag cca  gag aag caa cgt tcg  cag aca gac        6825
Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Ser  Gln Thr Asp            
    2230                 2235                 2240                        

aac cag  cta gcc gtg ttc ctg  att tgt gtc atg acc  ctt gtg agc        6870
Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val Met Thr  Leu Val Ser            
    2245                 2250                 2255                        

gca gtg  gca gcc aac gag atg  ggt tgg cta gat aag  acc aag agt        6915
Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu Asp Lys  Thr Lys Ser            
    2260                 2265                 2270                        

gac ata  agc agt ttg ttt ggg  caa aga att gag gtc  aag gag aat        6960
Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile Glu Val  Lys Glu Asn            
    2275                 2280                 2285                        

ttc agc  atg gga gag ttt ctt  ttg gac ttg agg cct  gca aca gcc        7005
Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu Arg Pro  Ala Thr Ala            
    2290                 2295                 2300                        

tgg tca  ctg tac gct gtg aca  aca gcg gtc ctc act  cca ctg cta        7050
Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val Leu Thr  Pro Leu Leu            
    2305                 2310                 2315                        

aag cat  ttg atc acg tca gat  tac atc aac acc tca  ttg acc tca        7095
Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn Thr Ser  Leu Thr Ser            
    2320                 2325                 2330                        

ata aac  gtt cag gca agt gca  cta ttc aca ctc gcg  cga ggc ttc        7140
Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr Leu Ala  Arg Gly Phe            
    2335                 2340                 2345                        

ccc ttc  gtc gat gtt gga gtg  tcg gct ctc ctg cta  gca gcc gga        7185
Pro Phe  Val Asp Val Gly Val  Ser Ala Leu Leu Leu  Ala Ala Gly            
    2350                 2355                 2360                        

tgc tgg  gga caa gtc acc ctc  acc gtt acg gta aca  gcg gca aca        7230
Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr Val Thr  Ala Ala Thr            
    2365                 2370                 2375                        

ctc ctt  ttt tgc cac tat gcc  tac atg gtt ccc ggt  tgg caa gct        7275
Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val Pro Gly  Trp Gln Ala            
    2380                 2385                 2390                        

gag gca  atg cgc tca gcc cag  cgg cgg aca gcg gcc  gga atc atg        7320
Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr Ala Ala  Gly Ile Met            
    2395                 2400                 2405                        

aag aac  gct gta gtg gat ggc  atc gtg gcc acg gac  gtc cca gaa        7365
Lys Asn  Ala Val Val Asp Gly  Ile Val Ala Thr Asp  Val Pro Glu            
    2410                 2415                 2420                        

tta gag  cgc acc aca ccc atc  atg cag aag aaa gtt  gga cag atc        7410
Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys Lys Val  Gly Gln Ile            
    2425                 2430                 2435                        

atg ctg  atc ttg gtg tct cta  gct gca gta gta gtg  aac ccg tct        7455
Met Leu  Ile Leu Val Ser Leu  Ala Ala Val Val Val  Asn Pro Ser            
    2440                 2445                 2450                        

gtg aag  aca gta cga gaa gcc  gga att ttg atc acg  gcc gca gcg        7500
Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu Ile Thr  Ala Ala Ala            
    2455                 2460                 2465                        

gtg acg  ctt tgg gag aat gga  gca agc tct gtt tgg  aac gca aca        7545
Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser Val Trp  Asn Ala Thr            
    2470                 2475                 2480                        

act gcc  atc gga ctc tgc cac  atc atg cgt ggg ggt  tgg ttg tca        7590
Thr Ala  Ile Gly Leu Cys His  Ile Met Arg Gly Gly  Trp Leu Ser            
    2485                 2490                 2495                        

tgt cta  tcc ata aca tgg aca  ctc ata aag aac atg  gaa aaa cca        7635
Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys Asn Met  Glu Lys Pro            
    2500                 2505                 2510                        

gga cta  aaa aga ggt ggg gca  aaa gga cgc acc ttg  gga gag gtt        7680
Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg Thr Leu  Gly Glu Val            
    2515                 2520                 2525                        

tgg aaa  gaa aga ctc aac cag  atg aca aaa gaa gag  ttc act agg        7725
Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys Glu Glu  Phe Thr Arg            
    2530                 2535                 2540                        

tac cgc  aaa gag gcc atc atc  gaa gtc gat cgc tca  gcg gca aaa        7770
Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp Arg Ser  Ala Ala Lys            
    2545                 2550                 2555                        

cac gcc  agg aaa gaa ggc aat  gtc act gga ggg cat  cca gtc tct        7815
His Ala  Arg Lys Glu Gly Asn  Val Thr Gly Gly His  Pro Val Ser            
    2560                 2565                 2570                        

agg ggc  aca gca aaa ctg aga  tgg ctg gtc gaa cgg  agg ttt ctc        7860
Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val Glu Arg  Arg Phe Leu            
    2575                 2580                 2585                        

gaa ccg  gtc gga aaa gtg att  gac ctt gga tgt gga  aga ggc ggt        7905
Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly Cys Gly  Arg Gly Gly            
    2590                 2595                 2600                        

tgg tgt  tac tat atg gca acc  caa aaa aga gtc caa  gaa gtc aga        7950
Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg Val Gln  Glu Val Arg            
    2605                 2610                 2615                        

ggg tac  aca aag ggc ggt ccc  gga cat gaa gag ccc  caa cta gtg        7995
Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu Glu Pro  Gln Leu Val            
    2620                 2625                 2630                        

caa agt  tat gga tgg aac att  gtc acc atg aag agt  gga gtg gat        8040
Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met Lys Ser  Gly Val Asp            
    2635                 2640                 2645                        

gtg ttc  tac aga cct tct gag  tgt tgt gac acc ctc  ctt tgt gac        8085
Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp Thr Leu  Leu Cys Asp            
    2650                 2655                 2660                        

atc gga  gag tcc tcg tca agt  gct gag gtt gaa gag  cat agg acg        8130
Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val Glu Glu  His Arg Thr            
    2665                 2670                 2675                        

att cgg  gtc ctt gaa atg gtt  gag gac tgg ctg cac  cga ggg cca        8175
Ile Arg  Val Leu Glu Met Val  Glu Asp Trp Leu His  Arg Gly Pro            
    2680                 2685                 2690                        

agg gaa  ttt tgc gtg aag gtg  ctc tgc ccc tac atg  ccg aaa gtc        8220
Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro Tyr Met  Pro Lys Val            
    2695                 2700                 2705                        

ata gag  aag atg gag ctg ctc  caa cgc cgg tat ggg  ggg gga ctg        8265
Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg Tyr Gly  Gly Gly Leu            
    2710                 2715                 2720                        

gtc aga  aac cca ctc tca cgg  aat tcc acg cac gag  atg tat tgg        8310
Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr His Glu  Met Tyr Trp            
    2725                 2730                 2735                        

gtg agt  cga gct tca ggc aat  gtg gta cat tca gtg  aat atg acc        8355
Val Ser  Arg Ala Ser Gly Asn  Val Val His Ser Val  Asn Met Thr            
    2740                 2745                 2750                        

agc cag  gtg ctc cta gga aga  atg gaa aaa agg acc  tgg aag gga        8400
Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys Arg Thr  Trp Lys Gly            
    2755                 2760                 2765                        

ccc caa  tac gag gaa gat gta  aac ttg gga agt gga  acc agg gcg        8445
Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly Ser Gly  Thr Arg Ala            
    2770                 2775                 2780                        

gtg gga  aaa ccc ctg ctc aac  tca gac acc agt aaa  atc aag aac        8490
Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr Ser Lys  Ile Lys Asn            
    2785                 2790                 2795                        

agg att  gaa cga ctc agg cgt  gag tac agt tcg acg  tgg cac cac        8535
Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser Ser Thr  Trp His His            
    2800                 2805                 2810                        

gat gag  aac cac cca tat aga  acc tgg aac tat cac  ggc agt tat        8580
Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn Tyr His  Gly Ser Tyr            
    2815                 2820                 2825                        

gat gtg  aag ccc aca ggc tcc  gcc agt tcg ctg gtc  aat gga gtg        8625
Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser Leu Val  Asn Gly Val            
    2830                 2835                 2840                        

gtc agg  ctc ctc tca aaa cca  tgg gac acc atc acg  aat gtt acc        8670
Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr Ile Thr  Asn Val Thr            
    2845                 2850                 2855                        

acc atg  gcc atg act gac act  act ccc ttc ggg cag  cag cga gtg        8715
Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe Gly Gln  Gln Arg Val            
    2860                 2865                 2870                        

ttc aaa  gag aag gtg gac acg  aaa gct cct gaa ccg  cca gaa gga        8760
Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro Glu Pro  Pro Glu Gly            
    2875                 2880                 2885                        

gtg aag  tac gtg ctc aac gag  acc acc aac tgg ttg  tgg gcg ttt        8805
Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn Trp Leu  Trp Ala Phe            
    2890                 2895                 2900                        

ttg gcc  aga gaa aaa cgt ccc  aga atg tgc tct cga  gag gaa ttc        8850
Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys Ser Arg  Glu Glu Phe            
    2905                 2910                 2915                        

ata aga  aag gtc aac agc aat  gca gct ttg ggt gcc  atg ttt gaa        8895
Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu Gly Ala  Met Phe Glu            
    2920                 2925                 2930                        

gag cag  aat caa tgg agg agc  gcc aga gaa gca gtt  gaa gat cca        8940
Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu Ala Val  Glu Asp Pro            
    2935                 2940                 2945                        

aaa ttt  tgg gag atg gtg gat  gag gag cgc gag gca  cat ctg cgg        8985
Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg Glu Ala  His Leu Arg            
    2950                 2955                 2960                        

ggg gaa  tgt cac act tgc att  tac aac atg atg gga  aag aga gag        9030
Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met Met Gly  Lys Arg Glu            
    2965                 2970                 2975                        

aaa aaa  ccc gga gag ttc gga  aag gcc aag gga agc  aga gcc att        9075
Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys Gly Ser  Arg Ala Ile            
    2980                 2985                 2990                        

tgg ttc  atg tgg ctc gga gct  cgc ttt ctg gag ttc  gag gct ctg        9120
Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu Glu Phe  Glu Ala Leu            
    2995                 3000                 3005                        

ggt ttt  ctc aat gaa gac cac  tgg ctt gga aga aag  aac tca gga        9165
Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly Arg Lys  Asn Ser Gly            
    3010                 3015                 3020                        

gga ggt  gtc gag ggc ttg ggc  ctc caa aaa ctg ggt  tac atc ctg        9210
Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys Leu Gly  Tyr Ile Leu            
    3025                 3030                 3035                        

cgt gaa  gtt ggc acc cgg cct  ggg ggc aag atc tat  gct gat gac        9255
Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys Ile Tyr  Ala Asp Asp            
    3040                 3045                 3050                        

aca gct  ggc tgg gac acc cgc  atc acg aga gct gac  ttg gaa aat        9300
Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg Ala Asp  Leu Glu Asn            
    3055                 3060                 3065                        

gaa gct  aag gtg ctt gag ctg  ctt gat ggg gaa cat  cgg cgt ctt        9345
Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly Glu His  Arg Arg Leu            
    3070                 3075                 3080                        

gcc agg  gcc atc att gag ctc  acc tat cgt cac aaa  gtt gtg aaa        9390
Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg His Lys  Val Val Lys            
    3085                 3090                 3095                        

gtg atg  cgc ccg gct gct gat  gga aga acc gtc atg  gat gtt atc        9435
Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr Val Met  Asp Val Ile            
    3100                 3105                 3110                        

tcc aga  gaa gat cag agg ggg  agt gga caa gtt gtc  acc tac gcc        9480
Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln Val Val  Thr Tyr Ala            
    3115                 3120                 3125                        

cta aac  act ttc acc aac ctg  gcc gtc cag ctg gtg  agg atg atg        9525
Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln Leu Val  Arg Met Met            
    3130                 3135                 3140                        

gaa ggg  gaa gga gtg att ggc  cca gat gat gtg gag  aaa ctc aca        9570
Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp Val Glu  Lys Leu Thr            
    3145                 3150                 3155                        

aaa ggg  aaa gga ccc aaa gtc  agg acc tgg ctg ttt  gag aat ggg        9615
Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp Leu Phe  Glu Asn Gly            
    3160                 3165                 3170                        

gaa gaa  aga ctc agc cgc atg  gct gtc agt gga gat  gac tgt gtg        9660
Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser Gly Asp  Asp Cys Val            
    3175                 3180                 3185                        

gta aag  ccc ctg gac gat cgc  ttt gcc acc tcg ctc  cac ttc ctc        9705
Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr Ser Leu  His Phe Leu            
    3190                 3195                 3200                        

aat gct  atg tca aag gtt cgc  aaa gac atc caa gag  tgg aaa ccg        9750
Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile Gln Glu  Trp Lys Pro            
    3205                 3210                 3215                        

tca act  gga tgg tat gat tgg  cag cag gtt cca ttt  tgc tca aac        9795
Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val Pro Phe  Cys Ser Asn            
    3220                 3225                 3230                        

cat ttc  act gaa ttg atc atg  aaa gat gga aga aca  ctg gtg gtt        9840
His Phe  Thr Glu Leu Ile Met  Lys Asp Gly Arg Thr  Leu Val Val            
    3235                 3240                 3245                        

cca tgc  cga gga cag gat gaa  ttg gta ggc aga gct  cgc ata tct        9885
Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly Arg Ala  Arg Ile Ser            
    3250                 3255                 3260                        

cca ggg  gcc gga tgg aac gtc  cgc gac act gct tgt  ctg gct aag        9930
Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr Ala Cys  Leu Ala Lys            
    3265                 3270                 3275                        

tct tat  gcc cag atg tgg ctg  ctt ctg tac ttc cac  aga aga gac        9975
Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr Phe His  Arg Arg Asp            
    3280                 3285                 3290                        

ctg cgg  ctc atg gcc aac gcc  att tgc tcc gct gtc  cct gtg aat       10020
Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser Ala Val  Pro Val Asn            
    3295                 3300                 3305                        

tgg gtc  cct acc gga aga acc  acg tgg tcc atc cat  gca gga gga       10065
Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser Ile His  Ala Gly Gly            
    3310                 3315                 3320                        

gag tgg  atg aca aca gag gac  atg ttg gag gtc tgg  aac cgt gtt       10110
Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu Val Trp  Asn Arg Val            
    3325                 3330                 3335                        

tgg ata  gag gag aat gaa tgg  atg gaa gac aaa acc  cca gtg gag       10155
Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp Lys Thr  Pro Val Glu            
    3340                 3345                 3350                        

aaa tgg  agt gac gtc cca tat  tca gga aaa cga gag  gac atc tgg       10200
Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys Arg Glu  Asp Ile Trp            
    3355                 3360                 3365                        

tgt ggc  agc ctg att ggc aca  aga gcc cga gcc acg  tgg gca gaa       10245
Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg Ala Thr  Trp Ala Glu            
    3370                 3375                 3380                        

aac atc  cag gtg gct atc aac  caa gtc aga gca atc  atc gga gat       10290
Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg Ala Ile  Ile Gly Asp            
    3385                 3390                 3395                        

gag aag  tat gtg gat tac atg  agt tca cta aag aga  tat gaa gac       10335
Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu Lys Arg  Tyr Glu Asp            
    3400                 3405                 3410                        

aca act  ttg gtt gag gac aca  gta ctg tagatattta atcaattgta          10382
Thr Thr  Leu Val Glu Asp Thr  Val Leu                                     
    3415                 3420                                             

aatagacaat ataagtatgc ataaaagtgt agttttatag tagtatttag tggtgttagt    10442

gtaaatagtt aagaaaattt tgaggagaaa gtcaggccgg gaagttcccg ccaccggaag    10502

ttgagtagac ggtgctgcct gcgactcaac cccaggagga ctgggtgaac aaagccgcga    10562

agtgatccat gtaagccctc agaaccgtct cggaaggagg accccacatg ttgtaacttc    10622

aaagcccaat gtcagaccac gctacggcgt gctactctgc ggagagtgca gtctgcgata    10682

gtgccccagg aggactgggt taacaaaggc aaaccaacgc cccacgcggc cctagccccg    10742

gtaatggtgt taaccagggc gaaaggacta gaggttagag gagaccccgc ggtttaaagt    10802

gcacggccca gcctggctga agctgtaggt caggggaagg actagaggtt agtggagacc    10862

ccgtgccaca aaacaccaca acaaaacagc atattgacac ctgggataga ctaggagatc    10922

ttctgctctg cacaaccagc cacacggcac agtgcgccga caatggtggc tggtggtgcg    10982

agaacacagg atct                                                      10996


<210>  2
<211>  3422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Ser Ala Gly Met Ile Ile Met 
            100                 105                 110         


Leu Ile Pro Thr Val Met Ala Phe His Leu Thr Thr Arg Asn Gly Glu 
        115                 120                 125             


Pro His Met Ile Val Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe 
    130                 135                 140                 


Lys Thr Glu Asp Gly Val Asn Met Cys Thr Leu Met Ala Met Asp Leu 
145                 150                 155                 160 


Gly Glu Leu Cys Glu Asp Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg 
                165                 170                 175     


Gln Asn Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr 
            180                 185                 190         


Trp Val Thr Tyr Gly Thr Cys Thr Thr Met Gly Glu His Arg Arg Glu 
        195                 200                 205             


Lys Arg Ser Val Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr 
    210                 215                 220                 


Arg Thr Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln 
225                 230                 235                 240 


Arg Ile Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Met Met Ala 
                245                 250                 255     


Ala Ile Leu Ala Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu 
            260                 265                 270         


Ile Phe Ile Leu Leu Thr Ala Val Thr Pro Ser Met Thr Met Arg Cys 
        275                 280                 285             


Ile Gly Met Ser Asn Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ser 
    290                 295                 300                 


Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr Thr Met Ala 
305                 310                 315                 320 


Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys 
                325                 330                 335     


Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn 
            340                 345                 350         


Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn 
        355                 360                 365             


Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met Val Asp Arg 
    370                 375                 380                 


Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly Ile Val Thr 
385                 390                 395                 400 


Cys Ala Met Phe Arg Cys Lys Lys Asn Met Glu Gly Lys Val Val Gln 
                405                 410                 415     


Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His Ser Gly Glu 
            420                 425                 430         


Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys Glu Ile Lys 
        435                 440                 445             


Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly 
    450                 455                 460                 


Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu 
465                 470                 475                 480 


Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val His Arg Gln 
                485                 490                 495     


Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln 
            500                 505                 510         


Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe Lys Asn Pro 
        515                 520                 525             


His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln Glu Gly Ala 
    530                 535                 540                 


Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met Ser Ser Gly 
545                 550                 555                 560 


Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg Met Asp Lys 
                565                 570                 575     


Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys 
            580                 585                 590         


Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg 
        595                 600                 605             


Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile 
    610                 615                 620                 


Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile Thr Val Asn 
625                 630                 635                 640 


Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu Ala Glu Pro 
                645                 650                 655     


Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro Gly Gln Leu 
            660                 665                 670         


Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln Met Phe Glu 
        675                 680                 685             


Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly Asp Thr Ala 
    690                 695                 700                 


Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile Gly Lys Ala 
705                 710                 715                 720 


Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val 
                725                 730                 735     


Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr Trp Ile Gly 
            740                 745                 750         


Met Asn Ser Arg Ser Thr Ser Leu Ser Val Thr Leu Val Leu Val Gly 
        755                 760                 765             


Ile Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys 
    770                 775                 780                 


Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe 
785                 790                 795                 800 


Ile His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro 
                805                 810                 815     


Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu 
            820                 825                 830         


Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp 
        835                 840                 845             


Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val 
    850                 855                 860                 


Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala 
865                 870                 875                 880 


Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys 
                885                 890                 895     


Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr 
            900                 905                 910         


Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg 
        915                 920                 925             


Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser 
    930                 935                 940                 


Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp 
945                 950                 955                 960 


Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser 
                965                 970                 975     


Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu 
            980                 985                 990         


Glu Arg Ala Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
        995                 1000                 1005             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1010                 1015                 1020             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1025                 1030                 1035             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1040                 1045                 1050             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1070                 1075                 1080             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1085                 1090                 1095             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1100                 1105                 1110             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1115                 1120                 1125             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1130                 1135                 1140             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1145                 1150                 1155             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1160                 1165                 1170             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1175                 1180                 1185             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1190                 1195                 1200             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1205                 1210                 1215             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1220                 1225                 1230             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1235                 1240                 1245             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1250                 1255                 1260             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1265                 1270                 1275             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1280                 1285                 1290             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1295                 1300                 1305             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1310                 1315                 1320             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1325                 1330                 1335             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1340                 1345                 1350             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1355                 1360                 1365             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1370                 1375                 1380             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1385                 1390                 1395             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1400                 1405                 1410             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1415                 1420                 1425             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1430                 1435                 1440             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1445                 1450                 1455             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1460                 1465                 1470             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1475                 1480                 1485             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1490                 1495                 1500             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1505                 1510                 1515             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1520                 1525                 1530             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1535                 1540                 1545             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1550                 1555                 1560             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1565                 1570                 1575             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1580                 1585                 1590             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1595                 1600                 1605             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1610                 1615                 1620             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1625                 1630                 1635             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1640                 1645                 1650             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1655                 1660                 1665             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1670                 1675                 1680             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1685                 1690                 1695             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1700                 1705                 1710             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1715                 1720                 1725             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1730                 1735                 1740             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1745                 1750                 1755             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1760                 1765                 1770             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1775                 1780                 1785             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1790                 1795                 1800             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1805                 1810                 1815             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1820                 1825                 1830             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1835                 1840                 1845             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1850                 1855                 1860             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1865                 1870                 1875             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1880                 1885                 1890             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1895                 1900                 1905             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1910                 1915                 1920             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1925                 1930                 1935             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1940                 1945                 1950             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1955                 1960                 1965             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1970                 1975                 1980             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    1985                 1990                 1995             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2000                 2005                 2010             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2015                 2020                 2025             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2030                 2035                 2040             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2045                 2050                 2055             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2060                 2065                 2070             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2075                 2080                 2085             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2090                 2095                 2100             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2105                 2110                 2115             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2120                 2125                 2130             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2135                 2140                 2145             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2150                 2155                 2160             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2165                 2170                 2175             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2180                 2185                 2190             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2195                 2200                 2205             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2210                 2215                 2220             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2225                 2230                 2235             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2240                 2245                 2250             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2255                 2260                 2265             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2270                 2275                 2280             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2285                 2290                 2295             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2300                 2305                 2310             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2315                 2320                 2325             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2330                 2335                 2340             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2345                 2350                 2355             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2360                 2365                 2370             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2375                 2380                 2385             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2390                 2395                 2400             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2405                 2410                 2415             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2420                 2425                 2430             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2435                 2440                 2445             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2465                 2470                 2475             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2480                 2485                 2490             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2495                 2500                 2505             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2510                 2515                 2520             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2525                 2530                 2535             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2540                 2545                 2550             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2555                 2560                 2565             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2570                 2575                 2580             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2585                 2590                 2595             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2600                 2605                 2610             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2615                 2620                 2625             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2630                 2635                 2640             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2645                 2650                 2655             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2660                 2665                 2670             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2675                 2680                 2685             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2690                 2695                 2700             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2705                 2710                 2715             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2720                 2725                 2730             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2735                 2740                 2745             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2750                 2755                 2760             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2765                 2770                 2775             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2780                 2785                 2790             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2795                 2800                 2805             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2810                 2815                 2820             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2825                 2830                 2835             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2840                 2845                 2850             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2855                 2860                 2865             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2870                 2875                 2880             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2885                 2890                 2895             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2900                 2905                 2910             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2915                 2920                 2925             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2930                 2935                 2940             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2945                 2950                 2955             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2960                 2965                 2970             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2975                 2980                 2985             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    2990                 2995                 3000             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3005                 3010                 3015             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3020                 3025                 3030             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3035                 3040                 3045             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3050                 3055                 3060             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3065                 3070                 3075             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3080                 3085                 3090             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3095                 3100                 3105             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3110                 3115                 3120             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3125                 3130                 3135             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3140                 3145                 3150             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3155                 3160                 3165             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3185                 3190                 3195             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3230                 3235                 3240             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3245                 3250                 3255             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3365                 3370                 3375             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3380                 3385                 3390             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3395                 3400                 3405             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3410                 3415                 3420         


<210>  3
<211>  10996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant West Nile virus/Dengue-1 virus chimera


<220>
<221>  CDS
<222>  (97)..(10362)

<400>  3
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agc tca aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga tcc gtg acc atg ctc ctt atg ctg ctg ccc aca gcc ctg        450
Lys Lys Arg Ser Val Thr Met Leu Leu Met Leu Leu Pro Thr Ala Leu           
        105                 110                 115                       

gcg ttc cat ctg acg aca cga ggg gga gag ccg cat atg ata gtt agc        498
Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val Ser           
    120                 125                 130                           

aag cag gaa aga gga aag tca ctt ttg ttc aag acc tct gca ggt gtc        546
Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly Val           
135                 140                 145                 150           

aac atg tgc acc ctc att gcg atg gat ttg gga gag ttg tgt gag gac        594
Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu Asp           
                155                 160                 165               

acg atg acc tac aaa tgc ccc cgg atc act gag gcg gaa cca gat gac        642
Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala Glu Pro Asp Asp           
            170                 175                 180                   

gtt gac tgt tgg tgc aat gcc acg gac aca tgg gtg acc tat gga acg        690
Val Asp Cys Trp Cys Asn Ala Thr Asp Thr Trp Val Thr Tyr Gly Thr           
        185                 190                 195                       

tgc tct caa act ggc gaa cac cga cga gac aaa cgt tcc gtc gca ttg        738
Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala Leu           
    200                 205                 210                           

gcc cca cac gtg ggg ctt ggc cta gaa aca aga gcc gaa acg tgg atg        786
Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Ala Glu Thr Trp Met           
215                 220                 225                 230           

tcc tct gaa ggt gct tgg aaa cag ata caa aaa gta gag act tgg gct        834
Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp Ala           
                235                 240                 245               

ctg aga cat cca gga ttc acg gtg ata gcc ctt ttt cta gca cat gcc        882
Leu Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala His Ala           
            250                 255                 260                   

ata gga aca tcc atc acc cag aaa ggg atc att ttc att ttg ctg atg        930
Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu Met           
        265                 270                 275                       

ctg gta aca cca tct atg gcc atg cga tgc gtg gga ata ggc aac aga        978
Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly Asn Arg           
    280                 285                 290                           

gac ttc gtg gaa gga ctg tca gga gca aca tgg gtg gat gtg gta ctg       1026
Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val Leu           
295                 300                 305                 310           

gag cat gga agt tgc gtc acc acc atg gca aaa aac aaa cca aca ctg       1074
Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu           
                315                 320                 325               

gac att gaa ctc ttg aag acg gag gtc aca aac cct gca gtt ctg cgt       1122
Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu Arg           
            330                 335                 340                   

aaa ttg tgc att gaa gct aaa ata tca aac acc acc acc gat tcg aga       1170
Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg           
        345                 350                 355                       

tgt cca aca caa gga gaa gcc aca ctg gtg gaa gaa caa gac gcg aac       1218
Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Ala Asn           
    360                 365                 370                           

ttt gtg tgc cga cga acg ttc gtg gac aga ggc tgg ggc aat ggc tgt       1266
Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly Cys           
375                 380                 385                 390           

ggg cta ttc gga aaa ggt agt cta ata acg tgt gcc aag ttt aag tgt       1314
Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys           
                395                 400                 405               

gtg aca aaa cta gaa gga aag ata gtt caa tat gaa aac cta aaa tat       1362
Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys Tyr           
            410                 415                 420                   

tca gtg ata gtc acc gtc cac act gga gat cag cac cag gtg gga aat       1410
Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val Gly Asn           
        425                 430                 435                       

gag act aca gaa cat gga aca act gca acc ata aca cct caa gct cct       1458
Glu Thr Thr Glu His Gly Thr Thr Ala Thr Ile Thr Pro Gln Ala Pro           
    440                 445                 450                           

acg tcg gaa ata cag ctg acc gac tac gga acc ctt aca tta gat tgt       1506
Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Thr Leu Thr Leu Asp Cys           
455                 460                 465                 470           

tca cct agg aca ggg cta gat ttt aac gag atg gtg ttg ctg aca atg       1554
Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Thr Met           
                475                 480                 485               

aaa gaa aga tca tgg ctt gtc cac aaa caa tgg ttt cca gac tta cca       1602
Lys Glu Arg Ser Trp Leu Val His Lys Gln Trp Phe Pro Asp Leu Pro           
            490                 495                 500                   

ctg cct tgg acc tct ggg gct tca aca tcc caa gag act tgg aac aga       1650
Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn Arg           
        505                 510                 515                       

caa gat tta ctg gtc aca ttt aag aca gct cat gca aag aag cag gaa       1698
Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln Glu           
    520                 525                 530                           

gta gtc gta cta gga tca caa gaa gga gca atg cac act gcg ctg act       1746
Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr           
535                 540                 545                 550           

gga gcg aca gaa atc caa acg tca gga acg aca aca att ttc gca gga       1794
Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe Ala Gly           
                555                 560                 565               

cac cta aaa tgc aga cta aaa atg gac aaa cta act tta aaa ggg atg       1842
His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys Gly Met           
            570                 575                 580                   

tca tat gtg atg tgc aca ggc tca ttc aag tta gag aaa gaa gtg gct       1890
Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val Ala           
        585                 590                 595                       

gag acc cag cat gga act gtt ctg gtg cag gtt aaa tat gaa gga aca       1938
Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly Thr           
    600                 605                 610                           

gac gca cca tgc aag att ccc ttt tcg acc caa gat gag aaa gga gca       1986
Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys Gly Ala           
615                 620                 625                 630           

acc cag aat ggg aga tta ata aca gcc aac ccc ata gtc act gac aaa       2034
Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp Lys           
                635                 640                 645               

gaa aaa cca gtc aat att gag gca gaa cca ccc ttt ggt gag agc tac       2082
Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Tyr           
            650                 655                 660                   

atc gtg gta gga gca ggt gaa aaa gct ttg aaa cta agc tgg ttc aag       2130
Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe Lys           
        665                 670                 675                       

aaa gga agc agc ata ggg aaa atg ttt gaa gca act gcc cga gga gca       2178
Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala           
    680                 685                 690                           

cga agg atg gcc att ctg gga gac acc gca tgg gac ttc ggt tct ata       2226
Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile           
695                 700                 705                 710           

gga gga gtg ttc acg tct atg gga aaa ctg gta cac cag gtt ttt gga       2274
Gly Gly Val Phe Thr Ser Met Gly Lys Leu Val His Gln Val Phe Gly           
                715                 720                 725               

act gca tat gga gtt ttg ttt agc gga gtt tct tgg acc atg aaa ata       2322
Thr Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys Ile           
            730                 735                 740                   

gga ata ggg att ctg ctg aca tgg cta gga tta aat tca agg aac acg       2370
Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Asn Thr           
        745                 750                 755                       

tcc ctt tcg atg atg tgc atc gca gtt ggc atg gtc aca ctg tac cta       2418
Ser Leu Ser Met Met Cys Ile Ala Val Gly Met Val Thr Leu Tyr Leu           
    760                 765                 770                           

gga gtc atg gtt cag gca gat tcc gga tgt gcc ata gac atc agc cgg       2466
Gly Val Met Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile Ser Arg           
775                 780                 785                 790           

caa gag ctg aga tgt gga agt gga gtg ttc ata cac aat gat gtg gag       2514
Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val Glu           
                795                 800                 805               

gct tgg atg gac cgg tac aag tat tac cct gaa acg cca caa ggc cta       2562
Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly Leu           
            810                 815                 820                   

gcc aag atc att cag aaa gct cat aag gaa gga gtg tgc ggt cta cga       2610
Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu Arg           
        825                 830                 835                       

tca gtt tcc aga ctg gag cat caa atg tgg gaa gca gtg aag gac gag       2658
Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp Glu           
    840                 845                 850                           

ctg aac act ctt ttg aag gag aat ggt gtg gac ctt agt gtc gtg gtt       2706
Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val Val           
855                 860                 865                 870           

gag aaa cag gag gga atg tac aag tca gca cct aaa cgc ctc acc gcc       2754
Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr Ala           
                875                 880                 885               

acc acg gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag agt att       2802
Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser Ile           
            890                 895                 900                   

tta ttt gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat ggt ccg       2850
Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly Pro           
        905                 910                 915                       

gag acc aag gaa tgt ccg act cag aat cgc gct tgg aat agc tta gaa       2898
Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu Glu           
    920                 925                 930                           

gtg gag gat ttt gga ttt ggt ctc acc agc act cgg atg ttc ctg aag       2946
Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu Lys           
935                 940                 945                 950           

gtc aga gag agc aac aca act gaa tgt gac tcg aag atc att gga acg       2994
Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly Thr           
                955                 960                 965               

gct gtc aag aac aac ttg gcg atc cac agt gac ctg tcc tat tgg att       3042
Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp Ile           
            970                 975                 980                   

gaa agc agg ctc aat gat acg tgg aag ctt gaa agg gca gtt ctg ggt       3090
Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val Leu Gly           
        985                 990                 995                       

gaa gtc  aaa tca tgt acg tgg  cct gag acg cat acc  ttg tgg ggc        3135
Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr His Thr  Leu Trp Gly            
    1000                 1005                 1010                        

gat gga  atc ctt gag agt gac  ttg ata ata cca gtc  aca ctg gcg        3180
Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile Pro Val  Thr Leu Ala            
    1015                 1020                 1025                        

gga cca  cga agc aat cac aat  cgg aga cct ggg tac  aag aca caa        3225
Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro Gly Tyr  Lys Thr Gln            
    1030                 1035                 1040                        

aac cag  ggc cca tgg gac gaa  ggc cgg gta gag att  gac ttc gat        3270
Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val Glu Ile  Asp Phe Asp            
    1045                 1050                 1055                        

tac tgc  cca gga act acg gtc  acc ctg agt gag agc  tgc gga cac        3315
Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser Glu Ser  Cys Gly His            
    1060                 1065                 1070                        

cgt gga  cct gcc act cgc acc  acc aca gag agc gga  aag ttg ata        3360
Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu Ser Gly  Lys Leu Ile            
    1075                 1080                 1085                        

aca gat  tgg tgc tgc agg agc  tgc acc tta cca cca  ctg cgc tac        3405
Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr            
    1090                 1095                 1100                        

caa act  gac agc ggc tgt tgg  tat ggt atg gag atc  aga cca cag        3450
Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Gln            
    1105                 1110                 1115                        

aga cat  gat gaa aag acc ctc  gtg cag tca caa gtg  aat gct tat        3495
Arg His  Asp Glu Lys Thr Leu  Val Gln Ser Gln Val  Asn Ala Tyr            
    1120                 1125                 1130                        

aat gct  gat atg att gac cct  ttt cag ttg ggc ctt  ctg gtc gtg        3540
Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu Gly Leu  Leu Val Val            
    1135                 1140                 1145                        

ttc ttg  gcc acc cag gag gtc  ctt cgc aag agg tgg  aca gcc aag        3585
Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys Arg Trp  Thr Ala Lys            
    1150                 1155                 1160                        

atc agc  atg cca gct ata ctg  att gct ctg cta gtc  ctg gtg ttt        3630
Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu Leu Val  Leu Val Phe            
    1165                 1170                 1175                        

ggg ggc  att act tac act gat  gtg tta cgc tat gtc  atc ttg gtg        3675
Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg Tyr Val  Ile Leu Val            
    1180                 1185                 1190                        

ggg gca  gct ttc gca gaa tct  aat tcg gga gga gac  gtg gta cac        3720
Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly Gly Asp  Val Val His            
    1195                 1200                 1205                        

ttg gcg  ctc atg gcg acc ttc  aag ata caa cca gtg  ttt atg gtg        3765
Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln Pro Val  Phe Met Val            
    1210                 1215                 1220                        

gca tcg  ttt ctc aaa gcg aga  tgg acc aac cag gag  aac att ttg        3810
Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn Gln Glu  Asn Ile Leu            
    1225                 1230                 1235                        

ttg atg  ttg gcg gct gtt ttc  ttt caa atg gct tat  tac gat gcc        3855
Leu Met  Leu Ala Ala Val Phe  Phe Gln Met Ala Tyr  Tyr Asp Ala            
    1240                 1245                 1250                        

cgc caa  att ctg ctc tgg gag  atc cct gat gtg ttg  aat tca ctg        3900
Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp Val Leu  Asn Ser Leu            
    1255                 1260                 1265                        

gcg gta  gct tgg atg ata ctg  aga gcc ata aca ttc  aca acg aca        3945
Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile Thr Phe  Thr Thr Thr            
    1270                 1275                 1280                        

tca aac  gtg gtt gtt ccg ctg  cta gcc ctg cta aca  ccc ggg ctg        3990
Ser Asn  Val Val Val Pro Leu  Leu Ala Leu Leu Thr  Pro Gly Leu            
    1285                 1290                 1295                        

aga tgc  ttg aat ctg gat gtg  tac agg ata ctg ctg  ttg atg gtc        4035
Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile Leu Leu  Leu Met Val            
    1300                 1305                 1310                        

gga ata  ggc agc ttg atc agg  gag aag agg agt gca  gct gca aaa        4080
Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg Ser Ala  Ala Ala Lys            
    1315                 1320                 1325                        

aag aaa  gga gca agt ctg cta  tgc ttg gct cta gcc  tca aca gga        4125
Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala Leu Ala  Ser Thr Gly            
    1330                 1335                 1340                        

ctt ttc  aac ccc atg atc ctt  gct gct gga ctg att  gca tgt gat        4170
Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly Leu Ile  Ala Cys Asp            
    1345                 1350                 1355                        

ccc aac  cgt aaa cgc gga tgg  ccc gca act gaa gtg  atg aca gct        4215
Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr Glu Val  Met Thr Ala            
    1360                 1365                 1370                        

gtc ggc  cta atg ttt gcc atc  gtc gga ggg ctg gca  gag ctt gac        4260
Val Gly  Leu Met Phe Ala Ile  Val Gly Gly Leu Ala  Glu Leu Asp            
    1375                 1380                 1385                        

att gac  tcc atg gcc att cca  atg act atc gcg ggg  ctc atg ttt        4305
Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile Ala Gly  Leu Met Phe            
    1390                 1395                 1400                        

gct gct  ttc gtg att tct ggg  aaa tca aca gat atg  tgg att gag        4350
Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr Asp Met  Trp Ile Glu            
    1405                 1410                 1415                        

aga acg  gcg gac att tcc tgg  gaa agt gat gca gaa  att aca ggc        4395
Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp Ala Glu  Ile Thr Gly            
    1420                 1425                 1430                        

tcg agc  gaa aga gtt gat gtg  cgg ctt gat gat gat  gga aac ttc        4440
Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp Asp Asp  Gly Asn Phe            
    1435                 1440                 1445                        

cag ctc  atg aat gat cca gga  gca cct tgg aag ata  tgg atg ctc        4485
Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp Lys Ile  Trp Met Leu            
    1450                 1455                 1460                        

aga atg  gtc tgt ctc gcg att  agt gcg tac acc ccc  tgg gca atc        4530
Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr Thr Pro  Trp Ala Ile            
    1465                 1470                 1475                        

ttg ccc  tca gta gtt gga ttt  tgg ata act ctc caa  tac aca aag        4575
Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr Leu Gln  Tyr Thr Lys            
    1480                 1485                 1490                        

aga gga  ggc gtg ttg tgg gac  act ccc tca cca aag  gag tac aaa        4620
Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser Pro Lys  Glu Tyr Lys            
    1495                 1500                 1505                        

aag ggg  gac acg acc acc ggc  gtc tac agg atc atg  act cgt ggg        4665
Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg Ile Met  Thr Arg Gly            
    1510                 1515                 1520                        

ctg ctc  ggc agt tat caa gca  gga gcg ggc gtg atg  gtt gaa ggt        4710
Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly Val Met  Val Glu Gly            
    1525                 1530                 1535                        

gtt ttc  cac acc ctt tgg cat  aca aca aaa gga gcc  gct ttg atg        4755
Val Phe  His Thr Leu Trp His  Thr Thr Lys Gly Ala  Ala Leu Met            
    1540                 1545                 1550                        

agc gga  gag ggc cgc ctg gac  cca tac tgg ggc agt  gtc aag gag        4800
Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp Gly Ser  Val Lys Glu            
    1555                 1560                 1565                        

gat cga  ctt tgt tac gga gga  ccc tgg aaa ttg cag  cac aag tgg        4845
Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys Leu Gln  His Lys Trp            
    1570                 1575                 1580                        

aac ggg  cag gat gag gtg cag  atg att gtg gtg gaa  cct ggc agg        4890
Asn Gly  Gln Asp Glu Val Gln  Met Ile Val Val Glu  Pro Gly Arg            
    1585                 1590                 1595                        

aac gtt  aag aac gtc cag acg  aaa cca ggg gtg ttc  aaa aca cct        4935
Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly Val Phe  Lys Thr Pro            
    1600                 1605                 1610                        

gaa gga  gaa atc ggg gcc gtg  act ttg gac ttc ccc  act gga aca        4980
Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp Phe Pro  Thr Gly Thr            
    1615                 1620                 1625                        

tca ggc  tca cca ata gtg gac  aaa aac ggt gat gtg  att ggg ctt        5025
Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly Asp Val  Ile Gly Leu            
    1630                 1635                 1640                        

tat ggc  aat gga gtc ata atg  ccc aac ggc tca tac  ata agc gcg        5070
Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly Ser Tyr  Ile Ser Ala            
    1645                 1650                 1655                        

ata gtg  cag ggt gaa agg atg  gat gag cca atc cca  gcc gga ttc        5115
Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro Ile Pro  Ala Gly Phe            
    1660                 1665                 1670                        

gaa cct  gag atg ctg agg aaa  aaa cag atc act gta  ctg gat ctc        5160
Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile Thr Val  Leu Asp Leu            
    1675                 1680                 1685                        

cat ccc  ggc gcc ggt aaa aca  agg agg att ctg cca  cag atc atc        5205
His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile Leu Pro  Gln Ile Ile            
    1690                 1695                 1700                        

aaa gag  gcc ata aac aga aga  ctg aga aca gcc gtg  cta gca cca        5250
Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr Ala Val  Leu Ala Pro            
    1705                 1710                 1715                        

acc agg  gtt gtg gct gct gag  atg gct gaa gca ctg  aga gga ctg        5295
Thr Arg  Val Val Ala Ala Glu  Met Ala Glu Ala Leu  Arg Gly Leu            
    1720                 1725                 1730                        

ccc atc  cgg tac cag aca tcc  gca gtg ccc aga gaa  cat aat gga        5340
Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro Arg Glu  His Asn Gly            
    1735                 1740                 1745                        

aat gag  att gtt gat gtc atg  tgt cat gct acc ctc  acc cac agg        5385
Asn Glu  Ile Val Asp Val Met  Cys His Ala Thr Leu  Thr His Arg            
    1750                 1755                 1760                        

ctg atg  tct cct cac agg gtg  ccg aac tac aac ctg  ttc gtg atg        5430
Leu Met  Ser Pro His Arg Val  Pro Asn Tyr Asn Leu  Phe Val Met            
    1765                 1770                 1775                        

gat gag  gct cat ttc acc gac  cca gct agc att gca  gca aga ggt        5475
Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly            
    1780                 1785                 1790                        

tac att  tcc aca aag gtc gag  cta ggg gag gcg gcg  gca ata ttc        5520
Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu Ala Ala  Ala Ile Phe            
    1795                 1800                 1805                        

atg aca  gcc acc cca cca ggc  act tca gat cca ttc  cca gag tcc        5565
Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp Pro Phe  Pro Glu Ser            
    1810                 1815                 1820                        

aat tca  cca att tcc gac tta  cag act gag atc ccg  gat cga gct        5610
Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu Ile Pro  Asp Arg Ala            
    1825                 1830                 1835                        

tgg aac  tct gga tac gaa tgg  atc aca gaa tac acc  ggg aag acg        5655
Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu Tyr Thr  Gly Lys Thr            
    1840                 1845                 1850                        

gtt tgg  ttt gtg cct agt gtc  aag atg ggg aat gag  att gcc ctt        5700
Val Trp  Phe Val Pro Ser Val  Lys Met Gly Asn Glu  Ile Ala Leu            
    1855                 1860                 1865                        

tgc cta  caa cgt gct gga aag  aaa gta gtc caa ttg  aac aga aag        5745
Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val Gln Leu  Asn Arg Lys            
    1870                 1875                 1880                        

tcg tac  gag acg gag tac cca  aaa tgt aag aac gat  gat tgg gac        5790
Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys Asn Asp  Asp Trp Asp            
    1885                 1890                 1895                        

ttt gtt  atc aca aca gac ata  tct gaa atg ggg gct  aac ttc aag        5835
Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys            
    1900                 1905                 1910                        

gcg agc  agg gtg att gac agc  cgg aag agt gtg aaa  cca acc atc        5880
Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser Val Lys  Pro Thr Ile            
    1915                 1920                 1925                        

ata aca  gaa gga gaa ggg aga  gtg atc ctg gga gaa  cca tct gca        5925
Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu Gly Glu  Pro Ser Ala            
    1930                 1935                 1940                        

gtg aca  gca gct agt gcc gcc  cag aga cgt gga cgt  atc ggt aga        5970
Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg            
    1945                 1950                 1955                        

aat ccg  tcg caa gtt ggt gat  gag tac tgt tat ggg  ggg cac acg        6015
Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys Tyr Gly  Gly His Thr            
    1960                 1965                 1970                        

aat gaa  gac gac tcg aac ttc  gcc cat tgg act gag  gca cga atc        6060
Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp Thr Glu  Ala Arg Ile            
    1975                 1980                 1985                        

atg ctg  gac aac atc aac atg  cca aac gga ctg atc  gct caa ttc        6105
Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly Leu Ile  Ala Gln Phe            
    1990                 1995                 2000                        

tac caa  cca gag cgt gag aag  gta tat acc atg gat  ggg gaa tac        6150
Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr Met Asp  Gly Glu Tyr            
    2005                 2010                 2015                        

cgg ctc  aga gga gaa gag aga  aaa aac ttt ctg gaa  ctg ttg agg        6195
Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe Leu Glu  Leu Leu Arg            
    2020                 2025                 2030                        

act gca  gat ctg cca gtt tgg  ctg gct tac aag gtt  gca gcg gct        6240
Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr Lys Val  Ala Ala Ala            
    2035                 2040                 2045                        

gga gtg  tca tac cac gac cgg  agg tgg tgc ttt gat  ggt cct agg        6285
Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys Phe Asp  Gly Pro Arg            
    2050                 2055                 2060                        

aca aac  aca att tta gaa gac  aac aac gaa gtg gaa  gtc atc acg        6330
Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu Val Glu  Val Ile Thr            
    2065                 2070                 2075                        

aag ctt  ggt gaa agg aag att  ctg agg ccg cgc tgg  att gac gcc        6375
Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro Arg Trp  Ile Asp Ala            
    2080                 2085                 2090                        

agg gtg  tac tcg gat cac cag  gca cta aag gcg ttc  aag gac ttc        6420
Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys Ala Phe  Lys Asp Phe            
    2095                 2100                 2105                        

gcc tcg  gga aaa cgt tct cag  ata ggg ctc att gag  gtt ctg gga        6465
Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu Ile Glu  Val Leu Gly            
    2110                 2115                 2120                        

aag atg  cct gag cac ttc atg  ggg aag aca tgg gaa  gca ctt gac        6510
Lys Met  Pro Glu His Phe Met  Gly Lys Thr Trp Glu  Ala Leu Asp            
    2125                 2130                 2135                        

acc atg  tac gtt gtg gcc act  gca gag aaa gga gga  aga gct cac        6555
Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys Gly Gly  Arg Ala His            
    2140                 2145                 2150                        

aga atg  gcc ctg gag gaa ctg  cca gat gct ctt cag  aca att gcc        6600
Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala Leu Gln  Thr Ile Ala            
    2155                 2160                 2165                        

ttg att  gcc tta ttg agt gtg  atg acc atg gga gta  ttc ttc ctc        6645
Leu Ile  Ala Leu Leu Ser Val  Met Thr Met Gly Val  Phe Phe Leu            
    2170                 2175                 2180                        

ctc atg  cag cgg aag ggc att  gga aag ata ggt ttg  gga ggc gct        6690
Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile Gly Leu  Gly Gly Ala            
    2185                 2190                 2195                        

gtc ttg  gga gtc gcg acc ttt  ttc tgt tgg atg gct  gaa gtt cca        6735
Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp Met Ala  Glu Val Pro            
    2200                 2205                 2210                        

gga acg  aag atc gcc gga atg  ttg ctg ctc tcc ctt  ctc ttg atg        6780
Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu Ser Leu  Leu Leu Met            
    2215                 2220                 2225                        

att gtg  cta att cct gag cca  gag aag caa cgt tcg  cag aca gac        6825
Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Ser  Gln Thr Asp            
    2230                 2235                 2240                        

aac cag  cta gcc gtg ttc ctg  att tgt gtc atg acc  ctt gtg agc        6870
Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val Met Thr  Leu Val Ser            
    2245                 2250                 2255                        

gca gtg  gca gcc aac gag atg  ggt tgg cta gat aag  acc aag agt        6915
Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu Asp Lys  Thr Lys Ser            
    2260                 2265                 2270                        

gac ata  agc agt ttg ttt ggg  caa aga att gag gtc  aag gag aat        6960
Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile Glu Val  Lys Glu Asn            
    2275                 2280                 2285                        

ttc agc  atg gga gag ttt ctt  ttg gac ttg agg cct  gca aca gcc        7005
Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu Arg Pro  Ala Thr Ala            
    2290                 2295                 2300                        

tgg tca  ctg tac gct gtg aca  aca gcg gtc ctc act  cca ctg cta        7050
Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val Leu Thr  Pro Leu Leu            
    2305                 2310                 2315                        

aag cat  ttg atc acg tca gat  tac atc aac acc tca  ttg acc tca        7095
Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn Thr Ser  Leu Thr Ser            
    2320                 2325                 2330                        

ata aac  gtt cag gca agt gca  cta ttc aca ctc gcg  cga ggc ttc        7140
Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr Leu Ala  Arg Gly Phe            
    2335                 2340                 2345                        

ccc ttc  gtc gat gtt gga gtg  tcg gct ctc ctg cta  gca gcc gga        7185
Pro Phe  Val Asp Val Gly Val  Ser Ala Leu Leu Leu  Ala Ala Gly            
    2350                 2355                 2360                        

tgc tgg  gga caa gtc acc ctc  acc gtt acg gta aca  gcg gca aca        7230
Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr Val Thr  Ala Ala Thr            
    2365                 2370                 2375                        

ctc ctt  ttt tgc cac tat gcc  tac atg gtt ccc ggt  tgg caa gct        7275
Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val Pro Gly  Trp Gln Ala            
    2380                 2385                 2390                        

gag gca  atg cgc tca gcc cag  cgg cgg aca gcg gcc  gga atc atg        7320
Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr Ala Ala  Gly Ile Met            
    2395                 2400                 2405                        

aag aac  gct gta gtg gat ggc  atc gtg gcc acg gac  gtc cca gaa        7365
Lys Asn  Ala Val Val Asp Gly  Ile Val Ala Thr Asp  Val Pro Glu            
    2410                 2415                 2420                        

tta gag  cgc acc aca ccc atc  atg cag aag aaa gtt  gga cag atc        7410
Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys Lys Val  Gly Gln Ile            
    2425                 2430                 2435                        

atg ctg  atc ttg gtg tct cta  gct gca gta gta gtg  aac ccg tct        7455
Met Leu  Ile Leu Val Ser Leu  Ala Ala Val Val Val  Asn Pro Ser            
    2440                 2445                 2450                        

gtg aag  aca gta cga gaa gcc  gga att ttg atc acg  gcc gca gcg        7500
Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu Ile Thr  Ala Ala Ala            
    2455                 2460                 2465                        

gtg acg  ctt tgg gag aat gga  gca agc tct gtt tgg  aac gca aca        7545
Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser Val Trp  Asn Ala Thr            
    2470                 2475                 2480                        

act gcc  atc gga ctc tgc cac  atc atg cgt ggg ggt  tgg ttg tca        7590
Thr Ala  Ile Gly Leu Cys His  Ile Met Arg Gly Gly  Trp Leu Ser            
    2485                 2490                 2495                        

tgt cta  tcc ata aca tgg aca  ctc ata aag aac atg  gaa aaa cca        7635
Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys Asn Met  Glu Lys Pro            
    2500                 2505                 2510                        

gga cta  aaa aga ggt ggg gca  aaa gga cgc acc ttg  gga gag gtt        7680
Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg Thr Leu  Gly Glu Val            
    2515                 2520                 2525                        

tgg aaa  gaa aga ctc aac cag  atg aca aaa gaa gag  ttc act agg        7725
Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys Glu Glu  Phe Thr Arg            
    2530                 2535                 2540                        

tac cgc  aaa gag gcc atc atc  gaa gtc gat cgc tca  gcg gca aaa        7770
Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp Arg Ser  Ala Ala Lys            
    2545                 2550                 2555                        

cac gcc  agg aaa gaa ggc aat  gtc act gga ggg cat  cca gtc tct        7815
His Ala  Arg Lys Glu Gly Asn  Val Thr Gly Gly His  Pro Val Ser            
    2560                 2565                 2570                        

agg ggc  aca gca aaa ctg aga  tgg ctg gtc gaa cgg  agg ttt ctc        7860
Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val Glu Arg  Arg Phe Leu            
    2575                 2580                 2585                        

gaa ccg  gtc gga aaa gtg att  gac ctt gga tgt gga  aga ggc ggt        7905
Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly Cys Gly  Arg Gly Gly            
    2590                 2595                 2600                        

tgg tgt  tac tat atg gca acc  caa aaa aga gtc caa  gaa gtc aga        7950
Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg Val Gln  Glu Val Arg            
    2605                 2610                 2615                        

ggg tac  aca aag ggc ggt ccc  gga cat gaa gag ccc  caa cta gtg        7995
Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu Glu Pro  Gln Leu Val            
    2620                 2625                 2630                        

caa agt  tat gga tgg aac att  gtc acc atg aag agt  gga gtg gat        8040
Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met Lys Ser  Gly Val Asp            
    2635                 2640                 2645                        

gtg ttc  tac aga cct tct gag  tgt tgt gac acc ctc  ctt tgt gac        8085
Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp Thr Leu  Leu Cys Asp            
    2650                 2655                 2660                        

atc gga  gag tcc tcg tca agt  gct gag gtt gaa gag  cat agg acg        8130
Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val Glu Glu  His Arg Thr            
    2665                 2670                 2675                        

att cgg  gtc ctt gaa atg gtt  gag gac tgg ctg cac  cga ggg cca        8175
Ile Arg  Val Leu Glu Met Val  Glu Asp Trp Leu His  Arg Gly Pro            
    2680                 2685                 2690                        

agg gaa  ttt tgc gtg aag gtg  ctc tgc ccc tac atg  ccg aaa gtc        8220
Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro Tyr Met  Pro Lys Val            
    2695                 2700                 2705                        

ata gag  aag atg gag ctg ctc  caa cgc cgg tat ggg  ggg gga ctg        8265
Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg Tyr Gly  Gly Gly Leu            
    2710                 2715                 2720                        

gtc aga  aac cca ctc tca cgg  aat tcc acg cac gag  atg tat tgg        8310
Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr His Glu  Met Tyr Trp            
    2725                 2730                 2735                        

gtg agt  cga gct tca ggc aat  gtg gta cat tca gtg  aat atg acc        8355
Val Ser  Arg Ala Ser Gly Asn  Val Val His Ser Val  Asn Met Thr            
    2740                 2745                 2750                        

agc cag  gtg ctc cta gga aga  atg gaa aaa agg acc  tgg aag gga        8400
Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys Arg Thr  Trp Lys Gly            
    2755                 2760                 2765                        

ccc caa  tac gag gaa gat gta  aac ttg gga agt gga  acc agg gcg        8445
Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly Ser Gly  Thr Arg Ala            
    2770                 2775                 2780                        

gtg gga  aaa ccc ctg ctc aac  tca gac acc agt aaa  atc aag aac        8490
Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr Ser Lys  Ile Lys Asn            
    2785                 2790                 2795                        

agg att  gaa cga ctc agg cgt  gag tac agt tcg acg  tgg cac cac        8535
Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser Ser Thr  Trp His His            
    2800                 2805                 2810                        

gat gag  aac cac cca tat aga  acc tgg aac tat cac  ggc agt tat        8580
Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn Tyr His  Gly Ser Tyr            
    2815                 2820                 2825                        

gat gtg  aag ccc aca ggc tcc  gcc agt tcg ctg gtc  aat gga gtg        8625
Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser Leu Val  Asn Gly Val            
    2830                 2835                 2840                        

gtc agg  ctc ctc tca aaa cca  tgg gac acc atc acg  aat gtt acc        8670
Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr Ile Thr  Asn Val Thr            
    2845                 2850                 2855                        

acc atg  gcc atg act gac act  act ccc ttc ggg cag  cag cga gtg        8715
Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe Gly Gln  Gln Arg Val            
    2860                 2865                 2870                        

ttc aaa  gag aag gtg gac acg  aaa gct cct gaa ccg  cca gaa gga        8760
Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro Glu Pro  Pro Glu Gly            
    2875                 2880                 2885                        

gtg aag  tac gtg ctc aac gag  acc acc aac tgg ttg  tgg gcg ttt        8805
Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn Trp Leu  Trp Ala Phe            
    2890                 2895                 2900                        

ttg gcc  aga gaa aaa cgt ccc  aga atg tgc tct cga  gag gaa ttc        8850
Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys Ser Arg  Glu Glu Phe            
    2905                 2910                 2915                        

ata aga  aag gtc aac agc aat  gca gct ttg ggt gcc  atg ttt gaa        8895
Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu Gly Ala  Met Phe Glu            
    2920                 2925                 2930                        

gag cag  aat caa tgg agg agc  gcc aga gaa gca gtt  gaa gat cca        8940
Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu Ala Val  Glu Asp Pro            
    2935                 2940                 2945                        

aaa ttt  tgg gag atg gtg gat  gag gag cgc gag gca  cat ctg cgg        8985
Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg Glu Ala  His Leu Arg            
    2950                 2955                 2960                        

ggg gaa  tgt cac act tgc att  tac aac atg atg gga  aag aga gag        9030
Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met Met Gly  Lys Arg Glu            
    2965                 2970                 2975                        

aaa aaa  ccc gga gag ttc gga  aag gcc aag gga agc  aga gcc att        9075
Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys Gly Ser  Arg Ala Ile            
    2980                 2985                 2990                        

tgg ttc  atg tgg ctc gga gct  cgc ttt ctg gag ttc  gag gct ctg        9120
Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu Glu Phe  Glu Ala Leu            
    2995                 3000                 3005                        

ggt ttt  ctc aat gaa gac cac  tgg ctt gga aga aag  aac tca gga        9165
Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly Arg Lys  Asn Ser Gly            
    3010                 3015                 3020                        

gga ggt  gtc gag ggc ttg ggc  ctc caa aaa ctg ggt  tac atc ctg        9210
Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys Leu Gly  Tyr Ile Leu            
    3025                 3030                 3035                        

cgt gaa  gtt ggc acc cgg cct  ggg ggc aag atc tat  gct gat gac        9255
Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys Ile Tyr  Ala Asp Asp            
    3040                 3045                 3050                        

aca gct  ggc tgg gac acc cgc  atc acg aga gct gac  ttg gaa aat        9300
Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg Ala Asp  Leu Glu Asn            
    3055                 3060                 3065                        

gaa gct  aag gtg ctt gag ctg  ctt gat ggg gaa cat  cgg cgt ctt        9345
Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly Glu His  Arg Arg Leu            
    3070                 3075                 3080                        

gcc agg  gcc atc att gag ctc  acc tat cgt cac aaa  gtt gtg aaa        9390
Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg His Lys  Val Val Lys            
    3085                 3090                 3095                        

gtg atg  cgc ccg gct gct gat  gga aga acc gtc atg  gat gtt atc        9435
Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr Val Met  Asp Val Ile            
    3100                 3105                 3110                        

tcc aga  gaa gat cag agg ggg  agt gga caa gtt gtc  acc tac gcc        9480
Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln Val Val  Thr Tyr Ala            
    3115                 3120                 3125                        

cta aac  act ttc acc aac ctg  gcc gtc cag ctg gtg  agg atg atg        9525
Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln Leu Val  Arg Met Met            
    3130                 3135                 3140                        

gaa ggg  gaa gga gtg att ggc  cca gat gat gtg gag  aaa ctc aca        9570
Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp Val Glu  Lys Leu Thr            
    3145                 3150                 3155                        

aaa ggg  aaa gga ccc aaa gtc  agg acc tgg ctg ttt  gag aat ggg        9615
Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp Leu Phe  Glu Asn Gly            
    3160                 3165                 3170                        

gaa gaa  aga ctc agc cgc atg  gct gtc agt gga gat  gac tgt gtg        9660
Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser Gly Asp  Asp Cys Val            
    3175                 3180                 3185                        

gta aag  ccc ctg gac gat cgc  ttt gcc acc tcg ctc  cac ttc ctc        9705
Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr Ser Leu  His Phe Leu            
    3190                 3195                 3200                        

aat gct  atg tca aag gtt cgc  aaa gac atc caa gag  tgg aaa ccg        9750
Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile Gln Glu  Trp Lys Pro            
    3205                 3210                 3215                        

tca act  gga tgg tat gat tgg  cag cag gtt cca ttt  tgc tca aac        9795
Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val Pro Phe  Cys Ser Asn            
    3220                 3225                 3230                        

cat ttc  act gaa ttg atc atg  aaa gat gga aga aca  ctg gtg gtt        9840
His Phe  Thr Glu Leu Ile Met  Lys Asp Gly Arg Thr  Leu Val Val            
    3235                 3240                 3245                        

cca tgc  cga gga cag gat gaa  ttg gta ggc aga gct  cgc ata tct        9885
Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly Arg Ala  Arg Ile Ser            
    3250                 3255                 3260                        

cca ggg  gcc gga tgg aac gtc  cgc gac act gct tgt  ctg gct aag        9930
Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr Ala Cys  Leu Ala Lys            
    3265                 3270                 3275                        

tct tat  gcc cag atg tgg ctg  ctt ctg tac ttc cac  aga aga gac        9975
Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr Phe His  Arg Arg Asp            
    3280                 3285                 3290                        

ctg cgg  ctc atg gcc aac gcc  att tgc tcc gct gtc  cct gtg aat       10020
Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser Ala Val  Pro Val Asn            
    3295                 3300                 3305                        

tgg gtc  cct acc gga aga acc  acg tgg tcc atc cat  gca gga gga       10065
Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser Ile His  Ala Gly Gly            
    3310                 3315                 3320                        

gag tgg  atg aca aca gag gac  atg ttg gag gtc tgg  aac cgt gtt       10110
Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu Val Trp  Asn Arg Val            
    3325                 3330                 3335                        

tgg ata  gag gag aat gaa tgg  atg gaa gac aaa acc  cca gtg gag       10155
Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp Lys Thr  Pro Val Glu            
    3340                 3345                 3350                        

aaa tgg  agt gac gtc cca tat  tca gga aaa cga gag  gac atc tgg       10200
Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys Arg Glu  Asp Ile Trp            
    3355                 3360                 3365                        

tgt ggc  agc ctg att ggc aca  aga gcc cga gcc acg  tgg gca gaa       10245
Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg Ala Thr  Trp Ala Glu            
    3370                 3375                 3380                        

aac atc  cag gtg gct atc aac  caa gtc aga gca atc  atc gga gat       10290
Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg Ala Ile  Ile Gly Asp            
    3385                 3390                 3395                        

gag aag  tat gtg gat tac atg  agt tca cta aag aga  tat gaa gac       10335
Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu Lys Arg  Tyr Glu Asp            
    3400                 3405                 3410                        

aca act  ttg gtt gag gac aca  gta ctg tagatattta atcaattgta          10382
Thr Thr  Leu Val Glu Asp Thr  Val Leu                                     
    3415                 3420                                             

aatagacaat ataagtatgc ataaaagtgt agttttatag tagtatttag tggtgttagt    10442

gtaaatagtt aagaaaattt tgaggagaaa gtcaggccgg gaagttcccg ccaccggaag    10502

ttgagtagac ggtgctgcct gcgactcaac cccaggagga ctgggtgaac aaagccgcga    10562

agtgatccat gtaagccctc agaaccgtct cggaaggagg accccacatg ttgtaacttc    10622

aaagcccaat gtcagaccac gctacggcgt gctactctgc ggagagtgca gtctgcgata    10682

gtgccccagg aggactgggt taacaaaggc aaaccaacgc cccacgcggc cctagccccg    10742

gtaatggtgt taaccagggc gaaaggacta gaggttagag gagaccccgc ggtttaaagt    10802

gcacggccca gcctggctga agctgtaggt caggggaagg actagaggtt agtggagacc    10862

ccgtgccaca aaacaccaca acaaaacagc atattgacac ctgggataga ctaggagatc    10922

ttctgctctg cacaaccagc cacacggcac agtgcgccga caatggtggc tggtggtgcg    10982

agaacacagg atct                                                      10996


<210>  4
<211>  3422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Ser Val Thr Met Leu Leu Met 
            100                 105                 110         


Leu Leu Pro Thr Ala Leu Ala Phe His Leu Thr Thr Arg Gly Gly Glu 
        115                 120                 125             


Pro His Met Ile Val Ser Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe 
    130                 135                 140                 


Lys Thr Ser Ala Gly Val Asn Met Cys Thr Leu Ile Ala Met Asp Leu 
145                 150                 155                 160 


Gly Glu Leu Cys Glu Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr 
                165                 170                 175     


Glu Ala Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Ala Thr Asp Thr 
            180                 185                 190         


Trp Val Thr Tyr Gly Thr Cys Ser Gln Thr Gly Glu His Arg Arg Asp 
        195                 200                 205             


Lys Arg Ser Val Ala Leu Ala Pro His Val Gly Leu Gly Leu Glu Thr 
    210                 215                 220                 


Arg Ala Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln 
225                 230                 235                 240 


Lys Val Glu Thr Trp Ala Leu Arg His Pro Gly Phe Thr Val Ile Ala 
                245                 250                 255     


Leu Phe Leu Ala His Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile 
            260                 265                 270         


Ile Phe Ile Leu Leu Met Leu Val Thr Pro Ser Met Ala Met Arg Cys 
        275                 280                 285             


Val Gly Ile Gly Asn Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr 
    290                 295                 300                 


Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr Thr Met Ala 
305                 310                 315                 320 


Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr Glu Val Thr 
                325                 330                 335     


Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn 
            340                 345                 350         


Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Thr Leu Val 
        355                 360                 365             


Glu Glu Gln Asp Ala Asn Phe Val Cys Arg Arg Thr Phe Val Asp Arg 
    370                 375                 380                 


Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr 
385                 390                 395                 400 


Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln 
                405                 410                 415     


Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His Thr Gly Asp 
            420                 425                 430         


Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly Thr Thr Ala Thr 
        435                 440                 445             


Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly 
    450                 455                 460                 


Thr Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu 
465                 470                 475                 480 


Met Val Leu Leu Thr Met Lys Glu Arg Ser Trp Leu Val His Lys Gln 
                485                 490                 495     


Trp Phe Pro Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser 
            500                 505                 510         


Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala 
        515                 520                 525             


His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala 
    530                 535                 540                 


Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr 
545                 550                 555                 560 


Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys 
                565                 570                 575     


Leu Thr Leu Lys Gly Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys 
            580                 585                 590         


Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val Leu Val Gln 
        595                 600                 605             


Val Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr 
    610                 615                 620                 


Gln Asp Glu Lys Gly Ala Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn 
625                 630                 635                 640 


Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu Ala Glu Pro 
                645                 650                 655     


Pro Phe Gly Glu Ser Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu 
            660                 665                 670         


Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu 
        675                 680                 685             


Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala 
    690                 695                 700                 


Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr Ser Met Gly Lys Leu 
705                 710                 715                 720 


Val His Gln Val Phe Gly Thr Ala Tyr Gly Val Leu Phe Ser Gly Val 
                725                 730                 735     


Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly 
            740                 745                 750         


Leu Asn Ser Arg Asn Thr Ser Leu Ser Met Met Cys Ile Ala Val Gly 
        755                 760                 765             


Met Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys 
    770                 775                 780                 


Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe 
785                 790                 795                 800 


Ile His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro 
                805                 810                 815     


Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu 
            820                 825                 830         


Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp 
        835                 840                 845             


Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val 
    850                 855                 860                 


Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala 
865                 870                 875                 880 


Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys 
                885                 890                 895     


Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr 
            900                 905                 910         


Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg 
        915                 920                 925             


Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser 
    930                 935                 940                 


Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp 
945                 950                 955                 960 


Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser 
                965                 970                 975     


Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu 
            980                 985                 990         


Glu Arg Ala Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
        995                 1000                 1005             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1010                 1015                 1020             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1025                 1030                 1035             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1040                 1045                 1050             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1070                 1075                 1080             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1085                 1090                 1095             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1100                 1105                 1110             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1115                 1120                 1125             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1130                 1135                 1140             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1145                 1150                 1155             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1160                 1165                 1170             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1175                 1180                 1185             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1190                 1195                 1200             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1205                 1210                 1215             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1220                 1225                 1230             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1235                 1240                 1245             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1250                 1255                 1260             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1265                 1270                 1275             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1280                 1285                 1290             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1295                 1300                 1305             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1310                 1315                 1320             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1325                 1330                 1335             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1340                 1345                 1350             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1355                 1360                 1365             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1370                 1375                 1380             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1385                 1390                 1395             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1400                 1405                 1410             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1415                 1420                 1425             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1430                 1435                 1440             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1445                 1450                 1455             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1460                 1465                 1470             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1475                 1480                 1485             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1490                 1495                 1500             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1505                 1510                 1515             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1520                 1525                 1530             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1535                 1540                 1545             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1550                 1555                 1560             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1565                 1570                 1575             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1580                 1585                 1590             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1595                 1600                 1605             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1610                 1615                 1620             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1625                 1630                 1635             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1640                 1645                 1650             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1655                 1660                 1665             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1670                 1675                 1680             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1685                 1690                 1695             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1700                 1705                 1710             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1715                 1720                 1725             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1730                 1735                 1740             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1745                 1750                 1755             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1760                 1765                 1770             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1775                 1780                 1785             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1790                 1795                 1800             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1805                 1810                 1815             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1820                 1825                 1830             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1835                 1840                 1845             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1850                 1855                 1860             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1865                 1870                 1875             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1880                 1885                 1890             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1895                 1900                 1905             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1910                 1915                 1920             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1925                 1930                 1935             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1940                 1945                 1950             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1955                 1960                 1965             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1970                 1975                 1980             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    1985                 1990                 1995             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2000                 2005                 2010             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2015                 2020                 2025             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2030                 2035                 2040             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2045                 2050                 2055             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2060                 2065                 2070             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2075                 2080                 2085             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2090                 2095                 2100             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2105                 2110                 2115             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2120                 2125                 2130             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2135                 2140                 2145             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2150                 2155                 2160             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2165                 2170                 2175             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2180                 2185                 2190             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2195                 2200                 2205             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2210                 2215                 2220             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2225                 2230                 2235             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2240                 2245                 2250             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2255                 2260                 2265             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2270                 2275                 2280             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2285                 2290                 2295             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2300                 2305                 2310             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2315                 2320                 2325             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2330                 2335                 2340             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2345                 2350                 2355             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2360                 2365                 2370             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2375                 2380                 2385             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2390                 2395                 2400             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2405                 2410                 2415             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2420                 2425                 2430             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2435                 2440                 2445             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2465                 2470                 2475             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2480                 2485                 2490             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2495                 2500                 2505             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2510                 2515                 2520             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2525                 2530                 2535             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2540                 2545                 2550             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2555                 2560                 2565             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2570                 2575                 2580             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2585                 2590                 2595             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2600                 2605                 2610             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2615                 2620                 2625             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2630                 2635                 2640             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2645                 2650                 2655             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2660                 2665                 2670             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2675                 2680                 2685             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2690                 2695                 2700             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2705                 2710                 2715             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2720                 2725                 2730             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2735                 2740                 2745             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2750                 2755                 2760             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2765                 2770                 2775             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2780                 2785                 2790             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2795                 2800                 2805             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2810                 2815                 2820             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2825                 2830                 2835             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2840                 2845                 2850             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2855                 2860                 2865             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2870                 2875                 2880             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2885                 2890                 2895             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2900                 2905                 2910             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2915                 2920                 2925             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2930                 2935                 2940             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2945                 2950                 2955             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2960                 2965                 2970             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2975                 2980                 2985             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    2990                 2995                 3000             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3005                 3010                 3015             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3020                 3025                 3030             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3035                 3040                 3045             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3050                 3055                 3060             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3065                 3070                 3075             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3080                 3085                 3090             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3095                 3100                 3105             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3110                 3115                 3120             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3125                 3130                 3135             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3140                 3145                 3150             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3155                 3160                 3165             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3185                 3190                 3195             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3230                 3235                 3240             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3245                 3250                 3255             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3365                 3370                 3375             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3380                 3385                 3390             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3395                 3400                 3405             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3410                 3415                 3420         


<210>  5
<211>  10990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant West Nile virus/Dengue-3 virus chimera


<220>
<221>  CDS
<222>  (97)..(10356)

<400>  5
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agt tcg aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga aca tcg ctc tgt ctc atg atg atg tta cca gca aca ctt        450
Lys Lys Arg Thr Ser Leu Cys Leu Met Met Met Leu Pro Ala Thr Leu           
        105                 110                 115                       

gct ttc cac tta act tca cga gat gga gag ccg cgc atg att gtg ggg        498
Ala Phe His Leu Thr Ser Arg Asp Gly Glu Pro Arg Met Ile Val Gly           
    120                 125                 130                           

aag aat gaa aga gga aaa tcc cta ctt ttc aag aca gcc tct gga atc        546
Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ala Ser Gly Ile           
135                 140                 145                 150           

aac atg tgc aca ctc ata gcc atg gat ctg gga gag atg tgt gat gac        594
Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Asp Asp           
                155                 160                 165               

acg gtc act tac aaa tgc ccc cac att acc gaa gtg gag cct gaa gac        642
Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val Glu Pro Glu Asp           
            170                 175                 180                   

att gac tgc tgg tgc aac ctt aca tcg aca tgg gtg act tat gga aca        690
Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Thr Tyr Gly Thr           
        185                 190                 195                       

tgc aat caa gct gga gag cat aga cgc gat aag aga tca gtg gcg tta        738
Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala Leu           
    200                 205                 210                           

gct ccc cat gtt ggc atg gga ctg gac aca cgc act caa acc tgg atg        786
Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr Gln Thr Trp Met           
215                 220                 225                 230           

tcg gct gaa gga gct tgg aga caa gtc gag aag gta gag aca tgg gcc        834
Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val Glu Thr Trp Ala           
                235                 240                 245               

ctt agg cac cca ggg ttt acc ata cta gcc cta ttt ctt gcc cat tac        882
Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe Leu Ala His Tyr           
            250                 255                 260                   

ata ggc act tcc ttg acc cag aaa gtg gtt att ttt ata cta tta atg        930
Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe Ile Leu Leu Met           
        265                 270                 275                       

ctg gtt acc cca tcc atg aca atg aga tgt gta gga gta gga aac aga        978
Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly Val Gly Asn Arg           
    280                 285                 290                           

gat ttt gtg gaa ggc cta tcg gga gct acg tgg gtt gac gtg gtg ctc       1026
Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val Leu           
295                 300                 305                 310           

gag cac ggt ggg tgt gtg act acc atg gct aag aac aag ccc acg ctg       1074
Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu           
                315                 320                 325               

gac ata gag ctt cag aag acc gag gcc acc caa ctg gcg acc cta agg       1122
Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr Leu Arg           
            330                 335                 340                   

aag cta tgc att gag gga aaa att acc aac ata aca acc gac tca aga       1170
Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr Thr Asp Ser Arg           
        345                 350                 355                       

tgt ccc acc caa ggg gaa gcg att tta cct gag gag cag gac cag aac       1218
Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro Glu Glu Gln Asp Gln Asn           
    360                 365                 370                           

tac gtg tgt aag cat aca tac gtg gac aga ggc tgg gga aac ggt tgt       1266
Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp Gly Asn Gly Cys           
375                 380                 385                 390           

ggt ttg ttt ggc aag gga agc ttg gtg aca tgc gcg aaa ttt caa tgt       1314
Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Gln Cys           
                395                 400                 405               

tta gaa tca ata gag gga aaa gtg gtg caa cat gag aac ctc aaa tac       1362
Leu Glu Ser Ile Glu Gly Lys Val Val Gln His Glu Asn Leu Lys Tyr           
            410                 415                 420                   

acc gtc atc atc aca gtg cac aca gga gac caa cac cag gtg gga aat       1410
Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His Gln Val Gly Asn           
        425                 430                 435                       

gaa acg cag gga gtc acg gct gag ata aca ccc cag gca tca acc gct       1458
Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln Ala Ser Thr Ala           
    440                 445                 450                           

gaa gcc att tta cct gaa tat gga acc ctc ggg cta gaa tgc tca cca       1506
Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys Ser Pro           
455                 460                 465                 470           

cgg aca ggt ttg gat ttc aat gaa atg atc tca ttg aca atg aag aac       1554
Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Ser Leu Thr Met Lys Asn           
                475                 480                 485               

aaa gca tgg atg gta cat aga caa tgg ttc ttt gac tta ccc cta cca       1602
Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp Leu Pro Leu Pro           
            490                 495                 500                   

tgg aca tca gga gct aca gca gaa aca cca act tgg aac agg aaa gag       1650
Trp Thr Ser Gly Ala Thr Ala Glu Thr Pro Thr Trp Asn Arg Lys Glu           
        505                 510                 515                       

ctt ctt gtg aca ttt aaa aat gca cat gca aaa aag caa gaa gta gtt       1698
Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys Gln Glu Val Val           
    520                 525                 530                           

gtt ctt gga tca caa gag gga gca atg cat aca gca ctg aca gga gct       1746
Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala           
535                 540                 545                 550           

aca gag atc caa acc tca gga ggc aca agt atc ttt gcg ggg cac tta       1794
Thr Glu Ile Gln Thr Ser Gly Gly Thr Ser Ile Phe Ala Gly His Leu           
                555                 560                 565               

aaa tgt aga ctc aag atg gac aaa ttg gaa ctc aag ggg atg agc tat       1842
Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys Gly Met Ser Tyr           
            570                 575                 580                   

gca atg tgc ttg agt agc ttt gtg ttg aag aaa gaa gtc tcc gaa acg       1890
Ala Met Cys Leu Ser Ser Phe Val Leu Lys Lys Glu Val Ser Glu Thr           
        585                 590                 595                       

cag cat ggg aca ata ctc att aag gtt gag tac aaa ggg gaa gat gca       1938
Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu Asp Ala           
    600                 605                 610                           

ccc tgc aag att cct ttc tcc acg gag gat gga caa gga aaa gct cac       1986
Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys Ala His           
615                 620                 625                 630           

aat ggc aga ctg atc aca gcc aat cca gtg gtg acc aag aag gag gag       2034
Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys Glu Glu           
                635                 640                 645               

cct gtc aac att gag gct gaa cct cct ttt gga gaa agt aac ata gta       2082
Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn Ile Val           
            650                 655                 660                   

att gga att gga gac aaa gcc ctg aaa atc aac tgg tac aag aag gga       2130
Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp Tyr Lys Lys Gly           
        665                 670                 675                       

agc tcg att ggg aag atg ttc gag gcc act gcc aga ggt gca agg cgc       2178
Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg           
    680                 685                 690                           

atg gcc atc ttg gga gac aca gcc tgg gac ttt gga tca gtg ggt ggt       2226
Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly           
695                 700                 705                 710           

gtt ttg aat tca tta ggg aaa atg gtc cac caa ata ttt ggg agt gct       2274
Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser Ala           
                715                 720                 725               

tac aca gcc cta ttt ggt gga gtc tcc tgg atg atg aaa att gga ata       2322
Tyr Thr Ala Leu Phe Gly Gly Val Ser Trp Met Met Lys Ile Gly Ile           
            730                 735                 740                   

ggt gtc ctc tta acc tgg ata ggg ttg aac tca aaa aat act tct atg       2370
Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser Met           
        745                 750                 755                       

tca ttt tca tgc atc gcg ata gga atc att aca ctc tat ctg gga gcc       2418
Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile Thr Leu Tyr Leu Gly Ala           
    760                 765                 770                           

gtg gtg caa gct gac tcc gga tgt gcc ata gac atc agc cgg caa gag       2466
Val Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile Ser Arg Gln Glu           
775                 780                 785                 790           

ctg aga tgt gga agt gga gtg ttc ata cac aat gat gtg gag gct tgg       2514
Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val Glu Ala Trp           
                795                 800                 805               

atg gac cgg tac aag tat tac cct gaa acg cca caa ggc cta gcc aag       2562
Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly Leu Ala Lys           
            810                 815                 820                   

atc att cag aaa gct cat aag gaa gga gtg tgc ggt cta cga tca gtt       2610
Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu Arg Ser Val           
        825                 830                 835                       

tcc aga ctg gag cat caa atg tgg gaa gca gtg aag gac gag ctg aac       2658
Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp Glu Leu Asn           
    840                 845                 850                           

act ctt ttg aag gag aat ggt gtg gac ctt agt gtc gtg gtt gag aaa       2706
Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val Val Glu Lys           
855                 860                 865                 870           

cag gag gga atg tac aag tca gca cct aaa cgc ctc acc gcc acc acg       2754
Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr Ala Thr Thr           
                875                 880                 885               

gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag agt att tta ttt       2802
Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser Ile Leu Phe           
            890                 895                 900                   

gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat ggt ccg gag acc       2850
Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly Pro Glu Thr           
        905                 910                 915                       

aag gaa tgt ccg act cag aat cgc gct tgg aat agc tta gaa gtg gag       2898
Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu Glu Val Glu           
    920                 925                 930                           

gat ttt gga ttt ggt ctc acc agc act cgg atg ttc ctg aag gtc aga       2946
Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu Lys Val Arg           
935                 940                 945                 950           

gag agc aac aca act gaa tgt gac tcg aag atc att gga acg gct gtc       2994
Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly Thr Ala Val           
                955                 960                 965               

aag aac aac ttg gcg atc cac agt gac ctg tcc tat tgg att gaa agc       3042
Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp Ile Glu Ser           
            970                 975                 980                   

agg ctc aat gat acg tgg aag ctt gaa agg gca gtt ctg ggt gaa gtc       3090
Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val Leu Gly Glu Val           
        985                 990                 995                       

aaa tca  tgt acg tgg cct gag  acg cat acc ttg tgg  ggc gat gga        3135
Lys Ser  Cys Thr Trp Pro Glu  Thr His Thr Leu Trp  Gly Asp Gly            
    1000                 1005                 1010                        

atc ctt  gag agt gac ttg ata  ata cca gtc aca ctg  gcg gga cca        3180
Ile Leu  Glu Ser Asp Leu Ile  Ile Pro Val Thr Leu  Ala Gly Pro            
    1015                 1020                 1025                        

cga agc  aat cac aat cgg aga  cct ggg tac aag aca  caa aac cag        3225
Arg Ser  Asn His Asn Arg Arg  Pro Gly Tyr Lys Thr  Gln Asn Gln            
    1030                 1035                 1040                        

ggc cca  tgg gac gaa ggc cgg  gta gag att gac ttc  gat tac tgc        3270
Gly Pro  Trp Asp Glu Gly Arg  Val Glu Ile Asp Phe  Asp Tyr Cys            
    1045                 1050                 1055                        

cca gga  act acg gtc acc ctg  agt gag agc tgc gga  cac cgt gga        3315
Pro Gly  Thr Thr Val Thr Leu  Ser Glu Ser Cys Gly  His Arg Gly            
    1060                 1065                 1070                        

cct gcc  act cgc acc acc aca  gag agc gga aag ttg  ata aca gat        3360
Pro Ala  Thr Arg Thr Thr Thr  Glu Ser Gly Lys Leu  Ile Thr Asp            
    1075                 1080                 1085                        

tgg tgc  tgc agg agc tgc acc  tta cca cca ctg cgc  tac caa act        3405
Trp Cys  Cys Arg Ser Cys Thr  Leu Pro Pro Leu Arg  Tyr Gln Thr            
    1090                 1095                 1100                        

gac agc  ggc tgt tgg tat ggt  atg gag atc aga cca  cag aga cat        3450
Asp Ser  Gly Cys Trp Tyr Gly  Met Glu Ile Arg Pro  Gln Arg His            
    1105                 1110                 1115                        

gat gaa  aag acc ctc gtg cag  tca caa gtg aat gct  tat aat gct        3495
Asp Glu  Lys Thr Leu Val Gln  Ser Gln Val Asn Ala  Tyr Asn Ala            
    1120                 1125                 1130                        

gat atg  att gac cct ttt cag  ttg ggc ctt ctg gtc  gtg ttc ttg        3540
Asp Met  Ile Asp Pro Phe Gln  Leu Gly Leu Leu Val  Val Phe Leu            
    1135                 1140                 1145                        

gcc acc  cag gag gtc ctt cgc  aag agg tgg aca gcc  aag atc agc        3585
Ala Thr  Gln Glu Val Leu Arg  Lys Arg Trp Thr Ala  Lys Ile Ser            
    1150                 1155                 1160                        

atg cca  gct ata ctg att gct  ctg cta gtc ctg gtg  ttt ggg ggc        3630
Met Pro  Ala Ile Leu Ile Ala  Leu Leu Val Leu Val  Phe Gly Gly            
    1165                 1170                 1175                        

att act  tac act gat gtg tta  cgc tat gtc atc ttg  gtg ggg gca        3675
Ile Thr  Tyr Thr Asp Val Leu  Arg Tyr Val Ile Leu  Val Gly Ala            
    1180                 1185                 1190                        

gct ttc  gca gaa tct aat tcg  gga gga gac gtg gta  cac ttg gcg        3720
Ala Phe  Ala Glu Ser Asn Ser  Gly Gly Asp Val Val  His Leu Ala            
    1195                 1200                 1205                        

ctc atg  gcg acc ttc aag ata  caa cca gtg ttt atg  gtg gca tcg        3765
Leu Met  Ala Thr Phe Lys Ile  Gln Pro Val Phe Met  Val Ala Ser            
    1210                 1215                 1220                        

ttt ctc  aaa gcg aga tgg acc  aac cag gag aac att  ttg ttg atg        3810
Phe Leu  Lys Ala Arg Trp Thr  Asn Gln Glu Asn Ile  Leu Leu Met            
    1225                 1230                 1235                        

ttg gcg  gct gtt ttc ttt caa  atg gct tat tac gat  gcc cgc caa        3855
Leu Ala  Ala Val Phe Phe Gln  Met Ala Tyr Tyr Asp  Ala Arg Gln            
    1240                 1245                 1250                        

att ctg  ctc tgg gag atc cct  gat gtg ttg aat tca  ctg gcg gta        3900
Ile Leu  Leu Trp Glu Ile Pro  Asp Val Leu Asn Ser  Leu Ala Val            
    1255                 1260                 1265                        

gct tgg  atg ata ctg aga gcc  ata aca ttc aca acg  aca tca aac        3945
Ala Trp  Met Ile Leu Arg Ala  Ile Thr Phe Thr Thr  Thr Ser Asn            
    1270                 1275                 1280                        

gtg gtt  gtt ccg ctg cta gcc  ctg cta aca ccc ggg  ctg aga tgc        3990
Val Val  Val Pro Leu Leu Ala  Leu Leu Thr Pro Gly  Leu Arg Cys            
    1285                 1290                 1295                        

ttg aat  ctg gat gtg tac agg  ata ctg ctg ttg atg  gtc gga ata        4035
Leu Asn  Leu Asp Val Tyr Arg  Ile Leu Leu Leu Met  Val Gly Ile            
    1300                 1305                 1310                        

ggc agc  ttg atc agg gag aag  agg agt gca gct gca  aaa aag aaa        4080
Gly Ser  Leu Ile Arg Glu Lys  Arg Ser Ala Ala Ala  Lys Lys Lys            
    1315                 1320                 1325                        

gga gca  agt ctg cta tgc ttg  gct cta gcc tca aca  gga ctt ttc        4125
Gly Ala  Ser Leu Leu Cys Leu  Ala Leu Ala Ser Thr  Gly Leu Phe            
    1330                 1335                 1340                        

aac ccc  atg atc ctt gct gct  gga ctg att gca tgt  gat ccc aac        4170
Asn Pro  Met Ile Leu Ala Ala  Gly Leu Ile Ala Cys  Asp Pro Asn            
    1345                 1350                 1355                        

cgt aaa  cgc gga tgg ccc gca  act gaa gtg atg aca  gct gtc ggc        4215
Arg Lys  Arg Gly Trp Pro Ala  Thr Glu Val Met Thr  Ala Val Gly            
    1360                 1365                 1370                        

cta atg  ttt gcc atc gtc gga  ggg ctg gca gag ctt  gac att gac        4260
Leu Met  Phe Ala Ile Val Gly  Gly Leu Ala Glu Leu  Asp Ile Asp            
    1375                 1380                 1385                        

tcc atg  gcc att cca atg act  atc gcg ggg ctc atg  ttt gct gct        4305
Ser Met  Ala Ile Pro Met Thr  Ile Ala Gly Leu Met  Phe Ala Ala            
    1390                 1395                 1400                        

ttc gtg  att tct ggg aaa tca  aca gat atg tgg att  gag aga acg        4350
Phe Val  Ile Ser Gly Lys Ser  Thr Asp Met Trp Ile  Glu Arg Thr            
    1405                 1410                 1415                        

gcg gac  att tcc tgg gaa agt  gat gca gaa att aca  ggc tcg agc        4395
Ala Asp  Ile Ser Trp Glu Ser  Asp Ala Glu Ile Thr  Gly Ser Ser            
    1420                 1425                 1430                        

gaa aga  gtt gat gtg cgg ctt  gat gat gat gga aac  ttc cag ctc        4440
Glu Arg  Val Asp Val Arg Leu  Asp Asp Asp Gly Asn  Phe Gln Leu            
    1435                 1440                 1445                        

atg aat  gat cca gga gca cct  tgg aag ata tgg atg  ctc aga atg        4485
Met Asn  Asp Pro Gly Ala Pro  Trp Lys Ile Trp Met  Leu Arg Met            
    1450                 1455                 1460                        

gtc tgt  ctc gcg att agt gcg  tac acc ccc tgg gca  atc ttg ccc        4530
Val Cys  Leu Ala Ile Ser Ala  Tyr Thr Pro Trp Ala  Ile Leu Pro            
    1465                 1470                 1475                        

tca gta  gtt gga ttt tgg ata  act ctc caa tac aca  aag aga gga        4575
Ser Val  Val Gly Phe Trp Ile  Thr Leu Gln Tyr Thr  Lys Arg Gly            
    1480                 1485                 1490                        

ggc gtg  ttg tgg gac act ccc  tca cca aag gag tac  aaa aag ggg        4620
Gly Val  Leu Trp Asp Thr Pro  Ser Pro Lys Glu Tyr  Lys Lys Gly            
    1495                 1500                 1505                        

gac acg  acc acc ggc gtc tac  agg atc atg act cgt  ggg ctg ctc        4665
Asp Thr  Thr Thr Gly Val Tyr  Arg Ile Met Thr Arg  Gly Leu Leu            
    1510                 1515                 1520                        

ggc agt  tat caa gca gga gcg  ggc gtg atg gtt gaa  ggt gtt ttc        4710
Gly Ser  Tyr Gln Ala Gly Ala  Gly Val Met Val Glu  Gly Val Phe            
    1525                 1530                 1535                        

cac acc  ctt tgg cat aca aca  aaa gga gcc gct ttg  atg agc gga        4755
His Thr  Leu Trp His Thr Thr  Lys Gly Ala Ala Leu  Met Ser Gly            
    1540                 1545                 1550                        

gag ggc  cgc ctg gac cca tac  tgg ggc agt gtc aag  gag gat cga        4800
Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Ser Val Lys  Glu Asp Arg            
    1555                 1560                 1565                        

ctt tgt  tac gga gga ccc tgg  aaa ttg cag cac aag  tgg aac ggg        4845
Leu Cys  Tyr Gly Gly Pro Trp  Lys Leu Gln His Lys  Trp Asn Gly            
    1570                 1575                 1580                        

cag gat  gag gtg cag atg att  gtg gtg gaa cct ggc  agg aac gtt        4890
Gln Asp  Glu Val Gln Met Ile  Val Val Glu Pro Gly  Arg Asn Val            
    1585                 1590                 1595                        

aag aac  gtc cag acg aaa cca  ggg gtg ttc aaa aca  cct gaa gga        4935
Lys Asn  Val Gln Thr Lys Pro  Gly Val Phe Lys Thr  Pro Glu Gly            
    1600                 1605                 1610                        

gaa atc  ggg gcc gtg act ttg  gac ttc ccc act gga  aca tca ggc        4980
Glu Ile  Gly Ala Val Thr Leu  Asp Phe Pro Thr Gly  Thr Ser Gly            
    1615                 1620                 1625                        

tca cca  ata gtg gac aaa aac  ggt gat gtg att ggg  ctt tat ggc        5025
Ser Pro  Ile Val Asp Lys Asn  Gly Asp Val Ile Gly  Leu Tyr Gly            
    1630                 1635                 1640                        

aat gga  gtc ata atg ccc aac  ggc tca tac ata agc  gcg ata gtg        5070
Asn Gly  Val Ile Met Pro Asn  Gly Ser Tyr Ile Ser  Ala Ile Val            
    1645                 1650                 1655                        

cag ggt  gaa agg atg gat gag  cca atc cca gcc gga  ttc gaa cct        5115
Gln Gly  Glu Arg Met Asp Glu  Pro Ile Pro Ala Gly  Phe Glu Pro            
    1660                 1665                 1670                        

gag atg  ctg agg aaa aaa cag  atc act gta ctg gat  ctc cat ccc        5160
Glu Met  Leu Arg Lys Lys Gln  Ile Thr Val Leu Asp  Leu His Pro            
    1675                 1680                 1685                        

ggc gcc  ggt aaa aca agg agg  att ctg cca cag atc  atc aaa gag        5205
Gly Ala  Gly Lys Thr Arg Arg  Ile Leu Pro Gln Ile  Ile Lys Glu            
    1690                 1695                 1700                        

gcc ata  aac aga aga ctg aga  aca gcc gtg cta gca  cca acc agg        5250
Ala Ile  Asn Arg Arg Leu Arg  Thr Ala Val Leu Ala  Pro Thr Arg            
    1705                 1710                 1715                        

gtt gtg  gct gct gag atg gct  gaa gca ctg aga gga  ctg ccc atc        5295
Val Val  Ala Ala Glu Met Ala  Glu Ala Leu Arg Gly  Leu Pro Ile            
    1720                 1725                 1730                        

cgg tac  cag aca tcc gca gtg  ccc aga gaa cat aat  gga aat gag        5340
Arg Tyr  Gln Thr Ser Ala Val  Pro Arg Glu His Asn  Gly Asn Glu            
    1735                 1740                 1745                        

att gtt  gat gtc atg tgt cat  gct acc ctc acc cac  agg ctg atg        5385
Ile Val  Asp Val Met Cys His  Ala Thr Leu Thr His  Arg Leu Met            
    1750                 1755                 1760                        

tct cct  cac agg gtg ccg aac  tac aac ctg ttc gtg  atg gat gag        5430
Ser Pro  His Arg Val Pro Asn  Tyr Asn Leu Phe Val  Met Asp Glu            
    1765                 1770                 1775                        

gct cat  ttc acc gac cca gct  agc att gca gca aga  ggt tac att        5475
Ala His  Phe Thr Asp Pro Ala  Ser Ile Ala Ala Arg  Gly Tyr Ile            
    1780                 1785                 1790                        

tcc aca  aag gtc gag cta ggg  gag gcg gcg gca ata  ttc atg aca        5520
Ser Thr  Lys Val Glu Leu Gly  Glu Ala Ala Ala Ile  Phe Met Thr            
    1795                 1800                 1805                        

gcc acc  cca cca ggc act tca  gat cca ttc cca gag  tcc aat tca        5565
Ala Thr  Pro Pro Gly Thr Ser  Asp Pro Phe Pro Glu  Ser Asn Ser            
    1810                 1815                 1820                        

cca att  tcc gac tta cag act  gag atc ccg gat cga  gct tgg aac        5610
Pro Ile  Ser Asp Leu Gln Thr  Glu Ile Pro Asp Arg  Ala Trp Asn            
    1825                 1830                 1835                        

tct gga  tac gaa tgg atc aca  gaa tac acc ggg aag  acg gtt tgg        5655
Ser Gly  Tyr Glu Trp Ile Thr  Glu Tyr Thr Gly Lys  Thr Val Trp            
    1840                 1845                 1850                        

ttt gtg  cct agt gtc aag atg  ggg aat gag att gcc  ctt tgc cta        5700
Phe Val  Pro Ser Val Lys Met  Gly Asn Glu Ile Ala  Leu Cys Leu            
    1855                 1860                 1865                        

caa cgt  gct gga aag aaa gta  gtc caa ttg aac aga  aag tcg tac        5745
Gln Arg  Ala Gly Lys Lys Val  Val Gln Leu Asn Arg  Lys Ser Tyr            
    1870                 1875                 1880                        

gag acg  gag tac cca aaa tgt  aag aac gat gat tgg  gac ttt gtt        5790
Glu Thr  Glu Tyr Pro Lys Cys  Lys Asn Asp Asp Trp  Asp Phe Val            
    1885                 1890                 1895                        

atc aca  aca gac ata tct gaa  atg ggg gct aac ttc  aag gcg agc        5835
Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Ser            
    1900                 1905                 1910                        

agg gtg  att gac agc cgg aag  agt gtg aaa cca acc  atc ata aca        5880
Arg Val  Ile Asp Ser Arg Lys  Ser Val Lys Pro Thr  Ile Ile Thr            
    1915                 1920                 1925                        

gaa gga  gaa ggg aga gtg atc  ctg gga gaa cca tct  gca gtg aca        5925
Glu Gly  Glu Gly Arg Val Ile  Leu Gly Glu Pro Ser  Ala Val Thr            
    1930                 1935                 1940                        

gca gct  agt gcc gcc cag aga  cgt gga cgt atc ggt  aga aat ccg        5970
Ala Ala  Ser Ala Ala Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro            
    1945                 1950                 1955                        

tcg caa  gtt ggt gat gag tac  tgt tat ggg ggg cac  acg aat gaa        6015
Ser Gln  Val Gly Asp Glu Tyr  Cys Tyr Gly Gly His  Thr Asn Glu            
    1960                 1965                 1970                        

gac gac  tcg aac ttc gcc cat  tgg act gag gca cga  atc atg ctg        6060
Asp Asp  Ser Asn Phe Ala His  Trp Thr Glu Ala Arg  Ile Met Leu            
    1975                 1980                 1985                        

gac aac  atc aac atg cca aac  gga ctg atc gct caa  ttc tac caa        6105
Asp Asn  Ile Asn Met Pro Asn  Gly Leu Ile Ala Gln  Phe Tyr Gln            
    1990                 1995                 2000                        

cca gag  cgt gag aag gta tat  acc atg gat ggg gaa  tac cgg ctc        6150
Pro Glu  Arg Glu Lys Val Tyr  Thr Met Asp Gly Glu  Tyr Arg Leu            
    2005                 2010                 2015                        

aga gga  gaa gag aga aaa aac  ttt ctg gaa ctg ttg  agg act gca        6195
Arg Gly  Glu Glu Arg Lys Asn  Phe Leu Glu Leu Leu  Arg Thr Ala            
    2020                 2025                 2030                        

gat ctg  cca gtt tgg ctg gct  tac aag gtt gca gcg  gct gga gtg        6240
Asp Leu  Pro Val Trp Leu Ala  Tyr Lys Val Ala Ala  Ala Gly Val            
    2035                 2040                 2045                        

tca tac  cac gac cgg agg tgg  tgc ttt gat ggt cct  agg aca aac        6285
Ser Tyr  His Asp Arg Arg Trp  Cys Phe Asp Gly Pro  Arg Thr Asn            
    2050                 2055                 2060                        

aca att  tta gaa gac aac aac  gaa gtg gaa gtc atc  acg aag ctt        6330
Thr Ile  Leu Glu Asp Asn Asn  Glu Val Glu Val Ile  Thr Lys Leu            
    2065                 2070                 2075                        

ggt gaa  agg aag att ctg agg  ccg cgc tgg att gac  gcc agg gtg        6375
Gly Glu  Arg Lys Ile Leu Arg  Pro Arg Trp Ile Asp  Ala Arg Val            
    2080                 2085                 2090                        

tac tcg  gat cac cag gca cta  aag gcg ttc aag gac  ttc gcc tcg        6420
Tyr Ser  Asp His Gln Ala Leu  Lys Ala Phe Lys Asp  Phe Ala Ser            
    2095                 2100                 2105                        

gga aaa  cgt tct cag ata ggg  ctc att gag gtt ctg  gga aag atg        6465
Gly Lys  Arg Ser Gln Ile Gly  Leu Ile Glu Val Leu  Gly Lys Met            
    2110                 2115                 2120                        

cct gag  cac ttc atg ggg aag  aca tgg gaa gca ctt  gac acc atg        6510
Pro Glu  His Phe Met Gly Lys  Thr Trp Glu Ala Leu  Asp Thr Met            
    2125                 2130                 2135                        

tac gtt  gtg gcc act gca gag  aaa gga gga aga gct  cac aga atg        6555
Tyr Val  Val Ala Thr Ala Glu  Lys Gly Gly Arg Ala  His Arg Met            
    2140                 2145                 2150                        

gcc ctg  gag gaa ctg cca gat  gct ctt cag aca att  gcc ttg att        6600
Ala Leu  Glu Glu Leu Pro Asp  Ala Leu Gln Thr Ile  Ala Leu Ile            
    2155                 2160                 2165                        

gcc tta  ttg agt gtg atg acc  atg gga gta ttc ttc  ctc ctc atg        6645
Ala Leu  Leu Ser Val Met Thr  Met Gly Val Phe Phe  Leu Leu Met            
    2170                 2175                 2180                        

cag cgg  aag ggc att gga aag  ata ggt ttg gga ggc  gct gtc ttg        6690
Gln Arg  Lys Gly Ile Gly Lys  Ile Gly Leu Gly Gly  Ala Val Leu            
    2185                 2190                 2195                        

gga gtc  gcg acc ttt ttc tgt  tgg atg gct gaa gtt  cca gga acg        6735
Gly Val  Ala Thr Phe Phe Cys  Trp Met Ala Glu Val  Pro Gly Thr            
    2200                 2205                 2210                        

aag atc  gcc gga atg ttg ctg  ctc tcc ctt ctc ttg  atg att gtg        6780
Lys Ile  Ala Gly Met Leu Leu  Leu Ser Leu Leu Leu  Met Ile Val            
    2215                 2220                 2225                        

cta att  cct gag cca gag aag  caa cgt tcg cag aca  gac aac cag        6825
Leu Ile  Pro Glu Pro Glu Lys  Gln Arg Ser Gln Thr  Asp Asn Gln            
    2230                 2235                 2240                        

cta gcc  gtg ttc ctg att tgt  gtc atg acc ctt gtg  agc gca gtg        6870
Leu Ala  Val Phe Leu Ile Cys  Val Met Thr Leu Val  Ser Ala Val            
    2245                 2250                 2255                        

gca gcc  aac gag atg ggt tgg  cta gat aag acc aag  agt gac ata        6915
Ala Ala  Asn Glu Met Gly Trp  Leu Asp Lys Thr Lys  Ser Asp Ile            
    2260                 2265                 2270                        

agc agt  ttg ttt ggg caa aga  att gag gtc aag gag  aat ttc agc        6960
Ser Ser  Leu Phe Gly Gln Arg  Ile Glu Val Lys Glu  Asn Phe Ser            
    2275                 2280                 2285                        

atg gga  gag ttt ctt ttg gac  ttg agg cct gca aca  gcc tgg tca        7005
Met Gly  Glu Phe Leu Leu Asp  Leu Arg Pro Ala Thr  Ala Trp Ser            
    2290                 2295                 2300                        

ctg tac  gct gtg aca aca gcg  gtc ctc act cca ctg  cta aag cat        7050
Leu Tyr  Ala Val Thr Thr Ala  Val Leu Thr Pro Leu  Leu Lys His            
    2305                 2310                 2315                        

ttg atc  acg tca gat tac atc  aac acc tca ttg acc  tca ata aac        7095
Leu Ile  Thr Ser Asp Tyr Ile  Asn Thr Ser Leu Thr  Ser Ile Asn            
    2320                 2325                 2330                        

gtt cag  gca agt gca cta ttc  aca ctc gcg cga ggc  ttc ccc ttc        7140
Val Gln  Ala Ser Ala Leu Phe  Thr Leu Ala Arg Gly  Phe Pro Phe            
    2335                 2340                 2345                        

gtc gat  gtt gga gtg tcg gct  ctc ctg cta gca gcc  gga tgc tgg        7185
Val Asp  Val Gly Val Ser Ala  Leu Leu Leu Ala Ala  Gly Cys Trp            
    2350                 2355                 2360                        

gga caa  gtc acc ctc acc gtt  acg gta aca gcg gca  aca ctc ctt        7230
Gly Gln  Val Thr Leu Thr Val  Thr Val Thr Ala Ala  Thr Leu Leu            
    2365                 2370                 2375                        

ttt tgc  cac tat gcc tac atg  gtt ccc ggt tgg caa  gct gag gca        7275
Phe Cys  His Tyr Ala Tyr Met  Val Pro Gly Trp Gln  Ala Glu Ala            
    2380                 2385                 2390                        

atg cgc  tca gcc cag cgg cgg  aca gcg gcc gga atc  atg aag aac        7320
Met Arg  Ser Ala Gln Arg Arg  Thr Ala Ala Gly Ile  Met Lys Asn            
    2395                 2400                 2405                        

gct gta  gtg gat ggc atc gtg  gcc acg gac gtc cca  gaa tta gag        7365
Ala Val  Val Asp Gly Ile Val  Ala Thr Asp Val Pro  Glu Leu Glu            
    2410                 2415                 2420                        

cgc acc  aca ccc atc atg cag  aag aaa gtt gga cag  atc atg ctg        7410
Arg Thr  Thr Pro Ile Met Gln  Lys Lys Val Gly Gln  Ile Met Leu            
    2425                 2430                 2435                        

atc ttg  gtg tct cta gct gca  gta gta gtg aac ccg  tct gtg aag        7455
Ile Leu  Val Ser Leu Ala Ala  Val Val Val Asn Pro  Ser Val Lys            
    2440                 2445                 2450                        

aca gta  cga gaa gcc gga att  ttg atc acg gcc gca  gcg gtg acg        7500
Thr Val  Arg Glu Ala Gly Ile  Leu Ile Thr Ala Ala  Ala Val Thr            
    2455                 2460                 2465                        

ctt tgg  gag aat gga gca agc  tct gtt tgg aac gca  aca act gcc        7545
Leu Trp  Glu Asn Gly Ala Ser  Ser Val Trp Asn Ala  Thr Thr Ala            
    2470                 2475                 2480                        

atc gga  ctc tgc cac atc atg  cgt ggg ggt tgg ttg  tca tgt cta        7590
Ile Gly  Leu Cys His Ile Met  Arg Gly Gly Trp Leu  Ser Cys Leu            
    2485                 2490                 2495                        

tcc ata  aca tgg aca ctc ata  aag aac atg gaa aaa  cca gga cta        7635
Ser Ile  Thr Trp Thr Leu Ile  Lys Asn Met Glu Lys  Pro Gly Leu            
    2500                 2505                 2510                        

aaa aga  ggt ggg gca aaa gga  cgc acc ttg gga gag  gtt tgg aaa        7680
Lys Arg  Gly Gly Ala Lys Gly  Arg Thr Leu Gly Glu  Val Trp Lys            
    2515                 2520                 2525                        

gaa aga  ctc aac cag atg aca  aaa gaa gag ttc act  agg tac cgc        7725
Glu Arg  Leu Asn Gln Met Thr  Lys Glu Glu Phe Thr  Arg Tyr Arg            
    2530                 2535                 2540                        

aaa gag  gcc atc atc gaa gtc  gat cgc tca gcg gca  aaa cac gcc        7770
Lys Glu  Ala Ile Ile Glu Val  Asp Arg Ser Ala Ala  Lys His Ala            
    2545                 2550                 2555                        

agg aaa  gaa ggc aat gtc act  gga ggg cat cca gtc  tct agg ggc        7815
Arg Lys  Glu Gly Asn Val Thr  Gly Gly His Pro Val  Ser Arg Gly            
    2560                 2565                 2570                        

aca gca  aaa ctg aga tgg ctg  gtc gaa cgg agg ttt  ctc gaa ccg        7860
Thr Ala  Lys Leu Arg Trp Leu  Val Glu Arg Arg Phe  Leu Glu Pro            
    2575                 2580                 2585                        

gtc gga  aaa gtg att gac ctt  gga tgt gga aga ggc  ggt tgg tgt        7905
Val Gly  Lys Val Ile Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Cys            
    2590                 2595                 2600                        

tac tat  atg gca acc caa aaa  aga gtc caa gaa gtc  aga ggg tac        7950
Tyr Tyr  Met Ala Thr Gln Lys  Arg Val Gln Glu Val  Arg Gly Tyr            
    2605                 2610                 2615                        

aca aag  ggc ggt ccc gga cat  gaa gag ccc caa cta  gtg caa agt        7995
Thr Lys  Gly Gly Pro Gly His  Glu Glu Pro Gln Leu  Val Gln Ser            
    2620                 2625                 2630                        

tat gga  tgg aac att gtc acc  atg aag agt gga gtg  gat gtg ttc        8040
Tyr Gly  Trp Asn Ile Val Thr  Met Lys Ser Gly Val  Asp Val Phe            
    2635                 2640                 2645                        

tac aga  cct tct gag tgt tgt  gac acc ctc ctt tgt  gac atc gga        8085
Tyr Arg  Pro Ser Glu Cys Cys  Asp Thr Leu Leu Cys  Asp Ile Gly            
    2650                 2655                 2660                        

gag tcc  tcg tca agt gct gag  gtt gaa gag cat agg  acg att cgg        8130
Glu Ser  Ser Ser Ser Ala Glu  Val Glu Glu His Arg  Thr Ile Arg            
    2665                 2670                 2675                        

gtc ctt  gaa atg gtt gag gac  tgg ctg cac cga ggg  cca agg gaa        8175
Val Leu  Glu Met Val Glu Asp  Trp Leu His Arg Gly  Pro Arg Glu            
    2680                 2685                 2690                        

ttt tgc  gtg aag gtg ctc tgc  ccc tac atg ccg aaa  gtc ata gag        8220
Phe Cys  Val Lys Val Leu Cys  Pro Tyr Met Pro Lys  Val Ile Glu            
    2695                 2700                 2705                        

aag atg  gag ctg ctc caa cgc  cgg tat ggg ggg gga  ctg gtc aga        8265
Lys Met  Glu Leu Leu Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg            
    2710                 2715                 2720                        

aac cca  ctc tca cgg aat tcc  acg cac gag atg tat  tgg gtg agt        8310
Asn Pro  Leu Ser Arg Asn Ser  Thr His Glu Met Tyr  Trp Val Ser            
    2725                 2730                 2735                        

cga gct  tca ggc aat gtg gta  cat tca gtg aat atg  acc agc cag        8355
Arg Ala  Ser Gly Asn Val Val  His Ser Val Asn Met  Thr Ser Gln            
    2740                 2745                 2750                        

gtg ctc  cta gga aga atg gaa  aaa agg acc tgg aag  gga ccc caa        8400
Val Leu  Leu Gly Arg Met Glu  Lys Arg Thr Trp Lys  Gly Pro Gln            
    2755                 2760                 2765                        

tac gag  gaa gat gta aac ttg  gga agt gga acc agg  gcg gtg gga        8445
Tyr Glu  Glu Asp Val Asn Leu  Gly Ser Gly Thr Arg  Ala Val Gly            
    2770                 2775                 2780                        

aaa ccc  ctg ctc aac tca gac  acc agt aaa atc aag  aac agg att        8490
Lys Pro  Leu Leu Asn Ser Asp  Thr Ser Lys Ile Lys  Asn Arg Ile            
    2785                 2790                 2795                        

gaa cga  ctc agg cgt gag tac  agt tcg acg tgg cac  cac gat gag        8535
Glu Arg  Leu Arg Arg Glu Tyr  Ser Ser Thr Trp His  His Asp Glu            
    2800                 2805                 2810                        

aac cac  cca tat aga acc tgg  aac tat cac ggc agt  tat gat gtg        8580
Asn His  Pro Tyr Arg Thr Trp  Asn Tyr His Gly Ser  Tyr Asp Val            
    2815                 2820                 2825                        

aag ccc  aca ggc tcc gcc agt  tcg ctg gtc aat gga  gtg gtc agg        8625
Lys Pro  Thr Gly Ser Ala Ser  Ser Leu Val Asn Gly  Val Val Arg            
    2830                 2835                 2840                        

ctc ctc  tca aaa cca tgg gac  acc atc acg aat gtt  acc acc atg        8670
Leu Leu  Ser Lys Pro Trp Asp  Thr Ile Thr Asn Val  Thr Thr Met            
    2845                 2850                 2855                        

gcc atg  act gac act act ccc  ttc ggg cag cag cga  gtg ttc aaa        8715
Ala Met  Thr Asp Thr Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys            
    2860                 2865                 2870                        

gag aag  gtg gac acg aaa gct  cct gaa ccg cca gaa  gga gtg aag        8760
Glu Lys  Val Asp Thr Lys Ala  Pro Glu Pro Pro Glu  Gly Val Lys            
    2875                 2880                 2885                        

tac gtg  ctc aac gag acc acc  aac tgg ttg tgg gcg  ttt ttg gcc        8805
Tyr Val  Leu Asn Glu Thr Thr  Asn Trp Leu Trp Ala  Phe Leu Ala            
    2890                 2895                 2900                        

aga gaa  aaa cgt ccc aga atg  tgc tct cga gag gaa  ttc ata aga        8850
Arg Glu  Lys Arg Pro Arg Met  Cys Ser Arg Glu Glu  Phe Ile Arg            
    2905                 2910                 2915                        

aag gtc  aac agc aat gca gct  ttg ggt gcc atg ttt  gaa gag cag        8895
Lys Val  Asn Ser Asn Ala Ala  Leu Gly Ala Met Phe  Glu Glu Gln            
    2920                 2925                 2930                        

aat caa  tgg agg agc gcc aga  gaa gca gtt gaa gat  cca aaa ttt        8940
Asn Gln  Trp Arg Ser Ala Arg  Glu Ala Val Glu Asp  Pro Lys Phe            
    2935                 2940                 2945                        

tgg gag  atg gtg gat gag gag  cgc gag gca cat ctg  cgg ggg gaa        8985
Trp Glu  Met Val Asp Glu Glu  Arg Glu Ala His Leu  Arg Gly Glu            
    2950                 2955                 2960                        

tgt cac  act tgc att tac aac  atg atg gga aag aga  gag aaa aaa        9030
Cys His  Thr Cys Ile Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys            
    2965                 2970                 2975                        

ccc gga  gag ttc gga aag gcc  aag gga agc aga gcc  att tgg ttc        9075
Pro Gly  Glu Phe Gly Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Phe            
    2980                 2985                 2990                        

atg tgg  ctc gga gct cgc ttt  ctg gag ttc gag gct  ctg ggt ttt        9120
Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe            
    2995                 3000                 3005                        

ctc aat  gaa gac cac tgg ctt  gga aga aag aac tca  gga gga ggt        9165
Leu Asn  Glu Asp His Trp Leu  Gly Arg Lys Asn Ser  Gly Gly Gly            
    3010                 3015                 3020                        

gtc gag  ggc ttg ggc ctc caa  aaa ctg ggt tac atc  ctg cgt gaa        9210
Val Glu  Gly Leu Gly Leu Gln  Lys Leu Gly Tyr Ile  Leu Arg Glu            
    3025                 3030                 3035                        

gtt ggc  acc cgg cct ggg ggc  aag atc tat gct gat  gac aca gct        9255
Val Gly  Thr Arg Pro Gly Gly  Lys Ile Tyr Ala Asp  Asp Thr Ala            
    3040                 3045                 3050                        

ggc tgg  gac acc cgc atc acg  aga gct gac ttg gaa  aat gaa gct        9300
Gly Trp  Asp Thr Arg Ile Thr  Arg Ala Asp Leu Glu  Asn Glu Ala            
    3055                 3060                 3065                        

aag gtg  ctt gag ctg ctt gat  ggg gaa cat cgg cgt  ctt gcc agg        9345
Lys Val  Leu Glu Leu Leu Asp  Gly Glu His Arg Arg  Leu Ala Arg            
    3070                 3075                 3080                        

gcc atc  att gag ctc acc tat  cgt cac aaa gtt gtg  aaa gtg atg        9390
Ala Ile  Ile Glu Leu Thr Tyr  Arg His Lys Val Val  Lys Val Met            
    3085                 3090                 3095                        

cgc ccg  gct gct gat gga aga  acc gtc atg gat gtt  atc tcc aga        9435
Arg Pro  Ala Ala Asp Gly Arg  Thr Val Met Asp Val  Ile Ser Arg            
    3100                 3105                 3110                        

gaa gat  cag agg ggg agt gga  caa gtt gtc acc tac  gcc cta aac        9480
Glu Asp  Gln Arg Gly Ser Gly  Gln Val Val Thr Tyr  Ala Leu Asn            
    3115                 3120                 3125                        

act ttc  acc aac ctg gcc gtc  cag ctg gtg agg atg  atg gaa ggg        9525
Thr Phe  Thr Asn Leu Ala Val  Gln Leu Val Arg Met  Met Glu Gly            
    3130                 3135                 3140                        

gaa gga  gtg att ggc cca gat  gat gtg gag aaa ctc  aca aaa ggg        9570
Glu Gly  Val Ile Gly Pro Asp  Asp Val Glu Lys Leu  Thr Lys Gly            
    3145                 3150                 3155                        

aaa gga  ccc aaa gtc agg acc  tgg ctg ttt gag aat  ggg gaa gaa        9615
Lys Gly  Pro Lys Val Arg Thr  Trp Leu Phe Glu Asn  Gly Glu Glu            
    3160                 3165                 3170                        

aga ctc  agc cgc atg gct gtc  agt gga gat gac tgt  gtg gta aag        9660
Arg Leu  Ser Arg Met Ala Val  Ser Gly Asp Asp Cys  Val Val Lys            
    3175                 3180                 3185                        

ccc ctg  gac gat cgc ttt gcc  acc tcg ctc cac ttc  ctc aat gct        9705
Pro Leu  Asp Asp Arg Phe Ala  Thr Ser Leu His Phe  Leu Asn Ala            
    3190                 3195                 3200                        

atg tca  aag gtt cgc aaa gac  atc caa gag tgg aaa  ccg tca act        9750
Met Ser  Lys Val Arg Lys Asp  Ile Gln Glu Trp Lys  Pro Ser Thr            
    3205                 3210                 3215                        

gga tgg  tat gat tgg cag cag  gtt cca ttt tgc tca  aac cat ttc        9795
Gly Trp  Tyr Asp Trp Gln Gln  Val Pro Phe Cys Ser  Asn His Phe            
    3220                 3225                 3230                        

act gaa  ttg atc atg aaa gat  gga aga aca ctg gtg  gtt cca tgc        9840
Thr Glu  Leu Ile Met Lys Asp  Gly Arg Thr Leu Val  Val Pro Cys            
    3235                 3240                 3245                        

cga gga  cag gat gaa ttg gta  ggc aga gct cgc ata  tct cca ggg        9885
Arg Gly  Gln Asp Glu Leu Val  Gly Arg Ala Arg Ile  Ser Pro Gly            
    3250                 3255                 3260                        

gcc gga  tgg aac gtc cgc gac  act gct tgt ctg gct  aag tct tat        9930
Ala Gly  Trp Asn Val Arg Asp  Thr Ala Cys Leu Ala  Lys Ser Tyr            
    3265                 3270                 3275                        

gcc cag  atg tgg ctg ctt ctg  tac ttc cac aga aga  gac ctg cgg        9975
Ala Gln  Met Trp Leu Leu Leu  Tyr Phe His Arg Arg  Asp Leu Arg            
    3280                 3285                 3290                        

ctc atg  gcc aac gcc att tgc  tcc gct gtc cct gtg  aat tgg gtc       10020
Leu Met  Ala Asn Ala Ile Cys  Ser Ala Val Pro Val  Asn Trp Val            
    3295                 3300                 3305                        

cct acc  gga aga acc acg tgg  tcc atc cat gca gga  gga gag tgg       10065
Pro Thr  Gly Arg Thr Thr Trp  Ser Ile His Ala Gly  Gly Glu Trp            
    3310                 3315                 3320                        

atg aca  aca gag gac atg ttg  gag gtc tgg aac cgt  gtt tgg ata       10110
Met Thr  Thr Glu Asp Met Leu  Glu Val Trp Asn Arg  Val Trp Ile            
    3325                 3330                 3335                        

gag gag  aat gaa tgg atg gaa  gac aaa acc cca gtg  gag aaa tgg       10155
Glu Glu  Asn Glu Trp Met Glu  Asp Lys Thr Pro Val  Glu Lys Trp            
    3340                 3345                 3350                        

agt gac  gtc cca tat tca gga  aaa cga gag gac atc  tgg tgt ggc       10200
Ser Asp  Val Pro Tyr Ser Gly  Lys Arg Glu Asp Ile  Trp Cys Gly            
    3355                 3360                 3365                        

agc ctg  att ggc aca aga gcc  cga gcc acg tgg gca  gaa aac atc       10245
Ser Leu  Ile Gly Thr Arg Ala  Arg Ala Thr Trp Ala  Glu Asn Ile            
    3370                 3375                 3380                        

cag gtg  gct atc aac caa gtc  aga gca atc atc gga  gat gag aag       10290
Gln Val  Ala Ile Asn Gln Val  Arg Ala Ile Ile Gly  Asp Glu Lys            
    3385                 3390                 3395                        

tat gtg  gat tac atg agt tca  cta aag aga tat gaa  gac aca act       10335
Tyr Val  Asp Tyr Met Ser Ser  Leu Lys Arg Tyr Glu  Asp Thr Thr            
    3400                 3405                 3410                        

ttg gtt  gag gac aca gta ctg  tagatattta atcaattgta aatagacaat       10386
Leu Val  Glu Asp Thr Val Leu                                              
    3415                 3420                                             

ataagtatgc ataaaagtgt agttttatag tagtatttag tggtgttagt gtaaatagtt    10446

aagaaaattt tgaggagaaa gtcaggccgg gaagttcccg ccaccggaag ttgagtagac    10506

ggtgctgcct gcgactcaac cccaggagga ctgggtgaac aaagccgcga agtgatccat    10566

gtaagccctc agaaccgtct cggaaggagg accccacatg ttgtaacttc aaagcccaat    10626

gtcagaccac gctacggcgt gctactctgc ggagagtgca gtctgcgata gtgccccagg    10686

aggactgggt taacaaaggc aaaccaacgc cccacgcggc cctagccccg gtaatggtgt    10746

taaccagggc gaaaggacta gaggttagag gagaccccgc ggtttaaagt gcacggccca    10806

gcctggctga agctgtaggt caggggaagg actagaggtt agtggagacc ccgtgccaca    10866

aaacaccaca acaaaacagc atattgacac ctgggataga ctaggagatc ttctgctctg    10926

cacaaccagc cacacggcac agtgcgccga caatggtggc tggtggtgcg agaacacagg    10986

atct                                                                 10990


<210>  6
<211>  3420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Thr Ser Leu Cys Leu Met Met 
            100                 105                 110         


Met Leu Pro Ala Thr Leu Ala Phe His Leu Thr Ser Arg Asp Gly Glu 
        115                 120                 125             


Pro Arg Met Ile Val Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe 
    130                 135                 140                 


Lys Thr Ala Ser Gly Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu 
145                 150                 155                 160 


Gly Glu Met Cys Asp Asp Thr Val Thr Tyr Lys Cys Pro His Ile Thr 
                165                 170                 175     


Glu Val Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr 
            180                 185                 190         


Trp Val Thr Tyr Gly Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp 
        195                 200                 205             


Lys Arg Ser Val Ala Leu Ala Pro His Val Gly Met Gly Leu Asp Thr 
    210                 215                 220                 


Arg Thr Gln Thr Trp Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu 
225                 230                 235                 240 


Lys Val Glu Thr Trp Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala 
                245                 250                 255     


Leu Phe Leu Ala His Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val 
            260                 265                 270         


Ile Phe Ile Leu Leu Met Leu Val Thr Pro Ser Met Thr Met Arg Cys 
        275                 280                 285             


Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr 
    290                 295                 300                 


Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr Thr Met Ala 
305                 310                 315                 320 


Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr 
                325                 330                 335     


Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn 
            340                 345                 350         


Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro 
        355                 360                 365             


Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg 
    370                 375                 380                 


Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr 
385                 390                 395                 400 


Cys Ala Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly Lys Val Val Gln 
                405                 410                 415     


His Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His Thr Gly Asp 
            420                 425                 430         


Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr 
        435                 440                 445             


Pro Gln Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu 
    450                 455                 460                 


Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile 
465                 470                 475                 480 


Ser Leu Thr Met Lys Asn Lys Ala Trp Met Val His Arg Gln Trp Phe 
                485                 490                 495     


Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Ala Glu Thr Pro 
            500                 505                 510         


Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala 
        515                 520                 525             


Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His 
    530                 535                 540                 


Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Gly Thr Ser 
545                 550                 555                 560 


Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu 
                565                 570                 575     


Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Ser Ser Phe Val Leu Lys 
            580                 585                 590         


Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu 
        595                 600                 605             


Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp 
    610                 615                 620                 


Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala Asn Pro Val 
625                 630                 635                 640 


Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe 
                645                 650                 655     


Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile 
            660                 665                 670         


Asn Trp Tyr Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr 
        675                 680                 685             


Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp 
    690                 695                 700                 


Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys Met Val His 
705                 710                 715                 720 


Gln Ile Phe Gly Ser Ala Tyr Thr Ala Leu Phe Gly Gly Val Ser Trp 
                725                 730                 735     


Met Met Lys Ile Gly Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn 
            740                 745                 750         


Ser Lys Asn Thr Ser Met Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile 
        755                 760                 765             


Thr Leu Tyr Leu Gly Ala Val Val Gln Ala Asp Ser Gly Cys Ala Ile 
    770                 775                 780                 


Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His 
785                 790                 795                 800 


Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr 
                805                 810                 815     


Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val 
            820                 825                 830         


Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala 
        835                 840                 845             


Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu 
    850                 855                 860                 


Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys 
865                 870                 875                 880 


Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp 
                885                 890                 895     


Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val 
            900                 905                 910         


Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp 
        915                 920                 925             


Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg 
    930                 935                 940                 


Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys 
945                 950                 955                 960 


Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu 
                965                 970                 975     


Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg 
            980                 985                 990         


Ala Val Leu Gly Glu Val Lys Ser  Cys Thr Trp Pro Glu  Thr His Thr 
        995                 1000                 1005             


Leu Trp  Gly Asp Gly Ile Leu  Glu Ser Asp Leu Ile  Ile Pro Val 
    1010                 1015                 1020             


Thr Leu  Ala Gly Pro Arg Ser  Asn His Asn Arg Arg  Pro Gly Tyr 
    1025                 1030                 1035             


Lys Thr  Gln Asn Gln Gly Pro  Trp Asp Glu Gly Arg  Val Glu Ile 
    1040                 1045                 1050             


Asp Phe  Asp Tyr Cys Pro Gly  Thr Thr Val Thr Leu  Ser Glu Ser 
    1055                 1060                 1065             


Cys Gly  His Arg Gly Pro Ala  Thr Arg Thr Thr Thr  Glu Ser Gly 
    1070                 1075                 1080             


Lys Leu  Ile Thr Asp Trp Cys  Cys Arg Ser Cys Thr  Leu Pro Pro 
    1085                 1090                 1095             


Leu Arg  Tyr Gln Thr Asp Ser  Gly Cys Trp Tyr Gly  Met Glu Ile 
    1100                 1105                 1110             


Arg Pro  Gln Arg His Asp Glu  Lys Thr Leu Val Gln  Ser Gln Val 
    1115                 1120                 1125             


Asn Ala  Tyr Asn Ala Asp Met  Ile Asp Pro Phe Gln  Leu Gly Leu 
    1130                 1135                 1140             


Leu Val  Val Phe Leu Ala Thr  Gln Glu Val Leu Arg  Lys Arg Trp 
    1145                 1150                 1155             


Thr Ala  Lys Ile Ser Met Pro  Ala Ile Leu Ile Ala  Leu Leu Val 
    1160                 1165                 1170             


Leu Val  Phe Gly Gly Ile Thr  Tyr Thr Asp Val Leu  Arg Tyr Val 
    1175                 1180                 1185             


Ile Leu  Val Gly Ala Ala Phe  Ala Glu Ser Asn Ser  Gly Gly Asp 
    1190                 1195                 1200             


Val Val  His Leu Ala Leu Met  Ala Thr Phe Lys Ile  Gln Pro Val 
    1205                 1210                 1215             


Phe Met  Val Ala Ser Phe Leu  Lys Ala Arg Trp Thr  Asn Gln Glu 
    1220                 1225                 1230             


Asn Ile  Leu Leu Met Leu Ala  Ala Val Phe Phe Gln  Met Ala Tyr 
    1235                 1240                 1245             


Tyr Asp  Ala Arg Gln Ile Leu  Leu Trp Glu Ile Pro  Asp Val Leu 
    1250                 1255                 1260             


Asn Ser  Leu Ala Val Ala Trp  Met Ile Leu Arg Ala  Ile Thr Phe 
    1265                 1270                 1275             


Thr Thr  Thr Ser Asn Val Val  Val Pro Leu Leu Ala  Leu Leu Thr 
    1280                 1285                 1290             


Pro Gly  Leu Arg Cys Leu Asn  Leu Asp Val Tyr Arg  Ile Leu Leu 
    1295                 1300                 1305             


Leu Met  Val Gly Ile Gly Ser  Leu Ile Arg Glu Lys  Arg Ser Ala 
    1310                 1315                 1320             


Ala Ala  Lys Lys Lys Gly Ala  Ser Leu Leu Cys Leu  Ala Leu Ala 
    1325                 1330                 1335             


Ser Thr  Gly Leu Phe Asn Pro  Met Ile Leu Ala Ala  Gly Leu Ile 
    1340                 1345                 1350             


Ala Cys  Asp Pro Asn Arg Lys  Arg Gly Trp Pro Ala  Thr Glu Val 
    1355                 1360                 1365             


Met Thr  Ala Val Gly Leu Met  Phe Ala Ile Val Gly  Gly Leu Ala 
    1370                 1375                 1380             


Glu Leu  Asp Ile Asp Ser Met  Ala Ile Pro Met Thr  Ile Ala Gly 
    1385                 1390                 1395             


Leu Met  Phe Ala Ala Phe Val  Ile Ser Gly Lys Ser  Thr Asp Met 
    1400                 1405                 1410             


Trp Ile  Glu Arg Thr Ala Asp  Ile Ser Trp Glu Ser  Asp Ala Glu 
    1415                 1420                 1425             


Ile Thr  Gly Ser Ser Glu Arg  Val Asp Val Arg Leu  Asp Asp Asp 
    1430                 1435                 1440             


Gly Asn  Phe Gln Leu Met Asn  Asp Pro Gly Ala Pro  Trp Lys Ile 
    1445                 1450                 1455             


Trp Met  Leu Arg Met Val Cys  Leu Ala Ile Ser Ala  Tyr Thr Pro 
    1460                 1465                 1470             


Trp Ala  Ile Leu Pro Ser Val  Val Gly Phe Trp Ile  Thr Leu Gln 
    1475                 1480                 1485             


Tyr Thr  Lys Arg Gly Gly Val  Leu Trp Asp Thr Pro  Ser Pro Lys 
    1490                 1495                 1500             


Glu Tyr  Lys Lys Gly Asp Thr  Thr Thr Gly Val Tyr  Arg Ile Met 
    1505                 1510                 1515             


Thr Arg  Gly Leu Leu Gly Ser  Tyr Gln Ala Gly Ala  Gly Val Met 
    1520                 1525                 1530             


Val Glu  Gly Val Phe His Thr  Leu Trp His Thr Thr  Lys Gly Ala 
    1535                 1540                 1545             


Ala Leu  Met Ser Gly Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Ser 
    1550                 1555                 1560             


Val Lys  Glu Asp Arg Leu Cys  Tyr Gly Gly Pro Trp  Lys Leu Gln 
    1565                 1570                 1575             


His Lys  Trp Asn Gly Gln Asp  Glu Val Gln Met Ile  Val Val Glu 
    1580                 1585                 1590             


Pro Gly  Arg Asn Val Lys Asn  Val Gln Thr Lys Pro  Gly Val Phe 
    1595                 1600                 1605             


Lys Thr  Pro Glu Gly Glu Ile  Gly Ala Val Thr Leu  Asp Phe Pro 
    1610                 1615                 1620             


Thr Gly  Thr Ser Gly Ser Pro  Ile Val Asp Lys Asn  Gly Asp Val 
    1625                 1630                 1635             


Ile Gly  Leu Tyr Gly Asn Gly  Val Ile Met Pro Asn  Gly Ser Tyr 
    1640                 1645                 1650             


Ile Ser  Ala Ile Val Gln Gly  Glu Arg Met Asp Glu  Pro Ile Pro 
    1655                 1660                 1665             


Ala Gly  Phe Glu Pro Glu Met  Leu Arg Lys Lys Gln  Ile Thr Val 
    1670                 1675                 1680             


Leu Asp  Leu His Pro Gly Ala  Gly Lys Thr Arg Arg  Ile Leu Pro 
    1685                 1690                 1695             


Gln Ile  Ile Lys Glu Ala Ile  Asn Arg Arg Leu Arg  Thr Ala Val 
    1700                 1705                 1710             


Leu Ala  Pro Thr Arg Val Val  Ala Ala Glu Met Ala  Glu Ala Leu 
    1715                 1720                 1725             


Arg Gly  Leu Pro Ile Arg Tyr  Gln Thr Ser Ala Val  Pro Arg Glu 
    1730                 1735                 1740             


His Asn  Gly Asn Glu Ile Val  Asp Val Met Cys His  Ala Thr Leu 
    1745                 1750                 1755             


Thr His  Arg Leu Met Ser Pro  His Arg Val Pro Asn  Tyr Asn Leu 
    1760                 1765                 1770             


Phe Val  Met Asp Glu Ala His  Phe Thr Asp Pro Ala  Ser Ile Ala 
    1775                 1780                 1785             


Ala Arg  Gly Tyr Ile Ser Thr  Lys Val Glu Leu Gly  Glu Ala Ala 
    1790                 1795                 1800             


Ala Ile  Phe Met Thr Ala Thr  Pro Pro Gly Thr Ser  Asp Pro Phe 
    1805                 1810                 1815             


Pro Glu  Ser Asn Ser Pro Ile  Ser Asp Leu Gln Thr  Glu Ile Pro 
    1820                 1825                 1830             


Asp Arg  Ala Trp Asn Ser Gly  Tyr Glu Trp Ile Thr  Glu Tyr Thr 
    1835                 1840                 1845             


Gly Lys  Thr Val Trp Phe Val  Pro Ser Val Lys Met  Gly Asn Glu 
    1850                 1855                 1860             


Ile Ala  Leu Cys Leu Gln Arg  Ala Gly Lys Lys Val  Val Gln Leu 
    1865                 1870                 1875             


Asn Arg  Lys Ser Tyr Glu Thr  Glu Tyr Pro Lys Cys  Lys Asn Asp 
    1880                 1885                 1890             


Asp Trp  Asp Phe Val Ile Thr  Thr Asp Ile Ser Glu  Met Gly Ala 
    1895                 1900                 1905             


Asn Phe  Lys Ala Ser Arg Val  Ile Asp Ser Arg Lys  Ser Val Lys 
    1910                 1915                 1920             


Pro Thr  Ile Ile Thr Glu Gly  Glu Gly Arg Val Ile  Leu Gly Glu 
    1925                 1930                 1935             


Pro Ser  Ala Val Thr Ala Ala  Ser Ala Ala Gln Arg  Arg Gly Arg 
    1940                 1945                 1950             


Ile Gly  Arg Asn Pro Ser Gln  Val Gly Asp Glu Tyr  Cys Tyr Gly 
    1955                 1960                 1965             


Gly His  Thr Asn Glu Asp Asp  Ser Asn Phe Ala His  Trp Thr Glu 
    1970                 1975                 1980             


Ala Arg  Ile Met Leu Asp Asn  Ile Asn Met Pro Asn  Gly Leu Ile 
    1985                 1990                 1995             


Ala Gln  Phe Tyr Gln Pro Glu  Arg Glu Lys Val Tyr  Thr Met Asp 
    2000                 2005                 2010             


Gly Glu  Tyr Arg Leu Arg Gly  Glu Glu Arg Lys Asn  Phe Leu Glu 
    2015                 2020                 2025             


Leu Leu  Arg Thr Ala Asp Leu  Pro Val Trp Leu Ala  Tyr Lys Val 
    2030                 2035                 2040             


Ala Ala  Ala Gly Val Ser Tyr  His Asp Arg Arg Trp  Cys Phe Asp 
    2045                 2050                 2055             


Gly Pro  Arg Thr Asn Thr Ile  Leu Glu Asp Asn Asn  Glu Val Glu 
    2060                 2065                 2070             


Val Ile  Thr Lys Leu Gly Glu  Arg Lys Ile Leu Arg  Pro Arg Trp 
    2075                 2080                 2085             


Ile Asp  Ala Arg Val Tyr Ser  Asp His Gln Ala Leu  Lys Ala Phe 
    2090                 2095                 2100             


Lys Asp  Phe Ala Ser Gly Lys  Arg Ser Gln Ile Gly  Leu Ile Glu 
    2105                 2110                 2115             


Val Leu  Gly Lys Met Pro Glu  His Phe Met Gly Lys  Thr Trp Glu 
    2120                 2125                 2130             


Ala Leu  Asp Thr Met Tyr Val  Val Ala Thr Ala Glu  Lys Gly Gly 
    2135                 2140                 2145             


Arg Ala  His Arg Met Ala Leu  Glu Glu Leu Pro Asp  Ala Leu Gln 
    2150                 2155                 2160             


Thr Ile  Ala Leu Ile Ala Leu  Leu Ser Val Met Thr  Met Gly Val 
    2165                 2170                 2175             


Phe Phe  Leu Leu Met Gln Arg  Lys Gly Ile Gly Lys  Ile Gly Leu 
    2180                 2185                 2190             


Gly Gly  Ala Val Leu Gly Val  Ala Thr Phe Phe Cys  Trp Met Ala 
    2195                 2200                 2205             


Glu Val  Pro Gly Thr Lys Ile  Ala Gly Met Leu Leu  Leu Ser Leu 
    2210                 2215                 2220             


Leu Leu  Met Ile Val Leu Ile  Pro Glu Pro Glu Lys  Gln Arg Ser 
    2225                 2230                 2235             


Gln Thr  Asp Asn Gln Leu Ala  Val Phe Leu Ile Cys  Val Met Thr 
    2240                 2245                 2250             


Leu Val  Ser Ala Val Ala Ala  Asn Glu Met Gly Trp  Leu Asp Lys 
    2255                 2260                 2265             


Thr Lys  Ser Asp Ile Ser Ser  Leu Phe Gly Gln Arg  Ile Glu Val 
    2270                 2275                 2280             


Lys Glu  Asn Phe Ser Met Gly  Glu Phe Leu Leu Asp  Leu Arg Pro 
    2285                 2290                 2295             


Ala Thr  Ala Trp Ser Leu Tyr  Ala Val Thr Thr Ala  Val Leu Thr 
    2300                 2305                 2310             


Pro Leu  Leu Lys His Leu Ile  Thr Ser Asp Tyr Ile  Asn Thr Ser 
    2315                 2320                 2325             


Leu Thr  Ser Ile Asn Val Gln  Ala Ser Ala Leu Phe  Thr Leu Ala 
    2330                 2335                 2340             


Arg Gly  Phe Pro Phe Val Asp  Val Gly Val Ser Ala  Leu Leu Leu 
    2345                 2350                 2355             


Ala Ala  Gly Cys Trp Gly Gln  Val Thr Leu Thr Val  Thr Val Thr 
    2360                 2365                 2370             


Ala Ala  Thr Leu Leu Phe Cys  His Tyr Ala Tyr Met  Val Pro Gly 
    2375                 2380                 2385             


Trp Gln  Ala Glu Ala Met Arg  Ser Ala Gln Arg Arg  Thr Ala Ala 
    2390                 2395                 2400             


Gly Ile  Met Lys Asn Ala Val  Val Asp Gly Ile Val  Ala Thr Asp 
    2405                 2410                 2415             


Val Pro  Glu Leu Glu Arg Thr  Thr Pro Ile Met Gln  Lys Lys Val 
    2420                 2425                 2430             


Gly Gln  Ile Met Leu Ile Leu  Val Ser Leu Ala Ala  Val Val Val 
    2435                 2440                 2445             


Asn Pro  Ser Val Lys Thr Val  Arg Glu Ala Gly Ile  Leu Ile Thr 
    2450                 2455                 2460             


Ala Ala  Ala Val Thr Leu Trp  Glu Asn Gly Ala Ser  Ser Val Trp 
    2465                 2470                 2475             


Asn Ala  Thr Thr Ala Ile Gly  Leu Cys His Ile Met  Arg Gly Gly 
    2480                 2485                 2490             


Trp Leu  Ser Cys Leu Ser Ile  Thr Trp Thr Leu Ile  Lys Asn Met 
    2495                 2500                 2505             


Glu Lys  Pro Gly Leu Lys Arg  Gly Gly Ala Lys Gly  Arg Thr Leu 
    2510                 2515                 2520             


Gly Glu  Val Trp Lys Glu Arg  Leu Asn Gln Met Thr  Lys Glu Glu 
    2525                 2530                 2535             


Phe Thr  Arg Tyr Arg Lys Glu  Ala Ile Ile Glu Val  Asp Arg Ser 
    2540                 2545                 2550             


Ala Ala  Lys His Ala Arg Lys  Glu Gly Asn Val Thr  Gly Gly His 
    2555                 2560                 2565             


Pro Val  Ser Arg Gly Thr Ala  Lys Leu Arg Trp Leu  Val Glu Arg 
    2570                 2575                 2580             


Arg Phe  Leu Glu Pro Val Gly  Lys Val Ile Asp Leu  Gly Cys Gly 
    2585                 2590                 2595             


Arg Gly  Gly Trp Cys Tyr Tyr  Met Ala Thr Gln Lys  Arg Val Gln 
    2600                 2605                 2610             


Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro Gly His  Glu Glu Pro 
    2615                 2620                 2625             


Gln Leu  Val Gln Ser Tyr Gly  Trp Asn Ile Val Thr  Met Lys Ser 
    2630                 2635                 2640             


Gly Val  Asp Val Phe Tyr Arg  Pro Ser Glu Cys Cys  Asp Thr Leu 
    2645                 2650                 2655             


Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser Ala Glu  Val Glu Glu 
    2660                 2665                 2670             


His Arg  Thr Ile Arg Val Leu  Glu Met Val Glu Asp  Trp Leu His 
    2675                 2680                 2685             


Arg Gly  Pro Arg Glu Phe Cys  Val Lys Val Leu Cys  Pro Tyr Met 
    2690                 2695                 2700             


Pro Lys  Val Ile Glu Lys Met  Glu Leu Leu Gln Arg  Arg Tyr Gly 
    2705                 2710                 2715             


Gly Gly  Leu Val Arg Asn Pro  Leu Ser Arg Asn Ser  Thr His Glu 
    2720                 2725                 2730             


Met Tyr  Trp Val Ser Arg Ala  Ser Gly Asn Val Val  His Ser Val 
    2735                 2740                 2745             


Asn Met  Thr Ser Gln Val Leu  Leu Gly Arg Met Glu  Lys Arg Thr 
    2750                 2755                 2760             


Trp Lys  Gly Pro Gln Tyr Glu  Glu Asp Val Asn Leu  Gly Ser Gly 
    2765                 2770                 2775             


Thr Arg  Ala Val Gly Lys Pro  Leu Leu Asn Ser Asp  Thr Ser Lys 
    2780                 2785                 2790             


Ile Lys  Asn Arg Ile Glu Arg  Leu Arg Arg Glu Tyr  Ser Ser Thr 
    2795                 2800                 2805             


Trp His  His Asp Glu Asn His  Pro Tyr Arg Thr Trp  Asn Tyr His 
    2810                 2815                 2820             


Gly Ser  Tyr Asp Val Lys Pro  Thr Gly Ser Ala Ser  Ser Leu Val 
    2825                 2830                 2835             


Asn Gly  Val Val Arg Leu Leu  Ser Lys Pro Trp Asp  Thr Ile Thr 
    2840                 2845                 2850             


Asn Val  Thr Thr Met Ala Met  Thr Asp Thr Thr Pro  Phe Gly Gln 
    2855                 2860                 2865             


Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr Lys Ala  Pro Glu Pro 
    2870                 2875                 2880             


Pro Glu  Gly Val Lys Tyr Val  Leu Asn Glu Thr Thr  Asn Trp Leu 
    2885                 2890                 2895             


Trp Ala  Phe Leu Ala Arg Glu  Lys Arg Pro Arg Met  Cys Ser Arg 
    2900                 2905                 2910             


Glu Glu  Phe Ile Arg Lys Val  Asn Ser Asn Ala Ala  Leu Gly Ala 
    2915                 2920                 2925             


Met Phe  Glu Glu Gln Asn Gln  Trp Arg Ser Ala Arg  Glu Ala Val 
    2930                 2935                 2940             


Glu Asp  Pro Lys Phe Trp Glu  Met Val Asp Glu Glu  Arg Glu Ala 
    2945                 2950                 2955             


His Leu  Arg Gly Glu Cys His  Thr Cys Ile Tyr Asn  Met Met Gly 
    2960                 2965                 2970             


Lys Arg  Glu Lys Lys Pro Gly  Glu Phe Gly Lys Ala  Lys Gly Ser 
    2975                 2980                 2985             


Arg Ala  Ile Trp Phe Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe 
    2990                 2995                 3000             


Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His Trp Leu  Gly Arg Lys 
    3005                 3010                 3015             


Asn Ser  Gly Gly Gly Val Glu  Gly Leu Gly Leu Gln  Lys Leu Gly 
    3020                 3025                 3030             


Tyr Ile  Leu Arg Glu Val Gly  Thr Arg Pro Gly Gly  Lys Ile Tyr 
    3035                 3040                 3045             


Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg Ile Thr  Arg Ala Asp 
    3050                 3055                 3060             


Leu Glu  Asn Glu Ala Lys Val  Leu Glu Leu Leu Asp  Gly Glu His 
    3065                 3070                 3075             


Arg Arg  Leu Ala Arg Ala Ile  Ile Glu Leu Thr Tyr  Arg His Lys 
    3080                 3085                 3090             


Val Val  Lys Val Met Arg Pro  Ala Ala Asp Gly Arg  Thr Val Met 
    3095                 3100                 3105             


Asp Val  Ile Ser Arg Glu Asp  Gln Arg Gly Ser Gly  Gln Val Val 
    3110                 3115                 3120             


Thr Tyr  Ala Leu Asn Thr Phe  Thr Asn Leu Ala Val  Gln Leu Val 
    3125                 3130                 3135             


Arg Met  Met Glu Gly Glu Gly  Val Ile Gly Pro Asp  Asp Val Glu 
    3140                 3145                 3150             


Lys Leu  Thr Lys Gly Lys Gly  Pro Lys Val Arg Thr  Trp Leu Phe 
    3155                 3160                 3165             


Glu Asn  Gly Glu Glu Arg Leu  Ser Arg Met Ala Val  Ser Gly Asp 
    3170                 3175                 3180             


Asp Cys  Val Val Lys Pro Leu  Asp Asp Arg Phe Ala  Thr Ser Leu 
    3185                 3190                 3195             


His Phe  Leu Asn Ala Met Ser  Lys Val Arg Lys Asp  Ile Gln Glu 
    3200                 3205                 3210             


Trp Lys  Pro Ser Thr Gly Trp  Tyr Asp Trp Gln Gln  Val Pro Phe 
    3215                 3220                 3225             


Cys Ser  Asn His Phe Thr Glu  Leu Ile Met Lys Asp  Gly Arg Thr 
    3230                 3235                 3240             


Leu Val  Val Pro Cys Arg Gly  Gln Asp Glu Leu Val  Gly Arg Ala 
    3245                 3250                 3255             


Arg Ile  Ser Pro Gly Ala Gly  Trp Asn Val Arg Asp  Thr Ala Cys 
    3260                 3265                 3270             


Leu Ala  Lys Ser Tyr Ala Gln  Met Trp Leu Leu Leu  Tyr Phe His 
    3275                 3280                 3285             


Arg Arg  Asp Leu Arg Leu Met  Ala Asn Ala Ile Cys  Ser Ala Val 
    3290                 3295                 3300             


Pro Val  Asn Trp Val Pro Thr  Gly Arg Thr Thr Trp  Ser Ile His 
    3305                 3310                 3315             


Ala Gly  Gly Glu Trp Met Thr  Thr Glu Asp Met Leu  Glu Val Trp 
    3320                 3325                 3330             


Asn Arg  Val Trp Ile Glu Glu  Asn Glu Trp Met Glu  Asp Lys Thr 
    3335                 3340                 3345             


Pro Val  Glu Lys Trp Ser Asp  Val Pro Tyr Ser Gly  Lys Arg Glu 
    3350                 3355                 3360             


Asp Ile  Trp Cys Gly Ser Leu  Ile Gly Thr Arg Ala  Arg Ala Thr 
    3365                 3370                 3375             


Trp Ala  Glu Asn Ile Gln Val  Ala Ile Asn Gln Val  Arg Ala Ile 
    3380                 3385                 3390             


Ile Gly  Asp Glu Lys Tyr Val  Asp Tyr Met Ser Ser  Leu Lys Arg 
    3395                 3400                 3405             


Tyr Glu  Asp Thr Thr Leu Val  Glu Asp Thr Val Leu  
    3410                 3415                 3420 


<210>  7
<211>  10996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant West Nile virus/Dengue-4 virus chimera


<220>
<221>  CDS
<222>  (97)..(10362)

<400>  7
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agc tca aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga tca acg ata aca ttg ctg tgc ttg att ccc acc gta atg        450
Lys Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu Ile Pro Thr Val Met           
        105                 110                 115                       

gcg ttt cac ttg tca aca aga gat ggc gaa ccc ctc atg ata gtg gca        498
Ala Phe His Leu Ser Thr Arg Asp Gly Glu Pro Leu Met Ile Val Ala           
    120                 125                 130                           

aaa cat gaa agg ggg aga cct ctc ctg ttt aag aca aca gag ggg atc        546
Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly Ile           
135                 140                 145                 150           

aac aaa tgc act ctc att gcc atg gac ttg ggt gaa atg tgt gag gac        594
Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Glu Asp           
                155                 160                 165               

act gtc acg tac aaa tgc ccc tta ctg gtc aat acc gaa cct gaa gac        642
Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu Asp           
            170                 175                 180                   

att gat tgc tgg tgc aat ctc acg tct acc tgg gtc atg tat ggg aca        690
Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr Gly Thr           
        185                 190                 195                       

tgc acc cag agc gga gaa cgg aga cga gag aag cgc tca gta gct tta        738
Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala Leu           
    200                 205                 210                           

aca cca cat tca gga atg gga ttg gaa aca aga gct gag aca tgg atg        786
Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp Met           
215                 220                 225                 230           

tca tcg gaa ggg gct tgg aag cat gct cag aga gta gag agc tgg ata        834
Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp Ile           
                235                 240                 245               

ctc aga aac cca gga ttc gcg ctc ttg gca gga ttt atg gct tat atg        882
Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr Met           
            250                 255                 260                   

att ggg caa aca gga atc cag cga act gtc ttc ttt gtc cta atg atg        930
Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu Met Met           
        265                 270                 275                       

ctg gtc gcc cca tcc tac gga atg cga tgc gta gga gta ggg aac aga        978
Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly Val Gly Asn Arg           
    280                 285                 290                           

gac ttt gtg gaa gga gtc tca ggt gga gca tgg gtc gat ctg gtg cta       1026
Asp Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val Leu           
295                 300                 305                 310           

gaa cat gga gga tgc gtc aca acc atg gcc cag gga aaa cca acc ttg       1074
Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr Leu           
                315                 320                 325               

gat ttt gaa ctg act aag aca aca gcc aag gaa gtg gct ctg tta aga       1122
Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu Leu Arg           
            330                 335                 340                   

acc tat tgc att gaa gcc tca ata tca aac ata acc acg gca aca aga       1170
Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr Arg           
        345                 350                 355                       

tgt cca acg caa gga gag cct tat cta aaa gag gaa caa gac caa cag       1218
Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln Gln           
    360                 365                 370                           

tac att tgc cgg aga gat gtg gta gac aga ggg tgg ggc aat ggc tgt       1266
Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly Cys           
375                 380                 385                 390           

ggc ttg ttt gga aaa gga gga gtt gtg aca tgt gcg aag ttt tca tgt       1314
Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe Ser Cys           
                395                 400                 405               

tcg ggg aag ata aca ggc aat ttg gtc caa att gag aac ctt gaa tac       1362
Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu Tyr           
            410                 415                 420                   

aca gtg gtt gta aca gtc cac aat gga gac acc cat gca gta gga aat       1410
Thr Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly Asn           
        425                 430                 435                       

gac aca tcc aat cat gga gtt aca gcc acg ata act ccc agg tca cca       1458
Asp Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg Ser Pro           
    440                 445                 450                           

tcg gtg gaa gtc aaa ttg ccg gac tat gga gaa cta aca ctc gat tgt       1506
Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp Cys           
455                 460                 465                 470           

gaa ccc agg tct gga att gac ttt aat gag atg att ctg atg aaa atg       1554
Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys Met           
                475                 480                 485               

aaa aag aaa aca tgg ctt gtg cat aag caa tgg ttt ttg gat cta cct       1602
Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu Pro           
            490                 495                 500                   

cta cca tgg aca gca gga gca gac aca tca gag gtt cac tgg aat tac       1650
Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn Tyr           
        505                 510                 515                       

aaa gag aga atg gtg aca ttt aag gtt cct cat gcc aag aga cag gat       1698
Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg Gln Asp           
    520                 525                 530                           

gtg aca gtg ctg gga tct cag gaa gga gcc atg cat tct gcc ctc gct       1746
Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu Ala           
535                 540                 545                 550           

gga gcc aca gaa gtg gac tcc ggt gat gga aat cac atg ttt gca gga       1794
Gly Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala Gly           
                555                 560                 565               

cat ctc aag tgc aaa gtc cgt atg gag aaa ttg aga atc aag gga atg       1842
His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly Met           
            570                 575                 580                   

tca tac acg atg tgt tca gga aag ttc tca att gac aaa gag atg gca       1890
Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met Ala           
        585                 590                 595                       

gaa aca cag cat ggg aca aca gtg gtg aaa gtc aag tat gaa ggt gct       1938
Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly Ala           
    600                 605                 610                           

gga gct ccg tgt aaa gtc ccc ata gag ata aga gat gtg aac aag gaa       1986
Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys Glu           
615                 620                 625                 630           

aaa gtg gtt ggg cgt atc atc tca tcc acc cct ttg gct gag aat acc       2034
Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu Asn Thr           
                635                 640                 645               

aac agt gca acc aac ata gag tta gaa ccc ccc ttt ggg gac agc tac       2082
Asn Ser Ala Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr           
            650                 655                 660                   

ata gtg ata ggt gtt gga aac agt gca tta aca ctc cat tgg ttc agg       2130
Ile Val Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe Arg           
        665                 670                 675                       

aaa ggg agt tcc att ggc aag atg ttt gag tcc aca tac aga ggt gca       2178
Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly Ala           
    680                 685                 690                           

aaa cga atg gcc att cta ggt gaa aca gct tgg gat ttt ggt tcc gtt       2226
Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser Val           
695                 700                 705                 710           

ggt gga ctg ttc aca tca ttg gga aag gct gtg cac cag gtt ttt gga       2274
Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe Gly           
                715                 720                 725               

agt gtg tat aca acc atg ttt gga gga gtc tca tgg atg att aga atc       2322
Ser Val Tyr Thr Thr Met Phe Gly Gly Val Ser Trp Met Ile Arg Ile           
            730                 735                 740                   

cta att ggg ttc cta gtg ttg tgg att ggc acg aac tca agg aac act       2370
Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn Thr           
        745                 750                 755                       

tca atg gct atg acg tgc ata gct gtt gga gga atc act ctg ttt ctg       2418
Ser Met Ala Met Thr Cys Ile Ala Val Gly Gly Ile Thr Leu Phe Leu           
    760                 765                 770                           

ggc ttc aca gtt caa gca gac tcc gga tgt gcc ata gac atc agc cgg       2466
Gly Phe Thr Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile Ser Arg           
775                 780                 785                 790           

caa gag ctg aga tgt gga agt gga gtg ttc ata cac aat gat gtg gag       2514
Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val Glu           
                795                 800                 805               

gct tgg atg gac cgg tac aag tat tac cct gaa acg cca caa ggc cta       2562
Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly Leu           
            810                 815                 820                   

gcc aag atc att cag aaa gct cat aag gaa gga gtg tgc ggt cta cga       2610
Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu Arg           
        825                 830                 835                       

tca gtt tcc aga ctg gag cat caa atg tgg gaa gca gtg aag gac gag       2658
Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp Glu           
    840                 845                 850                           

ctg aac act ctt ttg aag gag aat ggt gtg gac ctt agt gtc gtg gtt       2706
Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val Val           
855                 860                 865                 870           

gag aaa cag gag gga atg tac aag tca gca cct aaa cgc ctc acc gcc       2754
Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr Ala           
                875                 880                 885               

acc acg gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag agt att       2802
Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser Ile           
            890                 895                 900                   

tta ttt gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat ggt ccg       2850
Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly Pro           
        905                 910                 915                       

gag acc aag gaa tgt ccg act cag aat cgc gct tgg aat agc tta gaa       2898
Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu Glu           
    920                 925                 930                           

gtg gag gat ttt gga ttt ggt ctc acc agc act cgg atg ttc ctg aag       2946
Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu Lys           
935                 940                 945                 950           

gtc aga gag agc aac aca act gaa tgt gac tcg aag atc att gga acg       2994
Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly Thr           
                955                 960                 965               

gct gtc aag aac aac ttg gcg atc cac agt gac ctg tcc tat tgg att       3042
Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp Ile           
            970                 975                 980                   

gaa agc agg ctc aat gat acg tgg aag ctt gaa agg gca gtt ctg ggt       3090
Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val Leu Gly           
        985                 990                 995                       

gaa gtc  aaa tca tgt acg tgg  cct gag acg cat acc  ttg tgg ggc        3135
Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr His Thr  Leu Trp Gly            
    1000                 1005                 1010                        

gat gga  atc ctt gag agt gac  ttg ata ata cca gtc  aca ctg gcg        3180
Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile Pro Val  Thr Leu Ala            
    1015                 1020                 1025                        

gga cca  cga agc aat cac aat  cgg aga cct ggg tac  aag aca caa        3225
Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro Gly Tyr  Lys Thr Gln            
    1030                 1035                 1040                        

aac cag  ggc cca tgg gac gaa  ggc cgg gta gag att  gac ttc gat        3270
Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val Glu Ile  Asp Phe Asp            
    1045                 1050                 1055                        

tac tgc  cca gga act acg gtc  acc ctg agt gag agc  tgc gga cac        3315
Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser Glu Ser  Cys Gly His            
    1060                 1065                 1070                        

cgt gga  cct gcc act cgc acc  acc aca gag agc gga  aag ttg ata        3360
Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu Ser Gly  Lys Leu Ile            
    1075                 1080                 1085                        

aca gat  tgg tgc tgc agg agc  tgc acc tta cca cca  ctg cgc tac        3405
Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr            
    1090                 1095                 1100                        

caa act  gac agc ggc tgt tgg  tat ggt atg gag atc  aga cca cag        3450
Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Gln            
    1105                 1110                 1115                        

aga cat  gat gaa aag acc ctc  gtg cag tca caa gtg  aat gct tat        3495
Arg His  Asp Glu Lys Thr Leu  Val Gln Ser Gln Val  Asn Ala Tyr            
    1120                 1125                 1130                        

aat gct  gat atg att gac cct  ttt cag ttg ggc ctt  ctg gtc gtg        3540
Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu Gly Leu  Leu Val Val            
    1135                 1140                 1145                        

ttc ttg  gcc acc cag gag gtc  ctt cgc aag agg tgg  aca gcc aag        3585
Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys Arg Trp  Thr Ala Lys            
    1150                 1155                 1160                        

atc agc  atg cca gct ata ctg  att gct ctg cta gtc  ctg gtg ttt        3630
Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu Leu Val  Leu Val Phe            
    1165                 1170                 1175                        

ggg ggc  att act tac act gat  gtg tta cgc tat gtc  atc ttg gtg        3675
Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg Tyr Val  Ile Leu Val            
    1180                 1185                 1190                        

ggg gca  gct ttc gca gaa tct  aat tcg gga gga gac  gtg gta cac        3720
Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly Gly Asp  Val Val His            
    1195                 1200                 1205                        

ttg gcg  ctc atg gcg acc ttc  aag ata caa cca gtg  ttt atg gtg        3765
Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln Pro Val  Phe Met Val            
    1210                 1215                 1220                        

gca tcg  ttt ctc aaa gcg aga  tgg acc aac cag gag  aac att ttg        3810
Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn Gln Glu  Asn Ile Leu            
    1225                 1230                 1235                        

ttg atg  ttg gcg gct gtt ttc  ttt caa atg gct tat  tac gat gcc        3855
Leu Met  Leu Ala Ala Val Phe  Phe Gln Met Ala Tyr  Tyr Asp Ala            
    1240                 1245                 1250                        

cgc caa  att ctg ctc tgg gag  atc cct gat gtg ttg  aat tca ctg        3900
Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp Val Leu  Asn Ser Leu            
    1255                 1260                 1265                        

gcg gta  gct tgg atg ata ctg  aga gcc ata aca ttc  aca acg aca        3945
Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile Thr Phe  Thr Thr Thr            
    1270                 1275                 1280                        

tca aac  gtg gtt gtt ccg ctg  cta gcc ctg cta aca  ccc ggg ctg        3990
Ser Asn  Val Val Val Pro Leu  Leu Ala Leu Leu Thr  Pro Gly Leu            
    1285                 1290                 1295                        

aga tgc  ttg aat ctg gat gtg  tac agg ata ctg ctg  ttg atg gtc        4035
Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile Leu Leu  Leu Met Val            
    1300                 1305                 1310                        

gga ata  ggc agc ttg atc agg  gag aag agg agt gca  gct gca aaa        4080
Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg Ser Ala  Ala Ala Lys            
    1315                 1320                 1325                        

aag aaa  gga gca agt ctg cta  tgc ttg gct cta gcc  tca aca gga        4125
Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala Leu Ala  Ser Thr Gly            
    1330                 1335                 1340                        

ctt ttc  aac ccc atg atc ctt  gct gct gga ctg att  gca tgt gat        4170
Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly Leu Ile  Ala Cys Asp            
    1345                 1350                 1355                        

ccc aac  cgt aaa cgc gga tgg  ccc gca act gaa gtg  atg aca gct        4215
Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr Glu Val  Met Thr Ala            
    1360                 1365                 1370                        

gtc ggc  cta atg ttt gcc atc  gtc gga ggg ctg gca  gag ctt gac        4260
Val Gly  Leu Met Phe Ala Ile  Val Gly Gly Leu Ala  Glu Leu Asp            
    1375                 1380                 1385                        

att gac  tcc atg gcc att cca  atg act atc gcg ggg  ctc atg ttt        4305
Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile Ala Gly  Leu Met Phe            
    1390                 1395                 1400                        

gct gct  ttc gtg att tct ggg  aaa tca aca gat atg  tgg att gag        4350
Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr Asp Met  Trp Ile Glu            
    1405                 1410                 1415                        

aga acg  gcg gac att tcc tgg  gaa agt gat gca gaa  att aca ggc        4395
Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp Ala Glu  Ile Thr Gly            
    1420                 1425                 1430                        

tcg agc  gaa aga gtt gat gtg  cgg ctt gat gat gat  gga aac ttc        4440
Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp Asp Asp  Gly Asn Phe            
    1435                 1440                 1445                        

cag ctc  atg aat gat cca gga  gca cct tgg aag ata  tgg atg ctc        4485
Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp Lys Ile  Trp Met Leu            
    1450                 1455                 1460                        

aga atg  gtc tgt ctc gcg att  agt gcg tac acc ccc  tgg gca atc        4530
Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr Thr Pro  Trp Ala Ile            
    1465                 1470                 1475                        

ttg ccc  tca gta gtt gga ttt  tgg ata act ctc caa  tac aca aag        4575
Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr Leu Gln  Tyr Thr Lys            
    1480                 1485                 1490                        

aga gga  ggc gtg ttg tgg gac  act ccc tca cca aag  gag tac aaa        4620
Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser Pro Lys  Glu Tyr Lys            
    1495                 1500                 1505                        

aag ggg  gac acg acc acc ggc  gtc tac agg atc atg  act cgt ggg        4665
Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg Ile Met  Thr Arg Gly            
    1510                 1515                 1520                        

ctg ctc  ggc agt tat caa gca  gga gcg ggc gtg atg  gtt gaa ggt        4710
Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly Val Met  Val Glu Gly            
    1525                 1530                 1535                        

gtt ttc  cac acc ctt tgg cat  aca aca aaa gga gcc  gct ttg atg        4755
Val Phe  His Thr Leu Trp His  Thr Thr Lys Gly Ala  Ala Leu Met            
    1540                 1545                 1550                        

agc gga  gag ggc cgc ctg gac  cca tac tgg ggc agt  gtc aag gag        4800
Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp Gly Ser  Val Lys Glu            
    1555                 1560                 1565                        

gat cga  ctt tgt tac gga gga  ccc tgg aaa ttg cag  cac aag tgg        4845
Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys Leu Gln  His Lys Trp            
    1570                 1575                 1580                        

aac ggg  cag gat gag gtg cag  atg att gtg gtg gaa  cct ggc agg        4890
Asn Gly  Gln Asp Glu Val Gln  Met Ile Val Val Glu  Pro Gly Arg            
    1585                 1590                 1595                        

aac gtt  aag aac gtc cag acg  aaa cca ggg gtg ttc  aaa aca cct        4935
Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly Val Phe  Lys Thr Pro            
    1600                 1605                 1610                        

gaa gga  gaa atc ggg gcc gtg  act ttg gac ttc ccc  act gga aca        4980
Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp Phe Pro  Thr Gly Thr            
    1615                 1620                 1625                        

tca ggc  tca cca ata gtg gac  aaa aac ggt gat gtg  att ggg ctt        5025
Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly Asp Val  Ile Gly Leu            
    1630                 1635                 1640                        

tat ggc  aat gga gtc ata atg  ccc aac ggc tca tac  ata agc gcg        5070
Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly Ser Tyr  Ile Ser Ala            
    1645                 1650                 1655                        

ata gtg  cag ggt gaa agg atg  gat gag cca atc cca  gcc gga ttc        5115
Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro Ile Pro  Ala Gly Phe            
    1660                 1665                 1670                        

gaa cct  gag atg ctg agg aaa  aaa cag atc act gta  ctg gat ctc        5160
Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile Thr Val  Leu Asp Leu            
    1675                 1680                 1685                        

cat ccc  ggc gcc ggt aaa aca  agg agg att ctg cca  cag atc atc        5205
His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile Leu Pro  Gln Ile Ile            
    1690                 1695                 1700                        

aaa gag  gcc ata aac aga aga  ctg aga aca gcc gtg  cta gca cca        5250
Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr Ala Val  Leu Ala Pro            
    1705                 1710                 1715                        

acc agg  gtt gtg gct gct gag  atg gct gaa gca ctg  aga gga ctg        5295
Thr Arg  Val Val Ala Ala Glu  Met Ala Glu Ala Leu  Arg Gly Leu            
    1720                 1725                 1730                        

ccc atc  cgg tac cag aca tcc  gca gtg ccc aga gaa  cat aat gga        5340
Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro Arg Glu  His Asn Gly            
    1735                 1740                 1745                        

aat gag  att gtt gat gtc atg  tgt cat gct acc ctc  acc cac agg        5385
Asn Glu  Ile Val Asp Val Met  Cys His Ala Thr Leu  Thr His Arg            
    1750                 1755                 1760                        

ctg atg  tct cct cac agg gtg  ccg aac tac aac ctg  ttc gtg atg        5430
Leu Met  Ser Pro His Arg Val  Pro Asn Tyr Asn Leu  Phe Val Met            
    1765                 1770                 1775                        

gat gag  gct cat ttc acc gac  cca gct agc att gca  gca aga ggt        5475
Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly            
    1780                 1785                 1790                        

tac att  tcc aca aag gtc gag  cta ggg gag gcg gcg  gca ata ttc        5520
Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu Ala Ala  Ala Ile Phe            
    1795                 1800                 1805                        

atg aca  gcc acc cca cca ggc  act tca gat cca ttc  cca gag tcc        5565
Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp Pro Phe  Pro Glu Ser            
    1810                 1815                 1820                        

aat tca  cca att tcc gac tta  cag act gag atc ccg  gat cga gct        5610
Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu Ile Pro  Asp Arg Ala            
    1825                 1830                 1835                        

tgg aac  tct gga tac gaa tgg  atc aca gaa tac acc  ggg aag acg        5655
Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu Tyr Thr  Gly Lys Thr            
    1840                 1845                 1850                        

gtt tgg  ttt gtg cct agt gtc  aag atg ggg aat gag  att gcc ctt        5700
Val Trp  Phe Val Pro Ser Val  Lys Met Gly Asn Glu  Ile Ala Leu            
    1855                 1860                 1865                        

tgc cta  caa cgt gct gga aag  aaa gta gtc caa ttg  aac aga aag        5745
Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val Gln Leu  Asn Arg Lys            
    1870                 1875                 1880                        

tcg tac  gag acg gag tac cca  aaa tgt aag aac gat  gat tgg gac        5790
Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys Asn Asp  Asp Trp Asp            
    1885                 1890                 1895                        

ttt gtt  atc aca aca gac ata  tct gaa atg ggg gct  aac ttc aag        5835
Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys            
    1900                 1905                 1910                        

gcg agc  agg gtg att gac agc  cgg aag agt gtg aaa  cca acc atc        5880
Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser Val Lys  Pro Thr Ile            
    1915                 1920                 1925                        

ata aca  gaa gga gaa ggg aga  gtg atc ctg gga gaa  cca tct gca        5925
Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu Gly Glu  Pro Ser Ala            
    1930                 1935                 1940                        

gtg aca  gca gct agt gcc gcc  cag aga cgt gga cgt  atc ggt aga        5970
Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg            
    1945                 1950                 1955                        

aat ccg  tcg caa gtt ggt gat  gag tac tgt tat ggg  ggg cac acg        6015
Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys Tyr Gly  Gly His Thr            
    1960                 1965                 1970                        

aat gaa  gac gac tcg aac ttc  gcc cat tgg act gag  gca cga atc        6060
Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp Thr Glu  Ala Arg Ile            
    1975                 1980                 1985                        

atg ctg  gac aac atc aac atg  cca aac gga ctg atc  gct caa ttc        6105
Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly Leu Ile  Ala Gln Phe            
    1990                 1995                 2000                        

tac caa  cca gag cgt gag aag  gta tat acc atg gat  ggg gaa tac        6150
Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr Met Asp  Gly Glu Tyr            
    2005                 2010                 2015                        

cgg ctc  aga gga gaa gag aga  aaa aac ttt ctg gaa  ctg ttg agg        6195
Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe Leu Glu  Leu Leu Arg            
    2020                 2025                 2030                        

act gca  gat ctg cca gtt tgg  ctg gct tac aag gtt  gca gcg gct        6240
Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr Lys Val  Ala Ala Ala            
    2035                 2040                 2045                        

gga gtg  tca tac cac gac cgg  agg tgg tgc ttt gat  ggt cct agg        6285
Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys Phe Asp  Gly Pro Arg            
    2050                 2055                 2060                        

aca aac  aca att tta gaa gac  aac aac gaa gtg gaa  gtc atc acg        6330
Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu Val Glu  Val Ile Thr            
    2065                 2070                 2075                        

aag ctt  ggt gaa agg aag att  ctg agg ccg cgc tgg  att gac gcc        6375
Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro Arg Trp  Ile Asp Ala            
    2080                 2085                 2090                        

agg gtg  tac tcg gat cac cag  gca cta aag gcg ttc  aag gac ttc        6420
Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys Ala Phe  Lys Asp Phe            
    2095                 2100                 2105                        

gcc tcg  gga aaa cgt tct cag  ata ggg ctc att gag  gtt ctg gga        6465
Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu Ile Glu  Val Leu Gly            
    2110                 2115                 2120                        

aag atg  cct gag cac ttc atg  ggg aag aca tgg gaa  gca ctt gac        6510
Lys Met  Pro Glu His Phe Met  Gly Lys Thr Trp Glu  Ala Leu Asp            
    2125                 2130                 2135                        

acc atg  tac gtt gtg gcc act  gca gag aaa gga gga  aga gct cac        6555
Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys Gly Gly  Arg Ala His            
    2140                 2145                 2150                        

aga atg  gcc ctg gag gaa ctg  cca gat gct ctt cag  aca att gcc        6600
Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala Leu Gln  Thr Ile Ala            
    2155                 2160                 2165                        

ttg att  gcc tta ttg agt gtg  atg acc atg gga gta  ttc ttc ctc        6645
Leu Ile  Ala Leu Leu Ser Val  Met Thr Met Gly Val  Phe Phe Leu            
    2170                 2175                 2180                        

ctc atg  cag cgg aag ggc att  gga aag ata ggt ttg  gga ggc gct        6690
Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile Gly Leu  Gly Gly Ala            
    2185                 2190                 2195                        

gtc ttg  gga gtc gcg acc ttt  ttc tgt tgg atg gct  gaa gtt cca        6735
Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp Met Ala  Glu Val Pro            
    2200                 2205                 2210                        

gga acg  aag atc gcc gga atg  ttg ctg ctc tcc ctt  ctc ttg atg        6780
Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu Ser Leu  Leu Leu Met            
    2215                 2220                 2225                        

att gtg  cta att cct gag cca  gag aag caa cgt tcg  cag aca gac        6825
Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Ser  Gln Thr Asp            
    2230                 2235                 2240                        

aac cag  cta gcc gtg ttc ctg  att tgt gtc atg acc  ctt gtg agc        6870
Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val Met Thr  Leu Val Ser            
    2245                 2250                 2255                        

gca gtg  gca gcc aac gag atg  ggt tgg cta gat aag  acc aag agt        6915
Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu Asp Lys  Thr Lys Ser            
    2260                 2265                 2270                        

gac ata  agc agt ttg ttt ggg  caa aga att gag gtc  aag gag aat        6960
Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile Glu Val  Lys Glu Asn            
    2275                 2280                 2285                        

ttc agc  atg gga gag ttt ctt  ttg gac ttg agg cct  gca aca gcc        7005
Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu Arg Pro  Ala Thr Ala            
    2290                 2295                 2300                        

tgg tca  ctg tac gct gtg aca  aca gcg gtc ctc act  cca ctg cta        7050
Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val Leu Thr  Pro Leu Leu            
    2305                 2310                 2315                        

aag cat  ttg atc acg tca gat  tac atc aac acc tca  ttg acc tca        7095
Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn Thr Ser  Leu Thr Ser            
    2320                 2325                 2330                        

ata aac  gtt cag gca agt gca  cta ttc aca ctc gcg  cga ggc ttc        7140
Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr Leu Ala  Arg Gly Phe            
    2335                 2340                 2345                        

ccc ttc  gtc gat gtt gga gtg  tcg gct ctc ctg cta  gca gcc gga        7185
Pro Phe  Val Asp Val Gly Val  Ser Ala Leu Leu Leu  Ala Ala Gly            
    2350                 2355                 2360                        

tgc tgg  gga caa gtc acc ctc  acc gtt acg gta aca  gcg gca aca        7230
Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr Val Thr  Ala Ala Thr            
    2365                 2370                 2375                        

ctc ctt  ttt tgc cac tat gcc  tac atg gtt ccc ggt  tgg caa gct        7275
Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val Pro Gly  Trp Gln Ala            
    2380                 2385                 2390                        

gag gca  atg cgc tca gcc cag  cgg cgg aca gcg gcc  gga atc atg        7320
Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr Ala Ala  Gly Ile Met            
    2395                 2400                 2405                        

aag aac  gct gta gtg gat ggc  atc gtg gcc acg gac  gtc cca gaa        7365
Lys Asn  Ala Val Val Asp Gly  Ile Val Ala Thr Asp  Val Pro Glu            
    2410                 2415                 2420                        

tta gag  cgc acc aca ccc atc  atg cag aag aaa gtt  gga cag atc        7410
Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys Lys Val  Gly Gln Ile            
    2425                 2430                 2435                        

atg ctg  atc ttg gtg tct cta  gct gca gta gta gtg  aac ccg tct        7455
Met Leu  Ile Leu Val Ser Leu  Ala Ala Val Val Val  Asn Pro Ser            
    2440                 2445                 2450                        

gtg aag  aca gta cga gaa gcc  gga att ttg atc acg  gcc gca gcg        7500
Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu Ile Thr  Ala Ala Ala            
    2455                 2460                 2465                        

gtg acg  ctt tgg gag aat gga  gca agc tct gtt tgg  aac gca aca        7545
Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser Val Trp  Asn Ala Thr            
    2470                 2475                 2480                        

act gcc  atc gga ctc tgc cac  atc atg cgt ggg ggt  tgg ttg tca        7590
Thr Ala  Ile Gly Leu Cys His  Ile Met Arg Gly Gly  Trp Leu Ser            
    2485                 2490                 2495                        

tgt cta  tcc ata aca tgg aca  ctc ata aag aac atg  gaa aaa cca        7635
Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys Asn Met  Glu Lys Pro            
    2500                 2505                 2510                        

gga cta  aaa aga ggt ggg gca  aaa gga cgc acc ttg  gga gag gtt        7680
Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg Thr Leu  Gly Glu Val            
    2515                 2520                 2525                        

tgg aaa  gaa aga ctc aac cag  atg aca aaa gaa gag  ttc act agg        7725
Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys Glu Glu  Phe Thr Arg            
    2530                 2535                 2540                        

tac cgc  aaa gag gcc atc atc  gaa gtc gat cgc tca  gcg gca aaa        7770
Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp Arg Ser  Ala Ala Lys            
    2545                 2550                 2555                        

cac gcc  agg aaa gaa ggc aat  gtc act gga ggg cat  cca gtc tct        7815
His Ala  Arg Lys Glu Gly Asn  Val Thr Gly Gly His  Pro Val Ser            
    2560                 2565                 2570                        

agg ggc  aca gca aaa ctg aga  tgg ctg gtc gaa cgg  agg ttt ctc        7860
Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val Glu Arg  Arg Phe Leu            
    2575                 2580                 2585                        

gaa ccg  gtc gga aaa gtg att  gac ctt gga tgt gga  aga ggc ggt        7905
Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly Cys Gly  Arg Gly Gly            
    2590                 2595                 2600                        

tgg tgt  tac tat atg gca acc  caa aaa aga gtc caa  gaa gtc aga        7950
Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg Val Gln  Glu Val Arg            
    2605                 2610                 2615                        

ggg tac  aca aag ggc ggt ccc  gga cat gaa gag ccc  caa cta gtg        7995
Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu Glu Pro  Gln Leu Val            
    2620                 2625                 2630                        

caa agt  tat gga tgg aac att  gtc acc atg aag agt  gga gtg gat        8040
Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met Lys Ser  Gly Val Asp            
    2635                 2640                 2645                        

gtg ttc  tac aga cct tct gag  tgt tgt gac acc ctc  ctt tgt gac        8085
Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp Thr Leu  Leu Cys Asp            
    2650                 2655                 2660                        

atc gga  gag tcc tcg tca agt  gct gag gtt gaa gag  cat agg acg        8130
Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val Glu Glu  His Arg Thr            
    2665                 2670                 2675                        

att cgg  gtc ctt gaa atg gtt  gag gac tgg ctg cac  cga ggg cca        8175
Ile Arg  Val Leu Glu Met Val  Glu Asp Trp Leu His  Arg Gly Pro            
    2680                 2685                 2690                        

agg gaa  ttt tgc gtg aag gtg  ctc tgc ccc tac atg  ccg aaa gtc        8220
Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro Tyr Met  Pro Lys Val            
    2695                 2700                 2705                        

ata gag  aag atg gag ctg ctc  caa cgc cgg tat ggg  ggg gga ctg        8265
Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg Tyr Gly  Gly Gly Leu            
    2710                 2715                 2720                        

gtc aga  aac cca ctc tca cgg  aat tcc acg cac gag  atg tat tgg        8310
Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr His Glu  Met Tyr Trp            
    2725                 2730                 2735                        

gtg agt  cga gct tca ggc aat  gtg gta cat tca gtg  aat atg acc        8355
Val Ser  Arg Ala Ser Gly Asn  Val Val His Ser Val  Asn Met Thr            
    2740                 2745                 2750                        

agc cag  gtg ctc cta gga aga  atg gaa aaa agg acc  tgg aag gga        8400
Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys Arg Thr  Trp Lys Gly            
    2755                 2760                 2765                        

ccc caa  tac gag gaa gat gta  aac ttg gga agt gga  acc agg gcg        8445
Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly Ser Gly  Thr Arg Ala            
    2770                 2775                 2780                        

gtg gga  aaa ccc ctg ctc aac  tca gac acc agt aaa  atc aag aac        8490
Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr Ser Lys  Ile Lys Asn            
    2785                 2790                 2795                        

agg att  gaa cga ctc agg cgt  gag tac agt tcg acg  tgg cac cac        8535
Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser Ser Thr  Trp His His            
    2800                 2805                 2810                        

gat gag  aac cac cca tat aga  acc tgg aac tat cac  ggc agt tat        8580
Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn Tyr His  Gly Ser Tyr            
    2815                 2820                 2825                        

gat gtg  aag ccc aca ggc tcc  gcc agt tcg ctg gtc  aat gga gtg        8625
Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser Leu Val  Asn Gly Val            
    2830                 2835                 2840                        

gtc agg  ctc ctc tca aaa cca  tgg gac acc atc acg  aat gtt acc        8670
Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr Ile Thr  Asn Val Thr            
    2845                 2850                 2855                        

acc atg  gcc atg act gac act  act ccc ttc ggg cag  cag cga gtg        8715
Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe Gly Gln  Gln Arg Val            
    2860                 2865                 2870                        

ttc aaa  gag aag gtg gac acg  aaa gct cct gaa ccg  cca gaa gga        8760
Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro Glu Pro  Pro Glu Gly            
    2875                 2880                 2885                        

gtg aag  tac gtg ctc aac gag  acc acc aac tgg ttg  tgg gcg ttt        8805
Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn Trp Leu  Trp Ala Phe            
    2890                 2895                 2900                        

ttg gcc  aga gaa aaa cgt ccc  aga atg tgc tct cga  gag gaa ttc        8850
Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys Ser Arg  Glu Glu Phe            
    2905                 2910                 2915                        

ata aga  aag gtc aac agc aat  gca gct ttg ggt gcc  atg ttt gaa        8895
Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu Gly Ala  Met Phe Glu            
    2920                 2925                 2930                        

gag cag  aat caa tgg agg agc  gcc aga gaa gca gtt  gaa gat cca        8940
Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu Ala Val  Glu Asp Pro            
    2935                 2940                 2945                        

aaa ttt  tgg gag atg gtg gat  gag gag cgc gag gca  cat ctg cgg        8985
Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg Glu Ala  His Leu Arg            
    2950                 2955                 2960                        

ggg gaa  tgt cac act tgc att  tac aac atg atg gga  aag aga gag        9030
Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met Met Gly  Lys Arg Glu            
    2965                 2970                 2975                        

aaa aaa  ccc gga gag ttc gga  aag gcc aag gga agc  aga gcc att        9075
Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys Gly Ser  Arg Ala Ile            
    2980                 2985                 2990                        

tgg ttc  atg tgg ctc gga gct  cgc ttt ctg gag ttc  gag gct ctg        9120
Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu Glu Phe  Glu Ala Leu            
    2995                 3000                 3005                        

ggt ttt  ctc aat gaa gac cac  tgg ctt gga aga aag  aac tca gga        9165
Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly Arg Lys  Asn Ser Gly            
    3010                 3015                 3020                        

gga ggt  gtc gag ggc ttg ggc  ctc caa aaa ctg ggt  tac atc ctg        9210
Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys Leu Gly  Tyr Ile Leu            
    3025                 3030                 3035                        

cgt gaa  gtt ggc acc cgg cct  ggg ggc aag atc tat  gct gat gac        9255
Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys Ile Tyr  Ala Asp Asp            
    3040                 3045                 3050                        

aca gct  ggc tgg gac acc cgc  atc acg aga gct gac  ttg gaa aat        9300
Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg Ala Asp  Leu Glu Asn            
    3055                 3060                 3065                        

gaa gct  aag gtg ctt gag ctg  ctt gat ggg gaa cat  cgg cgt ctt        9345
Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly Glu His  Arg Arg Leu            
    3070                 3075                 3080                        

gcc agg  gcc atc att gag ctc  acc tat cgt cac aaa  gtt gtg aaa        9390
Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg His Lys  Val Val Lys            
    3085                 3090                 3095                        

gtg atg  cgc ccg gct gct gat  gga aga acc gtc atg  gat gtt atc        9435
Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr Val Met  Asp Val Ile            
    3100                 3105                 3110                        

tcc aga  gaa gat cag agg ggg  agt gga caa gtt gtc  acc tac gcc        9480
Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln Val Val  Thr Tyr Ala            
    3115                 3120                 3125                        

cta aac  act ttc acc aac ctg  gcc gtc cag ctg gtg  agg atg atg        9525
Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln Leu Val  Arg Met Met            
    3130                 3135                 3140                        

gaa ggg  gaa gga gtg att ggc  cca gat gat gtg gag  aaa ctc aca        9570
Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp Val Glu  Lys Leu Thr            
    3145                 3150                 3155                        

aaa ggg  aaa gga ccc aaa gtc  agg acc tgg ctg ttt  gag aat ggg        9615
Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp Leu Phe  Glu Asn Gly            
    3160                 3165                 3170                        

gaa gaa  aga ctc agc cgc atg  gct gtc agt gga gat  gac tgt gtg        9660
Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser Gly Asp  Asp Cys Val            
    3175                 3180                 3185                        

gta aag  ccc ctg gac gat cgc  ttt gcc acc tcg ctc  cac ttc ctc        9705
Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr Ser Leu  His Phe Leu            
    3190                 3195                 3200                        

aat gct  atg tca aag gtt cgc  aaa gac atc caa gag  tgg aaa ccg        9750
Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile Gln Glu  Trp Lys Pro            
    3205                 3210                 3215                        

tca act  gga tgg tat gat tgg  cag cag gtt cca ttt  tgc tca aac        9795
Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val Pro Phe  Cys Ser Asn            
    3220                 3225                 3230                        

cat ttc  act gaa ttg atc atg  aaa gat gga aga aca  ctg gtg gtt        9840
His Phe  Thr Glu Leu Ile Met  Lys Asp Gly Arg Thr  Leu Val Val            
    3235                 3240                 3245                        

cca tgc  cga gga cag gat gaa  ttg gta ggc aga gct  cgc ata tct        9885
Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly Arg Ala  Arg Ile Ser            
    3250                 3255                 3260                        

cca ggg  gcc gga tgg aac gtc  cgc gac act gct tgt  ctg gct aag        9930
Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr Ala Cys  Leu Ala Lys            
    3265                 3270                 3275                        

tct tat  gcc cag atg tgg ctg  ctt ctg tac ttc cac  aga aga gac        9975
Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr Phe His  Arg Arg Asp            
    3280                 3285                 3290                        

ctg cgg  ctc atg gcc aac gcc  att tgc tcc gct gtc  cct gtg aat       10020
Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser Ala Val  Pro Val Asn            
    3295                 3300                 3305                        

tgg gtc  cct acc gga aga acc  acg tgg tcc atc cat  gca gga gga       10065
Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser Ile His  Ala Gly Gly            
    3310                 3315                 3320                        

gag tgg  atg aca aca gag gac  atg ttg gag gtc tgg  aac cgt gtt       10110
Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu Val Trp  Asn Arg Val            
    3325                 3330                 3335                        

tgg ata  gag gag aat gaa tgg  atg gaa gac aaa acc  cca gtg gag       10155
Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp Lys Thr  Pro Val Glu            
    3340                 3345                 3350                        

aaa tgg  agt gac gtc cca tat  tca gga aaa cga gag  gac atc tgg       10200
Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys Arg Glu  Asp Ile Trp            
    3355                 3360                 3365                        

tgt ggc  agc ctg att ggc aca  aga gcc cga gcc acg  tgg gca gaa       10245
Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg Ala Thr  Trp Ala Glu            
    3370                 3375                 3380                        

aac atc  cag gtg gct atc aac  caa gtc aga gca atc  atc gga gat       10290
Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg Ala Ile  Ile Gly Asp            
    3385                 3390                 3395                        

gag aag  tat gtg gat tac atg  agt tca cta aag aga  tat gaa gac       10335
Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu Lys Arg  Tyr Glu Asp            
    3400                 3405                 3410                        

aca act  ttg gtt gag gac aca  gta ctg tagatattta atcaattgta          10382
Thr Thr  Leu Val Glu Asp Thr  Val Leu                                     
    3415                 3420                                             

aatagacaat ataagtatgc ataaaagtgt agttttatag tagtatttag tggtgttagt    10442

gtaaatagtt aagaaaattt tgaggagaaa gtcaggccgg gaagttcccg ccaccggaag    10502

ttgagtagac ggtgctgcct gcgactcaac cccaggagga ctgggtgaac aaagccgcga    10562

agtgatccat gtaagccctc agaaccgtct cggaaggagg accccacatg ttgtaacttc    10622

aaagcccaat gtcagaccac gctacggcgt gctactctgc ggagagtgca gtctgcgata    10682

gtgccccagg aggactgggt taacaaaggc aaaccaacgc cccacgcggc cctagccccg    10742

gtaatggtgt taaccagggc gaaaggacta gaggttagag gagaccccgc ggtttaaagt    10802

gcacggccca gcctggctga agctgtaggt caggggaagg actagaggtt agtggagacc    10862

ccgtgccaca aaacaccaca acaaaacagc atattgacac ctgggataga ctaggagatc    10922

ttctgctctg cacaaccagc cacacggcac agtgcgccga caatggtggc tggtggtgcg    10982

agaacacagg atct                                                      10996


<210>  8
<211>  3422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Ser Thr Ile Thr Leu Leu Cys 
            100                 105                 110         


Leu Ile Pro Thr Val Met Ala Phe His Leu Ser Thr Arg Asp Gly Glu 
        115                 120                 125             


Pro Leu Met Ile Val Ala Lys His Glu Arg Gly Arg Pro Leu Leu Phe 
    130                 135                 140                 


Lys Thr Thr Glu Gly Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu 
145                 150                 155                 160 


Gly Glu Met Cys Glu Asp Thr Val Thr Tyr Lys Cys Pro Leu Leu Val 
                165                 170                 175     


Asn Thr Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr 
            180                 185                 190         


Trp Val Met Tyr Gly Thr Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu 
        195                 200                 205             


Lys Arg Ser Val Ala Leu Thr Pro His Ser Gly Met Gly Leu Glu Thr 
    210                 215                 220                 


Arg Ala Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln 
225                 230                 235                 240 


Arg Val Glu Ser Trp Ile Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala 
                245                 250                 255     


Gly Phe Met Ala Tyr Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val 
            260                 265                 270         


Phe Phe Val Leu Met Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys 
        275                 280                 285             


Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ala 
    290                 295                 300                 


Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr Thr Met Ala 
305                 310                 315                 320 


Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys 
                325                 330                 335     


Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn 
            340                 345                 350         


Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys 
        355                 360                 365             


Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Val Val Asp Arg 
    370                 375                 380                 


Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr 
385                 390                 395                 400 


Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn Leu Val Gln 
                405                 410                 415     


Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His Asn Gly Asp 
            420                 425                 430         


Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val Thr Ala Thr 
        435                 440                 445             


Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro Asp Tyr Gly 
    450                 455                 460                 


Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu 
465                 470                 475                 480 


Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp Leu Val His Lys Gln 
                485                 490                 495     


Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser 
            500                 505                 510         


Glu Val His Trp Asn Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro 
        515                 520                 525             


His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln Glu Gly Ala 
    530                 535                 540                 


Met His Ser Ala Leu Ala Gly Ala Thr Glu Val Asp Ser Gly Asp Gly 
545                 550                 555                 560 


Asn His Met Phe Ala Gly His Leu Lys Cys Lys Val Arg Met Glu Lys 
                565                 570                 575     


Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser 
            580                 585                 590         


Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr Val Val Lys 
        595                 600                 605             


Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro Ile Glu Ile 
    610                 615                 620                 


Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr 
625                 630                 635                 640 


Pro Leu Ala Glu Asn Thr Asn Ser Ala Thr Asn Ile Glu Leu Glu Pro 
                645                 650                 655     


Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asn Ser Ala Leu 
            660                 665                 670         


Thr Leu His Trp Phe Arg Lys Gly Ser Ser Ile Gly Lys Met Phe Glu 
        675                 680                 685             


Ser Thr Tyr Arg Gly Ala Lys Arg Met Ala Ile Leu Gly Glu Thr Ala 
    690                 695                 700                 


Trp Asp Phe Gly Ser Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala 
705                 710                 715                 720 


Val His Gln Val Phe Gly Ser Val Tyr Thr Thr Met Phe Gly Gly Val 
                725                 730                 735     


Ser Trp Met Ile Arg Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly 
            740                 745                 750         


Thr Asn Ser Arg Asn Thr Ser Met Ala Met Thr Cys Ile Ala Val Gly 
        755                 760                 765             


Gly Ile Thr Leu Phe Leu Gly Phe Thr Val Gln Ala Asp Ser Gly Cys 
    770                 775                 780                 


Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe 
785                 790                 795                 800 


Ile His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro 
                805                 810                 815     


Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu 
            820                 825                 830         


Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp 
        835                 840                 845             


Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val 
    850                 855                 860                 


Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala 
865                 870                 875                 880 


Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys 
                885                 890                 895     


Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr 
            900                 905                 910         


Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg 
        915                 920                 925             


Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser 
    930                 935                 940                 


Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp 
945                 950                 955                 960 


Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser 
                965                 970                 975     


Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu 
            980                 985                 990         


Glu Arg Ala Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
        995                 1000                 1005             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1010                 1015                 1020             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1025                 1030                 1035             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1040                 1045                 1050             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1070                 1075                 1080             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1085                 1090                 1095             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1100                 1105                 1110             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1115                 1120                 1125             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1130                 1135                 1140             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1145                 1150                 1155             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1160                 1165                 1170             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1175                 1180                 1185             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1190                 1195                 1200             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1205                 1210                 1215             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1220                 1225                 1230             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1235                 1240                 1245             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1250                 1255                 1260             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1265                 1270                 1275             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1280                 1285                 1290             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1295                 1300                 1305             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1310                 1315                 1320             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1325                 1330                 1335             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1340                 1345                 1350             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1355                 1360                 1365             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1370                 1375                 1380             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1385                 1390                 1395             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1400                 1405                 1410             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1415                 1420                 1425             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1430                 1435                 1440             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1445                 1450                 1455             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1460                 1465                 1470             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1475                 1480                 1485             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1490                 1495                 1500             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1505                 1510                 1515             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1520                 1525                 1530             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1535                 1540                 1545             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1550                 1555                 1560             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1565                 1570                 1575             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1580                 1585                 1590             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1595                 1600                 1605             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1610                 1615                 1620             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1625                 1630                 1635             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1640                 1645                 1650             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1655                 1660                 1665             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1670                 1675                 1680             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1685                 1690                 1695             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1700                 1705                 1710             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1715                 1720                 1725             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1730                 1735                 1740             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1745                 1750                 1755             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1760                 1765                 1770             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1775                 1780                 1785             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1790                 1795                 1800             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1805                 1810                 1815             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1820                 1825                 1830             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1835                 1840                 1845             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1850                 1855                 1860             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1865                 1870                 1875             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1880                 1885                 1890             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1895                 1900                 1905             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1910                 1915                 1920             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1925                 1930                 1935             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1940                 1945                 1950             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1955                 1960                 1965             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1970                 1975                 1980             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    1985                 1990                 1995             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2000                 2005                 2010             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2015                 2020                 2025             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2030                 2035                 2040             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2045                 2050                 2055             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2060                 2065                 2070             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2075                 2080                 2085             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2090                 2095                 2100             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2105                 2110                 2115             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2120                 2125                 2130             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2135                 2140                 2145             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2150                 2155                 2160             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2165                 2170                 2175             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2180                 2185                 2190             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2195                 2200                 2205             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2210                 2215                 2220             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2225                 2230                 2235             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2240                 2245                 2250             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2255                 2260                 2265             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2270                 2275                 2280             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2285                 2290                 2295             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2300                 2305                 2310             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2315                 2320                 2325             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2330                 2335                 2340             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2345                 2350                 2355             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2360                 2365                 2370             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2375                 2380                 2385             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2390                 2395                 2400             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2405                 2410                 2415             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2420                 2425                 2430             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2435                 2440                 2445             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2465                 2470                 2475             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2480                 2485                 2490             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2495                 2500                 2505             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2510                 2515                 2520             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2525                 2530                 2535             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2540                 2545                 2550             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2555                 2560                 2565             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2570                 2575                 2580             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2585                 2590                 2595             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2600                 2605                 2610             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2615                 2620                 2625             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2630                 2635                 2640             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2645                 2650                 2655             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2660                 2665                 2670             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2675                 2680                 2685             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2690                 2695                 2700             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2705                 2710                 2715             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2720                 2725                 2730             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2735                 2740                 2745             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2750                 2755                 2760             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2765                 2770                 2775             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2780                 2785                 2790             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2795                 2800                 2805             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2810                 2815                 2820             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2825                 2830                 2835             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2840                 2845                 2850             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2855                 2860                 2865             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2870                 2875                 2880             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2885                 2890                 2895             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2900                 2905                 2910             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2915                 2920                 2925             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2930                 2935                 2940             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2945                 2950                 2955             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2960                 2965                 2970             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2975                 2980                 2985             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    2990                 2995                 3000             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3005                 3010                 3015             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3020                 3025                 3030             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3035                 3040                 3045             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3050                 3055                 3060             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3065                 3070                 3075             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3080                 3085                 3090             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3095                 3100                 3105             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3110                 3115                 3120             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3125                 3130                 3135             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3140                 3145                 3150             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3155                 3160                 3165             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3185                 3190                 3195             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3230                 3235                 3240             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3245                 3250                 3255             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3365                 3370                 3375             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3380                 3385                 3390             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3395                 3400                 3405             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3410                 3415                 3420         


<210>  9
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dengue 2 virus C protien/prM protein junction


<220>
<221>  CDS
<222>  (1)..(75)

<400>  9
aga cgc aga tct gca ggc atg atc att atg ctg att cca aca gtg atg         48
Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val Met           
1               5                   10                  15                

gcg ttc cat tta acc aca cgt aac gga                                     75
Ala Phe His Leu Thr Thr Arg Asn Gly                                       
            20                  25                                        


<210>  10
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val Met 
1               5                   10                  15      


Ala Phe His Leu Thr Thr Arg Asn Gly 
            20                  25  


<210>  11
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  West Nile virus/Dengue 2 virus chimera C protein/prM protein 
       junction


<220>
<221>  CDS
<222>  (1)..(75)

<400>  11
aag aaa aga tcc gcg ggc atg atc att atg ctg att cca aca gtg atg         48
Lys Lys Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val Met           
1               5                   10                  15                

gcg ttc cat tta acc aca cgt aac gga                                     75
Ala Phe His Leu Thr Thr Arg Asn Gly                                       
            20                  25                                        


<210>  12
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Lys Lys Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val Met 
1               5                   10                  15      


Ala Phe His Leu Thr Thr Arg Asn Gly 
            20                  25  


<210>  13
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  West Nile virus C protein/prM protein junction


<220>
<221>  CDS
<222>  (1)..(87)

<400>  13
aag aaa aga gga gga aag acc gga att gca gtc atg att ggc ctg atc         48
Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala Val Met Ile Gly Leu Ile           
1               5                   10                  15                

gcc agc gta gga gca gtt acc ctc tct aac ttc caa ggg                     87
Ala Ser Val Gly Ala Val Thr Leu Ser Asn Phe Gln Gly                       
            20                  25                                        


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala Val Met Ile Gly Leu Ile 
1               5                   10                  15      


Ala Ser Val Gly Ala Val Thr Leu Ser Asn Phe Gln Gly 
            20                  25                  


<210>  15
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  West Nile virus/Dengue 1 virus chimera C protein/prM protein 
       junction


<220>
<221>  CDS
<222>  (1)..(75)

<400>  15
aag aaa aga tcc gtg acc atg ctc ctt atg ctg ctg ccc aca gcc ctg         48
Lys Lys Arg Ser Val Thr Met Leu Leu Met Leu Leu Pro Thr Ala Leu           
1               5                   10                  15                

gcg ttc cat ctg acg aca cga ggg gga                                     75
Ala Phe His Leu Thr Thr Arg Gly Gly                                       
            20                  25                                        


<210>  16
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Lys Lys Arg Ser Val Thr Met Leu Leu Met Leu Leu Pro Thr Ala Leu 
1               5                   10                  15      


Ala Phe His Leu Thr Thr Arg Gly Gly 
            20                  25  


<210>  17
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  West Nile virus/Dengue 3 virus chimera C protein/prM protein 
       chimera


<220>
<221>  CDS
<222>  (1)..(75)

<400>  17
aag aaa aga aca tcg ctc tgt ctc atg atg atg tta cca gca aca ctt         48
Lys Lys Arg Thr Ser Leu Cys Leu Met Met Met Leu Pro Ala Thr Leu           
1               5                   10                  15                

gct ttc cac tta act tca cga gat gga                                     75
Ala Phe His Leu Thr Ser Arg Asp Gly                                       
            20                  25                                        


<210>  18
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Lys Lys Arg Thr Ser Leu Cys Leu Met Met Met Leu Pro Ala Thr Leu 
1               5                   10                  15      


Ala Phe His Leu Thr Ser Arg Asp Gly 
            20                  25  


<210>  19
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  West Nile virus/Dengue 4 virus C protein/prM protein junction


<220>
<221>  CDS
<222>  (1)..(75)

<400>  19
aag aaa aga tca acg ata aca ttg ctg tgc ttg att ccc acc gta atg         48
Lys Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu Ile Pro Thr Val Met           
1               5                   10                  15                

gcg ttt cac ttg tca aca aga gat ggc                                     75
Ala Phe His Leu Ser Thr Arg Asp Gly                                       
            20                  25                                        


<210>  20
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Lys Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu Ile Pro Thr Val Met 
1               5                   10                  15      


Ala Phe His Leu Ser Thr Arg Asp Gly 
            20                  25  


